<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ11</accession>
    <name>A0A061CZ11_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0101900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766047.1">
        <property type="nucleotide sequence ID" value="XM_012910593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ11"/>
    <dbReference type="STRING" id="5866.A0A061CZ11"/>
    <dbReference type="GeneID" id="24562402"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101900"/>
    <dbReference type="OMA" id="QIECLNC"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="27"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="381" mass="42661" checksum="8763B549D24ED225" modified="2014-09-03" version="1">MHVIKQYLGFGEAMPGRDSTAGGIGPSGLENTYNNCYCNAVLQALYPIHAFRDRAVRLSQSEAEISSALGQLYERCTGLNGVQSPKKLLQKICKKNEYFVLGDQQDAHEFLTYLINTMMDEIKALNNGDQPSGGAGNDYSRHRGGDGGSGRDLAGKCRAPEITSQKEQKSERTWLSRLVEGSLKSETTCDGCLTVTGTLEPFITLSVDIFENCDIASCIQQYCAPERLTGKNQFYCDRCREYTDASKRVVFEKLPPIFIVHLKRFRYTAVSPNESYSAMYDSFERLPYPVISNRRVTLQSRKQRSTVVYELFAVVNHVGTSPSYGHYNAITEVDGRWYCCDDSSTVRVSDVSYELGDEQSGGNSNSYILFYRMTALADRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ16</accession>
    <name>A0A061CZ16_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766052.1">
        <property type="nucleotide sequence ID" value="XM_012910598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ16"/>
    <dbReference type="GeneID" id="24562407"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101950"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="9594" checksum="7525F1865A81CE1D" modified="2014-09-03" version="1">MEQVIIDTANYAEDISTCVKHIEKNADRMIHFGPPPQKHHSERDKNDNAREDVEQSSNDTFSAGSEDGTEDLPPEEDHNSESEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ31</accession>
    <name>A0A061CZ31_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0102100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766067.1">
        <property type="nucleotide sequence ID" value="XM_012910613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ31"/>
    <dbReference type="STRING" id="5866.A0A061CZ31"/>
    <dbReference type="GeneID" id="24562422"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102100"/>
    <dbReference type="OMA" id="DIFYFCS"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10289">
        <property type="entry name" value="GST_C_AaRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="63"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="6">
        <location>
            <begin position="238"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="401" mass="44059" checksum="25E4A1425457FA40" modified="2014-09-03" version="1">MLEVVVYKDCVEGRLATLLWGYGKLTSATLSFAPSRTGMVVKEDGKETPMIWPTLLELAVKDAPTESILVPATEAQKVSALRPVFNFACQRTMYSWIDFAYQRDFSIMESASLKILNDYILNHTFLAGPTVTLADLVVYVSTHSWMMKSEPQDRAEYVNVVRWFDHIQHLPGIVNTFKELPLVSVDKDMDVVTAVMEKATVSAAAPAPAGKQAKGQKGAASKKPKDPKPPADDRPIADVSRLNIKVGQIMSVERHPEADKLYCLKVDLGEPELRDICSGLVGYLEPEQIMSQYVCVLSNMKPKSLRGKVSNGMILCVSGPGKTELELLHPAEGAPVGERIIIEDCVGEPDAVLSTKTGKDPFVAVQPEFNCKDTVAYYKDHRFMTSCGPCRCNSLKAGTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZR9</accession>
    <name>A0A061CZR9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">tRNA carboxymethyluridine synthase</fullName>
            <ecNumber evidence="14">2.3.1.311</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0102370</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="14"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766094.1">
        <property type="nucleotide sequence ID" value="XM_012910640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZR9"/>
    <dbReference type="STRING" id="5866.A0A061CZR9"/>
    <dbReference type="GeneID" id="24562449"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102370"/>
    <dbReference type="OMA" id="NLGCTRV"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF2">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Elp3/MiaA/NifB-like radical SAM core" evidence="17">
        <location>
            <begin position="472"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="242"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR93908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1077" mass="120157" checksum="5CBA6D0B93BDDA2D" modified="2014-09-03" version="1">MEPSKLVAAPADSDGGQPGARNFADQSLSEDEVSTVFEAAVVPDELDSAVVVEHHSPVVAETVLPEDVAKPHIEPPLDDDVDVDSDAVVDQSPKAYAEISNDVADDSVEAPENLTVEQSLDANGDVEPPTGVAAVDFEAVVSDALETNRASPSRPRSHPITNGRGGIDSEVVGQEPYDALVEPYVVDGEMSPTSDSPVVGIVPPSNTPIQSMRVSSSTEGNLSFGSSTVSGGACDIVDREVEGGTPARDDFNDYIPSPSRQPAVEGSGKHDAEGENDSDSDSEEEMRNFFPATRESFKEVAGKVTRVTRADFGDSNRRRHLECFARSMDSWRNFESKANQDPNASLYTELQFDRYDDIFVDIDVSTLSTLDQFIYELLSSSENVKDQDELNLLMSKLRRQYHIGPSKRDIFERLLQLQMEREAKKQSSVSSTGSNGSGDFVAGRSTPTSVKYDPKMQHLLRNKGVRSNSGVVVITVLTAPGNFSCSSDCYYCPNEPGQPRSYLSTEPAVLRANQNDFDAARQFYDRAMTLYRNGHVIDKIEVLVLGGTWSGYPRQYQEEFCRDLYYAANVFPTPLEVARPRESLESEQEMNVGGLCRIIGLTLETRPDRITPTEIRILRNLGCTRVQLGIQHTNDDVLNHVNRGHGLDESKRALYLLKENCYKVDVHLMPDLPSSNPDMDREMFALMLGDEGLQADQWKIYPCEVTPFSQIEQWHKQGLFVPYFDTDPNLLMDLLMSVKRAVHPWIRLNRVIRDIPNPSIIAGTNVTNLRQLLLNRMQKCGLMCRCIRCREMKKGSTSLGAKLMVREYRATGGTEYFLSYESQDESKIFGFLRLRLRDNSDFDPKVSTFRCLEGCAFIRELHVYGVVVAHGKAVKEATPYQHRGIGASLLLVAEILAGAKGFRKMAVIAGIGTREYYAKHGYEVEDTFMTKMLDHESIRTRFLKQMERDPSSSIQIPYSIKVNVIDLQDAVRTLHLPLPPAFQGKNPPPVVSVPTSGPYFHINVLRFLRYASHNFDAGVDYTKATTVMFDEYFAYVDRAAASMYKSLQAIQERRVVAASVAFLAVMCYTRFRQRSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D005</accession>
    <name>A0A061D005_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766362.1">
        <property type="nucleotide sequence ID" value="XM_012910908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D005"/>
    <dbReference type="GeneID" id="24562717"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104850"/>
    <dbReference type="OMA" id="CANEVEM"/>
    <dbReference type="OrthoDB" id="365788at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="18947" checksum="BD01C8BDC4FC7ECB" modified="2014-09-03" version="1">MANSAVESPCFPRNILRKTCAYSVGNCPNGPIAQLYYLSAKIYRCVNYAFNTLQPSDKFIEGEYAAGVHQRVSVSLVKSEVEEMIRLNSVAAQGCHYDVSSTACDDSTDDHESDSGIPTPSCGISFDFADVGAEDRGDDSAFVTRLDAGEAKLPPDMDEFLELLMVCAKEVGQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0E0</accession>
    <name>A0A061D0E0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766329.1">
        <property type="nucleotide sequence ID" value="XM_012910875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0E0"/>
    <dbReference type="GeneID" id="24562684"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104520"/>
    <dbReference type="OMA" id="GKNYNMG"/>
    <dbReference type="OrthoDB" id="407066at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="228" mass="26031" checksum="1935B8EEF2626F72" modified="2014-09-03" version="1">MYINEYFGAHYLRRCVRHFGVSGSYGPSIYGIQTTETNTRLIRLPQEAPPPQIDINARLHVAQWPGKIRALRSGYFFRPEQRTNTGYYHMLIKGKKDVCLVSNAVKSQTATKTIENCLHERTRGFSGQVLLHGRGVKAFFEPQFPHLMFRLGVGSNCLDATRICTMYAKHVKVEVDRTGLIVSVHGYNKMMVGNVVYRLFRLVEANPYTLKGGHIANYPIKKKTPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0M3</accession>
    <name>A0A061D0M3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766532.1">
        <property type="nucleotide sequence ID" value="XM_012911078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0M3"/>
    <dbReference type="GeneID" id="24562887"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106550"/>
    <dbReference type="OMA" id="SLTHMIR"/>
    <dbReference type="OrthoDB" id="365864at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599903" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="19374" checksum="A125E3D9D14005D2" modified="2014-09-03" version="1">MRSRCLFVINLVFLLPVAIASKINTTFRPISRHASLNEISLLEEDIKQGNNVEDQKKKTDSEVKPAEPLNLIFSPTAQQVSDENNQLLESMESGLHSLRTVVNKLTRLVHLLPENEKQSTFTVGNQNYTVAEMLDGINSLIVDGEKQQRVLVEGTAEILHKLAAPIAASQTTQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D163</accession>
    <name>A0A061D163_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766742.1">
        <property type="nucleotide sequence ID" value="XM_012911288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D163"/>
    <dbReference type="GeneID" id="24563097"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108540"/>
    <dbReference type="OMA" id="EAEMLIC"/>
    <dbReference type="OrthoDB" id="449128at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="306" mass="33596" checksum="67AACB975461821E" modified="2014-09-03" version="1">MYSRRLLKYLAAAALWRWLPRAMSLSHIPDGPIGLPSNVRIRAEHRHRKQRKTAEIHSDVPPAQLSTEAVSEIATASHSFEAMRDQLKEEEIQGIHLDLPQIPMKSVLQLIPAFIYSLPSSMMGVKRFVEDSTYALVNMGLQSVLGSQVFQNVLCTPQSNEAEMLICVSDMVANISRVIHTGITVLTLNFRSLVGGRTASDALVRLNTIAANPLNRTLMKVLGTTAVLYITMMRESVPDETKVLAGSIMTELTSLPIVSNIPDTSSGGFGRVNVVLPRPSRMHRADYDIAKLQAGAGERDLLSSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1G7</accession>
    <name>A0A061D1G7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acylphosphatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766148.1">
        <property type="nucleotide sequence ID" value="XM_012910694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1G7"/>
    <dbReference type="GeneID" id="24562503"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102855"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102855"/>
    <dbReference type="OMA" id="VIATSYM"/>
    <dbReference type="OrthoDB" id="406969at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="2">
        <location>
            <begin position="93"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="28201" checksum="046A771F415F1DF5" modified="2014-09-03" version="1">MSTYFPKSLKNKAKSTLPVVRQSLLLPRLRPAKSLYDTANVHPVLSRGYPVFDTIFDTLNDKASGLRKYKPKEERPVVRTDYNAENMHEMNHRFRFKLAGTFNGEVPSPPPPPHVSAAKSFESELESYCNQLFLVGWIKCRRYFAIGHVGAAPVLRPIPQLQGNVIATSYMKRWMQISGAKSAHFNSAVFFDENYAIPKLDYQELTVVRDYRKPQKKAQHQRAVSAPTSVVKMTPQVEERRGVHGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1R2</accession>
    <name>A0A061D1R2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766258.1">
        <property type="nucleotide sequence ID" value="XM_012910804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1R2"/>
    <dbReference type="GeneID" id="24562613"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103850"/>
    <dbReference type="OMA" id="EIYFCNF"/>
    <dbReference type="OrthoDB" id="363744at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1025" mass="114928" checksum="41B00CBA86BD3669" modified="2014-09-03" version="1">MTVKAAAVAVSGAIQAVRAVVQRSRAETKDLCAVLNRCCANKAHRYVLSSVDSVFHGLTIPSNADAEWSGDRKSAVLTLCKLPRAVYLPRSSDVTRPGPDLGAVLDGELQSWDSVERTLQDYSAFASELAETAEFVSAHSLDGAFGPLRPSAVEVLNKYKQLLLQDTRLGDLRKLTYAAQLLHVLKMHSIDSDNLTELISAIVAKTPQILRQCSLPTLDSIAKIKLPSKEKEYLDYFLRMVTTKPMKLKQWSELFWLVARNSDNRNTIDSFLHCYKIVARHMNRVESAEGAKEKAKSVLCSSLMNVVYGVTTLQKRLRPSDPVYKNALGVLEAVWPLIEARLQRFEHAELIDIAHCYLEHHKAINPQMRHGSRNCVDLLVREFVKRSGDFMLRDWVALFEVLDTSRDAMVVNVLMQKPANYYVRVAAVQQAWVEDLARALEQLPLEELADNVYSLSLPQCSNLCKHLVAAGCYNAPVSAVLERRCLALITDLKYQTTRHVMDFYFVQLQMVLPQHNALRSALESNKPLRTSLEQMSCNTMLRLLGIARHCGPAERRVLLQKLAERIESNVLKLAHHQCLTVLRYAARFKDGNLTNAVLAAAIPPLLETPERHKGFYKMLEISKFALSLPRDECSETSPAVILSELVVQHAPAHVRHLTIPHLDLLLQNVNRSGMLPKPLFEVVLSHAMEVEIMGAPAAQLSSMMRTLSELGVRHENLLERLEEAVIMSVADDEPAVVSEVLVSAATSLAHLGMRTAKLNELFEHVLARKPVTLSRWDYDALSRPAQVNLLHAMALFGTVNEDLERVFTQLVRDCEREVKDGGDAVSFAALDAEAHRKLYDTYISLLVGGFATGTEEGALAKSEFLLEHLPCYHWFSHREQLCTDFKASPHYLQFKGTLEQLGLEGAEPRVTEAYFAHAVLDSPECKRRLPQGGHILYCVPPSHELRWWTPKGDTAADATVNRIESYQRAIGQSARVIDHLQRSGWNVATVFLREWDALEPEQRGRHLLKALKLKDITEADTSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Z3</accession>
    <name>A0A061D1Z3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766328.1">
        <property type="nucleotide sequence ID" value="XM_012910874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Z3"/>
    <dbReference type="GeneID" id="24562683"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104510"/>
    <dbReference type="OMA" id="NCEPTSS"/>
    <dbReference type="OrthoDB" id="366111at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="591" mass="63639" checksum="A5FF191EF14CC5E8" modified="2014-09-03" version="1">MLSGATLPDAAVGRNAISPTNAASTPRSRRPRRAANPQDRTHSSIDSIESLRFMSDSTSVYSPSSSARTTPVRVDGAGLPSAAMLSRTRSAGGPDIDTGNGGGSQSPPSLERSAVPTIQSIKVGDDKGPCLSPGLGERAAALTSKSGLRERPGRSTGSKQLLLNCSDTTVAVEPRKKRAKRKAVVKPEPAEIPVPPIRKPAPVDTSVPFWLTTPKDVKDIASYVKTICSRISNIEKTMKRFESERQGLLNALYQLNVRQLQESFPSRWNAAECDRLNATRPKDVEQTRPDGAELVAAATSLNGDGPGVTRGSSAGARTTVPAKESMSPKENACAAVSVANVLTDYTLPRDAKQEPTVAKAATETTASPQAESGEGVVSQNGAIQCVPDVIEIVDDGDVEEHKSHAEQAGPPEPPCKGQVDDDSESSFTDVSHHAMQRVGSSVHGNDDELEFIGESQLDRNVANYNADDFMESNVLNDFRMWRSCWLKSNDKPEAVSPSRAVMRSAGNYRCNRNEGSLSPGSEGRGVRVENASAEPQGDPLDRFWNLDFRAMSQPNMLRWARFFGIKTSNSTRSMAEELEKIRSYLSSFNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D291</accession>
    <name>A0A061D291_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanine nucleotide-binding protein-like 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766408.1">
        <property type="nucleotide sequence ID" value="XM_012910954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D291"/>
    <dbReference type="STRING" id="5866.A0A061D291"/>
    <dbReference type="GeneID" id="24562763"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105310"/>
    <dbReference type="OMA" id="PNCIFKK"/>
    <dbReference type="OrthoDB" id="360900at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanine nucleotide-binding protein-like 3 N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="83" mass="9831" checksum="78726882D7237089" modified="2014-09-03" version="1">MVKLKKGSKRQELSRKYNIQRMVAAHKKKMRRIAKKGEKTTPRIKPPQIPNCIFKREVLENIKRTKQINDKHAHKSKDKQTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2G5</accession>
    <name>A0A061D2G5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pantothenate kinase domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0201180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767147.1">
        <property type="nucleotide sequence ID" value="XM_012911693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2G5"/>
    <dbReference type="STRING" id="5866.A0A061D2G5"/>
    <dbReference type="GeneID" id="24563502"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201180"/>
    <dbReference type="OMA" id="FAICESM"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595700" evidence="4">
        <location>
            <begin position="28"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="456" mass="49893" checksum="100AEFFDD242C8FB" modified="2014-09-03" version="1">MPDKILSVLKTTLHDLLLLLDIASAEAQNHQLIEESAHKVAHDYYNFANGVISILQHRVNDASDVSHGLHLPDNAAIGVPSLFTGKAAPILRDIYSTSCKIKCAVVKRWTQCEDDSSHHLDGREFSLQGQLPLLPFASGHATSKALKKLSLDIGGTLIKMAYCCQCNDCDAFSLVYCAQHALHDLLHCLERHYNIDRVSHCEVDRNLRRMLPTMIRLDSDSNTQINATGGGAYKYAKLFRERLPQCQFRQIPEMPCVVGGTESMHDVHSCFIRYHLREGYTQLTSAVCYPYLIVNIGSGISILNVTSKGCFERVTGTSIGGATAHGLTNTLLGLETYEDFPILYDKGTNCMDSFSPAPPEATASSDRLKASVEDVARSTSDMVSYNIGQVAFLVARSYGVNRIVFTGSYTTNYRMTIDVAARAVASMAESYEVAPMDVLVSVCGSYAGALGCLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Y5</accession>
    <name>A0A061D2Y5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767164.1">
        <property type="nucleotide sequence ID" value="XM_012911710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Y5"/>
    <dbReference type="GeneID" id="24563519"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201350"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="75" mass="7988" checksum="489AFEAC19B837BF" modified="2014-09-03" version="1">MMHTIYAQTRALIQSLCVVRAYALATSSAAHSGSRGRRALGSVAFSYSNVKNQCNAKKSELSSSKVESHIGVTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Z1</accession>
    <name>A0A061D2Z1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0107600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766648.1">
        <property type="nucleotide sequence ID" value="XM_012911194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Z1"/>
    <dbReference type="STRING" id="5866.A0A061D2Z1"/>
    <dbReference type="GeneID" id="24563003"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107600"/>
    <dbReference type="OMA" id="NIDTESH"/>
    <dbReference type="OrthoDB" id="361400at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="354" mass="39597" checksum="4D7A3135E1C58E80" modified="2014-09-03" version="1">MMDNALFFSGGSVTASGLTAAAVREKGCSEYTLEAGALVLASGGTCCIDELDKTTTAQQNSLLEAMESQSVSLAKGGIVCTLTAQCTVICAANPSGGRFNTSISVTKNIKLLAPLVSRFDLIFFIADKRSEEADDYIASHILKKDLKRQYSTREVRPEPVSLKDHVTYYRANEFLDENLLRSYIEYAKAYVNPVFTRPARKQLRKFYSELRQLSKMHNGLVITTRQLEGIIRLCQARARGDLCDRVTEEHVNDVCELFKQTGYYPGYLDTMSRPSEVVEPVKKARPKTSISIMAAFISRLPANRTVTITHQEMMEYARQTLKVCQSERDPRDLIERANLAGHILKKGNNWTVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Z5</accession>
    <name>A0A061D2Z5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767174.1">
        <property type="nucleotide sequence ID" value="XM_012911720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Z5"/>
    <dbReference type="GeneID" id="24563529"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201450"/>
    <dbReference type="OMA" id="QAQSHWI"/>
    <dbReference type="OrthoDB" id="361427at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="577" mass="62299" checksum="3F726240C5BCB094" modified="2014-09-03" version="1">MPPKKRGSVVKKIRRKALSAQKGRAQGTAARPKTAPSAHTAVTDIKRIDTLDGYKRLVARACTEATGAPENGLQGVKALFDVVAGRGGGTAELREFASALALRSMVAVAVHLIPRISYELLDEEDESADPPGGKSAAGGKGATAPAKHSAGAASKVNKPRPTASSLVETERSISKQVVELRDMLVKHCSNHLKKKPELIVPLVARLAAADTRPNAPLIRLCAECCSIEDEELAQVCLGSITEVLEQSSIRDLEKVIPLLLKSDRPQSALLRAINSIPLARKQHSYKLISEKEQTADKHIEEILTSVIAFYLRILAQCTGEMLEECLKGLSRMGALVNEPLQKEILAKMKSIILSATSLRPATHVRVLQAAASLSRVLQAQSHWILQELARMVQNTAAYLCQGEAMRDGEYVQFSTPCYTWDVIRTVQVVISHSASVAAAAELEDLVKLVQQLLALCLVCDAAVAEALVREVVKVIERVPQIAGVMEPDGMVFSVLAKRATSFWEIELLRKHVAPQIAEQAQELGRQALGGAPTRNKAAASAHRRASARDLAACGSDVYELLLGDEDDIFSQHKPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D305</accession>
    <name>A0A061D305_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD-repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0203080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767337.1">
        <property type="nucleotide sequence ID" value="XM_012911883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D305"/>
    <dbReference type="STRING" id="5866.A0A061D305"/>
    <dbReference type="GeneID" id="24563692"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203080"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="483" mass="53167" checksum="3B32B6D32DCEDE3B" modified="2014-09-03" version="1">MAPTDTEVIVQFRDANEGVLGSTLTVPVHLSRDRLEELLRSLLASEELEGADDDSIRYTFILENSQEIATTLEAALEALGGERSGEGVLNIKYVPLSIYKIRPVTRCSSSLEGHSESVLCMDFSPDGTMLATGSGDSAVRIWDLQTATPIKTLKGHTNWVLGVLWSPDCKRLASAGMDGRVLMWDPSSPQSHHSTLSGHTKAVTTLAWQALHLLDLSVREYPLLASGSMDCSIKIWDVVTGQCMRTLSGHTRGVSQVIWSGEKGNWLFSASRDTLLKVWDTSTGGLVKDLKGHAHWVNTLTSNTHRVIKCGPFSADNFQRGHTQFSGIEEMVQESQRIYKKFIGESGQERLLSGSDDNTMFIWLPHAQSRKPAHRLTGHQQLINHVSFSADGRFFASASFDKTVRIWCGITGKFLRVLRGHIGRVYRVVWSCCGNLLVSCSSDTTLKLWDAATGKLKFDLPGHADEVYTVDWSNCGRTVASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D344</accession>
    <name>A0A061D344_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTPase subfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0108150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766703.1">
        <property type="nucleotide sequence ID" value="XM_012911249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D344"/>
    <dbReference type="STRING" id="5866.A0A061D344"/>
    <dbReference type="GeneID" id="24563058"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108150"/>
    <dbReference type="OMA" id="LICNRIP"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="462"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="830"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="860" mass="97512" checksum="A1898179705FA5A9" modified="2014-09-03" version="1">MGGGKSQKGGKHGFIGRTLAHDILARQAKQDDLMLGDRPYRPVEHSVVERKSLDEFTLAAEHGLETYLSTRGGTREVLASDFNTQLARMVDYSESKDDRVFPAVPIPRRCLFFDDEQRETIAKLIKQREHAQHLKEKRVNKRRNKKLVDMYMHGSGPKPVNGIFDPLKLRTKMKNASHGNVVGSGSDSEDLSDFDLEDDEEGEEEPGYATDEEDEGAEGSEGSSECDSEVSEDSSEDSEDEGANDAARTPMSPARSKRSVRFAEPLRSPAGAPKWRRQPTGIALKSGRMNTFKARANMAKRTSQDDYSSEEDEDDDISDEYYSDDDVEEEEDEDEDEDGIDEGEDEDEDEDDSGFETEEIVETPPPEAALPARAESCGVKVSESQPNENVKVKQVARDLKYVKEYKTAIEHEVSSVDICKMDANELNRIETKCFYTWRKLLAQIEDEEERVVTPYEKNIEFWRQLWRVIERSHILLIIIDARDPLFYRVPDLESYVKEVDSRKEMMLILNKADYLTLELRKAWAEYFKSQGIDFVFFSTIWGKNDKPHAGAEQQQEDPCCKVYNVAMLLEKINGYRQRQSAVFSELNDADNAEIPLYTVGFVGYPNVGKSSLINCLMEATKTNVSCQPGKTKHLQTLPLKKENITLCDCPGLIFPNIVSTKHHLLINGIVATAHFRGSLIFAVQLICNRIPKQLCERYDVDRAECVILGRDSKPILFSQKFLEFICHSRKFYSGGKGGQPDLGRAAKLVVKDYVSGSLLYCAWPPTCRQTMVEFEAEQTRDLAESLSNLNIAGKGTSRLNNDMKVSSEVKREESKLQEWLLATGEDIPEAKEKPMTKRKMRFLIKGKRKSDKKKTVEPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D361</accession>
    <name>A0A061D361_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0108300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766718.1">
        <property type="nucleotide sequence ID" value="XM_012911264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D361"/>
    <dbReference type="STRING" id="5866.A0A061D361"/>
    <dbReference type="GeneID" id="24563073"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108300"/>
    <dbReference type="OMA" id="HEATENA"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053276">
        <property type="entry name" value="MtDNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48448">
        <property type="entry name" value="MUTL PROTEIN ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48448:SF1">
        <property type="entry name" value="MUTL PROTEIN ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="699"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1108" mass="121427" checksum="3DCCEAD4C4B31FA1" modified="2014-09-03" version="1">MRCLLLRALLAARPGFQCGGRHGAFLCAKRGFSAERPVDRGNGTLETHLSGLANAQARQIVAQIAQKNQHLRTSKPAVLTEALELAKAEHPNCVIVTRCGEYYEVHGTDVALCIEYCGLQPTGVTPHLEIPPDRLPHAIEALRRRGIGMAIYDYVTALESEHEDDERLVLRKSLVFSHEAQPTDGHVTHDRQSTDSNFTGSALGVAHNRSGYSVSVIDPVKRTVEVRDRLTFASALSLLQTDDCRVVIFQNGNTHVKKLLSQVSTAIHYEPLQGHNSTKAFHDAACRSIKMRLEMRGSFRVINTATSHMERIPLDLETASVLGLGDGGGTGTGNTNGLHLQMLPGNAPVYMKRYMRFMLAQPPPAEVAEDVRYVIGKLAQMQVPLVDARPVSPFKVRSLISQQRVDVTTLRDIEEALKGFTYYAKTLAPGISKRVNAIAIVDLKLNYKLAELLSDAERCLQIIDSAMSFPHEIDHVEPTGMDAIDSLFRRSESCMKSVKQHLLLRDRKQVDEAAFQLLKAIAEEYMTVPQFEDPNGNSVANRGSLTACIRKHLESKADSIPNLVVNDHFVLLNAITDTPDHTILQTTETVVGNKRVRGYTSRRVTDELRNYRNKCAIAEANANQTLRHIVRSLAPHTQSIVICSHFLVVVQTLAGHAGMAVPKGWTVPSSPSTGELLLKKFTPAFLPHDDVIPLSLKLNGTHVLLGPNNSGRSTLIASVLGACICAQSGLYLPCASGSKVPKFTNIVYNSPLRYSGTGDVSPFEYNINAIEHVIAKADNRSLVLIDDLGAHLDALQATAFVAVVVQRLAQTGCTSIIATNVGSDFRGHVSNAHFSSIVTSNGNMLLSEARCLATPLKHAFENSAFLGQIQQEMDRYVNQSSSEIPAVNSHRYGRPNIDTSAVSQKKRACFEDLIREMPSALRDAADILCAAFEELSTSSIRSAVVHIAAGCMPPPILSNVPVTYAIIVPLTPTGKSHETELDTHADACFAEGEFSAAVYVGETGNLDVRLKAHRSKPLSTVDEYMGKTYMNHEPEMTAYLQAKSGLSPEKSSQLLNWQASHVLAAKMNTRSDAKVTERKLIKRLYNHQNKLVLLSQRDGVYREMSAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3R6</accession>
    <name>A0A061D3R6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767532.1">
        <property type="nucleotide sequence ID" value="XM_012912078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3R6"/>
    <dbReference type="STRING" id="5866.A0A061D3R6"/>
    <dbReference type="GeneID" id="24563887"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205040"/>
    <dbReference type="OMA" id="YTNWNNN"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF37">
        <property type="entry name" value="2',5'-PHOSPHODIESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="281"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="632" mass="72777" checksum="85CDBEA8025584D5" modified="2014-09-03" version="1">MPPIGYNYALVKASSDSDNITITLNWNGRELNLDRKKSETLNVTLARLKRSLQKNSNPLSKRQTNVIDVELCDQPTGKCEMWRKPKKTTDMCDTSIMESTIENSMSASLTAITTVVGDYSISFLTNMFKPIEEDKTLEEVIQNASFISVNDTLIQVHTNVFRVQEVRVGPRAMVGCPVSLHVESDGHWRNDVYVEWLDEKGCILHHGPIYVPTEDMEGRHIKARVSHKQLRWNVVNSNYCEVFDSPKNRWQQERIVAFNNAPVKNSLLHLQSKQGGIRVMSFNILSPTYVSNEEAIDRFFPYCSPEWLDSSFRNPLILREILLVNPQVICLQECSTSAYREYMEPILSQNYHAWLTIKNQASDEGCCMFLQKGVFDVLEVQGISFKEEIIKPEYRGVLTRIGAANWLNYDPDTYFNRYHTIFQMCCVRNKLDDGGGVLFLANTHLYFHPHGRHIRLLQAYVLLNELERFKRQCGNKHSFDVNVESSTIICGDFNSFNTEGTFQIITNGWVPYDHEDFDYGLKFGYERFNPNEHNAKFPRGRKEENASRRSDSEERLEVPNCTGYQDSYGGEELPFTNFVKTFSGTLDYIFHSKNLQVKRCMPGISQEDAEEFEGLPSKLYPSDHISIAVDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3T2</accession>
    <name>A0A061D3T2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767552.1">
        <property type="nucleotide sequence ID" value="XM_012912098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3T2"/>
    <dbReference type="GeneID" id="24563907"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205240"/>
    <dbReference type="OrthoDB" id="366452at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="361" mass="41259" checksum="AB6AAFA869816E97" modified="2014-09-03" version="1">MYDREASFAKSYIVNPSKSTSGQTQRYTPPNVHESVGMNVVAHGQGNARPPQNAHTGDVSVTDTMEIPTIKNTNTKWMTMQRLQGETTVAKRSDSQNIYNHISAVKSTGSHGFSNSVGSGMESPQKKYEADAQHESVTTMKTCVFYIDIKWKPVQPDQMLHFEFGISGDIYRQLFLFITNLLPPTGVRDIPSKSGFQACERYDSLMVMKDKLDISNDTMSDTNVLCMLEKLRTLKCAICKNGGRRKVLRKSYPERKCAIYSTSTKHELHCYFGSNIVDQKSRLLLYHKVICDREPVFICGKEDRNCKAVMERLYDLYLEIAEWRIQVVLRRLTNLRESTFQVSFGINARDMIDFIMFIFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3X4</accession>
    <name>A0A061D3X4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-SNARE protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0205790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767607.1">
        <property type="nucleotide sequence ID" value="XM_012912153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3X4"/>
    <dbReference type="STRING" id="5866.A0A061D3X4"/>
    <dbReference type="GeneID" id="24563962"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205790"/>
    <dbReference type="OMA" id="DNGNRMM"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="25051" checksum="49D4E247C54329E9" modified="2014-09-03" version="1">MAIYQCEDELDRLLLQLKASLHNFEQLDEQQQSDRFSEALLLIERAKVAEVNYQQEIDVLKAQTKQSHLMRLHEKQQKFKELKDKLAELRTVVEQNELNQFEKLKESGHLTHAQKLIAWGDDIQDKTQSSINRMRTLTITSEKLGAEVTQDLERQTESLYRVGRTINAVEENVVTANATLKQIAKGILRERLVQILIALTVLMAIATVLLIVYRGNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D455</accession>
    <name>A0A061D455_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765945.1">
        <property type="nucleotide sequence ID" value="XM_012910491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D455"/>
    <dbReference type="STRING" id="5866.A0A061D455"/>
    <dbReference type="GeneID" id="24562300"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100880"/>
    <dbReference type="OMA" id="EINEQRM"/>
    <dbReference type="OrthoDB" id="364750at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="74015" checksum="465FFC7F00BFECA4" modified="2014-09-03" version="1">MTNGYVGGIPLPVEKSAGYDFGSMDDADGIKRAVHSPEAPHSARMKGDRRVLEELQKEARELLSLSYGLRAEAEDAGNGGLDSYRSGSAPSRPPSLISSPRLNLNPQTKQAIESKWAQDSPRKACKLLPTPEMSKACKTDKLLDVRPDSGRMERNTGDFTSLDVLDPVPHLEKRVSYPLDLSVRDICGSSPLVANATREGYREMLTALQQKYTVVLRMFDEINEQRMSYIEGLHELQGHLDNARSVMQLQKAEIAKLNGRAQHHEAAARQVAKDLERCHEALSVRMRHEAQLEAQVREKDEFIQDLMSETETLKASVGTLNERIRSLSFMPELAGNAEFAGMSYTYGDAVMELQELINKLSTCDLAQSEFDGMVETLQQKTGALRYLETLIKCPLTSNLADFYRQRFILADRFKDEVLKIHEDKEKELERNYERTQQLIDTYAARVHQANADSLSARTLLETYVRRTTMCAAPPVSTSKVAARVAKALRAPVEVMIAERPLVGAPHFRTTYVRVTDDALNFCRVKAEKLSVKSSVPLKDIRKLEFGYNSASYIFNHNLVKPGEAFPWHFFTLVTAKREYNMLCTDDTMMDVIYIGINHRIAGQCFMVNVVDISRMRLLRAKTKLHWHCQTHNITPRRMWLNAIRKTVESQTAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4F4</accession>
    <name>A0A061D4F4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765995.1">
        <property type="nucleotide sequence ID" value="XM_012910541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4F4"/>
    <dbReference type="GeneID" id="24562350"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101380"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="9593" checksum="5AB8EC74CF108B14" modified="2014-09-03" version="1">MRVLLLDGSVYSKGEVHKEGRKHCVNVVPVFSSARLSHSSCPRCHLHVAIPAGTKSYLQASFTLRIMVFRRKILCTILTASTKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4L2</accession>
    <name>A0A061D4L2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L18, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0206710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767699.1">
        <property type="nucleotide sequence ID" value="XM_012912245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4L2"/>
    <dbReference type="STRING" id="5866.A0A061D4L2"/>
    <dbReference type="GeneID" id="24564054"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206710"/>
    <dbReference type="OMA" id="KKQMYAT"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595798" evidence="4">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="203" mass="22962" checksum="403E906E55CC712F" modified="2014-09-03" version="1">MHLFARSITVVTYLLGVCSAFKVPGRVNVGGNGLIPSSCRGWNLHSSIRSTFNGHPNPRKLHKRPFWADMFDEEVEIEPLGPPCPKLLDDVVRGERRLRLTLKRSHRQMCATIVDDVARHVHCFMSTNFRYLGHIFGQEPTKDPKIMRNKGGNVRAAYELGKLIGRQARQKGISRVVFDRAGYRYHGRVEALAIGARKVGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4L6</accession>
    <name>A0A061D4L6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766070.1">
        <property type="nucleotide sequence ID" value="XM_012910616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4L6"/>
    <dbReference type="GeneID" id="24562425"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102130"/>
    <dbReference type="OrthoDB" id="434319at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="542" mass="60793" checksum="845841E1B196E021" modified="2014-09-03" version="1">MEIRVARWPLGPRAFVVAKRFYNPPTTPKSDIRAARKSWSKQHPDFRTRRPLVEPYNLGRLHPEKEWWKLPRKGLSPQTFMGFPDVAHIEKRGGALYTHLMDGHTLCMVVYRCIDKDVRDFGIWRSLAQQALNLAMGLDPYIVSLLFLYFSRSDHYDYRFVATFTGRILATLSQFKLHECYNVLLAMENEQYLHELTKQRVTRHAEALCLGDARSIPVEDALRMITVARANTPEVDNILLALGEIVEVSDISTVDEGIVVDALDAVCGMAGRVDRLCVGKLFDEVCARLEESSDCNHSRNIALLRALATFKYRRPLAIELIQERLRDNAHTANTVELCRYMSLAAEAARGQHSAAVPLKLSVANVRAEAMKAADKLLGDRSLATQFLIGCLGSSRPFEDILENVALLQPADVLRLYEAIAHARADLDPDVTEGVERFVKHAWGLSPQMTATEAARLMRCGRLDVDSAVGADMLHDTFHRVMSEMEALPADSKAALLDFCSSQVIRDRRERFAKKILAKLEAEPASVPRNAAAAAAVLDIYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4T4</accession>
    <name>A0A061D4T4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767243.1">
        <property type="nucleotide sequence ID" value="XM_012911789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4T4"/>
    <dbReference type="STRING" id="5866.A0A061D4T4"/>
    <dbReference type="GeneID" id="24563598"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202140"/>
    <dbReference type="OMA" id="LATYMIY"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="194"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="340"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="593" mass="66152" checksum="894A5CA5FFD6F902" modified="2014-09-03" version="1">MGAPQRALLAAAVAAVYAFTAAFPVAEARLERRPTGGKHLPVPLRSDAPRLHSAFFARDPLKLPQNVTPPSGADAHLPERAIFGPLSNDVVKKAAVVTGTVALTTALGYAYVRRVLWHHLYGKYIREDAPGIADALGHVLYTKDDPGRVALRRRSLFDVLAALLLAPLERCPWIRGLLKTNIRRIPIGEAIEEGSVTALYFHSNNVHRMLQDKGYRDFTKNLKQIQETMKESGRKFQVVYVNVDRKQVDGVDHFRDMPWYALPFDDKERVAHLCQLYDITGIPSVVLLNSDGSVINDRALYLMANKPNNFPWKVESPLDLIPDTLVNGNNQAVPKASLEGKIVALYFGAGWTRSSKEFSEKLQEFHRAVGEKTDGKFEVVYVSNDKNQADFEKELFDHNGNWLAVPFEDADSRLILQQYLKVPMVPAVVLLDPSGNVITADGRFYVEADRAANALPYASYLNRHGQQLVEDVAVNVDAFAHQPVVIVFADDVDPATQQVVESQLAEAAMQHANHRKGRQMKFFISKTADKRSGAVRSICGVDKNAKPQAVVLDLLAQKVYYDPKLTNVDQNSLLALVDDFYNNRLRKRAVTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Y3</accession>
    <name>A0A061D4Y3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766205.1">
        <property type="nucleotide sequence ID" value="XM_012910751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Y3"/>
    <dbReference type="GeneID" id="24562560"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103360"/>
    <dbReference type="OrthoDB" id="10574323at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595979" evidence="1">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="260" mass="28565" checksum="741B747B14990CDA" modified="2014-09-03" version="1">MFLSRTPLTFAVAAAAFLGASLVEATTTTDEATTPLYVCNDPNDSLCLFCRRYAKAPHEAEPFPSTFELKSRLVDHLKAKLKAVGATVMEEVSRGTGVASAQMEKICDGVSFIAHYVIALDVTSASPLSKAVRRYMHCLHQGASRHVKEFHNIVTKENVTNLKAVQAKLRRKLLAVESITTVDLGDVMGSRRCHDLLSQMESCCATYVLRQGDIDVSQQGRTDTIRSPYTCSRLEVAFSVTSNAAAHIREQRRALCSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D533</accession>
    <name>A0A061D533_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosducin thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767343.1">
        <property type="nucleotide sequence ID" value="XM_012911889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D533"/>
    <dbReference type="STRING" id="5866.A0A061D533"/>
    <dbReference type="GeneID" id="24563698"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203140"/>
    <dbReference type="OMA" id="NITTEWD"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33546" checksum="764699947E9187C6" modified="2014-09-03" version="1">MSTTHPTNITTEWDDLQRKHGNLPKIEIPETNEVRDARLVEVAEHELMREARLEAWKKKVQSRKQVTFGVPVTITADNFIREVTNASKATDCASKEDSDDGDGPQEGCGPNAAPSQPDLLSTAGQYIPVLLTDDRKESVYLRDAWNELARRHPTVKFAIGNADRVLRAEGKAVKAPSSILLYFGGKCIMQKPALSIFQGLTYDISGDKVECRIASSLEILLNSVSGHGAFLRQQINCSTSDSDSSSDNEDDRAFRSAGKAFQRDFLSQITGGKSRVRRESDSESDRDVGKTYTSWVFDRAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D536</accession>
    <name>A0A061D536_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GCC2 and GCC3 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0208320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767864.1">
        <property type="nucleotide sequence ID" value="XM_012912410.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D536"/>
    <dbReference type="GeneID" id="24564219"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208320"/>
    <dbReference type="OMA" id="HACPLEY"/>
    <dbReference type="OrthoDB" id="410989at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056048">
        <property type="entry name" value="CRMPA/B-like_DUF7631"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967:SF2">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24634">
        <property type="entry name" value="DUF7631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2680"/>
            <end position="2700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2737"/>
            <end position="2759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2798"/>
            <end position="2821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2876"/>
            <end position="2897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2909"/>
            <end position="2928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2934"/>
            <end position="2960"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="3">
        <location>
            <begin position="1488"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="3">
        <location>
            <begin position="1850"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="3">
        <location>
            <begin position="2094"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7631" evidence="4">
        <location>
            <begin position="2439"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="3239" mass="365973" checksum="3DA52BA1B6EFAFD9" modified="2014-09-03" version="1">MPEKRIPPVIISKKCTPDTIVDPYMTETGLPTDVEYGDDGVATIVWSLSDEGTGMDVGDILRLCWCGFSTGNSIQCTNSGFSIEAGRLFVVPAADTTIHCYAGAMCSTFVEHTDRPPMRYFLSKDGRITGSLYFTHTTIFFQKTLYMVEGKSLVHLQGYMTYREGISGRYYLSTLHKNSENAGALIFDKVDQRFRVNVPLLKRDRYYLPIFSQTVIKLKAQSCGMANLNTANARYEVGGFKLGSGVLASEPDICWCKPYKNVNCTKSEDYKIRAGKVFASGFVKLQYLVCDVKSFCEIRLRYLFYYQLIRESDSLLPANSIISIQKNGCKVIPNDPNILEHCESSNREVIDNLHDIFTASIDLHFVGVLKHDKPGKYAVCYIDKDKNKIAKVSDINLRGIYEQPRSVAIYLGKPFPVTLRGHHMRGVVGFLSTDAECRKKARDERFDVEMTESPDSTVTTKNITLMIWNNVVIIRNATGRSVSTKNTRPDIVTYHMCVSTGYGIHKTGLSYTLLGPNVLHKSAFDGPRGFVNIPNLLRLNGRNHLLVVTFLYQPSKIESCESNDWVNNAERLTFSVYHYNRKDAEITLFPTLLYSANTYICWCIADACTTLSNFRVSLYIPPDIEELQFQTIMAHDLPRKASISGYYNTFLDRIKFVDSVDKCGATNTILPKGLFSNSGITTLSDERVTYDSMRIIGHAFLRTPSEIKIGDTFKWYTQLIPPLDEDMFRELRVRLCYCSFLANNSCEHDADYTDWVGAIVNLEKRATTNEMILRLSTYSADIDRSFVPCDPDAPVKSVDTAYYRVRETSNGIGGILMSYLKEFRKNRQGFFIEICRRHVNKNSDKQHHYEQVFGSMRAGFYGMQKLYFMAEQPQEVVIFGCNVRGNRVAEFLAVKPYANCSTLTSANVVARSRIVRRTDRNSIIFSNIKINEAGTYKLCLRYRSRISGLAANKKDKSVVSKDVSEKSEMQQPVSTPNPLNNEAKPSSKVDVGGTQKGVTSDIVTSSPASTKPNLNTVNGTLSEENAEDEILYEMGGIIKVVDYRVFCIADVVAMAFNGFEGKPLETSIRHYSTNCVGEWYENFSLVGVLPHSRVLVLADCTNITYAMQIPDDVDFTAAAAGLHAAPASDAKINELPLWARNVWVVFPVHSEMEQVWITCKEFKNYQIILFLGATYVYGFSMPLRQELPAPKFVFKHQLLNPMDITYARNMVIISDEFTRTLRSFPPINISDDKLVSTVLRSGCYHNALYYMHREKGRGELYALDASDNTLKRYAFSDYNQRLELDERYNGIKGNGGVAASPIYAASSLDGYIVPLKTKQQEVLIIGESTTGRMLVLKADEYDTLVYKEINTNSQLHFLNVYSNGWIMLSMSRFYQGQMRNCLLNRTIGSYVTLSFQYNLMTTYLIGNMIQLDPVLHGDSFDAFEEDDEIHDDRISLKDSGLNVDYHTGTIRGVVKFNDCNYISIKGGNFLRTTTHTFLMCSICPPSHFFNKETVTCEQCTIGTYRNEERTDSCFRCSDFRENSTTLTIGGRTSADCLCDKQFYLKDGKCVPCAEATFKDTVSNAECTGTCGPNRSSILRIVDGKPEHVCLCNAMFYDFRLALDKLESFPEDFKQTIGMGPECVGKDAQNLHCTLPSADECVPCPVGYYCLGQEALPQRCKDGSTTQDTLSSSPASCVCAAGHGYCAYKGCIPCTGFGYKDTIDNSRCKACHSAKHVSSLLPPLPSPGPIRVVTEAEWDHELQVYRRMHPTEYKTLLSLLESSSLFANSETAGRSDDCKYCVGGTFFDINLKICLECPHGRFCPGADAQPSSCGSNGITRHPGSMTAMDCYCARGYGNLFLGRHPTSGAIWCRHCVVGYFQHLEYADYGCLPCPENSSTSDFGAKSIVDCSPDPGYFLSVTKVNRVNGEESSILQDEGKSMEASIAGNRQNMRSKCFDAIRTDITARHQAILLRDSPASCQTSCVENVFCHGYSFETTTQFMESDVAPFKAYQTVVFNGLRFLKRPYGLCTLYFFDLKFQDLTGSVLKNISAGDVISVCRVFDEDFEYRFATKPCPIGHYCHGGIDYMRCPDNSTTIAEGAFALNHCLCLAGYEMSNTSAGVCVPCELGTYKQEIGNVGCRRCPDKFRTFNKASKYITDCACSPGHFAKVTKHHNDMISEATYKRMRDRTILRSSHLEELNYFQFRQQEEQQRLRSINRRGNSHILDLPVDDSDPRYQIESFIHLSNAVLLLPSVGQSMVSAFDTHYETFDCERCKDYHYCPGGWISKLPEKKIHNIPYRCPQGSNVPAEATNATSVTQCLCLPGYRLKTHVHEMPPDVYEGKYPNDALYYPDSGETLGLPDDIAALSGENSENTGVSWLGDKLPSASAQSLLEHATRRTTVHVQCVMCEAGMYKEGQENSTCSGRCMQYATTYGGAVSQKQCFCNYGRYMSFEDTLGSMQLTCSPCMKGAVCPGGLSTEVVNSLKSKRDFTEIQLRDHRMPMARYGYFGAFKDQGVELWSPLLHSKTSLHGVSTEQMDYHACPLEYTCAGMDGFPCISGSTGYLCMNCVEGYERIHFRGRCIACDDITESVIRYVATKWPLWVVASLMVFLLQKKMFYQFVLLKIWLEFCFSMVPYSMFPLNSQSSISRFASYYNTIFGYQQQLFTVFRIRCWVHAHSNYRFSNVESWYIQRFMSVVQPFVDGLVLFLILLVLWILYAPIRSLRRRLLRRYTSISSTSSSVSSYDVNPAAQRKRARCCWPCGLFMHCLSALYYVSFQFICQDLIQPLWCVPIQYKVEPPISVLLYLPTHVCDLNDPLFYYPTIASSVLLGLVIVAHLVAIITSVHVCKARRIYSCGRQKHTLSWDCLLLLRRVCVAMITIFQPQTMSTGSAEKMRMLGSVLITSILLIAHMSMLPFQMRDDNLFNRMELMSLMFNCFTGFFILGSFSYDLHYSGLAPLFASLFYTCVMLWYSLVECGFIADLRPALRRRIGCLPNFWNVCRKLLTWHCHSQITFDYDQGYLVIEMPFSGHVRTRRSALFAGRRRQKVSVHGRRSLCLCVEQSVSRYVMEQKHFQVPLYWEEFLIRYSFAYKALNRRLRSSNVVSANLRVTDMFHPDIFDAGPINPWQLSIAILNVPLSTLVSCYKDFERGKLGALYELRCRYEELSSGATEALAHNTSAVPEMIQDVHILDTLRARTKRLQGELAMHIRNAREGKRVTLAVQQIGQGLEDFDDLLTNEEILEKIEALRREQQVLRNSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D538</accession>
    <name>A0A061D538_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0203190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767348.1">
        <property type="nucleotide sequence ID" value="XM_012911894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D538"/>
    <dbReference type="STRING" id="5866.A0A061D538"/>
    <dbReference type="GeneID" id="24563703"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203190"/>
    <dbReference type="OMA" id="LPNDNIC"/>
    <dbReference type="OrthoDB" id="271910at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="6">
        <location>
            <begin position="326"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="462" mass="52452" checksum="B79767A96086032F" modified="2014-09-03" version="1">MTREKVATRTDGDESISSPVVNDCSVEHPGIATTAPPQGAESSSTHRPNEDSHDVAGELREELEMAGCQKVYRTPSGPNPGAQQALTNVVMTVEYDGSEYNGFVGPNHFYNDERLAMTAENLNTESQRHTSANKSVSNEVLRAIAVIHGYIPNRRKRKKQTTAVNVDEEAVYDVDDDVCTYTLPAERRFTLVASSRTDKGVHATETACQYISFDREPPFNGDLDAFMDRVNRILPEDIRVTAMIAAPKPEFNVRFDNIGKCYTYKVDLSECPSLFERKHHWQIVADSQFRNTLLKSRFIFHSTGKHIREEYNEVREQFSFDRVREAADVIQGTHNFEGFRKKSRGNEKMITKNPICTIHRIDIQRNDTEVGQNKFQFVIHGDRFLYKMVGYGVLKVDDIRLMLERGEAIPDIPYAPSNGLYLTKVKFQPGVEAAIAESKERRCQRLRSLLKPLVEHRGNTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D539</accession>
    <name>A0A061D539_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase 4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0103940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766270.1">
        <property type="nucleotide sequence ID" value="XM_012910816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D539"/>
    <dbReference type="STRING" id="5866.A0A061D539"/>
    <dbReference type="GeneID" id="24562625"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103940"/>
    <dbReference type="OMA" id="NFIKHCA"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="4">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="288"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="514" mass="57476" checksum="83EEE1D9C40F207B" modified="2014-09-03" version="1">MGGSKHRHSKDKLYLLHTELESSLDPKLRARAGELLSLDACSLSLQPFSKPVCSPQGHVFDDSNIREYITLHGSNPVNGEPLQINQLVELHFTRDENNELQCPLSFKRFTPSSHVVAVLASGYVYGHAALKDIAKKQKDGTMSDPMTGVPFTKADVVTLQDPHNTEWRKIANFKHIATTFARSGDAKGEIRGNALYRSTIDKFDGATDLVENHAKIFNAANKDDLADRPKHARFTTSGQASSFTCTAINASYATQYRPMTVFEVREPLYAMVKKQKLKAYVKLVTSDGDLNFVLHADRVPMTCDNFLQHCEDGYYNNTIFHRCIPNFIIQGGDPTGTGGGGESAFHTRAKRNNPNEEVPKYFKDEFDNTLFHLGAGVLSMANKGKHTNGSQFFITFNTCDHLDHRHTVFGKLVGGMDVLKKWVNLKVDDDERPKQPPKIIKAVICSNPFDTVAQQLREEEQREATNKKRRLSSTTRNWIINPQLQLQSAGATENKQVGHLLDKKLKVDKKGAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D553</accession>
    <name>A0A061D553_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0208520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767884.1">
        <property type="nucleotide sequence ID" value="XM_012912430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D553"/>
    <dbReference type="STRING" id="5866.A0A061D553"/>
    <dbReference type="GeneID" id="24564239"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208520"/>
    <dbReference type="OMA" id="KLPYPVF"/>
    <dbReference type="OrthoDB" id="328978at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600614" evidence="2">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="283" mass="31836" checksum="A82E33B4F3DB3159" modified="2014-09-03" version="1">MSSHPVRLLHIAIFCSLLASSLRPVYGLADTIAHNPSSVEGKVGTLSSSIFGEDYLREVESLLRDTYGEREVEFFRRMISDFDRRHVDDEALFLDDAALESHVSGDIGEHFPHEYAENDSSATDYDRRKARALVVLIKEQFRALDEVHSTYVKPHLTRFSQIRELSKQESIYTDTPCSTQAGCDRLEMLVNLCSAIRGGSHLAYEIFVIMVHVLATMMAVLCGCLFTGPVRICFLQNFPYTCRIPYPVFSGLFQATTSVWQVVKVVTNICRIYGDPGFGSIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5H4</accession>
    <name>A0A061D5H4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0209410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767974.1">
        <property type="nucleotide sequence ID" value="XM_012912520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5H4"/>
    <dbReference type="GeneID" id="24564329"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209410"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="80" mass="9028" checksum="DA7271ADA8F0C7A1" modified="2014-09-03" version="1">MAYATRAMLSGRNMTSRDRMIGIMKLPRGVTGRMGEYTRGQRYFIPSKSLIRPPKGIPKLLKTFFTVHSVGVICLPRSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5M1</accession>
    <name>A0A061D5M1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0105630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766440.1">
        <property type="nucleotide sequence ID" value="XM_012910986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5M1"/>
    <dbReference type="STRING" id="5866.A0A061D5M1"/>
    <dbReference type="GeneID" id="24562795"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105630"/>
    <dbReference type="OMA" id="TFLMKLT"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="125" mass="13758" checksum="41109D46D7A6F5A1" modified="2014-09-03" version="1">MKLVRFLIKLANESVTVELKNGTVLTGTVMGVDISMNTHLKNVKIVNKDSGSGTEPNFVLLDHLTVRGNNIRYFILSDSLPLDTLLIDDAPKQKPSRVRPVIGRGRGRGRGGTGRMRGRYTGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5W4</accession>
    <name>A0A061D5W4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Suppressor Mra1 family domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0205650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767593.1">
        <property type="nucleotide sequence ID" value="XM_012912139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5W4"/>
    <dbReference type="STRING" id="5866.A0A061D5W4"/>
    <dbReference type="GeneID" id="24563948"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205650"/>
    <dbReference type="OMA" id="ECKFSND"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="200" mass="22450" checksum="A15F3A1BF3444A6E" modified="2014-09-03" version="1">MKSRQLVVVLEDATIINTQKESRVDILHQCLLVLLDSPLNKVTITVTTNHEHQSGLLKVLIRTEDNTLIDVSPHLRVPRTAKQFDSLLVHLMYKRQVKSQERDNVLMRVIKNNIEVALPPGSRRFGMSVGGRSVNLKEFCHQFAEVEYPVVFHVGAVSHSQPKGTVTQVEEVLSISNHGLTAAHVCAKLCSEFELLMQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Y2</accession>
    <name>A0A061D5Y2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768307.1">
        <property type="nucleotide sequence ID" value="XM_012912853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564662"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300260"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1709"/>
            <end position="1730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1771" mass="197802" checksum="25EDE71A0923D858" modified="2014-09-03" version="1">MAPQFKKLTDCPENLREAIDWLIQVRHGSGNGLGELAKALKKLIEEAIEKAYTTNLNALLKLLDPSKTYSCCKGKMIEIEKLKDSKNPENKHFNDLKTKCESIKNCYKSHLDDSQQKAYLDIVSKLDRLLKLKEGLTGLTDETQCKDLLTNLCTGLETFLGFNPSSKGYDGTGIVYSDLDRLCDAVMGFLKGVLESVKNENEVTTYDKYISEPNKRLNEVIKLLEEKIGSGRDGLAESVEKVKRWLEGYDKKLDEKTSEVTKHLDTLINEIDSDINDVQGLSTYRLFQQYDSCSLIATRMTGHIHLAEKDLKNVDSEMGDKLAPSMKSLHQAVNNFKKSADNKDIEELNKFAGSELDTLRCSVEGKVTHRIISVRETLQTEFQQKIEDPIKKVKTKLTSVDEDLKTWIQAAKKLLQGAVTAAGDVNTDLDPLTVEPALSVAATLVDTKIGTTGRKDSEFKKLDKEADEIYRSAYGIHSQLSGAVYGILSKLEKISEAIDMSTKAIGTVTASGGWGDTIEELHRALNTDLESQLNNLKKMNYNYGSYKDGREAFTNIFNAVKAQIEGLKELKNDKSTGGQSNKSEAMLKCLETITRVKAEFQEAVSVFKTRIMAISQTGGSRHVQDANASMQKLNEISKSVGEANSSIIKMLKAIQDDINANVDQIWKHNGGRAPEYVQATGAMKEVYKQVGAFQNDVLDKIGDGKKQNSDTLRGKLETSRNELHTLANQIKIKLATDIESKLGIIQTNIQKSVSAITSQLRTLRTTLQDQVINKIEKLKTSGLGPANDNWAETTSTAKGLAHIEANLKGIIGNSDGSQPETVEGIIKKAGEFFQKINDEADKAFKEINEYVAKEVGTTTTNVRNKAQRIYANRIQKEVEKLKSIVNTQKSEIRNIVDKDRASGIKCLLWNMKNNHDTLTQCAGIHELKWTADKLRHYLDPLLDYILQQSMTPPLYPTGHVKHNANSDNVEKLKKKLDNLLTKLHESNHFDRTFSDNLAALKQQLTTFPPSSFSGIFNGVLLDGLRAGLDGLCSQLCYSYVNRYSGLKFEGELRKNLHNVLQPGKVYEKYDLTEEGKNCAKVCLTVFSTLFNDLSHLKERCNGGWRFRTINTTNKLGIFFETRGYIVPKNADNQNAELNRTKKGESIMTSAMKLFNVRGAGYLEQCHHCLETYYQVCHISTFAAKKRPCNIYEILCWLSGLPCNAVYDTLLQSALSDPFEDSNKPSDDFDGTPVFDLGSSKIEAYPQAITYEDTRNALIHVCSQSYDLLTTILGTGDAATFYASDFSNNSMQFHYPTSGEDCLDMLSDILRRLLPQLQFLHSKCRESAKHHGWRECLYGKHIPTTKWQCTDYATGKATCQPKDQPCCQATCQAKCQPNCQPMSPLMSYLNDCLPGHLPHQLTKLGCKYECATCPTTSKLGMPCMTPLGFRQFSSSVRTGNDICNVISKLLSNSHIARLLCLSPKAPSTLPEHFGFALTLAKGLSAASPRRVDSVVTFADSFATSITKGSIKLYDETSKLTIPLRNAYGDGESAHGDRHNEATKADLSSLAMTQSCVLPNKHLYCAPYLKSLCGDNYYYLAQKDSATYLSWAIYSPWTLYRFLNCLYDAFCNISCKDWGCPSCVPADSCKKGQHGVGNSCRCNSLVGCRGVLSTFYNYGFTFGNATSLLDINNKRYCRNFQAQLKNVLDSEYFRKLFEKCDEFLWIIRQPFSYLVLALWLLSLLYLLHIMVVRLDLLHIKSHLHSPSSHRIAAQSLLAAARLGKLAKISYLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D691</accession>
    <name>A0A061D691_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766630.1">
        <property type="nucleotide sequence ID" value="XM_012911176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D691"/>
    <dbReference type="GeneID" id="24562985"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107420"/>
    <dbReference type="OMA" id="IMDKYYI"/>
    <dbReference type="OrthoDB" id="364970at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="813" mass="88277" checksum="DE5FFA6891A8D7FA" modified="2014-09-03" version="1">MLDEHDLELLCSGDQSLNWLLNRHCLYASSPDGVTADTVTGVHSPKTGEPHAPSSDIDAMGLGSPSSAYVDVYGSQTALPVHTRHDAGSPADGARRDAAPSLEDLLQRLDSLNTALWRQADTLQREANGKLEKLTAVVRSSSSAGAPLDVTELASSLHQCEEVVDSISHKHMKLRDLHTLDYLHRVLTLNMSAVSLIHNWDDTLRAIQGSLQSFERFREKGGLLTGMLLSDDAAAGFTYANATALRDIFMRLHSTVERCFLNDPNFGHMSGTLESLRLKYSELVSDICYDVCTFFFSPFETSDVPSPELSAEAFRRLVELAAGVFRPSYTETLLAQCFRRVLDGLLNSQFFGIWEEHASNLPGGSDLALLPDDVGVIVSSCAATMNAFYDLLVRLVTEHMALFKGFFAAMGARNVCANPDAALNSCLRDVVHNALLYFEVFDETLARLPRAVFLTVATEVMTSAQPAADKLVEAFSALPFHAEICQMPVLPKGMLVRYLNALDELSAENCWRSAPAASSASLDDHIARLDQLVSYASGLKCASNGILSHGDDVAIYPPLAWIYNRLLLWRLRECYRAVMSGCSDSLSSYFTALGQREVGRDMDTETESDCRRVLLALAGGSGSMADVMDKSLAAAATPGQQQSVLPTAITQWCVAGGRMTSLDGVNASVRQCFGESFCADGRSFFHDESGAVSAAVTSIVRFIARKASGIMRNYANAAAEQESDTDVSSSVLLLSGYFTALLPVFADDDTLPSRILGQAFTVFVDEELEKLAGARPSEPARLQRYRADISQLLVICNYCGSDVGESLEMLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6B6</accession>
    <name>A0A061D6B6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768284.1">
        <property type="nucleotide sequence ID" value="XM_012912830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564639"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300030"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1796"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1858" mass="207553" checksum="7D9BFE18096B76D8" modified="2014-09-03" version="1">MGFLSGVLSNIKGHLGQHKGTLNDAIYTLNTNKHAGKKGFNAAIESVVAGVRGYNGNVKTSNDLVKTAIKKLQRDMKNYKKEELQTKLPNNINPKRPTASTQESVEKAMSLVEDCRKFAKDFITAVDIKTNKSETINAIKDLNPKLRDTIENVRKNLQHESKRLKELSSKESEKLKATEEKIKKALGDLKCNVNNRIDVQVNELVNHLRKLVKENILPKLQEVDTNLFKYVETLQEWITEADGILKIALEKVKKILQEVNWDDQTKFPRQIVQASDLMNILLQGNAEELQKWRDAAGSVVSAAKEKCKTIGGMVETGTAGSDKIHGLAKDMHDKAEKLRKAAQHIKDNIGTWVRTALTQVKDMDEALKGDLYKVKEAVDGQVTEIKTAIGKLYDKFDAYGRGLQNKEEDKKKVEEVIKHFKIQVAGIRGNAKGFRGSADGLAAIRKYVWEKYAEKFAGSKFEDEIVKGWIADIWDNNGMVKKWIKGYVEGNKHRRITGSVTYFKAEHIDNQNNIIQKNHTQKIAGIIMANLKDRISQATSNITAGEEQTSKMNLEYVRDMCTSFAQRIGEKIMESKFGSFASTIATEVDTTVRNEEVTSNDVDRVCLTNAVHAILAALYAKAKQAGDQLHKLLAECNLGYIDSAYNKATDFVEKLDKALNDTDGTNHAAAVDTAIDGVTSKLEEQLLKDAEKLASHVKLPTDDPKFQGYRGFVAQTEEALQSLKNGLKGTRDEGHLPAAIGEIKTNVTSKLTEKGLEAEINDRNTFTTPFDQITTKLKTIAGLVEKGKGTEATVPVGDADGIKNKLDALTTGLANGPLSTANGLQQIQESLKDLLTHTVPLVTLNLNELCNAVIDAAGHGRYQDGLNTKLSELKEMYFKQYKDGVTNAEKSINKIKDNLNKLRGPVTDALVAAKNFVEQDAADAEEHYTKELKKFINQDVEDAISSLTSHARQQYVDSIKLLLQAFAEKAQEELSPLPKLIDTDLTIGFKGFMKAVEGEVTEGETTGANIKKLSSLATDPVDSADKKTAFQNLSKNFKEFYINVHLYVKKEAVRLNEEENDKKHPAVKDVYDYHGQLIAIYDAFNELMAHIHRTHRYDHILPGMLDKVDAALSSLKPDGFAKPSSPVIDGLIAGLTHFIGEMRRVYISAYDSVTFGGELVRNLQSEKSELTKEGRNVAKAFLTLLATLFHDLDRLRGECRSLSKQKINQSTDLGRTMRGLGYSVSVDKQDGELQNKETVLGENVYKRILWPIKEADENEHLERCESRDHDRNDKFHLLDVLNCICSHVEEYNQVSHCATFAAKRQPCSVFEMLIWFAGLPYNNAYAELKSDGFTDLLDNPAKPLTDDDDIIVYDMDSFYIDACPRKFTYRNIRTVLHHICTKSYDILCAIGGHGDAGTIYGIDFCNNSFSMKYPQSGADCLQMFLDVLRRILPPLRYLFKRCGVKADQFGWSDCLYGRDIATGKSQCTEHSSDEPKCQPTSPLMSYLNDCLPGHLPHQVSAIGCKAECKTCPTSKPGMPCLTPLGFRGFSGSTRKGWDLYETLSYFFGTNLISSLLCVVTKPPSTLPEHFGFALSLVNKWHESGTHLIKDAFHSSTLSRSIGLYDQTATLTDALRNAYGSTQNGHPNREVKRADLSSLSTSTASAEQTAYTAPYLHSLCHDAYYYVAKKHVNAYLSWALYLPWDLHKYLENLHDALKNIFCRDWGCSTCLRADKCKRGEHGIIEGACKCSSVVSCKGILPTLYKYGFVFEDAKSLTASEKTCFAFIQQVQNVIRSAYFTELFDRCDEFIFTIRAPFLWMTVALWSLSLFYLLCVMVGRLDVLHIRSHLRIPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6V5</accession>
    <name>A0A061D6V5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SUPPRESSOR OF TY 6 (SPT6)-RELATED protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0303350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768617.1">
        <property type="nucleotide sequence ID" value="XM_012913163.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D6V5"/>
    <dbReference type="GeneID" id="24564972"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303350"/>
    <dbReference type="OMA" id="LDNEWIN"/>
    <dbReference type="OrthoDB" id="343921at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Helix-turn-helix DNA-binding" evidence="8">
        <location>
            <begin position="283"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription elongation factor Spt6 helix-hairpin-helix motif" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="domain" description="Spt6 SH2" evidence="6">
        <location>
            <begin position="1552"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="951"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1798" mass="207504" checksum="9CC14A6C3ED9A1B0" modified="2014-09-03" version="1">MSDSGAPDAAEAASELKRKRVSSIEDETEEEQPDAVDVPSKSPFKAARVESADYKSIRSKYLDTMAEESEEDAAAAADRESDSESDSDDEAELGSEIPDEMKGFIVDKVDDDEVSVESDVSDVEYDPDVLDDDDLALIAENTGAKFEQEDDDYGAKQLRRLKKGSAVAKRQEEYDNWLEDEYIEQGDLDLSDIWATVAECFGDVDLVVQILKNERTVQPREEAAVSDYESEYVEPATQEVTLESLADPDELAKEYMTKQDEAIREHDEPERLYIRYRNRPRHTDDREIKDEAQWIARRLISEFSDDLSVERVRKMYDLVFRGTYPSPQISPEEDIREKCEMVLVWLLNERWEVPFILHHKRHLICPPLTDDIVWRVYHLDAEWIKLKTMAERIKDIIDRIGYEELPNDVLYYALNFNTLEDLQDVNGHLRYHHRKAMYEETPVEDQPPEKPLQPAIPAEDPVPLEDGIMGDDIEDEDDVFGDFAFGGHTLETTADPQHFRSPSSVPISPMSAMSSPLDRMDDPAEPVHGDAGPRILPAKKTSIIPPDSPAEGDPFDETNQEFGSGDDENHDLSGRVAERGGGDNGDVDDEAQLDDDDDDDDTDHHADNREGLDMSADDMSDDEDVDMDVDGNQRSDHAPAHSTDLLEMDDDHLKDDYEEEDELPDHRITEIATSMKSLEVQTTTKRPHMKQRSVDMHLIDTIEKGGFHELWRGYIADARQFATVLEKSLTPGSTELRIQMDQVRAQWKELGAVGMLDAPSIIEGSEEQQVEDMCAQFCRPPYSGGKRLYTALVSYHTKMLAHDITIRRLLREYYRNYCSITCTTTTKGEAEVDVADASWPARRLYRMPLRELTTYRQVHYSYPTSATTREERYRILDSHRRGTALAEMYLQIVQLEKEGAIKCTIHPICAQEVPAWKADGFGDRFAEWYERYKVVTYSGNQLVSESYRTRMGEQKAILEKEEMLLKDAEERDKQWRRQLLDQLVMAYCPSNVPTYSIWRHIQKEILSRLINVELIPKFRMEIREELWRNAQSFVLLHCQRMLQYKLDVNPSPSETVLALAVDAEPQRVYATVVNEFGDMKDYKRLDRLIAHPIMPRNATPSNPLFKEVMEDIDVLCDMVANFRISVVLVAMSNTGAVTLYNRLETYMVPNIKVPLTIKKLDVEVPRLRVSMLPRASVNDLCLSMARWYIDPVAETLNLWSQNSTNLLLKLNLHPFQHVISQEKLQEYLECTLVHMVCHFGVDINRVKNSKHLEATLQFVAGLGPRKTMDVLRLLKIAAIGTRSQLRMGQAAIRGLGELVFYNCASFIKISSNEAMDILDTTRLHPVECYYTAEKLCTDSLDYDLGGEEAIQEIFNNPKRLDDLDLEAYSSLLMEKRSMPRMLPYLLFVKHELQSPFHDYRADLQELREEEEFCLALQIDHLLLRRGAHVMCRLEEVYEHTIRACVLPLELKAHVVDYRNFRDDVYRISKEQNRTIQLRGICISARVSNVEYAPNFENGRCAYRVEVALTGQQRRYLLLDLFDDVKRVLGIREDHLSPLVHFDVNYSKKPMLNEHSEKHKIHYRRVIRHPSYRMWPLNKIVAFLKQPEIGIGECCICPMSEWDRLNLVIKTCAEPFNCATFVIHERNQRVPGELGKELILLNQTYTSIDQIIAQFCETLKLNLEEIYMHPKFKHSTDISKAERDLIQESAMRPDGIAWAILPPHPMQHRGSQVRYNPLRFTLLVMPPSMELTQGARSLQDSIYVDHRSFKLWTHHEKSLASLIKWWKQVGYWNRNRHRELYNQEKAALMRQGAAPQMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6X0</accession>
    <name>A0A061D6X0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA helicase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0301820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768464.1">
        <property type="nucleotide sequence ID" value="XM_012913010.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D6X0"/>
    <dbReference type="GeneID" id="24564819"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301820"/>
    <dbReference type="OMA" id="KEYLCCN"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="965"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1190"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1553" mass="177474" checksum="FF705A90866EB65D" modified="2014-09-03" version="1">MQQSALSHFVGYLGESFDAEIRQRLEDAVEACQASALSVPKCAQRILGEFMAPLSKSFTLVEVMDPKTALDRELQVLYSADLAASYVILFCPLKVRHELYRYLWGRGAFLDGNVNWLCCPWVLNQGAHDAEYHKLAVDLKQLSDDELIDIIRLHKNYLSTDYVKQRSRNSLKRLDRHSLLSVFQSVMLRVLWGHEAISDGPKPRPSDDIINSPDDLERMAREFAGEKARKEEIRMNTLAGWLEHYRDNTRQKTHAENLKHRKLQLRETQYHGQMRRSLEVVTNHLKRFNETFRGAPGNMPFAQAARMYTSEKMPGIGQIGDHVTVEGIRRAFNMLIDFYRGNLASVSDIYGYLPGISSLRLLKFLLSYEKHDLMALLSAVLLALPEFRPIETHQDFAQYTLLPFKTVAKLCFVAIMRINPDISKVDVGVQLDDDEIRSNSHIWDESSVSRTPYDEIGSSSCETSPSQSEQSMSYSTSAKECQREDFFDIPGNKPSTAVDDDDDDGGDDEDDDDNDDYDDSQVAMIKGHIQTNGERVDNVASMVFTTDELKPIASYIDSKKSKIVDATLGGERNKCLMLNTRRSRLVTEAILMHLSNYDAVYEILKDRDIELPPQDETDATKEAIRKYKLAVVIKRATDSELEELYGKVLESSKMHEELRIPEDIYKLSSHCLLDRLEENVNDDDVYVRLCELLQRTEEEATAGSQQPRTQTEPDWGAENEATFTECKYDSDGPGYDTEASGTTITEREHYLNLLEGEDLAPFLDTTFSSDYPNLMTDSELKRLGDQVLKRMETSENCEIIHYDTSGKGTRPFNLYSLPVHVAQTGQQHAYRSGNGRARCGFRLFASRGGINAETAIPTGVGVEHDEKGVVEPSYGVGIFPKRMPDPKALSWQFPDAMPNYKLLRNRVSQDGVEPHVNPWQQLGLNSDVASAAVGWIRKCLLDSVGRSEQPGLEIQPTEIQSMAIKHMLQDSGDVALASNAASGKTLAYLLPVIQKLKEHEKLKLRHPNAPRALILVPSRELADQTLSVIKGLGHTVKISSEGVAGGRYKGRQRDHMKRLVDIVVATPERLLKMIKHVRLHKLQFLVLDEADTLLNEGFWPDIAKVLDYIKQPYRLVQVAASDKYLLHFEKVQRALAKVPNMRGVQNSTPERNAKYLERLTGCHQLVDKAWVDRPNRGVSHEFRYLKGEDKARELVNLLKYDSARRCSKVVVFCNSIPSCRAVEYILRDAGLPATSLHGKIPLMRRRQYYEDFNNSASGILVCSDLASRGLDFNADAVIMFDFPKNSMDYLKRCGRVGRMINNDGIAPRGYAISLVKKRDRNLAMAIERSVRMPFFPISNLSRHKKDYNQRSGRLRHLTQAGGYFKLAKLIRQKEIEGTYDYANMDQYLEEFKTNVREMYDSSLKKIVLRRRRICKRRRILVRRLRLMKRYNRAIRLKQRIISTADRNRRLRRFSAHAPMKDDDRRCPPLKDLKPIRAKILALKIMEDKMTRRLLERNDRRLRKFINKTQLTARAMAKPEEDAEEAVNRQLPFTIIERAKEMLGKKVKRICSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D707</accession>
    <name>A0A061D707_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0209300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767963.1">
        <property type="nucleotide sequence ID" value="XM_012912509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D707"/>
    <dbReference type="GeneID" id="24564318"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209300"/>
    <dbReference type="OrthoDB" id="10348007at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="259" mass="28858" checksum="F912E639BFA87DD3" modified="2014-09-03" version="1">MVYNSLTEAPHNLKEAVDWLIALKGTDAGNNLAALGEAVHKFLADKPVGSMKVAALEEVKLITKEFLKRPALKEMWPAQSVLRRFNEVINKEPKALHRWFGDVYDSDYKNIIQTKGLTPETIAQKLGKAVDGCEKFLDGITIPDQYESAYSSEATWDKSCSEKPEACAVVLVGIAPMFYVGLRSVKVACDDEASGAKGFLTMMSLGSVLLATGYEEKLWRAKLTTSHVSKALKDVSYQVLVTFYDIAGFWAFYWFENHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T7</accession>
    <name>A0A061D7T7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0211990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768243.1">
        <property type="nucleotide sequence ID" value="XM_012912789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7T7"/>
    <dbReference type="STRING" id="5866.A0A061D7T7"/>
    <dbReference type="GeneID" id="24564598"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211990"/>
    <dbReference type="OMA" id="MLGMWET"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="155"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="263"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="356" mass="39530" checksum="4873C599658CFE65" modified="2014-09-03" version="1">MSREATSVERCPEKGADPESGGAASKSSRNNSYVLCGMLSGVITKTICAPFDRIRLLYQVQPMFAQVNATGEQYSGAFKYQGVIRTAQKIIVEEGICGLWRGNMMNMMRGGLCYATKFGINDGAKEQLRTLGVLQRWFDLRVERSDNPVRTKAQNTVMLSLLSGASAGMLQKSLSYPLDVMSVRMALGVNTKVLSTNCTYNSIPDCFFKILRSEGIRGFFKGFFPTLCTGVPYVALQMSFFDFYKKKLTAACGFEKDQLNLKQVAFISSVAGSAAGFSALSIVFPGDTVRKRMMNNAISDEKRLYLNARHCVKYIFRNEGIMAFYYGLFPSLLKSLPSGALQFVMYEVLKHLMSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U5</accession>
    <name>A0A061D7U5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0101140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765971.1">
        <property type="nucleotide sequence ID" value="XM_012910517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7U5"/>
    <dbReference type="GeneID" id="24562326"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101140"/>
    <dbReference type="OMA" id="WINLWES"/>
    <dbReference type="OrthoDB" id="364878at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596065" description="CS domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="565"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR93785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="744" mass="83538" checksum="4D99B03852DF2479" modified="2014-09-03" version="1">MLLYLLAHVWAWRYVIFVGIRCADGFVLRRCPSLVLGRPKTNRLFAAPNDAQPPIPAAADKEVAEKLEKEIQDKIARYMAPMEANNIKGIDQKVLDRNFGELYSVENIKKREQRNARKVQLEPPEVPPTDKLPYFVNMQNPKNPLSAAHVDYVGDVIAHGQLDPRSTVLPHAVCVGVAEQQGAVAEDRHGHLGEETACEVKADSAAAQAGENVVVGGAPSSGAGVEPSPDLDNVRQGRSTPTGESEPENIERLSGGITMFKNTYEELLEGNRTTEFVGDPLDPYFEAAAQQASDDEAERVDSDEEELEKQVWYRTKPLRQLMPKEMADGWSVLPCGRIYKHLLRPSHEPPDKQRVPGQETYVSFGFKIADAFTGEILVEAADAESEGIVTQLKELSPPVQRMLASMKVGEQAEFVCPAIELGLDKLDREGMPPVEWVRVWMHTIMMHERGEKWWHLSPIEASKFPTAKPYEDRRTRMERINLKADELTKQIEHELENNPTSPLWDDVMQRLNEQQKASVVEHFDQKLEWQERRKCAEFSGSRGFGDTIKSTGQVKGYDVGRMSGGSGGCYTWHETPFFIYIAVPVVPGVRAEHVNFELGQTHLTLKVAGKTIIDDDITGPVVTDIATSWAMSEKAMDYEPLPPGHPELEDPVLKTDRDDDYHSIARDPAIIIALKKRDKVLGDWGTPFLKQSGVVRRVHQTVEFTLEPVELRSEFAARRLQRQQGIRLFHGLQHVETQTEHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7X0</accession>
    <name>A0A061D7X0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768829.1">
        <property type="nucleotide sequence ID" value="XM_012913375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7X0"/>
    <dbReference type="STRING" id="5866.A0A061D7X0"/>
    <dbReference type="GeneID" id="24565184"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305460"/>
    <dbReference type="OMA" id="MEYELNA"/>
    <dbReference type="OrthoDB" id="364858at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="523" mass="58395" checksum="4B231A78E2243A69" modified="2014-09-03" version="1">MEYELNASHTLLLKKIFILFRHVSSNVQIVATNNGLNLYALNGSNSAWLHIQLGRQFFRSIQLQEHDLREEDEEYETSQGKYWLVSTKNICQALSIVSPAGYRSQGYCAVFLKDVGQGDDNTVRTTVALEKLVIREEAEHGNVLSFVLSCAGEHIQRSAIISYEEQKLSVPDDIDWLNWHYLRIQPTILYKSINPYWSPFDDIAIAYDAKKDHVSLTIVKSSVKNTGRTKTRASRRAGISGKITINSSHFLKLKFDERVEPPKDITISLKELLSLSSFCESLKSPLSLLLRHAGDPVIVLFGEAVDLAENTTGQISIHQIIAEAAGQEYGDAYDSLFLSNQNKAWSGSLWLSSIQLENSNAEETTQIAESVKTFGATPAEYEPKTDPTPIPESFTASVVERVPEPVQERVIEPVKSPVRATPKAEPRDIYEEIFEEPSHEKTPTQETPAGFGNLSRQQRDLIYRTLALDFMPAAKLETVKGPNSNVGSTPIGGSEYESTLEGSLDSAPRERVETVYDQLAGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Y8</accession>
    <name>A0A061D7Y8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101390</name>
        <name evidence="2" type="ORF">BBBOND_0101560</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Bond</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765996.1">
        <property type="nucleotide sequence ID" value="XM_012910542.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766013.1">
        <property type="nucleotide sequence ID" value="XM_012910559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Y8"/>
    <dbReference type="GeneID" id="24562351"/>
    <dbReference type="GeneID" id="24562368"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101390"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101560"/>
    <dbReference type="OrthoDB" id="366520at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="186" mass="20996" checksum="BE8F004257A4ED87" modified="2014-09-03" version="1">MQLEVHHHPYVKELLTRYNVAMDSNLGFFDRAFKDIAISDYENVLQTQSIEPETIAKNLGKVVHSTEKFLDYIKRTRRYNRTYSLQATWASSCTHDPEVCAVVLVGIAPMLYAGLRCLIDAAADAFMEGPASIQEHSLISVLETLGYEGQPKRGKVRSSDIRSALSDVNKDVLNVLYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D1</accession>
    <name>A0A061D8D1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GHMP kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0103155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766181.1">
        <property type="nucleotide sequence ID" value="XM_012910727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8D1"/>
    <dbReference type="STRING" id="5866.A0A061D8D1"/>
    <dbReference type="GeneID" id="24562536"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103155"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103155"/>
    <dbReference type="OMA" id="HEFHYLY"/>
    <dbReference type="OrthoDB" id="365033at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527">
        <property type="entry name" value="4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="5">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="374" mass="40310" checksum="FCDE12EFB84C6535" modified="2014-09-03" version="1">MRKLVACLAFASHLGVPATFHQPHRNFVADEQQIRRLLGCETQSAGTDSLACGHAYAAADGFWDHQGVAFAKVNLTLQIDPDAQVSDPLLKLSSLMHKVAWGDQISIKRLGSEEAAAAARQFDATEDGDVLLLAGDPSDSNAAEAHAGVPCDDSNIVAKALRKARKPGERYVVLMRKRVPPGSGLGGGSADAGFVLRALRTTISPSDTLALGSDVGFMAHDADAAVVTGRGEDIAPVDRLGHDGHIYILVPDEHVSTAEVFRRARELLPTGSMYTRLMSYDDIAESVANFRGFRPFNVLERCVQNNGVKVLLDTLRGALPSSRVCMSGSGSACYVLDAADDDVRSVRERYGRNLLIVKTRLKRPHDNDADFSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D8</accession>
    <name>A0A061D8D8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769147.1">
        <property type="nucleotide sequence ID" value="XM_012913693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8D8"/>
    <dbReference type="GeneID" id="24565502"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308640"/>
    <dbReference type="OMA" id="VFNYDSK"/>
    <dbReference type="OrthoDB" id="360720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="43326" checksum="AF0F68543A4A9419" modified="2014-09-03" version="1">MEHVPTDNPDSTNGDVGQIVTKMVSWKDVTDDDLPYRASINPYTYEKCRKIYNHYFQDLERLGQLETTEETVNVRKDIDKKIKVGAKPLSGVRGIYYTRGTWRVQYRGRNREVVSCVFNYDSKDVLIATFDLAFRLLRRVIDLGRQIKTEDGMVITELTEERLLDLDRRSRLRSAKNESTGPRDVQSVPSKRIRRQRQDLYTENYNSDADDSDVEPRHSTVRKKSRPSASKSTHYSKTLPSHGRGPDTAGEGMTIPPNLGYYAGKLDSFERLFQSYNKFNTLELISYLIDESRMRNRQRSVANRQAALPQSSAAHETSVIEEESATERISMDGSSVSECVYDQDDIEVNADVEYYQHGDHGMCTMIAKPRTYVIRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J8</accession>
    <name>A0A061D8J8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769019.1">
        <property type="nucleotide sequence ID" value="XM_012913565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J8"/>
    <dbReference type="GeneID" id="24565374"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307370"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596096" evidence="1">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="85" mass="9044" checksum="68C44A376AB17EB7" modified="2014-09-03" version="1">MKINVATVFRALFFVLLSVVLHVQGKGRSFALGKARDHASGKSGAYKGLRYTSGHRGKTQSAVCDDNFYCPGAPTLAKLGAAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K2</accession>
    <name>A0A061D8K2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767425.1">
        <property type="nucleotide sequence ID" value="XM_012911971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8K2"/>
    <dbReference type="GeneID" id="24563780"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203970"/>
    <dbReference type="OMA" id="IWAGYYN"/>
    <dbReference type="OrthoDB" id="411182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595566" description="RAP domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="85229" checksum="C84BA93653260F33" modified="2014-09-03" version="1">MSHVTHLFKCILKASLLAPAGLRAGRKTPCLCLWVRQSRARFHDVSGHASAQAPASNVSWLPHGSPLSSAGVPEHENQDRSIYVNEVCMQTDQLLARCEDHEDLLVLLVTHRGVMYLHNLVTAIRMLQGFAERDRIERTQPDADDLFAGYKEVFSSNAYSADSHGDDGPALMNVSEGAATPTDDAYRQNEVNDSNEITYTMQPNQENRDNAQVAIRGTLQYDPEALTETQRGIVKKATEDILTHFTNPANRHYLSCRQHSRPVAEVIVRDERYDLLLHDLYENRNKLDVESACHIIIALDALEHRYFRLYNGILRHIMRLPLHRLEYDVAHTTGKLLLKACQCYVRAGFYDTPLYSKVCREIYKLPMEHTDGHASAEMVMDTLRIFAKVDVYDHAVFSRAATLLPRLPLTVNDLSHVAVAYAAHHNYSKMHDEVLVWIAKQIQERHNEFGTLELARCVHAFASMRLYFAPAYNCLSQRLIDELETATHVYTKTQLTIPQMAIVAYHGANFAQHAQETQALVRSLMTYLEEHIDALDEKSAIMLAFASCATNAHETNPYVLSFLLRKIGSGTVWEEYKYRVFAIWLYQVVRFPELTVNIPKRCITAGMREWLLRHGNGTQFGAEIQEMVHILQNDLGPIYMTTQLKNVTPQSTKRRASNQAPVVDAAYSDAIEAISALEISLDGGTLKIVVNETSCRNDPSKPIGVDLLIHNLLKGYGVQVHSVNFQHWRSMTHELKKSYLQDTLNDYLAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8P8</accession>
    <name>A0A061D8P8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0204370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767465.1">
        <property type="nucleotide sequence ID" value="XM_012912011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8P8"/>
    <dbReference type="STRING" id="5866.A0A061D8P8"/>
    <dbReference type="GeneID" id="24563820"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204370"/>
    <dbReference type="OMA" id="IHQPYSE"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="205" mass="22800" checksum="5B6E4A0CC35AE9FE" modified="2014-09-03" version="1">MLPFRQRLRLAKGDYDSKIDDFYVRSRTLFLNGELTDRAAHRLISALLRMNEQDPVKKVKFYINSPGGSVSAGMAIYDMLQSLQMPVETICVGQAASMGAFLLAGGTKGMRCAMPNSRIMIHQPLGGAHGQVSDIKIQANEILQIRQILNAHLSHFTGKPIDQIEIDCDRDNYMRPAEALEYGLIDHICKTRTSHIEVGPAVCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8V8</accession>
    <name>A0A061D8V8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769169.1">
        <property type="nucleotide sequence ID" value="XM_012913715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8V8"/>
    <dbReference type="STRING" id="5866.A0A061D8V8"/>
    <dbReference type="GeneID" id="24565524"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308860"/>
    <dbReference type="OrthoDB" id="365890at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="500" mass="55941" checksum="3F75A6C29BCDC5D6" modified="2014-09-03" version="1">MLQWLAGLKNQKHHGTLRQCVVKAFGVPHSDPSQLAIFINHAKITPTDLFDILQLTAMFAGSVLFAIAPNWKANVSSSTVKPKSSDQSEEPDCCALLCQLRDYAYACHYQLQFLKSQCNRDKLSGGWQDCHYGSDITSPNSPLQAFLTDGWDSTFKTHPFDPCNFCLKSRIRMGFRDGDLPSSQQTGATLSTILTPSCGGDDPLLTLCSYLNCLTRRTPRTTGELVSFFHNFGVELHDYGQKMLSSLGLSLTKSHPNCPDWDRLGDSDLGAVRDIRGSETLTTNHNHNYDHPRTLSTLVGCGDDSSNCPPNCSPITYRAYALYSQSFAHTYLSWAVYLPDRLWESLQTLHYELNKHDSSKCTSLYLCSTALPLLYTHGFTPPEGTSQLPLKCSDVIVKLQEIVNGGPIATLLTAMDNFLYGIREPFIFTLVALWSTALLVLANTMLYRLDVLHIRSHLIRTKASHHIDVKALLTKGRKMLSLYKDVDYFDEDPINQLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z5</accession>
    <name>A0A061D8Z5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M16 inactive domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767540.1">
        <property type="nucleotide sequence ID" value="XM_012912086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Z5"/>
    <dbReference type="STRING" id="5866.A0A061D8Z5"/>
    <dbReference type="GeneID" id="24563895"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205120"/>
    <dbReference type="OMA" id="NYLYYIR"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="1">
        <location>
            <begin position="629"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1172" mass="132193" checksum="F46F2FA318FE69FB" modified="2014-09-03" version="1">MSAQRSLPFHKIHIALSLASAGIISSICDARLILPVGIGAFHTAGRRICLPSDREYRVDGTLLKRYTGFKKTASSAEGLLFTNRTCKKKSHVPVPMSLVQTKDAMTVAGNLPGWAQKAFKIQHDAYEKIREAFIPELGVAAVIYKHKITGISIISLATDASSGKEICFDIIIPTPPSNDCGCPHILEHAVLEGSKKYPNKGGFSILLQGGFQSFVNAFTYKDRTSYLFASTNEKDFYITADFYMSAVFQPNVRHDPRIFRQEAWHYKVSKHDPVAHSDEDHGIILHDRHISYGGIVYSEMKKAYSDPLSRAQDYIYQGLYTNSYRFDSGGDPEHIVRLNHKELVDFYVTYYGPKTANIYFYGPDDVLKRLNFVDNFLKESKIIYKSDLHTATIDTANSQLYSEFYKELNGVIHGTFGATGCEGEDLLLTGWLLDPHDNSNANDTTKGRFEIDSVDALGMEVLEHLLVGTSESFLYKSLIKSGLGNKVVGSGLTNYFKQSSFVIGLAGVNCEKFNSKENARLTFEEVVMSTFQKIVNDGIKKEALNASLNYIEFQMRELNTGSFPKGLMLVNLMQSQSQYGKDPFAPLFFDSIINELKERLMKDPLYFPKLVERHFLQNKHKVTVHMEAINPNEFEKISNESTRHMLFKALGRLSRKEVDHMEGEYSRFKSECEEPEDRKISDNLPTLSLNDIERENELIPTTYYVLGSSLTYVEKPPMAPGNIMVLCHPIETQGIIYLDLAISLEDLTLDEIRYMDIFCSMLKEAGTYVISSEDLSYRISANLGGFAATFAFMPPANGRKHSKRQGALGYLYVRSKALKGKENDMIDIIVDVLKASNFGNMKKGLEIIRRKINQMETDLISEGHKFASRRLMKGFSVTDYATEVSSGYEYLQTLKKEIHPTAETDWSRVETKLENIRLKLLQSKNLIVNVTASADISKQWLEQDSGNLSRQLRSIFVSPHHVEPQKSWAAEIVENGDDCSHNEVIVAPTKVNFVGMGGPLFNEEPISGADDLVLHYLTSSYLWRQVRMSLGAYGVFCNLSTCGDIVFMSYADPNFNETLQVFKNVPNAIEEVLRTLEDKELLRQKIGKISSIDKPLSADSRGFLALNRVIRGETDADRQLYREDILDASVDCFTRLYGKMRSTNEWHKVCAVVSRTTAETLPKTFIQLNLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D906</accession>
    <name>A0A061D906_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hsp70-Hsp90 organising protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Stress-inducible protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0303610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90. Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Homodimer. Forms a complex composed of HOP and chaperones HSP70 and HSP90; the interaction is stronger in the absence of ATP. Interacts (via TPR 1, 2, 3, 7, 8 and 9 repeats) with HSP70 (via C-terminus); the interaction is direct and is stronger in the absence of ATP. Interacts (via TPR 4, 5 and 6 repeats) with HSP90 (via C-terminus); the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768643.1">
        <property type="nucleotide sequence ID" value="XM_012913189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D906"/>
    <dbReference type="STRING" id="5866.A0A061D906"/>
    <dbReference type="GeneID" id="24564998"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303610"/>
    <dbReference type="OMA" id="MYSAREN"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="12">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="12">
        <location>
            <begin position="497"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="548" mass="62180" checksum="62348BA52B61414F" modified="2014-09-03" version="1">MTDFKQLGNEAFKAGKFDEAVKHFTEAIKLNPSDGILYSNRSGAYASMNMYQEALADAQQCVTLKPDWPKGYSRKGLALYKLGKMEEAKKAYQEGLKIDPNNEPLKAGLREVDVSSDPQFMYLAATISQLVATNPKLQEYQRQDPSYTMTLCRVLTEMQSNPQNIQHLLMDPNPALRDGIMAYLGMAADIGQAAGFNEPPQPPKAEPPKETKPEPKEEPLTESQKKAQEFKDEGNKLYKQKKFVEALELYDKAVELDPNNLLLENNKAAAYLEMGDYEKCINTCKAAIERRYDVKADFLVISKIYNRLASCYTKMEDYDAALAAYQKSLLEDNNRVTRCAMKEVERLKEKKEREAYIDPQKAEEHREKGNEFFKKFQFPEAKKEYDEAIKRNPKDAKLYTNRAAALTKLTEYPSALADCNKAIEIDPTFVKAWARKGNLHVLLKEYSKALEAYDKGLAVDPNNQDCINGKYDCMAKIQAMSQSGTVDEEQYRQAMADPEVQQILGDPQFQIILKKLQENPASMNEYLRDPKVAKGIQKLMACGILRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D966</accession>
    <name>A0A061D966_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767635.1">
        <property type="nucleotide sequence ID" value="XM_012912181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D966"/>
    <dbReference type="GeneID" id="24563990"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206070"/>
    <dbReference type="OrthoDB" id="366342at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595930" evidence="1">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="318" mass="34662" checksum="7F0CECD834C7A65A" modified="2014-09-03" version="1">MKCVLSLAILAISQIRLIAAAPQQEAGREAQQQAVEASAKVQDIKYTDIFTSTEKRFTVVMKLMKDDGFKAELLTAVHGAISRSSNDLFQKWAEVLSAAYPQRFEGAVARSTLPSWLKSTAVKTNSDQANKVKEALTEVGKSVHTLLTQLFGEYAKKIETEKAEVPQGAASGVAGSSTGLALTQAAANTSDNDDLLNLRFVMTPFKDDLYALYNSIKDMPTSNDNDKTAIKTKVMEWVKEKVPSVEPIEAIDGHAVQGQLKKIIVTDTHLTDSVISIESYNQMDTDLTEAFEKCKNMNAASFGTIGLLLAAVLAFTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A9</accession>
    <name>A0A061D9A9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0206620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767690.1">
        <property type="nucleotide sequence ID" value="XM_012912236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A9"/>
    <dbReference type="GeneID" id="24564045"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206620"/>
    <dbReference type="OMA" id="NDFAYHF"/>
    <dbReference type="OrthoDB" id="365876at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="489" mass="56421" checksum="13C3CC1BBCBFAFD7" modified="2014-09-03" version="1">MLALDALNHKQPGLSDHQEVHKAQRLFGADNAVADRWKTYGKPKRESSSQAFFFMYQMKLLNTLGLVKSVCRPWGTLPHGNDFAYHFHKIATTNSIKLLQCYESVFRSIYDRFDAEAADPENATASLWAKVEDVDYFKIIYRLECMRNNKPFDNDSYNEVLEQTMHNVELQLEMEQTQERSNFDEVPTWGKFNWESKNRQYSLSGLDDETALPSDIDLDIAAAVHVADLADDEFDNSDLINTSTNAIEFAEGYLGEQSGERETSDGNHRPYNTRNQNDFDKLVMNVLSKQPRASQTVYNTRVNKTQRNASSESRVNTRQKAVSRRSALNSKDDEDFVTELPTRSTSARKRDEDSRRRRRRRSEPTVSNETYVKVPPSSKPEVPSDETHANRNINVVSASVSYDKRQQRFMAQWKTREGTKHSKSFYAKRYATPLMARKHAELYKMYILQHRGKVVQDVPEPTYEQLAAQNFQALDDINISDIAFLDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9D7</accession>
    <name>A0A061D9D7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BBBOND_0106190</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766496.1">
        <property type="nucleotide sequence ID" value="XM_012911042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9D7"/>
    <dbReference type="STRING" id="5866.A0A061D9D7"/>
    <dbReference type="GeneID" id="24562851"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106190"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="24">
        <location>
            <begin position="103"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="210"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="510"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="979"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDR94310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1071" mass="122166" checksum="6D42F0EDD1BCA9DB" modified="2014-09-03" version="1">MATPTQYQDAVNVQSLRTLDGVNCHEFFQRFSRTPVNVDSLREIIMFQTDADYTSRFERVDMDDCSSIMDSSRSQPKFAEVPVIRLYGVTRDQHSVLVNVRKFMPYFYVEKPHNFREEHIPLLMDFFNKHLMDQPAFKKTCRFVVNIKVVRIKPLMTYQPNGERDFLKITTTLPRMVAALRSFLESGVALPVMDLPGSGNTMRISFPRQVCEANLPYVLRFLLDANITGGCWLQLPEGTFTVEKNKSSHCSIEVTTDFENLKPMPIEGEWQSIGPIRTLSFDIECVKFTGPGFPNANNDPVIQIASVLHTHGDKLDTAQKFVFTLNECDALHGAHVLCFDREEDLLLAWKLFFTAVDPDFLTGYNIVNFDIPYLINRANALHLEKFTQLPRIARINTSVRDVIQSNNTLGTYENKEINVEGRIIFDVYDLVRRDHKLKSYTLNYVSFEFLKQQKEDVHHSTLSKLQLGSPADRRRIASYCLKDSVLPLQLIDKLLLLYNYVEMARVTFTPIKMLINRGQQIRVTMQIYSQCKLMGYAVPVVNAAQRGWSNEGTYEGGTVLDPQKGYHRNPIAVLDFQSLYPSIMIAHNLCYSTIVPPSDIARYSPDDLTSVPGHPGLHFIKAHVRKGMLPLIVEKLIEARKKTKEEMKTCTDPILKSVLDGRQLALKITTNSVYGYTGASTSGFLPCVEVATAITSFGRFMIVNTKEKIEKYFTLANGYEADAKVVYGDTDSVMINFGCKEISRAIELGVEAATKVTSEAVKPITLVFEKVYLPLLLLAKKRYAGLYYTNAKTYDKIDCKGIETVRRDFCLLVQQMMEKILHMLLVDLDLNGAIEFVKSKISQLLRNEIDISLLVVTKSLGKVDYDARLPHVELAKKLRNRDPGKAPSVGDRVSYLIVKGTKGQPQFDRAEEPLYVVENNIPVDTQHYLDAIKSTLMRIFEVIMPNPESLFSGEHTRYITMSSSCDSALSMFMKKVERCLGCKSVIKVPPFCDHCSKSKRQQVMLQKFEERRQKEADYFELWSQCQRCQGSLHNEVICDNRDCPIFYKRVRTGKVLTALENTFQSLHLEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9T2</accession>
    <name>A0A061D9T2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U3 small nucleolar RNA-associated protein 20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0208280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767860.1">
        <property type="nucleotide sequence ID" value="XM_012912406.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D9T2"/>
    <dbReference type="GeneID" id="24564215"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208280"/>
    <dbReference type="OMA" id="EWRLKTN"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="2">
        <location>
            <begin position="1653"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2608"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2620"/>
            <end position="2629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2629" mass="295126" checksum="04112708E88E13DB" modified="2014-09-03" version="1">MTNRGKFKFESASKRSRSLVATDFSDIRTVVRNDGPLEKRRFFLHHLRNTLRSKDLLTHKQTLKDILNKSGVWSDGPPSSTLPFPEWSAYVVESLLRCAQSANSIELTTLCRLLAIFFKDYGDQDCLKVPFVGLLEVLEANKDSNAEAIFSFISTHFRSNSRCVSQDLGDLLTDFQPWLGHSYQLIRRLSMESLSLLLRRVPDTKLRDVLCRLLCMYVSCLQVPSCFRDGSEHLFFGIIKNVNGTFTTKLHPLLKFVISSLISDTFEPLCDGDVVDARRSISSSMRRAILLMSRHCRGAKLSFDWLDNLYDEIVCKYNDAALSPSAASAYSIGAELCVELLTVFRDDRRIKIKDIALVRSGACFDSFLSDYVVPLLSFAKEMGTPGAVLFEELSQLLARVVRTPGESANVLHDRFGEIIDYVFYFMSKGGNINPLMVLFEWRLKCDNLEQIAHFLLLISQLFDCREVFHPILVNPAVIARIWECIEASMENIARLRQERAANTDPVLVSDWAARLEMAMSVIFGCVKGLRSILALRCRMTSLPLEVNCNLLESILRECTVSLKAGESPDLVSDVFLQCCLLLEEPKCTVWVELLVGVANENPVLLSNPRILDEFCNRFTASMEATVVGVLALFPNERVDFRQSALRLFALYMSSKNANTVALDTLLEMERLESSMENERRKSLLMAKSVDELELRDEWSSENEMLVEMVFKVLLSQYYVKFAPNWEASSESHDKLLVRLKSAFSAKRRSTLDGLLKKLWTTCFEVVNACECEATEAKTTLPEFVVPFVVKGPFESTDPVTRQREVLSVMTSIISHTSNKESYIRSLCSYTVSHMLDDSKEIYRKNSLATVSSLLQKYKVKDGAAELVGLCLRDGIRSSDNAVREYCLSIVATSYPGLNTKRLQEVSCGNVGKSLDFEHSSPASYVADSNMQTLAVGIEIRLICPRIPQTSKQMHGNYTFDYLSRFDARYLNLLIAELLPGPLKSLFLTESDMAEPFYAWMVDLMCFNAELRNQLPLQKAIRTLSVLFMRLKKNLTAQSVNVFECCARILASCAGVRPADGIPEPLDIVGSKVDALIGITIELMIDLIDTFDELIPRFVSILSQHRGFIDVLLGRHKEVLSLVVCLTNHVEHLALICSSLIGPVLFRIFRLPPTSQLLELMDNLYCKYAPSLVSSSSPGDTVLDLLIAEAGAVLVCIKDYKPMGTHIMKAILLLPVNDDQRRACLSILLSNLPNVRKYTAHKTAKEASMNDQIQDLRRLLDCLKLCVSLLSGDDEPTINAIWDFANDCLFHINDLYCRRLCCEVLSSLPVEDISLESVCAHLHSMNYSNNNSIDAKIDFDSNCDHLTSLAMEFEEQTPSPKVVLSALSHALFVLLIGHKEPGLRRSVLTFTSCVIGIIHRSMRNGNAADPVDELPNQANCDYIDTSSLPYSALLLKAIFPFVRRCLGGAHLRESLFYVSIEVLEQFGGRFCEDVGARGLLTDSLHSDLCNVEVVECLSKLRNVHKYTRNEGLKQLSDLLSRDVVFSPDTTYRFLVPMCIQFLTQSQSPGYGLFCENARKCLISCGGKLSGSTLLKFLRQLIEVYDRHQVTPTLHVFSGVLQALPVTGDGSESGFLCGQDSDNDDSQWMVHKFRGMLARSQPDGDDIPCVEAYEALGSLLCHHSKRDRDREVIKYCRIICKSLCSRGRDPRRYGRQALKKFLHCMGFCYFPTVLKELSSNLTRGFQLYVLIFTTHSLLSSFAISDSSLKIRSGDDLDLIFRMITTEMLVKHEKQDTASKIDEERQSKSSSLLELLSEFGDIGVCLDICRYLWSLLKGSCNMPPDSSFEYSNTFLRNVDNLMSCCVRGFTANKHVDLYCLASVLFYGFLPSVKGVPALIKKELPSHISSEYTRVICNVGNYFKSFSDTEAPPVTSSKQPESTAISNTKKEEYYTLYPGASTGRSLAKAKKMGFDDHILSPLFVNAALRLYGRVLSTPENVFFSSENTKGDCQLEPIVSPDCVTSASNIAGTTTAFVILICFLCDDVTLQRSSVSCLFHLCSDSGRFMDMCGSVLADSLVKRLGTLHFVGSEDMVKDYLRLVGNFLQSRSHNILFNAWKKSGRSNELVAGLLLQIEANLDRPGLQSALLKLFNRLVVMEVSISRAQKTLYEVFQEVFIRMLKGALTPSAMRLSSRAVAQFLTIVPMEESNRSKRFGLLLKHVTSSISLVRLTVLQCLHQLLKNLTKKGSWKRYSELVGVGVAMQLLSESDLQCKRVMANIISLIWRESPVDQKRGLLECLAYFLGNSSGCKDAAYAYFLFHCLSNETSISWIRKSRVLDLSSGFLGLLEDLSCVKPSGPEWQAPYYWLRILCHILSSCQNFDFLFAVKCNPPADDPTSIVMNKVWVYTIKFGVRSSHPWIRAASLRVLTLVLNNRAAYDSIQGDPECNIYGIARPCLKLLSIETGMVERHEKVATALESCLQGIVHQTLSRASKTDSSIARVVSKVCYNLRLCLGKSRHCCRRIDILMSLLREYTSSTRAFESFLRATLLRVMIALTRATKCDVYISRSEGEESVSDEGTAVKRRSMASGIAREILSTIESHFRSVNDSGEYLKLLSFAQDFVSRRRILRMSKTSSSHAGGGRRVSKKRKRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA12</accession>
    <name>A0A061DA12_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical portein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769742.1">
        <property type="nucleotide sequence ID" value="XM_012914288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA12"/>
    <dbReference type="STRING" id="5866.A0A061DA12"/>
    <dbReference type="GeneID" id="24566097"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400480"/>
    <dbReference type="OMA" id="CTFVDMS"/>
    <dbReference type="OrthoDB" id="3548at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43542">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43542:SF1">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03602">
        <property type="entry name" value="Cons_hypoth95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="203" mass="22862" checksum="CCFB59169FAAAD21" modified="2014-09-03" version="1">MNRVKDALFASLQHMGVFAYGHECRVIDLFCGSGSVGLEALSYGATHCTFVDVSIQCCKATSLNALHCKFEDKESITSPWLHSITDTFDLLFACPPYEEIVYMDLMKQIANTTLLKPNSVVVVEYPREIAYLPWNIEDGKLLGYRNRKYGRTVVAIYCYKPKGTLLEACKNAQKEFVPTTYVRKRLKIEGFIAKESPDAPAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA29</accession>
    <name>A0A061DA29_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase rpc34 subunit containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0109030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766791.1">
        <property type="nucleotide sequence ID" value="XM_012911337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA29"/>
    <dbReference type="STRING" id="5866.A0A061DA29"/>
    <dbReference type="GeneID" id="24563146"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109030"/>
    <dbReference type="OMA" id="FSCDIFN"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="293" mass="33521" checksum="3458F7C5C5F0AEB8" modified="2014-09-03" version="1">MALSREEAELVYKLCVENDGIFTEEIFGRHIAKFRHSIQHGLVSNSVDFLNFLKLLKGSRQYSFHHDDDGKKYVRLRDKESREQVARLQDVEYAVFCTIETAGNRGIWTADIKKLCEITGNQLTRTLKVLVEQHGLVKQVTNVHQKSRKLYMLFNIKPARELTGGSFYLNGEFNEMLVEHIQEQVGSFLAKFQGSSLTQITNFLKTLENISGEVREEDVLSIIQILMLEDKVYSAPTALGDTIYIWSGSATPSFAQKAFGTPCFRCEQVEACQIDKYHDLCPSKCTYLKQWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA33</accession>
    <name>A0A061DA33_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome A-type and B-type family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0307010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768983.1">
        <property type="nucleotide sequence ID" value="XM_012913529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA33"/>
    <dbReference type="STRING" id="5866.A0A061DA33"/>
    <dbReference type="GeneID" id="24565338"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307010"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="21167" checksum="36FD94602B473108" modified="2014-09-03" version="1">MVGNGCVAIACDKRLGLNGQHTISSNFPKAFKITDSTYFAACGLATDVQTLKGEIEFKANMYELNCMKKMEVKTLAHMVGSLLYSRRFGPWFVSSIIAGLDKHNAPKLYCFDLIGAPCNADDFVVVGTCSEQLYGICESLYRPNMDPPELFETISQCLMAAIDRDCLSGWGAEVHLITPEKITVSTLKTRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA78</accession>
    <name>A0A061DA78_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0307710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769053.1">
        <property type="nucleotide sequence ID" value="XM_012913599.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DA78"/>
    <dbReference type="GeneID" id="24565408"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307710"/>
    <dbReference type="OMA" id="HINTDCE"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="874"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="963"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="484"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="829"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1262"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1559" mass="175184" checksum="6F0B973122F87800" modified="2014-09-03" version="1">MLPPTGRSGTGLPTFDNAGFFSKVFMYWVCSWVDFVGEEKCKLESVHELPQNDQLCWWQTVFARHVSDGLMRLEKSEMAASSPFEPKFKPYHSIFLRAMVLTFWRRALLTLLGIVCVDLIGIGTAILLKHLLDMLSKDSQHLSTVFGIVFGVVLVETTHSILQQHVELFIHRIEICIEAVITITLFQHGLCYRRHYSSVVDSTSQLGTCRKVVHFTDPTESCAPNPLLCPARRHQNRELPPSIYTHMVLDAATITNYVASVMAIVGFACNFLVGMVFVRTNMGFPILLPSLTVLGSVFFMLVLELVNGRLRRYSLESMDCRASVSSDVLGNLQICTAMGIDDVGYRAIEGTREDELTVLRHRLFFQFLNRALERSVGIILFWVFVYVFNNEVSKYENSNDIPFDVNELISVMFIVTKIVLKCGRLPKAFRWMVESATSYRRVEAFLRNCSPNFYLDANHVESASEPKELDKHSIPSHVPIDTLVYFKDASFSYINDRKLLLDSDQSSILPILKSLNMQLKRGDVKIITGNQGCGKTSFIKSILGDMSLVSGSMSVAPLSVGMPIFYTSQEVWLPSGSIRSIITFGYAFDEDIYRQVTCAVELESDFASWEDGDMRVISEKGYSLSGGQRVRLSLARALYAYLIFSKANERLVGDRCCFLVCLDEPFNGLDSSVARSILRNLLNKRNGLLVRPDVAVVMSMSTMTLDIAMTPESISGLVDVFVRVIENGVLKDPMSLGMHLGFDLTSDTPSSAKSGADDVSYNAFGRISNGDSARSVVMYKGITSGMSTFDQYPPLRTLSMVTSANGGKPANIWSAYLVYFRAVGYFLLFVLFLFILVSHASVNIKLLLAAKWVDTLRKATDGSDVDVMSHHRKYYVWITIFTFASVGCFSVLMFVVVFASLRGSRRLFGFALKSTFLKPSAILQLKSCMGALMTFLTSDIHIIDEHIGFYIHETSYSLLSFLVKFATLCYVMPVAVPVPLVTCFLLYYFAHRKVIRASKILQRLMLDANSSVNVVYNDVMSGSSVYRSFRKESMWLQDVRARSDEYYRTHFMKAAFTMWVTLATNMGATMMIAVFITIPVLRSYVAGEPHKVGQLGVAISLCLGFGNSLRSLINNYAQLERYMCSVARFESFFMQDGSSLYDKFDSMGENMLYVPPSYGREDSFVGTQTTSMDIDDVGDAMMPISSDHCSVNIPHSPEEVFEVCQQGDDFEASYAALLHRRIFEYRSHCFRRYISLFGWKFYKPYIEVLRVSDYLPPATLLLELKDVSLMTPTPPGTVSTHYILRDVSFCARVGDVIGIMGRTGAGKSTLLSVLQNVAPGRGGTVLLDGVELNTIPRKVLRHVIGVLPQLPFIFKGWTLRRFLDPRMLYSDDEIMHALDCCGMLELVKSLPGGCELDTVLVPEESTAVKKLFVAPPLCPLSGNGWASRSSEAPTLSYLKGNHSRIVLSVSQQRQLWFARLVLYRRMYRIILIDEPQWAEVADDDDEVRSCCASELSCFGSGKSICSLVYRYFSHCITFLVTHDRRMLRRCSRLLHVKEGMVRDEPSLMQLWGVNPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA5</accession>
    <name>A0A061DAA5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0109680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766856.1">
        <property type="nucleotide sequence ID" value="XM_012911402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA5"/>
    <dbReference type="STRING" id="5866.A0A061DAA5"/>
    <dbReference type="GeneID" id="24563211"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109680"/>
    <dbReference type="OMA" id="PIEHSIC"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="403"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="745" mass="81600" checksum="F8790D74509BFB22" modified="2014-09-03" version="1">MREWVDFSHLQFDPQLVKHLKLFGLEALKPFQYIMAKNIIEALGSMDAGAGKTVASKYVFHNDPDSGKSMGYILPLLHVYGTKEVSIGENVVTSQGSTLVVARDEKVSLSLGAMITAMNPNVECVILDDVEHYGADETRSKVPKATATGRTKDADQTIRGAIASNKSAGDLHKLLHDHKSNGSNGNCKVFVVSVNRLRTLLTSKSAALPTAQLAGVACVIFDDLSRYFAHGQIISDVYRRIKSAKISVAAAAEADATAGNVQPSNARGKRGKRQQRSSGVINGTSLATRAQADDVHIVCVVDSLGESFCKFATEHLSGFWLYDFKNGTRQKLVGDGRTDAVRLEVDLDATPEILAAAEGELPGGTNLPIEHSICKVAGGKSKSERIYALKCLVYHYLNLPTFPIQRILPPMLKRPKAAHQCIIFVANRSQQRHICALECFRDLAARLGSDLTVQERAYNLNSFRNGSRPILIATDASVAGCNFDDVRYVFNYQPPQTAEVYRSRAAIAGKNSNSLCVTLYSREQYSAFCNVLKTLGKRVSIHIPPSRDYMIRFNAAWLHKFANQLVELNPSFLEPFRSKAEELIKQHGKEAIFSKTLSLLLGSDCGRQDDGNMGTSELPRDCSLLTGRRGFVAVTVFDGGSDCSMSASDLVKLVQRLLPQLNTATLLGKYAKTESGYVIDVAAEHVSALLAAAANEPDVCFETPSQLPKMLLDTGTGSTKAKGHMNKLPWRRYKIRRLQLQKRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB8</accession>
    <name>A0A061DAB8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769679.1">
        <property type="nucleotide sequence ID" value="XM_012914225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566034"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313950"/>
    <dbReference type="OrthoDB" id="366456at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1753"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1815" mass="203325" checksum="08A1A291CBDA05EE" modified="2014-09-03" version="1">MTFLNHPNNLCLVTLHFPPSTSCHCPDHVPPRELGKKFCKILNLKNTSNNNPTNILNNFCSGLEKFLGFDSTSKGYDGSGIVYSDLDRLCDGVMGFLSGVLSNIKEHLGQHKNTLNEAITSLNTNKHGGKIGFNIAIGQVVEGVRGYNDAVSVSNNLVKQEVKKLNDKVSNAFLKDVDNVLADVRDKRGNLIPYQDKQVKQAVGQIDAKLEECKQNAQTFINNLDTERSVLKTSINDLNSDLKHKLENVRRTVEYESERLGRVKEQESKELKKTIEKIGEVMSTLKVDVDCKIGEDVKKFVDELRKRVTPIKKNLEKIATDLSQYVLELEQWIEKTQSFIHGVREKSLDAIVNEANDSLTSKKYPIEQDAKELLKWKDTLHFHIDNIKSTLQDKVREVKSAIGVIGRKFNDGISEVPDSIEKIMQHIKGKIEIIEGHVGDKKDAGLPADHRDASIYHNWCVLKEEIRDHVDLIEGRSGRSKVRNDNGITQIRQGVIKYAALFKESNGDDVGFGKVLKEWIPEIVSNEAVKGWIEKYIEDNTWNSYFNGELSARGRASVRPYVTKKIIEQIKDGINQIGPQKTFAHNNTVDDYLSYVKNYLNKFSAEVIKKGDDITNTIDGQVRYDRKLVQFGSTGRPNNTHLTLAVKATVGVLAVLAKRVAEQIASFTDGGEIKVGANLTHISKKVTEINNQVDDNVNNASPGVDYGGKIDVALQELHTKIKNLHGQLGMTLATSSTGGDTDTLASYVDRNITAIDTYADSIDIEHIKSNLVTLSNNINEHLATLSDAVSTSTNAVRRKLTELQNERIGNAAKSGTVAEDTLQEIHEKLHELQTGPVSTALKDATDLLDSYLAGADKHYTQLISDHVKKDIQKATDKLTTHARKTYVEAIKFLLTEFAGKVRTELRDLPRKIDADLKIGFKGFMKDFHVPLTNDLRNGDYTVHKLSYAFKLCFGPWQMLLEREIDRVDMEERKRKNRAPTVSEVTYTKKLKSVFGALDEVLMHFTSKNGYDHETHGKLDKLDAEIAGLKPETFAKPNTAILDSIAAGLTKFVSEMRSVYISKYDRALLTDDLTTNHRIKVTTEKSENTYDLTAYGKKCSKVCLTVFSILFNALVEMRRVCGQVGNVKRIYASTSDKKNPLGDFFRSNGYHVATDSSKQDGELRNHGECRSHNILELLVAPSAVFDKRSSQDHSGLLKDLFDYLHFYYQICHFTATSKKHPSSIFDMLCWLTGLSHNRVHHELTLNGFANLFEKPQETASEASDQNADPVVREDDDTDDSEITLKTEDDNALEAYPKKITATCLSDTLTAVCHQAEETLIVLLGHGHGDGIYACDFNTNPQGFQYPTNMDTLVCMLCEIVNRLYNQLYFLLDQCKRSTSMSGWRECEYGQGVGGSGWRCNDLSCGDCNSAEKCKRHPRCGVKSPLQSYLEDGLRGFLPHNLDGNSGKLNCPVKSHTNGPCKTPMGFKDISIMASHRYTGRHIRYVLAEFCGTASSPLTAMCSMLRCVLPSAPKTFDQMFAFFQCLLVDWNDQRFKSLITHREEAFNSAVIAANFENSSTQLEITPMLGTTSHKFGKHADGALYSLLSCNPSSNSSHACGPYMKPICSEVSTTFTVKHADRYLSSVLYLTESFYYVLQQLFEECNSKCGKPGTRCSTQSCAKGCERQQTKRSADPSHDHACISVVSCQSTLPILYKYGFTFRDAESLNGAKRINTKRTCVEFCKTLGNVVKPGSVLYNLVHKTIPEFLFKIRAPFIWLNVALWLLSFLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB9</accession>
    <name>A0A061DAB9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0209720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768005.1">
        <property type="nucleotide sequence ID" value="XM_012912551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAB9"/>
    <dbReference type="GeneID" id="24564360"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209720"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="11884" checksum="8B09DD532690C1AD" modified="2014-09-03" version="1">MWNEDSQPMSELSDCRSSCIVMAEKAITHCPTQQNKKCSIDSESFTVLMEDIDNGDLLHLASRLGRGVTEATIQYAPDSTTWYTGWCGANNSLRHTFALLFMVCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAF6</accession>
    <name>A0A061DAF6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769719.1">
        <property type="nucleotide sequence ID" value="XM_012914265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAF6"/>
    <dbReference type="GeneID" id="24566074"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400250"/>
    <dbReference type="OMA" id="YESKTHK"/>
    <dbReference type="OrthoDB" id="375908at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="275" mass="30947" checksum="F6AA7261421DE315" modified="2014-09-03" version="1">MPSVTVDIRDVKLSCNLPCRPNSLDRCTLVEPQQFVKQFAPEMITVKRLICDDIRRQCVNNTIEHLCEAPVTSIHSHMVDVWRSWRDPARVDTSTYQKSETYSGSTDLRKSALIPQDFGVWGLKYSPSDTTQRSYHLSGKSKSDKVSDRGFKSNPADYMASLQAVNEGRHMPDDVAIAVCGLYGKTATLAKRIVGAADLVAHIYSISGLIPETDVSRKFVVADLYNVEFLHARTGHEVVRPRLSNPFSLYSGAFNRTALENLREWPNLDVLKNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAL3</accession>
    <name>A0A061DAL3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769208.1">
        <property type="nucleotide sequence ID" value="XM_012913754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAL3"/>
    <dbReference type="GeneID" id="24565563"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309250"/>
    <dbReference type="OMA" id="WHICHIV"/>
    <dbReference type="OrthoDB" id="366222at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="200" mass="22747" checksum="46C8E659BF6E69C6" modified="2014-09-03" version="1">MAFKETLINMHRENVKGSFGGRLNVVHTLMVLHALEAAVTIQMFVSNYLYESQMHGSGFLIHCILNVVFNVITLIGFIPGTFWLYLSLPFHVIVCLHPSYVIGMIVGNLIFWMYVRSGLNDAKIFKNLFFLLVTRGLLAAVMTLFFKLYLSLTVLWYHLVLERIRAAGGNGREMKSALEIEMETRMGPNCRRGSCPIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM2</accession>
    <name>A0A061DAM2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="5">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0402255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769922.1">
        <property type="nucleotide sequence ID" value="XM_012914468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAM2"/>
    <dbReference type="STRING" id="5866.A0A061DAM2"/>
    <dbReference type="GeneID" id="24566277"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402255"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402255"/>
    <dbReference type="OMA" id="GRYRNED"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="278" mass="31370" checksum="FB9A6A54D49E957D" modified="2014-09-03" version="1">MAEGLRHVVHRRVHLERSQPQARRARVGRFLEKKRDYKQRAERYHVMERRIRDLAAKARFRNEDEFNFKMVHGKLGDDGVVVLPSSASVAARKLDKKGQFRRSLEELDRNRLVLRHRSAVKGKRAQAAVTDNATLLMDGGKHVTFEDGSDSDEGEDTDPDSATAGATRRCPSDSGESSDASDGSDSDAAPAAKTRRGKQSQAGSKAHASTAPRRSRATKRVREHLIALSETIEAKRADDQLRQRLDAERELRVAVHKKRQVRRARGSNVHVFPFERQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAR9</accession>
    <name>A0A061DAR9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769273.1">
        <property type="nucleotide sequence ID" value="XM_012913819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAR9"/>
    <dbReference type="GeneID" id="24565628"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309900"/>
    <dbReference type="OMA" id="FHPHEIG"/>
    <dbReference type="OrthoDB" id="440020at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2700">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="480" mass="53961" checksum="829867B9DD3DDE1C" modified="2014-09-03" version="1">MESWKSKIDAGGAVFRRLTGQFRAAIGEVGVQLKRHASQASREIGIDLDNLQQPFCKGLNQVQCSLFSAPGSCANKRTTVTISGEFDFGFNLKFHPHEIGVVIATVSGVNELDCSFKWKRRHASYEVDIEHTDGPRYALTADDIGTSLVIRCTHSGGMGTAIGEIGPFDVDVASRRAIQDALINSTARHDLFLERDASSVKCLCDVLKTPEHAVKTDGSSVKYAMYIMAEEVQLQPDDDIKGDGILKCKYSSSFPRLRLCTEDPLKLFLRISEKHELTLRAFSKQQRDMVALMLRAFHSRLLILNTLEANSLEVLRDGKLQDPTEGGKRLDVVLALQKANDDLSIMLEEAARTRRELSRCKHEKSFLESEIENTIKVFQQQLSSDDAAAAPRGKQKESYNETLYTELINRNAQLADQVSEITKERNAMEEEVDTLRGERNRLERHSQSVVKDLEKLRFDNQYLLKQIEELKAKIRKLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV4</accession>
    <name>A0A061DAV4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small GTP-binding and elongation factor Tu GTP binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0401790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769874.1">
        <property type="nucleotide sequence ID" value="XM_012914420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAV4"/>
    <dbReference type="STRING" id="5866.A0A061DAV4"/>
    <dbReference type="GeneID" id="24566229"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401790"/>
    <dbReference type="OMA" id="YVGMFDI"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="44"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="672" mass="72727" checksum="7883F52286928652" modified="2014-09-03" version="1">MTARNKRNVLVPFESAAVASRAFGFQAIRVSPEPPTPQRCVTPNALPVLAIVGHKDHGKTTLMERLTGERMVAKEPGDTTQQVVVREATIPTGGEPLHATLLDTPGDELFEVVRGRAIHIADAAVVVMSAEGGEAQTRDAILQADRFKVPVVFCINKADLEFSDAQVAIAELRAQCARMHKAGIIGSDLADCVDNAVAVSARTGACLPELGAEIARRLSKVTLPTNPVFLTDVFGGVKLGRVENFIRRTNCLVSSGAPPIAVCFVLELERTHSFGVVMTVAVRHGVLIEGCYFVAGTEYGRVSGIYPPHGRVAPDTKMERAAVGRTVRVTGLKTVEGTSADDLLLVLPQHEAFRLSQYRREVQLLRSQQVEGPPLEVPWAVLLQPKEDAGYGASSDSHCAPEKSEFGSTENRSGAATATHDDAFPSTSIYLHPVEDTVSDNGDIVVETDYEACDQTHSDYSESGQQATPTEDGGGGDDYNEVDELVEEEEAGCDPSGEADASPHEMWASKVEEQNKALLERWRSKLPPPPTKSKTPKAHGGIEPPAVTPEMGRPVIPVILRANFVGTFDALLDGFEALEKKHRVRIPVVHGGLGSVSPNDIVQADIGNKFGHCPVYAFQVPVLNDAIKHAVINHVTVKQFNVYSDLLADVERRCEGAVRRLEEKRSRELLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAW2</accession>
    <name>A0A061DAW2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767036.1">
        <property type="nucleotide sequence ID" value="XM_012911582.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563391"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200070"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1664"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1726" mass="194146" checksum="984345D29572411E" modified="2014-09-03" version="1">MKKLKPSVINSPSSPSPSAESDKLHSKLQALEKVEKLCENYEKLKTSDNNPKNLLDNLCDGLETFLGFNSASKGYDGTGIVYSDLDRLCDGVMGFLSGVLGAVKNENEVTTYDNYITSTNINSVVSKIHDCIGKGPEAFKEAMADVIFWLRKYNFVLQEKTSELTAEISKFMNSKIGYDYIKRVSGSSTKSLREQLSDWTNVVGEIQRDLTKIETENINALDKTLRNNIMHKFEPVKTSVQLLLESAQNDALVKQATKVDAELEKQEKEIKKEILRQSISITDTFKEGFQEVFRNIRHLSDVEKTQFGSIKNRLEEAQKFLNTKFDYEYKSHVIGKFEDIKTVVKNVHAMLSVQKQGLEKLVAYAWQHFEQLKINTIKKEPGNGEDNSIGKKWEELQTQIISIVGDINGTGAGHNKNHPSHDGLEGIQTRTKEWAEGFTHFENVVEKWVAEILNDGKGMVIDKVNKYYGNITENDKTAISRVFKEQLNAKVIKTNGPLTVRVMEGRDSIQQNINAVQSSCDKFAKVLHEKIKAHDTLVDIAKSILEAINLQVKTTTKTNDARDISDAIRSTLEQLVGMSRSASLEIKSVTAENSTYSLGKRVDEALKEIDNIRKEFVAGGEGRNGKFITAALITVNDKIRLLEPILKNEATGSLRATANAVETIVTELQEFTKTKNTNGSIEQKKQAVVDKMADLKSQIQSHISVILKAVVDADAYLEAVINDIQDALTEADIKANQAVNQLKEELTEKVDKAFHIINIEVKSLFAKERTAHLSALKTLVTRQLKIITCTVNKNLNTGLKGFLKTLSGDYVDIYLAGYKERPKHLPPKAQKTNPLDEVKTALERGEHGDKVATLSSTFKHYSEHIFDYLDKDLKHNFASQPQVIGQYDQTVSTIRSNLTDLLTHISAHKHFDHQVPEMLETLKTSLTSFKSSHFGNASYPVLDAFPRSLEQFVGELERMYVSRYDGHKQKVNMGKLVISDGDKGEKLTDDGRNLSKVFLTILVTLKAGLDELKQNAPNAWRGRQIYLQDSNEDENSFGQFLNKCGYKVSKSHDSHEGHLRNKEQCKGQYIHDGLLVGDKQHIYHSDKNGKRALEILFDYLETYNDLCHLSTLTSKRQPCSVYEMLAWLSGLTHNPVHQSKLSVAIMNVLEELYKRGREDEGEHGDVLAVERQADGGEFKVSLVDARSVSLEAYPRDVSYDELWAAVTHICSTSYDVLCAIAGHGDEFTTYAVDYSNNHMKFNYPQNGEDCLDMLLDILRRMLPTLQYLYSQCRLSNGLNGWQACKYGKDIMTAKWPCKVHPSDEPDNKSNCQAKCKPTCQAKCEVTCQVDCQPTSPLMSYLNDCLPGHLPHQLTKIGCKYECSNCSTSKKGKPCLTPLGFKGFSGSTRMGKDICEVLTKFINIKHLTGLFTLIPKPPSTLPEHFGFTLALAIGINATSRTNNYDPHAFRGVFAASIYEQTINLCTDQSTLTNALTDAYGSPSPTHGVCEHAHVRNLTASDSCKGKTNLELECAPYLANLSVDCYRYLGKKHSNLYLSWAVYLPWSFWTNLKNLYDAFCNIYCQDWGCRGCLRGDKCKRGEHGSISDASKQPNCQCHSIVDCRGVAPTLYSYGFSFGDPSKLQNEHYPNTCADFRKQLKNVLKSEYFTKLFEECDKFLFTIREPFIWLNVALWLLSFLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLGRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAX2</accession>
    <name>A0A061DAX2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L17, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0401950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769889.1">
        <property type="nucleotide sequence ID" value="XM_012914435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAX2"/>
    <dbReference type="STRING" id="5866.A0A061DAX2"/>
    <dbReference type="GeneID" id="24566244"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401950"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="22862" checksum="3846AAEF92A299D1" modified="2014-09-03" version="1">MGAIKMVKYSRDPSNISKCVKAKGSHLRAHFKNTYETAAAIRGMSVIAAKKYLQDVIDHKRCVPFRKFNGGVGRCAQAKQFKHTQGRWPEKSCRILIDLLVNLMSNAEVKGLETDQLYIEHIQINRAPLGRRRSYRAHGRIIPFLSHPCHVEIIAVEKDETVPKHVDAAKKVIKLNKRQLARFRLKDARAAAMAALRASRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAY8</accession>
    <name>A0A061DAY8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769343.1">
        <property type="nucleotide sequence ID" value="XM_012913889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAY8"/>
    <dbReference type="GeneID" id="24565698"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310600"/>
    <dbReference type="OMA" id="GFKAPAM"/>
    <dbReference type="OrthoDB" id="365613at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="116" mass="12571" checksum="85117EACFA0E73EE" modified="2014-09-03" version="1">MSSYGFKAPAMSREVIAELERKYKQATPVREGVVKVPPKEVDVCGVSSPDQHAIHIATPPKQPDTDTDKPVDKSAILEKLTANTPNLSPGFRLIADAKVCLKGNNQSPDALHRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ9</accession>
    <name>A0A061DAZ9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0402130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769909.1">
        <property type="nucleotide sequence ID" value="XM_012914455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAZ9"/>
    <dbReference type="STRING" id="5866.A0A061DAZ9"/>
    <dbReference type="GeneID" id="24566264"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402130"/>
    <dbReference type="OMA" id="GYAQEYL"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="114"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="292" mass="33090" checksum="9A0F682F161B599D" modified="2014-09-03" version="1">MLPWRRLCLRREMDPSYLLTTGQSFSWASVGDDLWVGVIDDAVLELRKAGEEVEFRSVFGSCGEKRIRSYFDLDYDYTLNRENAPASVLRVVDRRPGVRILQQEPLETLISFICSANNNIKRITQLCFALREKYGTFLGEKSYADTHIRFHAFPNLRQLSSASPEELRGLGLGYRADYVFRTVTALRESGIDSLLRLRDLPTEEARAELVRYRGVGRKVADCVLLFGIGKREVVPVDVHIKRIAKAHFGIKESGASSYEAVQTAFSSICPENAGWLQAVLFIDSVLWGTRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB41</accession>
    <name>A0A061DB41_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0402460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769944.1">
        <property type="nucleotide sequence ID" value="XM_012914490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB41"/>
    <dbReference type="STRING" id="5866.A0A061DB41"/>
    <dbReference type="GeneID" id="24566299"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402460"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04335">
        <property type="entry name" value="PrdX_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000037">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.960.10:FF:000005">
        <property type="entry name" value="Putative prolyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="241"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="682" mass="77907" checksum="92CA93DDD751534F" modified="2014-09-03" version="1">MAETMKTEELYKLLQRLGLRYTEYKHQPMMAVKQSLEDPIFQGKYDIIVKNLWLRDEAKRFYLLTALHDTKIDFKFLSKQVKVKHLRMGPEEMMEGIVGMKRGHLNPFAIVNDKNNEVKVLLDERIKGKAEIMAHALHNATSICISPDDLVRFLQEHGHEPTFVVTAGEEEAAPVAEAPAPATTDKEGHILGVTVKKSANFSEWYTQAIVRGGMVEYYDISGCYIYLPSSYFMWEVFQEWFNQAIKKEGVENCYFPMFVSKAKLETEKSHVEGFSAEVAWVTKYGDSDLADPVAIRPTSETIMYAEYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRSREFLWQEGHTAHKSEEEAMNMVMTSLNLYKKYYEEYLAVPVIPGEKSVEERFAGGKTTMTVEAYIPGSGRGIQAATSHLLGTNFAKMFGIIFEDENGTKQFAHQTSWGFTTRSLGISIMIHGDDQGLVIPPKVSKVQVVIVPIISKKEMQKQIMDVANEVFARLKQAGVRTHLDDRVGYTPGFKFNHWELRGVPIRIEIGARDVESKSCRVCCRFNGRKTDMKLDEIEINIPQTLETIQREMFEKAKKEMDQAIARVMDFEGVMPALNDLKLVLAPWCEDPATEGEIKAETQRLSQENSDGRTGGMKCLCLPLDQPEMPEGTKCFWTGKPATRWALFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB66</accession>
    <name>A0A061DB66_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">-Probable exosome complex exonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0404140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770112.1">
        <property type="nucleotide sequence ID" value="XM_012914658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB66"/>
    <dbReference type="STRING" id="5866.A0A061DB66"/>
    <dbReference type="GeneID" id="24566467"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404140"/>
    <dbReference type="OMA" id="WITIEED"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="789"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112260" checksum="152984460A8046E4" modified="2014-09-03" version="1">MKARVALSASPGVRSADVESRALSVTSPPEAPLSESFTVQKVLLILGGHDGSPLFTQVSPHLDSRERVGQIPELLRVSVGLQIAHLSPGAVRNSLDVFSHYGSCTLLLSRLLNALSESGYDSNEVSSGAPLAPSLACLLKSPSRHGTKSRSLFNWSWPVWVPGLCDGLHTIWNEWCWILSSLHRRFVSSLYREFCGVEALPDPNHSAALSVCHLMPADSKSPFLTSYLERCRVCPNFGSDVEGHESGAGGVSEFKVTLLNLYYHLRPFLSMLEDVVGFLESILNYMDTHALNIGSLYRVSFMFLLLHLRRSEDRQDDALASLWRFLLRHTLSQCNIPHSLGATASVVPGDISWACLGAPLHALRRVRDSLEQLGQHKLLSESSNISDDLYRQSDAFEPTDDTADRILNKLNDCITQLVSGSIVALRSVLEDRHNLTAHLSFLSGFCCLRFGDCLDSVFEFVCRPRVPLNYQSRLKSVLVEGTVQWQQVVDVKGVPVLSTDQVVSLVNRFEYLLKEDAWAPIIELKVLGGSPCALSSFLSDRVMAHYSSILRHLLSFQLLFGEVKQLVQLTLRGSGSVCGFFVPRATTLLLHVCFALDHYYRWVVASAWSELLRRLSACATVSEMSAVHESYVEFLLECLLVTPECASEPPACRINPLFSESLFLIRRCASEFLRICTSELDDAGDELGLVYMVLQSEVGRLKCTLNVLSSHVLPDVPEFGESEHELLSLALRHRVNLNSAACRAQPAARVGFDRLLSHFIPVAPTDVTPRSRQGASAEELHPAAPRFDVGVSCSAAGSSYVTVGDTKVKCCVNAPRPCGRRVFDERGLLTIDVRFSRPELRRSCSFDVCSVLSDVFERHLLLRRYPHQLIEAWITIEEDAGGLFCACITGLCIAFADGGIQMPDIISAASAYAFRDPQGSLTVALDLSDEEASYYGQIDPGLTKLHLAYCPNMNTIACLLQSGEHADSAVLNKMLTMAQAACGVITAEMQASLQDYVEWVQERNHDAAPAVGHYSELTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB78</accession>
    <name>A0A061DB78_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767176.1">
        <property type="nucleotide sequence ID" value="XM_012911722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB78"/>
    <dbReference type="GeneID" id="24563531"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201470"/>
    <dbReference type="OrthoDB" id="365142at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600224" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="124" mass="14356" checksum="B67AF60AF58D404E" modified="2014-09-03" version="1">MKVERIFCLYLGWLLACRATPTLQDSTYDEAQRDGVLPIVDVEMVAPKRWQAYRNGLNSLKRELSFVIDRGKLSLSTLLTRHAELERERRRIFQLEDQRSLAAPRASLMQLLPRKTTNDALHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB79</accession>
    <name>A0A061DB79_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative chloroquine resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0311350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRT-like transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769418.1">
        <property type="nucleotide sequence ID" value="XM_012913964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB79"/>
    <dbReference type="STRING" id="5866.A0A061DB79"/>
    <dbReference type="GeneID" id="24565773"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311350"/>
    <dbReference type="OMA" id="VNIAYNI"/>
    <dbReference type="OrthoDB" id="416555at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013936">
        <property type="entry name" value="CRT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31326">
        <property type="entry name" value="PROTEIN CLT2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31326:SF1">
        <property type="entry name" value="PROTEIN CLT2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08627">
        <property type="entry name" value="CRT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="419" mass="46245" checksum="AAEED2F2F2DA2574" modified="2014-09-03" version="1">MTDSSAVADEFGARPSDDGYDDYPRGAFLTDDLYGTSDDRLPELHIASAPRALMLTLADLIRRHKLLIACLVYVLMDIFTTVYYKRLMDHTGNYAIVTMEVLVIFFLGLFWSLYWACSYLFPAYMAHPFNYRQLIPMSLFDIVSTLLSTMGSVETSGIVLVMLSQVSIPLTIITCKLILGRVYHWYQYLGSLLIVLFVIIKELTVPMTTGSNNLVANMLYMASCLPDSIASALRSGVYMSESFHLLKYQVSAISLQFVLGFPLFAFTLAARRTQPDLGVLSGSLHDVGSGLACLFLGRNTIVDQCSSSGDITCDNCEGAFRVLLTYLLCNLIIRVAYVVIMMNATVTLVFLLGTLKLPLCSIAFSMKSLSGDSATAFEIIDVVCFVGIMASLGMYAMGRKMLDAPPECPYAQPMLPDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB84</accession>
    <name>A0A061DB84_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0404390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770137.1">
        <property type="nucleotide sequence ID" value="XM_012914683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB84"/>
    <dbReference type="GeneID" id="24566492"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404390"/>
    <dbReference type="OMA" id="YECRIRI"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600770" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="830"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="960" mass="108967" checksum="9044CA2FF55C773A" modified="2014-09-03" version="1">MVKPRMVSLLYCAIWMQWIGCLDALFCDLSDPEEPLGSHALVMCHMDIDKIEDAIGVCPRQVDDTEYVWHPQPTTDGHPHIETYVNDNGSLRARDFSDLVISENQASFISVESNQLQTKLHFNFPSHELFILTERRLIFICGPRDLVLSDTMQRHIYRLENSDQVEVMLWTSSTPLVEELKELRKGLGLFFVNIGHSHLLLQGCGSRTSPLFSPDNVVTEDSFTGTRSCVADPMSSLPIGFVCEGRIQPENCMKSLLDKNGYTVTAPSPHKYWHFDDHRPWVVAQYFDQLALPPFTGECRCVDSETGQVKARIEIRQKTEYTCDITSMIFRNRIRPIPGPWCSVVLHPGSTLTIKVPIQKVYRQSFDGSATVSFSQMMSLYDFETEFLPKDLMTLRQLQSIYDFETYDEIPYNQALVGDALALDVSQMNRGLVKLTYHSDKPLALKKGSSSFLYHLKLKSKNMNILERIDAAINLTFAFTHDYEVVGCDRESPSLFNPGISISNCLLKYMGNRIGLTYECRIRITRWRRKAGIHCRPDEELLPNNCESMVYDLYSNRAIELPTALQTTKQNIRGFQVLSFYFRNNSPFSYACICVDKHGYEKSKLVMENVQQEMYAYLVRRKQVSDSLRPTLLLPFSEIGLLFGGMKSQRFIGLYDINSISIKLTAGKTWSLNCGIDRESITFDDVENVATREDITATWLPKQPDIFYYTVNQTPVGPELVKVAYKDSIIISPNGLAVQYRELDMTPAYQIMVLQSNTSAIIISKDPLHKYFVPMTFVCGKAPNPWDLSVITDNASTSNDSARPSSHLLRPSIGYTWLVIDVSLKTTDPYMQGCGVTYSSTELFKPDTPKLYDAEGREIGCKIDIQTAKEAAFYCPAPYVLDPPECFNQVYVEDEVKNLSEISQSMIASASNHFVILNFDRELVGPGETLRPSPPLECRCVTVKGIVLSTIQIENYYSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB8</accession>
    <name>A0A061DBB8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0311700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769453.1">
        <property type="nucleotide sequence ID" value="XM_012913999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB8"/>
    <dbReference type="GeneID" id="24565808"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311700"/>
    <dbReference type="OrthoDB" id="10506204at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600229" evidence="2">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="198" mass="22841" checksum="A77077EE9244BC15" modified="2014-09-03" version="1">MRSFGVLLAGLALVCAASGCEAYSLHSSSASLMEFPLFKKSATKTEDKAKDKSGGKKKRGLWSKLRGSVKRKREAQQPAEDSDDENPEEFKKKRKQSWIERRKHKRQKRTHKERKTDDSRVDESSSDEEEHGHQRHHKDVTDEIHEHIEEDQREPSHVEPEVKEALRTISSTVKRSLISSIADDIDHAWNKLLGRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBI7</accession>
    <name>A0A061DBI7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0404010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770099.1">
        <property type="nucleotide sequence ID" value="XM_012914645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBI7"/>
    <dbReference type="STRING" id="5866.A0A061DBI7"/>
    <dbReference type="GeneID" id="24566454"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404010"/>
    <dbReference type="OMA" id="NWIGIGE"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR97913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="21006" checksum="260B5228AAB2CA96" modified="2014-09-03" version="1">MASNTFKLVEEDFKCYYDLKPGIRFIDMMPVMGDARKLRETVKFMAAGIRERHPEGVDYIAAMELLGVPFGAPLAYELGCGLVVIRKPGKLPGPVYTTHSKKVYDETDLHLQKDAFPEGARVILVDDLIYNGGTLAAACRLLQMGGAKILECDVIVDLPFLNGRETIQKEFPGVNVYGVMEFSPPKNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ5</accession>
    <name>A0A061DBJ5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0312000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769483.1">
        <property type="nucleotide sequence ID" value="XM_012914029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBJ5"/>
    <dbReference type="STRING" id="5866.A0A061DBJ5"/>
    <dbReference type="GeneID" id="24565838"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312000"/>
    <dbReference type="OMA" id="NHRISWE"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="23528" checksum="D34C4484BB3D9F35" modified="2014-09-03" version="1">MERHATIPLKLPKSMIAEFSETIDVVDADRSCMVKGVLHLGKDHTIAEKIAVSLAMMSAVKLNNVELTIRQKIVVSNAELDRLRQSMSRRNLDKLAERLFEYQTFAHHTRYWLNLEHDLLEIPDSLWEEDHLRALFRATQAVFDMPPRLEKLNHRISWQLESLQSHSEFVRHKHSSRLEKIIILVITFELALGLTQALYKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM9</accession>
    <name>A0A061DBM9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0312500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769533.1">
        <property type="nucleotide sequence ID" value="XM_012914079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM9"/>
    <dbReference type="GeneID" id="24565888"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312500"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600238" description="6-Cys domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="10">
        <location>
            <begin position="816"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="952" mass="107572" checksum="E42B9DBA87978FBE" modified="2014-09-03" version="1">MAKLGVTVLSAFCAITLHSIIRIEANVCDFSNPDAFADGFFVQCSVDTSVYPDSTAICPRQYKGIEYTWHPRPREMPSDKIYGYVKQSGKLASRKIRNMVRSEFKYFAGRYEATPSGIAMKFKYPEVPILAMTESRFIFICGPKTLVVSDDIEREIYHLSDITDDTHPNSSRPLHRRVGRNLKDIGVLFLNRGRTSGWFYGCGMLDSPLFPRDNNVSLDLRTDVMSCVVDPMTTRTIGFTCDGIVEPPGCNGLLSWYTEPAIPRISTDVRVWMTGRIFNDLALPEYDEMCICKHSDTYEVKSIIHFRSQNVYTCDIAGLLDRHRRRPISGPWCSVVLHPGSTLTIKFPTFIIDKDSETSDLIMMGINSNDLGFGPRDLEILRQLKSIDDFNSYEEVPYNQALAGNALELDVSEVEGGEVKLKYRKGRPLALRNGANRFEFHWTMVNAKHGRIHRTVATVSLALAFTHRYDDLGFDVVKQKDVDLYSVFNPEKKKKYTSVRRKGNGIGDVYEYRVPIDVASEPAVIYCKSDRMLPKNCGYESYDLLNNRVVGMGMGSTRVRESHLPGFRKLHFDSVHQIRVSKACYCVDQRGYEKYRIAFESHYPRDFVFEIFSQGVPKSRIPYVLLPWKDAEASSDGVTLSEWLRVNDVVEASVTMQVGDTVSLDCRKRQSSPLQCSPPPSEAHSDSTATWMPRQPEQFHYLVSQTGRAFDVLKRKREDSLVITPGGLKIGLEHDPTISPCRKLILQADASAIVISKDPLNYETYPMAFFCGIAPEGSELSVNSDTPSLPNMKVVGPANLEMWHMVRVNFETTDPYMQGCGVTYESTELFKPETPTLYDDNGQEIGCRIDINAAEEAAFYCPPPYSLYPPGCFFEVDMDGEVEEVDSISDYFTATTSNHFVILKFRSGFVRPGETMLQTPPLECRCITNKGVILSTIQIVNYHTNLSKYRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBN7</accession>
    <name>A0A061DBN7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0312600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769543.1">
        <property type="nucleotide sequence ID" value="XM_012914089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBN7"/>
    <dbReference type="STRING" id="5866.A0A061DBN7"/>
    <dbReference type="GeneID" id="24565898"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312600"/>
    <dbReference type="OMA" id="MNDVMSM"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="34182" checksum="59A5DD68A7233E36" modified="2014-09-03" version="1">MTLGFKNLRNAVGIFRGTAAKAGHIRGICATRRYSTAYTPEFIRSVFSNVATRYDLMNDLMSVGIHRLWKDTFVTEAVTAVADLNNEIAKATFEGREYEGPTVLKILDLAGGTGDIAFRILDKAKDMRIKDAGGFILHSPKTRIQPEITIMDPSCEMTDVGQQRAASLGFTDITWTNAPAENMPVPDDTFDIITCAFGLRNFSDRMQGLKECYRVLKPGGRLMILEFSHCESSLLGALYEAYSDLVIPNLGKYIANDVNAYQYLVDSIRSFPTQEELAEALTKLNFTLVSYRNLSGGIVAMHSAFKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT8</accession>
    <name>A0A061DBT8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0405220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770224.1">
        <property type="nucleotide sequence ID" value="XM_012914770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT8"/>
    <dbReference type="STRING" id="5866.A0A061DBT8"/>
    <dbReference type="GeneID" id="24566579"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405220"/>
    <dbReference type="OMA" id="TCGNRDA"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="491" mass="53821" checksum="1248E83AAD27EF21" modified="2014-09-03" version="1">MASTLNNEGGSGRKCRFATVDPADMPAPHINPFFRLFIYIYYILSSGCIYWGWNGIQEILYKAGAFEELCNGSTEVTQKVLYNAQYIDCPARAGGINNLYTLAYSTHFICSFFSGWLLDRFGPRICFLVGHFFSAAAWLLIFCFPTNGRLLQVAFVLVGLFCEACYIPMLSVSKYFPNGSSTVIAIMGSCRSLSYFVPTLLAWIYHLGNVEKKMLFAIGIGYLLVANVLCFVSGLFVIPKVIPVAPSEKNARTETGSTPACEVVTDSAVAESEDKKSLSVMDRIKNGLKSPFLLEFVILGFSVCFFMPSIEFINKSQGNLLVASGHGGDATGIFKYINIATFVPAPFLGAVMDKVGPAIVMNFLHSCTVLYYACAAFDIYAMKIAACCCYLLAGSLCVSTVYCYVNTRFPSQYFGTLVTIIFGVAGLVSLINIPLYNWGLTLKAEIPEQSFRPLAYVFMGYMGLACTLSATLVYISVIHPKRMAAMSMAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC38</accession>
    <name>A0A061DC38_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0400740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769768.1">
        <property type="nucleotide sequence ID" value="XM_012914314.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DC38"/>
    <dbReference type="GeneID" id="24566123"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400740"/>
    <dbReference type="OMA" id="AFNRINI"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="906"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="907"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1440" mass="159667" checksum="1FC0F28946C5B230" modified="2014-09-03" version="1">MASFNQKLFLQCFDQLADVDSLRRNQAVDRLLTYLALPPSASESDNKHSKSDADARSASKSQALNPLSAQRNYRFRFTVNDHNLLQYTVDRLLRGLTADRKGSRQGFTVALLSVLSLHGDNIKWQTISEAALEYTSTKDLTTSEVKDVLCGRLVAFFIIQKSGFFCTQEALPELEKVILSIWEAYDDKTYFQDASCVLLFLICRDVFRATQDVELALRHISPRLSAVLDANFVDAVLKSNNCEGQDKGKEFSKAILAAVGKSIPGVLPCDLLGLYLRMYSYIESVDKDLLKGTVLNKAPLDEDNFPLVLRYVSCTPRNHPIIGSFFDTLMNVIMLNEHNEPRLLQLWNSINLTMLNSQGSNSPQRTFTALRLLALIILKVRHSPTLIHALLTSCDDIYKTISYYHKASKKDPVKDISSYVLKLLVSVLHGDVHLATLNKVGGAVNPIVNDFMVFTGMNCLFEDASTDVRNLWQQESSSALNSPNSAIKKSNNVKKVNASETKKEHRVSFTDVDVPKLPADAVVDCLHKIASAVDFSASSLTAFQSLFAALIRSSADVLATYGLLESTAVNINIGSNAKRFYWLLSMLQQCVWVSHKVTRIELLKLYITSNALCASMSGAASSGLQLSIARISLDDDEFRMAIVSENNVGGGVTSATLPDETNDDSANTLQLLSKHMLNSCLATLSKALQALPNSRIEHVKGPRPMVIEIVNTSKVIRNVYRLLELGELPLVEFKVSPKEKQSKRKADHKDEAGSETLLHVSKRLVEFSLKLEKDNEDHRLTVLSLYYSTLALLLIVLHHRSSHLGRLSHGAAQADDSKPLFSEDNMDVIIAFAKLCENAASSGSTSFDSIISGILTKTLIRTIICEDNSSVFGLLHTISKGIWYMSKNQVNEELRDVLLRNSILNTDEQEAYDTDDESDSDDSSESESVTDNEESNGMDVDFATEENEDSEEEYENHDHDDSEVDDDDDEEDDDDDEEGTDEDSEEEIDEFDVEQSLDQPPSKKVKRESKEDEADESDLELSTAEAIDELLKDESGNIETLRMERMKMRSSFIFSPDSLKPKIRNLEMLQSCISECALGPWYLNAVNHLFSSYQTAVRANAGGSVDKRSQVVVSEYISKLTKVLSHALQQFARPLANQTSGKSNQEGESDESKTKVKFDDPKGMLDSLLDLAIQSINSQRAEKTSKACRSLAVAVLVFAIQVESMVSDGAPVQTTMVILVALLSICMFKKSRLSTSFFLQLCNRHPSVFASFNMVNISLESKVDFVQSEVLSVCASAVSAIAASNKVKPKRLCRRKCGKILSQMEPEIDWLFHGAPFDKAKIISFVTDNLVADVLKSLPDLLSRMKEGADISTIDSEPQESGKRKLKARSVSPQLAASAGRLVTVVVRSDAIKPEHKTVMQNIKGSMESLLETLRAVNVKEKQLQPLSHALSQLCARLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC95</accession>
    <name>A0A061DC95_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0205730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767601.1">
        <property type="nucleotide sequence ID" value="XM_012912147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC95"/>
    <dbReference type="STRING" id="5866.A0A061DC95"/>
    <dbReference type="GeneID" id="24563956"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205730"/>
    <dbReference type="OMA" id="CEPGCQM"/>
    <dbReference type="OrthoDB" id="364920at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="512" mass="57391" checksum="E48F74E69C59DF45" modified="2014-09-03" version="1">MANESSSGRRGVSLGLNEKVFRANRSMVVPSSNLYEANGGDSMFVEREIVVESHVPLVQDNWETTWSTFDHIEAAIERSIHCSTQPYVSILDDALGEVAKLEKQRAAKELEKQMEAKALQEQQDKKLAQQKTECTNKNQSDATSNPHVGCSKSKSHVEAGPASSHAAVANASLQATKGGIHTTTAGSKSAIKTAGTTSKYEKERDAADVTQADYVPRNSYTKQIDDYEAEHEQIKIEYDVFVQNSDPAVKSIRLDVAKAVNRTVNTLASTQKQVDHSYTTLLNIRNQYANEPGVATFVIFRVIEAVLDCCEPGCQMYLNPKAAWPSAHLIRGVMAMKSECRAIYYALIKKRCPYVIPRLYLSSNTSRLEALHRYSKDNSSTYFKRQMALLRLHIAVLVVTKDREGLWAWFAGFINASSKPVFKLPLSGVLVTAMRTAGHFCLASYKEQFRKVLSLCGDMVKKGQFKVQNCEAAGMYHEQLSHFFEEYRKKGTLEKPDGFEMKRQEEDLRRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ0</accession>
    <name>A0A061DCQ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767891.1">
        <property type="nucleotide sequence ID" value="XM_012912437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCQ0"/>
    <dbReference type="GeneID" id="24564246"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208590"/>
    <dbReference type="OrthoDB" id="366723at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="346" mass="38684" checksum="93ABE33E45BC4713" modified="2014-09-03" version="1">MVPVLRFIHIQCKHSAKYCGWAKCSYGKDAKSLDWQCNKNDTQYTDCQGRSPLMSYLSGCLPGHLHHQLNSVGCNFVCSTCPTSQRGMPCLTPLGFRAFSCSKRKGKDICEVLEDICGDGGVLTKLSSSLTCLLGLPPRCFPDIFAFYYQLTRMWNEMPKTPNGLDDKCMQKPICLEIINTVGCNYDTAKTFLDSCRNLYDSPSHFMHEITAGYDLGYLVGCNKQSCGNVTRPLNSSAYSVFASTYAERYLSWLVYICPQLVSFLTQLKESFGDLYCYDSLCSPCLNRDGCTKGKHVTSPCGCKSIVHCRGVSSVLYRYGLTYADVADRSQIRCHDFCTALDNMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCV4</accession>
    <name>A0A061DCV4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769095.1">
        <property type="nucleotide sequence ID" value="XM_012913641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCV4"/>
    <dbReference type="GeneID" id="24565450"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308130"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="9731" checksum="798D84719BF5F6B6" modified="2014-09-03" version="1">MVKSCRSSTRGSAAHLYLGTKQIIGCIFETASKTMSFECKSCDVSQQGGVLIGVACSLLIFAICFNVGIVALETDVFSNMFRKSPSLPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD16</accession>
    <name>A0A061DD16_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769215.1">
        <property type="nucleotide sequence ID" value="XM_012913761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD16"/>
    <dbReference type="STRING" id="5866.A0A061DD16"/>
    <dbReference type="GeneID" id="24565570"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309320"/>
    <dbReference type="OMA" id="LWELTHQ"/>
    <dbReference type="OrthoDB" id="366397at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="670" mass="73937" checksum="BF0DE5C872BDE887" modified="2014-09-03" version="1">MKQEEKNSIGFAIFKTPFSSEEDKAVCNQMTPKFGYADNVDMFDARNEDQCNVVELKQVTRYSSKASEYANSTKLHVPSMLNLQALPRRDLDDAFSMDDAKTSASISDTASPFGTECDKMNWNKKKNGESLVVPTAFSTFKRSRCDHFPGYAPSSTLQFADEPFFTGYNGSFASDEVYDISETNFDFTTVTGYGMDDDYTDNYVSIIDMVCGVADESEERAIGMRRDVLVEAPKELEPAAGDPPLYKQMQVKLSVAKKGKSNKKSRGSKASKEPIAVDPVNVTKESSEASGEVAKGPAAEERIEWYPGFNRQLGAKGRSALLELVRRVYRQNPPYYKSILQARNPPSSISNLPFFNIPMLWELTHQFGVFQQAVAIHKSQMSAALRNDKSRGRSRVDRSHAALAAQEAKAQQLTQEVAKDDQAKLSSQSSETSWDSDTTGASQEFQSSMQVDVPNGSQNKLAKLNEEPQEQNITVPQNLMVKRDATMYEQMSSVEATGGRATPPAQVEHVKHSRYQGVRGDNAGQVEPVKQHFTTLSGRSIKPTKRYADYQGEYGNQAKRYSAYNENHNQTTNDTVSSCDSNCTSRDPSNVIAECDSPALSSSTVVSLSKSEDGSGELDVESAELPPLSLVWCVKQQISQKNMDARCDAMAERLSPVASARGTPSRCISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ2</accession>
    <name>A0A061DDJ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769660.1">
        <property type="nucleotide sequence ID" value="XM_012914206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDJ2"/>
    <dbReference type="GeneID" id="24566015"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313760"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="172" mass="19755" checksum="962204B63B9E9087" modified="2014-09-03" version="1">MVENKYKEFVDKAVRNFHEAIERRTISINKRGKIRFTDESAVNRYTELELQISCDKPLQQLLQTVKENATLEKDFVSRLTYFYNSLYLFRGTSRTLIESTRMSCCENACVRSNRGVKHIGANSKWKVTEAFNSTATKIQEHYATVKESGFESGNNCIEDKSGESNATMVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK0</accession>
    <name>A0A061DDK0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769680.1">
        <property type="nucleotide sequence ID" value="XM_012914226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDK0"/>
    <dbReference type="GeneID" id="24566035"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313960"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="280" mass="29985" checksum="B83E6282C7389058" modified="2014-09-03" version="1">MKGLERHWYVLMRGLEAAVAEGSGSGSGTCCSWLRGLVEAVVVLQLAEGTGSGSGSVAVGECVARLRGLGAAVVEGTGAAVVEGSGRERGRWEGTIVPVVLDVRRVNVDAATCLVYGVEVYVLYVAIPLIGAEVKVYAMIWDVKTVAPAYAERGYTFSSGSSSPTRVEQHTGQLHHTGPTSSSSSNPAPYIIVPVALIIVVICVMIYFRIRPFHRTLMITLMKNHMSSDVTTSPQAIAAVVVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDR9</accession>
    <name>A0A061DDR9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768696.1">
        <property type="nucleotide sequence ID" value="XM_012913242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDR9"/>
    <dbReference type="STRING" id="5866.A0A061DDR9"/>
    <dbReference type="GeneID" id="24565051"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304140"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="210" mass="23296" checksum="14B0EBB977DB4768" modified="2014-09-03" version="1">MLQWLAGLKNKQHHETLKQCIKKAFSGLHKDPSQLALSVNGSHIRPKDVFDILQLTTMFAGSVLTSIAPKWKANVSSRIVNPNSSTQSDEPDCCALLCHLRDYVYACCHQLAFLKSQCNRDKSLGGWQDCHYGSDITSSNSPLQAFLTDSWDSTFDTHLFDPCNICLKSRVRMGFKKVDLPKIWQPGSVISSILTPSCGGEDHDAIRGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU7</accession>
    <name>A0A061DDU7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769890.1">
        <property type="nucleotide sequence ID" value="XM_012914436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDU7"/>
    <dbReference type="GeneID" id="24566245"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401960"/>
    <dbReference type="OMA" id="RELCYFC"/>
    <dbReference type="OrthoDB" id="366404at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="592" mass="66208" checksum="1C5E9BB01A524FDA" modified="2014-09-03" version="1">MHRTLQRRALGFESLVGLVKSIAADSGQAIHDADGSSRVMKRLQAVLDGTVALALDHPFHTPVIARQLANVTSRINVKGKHRCVTCGGTCDDIHVEIIRCVDRALPYLAPKGITQLMALYLPCRNPHMQGTLRNIELRGAFIMFCAIIANAENKAEIASEVANRLRRSYNGCMPSSNGDEAFAKFLNLGDLDGCHNAGECLEMPQYEVTIRDVCEAVCAVSEESHNSDLLLYLTHLRLQQIDIDTIKPNEVKTVCRILHALSKRGYRVEYNSKLASSICEKHARSMNAKDISCIFQAVQFRDEAALVPLLRRIEAILSKKTRQNAVDVKSVSVLITTIASIAHPGNVECLHTLKRCAEAIIGDVKRDAAIIGRPETFTAVVMALEKLQAFRCNQGINRCFGTMIGYMLHNRQLWVAIKRTYDLNQLLAILAAIRTRAKGDDHTRHKPTPNVFVGEVSELVLISGLETAIKRLSDLYVAGLAMINSRAEGVDNTLIRNLCHFLAIYREHDLCEIRRLDEEFNRELLHTLRRRHDCMTPVDVIELVLYLMTVDPQGANLATMQAAAIKRAETDSNVDERQWARIRRLVSHCKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDV9</accession>
    <name>A0A061DDV9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RIBOSOMAL PROTEIN L7/L12, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0305230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768806.1">
        <property type="nucleotide sequence ID" value="XM_012913352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDV9"/>
    <dbReference type="STRING" id="5866.A0A061DDV9"/>
    <dbReference type="GeneID" id="24565161"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305230"/>
    <dbReference type="OrthoDB" id="366264at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="7">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="6">
        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="237" mass="25615" checksum="5F60CC3AC8FF62DB" modified="2014-09-03" version="1">MEGPGAGCAGPSPQSDADSSAPISQNGYKQRRRWYAYSMSVPSYLFLAVACVLLCSACPLQALRTRCWRRSPHCWTFVGAPHQPMPPWPAGRGPGELRASKVDDILAELKTLTLLETSELVKKIEEAFGVSASMAVSAAPAAAGAPAMATAPEDEEDDEDKPKKTSFEVVLLERPEEQSVRMALFRILRKVLPDQPLTEVKAVIDNAPTTLKVVNKEEDAKEAVKLIEGAGGKAEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE03</accession>
    <name>A0A061DE03_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768921.1">
        <property type="nucleotide sequence ID" value="XM_012913467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE03"/>
    <dbReference type="GeneID" id="24565276"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306390"/>
    <dbReference type="OrthoDB" id="10367518at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596073" evidence="2">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="148" mass="16570" checksum="37947994722C4FF4" modified="2014-09-03" version="1">MIQLQPIAPWVVAAALLTGSVRYAQAKHECNLKCRLKPDWVESHESEPEEPQLPHGSQEFGDFITTLYKDWFGNYNRIGENGRILTAADAPREYKISKVFTITDVGFGRFIRITNTVFLCLAVGFLVYIFIQAKNSQNAEGGSSTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE97</accession>
    <name>A0A061DE97_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770275.1">
        <property type="nucleotide sequence ID" value="XM_012914821.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DE97"/>
    <dbReference type="GeneID" id="24566630"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405730"/>
    <dbReference type="OMA" id="WIEDADA"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3001"/>
            <end position="3023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="506"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3075" mass="343211" checksum="5340E493646DABB1" modified="2014-09-03" version="1">MAPKALTDCPENLREAIDWLIQVKHCGGISTVSDALASLFDNVARDAEKSQPSLLDSDRPSARDVVSKLRAFQSTLPEDSENPHKNIIHNLCASAGSLLGYRYPGTYYGSGIVYGNASRLCHAILAFLYPVFSDVHDNQPYVAGRSVLRDDVIVELKSQLWRGHKGFCQAIPRVATGLQRYNAAVKASNERVKEPIETVLNYVKPDGELCKGIKDLQISETSPLAEYERTVSTAVSLVEGCKEVARVFSRSLTAATNAINDFNPKLKRKLENARRSFFSHVDWLSRWSKKGEKKRLDKMVQKIKSKLKRFAKAVKDKIKQEVHAVVEVLKDRVKEFRMKLEAITVSLEKYVKELGQWMGEAKEYINAVKKYVDQIMKQLDGEHRKAIDRAAADIDSELGKKVEELNKWIEDADAAVKAAKEKAEDVYGRLDKDSSTKFSVGLKKIEAAKGKIESVSSELKNVHSDLGDWKVVVQDVISKAAGKADEVSEQLDPAQQDENHSIGKNLNDIETSEKAINEANESLQEEVTKLSKSITEADRIREQAQQKAQEVYDSLTVHNELSEKIKEIQAANQKIKDVNTGLKSVDSKLGEWNKEASTVIEGVVKTATEVYDKLNHGDNQQVIGQGIKQIQDAKQNVDDVAKGLTSVNEDLQKWREAAETVLSTTVDKAAEVHKALDPAKGKSTLGEQIDAIDTAGQYIKSANDQLKSQVGNLSKWMQDAEDIRHKAEEKVREAYNKLQVNEKLSKNVKRIVDAKEKIDKVHNAVETQVKELGRWKDQTECVIGRAIKNAEYVNDTLRDRLDPKIGEIEQHNDAIKEAQAKLEQAVQHLGKWSDAAKNVIKKADEKCDEILRRVKTDPSSKDDTIYKQAELLKYQGIKLLKAADVAKQTVESKVKDALEAVKAMDTDLKKDLFEVKTNIAEGIKTVIEELKVDQLGDKVKEDLKQLRERIVNLKDKVDKPSGSGLVEEQLKALGKAKTPLTEKTSQIKTQTEEMDKKFKETIKDPLDKGLQAVEGEIEKLYGQINPGGSATAADKKQLHKIFEHMKKEVAVIKGRAGNGVNDQNSKGLEGIVTNAKVLAQQFHGGKKFENKVNGFVMEILRENKIVQGILKKYAQDKGLGENYTKLDSSGNSPFRKYIAESLQIHLRDEANAAGKKVEEKFGEADNSREKIQRYITTVKEGLTTFVNEIEKRLKVEQINNLEGSIDTLVGTIVSGIVNDIKSRGQPRQIQTNDDLLKLAVKRIFMKLIVIVRKVAAEVEFLGTKVFGKILDTIKPTVDELDKNLKAVTDTGRTPVHGTAQAVDRAIEGVKGMVRSTIEQKFESDVKTPVEQAVQGLEKAVTEYDKQVKEQVREAVKGAIEQAAEEISTDENVTLGDVRDKMENFNGAYSLIIGGLQGQLSSILDKQLTSRADKVDINKAAGFKKYTGHVSTGYTTDHSYGKMNSAINVIKGEGLNALENTIGTTAAQKIEADAFKKPFKAIEIQLSTITDVVTNEGFKFLGDKDESRKGVKVLLAELKDGFDNKPVGESAKGLDAITKAIGELRKNTFSPKSEQIGKAVTEMKSQVEDLKNKLKSDGKDDKDSVINALKDLKDAGLASGKWNGKDGRQVGGLQKIEDDLRKQNEELRNQTIEIGKAFDYTLRELKGMLAQVGLRLHNIIVPDDVMDNLKDIKLKIGRGKNIGLEHIHELIKKLQEGNFTHNPEEIGKAKDEITNKLKKLQDDLQGDKNNDVIETLRDLKDVGLGNGDWKKKNNTKGLEKIKNELKAQLDELSVQPDFIDLGIAQITKQLDELRTTFQSGNKNPNDDVINRLEDMRRNGLSDETKSWNGKDGLGKIRSNFQEQNVKLFEARDQIDKATDIVLSHTQSVLKSAEHKLRSDVANDDVLDHLEELKRKIGKDGVVEDSLQGIHNKIHELQEREFVVQSKGIVEAKKHIEEGLQEQRMTLQKNVTNPLNDLVNKGFGPSENWNYLNAKGFNHIQDNLNTQQDTLSQQPQDIQNGVELINDELQSIRDALQGTADGNPQDRGVIKNLEFMTKQIGTHDDAGLKKIKSDIESLKQNQVPVITKHLNIMSSAITNAAGQLGWNLDQLETPHIDVKLKGIQDGFKNLRLSDLDDAIKLCDDFLHKADEIERNTIAALLKHVDNEVDDAIKELTKEARTLYVDSVRDALELFARKVNEDLEQLPSDINHDLTIGFKGFMNAVEGDEGVNIKQLMCVESRELKHLSAALGSFLGEVNEYVRQETQRVHKELGDERHPSLPPTEDPYVPQLDSVHRDLNTVLNYICDTETFDDKLRTLLADLKTAIAGLVPSDFKHPSTPLLDTVASGLTKFAGEFGNCYISTYSGQRCREEHAHKYAKVLLSMVPMTYNALNKLATKCESEWKPLHISKFTADDRDNPLGNYLARCGYRVSSYESGQEGELNNMFTGGGIYELLATPIEDVDIDMLVDGEQVTYDINLVHIISLLYNTLCHYFQVCHLYVPPEPRYPCTVRDMLSWLSGLQYTQVADKLPDHCKALLNRRCHDGDTPNTEDPVMAKCIGELSSIIATTCSRSNALLTAIQGNGHGFDMAAYPYSVDFSNNRARLHYPADPDALLDMLREIVFRLCKVLYFLYSQCCRSTARVRGWRECVYGRQVQSHHWQCNTLGSGSATNDTTTTAATTTSSTAKHGCPPTSPLQSFLSDCCHGLLPHTLTAADGTIKCANCTVNQPGKQCLTPLGFWDLGIAASISGTGWDLANRLGDMCRDADSCLFVLCRTLFWLCPATPSSLADVFALYAQALRKWDPHDWVENRGGNYTDASDLISHLNTDSIDGFFPLSAQLHGSYENHKLTSAISSLAGHDHKSHDALSSLFKDSTCKPPSGCAPYLQPLGLHAHHTYPQKHAGLYITWIIYLAWEFWELLYQLLQALDNIDCTAAGCATCPCQPGIHGGKDACHCPSIVQCAGPLPTLYRYGFTYRNAYLLVTDNRAVRCGDLNTKLKQALHSGHFTELFRQIDKLIWHIRMPFFYCFIALWTLVALYILHNFLYRLDIFRIRSHLLTTKASHFIDVKALVIPNRKMLSLYDADYFDDDPIGNIAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEL0</accession>
    <name>A0A061DEL0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0313670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769651.1">
        <property type="nucleotide sequence ID" value="XM_012914197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEL0"/>
    <dbReference type="GeneID" id="24566006"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313670"/>
    <dbReference type="OMA" id="RIGPWKT"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="126" mass="15294" checksum="AC54D4D1ACD196F7" modified="2014-09-03" version="1">MIFTSLTRYHWHYKTWQRLTAGYLRTFAKNRLPNNELIGYVINDKHPKSIRVACDRYMYVVRYKKTFRMTKKVWAHDEHKEAKLGDIVRVQPLGYRIGPWKTYVLSRVLHVQDPYLRDEENKDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET7</accession>
    <name>A0A061DET7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0403380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770036.1">
        <property type="nucleotide sequence ID" value="XM_012914582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DET7"/>
    <dbReference type="GeneID" id="24566391"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403380"/>
    <dbReference type="OrthoDB" id="366215at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="583" mass="64370" checksum="F69D1380179B92EB" modified="2014-09-03" version="1">MAARSRSSLMCMQSDFEKSPSAACPEQDEWYRELERHRTCLKRRCKELKTAFRSREHPQHTNGNCAEHSPVHRKARSPVSTPVSAVHGDKALHGTLSDVGSGICEHLPSPRALLVTPSRNRGDPSNATPAPKHSGRRFDPRKDRGAVLNSSCNGTAHRHLRLQRSSSVGSARSFEGGLTSCPSYADSLSERIPINFLLACKKGIGAVTPSRNRSFTLVDCLDRAPRLGTDSRHAHCLHRRGGISKPYERSCVGDRYCVTNFDRQPESRRQKAQQFCGGIKGTDKGHEQRPHPFAHPDQPRKSGVASTRPTCCADRKAHGGHTNYPYRADRCNHQGKDCRHCHRCHHCYGDNFRMSRVSCTSPANNEVGASLEATEGFSSSAREASPARRSEPGSPSRAPRQVDLQFIGNLLTGYHVNVDLLKAPELGSAESTRYVLSICREVFMGAIGAQVVYVVTSMLFGNIAAAIIVSLLCVQSAFCHCDGRPAAYVINGVLSLVVASTVTVALCTEVSGLEPYRVDPVLNTISYVYVPLCFAFGVFSFYLAHSNYDLHKRERQAIVYAVNRLLGDRFRVNQRDLTIERCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8R3I0</accession>
    <name>A8R3I0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0210520</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Parasitol. Res." volume="102" first="35" last="40">
            <title>A shared antigen among Babesia species: ribosomal phosphoprotein P0 as a universal babesial vaccine candidate.</title>
            <authorList>
                <person name="Terkawi M.A."/>
                <person name="Jia H."/>
                <person name="Gabriel A."/>
                <person name="Goo Y.-K."/>
                <person name="Nishikawa Y."/>
                <person name="Yokoyama N."/>
                <person name="Igarashi I."/>
                <person name="Fujisaki K."/>
                <person name="Xuan X."/>
            </authorList>
            <dbReference type="PubMed" id="17823817"/>
            <dbReference type="DOI" id="10.1007/s00436-007-0718-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Argentina</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2007-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Terkawi A.M."/>
                <person name="Jia H."/>
                <person name="Fujisaki K."/>
                <person name="Nishikawa Y."/>
                <person name="Xuan X."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Argentina</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AB330073">
        <property type="protein sequence ID" value="BAF91357.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768085.1">
        <property type="nucleotide sequence ID" value="XM_012912631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8R3I0"/>
    <dbReference type="STRING" id="5866.A8R3I0"/>
    <dbReference type="GeneID" id="24564440"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210520"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAF91357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="313" mass="34145" checksum="18ED8A112F6BE7C8" modified="2008-01-15" version="1">MAGMSKQEKKKAYFERLTHLVKTYPQILIVSVDHVGSRQMANVRHSLRGKAEILMGKNTMIRMVLNTSFPDSEDMAKLLSCIKLNVGFVFCMTDPLEIRKIILENRVPAPARQGVIAPCDVFISAGSTGMDPSQTSFFQALGISTKIVKGQIEIQNDVHLIKENDRVTASSATLLQKLNMKPFSYGLKIEKFYDNGHLVEAKALDITEEDILEVVKAGVSNVNAMSLALGFPTAMSINHSLLGAFKNCVSLALETDICFKEMQGIKDRLDNPELFAAVAAAPVAAAAATQEAAAAPAAEEEEEEDDMGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYS5</accession>
    <name>A0A061CYS5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0101000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765957.1">
        <property type="nucleotide sequence ID" value="XM_012910503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYS5"/>
    <dbReference type="STRING" id="5866.A0A061CYS5"/>
    <dbReference type="GeneID" id="24562312"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101000"/>
    <dbReference type="OMA" id="EICGHQE"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595276" description="proline--tRNA ligase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="74"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR93771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="452" mass="50513" checksum="BD4F4B5602A42726" modified="2014-09-03" version="1">MGRLRIFAVLSLAWYACDWALPGALFAHGELFGVPEARGDGVSGDHGAPLRRLLRKGGVFAKVAPGIHALLPVGRKIVARLERVLRVEMARLHTHELELPILQPERLIRSREAEFGRDLYKLKDRQDRVLHLSPTCEELACLVACNALSPLSRTRLPLRVFQIRSKFRDELRPCDATMRCREFTMKDAYSFHADEQSSEAAYEEFREGYKRILQKLRIAHTIRREDRGDCFDEEFDAELPATGDSSKLEIAHIFKLGTALCEEAGLSYEVEGRRKKPVHLNSYGIGIQRLLYAAAAQHSDADGLKLPQIMAPYDVAVVPCDTDSAEVAQLAHDLHVSLSKAGLDTLLDNRDLPLKQRTADLRAIGVPHVVYVSESTQVGGTREPSGAVAEAIRQESRTSNEYHLGQSESALLARSWPNVDTSRLDKPVRYVHRAFEGDFVLPAARLLELLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZH6</accession>
    <name>A0A061CZH6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766217.1">
        <property type="nucleotide sequence ID" value="XM_012910763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZH6"/>
    <dbReference type="STRING" id="5866.A0A061CZH6"/>
    <dbReference type="GeneID" id="24562572"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103450"/>
    <dbReference type="OMA" id="YFEDKYH"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="563" mass="63863" checksum="7CF8296799CCDE3C" modified="2014-09-03" version="1">MEFTTRNRSSAGGQADPKQPRPKKTVKKQPFSFARFYRDYGLVLWLALIVFMGLVMKYFEDKYHSMQNFTEFGEDIYKVMGIPRSASDAEIKAVYRQLNHKWHPDKNPDCADCKEKFMKLKEAYKILSNPQLKKLYDSTNGRTVDVISSSTTELTRENYDELVRNSNDVWAIQVYSDDLYECHQFAKHWEEAANNLSHFANFGRISMLLNPKAAKKLRVKVQLLPAVIMVFPGGGFDLFPQEALRSFKHFKEYFVQVYPDKVVACKDQAEFKQKAEAVVGRPALIFRNDGNNRPAPLAIRHLALKYKWAFDTYWTSSTVPAHQDKVFIDDLMDASKGQSNLVPTTAIFQLREDLDALAIMYGADHVGLIATAPYSRGQIGPLVECIESMLVLAYPPLELSRDTFTHLCKNPESTRDRFCVVVVGDAHRAFDEKKVLERLAQFVHGARIGSVFSNEFSDPEASGAAVPTADVQLVRLPEAQSTPKLREFVASGVILLDAARNKFCTVESADKRFECGVQDDLAWVGDVAEGAFDTLAWHDTNQAFGGSFEDKCLKSKRLWDRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZU6</accession>
    <name>A0A061CZU6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766124.1">
        <property type="nucleotide sequence ID" value="XM_012910670.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061CZU6"/>
    <dbReference type="GeneID" id="24562479"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102660"/>
    <dbReference type="OMA" id="CLSHPMV"/>
    <dbReference type="OrthoDB" id="306953at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0711">Selenium</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="42866" checksum="DE9A3FA903DDFBBA" modified="2014-09-03" version="1">MAKALTDSEKAFLGNGSENYRTSAAAFKWEESEQWQHYYNNLFPAPPASKLPKYKRAWYRRAVDPNFPADSTVGDVDTPSTSKSTSTPTARPAQETPRRSFLTYEMVKDVLVRLELAARLIFLASTFLMIALRLTRILPVRHFMVSRWRVRSANVPQLTSTASTMSYFLFLIFAILKDHGKPRVSLEYLTRVIGDGNLIYIAFGAAVFHAPKALVILAPQVLTCLIGLDKLYKNHHHLMPLLLKSDIAVAVFKQVDNYIVEMHTLRAVMEVAVLFHMIFGLIFGGWTIISVLLFSNFIKMKUVAGRTQHHACRLARNDVYLVSVLRQVHGTRVYMRVSRCADAISRLVAHPSLPPVVRNGYHKVVVLLQKYFMPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0S3</accession>
    <name>A0A061D0S3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0107100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766587.1">
        <property type="nucleotide sequence ID" value="XM_012911133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0S3"/>
    <dbReference type="STRING" id="5866.A0A061D0S3"/>
    <dbReference type="GeneID" id="24562942"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107100"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="452"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="608" mass="67708" checksum="2E9B3AE3C67EEEF7" modified="2014-09-03" version="1">MGDPPPADSSSGEEEFGPLPIPEPPKAVRKRKVEINDSIYLQHLPDASRYERSFVHNTTVRHVVCSAPTRYIATGSDDGYISFWYYENDGVQFVKRIEAHKARITQMRGSREGLFLGSISLDRTYNHIDFASFDVVSKVSLNFVPLCFEFISNHTSPHTIVAIASAGDSRVSLFKPTMSSTAICSLAIATPDIHTLVYNARFDVCLAANRLGDVDVFDANTFKFPVKHSQLTFRMKGETDLYEFHKVKTHVVSIAISPNGELAAMHCHDGLIRLFRFRTLKLYRVYDESALMYSAVQSDPKSAVLHMDSAEFLKRRAYEVELFKVGVDCGEYSGLCFDSSSNYLIYPCMLGIKVVNVVNNKLVRIIGRLEHSVRFLKLDLMQHVSRKRHMGSAGSGANQTLDPLVIATGFQKNRLYVFSNREPSQEELEGRDVGTASDPRDTSAPARTGGRLAREAVIHTSMGDIHVRLFYKDCKRTVENFTVHALNGYYNGCTFHRVIPNFMIQGGDPGGDGTGGESIWGSEFEDEIVPHLKHDRPFTLSMANAGPNTNGSQFFITTVLCPWLDGKHTVFGRVIGGTDVVQAIERVPTNSDDKPLTDVTIINVKAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Z4</accession>
    <name>A0A061D0Z4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0107840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766672.1">
        <property type="nucleotide sequence ID" value="XM_012911218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Z4"/>
    <dbReference type="GeneID" id="24563027"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107840"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="488" mass="52895" checksum="EE45CA5750993579" modified="2014-09-03" version="1">MATSTAETPKKKGDYNALGKALYNVVSFFEGYDQQILSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCLIWGLLADTNESRYILGAGLLLMGMASICLSSASHYKVYMYLQIVFLRFLHGLGFACVYPVQQKIVAESDDPKDSNAVENRGNQTNKKPKSSSKFTIFQALNCIGRLLCAVITTIIARKVLLGYYGWRTSYVVLGYIWILFAIGIVFGMVLKENSTGASSTVTPSSSYSETSGTSFTNKVSGAFSDVFKCKTAGICIFTLFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSGAGGEIIKKIADEAGNYVELGSGIAVMVVRLVVCLLFFLGKAPCGKLLWYHYVELATLGGTLVTVGGVDRAIMKDVIDNKNQGTAAAIIRTISGISSSVILYQVSAYLTESLFGYVPSRESFETMATDIKERNAEALRKSMMYIILAGTVLNVVCYIAMCFTYKDDRKSKQTPNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D151</accession>
    <name>A0A061D151_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">snRNA-activating protein complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0101510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766008.1">
        <property type="nucleotide sequence ID" value="XM_012910554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D151"/>
    <dbReference type="STRING" id="5866.A0A061D151"/>
    <dbReference type="GeneID" id="24562363"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101510"/>
    <dbReference type="OMA" id="HHGDCEH"/>
    <dbReference type="OrthoDB" id="46583at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="508" mass="58324" checksum="5567C68788822D27" modified="2014-09-03" version="1">MAWSQSGPQFQRVPHFDICELFDLSSIIIVDGERRCTRPPYCHYESDHEAALELSSSLYPAPKHRRTGVGSVSVLAPRPLPPELQPTVILDCDLKKDLPTSHVDLFAFKDEYRQVIERLDALRQKSIDIKKSRLKRQMKGVTSACLTQLCQLRTETSLKRYLSQPIRTPTITEVIWDAANMNLRHMAKIRREQGQNARKRLDITVDEDSNVWSEKRLHKLFADIVTLDSYQLVIGERRYAYRNMPHELETTRPLILTGPQNQSSAPLLHQSATERYLEEQSRSALIMAADDELIVTVTLYHGVRGHKLREYDILASQSLADLRDAFRCPAEIRPVGVDLEVRGSCFMLNGQLFPDLRGDACDYSEPLLHFYQQFKPGALHTSECIEQSDAILYHMELPVYIPGYLLHHGDCEHRMMITAVRAFDRVRDCPYEPCYPVCVFMPRRRSVQCHICELREADKSVFNSLALPQIPCYLCDDCYGRFQRLGTLDGVYRSDGLAKTAAIEFCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D183</accession>
    <name>A0A061D183_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766579.1">
        <property type="nucleotide sequence ID" value="XM_012911125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D183"/>
    <dbReference type="GeneID" id="24562934"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107020"/>
    <dbReference type="OMA" id="RHEKYSF"/>
    <dbReference type="OrthoDB" id="341422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="441" mass="47062" checksum="6CC71699C787AE9B" modified="2014-09-03" version="1">MAEQKGADAKEQAKPETKKVETPEFLRKDSTLSTKSVSKMVATATQRHDRWCFESNAKSSQADANEQSSAPSSPTRESLKRIPTGCVKAAINCFESGPQTETGTAVEKKPVTESKAAVPAAKVVPPKQVQTVFENNPVAKSTATIRACDAVPFHEAPSVFENEPVATSKADARACDSLPLRQAEAVFENNPVAASAADARSSEGNVTKVTSGTFENVPQGKSMADVKHSDKVARCSSGMFENTPKERSSASVRHSDKPPAAESQVFENVPQLKSRATVKYSDPVARGSSGTYENTPEEKSSATVTSSDTLKKLSSSTGGIDEISGELKSSGSVKYEDSMTTTASAVFENEPELKSKASVRYSDVLDTAVQALSEKVSGTFENEPALRSSATIRYDEKLQNTHSGTFEAQKSEKSSADFTSGGSLMNELHATMAECRIDSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1I5</accession>
    <name>A0A061D1I5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="6">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0103040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="6"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766168.1">
        <property type="nucleotide sequence ID" value="XM_012910714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1I5"/>
    <dbReference type="STRING" id="5866.A0A061D1I5"/>
    <dbReference type="GeneID" id="24562523"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103040"/>
    <dbReference type="OMA" id="QFEQHVT"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000115">
        <property type="entry name" value="N-ethylmaleimide-sensitive fusion protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="263"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="543"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="757" mass="82947" checksum="FDB70ADEB9CBCCE9" modified="2014-09-03" version="1">MQRFTCTVGKLPEESLSYTHCAYVHQDLYNVLKSTSFMAYGSVNTMIFCFRQHPACGRNDIFLNSCARQLISASVGETVEVSPVDDNRRSGLFGKSGDPPFNRAGRIVFEVSFFKATKKGTCNTGAAVQHAINFDHLEIAVRESLLHHVLHLTQTVAILQEGVTLRLRVTNIAPEGGAADSESVNMLMRGCLGEDTKLDFQYIAPDGRHHAIPSKDSGILKPNFKFEEMGIGGLDNEFAAIFRRAFASRIYPPELLKQLGISHVKGMLLYGPPGTGKTLIARQLSKALNCHKPKIVNGPEVMSRFFGQSEENIRNLFKDAEEEYARAGERSSLHIIIFDEIDSICQRRGTDTSGTGARDSIVNQLLSKIDGIDALNNILLIGMTNRIDMIDEALLRPGRFEVHIEVGLPDKAGRCQILKIHTKTMRESNRLADDVDLDEICAMTNNYSGAELEGMVKCAVSYAIQRHVDGSDITKPKDMDKIIVTRADFLLALSEVRPAYGVDSSNLSGFTRHGIVPYGQKFHQVLETCKILAAQVQKSEKTPVLSVLLHGAVGSGKSALAAHVASVTNFPFVKVVSPENYIGLSELSRVNAIHKAFDDAHKTPQSLIILDDIERLIDYSPIGPRFSNTILQCLLILIKKAPKHGRRIFVIGTTSEDSFMEMANVTQAFTVAAEVPMVTGPAEIYQALSGASSGAVQFPEDEINKVANCGKISTIGIKSLLLALEIAIQRTAEEGGKLISSSTFFESLEASGYNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1J0</accession>
    <name>A0A061D1J0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766173.1">
        <property type="nucleotide sequence ID" value="XM_012910719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1J0"/>
    <dbReference type="GeneID" id="24562528"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103090"/>
    <dbReference type="OMA" id="LCKCLCE"/>
    <dbReference type="OrthoDB" id="366863at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="373" mass="41046" checksum="3173B9B97E73C61F" modified="2014-09-03" version="1">MAAEAQKNQCKGCKQESPLSGTEKFLLEGEKCCSENCERCKLKNCGDEKKCQCHICTCGCQDEKNKGKSCKNSSCVACRVICKQLKDDARCRCTFCDCGCENALKKGKLCSDKKFSSCDKCEKKCGKSKDGSCICYLCSCGCNGVNCQCCERCNPETKCEGKDTCDTEEQHDKTTCPKGMCKEKAGSCFQVTCMCKDLGIEKRDDVCECLCKCQKKCPRITCPKLSGGACPRPGTNGRCGCDCTCSCNACGKYYDGNGKLVDVCGNDAAMRFYAIGKCRFKCTNCGRLCDQDRCMNWIRVIVIGLIILASLFVLRAIFPEKFRAIMTKIRATFASSPVHSGRSLNNLVGHRIPEETNVDRYPAFRPRAYAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1N0</accession>
    <name>A0A061D1N0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin domain containing protein family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0109990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766887.1">
        <property type="nucleotide sequence ID" value="XM_012911433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1N0"/>
    <dbReference type="STRING" id="5866.A0A061D1N0"/>
    <dbReference type="GeneID" id="24563242"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109990"/>
    <dbReference type="OMA" id="KCAEHVD"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="335" mass="35301" checksum="08E20C2EFCBD2419" modified="2014-09-03" version="1">MAIKVTIKISGGETFVVEVDQSITVLELKEKCAENAGATADKQRLIFKGRIVKDDETLESLKVEDGNTIHLVRSGVKPATSSGAASGTQAEAPKPTPAAGVNANAAPTAGAFPFGQANPFSPDTMQQMMQGMGGFGGMGGMPGMGGMGGMGGMPGMDDFNPQTAAALLNNPMVQEMMQQISNNPQLLKEIFGNNPLLQPMMQQNPMLNQMMNNPELLRTMMRPGMLQAGLQLHQSMQQQQQAGGSTAAPAAASPGTENMLNPLMGGGFPGFNFPPAAMPTDTRPPEERYAFQLQTLQEMGFTNREENLSVLNSTGGDISAAITRLLEARGNPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Q7</accession>
    <name>A0A061D1Q7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0103810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766253.1">
        <property type="nucleotide sequence ID" value="XM_012910799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Q7"/>
    <dbReference type="STRING" id="5866.A0A061D1Q7"/>
    <dbReference type="GeneID" id="24562608"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103810"/>
    <dbReference type="OMA" id="MDNSHIS"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000009">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="267" mass="29860" checksum="03F310A508ED5DA1" modified="2014-09-03" version="1">MFECRLDGMFLRRLFEALREICNDISIDCSEEGLTMQAMDNSHISLIHLCLAPDFFQLYRCDTPCTLGINISFMLKILAVVREKSTIYLARGDDSDDPVLSVRIVDPAGAGAYEDVENEALEAQVKLIDVEREHLDIPNCEYTCQCVMNSKRFQEFAKYLHSIGDTVTISMNKEVIKMEAEGDGIKASKCFHNGVGEVRVTSSEPLSQMFATRYLVLFSKATSLAQEVSINLSAGIPLSVKFNFADPMAMNDGDSFINFYLAPNIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1R6</accession>
    <name>A0A061D1R6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0110290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766917.1">
        <property type="nucleotide sequence ID" value="XM_012911463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1R6"/>
    <dbReference type="STRING" id="5866.A0A061D1R6"/>
    <dbReference type="GeneID" id="24563272"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110290"/>
    <dbReference type="OMA" id="STIHAHK"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595360" evidence="3">
        <location>
            <begin position="26"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="622"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="858" mass="95393" checksum="8BFD72066288BF90" modified="2014-09-03" version="1">MGRGVTWAYLYFLLLVKSLRVHTYARIPANRAISESFIHCFGARGAEPRQRDLEPGFRTASGCGYRSFRSNASNKGGAKGSKKTVISGTAAERQALIDRSLELGISQDDIDDYLKQYKVVKSKRPAAAATASKPEVAPASPVTADKETAKPPGSPAEQPKKRKLPKRLLEKSEYLPERGVEYPLYDAIDRIKLISGVRFVEGIDVALHVPLSRKKIRATAAHYARLITIPHQSLKSKRCRIGVFAKPAVCDQVRALNATKVLFVGGADLIEQFKAQDQYPDVDFVLSDLETFHKLATIGRQLGRRGLMPSLTVGTCIQHTADLLDTVEKVEHRNTFILRADRVGDIKCNFADVTMPREEIRENLLEIVKYLRQNKPEFAGAQLLSAAYVSSSMGPSFRIFLKDLGCRGHMGDDSADSIPLAQRMGIDRISIDYAATLVPWMTRGRYEKRIRVPRHRDTPLEFNSVRPAFCYSSFSNHYNGVCSNLAHASFNRNKFPIVSLKWFPNGKTLLAGSQGGKLIMWNGLTFQFDDIKRYPVSGGSVTAIEWSPDGDFLISGDEYGKLALLSPALSLLDNTLFEGLGKPVLDVSMSHNGAKVGACADTYSPHIWDVQRRHLEGVLSGDHVDSTSVSCMQWHPSKSLIATGSKINVVSLWDPATRTQISTIHAHKAPICKISWNPDGYAFLTAAVDGLVKLWDLRMMKQLMVYKIASPPAPSANVNAAGQPMPPPMKMLTIPTTIGWNPVQRNVFAVCDNKSRLFFFSSDFSEPLAEINVNVTDDRDTATLAMDWHPMGHLLATCSDDRVVRFWSRSNPGGMNQQKENVKTFGDSEFVRSFPLSRYKFKRKLDISTLPCVTRDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1X1</accession>
    <name>A0A061D1X1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0002620</name>
        <name evidence="2" type="ORF">BBBOND_0109310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK055047">
        <property type="protein sequence ID" value="CDR71608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766819.1">
        <property type="nucleotide sequence ID" value="XM_012911365.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770555.1">
        <property type="nucleotide sequence ID" value="XM_012915101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1X1"/>
    <dbReference type="GeneID" id="24561831"/>
    <dbReference type="GeneID" id="24563174"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0002620"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0002620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109310"/>
    <dbReference type="OrthoDB" id="2193044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR71608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="144" mass="16885" checksum="4A5904A5B3096574" modified="2014-09-03" version="1">MILADRRRNSVTIVEIGITNRDYLLDTDKFKKQKYEDLIEDLKARQFNQQTKIRVIPYVMTWEGIATKEHRKYRRDLGISDRMEAHIQRVVIQETHKIVMRDMKPKEDYDSVEDPQAQTGWMPAWMAPVTSGNGPAWIPQPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D260</accession>
    <name>A0A061D260_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elongation factor P, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767017.1">
        <property type="nucleotide sequence ID" value="XM_012911563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D260"/>
    <dbReference type="GeneID" id="24563372"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111290"/>
    <dbReference type="OMA" id="KFACQAK"/>
    <dbReference type="OrthoDB" id="10259892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="ELONGATION FACTOR P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053:SF14">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR KOW-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor P/YeiP central" evidence="1">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="137" mass="15403" checksum="2715C0E3DA0C8FF4" modified="2014-09-03" version="1">MIFLHGGSALFHYIYYATDKYCEVVSNRQVKQGRGSASIQVEYIELSSKKQMTLNLPIGAKVEKIDVDRHGALVQYVDEDTREIVVSDQNFEDTRIPVSLVGDGAKLLEAGDELQVFYHDRTIVKVGLPNSVQSRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2C1</accession>
    <name>A0A061D2C1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0110510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766939.1">
        <property type="nucleotide sequence ID" value="XM_012911485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2C1"/>
    <dbReference type="STRING" id="5866.A0A061D2C1"/>
    <dbReference type="GeneID" id="24563294"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110510"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="95"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="426" mass="46390" checksum="F4C2875B64F48696" modified="2014-09-03" version="1">MDAYDSSAVVRRTPKDAESSIGCITTRSTAWSIDDVGGAYCDDGALGVDEASVFLPDECVENHVTQLVNEFGRMGYDYCGEAMPTLSNPSHCTFHRVRSAMGHPCFAKVVDLHTGSAWQSNHHAVEGAIIAEYLSCCGVPDDQPAEAYKESCGTRPHASCTTVEPTSDDGSETFSPSEIRDGCATLVTANVDSAQADDGQNTQLGIFAGCTLGKEHIVSQYDWLVTDDQKLIMVYENCDGGDLHTLIAKARSNGPVHFDESFIEDVFTQICMGVEYFHSKNIVHGDIKASNVLFKGDRRPVVKVGDYDTCHVAGVRVSYTGTLMYTAPELIANPHASTSFESDVWALGCLLYELLTLTHPFASPCTVQSMKETFRDFEAHISELIASVPNTYSLVMRDILVAILDVNPTKRPTVGELISILCREKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2P3</accession>
    <name>A0A061D2P3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonucleoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0106460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766523.1">
        <property type="nucleotide sequence ID" value="XM_012911069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2P3"/>
    <dbReference type="STRING" id="5866.A0A061D2P3"/>
    <dbReference type="GeneID" id="24562878"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106460"/>
    <dbReference type="OMA" id="AYYYAQA"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="122"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="305" mass="33826" checksum="651D59DA128435C1" modified="2014-09-03" version="1">MSSSSSDRAPKASDSVGADGQTFCESDFEAFKIFAGGLNRSTTADTLRDHFGRFGTVVHSEIVADKTTGRSRGFGFVTFSNDAAMKAVLATSHKIDNVLVDVKQAIKKERARDLVPIREDVNRIFVGGISDSVSEEEFKDYFARYGTVVSYNFIVDKTTNKPRGFGFIIYDNPGDVDKAIGHHTKLGRNCEAKKAQPRPTLSKGASTPNPENFDYAAYYYAQANMMYNPYFAQMYANGQMPFFNAMYPYNWQGGENGTEGAPDGRMAGEEEGRSSREKRYHKSSDHYSSGPSRGSHRKSSRAEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2U4</accession>
    <name>A0A061D2U4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767114.1">
        <property type="nucleotide sequence ID" value="XM_012911660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2U4"/>
    <dbReference type="GeneID" id="24563469"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200850"/>
    <dbReference type="OMA" id="EHIMNIC"/>
    <dbReference type="OrthoDB" id="447390at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056022">
        <property type="entry name" value="DUF7602"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025677">
        <property type="entry name" value="OST-HTH-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24549">
        <property type="entry name" value="DUF7602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14418">
        <property type="entry name" value="OHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7602" evidence="3">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="OST-HTH associated" evidence="2">
        <location>
            <begin position="352"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="423" mass="47919" checksum="EA0F261F2D9A80E8" modified="2014-09-03" version="1">MKTDMSAYGKPGYESQLLNRQVTSRKALYGGDGNYSQLMSSISTIVDEDEQSLLSVVLETFSGSAREGTNYPEQYSDSNFGCGYAQKPVLDSVAVNDPFAELYPVDSFPLSEPVCQGEQGFRWSLSSPSSCFGTEKAQLYERLFDSYITLFNAEDSAADVPASADVPRAGAQPLSPAWEAMEALRGFDGLSISERPAVGGPRESRRKAEPTNVVDKSKSLWKRKRSKFKTLEKRAIAPLTGNDFQEAMEFLKQIVESLYRDQMPPTFFNVRSRFVEFDTKNIPVEHIMNICQRRPDVFRVETNDALNQTYIYFVKPPSYFTKWIDRNDLTDVYPEAMWDKFLDFLVELVNNPDHVMPVFPGSIYGTAKVFQKLELEFFEGMTLGVLCHVVQLAVRVRKLLMYELKTLKPNLLAILQACIKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2V6</accession>
    <name>A0A061D2V6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KE2 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0201000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767129.1">
        <property type="nucleotide sequence ID" value="XM_012911675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2V6"/>
    <dbReference type="STRING" id="5866.A0A061D2V6"/>
    <dbReference type="GeneID" id="24563484"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201000"/>
    <dbReference type="OMA" id="LGQMEDV"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="110" mass="12520" checksum="D59BC9EDD09CE1A8" modified="2014-09-03" version="1">MEGVEGKKEALKKLEKERLRLLGQLDDLSQESAEHKLVLRTLESLPDDRRCYRIVGRVAVERTVAEVRPALTTYAQKVDELHKTYNEQLNFINEEVSKITRSLGTAADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2X2</accession>
    <name>A0A061D2X2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767149.1">
        <property type="nucleotide sequence ID" value="XM_012911695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2X2"/>
    <dbReference type="STRING" id="5866.A0A061D2X2"/>
    <dbReference type="GeneID" id="24563504"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201200"/>
    <dbReference type="OMA" id="MTLMINT"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="261" mass="27726" checksum="15528724C253772C" modified="2014-09-03" version="1">MSTSGDVRSVNEIWLTAETAAISDRIEFGVPAIDSAFGGGIYCGKLTEIHGAAGSGKTQLALTLVAQVCDELITSHVEGTNGVLIYFHTGGTFPIARLCEMIEGKMQYVDPSVPADPTVVKGILKNLCIDKVTEPGELVMKLVNMYGVKDDSKNIRLVVIDSIAPLFRSTFHSKGGGKNPRSNLLQVSSFLKRLASEMDLAVLVLNEVTGGGDSALKPAGGSTTNVKPVLGDTWTQCLNCRASLQIQSALYGRATNHSQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D348</accession>
    <name>A0A061D348_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767224.1">
        <property type="nucleotide sequence ID" value="XM_012911770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D348"/>
    <dbReference type="GeneID" id="24563579"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201950"/>
    <dbReference type="OrthoDB" id="366735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="26909" checksum="12950FCA6E97BA04" modified="2014-09-03" version="1">MVGERGLIGSWDSAYYTNPFDPCNLCHKSRIRMGFKETDLPSSQQTVSILSTILTFCCGNSDPLLTLSSYLNCLTRLTPSTTGELVSFFHDFGIELHGYALKSLSLLGISLSTSHPNSPEWDRLDGTGLDTVCGIRGSESLNSTHDHLKSPHKQFGDNLGHFHRHPQLLPTIYHSHALYPLVFDYTIFHFLNVLPCSQLFRLPTRFTSSTSRQYSFTGRGYSYLATTSTTSMTPWANIVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3M5</accession>
    <name>A0A061D3M5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0109750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766863.1">
        <property type="nucleotide sequence ID" value="XM_012911409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3M5"/>
    <dbReference type="STRING" id="5866.A0A061D3M5"/>
    <dbReference type="GeneID" id="24563218"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109750"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="417" mass="46360" checksum="EBF89CB8D0CB8226" modified="2014-09-03" version="1">MYANHDEAQKCITIAKNALVKGDVEKVRGRVSALTLLQAVKFLLKAESMYPTDEAKALLAACRAKAASGSTAEASQPSSSSSRSARSGRAASSASDDRAAADGARSTAKAAALNRECLQILNSKSYYDVLGVPHNASTDDIKRAYKKLALKFHPDKNPAKRAGEAFNKISDAFQCLSDPDKRNYYDRVGSDPGAAPEKAYRARPQDIFMTPDVLFEAFFGMHPSRRAHYHRNAYEHHYAQHASSSSSSHHSGYHSTSRQSASSSSHSGGQAQGAAPTAGRIPLAFWFPFVGLLIFAFMGVFFGGEPPQYQFSNSARYSRMLSTQLNGVVYYVDPRVFERRYPPNSVDRVRLEYEVDYHYFDNKCAREKAENERKAYDYISRLQVPPKDLNDTPASCRTRESLHATYSDYLRRRTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3R1</accession>
    <name>A0A061D3R1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0203760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767404.1">
        <property type="nucleotide sequence ID" value="XM_012911950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3R1"/>
    <dbReference type="STRING" id="5866.A0A061D3R1"/>
    <dbReference type="GeneID" id="24563759"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203760"/>
    <dbReference type="OMA" id="VFDCLNC"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="279"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="468" mass="53252" checksum="442C454D87A11C3A" modified="2014-09-03" version="1">MTLKKAPNKEGATRNYITRSQALKKLQVSLKDFQRLCILKGVYPRDVARGGTLTSKGINRRKLKKDKIYYHVNDVRYLGSGDLLAKFRDISAHLKRHRKLVTRGELYDAKLVERKRPRYSLATVVKERCPALVNAVADLDDAVSTIAAVAALPANKKKGIEPKVVDMCQMHLQHFLKYVSETRCLKKTFISIKGFYFQAEILEETVTWILPHCFAQEMPDEVDFNVIATFVEYYIELVKLVNFKLYSMAGLSYPPKVKPEFAHIGNEFVYMESTGGTAVTEGLFNGMRFSLSPEVPLVPTCLVILSAGGTITELENATHVIVDRPVADVDPTKDYVQPQYVFDCLNCGILLPVQQYAIGVPLPHHLSPFVDDLAVPDRQLELDKLVKEASQRSLTNDDPDDLKTQRIRFQEDIKKETTMTEEMKQMSKALMPKKTRRLLSKIEFGERRKAEAAEKLRQKKEAIKRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3T8</accession>
    <name>A0A061D3T8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766913.1">
        <property type="nucleotide sequence ID" value="XM_012911459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3T8"/>
    <dbReference type="GeneID" id="24563268"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110250"/>
    <dbReference type="OMA" id="LDNNYDA"/>
    <dbReference type="OrthoDB" id="366367at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43028" checksum="C127C1DDD4EC2C29" modified="2014-09-03" version="1">MGGRFCPAKALRSVRAICSANAAASIRQNAHISSYLPFTPLNAAGCARRCWSSGREASSAADSCAQVDTARDKVVSIGHRFVKDSTPEKLLELTSTYWRKLRYFKPLLLTCNVDKAIECRVADAVLASGAVFQSAADIPQLSELMAQRKDSHGFVGCYINVDSADSLLESRKEIYETLDSGCNAIMVDLNLRNAIPAQDLVRIDEMLFAIKPHIIRFVGNTAYFAAAVASDNEAGYSAGGDKEGQPDSDIARLNRCKVISERYNAVVIDNDLHAVVMNASDHEGAVFSRSPDILKKVHGGFRKYAPFYLVQGFEVSAGGIIATMIAVSSSKPMFAAIAAIVGIHYSAIKCVDMCNGPGSLGVTFVDMMHRISTSPDSLLQHDAPIQFFKLVDLASQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4A8</accession>
    <name>A0A061D4A8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0205710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767599.1">
        <property type="nucleotide sequence ID" value="XM_012912145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4A8"/>
    <dbReference type="STRING" id="5866.A0A061D4A8"/>
    <dbReference type="GeneID" id="24563954"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205710"/>
    <dbReference type="OMA" id="MKEVDQV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="225"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="527"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="717"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="143"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR95413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1174" mass="133479" checksum="D0D7A6EBEB559522" modified="2014-09-03" version="1">MVLDGLSELQSLSASSKVAQILKNHLDLDNSDLVEFIIHLAKKAKSAADFNRLLDENEAEMPTALGEQLFNVVRTLDPPKKNKETWDDIIAAENDERLNFPALSMRNSDIKNDSRHKIEVKKEGELSDWAKELLKQETGQAYEDDRERDSRRNRDVQRDRERDGRIRGENVRVKDDRGSRNDYKEGYRRDSYRSRADDRDRRYRSHERRSRSSSGERTPTIDIKGQVFLGRVNRIMEYGAFVSFRTKTGRHVGLLHVSEILPGKRRLLDVREVLKENMEVYVKVVAVNGDKVNLSMKTVDQHTGKEDSSRTTSSISEDTQIRRVHTTMMGESTNAPLNSYAHGVEGRKRRMVTDLEKWEQQQLINSGVLTKGERMGMNLNADRDAIEEEEEVEIEINEACPTFLKGQTRRSGIELSPIKIVSNPEGSLARAITTSSTIARERRDAERAQEDRHIIEARRDDATAEGLNLRQGGSSTAQFMMELQKANSMHKREHAPGDRGQQKQTTLVSIKDQRESLPIFSFREDLLQAVRENDVLVVVGETGSGKSTQIPQYLAESGYNCGQNGSVRVIGCTQPRRVAAISVAKRVAEEVGCRLGQEVGYCIRFEDCTTKDTMIKFMTDGMLLREVLQDPMLERYSCIMLDEAHERTIATDVLFALLKECCANRNDFKLIVTSATLEAEKFSAYFNDSSIFSIPGRMFPVEILHTKEQESDYVEASLITVLNIHLNEPAGDILLFLTGQEEIDVACRTLHERMKRLESMSPPPLIILPVYAALPGEMQSAIFEPTPPGCRKCVIATNIAEASLTIDGIFYVIDPGFAKVKRYNPRTGMESLVVVPISQASAKQRSGRAGRTGPGKCYRLYTEDSYRSEMLPTAIPEIQRTNLANVVILLKAMGINDFLNFDFMDKPPVETLIDALDNLYHLGALDDEGLLTRLGRKMAEFPMDPNMAKMLLTSIDMGCSDEIITIVSMLSIQNIFYRPQDKQAQADRAKSRFTQAEGDHLTLLEVYNQWRRNKFSSLWCHENFLQSRALLRAQEVRKQLISIMDRYNFKVTSCGNDPEKVAKSVCAGFFHHSARRDPQEGYRTILDQQNVFIHPSSALYNRSPEYVVYHELVMTTKEYMRDLTTVKAQWLLELAPSMFKKCEGVSKAKMGQKIEPLHNKFEEKDAWRLSKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4C6</accession>
    <name>A0A061D4C6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0207460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767777.1">
        <property type="nucleotide sequence ID" value="XM_012912323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4C6"/>
    <dbReference type="GeneID" id="24564132"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207460"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600028" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="832"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="961" mass="108159" checksum="BA85824C73B26F1A" modified="2014-09-03" version="1">MRKIRILRAVCALCAIGLHSIGHIHASDNSLGIGNDLFVRYALVTQLMDVDQSASSYIECPRRVKDTEYVWHPQPTSDTLPDIKAYVVEDGKFHSTPLSEVIISESRIPYISLHINETESKLYIDLHIAEVFAITKRRLVFICGPRNLVLTDTLQHQLYQLNGSTLKGSFPWDVNTTLTQEIMKIGTGLAMFSLLTGRFQTLLQGCGSRPSPLFLPSNDVTVDRSTGVTSCVVDPMSPLRIGFVCEGRIEPKGCMKSLLDEHGRVVTVTEPHLYWNVAKNAHWVAAMFFHTVALPPIKGECRCVDPKTGNTKARIEVRSRTDYVCDIARKIFRNRHRPIRGPWCSVVLHPGSTLTIKLPMQSVSSTSTNERSDEDLRMDVEEDVSSISFSQLSSVYEYESEFLPTNVATMRQQSVSYDNTYDEKLYHNALVGDAIDIDVSQISRGEVKLKYHRDKPLTLRRGLNSFYYHWTLVSRNDNVPDMIRAIVNVSFALTHNYAMLGSDVHTQSLFDPSISQYHCSVQTMGNGIGRVYECLYQDVAHVTDVGIHCGSEEELFPNNCEATAYDLYSNKIVLFPGSVRNATLFPIRGFQLFKVDFEQNESVSLACLCVDKRGYEISRMIMESNQYIYRSCDVKQEEPSNSWFPFRLIPWSEFQLLDQNRSSIPVLLNNVTKKFITLNVGTQLAITCAGSPGDLNVAGNLDVNPMWLPIDAEEFHYAVRLTLHGHELVRTLHRDVIGGTVDAFLVSQIHLLTDFYVQLVIDSRRGGIIISKHPDDTAYVPLTFVCGKTPNISEISMVPRSRYNVTIPHGTLRLAPYTWHVVEVNVETTDPYMQGCGVTYDSDELFKPATPQLYDSYRQEIGCKIDIQSAKEAAFYCPAPYVLDPPDCFNQVLVEGEVKNLSDISESLAASHSNHFVILKFHSGSIGPVETLRKTPPLECRCVTIKGIVLSTIHIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4J1</accession>
    <name>A0A061D4J1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaK family domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0207950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767827.1">
        <property type="nucleotide sequence ID" value="XM_012912373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4J1"/>
    <dbReference type="STRING" id="5866.A0A061D4J1"/>
    <dbReference type="GeneID" id="24564182"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207950"/>
    <dbReference type="OMA" id="LNTMERQ"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="882"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="768"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="936" mass="102747" checksum="4EB8059F972D1A9D" modified="2014-09-03" version="1">MVAQAILRPTGRLTPVGFGMALLLLLFALIYRAEAQHATIGVDWGEEYVEVAIAFRGHKPDILLNDTGSRKFVNAVYLDDKTRFFDQKAAANVVKNPSKTVHKSAHILGLPVSVDGAQEVTPVPKEQVLGIFNDKGFVFDWDYAPYEFGADGAGQLYLKITKEGMVKVEEVAGHFFDYIKGIVTNKLVASKVIEAAETDISIMAVVTIPCNYTQHQRKAIIFAAESAGITVAGLVHGITAASIVRAFEQEPGTKKVLFYDLGSSGANVGVVEINVPEKDRKKSKGISDTQITMLSCVTLQGVGGRHHDVALAQHLRAIFEKKTKIELMPQHPNALQKLLKAANKAKIALTISGATNVAIDGLIRNVDFTSETVTRQTFTELISGSIAQLENPVKRALELAGDLKLEELDGVELVGGSWRVPAVQEKLTEILKPHPLGFHLNAEEAMAMGAGYLAAVHNRFFKMKSANVAENSLHLYAIRIFSIDSTHPDAMEKSSPLFKPDSKLQGSKSVVFKTNLDFQLDLTENGDLITTYRITGITEVMSKEENKGKVAQITMVFGANATGVIELSRKSAVIVEVAADDASNASQPAAEGTAEEAGERAANAEQAKEAQESKEHDKADSAKEEQAAEPESKESSDAEQTTESGSEDQGNRENKKSDDKAEAGKEADGKAEDKKPAAPAAFELHTEVINRHSSFAPEKVEEAIAGIKARNQRDMDIARLSERKNSLESLIYKYKSAARKTEFQEACDEATLATINALLKEYEDWFDEDSYDATLEQFEERISKLEEVSTPVYQRWSDNEARPTLIASTNKSIAKLMQKFDELLEKKPYIAEESEMVDRFKSVQTWWEEVQKQQEALKPSEEPAFTAASIKVRMEIAKQVLASLQKVPKPKPAAEEKTPEEAKEAEPTAEEGAQSPEEEQPADEKEEPEQTPTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4M0</accession>
    <name>A0A061D4M0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mic1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766075.1">
        <property type="nucleotide sequence ID" value="XM_012910621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4M0"/>
    <dbReference type="GeneID" id="24562430"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102180"/>
    <dbReference type="OMA" id="CQHFANL"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mic1" evidence="1">
        <location>
            <begin position="529"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="704" mass="79307" checksum="9F2EFAB18ED72939" modified="2014-09-03" version="1">MAEVVVFKELYSWQSDHDQAVFVDGANEVVIYQSVYDKSIRVIDSATENTIFNNARYERGQAVTVTPNQPLCEVIAFSADGRLVLYWHNHPLAIGIVNGFDVDSDDILVDCTPYEETIVLNIFWLEAGTNGTYDFAVVCTTCIDIYSYSSSNQVLRRVCSKRISCTDVWNDVSGTHVIVLKSNQVLQLYRLINKEVRAVTDIELAIKSEHKLHKSSIIVATIYNDTYCIHKDASSGTISLRSLRNSKAVDIVLELSCQGWLEIAILDNVVLALTGGGETYLFDIAMTDKRLLARVPQSKPAVASMSSDVQAFIPNVVVDYYGGFAYNIAIDHNMLMLLLSQKYAEPLVADFYQRRIGSAQRVLDIVNNAIENKSPRMRANKLLVLLSTIVAPYAKVLVDLNKLGTRTEKNVAIPFNLVEEYIGQRSVISEHRFAKTIIYAAVAKEWNLKPGENVFDAAIALLCHHRRFDHSVLVNIRDELEIQPNPVNNFILKSRLISSTKEDISADFRDYVTLHGAAIPNPHDRSLRNRPYIIVVTLSYLRALVAHNLQPTNVLQILLLDMCVLYNNIDLALQLIRSKNIRDSAYVCYRLLYLYVVLRDPALRQICLDMAIRLKLYGICVKIAVIDEDYYSALVVMKAHGVASFPMHRILYCAAKDVEAQERKPHLWPSMLAFIKSWAEESATDGTSCAPPNLRGCEMWLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4X3</accession>
    <name>A0A061D4X3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0202540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767283.1">
        <property type="nucleotide sequence ID" value="XM_012911829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4X3"/>
    <dbReference type="STRING" id="5866.A0A061D4X3"/>
    <dbReference type="GeneID" id="24563638"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202540"/>
    <dbReference type="OMA" id="AGWYCEA"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="232" mass="26361" checksum="60FC4CA2269C413F" modified="2014-09-03" version="1">MAAENVDPPQGKPATNVDALGRKVWDKSYYAQVAEKKTGGQGDSVEQSIATLLPDPNRKPVVAVPEVRENLKRRKETVDVTKDVGKVRVISALTHKSQQGGFYCKVCDCLLRDSQAYMDHLNGRKHNRMLGMTMRVEKVDAKTVAQALKRRAMQENAPKLSTEDLQKDLQERIKELEAEEREMKRKRKMNKKLKQESKNISTKLKVEDDSTENVETDQTEMLMRSMGLPTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D549</accession>
    <name>A0A061D549_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767879.1">
        <property type="nucleotide sequence ID" value="XM_012912425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D549"/>
    <dbReference type="STRING" id="5866.A0A061D549"/>
    <dbReference type="GeneID" id="24564234"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208470"/>
    <dbReference type="OMA" id="WRIYTEA"/>
    <dbReference type="OrthoDB" id="361918at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="325" mass="36121" checksum="A8B42EBFA26BB444" modified="2014-09-03" version="1">MGIPRQWQPHEVLAYIMDAYDQLLDWDDVLDESNNGGDASSDAEDARRDHVEWCRQIGLRKFVLLFGDSGIAVNEIPLQYRRTADPSHAPTAGAQSRAHVVNEQPDAMALMIFETEAYAMQFWAAMASNCIKAYPSTIVVAPDPSGWRIYTEAIALWFNGEVMGQLAPAQVQNNLAKDKQNDDLLAVLTTNKAQDEGTTKQKTIPQLTFVSPYISNPDDANEIANALTKIGIKCMYHKPSKIMSFQFPNETLFSTLALCHRFFISPSGSRVHCCFIRCLGKFLPVVKRTNVEHLSSSIEKSKTAPPKPCKFKPPSVGIVTIEGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D556</accession>
    <name>A0A061D556_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S24 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767368.1">
        <property type="nucleotide sequence ID" value="XM_012911914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D556"/>
    <dbReference type="STRING" id="5866.A0A061D556"/>
    <dbReference type="GeneID" id="24563723"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203390"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="OrthoDB" id="10251131at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="135" mass="15684" checksum="66EBB3BDC3799846" modified="2014-09-03" version="1">MATNDQFSIRVKKFMTNPLLSRKQFCLDVLHPGRANVSKSDLRDRIAKQFKIKDPKTMVLFGFKTYFGGGMSTGYCLIYDTVANLKKYERQYRQVRLGLEEAPKEMGRRAKKELKNRRKKVRGKEKAKCTAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5D7</accession>
    <name>A0A061D5D7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768107.1">
        <property type="nucleotide sequence ID" value="XM_012912653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5D7"/>
    <dbReference type="GeneID" id="24564462"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210710"/>
    <dbReference type="OMA" id="LAPCKPI"/>
    <dbReference type="OrthoDB" id="366283at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595992" evidence="2">
        <location>
            <begin position="31"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="418" mass="45974" checksum="61BE1930847665AA" modified="2014-09-03" version="1">MYRPSVRASARCLLIALFLVIFAWQAPVSAVSNRRHGISTASPSYRISPRQASAARPMAMIKAETPLVKPVSVVVHTFWGKESCFNTQLRLDCAVTDTGHSIKRAVSALTGIPVCLQRLFVSESVWNLGTRTKFADNDQISDFPALLRLRHDTKQPELHVLLEIPVPYSHNLRSDAGSIAEYAAALKRYSSLLSRVKAARKDPKLLLDPELPREDQAPDTDARTETYPSTGRVGAVDEATVGRVVERNGCALSPEGAERASSRAADGLKGSFVTPIGNDTVARAAAVCPATNTKRPTATGSGEAGTFVSPNRRMHLLFFHDYPTPPGGVGGRLRQWFHQQLPIDWVTNAKFALLCYLTRASCNNEPWVKKALLYAPPVGLLCQTRLGRLLCRSAFHMLPMEKLPKGWFDYVAITLFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D668</accession>
    <name>A0A061D668_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0211950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768239.1">
        <property type="nucleotide sequence ID" value="XM_012912785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D668"/>
    <dbReference type="GeneID" id="24564594"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211950"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="165"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="293" mass="32750" checksum="EA49BEAC14C8446D" modified="2014-09-03" version="1">MLHSIPHRPLKLHSGTEFSMRCVLDHTLYNGGNDGGATPTWFPYYPGYYHYKVDTTVEGDMLIPMRNEGRIAGTKCGLDIIMPESTDEHCDLMIKSNSGAILVSRDPDHSEYVPMTFVCGKEFSESDFDQSINDAYAAAITLALTPLEEYTWNVVQIDVEMTDPYMQGCGITESRDTLFKPETPNIYDADGREIGCKIDIQTAKEAAFYCPAPYILDPPNCFDQVYVNGEVKDLSEVSYSLVASRTNHFVTLKVDCRVVGAGEMLRQTPPLECRCVTIKGVVLSTIQIENYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6E0</accession>
    <name>A0A061D6E0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0107970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766685.1">
        <property type="nucleotide sequence ID" value="XM_012911231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6E0"/>
    <dbReference type="STRING" id="5866.A0A061D6E0"/>
    <dbReference type="GeneID" id="24563040"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107970"/>
    <dbReference type="OMA" id="NIWPPLD"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2130">
        <property type="entry name" value="DEAH helicase family, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042035">
        <property type="entry name" value="DEAH_win-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="55"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="465"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1130" mass="124709" checksum="B3BEFEE211F29D7C" modified="2014-09-03" version="1">MAKSSKSAKRAKRAHSDTAPTRREPEYNVVHVERLLEVERRRIKLPACMMEQEIVDAVKHNDIVVITGDTGCGKSTQVPQFLYENGLCTDDGIIGVTQVRRVACLALYQQVSLELNSKTLVGYQYRFNRGFNQRLCKIKFMTDGILLQEIKEDLLCTRYSVIIIDEAHERNLNCDILIGVLSRVVQVRREQFEAGVPGVQPLKLVIMSATIRAEDFLEAKIFNGKVAHLHIATEFKRNTIHFARRSVRDYVADAQDKVLKIHQRLPPGSVLVFLTGKDELYRLKRLLSPYEQRASAAPSAATQQPEEPDDDDAIFELESDSDTEDEQGRRSSNKDDSGDDNMYNDDNDSGNKEKQPGADGSDEKAEGLDAVATDAAPVANDENQDADSVQERGGESGVQIHIHGITTETGDHNMVALSENDRSTTVSDSTSSGDRPDPSKYSNAETDLKESKDEEDGANRGQVTDKDDIGDVAEDEGHLDAESSRRVITGDSDTEPEDEAEKAYHVELEVLSRNYKRLSDIKWHGSGAGAGTLRVVVMHASQTMDAQMTAFTLPSDNERVVILSTNVAETAITLPNIRYVVDCGKEKRRVDDISRGVSRFVVCDISKASAGQRSGRAGRVGSGHCYRQYTSSTYETLFDDYSPVEIANCNLESTILLLSAIGIENPYDFPFLTPPPLDNIRSALQALAALGAIETPRQLAESRHSAQNEVTANPFKIPPSYPYKTSYEVLERIRAARITQLGRYLALLPLHPRFGKMLYSVVSRGANADDLRTACCVISALSFGAANLVNPRIPGGDDNRKPIPSLRSDVELFIWICCRYSQTTGNGGSSFCSQYDINERLLREVFQQAEQLYRAVRASLGSQAQHLDADWSGPLSTPNRSAKQIIEAAIVECLVDKVAVHASRLSNDAHAAATNAYRTSALTALRRDVFLPRTYSRHKPECVVYVGLVGDEKIKMQDVLPTDAATICTLRSPMIVANSIHKALPPRYNAEHDCVEAFVNKVYAPLEFPLGIAKAALNPDHPLATRTFAQQLCLGNVFPALRQFSGALIVSEADFLAPTKAKGPLATLLLALRRSRVSSRATFLAASQQDANFLLHEFRGIIRAGHADHQAVEEAFRSIREDRVYGATQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6L9</accession>
    <name>A0A061D6L9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768502.1">
        <property type="nucleotide sequence ID" value="XM_012913048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6L9"/>
    <dbReference type="GeneID" id="24564857"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302200"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="7024" checksum="8A4B1E22DCFCAEEB" modified="2014-09-03" version="1">MKLPQNSTHDGSYDESHDYYDGVNYNDKIKKQQYRRVKGKRDHASQVLLSVASATIQLSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Q1</accession>
    <name>A0A061D6Q1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0301320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768414.1">
        <property type="nucleotide sequence ID" value="XM_012912960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Q1"/>
    <dbReference type="STRING" id="5866.A0A061D6Q1"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="GeneID" id="24564769"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301320"/>
    <dbReference type="OMA" id="FYYNYRH"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596022" evidence="3">
        <location>
            <begin position="17"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="497" mass="56201" checksum="223665A63C9139D7" modified="2014-09-03" version="1">MLFQVIALSMLQIARCKEYLGGSIATIGPDTFGMMPQYHKLLADNSFNYHGGFKNSTYAAAKKDIRQMEVKMLSKYKEVNAILLSTSRFYYNYRHVGNLVDVASALYKLGLLPRQQLLSLAPETCLCHPTNTFPGRVYVEKSVDITDYKDEVSNDVTNNFLEHMYIPFRSSGLRLDSLRFLMTQRFPSKYPQSSRLATKYRVEVDGVHADLDLPTQFVYMTGHGGDRYFQFQAKDVLSANEIELYMTEFFIKHPNVHTLMISDTCQASTLFEGLSNQDPMVWVASSPRGVSSYSYNANSQLTVSPVGKFTYYVAGFLCSVAKGIKERKDRAAVSRFSFNQLKRHMERHCPEEMSVFHANASIMGATSADTGQFTPTINDTTSSKPDVRKIYLGEFLFNYRVSYFNTYSWPLMLYSMAGDVVALKGQMYEAFNLNTAEALSINRHRLYTKMGENGLFVRTVIESSGLSIVLALLLCVLAIILATLRDPVTVGNLFVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6U1</accession>
    <name>A0A061D6U1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0303200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768602.1">
        <property type="nucleotide sequence ID" value="XM_012913148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6U1"/>
    <dbReference type="GeneID" id="24564957"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303200"/>
    <dbReference type="OMA" id="IEKTDCW"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="107" mass="12133" checksum="ECC620CEA2EFD59A" modified="2014-09-03" version="1">MSLSGKGFRHFASLQRELADAVEAKINAIPFHINRTASGNLAVFVKHRNNGNLAYTYVQKVRGNRQILKQEIQELVGNRRIVDTRNAFVIQGNHKNLIVKYLKSIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D740</accession>
    <name>A0A061D740_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger A20 and AN1 domain-containing stress-associated protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0304350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768717.1">
        <property type="nucleotide sequence ID" value="XM_012913263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D740"/>
    <dbReference type="STRING" id="5866.A0A061D740"/>
    <dbReference type="GeneID" id="24565072"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304350"/>
    <dbReference type="OMA" id="VLCENNC"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="18346" checksum="3FC9C414CC987F6F" modified="2014-09-03" version="1">MNSEHNEQAMERPVTSPQAEPTLCKNNCGFYGNAANDNLCSKCFKDQEKVQSTPDDYFEKDISFMDASTAVEPATESVPSEVDAKPAEDSSPVASEAPVVPDRCHKCDRLVGVLGFKCRCENYFCAHHRQANLHDCTFDYKGMFRSLLETKNKKVVRDKLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D755</accession>
    <name>A0A061D755_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766935.1">
        <property type="nucleotide sequence ID" value="XM_012911481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D755"/>
    <dbReference type="STRING" id="5866.A0A061D755"/>
    <dbReference type="GeneID" id="24563290"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110470"/>
    <dbReference type="OMA" id="VEPWINK"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="309"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="564" mass="62977" checksum="54F3873F7FABD949" modified="2014-09-03" version="1">MQSVGARRGRSKEHSSAISDNGVDGSVTDRDASTYSLRCNPIEPMMAQQSPSIGFNRVTSAGARGSSSFDRSSVAADLGISEDCAPRHSDHSGSGEFSRSGSWPGVIPDDLEHMFDCTLNLTNIKRTLEPKDHRPYSDQRSSRFVESVSRTFNKRSEVTSPRRAVAALMGLQAPKDKSGLQWEHFIRALRIKRWSQMLVNAQKRESPESVTDTAEDETGDNLVRRNCSFVEVVNDASAAKGLDKLVGPQASRSLRPVTTSTQYARFRPRSVGNGAERRVRSSARRIYEESTPPAIVRAGHRPGMDAVNYGLVRIREAGSSVQVYDCVEKETGRMLSVKLISRDHSAAALYEHLCEHGHPNFVTIVQILEDKNLFYILMDFNNTVCLREFYHDSHPRTFTEELIRSIVKQLLAALAYIHRKGMVVAGLSMESVIIHKTTDGELVAKISNLDRVCPVMPEQVNSIQDNAFDAPEVADGVITYSSDMWSLGVLLYTLAEGRPPFKPFTAKSYVRRAAAVRGSRLTFASEAWMDAPRMRDFCLRCLQPDHRHRVSSAMEAFIHPWIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D771</accession>
    <name>A0A061D771_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate-acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767993.1">
        <property type="nucleotide sequence ID" value="XM_012912539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D771"/>
    <dbReference type="STRING" id="5866.A0A061D771"/>
    <dbReference type="GeneID" id="24564348"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209600"/>
    <dbReference type="OMA" id="YTHFKDD"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="593" mass="67837" checksum="DCDDEDF53C13A677" modified="2014-09-03" version="1">MQLSTTDFRVFNFYMLIKWLTTVIIRTFFMKVTVINEERLPLFGPVILVGNHNNQFIDAATLIYAVPRQISFLVAMKSLGRRVIGSLARLAGCIPVHRQEDLKYMGIGKIHWKHNDTMIRGMDTQFTMDLNVGDKLYFIDQKLSIEAVHSDTELTLQRPISRPCKDEENGEDFWILPKVDLSDTYEAVSTALRFGNSIAIFPEGGSHDRTNLLPLKPGVVLMAIFSLLEGAEDVVILPVGLAYGDSHGIQSNATVYYGTGITISKRDVEEFQVDRYTVVNRILGVIEKGLNDCMITAPNKNIKGWIDLCGSLYPPERSLIPTNKKFELRKILSTIFWRHGEDANTIALIAQLARYKAMLKSSFLHDDEVWLLRQSMHSATLLFLEQLLMFGCYSILGLSCFLLWFPLYVISWVLAENHRKQALKNSVVKLEGADVVASYKILVLMVITPLFNLFYGLMLGLYLSRNPKEIAITVGCCMAILPILYYINLRYFNELPLLLRQLRVFYVILMGKINVWRENERELITTRAELQLLVREFVHEVGPKVSDTFMDELNAIMPKVMIDADTSRLRRSKSDWVPIFARTYYSDSNEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7B3</accession>
    <name>A0A061D7B3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutathione synthase</fullName>
            <ecNumber evidence="4">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0210150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768048.1">
        <property type="nucleotide sequence ID" value="XM_012912594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7B3"/>
    <dbReference type="STRING" id="5866.A0A061D7B3"/>
    <dbReference type="GeneID" id="24564403"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210150"/>
    <dbReference type="OMA" id="FEAHKNM"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="11">
        <location>
            <begin position="345"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="678" mass="75093" checksum="59F775C180959FAA" modified="2014-09-03" version="1">MSIYYVDQPSRRFRIRVPVRLEVAREDGSYVFPHITGHFMDVMNLIPSGCAADSPEFSGIYRCHSADVSEAVEQLLKSFVRKLLMLGCLSQNMSWKATCKVGSVIPFGGRMRVAPTVLFPLPFPLSPFLAGVRFTPSLVRLIDHVSCNEQWLSSALEPLREVDPFMAQLLDICRDVYLSGKRRLRDDVRAYITRADYLLHLAELQSAPSNASSSGRMEHCRTCHYDVCLCELRNIVGGTIGSNAGLMRSFETLPGVYMRMVEVNTVSCALAHLSELVSRAHSDCVDGMLRQRLAIGKMDHMGMISGFHKLHLQNSPLGGIVDTLATAHEHYVKRHCSLMHDMPPCILQVVTEELGNFFDVYAVADVLVENYGVTVKVVTMRELCRWRREGRLFVQTASDSPVHLVEPKRQFNPDSEGNPGRLFIACPPLNGSGQNEVIVREVSVIYYRSCYSDDEMSCDRDSWDVRRLFEFSDAVKVPSVPAQLAGSKRIQMLLCDPAVRAQLSTEDTLPPDVSPTGASISPVSAALNTFRSVNVQQVDPSLDAHEEIVKAAIEAPAGFVLKSQAEGGAELYTHDKLAEVLRNGMENDRRQLARYVLMRRIKPPVQRAAFVKGTEEDGFTLSVERTVTEIGIYGCAVFSGKRVLAEECSGYLARTKNESTAGGGVCAGHAAVSSLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7C9</accession>
    <name>A0A061D7C9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768068.1">
        <property type="nucleotide sequence ID" value="XM_012912614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7C9"/>
    <dbReference type="GeneID" id="24564423"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210350"/>
    <dbReference type="OrthoDB" id="369837at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="274" mass="31511" checksum="81FD98A3A54B64DA" modified="2014-09-03" version="1">MAPLKAHCVRASALVLLLTQLFLLQWLPVAFGHLRRNSSHLRLYELRNALRNDFANYDIRNPAVQRRKFALCVVNADAPSAQKADKPGILGRVWNTYAKIKDVVDRHIQKISDNRKKALSSTHPLRHQSWRITFHRKTGLLGLSTRTEHILIDFMEDGTLKTSEGHDGKHFEMTNKQQSAGNWWSEYGDVVWKIYFDPKSNVATYFNAQFSWNNFGEAAFMRRGVVYQDRPQDGWLPQYLFRPVIGKFTGEGIPQDDTNSPVKSRFDGEVSHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7F0</accession>
    <name>A0A061D7F0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0210600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768093.1">
        <property type="nucleotide sequence ID" value="XM_012912639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7F0"/>
    <dbReference type="STRING" id="5866.A0A061D7F0"/>
    <dbReference type="GeneID" id="24564448"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210600"/>
    <dbReference type="OMA" id="RKFLAWC"/>
    <dbReference type="OrthoDB" id="365783at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="690"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="719"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1015" mass="110781" checksum="136928A36908209B" modified="2014-09-03" version="1">MSSVSFRISRHPCWVFSRSASRSASRGRRSGRGRSDHSARRRGDTRSDRYSDVHSERMRAYGSTALSRSHSTRKSGKNSEQIVGGVGQDAIALKTDTVEVRQVDRTILVGAKRTTHSDASAKQRSFVQEDSDDASEEGEIVEGIVLDEDEQDVEKFLEHRRRERQKLMERLTSESRRGSTSATCSIDPNDVSAAAAAPDGNALNTKPENSHAVEESVASQLQKRLVASGCSTTPEQAAGADGVSLSRPSEEDCLGNVDKTATNVSDLRHPSVELANAPAEHESVPAVATAVSPESKPMYGYRAFVAAPSDGDKIKDASANNTDARGPSTPVTGGSTGQPLSANSDGAAATSSRLATAPTLERPSKRRNPFTMFLSRLGSPQQNAAADPPKPACPDFTVLCTQAASGVTSMQSNEATENVTNQHSEDVSLNNGGTLPSEAAPVEHNDAPPSDRQEPASPRGQPANEVAAAEIPVNGTDDAVSTTEHAVASADQPLVESNAPVSSVEVGVPLPPVFAMSSENIDDSHISDLTVSDIDEDEPYPASVPAAAPKPSASAIMNALQSEIMEQKVKLRNMMLKMREEHKSGFYEVGSSVADEYALQDDVGDGDSSTAAHDDPSAADESESGDDSDDDMDMFAEVDDESKSAKEPSAAKRRKRPRRAPAVRGLSDEWNDAEGYYQATIGEVLGNRYRVVSEVVGKGVFSSVARCFDSESNVHVAIKVIRNHEIMVRAAEKEIGILRRLNESDPDDRRHIVRLLDQFDYRGHLCMVFPMFWGNLRSALRLHGKGRGGFSLPYVHSYTRQLFIALRHMWRNSVMHADLKPDNILVNEDFSRITVCDLGSASDVSENEITAYLVSRFYRAPEIILGLRYDCKIDVWSAAATIYELATGDVLFAGRTNNHMLKLMMEVKGKVPNRLIRAGQLASQHFDENMDFVYVTRDSFTRKDAVKLLRDLRPTRNLTDSLLERQPWIKANSPKKEAMVRKMRQLGDLLERCLAIDPAKRLTPEEALQHPFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7I7</accession>
    <name>A0A061D7I7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RIBONUCLEIC ACID BINDING PROTEIN S1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0305700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768852.1">
        <property type="nucleotide sequence ID" value="XM_012913398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7I7"/>
    <dbReference type="STRING" id="5866.A0A061D7I7"/>
    <dbReference type="GeneID" id="24565207"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305700"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="25519" checksum="013CC62DEA1EA9B7" modified="2014-09-03" version="1">MSDCMEGKQPLSQLRSLTFALGRLAEAQISGRLLVATASVVLHLGVSLSDIIPKDVPVACRCLGTFDTLQQLFVFFFVRMNQMRRLRQTLYRLNNFRSNCVCLVFAAYGLLFRRKRETFQRLTGAATPAVTMSDRSSMDEVAVFVAPISPNVSDDHLREIMGNFGHLCGVEISDVDTPHGATRIARIAYESTESVESAIKHMDKGQIDGLRVRVTAKRPEPRDIPKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J4</accession>
    <name>A0A061D7J4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767040.1">
        <property type="nucleotide sequence ID" value="XM_012911586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7J4"/>
    <dbReference type="GeneID" id="24563395"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200110"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="95" mass="10193" checksum="FBE34F7276F3C6B1" modified="2014-09-03" version="1">MGIVNRQLAEGVRGIMLSSKLGQMGNCLGCSKPQCKGDNAKCRGIAFACVLAGTILLIAFVVLVFYTLGIFHNKSLGTIFAEIRDGFRSSKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R6</accession>
    <name>A0A061D7R6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0306350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768917.1">
        <property type="nucleotide sequence ID" value="XM_012913463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7R6"/>
    <dbReference type="STRING" id="5866.A0A061D7R6"/>
    <dbReference type="GeneID" id="24565272"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306350"/>
    <dbReference type="OMA" id="NHKGPNG"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="190"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="654" mass="74318" checksum="CFB6046EFCEE6FAA" modified="2014-09-03" version="1">MANTKDAARHNATLVEQKGRQQQVIDDLSSSFKRINLEHLSRGSNYDVKGYSSYSHRHAPGSARNEYHKLSHMDRYGKNYVIRDKYTHGYGGMAPPPKFLSANIDSERLKALDFDSSSKTDSINSLCSDINTLSSQRGGIDSGIDDFTDSSEGGNTDAFDCTLSESEDGDAYVVGGYHPVKIGEVYDGRYRIEGKLGWGYFSTVWLATDMRSKPMTFVAIKFQRSAQNHTEAVRDEMSLLKKVRDQVISRSWIRTKRSYRQALGNMYNPTRGVVSFLNSFKVKGPNGTHMCVVLEPMGPNLLSLIKLYKFKGVPMHLIRKITAHVLLGLDYLHRVCGIIHTDLKPENILVTSKLMGRTPVENPDLDDPLRNPDIRPQKLDIPYVKHLIRPSCSDPSCTTSYDTPHALQEAVFRKPYDHIPFKITQPLRNSQAKAAEMAMYHPWVAEYVGYKPTVAGLRKRPVVVKTQQGPMQLKPVDVSFYDNPSAIYKICDLGNACWISHHFTNEIQTRQYRSPEAILQVGYDQSADIWSLACIVFETVTGDYLFDPHGSTSHDRDINHLQLIVELLGPIPRWMLKSSTRFRQYEREINDVKPWPLESVLMIKYKMSPLEAHELSQFLLCMLKTNPKDRLPADTLLHNRWLNGMPSRTSTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T0</accession>
    <name>A0A061D7T0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Histone deacetylase</fullName>
            <ecNumber evidence="1 4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0100990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="1 4"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765956.1">
        <property type="nucleotide sequence ID" value="XM_012910502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7T0"/>
    <dbReference type="SMR" id="A0A061D7T0"/>
    <dbReference type="STRING" id="5866.A0A061D7T0"/>
    <dbReference type="GeneID" id="24562311"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100990"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000010">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF44">
        <property type="entry name" value="HISTONE DEACETYLASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="450" mass="51039" checksum="4D53EF7366D39F82" modified="2014-09-03" version="1">MEKRVSYFYDPDVGSYYYGPGHPMKPQRIRMAHALVLSYDLYRHMEVFRPHKAVEPELLAFHDNDYIQFLSGVSPENYREFAYQLKRFNVGEATDCPVFDGLFVFQQSCSGASIDAAHRLNNQQADICINWSGGLHHAKRSEASGFCYLNDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKFGNFFPGTGDVTDVGVASGKYYSVNVPLNDGMDDDSFADLFKVVIGKCVEIYEPGAIVLQCGADSLTGDRLGRFNLSNKGHARCVEFCRSLNIPLLVLGGGGYTIRNVARCWAYETGVVLGKQDEMSNQISLNEYYDYYAPDFNLHLTPTNMPNYNTPEHLERIKMKVIDNLRHVERAPGVQFAHVPPDFLQYDDDEDEAAQQEVFDEGGGLATSSASELRGPSPPIYVNHRLRRKDYKNDYYDLPDRDQQVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G2</accession>
    <name>A0A061D8G2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768448.1">
        <property type="nucleotide sequence ID" value="XM_012912994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8G2"/>
    <dbReference type="STRING" id="5866.A0A061D8G2"/>
    <dbReference type="GeneID" id="24564803"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301660"/>
    <dbReference type="OMA" id="KFRIRTK"/>
    <dbReference type="OrthoDB" id="361858at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G patch" evidence="1">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="449" mass="51188" checksum="08679EDDF3B877CD" modified="2014-09-03" version="1">MKADKTYDNVVKGSLKIKGKAITKKKKTVDVEVTKPKDVIVVEKTQTEPQVVPDDDLQKKIQRVIANDSLTPSEKTFRIVQLQRNAKKIEDQLKKTHRERVEIFNQKLSKLSPLTRKVGKMSTATFLGTPLSKYEIDDIETDLVHKRAQNFEKSKELKYRQNREQIKRNQIITHYTVDTAEGFVPANFKSSKTNRASYKQQEVSTFTDLEDAEITTKNTLKAIKIDRIGLRRNVATILATLGFMGKKRFIGPINIHAPQTRISSSLEGVGFTFDVDKGVGKLQFVNATNDDYGPQWRHHAIQRSTEQMASLEGAENYHVSPTLKDGNAKETAAVSRHVQDRQFDLAEIQFYYQHLYNLIVKPMEVTDDLVEKIEKGIEFASEGIAKEKVVETGRKVELYTFDDELLQKFRIRTKRTKDDSANIGGHKMDDGTAPTAKLPSELFRRIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J4</accession>
    <name>A0A061D8J4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0652 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769014.1">
        <property type="nucleotide sequence ID" value="XM_012913560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J4"/>
    <dbReference type="GeneID" id="24565369"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307320"/>
    <dbReference type="OMA" id="DAFAHMF"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical E2 ubiquitin-conjugating enzyme C-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Non-canonical E2 ubiquitin-conjugating enzyme C-terminal" evidence="2">
        <location>
            <begin position="339"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="609" mass="68525" checksum="456A75D25B6D2BF4" modified="2014-09-03" version="1">MAGPNKLSSLLDSEDVGTTANGGAAAATSLESEAVKLLAKLDRVDLARAVAALGAHVDVAKVLREALPDVLEQRRAPASEEQEEYTGINLLEPTEVVPSPDVNMPVDGESLSFPEYFLQIAKFAPLRLNLGERKLMRLLDSTLHVSEYTDKIDILHEGSKTRRIVKEIKEVCAILSGLAIAHNYDDGQRLVRDREYAANAEFFRNVFEIGRRYKILNPDKIRNSYGKLIYFLMDSRKPEIQELLNFDCVAPVKTVFSLLATKKRGLEMLHDPKIKLATMEITPEGKSRSEVQREIAAKEDAVRYLTNKYARKKSGGIMGIEFSFITRPFSNSSDAADEGEMTREEVETCLYSLSDHYSHLRAFRRPCDVMIAYLRDNFNPNDPNPKYNLSISAGSDGARLSHGHAKQFTYVLQSLTLWREIAHDMFALWHYAEADLLDADNPYRLRNTGQGLNRVQYGPNVVNGMRKILRRVQQQVGAWVGSNMVHLGDHNVPNSFMFIDKYTQIPRILSPIVSCIEKIPELYASTDAMRTYIDTQFGGPKRLKMVILTDFFRHAFDGSGADNFNDAGSCIDGRLTSAWNWCSKIEKKKYFPIFLLTSFCGFDGSFGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L2</accession>
    <name>A0A061D8L2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769044.1">
        <property type="nucleotide sequence ID" value="XM_012913590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L2"/>
    <dbReference type="STRING" id="5866.A0A061D8L2"/>
    <dbReference type="GeneID" id="24565399"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307620"/>
    <dbReference type="OMA" id="CKYILLN"/>
    <dbReference type="OrthoDB" id="9985850at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="66288" checksum="A9FF05A861074521" modified="2014-09-03" version="1">MFCAVARFAKQRLTTRIYDAGTKASLKVYHLQEYARYRAGLTPSGSPGDSTAPGRGVRPDAARDIPLFRKIEDWRQIVAEVDDCVRDLSPAQLLATAIAYWRLGRVGRSEWKRLCSAAARHAYGPHANVTGISASEVALILCCYARVFNKPVHSSTSLLRWLVRDVGRLNERDVCMTLFYMRRMRAVPPVLDTSEKSSGAAMLRAIVLGLAAEGGNKLPKFSPGGLACLVSNITYIGHIPWGLMYHACNLIRKHAARLDAKTMAMHLRSLAMLRFPDKGTLKAFATRLDTTKPLPTATITCILHSYAKLRFRPRKHFGGLFEQVQKWVVVGSWFANAFRGIFLFQDHEVAQVAFALGQLGYRNEDVFESICAFSEARAEQQNPQNISMLMQSFAKVGIYRREAVDALVRQAKDTVPIHADVQAAFTLKQSVAVLDSCVVLGHFDSDVFRALLANVTRLVEDDLPDGLINQLNRIMYCLRFEHAKFVEECPPSMQTLIGLYQGHFLEAPPKEPRDALYECLEMMDVKYERNASIGPYRIDALVNGSIALELLSEAALCPLMQQPLGSVRLKTRHMEAMGYTHTTLPMKEWLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8P9</accession>
    <name>A0A061D8P9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768503.1">
        <property type="nucleotide sequence ID" value="XM_012913049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8P9"/>
    <dbReference type="GeneID" id="24564858"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302210"/>
    <dbReference type="OMA" id="NGPSCGF"/>
    <dbReference type="OrthoDB" id="435819at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="284" mass="31604" checksum="A74F42FF4C693CC0" modified="2014-09-03" version="1">MSDCIEAALPESPQDVGDLPPTTTSIDTTTNTICFNTSEMPPSHIVALDQLIQLQCNKLEKQLVALKVKRQLLHMGEGVVLSVNDLVSDVSEDSSKELLSSLEAASVVDTDIDDRFKYFRSQTVGVGHTEDISEIINAMNMRNSSSNESDDFMRRVQFTAVEEPANSRVPISRRCITLPDSHGPVTASELALLQIDMCSAGDVQLMLHIQGKCKPCAFYYNKNKGCRNGSSCVFCHHEDHCFFTLKRWKKQQRQFSQSRSLSREIMGAALNPNPKPEPQHPNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U1</accession>
    <name>A0A061D8U1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multi-pass transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768568.1">
        <property type="nucleotide sequence ID" value="XM_012913114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8U1"/>
    <dbReference type="GeneID" id="24564923"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302860"/>
    <dbReference type="OMA" id="EAWGWIC"/>
    <dbReference type="OrthoDB" id="328372at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021691">
        <property type="entry name" value="DUF3273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11677">
        <property type="entry name" value="DUF3273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34498" checksum="E74FAEBB181D50FB" modified="2014-09-03" version="1">MYFTYVVRPGEAPESRGPQFEPVWEFLMNYNLRAGFLLQLFAFIVFALGIYNGGKDPLAMLTFFRALPENFGVTPFSLTLLCHGGFIVGTLLIMSFIQMSEDDSSIKQCRGYRAGTKFLLQATSFGAVSWCLSMITFLGATYHFGAQWMEEQIGDGSNWLIFFTSRLCDAFALLLYAGGCFFLETYHSEGTNESWGWMCGSAFLMAGLCEVLALNFINTAMFAIVERLYTVSLGLALGLSAFWAFMFEPVCHRYDVKLTQSALRNEYYKSRNAMAFYGPAVVDENGEVDIAAATEQVQNSLSNQMMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8W2</accession>
    <name>A0A061D8W2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0303110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768593.1">
        <property type="nucleotide sequence ID" value="XM_012913139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8W2"/>
    <dbReference type="STRING" id="5866.A0A061D8W2"/>
    <dbReference type="GeneID" id="24564948"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303110"/>
    <dbReference type="OMA" id="FSHINSW"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="230" mass="25603" checksum="B04D15C2DAF9440A" modified="2014-09-03" version="1">MCTWGVSGAFLDFSTMARKRPILKIIILGDSGVGKTSLMNQFINKRFTNQYRATIGADFSTQEVTVDDKVVTLQIWDTAGQERFQSLGKAFYRGADCCMLVYDTTNQKTFESIESWKSEFLIQVEPKDPDSFPFALIGNKVDDVANRKVSANKATNWCKANNDIPHFETSAKTAHNVATAFLEIAKKAIARDTQDDEIYIPDTLLLDQRHVEQSGPNCQRGVASVIGCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8X6</accession>
    <name>A0A061D8X6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767515.1">
        <property type="nucleotide sequence ID" value="XM_012912061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8X6"/>
    <dbReference type="GeneID" id="24563870"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204870"/>
    <dbReference type="OMA" id="MKPAFKL"/>
    <dbReference type="OrthoDB" id="363855at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="721" mass="83845" checksum="9360737E4F963370" modified="2014-09-03" version="1">MAQFRSLQLMKCATKLLCRREGCREIATQTAAVPLVRTAPVSRSDWERSRRNTEEPYSHTGDFEAESRRVIFRNQKGFGRPHTHKTKIGTNFIAKLQSVSSNTPKEELRLLLMKISQHIDEFNEYELVDIGYYLTRVNSEDCASVVEPILHRFFSLPERHSCLNGVYIHRWVGRYELSQNARLLRTMFIYQDVTYRVWVYEVAQIVGTKHRHLLMRDVQLVIDDLSLFYDAAAQGALKKFEDVILRRAHELEIGRLPLVIHALGRSGYNTIEVARAIHNVYMKKKGHPDFYLCHLIGLLLKGYTTFHFHPGKAFLDDAWEHLKDGIKTAEFKYISWLAESFLKLRYVEHAPTVLDELLEKQHLLSHLEFTDFISGCWSIQSYILSEEFRKYVVPGTEWQLAGNGGEQSPTYETTSGTITTLYAYYKKLLRAIVDGMSSKIYNSTPPYRATQFELLTRLLVIYPNPRDFRTILPLRKFDAVYPIMQLPSEEEPHVGSVDFIFRNHTHLQASRFFGDGHNLNDALKATEESCQKYNDGNTQTVNSAESISENPLCWDVEPELKPLPNLLKQYLHSLFFRTPALAPRGIRILMQGLVRIHFEKREDCVMEPDLLPPMKTAYHSRPFSRAIIREVYRKLACYNTDDLLVTLYCMFPLRMFELDLAPTLLSQLTGMWVHQLREDALTPDQRRLIRLFYDTLKGNAADQYDRLDKHSIESIMRDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D968</accession>
    <name>A0A061D968_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNARE domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0311390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769422.1">
        <property type="nucleotide sequence ID" value="XM_012913968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D968"/>
    <dbReference type="STRING" id="5866.A0A061D968"/>
    <dbReference type="GeneID" id="24565777"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311390"/>
    <dbReference type="OMA" id="RWICFIL"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="313" mass="35019" checksum="7C0BE0BAACBCA2D8" modified="2014-09-03" version="1">MYNRTEQLQDLAEGVKRSNQYEKDCIIVVRDGGFISQTNGGDGANEEGEDDELFQQYMHKVQAMRTLIASIDEGVKEINSLIELSASAVTNQQNEEVSTKLTDIIASTNEVCTQCKAAASILELGKSEGTPTEARMRENAYNVCIKHFQAAIKRYQDAQITFKKAIKERTARQVQLIYPELDSKELDRMMDSSKGHSMLEHIARSSIIGTASLTEAVQNIQSKYNDVLALEDSVEELHQMMIELAGVVSYQGDLIDQVEYNTMRAMEYTEKANVELTKALHNQRRSNRLMVYIMLGVIAAGLVIGVPIILKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9E5</accession>
    <name>A0A061D9E5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0305200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768803.1">
        <property type="nucleotide sequence ID" value="XM_012913349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9E5"/>
    <dbReference type="GeneID" id="24565158"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305200"/>
    <dbReference type="OMA" id="PKADWIF"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="71"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="855" mass="97132" checksum="DEC30CB010777AC7" modified="2014-09-03" version="1">MKGRLVATLAAAIGCGWQTGRSIGPEAYVSQCYSGNGNVRSCRQQCGTAYLAAPSAIASRNRALPLGAGWGRTDRYCWNEDAQHVVVAAAVPPTVSADDIDVTIQSNSLHASNRKAPLIPIISGNTKGSIDVDGSFWTLEEERGILELKITLKKAEKHAGDWFGVIRNERVQQQTYEPVDHRDAGVTKVQSLEPKGVFWQRTFMTIDAHQLEEMFVRWMSREQSETTEFGKPKLPVNVAYVQESGGGKVVYQTDNLDLDEYLQVVIIPVITEENKHAGGGAQLTFVNSPTTRMISGQMGAEKAEKTVTALNTLIQTFERDVHKIEGLMKHRQQQSESFDYMGSAAYLHADNLESYAKYHEELRSLSPQKAAQYDPKRVFKDDKAGLTIDWNPTDDPPHVPNEKNEEKKKILINKLTEAIKHTKRPQPQETVKSLVNNVRQSLALSDVEYDQLMQKADERINRENALIAEKQRIFSQMKSVPALMEAQPTIEEIVAEVSQPKSKDTFDIAMAHPERSMLAKKYATLSSVQKEQLRSRWKTNEKRLKLLITELLEAPPEKCSTLCNTYTDLLISEDYPTLMRSYLCFHEVKDKHEKERLAFLNQFVLSLYKDQKIYLLHDEKIQLQKIKQIILWARNEFQNLNDLVMQNKQQYDTNFMCYLNLAISKEVERIREEHGDGSLDSGAANPEAQPWLCVLTIIQRAVNSIAKADMAEDLNFITTIVSFDDPQVRSYMLEFILATMPRSDWKGFKDLIMSASESLIRKPADERDDLEHTEPHFVEAIMQLREEVEKMIPDWIIDELLSEDDRNFMIQNNRQKIPLLQLELEPKQHVGAATHLPDAGKTPAEKTPVLPLKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9E7</accession>
    <name>A0A061D9E7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0106340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766511.1">
        <property type="nucleotide sequence ID" value="XM_012911057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9E7"/>
    <dbReference type="STRING" id="5866.A0A061D9E7"/>
    <dbReference type="GeneID" id="24562866"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106340"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="24787" checksum="9325A55C22AD7189" modified="2014-09-03" version="1">MTDAKKKTIKKRTKTRSKKVVLVKPKEEPKTDNYSFVNLRRVSVPANRLTPLRNNWEAIVRTVVEHLKLQIRMCTKTKVVEVRPASESTDLSLLQKAQDYLRAFMLGFELKDAEALIRLEDIFVESFEVKDVKRLSGDHLSRCIGRISGKDGKTKHAIENMTRTRVVLANDRIHIMGSFNSIKMARHSICSLILGNQPGKVYNNLCNVSKRLREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L6</accession>
    <name>A0A061D9L6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769414.1">
        <property type="nucleotide sequence ID" value="XM_012913960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L6"/>
    <dbReference type="GeneID" id="24565769"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311310"/>
    <dbReference type="OMA" id="NWAIEET"/>
    <dbReference type="OrthoDB" id="430536at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="15274" checksum="04668B0AA26C1278" modified="2014-09-03" version="1">MLTPYLTRAPQRFALQARRFGAVYAGRYVTSDQLEKKDPNWAIEETNFCLGKISELRFKDTDDLARRTLQIMDSQLSKMHTRLRDGTCVPYMALSLHQVVDRPCPNHVFIEQPLLKWTWDEAYDDAYENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9M0</accession>
    <name>A0A061D9M0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767805.1">
        <property type="nucleotide sequence ID" value="XM_012912351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9M0"/>
    <dbReference type="GeneID" id="24564160"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207740"/>
    <dbReference type="OMA" id="SAFQMYH"/>
    <dbReference type="OrthoDB" id="365893at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040346">
        <property type="entry name" value="GEX1/Brambleberry"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538">
        <property type="entry name" value="PROTEIN GAMETE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538:SF2">
        <property type="entry name" value="PROTEIN GAMETE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596120" evidence="1">
        <location>
            <begin position="21"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="295" mass="33054" checksum="9F42051D23079CA8" modified="2014-09-03" version="1">MRGINYRILALIFPLSLRLALPSDYKTWYGSAKNSFSRGKSTYDELVKSAQNSEDECVILHSTDNRLSTTQGAGRGTGTESGSFPCLDHLQHKDNRSNFDINFNIGDVAGGSREQRLVAEGGCWQFVLNQVSALDIDRCDVKGEVSRSLIALAKTKCHLIRSGRTFPLAEHGCLLNPDVLDDNALGLLGDQYTSNPCRSVYNSGECEKLKEDIVAQCTNPRVMTEAAFQMYHADLNHIDDICFYLQSNEWNRRTESNINRLGESAINLLNTQQNMEMFLAGMQKQQEESLRKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U0</accession>
    <name>A0A061D9U0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30S ribosomal protein S15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0306410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768923.1">
        <property type="nucleotide sequence ID" value="XM_012913469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9U0"/>
    <dbReference type="STRING" id="5866.A0A061D9U0"/>
    <dbReference type="GeneID" id="24565278"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306410"/>
    <dbReference type="OMA" id="EPMKRHE"/>
    <dbReference type="OrthoDB" id="364880at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00677">
        <property type="entry name" value="S15_NS1_EPRS_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600726" evidence="5">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="299" mass="35048" checksum="A489C49FE37CEA9E" modified="2014-09-03" version="1">MRWFPLCLKVALVYCVVGAVEGYKIRFGRERSRILKLRKRKSAFVDRLNLITRTRGIGIFTLRATADDSAAIANPGEESQAAESFEEFLPKKKKKRQPKNPIVEKDLERYEPIFRKIPALRQVQKEVERDQRPGALNPLGYAAHFVPEGDWSFHPNLIRVRGKYFSKLYEKELSEPFKMHDRDSGSSQVQIAALTAKLDYLARHVRNNHKDVQARLQVIKLGHRRRRLLGYLYRTNRSAFDTLIKTFNIDFDDSPYCYKKLVPSYSHMHHRKTKRYTSAKEQRTATRQRVVSTMNTEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9W3</accession>
    <name>A0A061D9W3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0314030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769687.1">
        <property type="nucleotide sequence ID" value="XM_012914233.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566042"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0314030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0314030"/>
    <dbReference type="OrthoDB" id="366456at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1438"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="961"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1500" mass="167242" checksum="62A765CC3546A725" modified="2014-09-03" version="1">MKELIKNIKQRVSAIMKQLTKINSDLLQHIDTLQDWITKADNVIKESLKKVEEILKEVKDSNSRTENNRRKIESAVEYIQSQVKLLFEAGELARKEAASLVGTAKEKVTLLENAVKGDLATLKNEINNGMKEYVSRYITEIHNSVKEIKGGDASGLTELVGRVKGYVKLFTKGKLAFNSVLQRWIGEIVDKEPVSGWLDKYVEEMNESSIQFKDVYIAIQQGSDHRLLAAFKNKLIEELHAKVNEAFNSFYAVDEKGSIGSHVGAAKGACLQFAKKLGDELEDGMIGTFVEDIADAISLELTTQKNSNPYLQLAVDGVLYQLLAAARHTAAAVESFTWDDSASDPDVMTVDSALGVAIHLDTGLSKALASVTPGSDGDLAKAYIYKPFHSLKQPIELDVNIQKTIYDMLEKQLPEDQEAADNLQAYVTLDNLADSFKGIATRFGTKPSKRKQLEDAINNIEAEVTIALAGIETFNDQALRHFIEVSNKLNEMCYAIENAAGEPNGLKSTLKTFKETYFAKYDKDTQEGKAGIDKIKQDLSDVQNALKTGPVDKTNDLLQYAMKAENHFAKLIKDQIHQDIKTAETALTTHARRRYVDSIKWLLGQFVLKVETEFSQLLLQIEHDKHIGLKGFMEAFNGNDSGDNVNRLLSNSDIPTLCRSVETFFAPVKSYIDSEITRLDGEELKKHPSLPRSQDPYTSKLTKLYAALSGLISHVYTSNKYDRDLPTKLDDLTAAVADLTTDGFPNPVTAMLHGVSGGCRELVGALGKVYISRYDGANVRWEHDEKAVNNCAKAFLTIVPAYFHGLHHLFYKGATEWKEYKVAGNAKSDRKADELKKYLQEEGYDIDQLKDQTGKEVALRLSRGFARYQSFNENPENLGTYKEYLAHYKKHEGLMSRLFYYLDAYNHVGHLVVHPRPRHPSSVFDILLWLNGLPYNPVYHALSYDGFSGLFEREEKKGDATADDDGPTFEGEEADTLPAHPKDITAASLADKLTEVTTYAEDVLLSILGYGHNDGIYACDFYTNAGKLAYPSSAAKCLDVLVELLYRLFHQLRFLYEQCSNSTQYSGWAECWYGQGVGGSSWKCNEKQCADQNCRQIADQIANQKCKQHPKCGVKSPLQSFLEDGLPGFLPHPYNKADCKLSCSAPNHFGKPCKTPMGFADISITASHTSKGSRLYKVLKEFCGTPSSPLTVVCSSLVCVLGRPPQTLGDMFAFYHLFITTWNDGGKKHKKEAFDEAVTKANLQRPYDELNVASIFSTTHSGKSKTHTSGDLISLVCSSKTAATCGQYLSPLSNDISATFSLKHADKYVSWMVYLTETFYSLLKKMYDECNSKCGGATPKCRVAKCPKKCTANEKSPGSTHHSLCDSIINCPSTSSVLCTYGFTLVDRKKLSGTNDVDYKRTCNDLCNALKKVLDGESVLMQLFHSIDKFIFTIRAPFIWLNVALWSLSFLYLIHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Z6</accession>
    <name>A0A061D9Z6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768973.1">
        <property type="nucleotide sequence ID" value="XM_012913519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Z6"/>
    <dbReference type="GeneID" id="24565328"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306910"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="334" mass="36738" checksum="A877436334FE3E3C" modified="2014-09-03" version="1">MLYNSLTDIPRNLKEGIDWLMAVKGSCDENNWKAMVGAVHHLFSKHSARYQQLPALEKIKSVAKEFLQKPGLRDNVVAKEVLELFDTLDSAAKTGEKASPYKYYDENGHAIRVKGAKPEYIEQTLRKVVDGCEKFLEDIKRPETYRSAYSSEATWEASCSEKPEDCAVVLVGIAPMLYAGLQSLSDVAEQDNGWFISVTTYKNPGEVLIPLGYYSSECRADLNGAEIFRIFNSLDEDLFHKTYALAGFDTFYGSDMVQNLPVEQSIKPVQLVEEAVVAQTFVGSAKAGKSAKGTKLGKSGKHGKPEKSGKHGKSGKSGKHGKSEKSGKHSKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Z7</accession>
    <name>A0A061D9Z7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767920.1">
        <property type="nucleotide sequence ID" value="XM_012912466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Z7"/>
    <dbReference type="GeneID" id="24564275"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208880"/>
    <dbReference type="OrthoDB" id="10607090at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="270" mass="29631" checksum="F07591B405DE3836" modified="2014-09-03" version="1">MASVKRGSWAGSSLFCRAIGWTSLLLALISFSSVSNCVTVRRSILKKTVAHTTGHTSIGDMPSTDTYPVGSLPEAKLEEQAAANTINKYKANAARDEQDDNDDEEQQANDDSSEVPRLYEVSSSEGEGEGDELSEPDATADNALDGDNDNDNANDAADDGDDGKDGDDENVDSADVPKSYLEQDSQRILSLPNHPNIHLLGREYEPPSKHPKLQKVRRVVRGMSRLGAEYAQKGLRTARDVYRQHAPIIADKAKKVAKRFKNFVTKRNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA19</accession>
    <name>A0A061DA19_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0312710</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769554.1">
        <property type="nucleotide sequence ID" value="XM_012914100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA19"/>
    <dbReference type="STRING" id="5866.A0A061DA19"/>
    <dbReference type="GeneID" id="24565909"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312710"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="69"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="256"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="481"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR97368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="521" mass="58837" checksum="B69C1A56314AE100" modified="2014-09-03" version="1">MGSTKVTSRDASAPEDSEAASPSESTQTPRKHDYFTDVLFSDLELSEPLLKGLNELSFERTTEIQAKCIPHLLQGKDVLGKAHTGSGKTLAFLVPLAEVLFQVKFLPRNGTGGLIISPTRELSEQIFSVANDVCKYLPQTIGIVMGGTNRKNEAERLTRGVNILIATPGRLLDHMQNTNGFLYKNLLVFVIDEADRILEIGFEEEMNQIIKLLPKKRQTCLFSATHTSKVEDMVRLSLTNPVFVQACSKDVATVATLEQGYVVCEAENRFMLLFSFLKRHLDKKIMVFFSSGNSVKFHDALLNYIDIPAKSIYGKKQQNKRSGAYFSFCGAKSGILLCTDVAARGWDIPKVDWIVQYDPPADPRDYIHRVGRTARGADGEGKAIMFLMPEELGFLHYLKELKVPLSKYEFELSKIANVQVQLEKLVEKNFYLNRASREAYRSYLHAYLSHSLKDIFNVHSLDLVRVARSFGFSNPPKVDLNIKHADRKKRPREHTESEARREQPSANLLSKKKADKRQFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA42</accession>
    <name>A0A061DA42_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHORT-CHAIN DEHYDROGENASES/REDUCTASE FAMILY MEMBER protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768993.1">
        <property type="nucleotide sequence ID" value="XM_012913539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA42"/>
    <dbReference type="STRING" id="5866.A0A061DA42"/>
    <dbReference type="GeneID" id="24565348"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307110"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="651" mass="73297" checksum="7395C3C885CBFF90" modified="2014-09-03" version="1">MRISLSRLADARALTEHCGWKLQVALCVDRQPTQFAEFAADRAFREFAEAWRRSTLTQLNVPKLSTIESKITHKITPSKERKPASTNTETEAAVEVTEELDELLAREIAFRPTRRRTQKGQLETKQVEKVNVDGDLRNVERLAQHWLFLALKHRLHGWMLPTADLYHGDGLRQTLQRLCAEQLGESYTPYFIGYAPFFHRTLPVPQVGVESEIKGNKIFYFRARHVPGTALDIRPQTTDIVDHAWHYRSCNMANSSKSKTNSEAPRVVACAADPCYRALIYVLAFVLAHFAVLYKTRFDVNAIARRSVLVNLLHMTESSWAVGLFVLQAGLGFLSLCVYASRFVAAGSPLPFILHEHTDLVGHTAVVTGGTSGVGRETALQLLLWRCKVVIIGRDKTKGANAVEYLRQKAKVGFEMIQYVEMDLNDKKSIATAAAEILRTNASIDFLINNAGVAQEATMNAHKMESMFAANFLGHFYFTKLLMGALKRDKARIINVSSLAHYCYNPNDDPLLKGGHTMQLPRNANAQTYYARSKLFNIWHAQALQRRFDKLEKEHRGVVCFSAAPGIVATPLLESYTRRILAPVLRAVVWCFTKTPRDGANTILYLCSAPLEELTPGGYYYECKLGYVSKHAQDAPKQEALYELAEKMLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA3</accession>
    <name>A0A061DAA3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769664.1">
        <property type="nucleotide sequence ID" value="XM_012914210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA3"/>
    <dbReference type="GeneID" id="24566019"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313800"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="8122" checksum="CB9EA7037150A4AA" modified="2014-09-03" version="1">MQKGILRTRKSRMLRPTGKRKMHRSSKMMATMMATMTAAMVLGSGEKGVEASALGSPVEGCTSEGSDKRGSLTDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD1</accession>
    <name>A0A061DAD1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766876.1">
        <property type="nucleotide sequence ID" value="XM_012911422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD1"/>
    <dbReference type="GeneID" id="24563231"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109880"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28352" checksum="32064C6E38CE6E3C" modified="2014-09-03" version="1">MVYNSLTDVPHNLREGIDWLIALKGTDGEKNLAAMGSALYDLLADKPVGKKVLPALEQIKPITKQFLEKPGLKGHWSVKRLLGRFSEPMNKTIFMWFKHQWGYYASDYENIIQTEGVKLKDMVENLGKVVHGTEKFLDDIKNPDEYKSAYSSEATWDASCAKNPEACAMVLVGIAPMLYAGLLCLWNASDDAAEKWLVINANERFEKLLKALDYKEPDCKDNLSAAAVRKALCSLDNSVDILYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAU1</accession>
    <name>A0A061DAU1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769298.1">
        <property type="nucleotide sequence ID" value="XM_012913844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAU1"/>
    <dbReference type="GeneID" id="24565653"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310150"/>
    <dbReference type="OMA" id="RIRTCDI"/>
    <dbReference type="OrthoDB" id="363445at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="129" mass="14940" checksum="ABEE8714D3755944" modified="2014-09-03" version="1">MEDWQKWTRRTTNAEAPKKPPQYLFFPNRTAGQTYFITVLTGIAILSLSFGLLKSAEGSQDKIARTIQNDTRIRTCDISNEHAIFLKHREENQIRRQRRYLNFNPKPAAAILISDPELRNNEKSGHLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAX7</accession>
    <name>A0A061DAX7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Rad2 endonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0200270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767056.1">
        <property type="nucleotide sequence ID" value="XM_012911602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAX7"/>
    <dbReference type="STRING" id="5866.A0A061DAX7"/>
    <dbReference type="GeneID" id="24563411"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200270"/>
    <dbReference type="OMA" id="KESHVNY"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="749"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="541"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1057" mass="117647" checksum="440EDCA050B87331" modified="2014-09-03" version="1">MGIKGLWDAVAAAGVSSRVEMLRGKKVAIDASFWIGHCIASETAERRGQDVYGVFFLRICYLLEKRIYPIFVFDGRTPGAKRRTLLLRNMSRAQRTRNLRLLAFKALAVQMKHLAKSGNDRVFKPSSFMKRKKGFSSKELRAIAADLEVVAEPSASEPVPALAIEDVVAESSPKEDKLFSSDDEFEDTPALDIAPIADVPAEGGPRRIDILTMPQSYKSLKMRARSGANVDLSSASGGNELDSSYFDVSSGSRSHGHGVGRSKRTIELPLDCSINPESYEQLPSDVRYQIMNQIKDAWMYDDRVNLLRHKSALNEFSNLQVESYLRDVEINREIEKIKRSLIRETMPSGALKSDCDVNFDQAKVEALEDEIHDYNVAEGKSRRKRRFLNDLSENMQPDLYNFAVAPNVKTEPVEVDDSLFLRDSEIFGDLVKSESEDEFEVTDERFPRKPVDDFEVLDETPAVLWSPKSIAGAIQQSSEIPGAASAIMDSCGVASEPSAIPSEDPTKDEIPHKCANGLLSDTGIETYPLYNDIVHEGTCMGTVASNPDSDEEQHNSSSHSPGYLSEASGDSDAGSKSLSDIGDDMSELGSDEALEISSSSESCDEPVPSSQKESIGSPEFDDEGWNIDDDEDVVSVATEGDTGIPPDDDEDVSPANVGSDAQDAPESAEQCHKESEDSSRISAEAANEDSAAADDATAASESIVASGPAPMYNNEWQYRDFLRMEKLFSHAERSTYRMDEWDKVPELLDLFGLPFLVAPSEAEAQCAHLNKIGLCFGVISDDSDTLAFGAKRVFKRFYSGQIFESYVSERVVRELGLGQEQIALLAIICGCDYTPGVRGIGVVNALEVIKAFPTFDELYEFRRWATSDVDLATVTDDPCPIKRAYKESHVNYRLHWSFSSDFPNREAYNLFLSPVVSSTFDPRWRAPRFEEVKRFMAKHSSLPESEVDTCLSKLRVKDNFEGYILEDFVPEIHAGSHRKGHRSLKSNRKILQERLSSFREFLSERERRKSKKARARQRPLRASGNSPPRVAFIRSKRMLASIESLKQRAQEERVTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAY2</accession>
    <name>A0A061DAY2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein Cox11 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0403040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770002.1">
        <property type="nucleotide sequence ID" value="XM_012914548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAY2"/>
    <dbReference type="STRING" id="5866.A0A061DAY2"/>
    <dbReference type="GeneID" id="24566357"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403040"/>
    <dbReference type="OMA" id="THSHLKW"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="292" mass="33112" checksum="6C2CF1310F060910" modified="2014-09-03" version="1">MAGHFGQSSVVKTGLMATYFTLHRPLFHVGARIRCHSSLAAINRWFDTAPSRRFSSRVVPPSQSHTPKATQSRDGREDKFMYLQTRFSRTPVVNPLKEADSIGTTLLGVFIALFGITFACVPLYEFFCQQSGYMGTTKRVKTYKPPPDDRGGRMFEIDFVTHSHLKWDFKPAQRSVVIGAGETTLAFYTVKNLTDKPVIGVAAYHVIPDEAGGFFNKIQCFCFEEQMLHPGEEVDLPVLFFLDPDILKDKHGVDKITLTYTFFEANSEIPPEYTTLLKRMFDPSIWARHILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ8</accession>
    <name>A0A061DAZ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767081.1">
        <property type="nucleotide sequence ID" value="XM_012911627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAZ8"/>
    <dbReference type="GeneID" id="24563436"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200520"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="185" mass="20542" checksum="4C14D29010D465EA" modified="2014-09-03" version="1">MVTIWNGQECTKCGNKCRRAQECNCCPWCCYECNKAGVENCDVCWYHIWKRKGGSMRYDCRNFGCETKCAGKEHTCQCTCCRAKCQVPGACSPPAPRPPVPSPGAERQTSERRLTDSSTEESSARSSDAETSTPPPPDPQAIAAVIVAIIVAIVLLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB36</accession>
    <name>A0A061DB36_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0300340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768315.1">
        <property type="nucleotide sequence ID" value="XM_012912861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB36"/>
    <dbReference type="STRING" id="5866.A0A061DB36"/>
    <dbReference type="GeneID" id="24564670"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300340"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="261"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="488" mass="54538" checksum="FA3AF97AE8105B28" modified="2014-09-03" version="1">MIPEISVIRQVAENIEVPYKVTHLLDADAEVRLDQIVGQLSLPIEYLKDVAQSFYGELVNGLKAHRRHRNLWLPNECSFKMLDSHITTVPTGDETGCYYAIDFGGSNLRSVRINVKGKGTMERMQSTFSLRHATALRPKGLLDRTATATELFDHFAKSIGNLMEESGDAKDSDKIYPVGFTFSFPCTMLTKRNAILLDWTKGFETGRDTNEQVEGRDIGMLMDEAFKRNKVNGRVSIILNDTVGTLMSVAYQKPQGYPECRIGLILGTGFNVCYVEHEYLRYGYVGKVINIECGNFDKELPITPVDYEIDWYTSNSGRGKMEKLIAGAYLGEIIRRNMIIYLSERATAQMWKVGTFTAVDAADILNDKSDDHAKAREIAKRCWGADFDEKSLKGLRRICEAVFDRSAGLAAAAIVATARRTLAHATSKITCAVDGSLYVKNEWYRERMLYYMEKVSRADLVGSVIMYACDDGSGKGAAIAAAMIKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB87</accession>
    <name>A0A061DB87_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770142.1">
        <property type="nucleotide sequence ID" value="XM_012914688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB87"/>
    <dbReference type="GeneID" id="24566497"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404440"/>
    <dbReference type="OrthoDB" id="10324741at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="27910" checksum="C68AB0E0EAEA8C43" modified="2014-09-03" version="1">MVYKSLTEAPHNLKEGIDWLIAVKGDDAANNLMAIGTAVHKFLADKPVGFAEVPALENVKRISKEFLGKPELKDQWPVNFMLRKFNQPMDKNPNIFVKIFGDVEESDYKNVIQDKSVSAETIAKDIGDVVNCCEQFLEKVKIPDQYKSAYSSEATWDASCAKDPESCAIILVGIAPMLYAGLNSLMASCIAAFFRGLNSKAHRPTQQLLQALGCIEPECRAGISVPNIIMALGGMDKSVMTTIYDLSGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB3</accession>
    <name>A0A061DBB3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">-Structural maintenance of chromosomes protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0402960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769994.1">
        <property type="nucleotide sequence ID" value="XM_012914540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB3"/>
    <dbReference type="STRING" id="5866.A0A061DBB3"/>
    <dbReference type="GeneID" id="24566349"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402960"/>
    <dbReference type="OMA" id="FMCHRSL"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="211"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="390"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="750"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="892"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125507" checksum="405589FF35B55DBA" modified="2014-09-03" version="1">MDAREERAAEGATPELGDSTSATLPEAFENSAGKVVKVQLINFLNHANLLIHCSPYLNMIFGMNGLTQRTEGKSAIVQGMALCFGGYGHSAGRDTALLHYIKDYHLRDGPSYARVEVTLSNQGDGAYKPELYGDAIVLARVIHKNHSSFYMGGTLVKKATVNKKEVDRYLRHIKMSIGNPTTYMDQESSKSFFFHSNPSSFYRYYSAAAGLVEMEQNLSTEKRNLEECKAELKVRKRVLHPDREKLRDLSKQISLFEEKLTEWKSAKEMYRLSQYRAYKERYEALKETYDRFHQTDPKDEIVKLQNSIELFSAEHEEVKFDMQTQTSKTYHHKDSITTITDQIAVLNDSIGDMQSRISAKKACISQVETAMANLDGELSAVAAEPADADKKCLERELDVCRKEYEDVTEQQESTSSAMADIESAIEDIETQIQKAKIDLDEQRRENASLEFSTVPSVRSDPLRRALYRYDVNAVREDIQRMRDQGVFIYMPIGPIGDYLVVTRDAPTWKVLAVVEHHLRSMVHTWVVASEQDRRALESLLIKHGCSRSQSKIIKSNVFMRPDLVERMQRKLSTMSHRQSIYSYLAVKEIPPLLLYVLDDVCGIGRAVICIDDEQMYEVLSEGGDKVNVVYSLTRLNSGRRLNGSLYLSPCYEKHPFSYEYGNEGDYSWEREERKDSGTQRESSLKSLLSSLSKELSECNSRLNAHRSKLDEIKAEQTRVIRKRTRLETDLETELDSLQSTSHSSRYNKCCEALEEIRSDYRRQLKALGAELATLEAELSAMESNKATKEEELKVANSDLKATLKTVSSLKVDMQKIQQRINTQKTQIKALQKNMEDYNFKLDGYVNDLKEAEKKLESHKAELEAEGIDYSAELPTKSPEDYLQILNLSNDVLKRIVDDSRNIEAHLQSLREKHAAAEQSLRDKELRLTETTENYSLQKKNYVKRCRRFEECRARIEHKAKKAFRQTLDAVTGYDGNLVFNDVNRTLDIQIHNKQQSYSRAHLATDLKTLSGGEQSAIQLSMLQSLATISFSPIHMFDEVDVYMDESTRIKNIESLVQFAANNKNRQIFLVTPHSELAKHIKDKYPDISKIFNVARDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB5</accession>
    <name>A0A061DBB5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FERREDOXIN/FERREDOXIN--NADP REDUCTASE-RELATED, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0301040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768385.1">
        <property type="nucleotide sequence ID" value="XM_012912931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB5"/>
    <dbReference type="STRING" id="5866.A0A061DBB5"/>
    <dbReference type="GeneID" id="24564740"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301040"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="402" mass="44860" checksum="69575377DF0EA46D" modified="2014-09-03" version="1">MHPRIAIVGAGPCGLYLARNLRGHVLPGARVDLFDRLPQALGLLRFGVAPDSLSIRRSATPLLANTKERFFFNVRVGTDLGIDELMRYYHVCLLSCGAESPRPLSIPGDSCEGVFDSLDIIRSYNSHPDAPECVRSYFLRLAKLGRRVTVSIIGNGNVSLDIARILLTPATFLERTEIDKTFLHNLRSVDIAAVTIIGRRGIFQSSFTNPELRKITETNYFSPITQNHSVERSLVYKPPVLDRRMRRRLEFFNGIAHDNFEAVHTPRTLHFDFFKTVNSIEGGKDSAISAIVLDENRLDDRLNAHITGKLTSLKSDMLIKCIGFQRSEESDVLLRSVDLKRIFGCGWFATNGQGDLSATLAATLQLSRIIASLNFDFPVEADIQDLFVRDSRFSHVRVGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBC8</accession>
    <name>A0A061DBC8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="15">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0403160</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Peptidyl-prolyl cis/trans isomerase (PPIase) that acts as a key virulence factor by promoting host leukocyte transformation. Binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins. Promotes host leukocyte transformation by binding to phosphorylated host FBXW7, disrupting dimerization and promoting FBXW7 autoubiquitination and subsequent degradation. Degradation of host FBXW7, leads to stabilization of JUN, which promotes cell transformation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with host FBXW7; leading to FBXW7 autoubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="15"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770014.1">
        <property type="nucleotide sequence ID" value="XM_012914560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBC8"/>
    <dbReference type="STRING" id="5866.A0A061DBC8"/>
    <dbReference type="GeneID" id="24566369"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403160"/>
    <dbReference type="OMA" id="CTSAQNG"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="6" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="11 14 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="PpiC" evidence="17">
        <location>
            <begin position="63"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR97828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="178" mass="20353" checksum="B9ADC2A65616B29C" modified="2014-09-03" version="1">MRNFLRSLPHVWSQTAGLNYLLVAVRYMSNRRRRLLNGTDYLKSKSGYAGRVTMPNMMREMVPTKVRCAHILLKHKGSRNPINRNTNQRITRTKEEAIAEMTRHREEIMAAEIRDREFRKKATNISECTSAQNGGDLGFFTRNEMQGPFSTAAFLLAVGEVSGLVHTESGIHLIYRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBI2</accession>
    <name>A0A061DBI2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770252.1">
        <property type="nucleotide sequence ID" value="XM_012914798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBI2"/>
    <dbReference type="GeneID" id="24566607"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405500"/>
    <dbReference type="OrthoDB" id="364284at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="147" mass="16647" checksum="E71FF8FAFE936757" modified="2014-09-03" version="1">MDPNGQRNVSGHDNMLGQDFQQMQHGCNTMPMDMTPNHAGNMTYMMPPIPVEHTNPMYGESMGMYYQPPAYPMYDNGAAYNVNAMPYMHPQMQLMPQYDHYQPRGMAPPAAAFTPRNNCQEVNPGRVPPLHMGGRAVYRKQKGFLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ4</accession>
    <name>A0A061DBJ4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770109.1">
        <property type="nucleotide sequence ID" value="XM_012914655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBJ4"/>
    <dbReference type="GeneID" id="24566464"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404110"/>
    <dbReference type="OMA" id="EANCVII"/>
    <dbReference type="OrthoDB" id="360784at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="74053" checksum="E576AF1C8A1204BD" modified="2014-09-03" version="1">MADENVEKTEQTGQNNKEGTCMSVLGRSFLQAVCATVPFKNALFGGYCQISEQNDDVMEDVEYVSADEMPAVREPREGEAVKRDRETSELTNNYEVKREEPEAINNEPVVDQQVEPIVIDLARKVVNIDVAAKGKYNFSKSRTITLDEYPRDERLTERAVEIFVENSVSYAKTAIDDSKVILADKIISQMIRKVHEIYGDPDAYDLETLHPLVNVVERLPKETPTTIRDAIEAVANDKSFINNVAEKLLVLDIFSKFNMVYMKTHIINYKQHFISKLWPSAIETAGYELKSPRCPSILTTERLPYEADYASLLATENLQTCREVPQVRRSPPAKQVVLIADEKTKTKGNDGETKPKQAKVSKYMSYASRFMSRKNTMFGQHFGKNKVKTADGWIKSAYGSLETFYRFEQNGSVSVKVRGKLATDLLRVLCVINETDLSSVWVPFLKEATEVHVYSKTTKLYSQTYEYPVIGAKQTTVFGLAVNALDEFGCFILACRAPPESQQDVEQLENILKDGGIDDTSPFVSCKDGVCQLMGVDIKPMPPKTRQRSGDLCFLVYPMKNHTLVELNANIMPEVRLVPARVITYIIKKVVINIFQKIAQISKNFHNTPFAARIEQNKEFYDWVAKLHDKYVGRGDRQNCNVSICTYDTNVNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBN1</accession>
    <name>A0A061DBN1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770154.1">
        <property type="nucleotide sequence ID" value="XM_012914700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBN1"/>
    <dbReference type="GeneID" id="24566509"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404550"/>
    <dbReference type="OMA" id="IRIDITC"/>
    <dbReference type="OrthoDB" id="366407at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="570" mass="62827" checksum="CDBF9FF3F487BE39" modified="2014-09-03" version="1">MSVIGFKLKMSWLLKHCISASVLAGCMVSGVILDIESDVLPDGVEVFYGTFPNGGIYRFIRGTDEMITESTYSGSSMYCFLSRMEHLAYSHVEDFRRGEEHYVRYYIGRKLNGRVIIRSNNEKRLGWAVNPQTTSELETFISGWVLLPVDATGELPQHPLIHTTRAHSTNGSVTYRVKTQFPTNTGLTVKIRTRIYKLGEIHVSHINDISLGCTSIFRIACDYFKMYMDDEYYHIVTDTTDIQVDVTDMLERNVSDACITSPTSSGPLGYKGSEGGAPSFDLTSPEVSDANGLIEVNEATPGAAHMATRSIYVLVPTQLGYEPRFEEYATYDPSSNTVTYDIDFLTTHYAPQCEGKRRTTIWLRAVRAVVRSDSTCVFFCAASTDAPIDSRDDAQSTESVSTSTDDANDLVDMDNFIEQMTTPGMDTISDLLNASDVVNDDVDAGGAINHLYSIIDVLTTKLDEVVPNWMDDVAAMDSSEVEDSCVESGASTSFMPHTQISEATDSQDAATSQNATMEHNVTGVGDQSSELAGAISSGGNAWLDYESLLADICSYPEFDVHEPSRKRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBN5</accession>
    <name>A0A061DBN5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767346.1">
        <property type="nucleotide sequence ID" value="XM_012911892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBN5"/>
    <dbReference type="GeneID" id="24563701"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="11283" checksum="374474DA7A1A90E1" modified="2014-09-03" version="1">MVNTIIFYQYNVVEVTTCRNKVEDLTVWMLLKTIGTFKTRAPQPEPAARLYLGGVTATESPKSHLIRTFEAPLMSHISYGCLCVLFANQFAEPNNFKKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR4</accession>
    <name>A0A061DBR4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769588.1">
        <property type="nucleotide sequence ID" value="XM_012914134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR4"/>
    <dbReference type="GeneID" id="24565943"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313050"/>
    <dbReference type="OMA" id="FWEECLT"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="589" mass="64941" checksum="816941879CA94677" modified="2014-09-03" version="1">MAPSDAASPVSDSDERYMSPWSDGFKASSSGAVPTFNLHTTSISTLYQSDSEFTTHSPCGSFSSEACSRPTAHESFENEAVLSQGSSTKRGGATIDARLLRVEHGLRANGALNGVLRELSSIGADYASRLQALADGMEIGFEGESRGMSAAVGALRAYIVSLAENQREFADAVAHECTVPNDTPDACAGIRGDLERARSKYDAAEASRTSLVAGVENLYLQTKSAVSMCSEAFHEPPSVKTRLHAGLISVFLKFMRSNGELSQSQAVNARVELDEETARLSESLRSIDADRVCGLRDGISKLVVYETARLRNLQYDVCHLVTALNDVDPEREWSEFEATGHQDMVEVPSESSRSPTHYATYLKAEIPEVFRNYAVSQLALSAPKERVLQRIERTLAKYIDAVWDDKADSVQMADFVGEMQSSLVRQVFCNLVTTRSLQCNRLPSMAALKLFSRLVGALLAFSRKQGDAWTGYAILKLADFVHVIEQPAEGQPRRTSLRWLIYSHEYWSRIPFWEECLLIAIAQDFAALFEDVRPDTVLKPYTSELLRFRHWMAAFGISSAESCALIERVCGRLGLPGSYTQCLQEPKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBX8</accession>
    <name>A0A061DBX8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769673.1">
        <property type="nucleotide sequence ID" value="XM_012914219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBX8"/>
    <dbReference type="GeneID" id="24566028"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313890"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="157" mass="14648" checksum="CA8974BE88D8A870" modified="2014-09-03" version="1">MRLRGLGAAVVEGSGSGSGACCSWLRGLGAAVVEGSGSGSGACCSWLRGLGAAVVVLQLVEGSGAAVVVLQLAAGTGSGSGTCSSWLRGQGAAVVVLQLAEGTGSGSGSVAVEGTGSGSGCVAVGECVARLRGLGAAVVEWTGSGSGSVAVGECFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC49</accession>
    <name>A0A061DC49_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768700.1">
        <property type="nucleotide sequence ID" value="XM_012913246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC49"/>
    <dbReference type="GeneID" id="24565055"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304180"/>
    <dbReference type="OMA" id="HERECED"/>
    <dbReference type="OrthoDB" id="365049at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="287" mass="32635" checksum="722963F95CE8D2F5" modified="2014-09-03" version="1">MVYNSLVTAPSDMKEAIDWMAAVKATGGAHSLAEAVAHLFHVGSKGGYDLGLIEEVRHHVKLFLQKPGLKEHAASRQIIKKIVETCIKFIRTTDDDNAEEEKAKSKRRLRRKHRKKSRKKQSEADEKLAEDHKKYEVAPDKPPVYIISSKLTEDEIKKGVQDSLEKFDTLLKKIRKGQTYVPTYSTAAEWERCCAPDPLICAQIFVGIAPLLYATSRMLRYVTTFTSGIYKIADESKKLGQFFRLAGYNVESDINARKTVDIFRFNVNFITEDFAMRLNELSGFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC61</accession>
    <name>A0A061DC61_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767536.1">
        <property type="nucleotide sequence ID" value="XM_012912082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC61"/>
    <dbReference type="STRING" id="5866.A0A061DC61"/>
    <dbReference type="GeneID" id="24563891"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205080"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="261" mass="29451" checksum="EBDE716940E19767" modified="2014-09-03" version="1">MKPPQSDDLTKLLKVLTTNSIRSVQLDEGLNVDGYLWNFTVSQLQRADYNGNLLEDLDAWPLYRERARLEASTGTPIRDVFIYNVLRDMPRIVFCRNKKVPEIRHQLVLEKTRTTSLHMKSVDSASRVSNKEQVVIGILGVDRKGDISIKGTLSQLRLVITPDTSIEHGIYCHSCTVIVHGIMDPYKEAIRCTEIKHPPFAVETEIPDFFGGNVSLKEQSAFESRMTILKEGGGSERWVVMADLHLDVKGTLDSLEILLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC99</accession>
    <name>A0A061DC99_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769863.1">
        <property type="nucleotide sequence ID" value="XM_012914409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC99"/>
    <dbReference type="GeneID" id="24566218"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401690"/>
    <dbReference type="OMA" id="NEHFRIV"/>
    <dbReference type="OrthoDB" id="366070at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596208" evidence="1">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="280" mass="32037" checksum="374D9220863082D8" modified="2014-09-03" version="1">MMVKVRHVLAAAVLIPAVILSADAPYYLQDTPTHDVLKRAYAVATVGLLRHCVKVSKYIEESAPATLNRRDTSSVESMANDVNRAILNVAAMFGVTEYDLHLGNNTVSDMEVVLKGKELPAHVDFKTIYEQVKSVLDRCKIFSNFMEKLLRRKNEEGDFKLDHEDIDDRILIEFPKIWIGPLHMVYKSLNLNSRSIEPGEILGARLQLWGAEEFKSTFSAIERVIEDVSFYYPQLFQKRANELIQKMWDEILANKNEENSEAIDALYKLSTMNEHFRIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCG6</accession>
    <name>A0A061DCG6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin assembly factor 1 subunit C, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0402700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769968.1">
        <property type="nucleotide sequence ID" value="XM_012914514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCG6"/>
    <dbReference type="STRING" id="5866.A0A061DCG6"/>
    <dbReference type="GeneID" id="24566323"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402700"/>
    <dbReference type="OMA" id="AWHLENE"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="390" mass="43687" checksum="C5ED3FF8E2E8F79A" modified="2014-09-03" version="1">MDAHRHNWLVNTRVLYNFISSIRLPHQPIAVEFLPELPGRREPAGDVAFCQLACGLRSEQGEKVALYLLEVALPAQPISEEIRRYSKCLDYEGFPLPGYPEPMYQCITKAELDCGIQSLKSHSYNDKCFLAAKQKDVFIFKLEGGVSEERDMKPLHTFQDHEEEGYGLAFHKVRPMLGSCSEDGRFNVWDVSELAPVYQFSSPVVLNSVELLEHENQALVAAEDGHVLIMDLRQPVVAGKTAKVDSAVNTLTIHCVNTDIFASGTASGLWDIRKLDAPLSGIQAHDAAVIKLQFNHYFPMLIGSAAEDSTVRVFDLEAPYSEDEDATPTNDEECDGEPIELLFTHVGHREHVYDFCWGTEELTETYIASVGDDYGLQLWQITDDVLDFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCH9</accession>
    <name>A0A061DCH9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VACUOLAR PROTEIN SORTING (VPS33), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768910.1">
        <property type="nucleotide sequence ID" value="XM_012913456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCH9"/>
    <dbReference type="STRING" id="5866.A0A061DCH9"/>
    <dbReference type="GeneID" id="24565265"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306280"/>
    <dbReference type="OMA" id="MQTIGEM"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="752" mass="82766" checksum="28AC21DFEBC20910" modified="2014-09-03" version="1">MSLVDRVASDARAELLSSIANVIVSIERSQSAESSASSNDVNGHRQVPYRVAGTVSSPERGESQDSAGWIRQFISKGNKLNVNCTQDVHDLVSHLFATDELSALGLDSFKTLAAQQSWRSSPRKGDGKATGGSYTLYMIRPTLPDASQLKSVLHYDRSECYVLCLPEVSDMFPGVLQGMLGKSFTVLRGIGGHHGNRVVHLYSCNVHMAPVESCVLSMFISRSFQTFYAEGDPMASWFYAKAFEHLESRIFDGAVPRVTCLGHLSRLVGEVMLKGRRDSAADLIILGSERSHSGSDMPYLTKEMNENRYRKQGTAADSAETQSAKAGDKGSNASAQATTDTMRLLRQSSVVDEAVLIDRYVDLVTPMCLNFTYEGLLDNLFGVVQGHAHLPPGVVEGSAGAAPIGILDQYRSNIASNRGALAARATQSGSVLTLSSPLYKDIRWMNYSEVGKYLHQRALQVHKGYERGDLSTLGEMDAFVKKFKNLQKEHSELSVHVNLMSWLSSLVNGDLIQLLQHMEDTILQCSSDVKPDDSKLASITAKLFNKPCDPCVALFLDLIFWNVDVNQLYRLLVLASQTRDGIKSSDLQNIKRAVVDQYGFNQLLAMHELERMGMVRINDAPDGLRWSRLCKKLNLLVDRDTGTADYSMIFGGYAPISLRLYQLIVLSRGIGSIQSELRLLNCPVSVLRQKGLVADQKRQEAKAATYKLLGYLGGVTLGEIAAVAYLNQKQSQQILLLTTDIVGMRNMLKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCS7</accession>
    <name>A0A061DCS7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770163.1">
        <property type="nucleotide sequence ID" value="XM_012914709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCS7"/>
    <dbReference type="GeneID" id="24566518"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404640"/>
    <dbReference type="OrthoDB" id="366407at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600275" description="6-Cys domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52398" checksum="1273A0BB31BAB85F" modified="2014-09-03" version="1">MNLLSKHCIAASVLAGCLVSGIVIDLASDVLPDCVEVFYGTFPNGGIYRFIRGTDEMITALHYDGHYSHRFSLLIDGLVYSHVEDFRRGEERYVRHHVARKSGGRNIQRNNIELLRQYGFFRKTTLDLVTFISGWVSLAVDARVGLPQHPVIHASCRHFTNGSVSYRVKSQFLTNNGLTVDIRPQIYKLGEIHVSNINDISLGCICRFLMESNAIVTYVDDEYFNMRTDTIDVQVDVTDMLERNVSDACITSPTSSGPLGYKGSEGGAASFDVSSQEVSAANGLMEVNEATPGAAHMATRSIYVLVPTQLGYEPRFEEYATYDPSSNTVTYDIDFLTTHYAPQCEGKTRTYIRMRAVRAVVRSDSTCVFFCAASTDAPIDSRDDAQPTESVSTSTDDANDLVDMDNFIEQMMLPGMDTISDLLNASGIPIDDAEDFELSDLQPTIGDERPALYQSAESSYDTLWAIYDGAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD61</accession>
    <name>A0A061DD61_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anti-silencing protein, ASF1-like family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0211270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768166.1">
        <property type="nucleotide sequence ID" value="XM_012912712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD61"/>
    <dbReference type="STRING" id="5866.A0A061DD61"/>
    <dbReference type="GeneID" id="24564521"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211270"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="430" mass="46881" checksum="E209A0528D586501" modified="2014-09-03" version="1">MSLVNVTNITVANNVCPVTAPLVFQIEFECLEDLKHDVEWKVIYVTSDGTGYVTGEQEPIDVAHSRDGEIVLDAVCLGPVCRGILEFEFRVSPPDFTRLNPAGILGMQAVLVTANYCDQEFIRIGYYTNNCYDDPLLRECPPDVPNIDKMVRCIIDQPRVTRFPIKWDSDIVVDPEGNDISQVIDDNPEENNTDGEEEDEEEYDDEGEDDEKDEEETKPDTAAENNGVGESGSLAPESGDVNKDFEETNGQQTNTSGDVDVAASSEVPADAGIDVGEADMAANENDVKLDDTTESSRSDSGSDDIDDSYTSYDASDEAYGYDLVGISVRPDFDSTADGEADNEADSNESSEDTDSDAIQRTDEQMGMSGEGSSEETGSRFRMEGDLTEDGVAVKRTVREVMTEGSEEDGKVRRVSPLVTVSTVTSITDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD66</accession>
    <name>A0A061DD66_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">METHYLTRANSFERASE,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768181.1">
        <property type="nucleotide sequence ID" value="XM_012912727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD66"/>
    <dbReference type="STRING" id="5866.A0A061DD66"/>
    <dbReference type="GeneID" id="24564536"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211420"/>
    <dbReference type="OMA" id="MCLEMKR"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="90"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="31472" checksum="40F06C20C959EBB1" modified="2014-09-03" version="1">MAWKEVFTFRRVCASFVAANGVVLFSNYRKLQLGRPEYKDGPPPEEKHRIAIFDSIAPTYDLKYNDVHKKLGITATKTSMLKCAKGDVLEVAAGTLESLKLYGAIESLTAVDKSVMMCLEMKRKVEDAKPDFPVTIICGDASDLPFENESFHTLVTSHALCSVEHPERSLDEIARVMKPSGRYFALERGKVYYRYLRSVLEWLKVYPNPGVPWKYGHFENRDPIELKVTDSEIFGYGMNYAIVARRQHSDKITEFANDPTPREGAKIVYQYFPHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD90</accession>
    <name>A0A061DD90_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769380.1">
        <property type="nucleotide sequence ID" value="XM_012913926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD90"/>
    <dbReference type="GeneID" id="24565735"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310970"/>
    <dbReference type="OrthoDB" id="364856at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="332" mass="36931" checksum="204271F1BCFF1E4F" modified="2014-09-03" version="1">MERDVNSSAGHSGKRSNSCMPSTHGRPQQRRNSKCDWNPPVDTSTLPAAGLSSSRCTRDFAARCNLLLHSGMKRAPAAFPSNTYEQAPSPRNYRGWNHRYGDTAPLPASTEEGVTSPKQSLQDKLRQQYARYNRVFRDPPPADPPAVKPGAPMSELEANRQRIMRHCCIFNDTQESDKRKQERDVGSSPTARPSEYASPGRSPGGQQHDITDESPNFKAPLVTERTIIGGTRTVMPRDPEWEVVAMRMSCIDALMSERDIEELAHKADMQVVSIHLDRNIISHICNGTGTIKCRHTGGEEGLMYFAQLLAKRGIRLYITDIVSRSNASREGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA5</accession>
    <name>A0A061DDA5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0311320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769415.1">
        <property type="nucleotide sequence ID" value="XM_012913961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDA5"/>
    <dbReference type="STRING" id="5866.A0A061DDA5"/>
    <dbReference type="GeneID" id="24565770"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311320"/>
    <dbReference type="OMA" id="TRKPKHA"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="385"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="740" mass="82157" checksum="203FF40C23816CA0" modified="2014-09-03" version="1">MDRDTFGDAKPRASTDFAHPLIDLGFDSPRFEPLPVQSESQVARPKAVTRSRFAPAGDAGDVAAFSNHGRHYEYADREASMRGTTQTRPAMRGPDIYECHSDSDGSVEERVMRDLTCIMGNSYYSSVPFSASGAKPSDPFATNYATVKAPSEAPAGPFQAAAMSEGAPVFFSDGEPCGATMQEAIFHLEKAEGNHNIRDTAKRTEDRGQQLRAPLIMNTRRPEDNTISKDPIISGLFSLRKPRDAGAGIVSGLKSVTKGVALGAASLVVCPVVGGHSSGFGGFVKGIGAGMLGAVALPVTGVGIAGYQIGRGIYNTPNAICQRVNGKKWNKQHCEWRDNWYSLEEEVKEVMNAIERQREAVQQQQADVDVSQRYNKRNVAVAETDFYDVLGVPPTATQAEIKRQYYKLAKQMHPDKTRDAESTEQFKKLGEAYQVLGDEQRRALYDQHGKLACHDMPILDSALFFMMLFGSESFEPYVGKMRMALFMELELGNRGCTPTANDFEVAQWDREVRLALNLRDNVRSYVCGNLETWYGEVLEKARSLCTNSFSVELVHTIGWTYNNVAKRYIGKWDTFMGIGGKVAKVQEQSKALGKTIKALTSMVKTAVAERSVSRSARNGEDENLLNEDYMKEVFENALPNILDTMLNICLMDVQSTVKKACKRILRDMVVDKQWRRKRAEGLGLMGRAFMLAAQDARQRLAAERKPLSMYEMFAQAAAKMQQNREKSPNSAMYRTDDGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDW0</accession>
    <name>A0A061DDW0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769920.1">
        <property type="nucleotide sequence ID" value="XM_012914466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDW0"/>
    <dbReference type="GeneID" id="24566275"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402240"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="101" mass="10723" checksum="E420D872DA3C8650" modified="2014-09-03" version="1">MVFIQPSRVYSWLGALNMLAQMNSSSDSASGAGRSATVASMARMSLVCSSRSRSGLSAVNSAWLSDTENDRSLMTLALGVSSLAILTNSGIFVRRLIRSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE37</accession>
    <name>A0A061DE37_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pseudouridylate synthase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770135.1">
        <property type="nucleotide sequence ID" value="XM_012914681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE37"/>
    <dbReference type="STRING" id="5866.A0A061DE37"/>
    <dbReference type="GeneID" id="24566490"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404370"/>
    <dbReference type="OMA" id="LNSLTHM"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="470" mass="53668" checksum="D1569284ED5CBDF9" modified="2014-09-03" version="1">MGTRSNHEGEQTADRGGSKRRKVDQNLESQEEQCKPPFRSLNATPNDSTISHFIPTTQPTYHFKNGFRIVLPYNHVYETNTKGRWFGRRLYDVMASEFAAFTDEYVRHACAHGLMKVFDRVGNDLYPEPGEHVMEHICRPNEKIWHLAIVHEQLALDTKVCILREDEDYIAVSKPCSIPVYHTGTYHFNTLVEVLKHEVLRDKNAQLYPVHRLDKLTSGVIILAKNSKAASAFCEGVRNNELRKVYVARVRGDFSPVFDNHKCLAVDDGIGDGRVACCHGFMRVVSHKLSVHEFTLDDTKSNVKPAETRFRLVSHNPELKESLILCYPVTGRTHQIRAHLKFLGFPISNDKCYNDGELCDDSSYFKKLPAVHWEVDEHGRWQLPELKFVAPQPAQLMRGSSDYHVGLNKPVEGLCHSPTGIFLHALRYIWEQKFSVSDAAPKWINDFEVDTAHTDLTKMNLWLDSAEANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA7</accession>
    <name>A0A061DEA7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769166.1">
        <property type="nucleotide sequence ID" value="XM_012913712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA7"/>
    <dbReference type="GeneID" id="24565521"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308830"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="182" mass="20579" checksum="BD90B872B76CC8AF" modified="2014-09-03" version="1">MAGMSLYPGKQCTRCHNECRYSYVCNCCPWCCKICRDDYCDVCFGYAFKRQRNRDPSYKCATFNCKIRCAGNEYTCECECCKEKKRRGDVVAPPPPAPRSTSDSSDAQPQAAKLELSPRDKDQTQDHDSPPSPPPYSAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEG6</accession>
    <name>A0A061DEG6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0311480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769431.1">
        <property type="nucleotide sequence ID" value="XM_012913977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEG6"/>
    <dbReference type="GeneID" id="24565786"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311480"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00970">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595758" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="843"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="974" mass="109330" checksum="9104E15734F6C2D8" modified="2014-09-03" version="1">MDVSRVRGLVLMLCATWLQYVRCIDLMRCDFGDPDDLLINNALVMCHMDIDDFSSAVVTCPRRLNNIEYTLHPQPYTYEYSHLKTYVSDEGTFRSVALSEVFLTESPVTLASMGSDELHTALIIDIPNDQLFAMTERRWIFICGPRDLTLSDTLQRHLDRLNGTIEIHDIPWNPPTSLSDEISKMGHALGVFILYGERTYSRLQGCGSRPSPLFAPDNQVTVDPVTGVTSCVVDPVSDVPIGFLCDGLVEPYDCMRSLIDHNGEVVAAPEPHPYRNFHLHRPWVVGKYFDKFVLPQFGGECRCIDPGTGQVKAKIEVRGRTEYVCDIASKIFRHRVQPIRGPWCSVVLHPGSTLTIRFPIESPGATSEDEFDMDIDEASTSGPPSEDPPRYLFKTEFLPNNLTTLRQLSTAYDTYIYEEVGYQMALAGDALELDTSQMSHGEVKLKYHSSKPLALKAGTNSFLYHWTLNAINNYIFERIGAAVNVSFALTHYYDIVGCEQGPQTVFDPELSKDYCAVKPMGNGIGPIYECAYQIKCDGWQVGIHCRPGEELLPDNCESTGYDLSSNKVMMLPESVCNATTYRIPGLHVFDIGLNGDIPFSYACACVDQRGYETSRLILKYMTNEVHAYKVRHAYQRRTSLPHVLMPWREVGLAMEGATTPEYLMMSYVPQRTIKMEVGRTLKLQCENDFDTFHTINQPLNIDANTGRNKLKWFPDNPQIFFYAFSHTPDGPKLMPEKYEHSIAMTEGALEITYSEQWGIPGYLQLAISSHRGAILISKNPRNAKAVSMAFVCGKRPEPSDLSIISDGITNSSASEQPNFQIMRLGERYTWHVVEVAVETTDPYVQGCGVTSSSDELFKPETPKLNDANGRRKFGCKIDLQVAHKTAFYCPAPYALDPPNCFDQVYVDGEVKNVSNVSNSLVKASSNHFVILRFDSELIGPGETLRQTPPLECHCVTTKGVVLSTIQIENYYAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEL2</accession>
    <name>A0A061DEL2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769661.1">
        <property type="nucleotide sequence ID" value="XM_012914207.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DEL2"/>
    <dbReference type="GeneID" id="24566016"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313770"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="433"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1511" mass="168775" checksum="A6F35179A68A66C8" modified="2014-09-03" version="1">MDVDEEEPEQVGPVRESNNSIAPGTASEVALTETAALPRAPEGHAPQAERAGNTPRMPPHYARLNAKLQFLHCVMRQIDGPWCHWVPDVYKAVVTKYQRMPRGGWKVLAEYANEHFEFHKTHKEVEQMARQVVAKAARSQPTDVGEIASLHDVDSYNALQEEFDRIMAQRLREPGVIRTVKNKRNTMDSLDFTAIRSLDLVVHNYVKHNPVTDMGMLAILYQTAQDCYDKYSAKPSSSSGKKEAAERRIKELEEIGALLLKYKQKVPLEKEDRKRVYRQMDKYNMIADKPQELSYVISRTQEELQKEQDKLKNAKFKQELYNHNRMFELYTGHFYRTLENQQDADESAINEGMMIEYWAQMWVKPNAPHNGEGYLVERPPAENMAGFPTYEEFVTIVKKLRDWKSPGADGIYNYYIKWLTSLHRVIYRLVEEACTQGKVQDDWFYCGITYLLPKNKKPKSAAQYRPITCMSNLYKLTTRCATETLKREVDGRGLRSENQMGTRSNVQGAKEHALANIALNEKHKGKLLATWVDVMKAYDSIDHAYLARVIDNLNLPGWLSNFIKQTTKRWNIEIRWNKNTIMHKKVERGILQGDSLSPLLFVLCLDPLSRHLTRIFPKVELSVPGGRIFATNHFLYIDDLKFFAHEESTMRGMGREVEKFFNDIGLRINRDKSATNTEACVSIAKQMEGPETYKYLGVTETSNSLTSDGMFDIILQEICRRTELLAASKLSGKNLSMAINQYALSVINYYIGVIPMDITHFDKIDLAVRRIINAKHGHKKWANTQRLYLPRKEMGRGLHSMVFRAEAMLLRLWLTFSADEVTSTRRAAIMQHFRDTYAHISHIKMHLEGRYGMEFGVEDTTDKSLRDLRVAQNKWLYNRMHVKSTHKVLYAKREDPKLDIEASSLYLTCGILTPEEEAKVAEVQDRNLQWMTSSKKCSRCNNGKNVDHLATKCPKLLHLEYTKRHNEVAKRVHSVLGRQIGLPKEKIDAHKIESEVHGKYGWIAYDKTVKTQKTKEYNRPDIILADRRRNTISIVEVGISNHDNLVDMEKFKKQKYEDLIEDFKARQFNQQTKIRVIPYVMTWEGIVTKEHSKYRRDLGISDRMEAHIQRVVIQETHKIVMRDMRPREDYDSVEDPQVQTGWMPAWMAPVTIGNGQTRNPQPVPAKPNVLKTGVPQQWTLKLQTFNQLESKLIRLKEILDGNQCGAETVLTNARAVEPTATKTEVTKTDSGDSSTKSDGTPNQGKKVEGAQNQGKKAEGAQNQGKKAEGGQNQNNGHSEEKPGSSLVAQTPQTHTSSVQNPDPGSSGAPSTGGGQGPGGQGKGSQDTDVSSKQPAAPSQPVQPSKPGGTSPGPGSPGVTSTGGGKGPVGSAGSSGSGQPGGNGQGSTGGGNPVREPVATQAPAKLQTPTAQSPGASSPGVSGSSSGTVKSDQATTPGTTQQSNQNTSHTSTAATTTVFSGSSSGAGGGGAGGGGGDAKADAEAECSKELKTGCKALIEKITKTYEQKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEP3</accession>
    <name>A0A061DEP3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0401220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769816.1">
        <property type="nucleotide sequence ID" value="XM_012914362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEP3"/>
    <dbReference type="STRING" id="5866.A0A061DEP3"/>
    <dbReference type="GeneID" id="24566171"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401220"/>
    <dbReference type="OMA" id="LVMNYVW"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000039">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="9">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="10">
        <location>
            <begin position="943"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1159" mass="130699" checksum="9F3FE47C2BDE4867" modified="2014-09-03" version="1">MGSPSRGKKARDTSEDVDEIYSRPRAEVRELVDEDDAASGAPRGYGPPADRKDDYASGSDEEPEVLQNNKSILAREDSYRRQRLERKLSPERFDPFASSSNPEERTYSDIMKETEIMRTRKDIEKFMERERISVDEARSIDGKRSRRSGFDEEDSAAFAETPLVESGAYAETPQLQAGAYPETPKIGDATPGPEIKKRMSRWDKTPQMEAQTPTGTPMGLGGYGAATPFTPAGLQPEQYAFTTDRNRYLTDEELDELIPCEGYEIIEPPEGYIASKYVSYHSHQVPESPSFVIKDENLRKPYDIPGTPSLLLDVEVKAEDQHFFGKLFDDKTEEDLTADEITERRILALLLKIKNGAPPLRRQALRLLTQKAREFGPGPLFNQILPLMMQTTLEDQERHLMVKVIDRILFKLEDQVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLSKAAGLATMIGTMRPDIDHPDEYVRNTTARAFAVVAHATGIQSLILFLKAVCQSKKSWQARHTGIKIVQQIAILVGCGVLPHLKQLVSIIALGLEDEVLKVRTMTALALASLAEASAPFGIEAFDIVLRPLWKGITEHRGKGLAAFLKAIGMIVPLMDPYYASYYTKEVMNILVKEFSTPDEEMKHIVLKVVRQCISTEGIQPDYIRQELMDPFFKSFWIVRNSMDKKNLDLIIETTVEISNKVGLEVIHRLVDDLKDPSESFRVMVAQCIEAVLISSLGHDADQKVELDQRLEELLIDGMIYAFQQQASDDCTVLLESFGTLLHYLGDRSLPYLTQIVGVIRWRLGTQSPRTRQQAADMICKIAPIMRQCGRQDMLASLGLHLYEYLGEEYPEVLGSILGALKAIVSAIGPAAMSPPIKDLLPRLTPILKNRHEKVQENVIELVGRIADRGGDLVSPKEWDRICFDLLELLKANKKSIRRATVNTFGYIARTIGPNDVIATLLNHLRVQERQLRLCTTIAIAIVAETCLPYSVLPALMTEYRVPEITVQTGVLKALCFLFEYIGEMAKDYIYAITPLLENALMDRNLVHRQTAAWTCKHLALGVAGLNCEDALLHLLNYVWPNIFETSPHLTQSCFDAIDGFRVALGPSVIFHYILQGLFHPATKVREVYWRLYNNLYVGNQDALVPLFPLVREGVENRHQATELLYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEQ3</accession>
    <name>A0A061DEQ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769866.1">
        <property type="nucleotide sequence ID" value="XM_012914412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEQ3"/>
    <dbReference type="GeneID" id="24566221"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401720"/>
    <dbReference type="OMA" id="NFGDECH"/>
    <dbReference type="OrthoDB" id="365211at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1121" mass="125476" checksum="1637AB6F70633887" modified="2014-09-03" version="1">MADFCRFFVAAGETGNRRTLQRLRGLLANERESFRICIQTLSHLLGVRLNELTRFDRSFVMKDDVVSIYLSGELPESVTALLADLDSDPTRKHQVALQISKLLKARLHYGLDDVVQVLDGAPAKDLYSRSIACLLRICVCALKAECDMRRGTNSATAKTQVSVVDETGTSLCEVLTRCCIILCIFGAQESNLFDDVRQVQETLLRLVPGPLALHIIAAFPVVAFDGECLFTLHNRRVFVEALAAIMPELLDHILIFNRIGAQQATRKRERRRSRDDGKGAGRKRGGASRRGASNSVSAMSPASILDATLQGIKWGTKVDAYGKRGGGRSGDGRRQLSTIHIDTEGWEFAFGNIPRVRTLSLLLEFIIRFVKISRDGKVEKQMLGWLDALVSKPSFKQTFAPIFSMGSTDNFDNILQLSRILGKDIFVSHTILSVGRPADEALDMAKAAGLELLTSNPEYARKILTFLVDGVVRRPRVAIECWCALLRPLVLPRESKEIHWPGRRKVPVALLGVIERLIGVVAKHALMQNFGDECHPDEDNVHASTARQLLVMLIALVGTKKAAPKLTHALDAAHEAMAETATVETVQVMEFGIFCLWLLNMSVNSGRNKKLLAFVKQINERTLSEAIEILEGATKTGSIRSRLEALERIKRGILASRVKQQVGNQETWFDDVHLNQPNIVKWRTYYSDCAGDMLRQLTDVVLNRLPAVVPDKPPEKPPVDDNPKPTTTGRRRGRPRVVKVTTEDRNHVTYDRMANAIANYVKRAKLLLRLHKLNLTKHVEDNVYATIVAVMARFKVPLNDCVEMFALMIDSCPPQLLYKACKSKLPRLTITLLNAISLNLDDRHAGLITAVMAGAMVSYKASSRRTKLLAALMHLIARTAAAPRLLAELLGSDAKLSRVQNFVVFVNTVKIKRAYFLEARGAMNLALIERYLQYGTAPVEVAITKFLQLQMRRLMTSRAARFSISMYTKGKRIQEKPAAKGQLSTLDTLVVSTFRVFFVVNTPPETGWLSRPQGNVNDVFHWNLLGREYYIAFSTIALLFNCFHQLTNTKFMFIVEHFIGVAARINGDTHATARRSILTDHSLLRSDAVEYFYQVYGNLARRFRLKRANKLQRTKAALHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET2</accession>
    <name>A0A061DET2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770011.1">
        <property type="nucleotide sequence ID" value="XM_012914557.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566366"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403130"/>
    <dbReference type="OrthoDB" id="366453at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1536" mass="166741" checksum="89C7FC25340CBE0B" modified="2014-09-03" version="1">MDAEGRGSGGANGYPENVPKRTPRRSQVPSPSHGLNETVNAGDSTSYVPTVSNEDGSNRRVVRGTSGSTPLPPERVNIGIPSRSLLRMISTEPIVDIGSARNDDSGSGALFVDPVSTGTPTRTRRSSTTGRRSSGGKSINLSSSINSMRSASSTASQRFRRLPAFGLPFPGQLAHSADVPSPQILHRTPGLFPRLHDGNSAFSMYADKVHDGCMSSPSRLHLNRNSPLPVLSSVSAPGGYFSVHRSESTQGNRDQNNGGSFNVPLAMQSDESSTTGASSGTMSTMTPSSEESLVIEYPPNADARSHVIHHSMAPGVRRSIGNIPSRERTPRGTPRNHAGEAGQFPQQLQSPYQRETGTQDSLGNIYFRHGQSTASSYGLNGQYLTDASARQSTGGASGGSFADGGPAGHTVGSSIIHRELVETLGDELRNVHSVSEIGGIGCLNEPSGILSHRSADEGFASPHGGSGISQIRQDNIEQYIAAGNFWGNESHLIAATHDNGLLHQTTTPTARHSGGKERGSASRRSRISHTEEMGDGLIVKRSDEGEHAVDDEEEGSIFLIPDNFNVYAAPFGDTAGSSSGVKLDDDVQMYTARGQDTEDNEDDQPCAGSETLNFTFSYSDVPAAAQSHEGSNSSGSVGYEEDALFYNVPGGLSYHAGLNIQGHPGVLAPTAPMNLEDLLYNHAFYSGEQDMGSCDEPADGMTFSDRVQLFVARRASEHGPDGSTPADSQLPSSNEIELDEDYIKAQMSMMTSIEQGSAEDGTGGSVSAPPNLGTPENNDLQTMPVLTALQESVVRQEISEMGTLMPLITENEQMELIRSQHPLSPPRSTEDLMHTDDAINKLYSVIPASYSQMAVAATVTESTPEGEMVVENAVTVPDPSHNAHLELAAPLQTTDFYSALVREKSRLHSDIVPSYDERFIPGVAYGLRNIPKRLKLADMSPHGFNDESAQKGQDNPVVMPEAELLVDEAYKRVQILVGAKLCESGYSIPADSNDRPADVTGPPAASGMNAPSSTLLDLTPQKREVQEEAKQMLSEVMSKLKSINAAKEKMHQSCVSATNHATLLANATEVYSSVVKECRQLTKSIQQRQKYSEMQTNLIGFKSKHLETLRTRVAKLTQRVQLREANGQKLQHMEHLIETLRNIYAATGIRVVPLDAGSKKIRWVFAIFFNADCNTKRCIRSFRKSWHNDLVRVADNLMDGTMNKPVVYRRIKAEQRFNPEINMLVCIKVTEGGAGYGNFLPICMRSVLRCGDESSPEVEATRTPHHRTHVPVFRSDEWPSCSPILSKTPSVTRELGRFYSSGVESTNSATSDPDALETEDAPIEFPRGTSHITICPVKWDDMVDVSRGLRIVFTAPKFKTGGGSDKVWEQVLTRLLEAANKRMRQIISRWMSNNVDESHPVTLIALMREVMDYGSALSARIRVVQRELLQLLKSTCAATFTTKGGVMTVEVVFLPQAPKSPSLLCSVDVDAYDLLQKGSYTRAARNIRLRAMQHGYDLLLHYIHAAMAAGDRDLSIYDFVADACQRAGHMLYKHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEY0</accession>
    <name>A0A061DEY0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770251.1">
        <property type="nucleotide sequence ID" value="XM_012914797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEY0"/>
    <dbReference type="GeneID" id="24566606"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405490"/>
    <dbReference type="OMA" id="WNYIQAA"/>
    <dbReference type="OrthoDB" id="365135at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="388" mass="43154" checksum="83A7F27A5B86317C" modified="2014-09-03" version="1">MRENVAQASVLGTNVPEGTPSSRSCALVYTGDESLAVVHAMSLLGTVLNCLEELRDKYGLLICKRTSWDAAVALLGRSLSDNFDSCVAPCNALHELYESSCDPQSSLARLLGHAFRVDSSDLKAAEQDGDWDFLNDVIDGQLCSQLSNATMRSCNTQQNSESTQASSDTNKQTSTGLAGDDTVYRSMQRILAMERNREKCLERLLVRFVDEIPLESTSGKRSSAFNPFVEPGLEMKWNYIQAANELCNHPPDIGVTIVAGLSHMNLIRHNAAANAEEAHNSDDGEQGESSKAAEIKSHPTMHPFDAPDQFSWDDKAKCQSLRLKTLKSYTFCLSLTLNALHVNLTRLSTPNDWLPRLFFIEPLPIKNVDRRHFVGFLRSRFQFLYKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYJ6</accession>
    <name>A0A061CYJ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribokinase-like superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0100450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765902.1">
        <property type="nucleotide sequence ID" value="XM_012910448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYJ6"/>
    <dbReference type="STRING" id="5866.A0A061CYJ6"/>
    <dbReference type="GeneID" id="24562257"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100450"/>
    <dbReference type="OMA" id="RMGCIAA"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052700">
        <property type="entry name" value="Carb_kinase_PfkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320:SF3">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="4">
        <location>
            <begin position="50"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR93716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="355" mass="38982" checksum="93BE013DD8D5D7E1" modified="2014-09-03" version="1">MGDAVLENRSNSVLFVGHPLINLLARADYSVIERLGVAKGESNLVTRDTFDELEKLVNVENMSPGCSSSNSAIAYSYLGGKTSYYGLMGDDDEATAFGDMLATYGVDNIAIRVPGQRTSQVYCLVTPDADRTMYVLFGASHTMKPSDLDENIMERFDYYAVNGFMFADEDQVALTNKMVESALSRGKGVITLFANSFCIRRNGKYLKPIADVSAYISGNLEEYTELYEIYSREELFSMFEERTSGSTPQHKAVVITMGSEGAMVMCQGTRVYVPPCNVEVVDTTGAGDFFAGSFLYGVLNGWNVRKAGQFAVAMVSDIISHMGLTISKDTRAVIDAIKNADPDEIDCKNCRLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ86</accession>
    <name>A0A061CZ86_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765929.1">
        <property type="nucleotide sequence ID" value="XM_012910475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ86"/>
    <dbReference type="STRING" id="5866.A0A061CZ86"/>
    <dbReference type="GeneID" id="24562284"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100720"/>
    <dbReference type="OMA" id="WCIPSVF"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="128" mass="14442" checksum="557152BD0C873E81" modified="2014-09-03" version="1">MIPLAYRALGRAYGPLLRPQRRFVVKLAKNTDEYHASLKASELVIAKFGASWCKPCRKSKAFVEELSEEHPDVLFLEVDVDELPQIADEEGVNSIPMYKVFKYGKSIDVHIGGDKQQLKDLIAKHASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZL1</accession>
    <name>A0A061CZL1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0103750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766247.1">
        <property type="nucleotide sequence ID" value="XM_012910793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZL1"/>
    <dbReference type="STRING" id="5866.A0A061CZL1"/>
    <dbReference type="GeneID" id="24562602"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103750"/>
    <dbReference type="OMA" id="MYNSQHQ"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="125"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="245"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="355" mass="39287" checksum="3584BBC23B56475E" modified="2014-09-03" version="1">MESDDGSPLLYEEWNGRSQQGLTALPGDCKLWQHALCGSAAGVMEHLLLFPIDTLKTRLQCGWCKPRWAARVETPTAALESKRNVCSMSTTKSRFYQNLFRGCSAMAVGCIPAHVFYFTMYEALKKSGNAPIAGACATLCHDVVLTPADVIKQRLQLGLYRGSWHCLKHVVTHEGIQSLFRSLSVTLFMNVPYHTILVSVNDFLLRTHPGGRDRCGIATYFLYAGERPVSCVQITTKHTRVCDGARLRLSCIGGAVAGALTNPLDVIKTRLQTQGCYLEAEAASKTRYKVGEAYLAHVTWGQNPIDTARAIYRQHGFRVFWRGTGTRMMLCVPAAAISWGTYATLKNIFSRLNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZN1</accession>
    <name>A0A061CZN1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766267.1">
        <property type="nucleotide sequence ID" value="XM_012910813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562622"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103920"/>
    <dbReference type="OMA" id="RISAGYH"/>
    <dbReference type="OrthoDB" id="361109at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1339" mass="147080" checksum="46111D31439C890B" modified="2014-09-03" version="1">MAAGNRLSGLTAFSRAVHLGLARVNAQAALTSVGAAHSTAKAAYGYLSQSRTTPVYKAAANNANKGKAGHEIPLGEAASEKSTRTVPPPASQRDGRVNAYTKNDATHKKGGDSGPRRDERRQDPKRVSLQQDSRFLNPQNDEPENYYDIKDPRNAVPSPGFDENDRRAKITSREDATDEIELEFDGEPLPHRNASDRLGTFGSRTVTLKKPCVVTKRLITVEAPIHSLTGRDVLEAVLHGLHHYAPFTTVEQLYKHVQTDSVTVGTGKGCESELLASLEDHVCLLARNRGLRVREAVMLAMIYDHQGSLRPEIRDALAVALQMQLWAFRPYDVAATVSVYGKYGSRYRPLLNTLGLVFYDMMIAGKTAVAPQGPSVDEMLAVIESYSRVDMPIKRVTDAAFGTLYQHVSQMSRGQMLTVLDAFFKLSQDGNFVELYTKIIGKLFGQPVLFVDGFQKYAERYLNANFQSPMENTDIATIGEQSPAYAPNEVMRLMVAMAKCKSEQLIHAVHNRIEFKRLWSQNIRDKIMPWKASVVEPGAIIAPGLVAPPIDHVTMVEAAGRDKVSSGVDVCRAQISGNDHATANKSVDVTGDNAANHGADVQQVTREADNQVNTSPEPDAEIPLDVSSGSVMVSYADQIPLIYEGMLRMLSDTLGFTQHPKHFSQLIYDANRSVVSKTADVCKELGVDSTFERLSRHCRAHYPFVASLYAIWRRYGTPGDSALQHTADMPLFKVDGASVQACPNTPEDVIIIHANQLIKSATDGSEENKQSGNAGLAANTVYPYLCSYERRLNEAMHALSVGGGANVDKFCTGPQVSANDLALTIRALQDYARYADHLHTETVNHLAALYFRMLFVSPSAPVASAEVTSTGSSEFLNCIMDATPTSLMVEHGHIPFTQNKNAVGNPEFYQVRHAEYMYYKPTPLFTDLFRGNAELYGLMMYTVAHKLQYSGTRGGPECDLASTVQVVCTMQHVLHPFYVIARGSTNDILKWHALYYKGVLNACHRVKGSQLKGNCIDVKMDSLEHSLGDLGDDANTEKTPKSQLSHQLPHADDNGTPGACNGAKEYFAASKTGMKELELLRDTAFAEAAADISKVMRCPLFRHSATVFALALLEYIRQAIEALQYDVDQIGLSGCAEISRTLSMLIAFQQMMEMELDVAHQTLLNKCQNDIVAVVASKVMAAAEDEPGVGRDLMALPRDTAWRGESQGGFAERVESLSIRMERQDFLRTAHAMAISLSAVELTEPLADAVHTIMQVMYKRLPYMADIDLVGAAITVTEVYAALVHTQDYSEEDPGGRLTQLVRILRVQCRELIEMQPAHTDEVYTLSTCGRLALIAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZX1</accession>
    <name>A0A061CZX1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766337.1">
        <property type="nucleotide sequence ID" value="XM_012910883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZX1"/>
    <dbReference type="GeneID" id="24562692"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104600"/>
    <dbReference type="OrthoDB" id="10411986at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="11359" checksum="2F85103169B36452" modified="2014-09-03" version="1">MTYISLGEFDDYPAAESFTRAPLDEYKGADHIETECSKTRMCKNVIEQFCVQSSAHQLQWKVEKVKVDTQSSTSHGNQANKTLAVDPKMLQHTGTLYTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZY0</accession>
    <name>A0A061CZY0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0102955</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766159.1">
        <property type="nucleotide sequence ID" value="XM_012910705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZY0"/>
    <dbReference type="STRING" id="5866.A0A061CZY0"/>
    <dbReference type="GeneID" id="24562514"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102955"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102955"/>
    <dbReference type="OMA" id="ICIMEID"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="324"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR93973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="388" mass="45086" checksum="4B083C60C93162E2" modified="2014-09-03" version="1">MVEPLVWPTPPPEAVTEANREYAESSSRDSVTDQSENDASPSETQRRTFNLFHYINYPPLRNSIAQPEGNPEDPEFRRMVSNRNYLIRILVYIHLCSALIVCGLMVLTVVGYEIRMYEEQRHPSHCLILFWLIRTLLNVCLNVWSIRYHILHMSRRRVFNCCRKIYDLGSIVWVGFAVYYNMIYPRENLWSASCRLCFFMIWLTIASYITPIMAFDLFSLILCPVVFCALRYREQGSLSPGLPRKLLAKLDVDKFENVAERIKRGETKAAYPGNTPAETPCTDNTGDTAVSISSDEAEHTEEVSDTRTHRSEATNAMTVLDRLCAICIMEIDDREKIYVMPCDIRHLFHRDCLKKWFKRSRICPICRINVADIIRNDREKQLLFTTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0A2</accession>
    <name>A0A061D0A2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0104060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766284.1">
        <property type="nucleotide sequence ID" value="XM_012910830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0A2"/>
    <dbReference type="GeneID" id="24562639"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104060"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599898" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="822"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="951" mass="106406" checksum="681A007BEF02F054" modified="2014-09-03" version="1">MEVFNTRQYILTFCAILLHYVTSTNALICDFGSAYGNVSNNALVMCHMDLDKHKTATVVCPRLVNGVEYVVHPQPTSEDNAHVNTYVSGEGTFTSMPFSDVVRSESGHNFVWLESTRSLTIMRFNKPNDELVAITEHSSTFICGPRDLVLSDELQRHLESLNGARSLKLPWASSTPLTQEIAKIGKGLGIFVLYRGRGHLPLQGCGSRPSRLFAPDNEVTVDSKTGMRSCVAEAMSKSPIGFVCEGRIEPEDCMKSLIDDKGKVVTAPRPRPYWDFGYYRPWVVAKYFSDVALTPFRGECRCVDPETGDIKAKIQIRHNSAHVCDISSMIVRNRSQPIRGPWCSVVLHPGSTLTIRFPTVDGAADYDNSMLRTSSRQTSINEYETEFLPKDLKTMRQINTYRGFNVYDEVSYQEVLVGNAIELDVSQMHRGEVTLKYHVDKPLTLRSGFNSFLYHWTLKSKNENLAKKIQATVNVSFALTHEHEIFGCDSRQTKLFNEDISRQHCSTKRMGNGIGDTYECLLHNKAHIHQAGIYCRPEERLLPGNCQYTGYDLHSNRIMSFPETVRSITPQPITGFQVLNMEIQNLPVSYACVCVNEHGYETSRLTVESSCEESRTFTVRRINGLQKILPYVSLRLNIGLILEGHRSGMFITLQHVSKKTIKLHVGTKLLLRCDLGTALQNVSNDTISPTAWLPKLHGRYHYNAIVTFRGLELITRSHNDVIAGSHGGFSVLFNDDHSSVHQALILELRKNAILISKDPVHKKNVSMRFVCGKAAQLSDPSAVSDYALHSDASVQSTSNIAYVAGKYTWNIVKVNVETTDPYMQGCGVTYASDELFKPETPKLYDSYGQRKSGCKIDIQAAGEAAFYCPAPYVLDPPNCFEEVLMGGIIMNVKDISKSLIASASNHFVILRFDSELIGSGETLRQKPPLECQCVTDKGIVLSTIQIKNYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0K2</accession>
    <name>A0A061D0K2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766507.1">
        <property type="nucleotide sequence ID" value="XM_012911053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0K2"/>
    <dbReference type="GeneID" id="24562862"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106300"/>
    <dbReference type="OrthoDB" id="514276at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28057" checksum="C5298618D93D41D7" modified="2014-09-03" version="1">MASNILVTKSFDPARSHPFLSNKFKRRDPNVHFYLPIECPLLKNCTEGSCPLAHTKLEVIFHPIVYKTRKCKMISMGACSFPQKCTFYNNDSEKMAAQLLWIAWERTWDLWRVNIEAVLSSHNKLNSNIAKNLSIIKNYRGNVKQFLKTINGTNNGRHLLDGRLDSILRSQFSMPAPNAGTDEPRSYSLPLATSNNLSFKFNGVGECLKFSDLLDLSPSSIRNFDASDSDSYASLIMNSLRNVSQKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0N2</accession>
    <name>A0A061D0N2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0106650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766542.1">
        <property type="nucleotide sequence ID" value="XM_012911088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0N2"/>
    <dbReference type="STRING" id="5866.A0A061D0N2"/>
    <dbReference type="GeneID" id="24562897"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106650"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595651" description="peptidyl-tRNA hydrolase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="186" mass="20470" checksum="0AD593AEAB76C74B" modified="2014-09-03" version="1">MDTQREATGAVLLCIIAWIIGVLSAPIVTDASEVWRRVIRRAIIDVKNALKRRRADKKEAQSEEDEDEDTEVKLVLCVRTDLDMGKGKIAAQCGHASLGAYLESIEQNNPYLDQWLANGQKKVVLKLQSSEEMMTLRRSAKAADVNYHITCDAGRTQIPSGSYTVIAIGPAPEGVVNKITGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Q1</accession>
    <name>A0A061D0Q1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribokinase like superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765903.1">
        <property type="nucleotide sequence ID" value="XM_012910449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Q1"/>
    <dbReference type="STRING" id="5866.A0A061D0Q1"/>
    <dbReference type="GeneID" id="24562258"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100460"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052700">
        <property type="entry name" value="Carb_kinase_PfkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320:SF3">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595652" evidence="4">
        <location>
            <begin position="24"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="5">
        <location>
            <begin position="93"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="367" mass="40046" checksum="A1336D3A39824096" modified="2014-09-03" version="1">MNGSYLFAAVACVFAAFVQYAKCIPGSGDEKLIEGPSRVLFVGHPTMSMHAPVVPSVIENLNIASSGIESVSAEDFRAIRDTVDVEANNPGDSSSNLARCYAALGGQAAYFGICGDDDLAQHFSDALLHYGVDDLTVRVPGLSTTQMFSLVTPDAENKTYVRVEASHTLKPEDLNESIVEDFDYYAVNGFMFADEEQVKFTHKMVDAALNRNKGLITVLGSTECVKKYGELLKPIADKSDFLAGTIEEISELYQVPDRKELFRMMTQRTTGIFPQHRGVILMMGSKGSVIFYKGMHYYVPTEAVESVDRTSANDFYAGAVLYGLLNGWDVRAASQLGLTVYGDIITHMGTLLTPRGHSKVQLVKDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D139</accession>
    <name>A0A061D139_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamyl-tRNA synthetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0108340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766722.1">
        <property type="nucleotide sequence ID" value="XM_012911268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D139"/>
    <dbReference type="STRING" id="5866.A0A061D139"/>
    <dbReference type="GeneID" id="24563077"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108340"/>
    <dbReference type="OMA" id="WMNKKYL"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595339" evidence="8">
        <location>
            <begin position="22"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="9">
        <location>
            <begin position="89"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="9">
        <location>
            <begin position="248"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="607" mass="68179" checksum="E095ACFE1C0031D1" modified="2014-09-03" version="1">MYHCFVVFTFLVTHLCFNVDAISTARHNSPVSLSRNATVVRNAAFVLSVHKPSSSLRLNALNNVESDNDEDVPDVSAKSVKTKGSLKGVRVRFAPSPTGRLHVGNLRTFIYNYLFARKHSGTLILRIDDTDDAREESGSFETIISDLKWLGFSWDEGPGGNIKTEGYQQSKRQDVYKEVADLLLQTGKAYRCFCTQQEVQNRKKNVKERGIELSYDKQCSHLEAASVNAKLLSGMQYTVRLRNDQFNEDIILLRSNGTATYNFACAVDDHRHDISHVIRGVDHLTNTRWQTSVLHAVGTALPTYIHCALMRNKDLTKLAKRSEDAVKISDLRDLGICKLPIVNYLAMLGTKYSDDPECRDFDQLAQLFDVNLLSTAPISFDMAKLKWLNRNYITGLPYFAFVDQLRTFLSEASDLDLSMPADKFLSLVTAAPPVLKKGVDTMRDFVSLIESSLRYKAPRFVGPDSYGYGGYFLNNESQKFLDTFTEWAQQLVAARWVELNGTNLATGNSDLGQCLYKLMDDMLHSDEFDAIEGHDHLPVVRHAFTGETQGPPLTALIELWRVAEMLSVAGFVPLRERIRRLTQVDSSATDPVAERLFSPGSRNSSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D180</accession>
    <name>A0A061D180_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal recognition particle SRP9 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766574.1">
        <property type="nucleotide sequence ID" value="XM_012911120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D180"/>
    <dbReference type="STRING" id="5866.A0A061D180"/>
    <dbReference type="GeneID" id="24562929"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106970"/>
    <dbReference type="OMA" id="FLMWGSS"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="104" mass="12168" checksum="00D838724E08A996" modified="2014-09-03" version="1">MTYYDNWSGFLQEARSLFCGRPLKTRYSVKYVKGEKCLVLKVTDDRKCCMFKLSRQGNLRQLQQFNQLFLNWSLSRDTENPEALPLKVTAAKPKSNRKVNARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1E4</accession>
    <name>A0A061D1E4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-type sodium-transporting ATPase4</fullName>
            <ecNumber evidence="10">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0107560</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="10"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766644.1">
        <property type="nucleotide sequence ID" value="XM_012911190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1E4"/>
    <dbReference type="STRING" id="5866.A0A061D1E4"/>
    <dbReference type="GeneID" id="24562999"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107560"/>
    <dbReference type="OMA" id="FNRNPWM"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF20">
        <property type="entry name" value="P-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1002"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1200"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1233"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="14">
        <location>
            <begin position="116"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1265" mass="137567" checksum="90B35134FE7FC036" modified="2014-09-03" version="1">MEQTHSDAADGEKLVSGVSIEMQPIGAENNAHPNVVERAGSSKIIESIATAISKSMIGTSITNFADGVEGEIAKKLSYGLMTADSVIELARMKDESVVERATEQVQQSHPSGFRSKFSSAPVEEIVEQFGLHDLSFGLSTVQSNLNRDFYGKNILEGSKKIPLWYLYISQFFNFVVIMLLVAAVVSIALGNIVEGVFIVIITNVNAAMATYMEKSAANALEKLAEISSPTTTVVRDGQEMTIDSKDVVPGDVVILKMGDTVPADMRLFEVNEIRVNEALLTGEPEAVKKDLVAKDINSPFATNLCFASTSVVSGSARGVVISIGMETQVGHIAKQLKKATQGNDMTPLQSSLNSLGGIIGLISIAVLVSIIIVAIVTKYEDPTRPDTNRILSIVLLAVGFAVSSIPEGLPMVVTISLSIGASDMAKRNANIRKLPAVETLGCCSVICSDKTGTLTEGKMTTTTLVVFHSVGDKWASEELSFYPTMGFNPHGGLFQNEHLTEQVKADLLQCANEERSCETAEFNVCGKDVNTATSQQVKACMLAAYLNSNGTRIEKDEASSRWKAVGNMTESPLIVAAAKCGIGSTVNPNDTTYEDHPVLPKLEVPFNSSRKMMCTVHKLKRNNFFGDIDLSRGTDVFTHVATLKGAPDMLFDTCRLTVKRDADSCKVDWESLGSGKINAQMASVHAANSELSSRALRVLLVGVFPLTDNDVESLRQCQDSDERLKWLLDGGNNGGSPLVLLGCVGSLDPPRFGVKSAIETCVKAGVRVVMITGDQKRTAAAIGKEIGLFNQFEHLGDEETGVLECSNLHISNDHSAGYLPDEAIDAHTARVSVFCRAQPEDKVAIVESLKRQGYLTAMTGDGVNDAPALKTADIGVAMGINGTDVAKGASDMVLLDDNFCTIVSAIESGRTIYANIQKFVSFLLGTNIGEIIYLTASIIIRTLPPVEAMQILFLNIVTDGCPAVALSREPSDADVMTKKPRPRSQPIMTRDWWLFGNLPHTIFEAAMVICSILVGLYVCTGVIFMSDIHKQCSSVTLKDASGNSHNFMYFCKSYEYRVERGYVGWVTNINYFDVVHGEIKTALGAIEGKQEILRPDTEGLWKEVASSFKNIGTGDVPEEHKDKLERDEHGWFRPKSGITVKGREDTPFGAAPHGYFDITARKSTQARTISFITAVWCEMLRAYTVRSWDYFYRVFNRSPVMHIACGASATVTFVATVVPRFNTIMHLVSLPWWQYLLAVGFAMVTLVLDECVAKVLYRRCAKHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Q1</accession>
    <name>A0A061D1Q1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766248.1">
        <property type="nucleotide sequence ID" value="XM_012910794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Q1"/>
    <dbReference type="GeneID" id="24562603"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103760"/>
    <dbReference type="OrthoDB" id="366476at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599940" evidence="2">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="294" mass="33170" checksum="F2F3386F0F743B37" modified="2014-09-03" version="1">MAVVAALLALQAVLHLISLEAFRVAPSGRAAAGGRYRTFFAERSNNGPVSDSSAVGVVGWHGRSPSLLRMSSSDSSESLDTSYSADNSEMDDSGVEADYNRHDAFGYSTPADLGSSMYLLLRVFESSRLREEGELHELLRRYLTSLVQEGFFNIRVYRESAGGTPPLFMVDFNSFKAYDFVRAQLLSRDPSASEILNTFYFHISRYNPPTDSYASRPRSYFRVPRYGRRSSSFSPRRMQRRLFFGSSRYEREMVPQYQLPPPRVTALYQPSPPPQMIPMHMPPMLHAPPSPYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D264</accession>
    <name>A0A061D264_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766894.1">
        <property type="nucleotide sequence ID" value="XM_012911440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D264"/>
    <dbReference type="GeneID" id="24563249"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110060"/>
    <dbReference type="OMA" id="EWEIRRF"/>
    <dbReference type="OrthoDB" id="10554803at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595896" evidence="2">
        <location>
            <begin position="24"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="414" mass="46226" checksum="A6E696C3F60E73E6" modified="2014-09-03" version="1">MRGNVCAGYVALLLAYQFVLVAAFSLRAPVRIAQSRSCLPRLLRGCGGGSHTSPPFWRIRSRNSQINAAEAVERIFCADPEASSISTAPPLNVVEGFFAIKRETKGPQLKQSLARAQIEWSEWEIRRFGYKLGTANRQLRKLAEKHKVMRNSFTSSKEELDKLRQAKHEVSVKLRIASRLRRLFITYRNGLLTNAQPRVPYVPLKYRNENVPTDFYSLGTRKSNNVKKSRKLKQQKEVERENRIRPGSQTTEELTDHQGVELSPSVGGRKGVHNVRSYSNRKSVPGDPDKSPASSVSPHWEADDAVPSLHNPGDEPLDRFGNTADPESHPDSGLLTHKAGQRSSLGDSRRQQGKSSGGVNKDKAQVEREILGLIAEAKNQAVGKKGLVSNPTLAKIQARYRNNSRPYRRLPKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2G1</accession>
    <name>A0A061D2G1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0105860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766463.1">
        <property type="nucleotide sequence ID" value="XM_012911009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2G1"/>
    <dbReference type="STRING" id="5866.A0A061D2G1"/>
    <dbReference type="GeneID" id="24562818"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105860"/>
    <dbReference type="OMA" id="HMEVFVR"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="250" mass="26938" checksum="A1FCC2ADBCB3C61B" modified="2014-09-03" version="1">MVGMLRSDGRSYLDLRPLVVELNPLRSGPSCRLTVAGSADGSGDEGEPTSVQAVIYFLADNRNRNTVGAYHRPTFEVYVRPPRGPVKGYIRGMECLLLKTLQNLVDVSSLGKVLVSVRIQVLSEGSGLLSMCLNALVTCAIISGLKLHEIPQAVQFGILLRNGSGGFIADPTPEELQKKCSVGVTILCSPQSGRIFLTTVDYGGGGYEDFLQERLEEAAKQLAKSRLIDINNKYREAFGPASVSFDANGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2J5</accession>
    <name>A0A061D2J5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767187.1">
        <property type="nucleotide sequence ID" value="XM_012911733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2J5"/>
    <dbReference type="GeneID" id="24563542"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201580"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="393" mass="44386" checksum="50C08CF649492F23" modified="2014-09-03" version="1">MTRPIRQRVILRAVIVTRITTRMETRESLKDISEMKATLKDMREMMKPLKDMREMKEIAETIKSLVDLLQRGALHKDVVAPCKLKTPHPDGGAGTSPSGGGQQQLCSAPPQSQHARLQAQSVNIPKTCVIKKSPNLRAHQRVVYNSLAHVPRNFKECIDWLMAVRGDDGMKNLKVLEAALYDFYAHMSGRFTEVSDLDKVIRVSREFLEQEKLKKRRSVKRILIKLNDRLRKTPDQLAKRIGSAHDTKNEKYLQKKGLTADTIAENLCYVVDACAKFLGRIKNRSHYKSAYSPQATWDASFSAHPETGVVIFVGIAPMLCASISSLNAAVFAAMLRFPPFIAYKRMQEMIEALGYVEPQRRAGMTASYVGDALDGFEETIDFIFDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D342</accession>
    <name>A0A061D342_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Palmitoyltransferase PFA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767219.1">
        <property type="nucleotide sequence ID" value="XM_012911765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D342"/>
    <dbReference type="STRING" id="5866.A0A061D342"/>
    <dbReference type="GeneID" id="24563574"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201900"/>
    <dbReference type="OMA" id="VAVQTFH"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="272" mass="30558" checksum="C3E67CE644192B2C" modified="2014-09-03" version="1">MLEQPMGSLAGAAAVKKTNTTCFRNIALFITVFMYAGMMSIVLRPYLSPLSAYGFVIAATFNVVFGLFFISFIRVSRRSIPLMLQQSSNTDPGAVPTNWGFYMGDDTKRRRYCKVCNVWKPDRTHHCSACNRCRKCLQRIVHGSCSVYYLINESMLSESADDLAKHDSGIRAIANIYVCVMVFVGLALIFALIPFVQFHFKLVLKNSTTIENLDDATKDQGLYDMGIGANLQQVFGVNPFCWFAPCNLPLNRPVGDGVRWTQYYYDNIPEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D366</accession>
    <name>A0A061D366_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
            <ecNumber evidence="4">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BBBOND_0108350</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EC" id="2.7.11.23" evidence="4"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766723.1">
        <property type="nucleotide sequence ID" value="XM_012911269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D366"/>
    <dbReference type="STRING" id="5866.A0A061D366"/>
    <dbReference type="GeneID" id="24563078"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108350"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000396">
        <property type="entry name" value="Cdc2-related kinase 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000184">
        <property type="entry name" value="cyclin-dependent kinase 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 25 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 28" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12 25 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 26" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CDR94537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="295" mass="33639" checksum="1B69AC79D3E5B651" modified="2014-09-03" version="1">MKRYHKMEKIGEGTYGVVYKAQNSHGDIFALKNIRVEEEDEGIPSTAIREISLLKELHHPNIVWLRDVIHSDKCLTLVFEYLDQDLKKLLDVCDGGLESSTAKSFLYQLLKGVAYCHDHRILHRDLKPQNLLINREGVLKLADFGLARAFAIPVRSYTHEVVTLWYRAPDVLMGSKKYSTEVDIWSVGCIFAEMINGVPLFPGVSEQDQLKRIFKLLGSPDIITWPQVLELPAYNPDFGFFERQPWSAIVPKLSGAGVDLISKMLQLDPFQRISAREALCHEYFNDLPENRGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3F8</accession>
    <name>A0A061D3F8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0202850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767314.1">
        <property type="nucleotide sequence ID" value="XM_012911860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3F8"/>
    <dbReference type="STRING" id="5866.A0A061D3F8"/>
    <dbReference type="GeneID" id="24563669"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202850"/>
    <dbReference type="OMA" id="FEERMMP"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="143"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="224" mass="25995" checksum="37C66ECF41CC773E" modified="2014-09-03" version="1">MPRLNGVNSKALEAKQRKKEQREAIERKKEAEALDKYWEDNDKLVQAKQERKLEAQRRQQERLQRKQETRQLLEKEDAELVSNKTCAKGAAVPKVTRAEILRIQALQAEARAKEAASREENPYCDVTLGNMNHENMRERMLLEEQNIDLVKASGLDEVLDALAIGPRVDANAEKRVKAAYDAFEERKMAELKAEYPNLKFSQYKDMIFKAWKKSPENPMVARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3J1</accession>
    <name>A0A061D3J1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767339.1">
        <property type="nucleotide sequence ID" value="XM_012911885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3J1"/>
    <dbReference type="STRING" id="5866.A0A061D3J1"/>
    <dbReference type="GeneID" id="24563694"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203100"/>
    <dbReference type="OMA" id="VNECPAA"/>
    <dbReference type="OrthoDB" id="330952at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="340" mass="37645" checksum="D87DB4833402424A" modified="2014-09-03" version="1">MRKVDGDNGVATKPSARPPMPSSRVPTFVWMLLNISCIGALLVEGNAILTPYWRTAETIAYSYMLMGTRRQHIVGTTHFGLLNVSYDEGSLIQPWEQRLESVRAKAFTAFQFHDQDGKGTYRSIEASFCPEACKSAIMIRINAYESMIAVNKKLLLALVLGCVMGVMGIAWYVFFEESVMISAGFWVSAAALMAGTTHYWSGRMRVFWTTVLFSQQVPYPHDGLNVRYTYMVAATLVCNALLLSLSGAICAGLHTYRMKRSLQAHLRKQQEGVDPFNDPTSFNMFQQGVPSAPPAGPPQASLNPGQLFSGIGFNQAQQPNYQYQANSATGPSMWNTNLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3S6</accession>
    <name>A0A061D3S6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766903.1">
        <property type="nucleotide sequence ID" value="XM_012911449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3S6"/>
    <dbReference type="GeneID" id="24563258"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110150"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="149" mass="16910" checksum="14851E845B459379" modified="2014-09-03" version="1">MPLDSAQLNVLRWPQVDEYVNSIRANIKSNREQQVWKESGRPDNGATTQPRPRNDPRISPEGEDHYDILRNEVRRMDTRRHIGEIQPRRGGARTSYGLGDRRTSDPQAGVTGTRSRSRLSLLKGVLDATTNAMTFTGREKVELVQDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D481</accession>
    <name>A0A061D481_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767038.1">
        <property type="nucleotide sequence ID" value="XM_012911584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D481"/>
    <dbReference type="GeneID" id="24563393"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200090"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="187" mass="20377" checksum="E6AF5DDE6437FAD8" modified="2014-09-03" version="1">MGSGDPCICGTGCRMGRSCVCCPWCCATCKSVYCGECWGYYGLRKQGKQLDKCGTSQCKIKCIDVYNCQCKCCRKKCDDKDATCKPLPPPPPVAATLSSTGAQVHSAPSGAQHLQATEEQSRNLEAQTHDEYTSPSFTPDPQAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D494</accession>
    <name>A0A061D494_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767747.1">
        <property type="nucleotide sequence ID" value="XM_012912293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D494"/>
    <dbReference type="GeneID" id="24564102"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207190"/>
    <dbReference type="OMA" id="RVNCKNV"/>
    <dbReference type="OrthoDB" id="366307at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="201" mass="23079" checksum="C0B027B8A857552D" modified="2014-09-03" version="1">MTLRWLLEHVSGLVERRCVHFSKPAPNCESSRDPPRRFCRGGLRHHGEWISTCALISRTLRAEGMRCDVFYSTETGRRFVRALESRLCSLNAQQLFQVLLAGRKFEAPIECVVLRELLPQLSRLDTVSVLRLPTLVASRDPALWRVLWQVRRILRVSSVVGAGFSSDRCQKWLRSPGPSGDPSARVVEVWRRQINVQLNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4B3</accession>
    <name>A0A061D4B3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767604.1">
        <property type="nucleotide sequence ID" value="XM_012912150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4B3"/>
    <dbReference type="GeneID" id="24563959"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205760"/>
    <dbReference type="OMA" id="GTNPLMC"/>
    <dbReference type="OrthoDB" id="363802at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="220" mass="24708" checksum="78EDEC19460E55CB" modified="2014-09-03" version="1">MFDLVFGILDVKKGVRRAHRILTAGDEPDACASFAELLSRVYDLETLLVEVDGTSSLPNGDVPRECAIPKDDPYLARVPLECMFAEIRRRNWYRGAILDFFTPPESENFLDAATDTTLISGVHVIVYVTSYDKYRTGFSAAVKFFRINRNCAAIKFLVVDVSSAQNVPSVDAEAELMRFIESEPEVSVYKVDLDDEPRRGFLSRSILDEAVMCINMYGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4B9</accession>
    <name>A0A061D4B9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2</fullName>
            <ecNumber evidence="1">2.1.1.296</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0207410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67024"/>
            <dbReference type="Rhea" id="RHEA-COMP:17169"/>
            <dbReference type="Rhea" id="RHEA-COMP:17170"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167612"/>
            <dbReference type="ChEBI" id="CHEBI:167614"/>
            <dbReference type="EC" id="2.1.1.296"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.296" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767772.1">
        <property type="nucleotide sequence ID" value="XM_012912318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4B9"/>
    <dbReference type="STRING" id="5866.A0A061D4B9"/>
    <dbReference type="GeneID" id="24564127"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207410"/>
    <dbReference type="OMA" id="CINVSNT"/>
    <dbReference type="OrthoDB" id="429597at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120550">
        <property type="term" value="F:methyltransferase cap2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025807">
        <property type="entry name" value="Adrift-typ_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF2">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51614">
        <property type="entry name" value="SAM_MT_ADRIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adrift-type SAM-dependent 2'-O-MTase" evidence="7">
        <location>
            <begin position="126"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="972" mass="109744" checksum="A04FC654E92685AD" modified="2014-09-03" version="1">MATAATEKTPALHNEKRFVFQGSLNRLLADAKRVPPSATPCQKCVQRKRVCICETVTSAVGRAPAYEIAELAETRTMLSELRDSLNGVDIEKWSVHTRLLDQTSLVAKQVSEITTVVNGRREPGVELVTNAWLKLYDILQTYKVLDAVKPDLDTEGGVVRSFHISECPGGFIAALNHAIKQRNSLAELAWQAISLNPYHEGNSHGKCLAEDILFRETARNWLNGADDSGNVTRTLNIEYIWDRISRPSRFNKGRSPVLVDIVTADGSFDCQADPNNQEALTAPLKLAEVVCALGLMRVGAIFVLKMFTLFEESSLSIMALLNMCFKTVEVYKPHMSKANSSEVYVVCMHFNGITSVLLCALCKIVSEYAANHHRRAILPREWVPSSFRTEFVECATMFAQLQCRSLRSAMAQFLQVTDENAFYKRKREFARLFISQFKISAIPSDCRLVKYISFSENTITGKDTSSLLHVPKRILPDLDTRRNYVKCYKDLQARRVELHRQYAQKEDPSHFITLGEEATSAEFGRDIADALRFANEFKPPYPQLNDGTLMLDLDERLLSELRADMLNQRYLKDSWFVAAPLQAHEVRMSHFVCNDLLYDVSRMRTLCGARAPIVTAMDALCVDGAVGEALSDINMLPNGGMVDLAVISQCFLDINRYKAYLEITCNAGQQFPAVSLLKRHGIPGSIIYGFKANGDASSHIQFDSSYELQVIVESFLGEGTVNQCIDFKYDECLTRGEGHRCLTAQLQESPIRNSCDFVFCDTTNSSVHHREVCMDEFKSKPVIVAQLVQALYCLSPDGDLVVSVRTIITRFSVCLVTVLRTVFDEVHLYRPDSVAPWTQRCYIICKRYNDREKNHCRYYLQCLWDAICLHKKAGKEVVQTLRPHHFTYFARKLWEFNTRLFLSELDDIAAHSKGESLKADRKNVAVQLLQNLGVVDILYPPRLLQAQGPCRLPLFQNVSVVNIQLVSTNYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4K8</accession>
    <name>A0A061D4K8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase III RPC4 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0102030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766060.1">
        <property type="nucleotide sequence ID" value="XM_012910606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4K8"/>
    <dbReference type="STRING" id="5866.A0A061D4K8"/>
    <dbReference type="GeneID" id="24562415"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102030"/>
    <dbReference type="OMA" id="LGANQHT"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24782" checksum="C4F2B54058E07F99" modified="2014-09-03" version="1">MDNLFSDDESPEAGGEDAGYLESLTDLKLELPAVKTDDPNQDEDGIDICSSEALLELAESNPSLLIPSVLPEPKEIRAEESSVMEFFNTPGTHFMHIQMPNAMPHLDKERTLQEDPAARTDGSSAESSPCSTPPEEPDEPQIYQTSRVDCLPSGRLGRLRIHRSGKIQLHVGGHVFNFTQGSRVSCKQQVGCLLEENDEFLFLGNYRKKFVVSPDFSAMWNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4L7</accession>
    <name>A0A061D4L7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767704.1">
        <property type="nucleotide sequence ID" value="XM_012912250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4L7"/>
    <dbReference type="GeneID" id="24564059"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206760"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="332" mass="36549" checksum="C2FA29A564370EA3" modified="2014-09-03" version="1">MVYTSLTEAPRNFREGIDWLVALKRNGFENNLKAISDAVYNFLADKPVGSAQLPAFQNVKLITKEFMEQEELKDHLPVKLMLTRFNRPKDEKTNVFAMVLNAAGDRDDTHIGEKWRFNAENIAQNLTKTVNGCEKFLENVKIPNQYESAYSSEATWEKSCSEKPENCAAVFVGIAPMLYTGLMSLLYATDADEFTLSPFKAKKNLGDLLNALRYVKPECRTDMSRSDVVNALNCVEHPAFETLHQLSEFWIFHGSNNDGAVEGMEAAKSAGVEEVIEPVNAAEPVNALKAEKPGKPEKSGKSGKSGKSGRSGRLGKSGKSGKSGKSKKSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4M1</accession>
    <name>A0A061D4M1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Calcium-activated BK potassium channel alpha subunit containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0201540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767183.1">
        <property type="nucleotide sequence ID" value="XM_012911729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4M1"/>
    <dbReference type="GeneID" id="24563538"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201540"/>
    <dbReference type="OMA" id="VWIPYEM"/>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="13">
        <location>
            <begin position="290"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="12">
        <location>
            <begin position="532"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123158" checksum="3FFD5EB1E205A383" modified="2014-09-03" version="1">MSVVPDDKKLRTDARTLKTFIKGIFDCVLITVLTCSLFVTVITAVEHDSLWDEFVPIVVGAVLFPLTLYIFQVIQTVIKTIKDSLVLRRRQVDGLAHIDTSVGRFNEEQPGRFQHTPKSIAILALKKAKVWYSYAKLSLTFMMHNSYITLLFWDSLKLTLWLMTLTYWRRNHHTQEWDFSRTPQSIYRLHYGSLSLTNTELCLFILGTTDIKDVLCSSLFWINICILPPMTLFVKLLFFHHLTFFKIYWMLGFLIWIKYFLLLDRLINIFNVGIERRAHRVWKIALGIFLMASAFASSMYVLQGIHPSEANDNAYSYSLAQYAEFFYFAFITFATVGYGDVVPMTTETKMVSVCFVSCMIVWIPYEMNNFIQGVGSTNRISGHISSWGPMEAFIILIGDVDPIQLSLFISKVYYAGLKLKIIVLSNLSIETYETQINQAKLLRLSLCIIRDDIGLDGNVDILHTIKAKDAAATFVLSTFKNPDARKTDMNTVARLISLKKFGLSSDNVVVQFCSSIGPQISLHAFGRNMNLYRFKTALIAKNITCPGIITLVINLSLTHNAVMPQDRKQQQECRGSSDLYTHYLIGIGKRLRICEIPERLVGVSFETLCLNLYNRHGYITIGVMHADSAYHTYHLNPASHDYVINQGDRAILIADSTSTASVETDFVAAGRHSSSVALRNTMITMFLEKWGNVVHVEKDGRDDVDGAIEILPPPLYTSAESKFMSERENLMDHVPDVNSIIVTSITFASRYVYDNPSRPIIAIIGYSEFVIHLLLYFEELNEFNVVLFGRQVWPLKKLTLTEQISSKANIAILQRFRSFLALIDGDPLKKGDVNRAELDRACYLYVLRSPDLEEPGISDIDLDLQTIVTYRHLKNIIQSNMSEKNAVNNPYSNIFSLVELHNASNVSYLDDSKWSAWNVLDKRLDPSLAYIHSLEYSMGQFISDEMLYSLCMNTMLVQEDFSIYRILMDLACVRDSAHKFVSDVASGSILAQKGLMLIPTTDITLDSNKRTFGHLFNYLFEKRNMVMIGIYRVGNGPMENCVICAPPPNFPIHHIDMVGYIDRELNWVQAYVISHNNGARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Q8</accession>
    <name>A0A061D4Q8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766120.1">
        <property type="nucleotide sequence ID" value="XM_012910666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Q8"/>
    <dbReference type="GeneID" id="24562475"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102620"/>
    <dbReference type="OMA" id="KHSCELE"/>
    <dbReference type="OrthoDB" id="365838at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32632" checksum="750B1A42C59165C6" modified="2014-09-03" version="1">MPDVAVLLEALSTLRLDVEGDDGNSELLSRVSEAAEALAAYVADDSAEAALFSDFENLHESLRQKRDAELRDANASVDKTKQELSEAEATHTRLTEELRSLKAKTEAAIGECVRPFGVIGAGTDGNALAAIHEAQQMKDELQQLRTVEERLALDIRGLEHKLQTLDEVEKQHLAIRDDIVKRDKLLYEFVTSSLNITVVDRNESQVQLALLSESEDRTTQTWDCMYANLDECGPETADRLWEAIEKTFDPDSVKSSGDTVFDMLDIGGYDDFHTYLVWRAVISGSPRRNMTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D526</accession>
    <name>A0A061D526_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongation factor G 2, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0209390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767972.1">
        <property type="nucleotide sequence ID" value="XM_012912518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D526"/>
    <dbReference type="STRING" id="5866.A0A061D526"/>
    <dbReference type="GeneID" id="24564327"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209390"/>
    <dbReference type="OMA" id="SMINTRV"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="47"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="779" mass="84426" checksum="DDCF86E00A4FCC2E" modified="2014-09-03" version="1">MGTLAALSVTPKLWTCIRRSLPLGGWRIGRSFSTDHRTSSGDAYSTSDIRNIGIVAHIDAGKTTLAEALLSRGMEQNRHGKMQQNPVQLDFMEQEIKRGITIRAACSSFNWGRHHINIIDTPGHTDFSGEVFNAMSVIGGCIIVIDGIKGVQAQTRHLNAALPRNMPKILFINKIDRPGVSIEENLQSIREHLRLTTVLINQPVEDSKSMATNRRIVSVLEENDECNDECAPMRDALTDCLCDIDDQVADIYLTDGHVPRDHLIAQLQKHVGEGRVTPVLCGSALTMAGVDQLLNAVCKLFPPPTTLGDLQSSSKGYTLVRTFKTVHGGASQIHAFCKVLKGVATPGMRLHNLELGKAEQAGKIFKIHGNTYQERSDILMISGMQSARTGHLLSTDPKKILPSEYGTALSTVSAATRCVCFATFTPKNGHSIDDVVDAMAKMKIEDPSVYYKYDPDAVDGLVVGGYGEFHLEILAEMLKDDYGIPVQIGKLTVALKESPTDIAETSLYTDATVPEVYSRHHAPDKTHIGIHLIMEPMEAGTSYTHRELGDKSTSPPSEGSASPTDANAPINKVDDENVVFLSPNGSVIAQADAILASTKTREILASVKQMLHNVLAAGPLIGGSMINTRVRHGKTFMHGISDKGGENEDPAKLHCRRYCQAAIRTIRSGAKATASRALKEIYSNVPIELHQPVVSLNIVVPNEYVGNVTTDLRRQRNANIATIASEGSGSNVMSTIVANVPMKHALGYTKALRALTNGNATFTMVPCGYTPVPANEANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5H6</accession>
    <name>A0A061D5H6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766405.1">
        <property type="nucleotide sequence ID" value="XM_012910951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5H6"/>
    <dbReference type="GeneID" id="24562760"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105280"/>
    <dbReference type="OrthoDB" id="361261at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007378">
        <property type="entry name" value="Tic22-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04278">
        <property type="entry name" value="Tic22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="243" mass="27530" checksum="6960BDC42FEE7ACB" modified="2014-09-03" version="1">MIIFMLLLCQATLGLYIGRPLSNINFGSIRKDVPSHFFHSHLGNAKDVPIFVVESITSPVITRITRSEKIVTAFVDPRDAIDYLTELTQAGSAVEYELPSLRIRILTLQELFEKIDPTKPRISSHIKYKLVPSSSQLPLASLYLPLSYKNDVHIPLFYSKALNISPTEGKVLTPLFWDFADLTASINMISDLQHREALIKSIGILSLFDILLENPRLDGYYMVPSLQALQFCQKEKNKTLFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5K6</accession>
    <name>A0A061D5K6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0209760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768009.1">
        <property type="nucleotide sequence ID" value="XM_012912555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5K6"/>
    <dbReference type="STRING" id="5866.A0A061D5K6"/>
    <dbReference type="GeneID" id="24564364"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209760"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="400"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="488" mass="54949" checksum="F8CE7C0B3E5D1BC5" modified="2014-09-03" version="1">MKLNVLHRRDADYVAQGPHDRPKPMRNLDPALHPLPRQREYVRAVVAAKLKRMHAKPFIAALEGHTDSVDSMSMSRRSLCDLFTGSCNGEIMMWNMLTKRKGNIIGTHEGFVKGLCTNGDGTLLYSCGHDKYLKCWKVPTSGPIEDEEPDEQGDDAGQQRSAHLQGAISDVKVRTTPPPEVGGPSDARRSILTQPAGSFLTNSTLNGLDHHWTESLLATAGDSLEVWDGQRSAPIMKFDWDSEALYCVRFNYSDVNLLAAAAADNSVGLYDIRANSPLRKLVLQQRTNAICWNPQNPLHFTIANEDSNLYTFDMRRLQRALLVHKGFTNAVTDVDYSPAGTEFVAASFDKGVRLFNLEGKSRDAYYNRRMQNVLSCRYSLDGKFVCTGSSDMCVRIWKSEASLKLGPMSHRERAAYNYRNALQEKFADLPEVKRILKPRHQPALVVKQSKLREAKAAAKRRRDVNRALHSRDGEIIQEKRKPIIRQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5U8</accession>
    <name>A0A061D5U8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768119.1">
        <property type="nucleotide sequence ID" value="XM_012912665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5U8"/>
    <dbReference type="GeneID" id="24564474"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210830"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="8070" checksum="7963A5AF46BAD094" modified="2014-09-03" version="1">MKLKPHYLSRRYNFYKSFSDLANCTTMANYRFTNRYATTIRKLYAKLLAEWYSNLCFLPDMLSISSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5U9</accession>
    <name>A0A061D5U9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767573.1">
        <property type="nucleotide sequence ID" value="XM_012912119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5U9"/>
    <dbReference type="GeneID" id="24563928"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205450"/>
    <dbReference type="OMA" id="HYKSAYK"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="319"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="413" mass="48680" checksum="D80BFBD404E91D71" modified="2014-09-03" version="1">MAILRAREQIITRSIRREARVRLHGKRVHKRFRSWTQQRTRKFWMPIKVSLHAPTELMDGWLLSAAVQKAAVIRKHDVRLWHSFVKRVLDLSSHLTSQQIGFGKSRFLNKHFYDELMKQTEPVLSTLSSSSLMSIVWALNRLQIRETKFLTRRISELRVADLIKICNGLGRLDICNPVFKKVISENMVERLQTIYAQDFRNVINAVAMIYLYDERTQKYIMERFSKTFICARPQYLHHGITTAVAMRVLMPDVWSQLDRNTREFYTRLSTRKIHLPLNKPSAFHWDVSHALGRLGIAHRNSFYWGCYWIDIGEVEERKNCWFVDGPSCFYTGTTHYTNQVKLQHRVLENLGWSIRRIPWFKWIDLTSNDGKVSYVRNLRNSPAAGEVLTNDEWMDSAEIAIKLSKIKKHFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D612</accession>
    <name>A0A061D612_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Factor associated with neutral-sphingomyelinase activation, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768184.1">
        <property type="nucleotide sequence ID" value="XM_012912730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D612"/>
    <dbReference type="STRING" id="5866.A0A061D612"/>
    <dbReference type="GeneID" id="24564539"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211430"/>
    <dbReference type="OMA" id="QHITHIQ"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH" evidence="1">
        <location>
            <begin position="340"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117850" checksum="5955470FEB404042" modified="2014-09-03" version="1">MLSAVRSFDLVLLEEGEDYVCDAACNSTSSFPNDITAAGWPQFVESLKNVQNCRNKVIKGRIRLGTKSLIFEPDAFDSPILKLHFQNITAICSSAHVSRAIYVSCTRVISIPTAIYNGKTRYLSAYDVHVAKKAAPGLKQTPSTTTDASATASMGLPGFVFIFAYPTDHIHDEQLSDYLRVWNAYKLNVDTDALNARPAGSFNQALLQPREKPLLGCAASSIHTEPVFCWRLKRMVRHGGYAALTDRAFYFEPSPNFSRKSCKRVPIDRILHIFKRDSGMPSKGESATALEIISLPEDSFEKRVRDSRKLYGCIYLQFKRENDREKFTSTLKSIIPRAFFALESRTFRNEMTQLWRRGILPNFQYIDFLNCISGRSRYDMSHYPIFPWVIADYDSATLDLKDPKVFRDLSKPIGALNAERLLHLKTRMSTLHQADKSNSDPAAASDKEQCTCGDGKCDSCLMRMWNDGFYLYCSHYSTPALVVFFLIRLQPECQLRLYSGKFDSTARTFKSIAETFHNVLHGHSTFFELIPEFYSGNDAFLRNQLNITTQDGRLCDVELPRWAGNSSAQFMKMMRNALESEHVSKHLHKWIDLVFGYKQAGLESIKSDNTFHPLSYLSSVRVGKMPMTRATQNLLRTMEPKAISVQVREFGQAPIMLFETSHSPRLRHPHWQETDDPVDSAPWFIYVKRHSEIFAGGDSDAGEGLRLGRTISQGSSEGHLRQLVTTSPRNKVRTQRLGPLGNEITGAGFAAPDIVYSLSHNGSIMLRHVDKADSVVHASIDRRPLTCATSALGYLCVCSSSGNMTMCNLQAILSVNGGFPLNGPVANGDVVKFGDADEGGFFYRKQLHSDGISCVSFGDGVLTSGGFDETVRQYQLTNSDIRLIGVFDETNGPLAALSCANGLLLTASVSGSLTLWDPRSPHIPIWNHEIRQKAGDSRVVSCGISNRYIQLVSTGESPVIFWDVRMLNSLSSCSGFKRELAAPQFSILGAVCDPNDCVCISGTQGGVPALQLHDLHTRSVLMTTELDGLAYPTIMAANEFGGPHRLLVANTAGENLTLVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D651</accession>
    <name>A0A061D651_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TelA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768362.1">
        <property type="nucleotide sequence ID" value="XM_012912908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D651"/>
    <dbReference type="GeneID" id="24564717"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300810"/>
    <dbReference type="OMA" id="ASIDWGP"/>
    <dbReference type="OrthoDB" id="360682at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="997" mass="111293" checksum="40F682E5EA2BAAD6" modified="2014-09-03" version="1">MVRLFPGFLKKIIVHKGTSPDPDGCKRDSTSEAAASYVGRYSIESGASVNESRTTAEQGGSCTVATEEGVAKGDLLQRGITSNIATIALGEWGYPLYEDCRDDSFFSGKYFTGFLRNYVTSSDPLEDFISASRTKLIPKVEESDFAEYIRQISVFYATMNEDAPSGDGAEGADRQAAPSEVHVPREYYSEGYVLSKNDVFKEEVERIPEIMTTLEAQLDAVNCELQEMLERRYVHVHEACTSVEELHNRFLDVTKQINRIRMDLEGETTKGTIMKSLSTAPIKKEELDAILQKGISRKKELQTMLEYLQMFRAIIALPEYIQGIADSNGIAVANFLSQSVVNYLCDNLGKFKLAHSVAGVVSESILNIQRVAETKFINIALVALIDLRDTSDMKSSIDSLKTMLDQMHQPLIALTNASMLRDAMETLTLACKGAKAAIGYEKYDTWTELAKSFEGHKSRLLSYFFLSQVWGCMVLRRMLCVERMRQDKTLSMESTESVKLAEKVLSVVQDRMSSTNPVGNMTTVSTISALVSKTVVLPPMCMNDIDYWSIYQSGIRTDSNLNKTKGSDSIDADISDVLAAYVASIKHIVDTASKNSFDDFANHVVLTSNFKAEFDVSEFINFVESCKALKTQYERLQVDIKAMYLFPSMILRTLDNEWRSDKHSKMVLSPGITAIKSILPDEDRDITYEFRAIVDRVIKSLGVSCLEVLKSNNVTCVQSALAEEIWDAPYAHSYSTADGEVPFLLMKSCASIDERLNLYLLLAEALPCTGECASQDCTQLIEVYHSMIDAEVSMLHFQEADIDSSTMRKACLIAEALRYFSHRITDVVKNTINAMSAAVVAHAYEPNACPADLDAKRKGLHEAAGQCSDNLKSLSRRMLETISNEIGSKMARQMNFWVLQPSDSCYDDKALHDMIQIVQNSVDIVSKVLMDVADVQFVFANAFKQLHTVIPVEDINEQLKEDFRDSCAELITRLSHNTCIKLEIFSLADTLSNELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6F6</accession>
    <name>A0A061D6F6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIBOSOME BINDING PROTEIN-1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768324.1">
        <property type="nucleotide sequence ID" value="XM_012912870.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D6F6"/>
    <dbReference type="GeneID" id="24564679"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300430"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1743"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1822" mass="201477" checksum="AF0E8D0F0B0C45CC" modified="2014-09-03" version="1">MTQIPLDTLKQCLQFLEWLHKGSRMRGSMRSRVASQLAGHASNYYNQVVYTGDLPPTVSDFLTKVNKFYAKLCNKAIAGSYETATLAEVVNALLECIPKVLAALYFLRYNVDKKFKVLGGGGWAGNNPGIDGNRYVWRWFKSDNWGGATQRYLRATKQDREFGIPTGVVPGGFEKNDLKEGWNYYSHEGYYYSENMIDDIKAILSKNGRNDYRNIFVTSIISAAGTDIANTANAVGLLVLFCSIVLKGVTHDGGEMKRKLEEDLTDNNNKKCIDWNKLTSHCRMLKSQLEGFFSDDAFSYTGEAPSIESENETKFMKETAKWFRGKLSHVVRNVNRISRDYPDVRRSNFSPINSFAANNMFPYGFIFGEKNYGTFFDGLNTLSQKWKRVIDMINTNKSLEKLKTLLEGEGCPKFEARKLNDTNASTTNSAFTKHVASETDAPHPTVNKAGESSPQAKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKSEGAQNQGKKAEGAQNQGKKPEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKSEGAQNQGKKAEGAQNQGKKPEGAQNQGKKAEGAQNQGKKSEGAQNQGKKAEGAQNQGKKSEGAQNQGKKAEGGQNQGTEVKPDPNGTEAKSEQEPGSHQNVRVSDSQKPGAPNEVGSAVPPPPAPPSSVPAPRESAGTPDGGTPGSPGINNSSTHTGGSKVIATPQSPSRTGAGSNRSGGSRTGSDEGKGDQASASDADAVSSQGNTTTKGTDTTTSNDLGTGLSVGFKNGGSGSTGVQGSDQRSANSPNPDDKCPRSRGYRQIRLGPNSGTYCVRDDDYKRQEEINNKWYEKVKKSEDAAKRRKQDEEEKRKLQKDAHEKLQNKWHQDFIFSGGVDVYGYPLKHNPDAPLQPVFVELGGLPIMDPIKETQSNYPEAPSMIHFQQPPLADHNFPHPPVPIQHLINIPTEGALSTDKYSIHSFPTDKSGISPVKDEKRKFRESFVPTDFLDPLPPINLEVVEAYTPIKADTPPDLFIEVAKRPFADPVSVNDLDLDAPYAKTYDILRDRYQELGHATGEIKSFSDVPRTNFHLDFVQGLPGLEGYEDPGMPRDSPRQVAEHNVPLVPDTSFIQRTLELSAPHVDIDVANKWSTDTDSKPKDISLEIQHVDPLESLGLPPILPTVLVERADRSTIQNESDLPFEVSIHVPDRAVQDALHDVDLYYDHYANADSILRNEIKNAESWYGEDKDFSGLPKSNFNLDFTPAFFEYNGHQDPGIPRDPSRQVSARDLPLFPDPTQCLNPWYVDPSSKSSTFSPAPNSDHLPPPQTIRGMLFWIVGLTEYGYIERITEHVVCILEDINNASSVYQFPDSLDIAALTTSLVTKTLTDSCHFAANFLYRFKHKDVSDAFKSFFKNQDNNGFYYSPDPACLLCQLRDYVYAAHHQLQFLKAQCNRDKSHGGWQDCKYGSDITSPNSPLQAFLTDGCYSDFDTYLFDPGNICLKSRVKMGFRYEGLPDESHDGSYLSTILSPTCGGDDPLLTLSSYLNCLTRRTPRTTGELVSFFHHFGNELHLSYSKGPSNLGTALSTPHDCCPNWDHLGRPDLDAVRDFRGCQSPSSGNCHPNTLFTLLGCHIGNVHCHRHLSPITYRAYALYSPIFSHTYLSWTVYLTDRLWESLDKLLYDLDRLQCSNVRANHHCADALPLLYYHGFTPPEGMPASAVKCSDVIAKLEEVVNGDAVAKLVTCMDSFLYRIRMPFIILGFALWSAAFCLLVHAILYRRDMLRIRSHIMRCKVSHAIDVKVLLSLSRNMISLYDIEYFDDDDELTEASNTLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Q2</accession>
    <name>A0A061D6Q2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase, AAA family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0302700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768552.1">
        <property type="nucleotide sequence ID" value="XM_012913098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Q2"/>
    <dbReference type="STRING" id="5866.A0A061D6Q2"/>
    <dbReference type="GeneID" id="24564907"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302700"/>
    <dbReference type="OMA" id="HKSITGG"/>
    <dbReference type="OrthoDB" id="199596at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF12">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="331"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="567" mass="64321" checksum="C948DA333E3B5EE4" modified="2014-09-03" version="1">MFGFGSPQVPSSALPPLPKDDKNITGKFDPTALERGAKALKMLDSSPNAHKAFELTKLQELTRQQEIQKEIQQMHLRQTELGAQRARVEGDEKRKLMAQQQEQDRITAQYKAKLEAEAYQKKLQDQRRQNEEWLQQQHQQFLRQEEARKKTEMEILNMRKAQIREEKALERENMKARVQEEGRVRIEQERKNFDIHVKMMKERSIEERQTKLESLHVTFSSLGSAFSSLLADKQRLTAGVTSLTALALGIYGAKAGTRLAGRVLERRLGKPPLVRETSRWTLMGGIRNIFTAPMFPRNPPAINNIVLDNNLHQRLTWTTNSLMSAKRNGAPFRNLLLYGPPGTGKTLFAKTVAKNSGLDFAIMTGGDVGPLQEEAASEINKLFQWSKKTKKGLVLFIDEADAFLRQGRSSATGMSENMRNALSAFLYHTGTESKEFCLILATNERQVLDRAVLDRMDEQYEFGLPGLEERKRMISLFMHTYVLAPKSSGHTFEIDPDINDEFFARVAERTEGFSGRQLSKMCISLQSAVYGSGAKKLTLELADTVVNWHINEYRKSQGSVETTNPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Q9</accession>
    <name>A0A061D6Q9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribosylation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768419.1">
        <property type="nucleotide sequence ID" value="XM_012912965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Q9"/>
    <dbReference type="STRING" id="5866.A0A061D6Q9"/>
    <dbReference type="GeneID" id="24564774"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301370"/>
    <dbReference type="OMA" id="LYVINIM"/>
    <dbReference type="OrthoDB" id="365802at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="180" mass="20486" checksum="1E2EDC27870EACA8" modified="2014-09-03" version="1">MVGILERIKNFRNRESIHIFLCGLRGSDWEGICSEIEPTTLYHYEELHIRGKRFSIWDFSGDAKVKCIPAYVARSVNVAAVIFVVSATEHADSSCRELLDRIRRMDMDDAFSSSLFVILLNKISSGSQYNGLETFLKRQLSDPHRFIFVVVNVLHGLKDAAWLQLLDAIYAHHKKTVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Y8</accession>
    <name>A0A061D6Y8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766880.1">
        <property type="nucleotide sequence ID" value="XM_012911426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Y8"/>
    <dbReference type="GeneID" id="24563235"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109920"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="151" mass="17375" checksum="3520860DFF56135A" modified="2014-09-03" version="1">MSARRINSVVTCDNSSALISDLFQHLASKCLSEVNDGFGWAISFIFETQYTGTSVFMPRLTNSPNGFVSCVLGTLCIRLGTLFLSYRDMNKTLYASYDNVPPKEWIWPYLWKESGRPDNRAAPVKARERYMHWPRKKASTRRTMERDSCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7C3</accession>
    <name>A0A061D7C3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CobW/P47K domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0303470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768629.1">
        <property type="nucleotide sequence ID" value="XM_012913175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7C3"/>
    <dbReference type="STRING" id="5866.A0A061D7C3"/>
    <dbReference type="GeneID" id="24564984"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303470"/>
    <dbReference type="OMA" id="TELKCYE"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="9">
        <location>
            <begin position="326"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="430" mass="46662" checksum="A037DC4A4D9068CD" modified="2014-09-03" version="1">MEATEVQGDRKIPVTLVTGFLGSGKTTFIQRLLKERHGMRIAVLQNEFSPEMGIEKPVLSAGGASVFELPNGCLCCSMKDGIVEAVESILQFRCDFDWLVVEAAGNVDPLELASNFWLDPESPLLLDGVLSVTCPAVIQAVLSGANNNAAPSPNNRKIKDGDIEAPKLLEECTAAPIRGTDDAGAPTRPSGDRRFKLLGNETLDDKNMLNLMRKQLSVADVIIINKIDELDCHFGDGHQSGAEASAAQMQNGGSGSISSVFADFTSMLKDMNPTAKVLKTSFCNVDFESVMNLQMFAASRIMTFLSEGHHDHHHPRNGDHSSSNVFIKSQGVYSLDYVNTFVSHLLWESGATVYRCKGIFKARKDCPMVTDADGATSVFQLQGVGMLFEISETEVADLDDNRFLFIGPGIDADKIRNALQLPPDTASENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7E9</accession>
    <name>A0A061D7E9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT, Winged Helix DNA-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766985.1">
        <property type="nucleotide sequence ID" value="XM_012911531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7E9"/>
    <dbReference type="STRING" id="5866.A0A061D7E9"/>
    <dbReference type="GeneID" id="24563340"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110970"/>
    <dbReference type="OMA" id="FMELQDE"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="416" mass="46501" checksum="4A958F3841DC06D5" modified="2014-09-03" version="1">MATDPPVKGGVGSIMVNTTRKAYDKETFAALVESCTRLFCCDEEIVIADLLLAVERAITERDIESELGLPERKVHEFLVKLERHGLVSRVTTGQTTDILAKPVRQPRSSRDILPPPPQSNAQTFWRLSSYFILAVHYKLSKMEEMLMQRRRSLHECDRFVCPSCNAIYDSLEVQKLEMDGFDAHFICYCGSKVELDDKATKDSIYSSQQQRCEEQVRNLKKCLAAAWGMEVPQFAVYIRGKEKIVNKEEDGAAQDSAAISTVGGASSVVSGTSDTSESLTAAPAKPIVKSLLAEVTRHTTTTLSSNGKTSKIKFRMHHTLKQETATTNQVTLATKLLNEASSGTQADAKSQDSAPAEQANVVEESEQMEKAEDITFYITKLGRSFPLTEAQDYQQHMNNEEFENFLELQDRYLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K2</accession>
    <name>A0A061D7K2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family M3 containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0304270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768709.1">
        <property type="nucleotide sequence ID" value="XM_012913255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7K2"/>
    <dbReference type="STRING" id="5866.A0A061D7K2"/>
    <dbReference type="GeneID" id="24565064"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304270"/>
    <dbReference type="OMA" id="ALMFEYM"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="94"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="289"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="597" mass="66679" checksum="52CF543B8DAE0261" modified="2014-09-03" version="1">MMLQMYDIMTNAYAKYGAHISKEESLVFNHMIESMRHQGVGLQSSAKTEYLELQSAESALSYELSDSSTLKHAAIPSIHGRPLPRNPAIYSYILRHSPEEQVRRMIWEAQTKCDPGTLSKLLRLHSIRSRISQIRGFRNFAQCAQRECILNEPEAVETFLRKSASSLRQRLCSELQELLDLKRSQGSADASLQPWDLDYLIGAERDKLGIQLRVSSVITYFERLLHDLFGISLVRDTSEPLWHPLVAKFLLVKYAGVGTDTAFEGSGRSDTNENIAAKNNHFGGKQVEVAHLYLDLFARDGKASVCAQFTVRCSKLLGHRNGEKKGTSHFPSAVSGLRMTHGYQYVTKECTDGSIRQLPATAVVCSFPTDPQHADISSALNGTYIDAHSAQTLFHELGHTVHALCSRTGLQHLSGNRGGVDFAEFSSHLFELYFLDGIRDICKIEGLDSESAKKAELSFSKYSAIETGRMTLLALLDLKFYTFKGELTVAGIDDLYKSVDIFDEEFGSSKVSRLLGLPALSNFDHLIPYGGTYFCYLYSRVLAIKVWRSFEGFSRSRATGDRLYAFFEKGSTDASIAPLNELAGRDLAAMEDELFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8B6</accession>
    <name>A0A061D8B6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767345.1">
        <property type="nucleotide sequence ID" value="XM_012911891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8B6"/>
    <dbReference type="GeneID" id="24563700"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203160"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9173" checksum="02258E9F23A64775" modified="2014-09-03" version="1">MDEIICHAIAAIVGANLGTSLRRTNRCMRRNEAQIIQIRHLGNPSPPQDSVPRMNDCSTELQYTGSLYIKVVKYVPYLTDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8E3</accession>
    <name>A0A061D8E3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0203410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767370.1">
        <property type="nucleotide sequence ID" value="XM_012911916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8E3"/>
    <dbReference type="STRING" id="5866.A0A061D8E3"/>
    <dbReference type="GeneID" id="24563725"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203410"/>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="549" mass="61213" checksum="9129726C41198E5E" modified="2014-09-03" version="1">MTASEDGSVWHGFPKSHLLRTVMQLLLDMGYRDTVKTLERESSCTYQCPRVTELEEAVRIGDMTNARSILSQLKLPPEIRSACSFLCSQQDFAMALHRQEFDEALRVLREELCPSAFDEDTQRRVQKCASLLSYPSPDDALRSEIHWDASSSLGDLWLRLRHLISPELCVPPNRLLTLLRQAVELQELYCPHHASSLDEPGPPSLYEDHTCPEVAPPAQCVARLEGHSDEVWDIVLSPNGQYILTGGKDESVILWSASEPFDRIHQWNDHQAVVSSVSWSSDSELCASIDKDGVILLWSPHYAWCIGGVDPSDGVQLCISWVPGRHAFLASNAERQVVLYEVEKPFGNEGAAASDPTSPDESTGEPSGSSELRYTVKAARRFTVNCRIRTIAVNKDGTLAIGASPDRLTHLIDIATFRELPPLPEHSNVTMVACSALHNQVLLSVAGRYPVIRLWDLDERRVIQTYRGHREDRFILRCAFGGPDERFVVNGSEDAHIYIWNKLFGTLVAVLQAHSSTVNGIAWSTRPGGYLFSVSDDHTVAVWQPLPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F0</accession>
    <name>A0A061D8F0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768438.1">
        <property type="nucleotide sequence ID" value="XM_012912984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8F0"/>
    <dbReference type="GeneID" id="24564793"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301560"/>
    <dbReference type="OMA" id="LMSAPMM"/>
    <dbReference type="OrthoDB" id="361066at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="10165" checksum="AF0ECEF16AF9B97E" modified="2014-09-03" version="1">MRCLGGSEIHRIAATVARARLFSSSRPYNPNVVNECVNPKPGRPFKVMRLLGGFGCFMLATPLILMHFDTKRFEAELERRRQEEAARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G1</accession>
    <name>A0A061D8G1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767390.1">
        <property type="nucleotide sequence ID" value="XM_012911936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8G1"/>
    <dbReference type="STRING" id="5866.A0A061D8G1"/>
    <dbReference type="GeneID" id="24563745"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203610"/>
    <dbReference type="OMA" id="VTSYKHY"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="383" mass="43791" checksum="FDE7890CF21985E2" modified="2014-09-03" version="1">MKQRVAKKGGRGKASTSTKKNDYRNKKSRNVKAQSHHDDDDLSDVEAEYLEDIPEAIAKQIHQLANENDRESRKVALANDAEFLEQDALISDTLKDISGFMPEKDVPNSSVEIGQLSKVLFKSASQEDEQLSKIRELYTSIGVYLSKFKSGNLPKAFKVLPNFENWEELVGLTCPENWTPNAMYLVTHIFASNMTDSKVEIFYNKILLPTIRKDIRNGKKLNYHLYMALKKAVFKPVAWFKGIIVPMVEEGCSYKEAAIIGNVLRRISIPVLHASAFILRLCQCQKWFGSSSFIMSILLQKGYNLPKKVVEECVRYFCKFEGFEDQLPVIWHQSLLTLVTSYKHYFSTEDYARIQKLIRVHAHAQITPVISHLLSCTVNEVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H2</accession>
    <name>A0A061D8H2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leu/Phe-tRNA protein transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766231.1">
        <property type="nucleotide sequence ID" value="XM_012910777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H2"/>
    <dbReference type="GeneID" id="24562586"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103590"/>
    <dbReference type="OMA" id="MGAKCIS"/>
    <dbReference type="OrthoDB" id="2122564at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="entry name" value="Leucyl/phenylalanyl-tRNA-protein transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="LEUCYL/PHENYLALANYL-TRNA--PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098:SF2">
        <property type="entry name" value="LEUCYL_PHENYLALANYL-TRNA--PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="495" mass="56584" checksum="AEAE011113F18C99" modified="2014-09-03" version="1">MEGRPFEGGSVGGRCTGCGGSCPWELEEQANLEWDRRLAEMLSWDIVRPSSASFDSRHPPAITAEYLEHCSCFAISLHTERWRRLVSTIKDANEARKGMTVDDSVEELLKLEVLLFTDHNVECRRQLARGLLVQVWRDRRPTKAPWYSKLMQLVRDLDALCFLHRLHGAQRMVSVGPMVTPYSYLNSVIAIFRHEGLEGETVWSPYIEGELMYRLSGRGFLTIAISVDALKYTKRLLVPKMHTDRCFMRPTWIRMTRRAKRLAKGLRVTLDTAFHQALVAFAGRTSNHLEFCFGSQLQSFAYWQCQAVIDAIVQQHGANWMYPEVCTEFNRMHYQRHRFGSVDTRLHSVEVWRGDELIAGEIGCTLNALHRYIVSVSAGAVYTSLTGFHLLDSSGTFQMYALAAILHFSDVELWDLGMEIPYKCSLGGTTMPRIKFIEEFHRLKQIVGFSLLVDTPQERHVHLPSRFRENENCVSLLEEFEAAQQRVGMEGSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J7</accession>
    <name>A0A061D8J7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766256.1">
        <property type="nucleotide sequence ID" value="XM_012910802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J7"/>
    <dbReference type="GeneID" id="24562611"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103835"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103835"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="99" mass="11447" checksum="DCD87ACD9D0C6240" modified="2014-09-03" version="1">MQILIKTLTGQRVPFDFEPCDTVAQVKRILQESERRRNILRDTHRMQRASNCSRYGSSTPVSAVASRHLTAPQADTSRTSSRSRTTRSRPALRYTWFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L0</accession>
    <name>A0A061D8L0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766271.1">
        <property type="nucleotide sequence ID" value="XM_012910817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L0"/>
    <dbReference type="GeneID" id="24562626"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103950"/>
    <dbReference type="OMA" id="CEYCEDK"/>
    <dbReference type="OrthoDB" id="365094at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="918" mass="101929" checksum="959F3AD2B2398B6C" modified="2014-09-03" version="1">MVASAVLPMLYEFLVSESRYEVRGSEYRSRLRSLFEEMLSAQLSYPPFPLIGWRQPCFKPLEDMVNSVGFADCEDVRVLKLAACPGIRQYAYPEIPAYARLDPQYLKQWNFFFGVFDKRERVATPNRPRRIRAGESSGTSSSCTESEEEDSFSESEDSVTLEHLDAVITTDDILRPRVRPDDAKLFRSDSGRSSGVDEGSVHDSTSRWGRHVPIYMDSSYKIERGVIVFGVINDAHLSYEWSCNGSYNAYESALQRFTEDNIGAPAYNVAAEGFSIDDCTDGSLNCDTQAATDYMAMEVDAPDQPGPANEDTASREDNANSLSIGATCEDLNKAAEAPAPATEGALQPACNDNADVVAKNVEEATVDALDDDRTMTYDGDDDEDASEGPCDGDSGVDGGETAEDDSYLPGTYDPKSIYGNYYCALPQGHNSSQLTLDGGDLGAASERASAEYKSYTQDAMEIMSTVIVGADGVPQLSCVGTLGERDGNTQDPRLKKYHNRQVTLQNRLEDAISSVFAIKNAVSAECTTCSGWSLNNGISVIFCEFCEDRMLEEFDPSVINRLFELRRLLVSDLYPAIGYSFVDPDASKTPKGEGCASYVTIPALCEVGGTYPKASLRDGRCVPNTADIPAKALRELSSIVMTNAELSPYSESGSRILNLCVDRRRQRLRAFNDYLEALCKLYETAVSNKHYPIVVEEFNNVFKKGMMPFMSISLNNKSRFFDEATSSLFCRMPLDVDMLRRLFYRRGIYGDREGSRGTNLLTLAEQDGYRLRTTSHTFVYNWHMVAFKFWSRKSSTVERPCKTEPTKPASHTSRSSLYKEFVSRAGTWDRLPREVVTHLQSHGKLDVGFPTSLEMHVAGVPDAVLDPLLFMKCGMSFFYSLPAIIQNMCALSQHIRVCEETDGRTKRRARENAAGKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S3</accession>
    <name>A0A061D8S3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766331.1">
        <property type="nucleotide sequence ID" value="XM_012910877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8S3"/>
    <dbReference type="STRING" id="5866.A0A061D8S3"/>
    <dbReference type="GeneID" id="24562686"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104540"/>
    <dbReference type="OMA" id="MPMIYYK"/>
    <dbReference type="OrthoDB" id="299781at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="239" mass="27275" checksum="61900DC4C7301F81" modified="2014-09-03" version="1">MPEEKIEATGIPLFRLTLIGAHGVGKTCLVNSIMNNVPPPSYKATRIPELYYFLLRLSYDEPIVKDAYDDINAFCFEIEDTCADDDVRQLIDMTRAKWPFESGMNDYTPFGIFKEPLVPMRKGDELRPVSQNRMAFLVVFDVSNYESYKYAISIVEYIMHNLGSIGTTQPLVCLVANKSDLMRDDAPIWDEAETFSQARTVPMYRVSTVLNQNIAKMMRELAMLLYGSLALWEIVTHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8T9</accession>
    <name>A0A061D8T9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery associated TMA7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768563.1">
        <property type="nucleotide sequence ID" value="XM_012913109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8T9"/>
    <dbReference type="GeneID" id="24564918"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302810"/>
    <dbReference type="OMA" id="HDLEFQE"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="6303" checksum="DBE0833B6E300ADA" modified="2014-09-03" version="1">MPAGTQGGKKKPLKAPKKVVVETEEDVEFKKKQAEEKKQLEAARKELLQKQAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D915</accession>
    <name>A0A061D915_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769377.1">
        <property type="nucleotide sequence ID" value="XM_012913923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D915"/>
    <dbReference type="GeneID" id="24565732"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310940"/>
    <dbReference type="OMA" id="VCVAMIF"/>
    <dbReference type="OrthoDB" id="347622at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595927" evidence="1">
        <location>
            <begin position="24"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="434" mass="49428" checksum="82DEE5FE704C22BA" modified="2014-09-03" version="1">MTVAWLPCVCLMLCLAVIDRSLAFRVTHGFASARRIPGRLRSDHIDEMMFECAIYNSNLRFPRNVDSELNPHAARDSATQSRLESMSLELTKQQLETFKRRKEHMRISLPISGEVSRPRGGHLQKLYYILEEHNRELMENELYRAGTEGGEQNTVDIDNLRKIVLPTQMYRIFDSPSVTKRYRLFPTTIKSHSPVVPGQLSTITLQEPHRELLVEQVRSSNVFGIPVAFLEPSKFDNVDPEISPHACMCEFVDLTDFDTTGKIVVRATQRLSIVDMPATKDPIVLADVSILEDERERLRNPNLTQGNARAVAKLYDKCNEQEAQLSRLEGRMGDVEIVESRELFADKLGRMIRDVPLDGDHEYRILELTGFAAMEFHADTETRMWAANTRDTEERLACAKTVLEEKSAYLKGRISEVKRNADPPIAVNVSDVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D931</accession>
    <name>A0A061D931_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767590.1">
        <property type="nucleotide sequence ID" value="XM_012912136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D931"/>
    <dbReference type="GeneID" id="24563945"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205620"/>
    <dbReference type="OMA" id="EPFNPLN"/>
    <dbReference type="OrthoDB" id="366365at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="22052" checksum="C33E5552301247B1" modified="2014-09-03" version="1">MATEKRDSFTDAERAAFEWSRNRNRSGRDQRRSRSRSRRRSYSRIRSDSSSDSDHPKDPFNPLKLAYDRRGRHRRSRSPYGRARRRSTSQPTNSPDTWIHDLYYNDEGRAVEDARYQRGRREQDSTSYKLDTRRGSWRSKAGGVYIPPDEAASVNDDLYSDYKPTSSRNTARRSPSYERPDPVYTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D950</accession>
    <name>A0A061D950_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769407.1">
        <property type="nucleotide sequence ID" value="XM_012913953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D950"/>
    <dbReference type="GeneID" id="24565762"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311240"/>
    <dbReference type="OMA" id="VENIGRW"/>
    <dbReference type="OrthoDB" id="364389at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1179" mass="132164" checksum="2A9D07CCF2C3490A" modified="2014-09-03" version="1">MKHGSESKIGEELDRFLLPTGPSAQVTEAIQSFHDGRSSWKECCDQLRTVERYGVHGVDGGRRMFCAVTLKHHAYHGLRRLCPADKSPTRDMRDSALDDLVKLCWIYERHDKLILRQLLYAVSGLVITFFDIGANERDFLLNTALLRFDSRPLIQFELLSAFAEELFNENIGVSSFTRADVVRSSVMIAPRIFGRLFAFMGDKANIEHVPSLRALAHWMGLHVRLVRTFGGTHEYVPNEAHGGIHTFDMDAMGAKIPRDDAVLIRNGLNAFGAMGGVFSLFERLRHSILVKHVEMSSLVCEALIHFYSLTQFDFMNILTATSQRYNDVSSHTSRSWTTSSKPYIAQLPCIVTDSCNWAMDFVSQLQEILCPLMSQCRDNPADPRFPVVTQILRNVMEFLVVIAAEHIPFILMFSEGEMHKACAVCFFVNEAVRYPDMHCRELCLDFYVSMISILFATKDAMAEPHLSTCVLRIVQAMRHNYTDFVRQLLKSATLDFDNHEEEAFDNYRRLIAAFIDEAIHIIGVNVLVMVIQCKVKALEEGFDWVEAEMCSFLIRAVAHRLTPGLAEAIILKYLSIVCDEKRFRELYAEKGDDIASYVHRSIALCIVLTSGLIVQDAEVLKAAQQLCMNNFGSGNGVYPSFSARAMHALALSADYSTCDVFDLMRNISQKIAQADSPLPSRLELLGGIANLLSTFNDSAKVRLRRDFVAAMSMRLNGLIDAGQTENMADEIALYVSTLFLVDFKPWFTTDVGGNLSKECMDLMRRNHESTTLRRIKRINAFWPQVDLCLESLRVDQRYPTDDVENVTRLLIWILKEAHFGSHSHILALYAALHSTRLCKQEKLLNKCMDVADQYVSRILNVMIDCDDFADSSAPAVSGVVTSDNEVIKAEYSASSESVVKLFHPNSVEVNGVHSHATSTDGTPSQSLRIDEFTRNAYGHGSYTDGFRSVGHRAEDRDVRNGFNGPYTEGSRATGNHTSGSRHVDLPTGAASDGSAASHFRQSATEILRILNTERFRAEGDLNSLDLFTNAIRSGVSNHVSALRLLTWPKFGRYVAVVALLLPTENPALNRSIVELFVALVHWIRRTRTELPDKERQKRRLIRNAARAILLGKHFAQSNMTMADVVASSIFQSMMSRPCQVEGCIPPATRVIHTLIGSKSFYPMVAASVKSCMKVGFATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D961</accession>
    <name>A0A061D961_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769269.1">
        <property type="nucleotide sequence ID" value="XM_012913815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D961"/>
    <dbReference type="STRING" id="5866.A0A061D961"/>
    <dbReference type="GeneID" id="24565624"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309860"/>
    <dbReference type="OMA" id="KREIGCH"/>
    <dbReference type="OrthoDB" id="338859at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="182"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="559" mass="62865" checksum="6792594C7A1C3F28" modified="2014-09-03" version="1">MECAEYEVSEVSRVGWPGDDKVDLRGNSLSIPAFPALCKRRSYMRNSRDVCAHKCKSSNLTPSLVCRVRKARDNIADQCTDDCYNGPNGSSSMAVDLKVGFGARSNGSCGGYRGPSKGGIGGSASPLLCGAHKCSDIPCNNVRVSPDAQWPPSSIGVLHDLDNYVEINFADYRPLYNRIGPVMFRTSLLEGLYSPAAELRLTPELRSLLISQNSTQRVVYNAFWLPKQFPKIALKVAVKSVRDCNMRDGRSIKREIGCHLFIYQKLVGASRDACRSSPIATDDWPTSEVLGYYLDKKNPGVSVLITRKLFGPDFFDIIRSECSPRFASRNTPLYELNKLDWCIIAMERVAQLSELGIRHNDLKPDNIVLDMYESGGVKRVDVKVIDLGAASMEHTKEFTGGTSWYESPEQKLLEYYTKKHHNSKRARTVDINRASDAWGLGQSVIEVLLGRRMVDHMRPPFGSGPPELIDPPQEVTEENTDRLWWDRDEYWTIPPRVWLQHIRSVLQMDSATQKFPICAQAARYVFDRLMQVDPQQRASVRSVAEGLRHLAKCEIAKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D996</accession>
    <name>A0A061D996_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769447.1">
        <property type="nucleotide sequence ID" value="XM_012913993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D996"/>
    <dbReference type="STRING" id="5866.A0A061D996"/>
    <dbReference type="GeneID" id="24565802"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311640"/>
    <dbReference type="OMA" id="KFNERTD"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="547" mass="62299" checksum="C6C53511E25F842A" modified="2014-09-03" version="1">MATIRALFARSRALRSAAGGSGSSTQTWLNLGAFATGGDAKQEACWTDLKNAELAVSNTVEAAQRQPDVVDWDRWEGLIAHKDILRHMKQTYDANIAMIEKAAAAEGDSSHLESHWELYEAARQNCKQATRTVNKIVADGSKALWLSQNNPPVWKVDTNEWLESDQYWQAFVEKHGMYSQSGDAPDPEAPAVVEANKASWNSRMVKFNERTDTPMLYEYMHHLPAWEYYDINRKQFFEHMSYFLLRTGDDFRHFPDLPPWQWLTHLEDQRFKEFAVTQRRREKRQLERVARFEPDDFGTGEEHTGEETHMAMLTSEKHAAEQTLANLMGNFCFLCDPLVPVQSRFQLQYILSKCGHDKNGGARVLSLGDDVNALFVLPAGAAVDAPMASPLECFHNMMEHYRILGMRINPSYATRVENQVELIHQRGPNWLKLKNETVLESYLRRMRRDDPLRADFEDYAQQLRERIAGAKELPPEEWERAIASVEERAMEDALAVRKMEGAKHDKNAHKLAEMDLQQLIDDGHLLVVDPATGATVTNAGEVAAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A5</accession>
    <name>A0A061D9A5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0310310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769314.1">
        <property type="nucleotide sequence ID" value="XM_012913860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A5"/>
    <dbReference type="STRING" id="5866.A0A061D9A5"/>
    <dbReference type="GeneID" id="24565669"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310310"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="188" mass="21575" checksum="2B70F53349DED59D" modified="2014-09-03" version="1">MVKRSDAKRKPSLSQNLTHYHVVGRAAPSKKNPNPLIYRMNIFAKNAVLAKGRFWYFMRKLQKAKRSGGEILACNVLLEPKPTKVKNYGVLLRYECRTGIHNMYKEYRDTTLTGAISQMYGEMAGRDKARASCIQIIRAREIADADCRKVRTTQLHNTKLKFPILRPQPLVTKADRETFADHRPSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C0</accession>
    <name>A0A061D9C0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768773.1">
        <property type="nucleotide sequence ID" value="XM_012913319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9C0"/>
    <dbReference type="GeneID" id="24565128"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304900"/>
    <dbReference type="OMA" id="VCKAHTP"/>
    <dbReference type="OrthoDB" id="360445at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="80" mass="9482" checksum="7AFEDB3B0812535F" modified="2014-09-03" version="1">MVVPAHWFFKLSIAKDRVRFLRLYATFGLGVGLLIGLSAHHPKYTSEPFKPSMLYRLHLKRLLWSGKITQEQHDKYLHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I4</accession>
    <name>A0A061D9I4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DNA repair helicase (Rad3) family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0312290</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769512.1">
        <property type="nucleotide sequence ID" value="XM_012914058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9I4"/>
    <dbReference type="STRING" id="5866.A0A061D9I4"/>
    <dbReference type="GeneID" id="24565867"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312290"/>
    <dbReference type="OMA" id="NCATIVA"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="12"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="471"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR97326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="951" mass="103899" checksum="AE898A899CD33680" modified="2014-09-03" version="1">MAPSGEYVHIIDGIDVRFPYQPYPCQTVYMETVIKAVKNGQNALLESPTGTGKTLALMCSSLACLWHSRFKDASAFKLNSLDGSCEASLLSTISDLRSSLQGGPKGPKGKASNSLRIIYASRTHSQLKQVIREAKKSSYTKEFAAKGLTTIVLGSRDQLCIHAGRRNATGEALNNFCRKLVQGQGCVYYNGLKKYKGNSKLQFYDFIDIEDLVMLGKSQKCCPFYASREAHETADVTLLPYNYLLSPRSREAMEIKLSNSVLIIDEAHNVESVAEAAATFAVRQVDIARYLMALRRFAAAHKKAIDAQDPAAQLEGPAIDFSAMAKLAVALKNFDAFLTNLKLGTYSKDSPTSQSMGLDLWQLATIKREHAVVKGVDVLQYLMKKIGLYELRNMKIDEVIKSCISVLSTNVDDISYAYQAYYDNAKTLQEDLQALTGLMLFFQHVYSKELLACPEYFHVFVTHDTSFGAHKQQEAASASPDKSGTAGGGWKSKGLQRGGDETPGSAPAEEGPLPKIMTFECLQATPSFLRLKNDGVRSILLTSGTLSPLSDLEKNIGDDKISFEYKLSNKHVAPASHVCARVITGTAGDPQILSSAFNTRSTPAYIKALGESLLTFAKCVPAGVLVFFGSYPVMESTVKAWKRTGIYSHLEKEKTIFVEARGASSAASAIVDNKFTHGGADPTQAQLKEYNDLVSKGRGCVFIGVCRGKIAEGIDFSDDACRGVFICGVPYPNPYEDNVALKMDYLSKGAERGKGEEVMSLWYNSQAIRAVNQAVGRSLRHIKDYGAVVLADRRYALSNLRKGISGWVTRNMEISDTMASCELDLRNFFGQFAREPSTPTPRGSSVHILPRFFTSITDSLSPSKRSEDADSDLLRFKSRRICSDDGTGIASSLRSGSQVTAFANGFMTNPTVIAKTQPPAPKDAAAPPSGWDLLNSWSNGDSITLTKFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L4</accession>
    <name>A0A061D9L4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769552.1">
        <property type="nucleotide sequence ID" value="XM_012914098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L4"/>
    <dbReference type="GeneID" id="24565907"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312690"/>
    <dbReference type="OrthoDB" id="365638at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="134" mass="15534" checksum="0033794BF01F0886" modified="2014-09-03" version="1">MLTSLHPLSRPIAGPRCRAYEMQRRRVTTNRNDRPGTEWRRRVVGCQPLQNLKVGPYKRGKWFVSYKDDPGSFITNILILLVTGYSIFTMLPGESMSVRRQRKMRQLLLDNAQMTEADLAYIENYRLPEDGDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9P9</accession>
    <name>A0A061D9P9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Carbamoyl phosphate synthase pyrimidine-specific large chain</fullName>
            <ecNumber evidence="15">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BBBOND_0311560</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of the biosynthetic pathway leading to pyrimidine nucleotides. The large subunit (synthetase) binds the substrates ammonia (free or transferred from glutamine from the small subunit), hydrogencarbonate and ATP and carries out an ATP-coupled ligase reaction, activating hydrogencarbonate by forming carboxy phosphate which reacts with ammonia to form carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="15"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769439.1">
        <property type="nucleotide sequence ID" value="XM_012913985.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D9P9"/>
    <dbReference type="GeneID" id="24565794"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311560"/>
    <dbReference type="OMA" id="WSPFNGK"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000051">
        <property type="entry name" value="Carbamoyl phosphate synthetase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="619"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="1212"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="1469"/>
            <end position="1656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDR97253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1656" mass="181284" checksum="9A48A001023C8D2B" modified="2014-09-03" version="1">MGHDSDSSEHVWYPEELRRGPPAKLLLKDGTEYCGYSFGYVDESYNYVDPGSVDTTGEIVFSTAMVGYAEALTDPSFLGQILVMTYPSLGNTGVPPTEQDEFGYLKWFESSKIHVRGFVCCDYSVHDSHWSSCKSLSAWLREERIPAIAGIDTRALTKHLRTCGSMLGRIIIGRAATLPADSRLLSNSAFYDTNSVNLLETLPLSPPTLYTMREVDGHKYVSKFEFTAAELKEILQRDPGAFHVADAMSAFAPKLKYDGYPKSPVQPHSPAGSCGAQGSGELSNCLGLKDVTLVVVVNCGAKSNIIRLMLRMCPPQMRLLLVPFSFDFARIPYDGLVISNGPGDPNEAHSTIANLRLAMQRTAPIFGICLGHQLMAIAAGASTYKMTYGHRGFNQPCVDLRTSKCYMTSQNHGFAVDEDTIPPDWSTLFVNANDGCVEGLIHMVNPWFSSQFHPEASGGPTDTTFLMLDFIYSMGKNGCIPLHIRAITPRVQWKRILLLSSGGISIGQAGEFDYSGSQAIKALKESGADVILVNPNVATVQTSYGLADVIYFQPITFEFVSEIIAKERPDGIMCSFGGQTALNCGIELFKSGILAKYNCEVLGTPIETIINTEDRAIFNEKMAEIGERCAPSKVGTSADSCVAAAAELGYPVLVRTNFALGGFGSGFAKDEAELREILSNIFTAGSCRNGHEPAEGTASPNQADVGPGSVSEDSTVCVYIDKALNGWKEIEFEIIRDSNDNCITPASMENFNPLGIHTGDSIVVAPAQTLTNVELYKYREIAFKIVRHLGIIGECNIQFAVNPDSDEYFIVELNARLSRSSALASKATGYPLAYVAARIALGFDLVQMRNAITLVTTACFEPSLDYVVVKIPKWDLRKFEFADNLLGSSMKSVGEVMSIGRTFEEAMQKALRMSGDGVTGFSSGVLSTADRDAVVHGLCHPTPDHVSAIARAFELGMSVSEVHGLTRIDPWFLHRLHYLHVLTSHLGRFSSVSELSFNQMRCYKVHGFSDKQIAEGLGDASATEDDVRVHRKSLGVIPVTKVIDTLAAEYPAKTNYCYLTYNGIENDVSACSPADVARSSCDDGDCTGKSSGPAIVVLGCGPYRIGSSIEFDWSAVSCVKALRSLGYRAVIVNCNPETVSTDYDVSDRLYFEELTCEIVDAIYQFERPMGIVISVGGQTANNLACKLHSLGLSILGTSVESIDRCENRNKFSKLCDVLGIDQPSWEEFTSLEAAEQFCTKVSFPVLVRPSYVLSGASMRVIVSFDDLKSFLQTSAVINREHPVVISKFIENAKEVEVDCVASQGIILNYAISEHVEYAGTHSGDATLILPAQNILVGTHRRVKKITQKLSRYLNISGPFNVQYLCKNNQIKIIECNLRASRTLPFISKTLNMNFIDQATRVMVGSPARVQNIQLMDIDYVAVKVPMFSFDRLYPSDPLVGVDMKSTGEVVGFGESKYEALMKAMISSGMRIPSRSILISFGTDVDKFLISRKVETMLELGFNVYATEGTYNFLSRMNEVSTSEGGMSGRLDVRSLLSSNLVFFEDTITDGWSRNADQRPRGKLLPAYKPSDGREPSAVSLMKSGEVDMFINVAGRVNPGRTSDGYIMRRAAVDNKVTLITSNKLALLVIDALVMRHIRSSKGKVFFHNKSHQEYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9S9</accession>
    <name>A0A061D9S9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766676.1">
        <property type="nucleotide sequence ID" value="XM_012911222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9S9"/>
    <dbReference type="GeneID" id="24563031"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107880"/>
    <dbReference type="OMA" id="KITRHDA"/>
    <dbReference type="OrthoDB" id="364968at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="81" mass="9393" checksum="EBF44CF9009FCCBD" modified="2014-09-03" version="1">MSCKKFMVFLGSSAFLGYAFVTYRLKLTRREALKRFEESEDGRRLAMESLSFAPKIQTEGPDVSQKLIEEYKARQQPPIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA49</accession>
    <name>A0A061DA49_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYG1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769594.1">
        <property type="nucleotide sequence ID" value="XM_012914140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA49"/>
    <dbReference type="STRING" id="5866.A0A061DA49"/>
    <dbReference type="GeneID" id="24565949"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313110"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="322" mass="36575" checksum="B84C872EC0872FE4" modified="2014-09-03" version="1">MKIGTHSGNFHCDEALAISILKLLPECKDATVVRTRDPDVLSTCSVVVDVGGVYDPSKGRFDHHQGSFDEYFDENHRVTRLSSAGLVYKHFAKRVFKEVYGVTDEANLNDIYLHVYDNLIQSIDAVDTGVPIADGNLRYEVNTSLPSRVGRLNPSWVETHVDVNKRFEQAMQITLEEFDYFVRNFIDVHLTAKTVFLQVYQKRFETHPSGLVIETPRGMPFFGRLYHLEEKENIPTDQRVAFYVNYEAATGQWRCSCVSERGQQFTCRRPFPERLAGLTNAELENASGIKGLTFIHRGRFTCGGLTKEAVLSLITLTLQEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA55</accession>
    <name>A0A061DA55_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0307310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769013.1">
        <property type="nucleotide sequence ID" value="XM_012913559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA55"/>
    <dbReference type="GeneID" id="24565368"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307310"/>
    <dbReference type="OMA" id="PTLVFCC"/>
    <dbReference type="OrthoDB" id="360604at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="118" mass="13605" checksum="DD421DD2D4AC8A0F" modified="2014-09-03" version="1">MKFSSATLQRRVLSAGRSAADCLEEFRRLAAEQSRCRLTFEGWPPPSRLQIGDGTLAPLGRDIFVFRRALKDGLRSEPTLVLCCAGRPMLMLRRSEFEALVQRLQWIKDQMKEFYKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD8</accession>
    <name>A0A061DAD8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766881.1">
        <property type="nucleotide sequence ID" value="XM_012911427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD8"/>
    <dbReference type="GeneID" id="24563236"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109930"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="95" mass="10682" checksum="08A11F6CBDC2BAE0" modified="2014-09-03" version="1">MDLGTGVLVARKTGLEALIHEVNWRPRRRLRKLERSDVRLSPHHLQCATVPERLDAAGQIGVYTGVRGIRVHNMSLGDLFGRVSDGFRDSKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAJ5</accession>
    <name>A0A061DAJ5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769759.1">
        <property type="nucleotide sequence ID" value="XM_012914305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAJ5"/>
    <dbReference type="STRING" id="5866.A0A061DAJ5"/>
    <dbReference type="GeneID" id="24566114"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400650"/>
    <dbReference type="OMA" id="AMVEQDM"/>
    <dbReference type="OrthoDB" id="361505at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="496"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="541" mass="61577" checksum="14FD7A1F63F7D904" modified="2014-09-03" version="1">MSKTKRSRKDANRGAHPGDASNNLFDTVRRSAPAVSVRAPKSRRTKFRSKIAAESAIPQPSHRKALKLDLFNLNKPLNLTHKNEPIENHYEGDVSDSSEDDFHYNGDMGGLSKALEEHKLRKALERQEKDAQRDLLSQLDLEYKNLNLEKYVKQRRGMPQMPALQEKVAVPTKGDQFDANLRQLMLAPQQSKDGGDLLGRLFEAKDANAMCELSKEFVRLGNVSHHTAEKCIVAVARALSELLASPSGHLEFCECFDTLAEFLHYLSQLNPKEYHAYFSTFLKGVYVSFEKEVELSLEVLIVLYFIIKLAKVGSAMYRAVLLVLERVADECNVKDDPHERVRLLIAMAYSTALDSGLYMPFFFSLTMRACVAWSSSRPHLVDPMLDMVRVVLKLLHSKDCHVYPICLHFISPNITELKIQSPKLERLKALVKDYSNVELLPYVLDTASDARLISIQKIELEVPKYGAVSDPYAGRDSGVKREKALYRSLKKGFVQAHNAEAKLRSLELRKRRAQSREKYRNVVRDAMIEQDELRKEFTKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM3</accession>
    <name>A0A061DAM3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0211015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768140.1">
        <property type="nucleotide sequence ID" value="XM_012912686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAM3"/>
    <dbReference type="STRING" id="5866.A0A061DAM3"/>
    <dbReference type="GeneID" id="24564495"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211015"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211015"/>
    <dbReference type="OMA" id="FREVVIM"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000006">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="468" mass="51061" checksum="16095909267F41B4" modified="2014-09-03" version="1">MTEEESRISAAEAAPDAENDAGDAAVVESVCLNCGENGTTRLLLTKIPHFRDVILMSFECGSCGYRDNELQDAAPLQNHGVKITAKMLSPEFLNNQMVLSGHASCRIEELDFEIQPSGQKGYVTTVEGYLSKVSNSLEEHVRSVAEAMANDPNLSIQLSTGEVKTGAEYIHTLATLRERLNDCSEGAEAFTLILDDPSGNSYIEDTDAVELARETYARSEEQQQNMGYAVKDDFRKEIDLTTPMENTDDVGKEGVSLPVDCPHCGSEGLNKICEVCKCIELTWKTCSVVPGFGPCVIMAFTCETCGAKSNEMKPGGGYKDHARRWTLTVQSVDDLNRDVIISETAAVRVNHLDVEMSPGTIGAAFTTVEGLIGKLVESLEKAYPFVLGDSATEEHAPLREKVRELQALVAGDAAFPFTLVIDDPADHSFIGARRQAQGDDANLVSETYERTQEQNDELGLTDMKTEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAN2</accession>
    <name>A0A061DAN2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease P/MRP protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768150.1">
        <property type="nucleotide sequence ID" value="XM_012912696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAN2"/>
    <dbReference type="STRING" id="5866.A0A061DAN2"/>
    <dbReference type="GeneID" id="24564505"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211110"/>
    <dbReference type="OrthoDB" id="366016at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414:SF1">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="159" mass="17728" checksum="13CDF0D243247837" modified="2014-09-03" version="1">MGRRKNRWVLAKVNLQDQTQEAAASARIFTREAFDTEITRICDVLFGSIGGGYVADATNVVLVNETESLVLLQTKRCFLPKVICVLRCLERVQKVPVTVDVLHIGGTLHQCKKLLFSKLLRTLSQLQALTLGQSAPKPAFTHKTLEAIKEVEKLRNPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAT0</accession>
    <name>A0A061DAT0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769849.1">
        <property type="nucleotide sequence ID" value="XM_012914395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAT0"/>
    <dbReference type="GeneID" id="24566204"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401550"/>
    <dbReference type="OMA" id="HDICKTD"/>
    <dbReference type="OrthoDB" id="418962at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="301" mass="35246" checksum="E5F5C31B8B18C804" modified="2014-09-03" version="1">MFIYRLSQNLQFKSPLTAFCRLPPYKHVKSKQWESRCISFWQPVSSAPAKLDSGASNVDLYPKVEGEKSMVTKLWQSIKRVARIEEGDPDEQITEYFQYSVECLMRQPGEFTFDKFATYLEVMQRTSFINVTQEICTKLRLIGKRPIPDEELNGPLRQLKLQRKLAINEMMKFLTPREKESDSATVFSHQAKLLLAESVKVCYTTPADNEMGICPNNSLQCTLKDVDDMLYHHDICKTDRSWYFRRIVLGRHLPMSYEEREHLSYQRPVVREAAQLYPETSSLEALKLKEMRDSIHYRKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB07</accession>
    <name>A0A061DB07_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769358.1">
        <property type="nucleotide sequence ID" value="XM_012913904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB07"/>
    <dbReference type="GeneID" id="24565713"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310750"/>
    <dbReference type="OMA" id="SFHEINI"/>
    <dbReference type="OrthoDB" id="361198at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="516" mass="58708" checksum="2080776E570F2711" modified="2014-09-03" version="1">MAPGSQHHGVEYAMKSDALPEGAQFIARSGGEYFFSNDKIQLAFNEQLKCVREFEFQYRCRMASTYDKALALAARNRLYLVDQAGAVKELKMSKRLLHVHMMGEQELLHVLICRTRKMLQLQIGERTLSLEVYVGKCDCEILFADFVDEGVFCLTYVNEGKDVKIALVAVRNGHLTLLRNDLFRQAKTGKMTRAIGSDKHFLIGCDGKWSVLKYYRLYCAMVLVRHLNIALGSTTTLRLLGQERVMEVEAADHSMKVVYHNVVKGERVEKKIPLQSDCSEILTVDGVGKRVAVLLRAGESGLVLVHFKPPISSRVPVLFNNKLEVHRPEEELSMLIRTGKVAINTQLVDHIMKNKLESCAIECLRSIYIPEKEAVKIIVENTELLKVLIQHTKGDQNEMIAAIRKQVSEEKCAEIVEKLFYMLDNIDMFGDHQIHCYKRIIAFMNILLDAKLFHMQKADKLKPEWVTRLQELVEPCSEENHNLQSLLSFTASLLKSRGKKQKCEKSSLIVSLPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB10</accession>
    <name>A0A061DB10_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767096.1">
        <property type="nucleotide sequence ID" value="XM_012911642.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DB10"/>
    <dbReference type="GeneID" id="24563451"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200670"/>
    <dbReference type="OMA" id="ERSADCA"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1648" mass="183799" checksum="E40A915963B6AC9B" modified="2014-09-03" version="1">MAAKGTSSVAAHGVKLDTLKDCLQFLEWLHDKKQDVARTRVAGRLKRLLDKNYKSVDLHRIEDALSQFLKNVSKFYKTLCDRVEYPKYTPTTTTPALNAVLECISKVLAVMYFLRYRVDAKFDKVGGGGWAQQPVGWVAQLARFDTQMIARLVSSGSEIDAYFIATVDNNTYGVIPGGFTAGELKQLSRGGYNQGSLMVGDLQNICEKHAGSGLQNYFLDVYSTSVIPKTGGTQISNVANALRLVRDFCGIFEKVRDKEDFAKHLYLRDRCIEFQALKDHCANLKVPLGNIFKPEAFSFTGYAREDKDLNIDTFSKKMASWFRKNLNAVKRELANIETFGSKKYPFFNNRTLRSGSGLRQQDKVKLTEYFTQNFFRYGFTFHGYDFTKWRNMYDVLKKDWDGVIEKLNREDDGLDKLVKILNGTMCQLRTEEVEDEEAKEELEIQDEDLSVEEDKPVATKTEAAKPVVTKAEAAKPTVSKTEATKTEAAKPTSTRAQTVENGNEQNQGLKSEEAQHQGKKAEGAQNQGKKGEGAQNQGKKTEGPDQNNGQSEEKFPSSPVAQAVQTHTSSDSSAGSELPGAHASSGGPGPVSQAGSADASQASDRAPQAGVGDSNTSRSQPAAIGGDGVGGGGSSGISNKCPGGKAPIQLWPNSDSKYCPSNVDTNKHEDVYKAWTPEPQITDKGAQYPKNSRITDSYRTTNQSIPHLLGSPRQHTAGPGTGRALYEPGEWRRRQGGRIAETDMPSLDVTGDPIVDSRDHQHDRLLAQRRKNDANRLNIQKLETQQKLAYEDKARIREIEKQKQNAYELWKQKETKGKDQKQYDKFSETLRRQNERNKKVAAELDKILKEGDPQRKKEAEWIKQREKEERRQQEGLRKYLGYLQKHRGDYAPIMGIPIPEPHDFAIDGEAVTTYNDTALKKRMDLSEMDYEKYLNSSRVQLQQRREDLKKRQKEADERYKINAQQIYKIDPKVISDVIIAIDEPNAKGLPGRMPPQVPALYSGTIGEAVEAPESQTKSSSQTPISHIEGHHVSDLSLAPLLIPPLLIGEPLALPPLSTDDFDMIAAKRDHDLRNMPHISGDAIDIPPNSVPTDNTQAVLVESDPSAFEPKGTLNPGFQNGRAVTDSQVSITLDDNIMAELTGVIGNTIKNETNKIPTIEVPDNMNAPISLPAQPIGYSIPNSNRDAPVQEPRPKFKPPDVSGSVTSGFISDVESWTKKEVMYNNIKRDLEAHKQALANDQDRRIKEAQRYGEGFKKMVHMHDDDRNQHLLDDVQESTEKLKFPSPRKLQDIVYPNEKPYVAPPVIETLPHDLQSTETTGDVSKTFIDVNDSESLPEVSLSVDILKHPPFQPLNDYDYGRTFMPLPVVAGGQLASTLDSPRLVSERSIPLFVNPHLCTNPWSVSTSTSSTDTPPTPTSPPPDTDHLPPPRTIREMLFWFVGLNQLGYIGVISEHMKSILKDINKGASQISDGLQVTGDPTELDASMVTAKLTEACLYSATVIYRMKHRDDYSAYKEFKFESVYSNLHYSPDPACLLCQLCDYVYACCHQLEFLKSQCERDKLSGGWQDCKYGSDIKTPSPLHSFLTDGWDSDFETHPFDPCNLCHKSRVRMGFGESDLPKIQQTGTTLSSILTPSCGGEGHDVLRYTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB74</accession>
    <name>A0A061DB74_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770122.1">
        <property type="nucleotide sequence ID" value="XM_012914668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB74"/>
    <dbReference type="GeneID" id="24566477"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404240"/>
    <dbReference type="OMA" id="GICLRIA"/>
    <dbReference type="OrthoDB" id="372835at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="208" mass="23405" checksum="ADC1C2DD3FC430A6" modified="2014-09-03" version="1">MHDRYIHIAQLGCAFQWFARERDVQRDASAETSYGIPKNIATVIREIVWEEDALGIDVRSHLYKEADDPVESAEPRPDPVVPKPISDSGSSSPSDTADSPIENEPEQYVEFDADDSIGSHFAPFTYWKVESGPHVSYTLNPLYSKRRANAITLLEDAEAFVATSIWGNKNTHKMHQAPRHLLVQAAQVASRAFFDPDYRDYLQSSHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBA2</accession>
    <name>A0A061DBA2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768375.1">
        <property type="nucleotide sequence ID" value="XM_012912921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBA2"/>
    <dbReference type="GeneID" id="24564730"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300940"/>
    <dbReference type="OMA" id="SSGARYM"/>
    <dbReference type="OrthoDB" id="365986at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="277" mass="31666" checksum="BAE17B656009ED8C" modified="2014-09-03" version="1">MTRSSGARYMQWPWACVRPILFVRSSASIGLRREVVDTQSPSGSNVLRLTRRFAGSVKEVSPVVQIDSKGSRKFVYDNFGRLRVFFKFLIFQSIPLAIFAYCYRRFEKERQCLYSIPLETVDEALRHLWSITRNAHCFLQVGGKFYIVNYSVGSDAGFRAVDTLEGFVSKFQRDHRDALRNIYVSYPNDRNIDSSIESENNIELLFYNQSLDSFASVKAVAHIITDPGHRKQAWNPKLGPDTNNLAILNTKAVRIGFGNNNNKSIAFENKGDWILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBD7</accession>
    <name>A0A061DBD7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0311850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with ribosomal protein S21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769468.1">
        <property type="nucleotide sequence ID" value="XM_012914014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBD7"/>
    <dbReference type="STRING" id="5866.A0A061DBD7"/>
    <dbReference type="GeneID" id="24565823"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311850"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000012">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="273" mass="30992" checksum="35E8DD5E5B7E255F" modified="2014-09-03" version="1">MVQNTTQAELTPDEDSIRMMLTCKVHIGTKNVENKMKKYVFTRTQEGVHLIDLSWTLKKVKLAARAIVAVTNPAEVVVVSARPYGSRAVLKFSHYVGSQPIAGSWVPGTLTNQITQKFIEPRLMIATDPRTDAQALKESSYVALPVIALCDTDSPLQFVDIAIPCNNKGKKSIALMYWLLAREVLYLRNQIQRHMPWDVMVDTFFWRDAEQLELKFEEQKREEHAASLRPLMPPSVEGDWNQMPGAQANTDWKVMAAGNDEWGNFVDARTTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM0</accession>
    <name>A0A061DBM0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
            <ecNumber evidence="4">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BBBOND_0312350</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EC" id="2.7.11.23" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769518.1">
        <property type="nucleotide sequence ID" value="XM_012914064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM0"/>
    <dbReference type="STRING" id="5866.A0A061DBM0"/>
    <dbReference type="GeneID" id="24565873"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312350"/>
    <dbReference type="OMA" id="KIEHRDL"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="31"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDR97332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="551" mass="60736" checksum="F3C1A9130731AC32" modified="2014-09-03" version="1">MAANRTNFRYSDFKCDLSGACVRFPGIGAYVRIGEKLGCGAYGDVFRGYRLDECSDATPSSNDAGYQCKKRHVGGCSPTSDSAAASAGGDAAGSGKDDGSGLVGTFSNPPETAREEGSPEPHVPDYAIKYFKEDIVHIMNEGFSSGTLRELSIMKSCNDHPNILKLVDVYVGAHPGIAATLNTQLGDMLKSSGSDLSRRKDLHFYPFKNSQVFMLALYEYCEGGDLGRAIWRAYDKGLGGYTLSEVKWYAFQLLNGLAYLHTSKIQHRDLKPNNIMLATSDRLTVLKIGDWGMGREMRNLDGTITPTACTLFYRPIEVILGPMVIPPESENFLRPSQSHRHNYGINADNWSAACIIAELATGQPLFHGNSDFQVLTRIVTTLGRPTEEEWRNCSRSEHYPFKGSLYRMQVTDRKERLRTVLQGRMDDLGLDLLLSLLEYNPHKRLSALEALSHPWFHDVDFRHLDALGVRNCMSNTLMGRFGPGAVRDLEANSGGITSSTLLSHVLFLDSDTRDQVVDAMDRDYACVAPALRQSALPVAIQYSGAARSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM4</accession>
    <name>A0A061DBM4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="11" type="ORF">BBBOND_0405950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770297.1">
        <property type="nucleotide sequence ID" value="XM_012914843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM4"/>
    <dbReference type="STRING" id="5866.A0A061DBM4"/>
    <dbReference type="GeneID" id="24566652"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405950"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR98111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="137" mass="15081" checksum="625F44492D079D56" modified="2014-09-03" version="1">MIPNAATSDNLKSGQESTSVNIVYHSIIAPQLIELKSGETYSGILASCDSFMNVHMVNAICTSKRGDEFWKLDECFIRGNNVKSFRLPEEVADLAVEDAKGTREFSVMYQCDVATARPSTSNSRARGSFFSVINDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT4</accession>
    <name>A0A061DBT4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0313290</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769613.1">
        <property type="nucleotide sequence ID" value="XM_012914159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT4"/>
    <dbReference type="STRING" id="5866.A0A061DBT4"/>
    <dbReference type="GeneID" id="24565968"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313290"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="14">
        <location>
            <begin position="289"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR97427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="601" mass="67376" checksum="789A2CF1CCDB3BDB" modified="2014-09-03" version="1">MPTVSVPKDEFLRRLGGSLTLAELEELCFSFGVEYEECLLDENGVEVIKIEIPANRYDLLCLEGLVTALLAYRWDKPAPTVRYSCQSPRETAYVEALPEPKFTRPYIFAACLRGVKLTQQSYTSLMDLQSKLHQNLCRKRTLAAIGTHDMDRIVEPLVYGLERPEDIVFAPLCDASRDYSAAELVKHYNETNNHLKPYLKILDGLELYPVLRDATGKVCSWPPITNSAYTKVTVDTRNLFIEVTATDRVKGNICLNMLIHCFSQYCADPFTVEPYFTKYSDGLVLSPDLSPRHLDADLAYLRNLIGVPGLTGEDACMYLKRMMIDCEFNPDKGTIEASVPISRPDIQHACDIGEDIAIAFGYNSIAKHSFPMGRLKTVTYMSRAVRDVLFSCGYKETLMPILDSLKTMYERMGWHEPAASSPRRPVLLKNSKISELEACRVSLIPGILRTIANLKGAALPIQVFEVGDVVWRHEGNDVSAMNNTNVACGYANSSTAGLEEVQGVSEILLNELGFYSEYQKWEFGESHTPIPETWKHLYRLEEVDDGAFMPGRAVKLVTSASPSVSLGTMGVVHPDVLRRFHIQLPVTVFELDLSLVKRIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU3</accession>
    <name>A0A061DBU3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770229.1">
        <property type="nucleotide sequence ID" value="XM_012914775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBU3"/>
    <dbReference type="GeneID" id="24566584"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405270"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="96" mass="10475" checksum="090317179425F3EE" modified="2014-09-03" version="1">MKDSQTPYPQLGSSIEEFSFTAQTAGMSSDLVTEHAHVNIMLGHRRKNATALVEIGITNQASLVKAASYVMGKYDDPVKDLKSKAFSEQGCFDVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC21</accession>
    <name>A0A061DC21_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767476.1">
        <property type="nucleotide sequence ID" value="XM_012912022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC21"/>
    <dbReference type="GeneID" id="24563831"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204480"/>
    <dbReference type="OrthoDB" id="381212at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013175581" evidence="2">
        <location>
            <begin position="16"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="22916" checksum="ECC5CE3D1C5AA9BB" modified="2014-09-03" version="1">MIWFCVAVLPALCTAFRIRTAPRATRCSPFALAVSRHDIYRLRRQKEILDAMNFILSRQDKLPIGRHLEPEIVDGMNVIEVALNSDCSHARLKLCITGDSFQQRQGFSWLSKNIKFLRYRLAQLLSHRKNVPTISFEHHNLVQQAGRHGRLGSQNVAEVLMKMNEHVMRRTLRSDSGAADEDKSSGNDSPPPADGRKGFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC45</accession>
    <name>A0A061DC45_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmodium falciparum CPW-WPC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767506.1">
        <property type="nucleotide sequence ID" value="XM_012912052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC45"/>
    <dbReference type="STRING" id="5866.A0A061DC45"/>
    <dbReference type="GeneID" id="24563861"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204780"/>
    <dbReference type="OMA" id="TERKAIW"/>
    <dbReference type="OrthoDB" id="364448at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006387">
        <property type="entry name" value="CPW_WPC_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01492">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09717">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01099">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="100"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="165"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="255" mass="28935" checksum="AB511C128A057B96" modified="2014-09-03" version="1">MLKYTSAIHKQRDESTRLADDSNLEVGDSMGGMASTATMNLDPDDPNILPDAHNIGHNLVNKLEERAVEIADKIAKHRHTESDKEKKEADAKHDQTLFLCQRDYSQPCPLGFKHVATEDGKHKCIFPASYTGPCLGQELVYRLMPEEEKLSWALDCLANWPCVQCTRRYSDLCPEKWELDTQEIATKGLCKAKDEYQGPCKDEKHAFINYNIGMQKQWSHRCQAWWPCDNSSRPGQTPDADMPITMAATAYRMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA4</accession>
    <name>A0A061DCA4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768785.1">
        <property type="nucleotide sequence ID" value="XM_012913331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565140"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305020"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1679"/>
            <end position="1702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1741" mass="196034" checksum="EC396F1F6F3E5999" modified="2014-09-03" version="1">MVPKKLTDCPENLREAIDWLIQVRHGGGGSDGLGELSKALQKLIEEAIEKAYTTNVGALLKILDSAKSYTCCEGKVAEIRKLKDSKNLTPETFENLKSKCEDINNCTKNHLDSSQQKSYDEIESKLEQLKKLGDSLNGFTDERQCKDLLTHLCDGLQTFLGFNPDSKGYDGKGIVYSDLDRLCDGVMGFLYQTMKMIVTDPNVITYYDSSSEYVKILEKHLDNGHHGFSMMVSAMLAWHGYYEKEFSSRVKAIVDNENGKLTALRANIKTNINEVGKLKDLSTKPFEVVVDEWKETVTRGLAISVKNAESAINNLDKPLRNEIMVEFDKIKMQIDKLNESTVRDVKQLNDLARQVNFDLNELKKSVYFAIHTRVGDLRKKLTEDFTAINEEINTVSVTLGQYVEALKVWIQNAQSLVDKAIPQIEAILNEIDDNGSKGRKYPATIKKQAGELKRKADALWSATGEVKRVLKPLGQNIRSAVDTLESVYKKTLKDLQQAVQSQVHEAQRVLGELGSKVKSDLGNDMFQRPIKEEIGKVMSAFKGGIGKARQASDWAVEIVQGFREGLAYDYNSANDRNTWLYKWADSTQSDIRNVVEKLGDLSKFRAVLNALESSTHDGKNFFEVITEDLYKKLTEAINAIKGELPRRMSNYNNHAKMGGAIHNAIGKVKEDVNGFFYVDGSREQQVRQDKLEGYNRNGVDDEINKIESEGLQHFKKFDQPDNEIKNNTFNELKSAITSNLEGLIEAIKQNADHNEDNTGIKQKLEALQNTYFKQTEHVKNDSIYKIYADLETLQTVNLAQLISMAQTFLVDTIPKQAKECITAIKNHLKAEVIKTVENIKMDALERYIESKSQELGVFKKCVDRRCDTITAIIDEDIKRGIKGLLAIVKQQLSGTALQIADQTKLGDFPSKVQFLLEAFWGYVGGQLTGNDDDVLSAFVGVKTKMTTLFTDLTHYNHEFKNNLHDFSNALSNLKPEHFCGQSSPLLDVFKKGCESMIGELRKAYVAAYSGAFSIDWKGPKTDEISQNGINCAEIFFTILVFIYKHFMTLNEKCGEKGEWLDKKICLLNSTNAYNSLGDFLEECGFHVTEKEDTPDNELRCHGNMKGSNMIQRLTQKQMESTEEIKHIQKCSTDKIEKSKKQFNFFDILHCMFTHLEEYYSLCHIANPSSKQPCSVFEMLNWLAGLHYTAVYPKLLRAGIESVFVKSDKQKNKSIESLQVTVVDQESLSLAAYPNNITYYNVKSAIEHICSKSYIVLTSIVGTGNSATTYAVNFCTNSLGLKYPISGEDCLHTVIDICRKVIPPLRFLQTQCKMSAQHGGWEQCGYGKDVPSAKWPCTENAIDQPTCQPTSPLMSYLNDCLPGHLPHLLTSVGCKSECKTCPSGKPGMPCITPLGFRGFSGSTSTGRDLCDILNELLDDVDLSALLCVVPKPPSTLPEHFGFALTLVHGWYDGAKKIKNSFQRHVYDAITKQSISLYHDPGVLTDALRKAYCSQPPNCGNEHKNAEHSDVFSLSLNNYTRQCSGENHCAHYIYSLSSDSHYYIANKHASVCLSWALYLPWQFHTYLNSLLQELKEIFCRDWECSKCLHGKKCKPGHHGVIHTKTQNSSCQCDSVVRCRGVLPTLYKYGFTFGDPSALNDVRDPKTCSNFCSQLEKVIKSSYFTVLFNECDNFLWTIRLPFSYLLLTLWLLSLLYLIHILIIRLDLLHIKSHLRSPSSHRIAAQSLLAAARVGKLAKISYLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCG7</accession>
    <name>A0A061DCG7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication factor C large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768885.1">
        <property type="nucleotide sequence ID" value="XM_012913431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCG7"/>
    <dbReference type="STRING" id="5866.A0A061DCG7"/>
    <dbReference type="GeneID" id="24565240"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306030"/>
    <dbReference type="OMA" id="KRPIICT"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="267"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="809" mass="90024" checksum="E07746F034B66BD8" modified="2014-09-03" version="1">MDQFLHGDGLVDDILDEIQANTSTDGSREFVQQPAPIELYPLDSRVSNGFSSLRVVDLARNIGAGGASTYAVEDMLYAKSCALDKQKVFKSAALLGRGDEFALKTSGYRLGNPPVYLRFYKEQHSDAAGAHERDENLLGQSIDEMFNNILERPDHSPARQGYGTRVLARKVKRGARASNSNESWLLKYQPRYYSDLLTEESVNIEVRDWHFHVHKPQVINWLRQWKCSRLYSAERSQNKQPYQPTRGVKRPYRGGGTAEAGMENEDHRKILLLGGPAGVGKSTVVNVLAHHCGFDVVEINASEDRSKAKILPVIKGVVTANAIAKDKPNLCLLEEVDGLHAAEGQLIGALKDLNQKNMIKRPIVCICNDLYNKNLRELRQISKVIVVDSCDGEALRDRLLNIAKLEGYRVDDQMVDDLIKLHQNDIRSCITALEFMIKWVPTMSAVNPANRNPELAHNLDAFAKDRSQDLIAFLRELFDPKTTPQSLRDKADALSAAIGEQTLCNLVVENVTKVGARSHFNAAALFDIMAQGDVLHNAWWMQVSLTFVKLMQLKSAFKFILPGSLYSTTYGQKVAKSETVLKAIRGGSLLASTAFSSSFAVQVVPALCTILTSSPDKSVAWPNVARSISEIDVLWEAFAPLKAGVVSRLAKLAVLLQVYGITVLEIQGALALDPPILELSCAQDARLGQEFCKTLQQMLKPGGIVSHRANRPTTLHAYLQEIGHLGYAAFARKFSEQVEVGEEKKAKLLCRKNGAPLPPITFEQLLQREYERYHQLVAENDFDSDMRTYGIYKHYGEKCSAVKYIVNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCG9</accession>
    <name>A0A061DCG9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA2/NAM7 HELICASE FAMILY,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0207130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767741.1">
        <property type="nucleotide sequence ID" value="XM_012912287.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCG9"/>
    <dbReference type="GeneID" id="24564096"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207130"/>
    <dbReference type="OMA" id="TCTHAAM"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002863">
        <property type="entry name" value="Pre-mRNA-splicing factor cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="4">
        <location>
            <begin position="177"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="5">
        <location>
            <begin position="617"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="1349"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1589" mass="179244" checksum="C532FBA1F37802AA" modified="2014-09-03" version="1">MSATVEAPVASTLFDLERLDVYRLLQRALEIGRSDARRFSSPEELLSSRLSPEIREVYAALFKGGFNRHDLAALEHSGYVLFLWPLLSLDSLPLIPSIGAESRDGYDAVRFAAVMTCVWAVVEDHSDGRSDYADLLRQVAKEHPVAFECVFYNAAQLFMLESWRSDLCDTRECDAADRLTILELRALLRFFILCFQSFEVGGIRRCCVQLASPAIWLHIPEVVRERNIYAHNRLAQGLFQRSTKRLEERYDTLDDVKGLPLFSGLDGVRSLYELSAVDAEGHRKLNDRARFLLSRDFLNSVLNHFIYVLEDGIDLDAFSSADSTVQERAMQRLMLCENHMEFLIDLLSQLNTRRVVKPLCDAKLILVRCRQTPLHEHLEGSLFKSMLRILNFYVKFYIDEELGTPLAYDKVMEHYYQRFEAFQRVCFTKFGSDEVLKGVHLLSAFEVHQKGGLTELLSQCKSSVLGRLVLELGLFAVEDNDMESPRLMRPAAVNLTPIKEKGKKAVKQFLIGVINAHLERQVDSVAFLNSLPLYPTEELLWSSSELPNANAYIRMSSLALNKLNLQYLTVFDFLYRNFSLFRLESASQIKYDLEEAIDSCCPRAYLGRGGSKSGQQQLVETRFEGSHPMAIGVTSFTIRNVSSATVLHSDSSFVDAEIVVDTSLIKEFQVRRDWQRLKRYDVVFLVSVSAPLQQVRKRLDEYESPEEVPLNLGINLVRGAEICQVLDEEGHVISDLNPYETRTPIGFRLVLRVRLDYNQYLEDISRDPNIYGHMNLLVRRPARVNTFKAVLASLRHMINRPTALPGWLSDLVLGFGAPLQCQYPQMEPPEWRLNLLNTWKSVGHFMETNSSFVVKAALLGDSADGWEAREVSESELFVRPLQGSALTGADGAAVAANVAGDFNSWCALSQLGLRVDPATLQPLGNGRYMLSTSVGFMVVEVDGSMLASMNEKGAVVHGQRSDLRLPPKVALLVPRFHVPSPRAELAAPRPNIVFTPAQVEAIRSGVSPGLTVIVGPPGTGKTDCVCQIVGILFRNLPEERTVVCTHSNYALNDIFTKLVLNGHVDEHHIVRLGGSEFEIEGLGDFSKWGRVNFILQRRLDMLALVKKLVDALEVPGDYNFSLQLSLSFFNSKVLPLLRHQGALSVVASDPGDTNPTNEADQGAAGDASSELKDVNGEGKAETSPEGRADKRANNVPRLLALLNGFFNSEVEFAPSLRDLSTRWQHLQLCGSAGDAQLHEKRCEFLMYMYSMIKELQPFEVLRNNHDRGRYLVEKYARLVAMTCTHASLGRETMESLRYSNLVMEEAAQVLEAETFALLAHPLKRVILSGDHYQLPPVVNNRSLLQFSNMQQSLFHRLVRLDTPHVILDRQGRCRPEIASLFTHFYPVKIDNIDLALSLPEFGSCNRGFEHTVQFVDCAGSESAPIPHYYQNLEEAEFVVATYMYMRLRGYRSENIVILCMYNGQRALIEDIVKHKCAWNPRIKAPRAIATADKFQGRQSDIVLLSLVRTARPGHLRDPRRMLVALSRARLGLYIFGSWRLFRGCRQLQQFATRLDAYPKQLRLLPDDTAASAVSVSRYSEMEPILQQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCH5</accession>
    <name>A0A061DCH5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0306180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768900.1">
        <property type="nucleotide sequence ID" value="XM_012913446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCH5"/>
    <dbReference type="GeneID" id="24565255"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306180"/>
    <dbReference type="OMA" id="PSSFWIF"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="531" mass="58680" checksum="A7E4F62CD7DAF418" modified="2014-09-03" version="1">MSETQASSPAGADAKQEAKKQVEDYGPFGQVLYHIVSFTEGYEQQVLYLCMRLFESTMGFTKQQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMAAGLLFMGIASILLSSTSRYSSILFLRFIHGAAFGCIYPVQQKIISDKDDDDERNSSSSTFTRLHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYVWISVGIAIVFAMETDKELISPYKSIMGFVEQISGAFKAVFNSWSAFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDLKVGIAIVVTTIGGAAGTAAGGIVIDKITGLHPDYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIEDKYQASASAIIQCISGISISVSFVEIFAYVSEKLHGYAPSTQAIDDMDAALKDNNTEALRKSTMYMIVIGSLLNIACYGALFATYKRDKEEVKVKNVVEWEDRKKRQEARQFSSATLGETEATTIPEDLPIEDYSRSRTDDEEELSQEEINEIIRTGRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCT7</accession>
    <name>A0A061DCT7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769065.1">
        <property type="nucleotide sequence ID" value="XM_012913611.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCT7"/>
    <dbReference type="GeneID" id="24565420"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307830"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1456" mass="161982" checksum="852641CB23F94A6E" modified="2014-09-03" version="1">MATSIRLDTLKDCLQFLEWLYSGKGKSIQPQVATALADRLKYKYNDANTGKIASALSAFLTKVNTFHKKLCSNAQSGSYGGTQPIDVLNALLQCIPKFFASLYFLRYNVDVNFKAVGGGEWAEKYVAYYHNEPLDKYLYATYKEQQYGVIPGGFKQGEVKNWDTYHGYIQGKHLLKHITDILNKYSTTHNFFLDVFSTSVIPDYGTHDSNTANVLALVRSFCDIVKNENNQRGGELIKKLNQDLVTRGASICWDNLKAHCETLKTEFSKIFTDQRFSFTGYGREPKDLSNENFAQTTAAWLRNNLKIIKMKLEKIQPFDTTKVNFNSKLFRNINVLLPTQSKAFADYFTDNFFQYEFTFYSNKYETRSTQYADLFKNWQEVISMLRNTGGGLDRLTTILDGELCPQKGDEEHNDDKKLEDEDASPEPEKVEAPPAKVPETPKEVVPEKKVAAPKKPEVPLEINSAGNQNQGKKAESAQNQGKKAEGNQNQGNDHSVANTSISPVSQAVRTQSSSVQSPDSGSPGATGPSSGPGPGGQADVSDAGQPGVQKAQANGDANGTASNTPGAGSVGDVGNGGSGGPGHQGENPQVPVDNCPSSKGFMKIKLWRDGGTYCVRQADYNEQEKRNKKWDEQQREYDKRMEQIRIEEQEAQQKQEVNQGRKDARAYRKEVVNDQRETLESMERKPQQIHDQYPSELRQMQQEQLLALEGSVITNTKPRAHMDVDKVYRHTLSDVDGRMISDTDRAVVAFYGDEFGRGEIPPVEAVPSTKSHVSDVIGMPTASIAVPAPPVSYHPSRENRLGMIPPPVEENPSTNDQRDSTLKPDDISVGGSVIPMMPFPGVYNIELSLPQKPKVQVIPNPKQRSPLPPIALSEYSGHHYYIPSKYPFIATVDDQTVEKMLNVTGTSNKLQTAQIVGDSNVATLSTPELTGNIISAFKQDPRTSRFPPTSKPYGDDDDASVEYASAVTFNDNIMKTMAGVAGHPVVGTNGQVDISQIPTAISLDAGDIHHLEGQEIEDSFTMKRQEQDLLNFQNEELKQGSQNAQRERELLALKQESDHINEEQKKLMQAAQVDADRIRAFKDSQFDISSAPLRVDEMQFDIQIDVPKRPLQDSSYDIDLDDPYANTADILKDELKPSDDEGFSGLPNTNFDLNFAPERIGLDGYEDPGMPSDSPRKASERVINPFSTDECLNPWSVDTSSTDIINPPPSSVPVTDHLPPPRTVREMLYWFVGLNTQGLIAKIESHIKSILNDISNDASQSPYAIEVTGYPTALTASMVTSKLTEACLYSATVIYKIRHNNDFKAFSTFDFKSEYTKFCYSPDAASLLCQLRDYVYACHYQLEFLKSQCNRDKLSGGWKNDEYGSDITSLNSPLQAFLTDDWDSDFETHLFDPCNLCLKSRVRMGFRDEDLPNLSQSGSVISTILTPSCGGDDPLLTLSSYLNCLTNPRILRTTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY4</accession>
    <name>A0A061DCY4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-BINDING CASSETTE TRANSPORTER, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0308770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769160.1">
        <property type="nucleotide sequence ID" value="XM_012913706.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCY4"/>
    <dbReference type="GeneID" id="24565515"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308770"/>
    <dbReference type="OMA" id="RIVEPSH"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="914"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1089"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="509"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="854"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1247"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1465"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1475"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1547" mass="174033" checksum="71F61EC62F38B94F" modified="2014-09-03" version="1">MGTTYETRDTVEMQVDSSVDSCRTGISQKGCKADKVPTYDDKGILNFLLLRWVVYWVNRLKSTYFELSMLPPLPKPDQISYWQPVFSKHISDGLLMLEEAKAQAVLPIGESKPKKEHHHILMRAILLTFWRRILFLSFLAVIDSVLNVGVAMLLKFLLDIMKRKDQLPFKVVGMLFLIILVEVVHSIVQQHRNFYNRRTEILMEAVMSITLFQHGLCHRKDYCVAAEKHGQLNGCKDAVHSCNTEYSSCSPNPLMCPARRHKNAELPPSMYTFLYFDTCHMASLTNGIATVIRFLCSLVFGMLIIRSQIGVDILYPGIAMLALTIIMVAIEFMSGYVLKHLLTFRDARLARIGEVIGSLDVIQTSGMEDIGYNIVNDSRKDEMCFLKLRVFLMLINRAIMNSVGVILKLIVLLEFISVVKRAADKRDFDLAAPVTLLFVVAKITTSLTKLPTTLKFLIEMLASYGRLSKFIVECSPNYYLDAKDTPAGTSTALQLMNKPTSLLSNKHLVVYKNASFAWFHTIEDSLEEVSIKVPILNDLNFELERGDVKIITGNQGCGKTSFIKAMLGEMSLVSGSMAVAPLSTGMPIFYTSQEVWLPSGSIRSIITFGYAFDEDIYRQVTCAVELESDFASWEDGDMRVISEKGYSLSGGQRVRLSLARALYAYLIFSKANERLVGDRCCFLVCLDEPFNGLDPAVAGTIFNNLFNKETGLLVRDDVAVVMAMSKIYMDLFSNLNMFDNVVHMERWDIDNGSMSPSTRCNEPSNVDVPSSQHKECFTTEGGLKRASTLTRMPRNIYQVCESGEFSTMSLGYMSCVKQNSITKAADEAREQNERCSTSSGYLRYLEAVGYKTSFFIIALIVVSIVLQKANAIYIARWSDTVRDLGGCDHDGNADVDVIFMAHEYESFLVKLFSFFYLYFLFVAFLLMVVGSLRCSSRLFSFALNSIIHKNSSVITLKRSIGGIITIFSSDFIHIDEKFCKQVSSTILGLIRIILQAITMCYTIPLASPVPCILVLCIYFYVIRRYFIPAKKLECLMLDATSNINELYASTISGSPLYRSYRKEGQCIEAITTQSEYFYRSKYLKLALNVWAAVAAKMMTCCGAGIMFFIPIICHYAFGIDLRIAQIGLGISLTLGFNDSLSLVIYNVAVVERQMCSLARYTRYFCQGKCTFRDMFESMRETVLCQYGGAGHTENDRMRLADLEKRRKTEYRRLMFRKYVSLWDRQLHKCTIELLDASQYLPSNHMTLELDNVMVPEPAQEFNASTNYILKGVTASTRAGDVVGIVGRTGAGKSTLLSVLQNIASKREGSVLLDGRELNSIPRKVLRHIIGVLPQMPFVFKGWTLRRFLDPRMLHSDEEILHALECCGLLDMVKSLPGTDPLDAVLAHEDIRVQRGYYVIIPLIRLKRRLTSTRSDDGEGGVSGERPDGNVACFSMSQLRSLSFARLVLYRMTYRILLIDEPPSDNCAGHEEADQAGGSPSGAEASSDASVPIYDLVRMFFSHCTTFIVAHDKNVLRSCTSVWLMQSGTLVERCSTQEFMARGLEQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD58</accession>
    <name>A0A061DD58_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769310.1">
        <property type="nucleotide sequence ID" value="XM_012913856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD58"/>
    <dbReference type="GeneID" id="24565665"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310270"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="177" mass="18723" checksum="B126DE318F128FCB" modified="2014-09-03" version="1">MVSVLADVRVHEWLRGLGAAVAEGTGRGSVEWEGKGKMGGRTYRYGTSCGEGCASQRKTCSDIYICGCNCCLEKRTRAEVAASVSLPSTGAESSAPSGVVPLPGVTNALHGEQPSTGDPNAKASTPFRPDPQAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKMPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ4</accession>
    <name>A0A061DDJ4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0313810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769665.1">
        <property type="nucleotide sequence ID" value="XM_012914211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566020"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313810"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1829"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1891" mass="211196" checksum="E766070E67B5F5EB" modified="2014-09-03" version="1">MTSINHPNNLCYVTLHFPSSTSCHCPDHVPLRELGKKFDENKKCEITSNNNPTIILNNLCSGLETFLGFNSTSKGYDGSGIVYSDLDRLCDGVMGFLYQVLKDVSEKQPYSVGKEELKKLVTDLKTKLSTGREGFKVIAQVARKVREYNERVKESNNHVKTIINNMDRDMKTLQNEVGKILQHNPDSDDLNEVKQAETLVTKLADEYAKKGMNFDSNFVIREMNAWRTGAKVEPIQQFKDINSDLRLKITHARNNITHEAERLTTLSKKQKENLAAMTSMISNKLKTLKSCVNERILKDVNELVKELNDKVGIILEQLVMIRQKLQGYVEKLRRWIRDADEIVTDCMKTAENIEKKHVAWAAEDEIKKSLKEINKSFGEAKDFVKQELNNALGKVRDMDEAIKKDLFAVKGKIKEAVKALGKTLEENVKDGLWAIEQKITKPLDEVVRNSGQFFEDFKKTRNALQAAIGIVMEDILNLGGLKVNESIKNAYGDTTIKAPLLQVIGQGMAFSKLKTYFNQLDTDVMQKIKEAMRQISEGMESIAGNAFRVDLESCINKARSQLVALHSIAENPEKVFQSATLQKNLRRYLGDKMTIAPLNGKFSGLSTAIKAVTTDLAGASSIDASKLKNDLKSLLSELGNIAQIVSSHSADIVKTVIEAIVRQLTTEIGNVSDAIKDKVDKIRDAITYNRDNNEVDYGAQEKAKGLLKLQNVYGTDINERLKTLQGTVTNEAFKHTYSQPRSKENYEFGGTFMEEFKTTYEKNLKDGDFKADGGESVLDQEIGPNNLPNGGSSGDKISSVAKSNFTHYEQHVKQESLAHSNPQKLEGALPTAIKDIRDYGLQLFEQKLGAKEDRNTTKFDGFLDDITKSISGLMQALERTGKSLNVALGKLKNEKIGMTTSGAAARSDTLQELEKNLLQLFGVDLDQVIKDATAFKQQANQLRDKTIRDLNGHVEDEVKKAETALITQANKNYVTSVKDMLQAFADKVQKELKPLPGEIDTDRKHGFKGFMRTLEGAIRDDGDTSDENIDKLKGLVGELSRNVNHKASFKNLSQKFKEFCSPLHVYLKAEIKRVHEAYKEKINPKPSGAEQLYTSKLDAANTALNNLLNHISNHRYNHEVPTLLDSLSTKVDGLHPKTFNEPSTPLLDGVGKGVHGFVSELGKAYISAYDSETFGGEMFEKDKLTPYGAKFAKICLTVVCTLKATFTDLTHNCKSLRGQQINKSTDVGRSFVGHGYAVSDAALQNGELQNKPTVAGENVAKRLMLRISGADDNQHLRWCESNEQRKDNHFHVFDVIDCIFSHFEQYNELCHLLTASAKQHPCSVYDILIWLSGFPYTAVYSAMRDITITDLFDNPHKKAAGDDELDLTSTDMAAQSITSHPRNISYNYVRKAVEHICATSYDVLTAVVGTGDSRTVYASDFCNNSFNFHYPSDPSDCLDMLLDLLRRLLPVFRFLELQCNIKPEHHGWSHCRYGRDIPTTKSQCNEHSGDEANSQARCQVNCQPTSPLMLYLSDSLPGHLPHQLQSVGCRAKCSTCSKSAPGQPCLLPLGFKGFSGSTKTGRQLCEAIKIFIGTGLISSLMCLLPKPPSTLPEHFQFVFTLVGAFNASRDVNSNAVHAAFVKAIKKQSIDLYAEPSELTGALSDAYKNGRSHEVGEHPKASDSDLSTLSMPTTCNYPNKDVHCAPYLSTLYSDAYHYAAEKHAGLYLSWAVYLPWSFWQCLESLFRAFTNISCQDWGCRRCTHGTACKRGKHGAAYNCQCKGLVECRGVISTLYSFGFTFGNPATLSAAEGKRYCHNFYKQLNNVLNSNYFKTLFEKCDEFIFTIRQPFIWLNVALWSLSLLYLICVMVGRLDVLHIRSHLRIPSSHRITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDL5</accession>
    <name>A0A061DDL5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302050</name>
        <name evidence="3" type="ORF">BBBOND_0302590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768487.1">
        <property type="nucleotide sequence ID" value="XM_012913033.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768541.1">
        <property type="nucleotide sequence ID" value="XM_012913087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDL5"/>
    <dbReference type="GeneID" id="24564842"/>
    <dbReference type="GeneID" id="24564896"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302050"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302590"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007370445" evidence="1">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="73" mass="8043" checksum="623A5C8F4C6F02C2" modified="2014-09-03" version="1">MSSNGYRVRRVIAAFMLACISSSNGQVVGDPETGDPRLVEHLRQEGFHTTPMTQNSEHGDSLRVTLLGLPKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDL7</accession>
    <name>A0A061DDL7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">-putative, 30S ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769715.1">
        <property type="nucleotide sequence ID" value="XM_012914261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDL7"/>
    <dbReference type="GeneID" id="24566070"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400210"/>
    <dbReference type="OMA" id="HEACFIS"/>
    <dbReference type="OrthoDB" id="375701at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="200" mass="23813" checksum="E8729E8EA22F6287" modified="2014-09-03" version="1">MQMYALTSVKISYVVGGRLTRELYKTLRRRIIRGSEIDNKQKYNIENHKKTTLDGKLLGPKTCYNIYLALDNRPADEIKRRFQLIAQNLIKVGAEHTNVYYYGLKKLAQPLNKKHEACFISFELDIYPSLIQHIRKKLSQEEHVLRVLVLRDTQKDKSRRVHRDRRLHVRHPYFDTEIFRPHRSRLLNKPGEEFSIAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDQ5</accession>
    <name>A0A061DDQ5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0303740</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768656.1">
        <property type="nucleotide sequence ID" value="XM_012913202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDQ5"/>
    <dbReference type="STRING" id="5866.A0A061DDQ5"/>
    <dbReference type="GeneID" id="24565011"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303740"/>
    <dbReference type="OMA" id="YCGVKGY"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002432">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="183"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="413"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR96470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="547" mass="59533" checksum="5E8A0E216FF492E6" modified="2014-09-03" version="1">MRNMKPLGRPLIRTLAAAVARRLPHAANARAFSTAKISPAEMSKILQSRIAGWDKHKDVVDVGHVITVGDGIARVYGLKDVKMGELVVFSSGVSGMALNLESDNVGVVIFGDDRSILEGDNVSRTNRIIDVPVGPELLGRVLDALGNPIDGKGPVEAKLRNRIEVPAPGIIDRRSVHEPMTTGIKCVDSLVPIGRGQRELIIGDRQTGKTALAVDTILNQKQLNDAKDEKDRVYCVYVAIGQKRSTVARIMKTLEDKDALKYTTIVAATASDSAPLQFLAPFAGCAMGEWFRNSGRHAVIIYDDLSKQATAYRQMSLLLRRPPGREAYPGDIFYLHSRLLERAAKLSDKNGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELFYKGIRPAINVGLSVSRVGSAAQIKAMKQVSGTMKLDLAQFREVAAFAQFGSDLDASTQKLLTRGTLLTELLKQPQYVPMRIPLQVCVIYGGVKGLLDSIDPKDVSKFEALFIDHLLSSHQDLLKTIETEGQLSPETEAKLRQTVENFVATADVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDT5</accession>
    <name>A0A061DDT5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768741.1">
        <property type="nucleotide sequence ID" value="XM_012913287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDT5"/>
    <dbReference type="GeneID" id="24565096"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304580"/>
    <dbReference type="OMA" id="ESIFCKE"/>
    <dbReference type="OrthoDB" id="340921at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596249" evidence="1">
        <location>
            <begin position="18"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="28263" checksum="2D8C17C279917EC2" modified="2014-09-03" version="1">MAPILAVLALAVQLCLAKHKDKPKKAHIPNIAPCGEGLKGLLNYQFDREDEEAVITTAAYLSKNTVKLYTGNVNYRTIDLNDAISPLETLGEKCFAIRSRDALPNVLCASGLLERNRWINSIEASMLCAETGIKSTLPLIPGEERLEELDKEKPAGINLFIHDSPVGRPEIYINGKTTKELEDERNKQSIDASHVINDMQELGDLDQLFPTFETNDGEPMTVAPIDEEALAEARAEAGMVDDTTPDLGYYKHEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDW1</accession>
    <name>A0A061DDW1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0305280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768811.1">
        <property type="nucleotide sequence ID" value="XM_012913357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDW1"/>
    <dbReference type="STRING" id="5866.A0A061DDW1"/>
    <dbReference type="GeneID" id="24565166"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305280"/>
    <dbReference type="OrthoDB" id="366099at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="239"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="370" mass="41639" checksum="4713FA46097BDB4E" modified="2014-09-03" version="1">MMHAAARSFGNIEQLLEAFFGFLCTQTDFYHTQLSDGDIAKFGLDRSVNNRGFKPDHVRSMIARIFDKNLRLYRERYQPYLLGIPVERTPTRTRTTNHRSAPIDEEFAKTPYVPGQFLPRETAKYSVEKHATGSSTVSSELPVKTGQGTAFYDSSLSIGMSKNPSTVNGGSYQGGENTVVRNDSSRYANQAEAPVPNKGMIENQKGAANGPMLPQVSGVDPYALERLRTDFTLSPFNGGKTNVYCWNQTFTDVTIEVVTSEFLAAKDVDLRVTRDHIQLNLWGKHIFSGKLPQPVNAAEATWSIEDKRMLVISLDKTEERWWDSLVEGHPKIDVTQIESVKRFDEFSAPAQNEMLNLMKQHRDRQSQGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDX5</accession>
    <name>A0A061DDX5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">-tRNA wybutosine-synthesizing protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0402570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769955.1">
        <property type="nucleotide sequence ID" value="XM_012914501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDX5"/>
    <dbReference type="STRING" id="5866.A0A061DDX5"/>
    <dbReference type="GeneID" id="24566310"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402570"/>
    <dbReference type="OMA" id="FRDFWAR"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="395"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="743" mass="82263" checksum="A1988698A09E0541" modified="2014-09-03" version="1">MDAITAASVTLAYEGDDCGNDACAGLSSIVKHEFASIGVQCQSVRLETLLDRQRYEVSKSNAYTNSEANEDIACTLVDICRGKQGCRDSPALTTLVLVVDSKVRAPALDNILVTLQEWLADFRISKTLLKGLCCTVVACRSDAGTANTANDGHPSREVIDAVIALENSMEALGAHIILRDTLCFGPTDIGQIVTFTNLVSEAWDAINFAATRNESNVNYVGDISGQHALSVPSEGRPELHRHRGSDSSPGGGHQKTSSYVTLNAAAHTCCRSGHTATPNGHPGNDTSSNTKCCEAGGDQGTCHCNDALNGSSSQADDYTSDEEENTNTVQVAGCMAESDIENVALDGGKMVTETQRQSLTKQGYKLIGEHSAIKLCRWTKARVRGHGGCYKHTFYGIKSNQCMEMTPSLACANKCVFCWRHHTNPALTRWKGTIDDPDFLAEESVKAHLRLIKELRGIFDTKSDRLKEAMQVRHCALSLVGEPIMYPLINELLLELHQRNISSFLVTNAQFPKAMEGLRQVTQLYLSIDAADETSLKKIDRPLFRDFWARFNRCIKLLKQRKERTVFRLTLVKHFNITEQRDEIGNYGRLIELGEPDFIEIKAVTFCGTVHDNAITMENVPWHDEVIQYAAALVDASPFTRENYAIACEHRHSCCVLVAKKSFCVDGKWHTWIDYDKFHELYPIWKQATSGREFHGVEYSIETPEWALFGSKEQGFDPIDTRVYTKGRKKLFGPPTSPPSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE95</accession>
    <name>A0A061DE95_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vta1/callose synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0405680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770270.1">
        <property type="nucleotide sequence ID" value="XM_012914816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE95"/>
    <dbReference type="GeneID" id="24566625"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405680"/>
    <dbReference type="OMA" id="YAVNALM"/>
    <dbReference type="OrthoDB" id="10356593at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR98084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="211" mass="23786" checksum="B8271E628CAC0A35" modified="2014-09-03" version="1">MKLHPSQYSYIKRANELEEISPASSFYCLNYVIDKVSQVYQDNKSDLEVKNTLIQLLDRAETLKEARGPFELSQFVEFASCLLDAAEADNDPQSAFNRFFVAGKLFDVVVHFSGDSKHKELRRYAQFRALQEKRQISGDESSTSQQTIEEASESAGVSSAQHQHTNAIRETRSETEELKAPEHTPAAEAYDLQMAENAMKSARLAVSGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE4</accession>
    <name>A0A061DEE4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PITH domain-containing protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769321.1">
        <property type="nucleotide sequence ID" value="XM_012913867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEE4"/>
    <dbReference type="GeneID" id="24565676"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310380"/>
    <dbReference type="OMA" id="RLVFKPW"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="197" mass="22116" checksum="B56EC6B83B981B4E" modified="2014-09-03" version="1">MHFSGCGCKAEHELGTSAACLRSQIDLDGVRVFNSDASPESGNLVFKPYNSRLSEETLRSDPASDNELLFTLRFYNPSDVAQLLVVNDTTQVLHVRLYANRQHFDFSDVEDVTPTQELDLPPDAHGSFLHKLSFTKFKDVSDLALHFSGEEPIELRYIGLRGKSRVQQANVVDAKYELVPTASFQESLAEVKNFKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEH9</accession>
    <name>A0A061DEH9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769496.1">
        <property type="nucleotide sequence ID" value="XM_012914042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEH9"/>
    <dbReference type="GeneID" id="24565851"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312130"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="6816" checksum="6F2C4363A6F7A06F" modified="2014-09-03" version="1">MDESSKVTPLTNLLSKPRSALGDKGTKRKGDTKKYLMVRKASATSLDPQPITCPLPSADNIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET3</accession>
    <name>A0A061DET3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770016.1">
        <property type="nucleotide sequence ID" value="XM_012914562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DET3"/>
    <dbReference type="GeneID" id="24566371"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403180"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="8246" checksum="536B4F9ADAA41C29" modified="2014-09-03" version="1">MGRSHSMLHLKLMQDYLVNDLIGVAFNKWTSFDVVHSSIRDVKRINHYGCKWPMYLQGSDVFDTSDEQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYZ1</accession>
    <name>A0A061CYZ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal L18p/L5e family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0101600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766017.1">
        <property type="nucleotide sequence ID" value="XM_012910563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYZ1"/>
    <dbReference type="STRING" id="5866.A0A061CYZ1"/>
    <dbReference type="GeneID" id="24562372"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101600"/>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="9">
        <location>
            <begin position="239"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="35638" checksum="2D0C9B3E83A058DF" modified="2014-09-03" version="1">MAFIRVLKSKAYFKRYQVKYRRRREGKTDYYCRRRMVLQDKNKYASPKYRFVVRFTNKRIICQIISATIVGDKVHASADSSELKHYGVKVGLTNYAAAYCTGLLLARRLLAQLKLDTQFIGKEEADGESFHIEEEDHETRPFKALLDVGIKIVTTGNKAFGALKGACDGGLHIPHSEKRFPGYTVGDDKQSNYDAEAHRDRIMGVHVANYMREMKEEDPEKYQKHFAAFLREGINEDNLEDMYVRAHAAIRQNPIIQKEKKPAPSRTIKGHTVITAEGKTYVRNKKITKEQRRERVRQKMLMCVQGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ14</accession>
    <name>A0A061CZ14_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765879.1">
        <property type="nucleotide sequence ID" value="XM_012910425.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061CZ14"/>
    <dbReference type="GeneID" id="24562234"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100220"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1578"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1651" mass="181857" checksum="48E742A5AF4F4D2A" modified="2014-09-03" version="1">MTGHGIELRTLRDCLQFFEWLKDAKPMHPQLADELVKRYGESYNHISFTRQLPPDLFGFLDRVSTFYKKLATAPVGGSYVSPTAPDVIDALLQCIPKFLAALYYIWYNVDFKLEAVGGGKWKDLYVGWEATRSWWGRYPESGGELQRYLRSSVSINFHVLPGGFGDNEVICGYDYPRYGYQFGKNMIKDLNNILKTKYHQLFRDVFSTSVVSKFGTQYSNTANVLALVKMFCHMVGTDGGAIKRALEKDLSGKCIDWQQLLDHCKRLESQLGNLFKDDAFSHTGKAPGIDTLHSENFAKKTAKWFRQHLPAVQSNVKKISAKYPADDSTWLNTLHPFVIKNVLPYGFVFGDNSYGTMGNAWKTLPPKWNGTIGMLKQENGGLKKLKMLLEGGACKAQPSPQPPPPPITSPQPSSSSVASTSVAQGSGRQQNQVHHIVLPGNGASGGGGHSQRPNNQSQGAQQRSSHVSPVTDTAGSSNQNNGQSEGQPEVLRSSNTVAPTPTGKDGPGGPTGASGDRSPEGPKVEKGDQGPQGHPSTGSTRSSPSKDAVQPRQPPSQSLPSPPPPQTPSSPTAPNGPNGSASDTGAVPRSNDASSSEPAATLQVTITQRPSASGSDSESSGVPDSGGGMGPGGQANPSRSIQQNGQVLQRNDNAGTTTPSVQGSGSVAGGAGGSDMQRGAAKQDAFKCSNATLPFSFGGTTLCQPKSQKATGNYDDIWEKAQKKTFDQDLLKRSQKTNLLRKHKSHISASLPSHPDHSAPGISPQTTRGRAGRVKPYYNPQERNTRQGSINVRDPGIPKVTLEGRALSENARHIKEKEVKEAERKRLFQQKIQDGINAEIENKIYMRKLEDEEENKIEQHTKNGGNDFEKQTFQRELIDGLTTEVLNPYPPGPKIGVPVGYALKHPKTAIKPLPSQSIPDIMSQPIPDPNRGHRLPPFPPNYNPTEHDGPNRIKTPVTVQLDQSSDENLNISTTYLATNPQRDVRAATSQETKLTLPPALISGWTISDPNLKNYASFIPTADLDPPPPPPPMSIKVKDFNSHDNVLKSELTRTHTAHIMHPIDPASPYDTYPGLPPVWPPPDLKSDSGADYNDPRNWGRFKNYGFDLFPNPDMCNNPWNYVHNSTTSPTLPPPPDSDHLPPPTNVKAMLFWLVGFNTYGLIAKMERHMENILNEINSDTFYPKYALAITGDPSSLSASHIADTLTEACLYSAHVLNGIMRMKSEDALAPIDFKSVYSKFRYSPDPACLLCQLRDYVYACHHQLQFLKAQCKRDKLSGGWKNYEYGSDITAPNSPLQAFLTDGWDSTFETHPFDPCNLCHKSRIRMGFKKNDLPKTSQLGSVISTILSPSCGGDDPLLTLSSYLNCLTRRTPRTTGELVSFFHNFGNEMHGYASDALSLLGNSLRNPHLDCPDWDHLVRQDLQVVKGIRGHASLIYKPNSKHYHPRTLSTLVGCGSDPDSCPQHCPPITYRAYALYSQSFAHTYLSWTVYLPDRLHESLQKLHYDFQKHKCSSDKFFHSCSTALPLLYLHGFTPPEVGSQPKLTCSNVIEKIKDIVAGKPIASLMTAMDEFLYNIREPFIFTLVALWSVALFLCANTMLYRLDVLRIRSHFTRSRGSHVIDVKALLTDGTKMPSLYDIDYFDEDPIGQLVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ74</accession>
    <name>A0A061CZ74_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766112.1">
        <property type="nucleotide sequence ID" value="XM_012910658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ74"/>
    <dbReference type="STRING" id="5866.A0A061CZ74"/>
    <dbReference type="GeneID" id="24562467"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102545"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102545"/>
    <dbReference type="OMA" id="CINQFAN"/>
    <dbReference type="OrthoDB" id="365641at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="325" mass="37189" checksum="BA666383EF588D18" modified="2014-09-03" version="1">MEVNDTSSTEVIPLCHVVTVVSDVFLRFSNIERIERAVLQNAAELLARQVNMFTVYDSHSVLRRHFMRKYGGYTRCSVLTQPRRTVYDLDVSDCSSSVDGFEYNSETDSDSDSIYFLERSGSDFFLSTFHRVQHASRRGLRLCFLDRNHAHQQILSLSPSGYAPLDDWIDTPGVFLRSKQVRYRVPPEHHVSQLELQRQLNSIDGIQLPNADLVVTVYPGIRDSLLFLIAFFWLSLLQLLKCIFPRRFKPTMPPKLDLKLLLRCIAARISGAFCFGGSVIYSFGTDGIPPFFLADSELHQCFGLTVAAFSRCVDRYYTCQRRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZY3</accession>
    <name>A0A061CZY3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0104700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766347.1">
        <property type="nucleotide sequence ID" value="XM_012910893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZY3"/>
    <dbReference type="STRING" id="5866.A0A061CZY3"/>
    <dbReference type="GeneID" id="24562702"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104700"/>
    <dbReference type="OMA" id="NPWFTYA"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="249" mass="27485" checksum="5CE20C2393D16613" modified="2014-09-03" version="1">MAASVDSRAEAANYYDPEKNATGDHYCFSETTPMYIRHEFVKKVFGIVTIQLATFAFMLATFNVEAMKQFFLLRPYIGIVAIIIFMIASIVVVCKRSLAHNKAVAASLLVLMTGCMMLYVACFAVHFAAFEVTVAAGMTAGLTLGVTLFAMQTKYDFTGYIMHIFCFSLGLFFAGILIAIFPSRALRIAYSTVGALLACVYLVVDIQLAVGGRKHEWTIDDYVIAAISIYLDIINLFVHLLRLLGDANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D030</accession>
    <name>A0A061D030_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766214.1">
        <property type="nucleotide sequence ID" value="XM_012910760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D030"/>
    <dbReference type="GeneID" id="24562569"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103420"/>
    <dbReference type="OrthoDB" id="10628435at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="26083" checksum="A41237430C67EA05" modified="2014-09-03" version="1">MVHSNACSLALYSEVVPASGGITLSVASLVARGTGQRSVTLASRFWLMLQNTLMVTLACIDVNCVAAPTTESLFNSIAAFTLNGSTALPDMRYVMSVNSPSMGVNESTRDFSNSEVSTLWCRLQKSSTGTFGTFPRRLLITIPSLSASLTGGDPRRKLLTWMCPSTVTLLYVSSAPRTADSFSTTSTNISLPRVEPPASGRCETTLGSVIGYAKALERIPTCRNFTNAGAKLTTGRECVAGMTATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D062</accession>
    <name>A0A061D062_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0103720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766244.1">
        <property type="nucleotide sequence ID" value="XM_012910790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D062"/>
    <dbReference type="STRING" id="5866.A0A061D062"/>
    <dbReference type="GeneID" id="24562599"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103720"/>
    <dbReference type="OMA" id="GMMDCLL"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="73"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="23000" checksum="6758651478DAAE87" modified="2014-09-03" version="1">MVDLAIRKNNVAQGKAKKTRKFAEVKRRMSPKDSRIATVKAIKKTAKPEPLVEAPKVHSGMFFNYNENLVPPYQVIVDTNFVNASIQNKLDLHKGMLDCLIAKCIVCVTDCVVAELEKLGHRYRLALQLVKDPRVERLTCAHTGTYADDCIVERITTHKCYIVATNDRDLKRRIRRIPGVPIMYVANHKYAIERIPMSITAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0H5</accession>
    <name>A0A061D0H5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766359.1">
        <property type="nucleotide sequence ID" value="XM_012910905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0H5"/>
    <dbReference type="GeneID" id="24562714"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104820"/>
    <dbReference type="OMA" id="NWARIAW"/>
    <dbReference type="OrthoDB" id="372748at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="484" mass="54339" checksum="FBCE2DBAF5EA3CBC" modified="2014-09-03" version="1">MDHIGPIAQEGSPCDISMSETLVGYCSPEEQGYYVPGGMAQNPVGCYYDEGFVPAGADYMSTTYYQNGPEDLSKTVAPPMYVYSEPPIAPMAGYSSPYMYGPMDLTFFPSGDPVFYGMPCSTMAHMVGAAKAEIDDDARTFAECSTAATTPHLRSSVNPEMVDDGFDLAYSPEYESLPMPAVDSRFSTGVAPDGNYYKSVVNFEDAFSPCRYTDAMANDAVVVEIANEIAANVQYLPDKESSGKYSLDKNHPIHCVWRDLNRGHCSWRCRWWENGKRLSKNFNVKRFGEWEAMWMAIAMKIRNSTPVERFQLLKEQREAVRNYCELASQHAGSTVTEDNYMDAAVAAVPPMGLSPRKKRQPANSAKCAQKANWARIAWTYVMVSDRRPSEVSVVCRLCAKTTKCSRSRNLQQAHIMHLIRMHKNPWKKYLDVEGLTKMCSSALDALYKQQGFTEDSEWKLRPGIVPPEPDFEDMSMHYNGFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0M6</accession>
    <name>A0A061D0M6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine cyclotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765883.1">
        <property type="nucleotide sequence ID" value="XM_012910429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0M6"/>
    <dbReference type="STRING" id="5866.A0A061D0M6"/>
    <dbReference type="GeneID" id="24562238"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100260"/>
    <dbReference type="OMA" id="NDKLFQV"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270:SF1">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="337" mass="37471" checksum="1A66AA68CBB91C90" modified="2014-09-03" version="1">MRCDRRSTTRFAIALASLSVLTAVFIAWFYQPLSLFSPDTEFVARVYLPEVQGVRIPHVCEFGSKAVLPFTQGLLFTSEHTLVETSGLSSHSFLREFSASTGATLRRVDLPNGYFAEGSALVVEPSTLRLYVMVLTYTDNAILLYDYASFALEHVYKMRYVGFGLTSNYDIRCKDRSEFVRRQKVWMTTGGSDLISVSLPDSFREGTINIAGSVPITLNGRRLLYVNEMEYNVPSDTVYGNIWGSDYIVEISPYDGKCLALWDLRTLSSQQPTGVDVLNGIACHPSKPYCMVTGKFWPHLYSVTFPKGSANAVDVAAAFYENFCAAEGATSSPQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Q4</accession>
    <name>A0A061D0Q4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNF2 domain-containing protein / helicase domain-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766414.1">
        <property type="nucleotide sequence ID" value="XM_012910960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Q4"/>
    <dbReference type="STRING" id="5866.A0A061D0Q4"/>
    <dbReference type="GeneID" id="24562769"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105370"/>
    <dbReference type="OMA" id="NEFHQWW"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="161"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="486"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="862" mass="97275" checksum="B9F9DB8BFC9A5C80" modified="2014-09-03" version="1">MVLHPQGIKEVDSAILEQKVSSNVDVVFRLHALSKRLKQKIKRLDASHHLVKKYKSFINNIRAIIDRIIVQSLGDDESLSEDASELKYEFIGDSQLRINDETLEISEDESNDAHDDDSESEFKYTNVNNQAACQISDTIFAPITIFDRLYIHQKKGLKWLAGLHHRGHGGILADEMGLGKTITILSFFNALIFSTESKTLNLEGGLHVLVVCPTTLISQWKDEMGKWAPLLKPIVFHGALGSFGKRAIFGKSQRVKYKALITSYETLRVHIETINACHWSYVVLDEGQKIRNPDAAITLAVKTLGTPHRILLSGSPIQNNLVEFWSLLDFVAPGHLGTLPLFTEQFVEPIMRSTDVCNNSAAYNCALRLRELVHPFIQRNLKSEFTDCLRLPKKTEHIIMCNLTRVQYQVYIALLKNVINVESVGNSNLALAVKTSISRMGSKMKSSKFLLLLTLLRKVCNHPDLVLKEHPKDFGNVERSSKLMIALDIISNWEVNGHKILVFSQTIQMLNIIYANLATRYGACRIARIDGDISIKRRSGILDAFEKGEDVFVLLLTTRVGGVGLNLTCADRILIFDPDWNPMTDSQARERSYRIGQNRDVVIYRLISAHTVEEKIYHRQIYKFYLSERILTDPRVMGFRFLPASDLLSLPPKPAGPGDTGEYMHDVEKQLKSIDFEMEIRQLNNTNGIYQRSSDVAKCVSEENPILQSIFAHHEIEGVIKHDDIENRIYANVDQDSSVIADKAIQLLKRSLKERSAYDISVPTWTGENGQAAAPVCCNGRKVPKGGTGNSVSMLQNLRRKTHGPDVAVIRKDMCPMINIILDYFRRAPKLEIPTGEVCNPTFRTTHSRLPVKNSSDYSYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0S5</accession>
    <name>A0A061D0S5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766429.1">
        <property type="nucleotide sequence ID" value="XM_012910975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0S5"/>
    <dbReference type="STRING" id="5866.A0A061D0S5"/>
    <dbReference type="GeneID" id="24562784"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105520"/>
    <dbReference type="OMA" id="FMIATHD"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051309">
        <property type="entry name" value="ABCF_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42855">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42855:SF1">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="121"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="574"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="879" mass="99584" checksum="CB50ED73E36E756A" modified="2014-09-03" version="1">MLFSTLTYLLFALVYYIVSCASLFNVKTACAYLSKIRHYKATASLNRRNVPAYSSSWLPTISCHLGSVFPSRYEHGVSATHESQRQSLELTKSERKLSYRPIFEKSVSTHFGCSKERAPLLDVSDLTLCIGDCVLFDNVRFRISQGECVGIVGNNGTGKSSLLDALYEKITGCNTTSEAVSSSVGVKITSKEQIHFASDHLQVYQLLYFLRIRKHNLDDLSHLRIDELLKSDDYMEFLDGQNIFTSNAYFNNFVAYVQQNYVTNLDDSMLVKDVIANSNTIHKTLLAIFRDIEKNLSSLSDIAGRMDIGSAAALQGSRQGNGELNIEWARRILTVYNNDNMAFQKKSGDVNVVASHLIDMFGMREVLSLRVGELSGGFKMRLALLTRLIHDPQLLLLDEPTNNLDIASVTFLSKVLRHLIETRGLSVIIVSHNASFLRSLCTSILQVPGDGTLKVHECDFDRFLHRGSKNLQSRMSRLNKLQSDCKKLKQQYNAKLECNKGSKNQKKVWLSQKRRLIDDTEELLRKVTGAEKSTYSDAYERSLLLHDSHFDAADLLRLPLVKRGTFVYPDKPAFSLQDATLRSGSEALLCNISLQVHNCDRVLILGNNGSGKSTLLTVLNAAANAATMGIPNVNELLNRRSYVHVADGRCEAKENTSVNYLSQNCSDILTAASTVGTLAMNYGDMDMSNRQQLTEYMSHFYLKDLMDIRVRDLSFGERCRLALALQFLRDSNFLLLDEPSNHLDLYMKRNLVLLLNNVYTRGGIILATHDLQLLERLERITTIFYIHQFDKTYTFKGDFKDTYLRFRREVPDASHTEMGNFLESCTYDYKHEVTPRMFDFDRSAGNDAVPCHPCKRLKRAVVMPQKRSKTKLKNAKRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0W8</accession>
    <name>A0A061D0W8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 90, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0105820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766459.1">
        <property type="nucleotide sequence ID" value="XM_012911005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0W8"/>
    <dbReference type="STRING" id="5866.A0A061D0W8"/>
    <dbReference type="GeneID" id="24562814"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105820"/>
    <dbReference type="OMA" id="QFGKHIR"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599923" evidence="8">
        <location>
            <begin position="18"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="764"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="209"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="798" mass="90497" checksum="04A3D93449D2737B" modified="2014-09-03" version="1">MRRSFAVMLQCIATIFAVIHFQNVEVFANEEKGVESSIDSADFGSDNIQPRIHVESTEEDTSDGAADSEVVITEPEDTVSLSDDEMSSAAKHGESHTYQADFARVMDIIVNSLYSKKEVFLRELISNSADALEKYKILELRENRADSGDELAIRIRASAAKRTLTILDTGVGMTKHELINNLGTIAKSGTANFVDAISKGENDANLIGQFGVGFYSVFLVADSVVVQSKHWNDKQYVWKSSADTKYELYEDPKGNTLGEHGTQITLFLKEDATEYLEAAKIEELIKKHSQFVRFPIYVLTVDKESKEAKWKHVNDVKPIWARDKSEITDEEYTEFYQAISGARSKPLAHIHFVAEGDVEFRSLLFIPERPKSSYFDTDDVGHQVKIYARRVLVSDRLPDFLPRYLYSICGVVDSDNFPLNVSREHLQHSKMIKIIGKKIVRSVLSTLQNLMKESFDSKKKLQEEIDAETDEEKKTELTKKLTAKTTFDKFYQNFRGSLKVACYDDASNRKKIAKLLMYQTSKHKSDEITLDQYIAEMPETQKAIYYASGDSYNAIHSSPHLQGFHKRGIDVLYLTDTMDESCINQLYEYEGKSFKSVQKGDVDFERTQEEVERDELTLKKYAPLIKVLKENISEIYDVQLSRRLTDDPCIVVVTEWGMSPNMEKIVKSYVVNKKDDDVDPFGSGMRSRILEINGDHPIMIELLKRCKNDTVDSSVIDSMKLLYNAAKLAGGFSIENPTTLTRTAYSYLSDQLNVDASATIDDIAYTPEAEDETTESPEDMELEEIDLDDEGKPVNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D150</accession>
    <name>A0A061D150_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GLUTAREDOXIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0108440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766732.1">
        <property type="nucleotide sequence ID" value="XM_012911278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D150"/>
    <dbReference type="STRING" id="5866.A0A061D150"/>
    <dbReference type="GeneID" id="24563087"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108440"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595342" evidence="7">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="120"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="206" mass="22631" checksum="6BC56852DB9E5355" modified="2014-09-03" version="1">MLRYATLLRLQLLAFAVPTQHIVSMHRASSAAAPFQVRRSSRNSTVHAATAHCSGSSQAEEHGSHTTCAPTGCIPQDQQQQEAAESNARESLKNLELTAAAEARVSSQQTIRHEISHYPVVLFMKGNASKPACKFSRHALDILKASRVPTIRTVNVLEDPELRAGIKRFSDYPYIPQLYVRGVFIGGLEKLIAMHEDGSLKKCIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D279</accession>
    <name>A0A061D279_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767042.1">
        <property type="nucleotide sequence ID" value="XM_012911588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D279"/>
    <dbReference type="GeneID" id="24563397"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200130"/>
    <dbReference type="OMA" id="SHESTCK"/>
    <dbReference type="OrthoDB" id="366456at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595374" evidence="2">
        <location>
            <begin position="29"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="324" mass="36813" checksum="52E9CF5E7092FF81" modified="2014-09-03" version="1">MCRDADSCLFVLCRTVFLLCPTAPSSLADVFALYAQLLRKWDSHDHVKHRGGTYTDASDFISHLNTDGIDGLFPLWTELHGSYENHKLTRAIASLAGHDHKIHDALSSLSHESTCKSSRGCAPYLQPLGLHAHHTYPQKHAGLYITWILHLAWKFWELLCELLHALDNIDCMASGCATCPCQPGTHGGKDACHCPSLVQCAGSLPTLYRYGFTHRNANLLITDNYATRCGDLNAQLRQTLRSDHFTALFHQIDQLMWHIRMPFLYSFTALWAVVALYIVHTFLYRMDILRIRSHLLTNRVSHLIDVKTLLIPSRKMLTVRRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2D5</accession>
    <name>A0A061D2D5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767112.1">
        <property type="nucleotide sequence ID" value="XM_012911658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2D5"/>
    <dbReference type="GeneID" id="24563467"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200830"/>
    <dbReference type="OMA" id="TIAPKYD"/>
    <dbReference type="OrthoDB" id="366210at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599963" evidence="2">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="184" mass="20249" checksum="F0C6D6B7D60ACD06" modified="2014-09-03" version="1">MFVALTLFRWVLCAQTALLMAAALTHHRSPKPAAEQHAAMVPSYDVFVFPIPSQPEPGTQPRLPTNEENAMTVVEDSQHEDVDNIGEVEQLIREPLPESEIAAERERLQETGELPPGELTVEPPSEDSNGTYYNDGVKETSEILGDTTSNVENDGQGPNEADDEKLKQELEDRLEQLGALSNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2G9</accession>
    <name>A0A061D2G9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0201230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767152.1">
        <property type="nucleotide sequence ID" value="XM_012911698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2G9"/>
    <dbReference type="STRING" id="5866.A0A061D2G9"/>
    <dbReference type="GeneID" id="24563507"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201230"/>
    <dbReference type="OMA" id="MPFCIKA"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="11">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="426" mass="46147" checksum="FE1A805B0DA68617" modified="2014-09-03" version="1">MVFGLFYQIGVRAVPRTAFRRFLHASPRHDKLTTFMLSDIGEGISEVELVRWHKAVGEEVEEMETVCTVQSDKAAVDITSRYTGVVKKLYVDTGNMINIGSPLMDIDAEEHTEVHAAPASADVAKAVPQEPAASSSPTTPNQVFQRNKAGGVSATPAVRQLAKQLGVDLESVHPTGSMGQVTREDVEKLAASKNAGSEVPGKFVKFNSVGRGMVKSMVGSLEVPHVTVGEDLDLTELRAFYREKRAVETDVKLTMTPFLLKGMSLALSASPVMNSKFMGDGYMEYSEHNINVAVATKHGLLVPVIHNVESKTVRELQHDLIRVQRLATEMRLSPEDIRGGTATLSNLGAIGGTYVNARLFGGQGTIVALGAARKQPRYVGDALVPREIAIMGVTADHRHIDGAAIAHFAANLKAILQDLDKMLQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2P7</accession>
    <name>A0A061D2P7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767237.1">
        <property type="nucleotide sequence ID" value="XM_012911783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2P7"/>
    <dbReference type="GeneID" id="24563592"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202080"/>
    <dbReference type="OMA" id="CFCDESE"/>
    <dbReference type="OrthoDB" id="366425at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="292" mass="31712" checksum="6BD062CCA1848BD4" modified="2014-09-03" version="1">MEEDCEVCSCSSGEFESDSSCCSCETCSCDSESRCSCSSPSECSSCSCSPRNAAQPQEVKPNDLEQIKTFIADIAGLIRQSKEVAIKEPPAPEKVPEEPPKAEEPVVVVVEKAEPEEPPAPVAPVQTRDRELQQEIAELERIIHHSEAALRNGYEARPEQPVETPLGGHVPHFAASPCSTGAATAVESPAYYCYTNDHTVGDPFSCAESPISCSAQRTWRSGFEAPAAGEEHCFCDESEAESDTDYSQLDLDQLHAKMVSLDLISYMKLVESVLDERVRLAIAQQGAEELPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Z0</accession>
    <name>A0A061D2Z0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0201400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767169.1">
        <property type="nucleotide sequence ID" value="XM_012911715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Z0"/>
    <dbReference type="STRING" id="5866.A0A061D2Z0"/>
    <dbReference type="GeneID" id="24563524"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201400"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="43227" checksum="9283025A13398A5F" modified="2014-09-03" version="1">MELAFFNANYGYLEGVVRGYRSTFLSPMDYKKMKMAENLDDLRTILEATDYGPVFYDEHGAMNSSMIAKKCNEKLANDFAYLRQQSDGELATFLEFVAREKMIDNLIALLQGVSNKKSPEELMDRIDPIGWFQGIETLMDADLCQSGEDLHRIILCDTPIGKYFEKCLPSLSMGKGNSVLDPSSIALLKSFLKRAWIEDFYYFVTSLGGTTAQVMGHILRTEADFRDLALTLNCVNLSNGSPVVQDRNKLYTSIGYLYPYGTERLCKAYNEATLQQALASYPKYARLYEVCKMSLNRGDSRLTKFDTSERSLEDHFYAESAQLSEECFEQQLHFGIFYAWVKLKQQEIRNIAWIADMILLKRPEQFARVIPVFQPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3U1</accession>
    <name>A0A061D3U1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767562.1">
        <property type="nucleotide sequence ID" value="XM_012912108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3U1"/>
    <dbReference type="GeneID" id="24563917"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205340"/>
    <dbReference type="OMA" id="YEWLWPK"/>
    <dbReference type="OrthoDB" id="360766at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="686" mass="78816" checksum="CF68A4C316F2DA81" modified="2014-09-03" version="1">MNSLCVHGVVAAFILVIYSAEFPTLVISFRLYPTAEGIQFQGFINQARLDIASRDTGSTPLRANGKRTRGRPSGSKGDLDRSSFEQNHERIPTNKPQCEPQNYEKGHMNSYTDPLLAEFGIDLGNMGNDVFDWLWPKPSKGRLKRDRSKSEYIEKGGYLPRNNIMGTSGKSKLFVHQYTHNYNSCIQRYVLYNYAQEKLVDTYKRIAFHMRLSPRLLAREVSAVIGKFGMNILQPTGDEQGRHTAPDVLCLRRTKTRVFCILGRKLLKYHLLLLLRYIRLGIPPEIRERYVRDILTRKNIACASDMICSGIVSHKIALNVEKHLHIQQDMALRLTYPERMDFITQGYPYSSASFLQGDKSGWSPSNLVNEIVYERLSDKSKCKLVYMAAVIHPQYCSQIIKNVVYRAGYKCERDLLLKYCLGFTFCSRGAKAFVSKLKEERISDVYLMKAAQLAMRDKAIRLTSQSLDLLRNVPIVSGLIKRHIESGRKLLPIRTARVIFKRVRSHAELQPEDMILWDVLRETITMRIPNATPYILKQVRMEIFGNETFTDPTLYYCLKNRGIDTSTMDEILKEKGSAIHDMDSAIKFSMANKTRTQLRRAWLDMSDSNKKEMERLGLNIIDAMVVTAGYSSLNNLLVLVTMLSKRSLDQPAKCCQRVHEFERLGRLKLRDFKFSKLDKLITSNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D463</accession>
    <name>A0A061D463_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0205210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767549.1">
        <property type="nucleotide sequence ID" value="XM_012912095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D463"/>
    <dbReference type="GeneID" id="24563904"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205210"/>
    <dbReference type="OMA" id="ANWYNID"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="225" mass="25413" checksum="853D72895A18BF9D" modified="2014-09-03" version="1">MGDFCKYITVFKRFKIAPDKFTVERRVLYPRVTDKLVTVILLCDSPSLGRKGAILSIPRGLANYHMIPQGRAAYANWQNVDIFAKAKDFCINCETGKDEYTSLATAYPELVYDLIRNGTPEDLSTDSDRMANQVLTFKINTLSKDRKRARAPLSLYRILDVFSKRHQIDLLPCHIVGLVHLQGAKMCDKRIPTTGEYNVVARLPLIALHANAVAFTLNLAHLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4C7</accession>
    <name>A0A061D4C7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0205910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767619.1">
        <property type="nucleotide sequence ID" value="XM_012912165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4C7"/>
    <dbReference type="STRING" id="5866.A0A061D4C7"/>
    <dbReference type="GeneID" id="24563974"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205910"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="446" mass="48947" checksum="47F82035ECFD2B6A" modified="2014-09-03" version="1">MFNGVGLTTPRGSGTNGYVQKSLATLRPVRIAKGHDQQGVITRPKLRTNPEIALHEKLRALEVKLLELRVLKEGQMSTEELDKLIANERQRLMKLLEQDSMVYDRRENDSNQLAEDKARRNQKMKEALKIKDTDHGAKPRDVEAEDQGTSLGERDEIDQRAHLTVRIVGTWKGAHRDQARHIANVDTSKSTNVQAGLTPPTAMCPAALTQHVDKDTDAYAAFPTQDRVHTAVRPANATPIDPPTEAPNETECGAGNVHVAIGAQAVVTGKEGVQGINLTAALAVVCLAGHRPVDRTAMPHTTARYRAVIRRNIAKVTVAGVKGIGMLSQRGTKQYIRIVADHDQTELALEVTKSNADAATQADTEDRYSSRKCRRSSSSSVSSSPSPHETRRAELRHRDSRKSKSSSRSRSRTHDRHSRSLSRAPGNYERNDGGSATDSSMEHSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4K4</accession>
    <name>A0A061D4K4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767837.1">
        <property type="nucleotide sequence ID" value="XM_012912383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4K4"/>
    <dbReference type="GeneID" id="24564192"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208050"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="75" mass="8163" checksum="928ECC6465506385" modified="2014-09-03" version="1">MKCSGGISNTITAESKNIGHTFVILIFISGLQKAALNEYFTSTNAYYIQSTHYGVSSDNQESNESKRPRAAETVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4N8</accession>
    <name>A0A061D4N8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GCC2 and GCC3 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0208300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767862.1">
        <property type="nucleotide sequence ID" value="XM_012912408.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D4N8"/>
    <dbReference type="GeneID" id="24564217"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208300"/>
    <dbReference type="OMA" id="CIFIQGS"/>
    <dbReference type="OrthoDB" id="410989at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF5">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600048" evidence="2">
        <location>
            <begin position="19"/>
            <end position="3014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2180"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2210"/>
            <end position="2231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2301"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2459"/>
            <end position="2480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2537"/>
            <end position="2557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2595"/>
            <end position="2617"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="3">
        <location>
            <begin position="1460"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="3">
        <location>
            <begin position="1576"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="3">
        <location>
            <begin position="1816"/>
            <end position="1855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="3014" mass="338147" checksum="00B91948CA192FE8" modified="2014-09-03" version="1">MLACKLIIFALFGRFAVAEYSTSWLAALGFLPGREVTLAPQRNADPYTDDKVSWCVMGMSCSLKEDVDKSYSKMSLIVSRSVAHPTNHPYYTAYIVKGKDPNAARSRVIALYNGPETTVSTDRDRTIKQNQISLRYTSQAYNGSHPLSGLANYGNEMLHIVFTRYTYSSKNYEQLAKFYLMKAPSDVSYQVDINGEVRVVMKDFAPGPLIFLGCNLSRVRFPQRFLLIMPTVSCGADRVAVGQIGPVYEMLPRADIFYLYMFIIPQRSEDMGGEIGRISLCNPHKVKRIEVEVEKESLTVSVYGINIEDYRATFAILSVTNIYGTQTACGATDAEWYHLDLKVTYRGIKKADYFFEFDVPLQYAGERVLLCGTLGRNTSNIATYTMPVRHLTLTKEPFIGSFSLINVDALGRASIASRRRMHPMSEMRLSKADDSVLARGISYEYDKLAELVLPFERTLAYDLGVMDKLGDTALSPSAILRRVQSYSSLPSNSARYLAFPPAISHRVGNKSYWSTKVHFFPKLLLSVDTVYKITACDRWRHPFCLSESDFDTDVGYLLPNPFVHSRFKAKWEDGTIVLFLSTSAYYPVVPHIILVKMNVGSIIDYDMLCNRSPSIPVQCIISGRMRDNKGGKQAPKNAVEMLFTHRYEVVGLEAGYNYALCYSFEGRRHMSHGDPTSAKILSNSRPPVHAQFTFLTTLNPYEIERNQRTTYRSKGDKDGPVFSTRGLLESIKVRAVYMSEDLKYDCSNIYSHLSKAPSQKRVHVELKPKTTESLFWLRTQKEAVAPKTVVPLPLGFWLKMDNKFWKYKSSRLNYNDVIEGTKSLYKVCVCYEDHCTSVGNMAYSQDRIFDITSISQASMLSRIVVGKKVCVYGGRDLRCYDNTGSLKSMLTTPIKFKSLKGVISCVLFRHSDNAMLVVKDYELLIYDADFKTRSVVSIPTGIDKIFSFPKITFVALVDGFVYFIKSDQALDIKTTAKELTEDAEEGITLAEMDHTAIPQDISPDGLSDDSVSLRPAFLSEGTLLDDTNGETPEQTESATFLKVSESTMVKLLGASGRILRLEIIPSEDEGSYRLFYIDESLMLHYSIGTLAEDAGVVRMDTKILYSVSITAFLDIPQDRYLTLKAFPARSAEVAATSVLVHSYGYPKVATFLVTGNKLEFYGHMSTTSKLVDFAVNKDRLVGLTLEISPKGEISQSLVEVKFSSIMKTTLNYTNIPPTLRLGVEYSFEPTTLPYRLLHYSTQHVDIFKQLGLNLDARTGRIYGTPQTYGNFTVKVKGEGLFSSTFVEQYLVVACSVGHMYDSSTKQCKPCDVGTYWEDDASHGSCKPCNEFMKNSSTKEAGSISTASCICKPGWFLKDRECHACPQGSTSAVYGSLTCPIVGYIGEDGRVISGAESLVVTCERGEYLKGDKCLPCEVGSYCHGGNAQPIRCSAGMTTEKPGAGAYTDCMCNAGYEWVGGRCIACSRTSYKEEIGNTRCTRCRTAASASGVLYTPHVGATSRRQCEYCNEGFYHDVNKVSCVPCPVDSYCAGSGTIPVFCPSNTVTNGTNASSRNDCLCAKGYGYGTATRFIMSYDNACTSCPINTFQHINGAGTQCLPCPRNTYTASIGAASLGECLPEPGYYSPYGRSVKGVISQLESIDFKTLGSSSFVKCSADVRFDAPFSITVMTRSLLSCVDLCRNNVYCRYVHYGERLGGMQHTEPQLVAYSSKVYHPCKLIMSYERFHVPDLSAHSFKVMDRKTHRYNVLCEIERPKLASIPNVFSVLKCPMNYYCPGGEKFSSFRCPENSMTLTTGAYHSGHCLCMPGFELSNSASISSCVPCKEGFYKESMSNAPCTACPAKMTTFGKGAVSATQCVCSVGFFAYPSSEKPQATLPALVPTSGLPMVRNASVLTDFVIATFNYFGSTNSTDALKNFECNACPEGYVCPGKWLPHMAFTIHHPPISCPYGSSVPYVSHNVNSVGKCMCKPGYGSGNAFGDGIVLSCRKCARGTFSETFNTSTCAGRCNDYATTFPGAKSAKDCFCLPGRFMTLQMIDGENKFVCKKCSEGIICPGGFRHRDASVQISDDPNTAIFSHSPQYPRMGYMAIYKQHGTQSADEVKWMPHKHETYILNPPTPSQLGLYEHVPDIHPCIYPNRCNGSGGNLCVDGTHGYLCGKCKPGYDTRYFQSRCFKCLNVFIESFRLILPRVILPLIVFLICQVNNGILFSGNFSLIVLFKIWYMFTFSLVPLGMMQLTTSSSLGRFYNLYHNYFYKMIGLFMTIERVGCWEPWIRRILVVLNRWGFGLIKVNPDQEMEYIHLWYIQRAVVIAKPLVDLLVLCMLYYPCRSIRKFVVFKLFGESQTNAMDSRIDSLLKMAESGDSVVEGGAEEGIVSLESLEKPSDKDSTRDVYVKSRKAENVFLLQQMLFLLVLHMPGSVINSLSMLWCTPVRYKEGDMVYILMHLPEQVCDPNDRLFRYGWLVGAVNILLWFTMLVALFFMLSRSHYTPRSWNTLFMAGCDVNCRWWDVVQLSRQALLCCLIVCHYSIDPKGDTEYMRVTCYLILHFIYLTLHLCFSPYDYRNNGSFNHLETTVLLGNLCMCIFIQGSFMYDFSDLAGFPIVVSLLVHIKIMWAIAVEYGNIKFANIKRNGKKEFTNMVLDFLPSVFEHRNANVYYDYKNDNIVLEAAETRIKNRGFYNRLIKRPLLKFANFVGLTSKRPEESASCCYSLKNRDFLIMCIHATIQKCNMDRGTIALPNAWFYFVTSYVFWYCHCLHSDLHDSNLSNNAYFHKLVFCHFFPQDNMSDESLANFLVKFPIRRLSSHRSVHHNGKACDGKCEIMSGDKKKWRKVEEVAESLLVECLFDTLYDLGPVTLIEFYYGLLSLNQLRNSVVFRLFEGFRIHALFLKDEKEFQLCREADDLNETISNLKYGISQKGEMGVMALQRYELSLQLDDIDLSISELEANIDRQRNVIMAGRAAAAVALNLHLGVDNIVSNDLNHDDILAAISSTPHGSAHANNMQRRKGILAPTYKLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4P7</accession>
    <name>A0A061D4P7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767208.1">
        <property type="nucleotide sequence ID" value="XM_012911754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4P7"/>
    <dbReference type="GeneID" id="24563563"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201790"/>
    <dbReference type="OrthoDB" id="10406806at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="141" mass="14862" checksum="80D2FEED36C14865" modified="2014-09-03" version="1">MDPPDAEPNGAAEAAASALADELQSLDSASHHSASIEPGELSARRASISSTPSLDGSSRGNEVPCINIPGDHNVEHNPWEGPEGTSSATPQDEDNPATSDVMKYGMEGLLEALKKYPSTHPPIVSQDGVNEELLRHRLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D502</accession>
    <name>A0A061D502_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0209195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767952.1">
        <property type="nucleotide sequence ID" value="XM_012912498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D502"/>
    <dbReference type="STRING" id="5866.A0A061D502"/>
    <dbReference type="GeneID" id="24564307"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209195"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209195"/>
    <dbReference type="OMA" id="ENVNCVQ"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="715"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="775" mass="86902" checksum="2D9CDCB58CAE0B37" modified="2014-09-03" version="1">MNILNALEQRRRAFGVGCGRRVVQVSLDEPGVPLASFIAKKLKPYSRLHVHSGCVNRLRWHNDGKTLASVSDDLTIALTNVHDVDPDSEGDGGLRAFRTSVIPTQHVGNIFGVSFLAGGRRIATGARDSRVCISDVVERQTVHCYRCHSGSVKHIINDGLTDFVFYSGSYDGTVRQFDIREPHSCDGHCRNIIVALGRGIDHNPRGVRRRKCSWADAISEVDRSAMQNWVDLAYAEAAWANQSYDGTEVKAIAINPVQSEQLAIAASDSMVRIFDRRKLSMGHAYNDGISVNYTMPILEEIYMPKHFKNDETRLFATYLAWSPDGERLAVTYESEHVYLFDRNFTSVGAINTGHPGTCEFQDTCGNNRTTARIRELESHYAVCRDKACAQRNVSQLLYLLLYRNHVGDAALCESIAKEAFLADPANALLLFRRVQASLLLDNYYMARRLCFRGARLFPDHAAHFNKIRRLCLLLLNEKIREIAAEEITSLLKSICTARAITSPNTDIYAEHTIENIANEGGESDDEMHVSIGASFRYSISGWRRWPHPETCIRLEEHLRGAEGKLEFEDSPSQSEAESDGEIAEVEYQHEVDIDEEHSMVYQLRSAADFSPRERRWNMHHYVCFDADEGGAHPHRPAYPYESYPIPYVPEHDLYRAIENPSWRPAGNCRRLCGHCNFGTDIAEVNFWGNDVIVSGSADGAVYLYDVKSGRILDILNGHGENVNCVQVNQQGTLLATSGIDHYIQVWRPSGDFNGITVSAQAKPPHDHTASAGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D572</accession>
    <name>A0A061D572_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766305.1">
        <property type="nucleotide sequence ID" value="XM_012910851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D572"/>
    <dbReference type="GeneID" id="24562660"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104280"/>
    <dbReference type="OrthoDB" id="10408332at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="85" mass="9903" checksum="07C8794B7080FB12" modified="2014-09-03" version="1">MTICSIFRRLVANVAAAQTEPLSKVKQELSRQAAELREQLRLDAMARYAKRLARKEANIAAPRPVYEGPRNVRYWMTRRRSGMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5A4</accession>
    <name>A0A061D5A4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0104580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766335.1">
        <property type="nucleotide sequence ID" value="XM_012910881.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D5A4"/>
    <dbReference type="GeneID" id="24562690"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104580"/>
    <dbReference type="OMA" id="HIPTCTP"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1278"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="497"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="908"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1300" mass="146171" checksum="E919B952DC94D228" modified="2014-09-03" version="1">MAAVKYLIKVEVHEVKEVVFKDPSSEVDIIPNLYCLVTVGNTQYSTIQKNQASNAVFNASFNFTLDLTPTELSRTRIIVSLHHKYRIQSALIGLHAFGLHYIYSKQQHCIHRSWARVLCPDFPGHNAGLLLTSVGVFGPGDNVPLFKEGVGGTRPTGAIIAAADVGQGGARNLRSPEIASKFYVLNLNVICGRDFMSRGSLLSTCLEPFVRVCHGGLQVQTPVIKDNPNPEWQSTLYMPCLTPSFDDLLTVEIWNGESNSVLLHCESIDVKYLFNNDYPPRWVNIYCNNASTSGLLDLVKTYVVGSNECLTDYGGRVLISASATQVQVPPVVGIKPFKQISAPPTQKRIVWIDIYEVVPLANSTVPIEVVVCLGPYSVRTAVLRLGANGTYKVDDTVGRLAPMEPLVSGLNSSRSRQFFVGSNDSDFWDFFVYVNDRSEWGITEQPRVAWKRISYDLIRRSQGKPMWFLMPSVADPRIDAFNMLMSIEVIGDEVEQRPGRFEYTLSKYVFRAMIYEALNIPCLGMAGFPDSFVEIELGGFHIRTQVARGTLCPSFYEATEVEVLLPSNLVLAPDVTINIYAEPTSMFASRELLCNGHFSLTKVPKEWRKAPQWVQLKSTKNDLHHPCVLVAFELVPTDILLKDPDLYPFFDDIRPSKIASLVSLLLIGVRAFRPLNRPRVLIRFGSRDNPIYKSSSGNPVSGSEGNWNYLTTHSLMVDLPKRMQHHCYIEFVVITGDNECFGVTYVSLNAFLPWLTHEERLHSKDIFKMQVLEDFLSTGEQTHIDESKNESGSSKSVVREDIESQNVKIYETFDFVSLQRAGESRDGEEFRNDFDIAVVEDDEPDDLQRDEIPYEMECDFALEDLPYMKAPIVQCTPAGVPETVGVLKYMCSVDANDNKDVRREAAAKMAERRQKLVDLYAKAKELVVRLYVLQAKGLYTSSGHSNIPTYLWVRNSDGEQKSSLSYPQNIRDTTIRAQGVKPVFNVCFNLGCALPENSILKISVVEQGTIQDEVIGTTFVDCEDRFLNQKMQQLMVQDIVPIELRTLKNEDSTVSHGTLRCWIEMMDLDTAQTKPIRTLGGMEQSDYELRVVIWDLRGVPLDGNSALSLFVRGTYQVEEGEDLVEETDTHYNSRDGTAVFNWRFKYPIRIPSDYSLLKLQICSSNLLGGNELIGESAIDLRQDYSRIRKKVGPYHCKKFWLDCLHPSFGSQSRGQIGIEFSVLSDSEAKLFAVGKGREAPNKDPFLPNVLENRTYLDWQEIKATINNASGAIMSGLKWTGMFITIAFVFASLLLILVAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5F4</accession>
    <name>A0A061D5F4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0105080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766385.1">
        <property type="nucleotide sequence ID" value="XM_012910931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5F4"/>
    <dbReference type="STRING" id="5866.A0A061D5F4"/>
    <dbReference type="GeneID" id="24562740"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105080"/>
    <dbReference type="OMA" id="CSDIDTR"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="9">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="9">
        <location>
            <begin position="327"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="550" mass="62996" checksum="DB7AA2CCA780515A" modified="2014-09-03" version="1">MAEEKTYTVYSDGVFDMPHLGHMRQLEQAKKMFPKCTLKVGVTDDEETLQLKGQIVNTMSERAEFLRHVRWVDEVIAPCPWIVTKQFMTSHGIDFVAHDDIPYSTCQKATKGIQEASEHDIYGWLKEEGRFKATQRTAGVCTTDLVVRILQNYEDYVERSINTGVNPSDLNIGATMANSIRVKKKLNKWVRQLADQITSTDISLGHKLEEKLEEIRAGITTSLEQWIERYITALREFVGEGSGVDNDANCDSVRMEDEFLDVYSGKDLSSNTDEFVDLTPTKTSVYYTGDDFVDANGNKDGFEKLGMTSITDDYDDDNDTREDIVVYTAGVFDLLHYGHGRHFEQIKKCFNKVHLIVGVVSDDVAVNLKGRVMQPCKDRAAALQHIRWVDEILEAPPTPITQRFLRKYHIDYVVSSPNVEYDPEALRWLKENGRIVYTHRTPGISTSNIMLRILRNYETYIKRSLERGVGREDLKIGFTTANSIKLKSSIENWKKKFTQEVHKATLTDHPVGHEFDLLVDKIIEVVDGWRKDSQAIIDNFIKCTMWPRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5K1</accession>
    <name>A0A061D5K1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside monophosphate kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0105480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766425.1">
        <property type="nucleotide sequence ID" value="XM_012910971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5K1"/>
    <dbReference type="STRING" id="5866.A0A061D5K1"/>
    <dbReference type="GeneID" id="24562780"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105480"/>
    <dbReference type="OMA" id="SCTMLIC"/>
    <dbReference type="OrthoDB" id="366023at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600625" evidence="5">
        <location>
            <begin position="26"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="238" mass="26710" checksum="D96A1DE330E243FE" modified="2014-09-03" version="1">MIRARVTGVHRLLLLLLGAPGTGKGTFGRHLASEYGLVHIAIGDLLRKQIRLRSVLGSSIQRAVSNGFHVDDDIVCDLVRIELFSQSKGAILDGIPRTPVQAEFLKNIAKSSGSRLLGVYLSMDRGILIKRLLGRRHCEMCNRNYNTCSIDSNGYYMDAVLPCEDDLLKCPGCHHLKRRADDTADVIQRRLLDYDNMRENIMTALKEVPIMSFEIRRGLKDYGALKCELDAFMKNAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D689</accession>
    <name>A0A061D689_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767718.1">
        <property type="nucleotide sequence ID" value="XM_012912264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D689"/>
    <dbReference type="GeneID" id="24564073"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206900"/>
    <dbReference type="OMA" id="IPIHYFD"/>
    <dbReference type="OrthoDB" id="417952at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595825" evidence="2">
        <location>
            <begin position="24"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="592" mass="65569" checksum="91C8C377230D614F" modified="2014-09-03" version="1">MRTTRRCLLVLAAVTVIAQLVEVVQPFMQREAALYRAIASRNAAAKSSARPLRKQRPPAKRKRRGGRVIATIHDNHARDTGSQEHVGEPATVNIGLHEGTVSPSQEAEPGNQNEVATHNDPNDGDNTDESACEGSMLYGGMPEEAMPSGGTDDSGGGSNLHNRLIEGTEYQLHIPPIANFKPQMRLAFTKPEVYAQHVPEEPMDTTNGEYAKGPLQLHEMPALGQIPEFRHSSDVNGITPGKSELFTWKVERPPDVFIINWSGVAHTGFRDGVVVAARAILDFTGEQPLDVQQFLESVAERRSLPIWLATRARYAQPFLDSAADWIPALQHFINNCNDQDMLEKVHTVEALAATDANPLDILKHITVGGDPNELVDLGSPQRESMGIEAFELEGWKADGARYSDMVSTYDKILKQLGIDKCSLDQHFQDAWSKLCADREAWLDTVLYRTNCAALDAAQRRNHESYNCAVVGAIKHHLEVFQMPVYLVSDVKTTAMVMSELESLQIKPLHAGDVYGRDRGTPTDSVRALLADLQLDPRVPVHYFDDRLATLDAINSSDDLRHVRTYFVDWGRSTLSEKLGSLYADRLAALCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6B0</accession>
    <name>A0A061D6B0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768412.1">
        <property type="nucleotide sequence ID" value="XM_012912958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6B0"/>
    <dbReference type="STRING" id="5866.A0A061D6B0"/>
    <dbReference type="GeneID" id="24564767"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301305"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301305"/>
    <dbReference type="OMA" id="FAFIWIM"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19513" checksum="0ED53EB8910EE02B" modified="2014-09-03" version="1">MFVGDCQDSREETTAVGAKLLYVIGKSCYTHKGEKLLNWDLFGPFVISLLFPLVVYLPIAGDHNGTQSVAFSLFFLFIWLLAFIAALNASLVGTYLGCLPTVSIVIYGIFPICLASIPSKFLPFFARVIVVSAATIYALLVSKKTLEAHVVKDRWVMAYQPIVFMYITAGVLIVFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6C6</accession>
    <name>A0A061D6C6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768294.1">
        <property type="nucleotide sequence ID" value="XM_012912840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6C6"/>
    <dbReference type="GeneID" id="24564649"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300130"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7503" checksum="1F9645483116C330" modified="2014-09-03" version="1">MPCLKQPRSDPGTTALHLECGHYDRETVPIRTVTIIAVNESAGASWLLARRLLGHGGFSLKRSAYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6I5</accession>
    <name>A0A061D6I5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766735.1">
        <property type="nucleotide sequence ID" value="XM_012911281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6I5"/>
    <dbReference type="GeneID" id="24563090"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108470"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="65" mass="7459" checksum="51177253E0CF29AE" modified="2014-09-03" version="1">MQLMFKVLAENLFVWFQKQYPNRTPIWAIPINANISAERILFKNVSTNANVRADALIMQGATDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6L4</accession>
    <name>A0A061D6L4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767848.1">
        <property type="nucleotide sequence ID" value="XM_012912394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6L4"/>
    <dbReference type="STRING" id="5866.A0A061D6L4"/>
    <dbReference type="GeneID" id="24564203"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208160"/>
    <dbReference type="OMA" id="GKHEASI"/>
    <dbReference type="OrthoDB" id="5395246at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="153" mass="17242" checksum="BC9FD5A630096ABA" modified="2014-09-03" version="1">MILPQVHLRKPCSQNFPRQNRRIGKATVRIIHRITRSVGATGGVYKGQGQLQKSIPDTMHTKDYPTLSGQDKLDGCISVARVQPRTSKGITDLSPSKKQTRTKSKQLVSRLRSRSLTELTRQITPPTKNGHAPPPKESRKSYQSVNPYSVWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6X3</accession>
    <name>A0A061D6X3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768637.1">
        <property type="nucleotide sequence ID" value="XM_012913183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6X3"/>
    <dbReference type="GeneID" id="24564992"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303550"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595509" evidence="1">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="153" mass="18012" checksum="5B9298366C0AF218" modified="2014-09-03" version="1">MGRELHSMVFRAEAMLLRLWLTFSADEVTSTRRAAIMQHFRDTYAYISHIKMHLEGRYGMEFGVEYTTYKSVRDLRLAQNKWLYNRKHVKSTHKVLYAKREDPKLDIEVSSLYLTCGILILEDNAKAAELQDRNLQWMISSKKCTTFNNAKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D758</accession>
    <name>A0A061D758_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S RIBOSOMAL PROTEIN S17, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302550</name>
        <name evidence="5" type="ORF">BBBOND_0302670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768537.1">
        <property type="nucleotide sequence ID" value="XM_012913083.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768549.1">
        <property type="nucleotide sequence ID" value="XM_012913095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D758"/>
    <dbReference type="STRING" id="5866.A0A061D758"/>
    <dbReference type="GeneID" id="24564892"/>
    <dbReference type="GeneID" id="24564904"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302550"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302670"/>
    <dbReference type="OMA" id="MKRIQQG"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="132" mass="15373" checksum="00656564B74C4DE5" modified="2014-09-03" version="1">MGRVRTKTVKRAARQIVEKYYAKLGLDFHFNKKVAEEVAQIPSKRMRNKVAGFITHLMRRIQKGPVRGISLKLQEEERERRMDYVPEHSEVDVPLIQIDQDTADMLHFLKINIPNVKVITANVHGEGAHQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7B4</accession>
    <name>A0A061D7B4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768787.1">
        <property type="nucleotide sequence ID" value="XM_012913333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7B4"/>
    <dbReference type="STRING" id="5866.A0A061D7B4"/>
    <dbReference type="GeneID" id="24565142"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305040"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7467" checksum="ED73FA24832C5FA1" modified="2014-09-03" version="1">MTHLYHDPPPLPNLQPLDPIGPATADVSVNFPPIDNPESLPNSYVDPYMHDAQAVGMCIAPWMKQAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7D2</accession>
    <name>A0A061D7D2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0210400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768073.1">
        <property type="nucleotide sequence ID" value="XM_012912619.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7D2"/>
    <dbReference type="GeneID" id="24564428"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210400"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="577"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="754"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="882"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1352" mass="152216" checksum="0E5B7555DE8EBDBF" modified="2014-09-03" version="1">MRLLWDDSDSDSDLETICVTDTPRSDVADPSEIDSHESSPQAINNAVERGTLALSEPPGISPFASAENFGMVVALELHNFKSYRGTVRICEFKKFTAIIGPNGCGKSNLMDAISFVLCVSSTVLRGLNSKDLIYKPGDASAEPVAEAYVALTLNGATRHVVFKRHISHAGAVTYFVDATSVSFKQYKESLREYRINTLGSTGLIFQGAVNDIASRSPVELTRLFETISGSSLYAKPYSYIKEKLERKRVECRDLASRKRTLQQELRQYRSMVTKGIDYDEVLSQYKRAEARKHACEFRLHEVKFSAHKSEYLQLCQRAAELNERWSTMQAKRDELERQRAALYFEQGQLHRTIQDKQRAVLSKKESMSEYYEQKSSLEQRISEFDSLRQSIEKDVDNLRREHEELCSQENQLCDDIDVLTAELEGLSTTLSLTPAQRQKYESLLQSFNKITSSLRVKLNIGRGKLTALSSDADNIRAELDLLNKYHAKLVEAAKPHAGMYDSLCTRLRETQDSLELLSMTQSRLEHERSQVSSRRAALQEEKTALDENLKTLNVAKVEYRQILRRRNYTQELVSAIPGVHGEVISLCEITNACYHDGIMAALNTRSHMIVTDDMSAIKACIKKLCSDRVHKRDFLPLDSLKQSKLDHRKRISDLLRMRGVRVQYTFAIDCLVFQRQYGSLFEHLVGDTVVVQSLDDAEVLISADMGHSMSFNVVTQKGQVITRDRTIILDSAVYTKKSHLELELAEFGRLTLKSERLDQDIHVLTKKLTGIENELQDTIGRIQKHRRAAELLKMKVDFAQRQKQASDQQLRNSETKLGAVRLRLSAAQDEVDKMRAELAKDEAVLLGLQQNHFEDLNEELGVDVYGVMNSRQDSAVRVESYLERKRALLTRCERDKVEIENRIEDLRESVLADVVAQHQSALAELHALLKGNQSLYRELDELESDLGKDREKFDSLSREIEKCHERIKFVQYDCDYGIDNADPSQGDTTTDVDDATGGDIVMLSEDDGYVAGPRDNGRNATTGRVVPLSESKEAVAAQLLSLVGTMRDLQRQAIKLVEECRLRNVECKIEVPESLVTTSSDFVPDFPRLVNTDLIEGVASSESGLEDFIKRLEDQMHSLRKSLGASRACDDAEVRLKRTQVDIDHLDTEMASAKSECTSLESDFERIKKERTSLFMNCFQSVKALVGPIYRSLSARDDTDEMSGGSAFLTLDDDVSGSVSEPFLCSIRYNTMPPMKKFLDLSLQSGGERAVSSLALLLALHSFRRSPFVVFDEIDANLDNVKVHSLVSFLQRSAFQVIIISLKAPLFSRADMLVGVYSRHESASSNCVVLNLEEYGCSSEGDSAIAANGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7E3</accession>
    <name>A0A061D7E3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768817.1">
        <property type="nucleotide sequence ID" value="XM_012913363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7E3"/>
    <dbReference type="GeneID" id="24565172"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305340"/>
    <dbReference type="OrthoDB" id="366456at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="564" mass="63369" checksum="DE06020C027ECA59" modified="2014-09-03" version="1">MRNARDRRCHDGDIPNKEDAIMAKCIEGLPFTIRETCSHSTALLTAIQGNGHGFDLAAYPYSVDFSNNRARLRYPADPDALLDMLCEMVCRLCKVLYFLYSQCCRSTARVKGWRECAYGRQVQSHHWQCHIFDTESTTTTSGATTTTTSSTTSHGCPPTSPLQSFLSDRCNGLLPHTLTIADMVIECANCTSNQLGQQCLTPLGFWDLGFAASISGTGWDLARRLGDMCRDADSCLFVLYRTLFFLCPAAPSSLADVFALYAQLLRKWDSHDHLKHRGGTYTDASDLISHLNSDGIDGLFPLWTQLHGSYQNPKLTSAIVSLAGHDHESHGALSSLFNDSTCKSPRGCAPYLQPLGLHARHTYPQKHAGLYITWILHLAWQFWELLYNVLHALGNIDCTASGCATCPCQPGTHGGKDTCHCLSTVQCAGLLPTLYRYGFTYRNANLLVTDNRAIRCGDLNAQLKKALQSDHFTELFRQIDQITWHIRMPFLYFLIALWSLVALYILHTFLYRMDVLYIRSHLIRTKASHIIDVKALLIPSRKMLSLYKDVDYFEDDPDELLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N2</accession>
    <name>A0A061D7N2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768739.1">
        <property type="nucleotide sequence ID" value="XM_012913285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565094"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304560"/>
    <dbReference type="OrthoDB" id="366777at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1649"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="741"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1711" mass="191026" checksum="BB2376F7D0B4C902" modified="2014-09-03" version="1">MAPKKLTDCPENLREAIDWLIQVRHGNGGDGQGLKNLAEALKRLIEEAISNAYDSLNKQYLLAKPPSTVASASSTTKPTGSATPEKKSFADIKKDIEKQVEELPTNISELQKESANDPPRGEEATKLSAKLQALKTVKKLAEFAEQLDTKKHPNNNILTHLCDGLEKFLGFDPTSKGYTGKGIVYSDLDRLCDGVMAFLLSCLEGSKDLLTHYNRNTTHVIGHLKSSIGKGSGVSGFASAIEKVKEGLQGYERELNTRSDKVADDVTLIYRLSGKYKADMESSDFLNKDITRQINDIKQKAQFLWNAAAGAGNDTDLLDHGLQLKLKIAVDRVKQAVNVLKDVSNNDHVMGQAAIVDRELVAKNREIVQLIESQTHNVRKALGEGFGNIVVKIDELGEVKGKQIQSVKHKVNDAKDSVGELLGDFQEGYKSVIERLFSELKDYMNNINRNTPHGSQGRSFLKEEFTAVTSAVEEIEAAYQGKLIEVKADVERAVGRVLIHLTQVDGSVRHGLLDIRNKIKQNLVDFCNQVGNNIKDAAKKAGTNVYDTNYPAVKALGTQLQNTLQRFGSTITELTNGGSNGIATCLQALLYYIDNPPSATAIYADLVASIRRSIEEAIDAQLKKVIQDAGSLTFGQNLMNEYNEETKEEGALSNRLRKKIEEIKKHVGYMKLGDAEVDVESFLGYKHTEARKNDNKGAKPRYENYIRIVLDKIDDLEALPSAVDEAKNVALKKTDELIMQIETLKSDIEMIEKAVQKADERMTMAIEALSNAYTEAERKCRQTVDQFREKLLETVRSTFRQIKTSVQSLFAKQKQAELATLENVIQLQLDEIKRVIQEDRENDLKGYWRKLNTGLKKHLDIPSNSPDLINSTTLKMLAPSVLGFLDDVLDYVFKQVQKSSLPSSSLSYPTIVDGIKNNLNILLGTLSCFNKTSSDHIEALKKPLASLVPDKFDGHNNHLLDLIRDGVKGFVEQLEYAYISVYSEATIKWKSTTLPDALASAEDALTENAMKCAKVFLTNIHTLHSELSELKDKCEKDWTDKQINLVATQRVVNGRSQNMTNSLGDFLKRCGFDVSTGPHVCNAELANKRNMIGSDVFNLLVVHGSVFIRQTTDDGTADESVMYKVLKHLHDYYKTCHLGNNKSTKHPSTVRDMLHWLCGLFHNPVLGKVELYFKELFQKPDALKDVPYDAIDATKLRLSGTTTIQPHYLTTELYKVCSHSEKVLIAILGYGHAGGRYACEYNTNPDNLDYPTDPSKCFDWLVEVLVRLHHQLSFLYHQCCNGTSSSGWLDCLYGKDVGGSSWRCNELKCTEPSCGITCKRHPRCGMKSPLQSFLEDGLPGFLPHKFEKPDCKITCSLVNHHGIPCKTPMGFADISTVASHTAKGQHLMKVLAGFCSKSDRPLTKLCSYLVCVLQRPPQTLDEMYAFYYNFIYGWGDLQNSEHKSNAFNRAVNEASFNRGITLDVTQIADRTAHGEHHVRGDLFSLVSCNDRSSPVSPCGPYLHPLSLNVRCIYSKEHADKYLSWIVYLTETFYNALCRLLSKCEAKCGANISKCRSERCASDCQMLKSATHSSSCQSILECPHTFPGLYTEGIVFGSTTKLGGRIGNPWKRSCGDFIDQLKKVCRGKTILAEYVHIIIPYYLYKIRAPFIWTTVALWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVKALNKVLYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T1</accession>
    <name>A0A061D7T1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0201210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767150.1">
        <property type="nucleotide sequence ID" value="XM_012911696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7T1"/>
    <dbReference type="GeneID" id="24563505"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201210"/>
    <dbReference type="OMA" id="YIWIKAN"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="TLDc" evidence="8">
        <location>
            <begin position="713"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="884" mass="99375" checksum="64DFFBEBB0D6E257" modified="2014-09-03" version="1">MIPAAPDGTQLVDTETYKQWRSAEINELELCVWSADMFKYGIAASYESYGSLKTAIRRGVPDLIKQYIWIKANGADRFYVEHPNFYKHSFTTTFGQNVPEVMGEDCPTFCGGISGLQSDVLGTPIRAKDIDFNATSLDADGLSDTVFQWHRRSQHESDGGSGYDTDEESPLTRELSVSSLRENYSRRKPGRSHRSAAYADDDSTPHVRFDVDVWRDLSALPLPDVSEDAPEVDRRDPLDHYLSVLHAENSNQMMLLKEAKKKIRERQVSLSEVSSGGNMQRQFSDTSLLSSGLTLPNPPSHYPKIVHNQLPLAHKGSMSQVCPRTSTIIRFLRQREQRPVLASVDVSIPRRCRFLDFCARMGLLCGARRSRRSMYVDWSSSNSETAHGVGHLPSDTLSDQSGFSYENTGGDVTRTTLADGNFQQANDSIGTTGTFQASSNEPNSTDGGYIRFPSTAGDTMLVRQATTKVFHSSVYKLSDITDYTALLTPSGVNEVKRILWCLNTSFSATIEFLPVIPSLCCLLLVYMAPDIALCVLHCLMVRAVESARLECGERFLFVDREGFVDFVKYVLNVMRYHMRKLVAKLQLLNVDVAAWIARSVQSGFSHVLPFDHALRIYGDFLFEGEIVLCRYCIALIKHGHDTLMKCNTQHEAEEALYNIGLDNTLDVDQLTKLAYSFRLKYYKSEVKGDPVTPYLMPVKIRAFYRPRLCSLSRIVREHKWETIWSWLLPRYRILDPRMFYSSDRHGTSMLGLVKALEDSGRSGVASLLFIETTTRDILGVFIPTLNCEAAEGLFTSPHQSDQLDSFVFTLKPQEHIYKWSGLNTTGVKISSHQIVVGSDHPALLLDKAMSTGVSQACASYNSPKLVTTQNGYFDVSNIELWHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U9</accession>
    <name>A0A061D7U9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768804.1">
        <property type="nucleotide sequence ID" value="XM_012913350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7U9"/>
    <dbReference type="GeneID" id="24565159"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305210"/>
    <dbReference type="OMA" id="MEAPVIY"/>
    <dbReference type="OrthoDB" id="361916at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600673" evidence="2">
        <location>
            <begin position="20"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="304" mass="34694" checksum="8F9AC899A6367F0C" modified="2014-09-03" version="1">MARLVACVYLFLLPVCVLGSDVASEGNDRDNRLEEFPEAMDASELKRAREVAAKDDEIYMSLEDQAKMLDTIAEELAMMNESSDDISYEDMQLFPPGGWDQGDMMYSSKYRLPRRKQRRSDASIDKMEAPVIYLTPPVELPDEQMEADKEVEKLLMDTGLEDKPHSLPEDDFDPFTLTSMDEVMTAMKKTKSTIDTLREKRTALLKTLRESSMYVATDHSKMLTYKAVNQELDEVDNIIEKETTTLLKLEHVKRTLSRNHGAGRDVENEEAKLEKREEEIAEGYATDADSDAESDKEDNSNDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D811</accession>
    <name>A0A061D811_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0202210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767250.1">
        <property type="nucleotide sequence ID" value="XM_012911796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D811"/>
    <dbReference type="STRING" id="5866.A0A061D811"/>
    <dbReference type="GeneID" id="24563605"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202210"/>
    <dbReference type="OMA" id="AWINDKG"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000085">
        <property type="entry name" value="Tyrosine--tRNA ligase 1 cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000103">
        <property type="entry name" value="tyrosine--tRNA ligase 1, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="415" mass="46767" checksum="5C92E0A28E41C60F" modified="2014-09-03" version="1">MSRVFASPLHGGLEFDGEEECYKTSTGFEFHPGSCAAKNSIRERLNAHFAPSLAEPRIPVAEALERACKLSVECIKTEELQALLERKDYVPISYDGFEPSGRMHIAQGICKAHKVNELKKMGIRSVMWIADWFAVLNDKLGGDMANIRLVGEYFKQVWRASGMDMSAVEFLWASEEINKNPDLYWRLVMDISRSFNITRFKRCSEALGRAEGDNRPAASLLYPAMQCADIFYIGADICQLGLDQRKINMLAREYCELKNVGARPIIMSHHMMPSLAHQGGKMSKSVPNSAIFMEDTEAEVNAKIKSAWCPEKEVTDNPCIAYFDLIVFPHFKTVTIPRKPKNGGDVTYDCQEKLEEDYKSGALHPADLKPALASYINRLLQPVRDYFQNNPEASKLAKQVAELQKLKAPAEEKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D826</accession>
    <name>A0A061D826_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Seroreactive antigen BMN1-9B, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0202360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767265.1">
        <property type="nucleotide sequence ID" value="XM_012911811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D826"/>
    <dbReference type="STRING" id="5866.A0A061D826"/>
    <dbReference type="GeneID" id="24563620"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202360"/>
    <dbReference type="OMA" id="CIRSWIK"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210:SF1">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="309"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="428"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="524" mass="57148" checksum="426DEFADF0F17ABF" modified="2014-09-03" version="1">MEPINAYARTQRLTICARMLMYRPETAELLDFEKNVVAEDTITLKPPSNDANDAATTDDAVPPQSSLHIVQNGQKIHAIADLEEVAEYLKTYPLALVLAKVVWRDKGCFICKPDVVSDHAHTGACYRIINSHVYRRAFGCKAANRRVAHALKEGDRIKLGRATLVVRHLARKPANSLSYIHEFMAQPTEEGRQPETSPEPADETSPEAADEIAPEAADETSPEAADVTSPEAADVTSPEPADEIAPDPANETAAPENAEERVQVEDIAVETVHRTISNVSTVMGPDSVINTQRSVTMPPVPRGACAAPEQDADQGMCRICLEGEESGSLVVPCKCNGSMKYVHLACVRTWIQGRLNVKDEHGQQQLAFFLKNLKCELCGVPYPSYIDVDSVWTEFLGIEEPSPPYAILEPENANHTGLHVASLSTASVSIGRNGSSDVVLPDISVSRCHAMMHYREGHFVIEDKGSKFGTLVQLADAYEIRVEAGTPIALKIGTDVLCIEAKIKRRFGELCCAGYSRRAVSVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D897</accession>
    <name>A0A061D897_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769097.1">
        <property type="nucleotide sequence ID" value="XM_012913643.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D897"/>
    <dbReference type="GeneID" id="24565452"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308150"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1663"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1736" mass="189027" checksum="8EF120ADF3A1C090" modified="2014-09-03" version="1">MSGHGVTLDTLKECFEFLEWLNGGQGQKNNVVNAFMTKLRPYYGSNSQFKKQLQNRYVNFVKNVASLHKKLSSQQVSRRGTYKVTPRDANQILDALLECTPKFLAALSFIQYHVDATFRDVGGGDWALQSPKSRDFQEFLTTGNNIIRGGFDAMELGNVKGGTLVEDLKTILNKYGARGNPVHDHFRNVILTTLGKSLDAVNTGNAVFLLPVFCELVIGDPDGNKYKSSVEKAIGTNTICWTDLKDHCQLLKEHIDQLTAAGFSATGIAFKPKEPVKFVTKAAEWCKANLSKAAGELGKMIPPSIRSTAELQSYAKDKLYPNGFIFDGSKPRVWAKSSNLNKWDPIFQKFVQLDETLRTLKEILEGTYNKSCTAPSSPKPQPSHVKVPEAPKEVVPEKKVPASPGTEAVKPVVTKAEAAKPTATKTEATKTEAAKPQAKNAGGSTDQNTSQSGAKPGTSSVGTPSSPHPGGTGAPGPPGTGTTKSSPPKDTVQKQQSPSPPQPALPPAVSPPGAPAAAGSPGKPGSGGGSTKGGGDAGQKAAASPAPKPQTPSDTSSRPQSSVVPAPDGVPSTGSGQGLPGAVQPGGNGRGKDTQGGGLKTQQPAGSPPTAHPQTPNVQSAGSPSPGVPAPGGGSGTSGTGSTSGATQQSGPTTSQNSTVATTTTSAGPGTGAGGGAGGGGSSNSQTQAQCPSHMRSERKGTETYCHPSVTLTRRPDFKVSNPDEVWNAIQSKTLPSYITTAANNHTTTQYKTVSTSVNHPNHTTQGSFQHPTDGRNRHAKPYYVPADGRPRKGVMGIRDVPSLDFDGESIPDKSLKRVQQEMRRNGELGKKRVAVKVRAKHDQALRDVQDRWNKDAEKIKTEDKEWRKRQEAGKLLKQSDDYAIVQQERKRAAAEALQKKLDDHRIAQEEELKKIQSAPSVDLDGSQPIYQYPYVINNHQDDFLSMYSVDGGVIPDPYKDQNDSERKRKSDDALHDILTEKQLQLALNLETEQKFKDARDVELQKFLHHVQDQSTAAEGLVSGKIVTPSQPESYKYQAFTVADGTPMVDKRHLQEDDIGKLQRKSAGDDWNDYVQRRKESLDKEEKRHRDEVAKKNSDAIEAIKSMGIPQVITEHAPRRPSPILYELPHFDIQVAKHTLPDDDLDFDLDFDDDSTHITNETPTDFVDPPFPAISFNIPPPGPEQPLPPPEDFSPDIISRPDLKMCIAPWMNQTKTGDSPDIPETELFPSQAPRTVRDMLTWLAGLRNPKHHDTLKQCIKRAFGGLHDDPSQLALSVNGSYVRPTDVFDILQLTAMFAGSVLTAIAPNWRASVATRTVQPKSSDEPDCCALLCQLRDYVYACCHQLQFLKSQCSRDKLSGGWQDCGYGSDITASKSPLQAFLTDGWDSDFDTHPFDPCNLCHKSRVRMGFQANDLPKSSQQGSAISSILTPSCGGDDPLLTLCSYLNCLTRRTPRTTGELVSFFHHFGIELHDFDQSKLSKLGTSLCNPHPDCPDWDRLKNSSLHAVKGIRGTEALISKHNSNHNNEHPRTLSTLVGCSSATANCPQHCSPITYRAYALYSQSFAHTYLSWTVYLPDSLRESLEKLHYDLKKHVSIKCSSLYLCSTALPLLYTHGITPPEMGLQSPLKCADVISKLKEIVNGGPIASLMTAMDNFLYNIREPFIFTLVALWSTALLVLANTMLYRLDVLHIRSHLIRTKASHHIDVKALLTKGRKMLSLYKDVDYFDEDPIGQLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M6</accession>
    <name>A0A061D8M6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0307820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769064.1">
        <property type="nucleotide sequence ID" value="XM_012913610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M6"/>
    <dbReference type="STRING" id="5866.A0A061D8M6"/>
    <dbReference type="GeneID" id="24565419"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307820"/>
    <dbReference type="OMA" id="CYIFYFR"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600697" evidence="2">
        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="29"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="211" mass="23265" checksum="D909F873FC1DE0D1" modified="2014-09-03" version="1">MQITVCRALLAAAAASCFGFKSAYAGYLDVATLITANKRLCLTEPIKKEMYTHIAVHAFDVRQEQGIAITIKEEGADKPIYEESNLIKHLSVSFTAIHGISVICCITAPHYDIYVGVSIKSGADARDYSIIAKSSHLDPVDAHLQNAIDEFSAFHKAQLTGSRSMDRTSKKAADAYYMLTKFAIANSVFVVISTICFILYFRSFFLSKKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U7</accession>
    <name>A0A061D8U7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0310390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769322.1">
        <property type="nucleotide sequence ID" value="XM_012913868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8U7"/>
    <dbReference type="GeneID" id="24565677"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310390"/>
    <dbReference type="OMA" id="GICNNES"/>
    <dbReference type="OrthoDB" id="364450at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="549" mass="61115" checksum="555A1C589ABB9B75" modified="2014-09-03" version="1">MAGHLTCSIKAFVAFLYAVYFVYLLTPLITRLAPFDSAGITQLIRSGLCTSSFTQDWAGSVWSCKDTRGARDGFVHVEDVSFFTNGGAAGATLVRTTKTKDGVTVDEIPSVTHAAYELLRICQKVERPLKRQSETQMHGLNLLKDVCPFLAAHIARNMPDKTLVSDTDDTWELVRVLLSTVGNVKGVAVTKFLSRLEVAHDKEHTSPKQRAGDQHIINIMRPVVTYLAENAEHRLPAEKITSSKLIKTQSPLSHVAQYAIPTFLAPALGGAKESVIRLFTTFPEAAAMFIFAIQRKLASYPRLAAATVEDRLVLLGIFIASLQVMTTTTFDSLDAFANIASKTGVDWTSRAPLDEFWDLVAKDKRSRALVFNMLRRAEALTVDPEFFGAMTYNVEIAARVTDHVLATYGLKANTPLERSSLIENVVYHMVQMCRFCVVDADNTGNLSLQEFIGTLMGEEDAKVFREHVSQVSDQQYNLFVRYNFDFINGRVKMAKLHNRKALEAINEKYNEVLDTFMVVDTDASGEVSLEEFIQHAYVTTPLTALDMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8X0</accession>
    <name>A0A061D8X0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768603.1">
        <property type="nucleotide sequence ID" value="XM_012913149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8X0"/>
    <dbReference type="GeneID" id="24564958"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303210"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="6984" checksum="8A4A1C63CB97F068" modified="2014-09-03" version="1">METGILKILEGKGYLLAIFVVCLCSMGLMCFCWYLYGELITEFYQTNVSEDFGKEERKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Y2</accession>
    <name>A0A061D8Y2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CWF19, CELL CYCLE CONTROL PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0309110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769194.1">
        <property type="nucleotide sequence ID" value="XM_012913740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Y2"/>
    <dbReference type="STRING" id="5866.A0A061D8Y2"/>
    <dbReference type="GeneID" id="24565549"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309110"/>
    <dbReference type="OMA" id="ISECEFC"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="227"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="323" mass="36889" checksum="9B1FD94E595142AD" modified="2014-09-03" version="1">MGYGAKRHRGNPRRDGPSDRPGHRGRGMAPYQFKVDEALYQANHEAAAALRRRILVREDAEGFDIGPCQFRQISKFKPLDLRDAPPRSHMGAAEGGCPLCASGVQREQRLSQSTAAFLAMEQQRHAILHDQLVLAPKQHMQSTLYLDDNAYTEIRNYQKTLVRMFDEQGKAVVFVELSLRDPYLRNKEDSGTRRHQHCRIDCFPIPAEALDEAKSFFRKAIGDLVPEWSRNKKVLEVKGKTGVREHIPRGFDFVHVDYSLSGDGIACVVEDASRVQMSFAREVIAGVLRMDAMARAFRKPDTYKQALSWLRNQYQNFDWTNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D908</accession>
    <name>A0A061D908_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATP-dependent metalloprotease FtsH family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0309360</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769219.1">
        <property type="nucleotide sequence ID" value="XM_012913765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D908"/>
    <dbReference type="STRING" id="5866.A0A061D908"/>
    <dbReference type="MEROPS" id="M41.A13"/>
    <dbReference type="GeneID" id="24565574"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309360"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="338"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR97033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="796" mass="86925" checksum="64064147252590DD" modified="2014-09-03" version="1">MALPALTPGCRALRRLFGANGYRLLRSGEPELAGGALTRLASQGRAFHSVICGAPPILNTTLRICVSGIRGSRHFSKKVPSGFGRFAGRGGSSDSKASGGEADSSTSSDPPKSEGKMGNSSGKPKGPGDSKNDGENPFVFLCAKPFRLLFYVLGALASYKVLSYNELPNEVTMQEFLSKYLMRGCVETILIVNGKSCRCILRSDSKTVPKVVSFRIRSVEAVERKLDDIQGLLGIHPENFVPVKHVEEVEWLQVLKYAVIVGIPVAYMAAIMWRFLHNSQYLDRVHRMRNLNLTDAKELKVGVRFKDVAGMHSAKLEISEFVDYLKNPKAYEQYGAKIPKGALLCGAPGTGKTLLAKAVAGEANVPFYFISGSDFVEIYVGVGPSRVRSLFKKARENAPSIVFIDEIDAVGKKRAGKGGFVSHDERDSTLNQILVEMDGFNASSGVLVLAGTNRHDILDPALVRPGRFDRIITINSPDLEERYEIFKVHLAPLKLNKLLDVDDLGRRLAALTPGFVGAQIANVANEAAIQAARRKSPDGVDLMDFEASIERIVAGLRRSNQLMSPEQKLVVAYHEVGHALVGWWLEHADPVLKVSIVPRSSGALGYSQQIADETPLFSREALLDKIAVILGGRASEEIFIGRITTGAADDLHKVTRMCYAFVSKWGMNPALGLVSYQRDGDDSAGFYREYSDSTALLIDNEVRSIIEGQYARVKELLKEKAELVHKLAKLLYDRETLSHKDIASCVGERAFPMHERLRPYVLGGISGAPVLPSLSGAEPEKPQGEVGRDLFSVACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D920</accession>
    <name>A0A061D920_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Adenylosuccinate synthetase</fullName>
            <shortName evidence="10">AMPSase</shortName>
            <shortName evidence="10">AdSS</shortName>
            <ecNumber evidence="10 11">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0105340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Parasitic protozoa lack the de novo purine biosynthesis pathway and rely exclusively on the salvage pathway for their purine nucleotide requirements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="10 11"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766411.1">
        <property type="nucleotide sequence ID" value="XM_012910957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D920"/>
    <dbReference type="STRING" id="5866.A0A061D920"/>
    <dbReference type="GeneID" id="24562766"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105340"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="20"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="21"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="304"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="422"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="434" mass="48560" checksum="7C90ABEDC14A14FD" modified="2014-09-03" version="1">MVTRTPFDPAVFLVAGMQWGDEGKGKAVAAFAKDVDIIAKYNGGHNAGHEIVLNGKQYKLHLLPSGSVYPYTTNVLGHGMVIHLSSLLKEIEMLRGNGIEVMDRLLISDRAHLLLDAHIEIDRNMEKARKAAGGEIGTTLRGIGPCHATRSSRTGVLMGSLLHWDFFKKSVMDIYKIHTDPETSEKMATEEIERHATLYKIFSRCICDTGYFISEAIRAGKRVLLEGANGSLLDINMGTYPFVTSSITLACGSYVGLGVPLSSPMFRIGILKCYQTRVGMGPFPTEFFDENYEHIQKDGTEIGVSTCRVRRCGWLDLVAARYIQRLNCFHAVYLTKLDVLTGLKEIKVCVDYRNKRTNDLLERGRFPATTAMLDEYEPVYKTFPSWESDISNVDTYDKLPENARTYVEFVEEELGAFIQWIGVGQDVKSTIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D949</accession>
    <name>A0A061D949_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768693.1">
        <property type="nucleotide sequence ID" value="XM_012913239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D949"/>
    <dbReference type="STRING" id="5866.A0A061D949"/>
    <dbReference type="GeneID" id="24565048"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304110"/>
    <dbReference type="OMA" id="HTDWFRE"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="1">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="173" mass="19401" checksum="747958C6EE835A5C" modified="2014-09-03" version="1">MEATPKGLVVYRKKELTDDGFYSVARKPSKKEVKAEGSKQKAADKPGVTKERKACGCAGSLHKCFSNCMGCGRILCVNEGEGSCFHCGTHVFCASELHKVPKEHAEDPEFQQAMELRKRLLTLDSGFSNEALKVHDLHTDWFREANSVYNENAAYALEQYYKEEAEKREEAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L2</accession>
    <name>A0A061D9L2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768858.1">
        <property type="nucleotide sequence ID" value="XM_012913404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L2"/>
    <dbReference type="STRING" id="5866.A0A061D9L2"/>
    <dbReference type="GeneID" id="24565213"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305760"/>
    <dbReference type="OrthoDB" id="366679at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="193" mass="22174" checksum="3D19D1677279A3B7" modified="2014-09-03" version="1">MDLRNCSPHCSPITYRAYALYSQSFAHTYLSWTVYLPDRLWESLQKLHYDLQKHRGSGKCSSLHLCSTALPLLYLHGFTPPEVGSQPTLTCQQVIGRLQEIVNGGPISSLMTAMDNLLYGIREPFILILVALWSLAFFQFMNPMLYRLDVLYIRSHLICSRASHLIDVKALLTDGRKMLSLYKDVDYFDYTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9V1</accession>
    <name>A0A061D9V1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767880.1">
        <property type="nucleotide sequence ID" value="XM_012912426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9V1"/>
    <dbReference type="GeneID" id="24564235"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208480"/>
    <dbReference type="OMA" id="NDAGWAF"/>
    <dbReference type="OrthoDB" id="372632at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="90" mass="9917" checksum="A2FF6B979DE54330" modified="2014-09-03" version="1">MAAGKAQEKYSRCTSQGRIDPNSRMFIMGIPTHVDTSSLRSEIENFGDVEVYMCENCPNDAGWAFVGFTTRDAVNRVCRVVKASPMHVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X5</accession>
    <name>A0A061D9X5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CSL zinc finger domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769702.1">
        <property type="nucleotide sequence ID" value="XM_012914248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X5"/>
    <dbReference type="STRING" id="5866.A0A061D9X5"/>
    <dbReference type="GeneID" id="24566057"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400120"/>
    <dbReference type="OMA" id="FNFPYLI"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="183" mass="20965" checksum="8F9F09E246A426D0" modified="2014-09-03" version="1">MLFTKTFLCNLDWDSVTRAFYRMYPSKYYPHVKEVHVIDHELVPEKRQLRVRRIARVKYDLPSIVHYIVGPSIEYFVLEDSVVDLGARCLSHRTFGLTMKDSYTYNETATIRATPNGQSEYSSSTDFGILAFGFLNSTLEAVSPPNRVLFISHLQVARRVVSDFSKTEAHHKALMQAAARLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Y2</accession>
    <name>A0A061D9Y2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768963.1">
        <property type="nucleotide sequence ID" value="XM_012913509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Y2"/>
    <dbReference type="STRING" id="5866.A0A061D9Y2"/>
    <dbReference type="GeneID" id="24565318"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306810"/>
    <dbReference type="OMA" id="EHPLFMD"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="367" mass="41589" checksum="795A9E85035527F4" modified="2014-09-03" version="1">MDDDDYHIDPEFLRKFSDQYGDVDHPLFWDEIPRDPAGNEDLEALQQLLADGETRESIAEKYKEVGNGYVQQGAYYYDAAISSYTKGIDAQGKNEKLNAQLYVNRALVHLKKSTAAAACVTVLAGDFVKCVDDCRNAIKRDPTNVKAYYRGAAAAYELELYKKALAFCIAYHDHVKEHGETGADDLPATLEAGSPDLLNVYKRTIDRLRERDEQIAAIKKREDKSKEEELTATRGVLKLLTANGIKLQPNLYEIPQSQNVVFYQDNGCLHTSCLLIYDELGVTDYIENFDYSTTVGDHLDVMFQDQHGEKAFKRHNSKCFYETARGDYHEFGTHETLATIIYVTKVAYRVAPVHVVHKDFDIKTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA00</accession>
    <name>A0A061DA00_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769727.1">
        <property type="nucleotide sequence ID" value="XM_012914273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA00"/>
    <dbReference type="GeneID" id="24566082"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400330"/>
    <dbReference type="OMA" id="CREINGD"/>
    <dbReference type="OrthoDB" id="365213at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596131" evidence="2">
        <location>
            <begin position="24"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="535" mass="59171" checksum="3BFD8F8F09CAB49D" modified="2014-09-03" version="1">MVRRECLITALVAVLGMLGNSHAFDMEAWANETPDTADIKNLGDKHMTDKAKDDYATALDITTENNSNSEVGDMDAVLKELQDQTLGGNIEGTQEATSGENVDNKKDVDVSETSKESEKSEQPRIEVPADDTDHAKIVSKEEYESNHKNAGLNEASVNITIPVDTSAAYSLIPTVPSDDSDATSGNNDAIIDVLEPSGQNMRLDTIAMIDETILKLDKRLRNFLDAVSAGAHDLDYYQRFLEHTYETFCREINGDLGQLDSVKSDADANGAPVNVQISAKMSSAIRESFDTKVEVLELAASEVAMQKSKEIGARTIHDALTNGLIAVKSTISSPGLTVHNEDAEMRNMNAIIARISKSLLAEIIKWTLNEERLKKKLFEEILKRNDFIKHNPTDNNGIDKLTQSIRDVAAKFHVAQNERTSSIQKQSGFKEYMDGMREDINTIQRLIDTYFATVHKGHAKALLQEANQELKKDSEAESGMRLRLAEGKMRNETNVNAEGTPEQLRCPGNYRPLHPDQPIADSNPCVRLDKWAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA01</accession>
    <name>A0A061DA01_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Radical SAM domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0312410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769524.1">
        <property type="nucleotide sequence ID" value="XM_012914070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA01"/>
    <dbReference type="STRING" id="5866.A0A061DA01"/>
    <dbReference type="GeneID" id="24565879"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312410"/>
    <dbReference type="OMA" id="GTIKWAM"/>
    <dbReference type="OrthoDB" id="538249at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="23S RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544:SF5">
        <property type="entry name" value="RADICAL SAM CORE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01062">
        <property type="entry name" value="methyltransferase_(Class_A)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="100"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="365" mass="41589" checksum="AD0BED8D21E198D1" modified="2014-09-03" version="1">MICSALERSARYAGICDVLRRSHAPRYRASQILRSVYQTKVPSYLDMLHIPRQLRENLHEHFDGSLLSLKACSTHKSDRACKILFEYRDGSKVEAVLLSFPTHKSLCISSQVGCAYACSFCATGRIGLKRNLSVDEITDQVLYFQQLGHEIDSISFMGMGEPLSNPNVFRAMRVLSDRQLFGTSSRRINISTVGILPGIKKLNRDHPKVNLAFSMHSPFTDQRNKLVPANNVYPFQEVFGLLDERIRLTGKRVWVSYVLMKGENDTVAHAEELVKLIKKRPEELQYLYHVNLIPYNTARSIGVYERTEETDIDKFKGVLKKSKISYSFRNHFGQSIDAACGQLFADYDPADQSQLFGHRRKVNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA08</accession>
    <name>A0A061DA08_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0400430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769737.1">
        <property type="nucleotide sequence ID" value="XM_012914283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA08"/>
    <dbReference type="STRING" id="5866.A0A061DA08"/>
    <dbReference type="GeneID" id="24566092"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400430"/>
    <dbReference type="OMA" id="RMCQFCY"/>
    <dbReference type="OrthoDB" id="360481at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="88"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="345"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="637" mass="71288" checksum="E01DB1FD6875740B" modified="2014-09-03" version="1">MARTALAGAIAALTSNTSNHVDRCLARCITPFPADVRIWGSSLVQLNPRPSPLLIRKILQAFTRRFKRVTLVANGRKVYANGIQLSSLRPQLAGGDLFIAAPQQSGKTLLYLLPEAIRRSYIKSGDVDKAAHKTLVLLPTVDLVLLGSRNAAGVLRQTCSVLALYYKDVLSGQHKSLIPRSDVIYTTPQCALKAMLATPALFEDVKTLVLDEAQRLLKAQSLSTVLRLKALLKPHIQTIVLAPRNDNILRERVSRALRVDMKVISFCPEHDGSPVTRHIWGPQRSAFFDVVMKSNANVNTPILPMPAIEQKAQEHKKRIVDHCRTKELFIDHRYRCEFVLYDPSKLCQMIHATLTKGAKAVFFYPTVRMAQFCYIYFKHCLKVKRPMYALHGGLSQEKRRYTIDVFSSVDDGVLFCTDIASLGLNLGDVDFVAHVGAPESVEVLADRVGMVKTKEYECSNLLLLHDLDAHVLYEASQLNCDIQPTKCSPDQSTKFDVPRSWVDNPCYSASCELMYRSLLGYYCNHAMRLKFERWQVPSLVCEIVRSFGCTDTFSVSHQFASRLQLWDAPGLVIDRQSKRKTELQAAAAGYPGFKSRAIQTNTTQVDELYRTPLPIMDVANSRDSLIDAPTATACQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA40</accession>
    <name>A0A061DA40_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0109130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766801.1">
        <property type="nucleotide sequence ID" value="XM_012911347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA40"/>
    <dbReference type="STRING" id="5866.A0A061DA40"/>
    <dbReference type="GeneID" id="24563156"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109130"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="325"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="513"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="953" mass="106900" checksum="C0E7AC096A6F6464" modified="2014-09-03" version="1">MSGGAGRDDRDEPVGAPGTSPVPNGGSNGSSEPLDGASGNSGLRDDELEVLRRAEIAFEATKGRNIDMRHDKDYMERMRIEARRQYLVNREVDRLELAERALGEKEILYKGVKDDTARKTLEFEKSTVEFAKTTIASRAADISGYVMPDSYDEDTSQRLEVLKRKQTYKQMDAVVDDGQSWETQQMKLGGISRGSASRGHTSASMPGTGQMQPPTGIPGLIGLDGTIDFVTSECHSGELPTEFDAKAVGVNAVAAVFEDAQESSEEESPSDSDGETSDSTAATKKRKTFADRVLAKQRRRQRQEHRKLMEERCRLPIYSYRHELLSAIRNHPILVVVGDTGSGKTTQIPQYLYEVGYGKAGKIGCTQPRRVAAMAVASRVSQEVGCKLGQEVGYTIRFEDCTSSNTVIKYMTDGMLLREMMTEPDLASYSVVMIDEAHERTVHTDVIFGLVKDLCRYRNDFRLIVASATLEAEKFALYFDHAPIFRIPGRRYPVQIYYTKAPEANFLDASVITVLQIHVTQPLGDILVFLPGQQEIEEVQEELQNRLRNRGKDMRELIVLPVYATLPSDMQAKIFEPTPPNARKAILATNIAETSITLNEIVYVIDCGFCKLNSFSPKTGMESLVTVPCSKASANQRSGRAGRVRPGHCFRLYTKFSYEKEMDDVNDPEIQRTNLAHVVLSLKALGIDDLINFDFMDPPAPETLIKALELIYALGALNDKGELTRMGRRMAELPMDPTYSKMLLSAEKYKCTHELITICAMLGVGNNIFYRPKDKQLHADNARKNFFRTGGDHLVLLNVYNQWEEAEFSVAWCYENYVQHKSLRRARDIREQLVELMKRVEVEVISNVTDTDAILMSVTSGLFTQAAVRGGPKGSGAYRTLKHPQNVDIHPQSALFDQEPKCVVYTDLVMTTRQYMRQVSQIRPEWLTQLAPHYYTNDNPALQGSKKMPKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAN7</accession>
    <name>A0A061DAN7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769799.1">
        <property type="nucleotide sequence ID" value="XM_012914345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAN7"/>
    <dbReference type="GeneID" id="24566154"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401050"/>
    <dbReference type="OrthoDB" id="365697at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="249" mass="28747" checksum="2F0476D77FAB3491" modified="2014-09-03" version="1">MEPVNKKWSSSCLELISVRLDHLDAKYTSVLQRYEQNHKNIEAKVGQIQAAVLSLEASMADNDRLSHVYNNLNGQFDAKIAEFRVDAQNWLDGMIVTLDMYARQQLDHISFDANLMQEKRGLIKLDEMVERLKTLHSNIINDMKDVVENRLSCERKLIETITEGKFYSQHGIYHQKRKGSSRLGAIMKTLNKEEIRVEMAKLLSNFKNEIISDITEMSHSREEFEDFVLETLEGQMSDFISNKTTAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB37</accession>
    <name>A0A061DB37_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769939.1">
        <property type="nucleotide sequence ID" value="XM_012914485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB37"/>
    <dbReference type="GeneID" id="24566294"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402410"/>
    <dbReference type="OMA" id="EIRPNEL"/>
    <dbReference type="OrthoDB" id="365588at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595972" evidence="1">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="135" mass="14666" checksum="AFFDD5328AAC444C" modified="2014-09-03" version="1">MAATWQIFVALCCVLRCFSCDAAEPKKGLNIDVSFGGDVPLGQITGDDSSGALLEVTRPVPYIEIRPNELESVNRLAEIALETEAISPVVHKEYYQVLEQLEELSPEEMLSELIAQTNTLEALKAELGAEESVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB48</accession>
    <name>A0A061DB48_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768325.1">
        <property type="nucleotide sequence ID" value="XM_012912871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB48"/>
    <dbReference type="GeneID" id="24564680"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300440"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="28999" checksum="D9FD326BDB8F93C4" modified="2014-09-03" version="1">MVHHSLTEVPRSFKEAVDWLMALRDIDGEKSLRAIGDAVYKFLANKPVGKMEVPALEEVKRISQQFLEEPELKENSYVKELLNRYKTPMNKTDNMWWKSFRAFNGSNYSNFIKTGGLNAEKIARNVDHVTYGCAFLLDNIKRHDQYKSAYTPEATWETSCTKDPEACAVILVGIAPMLYVGLNALWDAMNGVIWHSNDNTRERLVDVLKALGYVEPECQIRNTPYVFRGLRHVDRDMLEKLYDLSGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB55</accession>
    <name>A0A061DB55_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769954.1">
        <property type="nucleotide sequence ID" value="XM_012914500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB55"/>
    <dbReference type="GeneID" id="24566309"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402560"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="77" mass="8480" checksum="B050E3EB20A44C87" modified="2014-09-03" version="1">MASSVHPQFVNHAIYLFMPHLAFGPRRHIIQSYVFDTGCVTRSPGHPGTFTNNIVDGMIYEGMGIDGYPALDSKAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB71</accession>
    <name>A0A061DB71_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chaperone J-domain superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768345.1">
        <property type="nucleotide sequence ID" value="XM_012912891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB71"/>
    <dbReference type="GeneID" id="24564700"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300640"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="139" mass="15933" checksum="BF50B57A3D907F2D" modified="2014-09-03" version="1">MGPDALRELARAARVLKLDTTKKIERDDVRCSFLQAVRESHPDKGAGSVNEFNEVMSAYNKLNRYFDERDEQAAYREQHQSSFGQPVYDHDMVFSEQENAYFFQCRCGELVEVSTIAIALGVKSYTCETCSLLYTPQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB82</accession>
    <name>A0A061DB82_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768355.1">
        <property type="nucleotide sequence ID" value="XM_012912901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB82"/>
    <dbReference type="STRING" id="5866.A0A061DB82"/>
    <dbReference type="GeneID" id="24564710"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300740"/>
    <dbReference type="OMA" id="SHREYKP"/>
    <dbReference type="OrthoDB" id="10598547at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="266" mass="29980" checksum="19F0C1AF4B733C8A" modified="2014-09-03" version="1">MHSIRNGPGAALAEGDTLGLAFPGSDMAYAYTGTGGLSVSTSHREYKPTSVKGRRIPHCYVYSTLQDSVFKFSTVDLPSFVQPSIYFCWMVFSPQMGVKLHELLSELDPQNESLSYICVWKVGHTVAPESAVIEINDQPFVMTSSEINRIGVDIEMTEPSRNCDRHDTLDDSMHFVFPTLNNTAYMQQLIGNMAQRMKPTRKVLTKHIFSSTPTLEAFTRSLLTRQFDLSDSVLLLRPDAHIHDFWPTTQDIDIKIKSYLNQFNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB95</accession>
    <name>A0A061DB95_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-binding protein 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0404530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770152.1">
        <property type="nucleotide sequence ID" value="XM_012914698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB95"/>
    <dbReference type="STRING" id="5866.A0A061DB95"/>
    <dbReference type="GeneID" id="24566507"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404530"/>
    <dbReference type="OMA" id="DEHITIC"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="338" mass="36696" checksum="B47C158EF31BD887" modified="2014-09-03" version="1">METKGAWVLRQAALTVAIVVGYHLLYRYFTKRESNPDEPASGTQRDAAGGEVPDDCPGVDTPEAGTKSACQGCPNQAKCASGELKNENEKMIASVAANLGEVKKVVLVMSGKGGVGKSTVSTQLSYMLSARGHHVGLLDIDLTGPSVPGMTSTESAEVFESARGWTPVYVSDRLSVISIGHMLRNTRESIIWRGPKKDSLIKQFLIGVDWGRLDYLVVDCPPGSSDEHITICNLLKGVDTLAVLVTTPQQRCVDDVYRSAAFCEKAGIRIAALVQNMTQSVFDITKPEVVGELCQRFGIRNVLCIPLRPDIVTAGEEGRPMEDFTCIDHLEKFIHDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF0</accession>
    <name>A0A061DBF0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EXPORTIN 7-RELATED / RAN BINDING domain containing PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0202270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767256.1">
        <property type="nucleotide sequence ID" value="XM_012911802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF0"/>
    <dbReference type="STRING" id="5866.A0A061DBF0"/>
    <dbReference type="GeneID" id="24563611"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202270"/>
    <dbReference type="OMA" id="DCFHELC"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057947">
        <property type="entry name" value="TPR_XPO7/RBP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25795">
        <property type="entry name" value="TPR_XPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1104" mass="124688" checksum="505BB11D7FB4A4B6" modified="2014-09-03" version="1">MDPKDLEQLELLCQALYGGQPLQQNEAHEVLMPLLRDVQKIPLLRDILAQSANLQALLFAASGLVTVITNHWSHVSDAHKTELREFLLNYLYNRGPEMLKCAPEVLGQFIHLYCRIVKLGWLEEVSNHPVVQHVGQFLSASTQHWIIGLSIYSDLTQEMQPQMGKFVAKLRRGALNFKETVLPKIFSVTVQTLEQFNNGTAVVADSFEETRMLQQILQLCYNCLSFDFMATMPDDTSEEQSTVMIPQSWDILRSDKVPRTLFELYAKNSVVRPSCAVLCLRCLVVVAALRKSFFNTEAEDLCHINSFMMGTMDIIRNKTGLANEDCYHELCRLLGKINASNQLSQLLQSAVFPMWTEQLHNFTMEALANWQHMPNSKHYLLGVWAHMVVPLGYMRGKAPSVLETNILQITLEFIKSRLAMAEVVATAGDDLEFDNPLDDDILRMEQSDLFSRLCRCQYRTVCSRIIESFQELEKMPMTHNYMAIKQEKVAWLVMLAGAMLNGSSSLRLTGDESNITAVCLQTMNIELVGHVFLNMDASDSKLTECTKLEMSFLHFLTYFKKFFISEHTKGSISGDCRERFAQVPGCPPGTDGAQYLLNRLVDKVFFNLQRRVSNEGVIKKTLNFFSELSSGIDIVHYADRSPHLVVSARLILQCKTLRFALVNHADPGFMFLQVPQYGRYRTIYYSILCKLLLLELGSEEEQGDSVPKFEGFMEHHRLVIDQLWNLNAGVLSSPECRSTIIGLMRDLRGVCRSCISVEAYQMFFNWIVNAPKQPGKSRLHIMKRIVEACWSDCDVMVPLVKCLAEFLDNRGHRITFDKTSANGILLFKESAGIVMSYGVKLLQMAQAAGGVRQAGNDREAYKKIYKGAAACLQVLDHTLGGDYVNFGVFEVYGDATLDEVLQLAFQLCLVIPIEDLQAYSKAMHPVYSFLDISTKLFMPQMLSLSLENVVQLINACMDGLCSYESATSLSAASALDNFVTHVYNERNSTLTGGAPHPARVFLESKLECLHRAMVLIFNLLLSGDSNSAWSVSRPLLGLILLNQNEFTQLPRSLSVNMSEEKQAKLQRCFESLMNGLDTTLSHQNKDTFTKNVYIFSQEARLSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBK0</accession>
    <name>A0A061DBK0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Aconitate hydratase</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="3 9">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0404160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3 9"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770114.1">
        <property type="nucleotide sequence ID" value="XM_012914660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBK0"/>
    <dbReference type="STRING" id="5866.A0A061DBK0"/>
    <dbReference type="GeneID" id="24566469"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404160"/>
    <dbReference type="OMA" id="KWPETFG"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072350">
        <property type="term" value="P:tricarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01586">
        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="90"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="713"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="910" mass="98950" checksum="6EE762228DEC84D3" modified="2014-09-03" version="1">MYATLSGALRSDSFGVSRYVRRLSTMGVNPFESLRKRLGVTPKQYFALRELNDPRLLELPYSIRILLESAVRNCDEYSTTKAHVESILGWSETSTKQTEIPFVPARVLLQDFTGVPTIVDLAAMREFVASTGKDPKSINPLVPVDLVIDHSVQVDFSRDSAALKLNQETEMNRNSERFRFLKWGAQTFENTLIIPPGSGIVHQVNLEFLARSIFDRDGLLYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEATMLGQPISMVLPQVVGFELVGKPAPDVFSTDIVLAITSVLRSGAGVVGKFVEFVGEGVQHLSLADRATIANMAPEYGATMGFFPIDGLTLEYLTQTGRPAEKVELLDMYARENMLHAGVGDSSRIKYSSVVRLDLSTLRPSIAGPKRPQDNILVASVKEKFGDLLTAKDGKGYGVEGGSRASEFSFKGRNYTLDHGSVVIASITSCTNTSNPSVMLAAGMLAKNAVEHGLEVAPYIKTSLSPGSKTVTRYLELSGLIESFEKLGFYNAGYGCMTCIGNSGELDPEVAECISENGLVVCSVLSGNRNFEGRVHPHTRANFLASPPLVIAYALAGRMNIDLVNEPLGVSCKTGQPVFFRDLLPSKSEIASFEQRFLKPELFKEVYANITHGSDAWRALEAPRAELYPWDPSSTYIHHPPYFQNMDAPRESSITDARVLLLLGDSITTDHISPAGNIARTSAAAQFLLSRGVEAKDFNSYGSRRGNDEVMVRGTFANIRLSNLLCPNQGPKTVHHPSGEVMSVFDASERYRAEGTSLVVVAGKEYGTGSSRDWAAKGPALLGVRAIIAESFERIHRTNLVGCGILPLQFLPGESASSLGITGREKFTIADIDRVTPGCLVRVSCDSGLAFDVRCRIDTALEQQYFAHGGILQYVLRRICGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBQ7</accession>
    <name>A0A061DBQ7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pumilio-family RNA binding repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0203420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767371.1">
        <property type="nucleotide sequence ID" value="XM_012911917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBQ7"/>
    <dbReference type="STRING" id="5866.A0A061DBQ7"/>
    <dbReference type="GeneID" id="24563726"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203420"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="294"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="319"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="427"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="499"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="572"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="645"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="799" mass="88366" checksum="C392CABC408E107C" modified="2014-09-03" version="1">MANTLSSGGLKEAYFGSSQQKAESEDNAVDNGFLDLPLGRHGQTFPSSDDTVLTFDNLNGLESDLTLTHADYLGAFHTFEALTRERYEDKVTHPHDDLHVFEHYDQCDSYSTRYSEAAYDAELKNNSAMMLKFDTLTESVLKQLETPVLEPKTDVFTDVNLCRLADMDPKLLESLCNAGINIREIVSPKPANGSSGYGGCGEGNYDSGARPAQKQTSMPHLDIGSNDVERAYSQEDNTSDHKANFGLNYKLCRTARRRGKRSEDCEQPVLTRGQSEISAIKYFAANAHKAPANKCKSMLKPMHATVAPAWVKNSILGDKVSNNISAIAKDQAGCRMLQKLLESEDQALINSVLEGVCKNLFELMTDPFGNYLCQKLMSVCCENNLTKIIDSAGKSLVDVALNMHGTRALQKLIEVLRTPEHIRKVTHVLSAGVVQLVTDLNGNHVIQKCLSSLTAEDCEFIYQAVIKNCVCLATHRHGCCVMQRCIDAANERQRKQLVEVITTNVLRLVEDAYGNYVIQYTLKLKDNDINMRIVNALAPKATLFAQQKFSSNVVERCLIICPPDLRSILIERFIKAPFDVLKELILHPFGNYVIQRVLNVAQPDELGALLNRIKPHIDELKNASSGKRIAAKITRKHYNEVNAAHKEAHRTDQQKLDFSKGAKSNAHASGRNNRDIAGDLLRKVQRSTVYRGASPNNMSDNGTLFQQQSFNNMKSNLADGLSSMRISRGTNFNASEEHYQGKAVRASSMGADNGNSGMGPVSLEMLNSLFSRTLTIGSDPASLSEYFNPGFPDGTPHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU2</accession>
    <name>A0A061DBU2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0302480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768530.1">
        <property type="nucleotide sequence ID" value="XM_012913076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBU2"/>
    <dbReference type="STRING" id="5866.A0A061DBU2"/>
    <dbReference type="GeneID" id="24564885"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302480"/>
    <dbReference type="OMA" id="NIPRYCE"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="213"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="384" mass="43648" checksum="87C43A48D575ED00" modified="2014-09-03" version="1">MSLVNIPRYCEDPNYRYKMPRLQSRIEGRGNGIKTNISNMGEIARALKRPPTYATKFFGCELGAMSKFEESEEKALINGAHTERALTQILDKFIEMYVLCAECHLPEIEVLVKKGVLCSRCNACGHKGSLDNTHKAATYMLKNPACLTEMSKHSSRTKKDSPKEGSADKEKDKDKEKEKKKKEKKEKEKKKRVSEDGQEDVNGVDGGVHGEEMEKLTVESAEICDIVDRLYSSLETGKFADPADFAEEVHMLQLSQDFDNVCRFYVAFCALFKDKFDVAALEQKMVLLKSLVKYAVQPKDILTAMAAFVVKMHPQQLEEYPYICRALYAGDLAEGRDFCRFYSKSARFEGFLAEAYLRTKEKAEPFVTWLQEDEDENEDSGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU4</accession>
    <name>A0A061DBU4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate/Leucine/Phenylalanine/Valine dehydrogenase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0313440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769628.1">
        <property type="nucleotide sequence ID" value="XM_012914174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBU4"/>
    <dbReference type="STRING" id="5866.A0A061DBU4"/>
    <dbReference type="GeneID" id="24565983"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313440"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="657"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118923" checksum="F009BE540374B9A2" modified="2014-09-03" version="1">MTIDDTLDNYLHDDGLSRVPESDERNDAPLSDRYANQFKEVYEIVKQLKTFSDDMINQTMDQYYNRLGLNEYYFSTSNSKMIANNMVSVLTAKILHENSGSDYFPLIEQVHDGRVFIITRASLLNQKIYQSYAVERSVEKRYLNFGDMTKPIWRMQCFRSTNSIFDDPDNLFERLRIYFLQLPNFAVTDPEPGELRLSKLLDRDFYKNKKNTITEDIFCKLNKQLVESDTGLGIAISAEPRQFNTYRIDVAFKREHIQSDFYSRVGDCITYYGCYSKSKYIDPLSNNVCIITAFITTLPSTEIANPDMTLEDRAHAIVTAIRLCGVMPHTHYLSILNERLLDVAEMAYAFCASIFIEHFSGSVGPHISLIERLMTREQITPSELYDIRSKLMIPPYLPHQIFDAVRANEGILKMLYQNFRKLHDPALNPSGTNDDPETPRLREMIKTLDDQEHAKILSFFLTFNACTLRTNFFMQEKLSLSFRFDPSFLSKNDYPQSPYGIVMILGPYFRGFHIRFSEISRGGIRVVQSFSQEAFTRNKLQVFDEAYNLSYTQSLKNKDIPEGGSKGVILLDKAASKEMAAVYTRSSFMCYVDGLIDVMMPNEQMVDRLKKEEIYFLGPDEHTGTGRLMDWAANHARLRGFQFWRSFTTGKEPGMGGIPHDVFGMTTASIEAYIHELLDKCNVKEEDVTRFLTGGPDGDLGSNALLCSKTKTLAIVDRSGVLYDPEGLDVNELRRLASLRLKGENTCCMLYNSDLLSKRGFKVAEEAVDIVLPDGRNVKRGYKFRDEFHLGGCSCDLFNPCGGRPSSITPFNVNSLFDEKGKCIYKFVVEGANVFITQDARRILESKGVILFKDASTNKGGVTSSSFEVLAALVLDDVTFDETMTVKKGGECPEFRKNYINEILDIIKRNARMEFHALWNEGLRTGKPRCDLTDILSSKIIRLKKDIMDANSLWADLTLVKSVLARAIPLSLQKLLSIEEIMKRLPERYMRSMFASHLASTFYYVQDFTDDTSVFAFYEYINMLRGGENLDVSQTFIMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC65</accession>
    <name>A0A061DC65_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0205180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767546.1">
        <property type="nucleotide sequence ID" value="XM_012912092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC65"/>
    <dbReference type="STRING" id="5866.A0A061DC65"/>
    <dbReference type="GeneID" id="24563901"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205180"/>
    <dbReference type="OMA" id="MKDIILH"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600258" description="indole-3-glycerol-phosphate synthase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="10">
        <location>
            <begin position="68"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="569" mass="65348" checksum="B295AE1F41CC0BBC" modified="2014-09-03" version="1">MSITYRLIVIAQSLLIHAYCHGSSRFSTCRSHLYGYGFTSSPKSRFNGSLRAAGDESLRYKAEERFYKIIADKHAQVERLLDDHKDPNDPLQLRLKFVECTANHKLGEMLRRHSTEQGHGLSVIADMKRRTPTQHHTLDNSVLSFLDASDVAKSMASQIYFNVQHWFDVIFVNTDETVYGGHISELHACFLELRKLGRRIRPAIVMKDIVIHPIQIAQAAEYRADGVLLNASVLGNTLKEMIIACLNMGIEPIVEIHTKEEAMLALEFGANNLLVNQWDRVHNFLRPTRALEIKNIIGDEATLIAAGGIINFAQVHELALMGYDAVVLGRRLSYDDTPEFVERIRQWQAPCKSILRLSKDMFFDIHDEGVARTIKLKRNHEKLLNEMNVFYGRKGVDVSNIMKANQESDALPKEPTHQQSFVNNQYCNDGDDIGDTIVTVTYGNPAQTTFVRNILSTVECPESRIDTNKYLTERKSEMYRMKWYVERQRWVRRFRHHFQNRRDANNAHRLKKAIEMYTAFLLYGAQLLKSKKSNVCVEEIGQILRQNVKAAYEEAPRDNLGNIIMPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA3</accession>
    <name>A0A061DCA3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767616.1">
        <property type="nucleotide sequence ID" value="XM_012912162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCA3"/>
    <dbReference type="GeneID" id="24563971"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205880"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="322" mass="36286" checksum="20D0B2811FD88AE7" modified="2014-09-03" version="1">MVYTSLTDAPHNFKEAADWLLALKGDDVKNLKAIGEAVYKFLVDKPVGRINLPALEKVKRISKHFLEQRELRNYWFVEELLKRYNDLISKSPGAWAKYFRVVDESDYKNVVKSKGITAEDIAKNLDRIVNGTEILRDSIKIPDEYQSAYSSEATWESSCAKDPEACATVFVGIAPMLYAGVRSLHTASIAATLNLAPLTRHEYGLRKTMKALGYVEPECRTNMSGLDVGRALRGLYLRRVLTLCDLAGFWAFYGSKNAAVKSGELDKDAQEFIDFYVNMKPINPPKKYVLRKPPSTYTATGSNNMYYPWLPTVLDMGDTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCB2</accession>
    <name>A0A061DCB2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">-Ganglioside-induced differentiation-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769883.1">
        <property type="nucleotide sequence ID" value="XM_012914429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCB2"/>
    <dbReference type="STRING" id="5866.A0A061DCB2"/>
    <dbReference type="GeneID" id="24566238"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401890"/>
    <dbReference type="OMA" id="IHPTFWT"/>
    <dbReference type="OrthoDB" id="365077at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF72">
        <property type="entry name" value="GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="68"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="511" mass="57381" checksum="05287B38EA23EF35" modified="2014-09-03" version="1">MTEHAVADLADTVCWVLGEIEHMIDPDLPPLTTPEPPRYIDKVPQCHMDAWKDFRKWVIAEVPTCDAQPKFRVNEELNEKIFIGNCDILQLEVGATAVFVDEFMPHASRTARRIQTQYGNDIPYEELGRLRCGDVMLRRSYNIGSEHVVYAVSPRYSAKYPDASANILNMCVRETLKAAIAAGVDSVAFPLAMGREVTYPDREFATAVLRAVRRWLEVPKVATNIARVFFFGVDEEAYRLMQRFFPRDQTEEKLSAEISDAGNEFGEIVKEERNIRISAGLRGDSVESDGTAAKTMHINAPLANFSGNCRVGSDRQLSAKDYDFDYYCRLSLSLMRTPVYREMDTSKFALLLGRDVAQRPVIAIDAARMPSSISNTHAVAYVLRIMQPILQNKFAMLLLNMDSSLIAAGSVCSVASQLFQVLGDVRLGNLGVVYVHRAGWATRGMLYVMMVLLPDAVRDSVTYVDTAESPSQPATVIYITECITKTSETKRHIATQELKKYIELPNNNKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCB5</accession>
    <name>A0A061DCB5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769888.1">
        <property type="nucleotide sequence ID" value="XM_012914434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCB5"/>
    <dbReference type="STRING" id="5866.A0A061DCB5"/>
    <dbReference type="GeneID" id="24566243"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401940"/>
    <dbReference type="OMA" id="YMDSIVK"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38187" checksum="96181780B3DDF67B" modified="2014-09-03" version="1">MASLNNEVPAPAPAVGSAASAGKTISASVSKPLVAAAAASAAASSLSQLVKDADEGGRCTLLPGLFGLSIQLFLCIISIAVVFLKYRMETPRRSLPAFLMDFITLMCGSGTVHVVNILSSIMIQRLHDGSGEVGDECNLYFMTTLFDATIGIFLEYKIVRYLAIRKEAHHYLQRTRKSVFTPTTEELDDATRIATVALSSGSPIGMNETDLEGHMPGRDECDNVFETFEFGVEGGWRRRLWRHLVRLVTSPNEWARDMGNEKFVDNLLSWMAIVCSLKVFSIAVFTIFSGSINSIGDFILGFFEKRHTLKLLFVMVGAPLVLNVFQYCVTDTIIKIKTVGRSHTAMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC6</accession>
    <name>A0A061DCC6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter, major facilitator family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0305370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768820.1">
        <property type="nucleotide sequence ID" value="XM_012913366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC6"/>
    <dbReference type="STRING" id="5866.A0A061DCC6"/>
    <dbReference type="GeneID" id="24565175"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305370"/>
    <dbReference type="OMA" id="VAGWMSY"/>
    <dbReference type="OrthoDB" id="331466at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF9">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="583" mass="63769" checksum="ED708D2210EEB1E1" modified="2014-09-03" version="1">MSDENPAGPPEHHSDNDETKASAVVEMQSIEPGNANDEIQGDKSKVEGLVNRRICYIFALMAVLECFVNYDLGAMSVMVPLIQSQYAFSTTDLGIMGALPFLGLIVLSPIIGTVFTFFKARTIIALGLVMNVSSLLVFALAYNKVMFYLSRFLVGATQSFFVIYAPVWVGCFAPDARKNLWMAILQGSIVGGFMLGYAFTAILKDASDDGWRISIGSQMGVLSVLVYLFMWTPSQYINLPSMETPKKEADETPVEADSEGSVVVMSNMAALRSRAERSPSSPRSIDDSTVLHNRGYSCEPVTKRPSILPGDTLQMLPSRNSCIGRINTDIMKRPSIISATCHLPCRSNESMVSGAPQDPENGESYTLWSSCKIILSNPYFCFSTMTVSALFYVVTAIQYWTTKVAIALYEVPESLLYTLFVATSTTAPVMGVIAGSWIIDVLSARYPSKPIIIDLVLVSWTLVTLLCALSVTLWHSFYNLVGCIWVILFFGGGLLPPITLITINTISEPLRPMASSICMCLYHIFGYIGGTLLPGVIMDLTETDRSAIFATYFPVILGTLGAMGNALARYYEYKRAPAAESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ3</accession>
    <name>A0A061DCJ3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6 7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0402950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6 7"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769993.1">
        <property type="nucleotide sequence ID" value="XM_012914539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ3"/>
    <dbReference type="STRING" id="5866.A0A061DCJ3"/>
    <dbReference type="GeneID" id="24566348"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402950"/>
    <dbReference type="OMA" id="HADPEHS"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595694" description="Long-chain-fatty-acid--CoA ligase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="682" mass="75751" checksum="6A6E8971751C90C2" modified="2014-09-03" version="1">MEAHKGFSNLGALLGFYGLAIAGTEEEGFSPIYRNTASETLKRASDHGKFQTMWDVFQHGLKINPDAPCIGKREVKSDGSLGAYRFMTYKEVESKALVIGSALHQLPIEVQPSCHPKVKDSKMVGVFVTNCIEWLILEQSCNAYGFTLVPIYNTLGNESIHTILRNSGISVLLCTPATAKTMLTVLELGTEGVNLELIILIECDAVDDALKNNSFGIKFMLWSELEAMGKKKPLPPSPPHPDTLALISYTSGTSGTPKGVMLTQQNVTDLIVVTCEDHVKKSFIENPMERHMSYLPMAHLFEKNFVNAVYYFGGCIGLYSGDIKKLLDDVQEFKPTFFVGVPRLFQRIHDKVMAGVAQKSFVVRGLFKAGLAAKMNRINTTGNYSHALWDKLIFNKLKLLLGGQVKWMLVGSSGMNPSVIERLRAIFGVPLLWGYALTESCAGSTAQNFHDTDPTSCGGPLPSQEFRLRSVPDLQYDATAHPPRGELLIRGYNVMHGYYRDEKATQEALVDGWLHTGDVVEILPSGAIRIIDRVKNVFKLAQGEYVSPGMVESVINMGTLVAQSFVFGKNDEVYTVAVVVPDEDVLKHWKEANGMGSLSFKEVCGRKELRDAIMAEMEKLFQENNLKGYEKVKAIYVEHELFSVENDLLTVTAKLRRHKLRERYAAEIDALYKELRAANKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCK0</accession>
    <name>A0A061DCK0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770008.1">
        <property type="nucleotide sequence ID" value="XM_012914554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCK0"/>
    <dbReference type="GeneID" id="24566363"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403100"/>
    <dbReference type="OMA" id="FIFIMRD"/>
    <dbReference type="OrthoDB" id="328439at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041316">
        <property type="entry name" value="ISP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18161">
        <property type="entry name" value="ISP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISP1 C-terminal" evidence="1">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="158" mass="18330" checksum="EAAF50BD68FFF319" modified="2014-09-03" version="1">MPAIFSFRRILGIFDSCCAFEDCRQDANEFEIEEQHFRDRLRSSVNVMVLLEVGTRRNGCMCWQDGSKLSCTLHVNCDQEIIRIACEDQIREMKFDAIKKLLHTREELGRVQTEGPCLNFSTSVALHLSENGNCIPLTFNNIQEKRLFLNILRPFIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCP8</accession>
    <name>A0A061DCP8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L2 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0404150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770113.1">
        <property type="nucleotide sequence ID" value="XM_012914659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCP8"/>
    <dbReference type="STRING" id="5866.A0A061DCP8"/>
    <dbReference type="GeneID" id="24566468"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404150"/>
    <dbReference type="OMA" id="GGRHPCT"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="258" mass="28234" checksum="6346D9203A25C4DE" modified="2014-09-03" version="1">MGRIIRGQRKGRGSVFKSHVHLRKGAARLRRFDYAENHGYIRGVVKDIIHDPGRGAPMVKIDFRNAYKYGTDHEHMVAVEGMYTGQYVYFGREARLSIGNCLPVGKMPEGTIISSLEEKRGDRGRLAKASGTYATVIGHSDDGKMTRVRLPSGARKSVESASRAIVGLVAGGGRIDKPLLKAGTAYFKFKAKRNCWPRVRGVTMNPVDHPHGGGNHQHIGKPSTVSRGAPPGQKVGLIAARRTGLLRGGKKKKFRNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCS5</accession>
    <name>A0A061DCS5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0208940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767926.1">
        <property type="nucleotide sequence ID" value="XM_012912472.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCS5"/>
    <dbReference type="GeneID" id="24564281"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208940"/>
    <dbReference type="OrthoDB" id="365890at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1744"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1818" mass="197312" checksum="D1B17185F2360EA9" modified="2014-09-03" version="1">MAYNAFKFDTLSEIFQFLAWLKRRGGKHNTIANMLVPRFLPFLDVSKRNLQFAMQRSLNNLIEKMTTLHEALLSTEIAKLGDTYAKLTQQEILHVILDCIPKLYAALSFLLYNVSDNYKSVGGGSWANQNATSTGSDLCKYLTSTNVKDYNGIIPGGFNVIELKNQNGKALVRPLTEAVTREGGVRTGRGKDKQGPPNHFTNVLATTLDRPWQDVNTGNALLLMRAFQDIVVAEGDGSKGGLAKEDWDKDIHPKRVCWADLYKHFSGSQTPFKNVFNDGGFGFTGQVYNITKKKEFAEMFSKWFKTNYQHIKKNLQKMSEKTDDSDVHLFATTKLYPYGLIFKYDGKTHWENTLKTHWSNALSMFNDRGHELERLKNILEGLEKVKCLESSGPVATKTKATKTEAAKPVVTKTEISKPTATRTNAGRSKSPHKTSNRDLDQSARGKGTQNQNKKAEKSSNQIKSSTEHKSPDQAVVKTAATQLPNNDGTRGPTGPKSQGPQGSTAENKPHDPGAQESIGSVAVKVEALTKSGEVSHPTLPKPSPPASSTKNAGSPKTPVEKNVEKGPTGPAENTGKAGANGKADQDLSTKNPDQPPKQVAQVPPVLTPPASPPITAAAPAPNAPSSDPGQDSQRGGAPSQEPVKPPLSAPPQSPSAAGSEIVSHGVDSSGSGQIPDKQAAPGAAESSPSNKFGRTGGTDPASSAPGAGSISDEAGGEGGGPPGTQGASSRGPSDDQSSGGDEVSKTLMGGKTSESQSEAQSPPTTPSSGSSSPKSKAIPTPTDQGKGDADVPTPGDTASPSRDPKASGSGGDPQEQDPNSSDGAASSPSNGLSQPQPAGSHDIKKAQDPLASSPGGVSSSVPSPVGGSGNCDGLPKDTNQRDSASSAHVTPISGQSSVDQAPDSSAQTPKMQSPQPYPVSTPAITGDSQTDNAVDSGSSTSEPSVLPPDPNGSGTKRSDTDDDDAKGATSPSHSHDKTCVHGRSPVNFGGVTLCQHTRTAIARTVHGHKTPNTLWDEYEKEEEKRRLNQPFSSKNVIPSLYSNPGRHGNPTNYSNTYRFRYYTHKSSVGGHQIYPPPDDIPLHTAYRNYVPIIGYEGPDMLNPEDPDEEWQRKQTTLQRKEFRDKNDKILSELKMQVLTYSPPELPKIGIAVGNRLNPPRLQKKVPPSPPSPKLLGKPGSDTIPESTLVTDEEAFPSNAHVDLVIEKPNTEGDEDTTVMRPTAPLQKVQVKPARPITQLPSEAPSSFDAGEEIQDDLEEEEEQDAPNYRHDVVETIDVCRDPWHISPSSTYPDQPTQSPPPSADNLPTPNTVRGILYWLVGLVALEYVGIIHRHVEGMLRDFDKAIGIPAMPQHTLNISLSELPLVASAVTRILTEACYYAASVLCRLKHIDISNAIKDFDFAAEYSQLHYAADPAALLCQLRDYVYAAHHQLAFLRLQCYRDEAQGGWKDFEYGSNVGVSSSTLQAFLTDGWDSKFNTHLFDAQDVCYQSRIRMGFSDADLPKETKQGSLLSSILSPKCDPYDPLMTLASYLVCLTTRTPRTTAELISFFHHLGNALYEFDPDILSDVGSSLIDHPVDYFFWAHIEEADLLSIREIRGCDPLIQCHDHHNTLSNLIGCDIYPIPCPQQLLPITYPTYALYSPTFVPTYLSWMVYLPDRLQDALDRLRRDLKYHTCYGIKPLHMCSDAVSTLYFHGFAPPYDALKRPPNCSDVTAKLSSVLSGGPISKLLTCMDDFLYRGRKPFVTLVFTLWSIAIVCLIHTQLYRLDVFRIGSHLIRSKASHFIDVKALLTPSRKMLSLYDADYFDDADIAQHYPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD77</accession>
    <name>A0A061DD77_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768211.1">
        <property type="nucleotide sequence ID" value="XM_012912757.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DD77"/>
    <dbReference type="GeneID" id="24564566"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211670"/>
    <dbReference type="OMA" id="NSEYWAG"/>
    <dbReference type="OrthoDB" id="360323at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1293" mass="145196" checksum="3FEE40F36C454183" modified="2014-09-03" version="1">MAIVANACRDSGREEAVSIVTEVLSPLLETVDSLSVVRAPATNGIAATGLIQPILHYIVTDIVRDPWKTEYLGLFKTACLDEDNLVDVLQYGLATRLIPEVRNYERAHGALHANEAHVKRICQVLEAISLTVGGVPPALMSELGGDILIPNLKFLIGERQGTSRLTQSQALICHVLIRVATAAMISSQHAFEELCFGYHIFDLMIVPVKETMAEPLVLAAALNTLAVLTGNPMKGQTFSAAFMEEFDAGVLLAYLRPLRMQKMADVYKEHAKTCMTAIGNFIAHLLELSRRLPMMCQLVDVMYGKGLAVLILDALSHKEANGDVRRALVRALVRFPIERIDSGAVAIMLDLLSPANFREFEPQVFEYIVDALKHKLDIYSVERIVERTCWLLLVTLKTPEAERYKVLHVKCVELLLAASNRPTGKVLFREERHSLSLRKALKYEEDFCAYDHPEVRVELACVGGDVAFLNACMFDTFRLKHDSKQIFRVFRTVNRAISDARGRPENELLTIEDICACEVGDFDDEPLEPRIPHADESRPDEHSAEETPDSSIANPESPPNNAVAVPINVVGGDPVEQDRLFPHDEAWQIDSNVHRDQQRQLYVSMDMPKKIMSYLSASFSASFTEYYQMERKRKAHSEYWAGILKGRKLDCERLNIVDKFDWSVECSEIFCGENLAETSQLCEGISNAISKPTRQLVSYVNWKQWRSHQGTMRDGAEPFYTVRPRKHLNKVWMNECKKVLNPCFVVSSFLRTLHALMAPSVSVVVRDAVRGHFRQADFVRNLIKLTTCSSFLDANLTAKLLRVCERAFTIDASVQAESMDMIVIYDIVSRFAASFCEPLMVITTNVSVDWVDDSMHHVQLVLLRVFRVFALFARQMPWIKFSNVLEIQQHFVEKCVIRCVPEHALTLALRILFQIVSLETGSSVGTYVSHLYESSLLEQIREACVDIAVAASCAARNTHYPHVLNAISELRHSSSLLLRRSIVSDILRRIRLADLGKRFQEKVSETRLERVLLMDDAWIVKKGGSTQNALMAVTSRRLHVLRAKREDEFRTQAKFRPSAAIWEIEGGLLYVVFARELVADTTAKLTDPQWAMFTLRHTPPKAFRHYVTAGNIPTLGRLAARALGDATTYLGLCLWDGRICLAALTKDKLAIFAVDHVLLAEGIRSGTFTCEEYTTDNGDMRAGQPLTPGHKPKPNSGSHGTESDDESSESESEGSPREPIELLDECYCDSITSVAYGADLAVAISVTDPDDEDEENLWELTFVSDSRREAFKKALAGSIGHLTWYRRWESDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD88</accession>
    <name>A0A061DD88_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768241.1">
        <property type="nucleotide sequence ID" value="XM_012912787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD88"/>
    <dbReference type="GeneID" id="24564596"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211970"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="64" mass="7172" checksum="283354E0157FCDDD" modified="2014-09-03" version="1">MGDRLMRIGSTKFKDYITLSLIRFLLLAKDRPPDNERQNISRQEISVDLFIDADGGNVASCSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA1</accession>
    <name>A0A061DDA1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0311220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769405.1">
        <property type="nucleotide sequence ID" value="XM_012913951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDA1"/>
    <dbReference type="STRING" id="5866.A0A061DDA1"/>
    <dbReference type="GeneID" id="24565760"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311220"/>
    <dbReference type="OMA" id="DVYWEST"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595720" evidence="5">
        <location>
            <begin position="18"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="659" mass="74429" checksum="6C4EAEEA6F9E978E" modified="2014-09-03" version="1">MDAAALVLAALWSVSIAACRRLTFIGSRTLRNSLGTYNNVTWARVMPVQASRLDTPDTETPCDDDSSKNAPPLDDPDDLSEQLGYQYTEEDLQRERDEIRDFYEINTFSMKRDKLPRAHPLYKFLREERKKAIKLERIHKWRQAEGRRQEWRDFFNSVKCQNGTCENIFTEEQQDVWKRLMDKTMQIAEPLLEEVEAILSNNKLSLEKRNELAVEVRKQIKDVQEQVFKEFEPEMLACGALQKTQEYFANVPTYVMDVCQPDINHNVYIKPENCTLPADIVWSNTVLGSGREPNEPFWKFHLLPSLGQKKKKRLGRGHGSGHGGSSTRGCKGQKHRSGRYINPVFEGGQMPLYRRLPKFVGRPVGPGHRHSRREYQLIPIHQLNVAREGMVVDWATLECLGARLGRYKRGHPIKVIGGKKYAGVAKPLTVRNLIVKAHAFTRSAAREIMDLGGRCMLLRPKTVDIVEEEYHPDVPRARRYIFSGKISRRERRRREIKQRIWEEMQKSASSGTAPTETSDTTDQPPLATPETIASSTAENSISPADGATLPPDESPSPVSDMPPGEEAHSPPGESDQLQTESPEIAEEHDDKHCDAISPQSHTDAPVTQSNTTISAPAEAEENPGISRPDEDPTTADDGGEPPPKRRRGRKPKSLSADNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB2</accession>
    <name>A0A061DDB2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768306.1">
        <property type="nucleotide sequence ID" value="XM_012912852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDB2"/>
    <dbReference type="GeneID" id="24564661"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300250"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7709" checksum="CF3BF520C51EB24A" modified="2014-09-03" version="1">MQRSPGSPSLPLVEQQTGQRSPSNPIPYIIVPVALVIIVIIVICVMIYFCIRPFHRSNDCIDYQSHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI5</accession>
    <name>A0A061DDI5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769630.1">
        <property type="nucleotide sequence ID" value="XM_012914176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI5"/>
    <dbReference type="GeneID" id="24565985"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313460"/>
    <dbReference type="OMA" id="APCRDYR"/>
    <dbReference type="OrthoDB" id="360042at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="371" mass="40118" checksum="03203EB241BA83C8" modified="2014-09-03" version="1">MAAFNKANGIYSAKLGLYMYALALQMALGYCMLLCSPNKLNISAIVASRQLSDIRDIGFDVLQGAGAVHVVLAVLTFGFLILTHFVTICFKIPMLVLTVVQTAYCSATASICAVYLQKGNSFINKTFQIFAKTVVGVVDPKLNDLLVENRNFLFLIGLLSVIAASLFHKAQMVKGTDSATQVMVVVPSISLGLGIAFALCAPCCGYRTFSLGLLWSLTCIVGDVISSVSRFFCFKPLKIIMLAVHALIVLLSVVTIGVCTTIYTGGKIDYSGYLAILHGEVQKLGDTGHALANYQNVTSYLQKITDSYSDETLNLLMGNGVYFIVIVVLSIVCLLFGILSLLYSVFRFFDRSRDSVESDAANTQGMKIVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ7</accession>
    <name>A0A061DDJ7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0302090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768491.1">
        <property type="nucleotide sequence ID" value="XM_012913037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDJ7"/>
    <dbReference type="GeneID" id="24564846"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302090"/>
    <dbReference type="OMA" id="KNINCCT"/>
    <dbReference type="OrthoDB" id="364848at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="345" mass="39287" checksum="6F032FCDC427D6F1" modified="2014-09-03" version="1">MGDFKELHAIVMGKDAPQFQTDAECQHISSYIWELFFKDYNEISTDLRALHAEDQNARARLHRLVDQSTRSSLNKIRAVYGSGAELTCITKPVEEVQRLSSITDSYTTGISNNCDEYSANVEECDISNGNSELLNSMEDLYSEILQEDGEQRVPLLIAYEELLHDVSKVRDSKMLQILKSRVVRMKQEIQDELYKAFNNNVNTTLKIVSEIRMLGISNDNEIAAGFIKNRSEYVSECLKTVQSLAKESIHRAIHEITLTLKTKLLSIIVCYTAIFGSMDANVTSLMRTTIFQFLHLMKQELHDARASQLMPKHVADIQQEMREISHSFEGFGLSFTPLLQEIFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDQ2</accession>
    <name>A0A061DDQ2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="15">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0400960</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="15"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769790.1">
        <property type="nucleotide sequence ID" value="XM_012914336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDQ2"/>
    <dbReference type="STRING" id="5866.A0A061DDQ2"/>
    <dbReference type="GeneID" id="24566145"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400960"/>
    <dbReference type="OMA" id="PTGIWRM"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="4 15" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="16">
        <location>
            <begin position="38"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="17">
        <location>
            <begin position="501"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="428"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="14">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR97604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="636" mass="69127" checksum="AEFC676D51D57540" modified="2014-09-03" version="1">MFKGAAIFRRLAPHSRRFSAESITKRVAGHSVVEHSYDAVVVGAGGAGLRAALELSSNGYKTACISKLFPTRSHTVAAQGGINAALGNMTEDDWRWHAYDTVKGSDWLGDQDAIHYMCKQAPQAVIELENYGLPFSRTESGKIYQRAFGGQSLKFGKGGQAYRCAAAADRTGHAMLHTLYGQSLAKNCQFFIEYFLLDLLYENGAVVGCVCMRMANGEIHVFKSNNVVMATGGFGRCYFSCTSAHMCTGDGNAAVARAGLPLQDMEFVQFHPTGIYPAGCLITEGCRGEGGILRNSEGEPFMSRYAPVAKDLASRDVVSRAMTCEILEGRGCGPNKDHIYLDLTHLGEDVFRDKLPGITETAKIFAGVDARKQYIPVLPTVHYNMGGIPTNWKAQAIDRSDNTVPGLYAAGEAACASVHGANRLGANSLLDIVVFGKRAALSVIEACTPGEQSKASPVCVRGAVESTIAKITKLFASGKCSGPSHTQPAAKKDGIPTSAIRLHMQKSMQDNVAVFRDGERLKRGVALLEECCDQFKDVKITDTSPAFNTDLYETLELENLLTLAMQTVVSAEARKESRGAHSREDYPARDDVNWRKHTLSYIESPEFKNVKLAYRSVIDTTLGSDMETIPPFERTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDQ8</accession>
    <name>A0A061DDQ8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0303840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768666.1">
        <property type="nucleotide sequence ID" value="XM_012913212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDQ8"/>
    <dbReference type="STRING" id="5866.A0A061DDQ8"/>
    <dbReference type="GeneID" id="24565021"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303840"/>
    <dbReference type="OMA" id="LICNERN"/>
    <dbReference type="OrthoDB" id="365044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17748">
        <property type="entry name" value="BRCT_DNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="278"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="855"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="888"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="909" mass="99229" checksum="77961CEA9BE9FA3D" modified="2014-09-03" version="1">MDIRSFFGGIKKAAPAAPEEPERPSERAFTGELKTTIRRSIDESAVSHGVKQGDTNSVVASVKREGDEDDEVAIGGRRKRLKRLVDSDDDSDGLLDQPGVTAAQPQKESGATVRTYLKDEQGGAAFSPAEGIGKTSDVQLDIDCYTTSGKNLVNLSEKVTKARKPSIDLDSYLCSVGVGDPAGKASPISMFTSPVRSERAKQSPKRELSKTADVKSEITTQTALTKPVPEKVERTLSASHGAADLFGDDEVLPSSANSSAATSPVRSGKRNATLDARIPEGEVDGMRFVFTGVLEAIDRDSVLQLVRKLGGIPVTGVSGKTNYLVCGEKLEDGRHYKTGTKYKKAVELNKQQRADIRILNEAQFLELIDYDKVCNSMAESMKSEATKQNMPSAPLTKAGAESGHKLPFCEKYRPSRLSDLAGNENNIRKVVEWLQSWSPGSGPACALLSGPPGVGKTTTAKLVAAECGYECVEFNASDLRNKSAVEKISMLATGGQSFSFTGQCEMKRTLVLLDEVDGMGAGDRGGLQAVAALLPRSRCPMICICNDRHNQKMTTLGNKSLDVRFSSPTLAQFRNRMKLICDAEGVTVPADTVAQLYEQGGGDFRHALNAIEFNTLHEAGGSQRSSNVGDAKDIGHTKNLFDAAGRLFNVRATEFETRVRDMEQYFFIDYNMMPLMIQENYLKYLPPHRGSLPILQKLSRTFVEADIVEEFLKRVMLSSVLPAMAIVSSGGTCRERLMFPQFLGRFSTTTKNRNFLSEIGKHLGPRSLVRSHPLVTEGYLNIIYTRIMKELATGDIDATAALIESYGLNRDLVVDALCSLRLKSQENLYEKVETRKKTALTKRLNELSVKVAPMKRKKETVDRIVDEDEAEPPVESDAESSASEGKLVKKNQKPAKKRATAKAAPRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU9</accession>
    <name>A0A061DDU9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769895.1">
        <property type="nucleotide sequence ID" value="XM_012914441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDU9"/>
    <dbReference type="GeneID" id="24566250"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7664" checksum="45680800CB3C2EE7" modified="2014-09-03" version="1">MLQIFAALFNHANTLKFRRYVAQNVLQTLGVPCYPVVNTAATGRTQTLLTLSAAINEMLCNFKRLRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDW6</accession>
    <name>A0A061DDW6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769935.1">
        <property type="nucleotide sequence ID" value="XM_012914481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDW6"/>
    <dbReference type="GeneID" id="24566290"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402370"/>
    <dbReference type="OMA" id="LFFDRSW"/>
    <dbReference type="OrthoDB" id="443651at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="27441" checksum="F5E6BA1CB68EB4FB" modified="2014-09-03" version="1">MMKSISSDDFSLTRNGDYVAWFDNEMPLSKLPFWSTLLASCFGCVIGTICSLIVNCALVEVSTSPFFTLYFAFTFIVIGIVILWRLNISTAEVDGKQRQFLRYFGLMSWFTHFPFVLKVAIYTLLGISISFALTFTIVDLVNYFISMFETSVARPLVESKSQVLVILVIACTMGAVFGFMFGFMKVEDEAEYHIKLALAKEESYTWPVGAVLGTLAGFCNNYLRHQEFWRFNRDNAYNVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDY2</accession>
    <name>A0A061DDY2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769970.1">
        <property type="nucleotide sequence ID" value="XM_012914516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDY2"/>
    <dbReference type="GeneID" id="24566325"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402720"/>
    <dbReference type="OMA" id="PLDLRYM"/>
    <dbReference type="OrthoDB" id="365625at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600828" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1209" mass="136601" checksum="AC5C9D22FE9AEA90" modified="2014-09-03" version="1">MRFVTLVALLGVVLSSTAFLPCDAFLWFFGRNKGSGKVSMFFHAIPYIFRKSGCVPWVNKATNDDILSNKYIYIDLFSRKHHDAIEATPQDDDTVNKRTNILLYQVNTDLLPHTYNNPTLGDVMYYSQLLQEYGEYDRRTILTYKDDLKRLCVLIESFDGFGERVSMRLYRARRKVWWLKQVASEGNVLSDTWATVMSSLGWTTPKPVVKQTLNIKESNCPIGMVNHKASTYDLIYNRSPSAGTESIGDVIFRTMPMTLMPGSTDLYVWRFFESGKHENIKYVVIAEVFPTHSTHTYYKCLSVAESQYEVVDSFAAVTDSPEKLETALPLPNYTKELVELSYNFGNTRDHPFESELVVLAYPETKHYLIRPLSRENLKVIMKLAVHGSHNGFDLGIAEADGYTYLAFTEIDKKFQRRISLASVNGTKFGLISARVSLEKSVPPDMPLCDQHTFSLLRHALPVQYLSLPHNERISMAKFVDLDIMDYNEADVLAGQVGHGMILYTPSLGACLGFKNLVIGKEQSMTLKASMNTQVLVAENGKKTVIALVQDGVKEMQLYETNGNSATLVDANKKFKLLKEYNLAEFDRITKDGVTPVQSMITLNLNDPMVNGDVELFMVSNNVVVYTPQNAESRILVFVWGREQLMFEETSNPIFTVITGSAQKYLLVDDFVAQGNRIDRYLYAMEENILYNKLRLLSKVQCSTASSVNDLRNALQNTWYSIIPEKLPVLADFHDGRIGNAAFTYHNMSTLFLNHDHEFSVGVLKIGQTSAETEAGHRWRQVFRNAEGEGNVYNIYTMVPKGIKHDRINTNNKMTTDAIVTFRRRLYPALNKDAVPLMLENLNFSDVKSVTSKIGNIKVTVVKPSDTSKVFNPLVFGHHEIQFVSAYKCVKVTISQQPDGLREISADLSHSDGGSSMINFREKNPGSGFFRFVRDDEESNAAEGRFVDVNEMFADYARHFDNLDVVDFNNGIFPHYVRYLTLSENKVYFTGNVMHTGLRVVFGTHTVIVDQSSGRFHLWVTYPGQKSETATLHVHYTAEEKPVSAFYTVENSNDAKMLRRPREYNCNWGPLSNLEFVTVNHILTRHTQLRSELATVNLDLAVGAKSPVIIKMTRDPSTTVYTTLASSGCVIDHIMYKGAIIRGVPKQIVKHVYHSVGPKDEIVLIVVRTIAGVMAQAYKFTGRGSFETVDMSRVDATDHSSIHFVMNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE11</accession>
    <name>A0A061DE11_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0306540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768936.1">
        <property type="nucleotide sequence ID" value="XM_012913482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE11"/>
    <dbReference type="STRING" id="5866.A0A061DE11"/>
    <dbReference type="GeneID" id="24565291"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306540"/>
    <dbReference type="OMA" id="EWAEEEW"/>
    <dbReference type="OrthoDB" id="364016at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="22375" checksum="A51425D29908DEC9" modified="2014-09-03" version="1">MVAEYKSAGSSCVVCSQDVSAASSAAGPFTGEVTAGLLKDMDIEWTIIGHSERRGGGPLGIDERRELINRKLKAALAAGLKVIVCIGESGGRDTNYVIQQLEASHKAVTLNNSQDICTGITDSDDRLVIAYEPGGCVGTDRPAAPEEVNETITSIKSMAKCNVTRSRFIYGGSVDRSNASLYTRQPNVDGIMVGRLWQHPEFEPLLETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE42</accession>
    <name>A0A061DE42_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNF2 family N-terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0307040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768986.1">
        <property type="nucleotide sequence ID" value="XM_012913532.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DE42"/>
    <dbReference type="GeneID" id="24565341"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307040"/>
    <dbReference type="OMA" id="VCKPEEH"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="337"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="936"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="911"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1402"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1548"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1680"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1798"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="912"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1402"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1548"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1680"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1706"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1803"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1845"/>
            <end position="1855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1855" mass="209330" checksum="62DB1723E2E68BF3" modified="2014-09-03" version="1">MAPRRSWCKLCQDDYKTGDAIIKCTSCPKSYHRECLEHDIATGGAHNAEVVNGQYDFSTFQCENCLRYEDENVIENDERCKLCKEKNRDDRDVLLLCDGCPNSYHISCLQLVAEPDGDQWFCPMCKPEDFQVVTFRRKQNPLAESGDHVNSSICYVCQRHGKLLGCDFCSNSFHHGCLPEFDVGTIGDVWECPCCKGQDPFINQMHKRWTVQQIDKNLKERRRCIQLWKAKITKYRNRFLLAHRDELGPFVTDKCMEVLTRNLMDEGSSARRRLINCGRSIDDILEYFEEEGMIEAEKFIAKAHKSSFYPSGRRIDGRPLRTGVQLKPHQEFGVDWLLKSFLTGGAILSDEMGLGKTIQTLCFLSYLKMMKIEGPHLIVVPLSTVGNWLREVHRFTPHLTSIKICGSRTERLHAMEDRLAYKGLYDLYITTYETVKSEEEFFVETIPRWQCLILDEAHRIKNQSGAARHSMDRILANMRLLLTGTPLQNNALELFTLINFMFPDIFKDTVMMDEALRNQPKRFGRSLPMSQAASAAAAANASFKKEELEAIKTLLSRVMLRRLKEEAITLQPKVFHDVWLPLSSESLRWYRTLMSVRYLMKEQMSVKKLLGMVIKMRIVCGHPRGIVSRFHQTEKLFDFFKQESLPIQNQVEADAGRLRELRDKEHRDASAKLTFLDKLLCQLHYENCEFVPGYQDQYNAHLKELETIKEHKLKLHKKMKGVASQEPFVIESHEFLVRNPAPTARNPRFMVDGMYESPVSTESPYKRETLNLSLSGKKQAAAGGNNAKTEQNANAAHKRGRILEEDDVMMNGTGPAADGGQGSAEVVDGTHVKSEDGPITNGVAPGAWDVKSENMETNVKNGADYLVKQENADDIRMSENEVRVKEEAAGVVLKREGSDAKVKKTSGKKVKSANAATKGANMAADADPAASQSEVSKDPMMHKVLVFTQFQLVLDELETYCNCRGWKYMRLDGSTNKLIRELDIREFNSPSSPYFIYLISTRAGGLGINLTAANHVILFDEDWNPFIDLQAIDRAHRIGQKRSVHIWKLISEWTVEERMALCREKKLHLDKMLINSNRQAMDYEEAAEAPIVSLTPAAILKMMMHGNNALKLTDCEDITEWYLDDIIARGRKTPPEGLDDSVEIDETEDVSLLQEEVDPNMVNVSDVMKEEDAAESDNASMSCEVAEEVPTILEGADLRVSDMLDHKQVKKLLSTAKDKAELLRKLESGGLLWRSGRERRRPSSMYVPEGFRKRAETRSIRHECRCFCCGYAKNHKAHYKDKDGVTVELDYGPLVQCFRCPKSYHKVCESLVEPKKTWTCRWHECCLCFRKSSQCDNMLIHCSNCPTAFCYDCFPPDYTRHYVGEDYYYALTQRGLNANASNWIFFLCSKCKILQEKDRRKKMTKEEREQQQKQQRELRKQLASSDVVDDKESRKRRREDRIVFLDNFRSLETQYENRIRTAYERLCPPNLIEEVTKRIEAARAKRDSDEAAGIIRLKREVNFLSVRLPYRILQLCDNCKLPLHNSVRYPTECPFPKEIVKLEVTVPSEGQTGLSQTSDDGTVTGGESQSGAPGKVVKKTACAKCLLAFTGKLSHTRRSCDLLTEEEMQDYEDRRKRVTAAVEMLESLGAEGPNEIDYAAIPHARLKAIYTTALEDMDKIVLDCFSKCGVELVPALSSSTLASAVSPPSPGVAPVGNKSAAGGTGSESSFGQSNASIPNSPRLKQSLPQPSAESAKKRVASGGAEFPARMSSPSTTSLEGYVGSPTVISNRSSHSIPPLSLGGLSPADSLNIAIPKVKHASSHDATTAPPTSSSADSSRAPSGDPALSIMATTHIPKKSSPQSDGDIREYFAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE83</accession>
    <name>A0A061DE83_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0405430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770245.1">
        <property type="nucleotide sequence ID" value="XM_012914791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE83"/>
    <dbReference type="STRING" id="5866.A0A061DE83"/>
    <dbReference type="GeneID" id="24566600"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405430"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR98059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="162" mass="18554" checksum="2FCED9C2D08CC746" modified="2014-09-03" version="1">MTTIARKRLAQERADWRRDHPIGFSAKYSPLPDGSGLDIMNWICKIPGKKGTIWEGGEYTLTMEFTDDYPSKPPKCKFTPVLFHPNVYPSGTVCLSILNEDKDWKPSITIKQILLGIQDLLDNPNPLSPAQADPYMLFVNNREEYNARVRKQALENRPNDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEB7</accession>
    <name>A0A061DEB7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0309130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769196.1">
        <property type="nucleotide sequence ID" value="XM_012913742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEB7"/>
    <dbReference type="STRING" id="5866.A0A061DEB7"/>
    <dbReference type="GeneID" id="24565551"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309130"/>
    <dbReference type="OMA" id="GHTMAVQ"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="480"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="524"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="742"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="775" mass="85021" checksum="3DBF6912F586E20D" modified="2014-09-03" version="1">MDSLTSYDSDDGAPPGDTAPTTLTPAPSAGKGKQGSSATNSAYKGINNGQQPGGDGLITSNPVHQHFLAFGSGRSTPQSSVTQSSDPSSTTNRNPYTPSSQTVNHGSTAAQAPSASESTKSQPTPSFANVNTMDTEALEGAGSLSSRIHASYHRSNLAKSNDISTERPVRYGGKYKPSTEESSSLAVLPDGRMGVVSVQFGSRNNATGLVSVSGADADAGAAITEPEVVARKMQSMEANATALMKSRLREHTRNAQDMVLLNYPVDHPYHQSISVITQKALESYNKANRNPMAPEAESVSGVFVTPSGVTEKTYVDEVSFDDQLREGDRQVSLAHQSDGDAKRRRRLTEKEVEEEGVFGPWRPYEETVQPAADVAPKEEGKPEEEKPKLPVFETNTHKMAHVGMAFPSCTPDVALGRNEIVVEDGKSETRYDGVVVSTFHRTVDPSSPPSRPWVLPPKNLKMVDPEEYKSFLPKKEVYTYTGHTMAVQAIRYIPRTGHCLLSASMDGFVKIWDANNNRRCMRTFKGHCKGVRDIAFANAYGTKFYSCGYDSSVILWDTEYGKVLGVYAQEALPYCVTVYPKDEGIFIVGGANRKACQYDARTGKVSLEYSAHMSNVSTATFFNDDRKLMTTGDDRRIVIWEYNLPVPVKQLADPSMHSMPAVVMHPSDKFMLAQAMSNQILVYESSHSRFRFFGGKRFKGHICSGYAIRPTCSPDGRYVASGDVRGRVFLWDWRTCRNLVTLPGHKSVTMDCQWHPLQPSRLATCSWDGTIKLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DED8</accession>
    <name>A0A061DED8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tetratricopeptide repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0310080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769291.1">
        <property type="nucleotide sequence ID" value="XM_012913837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DED8"/>
    <dbReference type="STRING" id="5866.A0A061DED8"/>
    <dbReference type="GeneID" id="24565646"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310080"/>
    <dbReference type="OMA" id="HIKVWIS"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="61"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="669" mass="79964" checksum="51387D0F6492ACC4" modified="2014-09-03" version="1">MAPFDPSKLQVKNKMPAAVQITAEQILRDAVEWQSRENRVPNRTFVDQDELVYYKAQRRKEFEDTLRRQRHHIGTWIKYALWEANQQDFRRARSVFERALQVDANNANLWLRYIETEMKNKNVNAARNLFDRVVCLLPRVDQFWFKYAHFEELLGNYAGARTVFERWMEWNPDERGWMLYIKFEERCGEIDRCRQIFERFLEHRPTCSAFLKFVKFEQRQKNYPRARAAFVKCLEIVPPELLTEEFFIKFAAFETSQANIAGAEKVYEQGLMTLPRENAELLYRTYVSFQKQHKDKETIDNLIVTKKRNEYEQHLLDEPYNYDVWFDYIRMEEQTLSDDGHPEGIDQAYAEAQRTRICELYERAISNLPQVDNRRLWRRYSYLWIGYAIFSELTLGQPDRAIAVYRKALQVLPKEFAKFYILLAELHLRQEDLDSMRKTFGMGLGRCSKPKLFEAYAQIELKLGNLDRCRHIHAKYIEMWPFKPDSWLAFVNLELMLDERERVRALCESAIAMDQMDMPEVVWDRYIEIEKEWQQHPYVRNIYERLILKTTHIKVFKGYAGFEFESGYLDKGRAVIERGLEFYKASGHQVERAGLLAHLLQMERHYGDSESVAKAKSRQPKKVRRKRKLEDGSTVEDVVYVFPDDGLQQSKILQAAMRWKQQQQQMKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEI6</accession>
    <name>A0A061DEI6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769531.1">
        <property type="nucleotide sequence ID" value="XM_012914077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEI6"/>
    <dbReference type="GeneID" id="24565886"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312480"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="177" mass="19659" checksum="BDDB7FBDEFB9FE2C" modified="2014-09-03" version="1">MGITIRYGARCNECDYVCKTYQECNCCRWCCKKCKTSSGCYLCYDGFFYRNSGNKDCHPKGCKSQTQQCPDFNTCGCTCCLAKRPRAEVAAVTLSSPGAESQTRALSGTSSQNDFIDDLHEQDSTPSPPPYSAIAAIIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DER2</accession>
    <name>A0A061DER2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769911.1">
        <property type="nucleotide sequence ID" value="XM_012914457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DER2"/>
    <dbReference type="GeneID" id="24566266"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402150"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="81" mass="8997" checksum="24BACB5C28EEE658" modified="2014-09-03" version="1">MTEEAWQAYGQSNTPVSKEKLLISGEAPTTVYKRGSCDVLWPKSLKRSQTVRHFDAASCQPAYLPPTVQSIMPHGNNFLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEX8</accession>
    <name>A0A061DEX8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770241.1">
        <property type="nucleotide sequence ID" value="XM_012914787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566596"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405390"/>
    <dbReference type="OMA" id="WSFYRES"/>
    <dbReference type="OrthoDB" id="364130at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1630" mass="184358" checksum="B22F3A33DD913D89" modified="2014-09-03" version="1">MASCEPQPWLHEFRRCLKSLKNPEEYVSFALSYNPHEQLLRDPPVSAQGHDRRKRLESTTRKCRDGSMCSGIVTPSVTDVYNCGTSAFVRSRDVQLDLSKVYLLLSNAKDVSAKGYPSGYSGARLHNAVVSSTRSDSGESDDDGFNSSNIGDDHGKQTSLLDHVVRRFERYVVICMALAEQFPFEHASYQHSPDVDLAGSDKREKRLLRRSLTNFRINPGDYRNLRGVSDPVKEVETVTADLNVVTTLSWPFYRDATCDDIFKLLCYSLMRGNFQAFDIILQNSEPCILEHVKESWSVLLSYVPIVGDYRRCRDLLGTVFSISEQVSDEDCSKVIDWVLWRTYVILEVTKCSFHVALKFLKTMAVLLNKIQTTSAIVRSKLYLFRSLLSLMKQYIIYVSFKTGSVMTVKEIEASSCLSYLGFLQLKASERLQLFIECIEMPILGQESCVCEDRYRDKYGIYKVCLHCKTVNATNVMTVFFRLQCINEDISDVDNAFCGLSEEFGVFFAELKRCANTSSTECMEGLYQTFDGEISTDLFETLYALTNALLVSGHREVACNTVFRLLFDRSSRYNLLENYFVYKSIFSLFGITNDASDDGNAAVLAHEASRTANVGNSCLQRLSRDHTTACSYSRSEPADPDYLDFIRTRNSGDGKVTLALVLKAVRCQLNFMEAVLNLMSIMRMLPLNFSKLHIGIAELTEALCDQDRAASLIQKILVRIIDKRPSVDDFRMCIHALQDIAAHINGLSLQDLHMMFFFTICISSSEVGYLDAQIQVWFASSSKGIDKIGMFLMASLSAVKAVIYRLSGEQHVNFAMAKLVTELSHGLHEGAADWKYLKHPIYESAIKMHEMIQVYLDFLGIDWDGNLVNEGGSVLSFIESGDNVQYIPDYEIIISDIRRLGMFQRISTVATTTSLFSSNVQGKHKKLGYNLYNNKTELMEHALSSLAACYLESAEKASPDTETYWECRIFASILRGAYMDGGEGFVYGEGQMTKRLCQIRDDALLVLPAKARKDILAMLGLILNLVQESQSHGNAESSAVESAAMSVLMWRLLASSYVRSADFGGLAKLCAQFANDELPAFIRFLKENTFHIAPIQLDSASEASDLCASSITLFEVITGPDCDTESTQNAGNELVVNDFVLRNCILKLLGKVNLAKIEVCQPDKMKISFDKLAHRFTGNTASVLLSKALGKAETGLSSINLKKMQFETLKGKFFSSAKKSTDIFDGRFLPVLNFYNTAVLCITDYDFSDPAKVGDGKADDQDVIRWRSVVRFDVVQLLRVDVELGVMMMLEMCNFTMNILFIEQMHKIFHNINVHLCMRIIQVLRSRLSKLGWHQSLIAHLESIEGFLSLFLVFPGEVDIYIGRFIASSTYRADFFAQVAEYVLEDVNAFLQIYKCLDALFSCKEADRESSPSFNAPLGLGDLTNALWTNICLPEHHCRITDPLIVSEYVSILLQSLEKTFWASDPDDLLDKIRSIEPEFLNFGAQYRNCLLSMYDCYVQKRMHKPGNWLCWRKLVYRYLQVYPEEETFFGDLFRPASNEVLRLLEVVERTTDGFDITEVDDFDMFKRQLLRKVNVRNYFEIVNAMRHVDGEAAKVLLEFVRSDIHGAEYVTGFNAARALHSLDVETASRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEY1</accession>
    <name>A0A061DEY1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucose-6-phosphate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="2">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0405550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="2"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770256.1">
        <property type="nucleotide sequence ID" value="XM_012914802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEY1"/>
    <dbReference type="STRING" id="5866.A0A061DEY1"/>
    <dbReference type="GeneID" id="24566611"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405550"/>
    <dbReference type="OMA" id="MYNNEFV"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="9">
        <location>
            <begin position="103"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="380"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="580"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR98070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="872" mass="100071" checksum="F0DDDB517AA8E2A9" modified="2014-09-03" version="1">MDSEDQVPNVQSLKTLDEQTRESLLPRNPVMSRTGSSTSLSSLVTTNTTHYQNWLKTFYANKLNEVIHFREAGHVVTNYNYKMDDGDDMDDIVEPCLLDCHTEEGFVMAAMHLILHRIKAKQAESPTSIVTIGLSGGNTPRAVFRYMSNMENLDIDFNRIIFFLVDERYVPPTDELSNQRLIRNTLLKNWPVPESHIIFPDTTLPLEECVRKYEADLERVFGKLEPSATAAVDSSPQSKVVGMAMSKSTLKPDLITLGIGDDFHIAGLFPEFLSTLEPSQVTDCKERVMITHTDTAVVHDRLTLSLPFLCCAKSKLFFLKGERKKRIWTTMLQYRHVDPIRFPATQIFTKAGCVAVLDSSTIRRIRRKVPLEQSDCLTFILFGSTGDLARRKLYPALFHLFYLGFLPTKFRILAVSRSHQSFDEFFETVSKDIFASINTTIFMCEAAARFDFPTVIAEFKKKLGRVTVKYDNPQSLVQLNESLNEIESGSTVTHRLIYMATPAEAYHPIMKIATSVCRPKEGWFRVMLEKPFGRDMESCQDIQRVLQQHAQPEEMFLVDHYLGKPLISCIIAIKRSLRYNHLFSRRYVKSVHIKMKERIGTFGRNYFENYGIIRDMVQNHGLQLLSLIAMDKPDRLNDSVADEKRKVLRAVRTVRLEDTIIGQYTESEDGSECAYLQEKGTPPDSLCSTFCSMVMYVDNDKWQGVPFVITTGKGLDEHLCEVRLNMKSNFAAEFGADFEARNLVFRVQPNPTVFWSVDSRHFDTQQESEKLVFTSDHDTDNMGLKVEERILRDVDYNLTKRPVVGCYEILLYHAFSGKRNYFPSLEEVSECWRILTPVLHEIDDKRVRPILYPRGSSGPKEQERHLQLLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYK8</accession>
    <name>A0A061CYK8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765912.1">
        <property type="nucleotide sequence ID" value="XM_012910458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYK8"/>
    <dbReference type="STRING" id="5866.A0A061CYK8"/>
    <dbReference type="GeneID" id="24562267"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100550"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000202">
        <property type="entry name" value="Small ubiquitin-related modifier I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="9832" checksum="91B1BFDED71E0EC8" modified="2014-09-03" version="1">MADSSEPSVSEHIQIKVRSPDGSEVYFKIKRKTKLEKLMTTYCSRLGQSPDAVRFLFDGDRIKGDATAEDLGIEDGDIIDAMVQQTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ94</accession>
    <name>A0A061CZ94_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766132.1">
        <property type="nucleotide sequence ID" value="XM_012910678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ94"/>
    <dbReference type="GeneID" id="24562487"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102730"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="108" mass="12269" checksum="00EF53E79E90CE4A" modified="2014-09-03" version="1">MTAQKIHDLQDRCAYNSTGKNAIHNGLLWQHVTNGNARQDSERQWRRTIGAKSIESITENGTRNDRIPYYLTAVLRTNWYLGALQAPQHAIGNSSGSLNHRYITIYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0A9</accession>
    <name>A0A061D0A9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleolar protein-like protein with NOL1/NOP2/sun family putative RNA methylase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0104170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766294.1">
        <property type="nucleotide sequence ID" value="XM_012910840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0A9"/>
    <dbReference type="STRING" id="5866.A0A061D0A9"/>
    <dbReference type="GeneID" id="24562649"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104170"/>
    <dbReference type="OMA" id="DANKERC"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000009">
        <property type="entry name" value="Nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="9">
        <location>
            <begin position="129"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="219"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="592" mass="64551" checksum="4808CB2CE07D6C6E" modified="2014-09-03" version="1">MVALKLLERNDESEDSSDYSVENDEFDDVASGSDDGGADEAEEGLDVVDAENLHGKVDMTDLSAVKGRIESICGVLSNWSSASKSGVVTKKRGAYMRELREMVSAYYGYSDELAEYFLQLFSPTEAIQLFEANERPLPMTLRVNTLKTRRKELAAALIARGANVDPVGNWSKEGLVVHSSQVPIGATPEYLAGHYMMQSAASMIPVLALGAREKVLDIAAAPGGKTTHIAQMMNNGGILYANDLNKDRCTALVANIHRLGITNTIVTNYNGLDLKGVLPPLDRVLCDAPCSGLGVISKDPSVKVNRTVLNLQQNADLQKRLLLTCIDMVNSGSKNNCVVYSTCSISVEENEHVIDHALKMRDVKLVPLGVDVGSPALSHFRGKHFHPSIGMYARRFYPHVHNLDGFFVAKLVKLSSKVPTLTKRHREPRSKHEDASEREPKLRKKHSGKTGKSKAPKDVSSGKQEEEVDPDVTSLPVKIAQKQKEKKTKLEFDEPLPEKKAKSTKSGKASDVVKSTKSGKSSEVVRSTKSGKSSKVVRSTKSGKSSKVVKDSASKKVKKQAKDLKRSSAKSKAKAKTSKAAKHSKSSSKRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0P2</accession>
    <name>A0A061D0P2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766552.1">
        <property type="nucleotide sequence ID" value="XM_012911098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0P2"/>
    <dbReference type="GeneID" id="24562907"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106750"/>
    <dbReference type="OMA" id="VERAMEW"/>
    <dbReference type="OrthoDB" id="363889at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37445" checksum="14382837675E78A2" modified="2014-09-03" version="1">MNTDLGQFLIDFEKDNPLDKMSKDLLSNIKSFDGLVRSDGYTSCPPPKLAPPPGRTSAGPFDFDFNSTYAHNSPQRTPATNRDYDDDAYAWESKHLPSAVPTLATSYTFPLASRVYCNCFFKIVLNHAVAGMYIGKNGSNLKRLQDTLNFKLTQSGRGMKGDFTGVGYPCHRTNTTLLFEGRLVDILMALRPLYRIIQNDRLALDEESKRFIGDRLLNVKFELELVIPLDRKRALLQEAGVRCNRLRKAAGVDVIAGKQNYEWGNIRETIVTLHGFETNIEKACEWLGIFVQNSPAVYNREFTFMDYPKYSLAVPDGSYNQKTGQLLATKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0R9</accession>
    <name>A0A061D0R9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766424.1">
        <property type="nucleotide sequence ID" value="XM_012910970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0R9"/>
    <dbReference type="STRING" id="5866.A0A061D0R9"/>
    <dbReference type="GeneID" id="24562779"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105470"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="124" mass="14674" checksum="183B104ACD999ED6" modified="2014-09-03" version="1">MQEKIKVFELRSKTDAELLKQLEELKQEYASMRVQKVTVTSTSKLSQIGIIRKAIAKVLTVYNQRKREEARKQYSKLSKMPLNLRPKLTRAKRRALTAKQLYLKTLKQRKRCENIPKRKYALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0S6</accession>
    <name>A0A061D0S6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0100660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765923.1">
        <property type="nucleotide sequence ID" value="XM_012910469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0S6"/>
    <dbReference type="STRING" id="5866.A0A061D0S6"/>
    <dbReference type="GeneID" id="24562278"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100660"/>
    <dbReference type="OMA" id="GKWLIEV"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="8">
        <location>
            <begin position="494"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR93737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="638" mass="71380" checksum="B39318E00DBCD788" modified="2014-09-03" version="1">MGTYHRLSKVEGLREGDPEPYERDRRVKRYFSATKVVGSGKETAPVTHISFSPEGTFVSVCTGTKVIFYDYAQQKIVHTFHDSKDFVRCCAFRGDGKVAAVSDDGGWVHLIALGLKSNLKKWRAHETPCHALHFSCTKLRLMTGGDDGVAKLWDTVTGELVEEFKFHSDKIRAVSDFCGSEQLWVTGGYDSVAYLFDIRNNVKPAAKVHHGAPIEFVELSIANNLLLTAGKNIVKLWDLSSGLQLMYSFEPHQRTVVRAFMRHPIITASLDGTVRFFNYASVYQSDFHASDERYLAELRGDEFSSRMSQTLTARSTSYNSDDDSSENVLDEEADVSSSEDSDEPRSPASVSVRGKRAADCLSDGSNFVTPESRIASPDHFTPMSANPDYLDDSETSQSSHVERPTGESASQYTTDRTEALDGTPTEDLDDTTVSLRHVYRFNSPVTALDVTLDTRAIAIGLSSGEWIIRHNAKEETEEVLFHRKIVKVEEDLVEFKPTKLSLLDRLVKTFQYQAALDLSLSLTPDHVYNLVETLVLRGSLATAVKGKDEHTILPLLRFVSAHLGNDMQNTSTLLELAHAIIDNNQWLETCDNTQVIDELRKIPNKINFELFQHNILQSLKGSLDLILNRSSSDKEYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0U3</accession>
    <name>A0A061D0U3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIN2-INTERACTING PROTEIN X1 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766612.1">
        <property type="nucleotide sequence ID" value="XM_012911158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0U3"/>
    <dbReference type="STRING" id="5866.A0A061D0U3"/>
    <dbReference type="GeneID" id="24562967"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107350"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF9">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="321" mass="34806" checksum="B7B9D60081BA47BB" modified="2014-09-03" version="1">MSKAFRESVRNSISSVGSAVKSKFGAAILSKYGWKEGEGLGKNRDGIVDPVKLRAAKHNEGLCYVEHVQLGRKDSDQWHNWWDELYNEMASKSTKVTSVTSTVTDKGSNTENGESDYSHSGDDESAVDASSSELSSDGETSSDISSESSSSDESNRSDGAQLQHHSYNSDIYRKHKMIRVRQDVETVGGGDCGDAVANRRSDSDQEYAVEANEGGHSSDSSTSDSGVCSRTRSSGRRITPVDVLSGSDSEAPSAPKISSIGNGNAENVKRQPRHKRLIASHDNNAADSTAVAEKRTSQGRETDERKKSHRRKRQKQSSNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D118</accession>
    <name>A0A061D118_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase polypeptide II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0108140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766702.1">
        <property type="nucleotide sequence ID" value="XM_012911248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D118"/>
    <dbReference type="STRING" id="5866.A0A061D118"/>
    <dbReference type="GeneID" id="24563057"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108140"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000063">
        <property type="entry name" value="Cytochrome c oxidase subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888:SF9">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01166">
        <property type="entry name" value="CYCOXIDASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="12">
        <location>
            <begin position="278"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="418" mass="48508" checksum="B9AD2060A5C1C559" modified="2014-09-03" version="1">MGFSATARLVAHGQRGRVFRKFRGQPPKRFDWLKNHLDRLLRLGRIELTLPRAKELQQYAEEVVFHAKKDTPESDLIVESMLRSPEARQKLYERYVPLYADRPFFFTRVINQWRLRFSDAAPMAYLEFVDRPGELRPAKPVGGRKLLQVHALMQASRRDYRKYYAFAKSHGMLDSEGNLLSDISHLIGDSESPWHERAETVSTINPQWREHPVMRQRLERIQSVDLRSDRAEETFESTYEEPAERRVPTSNPDLSSAVRRPRFNPPKVAHGEAPAAERPRLSVEERYPLPEKYAENPDLIPKYYAFQSNLVTDEDLQPGMLRQLEVDKRLTLPTRTHIRFLITATDVIHTWSVPSLGIKADAVPGRLHRVNTFIMREGVFYGQCSEMCGTLHGFMPIVVEAVAPETYAAHARKYYRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D142</accession>
    <name>A0A061D142_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765998.1">
        <property type="nucleotide sequence ID" value="XM_012910544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D142"/>
    <dbReference type="GeneID" id="24562353"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101410"/>
    <dbReference type="OrthoDB" id="10539655at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="7802" checksum="F9D129B12F5CF03C" modified="2014-09-03" version="1">MDRSGFEPETFRMQSGRDTPTPPAPLCGPLIVVRRSVIGRGTYVDDGKLKSSFLGTFKKVGYLHNIAVVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1E2</accession>
    <name>A0A061D1E2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ALA-interacting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0109190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766807.1">
        <property type="nucleotide sequence ID" value="XM_012911353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1E2"/>
    <dbReference type="STRING" id="5866.A0A061D1E2"/>
    <dbReference type="GeneID" id="24563162"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109190"/>
    <dbReference type="OMA" id="IQWMTPS"/>
    <dbReference type="OrthoDB" id="366100at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47089" checksum="0A49363FD80EA4EB" modified="2014-09-03" version="1">MAAGEERETRFASRSRISTRLSNSANSVRVGDSSFNSQDYSTSQSFDAEETVREILFRRRNTSEQEAGLSRFRRDRSQKAMHNSRRLGLIMLVLGLINGGLFALLQARRKAYAECTVVVPDRLQRGYEKWVHPITEQNCSGDTSRFEKANKIYIYYSINNYPFHGAAAFKLHSKNQLEGMEPTKNDIHSCYPYHVVSIAGVEKIIYPCGPHLWHFYSDIFKFSTENPDDSTVFLPIDDSLATLSYCQDYTHMRNPPDKSINETFKTTYYWLQENSIAVNSDENSESGENVDTGFVTRKSAQNISAIRTLMNARAGRGLQNGHIIQWMTPSPFKTFKKLYGVLQGPIAFPLYVTMHVTYDAESFGGWKSLSLVASGWPYGKLVPVQSLLGLIAAMCCAFALLLLLTKPGDPQRCVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1N4</accession>
    <name>A0A061D1N4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766228.1">
        <property type="nucleotide sequence ID" value="XM_012910774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1N4"/>
    <dbReference type="STRING" id="5866.A0A061D1N4"/>
    <dbReference type="GeneID" id="24562583"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103560"/>
    <dbReference type="OrthoDB" id="10394692at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="338" mass="37613" checksum="901C0E9B29F4F7F6" modified="2014-09-03" version="1">MVYNALTDIPRNLKEGIDWLLALKGTDSENNMTALGTAIHKFLVTKPVGFMQVPALENVKQISKEFMEQEEIKGLWPISELLERFTKPMDKSPAVFYSKFNVDESDYSNVVVRRGVKPEDIAKDISEVVDGCEKFLEEVKKPDQYESAYSAEATWEASCSENPEDCAAVFVGIAPMLYAGLRSLRKASNNEQLKCLRLYKTGFSLEKVLDAMGYKEADLKSNNNGSYIFKALRSVSFRMLVTLYDLSGFWAFYETDTPVPGGALSAESTLRAKAREFYMGEKKKYGIPGVDVDMGLVNAWNTKTYHNKRPKISTASATGNFQSPGAPTVANLDAASPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1S1</accession>
    <name>A0A061D1S1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0108910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766779.1">
        <property type="nucleotide sequence ID" value="XM_012911325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1S1"/>
    <dbReference type="STRING" id="5866.A0A061D1S1"/>
    <dbReference type="GeneID" id="24563134"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108910"/>
    <dbReference type="OMA" id="QVIEPMD"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="747" mass="83577" checksum="9B5C8308D30DE607" modified="2014-09-03" version="1">MARSRLRAKFQGRPTRKSKHIEDEEISEDEAFNEEEEAKYGRFFQSKRGKPSEDKGELWESLFENVEDTHVDDSAVGSAATAKSESAQTEVAPRPTADSEYAFTRLEEDADLFTEDVSKEDVGGFDWIADAADGDSKYSSLIQKFREIRDDLPDVFREESRAKASRDERKELYSSTKKTASKRWEPVLQHIKRQKHTSYGGSESRTDATCGSMLQLDAETELEKELDAHTNQAYERALHARELRKNKRVNRIKSKNWHKRQKKRDLELYAKLIEKSDDPELTKELLESFEQKRSKHRVLRKRMAQEKWAKLAMRFGDRSVLKQISSAQQQLKDDLTLIKDTIDGVADREGSDSDDESEGSESSSDVESTSGDPDDEVLAKLKVIANPKAEGLPQKGLFALKFMKDVLQSKMEAQDDDDGSGSHQAVALRDKEEDDYDNESIESDSDREEEVGQTARESDAVKPSPKVSDEELKKAMQHIHMALGGGDESGDEETGFWGAVSSATTSAPAEDKEPVRQDARNEPKSSRAEKVEVGVKRESASSGAVESQAPVEPKVDHAKPKIVPAAAGFLSEDTGLDNFIKNLGPAKKRESTIQMAQRLFVTRGDDEAQLSEEESETEEAASDQLKGWGSWTGFGITEPKASKPAPAKPDKKGRRVVKVSNKKSAKLGKYLLHRVPHPHKNKHDYNAKMATTVGPEWNTSKMHAELIQPKTTIAVGSVVKPISAEGAKEYVKRMGKVLQRNRTRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D255</accession>
    <name>A0A061D255_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNAP protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0105060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766383.1">
        <property type="nucleotide sequence ID" value="XM_012910929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D255"/>
    <dbReference type="STRING" id="5866.A0A061D255"/>
    <dbReference type="GeneID" id="24562738"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105060"/>
    <dbReference type="OMA" id="WSVKEYL"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="288" mass="32085" checksum="EEEC89A82DB47EAD" modified="2014-09-03" version="1">MSNPADIERKARKSSKGLFRFFFGGADEDAHDLFNQAANLYKQQKQWKDAARCYLEAAAKGEKENEHIFAASNLHIDPLMRAANIYNQQGRFAQSGRIMKIAAEEFEAKGDHLNAIDFYLKAAEFYELDEFGKVAGSQARLKYAELASQYAEKYADAIKIFETEGHKNLKNQLLQYGVKDIFLKAGILHLVACDATDAQIAYNKYAEADPKFAPSREGQFLSAIISSCDAEDGELFQKAIADFDAIARLDPWKVHMLIKIKATLPAARDDVGAPPAEDGDSDDEIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2C5</accession>
    <name>A0A061D2C5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767097.1">
        <property type="nucleotide sequence ID" value="XM_012911643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2C5"/>
    <dbReference type="GeneID" id="24563452"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200680"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="84" mass="9126" checksum="A8755F132B3CAFE5" modified="2014-09-03" version="1">MRVAGKGVNCYVIVLKMAFCEQKNCSGCVKCAGIRIAIAFAGFIGFSALLVLVLYILGRQYDVSLGTIFGQIRDGFRDSKAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2E2</accession>
    <name>A0A061D2E2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766448.1">
        <property type="nucleotide sequence ID" value="XM_012910994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2E2"/>
    <dbReference type="STRING" id="5866.A0A061D2E2"/>
    <dbReference type="GeneID" id="24562803"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105710"/>
    <dbReference type="OMA" id="EAPYYKI"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="378" mass="43397" checksum="74739AE4A5A63548" modified="2014-09-03" version="1">MANVSEQAVSPEVYRPEPVRRDDIIIQCVRLANVQLGIDVTGLDLQGELSASDFDYLVVDSITGGYTNILHKVTNTKNGMHVAVRIFGHKTDEFIDRSRERIIQHHLCLQGFAKHVYAHFEGGQIEEWLPGEAVSDADFHSYKYSHLIARQLHRLHTLPSQRELYLELHPHISAGVDVKFESDLWPSVWKFYNLCMANIEQLEPIIAGKFSLTELKEVSYSIRSHPNMKLQHIERMQTYCDSVRSPVVLCHGDLSKGNIVIQSEGVTFLDYEYACFMERGFDIAAHFSEFAAYDSDSKMMPSENIQRDFIRFYLGESSSEEKVDALFKEIQPFLIIPNMYWGLWGLLQCVYSSIHTDFAHYSTNRIERFLTDLESASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2E9</accession>
    <name>A0A061D2E9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766453.1">
        <property type="nucleotide sequence ID" value="XM_012910999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2E9"/>
    <dbReference type="GeneID" id="24562808"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105760"/>
    <dbReference type="OMA" id="ESSYMIC"/>
    <dbReference type="OrthoDB" id="407343at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="539" mass="60167" checksum="8B55637FCA76F22F" modified="2014-09-03" version="1">MANYRGFFLRFKGLCARRMDASLVREPTVAVPNEEPRPVEQTEVVEPSTTGDASPSSIDVPLLPIENAQSPSSIATTRESDVEELRLKNDAPLVTEDVYDPLIMNFSPKISRLRAEAADSDTCKSPTRDVNSISQAAATSTSSGHTAEQGVFWYGITLFSDVGSKPMAESAQKNHVSVLDDRIKTRTSPDFSPSKLAKCRSSLRYYDLMGHRISEDWADLNSRVYDALLQYFTGSDLTAGQKISKQWSDNVRLLMGKKTAKIVAAFKVAYQGQLDFESSYMICQSVFTAQKGMRIDLIIRARVLAWSVNSKNTLQYTYSYIPRSTCDDVGARQPTYANRFVFECLRRNTRRTVSFMRDVSSVHGDDLHVATAESVSQVCEGDSIEIPVVLMNALGNTNVDSIKFLPMRREAVEGEPASSLDKMHREWYTVGPNSHYLQQLFPADIVAYNLVQPEKLQPELEHQVTQVAGIDVITSRSRFIAAKPGPVTEAQNFIGHTMEVIDARQPVVCMLQRSGVQCDRLCHVQLRVGDKVRFYTTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2J0</accession>
    <name>A0A061D2J0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767182.1">
        <property type="nucleotide sequence ID" value="XM_012911728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2J0"/>
    <dbReference type="GeneID" id="24563537"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201530"/>
    <dbReference type="OMA" id="VYINTEM"/>
    <dbReference type="OrthoDB" id="366443at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="490" mass="54589" checksum="78B72CF68CCBA487" modified="2014-09-03" version="1">MDDMDGRRDSREEVIPDASAEVGRTYDNVESPVPGNGFGEHDVPVFSPKCPMAEMEKEEPKGSDVEMGERRQSNFGADASGLTPSRGDVSTGDYVRPEVTIGTFQRDFEDEEEEEDRLFMNPLDPRIDDHQYRLRMFAIFGFLPFFWVGWLVGAIYGCVKKGTKPIHKKLTVLLSQLTFIVGVLITVLTLAIYFTLPVTKQDNLVIQMQPLIPSGLTAGVPLLEKSKKCGALTVDMYRRELKVKFGSLFADVHGNRPSDKTTVFVFKGLDAEWSEHKIFTGEFGAQLPNEPAETYSAKDDIFAVNITAGDPSTIRDEGTAGNIYGLPKLNVLMKCMDVKAKKIHLVATFDDKDAGAFKPDESQDPYETILAVGLFEPTDTTYLGNPAIPSYVGFVNKQIMCNKKNVYFPVEITGAKELSYEARNKGYGELKKYLTDPAKARSLTAKPLNLGFSYTTRELLTKTQTALKALMEYEKVKDTASESKRFKSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2L8</accession>
    <name>A0A061D2L8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766493.1">
        <property type="nucleotide sequence ID" value="XM_012911039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2L8"/>
    <dbReference type="STRING" id="5866.A0A061D2L8"/>
    <dbReference type="GeneID" id="24562848"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106160"/>
    <dbReference type="OMA" id="CWMTLEP"/>
    <dbReference type="OrthoDB" id="361335at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="852" mass="93535" checksum="2E1C37F36EE36525" modified="2014-09-03" version="1">MTDTNQSTSAEDQWEACISYRRSNVTVCRNLSHLMYRLHTAPNQKLKFILSTYCISFEKSYRASKVDAERLIMALDPEFLALMLRSSLVIASSALTLIISLLSNKSTARHLSTLTPHVGVLVSFLVDNKGFEIDSTTSALIKQSASSVEVLKARLVSDCLSFFHSVADVLGLPAFHVIDMDVPDLADVVDDLSRDMFDLVSDDGTPNNTANVTAACRLCELVEHREFKEVASEVEHLERDLDALAAAHLEDVAAASAENDGCDDDGHSLGALLLTVGKSVLAELSKKEQIPPEAISINLLSLKCALELIAAAEFDELFRQCLSSGNFDIMAVLFDLCKSSRSGLFGSSVQIRVAQVASTILEHSSHKSGIALASCFLGQMIERHGFAAISSDQDDCGVNAQLIKRLYALVSRCEIEIHLTLHDFLRLGSVSTDVNASFRLLESIIVCIGENESIMPACHDLFAVIHRTMTTVLEFFDEIDDNNGKKANPLLKCCCRLIGCWMALEPMHLRSLYLSKLGKILSVTSPEDFNWLLPSFEYLDAVDFDGIKALMPSCLAAMSLAWATVVGDESTGSTDGEVRRALSMCYRLLERMFIEGVNDCSAFLALDAADAIPAFTPFKMRSFNETILDQGNTHFSPRIPLDVSMPIPIDPASLPGSAEGPCRVLQFMQHHFLSVLSRFHPKLQPLSGSEEDNFLDLGVVQEALENSLKNESVLQADWSPILCEAALATAAVCLLRLGQSYVREWMNSSATLLLMECVAMSFAYANPRTTAEYSAVDESSGLLWHRIALCCTILLQRQPQFVNVFAFVCRKLRLKPFKATNGKLDALVESGWLSADCASACEFMCTLVSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2P2</accession>
    <name>A0A061D2P2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="4 16">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BBBOND_0202030</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 16">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Apicoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4 16"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767232.1">
        <property type="nucleotide sequence ID" value="XM_012911778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2P2"/>
    <dbReference type="STRING" id="5866.A0A061D2P2"/>
    <dbReference type="GeneID" id="24563587"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202030"/>
    <dbReference type="OMA" id="CYDRNDS"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020011">
        <property type="term" value="C:apicoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0933">Apicoplast</keyword>
    <keyword evidence="6 16 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="73"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="243"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="511"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="610"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="693"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="746"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1113"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDR95046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1207" mass="135530" checksum="C9E30ED2B241C6E1" modified="2014-09-03" version="1">MANGVGIGPTQYVSSLRGPADFAMETQNTAFDPDWMIDKTKRHGVVNYSKPEADSFTDEDSWKVIGSFFNTHGLVHQQIESFNDFVTYRMQEMIDQHPPIEITPQPRYHPADERENNILYKLKFGQLSLNKPCVEEKDGVLKHIWPQEARLRNLTYASQIYVDIEQETYLVDENTKTEVLQEKLTYPRIGLGRIPMMLKSAYCWTKSISEDDLADVGECPFDEGGYFIVNGGERVLIGQERMANNYIYVFKKKQPSKYSLVAEVRSQPEFSQGTTPFSIMMKSTLGIAGSRFKSHGQLVASLPYLKADIPIAILFRALGCVADRDILQRIVYDFEDKQMLTLMRPSLEESADYATQEVCLDFIGKRGPTVGAPLEARIQYARDLLRQHLLPHVGTEAGCEGKKCYFLGYMVHRILLSRLGRVIEDDRDHFGKKRLDLAGALMASSFGTLFRKMVKDTKRILQQQIDCGREFDVAGAVRSATQITQGLQYQLLTGNWGRDREGKVVRTGVSQVLNRLTFASYLSHLRRLNTPLGREGKVAKPRQLHNTHWGMICPAETPEGQAVGLVKNLALMCFISVGSAASTINEFLCEWGMDSLDEVPPEVIKDRIKVFINGTWVGCFDEADSLVKTLLELRRRGDIAAETSIVCDIVSQEVKIFTDAGRAMRPLLIVENGNTLAITKEHIARLDNNECTWDGLIESGVIEYVDCEEEEMCMISMFAEDLKTNSTYCSTYTHCEIHPSMILGVCASIIPFPDQNQSPRNTYQSAMGKQAMGVYATNFNLRMDPLCHLLYYPQKPLVCTRAMEFLRFRELPAGINAIVAIMCYTGYNQEDSLIMNQSSIDRGLFRSAFNRTYMSEEKYVGSAIVERFERPNPANCIGLKRGDYTKLDADGLVEPGSRVLGDDIIIGRTSPCTDEEDENLRQDCSCCLRTSENGVVDTVLLSSNSKGSKFAKVKVRSIRVPQIGDKFASRHGQKGTIGMTYRAEDLPFTCEGIVPDIIMNPHAVPSRMTIGHLVECLVGKVGACCGMEGDATPFSKLTVQHVAERLFECGYGRHGNEALHCGFTGEMIVSKIFIGPTYYQRLKHMVEDKIHARARGPVTMLTRQPTEGRSRDGGLRFGEMERDCMISHGAAKMLKERLFDQSDAFRMHVCDRCGLCCIADLNRSNFECTACDNKTQISQVTIPYACKLLIQELMAMAIYPKLVLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2V2</accession>
    <name>A0A061D2V2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEAT repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767124.1">
        <property type="nucleotide sequence ID" value="XM_012911670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2V2"/>
    <dbReference type="STRING" id="5866.A0A061D2V2"/>
    <dbReference type="GeneID" id="24563479"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200950"/>
    <dbReference type="OMA" id="HAISMFW"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="715"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="795" mass="88101" checksum="271B91A4B9BE2A89" modified="2014-09-03" version="1">MESQDPGPPQPERTPEAELAQEPAQNDVEHESGNTVGDGAADATADPPTAVAKPDEEGAVAGKPVEPETSTAVNTNADSSSADVPRVPALEYDVAKMSISIASRGVGARHPKRVVKASPEQNGTEAIPLGDIPRASAVEHIPHAVNGSAALGKMDVIQPSSTTRVTFAGSADMGSSEKVAEPVKINAPLYPAFEFFKTEVQGGKEGAMEALMHVDIVTQQLGPELCGTLLVPFLAEAQHGMPIQLMKMAMDVWCTLSKISFAEAYVDAIVQGVSSLISQEDPDIRNRAVELIVNIVNDVRSSDAGYDVMASSVMPLLKRLSESEWFADAVSACKLIPLLYLDASEQHQEVLRQCYKQLWENSMLIVKLEVARNLETMLAIMHMDHAVSMFWLVLKNMSIDHQDEVRAHCVGACLAFAKRCTPEQNASLSYPVVQAAASDSSWRVRKALAVRFDKIHEVFGEAEMAAHFMSTHVALLTDDYDIVKEAAVESFLRWCRRLSPPMAQQYIAFFESHLGDYDSKNRQLICRIFAIFAAQMTRGNVHERLSPVLRRLLRDDCMDVRLSAIEHIEALCNGREFESGIGASITETVEQVLQSTRWRHRAILAEMINSFYHHFGRTVFERYFLRMLFQLLMDPVWKVRVTVVESIEALCADCKVPWVADTILTEIIKMYVEPRSSCYVKPEDVPLSYALKIVIIQALVAVTKSLDLQTTLARVLPIIFNATKDPTANVRFVAVKGLRSLFIIYQGKTVEAFVRARALLCKLLQDPDIDVKYYAHMAINTYDACFPSLLQRDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D387</accession>
    <name>A0A061D387_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767397.1">
        <property type="nucleotide sequence ID" value="XM_012911943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D387"/>
    <dbReference type="GeneID" id="24563752"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203690"/>
    <dbReference type="OMA" id="SLSKWRF"/>
    <dbReference type="OrthoDB" id="360727at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="886" mass="99200" checksum="F53CFA1B1AE4B8F7" modified="2014-09-03" version="1">MFCRRLLRWRALSTHARNVIPANAELAAGAYEPPPFDFEAIDAILQSRAKKTQHESSEVAPSSISTAQPPSKERGIVLENDEKSLFYLFLRETNAVIFAATALAKKGKLLASDQPSEGQFEKTQSEWLCERMADRLLSYSVDNRIIVLQRSLAGWHHSRQHHWHRLAKTALRSCFLNDEFPNAQHAAKICAALSKWRCRDIAEVRQKLNLAILAAEGWNVDKASHVLWSLTHLREFEMSAFDYMNNVVATALSKPDFDATSLMDDTVHRILNANIVRMSHTGRQHRAVLTVLRVLTEQPHAVSHLSPKTMLAVSAAMPLCSEMGITEHIARRLSSSMHNFTHVQAAHVFYNFALVAPSLPSAVVDQLVGALFDFKETLYKTEAAYVPSLTAKLLFTFMTFLRGLDHCFISKCLADLNANLHLLGPFSLVGNLQYIKLYMDSSTCDLTGQQLTSLQNTWNNMVKTDDYGDFVKPLFGKDGQAPLDNLKLWHYGALYRLTKLGYEPMMRQIDSFRCGVGTDNVTPAMKDFLLFIVNVSAQREVIADRRMLNAILILASHLRDMSDGNARAEEYWEPVKFHMAALGILDIFERECEASPSSAAKSGNDIPTMTALRLAMTESTGGCDADPIFAWLRSKALGATAADVEKDALAVRYVMFMCLIRDNFIASMLKNASDEPIMKVLKQSFYAGACGRLFHPKDSTDPVVSEVLEYLNASSQIPIVPVNSGVAHAKLFFMQDTPRLLLQLLPEVALAELCCQQRHHVELWDVAAWLQGSKQSDSLCRYLEEVGEAKPLNSRTSFRELAGNVDRPLFEVKRVRRNFNFGPYMCHVGLFGDEDSHIALLFVHTLSGVGGGDRFAEHIFDVQRRKALGILGVQYIDLLKLTDGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3D2</accession>
    <name>A0A061D3D2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767427.1">
        <property type="nucleotide sequence ID" value="XM_012911973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3D2"/>
    <dbReference type="STRING" id="5866.A0A061D3D2"/>
    <dbReference type="GeneID" id="24563782"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203990"/>
    <dbReference type="OMA" id="YAICACL"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="583" mass="64332" checksum="821A15CF349CEED9" modified="2014-09-03" version="1">MVNDGRPWTTATYTKHDQGDAHDAALNELLPQLASGCQVRDSLFDEVLRGLQNDAHVGAKLQALAMLHKSIQAHNGGEYNLEGKILTQEDTNKLATVKALALYVVRPLGAGAFNADNAIKCECAKILNAITMHMPSKSYTRLFNGEALRSVILLMEYACGSRNNSRLEDEMWQAAVSIFKNLLTVMELPYDLVDQTLNCVRGKYDAASAEFCYVLVAKVLLPKLVENVTTGVRLHMQTNLSSMCRRAVQYFAEVIANSNDCQVLSKACTALLCVGEHRFGVDMLLEANCLPGVLKIALTVVYKHEEFLSTLRDKDVYDAATISQMRDSITPQMHQLSFDAISVISKIAYTANRRQVTALLDMGAAEAVVRMLNCPISSVVLMTRAANTLGNLGCESDTEVQIIIDADALPTLVRTYREVHEQNTKVEAAYAICACASRANRRQVGYIVSCTSRSCTIGMCADTQYDTPAGSNSCMALMCEVIDFVCKNDPRSEGNIRLCRVVLSALENILNVGNVEAKTHKLPDNPYARLFLDNHGDEKLAKIAAFPDYQIAKRAIKLSRGFFNTPRLWNIADTDVMYNKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3F9</accession>
    <name>A0A061D3F9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767447.1">
        <property type="nucleotide sequence ID" value="XM_012911993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3F9"/>
    <dbReference type="GeneID" id="24563802"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204190"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17960" checksum="270B88A816CE327B" modified="2014-09-03" version="1">MSKPSDLPIVTVDAISSDSSARPITQSTRRSGNCTWSAVGVNIDTIYPYMQSCGVTYPSDELFKPETPKLYYADGEPQFGREIVLMIAAPYVLDPPNCFDQVSVNGELKGLSEISKSLIASASDHFVILKFDRELVGPGETLRPSPPLECRCITTKGVVLSTIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Z0</accession>
    <name>A0A061D3Z0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765880.1">
        <property type="nucleotide sequence ID" value="XM_012910426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Z0"/>
    <dbReference type="GeneID" id="24562235"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100230"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="7048" checksum="EF786FE78CFA069A" modified="2014-09-03" version="1">MLFCENVRTEENTLFRTQLNSSPNVQECDLKVNVKICGSVLTLRLYVTHIYETLNIISETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4E2</accession>
    <name>A0A061D4E2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767792.1">
        <property type="nucleotide sequence ID" value="XM_012912338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4E2"/>
    <dbReference type="STRING" id="5866.A0A061D4E2"/>
    <dbReference type="GeneID" id="24564147"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207610"/>
    <dbReference type="OrthoDB" id="10647858at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="325" mass="35481" checksum="D5CD5C14573FFC6A" modified="2014-09-03" version="1">MADVNEYDYPVEVEAYSEEGEAEASESFEKELGAEDYEGEFGEDFQAEEASEEGDGELADEEFKADEVTELGDEEADEEGECDAYCTCGDEKEHESDEVEEGEVESPEADAVEEAGEETPAAAAEMEDEGVDVNAEGVDVGAMELVDGMDDSRETSSVVSSEGHVEIPGSLTGEGKSGKRALGKKLQWEAKASVPAYVMKTASKFKVDEISKMSITVKGQGLKNAASKIEALSSAVRETKQKLKEAVNTNKINSQIQRSEVVAAEKARVNAAKKAREAEAERVRLEAIERRKIETLEKQRKQVEFEAKKEALAKARREALEKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4N0</accession>
    <name>A0A061D4N0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767857.1">
        <property type="nucleotide sequence ID" value="XM_012912403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4N0"/>
    <dbReference type="GeneID" id="24564212"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208250"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="53" mass="6314" checksum="5CB9B797DD5366C3" modified="2014-09-03" version="1">MGWHVHDIPQSIWTTLKTDTVKEDYIAKSIAHMYMDAQFIHKPSWMQPYHAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4W5</accession>
    <name>A0A061D4W5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767794.1">
        <property type="nucleotide sequence ID" value="XM_012912340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4W5"/>
    <dbReference type="GeneID" id="24564149"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207630"/>
    <dbReference type="OMA" id="CANIAKC"/>
    <dbReference type="OrthoDB" id="371412at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600607" evidence="2">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="24739" checksum="61DB9EE5D65E5292" modified="2014-09-03" version="1">MGVLAPLLMIAMAGTACGRRDNSLTSVLVRYIAERSAYKKGDQEYARITQAPMVKMHLRKVFLPSTMHAAMKDDMAEKLVERKETQNSHQSHRKSGAGEVDRDNEFARKEITESLGAVDELERLAGEPVNKMVAHNFHEQEFKATFAGAHQRPQNVAGIMQQSTGLSDYAVLPARPVNEAPQPYTLLERRKRKSSELVDQDAERLHVPLFAERGDERVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D504</accession>
    <name>A0A061D504_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767834.1">
        <property type="nucleotide sequence ID" value="XM_012912380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D504"/>
    <dbReference type="GeneID" id="24564189"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208020"/>
    <dbReference type="OMA" id="LGPFWVY"/>
    <dbReference type="OrthoDB" id="363974at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="92" mass="10505" checksum="E37AC0A63C3D3CD8" modified="2014-09-03" version="1">MFSTGLRSIFRAAAIAPRNRACHQAVRHYTKHECEGRGFRRFLGPFWVLTTPVFLHSYAVVGTFFLIFLYPLDSALFNVRRVKAELDSKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D544</accession>
    <name>A0A061D544_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0208420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767874.1">
        <property type="nucleotide sequence ID" value="XM_012912420.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D544"/>
    <dbReference type="GeneID" id="24564229"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208420"/>
    <dbReference type="OMA" id="ISCECRA"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="418"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1118"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1320"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1320"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1373"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1460" mass="163434" checksum="5AAFA107543764E2" modified="2014-09-03" version="1">MTELLPGNLQAQLDEIHALHYIFYPATVQCRGGIDESLFAEDLMPLAEYEELLSRVTVRSRIELYPEVSEEAAPGSLLKVGFRLSPYTGDNSGDVDIAQSFVEVTFPTDYPAAQPGIVVMMNMSLSPASRQSMVSHLDRVVRDTEDGVCVFNAAMSLNELLGDIHANQYQLWDETTGVALDVDHTQITQATLPLPESVITFAGDRLPPGMAALDAPVEFAETKARIYLNPSDGSDTDSPTTSAPYSRLTLSYNENSTVDREMYASSFDIGGWSLQSLVQSPLWYETGRRTVDDSSNEPSSRYRFQINGASRGDDRNWHPLTRNESLNLVAPTRSQRTWSNENEWQTEGTDVATDKTPIMLSVMPQTPSEIGGAGEPRLYGRGDSAPLDPETMLAVSRSKALLDSLACTNSVERYCEDFTETMTILNNGFSSFVKAQHMLDQNLYMVRTYVLPSYCILDTQRSKFDVNDDIERFSLRRKVLIQQLVSSVALLARLQHNSIARYYQCWVEKVQLFEVISQLMRRAEALLDGRLTFTSVDESDDHLSLRQSTQLLLLNSTRCGDEGVSDFLLSEAVTRRRMYIQMEHCDGTSLDQVIQHDALYQNSQRIWTFTRHLLDVLAYLHSNNAYHQALSLQNIIVYTDASGTGLKVCEFGLARLLREFCYSGFFCQHPQCTCRDYARQLRKELFAYHPSTFGVGPAINFDDLSALQGTSDYDAQQEDMFALGVLIFRMWHPPIEERLFKDVFTNIITTQKFPKYFLHSTPPIIVSTIMRLVSADRRPTAVELLRETLVPPVMDGDLYRQYLRRLQNPLSEEAVDALKFFFRRGWKSDLTMLRTDVPLESLSTLSFLIEGLESFMRRRSIVVGPTSVLYPLAPETKGEASVVVLDDCNTVLSLPRSLVRSLQETLRRAPRNGHNLYLKRFTVGEVFDGSSCKLSAVLSCSLSFDVDMMPYQPSRVTKRSAVQPHVLGLPELRLLAMECDLLRNTVDSLESLGLWSSVVLALHFPPLVIDFLAFVFGTNVEVAHDIYTGISTVDVNQYTLWKLFVQCSGSDAPGKNDEERLERIACLLRRRWPVPVALKRMHALVRDSIRGTASPYERAFRKLDADITRRLPVGYDGTSDGDRVLGSGIGSKSSESLSSDAQEPSGALHQLQEQYLRRMGHMVEMARMLNTLGSLEPFCMEFIPESNVMELCEGAIDFPSFGCYVVSDHSEALAVVGGTVVGESGAVQCYAEYLMQTLWSSLDTKVVNTNHVDSIHPDHLDAVITCQSTRLLPAACSLACRLIDAGISCECRALPLIHTDHFHERLRQTGAVKFRIHLQRTGSASPSSVEPCSITHRSDPALTERSAEDEDNGEVLSEQRNLDPSMSHARGWSRAEAHASGRRSDRSATSPSPDGDSSLEPDSSSRRLMTSASSDNDDERHFTGVSFQVEPLRDCYGQPRKIDSSATLVRYVKSLLAREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D557</accession>
    <name>A0A061D557_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767982.1">
        <property type="nucleotide sequence ID" value="XM_012912528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D557"/>
    <dbReference type="GeneID" id="24564337"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209490"/>
    <dbReference type="OrthoDB" id="366235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="13917" checksum="52765942C3BEAA4B" modified="2014-09-03" version="1">MAASAMLGSVAPPPLFTRVADLRAAQLHSGTCPANSDQATSICGGEGGSDGAVACSGDEEDTEGTESGRVARRGKGDDPPPSGDGTGMTEAPAAGAEGGPRPDGPCKNGFKEYGNVYEKHEPTMFGDWSHMGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5A1</accession>
    <name>A0A061D5A1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767403.1">
        <property type="nucleotide sequence ID" value="XM_012911949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5A1"/>
    <dbReference type="GeneID" id="24563758"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203750"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="156" mass="17692" checksum="40D4FD499A1C3A0F" modified="2014-09-03" version="1">MLDNDDTLADREVLGVLRQQLPPQLRNVESVEDLLEYGISVAKAERDKAVKNFLNTKKLMANIKLLERLDDNTRAYIDAGNGIFLPARLKDRRILVHIGYQFYLAMDHDEAYTFASERLKLLQKNIDALNAKVAEQRAQAFIIAETLCTMSAAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5B2</accession>
    <name>A0A061D5B2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid-like peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0209020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767934.1">
        <property type="nucleotide sequence ID" value="XM_012912480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5B2"/>
    <dbReference type="STRING" id="5866.A0A061D5B2"/>
    <dbReference type="GeneID" id="24564289"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209020"/>
    <dbReference type="OMA" id="NGFAGDW"/>
    <dbReference type="OrthoDB" id="360314at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="286"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="464" mass="52384" checksum="5A37A0388A91C335" modified="2014-09-03" version="1">MLVTINVPDGEDPARGTEGVPANASRNEKIEYENVVSRHRRYTVEFERTLAICVEQFNNVLNRFNRKNCVLRCSNSAYNLSLTVDRLESLRREYVACSSCNMVLHCRVTREEAASESAEGAEGQGDARDVAEKARRKELRSFLHPDTHPDGSVHDIFVYPTNNIIRRFRERRTLTTLVRSDANISEMDSTNSLSDYIVYMVRGRIEEQPFFGSVLETLYEVASFLRYNLYPLLRIFKISILITVVQWLLFIIRLVYCRRYPEGIYDEGAELFGAFSGSLLKKDLAVHRLLSSTFLHNSGGHLIISTIMHFRFSSVFESIHGATTTLSVYFLSSAYGMLSTCWSNLDILQANGFAGDWGMAGALLSRYCVFPYLLDREHQHIINVFVSLICLLFAKTIGASSRILVVTHLLSALAGFCLGTMINGRLRIGRCCGLSSLLVDFFCSFTLLLLPIGSTFALFLIPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5D1</accession>
    <name>A0A061D5D1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GMP reductase</fullName>
            <ecNumber evidence="1">1.7.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0209170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.1.7" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767949.1">
        <property type="nucleotide sequence ID" value="XM_012912495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5D1"/>
    <dbReference type="STRING" id="5866.A0A061D5D1"/>
    <dbReference type="GeneID" id="24564304"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209170"/>
    <dbReference type="OMA" id="AYKEYFG"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005994">
        <property type="entry name" value="GuaC_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003966">
        <property type="entry name" value="PRK05458.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036500">
        <property type="entry name" value="GMP_red_Firmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="319" mass="35280" checksum="6ED5B6476C4899DD" modified="2014-09-03" version="1">MEVFDFEDVMLVPRRGVLESRAMADVSAQLGKRRFRIPLMAANMPAIIDENIAIELAKRDYFYVMHRFNIDTVEFARRMRELELFVSVSIGVQPDSYKVVEELKAANLVPEYLTIDVAHGHVEAMRKMIAFVRSNFGSETFIIAGNVATAQGVRDLESWGADATKVGLGPGYVCSTSTRTGFGTRGWQLSAIQECARAARKVIIADGGCRMSGDIVKAIHMGADWVMSGYFYTGFVQTPGETQVKDGIKVKSYYGNASAVNKQSAHRVEGIEVFVPCGGSLYEKMVEIEQDLQSAVSFAGGVCINDVRNTEHVIIPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5D2</accession>
    <name>A0A061D5D2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768097.1">
        <property type="nucleotide sequence ID" value="XM_012912643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564452"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210630"/>
    <dbReference type="OMA" id="AVYWHHR"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1980"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1980"/>
            <end position="1999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2055" mass="227303" checksum="E3D1B86D07769894" modified="2014-09-03" version="1">MAARSGAAPLFSNPLGLSQAYELLTSINVIVVRTHGTSDECYARCVEYLRTRMRFVSVNDLRATQPNYEPGAKERQHERYVLSINQSDTLAVAAEIEASYISAESVTRNILFPDVSSAPYVLGASPKTSAVDETSLFTIRYIEEGFPQYLDSGLFYQGTVSAGIVIHDTEVENNQELKDLFYAEVNRLYDRYGVSVVHMLCRSSRGFELFSREYLCPLYPWLKYSERSHRLRVDTSNDLFSNHILHKSNARETIILYSSCDRMTYFLRELMVHCLVCVLRMLMAALENDRLPESQIVTRYDNPELLNGLSRKQRAQLNTARTLKIHGDIYLMLNNLPKAIATYTLAKQRCKKVQDELFRSSAGFCLAIALSRLSQIKEQEHKDATAAGTGRAALLGLVAQPPTRNTLRCGARNDCCKDDTGDYALTTDVVNAHIAAAARHAAPHRFSAAHDMQSDDVMGAEHAHVRNPRSLRSTPRSPALDAMSSVPGSPQSYYISEHGDAVTEDERNATNTPTVNGSAQHSPTNMKSIRSAGMTMLPLPADFEPQSAQPREAEGAAPYVDKNAERIVRTFTKAATRWLQLARVPGRELEVCLPIMMHYLRDNGHHRHLHWIIARMVELADTCLSAVEYTNVLRYAIDVTRGEPFRRKWSFYNFLYEHRRLANGFAVPREMVDDVVRRFGLVTSLPEEAPASTSICPSSAGLPSVCSLHHQSDIPSLQASARTATPQSQPADNSPSIDPSQSPVSEAATGVAHVAGVAGSAIVHRTQQPGTRATRSLHFEPNSRLSTPSVDHADAAPTARMAPELADQFAEASLSVVKRLAVGQSTVQSASNAVLRYHPRHKRSYHSDASGALLDIAALTDSPFAADAPGVYPRFPEPLERSLERVTRIIGQPSVCNFWRNEGITADWRLTHFFGISRAYIDVAMRECDAYGMRLQNAHLSLISFIMAAERLLLHTSRNRPLSRCSSTTSKPGEEKAKPKEGAGKPEGDSGKPEGGRTKIDGEANDLRSDAPTKDPYNHDAVCHDFLKHHVDQIVANCRVVGTGGRYSLFDFDHVVLASDVSDALTLPRRGHRRVEMSTATARIPINLCYSNRNLLYILGGHGGSNLVVPHVCGMDYVPPRVGSDDVIHVKSNVNMVHSARARHAGSKTDHIFKLRDTRGYRCRCVCDFSRWAHSNGSMPSSSRTVESARSAADAPYGTPRKGALGLPRYGAVSSEPRCRVVNQASSKVPKCKLVKVDPVLAELVATNSAADEPHPREDAKGHEARPRAIDVDVGTVQSIEVRLWNPLPVQFVVEDLTLITVGARVDVVRRSVTVPPSAKEQKVLIRFVTRSKGRVDVVGVTFRMLGFLRCSQVFLRVPPPVVRSTVESVTAEPWSLHERAADLVRDGRGIMFTVGNVVYRPNVSYQSTRITVPRNVRNNLDHVLCSGTRRRSGRHDRSRHPVNFIRTSSIVSHCTQRCESDLYASRFGVRVPASSDASVPQTVRLCYRDTCWICCLTRQKGREMVVQDAPQLDLIEGEERLIYVTVHNDSVNVILSNVAVSVLPVLDEPEALCEVMTLSDREYATMKQRADIAQRASASVRNFTVLADKAVSMRNTIPGLSSINNAESPRSHCSLGSSTASAQPMLQAPAAVLPGTTLYIPILYRAAITASRFHVRVDYEYSERDGPVRAAIYKRINLAVSKGISIGQMGMIVKPRVSFDIAALVATLKQRHLQLSTLGALQMYKHVFDDQEVDVILSVANATDEPFLCLSGGANSAFVALPKAESHWRITARRLLYVEAKRMCPFSFVQLLDHHMALRWSLGEVREGELRISDLTHQKPKPMPGSRAGRRLFSKREYKTAVLRQCTRPALWRMKVAGRPLSIVRYSRVPEIVHTNLHHLVESKITMDISVTADSPGAVSAPDTLLNESCVTTMEGTPFTVKVFARNNGDVPVHSYTTVIVPFLYGACGHPRGLRWTGALEQVGMQHLLPAARIVTRTPAPTTSDVGSPRSQQHQGSPSPRGIEILDRQVPVAHLSLVAHESSIYGVTAAIVVRRDQAVYWHHRPVVIHVVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5N5</accession>
    <name>A0A061D5N5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767493.1">
        <property type="nucleotide sequence ID" value="XM_012912039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5N5"/>
    <dbReference type="GeneID" id="24563848"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204650"/>
    <dbReference type="OMA" id="YDFSNGY"/>
    <dbReference type="OrthoDB" id="360859at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1148" mass="129328" checksum="D0C58F7EC5CE24F6" modified="2014-09-03" version="1">MPTWALSSASSFYRHVLLEDVSRSGGTNDPERVRDWFLRYVLEPDPLTVSVTYDDPRGDNDAQSAHRDLAAIAHVGNSSVSARVAAFHGSSGLCRNGLYCMPYESTFYLNQERSHLNFNELNHSSFYDLMQCEIVNGMAPMYTWGRKRVMLLKPTGAANGGIEAVEVMARSAEGSIELETNVRFKVYPSGIFYPKRRAKYREVNAEASDAESEGSNSDSSESDGDSSGDEGHQQTSQEPSWRIKMPFERHVNPQRGMFEAAYDFSNGYFTPYVDTEPTVTGDTERPYPHHLYRSWKNVSSRDSHILELRASANIIYARSFNGFYVGRCIEEGRDWRVDTLNNQQYGDRDKVYFMHPNPFIPSECAMLASNTLLLYDASQSKERKHLTLQLPTCEGQTVTDVVHTVAFGMNMNELILGGDHLYILDMRTDKIEELLVKPNKEIRVTSTRWTERLYEPTTTANRSLAGASCAGSNYWRNAKPSFWDAFTAIAVHPVYRHIMACVCGRSNAIYIWDLRVPIKPVLEIPLPAAEYLGARFRELIWSASEESNGESTLVAFSWRQRHPITCRFRINRTITRFVQDTGPAKERQFWNGWMDLYDPVKQKQLDRLRGVRPCKLAKAEAGRPPRIARVGPVPKQKPVPQNMHYYMYGMPIHRYEEEDDLQQNEAPDDGAADNEDSALADSRLLSDFASGKVFANDLELTLIGVRPMQVMRVSKGDLEANMDSVGPLIESPEDYPNMIFKAPQHEVAVSIFHGYCGVAVVWCGNEKLLFACTTSGSIFAMDLQMRRQVRCPVASRSNNAAKTTSKGGELFRYVRRIQGSVKLPREFITDEVRWIVLHPNTSEVKTPPIPIAVLGLSKRFVEMQETDHLPLSCGENTFDSRSLLQWLTKQQIGAASGLRKHDIMSLQDFEDHIGSRTHLEHLATNVWDCNDMKIDFEYDAVNVNNKYLDPTPPCHCFTSTNADHGCEILSSYIKALKVNEDGEVTVEPLHDVQEASQSNKGGCSTMEDCLSRAAASVSKQSIGVEADGIIHAREIANTVLFHSPVLPEINGASDVPPEPPNEDDGVHHRFCGVGHLIAIKLREEHTDDKNERIEQLLGSWRTSADTGGGTMGAGITRFHKQSNQVELLRRSQMERDHLVQQLLLQSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5N6</accession>
    <name>A0A061D5N6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766450.1">
        <property type="nucleotide sequence ID" value="XM_012910996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5N6"/>
    <dbReference type="STRING" id="5866.A0A061D5N6"/>
    <dbReference type="GeneID" id="24562805"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105730"/>
    <dbReference type="OMA" id="RWANRAN"/>
    <dbReference type="OrthoDB" id="343702at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="387" mass="42669" checksum="DA09C001A4DFC701" modified="2014-09-03" version="1">MANTLFRGELFFTASELESFHQRLKELWDAASKDDAAVDVPWQLAPLDAAIPRGHYHLLSEAVDMNASLPPKRERSNNIQLKKNASRRTLASDIPGHSTIDDDIDSLFKEIMDEGFDEMEGPFESHKSAFPQQEETVEYDNTSSLFPLLNPDDAVLTSMPTWLQKLHHVVASLCHTKSGSLFAAPIEGAAEGTFETAGEEASPMPPVKSVTLHIVLEKVLQNGYASSTEAFAEIYAMLLTMFKFQAPGTIPWMSTHDACCKLEKLRRDSNLVDSETAHVSFGGKHLPAANPMTLPRQLPASLDFVAEIQPVSSQEKAQFQDALMALPEDCHVELYIAFEHLAAWKILGNGEIELDDEATNSNVFRYVSFLTGTTPQGYDALGTATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5N9</accession>
    <name>A0A061D5N9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767498.1">
        <property type="nucleotide sequence ID" value="XM_012912044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5N9"/>
    <dbReference type="STRING" id="5866.A0A061D5N9"/>
    <dbReference type="GeneID" id="24563853"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204700"/>
    <dbReference type="OMA" id="MHLPYIH"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="335" mass="37331" checksum="2073F238592A9BD7" modified="2014-09-03" version="1">MRRHTHAGSWYDDDADSLQNEIEEALFTDEEVPLPPPKYIISPHAGYTYSLKTAATAYRRIDVAKIATIFILGPSHYASLRGCGVDTFSSLQTPIGVLQVDTDITEKLLNEDGFVEISRVAAEREHSIEMQLPILRQILNRQVSIYHYRIPFRACADHVKFVPIMVGSMDAKRLEKTGTLQPPTPHSLSRQRVASLLPKQGTTQMTAIDETCGRIQCLSSLPIFATLETGYENESIPLWQAIKKLDMDAVDYIIKHDLDGFREYLEETGNTICGCNAIKVLLMLIKLSGMSIRSEMISYTQVNHATAPCIAMQSNKCEGIHDCSVSYCSIAGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5P5</accession>
    <name>A0A061D5P5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage stimulation factor subunit 2 hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0204800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767508.1">
        <property type="nucleotide sequence ID" value="XM_012912054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5P5"/>
    <dbReference type="STRING" id="5866.A0A061D5P5"/>
    <dbReference type="GeneID" id="24563863"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204800"/>
    <dbReference type="OMA" id="LHTQFIL"/>
    <dbReference type="OrthoDB" id="366430at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031721">
        <property type="entry name" value="Partial_CstF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15861">
        <property type="entry name" value="partial_CstF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 2 hinge" evidence="2">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Partial cleavage stimulation factor" evidence="3">
        <location>
            <begin position="342"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43894" checksum="D935508CCC13464C" modified="2014-09-03" version="1">MGSHQNPMIPPDMPPMMPYDMSLFEAAGMVPPMYAFQMPPMGIPGVPIPPPPAPHQLGLDAEDYQLEMAAMAGEMMSQVKFCPPPVAAQFVVPHQPLPPQSLAAERPDVHQTVDSYLAAEIASVVHTLTTSQLTHALAAFKIFFEKSPTNAKRLLMNNPQLLYALIHAQYVLGNSDKSLLHLSKTDQQIAALNRKERLSTGSEAASSTEERSESVTRHTAKRHRSSTPNEAADEKVDAPAPDVETGKLGGSSRRREGKTKEGSVQSSRRGPKVHKDGDSRSAGHATSRAAPTESQSEDVASQSRPAERPVQTAAESGASHAAQSQSQPDTPAPKPVAMVTTIEQLIKEVQPAPPILVEEVLKNTEILTNIQRATLAEMQSWPAEQRLQVMSIKLALHYRGISIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Q1</accession>
    <name>A0A061D5Q1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0204850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767513.1">
        <property type="nucleotide sequence ID" value="XM_012912059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Q1"/>
    <dbReference type="STRING" id="5866.A0A061D5Q1"/>
    <dbReference type="GeneID" id="24563868"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204850"/>
    <dbReference type="OMA" id="EISHIMA"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31030" checksum="4E110C023E9DE06E" modified="2014-09-03" version="1">MAANVGRINVDYAHVEIGEFKDTVYCPCQDTFLFVDALQSDIEHLRRREIAVVMEIGSGSGYISAYLLKLLCDNGETGAVRATHRRDDGYYQCAEGAYDVERSVCAPSCKYSPPFVIAVDINPFANAATMQTLNSNGVAEKADAVGMDMFASLNCRASRKMVDVVMFNPPYVPSDGDETANECLDMAWNGGAMGREVTDRFIGSVKVRLLHLRNADTCNAGILIAQRNSLVEKRNDVNSVLQFIEKQGFDAQVIITKKLLGETLSVIRFCTKNTDALATQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5V6</accession>
    <name>A0A061D5V6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0210910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768129.1">
        <property type="nucleotide sequence ID" value="XM_012912675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5V6"/>
    <dbReference type="STRING" id="5866.A0A061D5V6"/>
    <dbReference type="GeneID" id="24564484"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210910"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="187" mass="20811" checksum="53FB1A437F19585E" modified="2014-09-03" version="1">MQRDKVEALTKLGANAFAKMEKINSELLSLTYGSIVCQLVKDVEFTDGVNTQLISMGRNIGFRLVDEVLAKLGCTPCTDFRTTVEVIAKVGLKMFLGITGDVIVVDEAKNHYHIAFQENPLDQFVELPENLSGLAYSNIICGVIIGALEQLQINVKCEFVKDMLKGHDVYEISIKLQEEIMKQSHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D605</accession>
    <name>A0A061D605_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ImpB/MucB/SamB family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0300460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768327.1">
        <property type="nucleotide sequence ID" value="XM_012912873.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D605"/>
    <dbReference type="GeneID" id="24564682"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300460"/>
    <dbReference type="OMA" id="VEPAKYM"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="475"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1302" mass="144884" checksum="D195E93C594533B0" modified="2014-09-03" version="1">MALPVKFGGGGSFSSYMERRRRGVAAHYQRKYAGEVNADEQILPAIDAVPCQHVGEECQCYSAGHEGRQLSEGQVDCSVVNNDEVIGCDSRDPGHSPAGNNTREGVSRNTGAYTRQINDSPDCALSPLFKGCHFYIDGVVHPYIRLGENENAATSAVHAHEKLIELIVQRGGHVEIHLSDYVTHYVVERVALGCSKWWNMRERGGEYGHYAIVTPAYVFECHIQDTRLPEREFLPASLRSKSDTITLTQRWRSEELKDTPNQCADGFNDDERPMQGDECGEHPVGQKTSVENTKAKCDTDSDTEVPRDEQPSKYTDWDQYDGPIPVDTRNGGNYVNATLANEENGEKSIISGVDPNNSIDTSAIKRPDTMSVDDISHRSPAADKDVDTCVDVKRPASETVPTSPIVEKDDDALGNDTDCLMNSDEKGAGNGIAVDEYYKRSRLHLLGTWKTNVEKEFAFEPFTELKEGMLTNGRYLHIDMDAFFVSVALRSRPHLKNLPLAISHGTGRNSASEISTCNYEARSFGVRKGMWVRDAIKRCPLLKFVPYDFDAITDTALKILRIVAGLTKRVYSASCDELYVECFMGDSATDIANYINFAHNIAQMIERETGCPLSVGIGANMMLSKLASQRCKSLKHGGNESTPGCYRQGSVCAVVDVDAFMESVPLRELPGVGYRAMALLQSCGYVSCSDVHDREELKGLLGDKLGNTVYQFCRGLDYRNINTAEKRSHIVKNKTISAAINYGVRVTEMEQVHEYMRQLISQTWERVEIASENLRGQEADSGIAGIAQAQITLKLRVRSPEASVEPAKYMGCGLCDEYTASVAGDLLSQKSVLASLKACWKKITAKQSILLEDLRGIALSICRIKRGSAVENNTIDRFLVTVTSSPSSVGNYPVYRDTPSRMNTPQRSMSDLCTSDSLNDSNSEYKESILRFMQVSPRPMRTPVKRKRSRCRYVRQLTIHDVLSGSTLSDSKCESWSCHSVSTGRDYTITADDRTKFVKRPRRNSFVEMIPIMPSLSSVWVCDASIRIIEQRLRAIWRAWPIYNGVVNFYREIFANYATILGEGADVAETSNADTTNTSETIPPTTNNDVVCINEGEGISFDGANESIGRSKEPCREKGENEPQENECDHTPHNNAEADSCDLANSGHIDGEEPALDERSDDRCVITPFQLRRVCVRCRAKFFKSFDIGMLCDVDCNADICCLPRLKSLKRCKSEADYTAQAITMVICTLVYATLLRAVVQLSRKGHFDVLQVFIRISLREAVNVTASFVRELNRPLQTQFFAEAQSHLLKAHNLSMNSIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D627</accession>
    <name>A0A061D627_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRP12 HEAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768199.1">
        <property type="nucleotide sequence ID" value="XM_012912745.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D627"/>
    <dbReference type="GeneID" id="24564554"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211570"/>
    <dbReference type="OMA" id="YENAFEH"/>
    <dbReference type="OrthoDB" id="361182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 HEAT" evidence="2">
        <location>
            <begin position="585"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1286" mass="145227" checksum="B99E540BDA0F2D32" modified="2014-09-03" version="1">MASSEISHIVATLIRRIQKSTALGYDAIADRMQPSFQEEDLAMYEEQVKSDRFGRVQQCAFDSLALIRVAVAPMEPTWDEGISETDRQAMMEIYPIIKCSLDCIANQLGDALSNAERHKETTEETSTITFEGLFLIAKTGIEMLNPAIFYVEKSALSTIIEILEKASALRPLLNACTACLTAYLCRLLATDVPSELGEGLTVTLAQLKHVFERTLAMAIADDGDQVNNGTLSVLKITMTTVMRRMKELMKDAANNGSQIAFISKVIDCWYGVLVGQIMQLRVDMVQSSAKPVKLGKLMRIIASFPTLPPAHSLRLVLQIALTLQQDISCAIQTETLTALTTLMDVDVMQAGDVVRNNIKPLSEALVEVLFDRRFCGNSHGATDTTDCERQIQLVYCIAQCIRTARSVSHDKNAKMDEFLQKQVLTLLNTDKPQQADGAARLERMVRETQHLPELQHNFPTIEDFMASRDDCELLTRLTRTFNYLLSYSNQALDEAIALVICWLFNEFEFGICLKLLTPLCFHFLRTKRSKMLDGLHNVNQMPTGIASMVKSATTRWKLGGRIFSVAMETYKEVQEDSSIDVDTSSMKSQAVAIFTALLEATVDIAKETAGNLPKELEDCIGMFARMFGFDDYVRLLPLTPLHSIPITSETFRTESYIYMLPILQRQLKGVPLEVYMKHFMPILTKVETLKAKARDCAAINAANEMAMTYVVRSYDALVGILYNILIGMISSATDCKQTLERNNFELLKHILELLDKSSEGAVVACRLMASAANLEGMAPRLIGIFVKRFVALETTIHTESSDVQANIYAIEDALLGAIANCGKFCESKMLVENLESFEAALRRSNCTFDPLIKISRALLPSVDDQLKLKLHLHWIKLCKTMATKNLYLALKRSCETLATEIKESLPNKQQEPATTTDSPCKEVSVYVKESCSVYGLHALSEALNVKPDAKPNVETEEYSKHRICCIGAFVKLLETMKMHGVYDQATKKFVDTLMRPLILEAMINAIAPNNNTRSSALIIYDGICNLKLEEIGDILKLSISALSCKASKIMQIVLVRCLTRLMARHSQQAVKYNLAQVLQFIFRLLTEDNIKLYVQLLKFARVCVVKLNLDQVQWMAPMLMKMFENQSCCQKAKVYVRRVVQKLMVKLTRDQMLKIFPPTHLPLLRNIMAAQRNKRHSKLRKALRPSDDDDDDDDEQFIDKMFKTDDEGRLVLNFDENDESCRIESDIMEEKGRRRQKKMRQKLRKRGDVQPYTYIKLNKAKTSEKHKRENVKALKSLVKSKVKMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6C4</accession>
    <name>A0A061D6C4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767753.1">
        <property type="nucleotide sequence ID" value="XM_012912299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6C4"/>
    <dbReference type="GeneID" id="24564108"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207245"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207245"/>
    <dbReference type="OrthoDB" id="366307at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="22065" checksum="B252DB5A094BCDEF" modified="2014-09-03" version="1">MTLRWLLEHVSGLVERRCVHFSKPAPNCESSRDPPRRFCRGGLRHHGEWISTCALISRTLRAEGMRCDVFYSTETGRRFVRALESRLCSLNAQQLFQAPIECVVLRELLPQLSRLDTVSVLRLPTLVASRDPALWRVLWQVRRILRVSSVVGAGFSSDRCQKWLRSPGPSGDPSARVVEVWRRQINVQLNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D760</accession>
    <name>A0A061D760_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0302720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768554.1">
        <property type="nucleotide sequence ID" value="XM_012913100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D760"/>
    <dbReference type="STRING" id="5866.A0A061D760"/>
    <dbReference type="GeneID" id="24564909"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302720"/>
    <dbReference type="OMA" id="FVRNEFT"/>
    <dbReference type="OrthoDB" id="364216at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF550">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_44, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="238"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="583" mass="64765" checksum="F8C6E97846CDFE63" modified="2014-09-03" version="1">MGCGRTCAEISTRPTNMLDMPMDGRHWPGEERSPIRYPVDWRAGGYYGFPPRGRYNYIPYAVHPSSCINRPDMASVHPGGAPVVRHHQGPSKRPLNSIFVEGQGGKRVCVVSNGKLDISDKALRHVVQAGGKGPHPSDAVTCSCGVGSIFPRMPMARPGMVGVNMAPISHSRLAASARFMDNGMSYPHMKTVNTCRVPTSSSDSAPGGGRLLPFEWPDKQNVIVYMNHDQEVVDVHGWRYVDTLGEGSYGKVYFVRNEFTGEESAFKRMLLHKTGGISPAIMREIHSLKILDHENVIKLNKVYIGDCRVYLSFPRIAGGNLRKFLEKHYPQGMPLGEVKAIAKQLIDAISHIHSKRIIHRDIKPENILVQTSSGYSNREHDASTYDRQAHSSVGSLPAPQAESGDSATARDPGRKPKIQKVILTDFGLSRIHKSVDLPLFYSDDTKMMNSPMSPEVVTLCYRPPELLLGDFHYSFSVDMWSLGCVIFELITGKPIFEERTEFALLIAMFKRFGTPNEEDWPNVANLPFMNSALPKLQTNSSLSECAGKADADCMDLLERMLALSPKKRISAQEALLHPWFTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H0</accession>
    <name>A0A061D7H0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TATA-box binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0111220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767010.1">
        <property type="nucleotide sequence ID" value="XM_012911556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7H0"/>
    <dbReference type="STRING" id="5866.A0A061D7H0"/>
    <dbReference type="GeneID" id="24563365"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111220"/>
    <dbReference type="OMA" id="VYRMDEP"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="280" mass="31527" checksum="7B222C5C36598780" modified="2014-09-03" version="1">MVTKLRDEEGEYTRLDFLNFLSPAESDDEEPRSTLPPHQSSLLFAMSDVDMYNPKDVSGLDDSALAVLDATACVKSGAMLDKATQYSYYLRSSFDPACLDAPVIQNIVASAHVGRDLDLRELAISTRNAEYNPRKFNALIARIREPRCTALIFRTGRVMVTGCKTVDAAHLAAKRIAKLIRREFGGPLHFAEFKVENIVASFNCNVPIRLERLYEEHKLFCNYEPEIFAGLVYRFALPDGNEAVLLIFVSGNVIITGCRSPDEIQMIHTHMFPLLQEYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K9</accession>
    <name>A0A061D7K9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767060.1">
        <property type="nucleotide sequence ID" value="XM_012911606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7K9"/>
    <dbReference type="GeneID" id="24563415"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200310"/>
    <dbReference type="OMA" id="VGMFCGN"/>
    <dbReference type="OrthoDB" id="365328at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="361" mass="40744" checksum="B80C49381FD4033A" modified="2014-09-03" version="1">MDTFHIGHEHQVDHQQRAGRALARICVLFFMSFAIIIYHFSIDLPDSAPPVEVHKTPGIKFNDAAFSTVKIYVHQALTLPRTTLQLAGMVDIINVEPSRILGIEKQTTLRWERDADNALNLAPSNTVYGLTSIYAHTEKDHDVFTAVMRMPLSVCNGLYYSWTCQKNERHELYDNSYCVVLMQSESLQTILDAARDATQTEKIRLEEPYVIGAFCGNPMLQRITAGRRSVYLLNRKKESQDPDRDYLLCRFSKAHRELSQCTDVGMKKYAFGMPLALMYSSAVDTAVTVQYQDNDTLKLITFDGQHLNPKAILKAMPSSSGFLMYSNSYEGSVIFHADLTLLEVDTVVDLESGHDLTIGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R0</accession>
    <name>A0A061D7R0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">porphobilinogen synthase</fullName>
            <ecNumber evidence="3">4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0200960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767125.1">
        <property type="nucleotide sequence ID" value="XM_012911671.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7R0"/>
    <dbReference type="GeneID" id="24563480"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200960"/>
    <dbReference type="OMA" id="ENVEIHC"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595873" description="porphobilinogen synthase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="13">
        <location>
            <begin position="539"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="681"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1659" mass="182905" checksum="3BE1202E8272F498" modified="2014-09-03" version="1">MGLLRVLGALAIAIHAAAVLERGGSAAGTAMAVALRSCEGCCDVLGPGRATRAPRGAGAFIGSSAAKWKAGSGAVLDGRRASALGRSFAKAKEEDPASTDDDLDGVASDVFEDEVGYDDIYDEDSEYGSEEEEEDEEDEDEEGSTSEYDSDEEAGNSAFDYNARGELMLPNLPRLSRTRVSRNRHKLFRGSVVHLSDLVYPLVVHDKESSESVPEVPGLRLMSIADLVKEVEEARNLGLTSFMIHPHIDKALRSQFADEGLNPDGLLPRAIDAVKEAFPDVQVFADASVAHFSLDGHDGLVEPQTDFIANDVSVSQVAKQVTTLASAGCDVVSLNDTLDGTVGVARDALDFEGFTDVSLMSRAGKFNSVLMAQQRKLLGMTPSENVRPESYLHDVAVDEESIMKGMQDVDDGADLVAVEPATGFLDVIRNLKDRLRSPVVAVHTTGEYRALKAAAAAGVFDERAAALEAIRGLRRAGADVIISSFSKDVAQWLLEDMQTNGMEHPADPLPENPQVVRGRLPNGLEYTLLPNANHCERLEAYLEVMSGSADELDHQRGVAHFCEHVTYMGSRKRDALVGRDVRTNAFTDFHHTVFYASCPSSMEGCGGREGSLERALEALADVVVAPTQFTASRVEKERQAILSEARIINTLEYRKNCATVEALHSETRFPIGDLDALERYSVQDLADYHRIHYRPSNLRLFLVGDIAPESAIRAVERVFAGMQEDRELVDRYMREHADIYQGTVKESRWGLPPAKHIWDQPGPIAHVWQNGQIRNLSLEVVRKMPIPTILTCGDMRQSLLMKLAYRIMSLNFDILQRGAGSLESVEANDYDCTNEGCRVRSFEFRCAPYQWRDALSAAVAQAKCLATQGATHEMFSLVRDSMLLDCSRLDSAKADNRDVIAGLMDAATCGRTVMLPDAEKELVTDMLHSVRLDDVNDMASRLFPWSSGESFSGIHLICSTPPPDPSIGYDGVTEELVADAFESECREPLSAAALNPNVNTPSQLLSDEERREVVGRRPYGEAPSFVANPMLPKERYARPEEPRDEVLRSLAVGGDLRLVSERYIDAVRDSFKLRSDIEYITENTETPSELSRIGERLTEGSSHLVNEREHGKYTQALANLRKPLASTLDPGDVLYRERPGPAGIHLLTLGNSIRVNLRVGEGDQMAMKAVIPIEYDYCNQEALLRRKRELLLAANAMMEGGAMGSLSRLQVEMFCSQHLIDVMIGANEDYFSIEMSFPYGRQGRRGGNLESALQIMHALLQHHRIEPDALARAKDKLRRDRDVYAQDLQAYGTADLVSAMSEGKLTYHNLDMAAIGESKLENIQATLDGIFKRGAVELSMSGAFDLQAAKSLLLQYIGTVQLPESTAPAPDRYQLWRHYDTASDDAADKGARFTTVQDDAVGPASTGGSGSEASDAPASPEERHRLILVPDNQERAMVLVGGYAPNASGIMPDGTHMADIMHAELYATLATDRDVNNNVEKLVRTAKELWLHPAFPRAACALLQEILNNRSFTVLRAEKHLTYESNVDFVLYDVQFAGYFVISVHSSFDKSESILEETRNLVAELRAGIRPVTEHHLQRARDQVVARLRKDRTAHRHWVGELLGTQSRRVPLKSSLFCTEFERVLRRITLDDVHLMFGSNAFGFGEEHMWSRVVHTAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S8</accession>
    <name>A0A061D7S8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768784.1">
        <property type="nucleotide sequence ID" value="XM_012913330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7S8"/>
    <dbReference type="GeneID" id="24565139"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7136" checksum="D3F3A3AFC5591312" modified="2014-09-03" version="1">MDGTSDVRQWTDVDPATDFSVRRQPRQSHKPTLGTSHDIHYVGRPKTDQAKSLKSQVSDEGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U4</accession>
    <name>A0A061D7U4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767165.1">
        <property type="nucleotide sequence ID" value="XM_012911711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7U4"/>
    <dbReference type="GeneID" id="24563520"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201360"/>
    <dbReference type="OrthoDB" id="10301764at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28147" checksum="37A5C57D9E8A52AA" modified="2014-09-03" version="1">MIFDSLTEAPRNLKEGIDWLIALKEGDAVENVLAMGTAVHKFLADKPVGKMELPALENYKRISQKFLEQPELKGQPFVSKLLGRFKAPLSKRPGVLAKYFGNIIESDYQNVLQTRRAKPEVVAANVAQVLYGVEKFLNDIKDSKYYNQAYSGRATWEASCSKSPEACAQILVGIAPMLYTGLRSLKDATEIANKKKPNSKEEQRLGEILNAVGYTEPERQGKMGSVHLLKALSGVDEQVLAVLYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7V7</accession>
    <name>A0A061D7V7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">BBBOND_0306700</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as parasite development and invasion. Plays an essential role during ookinete invasion of the mosquito vector midgut by mediating the interaction of the ookinete with the midgut epithelium and, further, by binding to mammalian host plasminogen in the blood meal, whose conversion to active plasmin promotes the invasion process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:10165"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:10166"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="28">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="28">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Forms a complex at least composed of DegP, ENO and HSP70. Interacts with G-actin. Interacts (via the DKSLVK motif) with mammalian host PLG/plasminogen (present in the mosquito blood meal); the interaction occurs at the ookinete cell surface and is required for ookinete invasion of the mosquito midgut. Interacts with A.gambiae EBP; depending on the Plasmodium species, the interaction is either involved in ookinete invasion of the mosquito midgut (P.berghei) or is dispensable (P.falciparum).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768952.1">
        <property type="nucleotide sequence ID" value="XM_012913498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7V7"/>
    <dbReference type="SMR" id="A0A061D7V7"/>
    <dbReference type="STRING" id="5866.A0A061D7V7"/>
    <dbReference type="GeneID" id="24565307"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306700"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="19" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="21" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 28" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="14" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="30">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="29">
        <location>
            <begin position="149"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="26">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="26">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <begin position="379"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00046218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="CDR96766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="442" mass="47516" checksum="2E7F512A57A0BADA" modified="2014-09-03" version="1">MASITSIHAREILDSRGNPTVEVDLATADGLFRAACPSGASTGIYEALELRDGDKARYLGKGVLKAVNNVNTTIAAGVKGHDVRDQKGLDDLMVKKLDGSMNEWGHCKSNLGANAILVVSMAAARAAAESKKVPLYQHLAELAGKPTDNYILPVPCLNVINGGSHAGNSLAMQEFMILPVGAPSFREAIRMGCEVYHNLKKVINAKYGQDATNVGDEGGFAPNIKSAEEALDLLVESIKKAGFDGQVKIAMDVAASEFYVKESSSYNLGFKCEQPCMKSGPEMVAYYKELCQKYPIVSIEDPFDQDDWESYKMLTDEIGAAVQIVGDDLLVTNPKRIETALAKKACNALLLKVNQIGSVTEAIDACLLSHANSWGVMVSHRSGETEDTFIADLVVALGTGQIKTGAPCRSERNAKYNQLIRIEEQLGSRARYAGAAFRTCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D883</accession>
    <name>A0A061D883_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="6">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EIF6</name>
        <name evidence="7" type="ORF">BBBOND_0307950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <text evidence="6">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769077.1">
        <property type="nucleotide sequence ID" value="XM_012913623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D883"/>
    <dbReference type="STRING" id="5866.A0A061D883"/>
    <dbReference type="GeneID" id="24565432"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307950"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000006">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="249" mass="26919" checksum="FD10CFA80C18BDD2" modified="2014-09-03" version="1">MAIRTQYENSNEVGVFATLTNSYALVTLGSSCNFASVFEAELLPQIPVVHTTIGGTRVVGSVSVGNRKGLLVSSICTDTELRHLRNSLPDAVEIRRIDDRLSALGNVITCNDYVGLIHVDMDKETEEIVEDVLGIEVFRSSIAGNALIGSYCRFQNKGGLVHVKTTTDEMEELSQLLQIPLTSGTINRGSDVIGGGLIANDWVAFCGMSTTATEIATVERIFQLSRPTELDSSVTDSHTLRNALIDTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F5</accession>
    <name>A0A061D8F5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-BINDING CASSETTE TRANSPORTER, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0308890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769172.1">
        <property type="nucleotide sequence ID" value="XM_012913718.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8F5"/>
    <dbReference type="GeneID" id="24565527"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308890"/>
    <dbReference type="OMA" id="NCITEEL"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="843"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="911"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1130"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="133"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="522"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="911"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1248"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1466"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1476"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1561" mass="175266" checksum="1EE55F4D66E65CC6" modified="2014-09-03" version="1">MQRSTDKPRLSDNEITAAYNSESKDYVGREYPPSPKTYDDRGLLRFVFIGWAKSWVNYICTHFVTPETVHRLPKADQISYWQPILSKHISDGLLRLEKAESDAVLKNDASKRTTPYRSVLLRAILLTFWRRIVLTLLLMMLMSITTVGTVVLLKHLLKTLSQKDQVWGNIVGVVLSIVGVEVLSTFLDQHTNLYNMRLQNVMEVAISLTLFQHGLCHRKDYTNAMQRCAVREGCKGAVHSWPPVNDSCCEDPLVCPARRHKNNELPPSMYTFLFVDTYFIISLVDATVMLMRFACNMTLGMVLIYTQTGMSVLWPMLVIVGITLLMVLVEAVNGLNISHALQSKDERISKSSEIIGSMKLLEMMGIEDVGYEIMKNSRDDELSVLQTRLTFFSINRSLMRVIGTVVYLVVIIDFIRKLKIAPNDSSFDISAPITLLHIVSTIVGSFDHLLKSLKMVVEGVASMRRVERFIRECSPNFYATRPEAHSDTLENELTVHDPRGDSTMHYYTLVLFKNASFSWLASRQDALTPKDTDSFVLANITFELERGDVKIITGNQGCGKTSFIKAMLGEMSLVSGSMAVAPLSTGMPIFYTSQEVWLPSGSIRSIITFGYAFDEDIYRQVTCAVELESDFASWEDGDMRVISEKGYSLSGGQRVRLSLARALYAYLIFSKANERLVGDRCCFLVCLDEPFNGLDPAVAGTIFNNLFNKETGLLVRDDVAVVMAMSPVTISICTSLDILDNLVEIHVHNITGGQVSIMDFMGKQPPGGIKPHVGPYEDKISELENKGPYNSFATLRKSNLMDSKQYGFVKGIQTRRAEEDHEMHNSPGDVEAQNKKCLTGPAYGTYISAMGIWYSVAVSVLLTSGVALDKVFGVLVARWSDLVKRLENQEGDDILKANQIMSEHEETARKMGILATIFIILIFAGMFTAIFANIRASRRIHEYIMNSLFNKSSTEAKVKGSLATTVTFLSSDIYYIDEHIGRFIVATLFSLLSICVQFITICYSTPILSPIPIVIIIVLYFFVCKSYLMASKKLQWVMLEANNSINAVYGDVISGSEIYRSFRREQLCVDRVRDYSESFFGIKFLKIAVTSWAMLTCKLFISFMVLSAAFVPVLYAYVRGVELKVAQVGLGISYSLGINALLNTFIFNFSMLEKQMCSMVRFREYFLQTKIRLDAVDKKVEMVPCSSSLRENAEHMHKHLIELIQRRKHEFRQCMFRRYRSIISTLLYRPKFEFVDIGDYFAGEHMSLELDNVMVPEPAEEFNANKNYILKGVTASTRAGDVVGIVGRTGAGKSTLLSVLQNIASKREGSVLLDGRELNSIPRKVLRHIIGVLPQMPFVFKGWTLRRFLDPRMLHSDEEILHALECCGLLDMVKSLPGTDPLDAVLAHEDIRVQRGYYVIIPLIRLKRGLTSTRSDDGEGGVSGERPDGNVACFSMSQLRSLSFARLVLYRMTYRILLIDEPPSDNCAGHEDADQAGGSPSGAEASSDASVPIYDLVRMFFSHCTTFIVAHDKNVLRSCTSVWLMQSGTLVERCSTQEFMARGMPSTGVTDAECCSPLRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K9</accession>
    <name>A0A061D8K9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly(A) RNA polymerase protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769039.1">
        <property type="nucleotide sequence ID" value="XM_012913585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8K9"/>
    <dbReference type="STRING" id="5866.A0A061D8K9"/>
    <dbReference type="GeneID" id="24565394"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307570"/>
    <dbReference type="OMA" id="REKCKEW"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="137"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="525" mass="58524" checksum="604EB5DECB249BB1" modified="2014-09-03" version="1">MESVGDGGAEAPSVDAGAAADDGSLVANLSTEDYDRLSAFYGPELYSMVEDEKHREIVERNSAMREAVKGLGKVKLGARSKLDAPCEFINIPREKLRQDKDTSAKGANQKNLVTVLGLKKLYNALYTPRVPFRVKLDVELAKLLEWIAPSDEERAHKEKLCTYLAHVGDQLRRASTFADATGLSLPGGDIDVCIQTTEDELSTLKLLVYAMSKMDLLHSFECIFNAKVPVVKAIDKATGVKLDISIWQQNAMDTTQFIKDKCEQYKYMQPLILLIKLFLQLRNLNDTYIGGIGSYLLYCMVLSFLQLHVSSCSRSKDEENTLASLYVDFFYYWGFLRDYNQFATTVRGFGHVFPKSLLSSRDTALLACESPLETSVDIGKNAFNMGSARASFQNAFFVLMEKQNMSGDRGGGSGAHDRQDCILEALYDPSHPIFQHRSESTIKRTMHQSYDYQKLASPENSLKEVCEHLRRMADNAESAGTANRQKPLAASVSHKPDDGTAGDEQKSLPFYVIADAVTREFYSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8P4</accession>
    <name>A0A061D8P4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0302160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768498.1">
        <property type="nucleotide sequence ID" value="XM_012913044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8P4"/>
    <dbReference type="GeneID" id="24564853"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302160"/>
    <dbReference type="OrthoDB" id="397220at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39767">
        <property type="entry name" value="CALCIUM/CALMODULIN-BINDING MEMBRANE PROTEIN PCM4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39767:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="577" mass="63614" checksum="E00FACE59E199622" modified="2014-09-03" version="1">MKSASHILQVLAGRGSGSRSSTCASAVCDPSLHQQRFSCRDIEYLLELTPVSALLHSHAKVLVVESALPLYACLKAMSEYEQEFALVYDSCSLEFLGYFDELMFLHLLLSGDFSCISCSGGEYLRNHGKHTFCKVEEDCSARDALPCMLNQSPQRLCVWSHKRAAPMGFVTARCYLGYITKHLRGCRERGGRKLEDVLSSEECTPVTEDSSLREISEILLCQDETTVLGSDGCVIGILNRGMIVRYVLALLRNKVKDSSSLLEALPELLASKNGAILSIDCPSGGHRVLTVWDVLRHMLYQLYKNAMITALYICFLRLFCVVLCSGVRDVKVEEHEGRGKSAVVRGGVTIPLLTIARDEGEGSLIQFEGNSSYTLGVDSLGNFAISAGDQPMLVISNEQNISFHMDNLSVRSVDFGGDLVVEGVSQFKMIWRESFVDARGWNGTVSSCAGIPMLGGFKLFGRGWVQKTFIELPVHRELRIKASFHFLDQWAGESGYMKLNTSSSAPLEYVWTDIHAEHSTTGINICGGETPDSKFAVPIEVTIPHSSERFTIEFGSTLEGDAVQQSWGVSGLEIYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Y3</accession>
    <name>A0A061D8Y3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767525.1">
        <property type="nucleotide sequence ID" value="XM_012912071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Y3"/>
    <dbReference type="STRING" id="5866.A0A061D8Y3"/>
    <dbReference type="GeneID" id="24563880"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204970"/>
    <dbReference type="OMA" id="AHIGVEY"/>
    <dbReference type="OrthoDB" id="311468at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="22544" checksum="72F13D2FEED76149" modified="2014-09-03" version="1">MESTGDLYNRNFGGKLKLKRLKVKGIRPDKKIGSESKRDDSKEKPNDAKEITGTGRIVSSGNTIQGFETKFVEEVAVGDTIIVKHPISKDNEARTVQSIMSNRTLCIDDAYSTDLVTTSVYIISELYAAAMIIPAGKQKAGEDQTLPNGPDSIPENKMSFVTVREKSGMWSYKTTTKVVKAQMTAEERLNERIKHSRDKHCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z3</accession>
    <name>A0A061D8Z3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0105140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766391.1">
        <property type="nucleotide sequence ID" value="XM_012910937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Z3"/>
    <dbReference type="STRING" id="5866.A0A061D8Z3"/>
    <dbReference type="GeneID" id="24562746"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105140"/>
    <dbReference type="OMA" id="GRQNECK"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002469">
        <property type="entry name" value="Cell division control protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="9">
        <location>
            <begin position="453"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="855" mass="96001" checksum="FFE8E2B9436D2924" modified="2014-09-03" version="1">MDSVSSNKTPLHNRESLSYHSGASYDRGAASMRRRLTLDESEHLTGTRRHTQYTQYGKTPNVLRRIRAARSDIGDMGRELFMQPDEIRRLPYILDARIDEVHSRFSAFLREFRIEDFDGLIAPTDEDYELLDKRENFASQWTMVYYGLKMMLYIDSHFGSTTGEELNNSSSIGRRFEINLSHIKAFDGVLYELLIKYPADSVSELDRMLQRFFEEMISEYFSETGVVVDNKQVQWNPRVRLYGKTEPDRASNLGPGDIDTLVSIKGIVVRCSDVIPEMTMAAFTCSGQLKMGINSFEQCTQEVYEYVIQGEVNEPTSCSKCKNRNCFELRHNLCCFASKQLIKLIETSQTASESPQSVIVYAYDDLIDAAMPGDKVEVTGIFKASSLRINPRMRTSSAIYRTFMNALHIRLEESSKYRMASAPKLLTAIDKNPLNYSQDIVNEIIRLSKCANIYDLLVKSFAPSIQGRDDVKRGLLCQLFGASVDPSSRMRSQINVLLCGDPSTSKSQLLKYVHMLAPCGVYTSGKGSSQVGLTAYVRKDVETHEYVLESGAVVLSDGGICCIDEFDKMDDFAKAILHEVMEQQTVTVAKAGIVATLNARSAILASANPVNSRYDKRKAVVDNINLAPSLFSRFDLIYLVLDCIDPMEDKVIAKRLCNSFVGIDQEPPPIDPVTLSRYIWFARANCNPYLTAESRQIIISEYLKMRLTEGSSKLPCASARQLEGLIRLSQALAKMKLSPHVTADDAREAARLMRATTFQSLIDPVSGKIDFDQLATGLTSAAARKAEVLCEEILSTIAFITTSEPSASLDAIYERCRLQFKTKGEYLERRQVLDAIDKLLGEEKLTKHLGGLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D904</accession>
    <name>A0A061D904_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SRP54-type protein, GTPase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0309310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769214.1">
        <property type="nucleotide sequence ID" value="XM_012913760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D904"/>
    <dbReference type="STRING" id="5866.A0A061D904"/>
    <dbReference type="GeneID" id="24565569"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309310"/>
    <dbReference type="OMA" id="DNEPLMA"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="570" mass="61864" checksum="A3FA5828E0D3F292" modified="2014-09-03" version="1">MIDYACVVSRGGVVLWNQHFDHGFDGHDGQRTGEALNKLISSVLLEERGATQQASIDGISFRWKALHSIDAVMYIMYQGIQSSQNIGNLLDTAADLFVSHVRKRHTNPSSINWVTDTLGFEFDEEFSQLLYKIGLSASKAAAPEATDNAPQRAANGKKEQSKKPGKTGRDWGIRQTVSQREMDALDYSTDKDSRSGQKPTTAESAATPQPEGAIDPSAKGGIGGIFRSARRSLGRIFGRNKSDLASRPSTDEGSNGPSVLDNFAKMVLKYAGNMVLTPEAIEEPLKELRLKLNAKNVANDISTMICDSISAGLVGKKTASLKSVAATVREALEASVRRILTPKEPINLLRNVSEANARGEVYSVLFLGVNGVGKSTSLAKVTYLLKCNGFKVLLIACDTFRSGAVEQLKIHADKLGVELFERGYGKDPSAICREGMKHARANGFNVVLIDTAGRMQDNEPLMAALSKLIHVNNPDLLLFVGEALVGNDAVDQLRKFNQAIHRMGESSDELRGRRIDGIILTKFDTVDDKVGAALSMCYITGQPIVFVGTGQTYTNLNKLEINDVVKSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9D0</accession>
    <name>A0A061D9D0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767720.1">
        <property type="nucleotide sequence ID" value="XM_012912266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9D0"/>
    <dbReference type="GeneID" id="24564075"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206920"/>
    <dbReference type="OMA" id="KAMYERG"/>
    <dbReference type="OrthoDB" id="10454314at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="186" mass="20603" checksum="F992FAE97D7B4571" modified="2014-09-03" version="1">MVKRYFKVPWHGPDARAVDVLTLVCQPMLTSLLAIAASLNVMVFMQMYTRCFLGFFVLISYGSCASATLSFVAFALTIIYGRYGLGLLAMLLYQSFFVQHVVLSIEILRQHALESKLDATALLGIRLVAGIFLGVICVLSLRMLMVGSALLDALLHGGVLWDLDGYEKKQEQKYPRAFSITVPEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9J4</accession>
    <name>A0A061D9J4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766576.1">
        <property type="nucleotide sequence ID" value="XM_012911122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9J4"/>
    <dbReference type="GeneID" id="24562931"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106990"/>
    <dbReference type="OMA" id="GSPFRWM"/>
    <dbReference type="OrthoDB" id="360291at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="356" mass="39937" checksum="F809DE344B85FF6B" modified="2014-09-03" version="1">MESGRSARKTTVSATAEPQQPEHEGNAENGSEASQDPTAGIKELDGWKADRADIPGPWRIFYPLSLKDTVGLYPNVNIRPSVLFCDITGAVTGPEHPDSGKGSFLLDAGDSVDIDDGESFVHNRKFATVLLSGKNFSNIRLVLLGRMFYSKTYVLNELKGVVRMRSAMFVGQAFVESYVCATAKQHMPSQRNPSVTEALHRIKRRITVVGATAARRIRSQLDRQGNEVDPLTWELQPLNAPGSPFRWMHGTDKWKLLGPCTAYRVLGPGVHIPHKPMIYDKYRMADLYNMVDPLKLNKTPYTALEKIEEETRRVIDAVFEPTDKPMNEFRVTDRDYLNQLYEEVSGQHARTSSHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K4</accession>
    <name>A0A061D9K4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769404.1">
        <property type="nucleotide sequence ID" value="XM_012913950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9K4"/>
    <dbReference type="GeneID" id="24565759"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311210"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="136" mass="15815" checksum="D832A6D3D2771415" modified="2014-09-03" version="1">MPANWVPTSEMVICRTACGAYLRFRLNRMPKTRQYHRLYSISRYAYISPPGGLLNESGHRGIPTHRSPSLSLPFPYALPQHALIFQRNSHRYLSTKRVIRHIASERSPRGLRHKPPDFWSMMLPTLIPSRVCNTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K9</accession>
    <name>A0A061D9K9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0311260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The helicase domain is involved in the stimulation of RELA transcriptional activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769409.1">
        <property type="nucleotide sequence ID" value="XM_012913955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9K9"/>
    <dbReference type="STRING" id="5866.A0A061D9K9"/>
    <dbReference type="GeneID" id="24565764"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311260"/>
    <dbReference type="OMA" id="KRQQVKF"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 10 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="12">
        <location>
            <begin position="74"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="290"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="467"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR97223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="709" mass="77626" checksum="0E8EE2C4BAEE4EFA" modified="2014-09-03" version="1">MPFSEFGVDPDLNRACLDLGWVLPTPIQAEAIPAILGGRDVCAAAETGSGKTAAFALPCLQLVHETLRERASGKRRPQAVVDDANDEQASTAAVESESATADDNLLTVDGDSEMQFDATTNTFLTNADKWFGARLCKPVGGTGRYCFECRVESDGLCRFGWATANCQYAIGLDKNSYGFGSTGKKSNSGKFLDYGAPYGRGDVLQCLLDMKSGEVAFKLNQRHLGVAYKIRSPGEPFFPSVCAKKAKFTVNVHKMTFPEEGYTPVGLAESSGGSGSSNDSEGRRAQRALCLVVEPTIELARQTLENFKLYAKYLTAPAITVSDNAGAHIVVTTLRSASKVPTGTVQFLVLDEADELIKQDAKATSQIVRSMRSRGPGPDKGRLQVLLFSATLHSPVVAENVEQLTREAQWIDLKGHPQIADTVDVCAVQLNPECTYDFERQYPEPPLDGLEHLDRASRRIKTLKPKCLVALLDKLNVSSGLIFCRTNLDCENLCTYLAHLNSTRSNTLINRYSATQLGGKLDQHRRKRNLEDFKNGLYRFLVCTDVAARGVDIAGMPFCAMLNVSECKFQFLHRVGRVGRSQARGLAIVIASTAPERVWYHTCTGRTQGGGAKSRFKAASVCRNYDTVDRGGCTTIQDEPAYMAEVHKLVPPGREIGTIDPNVLQLPPLGGTQYGEATMSMQHTEFQGPMQELYRASQRRYLVNIHRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA10</accession>
    <name>A0A061DA10_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0312560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769539.1">
        <property type="nucleotide sequence ID" value="XM_012914085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA10"/>
    <dbReference type="STRING" id="5866.A0A061DA10"/>
    <dbReference type="GeneID" id="24565894"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312560"/>
    <dbReference type="OMA" id="VRGNMDY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="227" mass="24835" checksum="2BB8F673ABBF7AA9" modified="2014-09-03" version="1">MSTGGSDLGELIMVVGDLHVPQRALDLPQCFRELLNTDKIKQVLCTGNVGSQKMVDLLLGISPNLHMVKGDFDDDPKLPEELIVNIGMFDHYVSYRSSGNFKIGLINGYQLPSWGDKEAVYEYAKRMGVDVLVYGHTHISDVSKVSGKILVNPGSATGAFQPWAPNSIPTFMLMAIQGQKIVVYVYEEHEGQANVVMSEVDQDQDDVTPSNAQLSAKALLSSKKVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA84</accession>
    <name>A0A061DA84_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767975.1">
        <property type="nucleotide sequence ID" value="XM_012912521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA84"/>
    <dbReference type="GeneID" id="24564330"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209420"/>
    <dbReference type="OrthoDB" id="10599320at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="158" mass="17030" checksum="B715C090188B5BB8" modified="2014-09-03" version="1">MGCCMSAPMEKVEADSRKPHHPPHSTVSEPLPDPKELEAILSGYDAISVYEGVGKGVCPMEGVESGGCPMKRAMLADAKKECIGKCPYSAVEDAPAAPKPDDLPAIAVEMESHFEDAKDPLEITDKDQLEISDKDSTVLPEESIPPQDNFELYDATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA94</accession>
    <name>A0A061DA94_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769654.1">
        <property type="nucleotide sequence ID" value="XM_012914200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA94"/>
    <dbReference type="STRING" id="5866.A0A061DA94"/>
    <dbReference type="GeneID" id="24566009"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313700"/>
    <dbReference type="OMA" id="NTKCFAR"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37613" checksum="DD949602DA12950B" modified="2014-09-03" version="1">MLVSPYLTIRTGHGLTSVCYFGSRLVTGSRNGGLCSWDLESGNRLSSSRPRADLVSVLPLVPHGIVLSSSCSPHCGIVALQHKDVVSLFDLKRSGVVHEFAMCHSTFARIRCCYSGMPLLLCPSGLNSIVCHDLRAPYEIKGSYNATYSNHGPQKSISSQHVIEVRAPAVGEDVGSLQNFEPLPSVSDHHVAATYESGLVAVLDLRNPAIPVSTLKLKGVEALPSLAAWRDVLLVGDTDGNVSLLHASLSDGLMLLRSKNLYEYDTLLRGVGCLRTRADGAISLACCWDYGIRVLDTHTLEVSAALNAHHDTILDAAFDVVTGDFATCGLDGNAHIWKLFRSSYEGVDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA2</accession>
    <name>A0A061DAA2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor, arginine/serine-rich 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769827.1">
        <property type="nucleotide sequence ID" value="XM_012914373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA2"/>
    <dbReference type="STRING" id="5866.A0A061DAA2"/>
    <dbReference type="GeneID" id="24566182"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401330"/>
    <dbReference type="OMA" id="GTIANVW"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001074">
        <property type="entry name" value="Splicing factor, arginine/serine-rich 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="122" mass="13834" checksum="9449C9BBEE3616B3" modified="2014-09-03" version="1">MGSRYESSEGKKVYIGNLNPEATVDDVESLFSKFGTIANVWVARRPPGFAFVTFEDSRDASDAIDELDGTEFKGQNLKVELSKGPRPRHRRDRSRGRDPYSSRRSPRQAHQVPQPQLREGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAH7</accession>
    <name>A0A061DAH7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769168.1">
        <property type="nucleotide sequence ID" value="XM_012913714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAH7"/>
    <dbReference type="STRING" id="5866.A0A061DAH7"/>
    <dbReference type="GeneID" id="24565523"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308850"/>
    <dbReference type="OrthoDB" id="367168at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="524" mass="58190" checksum="55FA6237E341D11D" modified="2014-09-03" version="1">MWIDRPRKVQRNAQIENIDNIPQGFFDPASPPPSTWPEDTNTHIISDQCQTPTWPDALDIVNVEDSKHDTIDFIIPEHPDMGSIQQARELSAPEIGIEVASKWSPAPDFKPKDLSLVIHHVDRLGSLELPPIPPEVLVERADIDTTKDEDDPNNFDLRIHVPKPTLQDSIHDVDFDYEPPPPSNLQPLDPIGPSTPAIDLNIEPFDAAPHSITEDFDQKTIKQPDIELCLAPWATSKPAHDSTATPETELFPAEAPRTFRDMLQWLAGLKNQKHHGTLRQCVVKAFGVPHSDPSQLAIFINHAKITPTDLFDILQLTAMFAGSVLFAIAPNWKANVSSSTVKPKSSDQSEEPDCCALLCQLRDYAYACHYQLQFLKSQCNRDKLSGGWQDCHYGSDITSPNSPLQAFLTDGWDSTFKTHPFDPCNFCLKSRIRMGFRDGDLPSSQQTGATLSTILTPSCGGDDPLLTLCSYLNCLTRRTPRTTGELVSFFHHFGIELNGYASESLSSLGNSLSTPYVNCVHLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP5</accession>
    <name>A0A061DAP5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769942.1">
        <property type="nucleotide sequence ID" value="XM_012914488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP5"/>
    <dbReference type="GeneID" id="24566297"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402440"/>
    <dbReference type="OMA" id="ADWSCFY"/>
    <dbReference type="OrthoDB" id="365067at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="138" mass="15722" checksum="657D053F1E95A7BC" modified="2014-09-03" version="1">MGRRASFAHMFTQVPKRTHLVIATIVVGIMTNYMGRKTIRKMQNANLAANMEKYRGDPPNWSCFYHAKQYREECSDYNILMGGDYIERICTNLEAKMRDCQKMLAKEIEGCRPYAMDAAIEVDNSQPWLVKSTGSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP7</accession>
    <name>A0A061DAP7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766971.1">
        <property type="nucleotide sequence ID" value="XM_012911517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP7"/>
    <dbReference type="GeneID" id="24563326"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110820"/>
    <dbReference type="OrthoDB" id="365966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="194" mass="22327" checksum="D252FCF5DEE2C76B" modified="2014-09-03" version="1">MKTATRCPDGSKCDLVNKYERRHLHLGTFDGLDRKPLVITVHKSNLNEPRYYAITADSERATGNEWMSIGVLNEEEHKEVKGHHQNYYRKILTKQFMKRITLTGQRAHGIRAQAFISRNVRRTPEDVMFRGCDKDDIDPEFMIPPPEGPEYSKGTIIIYPDAMEGKYYVDFAYGNPFGGPKMVCFKEVIVKVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAT3</accession>
    <name>A0A061DAT3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exportin-5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768215.1">
        <property type="nucleotide sequence ID" value="XM_012912761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564570"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211710"/>
    <dbReference type="OMA" id="NTIMEAH"/>
    <dbReference type="OrthoDB" id="360399at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="2">
        <location>
            <begin position="720"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1388" mass="154988" checksum="AB62FC581E58C52B" modified="2014-09-03" version="1">MFREEVVAAVFAAHEGSYVATQRLQQLVECRDDPADPAMALELQRQLALAYDALISLTQISHNSRDEAVLAFVSTKGAAATRENYIECVDLLRFYGFTLLVKFVENHWHRLPDELRRRCKGDMERLFSCGRGEPTVAAEYNALAAPKVSQYVATIAIREWPVSWHEFIPLCLQSLNARFASLGGKANECKQTLAELCIFGGLLSEISVDITDCMDNKVLYKKRTQILGLFQNHICEIFLMIHRVIVLGMLNGQPQILQMVISIFRNLSGIMDGFVFVEFDVDDFLRANIDVTNRSDVIQTLHNICTNVVRKPLKNMPKSPDFDLSNDAYKLKLNRFVRNLVSVGESMQLDCSLETACDQLQLTQAIKVLFERNGVYVLTNLDVDSLKLLVEYLQGHLVMHPSMQIATCAVTALNGMLRRVGALGEARLCGEYHSGVFVPNPCVRWLDHRRMLLVLFVRCLKMGNTALSENAEHPSSSSTIDEFIAESVGTYHVRSQRWSKLLFAYVPIDDEFCVGQLKNFEPRFAALRSAILNCVSLLCTVSHDYMNACIKALADIFTTAQRVVMDAPCVHAASICTIQNISEKRLQWTCKKLVLFDGTCFMFEAALSRLRGATIDVTTTVDNTKTPEWMQPAAANSVLQAAQAKAGGNMVDTWISTGLTYLLHMLGLQLPSVHGAQLEVRRLGMLSSSAILLLYNSEPTERILEYVVGLLLVQGAGDGHVTKVHRSALVTLISLCKSCSGLVSAYVEPIVQRIRQCLNVAEDESARDLLLESLVALTSCLQNFETQRRLTNEIIAPYVDDIAALATKVSSVKLEERPAMLFAFLYGSGPNPASASGSPAREATDEESLDRRRRNLRRVFTMSLSIIRCCVVPNSPEERSKANHAERVPVRHPLEDRLLDIFVSTCTILRALSGMWRPGFRTQDDWRKVVLSPGEEEWISLQGFNEAIATEESLRRLVESVFSIPSTMDAKLVRKCRRHDFLLRQSALKLCGEIFSTAITFKIDLVPHAEAVVMEALVEPLEWISMSHLAQYLKFALVPSKLSLRNVLSKVISTISERINAEWKALNRLQRNLLAGDEGAAANRSAESRILHLYYLRVYASIETGLQLMALVATAFRIRCLHALENESEAGSDEVVMMGTPGSEQVSVVFGSRELLTCILQCLCSALCWPHCRCVTEALRLLRTYAKIAPTMDSYSVSIAESFASEVLLVLHKQLRIERTFDPLNLGNDEGHGSTTTAYKRFWSNTRDGSTNYIKEFVNTMSTFYECLVKCQPGVTGVLNQGEINVQALLRFSSVVEAVKLLTPYLQEHECLNFLTKIISHNSVESRALLQAGIEANVLDQNARANAKMLQFTASILETRSAMEIERSGSGESDDEFLGSDIAYLLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB54</accession>
    <name>A0A061DB54_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0403990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770097.1">
        <property type="nucleotide sequence ID" value="XM_012914643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB54"/>
    <dbReference type="STRING" id="5866.A0A061DB54"/>
    <dbReference type="GeneID" id="24566452"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403990"/>
    <dbReference type="OMA" id="MSEDWIT"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="465"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="75163" checksum="A04A25996A9CB7E5" modified="2014-09-03" version="1" fragment="single">MLFITFKDLCRLEPHQKSRPYAITLPEDSENPNKNIIHNLCTSAGNLLGYRLPGTYDGSGFVYGNASRLCDAILAFLYAVFSDVHDNQPYVAGRSVLYDDVIVEIKSQLWRGHKGFHHVIPKVATGLQRYNSAVKASNEKVKKPIETVLGYVKPDGELCSGIQALQISETSTSTQDERTVESAASLVEDCKEFARVFSKSLTAATNAIDDLNPKLKRKLENARRSFFNHVDWLSRWSKKGEKKRLDKMIQKIKSRLKQLANAVKDKIKQEVHTVVELLKDRVSDIKMKLEGITASLEKYVKELGQWMGEAKKYIQDVKKFVDDIMKQLDGEHRKAIDEAVADIDSELGKKVGELNKWIKDAEAAVNVAKQKAENVFKRLDKDSGTTIGQGIDKITTANEKVRQVDTQLELVHKDLGDWKTAAQGVISKAAGKAGEVSDKLDPNKKDAGHPIGKNLENIETAGKAINVANESLREQAEKLKEWITEADDLRQKAQDKAQEVYDNLKVHEQLSEKIRDIQTANEEIKNVNNGLNSVEKNLEDWNKEAGKVIQEVVDRVKEVHKKLNHGDDQQLISQGIKQIKEAKDKVDAVSRHLNTANDDLKKWREAAEIVLDLAVKRAENVHKALDPTKDKSTLGDQIHSIDTARQGLVDANMELEIQVKSLNKWIQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB6</accession>
    <name>A0A061DBB6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770177.1">
        <property type="nucleotide sequence ID" value="XM_012914723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB6"/>
    <dbReference type="GeneID" id="24566532"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404770"/>
    <dbReference type="OMA" id="YYPTSEM"/>
    <dbReference type="OrthoDB" id="389832at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="230" mass="27164" checksum="3B1287E6B4FCAC88" modified="2014-09-03" version="1">MALNITRALRICRISPLVGFKPGAGVVYHPSVEEALENDNRRLKRAIQKGYELPKIEGERMYHGLDSAKTVENNWESLRTVRYPMNGGYDRFSYRLPQVHAFNEDELAKFFDSTDYQKKFTLSEIWMSGKHRITCLLTIYIGFIAPFIFVWAEGVWRNHREPIEPAIPVEDYFKHFVWHQVGPQINHHAYQQYCEARRTNKWRNPHINPEDYIPPEFRNLQSFEGVKLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF7</accession>
    <name>A0A061DBF7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770054.1">
        <property type="nucleotide sequence ID" value="XM_012914600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF7"/>
    <dbReference type="GeneID" id="24566409"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403560"/>
    <dbReference type="OMA" id="IMKSYAI"/>
    <dbReference type="OrthoDB" id="436833at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="405" mass="46436" checksum="44618A9BD02BFA3F" modified="2014-09-03" version="1">MERLSHFEDLLNYCLDNRDTLGKRDIIASLSYMRSLRNFSLSSPLLREYGDFVCSNLPIFGGALHLVVHRFAVIGYTPALVRIYEDHLKSSLDDLSVKQLCLIGWSYAKSNVYFQELFDRIAEAYFYRDDRGSLTDVALLLWSFAKVERRVPHEIGALRGVVLGTLQSLLSALRDPNCDLDETARLYMDKDRMFYSNVTHDLCMSAKALAVLVPRDRDTVKLLVEQLLELSRLGKLTLTAQGITSMWEALCLTGLSEPSVVDELCEASRYLRLDHSFNSNMLSAILSSIRTLRVRDPRIVYQIAHWLEKRAVQMHAPQMYSAICNLDALRIYHEKAWKQLGTWSVVEADSFVGVVVQKKGIDLELSDIRHIYNIFKSNDRGNDRIYGILEHFMSCKEDIERYGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBG3</accession>
    <name>A0A061DBG3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0403660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770064.1">
        <property type="nucleotide sequence ID" value="XM_012914610.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBG3"/>
    <dbReference type="GeneID" id="24566419"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403660"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="898"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="847"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1408"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1694" mass="189602" checksum="65C7C6DE6FF616DA" modified="2014-09-03" version="1">MAAHGVKLETLKDCLQFLEWLKGRKWSALRNQLSGRLKRLLDKKYENVNQQQIEGALSIFLGHVSTFHNKLCKTAAKSAIQRITAKDALEAVLQCIPKLLSVIYFLQYHVDKRFAKVGGGDWANDMVGSLAMYVRFGPDYLKRMISNAGPIDKYLIATADTNAYGVIPGGFDPGELKELARDGYNQGSLMTGDLVNIFDKEKNPNNLFRDVFVTSAVSKNSAVEISNVANALRLVEDFCGIFEKVKGEDDFKSNLQARYHCISWLELKRHCSKIKRSLGSIFKGNRFSFNGYARPYDKLKTEDIATKMAKWLKNNLDAIRGKLKITSHKLDVKTFVTTNLIPYGFTFNGYNVGTGKNDYKALKKDWDAVIGELKKANEGLDKLKQILGGNQCSNGKKDKQPKRIPETNPEAKPEPEPEPRPEPEPEPGIASDSEPGIASDSDDDDETWGEDLEFVDEALGDEDAAPISPQKEAPPVKVPDAPKEVVSEQKVVKPTATKSEATKPATLKAEATPNQGKKAEGGQNQGKKAEGAPDQPTQNNGQSELKPLISPGGDNASPSSAEPLQPSSVASPDPKCSNGKPPIYLGFDSGKTKYCPRDGKTWDISERKKLHEKWDEQKQSYEFKLEQKQKEIEERLKRQKEAENLKMEVEERIKEDERQLQREAMLPRIDVVYRPQELSENLDVAYNTAAQRHLNRFVSPMPFDIIKPTNLDAVIDDSHGTPTTDINEPAMGGSSGIEVKDLDGAPVQNTDQLSKQNQDYYSTVDTIGSPYVEGDEIPDPFFSDKRQTEIDKEIETSQKNMDSKLRYRYYQGLGDAQNKWKKSLVDTEQAEKEERKRQIDARIQNVIERVRERNERKNKAAQNLDKKFEKTTENIWKTQLQQNLDYIEENVEDEDAKKRVQQKRLRQQKQLDQQNVSHDSPTSTVSALPSQPGNPAPAPSSQNTGGRDGHRRIPFVPREEDLMQRGDDVIYPDVVYSDPVDPFAKYGYGLGEMYTSFDGQPVVDKRREKEEKLLREKNKNDAKKRWVESHQRLYAQTHANSGFSGTPTGDSKGLAEAMPFHDNASVGIPMGMVLKPKKPAIAFPPLPQKKFGPGTPAVPQGIDLTKNKRPTKLPSVTTPNDTTYVTGEIDIIPIQHSTDISGAPIKDVTNKIPIAKVQDTLDYKLLLPDQPTGYPITNSNQDTPVQQPPPKFKPSDVSGSITSGFISDVESWRKKEIMYNNIKRDLEAHKKALANDQERRIKEAQRYGEGFKKMVHMHDDDRNQHLLDDVQESTEKLKLPSPRKLQDIVYPNDKPYVAPPVIDTLPHGLQSTEATGDVSKTFIDVKDSESLAEVGLSVDVLKQSPFQPLNDYDYGRTFMPPPVVAGGQLASTLDSPRLVSERSIPLFANPHLCTNPWSVSTSTSSTDTPPPPASPPPLTDHLPPPKTVREMLYWFVGLSQYGLIGVVTEHVYSLLRELNKDTSHPTDAIEVTGDPTTLTASNVTTKLTEACLYSATVIYKVRHNNDFKAFSTFDFKSVYSQFRYSSDPACLLCQLRDYAYACHYQLEFLKAQCNRVESHGGWQNCKYGSDTKTSSPLQAFLTDGWDSDFDTHLFDPCNLCLKSRIRMGFKRGDLPEKSQTGGTISTILSPSCGGSDPLLTLSSYLNCITRRTPRTTGELVSYFHYFGNSVYKALSQLPPISPSLILRLPTHQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBV8</accession>
    <name>A0A061DBV8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770249.1">
        <property type="nucleotide sequence ID" value="XM_012914795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBV8"/>
    <dbReference type="STRING" id="5866.A0A061DBV8"/>
    <dbReference type="GeneID" id="24566604"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405470"/>
    <dbReference type="OrthoDB" id="514167at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019265">
        <property type="entry name" value="RTRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15924">
        <property type="entry name" value="CLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10036">
        <property type="entry name" value="RLL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="240" mass="27061" checksum="0E94097A1C31B3A4" modified="2014-09-03" version="1">MSRERLIRRRLRALGVTPPQELNAHFQALVLKLEEEHIRHYAISERRALKDADSKAFVKALLKYCDDVGVEIDDSMLVDGKLTEEGITSVLDGLTLAALEEEYTDLVSGEPATRIPHNLQTRNCMFQQLGAARIAVMTVSPLYKTRSTTSWSYSAYRRCNQTHPCRKFGNENATKLNTVHMNLADVPCGIRSDNAVVTKAARVLRTLHSQELCKLQADIVWLSERFQELTANPVANCHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA8</accession>
    <name>A0A061DCA8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Merozoite surface glycoprotein gp45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767626.1">
        <property type="nucleotide sequence ID" value="XM_012912172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCA8"/>
    <dbReference type="GeneID" id="24563981"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205980"/>
    <dbReference type="OrthoDB" id="10658736at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596212" description="Merozoite surface glycoprotein gp45" evidence="2">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39605" checksum="F29084F438B466FA" modified="2014-09-03" version="1">MLLTKFYFVALWFSIAQVVGASPGEDGETAPAPRADAQQSAVGARTLREEFIILRDFIEAWDIDLTEIQEPQVLAAKTDLESLAKKTVNELFTFIVNIYTHQEIFTEKTEQDASVPNYKGVDRYRFLKAIVYSMGKKFMALDAYLKKESTKKMADDIKRQMIKLNFAKRMEFRKITSLQRISKLVDDSYESEEAPIKKLLQLFVAVDAALKDLGTPDADPFASAYVESSGVGEELQEVDKVALAEAVERSYELVPQQENLDALIIDLGPSATGDQATAARTTTQSAVEEGTSGHLPQPAGSQGPRSDDAERGVPETGVTGSGPDSATSSLRQEGEVQTTTKPSSAFCSFVTATLFVSIAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE0</accession>
    <name>A0A061DCE0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769928.1">
        <property type="nucleotide sequence ID" value="XM_012914474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE0"/>
    <dbReference type="GeneID" id="24566283"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402310"/>
    <dbReference type="OMA" id="QLNHKNN"/>
    <dbReference type="OrthoDB" id="367072at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="372"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="507"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="822" mass="98777" checksum="2A5788C0A2A91866" modified="2014-09-03" version="1">MVGFSVFAAGDPGDGNTFNCGPYRPRPISLYAGKANEINKFKDIEVLYHRAAQLQSPLKKIAEAVPKSEDPPEKKEALQHLCNEFSNGLEGIINATKDYAERGRMLREARQIIIELKSGSPTIMRSNELNKAMKLLDQSFECKYRLLSDIHQNDMYEYVSRLLDIQQLVNTHKVPEPSAKEGGIMEGKVNDAPNAKPPFYYGSALDRKRTDPQYLSDTLNIIRADLNKIDVILRDPLMEDKGSVDAVNNILSYFHKFEVKAQDFVKFVSQCLKKFGAETRLFKRMDTIINQLNALDVNSHKAIPYLKRYKRVESKINELLVLKETIVLDDLQREVSQILNKLLQLHYLNHENHKNNQHYLNHENHKNNQHYLNQLNHKNKQLNHKNNQHYLNQLNHKNKQLNHKNNQLNHKNNQHYLNQLNHKNNQHYLNHENHKNNQHYLNHENHKNNQLNHKNNQHYLNQLNHKNKQLNHKNNQLNHKNNQHYLNQLNHKNNQHYLNQLNHQHYLNQLNHKNNQLNHKNNQLNHKNNQHYLNQLNHKNNQHYLNQLNHKNNQHYLNQLNHKNNQLNHKNNQHYLNQLNHKNNQHYLNHENHKNNQHYLNQLNHKNNQHYLNQLNHKNNQLNHKNNQLNHKNNQHYLNQLNHKNNQLNHKNNQLNHKNNQLNHKNNQHYLNQLNHKNNQLNHKNNQHYLNQLNHKNNQHYLNHENHKNNQHYLNQLNHKNKQLNHKNNQLNHKNNQHYLNHENHKNNQHYLNHENHKNNQLNHKNNQLNHKNNQHYLNHENHKNNQLNHKNNQHSNQSKHVYQHWMRRHVNRLNKKAAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF5</accession>
    <name>A0A061DCF5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768865.1">
        <property type="nucleotide sequence ID" value="XM_012913411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF5"/>
    <dbReference type="GeneID" id="24565220"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305830"/>
    <dbReference type="OrthoDB" id="365709at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="62620" checksum="1272493D05CF2350" modified="2014-09-03" version="1">MAESECCQRRSAALSNMLEWYYRDPVGRTYGPVNSFKLVYLIYSNFFEEDTPFASCQGGRITAADFDPLRKLLPTLQNDFMEYNEDVFACQHYMDSMLHAPDDAVDSEIREVEVLPPSVPTKQYTVQFVERTDTIVDVDDHHMLHRSSDSDISATEPAGDQVFDEVPMAEPSPRETHAELERQYSRVTIPSLEDYRRQQPPVAAYHQDYTFGYNGQLNTSRHDLHSDIAIPVRLDTGAYMDAYHGVTSSTAPFRRGRTGAPVLDVTREPVERHLTANYGRTTDAFDMSGSGYTVPNLHEDDRETAALGSMPTSVILPSTAAPSEEPTQQRIVKRTTKSYPIIDEGMSNGISHKAEEAADTPAGIAEYGMSQLSPIGIPPPNIKNWLSGDDTPYIPLGALGQLPTEDHSSALAGKSSRHDPVAERSAGSKDQRLHAGRSAHLSMSLASVDAGTQTRGASESRLAQSWWREDSATHHDASYNAHIPRPPGVFPSTSHSASMYNDGSNVPKTESLMPAHHMLIKQRLQSNLRETQAHLSRIPSRKISHVLSQSHGKLFMDRSLLEDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCH1</accession>
    <name>A0A061DCH1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769973.1">
        <property type="nucleotide sequence ID" value="XM_012914519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCH1"/>
    <dbReference type="STRING" id="5866.A0A061DCH1"/>
    <dbReference type="GeneID" id="24566328"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402750"/>
    <dbReference type="OMA" id="PHTECKE"/>
    <dbReference type="OrthoDB" id="363356at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="28433" checksum="9CE7D237205F21E3" modified="2014-09-03" version="1">MGKIDSAAKKLRVVFLHGFTQTDEMLRQKTYAFKTTCSHYLDIKYVCSPHVLRTPPAFHDDARTGKDDDEIREMENAAREAYVRDHGTKDSYGNTWFFTGSHGEYSSQVKSAEVVGLEDSFKVVFDACKEHNADGIMGFSLGALMTALAAQRALQDESVGWKPKFAVLFSPPMVGNQTICNILESGPKIDVPSLHLISENDTIVKPERSYRILKYFREPEVRFHSAAHTVPHTECKEVYRNFFTRFLSHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCI9</accession>
    <name>A0A061DCI9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767786.1">
        <property type="nucleotide sequence ID" value="XM_012912332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCI9"/>
    <dbReference type="GeneID" id="24564141"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207550"/>
    <dbReference type="OMA" id="KPIFCLI"/>
    <dbReference type="OrthoDB" id="364699at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="60600" checksum="CB609EBAAE6A613F" modified="2014-09-03" version="1">MEATDADSSSPREESRRVWPCSCSFLDGLCRRYGISGRKLKSYSLFSLLLKSETLYLLYTCYVGLLAASHPHADPSHPVKCGTWLPLFWLLKPLIAAVADSVDTIMQYTSGFYGWVLSCVDSNAPRGARKRGFLDALTEFHRRSNLVLVLSQLGVVILMPAIMVYAYLHPLGEGCGPSLVAVLSLCQIAAAAVSEGAFCRYAQCNDEMNEVQFSSLRLLFMTGYGVWNMLSIVMPYPRTSDFWASFLALVNVLPCFLVGNGLCILWVLLCDPGGYEEAVDMSKRAETKWSPKVTVAFVTMMVMALSVRYPYDCLVLRPAEYPSLTLVTLLALSVAVKVLVSCLLWRFVDLDGMITIAKFAFLWSMVLMCGGHRIMPVPTGQSSLWYASLVAALVTALQQVLFTFGLVLSIRTAPRGLEATITSLTDLCVDIVAFMFKGQLSLRPLALKLLRHEAAVDVAVAFFCLYNFFVLFGKPQVAALKRRFEFEPLESARDVLPLPLPVTGFPSANEALTSQSHIDIESSIVAAHEAMKGADVDKSPWADESELSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN9</accession>
    <name>A0A061DCN9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770098.1">
        <property type="nucleotide sequence ID" value="XM_012914644.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCN9"/>
    <dbReference type="GeneID" id="24566453"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404000"/>
    <dbReference type="OrthoDB" id="366915at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1598"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1671" mass="183232" checksum="DF114231A0C6D363" modified="2014-09-03" version="1">MSGHGIPLNNLKACFQFLEWFKGDTAMQGKVAVELATRMSPYYSTTTLGSQLPAPFSAFLKNVSTFYNKLVTHASAGDYGSKSAKNVIDAIFECMPKLLAALYFLWYNVDYKFEAVGGGKWRYLYVGWESTRRTWWGTYPASGGALQKYLRSLGSADIDVIPGGFGHDEVTCGYDYPNYGYKFGENMISELEKILKKARGVQNDFRDTFLISVLSGAGTHQVNTANVLRLVRTFCQVVVDDKYELDGGELKNALEKGLKPPKSCINWGELKEHCSKLYNKFNTFFKDDAFSYTGQAPSVTSVNQSNFAIRTAQWFRDNLQTVRSNVKQISIHYPKDRSTWLTHLQPFANKYIFPCGFTFGNTGYGTFGSAWETLPPKWRSVLEMLVSNDGGLAKLKQLLDGEPCSPAPRPPHPPPITSPQASSSHVPSTSVDQGSGGQQKQVYHMVLTGRAGENARGAGPSVAASSHPRQVQSSQQPGPPGVGRPSGPPGPQPSPVAKTPVSEPVSTQTDANANHNNGQSEIKSEIAPDAASSASALDGGAKGDAAPAGPKGEPRAPGPNGPGSRGPTQNADTRASPAKPIDQRTRQVTQGTSLAPSLPSIPEPTAHPGPAGDSDQSSPHSVPQSPQTVLSTNPKSTQPSNVQSPDSSSPGDRGTGSGRKPADKAGSSVAGQTSDKGRQSGGDTDTTTSSAPDPGSNGGAAGVGSGGPKKEPGNPKKDLDAERKKRWNAYGLEQQAKRTIDEEKMKSLIQSVNSNLHTIRQGVQEEALRKAVQENMLRKTRIRQNADPNKVNASTCSNYSSMHIGRSICHTNSTMPMPTTTSSHYLTPDVLEKIKIAEEQERTKQDEQRKRQETNDRHLRALHQGIEIETEILKQHAEQPTYPHADRLISEMNERNTKRDALGTVIPIHPGMEAVKLDGKATPSSKGIPRSTFPPISSNIDVPIGYSMKHKAPQWHDPPPPSKPILQMFRAIPQGIVLNDNHQHRKSASGSRTTVEAPLLSQALEIDPSEIVLNVSGEALKNSTNDDTDLFPAPLTLDATPVPDHMQYKRSVDIYEPAVVKHDVPLTDILPKKRPPPVPAVPKNPFHTRTPFYSELHKPPDSITLFPGDPPSVTQDDMACTPPWMLSQRGVSKPGRADEMPHMPNDSHSRFLHTDVLPRTVREMLYWLAGLRHSAVYDTLEKYISDLVGNYAKQTKSLSSDIETMELAAVPKCIVGNEVTQALRLSCQYSIIVLMGIQGFHDPHTAYKNDNYSKAPQYEYSTDPACLLCQLRDYVYACHHQLQFLKAQCKRGKSHGGWQDCKYGSDITASNSPLQAFLTDGWDSTFETHLFDPCNLCLKSRIRMGFKRGDLPEKSENGITLSNILTPSCGGSDPLLTLSSYLNCITRRTPRTTGELVSYFHHFGNSLHDAFDGRLLQLGTALFTPHADCPDWDHLGLPDLEAVKGIGGHESLFTIQGSKHDHPRTLSTLVGCGSDSSNCPQHCSPITYRAYALYSQSFAHTYLSWTVYLPERLRESLQKLHYDLQKHLGSGKCSSLHSCSTALPLLYTHGFTPPEVGSPPPLQCSDVIAKLQDIVNGNPIATLMTSMDDFLYRVREPFIFTIVALWSLAFLIFANTMLYRLDVLRIRSHLTRSSRSHVIDVKALLTDGTKMPSLYDIDYFDEDVLSQFVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCP4</accession>
    <name>A0A061DCP4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0307030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768985.1">
        <property type="nucleotide sequence ID" value="XM_012913531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCP4"/>
    <dbReference type="STRING" id="5866.A0A061DCP4"/>
    <dbReference type="GeneID" id="24565340"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307030"/>
    <dbReference type="OMA" id="HISTYET"/>
    <dbReference type="OrthoDB" id="365124at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="250" mass="28598" checksum="2957023D70D842EA" modified="2014-09-03" version="1">MQSEYWGPPLICLFILVVYYGVRFYLNKKRLQLVPWMIYGLEGNGPHVVSFVLTHPNDEAYYFSPTLEMLGDFRQQYSSVDVHALVLSKGNYSGEGDSRVSEMQTICNKYKMQCTILDEPDMQMDTPTWDKDRIAELVQKFLEKNSSKVVITFDEHGVNSDSHRISAHDAVMAVKEKISDLRVWMLASFGSASANFPLFAYLEAIFAKTIACVHSFGPVYQNVKIHESESSSGFKLFFNSYGYVNIFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR9</accession>
    <name>A0A061DCR9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNB-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0208840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767916.1">
        <property type="nucleotide sequence ID" value="XM_012912462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR9"/>
    <dbReference type="STRING" id="5866.A0A061DCR9"/>
    <dbReference type="GeneID" id="24564271"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208840"/>
    <dbReference type="OMA" id="DLYTHRM"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="399"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115091" checksum="FCFB97DE0A33D37F" modified="2014-09-03" version="1">MALAALPARVALSAYTRFLSFAQYRHRCVDAIATHRCWKTDARVAGDYPKVKRREGKKQSSDAKAETAPRRRSVAVPPKPPKHISQPKTAAIAYETYWEESSIQELEAKHPELVVRGTVVIPAFATNEAKVARHATRTDNAGGSDLNSDPPSTENDSAVSGSAKRQRIDRSPLCDEDGGHAAVTESQDSSPSVTREGTAAEAGSDDTGTSQTADTADVRIFGFIARNRAFHGDEVVAVRQRRLRQQPATHDDTQLMEQQCRVVRIVKRSPALESFVGVMDANACLNATDATFKCQPQDTRWPAFNVRRDQMDSEMLEQVQQLREKGKIFCLMQFNEWHEHDMEPSGRVVRIIGSTADPSARMHATMIFHGLNPSGFSDEVLDNLKELIKSGEGMKEANRVDKRDITVFTIDPQDAKDLDDALSVETVRDEKGNYRYKVGVHIADVSHYVKEGSAVDMDARQRATSVYLEHKVFPMLPQMLSENMCSLLPHSEKLCFSVFAELSEDPSDGEMVGNNLYIRNQEFILTRIISCERLSYQTAKEIIDSEMRNRAGATDANLASMPIAQFEKRYIEDKLVNDTSVVSADAAITDDPAKGNCHGESSQEVPEASATPNSLMNINRHVFKPLMTLYFISRKLRHFRLKQRGAVMVDTNGSCKCHIPRVGEKTERLWVEQIPRESHELVEEMMLLANTQAAQLLAKSFDNYFLRVHENTSRAIKQLVVSVMPQDLKSVLNPEILPIPELLRKCAKHMEPTAFQSLSFAALQQFKEAVYSPVNKDCTTAQGVTGHWGLALPMYLHFTSPIRRYSDLYTHRMLKTVIDGTYTEQSLKVLDDICKQCNLQKRKAFDVQKEYKNFAFNQYLQWACTSEGSAPPYAAGDSMFAKAFPPDGNDIWGMLYDHACVFSIVINGATTEDAKNKTSIIFYIPLLNEQRSVSCDSLSVTPLEAVVCGETVSLEGTQNTGDSESMVDGYFKEVQNAGTKRKADDARVESLTVLKGGSKVRMAQYDKVQVVLVPGSAMWTVRLSRDEPCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY0</accession>
    <name>A0A061DCY0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0209580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767991.1">
        <property type="nucleotide sequence ID" value="XM_012912537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCY0"/>
    <dbReference type="STRING" id="5866.A0A061DCY0"/>
    <dbReference type="GeneID" id="24564346"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209580"/>
    <dbReference type="OMA" id="EWKNECF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="643"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="823"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="876"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="957" mass="108592" checksum="7E67D69CB3EA2831" modified="2014-09-03" version="1">MAAATENTLNVGDVVMVYGVRGTVQHVGPREYVNKGDGDVLHQIIAVKTDKPLRVTTNPEEQLKCGGDEYVACVPAGSVKHYNEQEAAATRIQAFFRRAMCRIKYVREAAFLFWDHMENLQEQRTLASKRDVYIPILNHIKSKHEQAAAADQTNAPQKRFSNGFEEIKCQNYQETSYNGPKLGKQVTTKFANELLDAYKSGQVTKLPIDYAQRILVDMLNWYRSNDKGAVNHVEVPSHENGNLIVVGDLHGQLNDFLWILYKFGPPSSRNVYVFNGDIADRGMNATNIFLLLFAFKLADPGSVIINRGNHESEDMNEAYGFAREVRQKYDGHIYNLFQRIFWELPLTIVIEKRIIVIHGGLFRYDGVTLDVINKVNRKRMCPASPDTFDDSIVFDMLWSDPQDKEGRSASTRGADCIRFGPDVTAAFLDLNKLEVCIRSHQVPSTLKGIETSHNGRCVTLFSASNYCQTTGNTGAILIFTKGLHFEVKEYMSPSLEAINTLANNTNTVTNKVIDAALSVEMEKETQYLTRHTSEKMLNDILLKIADIVCENKQALWLHCYKYDTAKNGMVDPQPWTDGLSELVGIKIPRLFSIWLLKALDKNTGKVPYNDVLKRFHIGYEPVGHSHKNIERECIAHIFDTMIKSDLSLKEILMVFDRNLDGVVSYAELDEAIRKLNVGLSNPQIKILMRTILSSCIDNEGGRADIVEFLSKLKVIYSASTRYKVKEDWMEAALPAIGRVILSDRTEAAARYYNPNYDPSAAAAGASRDETSRRRSSAIRAVALFQKFQDYDKIGGGLLSYSDFAEAIKKLDLSKAEQELGFKITDQHLFEIAHMIDVTNTNKINYLEFLQAFYVVDQNKYSVVNEMWDHICSTLYKHRSSLRHAFHSYDAAHNGSVYIHEFKEVLYAMYETLGYTEAPFTFEQTEILVECIDTNDEGMIMYNEFLESFHPQYTISTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD28</accession>
    <name>A0A061DD28_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768081.1">
        <property type="nucleotide sequence ID" value="XM_012912627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD28"/>
    <dbReference type="GeneID" id="24564436"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210480"/>
    <dbReference type="OrthoDB" id="10401938at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="302" mass="33612" checksum="CC39AF5806E55A23" modified="2014-09-03" version="1">MAYTSLTEAPHNLKEAVDWLVALKGTDAEKNLAALGEAVHKFLVKRPVGYTEIPALEAVKLITKEFLEKPRLQGLWYVKDMLEKFNGNMDKTHDVWLKRQTANYHSDYENIIQTAGIERTDMIKNVTDIVDAYEKLLEGVKIPSLYKSAYTSEATWDASCAKDPRECALVLVGIAPMLYAGLRSVWDSARTAIENGPESYAERALGDVLKAVGYDGHGCRGTVSSSAIRDSTGDVYPYVLDKVYDIAGFWAFYGQANTQAAEPVKTRKFYMANREVYGIPGVDVDMGLVNAWNYKKGKKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE3</accession>
    <name>A0A061DDE3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ENGULFMENT AND CELL MOTILITY 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768396.1">
        <property type="nucleotide sequence ID" value="XM_012912942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDE3"/>
    <dbReference type="GeneID" id="24564751"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301150"/>
    <dbReference type="OMA" id="SINVTSW"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="125"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="322" mass="36903" checksum="38A7FF98761DB7B7" modified="2014-09-03" version="1">MDVQRHLRSIFQRLLSCLIKTSCAERILLNYGFLDHLWALISAPSGLECSICNPEAIIAFEGQYGELLASLSIDSLVDTLAVQLEIGVKYRKYLEDALLQIFKKNRDVRRLDFLAGIKVDQSNAEHCLLLHESWAALDDRPMPESFGVTKSIGKEDDNLSSWGDLGFQAPLTDFRMTGVLGLQSLHFVATRHKKRAREILHLSRSLQAWFPFALTSINVTAWVLEDFRHNKLGPFSYHNDLQAVELFYMLHTYYFFSFVNYWRKHATSIFDFKSISVEFRKEIGEETFAIIRRIISDKSLGETRYYGSTLLNAIGETFLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF4</accession>
    <name>A0A061DDF4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein mrp homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768416.1">
        <property type="nucleotide sequence ID" value="XM_012912962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDF4"/>
    <dbReference type="STRING" id="5866.A0A061DDF4"/>
    <dbReference type="GeneID" id="24564771"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301340"/>
    <dbReference type="OMA" id="SIHICTE"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="206" mass="22178" checksum="8A2D94C94F0200B1" modified="2014-09-03" version="1">MYWKVRDIIAVHGCKGGVGKSTVAAGLALSLKNHGCTVGICDLDICGPNLAYILGADDSYVKWRRVELEDGAIKYDSHVPTTSIQAQKVSNAAENVRVSHDNDGFPTMAFERVEPITTSLLEPKVVHGIKLMSFAFIKSKQELGYAAFRGPVLDQIASELLLKTDWGELDYLILDLPPGTGDVIISILEEVTLSGLVAVSTPHGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH7</accession>
    <name>A0A061DDH7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769600.1">
        <property type="nucleotide sequence ID" value="XM_012914146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH7"/>
    <dbReference type="STRING" id="5866.A0A061DDH7"/>
    <dbReference type="GeneID" id="24565955"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313170"/>
    <dbReference type="OMA" id="NIKDYGN"/>
    <dbReference type="OrthoDB" id="430577at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="115" mass="13332" checksum="1B5FB39536777B14" modified="2014-09-03" version="1">MASSEALTRILKWRGVFQAAKWPQLGNEVAEGPGSKYTNFSLQHIMDKYNFLPTLYTQREFLLSLGHKNPEIVQDAFLKNEQFNYYVRTDRPEPRGETPEALRFQEDAHHGSGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP5</accession>
    <name>A0A061DDP5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769775.1">
        <property type="nucleotide sequence ID" value="XM_012914321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP5"/>
    <dbReference type="STRING" id="5866.A0A061DDP5"/>
    <dbReference type="GeneID" id="24566130"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400810"/>
    <dbReference type="OMA" id="VLSHWIG"/>
    <dbReference type="OrthoDB" id="360930at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52103" checksum="D4942FE8584CAEB3" modified="2014-09-03" version="1">MYSRRSEEITRISQRLAGIHIPVFCVLESHMGDPVLSHWIGADGVVAGTALGRVSAYLFDNSAPRIAKSSTTVDAKDDGGSNSKLDQSSSKPSETAQESSTSAHGDDSKSDATLPSATNAAVGGVESPETSPANPDGTVAIHVAEDECDVDKGDDSCGCDSRKFPNLASLFGTVMNYIRCGKSGADPVRLDDVLPGRYTVFASFSDEPIRAVFIHRRQLYCLIGTSLISVYDVDKYALLNEYRLSLSRNAGYKQIAFAACKILVDCMRGSTILDPVAKRQTSSTHRVYPSNVLDFNGTEMMCYYRNVNKYFVQVLTLDRYVSKKVLFSISMPKSVFLVTHGRFWGSDKLVVVTDMLTISVYKYHEVTVPIAKRRSRVDIVALCGGFSDFLAVLMKDSTIKLLHGHTLETFFRIPLYPATFELGWPYTLINYGDIMSFTSDEGVYCLRLPSKVIAVASEWKDNGSSVDHDIHGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU0</accession>
    <name>A0A061DDU0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768756.1">
        <property type="nucleotide sequence ID" value="XM_012913302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDU0"/>
    <dbReference type="STRING" id="5866.A0A061DDU0"/>
    <dbReference type="GeneID" id="24565111"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304730"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="217" mass="24584" checksum="EC0F10588BBE0B36" modified="2014-09-03" version="1">MSKLAVDTLNEAIEAILTQSKEKKRNFVETVELQISLKDYDTQRDKRFSGSVVLQNIPRQRLRVCVFGDQVHCDQAKSLGIDYIDLEGLKKFNRNKTLVKKLANKYGAFLASQTLLPQIPRFLGPGLNKAGKFPTQLTHNDNMEDKVREIKASVKFQLKKVLCMGVAVGNVEMTHEQLRANIVLAINYLVSLLKKNWHNVRGLTIKSTMGKPQKIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDW3</accession>
    <name>A0A061DDW3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768816.1">
        <property type="nucleotide sequence ID" value="XM_012913362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDW3"/>
    <dbReference type="GeneID" id="24565171"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305330"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="201" mass="21784" checksum="23538488E1DA9146" modified="2014-09-03" version="1">MTGMDWMKCICGMGCRMGIGCYCCTWCCEKCKSSSGCNGCKAHYMVRIKNRGKKYECELSRCKKQCEGKEKDCKCDCCVKKCTEQPDSCKNPVLPPLQPSSASASESSSSREHSLPSTGEQQPAVLPVTAARSGDLGSDGDGHSITVSPDPSTSPQAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKVPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDZ8</accession>
    <name>A0A061DDZ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0306290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768911.1">
        <property type="nucleotide sequence ID" value="XM_012913457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDZ8"/>
    <dbReference type="STRING" id="5866.A0A061DDZ8"/>
    <dbReference type="GeneID" id="24565266"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306290"/>
    <dbReference type="OMA" id="EWIINSY"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="121" mass="13913" checksum="5EDDEFBFCB2A2B76" modified="2014-09-03" version="1">METELKAYLTLLLSYVILGLYFVWALTPEWIINSYGITYYPSKHWAVALPSSLLILGFYFLLYNFFTERSMLPPLNSPSAFTGIARPHINVHAQQVLRIREKQKIPLHDVPLGSVNQLLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE21</accession>
    <name>A0A061DE21_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEL-1-LIKE PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768956.1">
        <property type="nucleotide sequence ID" value="XM_012913502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE21"/>
    <dbReference type="STRING" id="5866.A0A061DE21"/>
    <dbReference type="GeneID" id="24565311"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306740"/>
    <dbReference type="OMA" id="YFIDGYK"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596259" evidence="2">
        <location>
            <begin position="29"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="616" mass="67907" checksum="39BE273C39E02528" modified="2014-09-03" version="1">MRSAGAAVAVLLAAALPLLTVGPQKVAARGWNPDDDRIKRFNEAMTTRYGVIPHEGNPAAAFDKFKELADGPVDAVTVQCWYEMGKIRLFGYDSFYFWRKRDAAEARDLFKKAADRNHAPAQFYLSFVYTFNDTGSFGRDAQKAIAYLKRAAALNYVPAILAVAYRLLYGIGCAKDVKAATALYKKASRLSRRSTDALTYMTPSDDFVLDERSVEAFKRAASVTLQSEEKQKKEAMRYWESKAAEGDGLAMYEMGKLLENEPAAESTVAQLYRQASDNGVVAATRDLGVCYMNGIGVPQNAEKAVQYLTAAAEQGDHEASKYLGYLYYTGVERPQEGKPVKRNDELAARHFAEAAKHEVPEALYFMGEILSKRGKAVVGIRPQHKLAKALAMYRAAADHGLTHALSREAEMLERGSGAKPNPTRVAMIYKSLAEGPFTSTTITDSFYAYVDGDYLSAFLFNALAAFAGVQVAQLNLGHLFVSGRGLKHLDGARSVAKSALSQCFLQGDPRALRLLGTIAEREGQLKVAAELYSKGFKGGDIECLDPLANILASQRATWRKAIALLEHKQYRRARNTDGTPPGVHRTLDGVRTWWRIKALRAKRAIAKYTTRDADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE30</accession>
    <name>A0A061DE30_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0404070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770105.1">
        <property type="nucleotide sequence ID" value="XM_012914651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE30"/>
    <dbReference type="STRING" id="5866.A0A061DE30"/>
    <dbReference type="GeneID" id="24566460"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404070"/>
    <dbReference type="OrthoDB" id="364549at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="147"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="30050" checksum="2D2C34DEC79563DA" modified="2014-09-03" version="1">MVTSIYKVRRRLCSYANGNDYSLSTFAAFQFAMVLSDCILVSCCHPPGALDCLGQSLQFRSMCHHQLLTRGFATTFLSVRCMKTDLCAFRKGLIDTAITLRAHLGRHTLPATKQGVRFSGFASHHQHPDKMGNYFDDAPYEDSDVTIFDRIVNGSIPSQKVYEDDKVCWCHLRFICVQILAFRDINPVAPVHILVVPKVRGCLSRLSRATAEDTEILGHMMVKVAEIVRDNDVGDFRLVVNNGPQAGQQVYHLHMHIIGGRELSWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE44</accession>
    <name>A0A061DE44_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768991.1">
        <property type="nucleotide sequence ID" value="XM_012913537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE44"/>
    <dbReference type="STRING" id="5866.A0A061DE44"/>
    <dbReference type="GeneID" id="24565346"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307090"/>
    <dbReference type="OMA" id="PSPRVGC"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="491" mass="55092" checksum="FDE58FB8EC936770" modified="2014-09-03" version="1">MPKNKTEAKAKLAAAKREAQERKARKKLLKGTKEKDISQIIKRFRYSHDTADKGKLVDVEGVRPGPRASATFTPMQNDIAILFGGEFYDGIQVEVYNDTFFYNASKHEWRMLQTTAKPPPRCSHQATVFNNYLYIFGGEYTTLDQFHHFNDMHRLCLKTLKWEPVEVTGTVPAPRSGHRMVTWNGYWVLFGGFHDTTREATYYNDLYLFSFKTSEWKRVCQQRYSGAIPEPRAACLMLAPRNSNKVLVFGGFTKTKDTAKNVAGKYHQDSWLINMDLALQGDALVWEKISTKGKPTYSIGFGVANHQNVGLVVGGVSDTDSGGTSLKSVFYNSVYTLNVDQKRWYPLTAGDNASNPDKPDAEATLEEKMSSVSLAANPPPRMNPHAVVCGNTLYVYGGIVEQGSVEVTMSDMWVLDLGKRDGWRCIDPGFNFSEVYKGEMDMQEDSSSDEEPSNSAEDDDDEEEDGDEEDDSDDEEMLTDEDGSDQDADNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE76</accession>
    <name>A0A061DE76_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0307990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769081.1">
        <property type="nucleotide sequence ID" value="XM_012913627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE76"/>
    <dbReference type="GeneID" id="24565436"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307990"/>
    <dbReference type="OMA" id="NVGIYHD"/>
    <dbReference type="OrthoDB" id="364122at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="27899" checksum="EEB70C33DFB668D4" modified="2014-09-03" version="1">MQSLDRYLGIALSGSYLSYCLIVKDVLRKAGSISLRCSSLQHPSRIAEAFKMLRGSMSPAETPGSTSPACFVGMRGDNVTPRSDLAARRAYNRCRVRTIVECQSDAIFGNKPVIFKERELYSTIGRLSRIMHAHLMAGRITNEKIMGTSCLVTCARKRFTSLLSVDAAQFSGIAVAWATAVCLKRRMEIESMKLDESFMQSVESRVRRDRIVVELAEMLEKNKDAAAAADLQEALRSRISSLVDKHLDKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEI5</accession>
    <name>A0A061DEI5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769526.1">
        <property type="nucleotide sequence ID" value="XM_012914072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEI5"/>
    <dbReference type="GeneID" id="24565881"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312430"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="373" mass="41057" checksum="675587AFE64F83FB" modified="2014-09-03" version="1">MVYNSLTEAPHNLKEGIDWLIAVKGTAAKSNLAAMGAAVHKFLVDKPVGHTVVPALEVVKLNVKDFMDQNELKNMPYVKELRSRYSSPVRKYGTPFFIHRADESIYKNIVKTRKMRPDIITNKVTDVVYGCEKFLNTIKVDNKYESAYSSEATWEKSCSEKPEDCAAVFVGIAPMLCAGLRSLRIASDSGSLSCLGKSKTNVGNILSALGYNDPKCIYNSNASYVYNALKNLRLRMFLTLYDLSGFWAFYGSNKIEAVREKPVDPVIPEAEPSVDGEGEQSVIPEAEPSVDGEGEQSVIPEVEPSVDGEGEQSVIPEVEPSVEPVQPEVDDVEQPVKVAKAADVVKSAKKAARKVSKKALQNEEKQQRAFSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEJ4</accession>
    <name>A0A061DEJ4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769571.1">
        <property type="nucleotide sequence ID" value="XM_012914117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEJ4"/>
    <dbReference type="GeneID" id="24565926"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312880"/>
    <dbReference type="OMA" id="MVICMAG"/>
    <dbReference type="OrthoDB" id="363571at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="355" mass="40213" checksum="7DD3B34892DD0111" modified="2014-09-03" version="1">MAEIPYAAAEVLRLLRESHTRRLVANLTEERLLRRSRKSKTIQTGRDAYGKLLGRLFEAGYFQQFGIDDERLLEMLQERDLIDDAMIHVAHGLNLPSHLGSAAFFLIFGWITCQMKLSDIDLYDIITCYSLAPSDDGRLAQIIRHLVLTVIDLIVLKLQAEGCREKFDRDLQFFLQNGTASGIYGRLHTLMQCGTMMYEGSADAIIANTIAIELPCMSRSRQIALTRVLRHVTDNILGRANRNHFGISQRGSAHLWRLIVKGIEESGVTDLAYDDNALLLSIRALGNQFDISVISRVLSQDIYSHYNDRNDYHRNVDLGGALFAMHKHGIAFEFPDTFPLAEGNIATVIMDRRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DER3</accession>
    <name>A0A061DER3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769916.1">
        <property type="nucleotide sequence ID" value="XM_012914462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566271"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402200"/>
    <dbReference type="OMA" id="EWNCLIK"/>
    <dbReference type="OrthoDB" id="362011at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1409"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1564"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1714"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1409"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1738"/>
            <end position="1749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1806" mass="197562" checksum="2C92C46E8903C1EB" modified="2014-09-03" version="1">MTHGFQPLSSSGATLYIPGQLELIDTGVSSASDSDTCEQEAIAATPRASAVREQVDKSCRATPSTASRVRRTPKASPVRVALRRYAVTKSETLQHLYEHWTPLLTRAWPQDVQGAANVLAECNSLIGIQRRWLSNYECALLFRQLATDAYPDPERLRCVLGLLLRWWFCGKFAVHLAQFPHLGNEAVLVNAAYGILSSSWTQARLMLQLLECHDTLGELLYGVLIHPTEAQSGDHAIDAASCNSLLLKVLPIIKRGLLEPDPEPACSKATRFIEDMSTKALYLRFDRGFDNKRLHLRHECRTDDKLSLVEKLWGGVLRCNVANLQSGQPQRCDCHGRMAGILLNLISKTTSLGTHGSSSTLEGCRQLSTRRLIGYFAKWVAAKTPKANKNGAVVPPQESSEGQTEDKFVATGMAGNCARQKPGEASSSSCDNRATSNCCTLNRSAQLLLDTELAADSLQRVDECVGLCAGVVFSKPPLIKEEPGVDEARTTGAPIALNTSDTFIVMAFGNIWDNRNSSADPVHRACMTLLAGAILMIEDNHLMGDVILDEGYSRPLLASKLSQSDDGRVIVDKVLRHRQFYSWSSGVANGKYNGCSEPSAAATSRAERLKSPVDSAARVDYIMGEPSQHLGEVHRALCEAAGVCSNNASFVPALMIRDAWTSSTRHNVVFKMCRQAAYHVLDGLWQVLQQGETCSANISLEVGDGDCRRSATAYAMVALASLMGDTVVLQTADAHVGIVRIAVLLGRGKDFASPDYGSHITDDNLLNLLLKLLYTDIATDASMALECHSSQLAIYRTLLVHYLRKALLQPTKQAFDIGFAGKRVVDFDAIFRRILRLIFFRVHVALVDRPKFESFLRTRVEYAAQHDNTDNEGEFLEEINCGYIELSDDDTGRKTSSDGDVGVDGAIDHRIFGFLEYSPSHRVARKLWRRFVKSEHGGEQEEMPSHSGPLDRSMAREAGAANSEHPRFSKGMPDMDLLFFESVFELCGQLRFCVDEDQLFRHNKVDRLLYQLFLHICHVDKGANIQRNYETNVLCKINRVHETDEYGEVDTDRATLDSLGWKQGSVGMPSGGSTACEQPADEQKECGYVNLDVLFLSRQKFTKRSYYVLSRLAIESLVRWLSPESAACAVCRWASSVPIDTTSRVKAYKPATASAIVTMLSLSMLCHVALPSAEELPLQKVESLVSAANVCFVNLTVSFTAAATIPDAVEVIGSDEDEGSERGDSCAISRGGGAHVEPTGDHIKVKEEPNETCGAASTGSGVEPAARVKRERPSVSDDLCRHSVNQHSCDERHLIASTDEHYVAPELAEGAWQRGRSYVPGGLQMWKDHKIREHRARQLCLMRLRNHLRKRLIKEGVHLLQICVVFVHILGHVVLQTANCLLNPQNGYVTASHTAATLQECSSSEKQGCFGDSNNTDVSEAPPVGTTTAPVIKEGVTACPSDIPSSSLTSFTTAEDGWVTPPSGNRDSSATSPGNATSKSRSEAHNANGEGQQGNGGVRDGREAIEAPHRHELVSNADGEPVNAEGVTQPVIDAEGVRCVPGAYRDPARSGSCRMKDYAESDTTCHKHNSDASMAESKQTCGETRGEHSCQRNEDTNAVDYPNNLGTKDSHQMRLSADPKLASKFECAMQFLGLACNTLDSLLGACSTVSRCCVGDDLEVAIWDNDRMIKAAEEELELLLHEISFLRDQVEAHIAPLRALHSEAMLTADYPSTQDSGAGRHLKAEHKAAQSGDDESCVESGDSSSDGDCSGAEYDDDLGSFVDFETDSHLGMVTFRRPNKRANTASRLRDVVLRSEWNCLIKSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES7</accession>
    <name>A0A061DES7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769986.1">
        <property type="nucleotide sequence ID" value="XM_012914532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES7"/>
    <dbReference type="GeneID" id="24566341"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402880"/>
    <dbReference type="OrthoDB" id="367072at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="383" mass="45073" checksum="7546BB481150B7CB" modified="2014-09-03" version="1">MDEITKFKNIEVIYHRAAQLQSPLKKIAEAILKSEDPPEKKAALQNLCNEFSNGLEGIINATKDYAERGRMLREARQIIIELKSGSPTIMRSNELNKAMKLLDQSFECKHRLLSDIHQNDVFEYVFRLLDIEQFVNTHKVPEPSAKEGEIMAGKVNDAPNDKPPFYYGNAPDRKRTDGQSLSDTLNIIRADLNKIDVILRDPLMEDKGSVDAVNNILSYFHKFEVKAPDFVKFVSQCLDKFSEETHLFKKRDTIINRLNALDVNSDKAIPYLQWYKEVESQIYELLTLKEIIVLEDLQREVSQVLHKLPHNHHYLYHENHDNNHHFLYHENHKNNHHYLNHENHKNNHHYLYNNRHSNQSKHVYQHWMRRHVNRLNKKAAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET8</accession>
    <name>A0A061DET8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proliferating-cell nucleolar protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0403430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770041.1">
        <property type="nucleotide sequence ID" value="XM_012914587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DET8"/>
    <dbReference type="STRING" id="5866.A0A061DET8"/>
    <dbReference type="GeneID" id="24566396"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403430"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="830" mass="91723" checksum="77ECDD2C87186A85" modified="2014-09-03" version="1">MTQEIVVQSADSGAGASLDMAQGDTAKAPGGRLGWRSRCREMQGVSRRKKADKQGAAGDQPRERVSYSDEIANNPEFERYYQDQRICPPEEWEAFMAACRRSIPISFRINTSAHLWRHTIRRLAALSRTHDDLCLTVGLSYTPEVPDLDPGTSLCYQLKPDKSSLRKNDKVTEFRRCLIDEDNRGAVMRQELVSMLPVIYLDPQPHENIVDLCAAPGMKFLQILDTVNTALQYRDRQPPCSNRGVIIGNDVCQHRVSTLSHHMKTVSCPSAAVTNFDGGWTQQTIHTFAASRFPYLHGASGEKLLFDRVLADVPCSCDGTTRKAPELWSTWKATSGLHMHRLQLSIVKRALQLLKPGGVMVYSTCSLNPLENEAIASYVASEGRREHGVELQPLQPLPNFKVSPGLTEWLVPNPDGGYFKSYDEVPAPLRPRVYASMFRSPEWGEEQARCVMRVLPHQNDTGGFFLFKVRKAHSAMPANHGERPQEIRPINVVMPQPRPSVALKRGAKLLHDYVRHCDVFPDMFDTICRFYGIDGDKRTAFGRVLVTKRYCQKNCFLVGAVDSAALFQKRKSQKAQQREGASSTRAESPVASGELQDVQEANAGQPEALDAVKDEHEETKSEAGSESVDNAEDAAQAATNTDNKCWEPCRYAQLGTRVLAKMTSKATLDSPCEMRISQEGCLAVLEFISRRVAFANAAFCADFKESMPVQELLKHEQLGNIQGLDSCRQSGKLESGGCVVIIVPAWGRARIPASGVSVTLADGVVVNRHKTPDAETAATDDRQTAASVSDIMDVIPLSCIISDMGTLLAYASPQVLKLLQSVASETNENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYG4</accession>
    <name>A0A061CYG4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765882.1">
        <property type="nucleotide sequence ID" value="XM_012910428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYG4"/>
    <dbReference type="GeneID" id="24562237"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100250"/>
    <dbReference type="OMA" id="DNRVPNH"/>
    <dbReference type="OrthoDB" id="366058at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595786" evidence="1">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="142" mass="16020" checksum="6632CDCADC3EB800" modified="2014-09-03" version="1">MQRPSWHSGSIRVLGGATLLLLYAASFLCSADSDGARGSLITEESDRFTVYSVSLSDVPVFVTADDFHVDLLGTQFAQITVDGCGVEWKIRLHQKIPFGLIFYPEFSVTLERLERTTSTWVVKVRIPKYYDLEPIPFSREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYQ3</accession>
    <name>A0A061CYQ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0100850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765942.1">
        <property type="nucleotide sequence ID" value="XM_012910488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYQ3"/>
    <dbReference type="STRING" id="5866.A0A061CYQ3"/>
    <dbReference type="GeneID" id="24562297"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100850"/>
    <dbReference type="OMA" id="RTFMWIG"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18560">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7_HMT1_ABCB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000221">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="63"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="386"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="669"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="736"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="797"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR93756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="846" mass="94082" checksum="0F0399008DD3AC09" modified="2014-09-03" version="1">MGKCPVTGHGKSMEDDDAFRVNVEEDVKRATAKDVIALMQPFYWPGNPGDSAHKVFMLRLFVILAIVSLFFGKACNLLAPYYMGQVITALGKGDKSLALKDLLLMAILFLGGTTFDETRNLLFSYVQCQGLTTLALKFYSHLHTMDYQWFVETKSGQMIRCMTRGLESMRELTRFGVLLMVPTMLEAVSVCVLFAVYFREVWLVVTLVVGLTLYIVVTILTTNWRNKTRAAEAQRDDEMHNVANDGMNNFETVKYYTNESHEVAQYTSVVRKHQRCQWLVLSSLSMLNMSQEVMKQATIGLCLLFGVLAASSGRMSIGDVVSIQTYLFYLYRPLYMLGTMYAMICRAMAGIQSAANMMQCKPAVVDREDAVTLDLDVTSSSDVPMIEFKDVSFSFPERRGTQPKVVLRNISFSVPKGHSLAIVGPTGTGKTTLSLLLCRLYDRTSGQILVNGMDVTAVTQESLRRNIGVVSQNTAMFHATLRDNIRYAKLDATDEEVYEALRRASFLDRVMAMPDRLDTVVGEKGMRLSGGEKQRVSIARCFLKDPPIIVLDEATSALDSKTESEIQSTLRLLFHNRTVLTIAHRLSTTVDCDCIMYMENGEVKELGSHGGTSPCGKPISKMSALHNLVQSDNHNGLERVLEGALRIRRRSDPYATVLLPDFVDKRDSHGRTALHLAAHKGRVACVRLLLRYGASAQANARDSTTALHFASQNGHHEVVRELLRAGARVNPKTSTAWMTPLHLALSKGYAELAAELIERGAVQKHNAKGKLPFDLATEPTLSRLQELLGTERFESLRDNVTDTPKEVKPPVPFYNRKKKQKAPPAEAKTDAKPDTSADAQDEANPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ26</accession>
    <name>A0A061CZ26_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0100320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765889.1">
        <property type="nucleotide sequence ID" value="XM_012910435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ26"/>
    <dbReference type="GeneID" id="24562244"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100320"/>
    <dbReference type="OMA" id="WINMAGI"/>
    <dbReference type="OrthoDB" id="365346at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR93703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127596" checksum="6CE1AFBCC4D72D05" modified="2014-09-03" version="1">MVSCDNCGEIIPDNGEGEVTCGTCGVVQQLYSQTVVEEFSASYSQTQKIGRLKASASQPEGRSGASGRGQDTRDFQYIVGIQMVLDNLCKMLVTSYGFSNQVEVEAKNLWARYLSLVVENDVPVSNMFCDPFTKGLKYNVDLHYLKRSFQIPPNFEAFKLPPRLHKVIRRMGQTSFEYATLLCFGVLEQQRKHDSDASRAEADRAMEPPASDAPAGDSRANKRRCATAYDYSDIKAFLEGTDMPSVLEDFFANEVELPRSRRCSPTGFPISILNAEVAQRQLPVMPWLPNVYLFLEPANPYRIAYMMEALYRHDFLWVVLHAYPNLEPIRGFERYLGMYGPVASADLPAAIESRPLELPVLCEVAMALRVPNVEGRVDSLSRNHRRLRMELINDIYVALMSKYFGKTRYTNMSAFNMSWIAPRMDLQLVCGILFAALVKCRYAVVVGDIVRWVIQGRIPLRSSASLLSSSILQAAFREDQVRAPRMRYAPSKQEEAAYNLFTNTNSPQSSFHLEITVSRLMACGVYGDGCSSAQGEPPARTLRYNVHGLCRRLVHHLRLPSNVLAVADLVINRVTQCSEEESAEDEPQGDDAIKGNIGRLLSVYGVRLGRFPSHVFAAACLLAACRMLWPVFHYNAPAYPRRAAPSESGGDNPASDPQPDPNDNLQETHVIRRERFPQTIEFDSTRMRWVVRISKPKEVCKAAGLPTESGPLKEQDLSPGQRQFLEQIMQSMRRPALVDAFGVPQAPSAPKAVSAITDKAGLSDLVPAEPPAADFLEPPDGISHHTSGTEFFFDARDRGYARAGTCALLWLLHHRPTEAVRALSEYHTACDTRLLRRIAADHALRVKSSLLTKNVIRLYLGAVNPVGRDERIASALRDVYYRNLWINMAGIWSGSVASCFGLREEDYTAPGAIDSDDDDEQEESSLALEIRRKVVAEDVERVQSLLLPCLEADEDMAKLKSALPRNHQVFYTVTELFSSYPYYSGWSPEKSLELENYRQLVSNQRDQVLGAVQEMLATQVIEEQNETWRQMSDALESELQLEGVSTMEWPDVLQEVDSAIPPELNLPGFEADYRRAMRSMLPQFQDMGTVTAAGAMLPHHPWRNYVSLKSKLLQAERQRVCRRCFRGLRTDAEVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZC5</accession>
    <name>A0A061CZC5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766162.1">
        <property type="nucleotide sequence ID" value="XM_012910708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZC5"/>
    <dbReference type="GeneID" id="24562517"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102980"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="10378" checksum="A0BE2E3CEC86EDAD" modified="2014-09-03" version="1">MLSHDVRSITTHRNLDKTTELRESQFVLPVDPKHRSTSLWLHGVIMLLTGMSLIVYPMSYAATLVSPCQNQQLNKLLSHSQPTFKFKNLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZJ5</accession>
    <name>A0A061CZJ5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765994.1">
        <property type="nucleotide sequence ID" value="XM_012910540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZJ5"/>
    <dbReference type="STRING" id="5866.A0A061CZJ5"/>
    <dbReference type="GeneID" id="24562349"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101370"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="484" mass="48126" checksum="5E8D10C8A3C96F97" modified="2014-09-03" version="1">MADSSGGDQPTHLATTVSIGKGEEGNEGIYGTYEGSTKMEHKGANVGNMGSQVAGASGILAPPSAGASGILAPPSAGAGGIPAPPSAGASGILASQAAGASGILAPPSAGASGIPASQAAGASGILAPPSAGAGGIPASQVAGASGILASQAAGASGILAPPSAGAGGIPASQAAGASGILAPPSAGAGGTLSSQEAGIRDILASLAAGIRDILASQAAYEGHRFSSQEAGIRDILASQEAGIRDILASQAAYEGHRFSSQAAYEGHRFSSQAAYEGHRFSSQAAGIRDILASLAAGIRDILASQAAYEGHRFSSQEAGIRDILASQEAGIRDILASQEAVRRDILASQEAVRRDILASQEAVISHILASQEAVISHILLQQEEVRRDILASQEAARSGILASLAAVRKDILESQEAFSIDILASQEADTKEILALQNTGTRGKSSSGEAVTRRSERLRATAKRAKSSSEEAVRGSIRASEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZM7</accession>
    <name>A0A061CZM7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766262.1">
        <property type="nucleotide sequence ID" value="XM_012910808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZM7"/>
    <dbReference type="GeneID" id="24562617"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103890"/>
    <dbReference type="OMA" id="FGHKHLA"/>
    <dbReference type="OrthoDB" id="361925at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1113" mass="123126" checksum="B77F49DBBFBEA90C" modified="2014-09-03" version="1">MMHKPSRARRANRKHGGSDLASTAADSCHSADAGIRGDGAADCAAVPYEIVEFKIRAASKVALLYGRSGRWAALARRGELVDDRTLKNVLRVKLPDYEHRGLEAGVLMLRVVKERIGSALRRPSKGDDTVKDITSEAFAAVVPKEMMYDKWRPTVAEAVALCAIWAIEVGGWSKLAVMAYRVLTHISRVHCIEYIKRLVDTFFTLARDACDLELMQQISLLTAVCMKSGSDKDKDRLRVMCLALVKDDEKNIYVDQVLATSLADIWDTHPCNLEMLPSGCKYRLMGNLLLRRREQETVIPALLQAAVGGSYDERKLALTALREVCGFIEYSAIREAASRLLHAPDPVDLGILSLAAILPADHEAALCYIRELCKQIANKVGLAGNTIEEMCAAAKSSVTHLVAGGGSIRKAARQHVQKTGKQFFTVRELVNAIGCTITRMTMIVEDNPEEARIAPESPMGTTIDAVALMAACLATLRQELVPYVGDLMRRILLLMGTPKRTLRFCTSTLKQCKKHGEFWENLVLMTCELVIMMIMPVMKDFHTSTVEERCVMAPFLKEIADTMHAAVRTAGPALVRYCCITKISESLSRMAGYMRMLPQQKYTAKVARRVCNTLQAVLQHLLQPVRLKDGGQNRPPRVEEEDLLYYRGDALLYISIGFNAICAVTVPRLEMIWIARRHPREEGARLPGGMIVTRPVSRESLAAVPWVGVSRITTLIEEVHRRGPNDAKTWSQLLKRFNAILSSFGHKHLARVLVTLAKVGNCPDDLLRKIRNQALSQLHQCDLLSCCGILYGLKRLGACDTELLQRFQKQVVDSVSTAQGPYPVVMLIHTYAGSGDKDTTLVLLREAVKRADQLSPQALAMVVVAASANYGQCKEVEAAMLQLLLAAAGRMGEMDLRSLTQLYSSIAKSGYAIREHVLDAIADEIVPRVERLTPQQSVLVLSGAAKAKHVHPRLAAAVVTALERKTVDSDPQLMLFLLSAIVKLNFQHSSLATQLQRALGMAELKPTQFANLVYLVGKWRLPEPSTRCLSSQLDRLIQCSRDTISLRDAALIAYGFAESGGQDDLVKAVLLAEEIARRSQDQHDQRTLAMINHAANKLHFQFPDLSTNSRSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZQ0</accession>
    <name>A0A061CZQ0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766074.1">
        <property type="nucleotide sequence ID" value="XM_012910620.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562429"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102170"/>
    <dbReference type="OMA" id="IFCKKAN"/>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0711">Selenium</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="925"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="3">
        <location>
            <position position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1111" mass="124493" checksum="E1DA62BEFE5FCE11" modified="2014-09-03" version="1">MYLQPRGASAVAGARLLARFRRGFAFRIVRVPKSDPQTSKYRAIHEELQKATREQLMTVYGVLAVEDTRKRLDLDYVQRLLERTVALGRALLPGDYAKVFMALRWVPAAASGFTSDLNEGVRRLGANFSTKEIALILRAYAALASRSLTTITELVQTFNRHIAEAEVWHVREVASALATLRVPVTGPVETFYKRAVALIPKHIAGMPADDIGIFLNSFARQRVGHDELLHFVDAHADRLVSEASHRNVALIANSFARAERHSRRLLQAVERRLHRELEKYWAGKRSTEICMEVLQPYVGACLDASPSPSAALGAAYQCDAAAAPVGDAADQLPAAPQQAAAPASAVPPKVIDVAMVFNAFVKLEEDCTKLLNAYIPWLNHHIDSESPTLSLVLLCHAYSRAGINNRELFMRVAQIILQRVNSLNCQQLGLVAVSYARAGQHVPLLFLRLADEIIYRGTVALKFKRYSFDFQSLEHLMQAFSRVGFKDQRLYVVLTTLLKRQLRAAGPDDISGEMIASMLTSMAPRRVEAFVPFITDAIVRTRDKTAYSTSALCRVLNAFVKLKVSHSKLTDSMLKEVKDRVNEFQIPLLINTLKALAKLKRYNLGLVKDSIKRCSLHLVHLTTHDIANMLSALNDFAFRNTSFLQKLAMCIKHRIADFDRNQLHVVFSRLAMLRTSDADLYRQLLPLLLKHQHEFSEVQLADISVCYIYVLVHFDYLQRELHLQSAPRRDSEALQQLQRMQHREISQESSSKPVSLQPREGESAADLSDPCSGEDNSDNGVSVTKGGDHRNGYDEQPVALASHRIPDPATNVLPYGFQDAILDAMLSRLGSKLDVATVFKVQTVHLYLRHIRRDIYGKLSAKALDVLRKCSAVRFALAEYMLTSSSAHKEVSHLLNLMGVCHRNEVQFGPYLIDVVPETGPARRVAIEYDGPAHFYAETTMRTAKSILKHEILNSAGWQVIHVPHQEWAQLGGFNVDSRIUYAVSTKQKLIYLERIRRLYEVRPWPAARPLLTPGPVATQARHFSSSLEEKRRRLLEVNEQILKEHLENAEAGTAGFEQPRQPIPPSATDHIVDELCNRLMEGSGDIIDIDAGDAGKPASPEKTDAKARKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZU1</accession>
    <name>A0A061CZU1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766317.1">
        <property type="nucleotide sequence ID" value="XM_012910863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZU1"/>
    <dbReference type="GeneID" id="24562672"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104400"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="6967" checksum="301EC08955A78156" modified="2014-09-03" version="1">MLVTLSPVTGCLGRHPVWCHNNLRTPSLRRLRLTLKIEATFSFYGKRKCPENSESSHVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0R2</accession>
    <name>A0A061D0R2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766419.1">
        <property type="nucleotide sequence ID" value="XM_012910965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0R2"/>
    <dbReference type="STRING" id="5866.A0A061D0R2"/>
    <dbReference type="GeneID" id="24562774"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105420"/>
    <dbReference type="OMA" id="AVNNECT"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="233" mass="26269" checksum="9E3F03751639B329" modified="2014-09-03" version="1">MSDWFGSVVNSLSGSTQSDSKQAEKASNDKNGCHIYAVVVMRHYAQNEACRLTAEYDFSPLPMYMAKISREVTDLVSRTTAQEAFPDQSKCVDMENSMGMFYVKATSDPPPNQLVFVVAVNKFCTRYQALQFLQEAMHVYKVKGDVYRDNVGDSLKCPALRALMTQYKGKRDVLVDAQSKLDETKQIVMDTLDKLIHRQGNLDELIAKSQDMTQSTARLMRDAKRRNSCCAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0S1</accession>
    <name>A0A061D0S1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765918.1">
        <property type="nucleotide sequence ID" value="XM_012910464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0S1"/>
    <dbReference type="GeneID" id="24562273"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100610"/>
    <dbReference type="OMA" id="CEHYETI"/>
    <dbReference type="OrthoDB" id="360894at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="419" mass="45589" checksum="33DBFAE389552977" modified="2014-09-03" version="1">MYREGRPVCELAAVAVDDRLAYLGFHGSHSSIAVFKRETMEFVGLLTRMCGSAGKLLALGASKKLVCFTSAGHIYIWDTSEQTVEHLLKISNDPLTQEGFVHPDVRVHPAAKVTPESLGECVDVDYLPGTSTLVSLGPTGTLTFYDLSSGTETGSCHPEHDEGTRALCLLVNTCLATFRERKGYWVAIGFSKGRATVVFLPVTGKVEEMDGEAGSGAEVDTTDLYSISRCTGERSDVQCLAFRQRSSSSTSMTVVAGCSDGALRCFVFKLGPDELQPHKSATYLHCRGAKKGAITHLVSGCSHDGSPYVVSLCVMQLPFDFHTAPLVDAKQSLADSSTFCTEVVLQTLLPDQCNTYQLLAQLREVVSDIKLGVDGTSFLLTTFDDVYVISRLESENGWSKPKKLVWQTPENMKLLSKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0W5</accession>
    <name>A0A061D0W5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0100960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765953.1">
        <property type="nucleotide sequence ID" value="XM_012910499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0W5"/>
    <dbReference type="STRING" id="5866.A0A061D0W5"/>
    <dbReference type="GeneID" id="24562308"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100960"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="345"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR93767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="610" mass="68128" checksum="7ADAAC3EC81BCE2B" modified="2014-09-03" version="1">MVGLTTGAPTAALMKLAEERSSKTLESTQPRYERIGRLLTILGAASGGNSRVPISVHLSDIYGKTKLGDVYDIHSGMRPIKHAEFEALRLGTSAAQTELPTISVAGWCKTVRMQNAGKLGFVIINDGSCKADLQVIVHEGAIGHDIVSKCTAGTTASVKGILVERPPKAAAAQDAPKEETLEAIAQKYEVHVCSFEGHRFEIIGENRDAAKYPIAKKYITHEFLREVAHLRPRSYFISAVMRVRSALAMATHTYFQRLGCIYLSTPLITTTDCEGAGELFQVTTILEGCRTMGDLSKRMLGGDAQKAKTLEEMELDFKKDFFKRRAFLTCSGQLSAENYTCAMGKVYTFGPAFRAEHSHTYRHLAEFWMVEPEIDFCDLPKNMEIAEEYIKFCIQYALDHCLDDIMYLESIGDAGLVENLRSFVRDRFARITYTDVIDILLQHEADFKAGLVSGAECMKREDGVEPQKTAFENPVYWGVDLSSEHERFIAEVVFKKPTIIYNYPSKIKAFYMRRNDDGRTCAAMDVIVPQFGELVGGSQREERPEVLEASIKENGLNAEDYSWYMDLRTYGSIPHSGFGLGFERLVMLVTGVANIRDAIPFPRYVGKADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D166</accession>
    <name>A0A061D166_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0106820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766559.1">
        <property type="nucleotide sequence ID" value="XM_012911105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D166"/>
    <dbReference type="STRING" id="5866.A0A061D166"/>
    <dbReference type="GeneID" id="24562914"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106820"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="217"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="439" mass="49238" checksum="AD6EC59914C72BAF" modified="2014-09-03" version="1">MGNAQGGMNNNQENRNNNGDSTPREKPPPPVFGRKKKKNLRQNVPVRIPTVSPSTKCRLRLLKLERIKDYLLLEEEYIANKIRLNPTKNKNQDDMLRLEDLRGSPMSVGTMEEMIDDNHAIVTSSMGPEYYVNIMSFVDRNLLEPGSSVLLHNKTNSVVGILMDDVDPLVSLMKVERAPLESYADIGGLEDQIQEIKEAVELPLTHPELYEDIGIRPPKGVILYGPPGTGKTLLAKAVANETCATFLRVVGSELIQKYLGEGPKLVREMFRVAEENAPSIIFIDEIDAIGTKRYDATSGGEKEIQRTMLELLNQLDGFDPQADVKVIMATNRIETLDPALIRPGRIDRKIQLPNPDTKTKRKIFEIHTSKMTIAQDVDLEEFVNNKDDLSGADIKAICTEAGLLALRERRMQITQADLRKAREKALQLKKGNIPESLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D198</accession>
    <name>A0A061D198_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766594.1">
        <property type="nucleotide sequence ID" value="XM_012911140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562949"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107170"/>
    <dbReference type="OrthoDB" id="365688at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="895"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1390" mass="157212" checksum="62E40C135178F7EB" modified="2014-09-03" version="1">MSYLRKDRVYVVSNFFAMAMAGFAAFMSGDFIRLLCFDTLGDESYWIFAYQMTMWVSTLAASLVKTPAAPSLMYCLRINIFFLVSAAVGFFMQWFESISFHFVIVIWAYITGLALVNAVVFASYHHSGSRGLMLGSMLSFATTYGVLELVKYWTWKHGELGKYRNIVLAYLILRLVMNCAAMSFLSSGAQETHFEQFDKAFELIKSGVMMEWLSGTLHERDVQLALKEVTPHYVSPVAGVRYIFEKSDLTVVWLIFLAMCLSCSIFTPYIAAANWDLSVFKMGHIDRAEHVGNLMGVIVAVTCKRSWFKAVGLGLVYVVHAALGSFLTYYVHSYRMSLRMPLEAMCVLTCVNASFGSFLTVSTFIHFFELAVNLRCTNQEEKTKLPQLCCRDDESSECLCSEQFCDENCGTKTCDVEGSKKVKIYIPPNTEEMYRLWLPGQCLLCWLYRHNPDEVCKIPCYMRTNQEQTKLDECEIYLLRNCKVSLCGYCDMNLLMECVKVECICKEECNIPLPNANMYKEDEECQKALKEKEKKHEEKEAAGSEATQPMQQGEPQQPATASCAAGQDGKVTETSEQPEETVSQITSEGSDEGNKDEESDEETDEKPIKKPLHEICLCEGKNVSIVTTSSSEFVVRESSCCDSKNTEPTPRQEDVECESDGREFKLSSMCCYSCCHYGLKVMMRLKAPNNNFHLMQQPYPGKFDPIGCLVFNGRCNNDDEHKKLGEEKKKKSDQKKREKEEKKRKEKEKQKQEKESQKKEKEEKEKTEDSEAKTEAGAKKTEDEDDILEVEEDADSLKYACPKSTLKSITRVACGENTKDDNGLCACCKTAQKASEEKKREKEKTPKKPEVPSPKPVTPAPQNTYPDHPECCHMKVQPTALPFHFKEIDLKRNSYVGALFFIILIFGTAKLIVAIAFAALDVKYGLDLSSNFNLIKPFYEKSVDPITYGINTALSNEDLLKQFTQEMEYSSPPKLAAMVPLQRWMESPSFDSIYEDNVRVFSTKPEESSTEVVDEVENADGDANDESRAISDNGGMVSSSIGLPSLDQLGEDDDVSSVIEEKQSDDVGSDKKTGDAITKAVKRSKKGTQKNALEPQTEEEDSVVNAEDEANNDSDVDKKAKGSPAVEKVVRSAIDGGESESGNKSDDEEEEEDLTLVGYEKKAMEAVLEQYKWLCNDLEYAFVENWVQETTDLKNKDDEDVEKIKRIRRVKWCLDCGLKVYAYQSADAIMVYLESMCEKWDAEMTHYGSAVTKKLKVVGDNVSMLSPMKMAKIGDHDWQAALTDAQITLWREASADAEKLAKFTKQDKQLREEATAARGVDMIVTMIALWEYRVEVINELTNDGEVFLSWRQFMHNWELILSWKENFLALYLEEYKGVKSLETDGAEAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D218</accession>
    <name>A0A061D218_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD superfamily hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766977.1">
        <property type="nucleotide sequence ID" value="XM_012911523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D218"/>
    <dbReference type="STRING" id="5866.A0A061D218"/>
    <dbReference type="GeneID" id="24563332"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110880"/>
    <dbReference type="OMA" id="SCKFSYA"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600527" evidence="1">
        <location>
            <begin position="23"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="323" mass="34796" checksum="4866E8FF7B711452" modified="2014-09-03" version="1">MNGVVALFTALVGAAALCGVNAKEKSLRRHPALTRQPNYFAVDIDGTFATPQKAAMKKNIAAFRMALNAGHTLFFCTGRSPGSARNLFGADAYRAMGYNGNPGVYLDGALTYDDQGRIIDERPLTPEFLEQVAMATKDECNKFMPVFQTADEVLTICKFSEKAQAVFKAYLSTNKIPIISVEELKKRRVYNVIVNNVNEVFNSIFSQNAEEGSEVSSVEGTYDPSSNYSLLPLPHGFTQVSDINASKADSIRALLAYYGAEPSDCGSIGDGLNDIDMLESTTPSIAVGNAVPAAIAAAHITLEETCDEAAFAKAMQKVYGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D321</accession>
    <name>A0A061D321_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Platelet-derived growth factor-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766683.1">
        <property type="nucleotide sequence ID" value="XM_012911229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D321"/>
    <dbReference type="STRING" id="5866.A0A061D321"/>
    <dbReference type="GeneID" id="24563038"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107950"/>
    <dbReference type="OMA" id="IDMESPR"/>
    <dbReference type="OrthoDB" id="361764at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="164" mass="18669" checksum="C50D37472BAB44DB" modified="2014-09-03" version="1">MQRKRGSSKKYTAKGRSRYVATEEEIIARNAEVAGSGSSEELTDEEAEESQPQVLRPPRRDEPENDDDDSSEEDSSDDSSSSEFEICNPNRSARPIEKTGVVELSRREREELQRQNFERQKMTLMAQGKLKSAQADLARLAEIRKQREAAMARKMEQMSLKGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3S5</accession>
    <name>A0A061D3S5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transportin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0203860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767414.1">
        <property type="nucleotide sequence ID" value="XM_012911960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3S5"/>
    <dbReference type="STRING" id="5866.A0A061D3S5"/>
    <dbReference type="GeneID" id="24563769"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203860"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="918" mass="101826" checksum="A70A2B0D6D7DDDB4" modified="2014-09-03" version="1">MSFAGDAAYAQLIAALEKSDRPDTQTQKDVADFITHFESTQRYSVLYFLEAALTAPALHVRQMAALCLKRAINVRWAELEPDVKSHLKNGLVRGIQIDDSDVRTVFGSAFVALFAVEGFENWSEAPALLLKLASESQNRIVRDTAAGTLLMLVEDMTANEHMRENAYANAAGSERLTVFVTKELLPRVLEQGTKMPEALVFTCRLLYTLMDHKSLSAPLFEEHFATFWGLMGSVAHSRDPSVRKCVIKGMIETWDRQPMTILDASAAVFSFLIECSDDVSDNTVQIEALGFWAHILKNRLEEPVRTRLHNALRSVLPRLIPVLIEHTRYTSWDYMSMDESHLEEDNASVPDRVEDVPPRPEGEMGADEDEESATWGTNWTTRKGAALALDYIAQVFGQDQEILQFVLDLIEKRLANDTDWEVRESAVLVLGAIARGSAYAMAPLLPKVVQYLIDLTQHPKPLMRSIACWSLSRFADWLCQPAADDSEQPWLQPVMNAIFSRVLDRNKRVQEAACSALASFIEGGGCQLLPYIQPIVQTVVKAFECYQARNLMMLYDAVSTLAQVFGEALPQSSCGAYLLQPIMHRIGTTETHCPQFLALMDCVNSLVQCWELMYAPHAEATVRRAMTAVFEVLYDGRNFELSDGATEMPRWDVIGCSAEVISTVVGAMQEQSAALMQQSFVTLEPSVAQKLGMDRQQAGVVDMIVLCCQCPAPSVLQSVFALVGDLAWHCSALVATDAIIASLSVHVSCPSRLVCNNVCWALGVLAQTPLGQQRLEPHFHEIFTKMVELVNREKEHILMQNLCVSMGKFANTFPQLTAPLIPHFIKPWLDFVSQTRNDREKALALSGVVNASCLSTDASAGDVQLALARVSLDFPPCCPELEASLRALAHRLSQTPEKWQALGEAGQQLLLERASASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3X9</accession>
    <name>A0A061D3X9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein S14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765870.1">
        <property type="nucleotide sequence ID" value="XM_012910416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3X9"/>
    <dbReference type="GeneID" id="24562225"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100130"/>
    <dbReference type="OMA" id="RFTRMSK"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="112" mass="13306" checksum="7E4AE2E3993A0AA9" modified="2014-09-03" version="1">MAARNPGPIILDPPFGFPSFKNWVQRDSLSRRLFRESEVNTRVYKVVYRNMGLKGHIPIDNKVGLYRVRMRCIFGGYGHGVFRFTRMSKMAFQQVAREGWLRRYGYRPDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Y0</accession>
    <name>A0A061D3Y0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767459.1">
        <property type="nucleotide sequence ID" value="XM_012912005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Y0"/>
    <dbReference type="GeneID" id="24563814"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204310"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13565" checksum="07837B17F7F1EA8B" modified="2014-09-03" version="1">MQSCGVTYPSDELFKPETPKLYYADGGPQFGREIVLMIAAPYVLDPPNCFDQVSVNGELKDLSEMSKSLIASASDHFVILKFNSELIGPYETLRYMPPLECRCVTKVVVLSAIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Y2</accession>
    <name>A0A061D3Y2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766948.1">
        <property type="nucleotide sequence ID" value="XM_012911494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Y2"/>
    <dbReference type="STRING" id="5866.A0A061D3Y2"/>
    <dbReference type="GeneID" id="24563303"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110600"/>
    <dbReference type="OMA" id="IPNPRVY"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000031">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="236" mass="27226" checksum="390DB2F77EBBAFE8" modified="2014-09-03" version="1">MPLVPIPNPRVFFDISIGGRNAGRMIFELFMDKLPYTCENFRALCTGETGLGYYLRPRWYKDTPIHRITTGFMCQGGNFNTGNSYGGESIYGQYMRDESYAYLHSKRGVLGMAKTRHKHSNGSQFYITFRPCSHLDNKMVVFGHLEYGEDVLDAIEGQGSMLGRPKRPVSIFNCGEIPLDCVYDPDIDNPVRRDGSLYIVKTDREKPIFCQQQWDREQSSKRVLPDEVYKRAHYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Z7</accession>
    <name>A0A061D3Z7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sortilin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0206090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767637.1">
        <property type="nucleotide sequence ID" value="XM_012912183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Z7"/>
    <dbReference type="STRING" id="5866.A0A061D3Z7"/>
    <dbReference type="GeneID" id="24563992"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206090"/>
    <dbReference type="OMA" id="FAPFYSV"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595944" evidence="7">
        <location>
            <begin position="20"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="8">
        <location>
            <begin position="103"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="876" mass="97245" checksum="2BA6268E94165E76" modified="2014-09-03" version="1">MVPRLILALLPALLLSAAAEDVGAPVPENKINSHLDISTPVKHDDPTHPANAVLQEPAKVAAVAEPSANESATGVAAGKKVSVTEISFDSLIDDLVWCGNNHTTVLLKTQSGRLYRSSDGGIQWTEITHLFQGSARNGSYKVDSVVVCETDKNVVVVIGDSKTHFISGNAGRSFVRLEFEGTINMWLFHPLKPSWALLSSWEGACFANENDEDCVHSIFVTRDMGRTFDRVARYVAQFSWGDITTNSEDRIYYSRYSIESGDQPKQDGWNNGISFMCTDDFGYSSSVIMEGGNKFLVSGNYVFVARVADPVRQTVNLYVSTDNAVTFNKAELPVELEERSYTILDTSEGAVIIHVGHEYEGGDIEVGNVYISDASGLRYSLSLPNNIRSASGECEFDKVYSLEGVYIANFRDDSGGMLNPRNKFKTHLDGTKTQIDQKRNRHVSHSKVEPNIRTVVSFNKGAEWHYLQPPKVNSEGKPYDCEEGKCFLHLHGITQYKNFAPFYSVEQATGLVLATGNVGDRLRFDPSQVNTFLSRDGGLTWTEAHKGAFIYEFGDYGGLIVMAQDQKKTKEVIFSWNEGATWFDFSLSKHDVSVNNVVIEPKCSSLNFILYGNRNGIGVAFHLDFSSLGQPLCKGIWSIDSSSSDYETWHPTDPHGNHCLLGRKMVYKRRKQASECFNGKEFRATVEREVCNCTPDDYECEIGFTRAIGSNTCKIDGTWLMREGCTSSSFFWADAYRKIPGDVCTAGWIPHQVAVPCPPHSPLSKGSKAVLSTIMVLAIIMMAIVYISHNDKLKHLFHNYGFKQFNYVAYTPVNAKKAAQRGAGFGGRFEPELGFIDAEQEQDEPTLLNYLSGNRAASNSQQQQATRGEQRQIELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4C2</accession>
    <name>A0A061D4C2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765975.1">
        <property type="nucleotide sequence ID" value="XM_012910521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4C2"/>
    <dbReference type="GeneID" id="24562330"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101180"/>
    <dbReference type="OrthoDB" id="365300at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="718" mass="80623" checksum="AAE3C457BA7CAEC9" modified="2014-09-03" version="1">MSNVRQITLPPDALYITKSIPEDENLEMGSPQECAGVEPRRSGSECASERRQTDDTYGTEVNTDDSSSKEWNMGSQEEPMSGELPQRSTESRGYSFNSTATSFLGFCNLTRGKFRQMGSKLRGSLTSIPRDMGFSAELSPMQRRKLQHQSMEFPTKHAASQLGNEALYGVQEDALFRERAASNPKSKRTWLPLRKKDSKQMPARVSEPVIVINQPPSKQNEVEASRKSSMVSHQSRQTVVQDMCGPMPSCYVITKDKDSLCSKFCLDVYTTFKLTLNSGKAYDFKQLMTVDKNGNEIRLEKQRGNAKSHSAREATVARRIEPLRKKFPTLTRIFPRLCRSARYDDAAINDTTLVTVVNKGSANLFILKFQGYCQNYMDVSPDYGWRRLVDEYTAEDSKSAEQLPKVASPVDETCAQRSYMYYREAKRVTHMIGLSELAINVACRALILGIGDGMIDAAEFPPFIKDMVMQQYEGMSEVLATPTSVDRGADAPGKSMQAPMYLESSFLGLFVSSSMSSVLGSEPYAERMRDSKRSYRWSMPEKADAPASAGESGVKHGGEPSVYQFIPIPDYGWRLLQRAHFDRKHADPALRSNRRNSAASKLRSVFRASTVAGLTPTNIYSNSVLCKVRPPHVDDSQAFVRADVGSIAMNMAEQLYRLEVRQRRREKLPKQTFGFKVRDQNVVVSPCGKRFKLIPEELILNVATLVHEMYITQACLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4J7</accession>
    <name>A0A061D4J7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0208000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767832.1">
        <property type="nucleotide sequence ID" value="XM_012912378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4J7"/>
    <dbReference type="STRING" id="5866.A0A061D4J7"/>
    <dbReference type="GeneID" id="24564187"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208000"/>
    <dbReference type="OMA" id="MEIAPFF"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595794" evidence="2">
        <location>
            <begin position="30"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="38"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="26868" checksum="D6EBD764C473D275" modified="2014-09-03" version="1">MVALCGTRSVVLLGSALLLSSTYISEGSAFFFGGEQKKEPRRLPPNVRIYNKSNGASFDEMIENNKKDGGILIVDFFAEWCRPCRQFKATLTDVAERYLRDNLLILQVDIEQEEDLAATHKVSMLPTMIIFKGGEPVKRMSGAAGFEDMVQLIDEVKNMGKEATEAVSEPAKQQKTEEVIEKTETQQTEAEMQSIEEVIEKTETQQTEAKKAPKVKTAKGPKPGKKGQHGKKTKNVKKQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4X1</accession>
    <name>A0A061D4X1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">riboflavin kinase</fullName>
            <ecNumber evidence="2">2.7.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0207680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767799.1">
        <property type="nucleotide sequence ID" value="XM_012912345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4X1"/>
    <dbReference type="STRING" id="5866.A0A061D4X1"/>
    <dbReference type="GeneID" id="24564154"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207680"/>
    <dbReference type="OMA" id="ESEDHAC"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="9">
        <location>
            <begin position="405"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="543" mass="58336" checksum="55436F6F93E56B82" modified="2014-09-03" version="1">MPVNQNAANSDDPIFIIDADCCIVDTHTALINCLGAVSNIDGSRIYSPWKDAEQEEPRVGSNGGPERQEHLDANKGVIGNGAITPAEPVTAAKAPQEETVHSLPAGGAKQLASRKELAPKGVERGVCASCNNGPHQSDTCLVAPASEAAKGAKVISTEHQGRLRELIRRIRDDSGVPNEVVEDAVRTAGCLLEEARRVKNERFESIDSAFGDASVAVVLSDQQHLLHESLPYRNCVHVTPFQQFVEDIALSSYQSRGELGVLQNLEVVLDRLCSEAANLKASSGRVIFVSHLPGAVDRLLKLVDVKVGQRDVKIEVALRENVVSRCANWSRDVRCVLYPKESVAVQAVAAELSKARKEGVAVVPKAALSAPKATGAPAGVTSDKVDLRCEPDLASIRGLGAIYVKLNKPLYIQGTVVKGFGRGAAFLGIPTANLDCGNIPHLVPGVYFGTCWLFGNSEVGEDKPLAAILSVGFNPQFDDASYSVEPYIYHEFKFSLLGQRIKLAIEGFQRTEAKFESVEGLVAAIQTDLAEHKIVQRCQDGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4X4</accession>
    <name>A0A061D4X4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766195.1">
        <property type="nucleotide sequence ID" value="XM_012910741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4X4"/>
    <dbReference type="STRING" id="5866.A0A061D4X4"/>
    <dbReference type="GeneID" id="24562550"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103280"/>
    <dbReference type="OMA" id="ICDAKCT"/>
    <dbReference type="OrthoDB" id="366863at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="375" mass="41620" checksum="7F262D891B849FB4" modified="2014-09-03" version="1">MAAAKVVTENCEGCSKLCSVYTGGTRCPKSCQLCILKKCDKNDRCQCYACTCGCQDNEDVKKGVKQCKDSNCDACKVLCQNLKAEQKCRCTFCDCGCQDAFKEGKRCYESTNKTCSKCKEKCKDSKDGACICYLCSCGCNGVNCQCCERCNPETRCQGTGKCDAEEVHGEKCPKGMCKQKAGSCAEVTCMCDDMGMEKRKDLCECKCRCEQQCPRILCDKKRSGGSNGQRGICNRSTKDECTCECQCNCNAYGKYYGKNGDVVRICDNDDNMHVYAIGKCRFKCTNCGRLCDQDRCMNWIRVIVIGLIILASLFVMRAIFPEKFRAIMTKIRATFASSPAHSGRSLNNLVGHRIPEETNVDRYPAFHPKTYAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Y9</accession>
    <name>A0A061D4Y9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767819.1">
        <property type="nucleotide sequence ID" value="XM_012912365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Y9"/>
    <dbReference type="GeneID" id="24564174"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207870"/>
    <dbReference type="OrthoDB" id="10397787at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28395" checksum="F3A81EF8E7502AFA" modified="2014-09-03" version="1">MVYNSLTDVPRDFREGIDWLVALKRTGFESNLKAISDAVFNFLAHKPAGACQLPAFQQVKLNVKKFLGQEGLKDRRIVKPMLERFNRPKNQKSDFFARFFQSVGENGGRQIENNWGITGENILTKLAKSVDGCNTFLRNINVPAQYKSAYSSKATWDASCSTKPEDCAAIFVGITPMLYAGLMSLWDATDESAFRLTPDKARKELEDILNAMRYVNPDCRSSLSRLEVVNALRGIGIDELGTLGTLAEFWIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D543</accession>
    <name>A0A061D543_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767353.1">
        <property type="nucleotide sequence ID" value="XM_012911899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D543"/>
    <dbReference type="GeneID" id="24563708"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203240"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="9456" checksum="58FDDBBFB589D626" modified="2014-09-03" version="1">MLSRLDCKVSWCVAAITVTGGLRGRRGGVVSPNYSIHNTDLSTPSRMLKIGVSGQECHQIELLCLFNLVFSACPPFQASPTAERMCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D547</accession>
    <name>A0A061D547_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767358.1">
        <property type="nucleotide sequence ID" value="XM_012911904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D547"/>
    <dbReference type="STRING" id="5866.A0A061D547"/>
    <dbReference type="GeneID" id="24563713"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203290"/>
    <dbReference type="OMA" id="FRNGDEH"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01617">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="1">
        <location>
            <begin position="181"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="31788" checksum="F4421FA89D281AF3" modified="2014-09-03" version="1">MSKFVEFLEPDVSSPSAYNFIGGYDDGDSPPVASKLHRHSVPSAYHDAVSTPTGKKRSQCVNLYDHYLERTPNEMNYPRLLQTFPRSHRQEHKPNPRPRDVFERLTDHRFFTGIHRERFDENGNGRGLAGREDVFLYDGNTESASRVHEVYSTVMRPPHERVLPRGTLGVQKYGVQIATPKLMWLYRNGDKFHDGTAFYVRPFIKNMDVLLFNMGKELTLIAGPIRRLYDQNLRQVTSVDEIVDGAKYLCTSGEPPAPAHRLRKFMSEWVVQRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5E2</accession>
    <name>A0A061D5E2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768112.1">
        <property type="nucleotide sequence ID" value="XM_012912658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5E2"/>
    <dbReference type="GeneID" id="24564467"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210760"/>
    <dbReference type="OrthoDB" id="367256at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="720" mass="77827" checksum="F6A86A7C6C565A85" modified="2014-09-03" version="1">MYPRDISDNSKVQHLPDLNGIMFNPNNTPAFNYVPQDPSLIPLQQAPQHVPMDPGYRNVALPPPCWPGSSPVPMQSPMPAMRQWQDGTIMMGGLDLQNQAFRSHVSYNTAPLVSTPGNQDMLNMEHLRPNLGTPPSGTNPQQLQPTPSPKSVVSGRGSLRDEPVGKSKGRVEPVMPMNKMLSEFEGPPITMFEPPRMDKPKDKKPYVPMVKQTRPGAATGPRRSGSRVRNEEGSGGSSATMSQIPTSKLEDFASKTFNNAVKSIAPPKIPFPWGPRPLVPPAVIDQAQVMNVAAVPQPCPPPMAVPHPNPLLPPPAAMLGIAPAVVPIPELRVQEGPLVGMDVTQPMTVPMGIPFDPNSHMPFPGPSVMTPVGQHKMPGFPMPSMGTAEGVPSADMMPQMRDPFAHITPRTPTIRVTTKAKLAPPVSMKSNMSVSGLSSASYPVQYAVTPAMGMAMPMDSTALGTPSPGPPPLGFAVNTAVPTPIATPIAAPVGMAVHTPLSMPNCIAPMVPITPGPLTISIQPPPIPTPQPAVQPPVMVPPPSAPANAGAVSRQPEESILDEIKKEKNVDNDVNKSLVSAPRIIVESYQQLLDKKRDRMRECLVEDCKSVLGERGKIDTPYQDTIQNGRKHFYVKDIVAKLLPYHMFYYENLEHKPKAPSMDLDALEERVRSLKSRVMDMVAQAKTTQQNYECTKACVDALRNVVRKRQATQCGQLGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5E5</accession>
    <name>A0A061D5E5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767964.1">
        <property type="nucleotide sequence ID" value="XM_012912510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5E5"/>
    <dbReference type="GeneID" id="24564319"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209310"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7689" checksum="AC2DA9799C018575" modified="2014-09-03" version="1">MKTLSMCLCHFSLDEQAHNSGVKRITDDNSIVYNIYIIMHISLILRSFIQHDLIATNAVRYGTIYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Q6</accession>
    <name>A0A061D5Q6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CG8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767518.1">
        <property type="nucleotide sequence ID" value="XM_012912064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Q6"/>
    <dbReference type="GeneID" id="24563873"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204900"/>
    <dbReference type="OMA" id="NHKYNWE"/>
    <dbReference type="OrthoDB" id="405939at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="193" mass="22801" checksum="EF0FE9CDFB015AB5" modified="2014-09-03" version="1">MHLNVIICRLQPHASLRGTIIKRTFATTPPIHHLPPPPPREFNEDGTPKKYRNSKAVYNHRYNWEAWTLRPAGVFHTVLVGEFGRQHRPWTAWVLQYPIYIVAVPSVLAVFTLAFLIQNMMLIGVKPKRYTVEWIEAQKERELAENTNPISRYLDRRRSERGPNWMLRNYMPSHPYFLFLGDYYKDPDAEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5S9</accession>
    <name>A0A061D5S9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PUL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767548.1">
        <property type="nucleotide sequence ID" value="XM_012912094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5S9"/>
    <dbReference type="GeneID" id="24563903"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205200"/>
    <dbReference type="OMA" id="HCAMSAL"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="203" mass="22337" checksum="6DFA8600E71D23B2" modified="2014-09-03" version="1">MIQWPLLERVPVFDFLKVLTASTSCDRLFNGRNSGFTIYSCLCSSIDEGGNSIPLLTVALQVMANLFHLTVPRTILLNHIDTTLRAIYHGSKYRIKMVQQAHSACIQNLIIASGERLRKWSQKIVGFVHCAMSALCGLGTDESWVGGVTLRYCCSLETLISLDVTAVGYVRESGVLKCIRDAVPPLVNHSVDVALARLSQVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Z4</accession>
    <name>A0A061D5Z4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmodium falciparum CPW-WPC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768317.1">
        <property type="nucleotide sequence ID" value="XM_012912863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Z4"/>
    <dbReference type="GeneID" id="24564672"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300360"/>
    <dbReference type="OMA" id="KHKPHVC"/>
    <dbReference type="OrthoDB" id="364977at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006387">
        <property type="entry name" value="CPW_WPC_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01492">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09717">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01099">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596004" evidence="1">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="94"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="182" mass="20461" checksum="C27F52BEF4C24CB7" modified="2014-09-03" version="1">MTSLVFIVATILGCVSQTDGSRIRKSYTDTQLDLFKDIAKNLKEESEHIPTTAQVVENMKRLDDAEFKRLDERIAKETAQLSEEHSSCGTVNYERDYSHACPSEWTLQADGSCWGEHYTGPCEAIQTFKLFTKADKTKFEHRCCAFWPARGSRKRSVSTSALIGGLHGIVDPHDGHIVPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D673</accession>
    <name>A0A061D673_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0206750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767703.1">
        <property type="nucleotide sequence ID" value="XM_012912249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D673"/>
    <dbReference type="GeneID" id="24564058"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206750"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600637" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="831"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="960" mass="106975" checksum="DFB17CD074E669F6" modified="2014-09-03" version="1">MGIYQVKVVFTSFIMILTSVRHIDALFCDFGGPSSSIRTNALVACHLNMEIYSVASVSCPHQVGDMEYIWHPSPTLDAPDQMNAYVSGYDALRSVAIANILHSESDIQPILLESIRSQNIIHVDVPKSEFIAITEQRLIFICGPRHMVLSDAFQRHLDRLDDAVEIQTFHRHSSSPLGQDVANMGYGMGVFYLNRGRAHLPLQGCGSRPSPLFAADNEVTVDSNTGVRSCVANPMSISPIGFVCEGRIQPEECMRSLFDQKGEVVATPEPHKYWNFDNHRPWVIAQYFDKLALPPIKGECRCIDPETGDTKATIVVRSKTDYVCDISSKIFRDRHRSIIGPWCSVVLHPGSTLTIKVPTQPVKPILMGDYYDRDIDEDVSGVPFSQLPSAYEYETEFLPNNLATLRQLKSIHDIDDYKETMYSTSLAGDALELDVSLMNRGEVTLKYNQDKPLTMRLGPNSFLFHWTLIARNKNVPDKIRAIVNVALAFTHHYQAVGCDRGSQRLFAPYVTKKYCVTKRWGNGIGETYECTYNRKLTVSWAGIHCSPDEELLPANCDSTGYDLYSNSIIGFPVSVHHATAIRMPGFQMLGFKNQNSPASYACVCVDARGYEKSRLILESSSSEQRMYIVNREEAIDNFVYHMLLPWHEAELSSEETSVKYLVLNSVSQESVVLGVGKTLFTRCTIEQGAYEDVNGDNIRPMWLPASYRNSHYTIRQTAAGPELVLASHRDSITTTPGGFEVFPMFSSPSNYELGIKSHKGAALISKDPDNTKYVPITFVCGKVPETSDVSVVTGDVLPSGGYAMSNNLHIGSSQRYKWHVVEVAVETTDPYMQGCGVTYESAELFKPETTKIHDADGQEMGCEIDIETAKEAAFYCPAPYVLDPPNCFDQVYVNGEVKNLTEISKSLIASASNHFVTLLFDSARIGPGETLHQTPPLECRCVTTKGIVLSTIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6C2</accession>
    <name>A0A061D6C2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766665.1">
        <property type="nucleotide sequence ID" value="XM_012911211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6C2"/>
    <dbReference type="GeneID" id="24563020"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107770"/>
    <dbReference type="OMA" id="RIFAWIQ"/>
    <dbReference type="OrthoDB" id="365585at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="478" mass="53922" checksum="DB04451DF2F8001A" modified="2014-09-03" version="1">MADYNQQLADAHLGVDRRTPTEVNLRKAAVLYEIFQRVGAIDLYFGLQNDPNANNRNTSSSASAYRHGDPRMLRQLSGESHDTATTVSEPKAVQKVFTVDELYRSRLLGRSDSDSFTPQPTDTGTFSEGVPDGGAADAPNDETSESIPRTTSAKNRVNSTTFCSARQAEDASLDQASARNSDAFSMDTNRSATQPQGSTMAVGPSKPSTMRSIGWSLEKSENDRSKSHFRSYAPPKPSESVAWKDDNGTLLFAESLDISRIYKSSSGVTSRASADNTNCSFMSFPYCSQPTIEPTACGCNPEKLRIFAWIQDWFVPNLLSAMSCFGSVALFCGDRLRQYFTPLEISNASRSFDEVFLSSLEFAILKDDMTRCYFNITDDRKEHLMMREVDDFRRLYMRKRINFEEFCLHFAPYLSQKPEEYTRNKSTDDADELMQRRALRRVLEKSLYGLSVERPNEFVNRQCMLKPYQMIEPIPPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6G3</accession>
    <name>A0A061D6G3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0301750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768457.1">
        <property type="nucleotide sequence ID" value="XM_012913003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6G3"/>
    <dbReference type="STRING" id="5866.A0A061D6G3"/>
    <dbReference type="GeneID" id="24564812"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301750"/>
    <dbReference type="OMA" id="GHSTHEI"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595503" description="MACPF domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="3">
        <location>
            <begin position="125"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="450" mass="50253" checksum="35CACCFF6B11C890" modified="2014-09-03" version="1">MKLHIAVTQISIILITHMVTCVRNRQVPSPAAQLKQEIQSPASPSRNNSQSNKSKSEDVGYTTARKYHGSVGKIGDATVSGKEDEELSQGQPETPGNPAEINTPLSTLKDVKPVVGSDAEQCNLFDKFLRQPHEKIKGLEYLGCGYDVTKSRPFGDEESFVDTGYTQPVVQFQWSCAEGPKSPTTPIGVWVRKEASCHKGHSTHEIKNAEALASMFSEDVVSSFGAAAVSLTSQTEKKNVEKLEKFVKRHGYALKSKCAVFSTGMFLSAEWNPTRAFQNASNVLLEYENKGKCSKIDDYRTNGSCAGYYELWKSFFNNYGTHVIFRLTMGGKLLRIVENLEDNEAKEKSKERQSSFGVQLSIINANLSMSNKKEDGMRKALNDQSSKYFVMGGDNLTSFDSSDSLKKWMESVERNAMPIDIQLTPISQFIPKEIRSHFWMAFKVYNDVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6L2</accession>
    <name>A0A061D6L2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768492.1">
        <property type="nucleotide sequence ID" value="XM_012913038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6L2"/>
    <dbReference type="STRING" id="5866.A0A061D6L2"/>
    <dbReference type="GeneID" id="24564847"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302100"/>
    <dbReference type="OMA" id="GYNLSMK"/>
    <dbReference type="OrthoDB" id="383103at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="113" mass="12667" checksum="30B24984C94ACA36" modified="2014-09-03" version="1">MAKVGREGGHLDSASSPGLSSDSTQRQGTAKGSKGLQMDRHSGLITYGGYILMRSVKLDNCNTDYLARQSRWRHFEKQQLFQRELSQKMNAHFVASLAQEYDPVAIRRPNSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6N6</accession>
    <name>A0A061D6N6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767868.1">
        <property type="nucleotide sequence ID" value="XM_012912414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6N6"/>
    <dbReference type="GeneID" id="24564223"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208360"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="8642" checksum="449522041195D017" modified="2014-09-03" version="1">MGSGKIAVSRSFEVRISTENLRLLRRTRAFTLRKTQISYLSRMLHACERESAAGFRGCARKFFCYAAPPSRAARDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6R5</accession>
    <name>A0A061D6R5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768424.1">
        <property type="nucleotide sequence ID" value="XM_012912970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6R5"/>
    <dbReference type="GeneID" id="24564779"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301420"/>
    <dbReference type="OMA" id="IRDAPIN"/>
    <dbReference type="OrthoDB" id="364344at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="176" mass="21261" checksum="07EF6923D8BD70AC" modified="2014-09-03" version="1">MRSVLFSLQKLRFYHDVAAVPSLRTAVQRPFAGFLGYHDLFQPTRSVQVQRVLSLCLNRRAYNPARHIDWVGIKRRWRAKQLLMKKRKLKNHPRVALRFRLTRFGWERLQQGRRGKKLHLSVQQRRNKKRIRFVSRHDLVKLARQMPGHRLRIRDPPLINSPNIQHFRRSTNKYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6T0</accession>
    <name>A0A061D6T0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GINS subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0301520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768434.1">
        <property type="nucleotide sequence ID" value="XM_012912980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6T0"/>
    <dbReference type="STRING" id="5866.A0A061D6T0"/>
    <dbReference type="GeneID" id="24564789"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301520"/>
    <dbReference type="OMA" id="HIIWQKA"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="330"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="477" mass="54988" checksum="9DE494ED5F338557" modified="2014-09-03" version="1">MFDPDGSQSTSFDFLRKRKRTSKRSQGDSSAASDHTSISRSTLTAESHTGSTRRSSFRGILSDHSRARSVTQSQSTTQSLSHNEDYYLPSRPTVDNELCKPLNYVIWARDQMAFGNNEILARPNLEHEFYRQLEILRKKLSARNFGASSSLNILESVLELMLDVEAGFRFLGSNANPFCRLSQIYINGYTFLRPVDLASYNFTCNDEEASVTIQQKRITGNVFAHQQLLQHFARQCEYLPSKYSGDYAYKPLPIKYDYVPNLVTKVLLQRAKRQPIVVKAIVDVPGVDLSPYEGYVFEELKTGEKAWLPIYVVERLSHFGFVSVDLPTYLTRSALRELRGREEQNQTLEKLPNDYFFEIAHLFTRWHVFERVNVPNLSNRNHVYCYISKVAAIIEDIKYQRIKKIRLALDKLSMRESVIVIANLQYSETYYINQFLSAYCDMRDNHSRADLQPNIQIESFVGDLENNLLDSLNVPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D775</accession>
    <name>A0A061D775_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0209650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767998.1">
        <property type="nucleotide sequence ID" value="XM_012912544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D775"/>
    <dbReference type="STRING" id="5866.A0A061D775"/>
    <dbReference type="GeneID" id="24564353"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209650"/>
    <dbReference type="OMA" id="QACNFTS"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="50"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="23832" checksum="337506EFD09CFAB6" modified="2014-09-03" version="1">MLSCVLRYRMLPRILFLVSLRITSTLRYSRLIERWTGSHLTPQLPESGNKMIGRTLPSDVLDSRLLTDDGGETTLRSILSDLPSDRKGLVMFLFPSIDTPFCTAQACAFSSSTELFQSLGYQVYGLTRVSGRSTADWIKRHELNFAILMDPDWTVIKYFRCTWMYFLINRSHAIIRRDGKVLALERGVPAHQSASRVLEIIKALPSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7P6</accession>
    <name>A0A061D7P6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0100690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765926.1">
        <property type="nucleotide sequence ID" value="XM_012910472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7P6"/>
    <dbReference type="GeneID" id="24562281"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100690"/>
    <dbReference type="OMA" id="HEEMSHA"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600668" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="824"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="954" mass="107641" checksum="9045C9E0E5888056" modified="2014-09-03" version="1">MANIGIIIRLSVCAISVCWIRSISALRCDFRDPHGLPSGQALILCNMDIGLSSSGTVICPRRVNDTEYVWHPQADPDEHTPVNTYISYNGVIRSVALSDVILSESEDRFIWFESNASKTKMHLEFSMDRIYAITEHRFIFICGPRELFLSEILQSHLDRLRSGVQMQSFSWNSSTRLAREIVKIGSGLGILFLYRGRYHLPLQGCGSRPSPLFASDNEVTVDPITGIRSCVADPMSKTRIGFVCEGVIEPVDCMKSLLNTNGDVVSVPAPYPYWNIHNHAPWVIAKYFNDVALPRFNGECRCIDPETGHVKARMEIRWKTEYVCDIASLIFRNRVRRIHDNWCSVVLHPGSTLTIKFPIEHVDATNIDQDLPSVIGRGNPPSYLFATKFRPKTLTVFRQLTRIYGNTYGEVMYRNTIAGDALELDVSRMSQGVVKLKYQENTPLALIGGLNSFFYHWTLKAIKGYEFDKIRAVVDVSFAFTHQYYIVGCDRGASSVFYPEMNTQYCSNVTMGNGIGEVYECSVYISMDDWQAGIRCQPDEDLMPDNCKSAVYDLYYNQITPFPESVRSATHQTIPGFQVFDFEFIESIPLSYACICVDENGYEKSKLVLESYGEKTRFYRVRHEEMSHAPIPYILLPGSEIGVLDEWPALPISIVLQYIYPTYATLYVGTTLSMTCALDPEVRNRTGNGLIRTSWLPNRPQEFHYVVIHRSHGRELIRKSHNDVIIGATHGFRVVNNTYLVVYKHLIIESRRGAILISKDPAHRHYVPMTFVCGKVPDESDGVIMTGNTLTSDGPETSATHIIGLTGRYTWDVVQVAVETTDPYMQGCGVTYASDELFKPETPKLYDADGQPQFGCKIDIKAAKEAAFYCPAPYVLDPPNCFDQVLVEGEAKSLSDISQSLVASHSNHFIILKFDSDNIGPGEELRQTPPLECRCTTVKRIVLSTIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Y1</accession>
    <name>A0A061D7Y1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765986.1">
        <property type="nucleotide sequence ID" value="XM_012910532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Y1"/>
    <dbReference type="STRING" id="5866.A0A061D7Y1"/>
    <dbReference type="GeneID" id="24562341"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101290"/>
    <dbReference type="OMA" id="HHNLNLE"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="773"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1084" mass="119429" checksum="7DF689F9F0B8AEDC" modified="2014-09-03" version="1">MGRDVGYSNLDRGGFASLTTQPSANDNMYGFTGPNDYLRNESAKNVDGKADIRGGDYRPGIGLTYGSTLNYVSGGETVKNGSAAFDPYRKASIWEDCATFSREASSDVLGRNELQKFEHNPYRSRYLNTPECEGLVTKHCQRLLHSYYGRADALSTSAVSGASKSLTFDDVCESALTSSDHLTSIATLSILARYHRIGYLLPQVGDPGSCAANIYAHVLNVLRVIYAASAGGVEAGGRNNVDTARRFFSLLGRGIWQTASDASDAFASLDRRLAQRISLLYVLCLHLLDVLLSSDCDCVEELLAADGDVYDTLGCVGCCFVEQAVRHGDRTGLSGNDLPEDRMVPNLGDRGAIFSKHWSVLNGLLSRGVKFSNSELLVKGVKALCNVLESSNTGRSLLLWAYCVYVRLCPAELSQNNHSIPRILFEYMTKCRSVLQLQAITGALSLCMRDPGFVRYADERMNPQKTFAIFVLHSCNLIHNKMDDLAVPILQMLHQLFDVCPKTLPDVANTMSGTTSLIERYSDTVGNAVETFLNVATLSLGPIQVIMALIMRRILLRCDVTKSLSADLRSKFVKHLIAVVGFRKTAGAAVGDAVGLVSKVALLDAFVQSGGLPELMSAMKDVNAKQLRLLALHSSSVSCDSLHKMLCVGDIATKLVAYDALAGYRADGMDAGTLVLCALCSVVKMCPDVSCLLREYASTYAGMSEYHGTGSLASEGKFLRALSGDANMADPTRSMRVAGLLCVHSIVASVYMSSESCKQTLIHALLCPEGSTRQQHQELVEKYKAQLASHRREVQRSHARLDAQARELQQQKDSATKQLEQLREEYAGKVERSRAELATAQSQLSAASSQSQQLDRECVRLRAQVSDLDQALRKISSEHAQANEQLREATTHRERLKNEVSGLQGQLEQRDRTIEQLRAVEADNGRLNEEVGELNAQVERVYRMLISLMSKHRQVEVDLARSKEDAAQNSRQLHERQLQVEELSNRCRSHENTINALRAAKEGTEGEVHRLGRELHALEGRLGKSTEELSALQGRYAQTSQALQSCEEQNRRLAEQLDRCELQLRQRGEQLSTIYSTFQDKKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D870</accession>
    <name>A0A061D870_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768914.1">
        <property type="nucleotide sequence ID" value="XM_012913460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D870"/>
    <dbReference type="STRING" id="5866.A0A061D870"/>
    <dbReference type="GeneID" id="24565269"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306320"/>
    <dbReference type="OMA" id="YMRIRKQ"/>
    <dbReference type="OrthoDB" id="366013at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="2">
        <location>
            <begin position="345"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="421" mass="46902" checksum="B98956557FD56471" modified="2014-09-03" version="1">MARYRGVEHDDAPRCDPAYVACGNTSPDGAHGSSRYPMAMGYGGEGLEPQAYEVSQTAGVPGYLEPQDTYCEETAQPAAEGDEVTSQVTEQVPSASMMYDYGAEYSTAQPMAVPGYEMGLVDSYDQSGGSKQMTPGISSSMSGGLHGSMYANMPSTEESIDTMNAQYWYGRNSMEQAMVPPSCDLTMYQKPMTPRYDGYRFPFPPYYPQNGQSYATYGSERNLPYSGSYGMHEEGYSPAKQHYSPRRAVSTGALPAPCKTPPINCYQMSPDHMAMRGWSAQGYPEGVDQNAMQNIPMINQSPMEQQPMQMPPRFGPDAFYGELTRRLQQEMKSKKQAASGRPKVSRHNYVCAMCHARTTPQWRYIKGTSVCNACYMRIRKQKLRQRAREKEEAAMKFESASAETEIPDDRRLMYSVGAPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D6</accession>
    <name>A0A061D8D6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0103200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766186.1">
        <property type="nucleotide sequence ID" value="XM_012910732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8D6"/>
    <dbReference type="STRING" id="5866.A0A061D8D6"/>
    <dbReference type="GeneID" id="24562541"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103200"/>
    <dbReference type="OMA" id="HDEYITK"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="789"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="988" mass="111204" checksum="3CCB799C8029FBBC" modified="2014-09-03" version="1">MFHDILMALAGHPGELIVAKPGEGGGFAVADGCQGILHAERSVVNSIVAIGYKYRCLEDFVRSVKDAEHNYTLSLLLGDDVAYRNRRSGVKVRGQARGDAQTKESDCVPEYRGNYLGAMCAGIEEYLQEYRSHLVTVEKTVLADPCLPLSTLSLLMAEQKQIIEALASIVRTYRDMVQRKVDERKPGVLRVDEMLCMLQSTAGGATVRKVRQSLYNRCLNLFKKQLRKWICNGQLSNHHDEFLVCRRRTTPDTGASGGHAPHGDISSSFGYEHLRQNVSDKAAEFEWTFVFYLSTGEPKWPVCSYQTWQSILFLGKAVRMLIRRYGNESQLEAQCRHVFDDWESNCDSAAAFEEAIEKYRIWVARAFWIYVNETVDVSALIDTFRHVYFLGHHDLYDDLMERSWFTMQTPRNLASCTDLKQKVRSMMSYKLDSAPSSRADPPAADCMDTDPAEMNGGHNDKNEDAFAITQGGSVARSRAGKPMFDFRQRTYHFNMSRRRWIDNELVLNVSEKRLEEPISGSVEASAVWFENRVHVANGFECGLRLELSQLEAAYMYTEEKMRGKTLGRFCRFAVVVQCTVDPVRLSSTALDQGLPAVLRDYFAVEFVVDYDNVASDDESILVKGAVKLVGDCVSAFVGGAKMAEAQRGMLCINEGQHRFNLTDGSRLDFQFIVRLKMTRKRLYAELQHPASGDSLILETDVLDTSHLLPHEFGDAYLGLMSYNGDGSAGGATTSVLKRNCAIRVSDWDYLGCMAAYDIAPLGEIDGPPTHEDFHKELPGLRMLEFESGINDWIHATMAYCCAWPVTILLDLPTMLCYNSVFQFILLIRRCVYGLESLCHLHPLMRRFGVNGKASKLPSSYIQQCVVEGSCRQMRAVLGHTGTFHEIKAAHDQYLSHVALNCFLDQRHVLEPLLQCADASLKFATLCYCAFNGSSDVDYGVVVPKLGEFSATFEHNMTRVYERLLLLSNDAKYSALGTFVEMCSFARHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8E2</accession>
    <name>A0A061D8E2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0308690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769152.1">
        <property type="nucleotide sequence ID" value="XM_012913698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8E2"/>
    <dbReference type="STRING" id="5866.A0A061D8E2"/>
    <dbReference type="GeneID" id="24565507"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308690"/>
    <dbReference type="OMA" id="LWSHTPR"/>
    <dbReference type="OrthoDB" id="442428at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF509">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128638" checksum="E64CF01F2E0977A0" modified="2014-09-03" version="1">MAPVGRADSDEFSGELVFSNRTLASAPENASVPAEEDIMRLPSLGEGYKSSLLEPSTAASGGSRASFMRWHSQGHLLMEMKRDDERMRREAKALFESSSCGDSMCEGEFGSTKPSESPDSDRHDSLARLSTVFFTSDSQLQPVNNGVVSFLLKTFRQLDESKLISAPFELTSEIEAFRSRIFEVMNKEFNSLSLSEALLTVAFNHYAGVSHPGYMTLDEYMSMMSLYKGVFANETMTRFVFDSMDRRRQLMITLNDFIAGMMACSPQAAHKVTSATGRLRLQHIFRAYDVKRKGYLDHDALRVLLTHIQQLARIANSSKVERMPSMNGSFIDIRRSDSLSESDPQSATSNLNEVLDLIMSTYENGFGYDAFYSSVESGLIKDSHLLLRSDKDFAELVGQHLIHALGRVVIPSEVAAKAEVTPLPVETPPPQEEEPKPAPVNEDVSGRSVDRTRKPSIWSSANSPRSAEATSLAPSPYASTYARDGRVHSLEPFYGLSGVRESPRSLSSRSHYGLSGLGTDRKPLFQPAPLKGGSLDATIRPFNEDAFFRKLAPYTKAGNFRSYDADNEPRQLGGKASALGLGLGMGIPQGASAFQGSAAVSEPELPAGNLLSTKALENALSATRGQGVARDVVPFLPKGENAWNRAKSVECHTEWMTFRKRADTDGILGTSRSAGYARISGLGMAGFGFSDLCDPVKDKMGISESMLTSNLNMSTTPPQDTTTETLALNDASPSMIGATLRRSNSRSQETTECKMDAPAPERHNSVRFEDSVPASSATAASDSDLEGILSRRLSDLCRRYRARFIGFNSCMLADSTIALKVYGEIYTRTFKCQDYWGVFERFHWCSYNELLELCDVVCGVVRQEGSVLHMEGTVQMHGPLNGSVLTLLESFNCLGWPLHGNTADRSVARAVDASQYAKGETTKLVFLGDLIGEVEGFSLETLLVLFSLKVLYPYHVFLLRGRREARRRDYKSALFREIYAKLSGNARQLKLADDEALLLQSAQELYHRIYDVFEHLSLAAIVDERVLCVHGALSKAFRSVEQLARVRKPVIVEQTSVKGDNRSRGAYANVHVRNACFGTLSDTVADASGEQFHADFTERELAYCMRRGGVEMLITAGPPTERGYSYAYGDRVLQLGGYTPGGIYSAALLREQRNTQYVITHRSIKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8P1</accession>
    <name>A0A061D8P1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767460.1">
        <property type="nucleotide sequence ID" value="XM_012912006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8P1"/>
    <dbReference type="GeneID" id="24563815"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204320"/>
    <dbReference type="OrthoDB" id="366735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="26912" checksum="2D774425CD03DFE0" modified="2014-09-03" version="1">MVGERDLIGSCDSNFKTHPFDPCNLCRKSRIRMGFKKRDLPKTSQLGSVISSILTFCCGGSDPLLTLASYLNCLTGRTPRTTGELVSFFHDFGIELHGYALKSLSPLCISLSASHPNSPEWDRLDGTGLDTVCRIRGSESLNSTHDHLKSLPKQFGDNLDHLHRHPQLLPTIYHSHALYPLVFDYTIFHFLNVLPCSQLFRLPTRFTSSTSRQYSFTGRGYSHLATTSTASMTPWANIVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8R2</accession>
    <name>A0A061D8R2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0104440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766321.1">
        <property type="nucleotide sequence ID" value="XM_012910867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8R2"/>
    <dbReference type="GeneID" id="24562676"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104440"/>
    <dbReference type="OMA" id="IVYERIM"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595916" description="6-Cys domain-containing protein" evidence="9">
        <location>
            <begin position="30"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="10">
        <location>
            <begin position="798"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="900" mass="102110" checksum="E163FEE8DAF97A87" modified="2014-09-03" version="1">MSRFRKYGAFSTSLLIVIATMIGSYLADGTPTGGGCTRGGPKASGSGPSCLKSSPTNGKYTKADTKRYLNDMKNMAISFGHIYGYEQRASDDLILLDYVGVPYPIKDYTKHNSALDEEISKAKSVDTYMYRIMQNTQWACLSEYNTPPTKKFDPKKSATTKDISRANNAVKELIDELSRNVITERHVVLKIQMYMTMGYEHLHSTNTKKLLSALTNMYDYGMSHKGRCTEKQVREKLDEDLSTIEESLSWSNIQLNALSDLASSLCKHHRSGNYGVFCDPSFNHFEEFRSGILSWYRMYSSINSRKMLLENALNVVKPLLNWLSVASMHSKTSKLYLKFGEMFSAVIPQFIWSGKEKRRFESQMRELNYAFAHLTTKCDESYHALSVDTILKLQREYFVAITFNDEPSLHLLMIHYYAALKSFEEYSRSITILKHTYGRQIRKFPRVPDAKEELRGLKADIVYERIMTLDCNLSAKMREIIDIKQDSTDRKATSIDGKQAYSCNQERLETRLNGLRSSYIAMTTMMIDYLELLWPVASEAADADYSTVVQSILYDVTYSAFRALQLAEENSTTFSDMERIVSSAFDSVGVIPMVSSTTSDSACYRELDSKHGNILSRRADLQEILSSLYIETDDEKTLGSLFQTLRNAIGADDHWKTNNAFKLFLDNRELVQRVLQLDIAMPRIQQLIEEFVDVVNASMPRLFEIAAGVDSCKTTYELEPTRTADNHSTSSNSEDIVEHLLTTSPNHHTVQTTKQLTEHFVEVHVETTDPCLQGCGVKSSSYELFKPDKPKIYDDNGEDSGRKIDIQAANEAAFYCPPPYVLDPPNCFHQVLVEGEAKSVIDISKSLIESASNHFVILKFDRELVGPGETLRQTQPLECRCVTIKGIVLSTIHIEHYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8W8</accession>
    <name>A0A061D8W8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ASC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0308960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769179.1">
        <property type="nucleotide sequence ID" value="XM_012913725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8W8"/>
    <dbReference type="STRING" id="5866.A0A061D8W8"/>
    <dbReference type="GeneID" id="24565534"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308960"/>
    <dbReference type="OMA" id="KWKENFW"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="6">
        <location>
            <begin position="73"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="37369" checksum="E7DD76A6522380F1" modified="2014-09-03" version="1">MIKAVDDLVLSTFGGKVHPDVCIVAVAIVALTVLRYLVAGYDGQKEPLCPPLFNILIDKSNVAKPKKTYKLAESLWYLCWHVTSLACTICLLAHEYGTHAEPKWLSYFLKDHKGMWFIYESVSDVGHEISWPNISMADGVRMLNLISMGFWMSCCLYIHWETRRSDIQILRFHHFTTVILILLNYTYRFHRIGLLIIILHDIPDVLLFTTKCLSYLRLVPDLVTGAVFLIYGTSHFVCRLVLLGAFVARPLFFNIGSPEIYEFAKKYMYSLPGGVLCICLLTILTVGWRRFASQRSQVMNIYWLNLIVSMIRKFASGAEISKCGHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D916</accession>
    <name>A0A061D916_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0303710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768653.1">
        <property type="nucleotide sequence ID" value="XM_012913199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D916"/>
    <dbReference type="STRING" id="5866.A0A061D916"/>
    <dbReference type="GeneID" id="24565008"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303710"/>
    <dbReference type="OMA" id="ANNMVCI"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="6">
        <location>
            <begin position="301"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="563" mass="62118" checksum="E6703D07BB184926" modified="2014-09-03" version="1">MDVDGGHQPEEVSVYNIADILRESLDSSIKWPLLDDLASRLEAIGGNSREMMKVNRWLKEQLESLRAQGASSVDGARRAQVAAGLLELVENKDAMRQKTLEEIVLRRAPLVESGKVELQRGVETANKAHMSFDVEDVIPEYKCATADAAAVDACINGKITRFTNLFKGYCESKGIACDLKPLKNFSDNDVTAYGRIGAEGDVPLNELNVTVQGTTVFDYGVKAQITNIHALDDVCLFPGQMAAVTGRCLEDKFGVRYVASKLHCGIPADAPMATNHANQKFKNQNIHISVVRGCLLTESLEPVSFNHVFNKIKRDRPHVVFFMGPFVSVRQVAVDGDGLSRIGDITFIYKRFFHEISLLADLSQLEGTKFVIVPHCYDVLSGYPLPQPPLNSSESELRSVEYPDNVVFLSNPGLVRINGVLFGVTSCDPVSGIANNMVCIPDEKRVLRACEQLLLQRSFFPSYPTSTLPSEYAVDHGMLRRLEFAEDAVPDVFLFATSSNNEPFVEFAGERAFVGCHSAAVPKDAVVQMTTEIYIAPQEVDSTPIRPMELENRVSLVLALWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I0</accession>
    <name>A0A061D9I0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767770.1">
        <property type="nucleotide sequence ID" value="XM_012912316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564125"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207390"/>
    <dbReference type="OMA" id="CIYIRVL"/>
    <dbReference type="OrthoDB" id="361394at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="3161" mass="348388" checksum="B7279EB358330DC6" modified="2014-09-03" version="1">MRVRRSAERDRRRRILAVPEIAASPPCELTTAAHISSTAVDVDEVVYCVLDSLVDGKAETERAATSTILRFARLQQDFTIRAILYFLEVQKTTESHQHALLVLLRKCITQSHETIPTGLLRDVLLFMLKELNFLGVSDVRHSVIIETVNETAVLCPAFSVEVILAFIRDLRQESAIPTETLCIYIRVLTHVFAKAANNDYIRSVDVVGQILSLYDPSTICVESGELCKNLVSLLCTLSKALHPLQEWQSAEDAAFAQVSNQLVEALSLEDVAHRRFAAWHARYRAYRLSVDKPQNVQSETMPLNQLGALIDGSSPEETDVLWSSRSAEQGSQQPRDRPVVRSVRLGSRKRIISFAAALYASRSLCQHSEQSSVGLRDAENPAVGAPSSTLTQTVGRHQSSMGFDSAIGAPNVADGNAWRTPTEVDGGAAASNQLNVQRSASSIGTGQVSKEQVGLGLASQNGFPSSGSMFKLAALGMPMSEDAGGARHMPHQKAGSRNAPRTGAHMVLQTLSGPMGIPTVGVPAGFHDVLAPLFTLLLERSLASIYTNPPFTSTCLEALFAMALLSKHVSDVAIARYGLSLLDSVLVRFYQYLPNTPYQPVARQGRKSVWMSLHKESSDTYRNKIVTIFSSLGSYGDKITMLPPAPLVMCLLHLCKVLLRRRPHIVVCQLPNICEVLFGLLIAMHGCGKVALLASCDSSFVSYYIDEEDLLLNRSVGSAFLDVGCASSCKDFVRTVVAACRFMASSVDTRCYFLEFLFRKALKGSPREVTVALFMLGWSCSHPPICEALTDSRRRSSAPASLGVSGAVFWRLIDVLHTLLGRMPAASAHPHTLRLLLALINHLSRGDWLLLHCLVGYRTAPNYPADFYPENAAMRITRPVYALIDFVFSLKVVYDLEKRIGENNNKVRDLGMKLASGFFRKMYCGQHATSYDLSLLVCGSRSFEKFLLPHCGDPMITYLLQLLLTNSKMSVFTVLRSLSQLFAWGNAEAFSGMCSTTVFTRAMAFVLVYLHDPVNYFGEAFAAAKVLPYLSELVLGERLELCDGTRPKSHYCGLDSYVLSFDRGDCYGHLSGVDHIVLHFEKVSRLFQKMVALSSFESVAVVMVNQLARICQSLKPPTTTYASLLKLSNVQASSSLTMYHRLGILHIMAACSRCSVDLCSSLIDFLLGFRGQASQVAWDAKFSSDSGVPPFSTVLGKWAPLTLNVCEQMRYTMLQLHEFNRHSAQAAAGNNGSPTANGVISTKYPENVDRCSEDISIDLSLQDDRLYFTVQADDYLHHESQTLRGLILGALGMHQQYYHCVLWKVYYGLRSRLPGSAVIFTKFATLSFGEDLKVVALTALAYLYARAPANLVDAGMMTGLHVNHSETAYDTERPTPVASPVSRYIEQLATPTDEAALVDMYTFCFREGCEKAVCTDLAGDNGLLRCVVAPMLFFLLHETDIGTQHAVARALHYVMRAAKSNHAARAICRFPYVALNRVLYFVASLTSRDFAANQLYDPTPIRQQCAHMFNRARWDLNFPAVRAFESAPLKPAADGVTCSNVALAFFSATCLLSDYVTSADDVLPVLHLVLSFGDVWEGLKRLPSSSSDQLSASGSIDVKALTVRFMKNCVAKAGWKRLSQVLSMALFMSEGFPAGMVEHRVSLVLGLLSDMEPSSVTKVHEDDFHSGNNIQGSLEHTSDGSEVIDAVKGDSAPLSATDHVETGLAAADAQQSAESSPQENQHEVLTVQNNVKNAAKINAADDGEEEHWGFVDCVLLLWAHMLHLEYGSKMREALHACLKKLLCFEKSGQSLFAASEDHLDKAIALDKTVAGPAGQEPFVTAITHGAQTALNAGDMRGAEKSEPQYSNIPAVTTEVGNKTPSKLPYIANVERIDLLIPKGSLMMALLCCMKYLSASSCLSGPFANILQLILQQRYSDLDHQHLESILATIFSNFSSSFESHEVPCSTHNFVVDLAQTDFEVLCNVIFAPNCNYSKSFKLSVTALITHDPFLTLQLLDFLERCMMAGYQHLGYARHSVSMDYIMDFVGHIYVNCDAGILHSDEGVRFVTTLVIHSLCITRSNSRDSLPTLQRLAALVGQLGARVNAIRHGLDAKEHVNVEPKGMQQGNGNVEATKEDNNLRRVASKLRRSCRSLVTSSESHQQQFLRLLDRLLHCQNEFKRGLLSACLSILCNLLREKALRRYTTAIIGIIKKIGSLKELRKFYYRSVHYFLLGLDGAECGLYTHNCILKGYRRRRAKVNGSIKLNISADGDDVYLRTELLSAVRNDGGANSPTTALALGAFSKGRTENSINLLQSLLDELTASLMNDLSKPPSVGNMHCLERAASSLIRFVTESRGYRVRDFRALVAQLLRMHTVLIGTDQRVLCAFAELYLAIADWLESCISRGYVMPVEVQRHLLPPLGLSILHGSVSMRSQRKYRRLTRVLAGLLSDAFPIPLSVNSSSRGWLKSVLLRRPFAAHSKFPYLQLCMCGCNNPELTHTTGERFCVCHAFYLLDLFSSCFPSYCWNVELGMTENIDSEIARLRRDEHVKRTSQVLFGSLNDFTPSQSLVLGDLGSMSRDETFTDESGDFVDISSAYKVRVEHYKSGSQRNALSNMTSSQSLGAMMTARSMRSSSFNNAYFDHKEYNESHAVDVSSGRSGGPLRAMSADSKRVGIHTQGNIYTKLLSLSPSRSFDNIRTVASATPREAEMPLWLDLSLPNHDAKRFLYQQSPHASRGVIGDESQLNEEAENESPVRVASHGDVGVNLNSSCGSLCTSLDVPIDHVSDPSRVSEVSTTLQRSLMFGHQYGEGPVGEASMQLSTSDLGDSISEIDASPSYGYPQAELSFDKNRIRLNRAKRDVSNSRGSSEEHLSVTGSSRSALSYPLSYANAGIAEFSEYKPPVLVKKGLTEEIMKIEDSLIPSAYIGSLRSLSFRWPSRKRSLGKALNSLPCLPSLLPILTIADFQVEIDGHLRRINVFNGERKNSLKSFDTSTVGQSLSFFDISNLECIWNTTLYTSPMVYRFMLLSKYLNRPKIYACIREDQGVSRPPPGQGAVTPTVASPYTAAQPDRPASLGCDQPQEPTVPESVMINAVRGAAAILHMALLHLTNEEVVLRQHIVDKWPRCFLEMARYNAVLHFEALAQTVSKQLCKMLEGSSGLLKRVLLESMEMFAVVLSSSNPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q1</accession>
    <name>A0A061D9Q1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homolog of Uncharacterized protein MAL7P1.13, P.falciparum</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769602.1">
        <property type="nucleotide sequence ID" value="XM_012914148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q1"/>
    <dbReference type="GeneID" id="24565957"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313190"/>
    <dbReference type="OMA" id="WSTRTTE"/>
    <dbReference type="OrthoDB" id="298686at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009618">
        <property type="entry name" value="Erp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038835">
        <property type="entry name" value="Giardin_beta-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37027:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_148, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37027">
        <property type="entry name" value="KDE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06780">
        <property type="entry name" value="Erp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="342" mass="38870" checksum="7E4663DAC758AA6C" modified="2014-09-03" version="1">MVLSDELRELGSGALDSDNWKPLYASWSTRTTEHRNSSASSGSASLSSSHSLKSGLSLDKLREEAAGYLSQIKLGMDSREFLTEPHQETTTATKLHAPKPSDKYDRVKKLEDSLCGLQSNVESKRSNILEEIYQKINNLEAKIAESEAQERRACSEVTKKIDAIQRSITTAKTKHEAETKEAVVKMEAVYQRFTEALRAEKEQWKQAEKDAVNDINSHIKRIRDDLDEMKKSKTHVASYLRQYIDNELPQLKMRVASAGDDIAAMEKTIAASTHDDLLTLASFIKQETMQLNEMKRNTMLEVNKHSELLKAQLVKEREERIQMQQRMVSLMEETLKRLGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9R1</accession>
    <name>A0A061D9R1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0311660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769449.1">
        <property type="nucleotide sequence ID" value="XM_012913995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9R1"/>
    <dbReference type="STRING" id="5866.A0A061D9R1"/>
    <dbReference type="GeneID" id="24565804"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311660"/>
    <dbReference type="OrthoDB" id="366344at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="595" mass="67378" checksum="4B02508421023E83" modified="2014-09-03" version="1">MNGQELVLGAFGVYLALFLVIAITSIRAILADDGVDKHTFWDDDVVVDIDTERPINFLNCACYGLSELREVVLRAWSPGIEDTPDGIGATLRRSRDDWQILAATRHVILPTQPVHVSHLMVLKCLRQGGCDDFLFILPFHEAMQTNEIAAIDSETKSKLQVKLIRGVSRAERDCVHVLPDDEYQSFKQDAACRDSCYPAVYRVHLDETIGAETTTKVRVDYYLGKPYTPLQRRLQLGEQQRVAFGLSTLLPSPYHSVSQKTRLILMSELNIDVVSLHVYATLSEIAENIFLCGPFDKVELLSSGEPMVLTIDCTDSLEYIPQLHKQISVPMCPFSGHIQIAEHYVVYNDASPVEGHFSLETLREIDRNEGARRGGGNFVTYMDALFPQQATKLRYYDDIGNISRAYLIDRNASHNYKSVHLLPRYPLLGGWKASFTVQYRLPPCILHSRKEVGYTPIDRFALNNAFRVADWIWNYVKGGEFVVCAPLYPAIYYMYIHRATHTLTLPPGAKVTRVDSPRDAVVEVKQRQRMVLGAAVSIQEITVNVSRLALHGMEPYYTEQVLVAYTVSAWWLWRVFGVVVLHAAAGWAAVHFWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9S0</accession>
    <name>A0A061D9S0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BBBOND_0107780</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766666.1">
        <property type="nucleotide sequence ID" value="XM_012911212.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D9S0"/>
    <dbReference type="GeneID" id="24563021"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107780"/>
    <dbReference type="OMA" id="DHNLSIY"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="434"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="533"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="917"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="976"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1331"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1531"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1755"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1989"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2056"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2658"/>
            <end position="2770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2814"/>
            <end position="2852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2867"/>
            <end position="2909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2929"/>
            <end position="3004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="724"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="845"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1066"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1133"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1175"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1205"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1233"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1331"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1371"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1566"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1992"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="2064"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2658"/>
            <end position="2688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2697"/>
            <end position="2711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2734"/>
            <end position="2746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="2754"/>
            <end position="2764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2815"/>
            <end position="2824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="2827"/>
            <end position="2836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2889"/>
            <end position="2902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2987"/>
            <end position="3001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDR94480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="3274" mass="356160" checksum="BCEF06AABEB24176" modified="2014-09-03" version="1">MADTREDMWERYVVVSHLLMACSIGHASLQTSGFYEIVMYYVNNKTCLAILYNYVFMMFTFFCHLPVYAFLGHLTALEYEQLHETARNYLMDAVLFLLLSKPRLNGRELPVTMLTKYLVLLVALKCFHILLYVRLSNVFQMDIPSYFSMLRLAAFIYVLSMVDCRLLCMLWRDLNWKNTFTIWVVFELVAMMLVCTFSFMRYVVNMLDFFYESGLKNKTTLLFYLELMHDVMSLLCFTIFVLVFYIHNPNHMPAYMLIDILNVLKNLSDRISMLMHYRKVVKSLESRYPKPTEEEKERDGSCIICRDDFDDDSRKIECGHVFHMSCLKSWLFQHSTCPTCRAPIEEYEAPRAEDFNIWRQVSVIENHVVNTSRRLWRGAMRLLGREPPQEAPEYDPASVKEYVENCAKNLKEPILTRLNEERVICKFALPPAEEGEASSDIETPAGEREDSNLDFGDANTGNDANRATGELTGGSVSSGAAAGSSASNRDMVDVLADLGKMAKALADIKQLTEAAAAVTEVAEAAANVIDAVEPPADGNESAEVAPAAASESATTPEDTSKPELNSAIAATPGPEPSVAEQCMAEAPQPDVKATNDETGTPADANVDPEERQSGSFNEEIVESVDRNTVDDGTSDVEPTPKDDAEGDVTITKDNIHVIDAESDAPAKPTGGSDSHSDGGISKPTPQNDDADGSDALDRPNVNDTVDESNEVLPVAQDGVPTAHDDEDDDDIFVDACEEFVESPAEPAEPPAETTKPTDTERDMVKYINECVRAFSGEIVGETGDQEEADEVMEGGPLNDLKRDDERDEIANAESPQLEEASFVLVEPDYEDGSHNERVVMRRDNAAQSAPRSVSRQIQSRCGSITNIFHRRSTSQSIDEARNNEDGEFDPFWTNTVYQRQAQSGSSKSKKNFFSSLFRKKGSKTMDNATRVEEVRPDTGGPTKSNSSSWSKDVKWPKPIASYFKRLKLPDAISEKVSELRNSAKKKSASFDSKDKATAAPVRKAPPTPVRAAQPTPFPRFEPSDPKRSLSDHSSSNTSNDDDSDVDRRNAEDEYRGRLYANDSEVYEPRRRYDDEDERRRHSDDSDSHGDSRKSGDDYRNRRYSIDSEPHVVTRYSGDEEDKSRQNSVDSDAYEPRKDSDEEDKSRQNSIDSDAYEPRKDSDEEDGSRQNSFDIESYKVKRHPDSERGSRRSSGDSDSYPLSDQNSDDDEDDREEKSSDDESYAISGKDSDLVNDNAQSSKYDSFGPLIKLSSSSASSAVDGDVHSGSEAAAGMASDVDAYNMLDSDSEWDPFVERVVTMPPESDNYSDFEMEPTEVVEGKLIDLVESSHDSMADSDHMSEDEMSDENPVTESAELAVHEIVTAPVESDLETDRSAELPVREPGEPTAHELVTEQVESYLETERSDESPITHSPELTATADVSVAVDNASEDEMAADVPIEPSPQSTINEPVTVAAEGDMENEVSAESPVSHSSERIATAEEIAFEDSGYETETVHYAPEESSTEPAINEAMPALAESAYEDENVDEIHVTESSEPTVIETEVPEMVSDSEHGRIETPSSPPLETTADDEVSPDTNDEPEPESSAMVPYQLPQPPAVNTQLVSAVERDLEVAMVGVEHIVDGTVLNVQRIVEQTVFNMRVIVENTVANVQNTVESASMEVGARVERNEDPRIDEVEMQVERSVNAAVAQAESLVELTVDAAVANVRRTVNAAVHNVESLVTRTVDVAIATALGLPPLPSAAAAISRIILVRRSDSEDSADTRVPPNEDNLGSDLSDYPDDLVYEDMSDFNFSMNPSDVTEMPTIDEAIGAEPIERVVGLAAVTYLHAPIEHAFVDAVSGEPVVHDTTASYAATERVDSAVVTHVEEPDVGASARTYVESASIQQVTDATATEANVHYTITDLVDETVDETVADGSAGQIVEIAAVDDVESLITEEPVVAYSEDSSMRETTITEVNLEVTEEAVDTIPSELMVQEDAITETVYATTVKRVESDDSANADDECTDTDGHFSSSEDDVVSDSPDPVVDEISAADANAETVVENTNVSTDVAMGIVENDVAVDSPANVEDEDVDSQANVEDEDVDSQANVDDEGVDGHTPSINEAVDESSSESSVDDSSLTAEATETREEPVLPDSVEQDVDQIAHTQADTPIEDEHVAADASEQDSAVDTHAETTIATIDQAIDGGSTEQALDEAVATETDSPTVQEDVCESPEETTYMDTYIPTTEYAIDEASAETVMDETSGTEADNESVVETTDTTIDMTTEDVYETAVAVPAEPVVADSTVEDAVTETTEDFVDEVPSERFVEESTEIVEVSPDTDLIDLGDDVVDSAPSESYEEEPNETVEVSADTDLIDLGDDDVDVRDLDIPINEEAVDSDPSDFVVDETPVTDADDQIVQDAIPDTTEEHFADEATVIDVAADTTDECVGEVSEEQFVDEATVIDVANNIVEDCVREVSEEQVLDDSAAEEVDGPITEEAVGERSEEHIFDEATGMDTEIIDAAIEGATESDSAEPTVEETAVTEISSYENEEQVDLDSVEPAVEEAAGTTIDEVVDTDSAEPTVAETTTTEVDAEATDAVVDTDSVEPAVEEAAGTTIDEVVDTDSAEPTVAETTTTEVDAEATDAVVDTDSVEPAVEEAAGTTIDEVVDTDSAEVTVAETTTTEVDAEATDAVVDTDSVEPAVEEATTTTEVDAEATDEAVDRDSEEPVVREDGVTQVDNAPTEGSVAADSTEPAVGQSSGTNGGNPSTDGARAPEDNDGDDDEPEPDVPTYCRRLMLPPWLRESRNRGSDPDVKAKSGMLKLLRKLKYIRERLTAFASPQRNQTPPAISEDEAAENSEEQNGAADVPVSSQSVPEAVETNVTANDDAETAVNQESAAPEDESNVVTTDGDNFPNENVAPPVNVVSGEDDVKKPSAEELARIRRIRMAKLSREFEDDDSSGAPEGDADKDAAVTAESTTPEVPPVGNDNDAVQVADGDDVVLPDPTVTDSSSASDVGEGTSSVSAGEPAAAEIVLVESSDVPEQPEPAESNSGSIVPVNATQSSDIVVANVDNTISSTTNAIVSLASGLANMTPNDMWNLSNIASTYRRRMASSARGGRRGARPRSNMEAVNTLLTEFQFIEEHSDCDILFPDDDAMNDRLLSQLSSSNLPSYKRDFFLAYCKMIRMWHLTANGLSRADGVYKTVFETANASRASAVTNRRQRGLNSDIWNSLSCYSVSPDRIKELHNQYIKRSFNYQDGVWRMHGSPVPVDVIEDMVSSMALMDAIIKSEIEKVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9S2</accession>
    <name>A0A061D9S2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768908.1">
        <property type="nucleotide sequence ID" value="XM_012913454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9S2"/>
    <dbReference type="GeneID" id="24565263"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306260"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="129" mass="14551" checksum="0ED2E4866814AC0C" modified="2014-09-03" version="1">MGNGQGWRGLTRCPCWKDSKTDCESDCKCCAWCCKQCNESHECKHCKATKETKKCKHNGCGTCKNWFTCKCPCCQDRKGPMAFAIFLGVSIVVGYIIYCLVWVPNPALDGLRSYFSGYYPILGNKENFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9S7</accession>
    <name>A0A061D9S7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0313530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769637.1">
        <property type="nucleotide sequence ID" value="XM_012914183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9S7"/>
    <dbReference type="STRING" id="5866.A0A061D9S7"/>
    <dbReference type="GeneID" id="24565992"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313530"/>
    <dbReference type="OMA" id="NPRQEQN"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR97451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="21204" checksum="2BCDAD4FEB12D237" modified="2014-09-03" version="1">MDSTKADVSQGSADDKSANQDSGQKDRRQAFDCNICFEDVVEPVVTRCGHLFCWGCLLNWLNRGSDTCPVCHACVTKENVVPLYGRGEESKDPRSKPSEPRPAAERPEPHQHDDHNNVGAAFGGIAISLFALPISFVMPFHFNGHMGIGLTNLFTVLTNTDQMTPEQRRAHINSFVLIMLGLTMIAYIVLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9W5</accession>
    <name>A0A061D9W5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0108320</name>
        <name evidence="12" type="ORF">BBBOND_0108330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2015-08" db="EMBL/GenBank/DDBJ databases">
            <title>Babesia bigemina intergenic region separating two elongation factor-1 alpha genes contains at least two promoters that are also functional in Babesia bovis as heterologous promoters.</title>
            <authorList>
                <person name="Silva M.G."/>
                <person name="Lacy P."/>
                <person name="Suarez C.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Puerto Rico</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KT439182">
        <property type="protein sequence ID" value="AMB20706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766720.1">
        <property type="nucleotide sequence ID" value="XM_012911266.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766721.1">
        <property type="nucleotide sequence ID" value="XM_012911267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9W5"/>
    <dbReference type="STRING" id="5866.A0A061D9W5"/>
    <dbReference type="GeneID" id="24563075"/>
    <dbReference type="GeneID" id="24563076"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108320"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108330"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="407705at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000255">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AMB20706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="448" mass="49223" checksum="1D27057608AC5494" modified="2014-09-03" version="1">MPKEKTHINLVVIGHVDSGKSTTTGHLIYKLGGIDKRTIEKFEKESTDMGKGSFKYAWVLDKLKSERERGITIDITLWKFETGKYYYTVIDAPGHRDFIKNMITGTSQADVAMLVVPAEAGGFEAAFSKEGQTREHALLAFTLGVKQIICAINKMDKCDYKEDRYSEIQKEVQGYLKKVGYNIEKVPFVAISGFMGDNMVERSTNMPWYKGKTLVEALDMMEPPKRPVDKPLRLPLQGVYKIGGIGTVPVGRVETGQLKAGMVLTFAPNPITTECKSVEMHHEVIDVASPGDNVGFNVKNVSTSDIRTGHVASDSKNDPAKAAVSFTAQVIILNHPGTIKAGYSPVVDCHTAHISCKFDEITSRMDKRTGKALEENPKTIKNGDAAMVVLKPCKPMVVEAFTEYAPLGRFAVRDMKQTVAVGVIKSVEKKEPGSSAKITKSAQKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA66</accession>
    <name>A0A061DA66_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0109330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766821.1">
        <property type="nucleotide sequence ID" value="XM_012911367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA66"/>
    <dbReference type="STRING" id="5866.A0A061DA66"/>
    <dbReference type="GeneID" id="24563176"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109330"/>
    <dbReference type="OMA" id="HYNTHFA"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="87"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="303" mass="34960" checksum="ACA26897A4C808D3" modified="2014-09-03" version="1">MRALFDAIHQKKQKVEALKKENQQWIRKADEIVSEKKRAEEDLHQGLQRKKGCIEKQIENLSACYFATLNKEAKNSGHAAVEEAKEVPDAEIIKHLRSHMQPALLFGETKEQRFKRLYEVRLKNNITKHNQNVFVETIIGRSRIGGWISKMLKQWQQEVIAKREEDLQQGNIAEAKRRDAMLAQTKKDLQPLVRLLKTQTLEEDTLHKIYKVVECCEKGEYKEAHDAYMILAIGNAAWPMGVTMVGIHERAGRSKICTSEVAHILNDETTRKYIQMIKRLLSFDQKTAPVDPSKLVQISTSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA86</accession>
    <name>A0A061DA86_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA (guanine-N(7))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0307810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="1"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769063.1">
        <property type="nucleotide sequence ID" value="XM_012913609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA86"/>
    <dbReference type="STRING" id="5866.A0A061DA86"/>
    <dbReference type="GeneID" id="24565418"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307810"/>
    <dbReference type="OMA" id="FLMESID"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="9">
        <location>
            <begin position="397"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="720" mass="82201" checksum="2DD6034A0E3CA9BB" modified="2014-09-03" version="1">MELKIPKKSGSAEPLPSPVDTAPKRRTPRVLTTRSNPLAIEGCSVFGVSNSAATVSGAVERLVRESMACTRDPLSVRCVFHIGRLMGLTQNRDIVLPVETECVLDNNDSKVAFIPEVPPTCINALYMDMFTNQAGGHRLAPDSDHVEVEIVSSSNVDQRTPGDALEGFHHTRIYRVPYSTDEGLRLSEMQCCDHNVLNTMHVYRPQSQYHYRLQTSSAVAKEDESDGVGLGMTLKLCFRYMRNYKTTAVSEEKLVRWELNIVDHWDVVLNDEMTQLPIERLFECFTTCLVSKHSDMSAFPFFDREVVEDGRRHYVQLSVHGSQLGKQFQRLTECKANRFGYIVSLVHSNLRMILDSFDSMSVDEVPTADFYPNLFGDTAEAVQFHYDTRKLVRQKGSAIEALRRHNNLVKRVMIACYVRRKDTVLDLACGHCQDLDKYATVGISHVMGIDISLSEIMEARRRYSEQLRGRRFRFKAEFHHGNLLDDRVYATYVRNKKFDVVSMQLAIHYIISDEASASMMLRHIHQALGDKGIFIGSTVCCNAIAKGLIANPPHQTSDDAGQRWDFGNSIFRVTMEDASMEKLFDAATGQPYPPDALISRLENQWGLKYHFFLMESIDASEYVVPWRSFAELCTRLGFRLLETFTFPEYMERAPALFRKLESSLTANVLENVLHHLRVMSTVEMSTEQREAFMLYRIFVFEKVTGRDRLYMQGVKIRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAC5</accession>
    <name>A0A061DAC5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein RRP5 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0209820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768015.1">
        <property type="nucleotide sequence ID" value="XM_012912561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAC5"/>
    <dbReference type="STRING" id="5866.A0A061DAC5"/>
    <dbReference type="GeneID" id="24564370"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209820"/>
    <dbReference type="OMA" id="WSHYLEI"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="6">
        <location>
            <begin position="121"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="389" mass="45077" checksum="C073307FACD81431" modified="2014-09-03" version="1">MGSLGKSANRRVPGKSVKRKSDKKDKTAKQTVESEYEPVSWDLADDILSQVAADKEQPAAPAVEKPSKPKKKRARVEATKFDHSAELAKESKIRESEQRIAEEELAETPDSVLGFEKRVVAGGNSAALWMEYMAFHLKNGSLEGAREVVRRGLERIDFRALQERQTLWVAYLNMECLFGDRVKEVFQESLRFNHPKTMHLKLVNIFVKNRRFEDAVEICDSALKKFGKSKKVWNTYLRLLYEHVRDFEAARQVYEKCLVRIPSHKKVYMITSTALLEFKHASADRGQMLFENLLLDNPRRMDVWMQYICAYIKFQLEGSGKKRPEALRAVRNLFLRIITLDLKPKKMKVIFQKWLEFECTHGDDKSKALVQQKALEYVEHVEAKLKPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAE4</accession>
    <name>A0A061DAE4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766886.1">
        <property type="nucleotide sequence ID" value="XM_012911432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAE4"/>
    <dbReference type="STRING" id="5866.A0A061DAE4"/>
    <dbReference type="GeneID" id="24563241"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109980"/>
    <dbReference type="OMA" id="EIDSECA"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="235" mass="26394" checksum="CF6283B46036402A" modified="2014-09-03" version="1">MTFTLTTSHAARKFAERLMQEVPNRDSSSASCADKGAHDHGKECAGSAMHACGHDLSKERELFERSLPDKYRACTMFREEAKAAFTSQQYKLAEKFYEKILIQLDYTFADDADWKAKFREMELSTHVNLALTKFRLQEFRKAIYHCKMALFVDPTNVKALVRRGLCYMSLCSYDEAEKDFLKALEIDSECATARSQLSLIGKRRAAGQKSERLVCSAMFSANKASSSNASGGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAH3</accession>
    <name>A0A061DAH3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">-Ribosome-recycling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0401880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769882.1">
        <property type="nucleotide sequence ID" value="XM_012914428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAH3"/>
    <dbReference type="STRING" id="5866.A0A061DAH3"/>
    <dbReference type="GeneID" id="24566237"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401880"/>
    <dbReference type="OMA" id="DSENVWI"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600740" evidence="4">
        <location>
            <begin position="28"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="114"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="30841" checksum="B2A11AA47763E8D3" modified="2014-09-03" version="1">MVPRWRLAQVIWLVIALAFSLRHDLLAAALSAYPLSRAGVCAFVSRRPAAPRCLQQLDASRKKKNRSQGRTGKGGSDGRSDDDEVEEFFVSEADLEAVFAGLRSKLKESEQFLSNKISRLALHRATPSLIESLTVELPGDSKEKQLQYVAQIMSKGPYELHVVPLSAVHLDAIFVSLSTKLVDYKVSMMADRVSVVVPSMTEAMVRQARSVVKETLNEVKTQIRLTRQAVIKKLKHLHQAMSDDMFFRQQKEVDAVVKQSEKRVDEVANEALRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAH4</accession>
    <name>A0A061DAH4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA methylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0210470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768080.1">
        <property type="nucleotide sequence ID" value="XM_012912626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAH4"/>
    <dbReference type="STRING" id="5866.A0A061DAH4"/>
    <dbReference type="GeneID" id="24564435"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210470"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="481" mass="55097" checksum="7F7BC89A099330EE" modified="2014-09-03" version="1">MVRLLFWMSLNQEYNELIEPELESLAELHGITPEQFKLSHYRDENGDSEPVVEDNEYNLKFNDYYTALVRGEEIDDKRIRKSQQNVFYYATVPSEEHAIAMFDRSIQLKAIIDVWTEGQRYSNILQNIRTQHQHNVEQTLVGKSWCVKYNCFNAKNDTDKLVAILEEMTEVFERAGKVDIKNPETKIAIIENYFDDKSRNLRTIYFGRYLRDRSDIGYWWDHYALSKRPILAPTTLENMLAFIMANLALVKKGSVVLDPFAGSAGSLITASHFGAVCFGSDIDMRILKGWGVAHHNRNLPQSGKALSNMHTDTADLPTHIYTNFKFYGLTTAEMLRFDNRYTVWRSMGALQNCRKEWVDAIITDPPYGIRASAKHRRLLHDGTGNEAVHCLIGTLLDLAESMLVPGGRLVFLLPTKNDRWEVQAKTYCSHRLTDALHVIKRDKLLVKHLGLQSLTGGASRFIVVLEKAPTPISSTEVEFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM7</accession>
    <name>A0A061DAM7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0211060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768145.1">
        <property type="nucleotide sequence ID" value="XM_012912691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAM7"/>
    <dbReference type="STRING" id="5866.A0A061DAM7"/>
    <dbReference type="GeneID" id="24564500"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211060"/>
    <dbReference type="OMA" id="WGALFDH"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF13">
        <property type="entry name" value="ENGB-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="5">
        <location>
            <begin position="74"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="292" mass="32609" checksum="6D3A27B02EA4F7D1" modified="2014-09-03" version="1">MNSAAAVRGLLNRPTVAAPYLARPFVNIYDLEGTTEAPFLSEANISYAARLFEKRVNPNPVYVADTVDDAPRRRTPQVAILGHSNVGKSSLLNSLLYGKMLPRFAKDVRSNAKMLKEPVFAPVSDNPGRTRHMFTFDLGGDLSLVDLPGYGYAKVPDVRQMCPQAFTYASQNLRNEWSVLVNKYLTQAPSLQRLLSLIDSHKGPGELDVKLWEMLQEMRLPFQVVLTKCEALKPHELHLVCQRTVEMLKAYGDCVHPYVHATSALRQLGIAELKLSIAHIAYTHAAKRNIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP1</accession>
    <name>A0A061DAP1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S12, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0401100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769804.1">
        <property type="nucleotide sequence ID" value="XM_012914350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP1"/>
    <dbReference type="STRING" id="5866.A0A061DAP1"/>
    <dbReference type="GeneID" id="24566159"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401100"/>
    <dbReference type="OMA" id="MNDKICE"/>
    <dbReference type="OrthoDB" id="414309at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000192">
        <property type="entry name" value="Mitochondrial ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="34367" checksum="B92295F7CA778874" modified="2014-09-03" version="1">MRPDLILRSSIRVTGAVAALSSGVKLRMRAAGLTATTSSLHHSAHGPPDSSVGCNANESYSPCGKRGVMAASAASHRRDWLQPSALMGIQRSFIAAKRPLGFHLCRHFSTRNISGRLFYRRRPKMIPRYKPKNRRSCWLEGCPQKKGVCVTLRVVTPRKPNSGLRKVARVRLSTGRTVTCHVPGEGHNLHTHSVVLVRGGRCQDVSGCHYKVIRGKYDLLPVKNRASSRSKYGIRLSDAVIEKRRLRKNQLHVSTELDREVFNTLLLHDWVNPDGSRRTEPLGPDEPVPVDIFNFNSRLRSIVHANKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAR7</accession>
    <name>A0A061DAR7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769834.1">
        <property type="nucleotide sequence ID" value="XM_012914380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAR7"/>
    <dbReference type="GeneID" id="24566189"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401400"/>
    <dbReference type="OMA" id="CTEVPLM"/>
    <dbReference type="OrthoDB" id="28939at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051888">
        <property type="entry name" value="UPF0148_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537:SF1">
        <property type="entry name" value="PROTEIN ZNRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537">
        <property type="entry name" value="SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="20472" checksum="C4DB2EF359D9377C" modified="2014-09-03" version="1">MDDLHGSGDGLSESSTTEEMARLLLAGWTMLADTCSECRDVPLMRNNDGALKCCRCKKESRDASHRVASASSEASRSVPTGIGERHKYSIVSEYGLDSCALSGIHGVDGDRVLSTVPVVKPAAPVVATEGRRLQQLCLLRVELSKALDRYTGLLHHSNENVSCDVRSDSEVLEALDRTLRLLSTVESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV6</accession>
    <name>A0A061DAV6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-like protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0310300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769313.1">
        <property type="nucleotide sequence ID" value="XM_012913859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAV6"/>
    <dbReference type="STRING" id="5866.A0A061DAV6"/>
    <dbReference type="GeneID" id="24565668"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310300"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="176"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="477" mass="53982" checksum="27FAA8AB87A89728" modified="2014-09-03" version="1">MADSQTWDTEQRRQQAAIRTRMGWSNCMPNCVEALYTRLDNIAKSVRHCIRKEPSGDPKTGSFAILKSSLVIYIVVFLFSLVINKTTFHGRCIGRVDYSLTDINAPYYSPLGYSACEHNTNSAADSISFYSNGEDNGYPSIGALELNASFSAYYGPKWRTLNILGCADTNYIRHYGEWFRMFTAIALHGGWLHLLNNSVAQVIIFYVIEPEWGFLRTLVGYLVTGYGGYLVGVVFVPCLKQVGSSGIQLGFIGAIVPYCVEHWYAMGSPELILFLSLTIFVVDFAAMDKTVSAHIHVGGYIFGLLYGFATIKSVALFDRGVPYQRFVIRYFSRWMSDAKKAQYIRAIAKSSQSEALARFQYESEAKANERHWGCIKHIMGIYPFGPHRMRRRDIITRVTALTIMAFMALFLFLGLYDESTYTSVITNMTGIFSSACTCCYIKRDATNAYQALQVEFLKGRYFCFSSIEYAERYCVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBL3</accession>
    <name>A0A061DBL3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769508.1">
        <property type="nucleotide sequence ID" value="XM_012914054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBL3"/>
    <dbReference type="GeneID" id="24565863"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312250"/>
    <dbReference type="OMA" id="ADNIMRE"/>
    <dbReference type="OrthoDB" id="361139at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="154" mass="17643" checksum="6F0AFF997F9B539A" modified="2014-09-03" version="1">MCDADWPISFESHLYDSQLLAALRGTLKYMLEGSYISKSTADNIMREAAELYHRLLRLNYVKLPSHYMMGRLQQYHHNKHAWYFTVYNPIVCLGYDQASLSAPVNTVVVDENYSHQDPARITSDQPLSDARAAFCYPGYVKIKAVIPYVEPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT7</accession>
    <name>A0A061DBT7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0313340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769618.1">
        <property type="nucleotide sequence ID" value="XM_012914164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT7"/>
    <dbReference type="GeneID" id="24565973"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313340"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="783"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="912" mass="102446" checksum="B412D0722CD378DA" modified="2014-09-03" version="1">MLPDPDGLLTDNAISRCHVNIEYFGSATVICPRKVDGTEYVLHPRPNSYEKSDLNTYVGHDGGFRSVNLNKVIVTDTPAEFASVVLDQSQTTIHINLSVVGLFHMNERRLMFICGPRDLDFTNALQRQLDRLNRAIHMEEIPWEPTTALTEEIKKVGGGLGVFFLYRGNAHLPLQGCGSRPSPLFAAHHEATADDTSEVTSCVVDPMTESRIGFLCEGRLEPEDCMKCLIDPNGENVIPPTPHLYMEFDHNRPWVVAKYFKGFDLPPFGGECRCIDPETGDVKAKIEIRTKTDYVCDIASMIFRNRVRPISGHWCSVVLHPGSTLTIRFPAQAVDTGPSDNNSSASLVFKRAPKYLFKTDISPKDLNMLRQLNTIYEIDVYDEILHHKVIAGDALELDVSQILRGEMKLTYHPGKPLALIAGTNSFFFHWILKAINKYTFKSITAAVNISFAFTHNYRILGCESGAESVFDPDISRTHCSTKSMGNGIGNVYECTFPIEWGNLNTGIHCQPDGELLPNNCESTGYDLYSNSIILSPEPVFDIQLNDDTPISYACVCVDQFGYETSRLILERNKEYYHTYHVFRQEDAFTFPPYVLIPWSDADLSSDGLSVPKSPMIRNISPETVILHVGTSLFMHCYPGEQNVGNNERITTTWLPRRFELFYYSINDTLHGYELTRNKYENSISTTPGALDFTYLTIGGTTVYQTMVLTSHRSAIIISKHTTHKQFVPITFVCGKTPETSDLSVTDDVTTTKDYPRSGSDVMELSKGYTWNVVKIYIETTDPYMQGCGVTSSSDKLFKPETHKLYDDNGQEIGCMIDLQFARKAAFYCPVPYVLEPSYCFDEVLVDGIIKNISEISQSLVASRTNHFVTLKFDNKLVGAGETLRQTPPLECRCVTIKGVILSTIQIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU9</accession>
    <name>A0A061DBU9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768540.1">
        <property type="nucleotide sequence ID" value="XM_012913086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBU9"/>
    <dbReference type="STRING" id="5866.A0A061DBU9"/>
    <dbReference type="GeneID" id="24564895"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302580"/>
    <dbReference type="OrthoDB" id="335757at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15721" checksum="BB06FF3836CF6D42" modified="2014-09-03" version="1">MIGRADIEGSKSNVAMNAWLPQASYPCGNFSDTSGRNARGLKGSIGHAYTVCIFTGNQNQANFSPFGPREISVLTEFALGHLRYLLTDVPPQPNSPPGYVFRGSDKARKALSLRNKQDNIKGSGISPAAEPPTYATPLKSSHKAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC43</accession>
    <name>A0A061DC43_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768690.1">
        <property type="nucleotide sequence ID" value="XM_012913236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565045"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304080"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2225"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1421"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2287" mass="256645" checksum="7408C9A30FD4B5DD" modified="2014-09-03" version="1">MAPQFKKLTDCPENLREAIDWLIQIRHGGDGQGLGKLAKALKKLIEKVTDDALRSLSDEQDANNKSSDSDASTESPSSSSYQSPSNLLDEIDKRLVKVKDNIEAEKEKLKNHDMPETRQAIKHLEAKSESLEIVKQFAKFSEKHLIPEGTGNMLNKFCAGLEHLLGYNSGMYTGDGIVYGDCDRLRDAVLMFFHGLLESVTNDDNVTTYDGYIGEPNKLCNVIRNLYSSIGRGSEEFGKQVDSVSGWLNKYNEQVVTLTNKVKEEIYDVRNLIDIEISYISSLKSSNLRKIQNIYGNHVDAAVSRMKSLKGNKNGFAGLDNALRDMLNVCLGKIETAVEVLTNSSKNEAFIKSLQTLQNTFKTLPEDLESFIITNFNVTVKDHKNKVEVFKGGIESTINALRDTFMKERLKVALTDLKNAVICANTNALNIGGLNNNVIRTAISAIEQRLKTADDVEDSAALLGLKTGIIQTQTNLIAKELNGAAHENTKELKDLGASFEGPDTMIREHETELSKLVHQAKENLLQAVACAKDNASNLGGLKNKTVAAAIDAIQKKLKDINEGAQEIKTFQDLKNLRSHIIDGQIAKIAGALNPDTRALGVKSGLQQLATSIEAPEKTFNRLHQVSLKELTEAAQQSLENIIAKAHECITTHGGINNKTVKKAIEKIQDKLAKETDSVVTMKALTELKTSFMDDEIKSITMILNKSALTSNVISGLAGNTTSIKAPEKIFSDTHKTTLDNLASNSQDDLQNAIDNAIKYVESSQGSLQKKIDKAFEQVIKSTDRKTQAKELAQRMAASLKDVKNGINESYSESSHIEGKFTKLDNYIENMKGGYEAKLQTDSTNDDSEIKRWATSTISLIITNSLTEANDTITKADKDYMTAVKAQLVQIKSKISQFKKNADINQLVDATSNIVTHFASIQSAIKTKSVYEADKIDRETYFNNLMRQTTDTVSILKAAFQKAYQSSAKAYLSGAIKEIKEKIVTAEGLYQQAVLELIQKIESTVSAMEDKADRDMLGDFHTSLKHFEDIQSAITTKSVFSEDIIERQHFFVNLKSQITNTVSTLHEAYKNAYKSSAKSYLSGAIRAIREKVDEAEEVYIRVIDVQLGQVTFTQLDETSFKAKSARDDISANLVKPFNKLQDAVQANSAFEDDYRERKRCFNNVKKLIEITVTSLSIAYKEAYQKSAKSYLSNAIKEIKDKVKKAEQTYQKRVEEEVQKVFARFKEVNDSNFKDNDAREGLKRFFDDEFNNLYNAIQNNSAFKKDNASRMSCFENLKKIADNSVRTLVSVSEKFEICVASAKAYLDKAFTDAESGIKELGITIRTEVNSAFEQIIAEVYSMFADERKASLKAVKSLVDKQSMKVGSIIEKDRITGIKGLLRWISDKIVNLKKDDFKEIVSTIQAFHKEIYRYFKYQIDGFDDEQDEDDSGSQRHPQSQDERSKNGLPARPAPPTVLRQNGDPVPGRVGMTRPTSARGQTFTSVSSPKCPIEHYIDGVEYHSARMFTALSVGRFTHQSRTICNDFMKFLESMRPLNFGGNSDPLLDIVKSGIQSFLTELKRAYISAYCGSAHDFKWEIDGDNCAKIFLTSIPDMQLHLDELKNKCNPQVKRWSENQINLMTDPGKFFAYHGYIVSERHKQNGELQNKCGFWGKTIYERLVGEGDKHVYSSNPNNLERLYTFVDRYRRVCHLKCTESPKPPTTINQMLHWLCGLFYTPMFNKLNKYFETLFDETTGKEFKVTFPARTGMNIIQKVNAAYLTGMFNNVALASYKILVAILGYGDADGRYACDFYTNPHDLEYPTNTDKCFDLLVEILLRLNHQIRFLFKQCHNGSTAYGWRDCLYGKGVGGSRWQCNDLQCTECVSGKGCKTHPTCGIKSPLQSFLEDGLPGFLPHKFEKPDCKITCSLANHNGIPCKTPMGFRDLSITASHIRTGQRIKDVLEGFCGKTHESLNLLCAYLLCLLRRPPQTLGDMFAFYHNFLEHWKGDSGYRDHAQVKQHKHDAFDEAVKRANFGITDTTLEITSIQYTKVHDPKNSDQKSSHPEGDLFSLLACDANSTPALPCGRYVQPLSLDVRCIFSKTYADLYLSWVVYTTEAFYKLLEKLWKECCGNCNTPGNRCFDKSCIKTCPVKYTNETGISITPPPNTKHEALCNSIVNCQDSHQTLFKYGFTFGSPYDLSGANDGLEKKRTCQDFCNALAKVCDGKSVLAELVRIKIPAFLWAIREKFFYTLVALWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVGKLAKLTYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC44</accession>
    <name>A0A061DC44_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyprenyl synthetase superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0400840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769778.1">
        <property type="nucleotide sequence ID" value="XM_012914324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC44"/>
    <dbReference type="STRING" id="5866.A0A061DC44"/>
    <dbReference type="GeneID" id="24566133"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400840"/>
    <dbReference type="OMA" id="SLIAECC"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="469" mass="51711" checksum="CCB3509287A080DE" modified="2014-09-03" version="1">MLSCVSRLVALPAQGPAFSVLRCQRGNGDATTSIVTFLKHRKALFQTWKSPARMLPGKRCPCMLLRFIQQALEWRSTYERAIYLSKGVLRLDAAQIEAEKRRAAAELSAAESCMEERTLVEQNIEGFRQRILSQVFTDNDAVNEIAKYVLTSQSKLFRPRLGLMIARVISVCSYAGAQGVTTPTPDGWPESPIAPAESSDDVMERVLRLLQSYEIVHAGSLIHDDILDDAETRRRLQSVHLKVGTKLAVLVGDLMLTRACCTVANLGSQQPTVRMAKALENLIKGELMQVKPSNSVDDMMHVYLNKIFLKTASLIAECSASIANLFRLDAIDCHKWYLIGLHVGMAFQIYDDMLDYSRGNVDLGKPTLKDLSSGLITMPLLMALPDSRELASLIADDAIHEGNLDAVLSAVRNGQAFERSHCAMMLHLLEASNLLRAIDVSGTAPGSALSAPIQNLLCFVHDTLTRSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC60</accession>
    <name>A0A061DC60_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0401090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769803.1">
        <property type="nucleotide sequence ID" value="XM_012914349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC60"/>
    <dbReference type="STRING" id="5866.A0A061DC60"/>
    <dbReference type="GeneID" id="24566158"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401090"/>
    <dbReference type="OMA" id="YYICISC"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596002" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="24813" checksum="FD80E42E31B8C765" modified="2014-09-03" version="1">MKGASGLALALAICSVGVSGFYFQIDYNDERCFYESVPYMAMLSVNYDLLNPEARSCVVRITDDERKVLQSTNLKELPAKGRVTYVAQVEGTYHVCIECPGQMWYVSHMAKIGLSTEIADGSDKYGRHTQYDVDKETTAKKDEIKVLSEDLSKFAANIMNIKSHQRMESATVKELHDTYKNMYSYILYFYILQFVIIGATAGFSVYHITKFFKAYRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC86</accession>
    <name>A0A061DC86_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0401490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769843.1">
        <property type="nucleotide sequence ID" value="XM_012914389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC86"/>
    <dbReference type="STRING" id="5866.A0A061DC86"/>
    <dbReference type="GeneID" id="24566198"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401490"/>
    <dbReference type="OMA" id="DSTGEWN"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="335" mass="41108" checksum="D2D2B21FCB3EFAFC" modified="2014-09-03" version="1">MDVVRELLNESCYYKLLDVEFDATYEEIRKKYRERALAFHPDKRPAEEKEECKNLFQKIQQAYECLSNDETRRWYDKNRHLILKSQRQHDTDDFDIWYYFGSCYSGYDESKRNNFFEVYRRCFSKIAELEMRELQYEPELELDEFPAFGTSQTDWKEVNKFYLFWQNFATIRSFMCNEMWQIEGRMHRRYFERKVKKEHSKLKKEFNESVRNLTNMVKNMDPRVIRFKQEQEELKAQMKLESIKLKEKLDEIKHVVKNEIINNMKQHIEEIEKQKEVLQQQDTCRVFASHYDNEQPQSEEQFFACQVCNKVFRSNNQLDNHLKSKQHLKNAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCB1</accession>
    <name>A0A061DCB1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767631.1">
        <property type="nucleotide sequence ID" value="XM_012912177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCB1"/>
    <dbReference type="STRING" id="5866.A0A061DCB1"/>
    <dbReference type="GeneID" id="24563986"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206030"/>
    <dbReference type="OMA" id="HRREHEY"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="334" mass="37641" checksum="31EB3DF778D72E4B" modified="2014-09-03" version="1">MILGRLSGRALFSFSGTDSSAFLQGLMTNDILLLDNAKKRLIACVFLGSDGRIQADGLVHRREHEYMVEIGTGNVETFTTLLKRRKLAAKVDYRQEQDGVVYGYTPREIVRRVSPATSETLHPTDVNLHVTQCTADLHLLNRQYTFNGLMHETPDLTMPHRLYLALNGFGLTLVKNLSSLKILPQDLALHKMGFIAKNKGCYVGQEIMNRIMNKTLMHKYRLHFILRRDHVDEPLDGHKNEAFCTDSAFYRTLSRNIGGLKATSILHRVVNEETTEQQIVTTDSKCIPLVYYSTGFGLALVPQRNMSKDTVIINDLEHVCLSVQPSTTYAPDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF2</accession>
    <name>A0A061DCF2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lipase maturation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0206780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipase maturation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767706.1">
        <property type="nucleotide sequence ID" value="XM_012912252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF2"/>
    <dbReference type="STRING" id="5866.A0A061DCF2"/>
    <dbReference type="GeneID" id="24564061"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206780"/>
    <dbReference type="OMA" id="PANDFWI"/>
    <dbReference type="OrthoDB" id="434126at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057433">
        <property type="entry name" value="LMF1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057434">
        <property type="entry name" value="LMF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="LIPASE MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463:SF10">
        <property type="entry name" value="LIPASE MATURATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25179">
        <property type="entry name" value="LMF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 N-terminal" evidence="9">
        <location>
            <begin position="169"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 C-terminal" evidence="10">
        <location>
            <begin position="562"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="784" mass="87090" checksum="11813120CB954B65" modified="2014-09-03" version="1">MALVRRDSADEPRVYSLGSGDVSPYTACNYEYPADQQADLLIARQEAESAKENSYNICRGIFLRALACVYFLSFLGHFNQDVGLIGQDGVWPAVVHMADLASSKRGVFLPDVSAFLPICDTCIRVIPIVGMALSLLVGVTGMASVALCLMLWFCKLALIALRSTLPTHNADLLLLEAGFIAIFLLSPFSLLEKPDKHWEVPMACRWAYRLLVYRIMFCSGLSKIRGSAHWADGTAFKYLLLDVPLPNPLTHLFFNLLDAQPLLNAFATNALLFVECVASIFLLVSARACRVVGGCVALNYALFMNCIGNFGTFYMLLGACTLFCFDDATLQTLWKNSFHKIWKLYKDDEGDEVAPVSPLQQVSDDVEEQSSDQEANETFGSKLVNAVTYRAKKKYIRDALFSNDSFGMTWTQEQHIYTQRIIQLVIVFITAIVAANIVIGRSNVGLKALLIFCLALIIHVQCDSIGTHEIYITAAGTLFALHMWLVLEFMTAGFSVWSFWLWIGVTELQLGLCHTKRKLYTMCSYILQSVIALVICCYAMPLLIRSAKYNSAVAGIKAPLGIVNSYDGFGVLPDQRYELVVQGTDEPVVTAATKWKQYELPCAPGDTTRMPLMVPGYTFELDNLIHDFASQGAHPEPTAVPRFMLELLRALLHNKPAATALFRSNPFQKGAPKFVRVMQYAYGFANSKEDGWYVRFPHTQLVPPLTLEHRTSHAEHAGAKHADKAHKSPAHVMQHLAASRHPATVLHVVHDMPPARNIRGVPLELADAFTQNTPPTDSLMLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCK2</accession>
    <name>A0A061DCK2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768945.1">
        <property type="nucleotide sequence ID" value="XM_012913491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCK2"/>
    <dbReference type="GeneID" id="24565300"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306630"/>
    <dbReference type="OMA" id="NMCATIT"/>
    <dbReference type="OrthoDB" id="365776at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="196" mass="21564" checksum="77B135D14113C178" modified="2014-09-03" version="1">MDNAEVVAEPTIGTMEWLDKNLKKMMIVLSSLSLLFCAALCGYTVYIFGYIADKTMYNLAVMMAVFVAALTLSDIVGLFAAALESEGFTALFTYNNMCATITTLVLSGVHFGKAVYIGKQFRAEDNLASTFFVTATGLITMAILHATMVFIGFRYKRLLSRRANVIELKLNDTVFTTINDLNQTQAISFPKTLNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCP0</accession>
    <name>A0A061DCP0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767876.1">
        <property type="nucleotide sequence ID" value="XM_012912422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCP0"/>
    <dbReference type="GeneID" id="24564231"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208440"/>
    <dbReference type="OMA" id="KMYDMFK"/>
    <dbReference type="OrthoDB" id="366027at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1205" mass="137009" checksum="4577890252D175BD" modified="2014-09-03" version="1">MILLPEDRSRYEYITRLSGDGTDDHVEQNGELSSASTEDYGNRKEDAVPNELRNANSTYPEAYSGGFERKQRNKEAVSTQTSANQPHSPRAAPVKSVNLDDMVEEAFKNQKPADHICIMRYTAGYRAEFLKELLGRLGEHKRKTKNAPHVLYVDRFPHNLKAIRESHKQEMDDFGKVNTISKRKISIAPNNLFTIAELVELSLVYHAINTYGEERAAELLEHLRNMRLHDKIVEYDLCEEEAFADEASAGTPENDAKAVTELSFKGAPVDETNQEEFAAVLRSLIESFFLSHDEVANRDWNYDGVFAPQKETLISARRLLQSTYHSAAQLADRLQINEPSKRIVILDGFAPRYFPTEATHGTALFDLVMTAMRKECQIAAMSYQLFNPQNVAQWMRRNIGPADFGVAAQFPECRVFKDDWHFNPFENGATPTYGIAEVNFLRKVLAENHLCPRTLFHKPIKDTTPSNWPINKQFEAMLKDILKQAMLINGIDTMHKLKHHSRGTYDYVKQYLPGGKGHRPAEKIGESGATVYGASDEAPQSTEQPDDTESMTIDDLLDQVIDLGRRHGAVKLMQKLNLNSAIQSMSNQVAKSVIDRVMKDGIYPTVIFARHADVEEYKPVLLENFEPIQEMENLVKEYALDSGDVEYLKRGVACLGRNVHPLTEDFVKRHLHMFKVVVTFLGLRGARHYVCQYPMDQRLNNIQTLRYPAPLLSTVLGAERLSFYGMPPSSTLNALSSLLSTIPTDYRWFVPLAALKHSMAHLPEAVMSNPKLASSFEKGTFAKFMMDCSDAYVDRNDGVFNAASDGTEKVNCCTELYRRRGNTSYTSALAKVPSHKWEENVLYYGSNGYRTSRKYANQSAENPEQRYHTHGQPRQPASRTRAQTQSPAYTADHVLRNRRPQSVPSMRSMLDRQVHLKSFEGRLTKLGVYMRPFYTLDQKWKRVAKFRSYLRNHIRGMLMHKGKAIHMLNTATSLHGADVLGMDDKHYTIMWVGTPARCTVPNHSLSERVWHAMRKLFEENSHHMYFAVLKAENGGYLCVPSMFIKDICEISNTVEPVRGAILLSRPAEIALSPKEGVPQDAMVDRLRYLVMTDKEGNEAEMLPSRMEAASFLPSATLELVRIGIETVERYKAVEERLTEDAVKKMLESPESGITTRDKALHMLRTTRSIYANRALGGLEQHLRQRQAQQRTWGRVPRSPADMLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCP7</accession>
    <name>A0A061DCP7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0307080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768990.1">
        <property type="nucleotide sequence ID" value="XM_012913536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCP7"/>
    <dbReference type="STRING" id="5866.A0A061DCP7"/>
    <dbReference type="GeneID" id="24565345"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307080"/>
    <dbReference type="OMA" id="YVACEHY"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="639"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="739"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="772"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="805"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="976" mass="108691" checksum="2FE0C659F3F443E9" modified="2014-09-03" version="1">MANERQGTEPEADPQEAGDRGTGVTNSPSASQDAAAQPLPDTDVTVDRQPSPSDADDAKMVGCPGTLLPLTTTMETNNVDCDSYYLSKSNSSELTSEMEGDNERDLDNMMEFHSAFIPSSSEPDTPVGNARDGVYEWYDVFARTKRHFLSNFGYDEKPQVRVDNSAGSGPRHAADSGLAKLVADRTAPRNALWKWAIPKLERFLDAHDVLMLRQTCVDLYRHKYTLRPHNELCFRGFVGYDMDVVIGFVIPLLAKVYGLTDGDKLGLDFSQCYNLKDISIVRMLSSQAVLNSSFDTQMICRNMRMLTLDYCHQITDKGLEVMLATKLPNLEKLSMVCCRNENITGAPFTTMLSEDRWPRLARFNCSFSNVTLEPIEAVANFIHRTTTAARAQEVSDELHKRLHADCTGYACNSRRWNDIGRMITRDGEAPASDGTAQPSPSHTAHPRWQLEITGCWGSRMFLDKHGFGAELHAFASAVKMKSIKICSKLTKRVQRGLQEMAERSPDDVALQLVMNRGSELLVNCPIVEHDRHNTMDMWTLPISITIQNDDMELCNLLIRRGARVNVWDYCGKSPLYKACEMGRTAFVKLFLKLGQAPMALDDNGFSPIAICVKSGNSAYVKLLLKAGVQLNLKCPHIRDFKSPLYIACEAMADDCIRLLLEGGADPNWLYHGRLSVTLLAYQHDKSWLPVFLKYGAGKPLNKRWILTDVLSCAIKNGNRESAAILVSQYPDLLERKHNVWSTPLVQAARLGEAAILQTLLDAGTDLKNSDMYETTPMHAAAEEGRLECLRLLVSNGADINARDIAGRTPLYLAVLENQARAVELLLSLGCDANAAEFSNDETPLMAALGTRNEDIALLIISKAKDLRLDAVDKLGRSASLYALYFEQIAVGEAILHQCAQLGICNSAVEIRLFNAVICDRIKARSANYKHLTRYAKHYRDVNAHVIRDNRIDFLFAQRWPLVKSLIGRIRGLAANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR7</accession>
    <name>A0A061DCR7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769030.1">
        <property type="nucleotide sequence ID" value="XM_012913576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR7"/>
    <dbReference type="GeneID" id="24565385"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307480"/>
    <dbReference type="OMA" id="HFIAMVI"/>
    <dbReference type="OrthoDB" id="363524at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="126" mass="14304" checksum="F3864B984FE7C74A" modified="2014-09-03" version="1">MSWRMFGYACCLMCGFNFVVFQFITAHLKGDPRHVELLPERIPTAHTACLACSIVHLIAMLVSLAYLRGYIKFDPFERPLRFIRSTVGLSPVSGPMRYRKMTENGTVVPESTHDADTDCSDSHYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCT1</accession>
    <name>A0A061DCT1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="5">dUTPase</shortName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0209040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767936.1">
        <property type="nucleotide sequence ID" value="XM_012912482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCT1"/>
    <dbReference type="STRING" id="5866.A0A061DCT1"/>
    <dbReference type="GeneID" id="24564291"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209040"/>
    <dbReference type="OMA" id="MHLKIMC"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="151" mass="16480" checksum="C522A319A9B5250A" modified="2014-09-03" version="1">MMHIKLLPMGADVSAMYADHKTFYPGDCGLDLFCPETVTVAPHTTHSVGLKIKIAAYRKNSPEDRDANSMKSVGWLLMPRSSIAKTPLRLANSVGVIDAAYRGEIVLALDNIRDEPYTIQKGDRLVQAVSYDGEEISYEVGGLHVPAECAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY7</accession>
    <name>A0A061DCY7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0308820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769165.1">
        <property type="nucleotide sequence ID" value="XM_012913711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565520"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308820"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="3960"/>
            <end position="3982"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="615"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3196"/>
            <end position="3219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1615"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1689"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2654"/>
            <end position="2681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3196"/>
            <end position="3208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="4034" mass="453800" checksum="4B01A6309C6A42AF" modified="2014-09-03" version="1">MESSQEVQLSSQIDEDGDLMVIDVDVPDGMDIDAPLATVGRRECRQPERRHESRKPVQSGVQGPKGKPTNSKGAGRGGESRPIPQASRKRHQPGTTPAVKGAGNKARNGGPQGQKGNNRKAKKTGNTAQTPPVVVCNAGPSSSERAPVCVQTLSTLQPPAGEVVGNGGCRSPTVYSISSDDFMDVDEEEPEQVGPVRESNNSIAPGTASEVALTETAALPRAPEGHAPQAERAGNTPQMPPNYARLNAKLQFLHCVMRQIDGPWCHWVPDVYKAVVTKYQRMPRGGWKVLAEYANEHFEFHKTHKEVEQMARQVVAKAARSQPTDVGEIASLHDVDSYNALQEDFDRIMAQRLREPGVIRTVKNKRHTMDSLDFTAIRSLDLVVHNYVKHNPVTDMGMLAVLYQTAQDCYDKYSAKPSSSSGKKEAAERRIKELEEIGALLLKYKQKVPLEKEDRKRVYRQMDKYNMIADKPQELSYVISRTQEELQKEQDKLKNAKFKKELYNDNRMFELYTGHFYRTLENKQDADESAINEGMMIEYWAQMWVKPNAPHNGEGYLVERPPAENKAGFPTYEEFVTIVKKLRDWKSPGADGIYNYYIKWLTSLHRVIYRLVEEACQQGKVQDDWFYCGITYLLPKNKKPKSAAQYRPITCMSNLYKLTTRCATETLKREVDGRGLRSENQMGTRSNVQGAKEHALANIALNEKHKGKLLATWVDVMKAYDSIDHAYLARVIDNLNLPGWLSNFIKQTIKRWNIEIRWNKNTIMHKKVERGILQGDSLSPLLFVLCLDPLSRHLTRIFPKVELSVTGGRIFATNHFLYIDDLKFFAHEESTMRGMGREVEKFFNDIGLRINRDKSATNTEACASIAKQMEGPETYKYLGVTETSNSLTSDGMFDIILQEICRRTELLAASKLSGKNLSMAINQYALSVINYYIGVIPMDITHFDKIDLAVRRIINAKHGHKKWANTQRLYLPRKEMGRGLHSMVFRAEAMLLRLWLTLSADEVTSTRRAAIMQHFRDTYAHISHIKMHLEGRYGMEFGMEDTTDKSLRDLRVAQNKWLYNRMHVKSTHKVLYAKREDPKLDIEASSLYLTCGILTPEEEANVAEVQDRNLQWMSSSKKCTRCNNGKNVDHLATKCQKLLHLEYTKRHNEVAKRVHSVLGRQIGLPKEKIDAHKIESETQKTKEYNRPDIILADRRRNTITIVEIGITNQDNLVDTEKFKKQKYEDLIEDLKARQFNQQTKIRVIPYVMTWEGIVTKEHSKYRRDLGISDRMEAHIQRVVIQETHKIVMRDMKPKEDYDSVEDPQAQTGWMPAWMAPVTSGNGPAWIPQPVSAKEARNVIQGVADKAKQIYDQLNIDDDKQPITQGISQINATKSNILKVDAELQKVNTDLRKWRVAAQTVLEIAVNRAEHVHEKLDPTKNDESHLIGKNIKDIGDVKKELDIANEQLKTQVESLNKWIQDAEDIRAAAEAKAREAYDKLQVHEKLSENVQRIVDASKAINGVHMAVDAKHKELGTWREKAKEVIDGAVEKAQHVHDALKDNVDKKMGEIEQENNAIKSACESLESEVNHLGNWKDAASKVIDKAKAKCDEILKRVDINHKDNEGGKNGPVIFKQAKELQDKGTKLLQAAQDAKRKVEEKVKSALEAVKNMDTDIKRDLKVVKDEIMKGIKDVIEKLKVDKLGEKVKQDLQKLRESIEGLKGSNKLVNDKVEMLIEEHDKVKQKTQEIMSKMQQEMQKTFKEGIKNPLNQKVGDVEKAIEALYKTINPKDGVTRDDKNKFQPIFEHIKKDVTKIKGNGNQKGNESGLDGIVAKVKGLANAFHKNGNGFGERVDGWIGSILGINENQRKTQTDGMKAVTSWIRAYYGQVRDRENALKAVKEQIKKALGDQIKAGQEKSSSRDVKESVVENLTKVKEACEAFVDTLDKKLTNTEIEPFVQQIVTKIQGPSMDQRVSNENDDRKTTVRAALIALCSCVRQVASEVQFIGINMFGKKIDTIKQTVDELDTNLTNATKPTESSDANPDHGTAKAVDNAIEGVKDMVENTIKEKFESDVKTPVEEAAQGLEKAVKTFDEAAKKQVKAAAKGAIDKAANVISADAGTRKINLSKSMSNFHKTHNEVTNKLRPLLEKLLNDHIGRDEIPFVGKAEKVELSKNFEKYLKHISVGVLTGHPHGPLAEAIDKIEGDGMKELSIIHPRHIGNDKIDEQTFDDPFKEIQSQLEDITKLVSDTRTDMTGEPASYRNGIKNYLEDLKNAFGDGKLDGAGESLDNIKKAIGQLQREPFSTKPAEIGKAVKEIKLQVDELKKKLLNGTDPKGIIDTLKDLKDAGLESGKWNRNVGMTHIHKELEEQNKILPRQTKVIGEAMDSVIKDINNVLREVGMTLDHHIIPDGDVIFRLKQIEDMIGRGKYKYEGTLQGIHDMISGLRAKNFSVNPDKIGRSLKAVKARLKTLRGVLQGENDKHDGVISALNDLKTDGLGPGEWNKERNTKGLHAIENDLKIEESKLSWQPTLLNSGFESITNVLDELRKELKDVYGNPNNDVINNLEDLLSFGFNGAEWQRKNVGGLVKIKNDLQKQNAELPKETDKIKQAIDAIKEEMQNVLIRVGMKLNHTLMDDDVVDNLGALKLMISRGGRGGLQAIQKKINDLVTNAFRTNSEAIQGAKDEITEELKRLQNNLKGVKDNDVIETLKDLIDLGLGAGEWKKERNTKGLETIEMELKKQQSELSSQPGLIDVGVEKITKVLEEVRAALHDDKGNPKSDVIKRLEDLRENGLGDKANTWNGKNGLKKIRIDLKSHNEKLSEDGEEMEKAMDTVLMQIQGVLRNARMKLGHHIIPHDDIAWDLHRLQRKFGFDEIKDENNLQEVLNQIGELQSKTFTDTQYTIEKAKQQIANELKNLIGVLDTNISSTLTDLIGNGMGKDKTWQNDNKGLGFINGELERQQGILKKQPEDIETGVLVVTNELDELRNILDGRDSSTAQERGVMRNLEFLMKEIGDSDHAGLKKIRKALETLNTNTVPVVTANLRKLCGDIQDAAAYADWHVTQLEDPHVDGKLKGIEDGIDNLRLTDLADAITMCDEFLDKANEIEKNTIHALLKHVDGEVGEAIEGLTKEARTLYVDSVRETLELFAKKVNEDLDQLPSEINRDMYMGYKGFMNTMEGENSGNINRLKCVISKELKLLSAAFAGFFGEVNEYVRKETDRVHRERDEDRNPSLPPTEEPYTPKLKDVYDALTALLAYLRDNDSDAYKLTELVDRLTKALGNLVPADFKHPSTPLLDSIANGLSKFAGEFHNTYISTYSGQRCWEEQSHKYAKVLLSMVPMTHKTLTKLMMKCESEWKALHISKLTADDRDNALGNYLTRCGYRVSSSESEQDGELNNMFTGGGIYELLFTPIEDVAIEMMVEGQPVKNGINLVTIMSLLYNTVCHYFQVCHLHVPPNTRYPCTVRDMLSWLSGLQYTVVVDKLPDHCKALLNLRCQDGDIPNKDDPVMAKCIEGLPLTIAATCSHSTALLTVIQGNGHGFDLAAYPYSVDFSNNRAMLHYPANPAELLDMLRDIACRLCRVLYFLYSQCCRSTARVRGWRECTYGRQVQSHNWQCNTFGRDATTASATTTSATVTTAATTTTSTTTHGCPPTSPLQSFLSDSCHGLLPHTLTADNMAIHCANCTANQPGQHCLTPLGFWDLGFAASISGTGWDLAKRLGDMCRDADSCVFVLCRTLFLLCPAAPSSLADVFALYAQLLRKWDSHDRVKHRGGTYTDASNFISHLNTDGIDSLFPLWAQLHGSYENGNLTSAIASLANHDHRSHDALSTLFHDSTCQSPGGCAPYLQPLGLHAHHTYPQKHAGRYITWIMYLAWQLWELLYNLLHALGKIDCTASGCATCPCQPGTHGGKDTCYCPSIVQCAGPLPTLYRYGFTYRNSNLLVSDNRAIRCGDLNAQLKKALQSGHFTELFRQIDQLIWHIRMPFFYCFIALWTLVALYILHTSLYRMDILRIRSHLLTTKASHLIDVKALLIPSRKMLSLYDASNFDDDPNELLNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD80</accession>
    <name>A0A061DD80_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768221.1">
        <property type="nucleotide sequence ID" value="XM_012912767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD80"/>
    <dbReference type="STRING" id="5866.A0A061DD80"/>
    <dbReference type="GeneID" id="24564576"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211770"/>
    <dbReference type="OMA" id="FREPVCI"/>
    <dbReference type="OrthoDB" id="366079at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF5">
        <property type="entry name" value="OS03G0795500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="28"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="195" mass="21908" checksum="24DA531BC2E222B9" modified="2014-09-03" version="1">MVQSRAGPFNGRMLWRNELNRLFRQGRTGGCEPVNLAVVGRCIDYTTSTALNALDGYGKLSEVLVSTSPNTPPMVSDVDEQLILKVFFLDPVSIVSIQLCCDAPPDDLEASKPKTVRLYTNRTEFDFSESDSVIPQHEIVLNEVSVGEKQTLKGTKFDRVTSLQIFIVDNLEGKERTYLQRLILMGTVHRPYPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA3</accession>
    <name>A0A061DDA3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger C-x8-C-x5-C-x3-H type domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0311270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769410.1">
        <property type="nucleotide sequence ID" value="XM_012913956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDA3"/>
    <dbReference type="STRING" id="5866.A0A061DDA3"/>
    <dbReference type="GeneID" id="24565765"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311270"/>
    <dbReference type="OMA" id="LQKYIEC"/>
    <dbReference type="OrthoDB" id="430732at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045868">
        <property type="entry name" value="Znf_C3H13/40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38160">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38160:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="265" mass="30441" checksum="FA21CD1816311A3C" modified="2014-09-03" version="1">MSMSEHSEPTRDVRVISVEQFHKTKLCPHMNKPEGCLRSMRSHCPYAHSADELKEPPNLIKTAMCKLHLKGNCDKTSEECPYAHSFDELRHTDGFYKTFICKFWEKGYCKAGSMCRYAHGTQELRRVSSDVGHLRSRDIDAMDRMTSRVTSLGEHAVAHMDTTERNCTAPTSTSAYSFNRTLPSPLFVYPVYGDVTAYSTTPTASGIQQWVPSTESSIAKEQDEAFYLMHYYLQKYIECSSKQQSYLQQQRYQQQGYMAESFHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDC2</accession>
    <name>A0A061DDC2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-rRNA-processing protein TSR2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0311720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769455.1">
        <property type="nucleotide sequence ID" value="XM_012914001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDC2"/>
    <dbReference type="STRING" id="5866.A0A061DDC2"/>
    <dbReference type="GeneID" id="24565810"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311720"/>
    <dbReference type="OMA" id="MALENEW"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="176" mass="19425" checksum="515E6E3C82D50AAB" modified="2014-09-03" version="1">MNNAVEAFRTVCRKVMSCWTALNLAVDNGWGGDSSEQKREALITQLIDFCLSKKQLYTDEVEDLLFDKMQTLFNVDIEDQSEVEIARLLVQLHNTCSTGDLSFAVELNEKLTKCSTEHCKVKDEVVEASSGESDDDTEGEGQDGEDGQDAGAAKGAGAKPRPRKTEELEDGWTKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDC3</accession>
    <name>A0A061DDC3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768336.1">
        <property type="nucleotide sequence ID" value="XM_012912882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDC3"/>
    <dbReference type="STRING" id="5866.A0A061DDC3"/>
    <dbReference type="GeneID" id="24564691"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300550"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1269" mass="139178" checksum="836705591D0B696E" modified="2014-09-03" version="1">MAKITSKIPALNNLKQCLQFLEWLKNDEHMQGQVAEELARRLRIYYSKNSDAQNIKTALSRLLFQVSHFYDKLCKDAQPTNYMENTPSVVLFTLLACIPKLLSVVYFLQYHVDKRFVAVGGGDWADQTIGLVAMSTSGVSKIDTYLIDTSFVKYGVISGGFEKGELKEGKNGGYTYGGEMVDNLPKLLEELHTNFFSDVFVTSALTNAGSQASNTANALALLKTFCEIVDNDKDNKVENALDGYINEYGNCIDWEQLKPHCAILKKSLEKIFNAGILSNTGHSPAVDDLNKEKFAKRMTRWLKENLDRVGSSLKEIKANRYTGAGEYFNKHFFPYGFIFDERNLGTESNGSENLDQKWKGVIGMLGGYGGELDALVHILKGRKCDQTHGHHTSPQEADAEDQYDDVVELVEDGTLVDAASSGSPNQNNGQSEQKPEISQAPLGSDTPPEDGKGQGPSGSGDGGKSLQVSDPPAQQLVQPPAAAHTSSTSTPSPGHPSPGGHGPGGGTGAPGSNGDPGQLGPTGPVASASSHLPDAQGIQPPPPTLQSSAMSTPTPPASPAVSPKLPAQAAVLGAGSDSASLGTQNTVSPQAVRNQAAKVSTPRSAASGSLAPGSGRGQHLPELEVEVLKPKLIHSRGVYKPSADALFNYDIEKSRYGKGITPPKYPLTGPQTFGKPHSQSDLAYNRDKLREASGLSNALGLHDADVPFERFDFHESPNEGITSEAYIPQCREPWFVEPSSLTTISATRSPPPPSDHLPPPQTIREMLYWLVGLTQYSYIYIIEKHVKSILNEQNNDVLYPSQHSDAVEVIGDPSTLDASHVTAKVTEACHYAAVVIYRIEDKGISNAMSIPEFNAEYRNYYYSLDPAGLLCQLRDYVYACHHQLEFLKSQCSRDKSHGGWVTCQYGQSVSADSPLQAFLTDASNYNTYFYNPCDVCLKSRIRMGFRKGYFGKSPKDASYLYYLLSPTCSVDDDPLLTLSAYLNCLTRRTPRTTGELVSFFHHFGNELYLSHSKGPSNLGTALSTPHPNCPDWDHLGRHDLHAVRGIRGTDAFNTIHDNAHPRTLSTLVGCSGDRANCPQHCSPITYRAYSLYSPTFAHTYLIWAVYLPDRLWESLKKLRYDLEGHGNTKCASLHSCPYAMPLLYLHGFTPPEGTPQTSLKCSDVISKLEKIVNGQPIASLMTRMDDFLYKVRMPFIYTLIALWSAAALLLSYTILYRLDILYLCSHAIRSKASHLIDVKALLTNSRKMLSLYDADYFDDDPNDLIDQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDC9</accession>
    <name>A0A061DDC9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768351.1">
        <property type="nucleotide sequence ID" value="XM_012912897.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564706"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300700"/>
    <dbReference type="OrthoDB" id="10557750at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1624"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1686" mass="190261" checksum="949B2A51C7B56939" modified="2014-09-03" version="1">MAPKKLTDCPENLREAIDWLIQVRHGNDNGLDHLSKAVKKLIDEAIEKAYTTNVSALLKALDSAKSYKCCKDKVAQIEKLKELKSFENGPFNDLKTRCEIIKNCTKRHLDSSQQKAYEEIQSKLEQLKSLKESLTGLTDEEECKKLLTNLCDGVETFLGFDSNSKGYTGQGIVYSDLDRLCDAAMAFLHGVLGSVKDDNAVTTYDNYILDESKRLNKVLEKLQSQIGKGSAGLVESVTQVTEWLEGYEREVKLKSDKEKDLIINLENQVEEHKKFIEQEKDKGLTTQMEYWTKRAGWYLEKVSKANKVLESFDSKLRDKLRRPIDMLLQAVKRFQEEAANGDVQEISKLTDKKLSTLKEYLGDRFNARIQGIKTYLKRHIGDLHKRLMKLNAESLGLLKNAINDDLQEAFNTVQRLIRRIIGKYQSNIVEQIKAILNEAEALTSEIRIEKQKLNEAVSGLEDRMGKLKGLKNAMMVPNNLDEYDKSDDKNKWNLQTLIKALKEEINRKLASAIEDLWTDLQQGLLKAYGISGVANPELPGLQALLGSELKKLQNVGVWIHAGTVDKHDIGNHLEEVLINLKRASSNWAKIQPGKVGLEMLTAIINDIGSKTVEGGKIQLGALCNAAAISGVTHLQDEVTKVVDGPLTDNKTPLTQIKNALVSLQTKDELRLDTSANGGHSEVHKKSKDIHDKIQNFLTYNVGESDVVEGSVYKDLKELQESIDALGVKVINVGEKVSVVSNELTSCIKDSNQLLRVVPKATEILINKLRDELNENISESFYELRQQAEDLYTRRKQKEVAALKKSVKDQFTEIDKIMEADSILSVKGFLKILKQTIVSEVLNIKCSTRSTLDEGAKILNIGFASFFKELQRQGDLLILNSRIFMPLSDKLETLLNTLTYYNHSFRINLDNVRTDLTTINFSLYYSSAKTISTVIKRGLSEFAEQLGHAYVSRYSGKQFNGALLKDKDVKSGEKQTTPPEKELTPEGRNCAKVCLTIVKMVYCDLGRLTRKCKKDWKIFQIHRGAQKVKSEIPNPLGHFLERCGYRVSDSAASQNGHLRNQKDFTGQKVYDCLASNDYEHVYNTDEDFEYPLQKLYHCLQNYYVVGHYASSFAKKQPCSVFEMLCWMCGLQYNSVQSDLLHSISEMLEEPATPVGGDGDLVTFDLQSFYINTYPNKATCKQLDEVINHIMSKSASILTTVLGYGDEHTTYACDFYDNSLKLYYPKSGEECLDMLLDILRRMFAPLRFLFMQCRLDQSHYGWADCYYGKQVYPLNWQCKDHEAEEANCRLRSALQSYLSDCLVGCMPHQLSAIGCKATCITCPKGQPGMACLTPLGFRGFSGSNRKGEDISNVLGNLFSNPLVASLFALAPKAPSTLPEHYQFALSLVNDWRNPRSHPIEDGITAAIDDRSISLYDNPSQLTNALRHAYGSSQASHDVDKHPKPIGAGQTEDKKYGDLCSLAMSIACSDQNSQCAPYLYALFADQYTYLASKQCKTYLSWAVYLPWTLWNYLNSLYNSFKDIYCQDWGCRSCLRADRCRRGQHGLVNDKTKAPNCHCSSIVECKGAMPTLYKYGFTFGAPAALNGQSGKKTCSNFMEQLNNVLQSTYFQTLFRECDNFLWKIREPFTWTVVALWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVGRLAKISYLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDG1</accession>
    <name>A0A061DDG1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768431.1">
        <property type="nucleotide sequence ID" value="XM_012912977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDG1"/>
    <dbReference type="STRING" id="5866.A0A061DDG1"/>
    <dbReference type="GeneID" id="24564786"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301490"/>
    <dbReference type="OMA" id="MINHILP"/>
    <dbReference type="OrthoDB" id="361012at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="661" mass="74192" checksum="68E7DF18FE7B4B82" modified="2014-09-03" version="1">MDNGIKKAKHFSCKRYREKRSFFLASMFMRALSEYHEVPTDDFIAYWALKTDSFAAFGDGAASSPSAAGNSGSSGAANAGEVDPGVKEKPNVKDFRYNSSEEKPSFKRIADTLTEYKLVSDSNRSDTTTPCMIRHDSSGDLLSETSREESDITSEAGSSAKDDVGVTQLKDNPRVKNSIFYDGDLTAFLQRQKLLYRVIEDLQTSLFVSKPSVDFVPQINLESIESEYIVVDRKFLGTRVPQQSASRPIRRPLGDEASVPSKRSCTQTNERRILSSSLSTLDRVLKKCAECIPDDRLAKSVHLQKLVNILGGKNPAEAYANEVLDGIHYVKSICAKTQVDFGPSAFYSPSLRHPIDCLSETGSKLSAVLDKNVFADNTLYSPQTAFMIPKNITIQLAKQKDEALNGSDEEGTSRLRVPRMSNSKLAHFVESLCGVDFDQKVIQDSLEQNSRECCDLRSLIQLCQRESEGEVEGGSETTAATTEYFSNTSTHVGHIDGFSTASVTYYKNRVLPTNAMEFYHNTTSCDYKKEGMVRMQGEGPLDVPLDTFATFDNRRQNLGHYLEAITALDVRIREIQRRSEKMHRALHQYSQQPHTDSVNDLQEVINLETLLFVCDTLMETKRRLHEELRRRVQEELDMINHILPEPLADSLTRILYPSMNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDL9</accession>
    <name>A0A061DDL9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">U2 splicing factor subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0400260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769720.1">
        <property type="nucleotide sequence ID" value="XM_012914266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDL9"/>
    <dbReference type="STRING" id="5866.A0A061DDL9"/>
    <dbReference type="GeneID" id="24566075"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400260"/>
    <dbReference type="OMA" id="MIDTRQA"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12287">
        <property type="entry name" value="RRM_U2AF35_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR97534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="239" mass="28059" checksum="872EDF52A86CC5BA" modified="2014-09-03" version="1">MAENLARIIGTEEDRVNCPFYWKIGACRHGDQCSRAHYKPSAAQTLVIRHMYQNPPVAIAIAEGQMISDELLDKAADHFEEFYEEVFLELMKYGEIEDMVVCDNIGDHIIGNVYVKYRDENSAAHAISMLSGRFYGGKPIQCEYTPVTDFREARCRQFVEGQCRRGGYCNFMHIKHVPRSVRRKLNERMYTEYPEYKRRSPRRSDGSASRDRPRRQSSQERRNMIEMWNREREAREAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDN3</accession>
    <name>A0A061DDN3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S1/P1 nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769750.1">
        <property type="nucleotide sequence ID" value="XM_012914296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDN3"/>
    <dbReference type="STRING" id="5866.A0A061DDN3"/>
    <dbReference type="GeneID" id="24566105"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400560"/>
    <dbReference type="OMA" id="HQPLRIA"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596057" evidence="2">
        <location>
            <begin position="26"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="396" mass="46045" checksum="157A60C633802EE2" modified="2014-09-03" version="1">MAKFILAPVLSLFGLYLLWIQRALAWNDLCREAIESTAMSAITMERLRRLKVILRGHDLVDYTWWAGEVIKRIPESARLHKQPQKDNTCVTFDSTCPDGMCLIEGSKYFFAYLMKSGYSITPNPTKFELPQFRYPKNVTFTPADALKYLMVLLADMHYPFNLDLDEPYSVGKKKVDVSAYPMWESLSMEKVGHAQPTLEEFISLIFMPHYIQKNEDSWYGSWTNVEILGSRYKVEQESFNRNTWDNFEIWATETANLNCAMIINRNDYKDDPNRIILSDSLMERLGLLVRFQIVLAGARIAIVMNYILSHREIAYCEKTGLLIEKNPNDRWSMDDIWFGAAIVAFCGICAAGAYVLFLLFKSMYKRNIKTHVDQALQGWKDRRKKKYTPHLDLHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDR8</accession>
    <name>A0A061DDR8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769825.1">
        <property type="nucleotide sequence ID" value="XM_012914371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDR8"/>
    <dbReference type="GeneID" id="24566180"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401310"/>
    <dbReference type="OrthoDB" id="365590at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="326" mass="36243" checksum="8560F63275957BB9" modified="2014-09-03" version="1">MEQSYDSTTTLQQFQLLQETQAQIEVLNTQINKINKRIGGLQVGQKRCEAALESLENTQPGQRVYKQVSRVLILRDPSELQAEITSERESAAKDLPKLTAVKAQLVAKLGGQSSVSRREPSVACSGATFGDLGGDSIMLHILLVLCVITCICDLFGAGLRRVSALLQALEERRAAANPAMFNSEGQVPTMTDIAMRFIASKLNIYKILRMIVGLIGVLSNIILPYYLLSRFTKTTNASYHRQTYSYMPFMIVDFERVPVSEIDLAEVPTSGAKKPEDINVLTSFNRYIAFMVSRVAMKAIYSTFYAACNPAGYLEQMMQRDKETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDY7</accession>
    <name>A0A061DDY7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768891.1">
        <property type="nucleotide sequence ID" value="XM_012913437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDY7"/>
    <dbReference type="STRING" id="5866.A0A061DDY7"/>
    <dbReference type="GeneID" id="24565246"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306090"/>
    <dbReference type="OMA" id="ADCKSSY"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="391" mass="43869" checksum="C4C810CE563DE82B" modified="2014-09-03" version="1">MTDNTVEIASQGNERPDWLVYPADSYRFREDSAPIGRGLLFKSSDEIVRKRIRAYNQKGLRITVCGVILCHRNGFPHIMLLTDSEGSCGLLGGKCRVFENPKEALRRKVARFISVARKGALQLDLRANAENVNVGEFLGEFWRQDYDSEVLPYLPIHVNRPRERILIYQVTLRDHCSIVAPSGLQIIPVPLHDFYLPEQGVAISALPHLLARFNMRLLGLQKVYTRIPVCTTLKPESVTMNTICLSSCGNGPDDTTLVCSPQAETWKTRLAVDAKSDFSLTDDCLDGKKRYKCLPYESSEIQCMDAAFATYPVGFSCFTSCGELKCPSDDFMKPSVSDDFKLADCKSSYRVRCRIHPNNENQQINVPDLTMELQLGGRSYLGKALRPAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE77</accession>
    <name>A0A061DE77_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0405280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770230.1">
        <property type="nucleotide sequence ID" value="XM_012914776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE77"/>
    <dbReference type="STRING" id="5866.A0A061DE77"/>
    <dbReference type="GeneID" id="24566585"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405280"/>
    <dbReference type="OMA" id="FDFCLHL"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="904"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="937"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR98044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130951" checksum="8EC3C3EE8F532A64" modified="2014-09-03" version="1">MVKAKHGSNPPTGVDVEGVLRDFADRKLSEERGCTVESLQKRRAEAFKNAAEDERLYKVFASCFMERRMWREALTELHTRLYLLDKESKEYEATMDMIRVAQHNLLAEVMPIPVAFKELLFVRDLEEKWSTWMSQVGYTEQLTNVTRAENAMEYRSNTLVTRVNLKPGSLLMRKRPFAAAPWCSDTADWQSSTDADARRISCFHCLSVMRHVTDPDYQSMTFVSCPLRPFECLKVFCSEDCFLHNGAVHAAECEHLMKLKSFATTALNETFVMLTARTLIRCGLCAGKRNSESSRPASGAPTDARGDVLQQILDVKVDYATLEQRYLHILDKLQMFADFLLKEMGVKFCLYLTRRELVHMMVVLWTKSVSLKPDVYSDDENVIIGGVVFDADMMCFQQSRLPTLVAHLDGVGRVSIRSIYTMEPGMKLFISTAMDKYVPFFIQDSEFWSAGLLLSEAVENCLPKKSPDISAVRCGQCIRGFCHIDALKSPVDGQADERSPKEYSWACSNRCATNDEDLNQIENRAESIIMRAHRLYVVGQHLVVRKLLDNFVWRWSGALHPKHYLLYNAHVLLAGIKMNKAGSNALEAVRHLTAATIMAEEMLPLVCHEKAHLYSRLADLMGQLVMTARVNRKEDVQLKQMTLEAAYTALWNWTVIAGAESREALIHMQKCRNIAFQMNVHVSKLCNNFVIHVPGKYMEIFKQVTGNCVLPPVFRFSAAGDLSETTTDHVATIAFMAAQSEILNEEVLEMLMSMASYGIMHLGTGLSVLGIAASNGSVEMVKAITESIHTRIDKAYDFISKNGSTSSVESTIANLLLTLAGGNELGVTPLIAMVSMPTASDPQSLKNEIIICRLIVECAEKCDEIIERHRGAVAVQLRSLRWLMESKCTVKSLVLDARTHNFLQGQTLLHYAAARGKRNLVQYLARLSGNVNQMNLEGATPLHLAAMGAHIEVCETLLSFGAKQNVAMNTGELPIHLAVHALHEDTVKLLQEQHAKNNGNMDAASNSACLGRRRKRGPSIWHALVSGIYRPEASAKMAGDIRLDVMVSRLERAARIAQFLAEHTPPQEMYVWSDMTPSQLLRQKWEEYTEGNSHLFDAQEGAPILHKADVDAYQPATTPCSVYNEGTDTIFVAERAMQFLAQLLKRAEEGSAEAANQRTDNGAPPTPANGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE85</accession>
    <name>A0A061DE85_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0308240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769106.1">
        <property type="nucleotide sequence ID" value="XM_012913652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE85"/>
    <dbReference type="STRING" id="5866.A0A061DE85"/>
    <dbReference type="GeneID" id="24565461"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308240"/>
    <dbReference type="OMA" id="KDYYVCE"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="11">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="12">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="423" mass="47704" checksum="DA552E8DA9115F6E" modified="2014-09-03" version="1">MDEVSQAESAPNALMRMPGEPITVEEDRDKVLTKVRQLLGWKHQSFPGAQPVSLTRNDLPLLFRSDYVVCEKTDGIRALLLAASGAIYLIGRNEEVHYVPIRLPVRGNPSETQQLTLLDGEIVLDTMQVDGVEVQHPRFMCYDGVYVQRRSLREMNFLDRLSIVYTDVILPYQKSLKAPAAAAADGAPVGAAQPPLAIYLKDFFDISQIAHIEQFSQSLPHVSDGLIFTPVRLQYLPGTCPKLLKWKPPHLNTVDFSVDVLYDERRCPRLVELFVMVRGTRVFYNEYLAPYGDVYRHILTMAIGSKITQLIVECSWITDSRVWTFVPKVRARGDVTHGGTLNDGKADYDFDNGTWVQGGWYAERIRVDKKLPNSLAVVDSVKSSIEDDITFEMLLQEFALFEKNGKIPLYNKCIMPKAYSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA3</accession>
    <name>A0A061DEA3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0308730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769156.1">
        <property type="nucleotide sequence ID" value="XM_012913702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA3"/>
    <dbReference type="STRING" id="5866.A0A061DEA3"/>
    <dbReference type="GeneID" id="24565511"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308730"/>
    <dbReference type="OMA" id="THKPNGH"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="3">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="488" mass="53090" checksum="88B9804ACB79E723" modified="2014-09-03" version="1">MAIESFIGSRISITTNSDLRYEGLLFDLNSEDAVIVLQNVQCMGTENRTSNVIPPSNRIHDYMVFKGEDIKDLGVCELKKEHPPEYGTFNDPAIQGIYFNNHFGQPGGPGPGPMYGPRDGPGGQGFGVMPPPPPPPMMGGPMMHPMGSPMYMPPGRGMYMGPPNMPGPMMMPPMGRPMGAPPMHDGSFGGPECRQPPSSPYWHEPGSFYGGMPTGMPHRDIMHPGSADKRLPGPMFMDSSPPHQPEADSGRFDLGEFDFGPDPFAEGDALGREESNSPAPLPDSGRPDPLDVEKREEELPTSEPHQLMTPTKREHKGPPSVKNFNIIKAEQLLASLGAADVKEDVGPSQTKPNALVADVKQGKPEKAAAVAPKEEKDLRPFYDKKSSFFDNLSSDIHGDKKMLRKERQKQHEINVDTFGADSVRRTQNNRGRGRGDRRGGGERKRRDSWNNERGERGNANKGSSGAKASEKAKAPEADVPAPAPAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEG1</accession>
    <name>A0A061DEG1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARCHEASE, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0311230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769406.1">
        <property type="nucleotide sequence ID" value="XM_012913952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEG1"/>
    <dbReference type="STRING" id="5866.A0A061DEG1"/>
    <dbReference type="GeneID" id="24565761"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311230"/>
    <dbReference type="OMA" id="HTQGTEI"/>
    <dbReference type="OrthoDB" id="2190767at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="entry name" value="Archease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682:SF11">
        <property type="entry name" value="PROTEIN ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="MTH1598-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="6">
        <location>
            <begin position="63"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="26473" checksum="B71407A9446091FE" modified="2014-09-03" version="1">MEASNTYVIDGVEITSKPPRARRKADVSRGRRHELEEPPSPPDSPEVDIAAEVEELASESHEFGYLDHPADVIITGSGKHFCRALESIILAMFGYITDTSLVDARSRRSISATGKSLNQLLFHVLVECLYMHNGHGFVARYVRVEGDVDVLRLLGGDTSAEVTVSLYGDIYDRKLHTCGTEIKAITYHGLKTQMTVGDQAVTLTDDPAEGTSPDAISHFLRSIDADSLKTAEFKLFAHVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEG9</accession>
    <name>A0A061DEG9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769446.1">
        <property type="nucleotide sequence ID" value="XM_012913992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEG9"/>
    <dbReference type="GeneID" id="24565801"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311630"/>
    <dbReference type="OMA" id="FPIEKWM"/>
    <dbReference type="OrthoDB" id="366067at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="529" mass="57536" checksum="F6555BAA41253951" modified="2014-09-03" version="1">MVPFSYLRRAKGSGVLRRLLELDDSVLPQTIKFVAAKALKDRNIPPQAVHSHLSGGTSAKCAAREPAARDYGRDVAALIQEKVAHTSAEQWTPSAIITVVYYLSESGVRLEAATRELFVRKVADAENLNIIDLWQALTAASRSRLDIPVGRLKRHLESNAETLLRPSRCRNVYSALRAFSTCGEALDPLTLQQIASHYLNKMSAAVDFKDASNFANALAAQASILWARRKNESMDGGGRAAHVGAALADAIDGVIDHTLMRANDSDADVEGIADTFDAVVQTMQWTKFSDETYARRVAQMQHLVSGINSRIGAVGVSAVASSGHESRGNPKAAQRAEPRVLRVVLRCLVRAGIHHPELIDKVLHLYRTQPQSWSAHGTAEVLSCAAFFGLRDTAVGDVAEHVSDHCLRNLLRHVPPSRILVDACVSAAQAVDESCRVRLHRLAAKALAHVDSIDERDLALAMLTLQLSPGAFESMPLSTIGQVAKRLRRRAVAIRVHTCTPKAPTFEAAESASAIFHAQFSETCEINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEI1</accession>
    <name>A0A061DEI1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769506.1">
        <property type="nucleotide sequence ID" value="XM_012914052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEI1"/>
    <dbReference type="GeneID" id="24565861"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312230"/>
    <dbReference type="OMA" id="PRYARWH"/>
    <dbReference type="OrthoDB" id="366125at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="201" mass="22604" checksum="F2101938A12C5A93" modified="2014-09-03" version="1">MSNQILKDYVRWHLEQVEASAPLGDCDGPPQLSEDISDMIESDSVSWCRSVDRCLAYTFESYCKLVLSTAMQRAHASHSNEVTAESVRQSVQALFRLPQQDIATPEVGDHHDVERCLCLYRGYATWYQRVGHRIYGVARQRMSNLSLHRLQSRAGAAYANQAHAARKATTRSAEAGLEGRYAYSAPQHKTAEIPLSQVFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN1</accession>
    <name>A0A061DEN1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769756.1">
        <property type="nucleotide sequence ID" value="XM_012914302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEN1"/>
    <dbReference type="GeneID" id="24566111"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400620"/>
    <dbReference type="OMA" id="HEAQIMW"/>
    <dbReference type="OrthoDB" id="360597at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="446" mass="50755" checksum="A7BA70FFA98599B6" modified="2014-09-03" version="1">MLTNGVQSNVLRSESSTVDAICRNVVYSITLLSKRQLLDLVDIDKCKDYTFLGEDVLASAGRGDHYCYKKVAPVLCETKYSPSKTVPNCEHIKSKFVSILNSCMQETDSDLSECNCSGINYETLTITDPLVFCKLSFVLQRDGVQISFKNNELDDCKSMADSYNHCQSIGKAFQHPKYCIDAVHDEAYNSLCRNIILPFIFSMMKDVDQNLSLNLCMNSDELVEKFVLAKRDALMASSQKLLDTMESDFAFKLWKVDMEQKVQNLKSDMQQVFKYFNAATRYTNRWFAFSYYFDPLVRSEASRALQLCEKMLMRANAISTDIESVTSFVKKIDPLFQLCEQVQQTLIHFKQFHTLATFRRISSLLNSVSEIVSQRVSTIGSLLDTHLNKLQNSDEESRVHALVGEMKSLAALHEAQIMWLIRGRGKQSSRAFTRSVGYQQTAKEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES5</accession>
    <name>A0A061DES5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769976.1">
        <property type="nucleotide sequence ID" value="XM_012914522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES5"/>
    <dbReference type="STRING" id="5866.A0A061DES5"/>
    <dbReference type="GeneID" id="24566331"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402780"/>
    <dbReference type="OMA" id="RTDFYCW"/>
    <dbReference type="OrthoDB" id="360790at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40755" checksum="124A81A77589564C" modified="2014-09-03" version="1">MPKTKDGKTWQWTQAEASEFFSYARGSFDAGDRLALDKKLRCAAEDAVTQQRCPSDIQKGFKRHEGGVDRFHSHPAADDIIGECVDELWSSDEKLAAVVADALENAATTYERVKQKGINEGLKVTKEVDVQLIQTAWKQAFTMSLSKFAMLDIQKWCASRAADGGLCALSEEDYMDFTGNTIHSIVNEGLGIVAGYAAVDRSAIRRELMFMQYNGLFTKNKEVITPYRGCATLWVKAEDLSPEHHKETLKVIEKIKRVPFELCKRCKIMLQIISHVRLVLMNGTDAEIRLHEDSLNNGVMFTILYIASIDSNEDVHIGIEVSGARKDVKLETDMLIVLRSNVPYEVKPVNGTVFIVNAWVTGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-04-14" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B9X1R1</accession>
    <name>B9X1R1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein Rab11A, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Small GTP binding protein Rab11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Rab11</name>
        <name evidence="9" type="ORF">BBBOND_0401630</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>Babesia bigemina : molecular cloning and charactrization of Rab6 and Rab11 homologues.</title>
            <authorList>
                <person name="AbouLaila M."/>
                <person name="Yokoyama N."/>
                <person name="Igarashi I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="AB482179">
        <property type="protein sequence ID" value="BAH23088.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769857.1">
        <property type="nucleotide sequence ID" value="XM_012914403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B9X1R1"/>
    <dbReference type="STRING" id="5866.B9X1R1"/>
    <dbReference type="GeneID" id="24566212"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401630"/>
    <dbReference type="OMA" id="ITAIYQM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAH23088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="211" mass="23206" checksum="5FBC6D6994D8C002" modified="2009-04-14" version="1">MVADQNYDYLFKIVLIGDSNVGKSNLLDRFVKGNFKLDSKSTIGVEFATKNVTLNNGKIAKAQIWDTAGQERYRAITSAYYRGAMGAIIVYDIACKASFSSVSKWLTELHDYADANITICLVGNKSDLTHLREVAKEDGEAFANENDLIFFETSCLNSENVDVAFKELLSKISDKNTRFDDGGASLTDAQMPKNTVVLGVKGGKRKKGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYR0</accession>
    <name>A0A061CYR0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="4">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="4"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765947.1">
        <property type="nucleotide sequence ID" value="XM_012910493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYR0"/>
    <dbReference type="STRING" id="5866.A0A061CYR0"/>
    <dbReference type="GeneID" id="24562302"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100900"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000122">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="242" mass="27756" checksum="7B9AB21BA7F24F32" modified="2014-09-03" version="1">MGDVLRNLSVILATYNEKDNIPYMVFLLIDVLRRQNIAYEILLVDDNSPDGTADVYRELQALYPSVSLKLLSRPGKLGLGSAYMEGLRHTKYDFVLILDADMSHHPKYIVDMIRLQRTGNYDIVSGTRYARGGGASGWCFRRVFISKTANFLAQFMLKPKMTDLTGSFRLYRRSLFESVLKDVKGRGYIFQMEIAIRAEKQYKARVAEVPIIFVERLYGVSKLGVMEIFGYLTGLFKLFWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYY8</accession>
    <name>A0A061CYY8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766012.1">
        <property type="nucleotide sequence ID" value="XM_012910558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYY8"/>
    <dbReference type="GeneID" id="24562367"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101550"/>
    <dbReference type="OMA" id="YSICKIH"/>
    <dbReference type="OrthoDB" id="359910at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="369" mass="41539" checksum="CE8D3E16F3B5756E" modified="2014-09-03" version="1">MIPPVESMPNNVMKSAKKLRNFFGVPEAQICRGCIKRVRCRRYQQVERDLPDLSDVTAVLIGVYSICKIYMQGSDLVVPQSSLKEISSVSSVMDALLHYLRASPQRIDYEQLGGEKAERLVQKHAKFKEAKRLEILKQKVFNMPAGFGAMPSAKTYMASFQRDLYNKLNKINTKGKEDDSLWVEDHGDTTLDCDRGEDFLEGLHKLNAVKNSLTRVLQSPDVTQPEKIHQLHPQCTNFRMNYETPIGTDVDLLRYDMVSDKFIEGIKVNAKGRVVVDLDSHVPAIGSDDTDLTPGIESYRAVTARKAGNYLSLMNKIRSHAVGLPFLKKVQYNYQCQSSGSKDSLGRVSDQEEREALSELAIALHSHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZI1</accession>
    <name>A0A061CZI1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0103500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766222.1">
        <property type="nucleotide sequence ID" value="XM_012910768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZI1"/>
    <dbReference type="GeneID" id="24562577"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103500"/>
    <dbReference type="OMA" id="DMVDYQG"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="3">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28303" checksum="967B84636D157FDF" modified="2014-09-03" version="1">MAREHVKSTLAAMASRNTKAANRAKAAMKAFRTAVTKILVEAEEEDALKSKSEIIAGAIKDRKSDATRILTNLHEYYEELSSMNESTALYDSLLKELMEYLDKLDALQSRMSQGTVEIPVPESARDTDHEPSTAACGSLQVEQETLPVRFTHPVESRMIEERSQQIQQLRSNIYDIQDLYVQIGDVVEYQGDQLDNIESNMAHAFEDTLETNIALNHTAERRRSSWWPNYALYILAFALVVIVLLYRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZM0</accession>
    <name>A0A061CZM0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0101720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766029.1">
        <property type="nucleotide sequence ID" value="XM_012910575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZM0"/>
    <dbReference type="STRING" id="5866.A0A061CZM0"/>
    <dbReference type="GeneID" id="24562384"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101720"/>
    <dbReference type="OMA" id="WNKHARE"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A OB" evidence="12">
        <location>
            <begin position="316"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="11">
        <location>
            <begin position="478"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR93843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="635" mass="70578" checksum="C0347914F3932CE9" modified="2014-09-03" version="1">MSLPRCLTADFFSSLADSVAKAGDGFFQEVHDCCSAVKILCLQQSCVAENKYLVEVLDGSVPVKYKHTCLALVPPTADGDKQLVGKVISFNQYKITPTKSRYLIILTKITIVPGDYRHLTCQLGPALVYHPGLSIQQAGQTPTSAMQPQGGVGTASGPIRKHDESLAQRKAQGSPYPITSSKPVVKTADAGSSAQISISDLTIYTPKWIIRARVSHKSQIRKFNNQWGEGQLFSVDLCDADGEIRATFFGEAVTKWYYFLEEGQVYSFSGGQLKPANKKFNNLSHSCEISMDENAQIQLDQNDISIPVLRCTFTPINQIDSVEIGAIIDVIGIIVRAREIKLVQHKGSGSNIEKRDVMLCDNSGASIWLTLWSKKVQHFQNNELDGHPLVAFKGVKVGEWQGRRLDTQASTKITVDPVIAEAAEIRQWWTTTGCQLRFDAGRQGQEVHIEDIVSIRQITKAANQALQFKSLGDNGITFTTRGIVEVIKESTFSWPACLECHRKMVNDQGQWMCTRCSARSKPKHTYILSLKIADDTGHLWASAANTVGAEIMNWVPAEELLALFEGGEVNADGKNFMNVFEEARLSEFIFKVRVTSEKYMDELRIKYRIAKAFRVGKHMDAAITCRMKDINELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZN5</accession>
    <name>A0A061CZN5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0103960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Tetramer of two alpha (regulatory) and two beta (catalytic) chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766272.1">
        <property type="nucleotide sequence ID" value="XM_012910818.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061CZN5"/>
    <dbReference type="GeneID" id="24562627"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103960"/>
    <dbReference type="OMA" id="FMAHYLG"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.480">
        <property type="entry name" value="Phosphofructokinase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01980">
        <property type="entry name" value="Phosphofructokinase_II_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011183">
        <property type="entry name" value="PfpB_PPi_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02477">
        <property type="entry name" value="PFKA_PPi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005482">
        <property type="entry name" value="PRK07085.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43650">
        <property type="entry name" value="PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43650:SF1">
        <property type="entry name" value="PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE SUBUNIT BETA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="11">
        <location>
            <begin position="201"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="11">
        <location>
            <begin position="781"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="343"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="390"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="553"/>
            <end position="556"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1347" mass="149734" checksum="018B14F69F890059" modified="2014-09-03" version="1">MSQERLFGSSVGHSRSRLFSSDAPDVLGLESGCASPKNVASVECMQYTNRDDAVERRRSRFHITPRATAIRRSANSRGGMQSAPMKQHNTVDFACNVGNELSEGWLPAPWCHAFPGDELKRINSCYTSKSCCQWQYTNRDIELPKLLQFDFHLLEEHESSGEDLRDFEELSGVLGHIAGNKMVSVQPQVLCSATSTHPTMKIGMVLSGGPAPGGHNVIAGVFDYLYLRNTQSQLIGFHGGLDGFLNRQHEIVSYDLMEKFRNMGGFNMLLSGRGKVTGMADLDRAVEAVNDLDLDGLIIVGGDGSNSNAALLANHFAWRQSADIDDGHPVLRKPCCVVGVPKTVDGDVQSHNIEVSFGFDTAARTYSELIGNLCTDASSTQYTYHFIRVMGRSASHLALECGMQTHPNVVLIGEEVRRKQQSLSSIVDDIVNLMEKRYHMGKPYGVVLIPEGLIEFIPEINVLITELNEIILKSEGPVTHLAPERLTKSRATWEALPDNIREQLLMDREATGYVMLAKIATERLLLMLVEARIAQRKLEHLASLTFMTHYFGYEGRCAMPSDFDGAYCYSLGYNAGVLINAQRNGYMSVIRDLKSPISDWTPLGVPFLHLMQMIDLGGRRVPAIRKTLLNLDGNLFKVFEKVRDTWAYEDLYRSPGPIQLFDSDSERCFCIADPTVEDLVGKPKSAADSKSRFLLQRHIDCMSPLQRNRLGVRPPIPTLCSDKRARMKMFKQVLSNDPYTRNQVALNYPYMIRRCHFNLYEVVSQYPEVELNQEDVNVPMKVGVVVLTKQAPGVLNVIWGLYERLALRGSSCVAFNGARGLVEGDYIELSAGDFDLFRNQGGLELVHRSRVHYFHDPENWGLALKTCTSLGLDGLVILGDESAMTQAALLTEYFLSKNSNICVVGVPVAGSNGLAGPLIESCVGFDSNAQLYAALVGNVLTDAVSMPKYWHFVKILGRYPSLEVLECALQTHPNFIIIAEEYGSADKTLFDVVRDIADAVCKRAVMGKNYGTVLIPDHLVLHLPNTKSMLTELRAVLMEATAAGKRREAVDSFLNYSKGNDNGNEWVHKMTPWSLGVFTSLPTYIRSELLNFDTEVALERLDIEIMLAKMVKEELNVRKAKGEYRGNYAAVTHYFGYQGRCCMPSEFDCSLAFAYGHLAAISVESRLTGVCCSIRGLCGTVKDWKLFAVPLTSLMKVEPNILTALSLNSYKKGELPIIPSSTVSLKSKAFKKLTMARKKWLFDDLFSNPGPIQFNGSVTPQSLVLLTEHAEYYQMLRGVERFVHVLQNTCKFGVSEEYLNHAFVQLWGLLRVNQAPGDLVGLADTIKSDDDLPPTTSVTPSSLNSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZT5</accession>
    <name>A0A061CZT5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0104350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766312.1">
        <property type="nucleotide sequence ID" value="XM_012910858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZT5"/>
    <dbReference type="STRING" id="5866.A0A061CZT5"/>
    <dbReference type="GeneID" id="24562667"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104350"/>
    <dbReference type="OMA" id="CTTHFWG"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="96" mass="11005" checksum="6E725511C3C8E5E6" modified="2014-09-03" version="1">MAPAAGRYFLTTHFWGPVANWGFVVAGLSEMRKDPERISGRMTGVLCFYSMLFMRFAIAVKPRNMLLFSCHLCNSTVQAAQLYRLYEYKKAKAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZT8</accession>
    <name>A0A061CZT8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0102560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766114.1">
        <property type="nucleotide sequence ID" value="XM_012910660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZT8"/>
    <dbReference type="STRING" id="5866.A0A061CZT8"/>
    <dbReference type="GeneID" id="24562469"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102560"/>
    <dbReference type="OMA" id="QCYQHVS"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="5">
        <location>
            <begin position="484"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="675" mass="76918" checksum="9FCB4018E2F96D00" modified="2014-09-03" version="1">MSVTSKNSAAGRHEFLPENTPSYLVDGNPEFRKRARNTISQAVRKFIKDAQEQDGRHEICQEAVGRFLELMRLRFLDNAIPEHRIGGLIGLAAAAIALEEYLDDHADAFIHVALPYFTDQDSAVRYYACESLFNIFKKAPDAVTRNFSEIFDGVCKLCCDIDDDVRQTSELMSRLVKDIILQNGNHTVEMVVNLVASRMHVTNSFVRMLLWKRLTDIVDNSAQRGAEYVITNSRIHEDADVDMLEHLPKLYIGLLNMLVDSNKLVMMHVSCMGLRDVRGGAELCLAEFLSLFKKTFATKTNIVNEALFKAVLINTKRSEYIVKKNNIGWIRELACLQPQLIHFEGFPQLLRAVIMSIADQNADVSACAQEANKQLFMTAKEQRSVSNVKQITKELTEIVELPVTHVVMLTVLQWLTLLLELKPRVMKDALPVVTRAIVLCFKQSDSEPIMEATLKAIILVVELGEQNFELVSQHLLELFKSDDALLEERGNRIIINVCKQIGFEKFYKITAECLALYAEADFLRRIVHTLNWTLLTSEDARTMRKLLLTAEGESLGTLLQKCWEHNLSSALALALWREKYKLANEIVQQIADSNFDVEFWLWTDSLVQLFDTHVFMKMRLHLLKPTQHNDLLQALLGLSMLLPQSETNKQLMRRLSISQFAQIGEQLAMMNMRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0U0</accession>
    <name>A0A061D0U0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765933.1">
        <property type="nucleotide sequence ID" value="XM_012910479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0U0"/>
    <dbReference type="GeneID" id="24562288"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100760"/>
    <dbReference type="OMA" id="AGAHICK"/>
    <dbReference type="OrthoDB" id="366381at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="576" mass="62118" checksum="F279922E06FDAB00" modified="2014-09-03" version="1">MPSCTRIRQLLPRLRLLGRNVSLQPAASGKPATNASKELKRLLYKALEENALADETLVQAADCLYELKGCNTTAGAHICKAVEQRPHIYTRPLSGGVLWSFHAAGGRSTKRKRVVKSSCVAAIEAFMNELFAIQNDSRNASHLTSTLSNLAIVGQCFSLPVSTRARLEQAILDARDSLVPILERSNAVVAYIEVLYRFRIRSDPIAEDALNAFVAVASYHEIISTSALAKTIKILQAWRIGPLGANRSALDMLTHKLNKVPVLLGKNPNALVKLYLASTRVAPATCDIRESDRVPSDNGGASNDNESEATICVQNATESDNHTGLNGSALSGAVKGAPTDECHKDLETEQTAADKLHTSQYNHSTTNQSSVENAISTDGRPTQSASFDAVATSGVQCLSALLLRHCCNLVTRCNARLLVVLYNAMCHHILRDVPIMKYDAGHPSTADERSVSDKGANSAANAPSKHRADSIMSTGSHLLMDIVTGFSLSDFATCVHTISVEVRDALALDASAKHGAGQPPLTLYDEKDLTTIRRAALVASRICSGAPDEVARLAEELLRDRFGVAFVSELRDKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0V1</accession>
    <name>A0A061D0V1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765943.1">
        <property type="nucleotide sequence ID" value="XM_012910489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0V1"/>
    <dbReference type="STRING" id="5866.A0A061D0V1"/>
    <dbReference type="GeneID" id="24562298"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100860"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="OrthoDB" id="338608at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="667"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="709"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="751"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="332"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115085" checksum="068C724D85046D0B" modified="2014-09-03" version="1">MVKSYLRYALQDSFGTDFVLTGHDERVSVWNCRTGEARVNFEAKPDDLHAPSDVTAFVCSDGVERWLYVGYADGSIRRFQRPESLAGEAVSVVNEDFHVQGHKNAVTCLALSPFRQLLASGSQDCSIIIWDTTGDLGLFRLEGHRNEITDLRFVSHAGGSESQLKSRRLGAERASVKQGDDILGFLLSVSKDCIVRVWDLTSQLCIQTVIHSTAELYSIAVNSNESRFYVGGSENRIRCYKLDVSGSEKEENSAYDIPVYAKELPSLNRPENHGRCRRLCIMYPGAKDAAATYSGRKGSRASGKESAKVLEIDQKGLMLCVTTTFVVFYRLYDSAEAAKRRKRRQKRHLEKQRARCNKLREALRATGREVTVKFDSLEATISHLEKLLSGTNPVEPADPSASNAASSNTEFAATDELNYMFAVNAFERIASFALFSSGFVIGYANNRVSVWRVQLQKLLSPKTADDDSDMEDMVSLCERVHLLDAVGHPSPIMGLGVSPSDTMLLSFSAESLKVWNSHTLHAIRTFDCKAVACAYFVAGNRHILAGTSTGELRVLYLDTCDVHEVYKLAADTSKRSSDLDVISICEHPDHASFAAAFRDRCVRVFQYMLKKKGSQEVLCVKEVSSTSLADDPTEVRYSSDGRLLAVALHDSTVQTFYTDTMKPFLSLYGHKLPVTSIDISSDGTLLASSSLDKTIKIWGLDFGNIRRSLLGHSSAVVKCRWINNTHYLVTTSLDSSIKLWDCDTYELICQLRGHSTAVRSLAVSSDAHFFISASDDSTIRFWRRTDEQIFLSEEREKELELQLEHEVVRDDLNQAIPVDRDALLNKATRKTVQSVKATEDLMRVIDEAEEYRQALEDHKQQVRDYEEMTSGTGALSKYGTPDTAPPKEPDPPLELFNRTPTEHVMMAVCSLTHSVVHEVLIALPFIYAEKLLNYIVSSLESYSYLCGSGTVNLHTMEMASKTALLLVQIYFRQFFALSHQRPLIARLERLLPQALQHELDRIRRNKAALEHLKGLLDADVLSKRLRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D190</accession>
    <name>A0A061D190_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766053.1">
        <property type="nucleotide sequence ID" value="XM_012910599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D190"/>
    <dbReference type="GeneID" id="24562408"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101960"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="25052" checksum="DCC2809D5EA70A79" modified="2014-09-03" version="1">MLLKFLDQPELGNQWFVGGLVKRYNDLINKSPGGLAKYFRVVDESDENVVKGKGITAGAIVENLGKVVHGTEIFLDDIKSPGEYESAYSSEATWSKSCTQKPEDCAAVFVGIAPMLRASISSLNAAVFAAKLRLPPFIACKRMQQLIQALGYVEPQRRAGMSGFDVPKALRGLYLRTLITLCDFTGFWAFCGSNNPDLGAGKHGNYPVSEVDFDVNMKPIDASMKIGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1H9</accession>
    <name>A0A061D1H9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0107960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766684.1">
        <property type="nucleotide sequence ID" value="XM_012911230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1H9"/>
    <dbReference type="STRING" id="5866.A0A061D1H9"/>
    <dbReference type="GeneID" id="24563039"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107960"/>
    <dbReference type="OMA" id="MWELDIR"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="128"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="24107" checksum="D34ECDEA6F9531F7" modified="2014-09-03" version="1">MDGLWDLDVRNALSLITAAGDCAEQFSRKTDPGDRHTYGTIMRAKLDSLRKTIANLELTLRDMSSGTVPPADLDARREQLDGIKRSYQELEGVLSPAGNHASLPAAQPMTPKRQLDHMSREELYNYRNSMMRAQDNELEMLDSTAGAIHSISTHIKEEVDYHNDLLGDLENAMDTSHTLVSRNRAALAAMIERSSKGRLTFYIVVLTIILILVIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1W6</accession>
    <name>A0A061D1W6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0110635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766952.1">
        <property type="nucleotide sequence ID" value="XM_012911498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1W6"/>
    <dbReference type="STRING" id="5866.A0A061D1W6"/>
    <dbReference type="GeneID" id="24563307"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110635"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110635"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="5">
        <location>
            <begin position="125"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="27055" checksum="8FD0E36985DF5F2B" modified="2014-09-03" version="1">MPDFKVDLSKVASREGLVELNEYLADHSFVAGCKAPSTDDLAVFRKLGNSPGAAEFAHVDRWFRHVSTWAQNPPADLAKGSLPVEEKKADDIDLFGDDDEDEDDAMKKKMEAMKASKGKKREAAKSSLVIHIEPASVETDLDEVLRLVKNIKIEGVTWGEASAKIPLAYGIQKLQVSCTILDDIVNTNEITDLIEELGLTEAQKEERRMKQEGGADDESDYDSDADSDDEVVGLVQTANIVSFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1X0</accession>
    <name>A0A061D1X0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5'-3' exonuclease, N-terminal resolvase-like domain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0104310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766308.1">
        <property type="nucleotide sequence ID" value="XM_012910854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1X0"/>
    <dbReference type="STRING" id="5866.A0A061D1X0"/>
    <dbReference type="GeneID" id="24562663"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104310"/>
    <dbReference type="OMA" id="MGIGPKT"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646:SF2">
        <property type="entry name" value="5'-3' EXONUCLEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="FLAP ENDONUCLEASE XNI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' exonuclease" evidence="4">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="314" mass="35017" checksum="B32FD2E212522956" modified="2014-09-03" version="1">MNSLARIYRSFGPKYIGIAFDSPGSNSTKREVWPEYKANRQAIKTSFKKQLMWIKEFCSIVGLPIFLRRSTEADDIIASMITFLNGGAGKDDADQSGDEEVQQMRQIDFRVPNPAPGGVFDRVAGASAAQLERMDASTDNGLQKRSFDVHVLTADKDLLQVLQHNGAGNVNVRVVQPHKKFRLVDESTVLEEYGIPPGRFSEYLALVGDSADNIPGVMGIGPKTAPVLISKYGSFKEIIDSAEIAKIARRGGKHSLSVERAYDFHLITKLRGDVPVLSSLSQLRKKRTLERQFVAFCRMFSLQKCSLRWHDVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2E7</accession>
    <name>A0A061D2E7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase small subunit protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0200980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767127.1">
        <property type="nucleotide sequence ID" value="XM_012911673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2E7"/>
    <dbReference type="STRING" id="5866.A0A061D2E7"/>
    <dbReference type="GeneID" id="24563482"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200980"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="92" mass="10176" checksum="32934B20A5A58426" modified="2014-09-03" version="1">MDKVDTTSPNITFSIENEDHTLGNTLRTLLVEREDVVFAGYSVPHPMQPEVNIRIQTTVKVFGECLDELVEICDLLTDAFVEAGAESYSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2R5</accession>
    <name>A0A061D2R5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0106710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766548.1">
        <property type="nucleotide sequence ID" value="XM_012911094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2R5"/>
    <dbReference type="STRING" id="5866.A0A061D2R5"/>
    <dbReference type="GeneID" id="24562903"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106710"/>
    <dbReference type="OMA" id="IMCANIQ"/>
    <dbReference type="OrthoDB" id="381520at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26743" checksum="775070FD84071D44" modified="2014-09-03" version="1">MPLSSQQRAFTSQREGSIDEAEPAYRPQGPKDTLLMLGYAVKEDQIEAHVHALKEALKLKLMTLNYYSEDMAQSFTDLAMAQHQSVQFINEAKTNYLKALDIWTKLCGQESREVANVLCLIGVVLRDIGDIDAAKSALQDSLRIDKQIGSVESQLSSVFALNNLAGIEHIQGNMTEATELYEEAARIMLTATGGDPNHRMIALLYYNIGWSDAAEIIAKIGDAHHLTGRIDKLFKEVAMSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2V4</accession>
    <name>A0A061D2V4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartyl protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0107210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766598.1">
        <property type="nucleotide sequence ID" value="XM_012911144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2V4"/>
    <dbReference type="STRING" id="5866.A0A061D2V4"/>
    <dbReference type="GeneID" id="24562953"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107210"/>
    <dbReference type="OMA" id="MGFWTID"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="42"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="76"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="480" mass="52781" checksum="3E64921AFC661CF2" modified="2014-09-03" version="1">MLRSLLYEQLNNGAAQFVGVDAVTSSSIALTAAHSNRLWATYYGEIILGNVEDEGDTFKVLFDTGSSELWVPDELCESNACLTRKRLSRAERWTAKYDDRGNYIPILVKYLTGEMRAIDGTADVNLMNGIKVKDASVGLATKLDIPILMELPWDGIVGLGFTTDDQTARGARPILEAMQQNAVTYPHFRNQFAYYISKTGGNVTFGGYNNDYKRSPADEFQWAPVSNKGSYWAVNLLQLTVKENDRLNRHQFDSGDHNVAQSGTDPGDASMGDSTAVDANQPNDASGKLPLNVSDKQGATPKHRKTTIANTTMDAVNPTGNPADESGSVAGATASQANRAAESRPPLQYRNKLHDTKVIIDTGTYLIYAPQNMQNLVSSLFVDSCDAKRNLPTLVFTVEGTGFGGNSEIQLELTPDDYVLQFTDDDGETRCTLGIMVDDQQEELQLNAWTFGEVFLRAYYTVFDYDQRQIGFTPSRADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3E2</accession>
    <name>A0A061D3E2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0202700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767299.1">
        <property type="nucleotide sequence ID" value="XM_012911845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3E2"/>
    <dbReference type="STRING" id="5866.A0A061D3E2"/>
    <dbReference type="GeneID" id="24563654"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202700"/>
    <dbReference type="OMA" id="YHINTIP"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="12">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="13">
        <location>
            <begin position="540"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="817"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="934"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="940"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR95113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1027" mass="116945" checksum="F0965590443ED05B" modified="2014-09-03" version="1">MADTKRDVVINYDEVKLKLQQLNALFENPALSTASVIFICTGKTQGDASATPSELLQLWLTGFQFPETLFAFSRDGTWYILTSPKKAMYLEPIRQHHEKLVIMQRSPDKSDAEQVSGIFEKFTDPVLGVIDGAKPTGAFSDKCLEAVASFATVDVTFEITNMMCIRTKVELEAQKQAAQFACAVMKSQLINQIENILDSEAKKAHSKIVSEALNVHTDIKFLEKMQKKYNMNPAETEVIYSNVQSGNSFNLGIGVPPDESTLSHSPGAIIVSVCSKYSELCACITRTLLLDGTAKHKDAYAFALKAFDYALSKIKPGATFGSVYDEVHKYVVKEKPEFADNLLRSLGHTMGLEFKDAKFTLVSGNDKCTIASGMVFHVSLGFGHLVEGGKEFAVWIGDTVEVTPEGAVVLTANVSKSLENISYELEEEEEEQVETSASKPQKQPGVSSELLRDADSVILKERLRRRDRGGQNQVSEAEMKARLDRQLQLRKEKVAAIVERVKAEGGLAGTAKQRSVVKMDKMRSFSSPNSFSTDLVPRQIYVDVRNEVIMLPINGYHLPFSIMTVKNASCNSDDNQTYTLRINFQVPGSHTFSSKTEVNPLPDLNHENAIFVKEVLYRSSDSKHLQNVFRSIKELIKQVKQRETDADAHLVLAEQEKLQLNKTGRRIVLKDLMVRPNIHGARRIIGFLEAHHNGLRYVVNTRDRVDHIDISYSNVRHAIFQPCERELIVLLHFHLKSPIMVGKRKSIDVQFYCEVGTQIDDLDNRRGRSYNDPDEALEEMRDREMKRRLNADFKQFMTQLQEMSSLVFDMPYRELMFSGVPSKSNVVIFPTAHCLVNLVEWPPFVLTLDDVEIVSLERVQHGLRNFDMVLVNKDYSKPVRRIDLIPVEYLDTLKSWLNELDMVWYEGKNNLQWTNILRTILEDVDAFVENGAFDGFLGESEGEDESVDDEDEEYEHESDEEVEEDSEEEYSDEDESLADEDEEDDEEAYDEEEEEGLSWDEMEEFAKKEDDRHRYEDDSHHRRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3X5</accession>
    <name>A0A061D3X5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ulp1 protease family, C-terminal catalytic domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0204260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767454.1">
        <property type="nucleotide sequence ID" value="XM_012912000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3X5"/>
    <dbReference type="STRING" id="5866.A0A061D3X5"/>
    <dbReference type="GeneID" id="24563809"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204260"/>
    <dbReference type="OMA" id="RWLQDEH"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="204"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="420" mass="47694" checksum="DD854F61193C1AF9" modified="2014-09-03" version="1">MGKSRAESPTPDLVALSNAANALESNHTNINSDDGNDGHHESYGVGDTGEGLSSLSDSTKGAPESTGQHVTRGKDTALYDDVLREMTKLSLRDDTCDQENPICVTESHQSKSDRLLRKLRSVDDVQYGKIVEPLPVAGEPGFDLWDLKSRAKSYEQKRTHVESLFKNDSPERWLNLEKLGNADDTLSLLRRGSPCEVLADRFGIEMTRKHLRCLDGPRWLNDEVINFYIGLIQERNDRLTGDGVAGIPRCLCFNTFFFNLLCGGDDPTTTYNYSAVSRWTTRRKVDVFAIDLLLIPIHVHNSHWCLGVVDMRPRSRRIMVFDSLSGHHRLFFRNMSRWLQDEHLNKKKVPIEDIDEWKHNHIYAAEGGAPRQNNGHDCGVFLCLYAECISVGKPFDFSQNDIRDRRVMMIQQILRGSIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D423</accession>
    <name>A0A061D423_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765915.1">
        <property type="nucleotide sequence ID" value="XM_012910461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D423"/>
    <dbReference type="GeneID" id="24562270"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100580"/>
    <dbReference type="OMA" id="FCINCHY"/>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="525"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="600" mass="67460" checksum="95647823AE126824" modified="2014-09-03" version="1">MWRQLTPRIVWAARATCLDASSSLSLPQCTPLTNQQRRTRTAVANLYLERVQEYDVASFLRLVRTGVFDCGDDLRRVFSGFQRYLAHLKAEEFVEMLELFRSRDLRENEEGVDLPLLLICEMNRRMRGGQHRLFSLRQCRRICAALRHMKFNRPSHVTPSSDHPGPASYGAARIHQGTDEMGSAPSEHKDGHPHRIPISRRNGSESANSMHTTRDSHYTHTRAWNDGPPMFAEDTREVAVPVCECNVGQAALPRACAACCAKYGPLLHLPGYDQLSLLIVLLGRSIVLQLSGVRRLHENAVTGYLMLSSHINCTLNAHILRSIVAQHQAALLRSKSLRNIAIALHVAKKCKVRCGGFERRMRSRLADIGEFEALCAGERHPVALLVALSQLVGSLVTANALPTSREVRQIGINIITYLLDHYDKFFGADAELDADVVSSMRGNARLLVDYLASKGVNFERIFLNGDLERLEALTVCGAVDYSKDFRTSDFHRQVGSTLSLLGHAVEEEVRIGSHVCDIVLRKAGTVVEIDGPYHFNTALNERTNELLNRNGCDYRLTYTHNSNVKQFMLGLAGYRVVHVPFFRWPSGREEQLEYLRRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D438</accession>
    <name>A0A061D438_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767697.1">
        <property type="nucleotide sequence ID" value="XM_012912243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D438"/>
    <dbReference type="GeneID" id="24564052"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206690"/>
    <dbReference type="OMA" id="ITDIANF"/>
    <dbReference type="OrthoDB" id="361486at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056356">
        <property type="entry name" value="Microp_apicomplexa_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23531">
        <property type="entry name" value="Microp_apicomplexa_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="110" mass="13030" checksum="33A8E4223A410906" modified="2014-09-03" version="1">MLALTYRLMAAKRFVPMVPYGVKISRSYRESKRQQRIAMETARKQREMKGMLLDTRKTLLMSLRDNTGINWYRATQILKHLEVHRRHPSGATQAWRDKITKIAETVKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D471</accession>
    <name>A0A061D471_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GTP-binding protein engB, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0206990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767727.1">
        <property type="nucleotide sequence ID" value="XM_012912273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D471"/>
    <dbReference type="STRING" id="5866.A0A061D471"/>
    <dbReference type="GeneID" id="24564082"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206990"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF13">
        <property type="entry name" value="ENGB-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="11">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="555" mass="63032" checksum="C845AEF171B6C90F" modified="2014-09-03" version="1">MFYTSRFLLALQHVKQHVERTVPLSDSTLKEVIVKAIGKPTSSDELKYFKRNRRAKPVAPFFAGEIRPKLKLVAAAIDHSELPPPTLPEVAFYGRTNAGKSCLINAICGRYGVCPVKPLPGTTRKVHFYKVTLHFIRNMHAQVGSPPSIILVDMPGYGYSSAKEDLSMQWNEFALYYLKHRETLKLVIVLVDSRIGLKQSDLEVINFCSKYKIKWHIVLAKADTMKPVLLAKMMQKVKLETSTYRGCNGKIIAVGATKDQNLEEIRGVVESFKVDKHMAHFWSRYKASRTPYVARKVMLEDTPKTIAITTGNEGDTCLINESSLHHETAPVDRYDLSKYIGESRGPYSVDQVALRCLAEVFSRFTPPPGFVDDVAQETETTTPAVETDGVVERSVAPTFVEMDGNLLCDLNITLDDTLKRNEEAEAPQENLIEDKISSYERRLAMGIEPAPKVCKPNIGRSYKRVMSIYRKTLAPKKLKWDSVNRDKLTWSAVYQKWERWSKKHPELARSAQSPTKRQVVSDGSKTRIRKHQLQVHQKRIKIREGPPKIKQKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D488</accession>
    <name>A0A061D488_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA recognition motif domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767574.1">
        <property type="nucleotide sequence ID" value="XM_012912120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D488"/>
    <dbReference type="STRING" id="5866.A0A061D488"/>
    <dbReference type="GeneID" id="24563929"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205460"/>
    <dbReference type="OMA" id="YAHVEYR"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="272" mass="31200" checksum="5C47F162E1E79290" modified="2014-09-03" version="1">MTDRSKNIKLFGPLNMYTIKFTSVGNLPYEVTESELRNVLQGCGNIRFLIIRKDKQTNKSKGYAHVEYRHEWEAVEAFKRLLGKELRGRILKVDFCEDVIRSRHPDLVAAAASVFQNGVAIAVSQSPSVFPDFVFETSTHVNQTPFLYPATQHIPFNNSSVEIAIHQDEFEQKRGRCDEEMLIDEKGRICNRELLRLVKEMNMFDIAKYVEEIDHMISKSPMNTRYVLQGNPKMQSALIHAKVLLGSTSLDLTRATKSVQEFDVALDYFNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4B8</accession>
    <name>A0A061D4B8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767609.1">
        <property type="nucleotide sequence ID" value="XM_012912155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4B8"/>
    <dbReference type="GeneID" id="24563964"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205810"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7675" checksum="9AFF6943A6428EA3" modified="2014-09-03" version="1">MVYNVLTEAPHNLKEGIDWLVALKGTYGENNLKTIVGAIQKFLSYHRLHKPQEAKKHLSYENINLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4U3</accession>
    <name>A0A061D4U3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0102960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766160.1">
        <property type="nucleotide sequence ID" value="XM_012910706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4U3"/>
    <dbReference type="STRING" id="5866.A0A061D4U3"/>
    <dbReference type="GeneID" id="24562515"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102960"/>
    <dbReference type="OMA" id="EFAVMLC"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="358"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR93974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="946" mass="106408" checksum="B374FED0D6D254BB" modified="2014-09-03" version="1">MAPKKKVVVEEDDDELALLDEFNTARGAVIETKTEDVSKSKKKKAGGKKTKVDDDEDIDELLKDLNELNAKGKQDAEQAATVAPPAPEPDAAGEDEKDDAAEGGQPSAKSLKNKLKKEKKKQAKLAKQEGEGEQEKAAETAKKPISLAARLAAERQRQLQELEEKARQEEEQRRLLEEEERRKAEEEEKQRLAMLEKKRQQRKEKRERQKQQGKPMTLKEKMAAEMKKKFLEQLAKEGALDNKQDDEAKRQQPSQTYRKKKTVKAEEVEQVESEKQEEQVEQEPSPSSSESEDTPSSSDSEDVVDNWEEMDIENEEKQEKRVKETVKEVAKPISAPTPKAVRTKVAKPVESEDDESEYRSPICCVLGHVDTGKTKLLDKIRHSNVQNAEAGGITQQIGATFFPKEMLNKHCDMVNPEFKVKSPGLLIIDTPGHESFNNLRARGSSLCDIAVLVVDIMHGLEPQTIESIGLLRARKCYFVIALNKIDRLYKWEPTPWATFHKTFDKQLDHTKAEFFERAKKIMLELSEQGLNSEFYWENDDVRRNISICPTSAITGEGISDLICLMLQLTQKIMVKNITHKEEFHCSVLEVKVIEGLGTTVDVILLGGTIREGDKVVLCGLSGPIVTTIRTLLTPQPLAELRVKGEYQKHTSIKAAMGVKIVAQGLEETVAGTEMLLVENEDDIDKLCEDVMQDISSIFDNVDRTGVGVYVMASTLGSLEALLQFLTDKKIPVFAVNIGTVQKKDVKKASIMREKGHSEYSVILAFDVKCAAEAEKEAQTLGVKIMSADIIYHLLDSFVKYLEETQEQKKQARISEVVFPCELTILPHCVFNKKDPFVFGVHVDNGILKANTPLVTIAKGSLLTLGRVASMEHNKKPVDKAVKGQEICIKVVGEPNIAYGRHFDCNDRVYSRITRDSIDVLKEYFRDEMTNDAWKCVIHLKKVFNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D561</accession>
    <name>A0A061D561_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0209540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767987.1">
        <property type="nucleotide sequence ID" value="XM_012912533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D561"/>
    <dbReference type="STRING" id="5866.A0A061D561"/>
    <dbReference type="GeneID" id="24564342"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209540"/>
    <dbReference type="OrthoDB" id="365111at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595985" description="Prokaryotic-type class I peptide chain release factors domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="7">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="239" mass="27660" checksum="AE5B8715B725ECCE" modified="2014-09-03" version="1">MRTPLLLLLVYILPVNLAASLFLRRFSRDSTPWGFLCPVQGAYQLPSCHSSHYKPQYRELSGPVAVREKYRGVFRQHFCVAAHEEEGTAEPIQHSPPGKSAEDDTLAQLRRELRERHGSEHPLREHYIKGTGPGGQKVNKSANCVQLIQFSAALGTNVVVKCHMHRSLLDNRIEATRILLRRLDEAEEQQSRALRRLAEKEKRRILKLTPAEKARKKFEKQLRAEKKATRRRWKVDEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D578</accession>
    <name>A0A061D578_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0209790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768012.1">
        <property type="nucleotide sequence ID" value="XM_012912558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D578"/>
    <dbReference type="STRING" id="5866.A0A061D578"/>
    <dbReference type="GeneID" id="24564367"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209790"/>
    <dbReference type="OMA" id="THEKHCF"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="97" mass="11343" checksum="34067EF7A897043A" modified="2014-09-03" version="1">MVDNEIAAGIRPETVVKHVDMDEPTRRFAIDLATEAIEKYKIEKDIAAYIKKEFDKRFEPTWHCVVGRNFGSFVTHEKHCFIYFYVGNMAILLFRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5D5</accession>
    <name>A0A061D5D5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0204050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767433.1">
        <property type="nucleotide sequence ID" value="XM_012911979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5D5"/>
    <dbReference type="STRING" id="5866.A0A061D5D5"/>
    <dbReference type="GeneID" id="24563788"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204050"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="381" mass="41790" checksum="2174A319B29639C9" modified="2014-09-03" version="1">MIPVFSVAGQRTGIVTRARFSPAPADHRAISIETEGSITLIDLPSLKYATSNWYSVKFGPFAQAAYTPLDFAFSSDGRVAFVADSGGNVSLDAVNDIGNHLSKVHKHLISIEHAHDGGVFAIVPSPAYEFLLYTGGGDGMVRIWDLRYMGNGNPMLQIPQGGPIPQEVHPASQKPVHEMWAHKNAVSAICFPEKSLMLTAGIDENIRLWDNTQKTVIATIRSYGTALGIWDIAYNRPLDRAVVVGQSTDVWAFYTKDFWGTSEPDQHDMVKIDFEDDDISTVGAFDRWRRPCTHGTNVIIPTLNNRNGAKILFVDAKTGKESRRITTDLVDRVHTVDMHPNVYSGLMLTGAAKKGCAVTTVWMEGEPECAKKTETSLTAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5J7</accession>
    <name>A0A061D5J7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rsm22,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0209610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767994.1">
        <property type="nucleotide sequence ID" value="XM_012912540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5J7"/>
    <dbReference type="STRING" id="5866.A0A061D5J7"/>
    <dbReference type="GeneID" id="24564349"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209610"/>
    <dbReference type="OMA" id="GFRMIHS"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="565" mass="64789" checksum="B8628668CD66550E" modified="2014-09-03" version="1">MACKYRVQTIICRDGSIYGGYTPHIQHIGKFVICGAVQTRCIHHGFQFDRISPYKPNNTIPSNELDDVSRISIKTLPFPPLIKDKLFQLIKAAGKKKDIDASGSYIAKRLAARRCVEVPRVLPSILLDSDSANTEYFEGMKQLSDEPEFFHLKTLFQQNKLGVNEQAQIELAEAEDARHKNSTIHFSPNIAVAHTAHTFFGHYAVCLRIFNEVVTISPIINTRVQMKLRARQFKPTRIMFYNAGAGASVAAAHTIWDLNTFEDILVVEPSRNLAKICEYLIPGFKNMRFQSDVYESTDFFDCVVIPYSLTDIRGFEARTLLVKNLWNRIKVGGYMVMVEAGTPTGFRILHSIREVFISQLEKGRFHFLAPVSQQMHFACFKVIQCPHEGFCPLALTGKDWCHFSQRIYRIPHYLYQKGSIARSIDNEKYSYLVVGKSAGPRHLPAFEMGCRQKLSNEADAKNAQEKSFFWPRIVMPPLKLGRRVIMDLCSAPNNFKRIRIQVNIMSPCIMRFRCARDAMWGDLWRFPHRDQRPIARAYMPDTVRQRLIGKPKTGYKNDRAHKGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5M5</accession>
    <name>A0A061D5M5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0210010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768034.1">
        <property type="nucleotide sequence ID" value="XM_012912580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5M5"/>
    <dbReference type="STRING" id="5866.A0A061D5M5"/>
    <dbReference type="GeneID" id="24564389"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210010"/>
    <dbReference type="OMA" id="RCHDYRR"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="557" mass="64478" checksum="89F20DDEF1E1B777" modified="2014-09-03" version="1">MRHGIGGAVAYPHRRKTHVKRSTSIIFGRTGGTVSDAELGAMHDEFDPYASSGTPDEDVAEEYVRVARPLRSANGEGSARRRANSAPNRNFGYWYLNGHSSYDDRSHHSGRPLHETLHTEFRPSLLSGHMQHLDLQGFMNLAFVILVVINFRAVIGNFRKYGLLLDIPTLYNFKLNDWPLTRCCIKVHITIVFAWAIERFIAPLSRKPLTVPVVFLQMVNLGIVFYYPYLTVVVLKTQPAWSALMLATSVVWGLKIYSFHHVCFDYRRAVCNGEKISDICKTRMEAKAAANYPGCIKLTELYRFLLMPTVCFQFYYPLIRKIRWTRALKHFVQFLFLLAVARIIGDQYIVVTVTNTFTMQEFKSANFSTVAYHILDRMLLLSIPVLYCWLTMFVVIFHHWCNFLAEITRFGDRRFYDDWWNAACFGEYWRKWNLPIHQFIVRHISKPLFKMGVPWEMSSVIVFTISAALHEYLISVPLGLGWTGYVFCAMMGQIPLLMITRVSVVREMAVEESSITQFRKNRTLGNVLFWFLFCFTGQPLGVLLYWYLWGVKQGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Z5</accession>
    <name>A0A061D5Z5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL/TRIO domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768169.1">
        <property type="nucleotide sequence ID" value="XM_012912715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Z5"/>
    <dbReference type="STRING" id="5866.A0A061D5Z5"/>
    <dbReference type="GeneID" id="24564524"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211300"/>
    <dbReference type="OMA" id="WAFSTVW"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="102"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="313" mass="36326" checksum="92084ED85657CD43" modified="2014-09-03" version="1">MGKHNATDLLRLETNAEQTPEELQGLVSALNDEQRMRLEEIRSLYSMHISGNQQLFDDLFFVRFLRARKFDINKTSAMLNKYFSWRLEVNVDSIIRSDLTYIRDRVREFFPHGYHGVDRLGRPIYIERMGQGSCTKLLQHLTTEQLTRYYVQRYEYLTHVMMPAASLKLGKPVEQLLTIVDLRGFSLSQINTKLRAFLTAMSSVTQNYYPEMLGKLLFINASALFSALWQILSPLLDAKTLSKISVISSKTESRQLVFELVDHDQLPIFLGGTRPDEDWMTANFGPWDDPEILDELRRTRPHVPAELYDLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D617</accession>
    <name>A0A061D617_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766545.1">
        <property type="nucleotide sequence ID" value="XM_012911091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D617"/>
    <dbReference type="STRING" id="5866.A0A061D617"/>
    <dbReference type="GeneID" id="24562900"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106680"/>
    <dbReference type="OMA" id="PYYMVIL"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27061" checksum="1DD35E8BF1718CE0" modified="2014-09-03" version="1">MHSINGIPIDGNTEIDDLALVMHIAQNENERIRELEALGRPVLGAYPAYVVIYERFKNISRPREESSDSDSDDSADDLDLVRRELHVSSAGTNATDNDKEKDYQPAVDPEFPIDNIRIIDTVDLPTKVADQFPIAPIGPCRVLDLGSIVCLNDRRIIGTVSDTFGNTSAPFHMVVCRDPSMVKAGDAIFYDVKHSTLVSDVNVMETASSISSGEESDEDNPSKSHESLRQPVKLKQYYNDLECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D658</accession>
    <name>A0A061D658_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-NAD-dependent kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0211850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768229.1">
        <property type="nucleotide sequence ID" value="XM_012912775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D658"/>
    <dbReference type="STRING" id="5866.A0A061D658"/>
    <dbReference type="GeneID" id="24564584"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211850"/>
    <dbReference type="OMA" id="LNEMCIK"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="385" mass="42603" checksum="F918C069F3F6DDB6" modified="2014-09-03" version="1">MEPSGCVEHPLTLDPADVAKRLSVVGDAWSNSEVHDLVVVYSRVPKKVMICSSKTDESIRKAREELVALIKEKFDCVVMVHDRLLPSVKAGTDQLWGEVHRPHPGPAASKNQDDSTIVEYKELEIDDVELIIAIGGDGTILKVIKMFPHVIPPVIGLSMGSMGYMAKFNMAEVKETLMSICDVGITVSRRSLLHVEVYSDTGELIARRNALNECVIDRGLSPCITTLDVYYQGSYFTTVIGDGLLISTPSGSTAYSMAAGGPIVHPAVPSMLFTVICPHSISYRPVILPREAVLDVIVPPDNRGDVRLCVDGNYHCNLKQGSYVRVTSADQAFPLVLPNNTHTGDEWIRSLREHLHWNFRIRQQHIAPRLQLSQTLVEKRFSTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D672</accession>
    <name>A0A061D672_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766610.1">
        <property type="nucleotide sequence ID" value="XM_012911156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D672"/>
    <dbReference type="GeneID" id="24562965"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107330"/>
    <dbReference type="OMA" id="CHDYEVC"/>
    <dbReference type="OrthoDB" id="360994at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="670" mass="76811" checksum="9D020D93A70173C9" modified="2014-09-03" version="1">MPSEVDSKAATPATKMPGAKEAAAQQDADGGETGYREYAVLDLHLNQFLSFIAEDYSFLPCAIYKPRIDVYLDGKLMYKSRVLAHEDDIFGNVIRLRVYSPNSLLTLKLYECVQLRLTEKSVDELIRPMLRNEPTDEVLISWCNIELSLLVPAQRYDMVCAFRVNPMFVHYNPGGILYYPTVNGKPFIENKRVCCACRVCVFLASNTLTVHEKVLNKYFDFRCDPHEAPLPWPANSKDQGAASMSDSDGGKGGTNYARPVGRKELDPDKKYKNESETVVKMMREKNYTKEKPVYDIHQEDSKLETFEMNVKKIFFTQENCTCCRLVDVPKQLRGINYSPCPCCHDYQVCCEHSLETYYYTSISLKLVSKTPIDFKTELMALMNVPPGRSKDTHERNDSLCSIVTRVFELRAQLTMLNCHLGFSSGREAHQQYFYVFVAIIMLGFILDGKTLTVSCFLLGFITMYLHNTSLKQYQHDFGDVIEASRRLTQSGEGLEKTIREMVEEEEPVSAVEPEDRHQRNMKCVSKHDFIDDVKLFSKLNTSLNRKENISIKTMALLLSSSIPKSLRSTLVTTVEYCESFVWCVNAVLAAIRRFGPHLCCFFCSMGFLSLRYAFWMKCCIKAVLILCCTSALVEEHSVVRRRFSQLRQVAKYLAMRIYRNEWFLNANSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6S8</accession>
    <name>A0A061D6S8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768587.1">
        <property type="nucleotide sequence ID" value="XM_012913133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6S8"/>
    <dbReference type="GeneID" id="24564942"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303050"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="10150" checksum="F40486C38232B845" modified="2014-09-03" version="1">MAVYHTRIAESLYFGVRLPQNKRCLEIEISLKMSDEDDWKAGIGAAVGGIIGFSALLVLVLYIMGKIYNISLGEIFGQIRDGFRDSKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6T8</accession>
    <name>A0A061D6T8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorting and assembly machinery component 50 homolog A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0301570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768439.1">
        <property type="nucleotide sequence ID" value="XM_012912985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6T8"/>
    <dbReference type="STRING" id="5866.A0A061D6T8"/>
    <dbReference type="GeneID" id="24564794"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301570"/>
    <dbReference type="OMA" id="MIGTNVN"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.310">
        <property type="entry name" value="membrane protein fhac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="134"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="469" mass="51675" checksum="505E8DB055536499" modified="2014-09-03" version="1">MAERQPDATAASSEPEGGQEILHLDVSKTVGDIRVVLKGLSRIRISTVQPDLMSIKRANTVEELLSLLDESHGRLNRLGLFKSVVSNVQRGKRPGDVDVVFEFEEKKASYSVGVTTNQKAEGNVVITGEIPGVLGSCNSLSLQLNNTGYGSQKIATSFFMPRNIGLPNFTSLFQIFTSQSNFTNYSSFSTTAKGMSFTLSDISKRHQISWEGSVNDIYPIFNERRRASETVLRHAGRSLKNAVSYQYILDSLKGDGIPNGGHCTQFKMEAGLPGGDRQFLKFDCSMLYATLIRQKYIMHTNVSMGYMRPFGTLLSGSSLLDRFHFTGNGGAGTAFRGFGFRGVGPCDHGSVYNSETKTWQSIPEYTGGDCYGNLQLALHCPLEYKDYRLPLAFCFLNVGALADIEGRQTHESVYGHMLREMRMSVGAGLSISVAPGCWFETFVAQPLMSSPTDTVSRVQMGLRFKHNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6W6</accession>
    <name>A0A061D6W6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767928.1">
        <property type="nucleotide sequence ID" value="XM_012912474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6W6"/>
    <dbReference type="GeneID" id="24564283"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208960"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9562" checksum="0CAF7F86C63B1887" modified="2014-09-03" version="1">MIAKTIKAITHQYIVIRWYLKTIIGQSHNVQGLDPLDFELCLISEEKTFNICIDAPFCNAKDTPSFRIMLVKFQQEFKHCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6X6</accession>
    <name>A0A061D6X6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0303600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768642.1">
        <property type="nucleotide sequence ID" value="XM_012913188.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D6X6"/>
    <dbReference type="GeneID" id="24564997"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303600"/>
    <dbReference type="OMA" id="ILERCCL"/>
    <dbReference type="OrthoDB" id="364317at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="4794"/>
            <end position="4811"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="4579"/>
            <end position="4767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3641"/>
            <end position="3664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3985"/>
            <end position="4041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4057"/>
            <end position="4330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4418"/>
            <end position="4499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3988"/>
            <end position="3998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4027"/>
            <end position="4040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4072"/>
            <end position="4089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4090"/>
            <end position="4104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4162"/>
            <end position="4176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4201"/>
            <end position="4227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4234"/>
            <end position="4249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4268"/>
            <end position="4292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4299"/>
            <end position="4309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4438"/>
            <end position="4460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="4945" mass="552947" checksum="8E91E2A7BC7858A8" modified="2014-09-03" version="1">[encoded data, 4945 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D717</accession>
    <name>A0A061D717_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766905.1">
        <property type="nucleotide sequence ID" value="XM_012911451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D717"/>
    <dbReference type="GeneID" id="24563260"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="20223" checksum="00D83ECC8DC42CFB" modified="2014-09-03" version="1">MGDGEFPWLRLRGLGAAVVEGTGIGSGSVAVGELRGLGGRGEDDEREVYKRRRSMWTALTVATDVRFISKITEQASSAILRDVLKEQSRVQTAVVDVNVVLRNSSHTSLGSDSLPGLAGARTGGLDSHGEDLSTTSTLSPPNPQAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D761</accession>
    <name>A0A061D761_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0304590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768742.1">
        <property type="nucleotide sequence ID" value="XM_012913288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D761"/>
    <dbReference type="STRING" id="5866.A0A061D761"/>
    <dbReference type="GeneID" id="24565097"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304590"/>
    <dbReference type="OMA" id="AFDWSTH"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="171" mass="19478" checksum="7E2E6EFF1B746CF8" modified="2014-09-03" version="1">MSSSALRLYTVFSTAVCAAGIALAFNYLSGLYHRSHAFAHGSVSHVQTFELKTISSQSDRAALELHLDYDLRNVFDWSTNVIFLYVTAEYETARHPRNELIIYDKVIEDPSEAYEPGRNIVSKYYMVDFGRSLRKTRVTLRLFYSFVPIGGLISSHKLGESRFTMPSDYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D762</accession>
    <name>A0A061D762_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766940.1">
        <property type="nucleotide sequence ID" value="XM_012911486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D762"/>
    <dbReference type="GeneID" id="24563295"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110520"/>
    <dbReference type="OrthoDB" id="366608at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28144" checksum="B72715CF5108202E" modified="2014-09-03" version="1">MAYNSLTQVPRNLKEAVDWLMALKGTTPDANLTAMGVALHDFLAEMPVGLKRLQALEKIKSITRKFLRNPELSIQPFVFDLLRRFNGPMNKTYRGLRGNVMIVNDSDYKNFIQTDRLQPHDIANGLGTLVHGCEHMLANITDPEEYKSSYTSEASWAGSCQADPEACAVVFVGIAPMLYAGLRSLRAVGNVATQNASMPDADDRIEDVMEALGYVAPERRGEMTGPEVRKAMRSLPVHTLDLVYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7D7</accession>
    <name>A0A061D7D7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768078.1">
        <property type="nucleotide sequence ID" value="XM_012912624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7D7"/>
    <dbReference type="GeneID" id="24564433"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210450"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28016" checksum="4B4417531712CA2B" modified="2014-09-03" version="1">MVYHSLTEAPHNLKEAVDWLVALKGTDAEKNLRAIGAAVHKFLADKPVGKMDVPAVEEVKLISKKFLEKLEFTVMWPTSVLLEKFKRPMNKNPGFFVKAFGFVDKSDYKNAVEAKGLTAEAIAENLGTVVYGCEKFLGEIKTPATYNSAYSSKATWDASCAKDPEACAVVFVGIAPMLWAGLHSLRQTILDEPHRYMSYGVKSSLSDVLKALGYDDDDCLPGVNRPDVGKALSGLKPRIFEFIYDLCGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7L3</accession>
    <name>A0A061D7L3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767065.1">
        <property type="nucleotide sequence ID" value="XM_012911611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7L3"/>
    <dbReference type="GeneID" id="24563420"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200360"/>
    <dbReference type="OMA" id="VNIGNNW"/>
    <dbReference type="OrthoDB" id="366181at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28704" checksum="86165CC843107851" modified="2014-09-03" version="1">MLLRRLCLCAANRRLAGPVSRWIPALRVIEQTPVCLPSPYALTHRDHFASKAKQQKRAKTKQVARSESDDEDGESDDGDDEEYFDIDEHLDRIKEIEANALSALGDLKPVAVTSDDLEEIQINKDKLADLAQVVFKSPIVANLHVFDVKVKSKIVRELTLLRDDWSVQSDEDDLIVLRMPSPNSPQVQQRIAQQAAAVQERHHQMLQQALSKAAAKIKQVNIGNNWHKKQHDQLNAAAKGVRERIKAAVKQLTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7L6</accession>
    <name>A0A061D7L6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isy1-like splicing family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0211290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768168.1">
        <property type="nucleotide sequence ID" value="XM_012912714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7L6"/>
    <dbReference type="STRING" id="5866.A0A061D7L6"/>
    <dbReference type="GeneID" id="24564523"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211290"/>
    <dbReference type="OMA" id="YHWERRI"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="240" mass="27614" checksum="A0936BF75C2696AA" modified="2014-09-03" version="1">MARNSEKANAMLNRWLRVKSGLSMHDINLMRRPRHTSEVEDVRTAEHWRNLVVKDVMISISRIQNASLGEYAIRDLNDEINRLIGLRKRWDERVIELGGPDQRALSSSIENAHGAELKVGGGGYRYFGAAKNLPGVRELFEKQESDQRMADTYVTRAELYRMINPDYYGFRDDEDGHLSRAEAEMERSLHRAHLAEVGELNLDPADLEHDDLEWDESLREIIAEYLDTKPKRVDPGLDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Q3</accession>
    <name>A0A061D7Q3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768759.1">
        <property type="nucleotide sequence ID" value="XM_012913305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Q3"/>
    <dbReference type="STRING" id="5866.A0A061D7Q3"/>
    <dbReference type="GeneID" id="24565114"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304760"/>
    <dbReference type="OMA" id="GRLYVWQ"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="26946" checksum="25091CCA5DDA205B" modified="2014-09-03" version="1">MWRNEPVVAVGDNAVLLLDSKGRVERELSKEGLRCTTNAVAAAANLVCVATSDKAKITFISESQSYKVSVPELITAVAFSRCGEVLYAGSNTGRLYVWQIRTGTLVKNKQVFFNAVTDAKVDFANTTILLAAQNGDLALIRLVELFLKDANGTLYLGHSTAVTGIANLMQGPYKNTVSFVSVSRDKNIRFWHHSKRTSTQSHFLEHTPLAVVPSRTGTRVFVPCEMGHVVVVSIANFDDTFVLSGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U3</accession>
    <name>A0A061D7U3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768799.1">
        <property type="nucleotide sequence ID" value="XM_012913345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7U3"/>
    <dbReference type="GeneID" id="24565154"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305160"/>
    <dbReference type="OMA" id="NYSVINI"/>
    <dbReference type="OrthoDB" id="363455at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="71"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="347" mass="40545" checksum="B4BD24607790E425" modified="2014-09-03" version="1">MIRTFTQRRCAAYAYPGASKMRWFFVKPYVRWEPDKLLHYPEVSHVDSKRIDWLYTEPKSRYDAVDIYGPNTIELSNLPMGRTPEYLQERLRRFFSKFGTITFCRCMPHDLDPYQCNGTGYVTFRSKEASVAAASANLVFPYALHSKIIAIRHLDTDKTNDPDYVHKQRHYIKQTVDIARQLYNKLTRQGPCALRDVSTGIYERNFYSGKWHKAGLSVLMRFGAWSDFLTSNGLNGMFDVSGGRVTLGLQCDDTAEKTLQTLFIQQSRALEDELTVHWREGRMPLPPEVQEEVDELYHLKPLPVHLQLLSRSQTVYRIHDERHMFKIQLKQKRNEARRLARAAKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D882</accession>
    <name>A0A061D882_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768924.1">
        <property type="nucleotide sequence ID" value="XM_012913470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D882"/>
    <dbReference type="GeneID" id="24565279"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306420"/>
    <dbReference type="OMA" id="IDFTELM"/>
    <dbReference type="OrthoDB" id="366006at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596078" evidence="1">
        <location>
            <begin position="21"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="573" mass="64578" checksum="74BBD6BC7F1DBA85" modified="2014-09-03" version="1">MLWIKRAIVALASLSVACNGMRIAPRLGTVGMPLCTVASKPQPNQPEPKSLNTVFLVLPEKPDLTDNAALTKVDIGDHQCAVIKVDHNVGAGASDNKEANVIQLLSNAYKIGLNELANETVYEKRKNHTNIVELAITTLRADGVLIPVEYHSLISMGRAVYQLQLLDLVLLLLRQIDDVKLNLHFVVYNYDERRGDDAARNDFNERREKEIQAALAQMFQSANDLVDISVTFTPHTKVGQYLEATSGWIGNRISLKQACPIEFESESNKKEESVTKLRKIQGHMDSSVNDVAGKLKEVDLSKDTRPLRQLLEIANEVELSVNKWLGESAVSLAEMPDKLKVQADTLVKALVAEFDSRARQVAGRTEALYKLVRRNMVESLQNKLMVMMDGMALKIQDTVLQEFQEELQSISVDENLDLSLQEAIGKYDRRYCALVEQRRFDILRGNKLYDLKAQAQRRDVIESMKDVANHVLEFAIAKGLFYAKFSILDGISYIPSNPVTRFIAKWIKLLKIPLRISLHYLSPTAFGFSNLFRDRIPLKPGMLRYFTDGRERSTFSKDPSTRALANSLVYSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D895</accession>
    <name>A0A061D895_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767325.1">
        <property type="nucleotide sequence ID" value="XM_012911871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D895"/>
    <dbReference type="GeneID" id="24563680"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202960"/>
    <dbReference type="OrthoDB" id="366500at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="27233" checksum="7AD34BA07665BA77" modified="2014-09-03" version="1">MVYTSLTDIPRNLKEAIDWLVAVKGTDAEKNVKAMGAAVYELLADKPVGFTDVTALWNVKFATKKFLQQDEIKDMWPVKELSKRYYEFMDKSPEAIAKAPAMVPKSDYENVIKTRGLTAEVIGQNLGEVVEGCEKLLQGIKVPEQYESAYGSEATWDASCAAKPEACAVVFVGIAPMLYTGLGAMWDASHLEMSKKSAGAAKVLQALGFVEPQCRAGMTVSNALRGLRGIDLHILDTLYDLSGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8N0</accession>
    <name>A0A061D8N0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769257.1">
        <property type="nucleotide sequence ID" value="XM_012913803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8N0"/>
    <dbReference type="STRING" id="5866.A0A061D8N0"/>
    <dbReference type="GeneID" id="24565612"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309740"/>
    <dbReference type="OMA" id="YYIERIE"/>
    <dbReference type="OrthoDB" id="364025at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="797" mass="90186" checksum="234002B8412C614E" modified="2014-09-03" version="1">MMSQVPSCCRSCKRSDSPKDETEKEDPNHVETLRFKILSAEGKDTDAPCGRSFGPISLLEFFGDMPQIIKDPIKEAIASQVAGYKTEPRDRSRHPKRHQPTAINTLNITRSFDVNGKFAMSRSITIESTTNASLAWGKLTTSLPLFESEGEPTTARRDGQITLTVGAHIINGKYVDLESGDHFLVLRKVEDHCSCICTNGTSDGECTETHEAYFEISGVTRAKVVFSERPSIIQHSADMGDGSPWFICPSEDLELTDPQWLLIRVAHAMVDMFTAEQGYFKLLKNYSGSKQSRLVLSLRGETYLLERVELGGKILLVNPMRVNADQDKSCNILSVVGRCTYVHNLIKTAPNLSSTRKEEKVSLQTILDSLPASDAQIKRFLMNAVPASPCDYMYTGGVKFAYLDPILSAEFSIALLRTLDIHFAKSEKPKSDALNPSIRDVWTMVMSFQQEFDFLPPHMRTPKSLFQIMRGLCDIREAFTDLEDYLNNMGDEDKLLDTNMQLNLFKIHRKIVRAIIIANEKDKMTYLAVVKKIDSLLFGPSVPSYLFDGMIQYLINGRLESDDDIVDYVTCLKFYYERLSFTDVAEKMSRIFNNKTQTPFDATQFSLSGKKLFAVDTGYDNEVVESKSACLNYGIFKLNTKGLTQLRFKHAMNFLLSLCRSPLSLHLSFVSESLVAKDDGVTCMLQMYRKEDECCLRDVLSSLFTINQRWNLEDMEKKMARFLGSRTALESVTGPPNFHARVWITKQKNTLNYERTDSEEEHRKSFESEYTSALGDGMLQHIEEEAYIIINSNVPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U3</accession>
    <name>A0A061D8U3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0104740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766351.1">
        <property type="nucleotide sequence ID" value="XM_012910897.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8U3"/>
    <dbReference type="GeneID" id="24562706"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104740"/>
    <dbReference type="OMA" id="CKEQVYE"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="747"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="1622"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="1750"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1903" mass="208636" checksum="2A856736D93A4725" modified="2014-09-03" version="1">MSLTGKCACVEKLSQLHATVLSDLHPCKEQVYEARVSQLQSTIDTLQLRNADLCTQLADIRSRIAADPFLSSKFQCVTEKSSEEPSRIYGVNLDPTSSPADVYRQLCVLADRNRDLESRLFTEQAISMSWKHKINSLEQRLKEQLDDLVYITRDVTCMKDVDCAGKRSDRREALTKEALELLKLARLRIDGDRTRMEMYANRIADLERELLEHRLKASDAASQLDHSSAAAAISQRQADITGGRPASTYPLRHAAQPDSCVAFGTSALMRELEMSKGSLRHGVWNNVDGGCNVELSQSELLSHSASASQEDDRRKLIRLYSDILTLIRKNNVQAIPPVTQMRSMLRTGSQVDRNSESGTGETPINNFPIPPHKVDEDRIDKAVAKNHDYHITPGDLACMPSVSVVKREDDASRTVRAQPSAASNTDESAFSLEERLISTSKTLPRNESENSDPADDSRQGDTLLLSSESATETQSARFTDVNTQMDDSPSSDDTVMLSSSSMDNGSPVSSDTCDGSHHDGSAPDDVSMAIGVTNCESNQSVKIPDDISEDLASSSARLGSSDTSISNPRADGEVKSSHLGSRLSSVEHVADKFDHPSPAVEVTSKICTMTPEPVNGTASVSGTPRSSSASSLHDNTKPAESGVLAGSDSPLESRFSDSPSSLGKGSPDVSSQILRGHESKSVEFNGIDIPLSELPSYEFGTACENSMEDQTMRRGDTLSVNGLKSFVSAQKREMLDALLLLLQGVPVLNELSEERLRGLLPYFKLQSYSPRAAIILAGEQPRCFYILASGMVSAYSYESFDKPNRLLRRYLNADYFGELSLINNRTCTSYIIAEGHVTVHAMEGQDFVEQLSDLFPKFMERAMAEYDKSNWRSTVSPSPRVNRKAVEDLPDITTFISNVPIISTASHMDSFISSFAYRKFGAKEVIATSLTSLPYLYVVYRGSVAVQLRESESAEVSEFAVLDPMSFIGGVCFVDPHVQWLSSASLVATSETILLFVEADTLEMQPENWKTHVRTYQEQFFVDKMVERKLLQGVEKLSAPPKEITHSGSLSDALISSDSGGFSDGLNENSSITSDRSPQSLHAMGDMSPGQASSSAVSTVKEEDECSDLMDSVLPSPKSSVTSDDLSSVSSQMLEDTSAVVRTGSYKLLNIQRSPVNDVKSGVTPGTTTALIKGVEKKASNFTAYTPPTGHETSISSPVKDISRDIDKNPIAEDDCRSLISESDQFRESDRSESLASDCMVSDRNVDNKLNTEDNTDERDVDANATPRSFARKMKRAPTGIFKNDRKTAQQTLNKAPRGTVGSTTELPATYRSSVGDTELRDSSIDSMIDETDGLSDDTSFDSDLSDLPSSSFSDCSSVTPKNYDENTVNASKDLLIATLKCKCTSLGAAFTFMDANNCGVVFRQRFYDAIEELGIASIESSELPYLFDLLRENDREVMTVASLYRNSGERVSTAQEFCTRLKHVHGSSRVAFEKHFGPLKMSSTCAEADFLILAMNVGVEEDDARKIFKTLDICGNSYVTILTMLKLMRGDWTLDVALEKEQAAVSSYNQIVGYWQNDDYESFRKEFSNPYICVFDILEYGVDVSQVDCGWEEVTSLAIDSSTKSHYVDTLIIPTLETHSYFRQLSPIQIRFVASLFVESRSKTGTVIFSQGDDDFPLYIVLSGQVHSTYITYLYTESTSTDVIVGSLLEFDCFISGQQSPCTYKVGSIGPAVLASIAKAMFREAVQPIIDVRSKRVPVISTFLSKVPCLEGLDPEVIDRIACASVVRKRKNHETIIREGDSTEWMYIIFDGSVDIKVSSAANQIADSVTSTGLLGAEEVAFSLPSYVSTAIANSSTVLLIGWLASSFATAFGDAAERIREASREASLVRSNSLKTPDQQSQRLLSKSTKTVSFSINRTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U9</accession>
    <name>A0A061D8U9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0104790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766356.1">
        <property type="nucleotide sequence ID" value="XM_012910902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8U9"/>
    <dbReference type="STRING" id="5866.A0A061D8U9"/>
    <dbReference type="GeneID" id="24562711"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104790"/>
    <dbReference type="OMA" id="STCILMY"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="193"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="398"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="706"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="739"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="818" mass="91809" checksum="A6BA396CC94B7D0B" modified="2014-09-03" version="1">MAAELQNRFACAQVENNYSEFFGTLSSALLPLSVSDDVKEHGGVCDSSSRAAYCITLDELAAFDPATYVDDQLPTIPFRHRQSVHRYRIGNVSAITSDAPGNGRGVGHSDAAAAREEDQDENYFGYAADDNVVKERYKYILPRNEESPPVPEPVSGDQCGAWSGRFEWTDIVHRINKEVFGNASFRPKQLEVINCILSGRDTFVVIPTGGGKSLCFQLPVVYDGTVGRNGVTVVVMPLVSLVHDQMKRLHALGIPCHALVGEMSRLDRENVLGDMRSDIDTSYMLFVTPERITSSKVLLNAFRDLEQRGRLSRFVLDEAHCVSEWGNDFRPDYKEMGLLKHEFPHVPVCAFTATATPQVINDVCAELRLRSPTIFKSSFNRPNLRYEVMPKDRNTNKAIEKLVEVIKERFAGSCGIIYCLSCNEVERVTQAVSKHVRAAPYHAQMQMHMRTGYYREWISGSVDVMVATLAFGMGIDKADVRFVIHFSMPKSIENYFQESGRAGRDGQVACCLIFYQFHDAQRLLTLGLGSDANSKSDKEQVNRKNILSVLAYCESGFLCRRKVLLEYLGETLRDACDVPCDTCSSNQEVKFVARNCQKEVIFICNGLITQGKQYERSNDAYTLVSLHKLLTQRNAGDHPLSGYLRRMGFTNDAAMTLLKRMIIHQILIERVARIAQQSYTSFYLRVNPQYRTYLHHMGALRFPIETNSNKRAPKQAAASSNKLPTNLKKAAASPKAPRTQKEKAERKPREPKKKETAEKKPREPKKAGAAVRKPREPKMKDAAEKKTRVRKTAAEGKLTDKTPSARAKAATEPEADIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D912</accession>
    <name>A0A061D912_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766406.1">
        <property type="nucleotide sequence ID" value="XM_012910952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D912"/>
    <dbReference type="GeneID" id="24562761"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105290"/>
    <dbReference type="OMA" id="FHRNECE"/>
    <dbReference type="OrthoDB" id="394396at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595584" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="183" mass="20967" checksum="0CD912476E449B2C" modified="2014-09-03" version="1">MNIELSVLVCVVNCLAIASCHSYGKGSHELATPPKLRIPEGRRQIALVATRKGHKYPYLLAFHRNECEFCQDMEALINRANVEHNLHIKRLDVASDNNYELMVKLDRKSKCGGLPFFYNLLTHQHICGATNYRNLIAWANGKYLSNANPYPLKEEEIKASYRRSGLYARIMVKLRNVSLYTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D984</accession>
    <name>A0A061D984_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0311540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769437.1">
        <property type="nucleotide sequence ID" value="XM_012913983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D984"/>
    <dbReference type="STRING" id="5866.A0A061D984"/>
    <dbReference type="GeneID" id="24565792"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311540"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="2">
        <location>
            <begin position="106"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="273" mass="30680" checksum="9DEC097DC16F3172" modified="2014-09-03" version="1">MSTDDIEKLVADLQGAFSEASSDPRAVAPCAGILNKIKERLTQCHLKGFSGDARFLSLAREAYEIGALLSLQLGDVGSFDCYYSYLHPFYFDYTGVVQRSERTDVVLGLRMLHLLTENRIGDFYMLLELLPADIRASRNIQYVVELERSMMEGKLTRLIDVRQTAPSAYYWSLADKLADTARNKIAAAMEIAYPSLGMADAAAMLKLRDVNELASFMNHYNKSRKTDDSRAVQWRIEGDRVCFVSEAPVRGSVPSKEMLAYSLGYIEELEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D990</accession>
    <name>A0A061D990_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769442.1">
        <property type="nucleotide sequence ID" value="XM_012913988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D990"/>
    <dbReference type="GeneID" id="24565797"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311590"/>
    <dbReference type="OrthoDB" id="364904at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="205" mass="22913" checksum="8B2FCA1BF35CFDFB" modified="2014-09-03" version="1">MSVESEREALIRQHNKLKAEVESINNEIKKLERANEYLRQQNANMRRMVEQSQAMAAAMAPESSVHTSSGRYDDGDLVKTPEARGGHFYQVVSDLTGNRDSVLGSYLKHVAGVADDFASKLHVTEGDYEHPPARESVLQHIYRRTDPAYMMVPSLSSRESGIDTSSEMGSPQVEPQYVERTGYFQEVTAAYGSDKRGDFPPSLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9B8</accession>
    <name>A0A061D9B8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769467.1">
        <property type="nucleotide sequence ID" value="XM_012914013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9B8"/>
    <dbReference type="STRING" id="5866.A0A061D9B8"/>
    <dbReference type="GeneID" id="24565822"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311840"/>
    <dbReference type="OMA" id="CYFIADR"/>
    <dbReference type="OrthoDB" id="360617at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="623" mass="70643" checksum="731A3E7758DBA01A" modified="2014-09-03" version="1">MRFKQQTRGQHASRVAEDVPREPRMLTRNPTVEHAGVVRNIGDCPLTLRRSISAWSSAEFQRSTYCQNHPHAFQEYADKGANTPRYQLLSTQSNNENNIALETAHNRRELYGGLSVDEASELRNRPTISLADLNEGVDFEALLYGPLHDDKLKAAHQHSISTADHCRFEQPRPVWHLVNAIASDEVYRNAEDWGIDRSIYTRYARSGFFADCHVADSMHHGEYLSGPDCEEFADCRIPLIVCIISTSREARHNEVQRGIVPLAVHILDRYIEKHKHSMSRLLSIACAHLDLASSENGSKQPSLASSMNASDAAALDAAAVAKHLKSKYKHDNLIKLCFNFSPERRRGDGAPPDGHTNTFHDFSCRNFDTDSCYEEGSEFDETTQKYSSASVMKADVVYNFVAAACFFIADRYNGLSNTSVKALLVKWESICHVFTKTRHAGRYIRENRATALSIIMSFMFDIYFVLEYKLTTPFPCHMVQDLILSTTDFHCSPNPGEYSVYQKIAAIMARIAYVDDTFHKFQPSIITLAIYGVVRRLAVHNEVVEDENAWLLVDETDSEIRRCSSLLINTLIQYVNTDILDVLTQPVYMKHHTDELFSHLFEDLCDLDAGHLRKFANTLMSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9H4</accession>
    <name>A0A061D9H4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">16S rRNA processing protein RimM domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0305450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768828.1">
        <property type="nucleotide sequence ID" value="XM_012913374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9H4"/>
    <dbReference type="STRING" id="5866.A0A061D9H4"/>
    <dbReference type="GeneID" id="24565183"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305450"/>
    <dbReference type="OMA" id="RTFNIFA"/>
    <dbReference type="OrthoDB" id="364619at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33692">
        <property type="entry name" value="RIBOSOME MATURATION FACTOR RIMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33692:SF1">
        <property type="entry name" value="RIBOSOME MATURATION FACTOR RIMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600716" evidence="7">
        <location>
            <begin position="22"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="533" mass="59628" checksum="90C8ACE0B2804EFC" modified="2014-09-03" version="1">MSGMGFCYVVICASALVCNLATTFGIKRASIASHAGFISCGHNVSAYRPSRIADSNAANDFPADVGWDTDDLVLPNKYYKRSKHSKVGFKGGLRKEVETQEERLARTFNIFAPMPKEELMSTSSRPNAPDPDLVADINKYIKHHIEKEKQESAKLAGSGSSPPRKSEKPPKPLAKPVAAPDPQPQVKCPNAILLDKSILFSTPLDEYIVIGKILSPHGLRGHVKVRSLCSNPEIKLCEPGYRFLKFPNRDETVMPIKIDSGKLLDGEKTYRLKLEGVDTKDQALRLNGAFLSVSIRDVPPLEEDCYYSRDILNLNVYLFNDKTKTCLGKVVGFWHREDLVHHPKLANLTEDLIEVEMDIRLSLQTLLALTKRSAELDGETPAASEVVKSKKVTVVTDRDLDMADDVIDAEEVLANSNMMGVHYVKYYTCSICNREFTNYSIALEHDRAHDAGVVTESPDHEHVSNGQEAQSTKGEQIYTLDEYYEKEIKKPVRRFYIPLIKEETIKFVDVPNNSLYVDTFTVFIGEDGNKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9N4</accession>
    <name>A0A061D9N4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0107380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766626.1">
        <property type="nucleotide sequence ID" value="XM_012911172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9N4"/>
    <dbReference type="STRING" id="5866.A0A061D9N4"/>
    <dbReference type="GeneID" id="24562981"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107380"/>
    <dbReference type="OMA" id="IVFHIVE"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="417" mass="46323" checksum="451F88C9652D0ECC" modified="2014-09-03" version="1">MFFGDFGMGGMPGGIPHPRSREPVDNEKLYKTLGLSRDCSEGEIKKAYYKLAIKHHPDKGGDPEVFKELSRAYEILSDPEKRRIYDEHGEEGLDGNFSAGDATDIFDLFFGGGRKQKGKKRGEDVVTQLKVTLEQIYNGAMRKLAINKEIVCDSCDGLGGPREALMSCGHCGGRGVRVQIRQMGAMIQQSQCVCSACGGQGKSIDDSRRCKTCSGKGVVPTKKILEVLIERGVPDQHKVTFHGEADERPNEIPGNVVFIICQAPHDDFKRSGSDLIMVKPIKLYEALTGCSFNIKHLDGRMVRVQTPQNEVIRPGSMFVVENEGMPVYKSAFSKGNLYITFEVEFPVGRVFSSSEKDKLLQLFPCDTQTADAGANVENAKAHEVDPEELQDRIRAQMQAEQEREEEHDNGRVQCKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9N7</accession>
    <name>A0A061D9N7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769582.1">
        <property type="nucleotide sequence ID" value="XM_012914128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9N7"/>
    <dbReference type="GeneID" id="24565937"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312990"/>
    <dbReference type="OMA" id="NCESSEH"/>
    <dbReference type="OrthoDB" id="366364at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="394" mass="44343" checksum="51D3A8788CE20B9D" modified="2014-09-03" version="1">MEHESEVVQPSSLFGVLETCLSKCRHALQDEELVEHYKNLYQSNLFQYNKILLTLQRSVEETQSNAERINAAIVNDEGIKNGIHVELNTLLSNCESSEHRVVELEEERTRAQDLGNQLSAQDEKLARSLEQAAGDLKSTELQTALAYYALLKVKEASHTVDGRITAVERNTNRTKATLCSRQNTHRMMLADLEDHMYFHKLELQRIACIHGELDGQRTAAEAEHKSLLVKTGETKSVIADLIDAKCKDEAELASLDGEIKDLATNIAALRNDVEHLENEVAEKTAHLVDATASNERMNAAKVELSGRHCFARCPRLRLMCKLFRGKLRTLFCSTSASNNEELQSAIAEHRPRIQELEHLLQAKMEELQLRKRELADHSSACNILRMQAADTVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9P3</accession>
    <name>A0A061D9P3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein transport protein SEC13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0311440</name>
        <name evidence="7" type="ORF">BBBOND_0311510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769427.1">
        <property type="nucleotide sequence ID" value="XM_012913973.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769434.1">
        <property type="nucleotide sequence ID" value="XM_012913980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9P3"/>
    <dbReference type="STRING" id="5866.A0A061D9P3"/>
    <dbReference type="GeneID" id="24565782"/>
    <dbReference type="GeneID" id="24565789"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311440"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311510"/>
    <dbReference type="OMA" id="FNNDRIV"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="311" mass="33072" checksum="FD665016FEDCD813" modified="2014-09-03" version="1">MSALASSLSVNLSQVLQKNVHLLDLQYDHYCKYVAAGCRSQNGSEVVILEKDVSADDSGSFRVVSSVSTRCDPVLLCWAPPQFGRVLLVALSDNSISFYQHAPSAGVWQLSLYQEKRDVQKSISCMSVGVSPKGELLCAVGSPGGSIGVIFCEGSFECVEFQAHCGGVSSVCFAGNDSVLSGGSAGRSCQLASGGSDGCVKVWQLVDRKFQLLKTLPLECESKSLTQVKCLCWNKSGDRLAVGTGGNLLLFGGGPEWSECQRVGLPRASANVSASFSNERLVVSCDNECFVYRADDRGAYELSTALQASTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9R7</accession>
    <name>A0A061D9R7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768903.1">
        <property type="nucleotide sequence ID" value="XM_012913449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9R7"/>
    <dbReference type="GeneID" id="24565258"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306210"/>
    <dbReference type="OMA" id="IIGDYSM"/>
    <dbReference type="OrthoDB" id="366139at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="277" mass="30867" checksum="0ECEAE8ACBEE8401" modified="2014-09-03" version="1">MHRIRALFRRAFTPTNGSINVTLSGNDAVCAPQKKLAFRRLVCDRLSLSSYSLLDDDFRRLSRYNCSVLTTNKFVFTGLSAFLVVPGGFALLTTPSEVSYDLTSHQFKLSSATLSWLSATALTFYLTRYHKPQICFSIGVTLVGLLGSWGSLIAELYSEFGCYCGLLTSYMLFGVAVCPYRLRPLRLTGNETLSQFILFTGLRVFNHDPGSALGPGGSRSTPLMPVCVAKPIFWTAGLNTLLLLLTAWRRYYVKEKLATSKPEDIIRRYEATHGRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9S5</accession>
    <name>A0A061D9S5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0311760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769459.1">
        <property type="nucleotide sequence ID" value="XM_012914005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9S5"/>
    <dbReference type="GeneID" id="24565814"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311760"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600724" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="839"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="969" mass="108691" checksum="FC651A3C7A24247E" modified="2014-09-03" version="1">MGISALINAVLAFCAIWLHRGGFIYASEYNFDYQGELLVNNAVVRCRMDIAYPLKETVICPIYVEGTEYVWHPRPNSNEDGDVNSYVSNNGKLRSIPLSNVLLSEAENPLIWLVSNDTSTELRLDFSANELFASTERRLIFICGPKDLVLNAELQRQLHRLDDFDGMQELPWTQETPLTQEIAKIGHGLGVFYLDRGRMDRPLQGCGSRPSPLFDAENEVSIDRKTGAVSCVADPMSESRIGFLCEGWIDPPNCMKYLINNNDEIVTAYPPNAYLNFEESKPWVVARYFINFALPPFHGECRCINPETGAVMAKMKIRRKTEYVCDIASMMLRNRVRPIRGPWCSVVLHPGSTLTIRLPAPVVNSSSIDEQNEGDDDGDIEEDAITVPFSQLPSVYEYETEFLPKDMTTLRQIKSLRDIDHYDEVAYDQALAGDALELDASQISRGEVKLKYRSDKPLALKGGLNSFLYHWKLVSKSENVANETRAVVNVSFALTHHYDIIGSDLGEPSVFDPDRSKDGCSTKPMGNGLGGTYECVNDMSTTDEHFGIHCRPDEELLPGNCASTGYDLYSNSIRPFPRSIRNVTPYPTVGFRVLRMGFINRPLSYACVCVDRSGYETSRLVLASNRKIVNDYVVRRAGESHTPLPYMLLPWSEGVPSSDKIDSPMYLVIYHAPEKTIKMQMGTTLHMTCAFDSELQNDVNTENLETTWLPMPPEEFYYKINEVTDGLELNREKYADSICSTHSALEVVYQTDPKSNEHKQLTIRTSRSAILISKDPISSEHVRMNFVCGKKAEPLDLSSISGDALSADESEPIVSSIIDASEKYTWNVVKVQLETTDPYMQGCGFTYESDELFKPETPEIYDANGQQIGCKIDIQAAGEAAFYCPAPYVLDPPGCFDQVYVDGEEKNVRDISQSLGASRSNHFVTLKFYGKVVGPGETLRKTPPLECRCVTIKGIVLSTIQIENYYAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Y4</accession>
    <name>A0A061D9Y4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0208780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767910.1">
        <property type="nucleotide sequence ID" value="XM_012912456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Y4"/>
    <dbReference type="GeneID" id="24564265"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208780"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="63876" checksum="485EB9F9D9DC49F0" modified="2014-09-03" version="1">MDGVRTDGGGAGGVAGDAGQEPAEGAGSTKANRIKADYGTFGQVLYHVVSFTEGYEQQVLYLCMRIFESTMSFTKSQRTMLMAVSIMSRLCFSLVWGLLADAFETNLVMAAGLLFMGIASILLSSTSRFSSQKIISDEDDEQSGNSSTFTRIHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYLWISVGIAIVFAMHTEKVLTTPYGSMDKFINQISGSFKAVFTNWSAFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDLKVGIAILVTTIGGAAGTAAGGIVIERITSMHKDYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIPDKYQASASAIIQCISGISVSVSFVEIFAYVSEKLHGYAPSTQAIDDMEKGLKDNNTEALRKSTMYMIVVGSLLNIACYGALFATYEEDKKAVEEQNVKVWEERKEIQVKREALKRNAEEVEIKTPLPEEPKEVAMRQKDEPVPPPLPPPVPEPQGRVMEVAVQATEEGVVDPYPMAVITSESEANYTRDNNRHMDKPDFDTAEQVHEYLKTATQSWKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA21</accession>
    <name>A0A061DA21_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768978.1">
        <property type="nucleotide sequence ID" value="XM_012913524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA21"/>
    <dbReference type="STRING" id="5866.A0A061DA21"/>
    <dbReference type="GeneID" id="24565333"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306960"/>
    <dbReference type="OrthoDB" id="365124at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="136" mass="15257" checksum="992EABA16524D0BA" modified="2014-09-03" version="1">MFLTPLLEVLSGTPLIVEGRVRVELLSLTKGELRYECDKRAYASGDFAGLGDVRTAELYALCRKYRMNCSVVDESEWQDGPAAWDVEKVAERIEAFVKERRVAVIFTFDRQGASGHPNHISVHKAATMNPIRSPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA59</accession>
    <name>A0A061DA59_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA 3'-terminal phosphate cyclase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769787.1">
        <property type="nucleotide sequence ID" value="XM_012914333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA59"/>
    <dbReference type="STRING" id="5866.A0A061DA59"/>
    <dbReference type="GeneID" id="24566142"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400930"/>
    <dbReference type="OMA" id="FFMNNLK"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="402" mass="44499" checksum="F58F875F4B2A5F51" modified="2014-09-03" version="1">MGIVRDQTFATKERLLKHLELDSFAYLRMVAVLSIISHTSVTLREDRVLMLHESQMLELLAKVTQGGRIEVEKGKVTIDPGRIVGGTLKFQCSSQVPLSYYLEPLVYLSVFSSEPFRITLTRQGEDVDWEMVNSFSLLESFCSSATVVLRKIGCSSVEFKYKEPYEVVFTNTPLVKIAPVDMSTWSCVKKVRGSVVVRCLQPSLGTNVITGCKRVLNEVCDNVYIDLVTPKGAGNPYVSVALIAEGPSVVYTSDSTVPLKDADTGAKAASISANTSLSKILEIANRKTEASAKPEANTESATSIHERHEAIGEAVARRLLAEISLKGILDTTHQHLPLVFMAMSGDYQVSTFRMGRLNRYSIEFLRKIKQFLGVTFKFVQEEECVLLKCVGNSFQNSGIKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA71</accession>
    <name>A0A061DA71_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin, 10 kDa family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0307560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769038.1">
        <property type="nucleotide sequence ID" value="XM_012913584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA71"/>
    <dbReference type="STRING" id="5866.A0A061DA71"/>
    <dbReference type="GeneID" id="24565393"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307560"/>
    <dbReference type="OMA" id="NIVHSKW"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF63">
        <property type="entry name" value="20 KDA CHAPERONIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600735" evidence="4">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="305" mass="32891" checksum="700B50F2FD11D6D4" modified="2014-09-03" version="1">MSKVIAALLITQVARALCLRVSGGAQQQRAGAFVLPSTAIHAEPAPKRPLRHGAEAVSSSNEPLPPVKAYVPPLAPGDLKYMNQTLHGDFRPANNYVLIVKQEAQEYSAGGVYIGKQPNKEFAGRVLAVGPGRVVPETGAVIPMTVKVGDMVLYDPPTEEPVVSGTSRSRHRPQITYKNQQCVMVTEDQIYARIETDGLSPRPLSSADIRPLSDRLLVRIIDSPKKTQSGLVLARANETDGTIFRATVISAGPGEYTQDGKLLPVTEFKPGDTVLFSDAAADGGAFDLHRTQHAFVRRRAILARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK6</accession>
    <name>A0A061DAK6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative GTP-ase activating protein for Arf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0110480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766936.1">
        <property type="nucleotide sequence ID" value="XM_012911482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAK6"/>
    <dbReference type="STRING" id="5866.A0A061DAK6"/>
    <dbReference type="GeneID" id="24563291"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110480"/>
    <dbReference type="OMA" id="PENTTCF"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="369" mass="40278" checksum="0F2EC3C33E6DF067" modified="2014-09-03" version="1">MDTIAKLQVDARGYVTDEARDKVFRQLLAQTENAVCIDCNARNPTWVSLTYAVHLCLNCSGKHRQFGSHISFVRSADMDKFTREQLIRIAHGGNARAKTYFRQIGLTRQPYDYASPMAQRYPAMLDAELGTVREQAPERSFSQKQPSSDLLDLGNDDAAPKRVEQTGTMSSGLTSNATAAPRASTGIGSMTLGRGSSDATRSWGTRTGSGGHGAGFGGRVDLDFDAFERSIISEAAQKKNLIATRTTEPTPQAREQTPLVTFAPPTSSPQQYAPPPDMSRFAGKTGISSDQVFGRGAYAQHAPMNVTLNPHKTSLSSDEYFGRPPKSRGNSETFEERAVQNIKEGIAIALKEGNRLVGMAKQWFSSHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP6</accession>
    <name>A0A061DAP6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769809.1">
        <property type="nucleotide sequence ID" value="XM_012914355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP6"/>
    <dbReference type="STRING" id="5866.A0A061DAP6"/>
    <dbReference type="GeneID" id="24566164"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401150"/>
    <dbReference type="OMA" id="KKCSTID"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="145"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="497" mass="57599" checksum="660FCB838EAE66D5" modified="2014-09-03" version="1">MQHRTLRCDRHRPFAHVQFKGCYSRRYFSDVANATSEASSNVEQSEMLLETHSAFPSEFSTGERLELLEICHKNKLWRHREIDILMLELWKNIGKLKQSEISLYHKICKEISDNVLLPSPGESERNHFAKYESQFLWDLTVLHNHTLSPTLEQYRKKQDLIKALKKTLEQAANGTLHTFGSCENGLWVRGSDVDMCLEIPNCGHKRQWLSKLNLKNAFHEIYQIRSTLSDTDIISHISIISAKVPIAKLYNRQNHNFCDISINNTVALDNTQFVKAMTRIDFRVVKLARFIKYWATCRCINNRAQGTLSSYTLILQLFFFLQNRSPPILPLYKDIEIVGDDQERNGRFMTNTSDILAKCEYLQQNTESITQLIFDFFKFYSDKRFQGGRVGATVDLYTNEVTENNLGVLVMKCPITGKNVNPFTIRMWQSIYGEFRRVDECIRDQRPIAQICIKSDKPPLETEAETQRIHASMIREIVMALASPRSRAVGALRRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAR1</accession>
    <name>A0A061DAR1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUMO-activating enzyme subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0402590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769957.1">
        <property type="nucleotide sequence ID" value="XM_012914503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAR1"/>
    <dbReference type="STRING" id="5866.A0A061DAR1"/>
    <dbReference type="GeneID" id="24566312"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402590"/>
    <dbReference type="OMA" id="TPSEHIH"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="32"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="11">
        <location>
            <begin position="356"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="627" mass="69194" checksum="DE763FF214376806" modified="2014-09-03" version="1">MSVQAEEIADGRKESVPNHAGLDSLGDPDEYIKVLQDVSVLVVGAGGVGCEVIKNLILCGLRKLVIVDLDTIDISNLNRQFLYKRQHVKRYKAEVACERAREAAPGCDISAMVVDVLTWRPQDVACYDAVLNALDNVRARSHINYCCMHAGVPLIESGSSGFNGQVYPILRGVTPCYDCHAKPRSKSYPVCTIRQIPEKPEHCIAWARQLYELIFGAKDNGNILSDLAIPPMPVGEGVKVEQARSWVRDVFTFLFDTQIAELIDLKDRWTGRQAPQCINYPFTSGDADAAGNSVEEKLPENLEDEDEAADVSKRGRVENSTHSSDDDSPQAKSRKIYAHTVESQSDALSEPISPNVAKQNQQEMKIADKFRTCDTNELAEQFISSVMQLLLDRPDDLGRAVFDKDDPLCIQFVAAAANLRMINFHIPQVSAWDVQSIAGAIIPAIAATNAIVAAAQVMQLVHLLHARRAGGGTISRETLEASRCRFVWVKSCVTGSTPLKKGALCSPDVLDMPNASCTVCQQQLARVELHSLEHWTLAKFASRICNERMGMEAVSIDVDGRNILDPDFMEEDETYAKRIREWTMLQHGLQHQSILTLTSSVSGKQLELQLLVEPSVSSDDFVLSGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAR6</accession>
    <name>A0A061DAR6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0402640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769962.1">
        <property type="nucleotide sequence ID" value="XM_012914508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAR6"/>
    <dbReference type="GeneID" id="24566317"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402640"/>
    <dbReference type="OMA" id="EYIIDGY"/>
    <dbReference type="OrthoDB" id="365958at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600209" evidence="3">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="381" mass="41650" checksum="EF1A2DFE415A969A" modified="2014-09-03" version="1">MLRLERLVVWLLATCLAVSALPKALHSQRPSAASSLQRLGRFLQSKAHSHEPTDGHDGEGDEIAEMRKLGADAAAEGHKQKGEMEVVDSQRKQEIADDMTRQLEKMREGAKRMQEDAKQHAGEVKSAAVDTSVATASIPKDSAGNIIITNQTHDYPRKPQDQADPMKALKTATENLYQRARHKNLPVPEPGELNTPEQIYQALNRLEYIVDGYRHAQLESPNPDLNITDEPEKSQHAEEDELENTEDDAAADESPVDDARFMQTTGKAARAPDDDDGDNGDDDDNDNGDDDDNDNGDDEEGGDDDGEQHGEEWQENEDEEGAGNHKKPADSKDAKMSPQEAMDALGKTIAHLVETLNAVVASHTGVSNVLIQHGPTKPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAS0</accession>
    <name>A0A061DAS0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768200.1">
        <property type="nucleotide sequence ID" value="XM_012912746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAS0"/>
    <dbReference type="GeneID" id="24564555"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211580"/>
    <dbReference type="OMA" id="EWVIRFL"/>
    <dbReference type="OrthoDB" id="359611at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="404" mass="45242" checksum="6C7453A5328C1048" modified="2014-09-03" version="1">MANVNSVSQSKGALAAVIEQLPDGVTCRAGLMKPQVARRLVKEYNDDGTSSVFESVPEAVLVDLPFRKLVFESRVLQRLYYGMDTSDDPSYAKRHISQNNLLLLDPIRLGACINKRLDSFFKMVSLGIGEKIRKLLARSTHPWLDDDFLYGLEDLQLELVQLRSRVETCESSADSAEDVANTIGEACSDVLTIAHKFDDDWGRVQETSSTIKRMCNYLSQQIAEVRNLFIPTAGSTNRMDANASAKDSDRTKAIKLFEISDRIAVFVLRTAFDLSVAKMKVMERRAELCQKPGAFSILEAEVFKHGIRTAEYAHDDIMQMLLLSHCVESYAVREWCARYFIETRLPLLGGMRNRFNLSGDSGTAKEESSPFFITAGAVSPDVSDFATLIPTSLSDYIREMIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV9</accession>
    <name>A0A061DAV9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767031.1">
        <property type="nucleotide sequence ID" value="XM_012911577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563386"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200020"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1712" mass="191430" checksum="F8B1A58597D95B52" modified="2014-09-03" version="1">MGFLSGFLSNIHKHLGQHKGEITEAIKSLEQNKHAGKNGFNAAIAEVVKGVRGYNKAVEQSNKKVDEEFKRSVADIFPEKTLSAAKNADVFNAVDQINEKLRHCHLSAEKFNGTFNFDKHNKTILNAVNDLNPNLVIRVKNSLSNVKHESERLKALSGKEKSDLRDILHHIRDILRECASCVNVKIKKDVEKLADYLKEKVEEILKSLERMRRKLTDHIMELGRWFETANSIIKVAENKIALLLQEAEGSNKNQIETAAVLIREEASELFKRFENLNAKYYGVFKLIKGENGKADTDGVLKKIKELPDQVKRGVWGYKWDDMKIDPVLQGAIDGLKNQIKLNIEAYVKGELPSELQLTLTKLTDKIAKRDDVRIKTLGHLDEVVKNLGTYAQDFPNTFKVKLTQMVRGIVDAEAVMYWLDAYVRGNTASGNRFTGSIGLSQNADIILPNVTKIVVDEVNAKLISVSGKEPTGTQKTVDGNLLEIHTFVGTYAGQVMNQLESTVSAIEGKLQENQDLRMNDPSSSTYQYYLKHAVTTILTAVRSAANGAKDDVEIFMSMSNIAEKLQKAIRDVKNLGSNMKDAVYQSSSGQLGTLGQSIKGDVGTAATNNEVEKQLETLLKTMGEKAVAKLQSELKAPVIDKLEGIRNDVDDLVNAANKSQSALFNKAQEVTSHVASLCHAIKQAAGDLDPDGLKNKLKDLTNLINTNTAEINGKTYKGLNKIHTDLGELRNLLLSDPIQKVQQFIKKEVTLVKAQIVTDLHRSVNNEVQSAIEKLTTEARKQYVTSVKGMVTAFAEKVHTELHELPAAIERDKHIGFKGFMGKMEKGLVSKVKYIKDINSSSSTLPSPVSKAARIVRDGVRDFVELFEKQEDIEIHKDTFQQTKNDFNNLLRHVEYTHHFDHMFTINLDDFEGVLRAFTPEIMDDPQRHLLTPLKRGLLTFVDELSKRYVNKYSGKKIQWTDTTNPKKGEEPTADATNCAKAFLTTLEILSNDFHTMLTESVKSWKGKKINTYADNVFGLWLEDRGYKVNAVEGEQTGELQDNQKMSVTRIYDLLNYPIGSVANKGAQPQWVNDIAQHKKTTMEHAYVINVVDVLHYLYGQTKTYYEVCHSRHIERPKSPSSVYQMLAWLTGLPHNRVFQKVSVGDIGDLFEKPDEDSKEAADGPIPVVDDETLKAHPDIITASNLSTNLRDVCVYAEDVLIGILGHGHADGIYAVDFNTNPDGFSYPTAPGACFDMLCDVLNRLYQQLFFLYGQCSNEEPSVSWRDCWYGNQVGGSAWNCNTMQCPNQKGNQIHKQKCNQKCDQTAQCGIKSPLQCFLEDGLPGFLPHSFSKPGCKLTCTLSNHGGIPCRTPMGFADISVTASHRQTGEYLKKVLEGFCGSESAPLTKLCAQLTCLLQKPPQTLGDIFAFYYGYITDYTGGFYGVKASQTHTQQAFREAVNAAYFGTQYGGLDPSILLDNRSHRDAHSKGDLISISSCTSASVVPCGLYVKSLTQEITRYYSAEHKANHLSWIVYITETFCDLLKKLYDDCCKKCGPAGSKCHVKSCVENCRVKYTDSTGKPTTLSPTHNHSAKCKSIVTCRDTHPTLYRYGFTFGHPWGLNGSGNNEGAKRTCRDFCEALKKMLGENSVLIQLRHQIDKFLWDIREKFSITVLALWLLSFLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLNKVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAX5</accession>
    <name>A0A061DAX5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0212160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768260.1">
        <property type="nucleotide sequence ID" value="XM_012912806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAX5"/>
    <dbReference type="STRING" id="5866.A0A061DAX5"/>
    <dbReference type="GeneID" id="24564615"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212160"/>
    <dbReference type="OMA" id="QDITQYC"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="48"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="30084" checksum="5D43C9400BC82ECF" modified="2014-09-03" version="1">MRLPWKTGRRIGTVTCVVLVAERQNECVKQQKTRRKEKTKVTQRMLNCVSNYERGSLWKRWVKTEEHRNALPRDIYRHLVAFDITELDVEIRKDIHRTFPQHTVFRDAKYAQDALFNVLKAYALYNPDVGYCQGMSFIAGMLVLYMNEEDAFFTMVGVMEKNDAKRLFLPQMPLLVRYCSVLDDYVRRKMRKLYRHLRTQDIDTAIIATQWFLTMFTYSFTLDAAALLWDVILARDGNFVVPIAIVILKLLEVGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ4</accession>
    <name>A0A061DAZ4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767076.1">
        <property type="nucleotide sequence ID" value="XM_012911622.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAZ4"/>
    <dbReference type="GeneID" id="24563431"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200470"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="854"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="762"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="938"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="865"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1915" mass="216534" checksum="F024D9B28BDF6A58" modified="2014-09-03" version="1">MAAKGNIPEFRTLKECLQFLEWLKNDGGMQGQVASRLVRLLKSRYKDAKQSDIESALSRFVGHVSNFHKKLCTFPRSYYNGHNSATRVLKSLLACIPKFLAVMYFLRYQVDDKFSAVGGGKWANLYPGWFQWFKVRGGELDAYLHDTSNENKYGVIPGGFDTSEVKRGGEYAQGFLMSDDLKSICEKHGRGFNVFLDVFVTSVFGDHGSDIPNVANALRLVEDFCKIFEDTENENAFRMDLESRGKCIDWPDLKGHCATLKKSLGKIYKEGAFSFTGYGREYTYLNKNNIDRKMAKWLKKHLHDVRSKLSRIVSQPDVNKFATTSLFPYGFTFYDNDFKNKGNPYPSLRGDWDAAIRELMRHNDGLEKLKTILDGNECLNRKKDKKPESKLKPGTQSEPEPEPEPEPELESSSESEDDLDSESEDENSSEPTNEITRIEAAKPVVTKAEDAKAETRMLSATQGKKSEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGGQNQNGQSEGTAPSKEVGKTSEAHTSTAKEDLGPPGSKGDQGSQGSSDPLSQADSTATNRAPSMSDSTADRHGGGGLGGDGTENRQGPQAEKTTSPVPQCSNGKISSSYLGGGNICFSMSDITDENIWDAQRQGMLENEYKALQEQQLQRQSRAHRLKHFPQLSRPDPSPYPQSTGLRYDNERQSIDFRRNVGQGEDGIQSDIYADGVAMDETYFDPQLTHNNADKIRLDGSEKLDHSGLKRQLDEEQRRQDAEDQWGKYYKRRDEVRAEMQKQGEVIKRYETEAENKYKSEARTQEIIERIRKQNDKKMEAAQNLDKKYEQTTQEIWKTQLQRNVEHIINSIDDPDAQNRLQQKRLRQQKISEHQTISAYPPTSTPSTLPSQPSRPDPGLTPQPTGGRNSNGRGYYELGEWRPRHEVSSATNMLPSDFIAFAIPDTSSKQLEEEKQKRAKSDKQRLKLKRRTEEMKFSDKQHDAWQKEVVKLGEANKKWKRQQKDVERLEQLYNYGKRQQEKRKAKETKMENLLGWAEEQNKMNEEAERKNQEAYEERQRQLQQLQSDYAPLLSGTPVADLRDFIPDGEAVPDESYREMQKEEERRAVEHKAYENSFHLQHAQGRDRLNTFLLENNERIEPNLASIDGVPQAVVESQTNDIRRIIDMDFAVHMSEGLDGGEIKDESQNTGEQEHQRNVQLAEYDKTVELQRDMQQQWEKYSQDQSIKTKRLQQEHIQEVQRTLDAIKHFKDVEYQKQRAAAESLSGQPIISKSISSLPKMPNYANKPTFSMATGAPIRNPNPHSISIPTAMFLAEPQPTRGLYIDVPDRPPPKFDDPEFFIEVAKHTLPDNHLDFDLDFDDDSTHIRNDTPPDLVDPSFPAISFNIPPPGPEQYLPPSENPKINTVEFKDTCAPAWITHKITPSSPYIPETELFPSQAPRTVRDMLQWLAGLQNRKHHDTLEKCIEKAFTAPHSDASQLALSVNHANIRPTDVFDILQLTAMFARSVLAAIAPNWKASVSLKTVKPKSSEEPDCCALLCQLRDYAYACHYQLQFLKAQCSRGKIHGGWQDCKYGSDITASKSPLQAFLTDNWDSDFETHPFDPCNPCLKSRVRMGFRKDDLPEESENGITLSSILTPSCGGEDPLLTLCSYLNCITRRTPRTTGELVSFFHNFGNELYGYASESLSSLGNSLSTPHDHCPDWDHLKNSDLQAVSGIRGSESLKSNSNHDNEHPRTLSTLVGCGSDSATCHPRCSPITYRAYALYSQSFAHTYLSWAVYLPDRLWESLQKLHYDLKKHVSIKCSSLHLCSTAPPLLYTHGFTPPEVGLQPPFTCQQIISKLEEIVNGKPIASLMTAMDAFLYGIREPFIFTLVSLCYAPLRYFVCVFLGLINTLHICGCNHFTNSSPTRCLLRPAGDAGVFTTLQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH5</accession>
    <name>A0A061DBH5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0202570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767286.1">
        <property type="nucleotide sequence ID" value="XM_012911832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBH5"/>
    <dbReference type="GeneID" id="24563641"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202570"/>
    <dbReference type="OrthoDB" id="366824at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="490" mass="55067" checksum="7969BCD9524B6D15" modified="2014-09-03" version="1">MADPTTDEKSDYLETPVSDIAYYADNAEYYRKIKRLETLSRPQAQLCDQLGNALLHIKHAKLRSKIREAKSKECLKLMHEVDHIGTLHGRYSKLRKMIDEYRALTRGLKRKNLTRERYAELQNALTNLEEQFKGIGQVTSGIFAFNSVAYLRETIRQVRIFIREHTDQRSTQSDDEGTRGLGSGKAAALESNTAGVTRGHPNDLYRNAPRSDEGNETMRELLNDGFLLETLGEAQAIAKNIEALLNDPVISDINFYAVGSGLDPYDATILNIQRDYDLYYDELKDLVKAWDIYERYAYNNDMLREMDLKSTQAFELLGEQRQLEVAFEEYGTLVDAKSLTTDSWDLLNMLHNLKWLKGKINRTQDGDTEPDYTTGASQRSEDMTSETISDDNASSPDPAIQDEATPTAEPNQSKEPKPTDVKEPTPSPVATDLQMIAVGDVTDELCGPQETGNFSKTMRNTKRDSDKSGFVAIGAMVVQIMVAASIMAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBI6</accession>
    <name>A0A061DBI6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prenyltransferase, UbiA family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0301680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768450.1">
        <property type="nucleotide sequence ID" value="XM_012912996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBI6"/>
    <dbReference type="STRING" id="5866.A0A061DBI6"/>
    <dbReference type="GeneID" id="24564805"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301680"/>
    <dbReference type="OMA" id="WCMIYDT"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="404" mass="45287" checksum="3791A0E4C5E0B8DC" modified="2014-09-03" version="1">MHPLYSHTSGILSQKLICSFALKQLRRHPFHQHGLFYTFAIVHRGHSYRNNSRCVWAKPLPSSLGDRDFARSLESKRYVSVNSVNLPAARPDDRPMRDRIAVYCRLMRYQALTPVAIFCYPAMWSAFMALPPVFGLEEMKKMALFCLGAFFARTAGCCVNDLADRNIDRHVERTKTRPLAAGQISTTSAVAIMSVNASLGLAVLMQFDLNTIRLGILTALGACCYPFMKRFTNYPQVFLGLASNISVFIVGSFFVTFLSLQRPGRRLCNLSPSPQFSFIRHPLFGLSCTTPCTPTKIRSMTGRSALNRWLYYGKGDATKRNCKISAVLMSLLIAAAGYNADLKEWFYGFIALSHMWMIRQINVVDLDNSNSCLKFFKRSVPYGTLVLAGIIAGKDLTFKTDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR2</accession>
    <name>A0A061DBR2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770194.1">
        <property type="nucleotide sequence ID" value="XM_012914740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR2"/>
    <dbReference type="GeneID" id="24566549"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404930"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="62" mass="7132" checksum="D875AF78ADA98323" modified="2014-09-03" version="1">MPMVVPNVVTWKWIVERQYNMHLLALGISDRINSHIQRDVRTTNPYAAMSNVIPIDDNDPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT6</accession>
    <name>A0A061DBT6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767401.1">
        <property type="nucleotide sequence ID" value="XM_012911947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT6"/>
    <dbReference type="GeneID" id="24563756"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203730"/>
    <dbReference type="OrthoDB" id="10322577at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="167" mass="19209" checksum="63FFF97B1F3188F4" modified="2014-09-03" version="1">MSTCDAQCNAISRFFTSAIYEARSLFTSGVFSFLEVMLEQVVRETVTEDNVKAAIKKPSVEQVMEAVVRTIMWYIWITYVVPLIVLLGFISALLLAAYVYGWGARCSSAFLKGTTITLEMIMYCFWKLKTLLYAFLNTYNEYDDYGLLSKFRGHRYLPAKFAKCKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ3</accession>
    <name>A0A061DBZ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770289.1">
        <property type="nucleotide sequence ID" value="XM_012914835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBZ3"/>
    <dbReference type="GeneID" id="24566644"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405870"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="134" mass="15687" checksum="66A3C22FA36C4F51" modified="2014-09-03" version="1">MIIALLRLAISICRRFGPRTLLEDSFFEELTHAGVAGATLHLCEYSIHMYYVAYKHYCYTYAETFKTRYTAHDYEKHSDSTSISKRSFCYKMLSTIYWLNRVLRVMEDPTTGVYREPSCLRGYRAQTITGVTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC57</accession>
    <name>A0A061DC57_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">-PHD and RING finger domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0401040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769798.1">
        <property type="nucleotide sequence ID" value="XM_012914344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC57"/>
    <dbReference type="STRING" id="5866.A0A061DC57"/>
    <dbReference type="GeneID" id="24566153"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401040"/>
    <dbReference type="OrthoDB" id="365591at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15519">
        <property type="entry name" value="PHD1_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="566" mass="62454" checksum="1B69BBDE1B08A656" modified="2014-09-03" version="1">MCDSWEVDGRLLAKIDEYFDFNHRQVSGPATFSDGPNGSFSRHKRARILDSPTDDVVTVNSDTSDDAASDREGSYEPECIVCSEPFTDTSDVGVPMSCMHIFCYSCIKKWSNHTNVCPICKIEFNELRRLRWRQFVDYLSSSTRWSLKRLRRTVTPRIKNFKSLKEHLLSCLGAVPSQREWVSRKSLGEETDDSVGGCEVCGGDNYWEQMLLCDGCNLGFHLFCLNPPLTSIPPGDWYCKECLDSELQPPQDSHDAVASQSNTASARTTGRRLSGSRTTRLARRSRVELDSPITSRHSSVESDSEQRPTSSAASSGDSIGLGSAALGRNVETHLEPVSASQDVLLDLGADFFSGDGVHPGEHESGSVTLTRMPPSLASRTSGSASYPFSLEERERADRRQERNTSENSIATNEETIGTECGGLFSEPDSPSAVEFDRNNGGRAGDSKEAVNETALTPGGSVGVIANGNAGSMHEVNVENLNLDDLAFNANSLSVQSSQNQETLDPASILGDMSMEEIDRLFEDKPKRCMSFIYRYRTMMEREVRGNGRIQSMQNPRIQGSSVRYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC58</accession>
    <name>A0A061DC58_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0205030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767531.1">
        <property type="nucleotide sequence ID" value="XM_012912077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC58"/>
    <dbReference type="STRING" id="5866.A0A061DC58"/>
    <dbReference type="GeneID" id="24563886"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205030"/>
    <dbReference type="OMA" id="MMYCHAI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="161" mass="18401" checksum="3E0BC159D13A2461" modified="2014-09-03" version="1">MSTFARRRIVQDISKVTKDPPDGVRVEPFAENMMVCHAVITGPKNTLWETGSFHLLVRFTEDYPTKPPKIKFLSRIFHPNVYSDGRICLDILQNQWTAIYDISAVLMSIQSLLSDPNIKSPANTEAATMLEKDRVTYDKNVLRCVEDSWILPVVTENVLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC68</accession>
    <name>A0A061DC68_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767551.1">
        <property type="nucleotide sequence ID" value="XM_012912097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC68"/>
    <dbReference type="GeneID" id="24563906"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205230"/>
    <dbReference type="OrthoDB" id="365389at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="349" mass="38226" checksum="CE600C78379DBBB8" modified="2014-09-03" version="1">MVSREYSCLFARNSDKKNKTWRDGVISVHATHRFARVALYEINGHNDTVDSPIDAFDLFHRDYDNLTGEIITSPRFIIKISGVDTNFRRKTGARNPPALEGVGSLIPAKRISRAPVLGTCRAFKKYCAQQDTKAKSLQTLPVALRSCHRGSDDLHNIANTGRCTEITTITSRNAYRAANQSAMGVTFTHSSSEAVHESLSPYSSKKIADTMPLSLSLQDAETKTPPSHVTSPKPTSARTFSVKKPRIPLNLPTIKALKVKCAAEKQLCRAGADFENGSPTEGCYDFQNVPSRERVVVSLGDEMMVSLLQTADEALGPHKNFDEVPIVDAELIGCIESALDHLGNLQTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC70</accession>
    <name>A0A061DC70_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BBBOND_0401240</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769818.1">
        <property type="nucleotide sequence ID" value="XM_012914364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC70"/>
    <dbReference type="STRING" id="5866.A0A061DC70"/>
    <dbReference type="GeneID" id="24566173"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401240"/>
    <dbReference type="OMA" id="SLDQHWA"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 18" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 18" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="20">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDR97632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="494" mass="54230" checksum="BBF348F97EEAD6F0" modified="2014-09-03" version="1">MAFICSISGVQPEEPCLSRTGYVFERRLIEKHLDENPTCPATGEPLTVADLIPIKCDKTVQPRPASAMSIPGLLSLLQSEWDALALETYNLRTYTSDVRKQLCQSLYEHDAATRVIARLIKERDRALQQVETLEQQLLEYRANYDAGAIEVGLDDDSVGRIEELAKALMAERKKRDVGVFTRADEIAQFRQTGDYRTHSSTTPGILSVALDEFGYTGGRHACFTGGADGNVIYFDLESGRTLSRLVSHMKAVNSVVSHPYSNIVVSGSDDKTVRMWRAADDGDHEYNCTHVVKSSKAPITSLSLHASGEYILACSSDGFWHLVELESGRVVRVCRDIPSVCSSVKFHPDGLLACGSGIDGTVHIWDLRTQEITSSLNDESGSRLNSLDFSENGYHLATVSDDGRLSLWDLRKSEAFASVDCNGSPSVVKFDRSGLTLAVGSTKVELYSLVDKTNVLSSGTLEGHDGYLTDLAFGNDSSFILTTCRDKSLRVFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF9</accession>
    <name>A0A061DCF9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIIS central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767721.1">
        <property type="nucleotide sequence ID" value="XM_012912267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF9"/>
    <dbReference type="STRING" id="5866.A0A061DCF9"/>
    <dbReference type="GeneID" id="24564076"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206930"/>
    <dbReference type="OMA" id="DFYKFEN"/>
    <dbReference type="OrthoDB" id="1742074at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS central" evidence="2">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="384" mass="43283" checksum="94BEA3CF13E1F6C5" modified="2014-09-03" version="1">MANKAKGAKRPKTGDNEMPNVKEIPEQEKQNIRDTYGGKFLECLQRGLTEVRKEEPNVDMNEEQLTTLSHRICDACYDFYGHDKRAFKQKIFEIYINMKRENNHDLRRKIITKVMSVDELIHAETIKLAPDEVQQKRQIEVEKHYLRNVILPGDQHNVAATAVDEPAPSPQSDATSEKAVSPSRSNSELDHMVSPGSREGTSLFDNESPGELQPESPREEEDSDPDGDGHENEYQSDAESARQSSISLSPKSRMSSSFEEAYGHLGDASTSIDEKGEADDNTPKRRRSMSQGSLTDDLDSSSIFFGRPHRVESDEDTTPKRPQPPDGSQYTLQQVMEKIEGRLNALPAYIAKPFRGPLKCGHKRVSLLMARSHILHSKQPDNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCU6</accession>
    <name>A0A061DCU6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methylosome subunit pICln</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0307980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769080.1">
        <property type="nucleotide sequence ID" value="XM_012913626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCU6"/>
    <dbReference type="STRING" id="5866.A0A061DCU6"/>
    <dbReference type="GeneID" id="24565435"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307980"/>
    <dbReference type="OMA" id="KSMMFHA"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="19561" checksum="C57DD2852E18DF65" modified="2014-09-03" version="1">MATFQGYQRNIERNVDNTPMLDTANNEQVHATYTDVILKFNNENHGNGTLYITTSRLVWIACDTSTVSYAFPYLGMVLHAVSKDKALCETPCVFIQLQGDSADDEEGDIPVVILAPAQAEQVENIFEGISQMNSLIEPLVSQSEDESDGDEDFDEDSYDEEDAVEVDEHVQEQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCZ8</accession>
    <name>A0A061DCZ8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0405860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770288.1">
        <property type="nucleotide sequence ID" value="XM_012914834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCZ8"/>
    <dbReference type="GeneID" id="24566643"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405860"/>
    <dbReference type="OMA" id="ERQHAMR"/>
    <dbReference type="OrthoDB" id="385236at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="176"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR98102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="461" mass="53033" checksum="75FA625870A4AF77" modified="2014-09-03" version="1">MERHAGDAHLGGESHSPEHLVHENNGHSPYLDPIGMNKQCVSSSCTTMCDSGDENQNPNQHGGQLDCGMLPQNYQMNYGYPPQYDNFDLATFINNSFNKKDGGVISGVKFQPSDNRWIARWTTADGKRACKSFSVNIYGFEQARALAIEARQKGVSLSGRSFCNRERQHAMRSGVGIIGIRFDKTQARWVSSYYEGGKRKFRYFTVKDYGYEQAKQHAILWKTCNDERLIRNRVQHNEVMDFKMAEGPMEQVMPPHQWNAQPFQQPYVGYYQQPQMDYCNPQNECVVQYDQPQMQQSLIQYKPSAISGQQSVEARSPSLSTSASVSGYADPNEQMCYNYQSDLPYQYSHQQYAYDQQQQMQYMGEEMDQYPLEHEHEEDTCSVSGVTFDRKNRRWGARWTTPDGRRAGRYFPVRQYGFSEAKRLAVICRLQAIEENRGVDIMPPLDLNMQQSCGEPVNDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD23</accession>
    <name>A0A061DD23_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769225.1">
        <property type="nucleotide sequence ID" value="XM_012913771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD23"/>
    <dbReference type="GeneID" id="24565580"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309420"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="127" mass="13912" checksum="C0524317146B32AE" modified="2014-09-03" version="1">MSRGMDWMNCTCGTSCKEYKCKCNCCQQTCKSQEKPGTCSPPAPPPTLSSPGVQDPEASLALSSPPEDEPQENNSHFSPDPQVIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF3</accession>
    <name>A0A061DDF3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769530.1">
        <property type="nucleotide sequence ID" value="XM_012914076.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDF3"/>
    <dbReference type="GeneID" id="24565885"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312470"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1650" mass="182014" checksum="1123BC30EA452B44" modified="2014-09-03" version="1">MAAKSTPSVAGHGVKLDTLRDCLQFLEWLNHTKRSGARTQLAGRLARLLEKKYNDVNRNQIESALSHFLNEVSNFYKKLCNRADHGTQKPQTAIRTLNALLECVNKLLAAFYFLRYRVDGGFKAMGGGDWKDESVGMIALYAKRNLQVDQIRKYANVIDRYFIDTDSGEYGVIPGGFGANELKDSYMLPHGEGYASGSEMAKDLGNLLDKNRHVNNLFLDVYSTTVVGNHGTDTPNIANALRLVRDFCRIFGKVTDPQDFKNHLYSKDRCIELPQLQAHCQKLIVPLEKIFREKRFSFTGYARDLKGLSENHIAKKMASWFKANLFEVKEKLKRIKTLSSIKNFKNASFQRGAVLPKNAKELADYFTHNFFPYGFTFHGHDFNKWTNAYQILTQDWNGVISDLNREGDGLDKLVDILNGAKCRLENEKRKGKGTGTEQVKAAEEADDGEPDPPAEDSDVESEDEKDEQLLDEDLPAATKTEAAKPVMTKAEAPKPAAPKPDAAQNQGKKAEGAQNQGKKAEGDTSQNGQSEAKSPSSRVSQVVQTQPSSNSSADSASSGVADPSSGQGPVSQAGSADAGQPGVQKAPKRPVGDTAAPTDTASGSGSVGAGGGGDSGENGHNPVKKCLEPNIENLWNHREGKTALEFCEVKYKKPSRVPINGQKTPQQLWDDYEKKKEEEERKTQNAYNTYVRQMKQMPNYSSALNGSAVNTPFDGTAISESSKVSRQQNNAEHIQQTYHSIIYNQQKSDKKMHDMIQKSVQRKKDEDTQWIKKRIYGSHELAVGGIQTTTPNHHPVDSSLFDFEKPIGRDVSKFPEFTTNIIDDIKSKVRPTQSTDYATGYATADSRGIPNFTGLQGSFANGIVMGHPIKQPKLPKTYPPVPEVLGLTVDAVPNHKFVRSPPLSGDPVIPPSQSAEHHSPVPTQPEPTLTTMYISGSEINPTSIPTADIPTDFRDFNSLVSEPIGNPISDPNIGRRMAPIDSSNLPWQRAHAPDKSPIKVALDQTIEKMLNVSTTDLTGSTKNDANVPAPQKIDPPVPPSLITSWTIPNTEKRFPSPTFPPSQLPKIAANATTTKIPHEEIAAYPGEFYPLVSEATGDSISHPKHFSPTSPIAISKPTVPPLPTKVYPPHSGQFDDQFMGSIPDIHGAPITEDTNKIQMARVQDTLDFKLSLPAEPMGHPIPYDNKDPPVQGPPPRFKPPDVSGSVTTGFIGGVESWRKKEVMYNNIKRDLEAHKQALANDQDRRIKEAQRYGEGFKNMVHMHDDDRNQHLLDDVQESTETLKFPSPRKLQNILYPNEKPYVAPPVIETLPHGLQSTEATGDVSKTFIDVKDSESLPEVGLSVDVLKHSPFQPLNDYDYGRTLMPPPVVAGVQLASTLDSARLVSERSIPLFANPHLCTDPWSVSTSASSTDTVQPPTSPPPAIDRLPPPKTVREMLCWFVGLSQYGLIGVVTEHVYSLLRELNKDTSHPTDAIDVTGDLSTLDASMVTAKLTEACLYSATVIYRIKHRDDYAAYKKFKFESVYSNLHYSPDPAGLLCQLRDYVYACHHQLEFLKAQSSRDKLSGGWENYEYGSDITASKSPLQAFLTDDWGSTFETHPFDPCNLCLKSRVRMGFQMEDLPENKQTGATLSSILTPSCGGEGHDALVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ5</accession>
    <name>A0A061DDJ5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768486.1">
        <property type="nucleotide sequence ID" value="XM_012913032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDJ5"/>
    <dbReference type="STRING" id="5866.A0A061DDJ5"/>
    <dbReference type="GeneID" id="24564841"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302040"/>
    <dbReference type="OMA" id="PHGAQIW"/>
    <dbReference type="OrthoDB" id="366771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596056" evidence="3">
        <location>
            <begin position="28"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1109" mass="121712" checksum="4FE4FEB52B4D15C0" modified="2014-09-03" version="1">MVSTYQRFTLSWALLTSLLICCGLVGAQFDPEDTNDRPISWRFDASPVRPHLNPRNMEQRDEMQRVGAVADDAKRYSVIAEDALKLVFPQSSTNNFHVTKLLFDKNYANNDINVDLWEKISAMVKSITDGYNKIRNAVFHPAAVKTVKTGVFQSATVMQDFYGYQEMISQININHLRKYLDDLISSSQLYMQLKMFKALPPYLLNEVEPFMLIRKLSTVYSITGVYNYTGLISEALKAFTDAESPESKEYKTWINHQRAQLKELAALLLTYDVDKAEEACSSLQCMGYTNSANVALWYELYSAIDEQTVLMRSSDELKTAIHLTLARRGNTYYDYCNLSKIACILSSLLPQRVMTQEERHEFEANMNRLRASMMAAGIKIDASAPTATDESIVDHFDPTAPINASRTELTLFIVYTKSMMRNIVKSQKWIRDRLYNVANRKIIQRESSGMDDWRTEFDRLRDTSDIIQDIIGASKVLNDRIDVYIDKYLTSSANEYITEYGGYLILKKAHRVMSNTSAVRGLMLDFYARLNRTFVAREAQMKLYAYPSLLYEVANLVSTSCRALNAYLTPYMELIGAVTMDMAKADAALSSAPPSVSSSDRFEHMRARYQSLKDDVQLVLNQFGDLGVNAERILGLLRFVDGNAVSESEDSREQLWYSYFELREDIHNGILLGSAFESIRYKCEEISKFADELAALVDGDGGSGEASRRATAVPGESTEDSVSGDAASSDESAADGPVDAASVAGGEVVAPTEAEHGDADGSLAESDGRDGADEATGSVPSERAQEAVSASTNDHVTPEPTFGMPSEESYTTLPDETKATPQPTVDMRSLESYTSLPDETKATPQPTVDMRSLESYTSLPDETKATPEPTFGMPSEESYTTLPAYEEGVYEPATGVFRLSREDERTPIDGDVSTGTTAADRATESTTEKSAEELPRAFGGVEVPRGETPGGEVPAMWGQSDEETPTDSSATREVTKASDSEIRKNAPTADQSSSEDPSGTETAAIASEVEVAGGAAVAGEVEVAGEAAVASEATVAGDDWADDDDISPSTPEASGRVTGVDEVPSEVIVLSGSVDERGNLRDKLSSGFGAVCVCVKAVLSLFLWAVLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDL2</accession>
    <name>A0A061DDL2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769705.1">
        <property type="nucleotide sequence ID" value="XM_012914251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDL2"/>
    <dbReference type="GeneID" id="24566060"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400140"/>
    <dbReference type="OrthoDB" id="10610028at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="25619" checksum="7AFCD3729FBDAEB8" modified="2014-09-03" version="1">MTPFSDSALCAPTPKPSVPSGGARAPAATPAARTTPESKTSQQKLFGLNGYGHVKSEGVTKKPRVDAPPPAAVPSHRPAEAQAQAAAPGATQPTQPRVERIATSAPGESAANTHKDFQSFVSQKLAQPSSSAAAPSSQVAPAAISQSDALEGSLFECDDPCEAMELDDASCNDRPVSYVEKVTRDNTYVDSGYFVVEESDEYVQVNSPARGPTSAPLKHGREERSSEEASEAAPPDDADVSSLLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDL6</accession>
    <name>A0A061DDL6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768546.1">
        <property type="nucleotide sequence ID" value="XM_012913092.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDL6"/>
    <dbReference type="GeneID" id="24564901"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302640"/>
    <dbReference type="OMA" id="DEILSWH"/>
    <dbReference type="OrthoDB" id="366880at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2990"/>
            <end position="3011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2232"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="540"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="716"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="935"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1829"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2232"/>
            <end position="2243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3063" mass="340472" checksum="A38BFCD0B7F0949A" modified="2014-09-03" version="1">MAPKVLTDCPENLREAIDWLVQVKHCGGVSTLSDALASLFDNVAQDAEESLSSLLDQDRPSARDVSKLRAFHSTLPKDSENPHKNIIHNLCASAGSLLGYSLPGAYDGSGIVYGNASRLCDAILAFLYAVFNDVYGNQPYVAGRNVLHDDLIVYLESQLWHGHKGFCQAIPKVATGLQRYNAAVEASNDKVKKAIETVLDYVKPDGELRKGIKALQISETSTSTQDERTVDAAVTLVEGCKEVARVFSKSLTAATDAIDDLNPKLKRKLENARRSLFNHVEWLSRWSKKGEKKRLDEMIQKIKSRLRQLAKAVKEKIKQEVHTVVELLKERVREIKMKLQGITASLEEYVKELGQWMGEAKEYIKDVKKYVDEIMQQLDGDHRQAIDKAAADIDSQLGKRVEELNQWIKDAEAAVTVAKQKADEVYKRLDKNSGTTIAQGIEKINEAKDAVSGVSTQLETVHKNLGDWKSVAKDVLSKSLQKVGEVHDKLDPDQKTGDHPIGKNLENIETAQKAISSANLELKTQVDKLSNWISDADRIREQAQQKAEEVYKSLEVHKQLSEKIGEIQTANKEIQNVHSGLNSVEKNLEEWNQEARKVIQSVVDRVTEVHKKLDDKDPGTAVGNGIKQIKAAKANVEAVDKGLTSVNDDLRKWRGAAEIVLSTAVDKAEEVHKQLDPTKNSSTLGGQIDAIDTARQGIVDANEQLGAQVKTLQKWIETAEDIRHKAEQKAREAYDKLQVHEKLSENVKKIVDAKNKIDEVNKKVTGQLGSLKQWNAEANKVLEGAITNAQYVHDELQSAVVQKVEGIQQANASMIEANKKLATEVQNLGKWKDAAKDVIKKAEDKCDEILKRVQTDPSSNNDSIYKQAKLLRDSGKKLLTAATDAKQKVESKVKDALDAVKEMDTDLKRDLYDVKEKIKKGITEVISELQVGALGDRVKEDLKKLRGNIEGLKSKVDERNGNSIVKNQLNALEEAKTATINEVQQKIKNAASDMDAKFRSEIKGPLNEKVNTITKAIGNLYEKINPDSRNASEDDKKKLHKIFEHIKKQVADIKGKEGRDAFDSNSKGLDGIVKNVKVLAQQFNGAAQFGHKVNGFVLEILRDNMIVREMLKKYAQENVLGNDYIEPRPDKKDSLFNIKIAEMFKDTLKGEADSAGQKVQELFTKAQSHPTIQRYINAVKEGLTTFVDEVEKNLKVIEIDKLENSINSRVDSIFNGIVNDVKGKVQGGKITHNDELLKLAVKRILMKLIVIVRKVAGEVRVLGISVFGKILDEIKPTVDALDKNLKAVTPSAPATGTAKSVDNAIEGVSNEVKGLDTKFQQKVKKPVEDAVNQLEPAVKAFDDKAKGQVKEAANAAIDAAAKQFADSSGQINVESLMNNFSSEHGKIQTQLPNNLRALLDTHIGTDDRASGKADTVKLSSDFVNYGKHVSTGVPTNRIHEPLAAAIGKIEGVGLAALNKHIGDGDKIDGQTFDGPFGNIEKELKGIKKLVSHGGFWGNNDKGVKELLEDLRTGIDSGTMDGASDKGLTNIRSAIEVLQKGAFGPRSVAIGEAVKEIKLKLNELREKLKSENDGDKDAVINALKNLQTQGLGVEKWNDKSGSPVNGLRIIEDDLRKQNEELGNQTMEIGKAFDYTLRELKGMLGQVGLRLHNIIVPDDVVDNLKDLKLKIGRGKNIGLERIHELIKTLQEGDFKNKPEAIEKARKELEAELTKLQKVLQGNKHDGGIETLKDLKDVGLGSGKWEKHGNEKGLAKIENELKAQLDELSVQRDFIDLGMTRITMVFDELRKELKDEKENPNNGVIKRLEDLSEKGLGKDAWQNGKDGLGKIRSNLQAQNTQLSQTSKKIEEATQSVMDLTKTVLKSAKQTLSDEVANDDIVDNLKKLEEKIGLNGNTDESLQGMKNKITDLQSQAFKDNTLKILQAKDEIDAELKKLQGNLQDDVSSKLTDLVDKGFGPGDRWNGNAKGFDHIQDNLKTQNNTLSQQPKKIQDGINEITEELQSIRDALQGTADDDLKSRGVIKNLGFLTTHIGEGEDKGLKKIKSDMDSLKKNKVPVITKHLNTMSTKITNAAGQLGWNLRQLENPHIDAKLKGIETGLDNLRLTDLAEAIKLCDDFLDKADEIERNTIHALLKHIDDEVDDAINDLTKEARTLYVDSVREALGLFATKVNEDLEQLPNEMNRDRCVGYKGFMKYLQSPLSSDLTGDEQSVAELSSAFQEVFEQIEKYVKGELTRLHDEQNKEKNPSLPPTEEPYTAKLNDVYEALTSVLAYLKDNDDGADKLTEMVERLTKALGNLVPSDFKHTSTPLLDTVARGLTKFAGEFSNTYISAYSGQRCREEHSHKYAKVLLSMIPMTHQALTKLATKCESEWKSLHISKLTADYRDNALGNYLTRCGYRVSSSESGQDGELNHRFSGGRIYELLFTPMEGVAIEMLVDGEPITNGINLVTIMSLLYNLLCRYLQVCHLYVPPEPRYPCTVRDMLSWLSGLQYTQVADKLPDHCKALLNHRCHDDDTPNREDPVMAKCIGELPLTIARTCSHSTALLTAIQGNGHGFDLAAYPYSVDFSNNRARFHYPADPYALLDMLRDIICRLCKVLYFLYSQCCRSTARVKGWRECAYGRQVQSHRWQCEQFGTYSSTISTTTGTSTTTTSTTTHGCPPTSPLQSFLSDRCNGLLPHTLTIADMVIECANCAANQPGQQCLTPLGFWDLGFAASISGTGWDLAKRLADMCRDADSCLFVLCRTLFLLCPAAPSSLNDVFALYAQVLRKWDSHDHVKHRGGTYTDASDLISHLNSDGIDGLFPLWTQLHGSYENHKLTSAIASLAGHDHKSHDALSSLFNDSTCKSPSGCAPYLQPLGLHAHHTYPQKHAGPYITWIMYLAWKFWELLCELLHALDNVDCTAAGCATCPCQPGTHGGKDTCHCPSIVQCAGPLPTLYRYGFTYRDANLLVTENYAMRCGDLNAQLKEALHSDHFTELFRQIDQLTWHIRMPFLYFLIALWSLVALYILHTFLYRMDVLYIRSHLLTTRTSHLIDVKALLIQNRKMLSLYDASYFDDDPSELLDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS5</accession>
    <name>A0A061DDS5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769840.1">
        <property type="nucleotide sequence ID" value="XM_012914386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS5"/>
    <dbReference type="GeneID" id="24566195"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401460"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="78" mass="8713" checksum="5DFB9E925A93B564" modified="2014-09-03" version="1">MGTILRQKIVAGIPAYATDLASQNSWGHIAMHNLWNNCLQLFICIFLAVTGAMRDTSLPAHTVCDMAFPLSVYYKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDW5</accession>
    <name>A0A061DDW5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0305380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768821.1">
        <property type="nucleotide sequence ID" value="XM_012913367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565176"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305380"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1877"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1947" mass="217503" checksum="2C14609E71E6D38C" modified="2014-09-03" version="1">MAPQFKKLTDCPENLRESIDWLIQVRHGNGMDGIGELAKALQKLIGEAIEKAYTTNIDALLKLLDSAKSYNCCKDKVAEIGKLKDSEKIEDESLKKLLQCVEDHKTSCYNHLDHSQQKSYDEIESKLDQLKNHKESLEGLTDESQCKVLLTNLCDGLETFLGYDSKSKGYTGQGIVYSDLDRLCDGVMGFLLGVLKEVHENNNLSPYKTTLNEAVTKLKEQRYNGKKGLVAVIDPVKQGIAGWLGEVEKRNNDVTKYINFLQNDAINAATGIEKWKNQAFDEASKKHGELHNWIKSIKALSNQPYYAIHALEYVDKNLKNDLLPHITLLNNAIDTFKQNTVEDYNGLNAVASDAKFQINALENMVKQVAVEQQQICRKKLEDAFLEKIQSPIEKLNEKLKGLNGELKTWIDKAHLLVSKATAQCERIVREVQDQGHGKQKSANRTAVETAAETLRDRANVLYKAANNVTKNIDSWVRAAQSQLQQLEDAVMWDLNGVKDNLLAGFGKYLTGYVGKIQQEVKKITDYKTGLQKIEHAVKAYATDFKSEEGFGTKVKMWVEEIIEDSAYVKEKLKAYAGSKVHQGRFRQPQYTASQPDIAISKFYQDIAEVFKTMLRAEIRDAALMVQQMIDSDGGPAEKIEDNIVAIHTGCEQFASGIEAAIEKKASGIMNPMSAGFYTFAKDIAREIEKVVLENPARPDSLQLEDSLENAVRYTLAKLIASARQKAADLGWLTGEDNNQANIGKVDVSLDVATKLNEALRTATDPDSSTGKSYVEDKKALADYSVIQDISQELERELPLAIVDGSSTNKVQLTKFTSSFTNARPDGANETKKKLLTEKIKEIETKVLQKQHLGQVMSTTTNGATDDKFYSDTFQKLCEVVENKLKTLCKAVADLVTNKGDENTITPDDKRGLQNLMADMKSMLDEKYLDGKFYKLPNRLRQIQKRLNGIIGTEDDYDNSETLVGILDACGKFCGQTINEIVKDSITQIKTTVKVEVASKIASIQRSALANFAKSKEAELHNLQELIKDKNRVIAKIIRDDLESELKGMMKKMNAQKGTLDTIHGLATPSPGTPVKDNAQKFRQISTNFKSYYNTIHEHIEDQLIPKPKSSPPPPPISGGGYRARPAAPIPQPKGNPPGRVGMSAKTAPTGQQPPQTTKNLIAEYIERLKVHSDRLFGTLSAGYFSRSFATKLENLKEFLSSMRFSNFAGIGSPLFDILRFGIQSLTTELGKAYISVCDTQAYNFQWNVDKNSENCAKVFVTILGMIFEDLSTLKTECDRRFSISTISLSSDLGGLFKRYGYVVAKDSKSQDGELRRSDEMNGTAVRGRIVGDYPRVFNSSADTRHAINSLFDCLETYNQVCHLSTFYAWRQPCSVYEMLVWLAGLPYNNVYAVLLSDGLTNVLTKPKRKPIETGEDDFEVEFDDLKAYYADTYPNRVTHGDIIAALGHVCSTSYDVLATIAGHGDEFTTYAADFCTNSLNLKYPASGEECLHNIVDILRRMLPQLQYLFSRCKLSAMHGGWSQCLYGKDVTTTKWPCNNHSSDKPSTKANCQPTSPLMSYITDSLPGHQPHQLSSIGCKYDCANCPSVSRKGMPCLTPLGFRGFSGSTRKGEDICEILEKLFSNFYLSSLFCIVPKTPASLPEHYGFVLSLVEGWHSTKTSRKGLIMESIETSIGKQSIGLYDDTSKLTNALANAYGSSQTIHQDKNHLGPLVDLSSLSMNTVCQKKDAKLQCAPYLTSLCVDAYIYSTQKQSNTYLSWAIYLPWTFWDLLNNLYNAFCSINCQDWACRECLRGDKCKKGGHGVVDEDKPNNKCQCPSIVDCKGVAPTLYQYGFVFGEASTLNDKASPKTCSDFCSQLKNVLNSEYFKKLFRECDNFLYYIRFPFMTLTLALWLLSLLYLFHIMIIRLDLLHIKSHLHSPSSHRITAQSLLAAARVGKLAKLTYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE07</accession>
    <name>A0A061DE07_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Immune mapped protein 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0403370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770035.1">
        <property type="nucleotide sequence ID" value="XM_012914581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE07"/>
    <dbReference type="GeneID" id="24566390"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403370"/>
    <dbReference type="OMA" id="KTMKKDM"/>
    <dbReference type="OrthoDB" id="360347at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040955">
        <property type="entry name" value="IMP2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18590">
        <property type="entry name" value="IMP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immune mapped protein 2 N-terminal" evidence="2">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="225" mass="24563" checksum="F7354D9C422A0208" modified="2014-09-03" version="1">MDSTEGEKLSARSQSGAELDSQSEKNIDSARSGASETMPAPAPAASADAGRIMRADSAAAGFNALSASTPVCYCVYEEVAQGTFYFQWKANTQEPINNHVMMFVPSKTVPKFKLVNDGGRSELATRVMPDKQKFWSSLCLFIKSAKEYKAKLQLFPGWNDIVPYKSDIYFHNGTNTVTKVGYEPIDLEDVAAIGIAGRANLLMANKMSKEQFSQGVRKGGYCLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE15</accession>
    <name>A0A061DE15_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0403620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770060.1">
        <property type="nucleotide sequence ID" value="XM_012914606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE15"/>
    <dbReference type="STRING" id="5866.A0A061DE15"/>
    <dbReference type="GeneID" id="24566415"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403620"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="94"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="290"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="465" mass="52678" checksum="FAEFD347AD6DD586" modified="2014-09-03" version="1">MTPEKSPEPTVTEPEEKENVTKQPSQVETAVEIEQQKPKHYHLDEIQDAIKVNGVYAEEQDLEWTDLMLSPSLLRGVQHKGFIKPSRIQQIALPLITNSSTNLIAQAKNGSGKTATFSLALLSCVNENMPAIQGVCLCPTRELAVQNVQVLAQLGKFTRIKYFIGVPQCVPYGRGEEYHIYVGTPGKTLEFIRKRTIDFQNTRMIVLDEADELVNPDNNMGPQVMQFRLSFRHPVQILLFSATFSEEVQKFAQRMAPDANMIQVKRQQLTLDCIQQHYMVCSDDDDKFNKLCELYASMIIGQSVIFVNSRNTAFDVSLKMREQGHAVSLLCGSMSKQAGSNSMGPEIRDRIMREFKDGETKVLICTDVLARGIDVPQVTLVVNYELPFLYSGSARFSRDRKIAMETYLHRIGRTGRFGAKGMAINMINPNEMYLIDSIKEYYECNIEPLECDPESIEDLLRNIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE71</accession>
    <name>A0A061DE71_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0307840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769066.1">
        <property type="nucleotide sequence ID" value="XM_012913612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE71"/>
    <dbReference type="GeneID" id="24565421"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307840"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="7784" checksum="2178068ABA401C0D" modified="2014-09-03" version="1">MGGGKPGQPCWSERKEHDWRKALSTRIVDVDGAVSHLNRLFVSVMGIQEITVAVSETVIHNQSTTHQKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE75</accession>
    <name>A0A061DE75_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0405230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770225.1">
        <property type="nucleotide sequence ID" value="XM_012914771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE75"/>
    <dbReference type="STRING" id="5866.A0A061DE75"/>
    <dbReference type="GeneID" id="24566580"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405230"/>
    <dbReference type="OMA" id="WKPTISI"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR98039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="162" mass="18540" checksum="2FCEC30DF08CC746" modified="2014-09-03" version="1">MTTIARKRLAQERADWRRDHPIGFSAKYSPLPDGSGLDIMNWICKIPGKKGTIWEGGEYTLTMEFTDDYPSKPPKCKFTPVLFHPNVYPSGTVCLSILNEDKDWKPSITIKQILLGIQDLLDNPNPLSPAQADPYMLFVNNREQYNARVRKQALENRPTDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA9</accession>
    <name>A0A061DEA9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769171.1">
        <property type="nucleotide sequence ID" value="XM_012913717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA9"/>
    <dbReference type="GeneID" id="24565526"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308880"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7562" checksum="63F465289E4FA6C1" modified="2014-09-03" version="1">MTKPCMFGHTNCSNKTVEAVGVGIGIGFIVFPALLVLVLYIMGRLYNVSLGEIFGQIRDGFRDSKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE5</accession>
    <name>A0A061DEE5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769326.1">
        <property type="nucleotide sequence ID" value="XM_012913872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEE5"/>
    <dbReference type="GeneID" id="24565681"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310430"/>
    <dbReference type="OMA" id="DSEMTIF"/>
    <dbReference type="OrthoDB" id="41566at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="743" mass="83151" checksum="6D1EFD89DC23BD96" modified="2014-09-03" version="1">MSVTPDISDALEGVSEEDARLIVHLTWLYGGYSMRSRKKPSTPTRDTGESELSPKVARSKTKASPVKTERRTTSKSTRPKQDEKNANGNKPEKQQTGRIDDAKIADVEESFALGDVDNKTKDVDTSLNGLRNGWQNGPDSQSTEATEASSGSGADLLNDEYYYDYFVREKDTMILDRRRPRWANGLTLKDKINRFFESGVATRTEVCDGTPTTLSICNQFELSNHEAMVADVDRVHYYRAAIFWSGYNTSDNSEAETTTSALVQTDFEVDGRKHSDHFEAGSGESGQEDANSPHPTTRCNSGELYPNNPLKSYCADKRVLEIGTGPMCVLAMNALNAGAKFVDALEVSTSAARLASKLMAAYGVSDKIRVFNCHSKNFFFDTASFFGLKREEYAGMTEIDLPANPPYDMIISEILGDFCSQEGVADVFLDMQRRILFNKPEYLSKVKSIPTAAATMFVPCVFPDADNVVNKASLHDEMTIFSPTLKMLQSVGLRIDNLPLCEPWQVLEQLRFEEWMQPQMCQHFESSFTISSSGPMCGFLIGIDVEIRPNEHFGTKFGHCESWYSNILLYDKEYMVYSGDVVLTRSIANLTNYVAANCLGDKIDVSRPSYSVRSYILSPVNSSDWDVEDDEVFNYTAPFGSRRMKCPCISDAVPEPVTKVPVNSLAQLSRDVVNSECAEPEDWLSNYQWVRIGDNLYKIRIRPHAITIDYVEQTSASFSQVPSGKRKLPTDPPRRYKLVKPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN6</accession>
    <name>A0A061DEN6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formin homology 2 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769781.1">
        <property type="nucleotide sequence ID" value="XM_012914327.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DEN6"/>
    <dbReference type="GeneID" id="24566136"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400870"/>
    <dbReference type="OMA" id="WPPSYKR"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2051" mass="223064" checksum="80AC1A347BA34A9F" modified="2014-09-03" version="1">MVDRDLGAPKAPAPGAENISFTDAVSSSRMVSSLLMNQDRNIQVARSFTRWEQGRESGASNDNNVNIFDSMVVETDRGYAAQSSPGSATNNTCLTYGNVMRRGSHANTSEIAEAGTSRYSLSTLGSSRGKQRGNSTPSDADSSMSSDIEINANMMSRKTALGALMRDRGKSVQRAKKMSANALDTYKAPSRLTSPRQPKTSTQPNTVPVAGGDAAAADNTTHRPPKLTHGKSPANLNETKGSTSPGKHEEKESSPTPGDTSSTNREDLFSKIKRAVTRDLSDDVRPPLIHSFANKILGMRTPWQLPMKERSLRNNVQQLISFFRVLERYVEDQVYRYGPSLHPRLDKVYNDVYAKIDQMFKKITDKGISQVDEPRRIAVVGNEVYDIGDHHPRGSPIYYQKFVIFDLSQDSSNFSNEHGDVFNRQVLSFPMNSRGLPSMSYLCSVTSAVLFWLDFYNRDNLVIFNYAALNYNMLLTFACSILASQPVATANEINQMITNSFDWRKKCRKVASGAAKATSDQMHQSELPQMIPIARWPPSYKRYMSYFLSLYATPVDFVVAQQFKLRHITLINCLLPGTDVTLEVYKVGPDAVEAANFQKRGNLECSKECARYSAVFYPKCACGGKERDGAMLIACSADYTVVSKSTKSKSGKHGYVGEVRFDFSLDAEGNRRNAVISGDVAIALIAVSMKQRKVIATYSFNTGFVSSDMIEVPKAELDIWDTSCAIQPQGQMTIAMESRPLYSGDSRNKSIPPAVITPPTSDVGVFMRHHVAKVSSDDAKALVNATGLSYDTCAFALKLCPRYIDAMAILSALFVPKKLKVEMENNLYRSPRSPTIEIPIVASLDSPRVDSARIYSPTGGLSRGYSVILTPGTSIGGMAPISRIGSFASGAGIGIDGGIAGYDVDPRIGLISTHAGAANRMGLVSHDSGLRPDTEGRDYFTDGNLGDSVDIGTPTGRRSRIARAACRSDPEALYDGGAEVGGIRSSHGRRSRVAGHTSQIADDLVSDSDGEAVEVGTVSGFSTRISGRRTHIDNEAIGDTEAVEVGTPSGFRSRISGRGTQIDNEAIGDGDDEVGDLGTPSGRTSRVTRPAYRIDNEALYERATEVGGVATSRSRSRIARGTVEIEGEATGDNGDEIVYIATPSGHRYRVPRSVQQISNEATDGMGSELGSTATLARGAALAGGVVADAATAMQDGVHATQLGTGSLKQDVGTRLRIATDVGKLGVETQAGIDNDGRIGGAYTLSNDSTVKIQRLANLKDVEGAESLTVDQVERILVESDGNMQLLLVDGTTRPVPNNSVSSLLQMFGPPQSHPYDHGKLVSQDGVPGGAEMLKRGGGIPSGAYPAKLASKAIPQGVPKASPPPPSADKAKSPPDELEPQAAATSPDAPVVKKLAPPKAKTVPSKLPPPSSKPKGAPAKSAAPPMKKGPPCKMKAAPPPPILKGKAAVAKKPPPLGVRLHWKPLNINAVKGTIFENLPKPSAEDKLFDSTLVKQLFSKATIKRQLTMKAPELKRQLLKEILDPKRAQNIGIILRFNNESQFDELIDALDNLKLDDPIVNIDNIFKIQSALPQGPEVSAFTAVLQSKADLSEFRDVEQKVFKIVKRDFMDDKVKVAHFALNYKTLLESINNQLGAFQRANEQIAGNEFLPIIMGGILQYGNFVNHGDDTVVQTPGFSLSSAIKLIDLKSADNSLSSMHYLVVNLVVKFPDLDFATFDKSLHHVFEAEKISANGVDELFDEIRDGLNFLLRLVERVPQDTVLYRKTKALIAESTEATGIASERHETVFEATRTTWRFLGEECKQGTSLDEIFRILADFMRCIKRVMNDIQQRPSKFIVAINDEEKRELYNSKFSLYFRACCGGNMEEDEGVDSDLELGIALSISQQASSESERPVLKTRRRRLLPPVAVCPRSKKLLRNVCLNDRAAARRIHGIIDAAFKTLHAVGDAEGDPSDPLDVDALELALLRLGFAVDEAQLQDMLRCYQHDGTAPASSQLAEFALYTRETVGNRNVESEWRPKGAGSRLPIERIDQGTFRDIFLDCNLRMENNGLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEP9</accession>
    <name>A0A061DEP9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769846.1">
        <property type="nucleotide sequence ID" value="XM_012914392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEP9"/>
    <dbReference type="GeneID" id="24566201"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401520"/>
    <dbReference type="OMA" id="RHNEHIL"/>
    <dbReference type="OrthoDB" id="364124at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="203" mass="22917" checksum="AF88FDC16371E85A" modified="2014-09-03" version="1">MLNELECVWTALFGECVTPGLRHNEHILNSSIASELAPADNDGIPSRNEDAKLYSLKRVLQVALDNADPELTDVAVEAVFKAREELVNVFKDVAQDQGFHETLRDAIKLITIDALNRKVKERNPDPAPSMTDVGNVKAVRGYFEKATEIKQLLKNIKALDSDIARVQRDIQQVTDLPGYLINIQDRATLERVEEYMNAFRDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEW5</accession>
    <name>A0A061DEW5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770176.1">
        <property type="nucleotide sequence ID" value="XM_012914722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEW5"/>
    <dbReference type="GeneID" id="24566531"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404760"/>
    <dbReference type="OMA" id="VECTPFS"/>
    <dbReference type="OrthoDB" id="365025at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="49505" checksum="3CC298208B6ACD71" modified="2014-09-03" version="1">MEGSMAAVDMPSGETLVEKKSGSSSPKEDISPGMLTYSMVSCIIQGFCVLLAVHSSFMLGGMASDALKVSNIAGTVVYLLEGASCLFNIIVFWSNAVRPWLTVVVSFMQAVGSIAQIVVLQTMTGESGKYAYLAVVGFIGLVFGCNGIASFAVAAFGPVNNLGPFTFGYALGGVLPFVFSTILRTTYYTGHDADSVKGLMSWMLGFLALMSAVSATNMMIYLTREPIRKHYEQIKLDGISTVKCTFRSAIKGLRHAWKIVLIECISYITLLSFYPGIIPSAMKMDVGRRVMLIGVFQISETFGRGVAVFVDNKWLPCNTLNRIIALVISNLGTAGFLVMCTIYHDNVFMGNIVVITIGVITFGAVGGYCNSFSDKSIEGELPPQLEQEVVVSTTTVFRIIVSFLCAIGGFLSTVIVTAFPDHNAAAAAAAAAAAKAGEMGAQAAQTLGEAGAGLGDAAAQAAAAAKAGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZP2</accession>
    <name>A0A061CZP2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exportin-1/Importin-beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0104000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766277.1">
        <property type="nucleotide sequence ID" value="XM_012910823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZP2"/>
    <dbReference type="STRING" id="5866.A0A061CZP2"/>
    <dbReference type="GeneID" id="24562632"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104000"/>
    <dbReference type="OMA" id="WALSMEM"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="5">
        <location>
            <begin position="92"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="998" mass="112804" checksum="72CBA630E1C6AD19" modified="2014-09-03" version="1">MIVLEHISTLLCSADAEARRRANEYLVKWQQSVEAWQEAHALIAGNYPVEAKLIGAQTLRTKLMYDFYQLPAESVEQLCEILMSYLADPNLPRNISTTLCLAVCDLATQAAEVWASPLEYFIACYSRGALPVRTLLLLIQFLAEEAANTRVVVPPDVRNRVKQNLKRDYSNLLEFLVNLRASGNDVEITSAIFRCWHSWRRLDNFAANGQACNMFINDCLLVVSRPNARGEHGIDDETYEAAMDCMIDCLYEVADLTQQIKEKAEASSTDVEYFKQAKNDLQHVVRAAFDLCVTDEFNGFLVEAFRTNDRMMLGCFSNLVIALIYALDLKLIDEHPQVSRLLNLVTRFIELPYCIVFPRLSTDDEPNTINCFSKHYNRLAVRIQALQLLANCDPAEFCSIDEEVVAYTKRSVSVLLSVLQGESPNCQTARDVGKQLLEIVIFVATRPGCVGKADNVEYENYVAEVYDVIPYLTRLLQTDEVFETVKEHTVDNGNFAASHYGLESCFRALGATISALDMKSASQKNVAAIASVIEGVDKLLHDRMPTELREWYCWEAAIRFLKNARRVIMLDKTEVLAQKVTGLLCGAYLVALGSNTPLAAQIEESVVSSLSEVCSHLRLGRLRNWEPILQNLGLCIQRAEQEQTFALMLIEGTGNAISDLPPETVAVIIQQLSHAWFQQLEAVARNEVTLDAVEVSKLTTKISTLLRSIRMKNILHALIKEKIVPLMCLLLEKYHQQPNTVECICRCLKHAAKSIGREFAPFVHQVVQTVGKVANECIWSTYLYVVEWLYSVLPPNQPEQEEVKQLYSALTKITLGVLAKKDVPDEMREDPEQLIEDFFGLQTRFVKNSPECFDSEAVFREIAATSIACFNMRQPHWIFEFWITLVETEVLLKKFDKVAMDYLPKCVEQSFQLLGSGCRASVEHCVEDFIESLVRLIGNDVAGWLQMGLEKLPTAVLPNPRQKNIMLQALLSKTSHKAVYELHKLCCQVVMRNRTNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0B2</accession>
    <name>A0A061D0B2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LSM domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766452.1">
        <property type="nucleotide sequence ID" value="XM_012910998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0B2"/>
    <dbReference type="STRING" id="5866.A0A061D0B2"/>
    <dbReference type="GeneID" id="24562807"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105750"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="167" mass="19448" checksum="2359879B781B0A78" modified="2014-09-03" version="1">MDDDVATARSDQHSKQQWIWVVEDELGSLIWVTLRDETYYVGIFKSFDQYGNLVLTDAVRKVIVHSQRVFSDVYCGNLIIRGESIAYFCGLDATSYLNTFKYNSTFDHSRLLQVARKRNMRMMPQPMMPKLKYVELDEALALLKEEQEQFPTKKHIFSDMLGNDAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0M0</accession>
    <name>A0A061D0M0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0106500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766527.1">
        <property type="nucleotide sequence ID" value="XM_012911073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0M0"/>
    <dbReference type="STRING" id="5866.A0A061D0M0"/>
    <dbReference type="GeneID" id="24562882"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106500"/>
    <dbReference type="OMA" id="ASWKQYL"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="418" mass="47626" checksum="9A317883CA1D7BE7" modified="2014-09-03" version="1">MHTRGRQERYRIPSDQLVNFSRYVVRHEVPARSECVPPAPSFRPAQRNLRCYIADVGLPPEELPISRPNLTVDWSMVDLVDLMVDEDNPVTCPICLDESLIAPRVARCGHAFCWLCILKYLNFNKTSDKKPCPLCQHSLNRVDLKPVRFQVKQKPTVLTFALLTQEENACTAVLHPDICEMLGGTRELRPVNQIASSDSLDIQFWDVAYTDQMKLRELLKNDYLALENLALNTHDGDGATHDAVVEALSHLNNHGISVGNNDAPSFTYDADNVKEAVSHIRNVADSYVYAACDDSDPNLDSDGRTKHYCFYQSVDGCKVLLHPMLLKCLWHCCGQRVNRLPLFLSNLPVLGLEEVVVTGMMRRRYNWLNHFRMGCKVYLAHVPLESYVPPSTLHEFMRQRQIAMDMKMSKRLQSQDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D100</accession>
    <name>A0A061D100_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAP-1 related antigen (RRA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766682.1">
        <property type="nucleotide sequence ID" value="XM_012911228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D100"/>
    <dbReference type="GeneID" id="24563037"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107940"/>
    <dbReference type="OMA" id="MWHEWEL"/>
    <dbReference type="OrthoDB" id="364719at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004318">
        <property type="entry name" value="RAP-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03085">
        <property type="entry name" value="RAP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595334" evidence="1">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="353" mass="40755" checksum="9C72A9FD93EC8613" modified="2014-09-03" version="1">MKVQRSLALCLSALFIGAVSVVKQSAAVRNAVRTQIPLTALFSKVMHKINPGVGNVDHEQIIKERLVEIAMAEDAVEERVCERFADKDACQESVQRYLARCRDGKCMKLDQELHPLQDAEPTIHLPNTYQLEAAFRLFALLVADYRAENGVERIKVKSKMKSNLYRIFMKTLVHYNSSFKRLNATDTFLSRYLSTATLYYKTYTTLEPLRTALQNFSSIARYLCGKRIRMTLEEIVRHTANGAVKKTSAKYVVLKTADFSDYMEQQTNGYEYFSHHYANMTMDTLLKTMSDIVIESQKPWYVRMMRWSMQRVAIKLAKNPMSGGLLTDMWHEWELFKVRSKAHRFENFVGPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D197</accession>
    <name>A0A061D197_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0102060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766063.1">
        <property type="nucleotide sequence ID" value="XM_012910609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D197"/>
    <dbReference type="STRING" id="5866.A0A061D197"/>
    <dbReference type="GeneID" id="24562418"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102060"/>
    <dbReference type="OMA" id="FKSQYWR"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="201" mass="23186" checksum="BCC656ADE0693E18" modified="2014-09-03" version="1">MDSLVGSIPCMTRLYITTSLCLMVLCSLDIISPLNLYMSWTLILQGEVWRLLTCFIYFGSFGMNFFWNIYVLIHYCSSLESVSMHNRPADFFWMLICSAVMLLGLSQIFHHNMFYGGTMINVLTYIWGRKNPYSRVGVVFISVPAPYLPWIMMLLSYFAGYLLTENLIGIAVGHTYYFFSDVFPRMPISRGIEIFGAPRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1A8</accession>
    <name>A0A061D1A8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766604.1">
        <property type="nucleotide sequence ID" value="XM_012911150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1A8"/>
    <dbReference type="GeneID" id="24562959"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107270"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="73" mass="8508" checksum="7530180042A6A7E2" modified="2014-09-03" version="1">MDAGGGMIFMLVISSFWIVFLLIFCVSVMIVYRIWPLQNVRDIFSFFLDSHVERGMSIHDFSITQFIAKSNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1W0</accession>
    <name>A0A061D1W0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766809.1">
        <property type="nucleotide sequence ID" value="XM_012911355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1W0"/>
    <dbReference type="GeneID" id="24563164"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109210"/>
    <dbReference type="OMA" id="ITHTAFC"/>
    <dbReference type="OrthoDB" id="361856at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="314" mass="35899" checksum="02CE1A9CFB90E6DF" modified="2014-09-03" version="1">MQSACARYSLYQKYFNKCLREWYHQKSNGSGFYYANPPGILFTPLRSVRSSKRQEGTFSVPMSHWFFDKRATDQNVSRNVDVFRTPSSADSREAGMNYLHMGYDVSYTLSLGKLVHKHMDITHTAFCNHYDIAFNTLYNVGRSLDLSPEAFTEFPNFRLVTGNIFGIHSILTEPCFRTVIMSVRRKNMKEMLHYRTLTSVANAVTKGGCIILIARDTEGMNGIQKRFDSPQISQLFVQREGLSMPAIIQGDENGPHGFGHESDYPFLDSEVHDHIKTIIACEANSISQPLYVYIYHKYSSKLPNQRLSKPVNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2S6</accession>
    <name>A0A061D2S6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766563.1">
        <property type="nucleotide sequence ID" value="XM_012911109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2S6"/>
    <dbReference type="GeneID" id="24562918"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106860"/>
    <dbReference type="OMA" id="QLINKVH"/>
    <dbReference type="OrthoDB" id="364546at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010405">
        <property type="entry name" value="COBRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503:SF3">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="858" mass="95928" checksum="6F0F0460CECD97DA" modified="2014-09-03" version="1">MVCPSGWSVEFSLERDGASSSEYSALNSPKKSLNTDDAAISVVPGLHCGPAGRQTLIKWIEDNYKLRKKTQYSNPGALACRLWQESQGFSDPVAKAIVDLLKLNGVPANVTYKEVFEKHLSKLLSTLIKKSADNEERLTALAEKMVAMFQVTEIQPMLCDVLDKLDDIPQFARAKLLANTSSANNFFKIVPIGVKRKLLAASPAKLYATVAPLIEDALFLLDLGIKEEDMKGNVLYKGFHEEYKSIIAEIVNLIGPPKTHTSRVIYFLVQQTIRVMFTRSVLATKSAATRAEKKKDIEYGVWFGDQPFDASNLSRGQAQNDDSFNAYRRHAENSIGILYNLEENADETVKSVSEMRYSGSGCWNLSAIRHSITTLYQETYLLQPEEMQAMEPFISLTHIITCIGDSNVSKLPMEMLQKLAKPSKESKPHPLKIRDDMELFDVAFMLSNPIVASGILSHVLHYVDNTSAVLLSAQTDIHDWLSLLALGLSAHHIAATKFLMEVDLQLSGRNADSASPTFAGESCVSTALLRAAKSTGKPVSVAKLISYVYPVDRTVRVSEDVPPILSNVMSVKNAQRDSDPAKTAGADEDEMAFHELLVLYLPRVNIERLRAFIADCAAFCRATETYAEEEAYAREATIRIRSILESFDESVCDPKDHLQRAAAIVEKRAASTEPNRKPSVLERLHSKFKFINRTVMCILATTANVTNLFMKMMAVRIIASCVQQKVSRPVVKPVLYEKIKRINLIRLRAPTDYIWLCLIRIGFCAMNLLEFDSLTEFIANVTNQGQLCAFLPLYTLAARRGESKAIHRHIDSIHRYAPPEGSHGRFRVGQQLFRGQENSRKMARYTCACKQIEEMYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2U9</accession>
    <name>A0A061D2U9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767119.1">
        <property type="nucleotide sequence ID" value="XM_012911665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2U9"/>
    <dbReference type="GeneID" id="24563474"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200900"/>
    <dbReference type="OMA" id="FTLDCKA"/>
    <dbReference type="OrthoDB" id="365941at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="618" mass="69703" checksum="6ADC4D503528B41D" modified="2014-09-03" version="1">MGTDQSSDVAGGVSLLEECMAQYESIPCPELPLHKIQAVAGGIEESSAPVDTAVVTAFLEKALSFILEDSIELQCSTREHYEIAIARCVFRRLIFSVLFTLLNRMPRGDRKEAENELFGRHAPLMEAATHKLFANIDFEEKISLVELLWRGVRRAGNAKATKAMSTRPCVAFRGIKLLHANNFEREAISWLEKTGCLNEDFGLYKLNGRLELKLPHKIIFEHDFTEVIVTPALLRVHILIPEDQTCLKLEVPFCHMISINCDGGGLEFSFKMVHSRFNTAGLWSVPLQESVSQLVDSDDIFVTKLNLVDPVSPRLSAAIMSVGNVINVTEEEEEEPFAAQQFEQDDGPVVFQIGSESEEEDELCVQENVPILPSSLTYKVSGRRKVDSRHHFHDTDSIDDYKFMDKLSKRMDYPSSPSTLSYNQASVSLSTEVSNNMSSCEKPFGDPLLEPNHRPMHLHGHSTDEPLMLSLEHYREVKAKELLSIFKRIYREESDQAKAEIAKLCAAQETQRREAQESYRKEVVSLVKEIELNHHDLMDQLKKLLGDFDALRNNSLGKDGRKPDKARGLDMGNSLIASSNGLVEKTETAIKDIDDVIQRIRMHYVKRKIDCSRALEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2V1</accession>
    <name>A0A061D2V1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">t-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0202580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767287.1">
        <property type="nucleotide sequence ID" value="XM_012911833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2V1"/>
    <dbReference type="STRING" id="5866.A0A061D2V1"/>
    <dbReference type="GeneID" id="24563642"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202580"/>
    <dbReference type="OMA" id="NRKMCII"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="313" mass="35619" checksum="4C71AB55354131B3" modified="2014-09-03" version="1">MIKDTVAHQNLTFSFRSLRTKERQKAHRFEIGNLDTPLLESNNVQSGMGFEMFLTCKADAPPEHTQQAGNVGVTIDLPPSWLELVQDCTFTLKNTSDRIKDLERAQNKSLLTVFDRMGKGDHGQIAAISTDIANMMKKIERNMEIIGTEGNYYVENQLRKNARHKIAGELLTLSVTFRKLQKTYYDSVQEDTQFRANSGIPDVALSNDGFVQEQLQVSHEHIADRTNRLHDIAMTMQELKDMYTQLATMVVEQGSMLDQIDYNVRTFTENTKGVVRELRKTLKRETSGLAIRAVRNLIVVIFVELIIIVIKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2W6</accession>
    <name>A0A061D2W6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767302.1">
        <property type="nucleotide sequence ID" value="XM_012911848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2W6"/>
    <dbReference type="GeneID" id="24563657"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202730"/>
    <dbReference type="OMA" id="WNRTVYS"/>
    <dbReference type="OrthoDB" id="360830at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599980" evidence="1">
        <location>
            <begin position="22"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="340" mass="37512" checksum="6EACCA712BE03FF1" modified="2014-09-03" version="1">MRITCTWKLLVYALALHAADCAGILRRTVAPTLPLRPNVVPLSRGAIALAVTRELALSGPCVSENKSRAKHRKIAAQNPDLDAAIAFYAKQHDRILRELLLPALKDLSTKGTEIPRGQPKRKEFEWDIAVSTEAAPLQCAILADVPPGTVLVRPRTDRDDTTPCEYVAVEALNGLLRLQPSNLNRLFPGATMSDVEKLYAHASLATTLLAYLSYNWKLRRVVTALLVAGAAAAVRHVVIDIVLALLRSKLMWQPHVYGLWSRLYHTPAPLMLLTAKRAAELALEAFVAVEEYVHQRGVELESYMLNADLHNAVLRPAVVRDHRGGTRRYETLFNAGAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D312</accession>
    <name>A0A061D312_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766673.1">
        <property type="nucleotide sequence ID" value="XM_012911219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D312"/>
    <dbReference type="GeneID" id="24563028"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107850"/>
    <dbReference type="OMA" id="CHIHVET"/>
    <dbReference type="OrthoDB" id="365735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595919" evidence="2">
        <location>
            <begin position="18"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="381" mass="44110" checksum="F8C78C33328EBB76" modified="2014-09-03" version="1">MLGKLLSLTCTWSLIAAAQDVKWYSKKLAEEVYREVNDRFTDAHPWHRVIQVDEWSYRHWILPRNPHFDSVVLLIDSSKAVQREILDVVRLVAHRFDNASTDKGFEGEANSDTPTYFFYADVSTPGCDWIVSLHQLKHIPELLFFRAGEIGQTNGMHGVTSFNEWISKNAVTQWKFTETEFFKLLYSFCEVNAKSPCHIHVETSNRRHLVRDLISLIKSRLWLIPIILVVIPVFIYTMLYRHCWLLRLGAVSLYALNVTCLISAIANYTPLTIIPSEGFWLYTSGLLQRFYVELSKWHYVNENVIVSLMFCILSATLLALRQCAFWDCGMFPVLFISLGFIVTGWYTISLLRQKGVSFCVDWLAELSIPRGSIDVDRNFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D340</accession>
    <name>A0A061D340_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767362.1">
        <property type="nucleotide sequence ID" value="XM_012911908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D340"/>
    <dbReference type="GeneID" id="24563717"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203330"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599988" evidence="3">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="27070" checksum="F9B09EDBC1CA3833" modified="2014-09-03" version="1">MKVNTFSILSLILLRCTRIASAHCGNLGSTAVDNAHDACVVNGDVDGSPLITPKENANESSNTISRVPVVEAVGWNADILGGFLGGCLTTFFVTIGDAIVDAVTGCVRKKKLKLQKEERKEKELEMKAKEKAKQEKEKAREEAKLVKEKAVEVVKEKAVGVSKEKAVGVSKEKAKEGQQKAKEKPKDETKTEDDSTEMGKAKPKKEVKDPAKDVRKVEKERVKPKKIVKKPSEEPKPSAEIVSLDLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D388</accession>
    <name>A0A061D388_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Variant erythrocyte surface antigen-1, beta subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767254.1">
        <property type="nucleotide sequence ID" value="XM_012911800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D388"/>
    <dbReference type="GeneID" id="24563609"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202250"/>
    <dbReference type="OrthoDB" id="366608at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35616" checksum="881D3EA86CFE0D75" modified="2014-09-03" version="1">MVFHSLTDAPRDFREGIDWLVALKGTDAASNLKAISDAVYNFLVDKPAGSSKVPIYNYVTLITKGFLEQEELKDRRVVGPMLWTFNKPKDPNSDFSKKFVKTVPENGGSKIDRNGGITGENITEKLSKSVDGCETFLKSIQVPGQYKSAYSSKATWEASCSDNPQECAAVFVGIAPMLYAGLTSLWDATDADAFRLTPDRAKADLENLLNALRYVGPECRASMGPSDVANALRGVEYNVLGTLGELSDFWTFHGLDSAGVSEAEKYYRSKYVSYPITGGDNGVNMGLVNAWNSKLAKKPAKTDNALGSDNIYYPGMPTVANLNAASPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3C6</accession>
    <name>A0A061D3C6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767422.1">
        <property type="nucleotide sequence ID" value="XM_012911968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3C6"/>
    <dbReference type="GeneID" id="24563777"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203940"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="84" mass="9459" checksum="848C252EF99AE5D4" modified="2014-09-03" version="1">MGQQRIQVLRDLVSRSLPFNRSRLPRFARTDSTPLAVIVAMTYAARLSMGGRQTMSESSSLYESKQDVHHMDGVTRMCASLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3G6</accession>
    <name>A0A061D3G6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ClpB, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0204240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767452.1">
        <property type="nucleotide sequence ID" value="XM_012911998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3G6"/>
    <dbReference type="STRING" id="5866.A0A061D3G6"/>
    <dbReference type="GeneID" id="24563807"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204240"/>
    <dbReference type="OMA" id="IDLHYTK"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="135"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="588"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1016" mass="113666" checksum="141C9E957DE77DE6" modified="2014-09-03" version="1">MLRIRAVEAFRHGNHGDRNSFLGPFGSHGDRKSSHEDSGYVSHAFDNDFRLGMLPAGGTGWNAENNIDISSRVTSALLHGLANLLGFPHKRPPTALGMLATGSPDHGSPYNAGADSKHDMALHMIGHGNGHTLDSEDFTDKAWEAVSSLGDVANRYKSSFVEADMLLLNLLNLGEESTCHKILQHAGVDVSKMREDLEVHLSKQPRMSAGFGDQKVLGRTLQNVLTVTRRFKSEYNDHFISVEHLLLALACEDTKFTKPWLARQKVTYEKLKKAVEAVRGKRKVTSKNPEMYSKDLTLMAKNGKLDPVIGRDNEIRRTVEILSRRTKNNPILLGDPGVGKTAIAEGLANRIVSGDVPDSLKNTRVISIDLASIVAGTQYRGEFEERLKAILKEVQESQGEIIMFIDEIHSLVGAGDGQGALDAGNILKPMLARGELRCIGATTLQEYKRIEKDKALERRFQPVYVDQPSVEETISILRGLRERYEVHHGVRILDSALVEAAQLSDRYITDRFLPDKAIDLVDEAAARLKIQLSSKPIQLDAIERKLLQLEMERISISNDGGRDQSQSNAVGILPDSARQKSIPENRRIERIQKAVEKLQAEKEALTNAWLQEKGLVDAIRNIKERQDVVKVEIEKAEREFDLNRAAELRFETLPDLDKQLVQAVEAYEAHAKNVLSTGGQLMLRDEVSREDVASVVSRWTGIPVERLVRSQREKMLHLATELRKRVKGQDEAIDIVTKAIQRSRVGMSDPKRPIASFMFLGPTGVGKTELCKAVAEQLFDTDESIIRFDMSEYMEKHTVSKLLGAPPGYVGYEKGGLLTDAVRRRPYSVVLFDEIEKAHPDVFNIMLQLLDDGRLTDATGRKVNFTNCLIIFTSNLGSQNILELAKTPDKKAEIKNKVMQAVRQTFSPEFLNRMDEFVVFNALSKEELKSIVDIELGKLADRLAEKNIKLAVDNEAILHIAELGYDPAYGARPIRRTIQRELESRIAKDLLDDTCRENDVVRVKYDGGLKIEVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3H5</accession>
    <name>A0A061D3H5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767324.1">
        <property type="nucleotide sequence ID" value="XM_012911870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3H5"/>
    <dbReference type="GeneID" id="24563679"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202950"/>
    <dbReference type="OrthoDB" id="366735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="146" mass="15912" checksum="6BD6269485FEB7BF" modified="2014-09-03" version="1">MVGERDLIGSCDSNFKTHPFDPCNLCRKSRIRMGFKKRDLPKTSQLGSVISSILTFCCGGSDPLLTLASYLNCLTGRTPRTTGELVSFFHDFGIELHGYALKSLSPLCISLSASHPNSPEWDRLDGTGLDTVASVVPSLSTQRMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3M0</accession>
    <name>A0A061D3M0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase AAA type domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0109700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766858.1">
        <property type="nucleotide sequence ID" value="XM_012911404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3M0"/>
    <dbReference type="STRING" id="5866.A0A061D3M0"/>
    <dbReference type="GeneID" id="24563213"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109700"/>
    <dbReference type="OMA" id="MESNSAM"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="210"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="481"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="733" mass="80467" checksum="0B2B5FE528E6CC5D" modified="2014-09-03" version="1">MSANIMLNRLRSLAGAQQLQWPPVSCSDHDVTFARSDGTNTHITVDFDKLLSQLQGTFPDYRRQKLGVLRKAFASILKETFGPDYANGSKADVEMEDWSQPERRNARRKSADLPDSELRSLNATMADSYRQPASGDRSGANGTTKRAKKSRKSDADEEGFESRMLFIPERNIATRLDHVGGIESIRADINDLVVRPLKFPHVYRFLGVQPTKGILLHGPPGSGKSKLAEAIAGEAGCAFFRVAATELVTGMSGESESRLRDLFEQAKRTAPSIIFIDEIDSVTPKRENSSRELEKRIVAQLGICMDSLADHFVIVIGATNRQECLDPMIRRNGRFDREISMGIPDTDARFSILRAVSMGMRLGEDVDFDEIAAMTPGFVGADLQAVTREAAACAITRIFAERGETIAPDSVDMESAFVTQQDFRAAVGRVQPSAQREGFATIPNVTWDNVGALSHLRKEMEDHIVFPITFKNLYRTFGVAVPAGILLYGPPGCGKTLLAKAVANGSKANFISVKGPELLNKYVGESERAVRLIFQRAAVSAPCVVFFDEVDSLCPVRNSESNQTTERVVNQLLTEMDGIQNRREVYVLAATNRPDIIDPAMLRPGRLERQMYVPLPDAAGRVDILQKLTAGIPVSADVNFQTLSMQTNGYSGADLACLVREAGIAAVEKYRTEFMNASAAGVSMRLVAAPSGACVTSHDFAVALSKVTPSVTQQQIDFYERFRHRQFAGQTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3R0</accession>
    <name>A0A061D3R0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0204940</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767522.1">
        <property type="nucleotide sequence ID" value="XM_012912068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3R0"/>
    <dbReference type="STRING" id="5866.A0A061D3R0"/>
    <dbReference type="GeneID" id="24563877"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204940"/>
    <dbReference type="OMA" id="KDVGMGF"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000008">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 15 17" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="16">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR95336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="156" mass="18166" checksum="70732456AA862559" modified="2014-09-03" version="1">MDRGDAQVYKAYQKQPTVSVAKLEKLGRKARYWRDVGMGFTTPKEAKEGTYIDKKCPFTGNVSIRGRIIKGMVISTKMKRTIIMRVNYLHYVKKYNRFEKRHKNIACHCSPCFEPNAGDIVTVGQCRPLSKTVRFNVLKVERNQIFGNPRKQFRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3U2</accession>
    <name>A0A061D3U2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0205390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767567.1">
        <property type="nucleotide sequence ID" value="XM_012912113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3U2"/>
    <dbReference type="STRING" id="5866.A0A061D3U2"/>
    <dbReference type="GeneID" id="24563922"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205390"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="41"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="894" mass="103304" checksum="6CBA1A6C23F39EA4" modified="2014-09-03" version="1">MSMLFSLAYKRKYVLQCVLIFFTLYCCLRRISHKPKGGIPVVRDLDPSLKYTFTKKLKGKPFDFQFFKLKVDFLSEDAGAKIISQSKTLTHLKSIQNSDRNSYLLAPCQNTDWFILSFPESISIKHVAFISYEYYASTYKIIRISTSLVYPSDKWHVLAEIETERGQSEVFDISPLCDKGDHVGCWAKYMKVELLDYHRFEYNYYCSLTSMKVYGSTAVDVLESEITNGSGVHDKRGQNPDEFNAPSEMRRQLPYIGMSEFQNTTPDAALTKNQRIFLDKRTYKKPIPMSKSRVIARITIGESLYVFMMRLAAKNCGCGRNKLLYRRMSRFMRTNRCRMHNVMTVLDGSVQCRGYRSIWCSIGWNMMYKVCLPLNHTWFEAVVYTAIRKGIIKQQLRRAFNSRIHSPLLLCVRHNTFLGMYYCYSNFSYTSFATLTSTETIVGFVPTRRRGIPLKRLYVFYPNQALKGMVPITSKVVSHVSKRNGLVRGTHFILSDESIASATVSSGICKLTLHTHAIKHACSVYYLNDSIFKSYVFYTGNIVMRVTKNLRLLTLIAYSAYGGNVLSKIVPAITKHDVASDDSTLHLFESSDAFAWNSIQNEQSGVIDSQSNTLKKSPTHKHVLLQISERVKALEILSNDLNERTHHVKRVLDTHVDQLHHLTKKLQDILCPLHNIGRWGKYFQKEQESLLRSWGMKSFQIVYSKRLSKGSIMVQGCVESDLSAIFSMCTLLLKEGNSVHSIIQDNICPIDRVIPHQTKGVCRWVVPVTRISLFMAIMKRTKLINCCRRFGCQCLNPASSYTNRVLWMPHFTKNTDARWRYGIMDKMYLWVDASLSSVFKPIYRIISVLCDLVFNIYTLFVCLLITQFFWAYRYRKIKTLVFDIRNKIRGNIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Y6</accession>
    <name>A0A061D3Y6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0204360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767464.1">
        <property type="nucleotide sequence ID" value="XM_012912010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Y6"/>
    <dbReference type="STRING" id="5866.A0A061D3Y6"/>
    <dbReference type="GeneID" id="24563819"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204360"/>
    <dbReference type="OMA" id="IFKLPHN"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="72"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="191" mass="21838" checksum="31BA723822A01E81" modified="2014-09-03" version="1">MSCIMRCNNSEQEVVIDEQTGLPVKNHDYCRRSVAIMYFVCSFTEKPSVIYKPSTIVPQNTILEIPPPKELETPITFNPTVDTFFDADTNKIVVLMELPGFSHNDITVECGLGELIISGPRPKDELYEKFGNNLDIHIRERKVGYFYRRFKLPHNALDKSVAVSYSNGILDIRVECSQFSEMRRIQIDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D414</accession>
    <name>A0A061D414_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribokinase like superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765905.1">
        <property type="nucleotide sequence ID" value="XM_012910451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D414"/>
    <dbReference type="STRING" id="5866.A0A061D414"/>
    <dbReference type="GeneID" id="24562260"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100480"/>
    <dbReference type="OMA" id="AFAFLHH"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052700">
        <property type="entry name" value="Carb_kinase_PfkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320:SF3">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600018" evidence="4">
        <location>
            <begin position="24"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="5">
        <location>
            <begin position="88"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="369" mass="41269" checksum="1AF10506542F6F9A" modified="2014-09-03" version="1">MNASYIFAAFVGIFAYAVQFAHCKRACGFEKIERGSKSILFVGHPMIDIYARADYSVVEQLNVAKGEPRLITPETFRQLGEMVNVEARNAGGSACNTARAFGYLGGKAAFFGLVGEDEEAEIFKKSLTDNNVEDLTRRIPDTFTSQLYSLVTPDKERTMYLMFGASHKLKSTDLDESIMERFDYYAVNGFMFADEEQVKFTHKMIDAALNRGKGVITLFANSFCIRRNGKYLKPIVEVSAYISGNLEEYSELYEMSDREELFRMFEKRTQGMFPQHKLVIITMGGEGAMLIYKGKRYHVPPCNVEVVDTTGAGDFFAASILYAALNGFSMKKGGKFAHALVGDIISRMGIQISEGVRAEIDELKDCLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D456</accession>
    <name>A0A061D456_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0205110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767539.1">
        <property type="nucleotide sequence ID" value="XM_012912085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D456"/>
    <dbReference type="GeneID" id="24563894"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205110"/>
    <dbReference type="OMA" id="MAWISTY"/>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="13">
        <location>
            <begin position="355"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="14">
        <location>
            <begin position="818"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR95353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1105" mass="124604" checksum="50EEBCCECF1A9739" modified="2014-09-03" version="1">MAKAAFNGFLKAADLTVTLLIVLYLIFSTINLCIKTPLSSLVAVGILAIACASAYCLVNVKRWITQVKIVFSRPSYSKCHSQNKLLGHKNAHHSFLGGISSDIPIRRSAFSFEHLSNLSQQPFPLSANDVRYFSFNSDHGRRNQCSRAPEDISFRERFFDRLAFYSYFDPDFQKHSGLCHWLRSNFILGFQCLRWIQLLVKTQVDKTIVAQRRLDCVRNHCHCCVVYSVGVGGLDEGNYNLLHWSVELVPNSYWILEGAFQLIFCLNYLIQYIFSLRGFIDLTMTSALTQTMAWISTYLNIDSVKYDSLNHFGLLFFGPLRFLKLTQAEELLNISFDHLSDVQTIIIGIATAAVSLLFSFSGMMYLLEAPRESVNFVCPFDFIFFGVATMGTVGYGDFVPITKTGRALSILLICTCISLGAVHFKRLKEAISRNVIDMGKKYGCAIQDCRCVANSFDGVLDTVIVATPLPLESYRLVYCAVKRNTGINLCIIGGSEKICAPSSVYKFIGLSMLTVVVNNMETETHEDHNVDDQMTILRSIACLNITRHLGIPVGVQLHGSDYASFLNSSDITQICYLRELKYKLIAKSVTCRGLFYLILTLFHTPTNMKRTRAYVEDLYNLFATSSLVSRFCTSLFTDEEEEEPPKQNARLSLQEVTHQLFEIITGMKFQLYKLAFPLCTHGKRKDNGLKFLELCQYLYKVKNIFLLGIVSKDRCVLNPVDYVIGQQDEVVWHGLVLAKSLRDVLHVSMIKNPILDLLPIKVSETVSAPQLGNINAILELTETLADEHKRMDRSMFNGIFKVDDWEQAMQCFAEPRGNLILVCGWLHDMHNFLKYLLSDNTSNVICLAPLDIATNDCPMSLTRFRKFVTYIDGSAMDANSLLIAGVAKATCIVVLNSEQVCSSRRNKQLSKDSQVLFVGHLIKKIFASPSEVLKPPHVILDIQHSSCLEYLDPSLVSSMEASCGRDAMNRLWQNFGEFMTSYEMASGTIFVQDMLYGLLAHSYIPSFNSVGYDTIQQILDGDTDSNVSNNICLDELPLDLSGATFENLFKRKLFLEQKVCIGILRTYTTPIVNGEQKQLIIVAPQPAFILHNDDQVYVVWPNHMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4H1</accession>
    <name>A0A061D4H1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766015.1">
        <property type="nucleotide sequence ID" value="XM_012910561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4H1"/>
    <dbReference type="STRING" id="5866.A0A061D4H1"/>
    <dbReference type="GeneID" id="24562370"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101580"/>
    <dbReference type="OMA" id="CYWLRCH"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="763" mass="79876" checksum="9CDD06386D1FB90D" modified="2014-09-03" version="1">MADSTGEDKPTHLATTVSVGKGEEGNEGIYGTYKDSTKMEHKGANVGKMGSQAAVTSDILASQEAGASGILAPQAAGIRDILASLAAGASGTLSSQEAGIRDILASLAAGIRDILASQEAVRRDILASQAAATSGTLAPQAAGASGTLSPQAAGASGTLSSQEAGIRDILASLAAGIRDILASQAAVRRDILASQAAATSGTLAPQAACRSCILASQAAVTSGTLAPQAACRSCILASQAAATSCIPAPQAACRSCILASQEAGIRDILASLAAGIRDILASQEAVRRDILASQAAATSGTLAPQAAGASGTLSSQEAGIRDILASLAAGIRDILASLAAVRRDILASQAAVRRDILASQAAATSGTLAPQAACRSCILASQAAATSGTLAPQAACRSCILASQEAVIRDILASLAAGIRDILASQEAVRRDILASQAAGACEILASQEAATSCIPAPQAAGIRDILASQEARIKAEHSRPKKLLQAAHSHPKKLLQAAHSRHKQRIKAAHSRHKQLLQAAHSRHKQRIKAAHSRHKRLLHPPNSFHKQRIKAAHSRHKQRIKAAHSRHKQLLQAAHSRHKRLLHPPNSFHKQRIKAAHSRHKQRIKAAHSRHKRLLHPSHSFHKSRAFPSQAAYEVSPFSSQEAATGDILASNEAVRGDTISPEAAGSGAGKDDSEAGYKDKCRKTLRKFRKPIKKRFRFRSEYDRNSSSTSESCGSRNMEQVIIDTAKYAEDISTFVKHIAENLDRMIHFGPPPPKAPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4I4</accession>
    <name>A0A061D4I4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767822.1">
        <property type="nucleotide sequence ID" value="XM_012912368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4I4"/>
    <dbReference type="STRING" id="5866.A0A061D4I4"/>
    <dbReference type="GeneID" id="24564177"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207900"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="78" mass="8836" checksum="76FC71470E7B6443" modified="2014-09-03" version="1">MTAAVTVTMFESKIIYLLNRLFEPYVEGIDEEALLVSNLLSGKVVLSGLTLKPSIVHYLGLPFHLTFGDYTLQCRWQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4K1</accession>
    <name>A0A061D4K1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0206610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767689.1">
        <property type="nucleotide sequence ID" value="XM_012912235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4K1"/>
    <dbReference type="STRING" id="5866.A0A061D4K1"/>
    <dbReference type="GeneID" id="24564044"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206610"/>
    <dbReference type="OMA" id="CAPVNRD"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="68"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="670" mass="75280" checksum="9A3B5F162BA3C18F" modified="2014-09-03" version="1">MPHITQVTLSIVATALAVYVTYELWKRAQPCSSDPAEQEGGDSPQEPHTTEIEPPKVESDAQGDISRVYIYYGSQTGTAERFARALALQLAEWNEAFRCNAINLEDWEDEKISQPGATAIFTVATHDDGLFPDNATDFVKWLGKRGKDGSALRGLRFCIFGLGSSEYPLFNRAAKTLQTLLNKAGAQEILSIALGDDAGDLKGDFNQWTIKLCEKLANDFNIPPPQLSVQSRGKLLKVTDSWRDKVPLELRYVSSSPADRPRQPNIANVVCKQQWQCVDHVVLDNFNMTPNGDSQTNCLRIKPDSAFSPAETVNILYANPPHVVKYFMGKLRLKDPDLDRVITFVPRYGSTETQMDFEPPFPVPCTIRDALLYYLDLTELPDEDVLEEMGTFLQTAPACQLFNKMLNSKSLIKRMREELHVTLPEFVEIFMEDALFNLGGFLQIVKKKVPKAYTISSHPKTNSIDCTVKLVTFPIHSFKSFRSSLKKTVGYKVSPAAGDFFVRQRNYEGACTHYLCSLKQGDSVKLFRRPSAFSSVEGLDARPLVMIANGAGVAPFRAFWQNGRNDLKRILFLGFRTEAHILYAEEVEQLKAMPNYTVHIALSRSKTPMYVQHILRKHMEEVVDILKNDGVVCVCGSKPMGAQVKAIIQHFTKTDIAELKADGRFIEELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5J4</accession>
    <name>A0A061D5J4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767989.1">
        <property type="nucleotide sequence ID" value="XM_012912535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5J4"/>
    <dbReference type="STRING" id="5866.A0A061D5J4"/>
    <dbReference type="GeneID" id="24564344"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209560"/>
    <dbReference type="OMA" id="NTNAMGY"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="920" mass="104618" checksum="388A96032C83A5E7" modified="2014-09-03" version="1">MEEKTVFASTESPRRVIKFATPPLRPQKQPVISSMSFGLNDDFANVMGGDMPDSNMLEQVNSCDPMQSPRRINPNADRLSGFASLRTKTFDNNFKDIEGLKRKSELMHLSEKSLYSKLFTPKLEALQRLVEPGRFTSKEGRKPQEDGFGERLAQKRSRDPPREDEGHSSSLSEQQTLAEEPAPIIKPEFPLHTSRAPQRGLQILHGGEDYDLDEEILQKPLRAEGEQQAEQVVTLVSNDEVVNGVKKKRITVPKAAYKPLEVDEKSSNKIILRVVGDAGTETDHPRGDGDAEHWLDAIENHIEKLTDWVELRGNTLTDPRALFAQLEAVRPLWMPPEIFYLFCMKPVGMDPHEFLELIETHNIEECAERLHKFSVVNTNAMGYVIDAENETFKELSKLNKVHKRLANEEDIYSKILAKMMDNFNGQVEDLLQTTRQDLRLAAGDTYLQYGSIKNMTSWRMGDPIIREKGFAHDKASKDKMRTLQQMQEVFGEYSNVSSETSVDEAKYIYYMKLLQDMEDSERDELREQLARDRTQALAEYSFIEPPFKPHDCLAWRVVGVSCKSVVWKMYNTVKCAPVVYKQRLTGALDANTVAALHNGFKQAFDDIQKYQTKYAYNKQVIFATGFEVRAECIVERMEFIRDVPVSDLFEKTTQMTPTERLAHAQVIVREVTKLVRQLQGIDFVLPLKSSRLYLSPAGARISVGLPFPLLPADTRNLLKKHEKRTIATLLWGKQIDWYLPPEARNDTGFTRDPAAVAKAHVWMIGKILYEVVCDTTISRSSLDYNKIELCEDADTRDFLKLCLQENILKRPSVDDLLKHPFMKRSKLNYGMLPSTCSQLETGSLGPVDVGKVQCAVEILGDIETIVLNKINRTEKGVADYEQNENWEAVLGESSGEDLCPLGNKYAYNFPVCSRSAPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5M2</accession>
    <name>A0A061D5M2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768029.1">
        <property type="nucleotide sequence ID" value="XM_012912575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5M2"/>
    <dbReference type="GeneID" id="24564384"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209960"/>
    <dbReference type="OrthoDB" id="10348007at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="261" mass="29250" checksum="085ACAB8FB7D81F7" modified="2014-09-03" version="1">MVYTSLTEAPHNLKEAIDWLVALKGDDAEKNLGAMGAAIHKFLADKPVGFTKVPNLEEVKLITKEFLKNPALKELWPTKQVLRRFNEVIFEAPKALHRWFGDVYDSDYKNVIQTKGLTPETIAKQLSKAVDGCEKFLEDVKHPEQYESAYSSEATWEKSCSEKPEACAVVLVGIAPMLYAGLRSMKVACKVARLPQKVKIYVPSSSVGSVLLAAGYQEKQWPTAMTPLYVAKALKGVTYQVLVTFYDLAGFWAFYWFGNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6F1</accession>
    <name>A0A061D6F1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768447.1">
        <property type="nucleotide sequence ID" value="XM_012912993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6F1"/>
    <dbReference type="GeneID" id="24564802"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301650"/>
    <dbReference type="OMA" id="CAHAYQM"/>
    <dbReference type="OrthoDB" id="364758at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="408" mass="45614" checksum="81FFEB15E87B16B4" modified="2014-09-03" version="1">MSQNAITHRLVNATNIVFHLMDLQPYALVLPMNCKTAARNKRKIMQKILGNNRTVTVAESGKVSVDGDDKHSVDAAGSKVTPIGPTKTDSTASTDTSIADALRADGLDKSDNRLVHRNSNGTVYHSEDTSGNAASPREMRICSVQTRKDSISSDIGLGENTNESLTLKLDYDLPVDDANSPFFTVNRIVERLDSEDMKGCIIMLAARSGSSSGVVPLAGGIIEVYDEHERSIQAIWLNRSVAQRSDVRILLKTLVLRIFAHAYQINLPNRRYTKSNKLVSIYQSMLVTFPRECISFIEKEMLLSKHYEAYGFNEPHNDNPKVPCRCHKMAPEASELFYGISESRFNNLYTSLYEKLLFDSIGRMTPIMKMYPAGSFNQEEKIDQISKAVREIERSLREQGANKKARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6I8</accession>
    <name>A0A061D6I8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767818.1">
        <property type="nucleotide sequence ID" value="XM_012912364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6I8"/>
    <dbReference type="GeneID" id="24564173"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207860"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="73" mass="8272" checksum="8BF5BA30F184DBE9" modified="2014-09-03" version="1">MKVAKAAKVARSVKDAKKAAKKVSKKARKKKERKQKEQQEQQESAEHLTTFHHAFIILKSVDGHENVCAFNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6J0</accession>
    <name>A0A061D6J0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0300780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768359.1">
        <property type="nucleotide sequence ID" value="XM_012912905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6J0"/>
    <dbReference type="STRING" id="5866.A0A061D6J0"/>
    <dbReference type="GeneID" id="24564714"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300780"/>
    <dbReference type="OMA" id="GPQFNDE"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="312"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="458" mass="51165" checksum="BE2FE0DC78F5C8D9" modified="2014-09-03" version="1">MSNSIDLTGDAGVVKTILQEAQSDDLPENGHEVEVHYTGKLESGIEFDSSRNSTFKFVLGEGSVIKGWDVGVASMKIGEKSLFVIQPEYGYGDAGAGSTIPPKAVLHFEIELINSRPKPKDCNDMTTDERIQEAANCKALGNSHFLKGKYRAAIDMYDDALRYLSERDEWSEEAVKVSDVTKLQCHLNLANCFLKTEEYNRAEYNATAALAIEPENVKGLYRRALARTKMGSFGEALIDLTQILKRDSKNADAVNLYKIAKVKHQEQNERSKKQYQSIFKNITLYTEKSGIRNLDTMPKVYLDLAFGDERRRLVIALFEDTVPRTAKNFKQLCDENSEINYKGNKFHRLIKGFMIQGGDVTKGDGTGGMSIYGEQFDDEAFVDHHTERGLLSMANCGPNTNNSQFFITFRATPHLNGKHVVFGKVVEGEEALDLLEELETGPNDCPKVDITIEHCGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6M7</accession>
    <name>A0A061D6M7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="5">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">PEP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Plastid-encoded RNA polymerase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BBBOND_0302350</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Apicoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="5"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768517.1">
        <property type="nucleotide sequence ID" value="XM_012913063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6M7"/>
    <dbReference type="STRING" id="5866.A0A061D6M7"/>
    <dbReference type="GeneID" id="24564872"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302350"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020011">
        <property type="term" value="C:apicoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0933">Apicoplast</keyword>
    <keyword evidence="7 28" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="24">
        <location>
            <begin position="46"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="204"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="25">
        <location>
            <begin position="482"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="26">
        <location>
            <begin position="584"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="27">
        <location>
            <begin position="668"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="21">
        <location>
            <begin position="713"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="1077"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CDR96331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1169" mass="130314" checksum="436530473C85225C" modified="2014-09-03" version="1">MKAKREVTFAEVDEVRHMSVAKDAAAVGDIKDKWRILPCYMGMRGIARQHINSYNNFVQREIKEIVNAPSNKMLKSDACKKFYIEFIDIKVGEPYMSENNIKPILLTPQLCRMRDITYSAPMYADVEYYNGEGVASKRVEIGRLPVMLRSCVCALTGGERNGGNVDNFEMSSRLGECPYDPGGYFIIKGVEKVILMQEQLSKCRVIVETDVKKNICATVTSATAESKSRTAVVYKNQKLYVRHNSFTDDVPLCIILRAMGVTTDQEIAQLIGTAGARDFLPTGGDYILSLQDLYNEGINSRMDALLFVGRKVRPRQLAKGFFTSSKERTPKTNQNLIEDTHDILTRVLLSHIPMRNCRDFTGKIKSLCLMARRVLSVASGREPMDDKDHYGNKRLELAGQLISILFEDLFKAFLSQLKKQIDATLTRHYEIVSNCYGGKQIKYPDCLVSLPTDIITRGMQATISTGNWNIKRFRIERSGVSQILSRLSYISCLGMMTKTNSQFEKGRKVSKPRALQPSQFGLICPCDTPEGESCGLVKNLSLMNHVTTDGDIERLVELIYWLGVESADSLPARDAFDDERNMTVFLNGIILGVHQNGEELIRNVVALRRRGQISAFVSVFQNYEQRQVHISSDGGRLCRPLIVVENGRPLLTSKILNSLLAGEITLSKLFASGILEWIDVNEENNSLIVMRESDITPKTTHLEISPMSMLGVVAGLIPFPNHNQSPRNTYQCAMGKQSIGSIGYNQLNRCDTILHLMVYPQRPLVTTKAIQLVNFDKLPAGQNVIVAVMSYQGYEIEDAVVINKASSERGFSRCYSLRRMTVEIDKINYAIPRPGAAPAGMNAVDLTSEAPVDDVTGDNVIGVGQLVNKDDTLLKKLTQSSSGEIKVTPVKYHFNQPAYVDRVMCISTIADSVLYKIMLRQVRLPEIGDKYSSRHGQKGVVGLIESQENLPFSEHGWVPDLIMNPHGFPSRMTVGKMLELVAAKAAVLNGIFEDGTPFEADSLPSIERSLLRKGFHPAGKEILYSGITGEPLETLIFTGPMYYQKLKHMVSDKIHARAVGPRQSLTRQPTEGRSKDGGLRLGEMERDCLIAYGASGLLVERLMLSSDVFQMDVCHVCGFIGYDGWCAYCKQSGQTASVSIPYACKLLFQELQAMNIRPNVILKEGMSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6N8</accession>
    <name>A0A061D6N8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766795.1">
        <property type="nucleotide sequence ID" value="XM_012911341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6N8"/>
    <dbReference type="GeneID" id="24563150"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109070"/>
    <dbReference type="OrthoDB" id="10363899at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28931" checksum="61A07F77F89F2ACE" modified="2014-09-03" version="1">MVYNSLTDAPRNLKEAIDWLIAVKGDDSQTIMQTLGETLYRILSDKNVGLLFIPEIEKVKRLSKEFMEQQELKGRWFIKELLERFKRPMNKTVGLELKRLWVRFPSDYENIIKSRDVTPKDLADGVEEIVHDCDTFLKLIKNRELYNSAYSSEATWEASCSKNPEACALVLVGIAPMIWAGIQTLWDATQAAIEEKSKPGAEERFGSVLKALGYKEPECRAGMSGSDVRQALRVMDKDMLVTLYDISGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Z3</accession>
    <name>A0A061D6Z3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766885.1">
        <property type="nucleotide sequence ID" value="XM_012911431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Z3"/>
    <dbReference type="GeneID" id="24563240"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109970"/>
    <dbReference type="OMA" id="EVFWVPS"/>
    <dbReference type="OrthoDB" id="365596at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="677" mass="73291" checksum="E383914709F7ADBE" modified="2014-09-03" version="1">MANPCASKTARGDGRCTRSLPALEGLSYDSERRRWCVKVPPAICPSGGTFYFSTSGNDTTNVWLSALYHWGRLIVCHLRSKDAECPCGVCRSAFEKPCVSEKLSVFDFTEFFAEGVDATSVVPSARATVGSAALTGNWVNASSATCGCWNRNEALIPPDNLLNIENTRRYEDSLPPGSIFFDDSVSGSLSSAHRDTPRGVGFSGSNSCGGFNALASIGDGRLKSFPPELRVGEPTDHLSRCPLAHHHGFTHSTRSQKRSSSSGISPVPDFSTAGGAILASAKDRLSLTTMHVESSCLPRADSCHSAPVLHASCADALAASHFANRYHDLQTQCCTGACSAHLPAGRDYDNLRYLSLLAGHTRYGSLRKAPQLKTERFDLLHLHHHHPRRKNRPERTGEASAAHCRPTGGLTLDYITQLSSQAIPSRSDIYRAGGVDRGEGYTAHQDDNAGSSRVESASGCSSAVSTRRSTESKSQETADHLSDNAVREPSSSADFDCCDEYSSMTDDSLGDSTRKPRRRGRPRSNVASNISDMAESLRPWHREVFWVPSISRWRTSFTDEAGTRHTKTFTPSVFGGVKEAYDAAVKYKQAVDQICEASGMPESRRISLKRDIEMSLKRKRLPRNCTVDIFSHFENNPSSADDTTAPAQSAQDMASSNSSSSSGQQKATCPPASDAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D770</accession>
    <name>A0A061D770_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0110570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766945.1">
        <property type="nucleotide sequence ID" value="XM_012911491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D770"/>
    <dbReference type="GeneID" id="24563300"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110570"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596039" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="827"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="957" mass="108523" checksum="3799F35CA5368409" modified="2014-09-03" version="1">MAKLMRVPLAICAISLHLFEFIYAVEYDFIDSMSSLYTNAVVAFQMNMDDIGIASLTCPHQVNGTEYVWHPQSTSDHDVSLKTYVIEDGKFHSVLFSKVVVTEVPRSYAWKVSNDSQTELHIDLMDEYIHAITEERVVFICGPRDLVLSDALQGQLARLNGFRLIEEIPWTPVTSLVQEMSNIGKGLGVFFLNRRNTSLPLQGCGSRPSSLFASDNVTVDSETGTRSCVVDPVSESPIGFICEGRTEPDDCMRHLLDKMNRVVSAPTPHSYKHVYNRGKWVVARYFNGLALPRFNGECRCIDPLTGHVKARMEIRWKTEYVCDIASMIARNRLKPISGPWCSVMLHPGATFTIKLPKQTVKSAAADSEFEEDGDVDYDPSTVPLSQLPSTHEYETEFKPDMSLVVRQRQTIYDIDHYDEILIHEAFTGGAIEVDVSQVEGGEVTLKYRMDRPLALRKGYNSFLYHWTVISRNEYVLEKIRAVVNVSFAPTYRYNIIGCDRWRSGMFDPANDIGSLTIRYMRNGMPLTSEWLLDVRSGEEQAGIQCGDNEELLPNNCESTGYDLSSNQIAPFPTAVRNVTLYPVRGFQVFDMSFQNVPVSHACSCVDEHGYETSRLILKSNRREEYEYTVRREDANQRLLPYLLLPLNEVAYLHDHHASLRSIVLHNTPQRPIKLHWGTEFSMRCVLDDALYNGDDNAITLPNWLPYYVQFNHYTVETTAEGTMLVPKRKEDRIAGTKGGIEIIMLEDNNQYSYFTIKSNSGAILVSRDPDNSEYVPMIFVCGKELSESDFDQIDDVEYAADIPLTLTPLEEYTWNVVQIDVEMTDPYMQGCGITESRDTLFKPETPKLYDADRQQIGCKIDIQTAKEAAFYCPAPYVLDPPNCFDQVLVEGEVKNLSDISQSLVASHSNHFVTVRLYSSVVGPYEILRQTPPLECRCVTIKGIVLSTIQIENYYAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N7</accession>
    <name>A0A061D7N7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IHF-like DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768744.1">
        <property type="nucleotide sequence ID" value="XM_012913290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7N7"/>
    <dbReference type="STRING" id="5866.A0A061D7N7"/>
    <dbReference type="GeneID" id="24565099"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304610"/>
    <dbReference type="OrthoDB" id="365662at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="entry name" value="IHF-like DNA-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="DNA-BINDING PROTEIN HU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175:SF3">
        <property type="entry name" value="DNA-BINDING PROTEIN HU-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="IHF-like DNA-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="104" mass="11854" checksum="B9CBDE2E60BDC7AA" modified="2014-09-03" version="1">MYGTLSLTITKKQLIAEVAQTVEMTQKDVGAVIDEFVKLIGKYLGENREISIPKFGLFHNSLRGPRMMKNLQTGEMYTAKPVYVPNLRFYDTVKDEINQALKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S4</accession>
    <name>A0A061D7S4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765951.1">
        <property type="nucleotide sequence ID" value="XM_012910497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7S4"/>
    <dbReference type="STRING" id="5866.A0A061D7S4"/>
    <dbReference type="GeneID" id="24562306"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100940"/>
    <dbReference type="OMA" id="IQNKHYE"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="491" mass="55000" checksum="FDD2020508B20844" modified="2014-09-03" version="1">MDNEPMDADMSDEDIDYDEEWLYCLRANELDDAVKLLKQRLVTNIHVVDNNGNGPLHYCCANNLAEAVVFLLTECKMGYCRPNHSGNTPLQWAVQTNSADAVKQLLLHDYRVHRADYEKLERSDFFENVESVVLSDAHRLDDDTKRHYNITEYPSNYAANNWVGIVTPNSFGKSILNDAFSAKDQTILHAILEHPASAVLDKPTETSQTDLPIERVSVGGVNGVVHAFQFGGRIADNRPPVVRARELEIKQDEILNAQSAEMDHTGEVIWETDLVAAQWLTALARDGKFEGKRVLQLGSGCGLSAIAMYVSAAFYQKAPHTLVFTDVCSDTVRNLKFNVELNKLGADDRVRIHYLDWTKPDTWPRDEQGSLQTFDIVIGSDLVYDANLVEPLTNVIQATLSKAHGEVFYAFKQARDGARLIPEALTKLGFNVTTQPSPREFQSNPLESSNDKVLEAFFPDLQDDDYTLLYATRGNACTSDAAVHNDPVYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7X7</accession>
    <name>A0A061D7X7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765981.1">
        <property type="nucleotide sequence ID" value="XM_012910527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7X7"/>
    <dbReference type="GeneID" id="24562336"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101240"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28496" checksum="DD0AB68F188C8EDC" modified="2014-09-03" version="1">MVYLTLTQAPRNVKECVDWLLAVKGNDPERNLKALGTAVYDFLADKPVGKMEVAALEEVKRISKEFLEQEGLRKLPFIKTLLKKFNGPVNKKVYQRFAVFYDVEDSDYENVVRNTPLLPEKITLNIAKVVYATELFLDDVKDPHKYTSAYGSEATWEASCAEDPQACAMVFVGIAPMLYAGLLSLRSAGIAAPWRWLISSWAKSPEDVMKAVGYNEPQCRNSISGSDLLEALRRVNADVLHIIYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D820</accession>
    <name>A0A061D820_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767260.1">
        <property type="nucleotide sequence ID" value="XM_012911806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D820"/>
    <dbReference type="GeneID" id="24563615"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202310"/>
    <dbReference type="OrthoDB" id="366735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="26731" checksum="34F72EC1FE4150DF" modified="2014-09-03" version="1">MVGERDLIGNCDSDFKTHPFDPCNLCLKSRAKMTFRDKDLPITSLLGSVISSILTPSCGGSDPLLTLSAYLNCLTRLTPSTTGELVSFFHDFGIELHGYALKSLSPLGISLSAIHPNSPEWDRLDGTGLDTVCRIRGSESLNSTHDHLKSLPKQFGDNLDHLHRHPQLLPTIYHSHALYPLVFDYTIFHFLNVLPCSQLFRLPTCFTSSTSRQYSFTGRGYSYLATTSTTSMTPWANIVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D850</accession>
    <name>A0A061D850_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767285.1">
        <property type="nucleotide sequence ID" value="XM_012911831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D850"/>
    <dbReference type="GeneID" id="24563640"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202560"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7928" checksum="CF74F8070DF10EDC" modified="2014-09-03" version="1">MDGTRCSQQQTDMESAAYTSIVQRQPGKRENRYLPNMATPRAAICKHKNKVPMRVSPSVTEHNRVLLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D851</accession>
    <name>A0A061D851_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0307500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769032.1">
        <property type="nucleotide sequence ID" value="XM_012913578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D851"/>
    <dbReference type="STRING" id="5866.A0A061D851"/>
    <dbReference type="GeneID" id="24565387"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307500"/>
    <dbReference type="OMA" id="NPPEVQW"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000002">
        <property type="entry name" value="Beta-adaptin-like protein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="588"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="885" mass="97636" checksum="27EFF22B988F0EAF" modified="2014-09-03" version="1">MDGKYFRGNRRSEIQELREELQKASKDRRKDAIKKIIGAMTVGKDVSSLFPEVVNCIQTNNLELKKLVYLYVINYAKVQPELAILAVNTFCKDAKDRNPLIRALAVRTMGYIRLPAVTEYMVEPLMRCHSDPDPYVRKTAAICIAKLHGISPQLVRDEGFIDVLERMMSDTNPMVVANAVSTLVEISEQSEENLVARILAKNPAKLEGLLHSLNECMEWGQVYILDALMLYKPGSPEEARTLIEGVLPRFSHINPAVVMSAMKVVIKMLPKIGDKEYLRVLQGKLAAPLVTLASLEPEIQYVALRSILVIIEKWPRLLEGHVRAFFCKSRDPLYVRIEKLEIMVRLATTSNFQKILAELSEYATDIDHDFVRRAVRAIGSLGVRLEAALSACGNALNELLRLRAAHLTEECTIVYRDLLRAYPHMFNLDLFSMCADGEYLHAVESKSALIWIIGQYAAKIPDAAEYLANMAETMHDEDHAVQLSLLTAAVKVAVTRGRDTGMVEHVIERCVHESASPDVRTRAQMYLRLLEHGDAVAAKVVLAPLPPIGEAVMDSEVLDNLLSNLGHVSSVYHLPAWALTFKDAQPLGASREKQSGDASSSDGDLLDTADSDISPRKGRSFDGLDDYDEDQRGGRDLQPYHGEDDLFETFGRVFRYTCKDEVVLTQHQQGSNGQIGLQVVACLYREGEKMSLKLSMTNKTAASISLLAIQFNKNSFGLSPAAPLASPVLVAPEKTTEAHVPLAANVIMSNTPPANPIALQVAIKTTVDVFYFRVFYELPIVLLHGARITRSEFEELWGLSGQEETFAVGDSLPVTDRLAKAGLSFVGAGLNVGSSKANECFYASTTNSLQLLAVFSNGRASVKAEAAALVPLFVHTIGKALRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D854</accession>
    <name>A0A061D854_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768358.1">
        <property type="nucleotide sequence ID" value="XM_012912904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D854"/>
    <dbReference type="GeneID" id="24564713"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300770"/>
    <dbReference type="OMA" id="LAVFMCD"/>
    <dbReference type="OrthoDB" id="364081at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="515" mass="57488" checksum="CCE97DADD7F38008" modified="2014-09-03" version="1">MRAQQRLLLLYFGAVLTAFYSVYYYIVRGGRVSLTRYNVDDFVGKSPAPFVRRCQIFYEDSGQAAMRKMADALYRRLDAAGVSSEMLDLARYEHFGKVAGDAAIVESFNDMLDISGPFTVVLKYVAEPPFKGDFEMVVHGGKTLVFTLTSSAFGSLYTGRRIYDLTHSIVFSYEGMPSTNMTPLLDLNLVLTSDDCKIGWNVKEDVINPYFHPIANVMSLFYDISIHSRVVSGANLTGVMKLKGEHIVDLQEQDVEFFHFIERITTVEVPTRDSSIYRHSIAFVCHAPHKMLRFYDRALKRETESVMLKGLGVISLLDPAGDRSAGYELTGDDIRSLTASWVTYIRKLHNLPPSLTEMVADTMQGDEAITVVEDGHYVVESPRLTFSVRTHAPGLVAFYGFEVPKIATSLYNLYVKAAVDTLQKVVKPLSAISFMTRVSPAAANSVKVRATCRIDIEALALARTAFKQSLEAMGDDETYAKDFVSTEHGFASVMCDAFPFIFPLLANSVKYLLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D878</accession>
    <name>A0A061D878_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0202810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767310.1">
        <property type="nucleotide sequence ID" value="XM_012911856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D878"/>
    <dbReference type="STRING" id="5866.A0A061D878"/>
    <dbReference type="GeneID" id="24563665"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202810"/>
    <dbReference type="OMA" id="WIDEEYV"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000053">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="109" mass="12514" checksum="9BC573D388275A45" modified="2014-09-03" version="1">MAGSALWPEPLFFNFFQTLVEKGANVTIELKNDLQLTGRLHAVDQYLNFKLSNVTANDTERYPHLLSVVNCFVRGSVVRYVFLNSSDVKTEELQELCRREAMKQSSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D884</accession>
    <name>A0A061D884_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767315.1">
        <property type="nucleotide sequence ID" value="XM_012911861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D884"/>
    <dbReference type="GeneID" id="24563670"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202860"/>
    <dbReference type="OMA" id="SIPEAHI"/>
    <dbReference type="OrthoDB" id="10517099at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="20565" checksum="363F973F0C800B7E" modified="2014-09-03" version="1">MYTSVRSTRGVRNRESSLLSRLVCALRGSRVLVTLSNGTTIAGVVAYYQGDIRTVNVHDSVLDLQSFEGPGRDLQLPPEIRDACLNSKRAGSQLPARHKIVTSPPSHFGLTGATVCLAGRRYSVSKVEVDERWVSTVLPSDGGATDTKPGSRSINTAPQLRRLVLQQPADEIKNAAFLRCSRIGEHNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8C2</accession>
    <name>A0A061D8C2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768413.1">
        <property type="nucleotide sequence ID" value="XM_012912959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8C2"/>
    <dbReference type="GeneID" id="24564768"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301310"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="9520" checksum="1C8A3927DAAAB1BE" modified="2014-09-03" version="1">MLTIAKDLPNSAYIVAALTTMTRAKNGRNLDGIDAKHIGNMPYITIDTETAKTYKYVPTSEAFRAAINANSQMNKKKSEKATLCVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H1</accession>
    <name>A0A061D8H1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0309090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769192.1">
        <property type="nucleotide sequence ID" value="XM_012913738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H1"/>
    <dbReference type="STRING" id="5866.A0A061D8H1"/>
    <dbReference type="GeneID" id="24565547"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309090"/>
    <dbReference type="OMA" id="NMSICYS"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="8">
        <location>
            <begin position="345"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="531" mass="60031" checksum="DBB80E52FA541F05" modified="2014-09-03" version="1">MSDKSSSSSSSSPASSDIEVDEPVDVQACVAEATSLKEQGNAAFKAADYDTAAEAYQKAVDRLRKLPSDVTEHDGMKSVLYSNLSASYLGMANHEKAISAAEDALRWDPGNKKAQYRRALARFNFGYLDEAKSECQAMIAEDSGNSNARMLLAKIVERQKHLREQQKKAFGGLFNKTGGLYVDRTEEMQQRKQRRFEDFNRERREKGEDELDFEAWERKEEEEEQKREAERIEKVKAEEEKKRNEANGDDKKRNGAQAPEEPKSPTAASAAAKKPKQEESDMDEEDQKIIQETKKMGYCYFGKNKPEGNLTSSRVPQKIETDASSTDTVSRSLSSWNSKGTTYEEKDMSSWCRKAISDSLKAARYENDPSLRDPSVNVMEMLSNINIDKLEDSANLEKLEKLAMMIHKSSIRVTSVADLECDAQIALIRATRRYMFDFSCALKFEASIDTAFGSGYSSDDESKASVYRGTLLLTEISSAMEKGKTYSDYMRVSFEDEPKPEHAELMRCMMDKFKTSVCERIDAFLDAYQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J6</accession>
    <name>A0A061D8J6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0203920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767420.1">
        <property type="nucleotide sequence ID" value="XM_012911966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J6"/>
    <dbReference type="STRING" id="5866.A0A061D8J6"/>
    <dbReference type="GeneID" id="24563775"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203920"/>
    <dbReference type="OMA" id="REPNTKK"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="742" mass="81268" checksum="AE739C0981340312" modified="2014-09-03" version="1">MTGSVKDMIRSVRSCKTPAEERAVIARECADIRSALSSSSSSERRKNIAKLLLIHLLGHSTNFGQVECIKLVASNKFIDKRMGYLALSLLLTEDTDVLTLAINSIKMDLNGTNPYAAEAALTALSNIGSREMFQELFYDLERLMKSPAVNVRKKAVVCAARMLRKLGQASLIPGPEALEVATNYVHVVPTLLGDPNHGVVTAALSILSVLIDYFPQCCNFPSIYELLVKTLHLLCNESTGGFGMMFGGGREYEVNGVNDPFLKVKLLALIRRVFAKSRDQVPGNQQLYDIVVQVVKTATISNNASNSLLYECVRTIYSEVHDPKFNQLGKDVVEKFISTNDNNVKYIALGILNNLVDVSLTVGDNYWTIIVQSLRQPDISIRRRALEVALKLLSRETLKPLMQHLYDFLIASSNDLKRESITKIAAALEQHAESDFQRLEIMVKIFSIAGNCVPDTILHSFIAAVGAATADTQIRITTKLYYLLSNNLGQDALVRAALWCFGEYAHMLPELEKVDVTPTSSVRPTTDAPAEVSQPVSDNLIDVFDSSPVTEPVKVASDPLAIGEECASTAANIASAVEAVGKHVLTCSATATESCTNGEYLLTCAAWLVCRLPSQSERMVRLIRKFKRHPNTELQQRACEMDVIRELGALPVLLGIGGGKMPDTLCTPAAGAATTASELLLPREAIQPRAANDDLLGLTELPSPKTQSKNQLETLDFLSFEYNTSSEKTTKANDEFGQFDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M8</accession>
    <name>A0A061D8M8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0204220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767450.1">
        <property type="nucleotide sequence ID" value="XM_012911996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M8"/>
    <dbReference type="STRING" id="5866.A0A061D8M8"/>
    <dbReference type="GeneID" id="24563805"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204220"/>
    <dbReference type="OMA" id="IHRRCIC"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="172" mass="19171" checksum="F30269C8A2A611F4" modified="2014-09-03" version="1">MDLENINRQSGVIHRRCICLSSGHMPGLQPQLQVNLPSSFKTLNSVNQKAAGFSSQTSEVSSTLEQEVETKLRDLIRRERVLLLLKGTPEDPRCGFSAAVVNILDKYTTVDYAYVDVLSHEYLRPCAKKIADWPTFPQLFVDGRLVGGCDVIQSLHESGSLAEILIRGEREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8N3</accession>
    <name>A0A061D8N3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768483.1">
        <property type="nucleotide sequence ID" value="XM_012913029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8N3"/>
    <dbReference type="GeneID" id="24564838"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302010"/>
    <dbReference type="OrthoDB" id="10364099at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="34486" checksum="BD40D0D0A880C80A" modified="2014-09-03" version="1">MDVFVQNLFDGIDIPDDLSEVGRINTTAPKHEKNPTQDENRHMGQPAQRHQAQIQDNANACQTTKVAPVITAGLPVLAHDGGFARPTKRPIFDVKAPFIAPKPCPTPSQPAAVPTRRLVEKPENTKREETCTSTNGRKLSHAVKKTIAERFPLRGPAGIRSYRSLVDIMLYGESAKDAAGREKHAWVKALDMLDSNSKLKPFQQTNFIIHSPGMQLQEHFSVSEYVTKKYNIKWIINEASIRHVGFKMDWLVVFVLSQRTLGLQVMYAFMDKTGQMLGCMKEELHSNLKTVEPGCTLILKNVSCRGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8N4</accession>
    <name>A0A061D8N4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767455.1">
        <property type="nucleotide sequence ID" value="XM_012912001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8N4"/>
    <dbReference type="GeneID" id="24563810"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204270"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="10949" checksum="5C9B1BEB57B95BA6" modified="2014-09-03" version="1">MSHSNKADSRPTPSIMLSTISLDLNISQMLHWPPPEHLFVGKVVPFKQLESAEITALVEGVIATLRMAALVIRLHVVIISCLLIPPPNHRLAKLVDGSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Q9</accession>
    <name>A0A061D8Q9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0308270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769109.1">
        <property type="nucleotide sequence ID" value="XM_012913655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Q9"/>
    <dbReference type="STRING" id="5866.A0A061D8Q9"/>
    <dbReference type="GeneID" id="24565464"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308270"/>
    <dbReference type="OMA" id="TTLCCGE"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="385"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="53920" checksum="A1552305689BBF8E" modified="2014-09-03" version="1">MSETLQWKLKGTNSAFSTSKLVQLPCTVGVAREKLKEECGLQHVTAIDFVLYLPSSEPEVLPDSYMLGEQCQVLVARCAAAEARKLLEAAEKRFSVSRTATISNAESSSATISRMPTTVSTAQSSSATISSRPSVDSQPQESAAESVYEETDEDASLTAFGRVSSAVSRQESAGDFEDATTHSSISEPSLLNGAASSVNAESAVDSDDEDSRIQAAMQERDFFGGESTEALSRRYYRNRTLAASAAPASDGAPAGGVATARTAHSHAAYPAPGVRFDNGTIDPMPVDENYICHMCGQRGHHIKNCVQPEGKRLHKKIRPATGIPVDFLQVIGEDEIGNYDEFAVMKDMSKVSGGAFFTKSADQRIQSQLGLSETESKNMARGLRCSICNNFFNNPVAAMCCGESFCLQCVVDRAGGRAKLDLSRIYHCHRCQSELRISDLQANTALKNAVDDLVLRKNWEPRSRDAHAAVKRSATPAVVNGKDLVDVAFLKKWVIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S9</accession>
    <name>A0A061D8S9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0308520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769134.1">
        <property type="nucleotide sequence ID" value="XM_012913680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8S9"/>
    <dbReference type="STRING" id="5866.A0A061D8S9"/>
    <dbReference type="GeneID" id="24565489"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308520"/>
    <dbReference type="OMA" id="GCNINDE"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="10">
        <location>
            <begin position="499"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="677" mass="77462" checksum="E5D0ED34EEF9A3E2" modified="2014-09-03" version="1">MDKFSREEREEYQHFVNVVYAFLSYRNDGSIDAERIYRSMQMLSADDRELLIEQPGVRVMKIIHALIKNQSFINTMLSCLSGCNINDEADDYDPMAPDQSPQSSEGGDPDKERLMDNLRKVVRNAPFWQMPKEVADSEIVPTQDQEILSRNAHWVRTTLRQFVRDWSEEGAEEREQAFAPLLESLQRHVPIDNPEKPPRVLCPGCGLGRLPYEAVRLGYDSQGNEFSSFMLIGAYFATNYMTKKNCFKLYPYCLSTSNRVKHEDQMFTCHLPDVAPAEHDMKRDFSMCTGEFTDVYATVETPFDAVLTCFFLDTAKNAIEYIRTCARALRRGGLWANIGPLLYHYADFNHNSVEFSWEELRKIISTWFDFVREEWRDANYTSNKRSMMKTNYKCIYFEAIRNDVEEKKANSTEPFVFVGNVATVGAEERGSGSIPYHVAFHVKNNCAKNDRHGDIIAYVIARGGPRFHWRATAFVDSSTHQAPRHRTGPVFAQRWKYTRVTLLKDTPHVGKAGEVAIVNRNYAFNYLVPFGFARYTTRAELIGIVLDTEYKEALANVRKSSAVHMKARFGNDTVLPFETPAQSDGSNLLVSPLLPIDIIDKMREKKLLLAVDMLREQDIKILTDTGTITEFGVYKVQLNVDPEIDIQITADVKEKPLDTSFLKDVVPSESSQEPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8T3</accession>
    <name>A0A061D8T3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0104640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766341.1">
        <property type="nucleotide sequence ID" value="XM_012910887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8T3"/>
    <dbReference type="STRING" id="5866.A0A061D8T3"/>
    <dbReference type="GeneID" id="24562696"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104640"/>
    <dbReference type="OMA" id="YCKPSQL"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="159" mass="18063" checksum="31A639581D81F10D" modified="2014-09-03" version="1">MRRQVLVTVGTTCFDGLIEAVDNVETQLELKRLGYTHIYYQIGRSSRVIQQNILVTRSVRFEEDFVERLRESELVISHMGAGTIIDIFRLKKKAIFVPNNNVADNHQMQLFGVMDGRHVAALDTLRSRLSTATETPGDFFGRLLPAVPLNEVVERTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U8</accession>
    <name>A0A061D8U8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0302960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768578.1">
        <property type="nucleotide sequence ID" value="XM_012913124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8U8"/>
    <dbReference type="STRING" id="5866.A0A061D8U8"/>
    <dbReference type="GeneID" id="24564933"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302960"/>
    <dbReference type="OMA" id="FTCATIC"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="294" mass="31027" checksum="8CD0740F8633F7C9" modified="2014-09-03" version="1">MSGRPFSNPAGANDFLNFEAPSYGHFGADSNGGGKMAGKGFGSSAGMMGGDHTPSGVPPSDSASSAFGRPKEDNYLLKGIEFVKSSASNIQKGFGDSTRSNSLFGNDSGLLGNDAASTARSSLSALMNVGRSVIGLSGGNEEPQSWLNYTNYKIFLLLFITSILFFALAFMTLPFIVFAPHKFGLLFTCATICFMSSLAFLKGTGALMEHMLNSKRIVFTGALGTSLVSTFVFTTVYPIYLLAFISSLIQTLTLASVILSYIPGGAGALKLMYSSVWEFVKSRTRGSGSTTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8V6</accession>
    <name>A0A061D8V6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768588.1">
        <property type="nucleotide sequence ID" value="XM_012913134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564943"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303060"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1729" mass="195448" checksum="0A8C7CF23D9235E3" modified="2014-09-03" version="1">MAPQFKRLTDCPENLREAIDWLIQVRHGGDGKGLDELAKAMKKLIEGAIVKSFSSFCDHLCTSLDSAGKRYECCRIKIEGIKALKSETNKAGNVEDNKLQRLLNEVKALKNGCETNHRVDSSTNKALNDVQSRIEYLEGLSKNLSEFTRDPNPILKQLCCGLETFLGFDPKTKGYDGTGIVYSDLDRLCDAVMAFLHRVLESVKEDESVKTYWSCVNEDVDTMKSQLQTGQKGLGGFLSAVESGVINWERVCHEKVGKVTDELKKLKSNLSKDLKFIKKENVELTSVEGHVNRCIQKAKASITALVDTPDSGIRALDPSLQNNLKEPSRHIRREIWRFGSSAVRNAMHLQELSDKVQNELETLEHNVKYEIKERVDEYKSTLTSVFSIINKDIDRIRDKLKEHVQALTTWIQAAELLVTQAIPQIDAILNAILDRDNKTHPQNIRTSAETLQRKADALRQAVENAKAVLEPLVGSISSAVKELEDVYKQTLKALQSTLKHQITEAQGKLNQLDGKVRDDLGGQVKEHIMAEITKVITQFKEGIMTAAQDEGTSTALFIQEFRNGLNHRGDAKALWQWADAWGKSRGVGHPLEKLQRVDTNFKELKEVLKDLENYKFNTKNFFGVIIDDLESKLMEAINTIKRNLLRSMPNYHGHANNNNGTIHMAIKGVQTNIDEYFQGDESGELTEEKLEQHGYKGGEKNKRELLTDEIQKIESQGLAKFEPFENGRRDAIEENTFSTLYGNITSNLTQLISAIKENGDNDQHGKEGIKQKLETLRDTFFNKKAMESNDSIYKISKDLDELQSRILGELIKKAADFLSNTIPNKAEKCVNDIHKHLSQASENARYRIIHEAEKQYKAARIFELEVLEKSVEKQFDEITRRLAADTTSGIKGFLKMIKGEKSGNKFEALKNSSTLDVLYIKIRDYLKSINNYVASEFDNPPYLRYIVSQLPLYLENLLDGLARHDYDHTVSTNLAELNKWVAHIHPKSLVEPSNLPAEALKNGLQAFGTELGKAYFNKYSGDTWDLRCWYNFGKIGLTILHTLHRDLSGLLDRCDNEWRDMNIDLRDNSALGNSLDNCGFKVSDAIEKQNGELNKDKKGENILTLLIQNDRLFERAALYKGVVIDLSYNLKLYYKAHQLRIIESYKAPTSVFEMLCWLSGLRHSRAYSGLRDQIKSLFSKPQKDETRNISKMNPSELTLSAYPESFSAADIQATIRDVCRNSHAVLTSILGHGHARGIYACDFSNNALNLHYPTDLITLLCLFHDILRCLHHQLYFLYKQCWYDTKMSGWANCWYGKGVSGSHWQCNELQCAECGNNTNCSEHPRCDIRSPLQSFLEDGLPGFLPHPLDGKSGKIKCTVSSHVSAPCITPMGFSDISVTASHRSTGAHLKSVVGDFCGDSTACLSKLCSQLNCLLPSAPKTLGEMFAFYYNFFYDWDASGEHRKDALGEAVKDAYFGSDYDLNSVSNLVNSTDHATIKSFSKQELGHEAGDLHSLDSFDKTCYTTDKYCGSYINALTSDTCRIFSKYNAPHYLSWVIYLTESFYNLICELYKQCHANCGTEYKKCLVTGCVDICGVNESNNHKATKHGSRCNSILNCRYTMQTLYNCGLTFGNRQHLKGRYGKFSTPKKTCRTFIAQLEVVCSDSSILSKLIHRTIPEFLWKIREPFSYLVLALWLLSFLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVGKLAKLTYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D921</accession>
    <name>A0A061D921_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769382.1">
        <property type="nucleotide sequence ID" value="XM_012913928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D921"/>
    <dbReference type="STRING" id="5866.A0A061D921"/>
    <dbReference type="GeneID" id="24565737"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310990"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="173" mass="19770" checksum="B20C79ECFFCB480F" modified="2014-09-03" version="1">MSPINGWDTANLKQKKQWQRDLAHLLHNLKDTKAVVLCGYLNWYVEGIFSHIFNSAPEDIDLSDSEKLKMESSPVLHNSGHTGFPGCRPADREGYKWILLAGRLVDSFRRLHPYKGKDKNPNNKKYTSLVYLGDKTRCAVRTNLTLVSNYFMKNVSQCEIIGNTNDLVSARNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D983</accession>
    <name>A0A061D983_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNF2 family N-terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0304450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768728.1">
        <property type="nucleotide sequence ID" value="XM_012913274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D983"/>
    <dbReference type="STRING" id="5866.A0A061D983"/>
    <dbReference type="GeneID" id="24565083"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304450"/>
    <dbReference type="OMA" id="CCKAKLH"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="195"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="859"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1014" mass="112760" checksum="9890570DE8EFA53D" modified="2014-09-03" version="1">MVTTASFFLGVSRSRNSIIEDSGADDLGGYAFSGVDAADVVSARGDTRSQESPSADSAGDAASEQVPKKKKKLKRQRSDLDSDEESADKKAEAARAAAAAAAEREAKEALRKRKAIRETLETLHAFLDITKKMTETVVAGMSGGQLKIEEQIRAAIANGSCTFIRSYSDLSKFSVASKFKNLKLYQQCGVHWLSLLHSVEHANGILADEMGLGKTAQTSVFLSYIYSIDTKEVANDFNARLKKEGYGTKRSCLILVPSSVVDNWCKELRRWAPNLKNHIVKYHGPQSARFKIACDVIDDVSKGSFVILVSTMPTVSSKEDVRLLRGIREFEYMIVDEAHALKNSETIAYRRLNSSFNIRHRLLLTGTPVQNSQSELGNLLQFAMPDMFDQSRINDAINYLIKNYEDAVSEFPALSSLVEPGEIEAYKKTLPAPPPPKAPTKRGRRSKKAAADAANATEADAGAKEAAGNEEPQEKNQSQPDPTGKTNTNAAATENDAEEAVNNGETVRQVDVDAVHTPRSPQRPTEIPKDEVFKSTSFGSLLDSGLNSDANDGLKDTEMSDAKSPADYTMLRIGSMSDASAGGVDADVDRVKCEPTSVEHKDAALKAANQSDSNPSTSDASLLPVADGVKVERNPNLVMGTVDEESTDSFERFDSVQSDGEFFGPDGKTVSIEPSIRVLQRLIAPFILRRRKRTVMHELPAKNTFLIRCKMAGIQQDLYLKEVESNIEQHRNALIQKYKVPESELRNMCHGRSKNYSIGSRDDFLVKSLIFRMRRICNHPLLVRGAYYKEDLLQKLIKYYASKVEGYKENSLERVEKELRSWSDFEMHRSMQSLLHFEPRLERYLIPKEAFMTSAKVVELFKIIDKVEADKRKALVFSQFTMYLDVIEECLRLNKPEVVYLRLDGGCNTNSRTEMVDQFTNDENVRLMLVSTKAGGTGLNLTVASTVVLMDQDWNPHNDTQAEDRCHRIGQTQTVEVYKLLCEGTIEEYVMECCQRKLMLDDAFSGKAVGEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9E8</accession>
    <name>A0A061D9E8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0310760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769359.1">
        <property type="nucleotide sequence ID" value="XM_012913905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9E8"/>
    <dbReference type="STRING" id="5866.A0A061D9E8"/>
    <dbReference type="GeneID" id="24565714"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310760"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="73" mass="8819" checksum="136F4C92ED40BE36" modified="2014-09-03" version="1">MIVPIRCFTCGKVIGHLWERWLEMLKQNVSEGDALDRLDLTRYCCRRMILTHVDLIEKLLVYNIYDKRNQEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I5</accession>
    <name>A0A061D9I5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZINC FINGER PROTEIN 598 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0106890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766566.1">
        <property type="nucleotide sequence ID" value="XM_012911112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9I5"/>
    <dbReference type="STRING" id="5866.A0A061D9I5"/>
    <dbReference type="GeneID" id="24562921"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106890"/>
    <dbReference type="OMA" id="YHYPCEE"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="787"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1028" mass="116238" checksum="781E50719FE18F6D" modified="2014-09-03" version="1">MGSRRQLGPEGGPVNNNGPRGRARWPANLGSPYTLFRDNLHDSILDVYMQSGVARSQSLTREHLAAVAQQPVSEHFHSYMCCSICYENALICAVGKCTHLMCFLCMMRLKNFYDSDSNVHQCPYCKQESDVLVICANPFFAHFAVQKSLYSQEGARELTRSSVESLLRVVSGDTPLDRRMLSRDAVNIKDLFGVFLRTVDVKRDTILKAPGSKMQHLVRKAQQLSIKEREERDPFKDVYNLKQSKPRFYGDHVAAGDGKLVFEHPNIYMLFRAVSSALCWVPECKAHWHTSMPLDAPELLVKAIEKLYQNRHTSFESLNKHLKSKHGLVCCDICQGHFGLKHFICEMPLYRYEDIKAHVRFGDTDRVPPIPAHVMCSACRRMQWDNTELKRHAKSDHFYCNLCDSEGFVCEIFSDYGTLFSHFKTYHYPCEEPDCMFMVFPDDLQLQLHYMSKHPTVHRSQSSRQRKAQPPVQQAAVPVTKITASVCALPTSSLPWDGNIRIVPDAEPVVPEPTPEPEPQAEPKVVSAEFEEWLRKREYLTDPQLRTADKSTELLNAFAQTLINLKLGSTVRQFDFDTFSVNCATRVQCDLERVSALVKSSSFPPRCELWERLPSDFRSHVEEALSDFRVQYGRFVEESISGKSQESGAPNLLDLVKSSMCYLMVFVYSINFHVEYEKLLRVVKASSVEHKVSPNGLMLLNVVEDMVPIASKILVKQAFDWVVNALEGAVNNVSAMKQQPVSLSAVVKKKTKSGSEFSLEVLNPGRDLSKEIGQHKLQKRQEQLLKRMGRKPNAWGKVQEAPDKRAAAPEPEPEPAAPAPESAPEPESSKADKLQEPAVDNERYAISVEDSFKQSLNSDFYAAMVDVIRNALAVNDSKFNATSVEHRLRDTTCIKINQLLMSGTRRFTTLSEFVPMQLLESLQALEPEFYRLVKEARMVNDVEGAAKKWSYRCANALRRCRVEHLEVLDYYLTANAAAMALRSDAEFPSLGDGGSAKSTVTRRNYAQALNVRSSKNFVLLDSEFPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9J6</accession>
    <name>A0A061D9J6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769399.1">
        <property type="nucleotide sequence ID" value="XM_012913945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9J6"/>
    <dbReference type="GeneID" id="24565754"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311160"/>
    <dbReference type="OrthoDB" id="366746at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="356" mass="40087" checksum="A1D489E8A6230F81" modified="2014-09-03" version="1">MALTLTLAGRAIAQVDDKLTGASLDKNLQIYINGQTTTYDGTEPLDLPVSNFVMTLSYPYLLNKLEFLNHALDDYESPHPVKPFLMKMFRYLLNKLQEDIGESSVTFESTQICREYLQFFAGVRESFKLPPKPFKYQELEYYDALTQYQEPSKPVDKHTMDELLLMCQQFYLQCYDRLQREERENTSANHQEGSSNDAPANLGDGGNTVGSHEAITKGASSADSSALPSSSSADNKAAPLRMKRSMDARKPEPSVSSQEPGPSGVNPAPSDDDKQLQRQLSEGESGPAEHEDDKRSHNPPQNKIDEDSAADWDEYFNSLMHRLSTSSEDGEPSNEPVKRLSMWKRFRKSLRKHSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9S8</accession>
    <name>A0A061D9S8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768913.1">
        <property type="nucleotide sequence ID" value="XM_012913459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9S8"/>
    <dbReference type="GeneID" id="24565268"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306310"/>
    <dbReference type="OMA" id="WIDINVL"/>
    <dbReference type="OrthoDB" id="366316at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596125" description="OTU domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38946" checksum="4D2EC04FEFE29A45" modified="2014-09-03" version="1">MNTSLVALAFAALAASAAADRWNPSTVEEYLNAEDKGQADRDHTQTLLSHVHSIDLNSLARMFYLWRVAQPKVCQRPELLDGWYFEDRWTTLQERFNFYGLAYALKEVPGDGRCLFHTIATALRSEKVTAKMLMRFLNPEASPHIVAVIKACETENGFYNTEALKKISLANMMGIYADDPVSIANFDEKEFAEKLEAQAEMQYNTRVMDDQEIMSLFKNVNLTDINDRLKKGENALELAKEVYNKIKPQHDEIFGSWIDINVLEELFMFRLVKLQEHDASIALSLGMDHPINFIILTRYTDGCHFKPAGLVDVCGSSDKSPQLPRSVIMPGDVPLPLAIMMKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG0</accession>
    <name>A0A061DAG0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0210270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768060.1">
        <property type="nucleotide sequence ID" value="XM_012912606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG0"/>
    <dbReference type="GeneID" id="24564415"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210270"/>
    <dbReference type="OMA" id="LATHYPM"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="423" mass="46753" checksum="DBC3FE93CE786134" modified="2014-09-03" version="1">MTDERSGSESAPPTTKKVYGTLGKALYYLVSFIEGYDQQMLYMCMRAFELTLGFSQSQLSTMATILLLRFLHGFGLACIYPVQQHIVSNSDKPEDFNLIFGIMQGLNCLGRLLSAVITTLIARKVLLGYYGWRTSYFVLGYIWILFGISILFGMTRKRDSNSKSVEFRTHISQALSQPFKRATTWILILTIFIAEAPICAFSYINIYLQYLGVSETMAGVAIAVTLIGGAVISVAGGLIISNRAEKYDCSGEVGFGLVMMVVRLVESLLLFLGPQPSGKLLWYHYMELATLGGTLVTVGGVDRALLTKAIEDKYQGTASAMVRTISGIASSVVLFQISAYLSDKVFAYVPFRKSFETMDADIKERSAEALRKSMMYIILTGTLLNVFCYIALCCTYMGDRNIVDGNNKGEKRKNLPSSAPVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI5</accession>
    <name>A0A061DAI5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769749.1">
        <property type="nucleotide sequence ID" value="XM_012914295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI5"/>
    <dbReference type="GeneID" id="24566104"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400550"/>
    <dbReference type="OrthoDB" id="365679at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="112" mass="12290" checksum="D8BBFB99F941499D" modified="2014-09-03" version="1">MQIPEEEHGSVEDTLSALQRVLTTTEVEAITQVNGAFAICIAESGPVMQYLGAGYYVKRAPLSVKRMLELRVSAAKEKAPPSQKNQTAEPEHGHTTEGDTIEIIERYDSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAL1</accession>
    <name>A0A061DAL1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766941.1">
        <property type="nucleotide sequence ID" value="XM_012911487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAL1"/>
    <dbReference type="GeneID" id="24563296"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110530"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="124" mass="13048" checksum="773BA5D07094912B" modified="2014-09-03" version="1">MEKMASVKDYQVASVAVHDAKMGSHVNVIVATAEHTATASSAAAVAGPCDGYVIGRCGDKNYSECIGHVRYEASGPVLNRNKYPIDCKKSHKGGPVENETRTAIALLNAHTAANYVPKIGAEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAN0</accession>
    <name>A0A061DAN0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769228.1">
        <property type="nucleotide sequence ID" value="XM_012913774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAN0"/>
    <dbReference type="GeneID" id="24565583"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309450"/>
    <dbReference type="OMA" id="PMMMPRC"/>
    <dbReference type="OrthoDB" id="364356at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="395" mass="43628" checksum="5944AFEB2A76610D" modified="2014-09-03" version="1">MQYRAEAYPFKTAVPPSMAAGRATMPPRNGTGTVFRRQNTVSRSMEPPQNTLRSPFKPDPGSRAPMMMPRCATASMLNGASSVKRNPVMSPMQYKPHTKLMPGSGMKTAVLPQPRLRSSSLTRSAVMPDRSPSAMPRQGTGMSRRNFTPSSYVTEVYPTYHAAQRSFTPSRAPTTPMQYRSRANSSTITQPGQRMPHGNGVHIAFKGRNQMKASSAQRSQSVFKGMVDKIKEHTAALPTIDAKDAAQLVGGFVSGTLSVLAHIVGDIRGDIINGLFKPEDPTYDAAKAYYYAGNNHPTIPTGMTQRIDYIEEIDKCTQMRANKTRGGGRNTNAQRSMPPMHSYHEPRPEHVRNHYPRPTAFGHDPHMFAGMSERSLEEFLLNDSYLDSAPPSMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAN3</accession>
    <name>A0A061DAN3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0402345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769932.1">
        <property type="nucleotide sequence ID" value="XM_012914478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAN3"/>
    <dbReference type="STRING" id="5866.A0A061DAN3"/>
    <dbReference type="GeneID" id="24566287"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402345"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402345"/>
    <dbReference type="OMA" id="EDFLIMR"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="11429" checksum="EE3B897BEC7DA490" modified="2014-09-03" version="1">MNTVQSIAKRFVPLFDRVLVSKIKPDAKTKSGLLLPESSNLSSKLATVLAVGAGRLNAKGELIAPTLKKGDTVVIPEYGGMELKLDGEKYTVYREEDIIGVVNQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAS3</accession>
    <name>A0A061DAS3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769278.1">
        <property type="nucleotide sequence ID" value="XM_012913824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAS3"/>
    <dbReference type="GeneID" id="24565633"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309950"/>
    <dbReference type="OrthoDB" id="346917at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="383" mass="41560" checksum="33523DB6F9859D36" modified="2014-09-03" version="1">MLNCGVEEGARSPVFGGRDGTSTELPLPGLPVCRTIAEAPGPSAAEGAESIQLPEGALMGIIFNLEQERETYLEAVAVLHRQLLEAQEHCQQLSDSHEQIRRNLEAEVSEGWKEAEIWEARYRSVAQVAKRNGVDLADVQQPGDAKLCASREVKPTNRAISLNSEACTVVTIKDLHQASTQNITAERALGARVRPVERLVSPHGIHGRANTGVVVRATRGLESSHSILAEETHGGVKDSITTWEATSSSISTRDVGKKGAHASSCTVTLPKSRVLGHRKEFSIFRNSGGDVTTERCKPSRRNFSSNNSKRCCGPSPGGVPRCGGEDVDQQHLKFTDPATTRYHGWVYLQSPRTLSGRFDRSSMVVRNANIGSTLSLVFEATDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ6</accession>
    <name>A0A061DAZ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Sec 24 protein transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0403240</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770022.1">
        <property type="nucleotide sequence ID" value="XM_012914568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAZ6"/>
    <dbReference type="STRING" id="5866.A0A061DAZ6"/>
    <dbReference type="GeneID" id="24566377"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403240"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="14">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="15">
        <location>
            <begin position="255"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="17">
        <location>
            <begin position="493"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="16">
        <location>
            <begin position="588"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="704"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR97836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="838" mass="91604" checksum="F0E2D31E51CEEBFC" modified="2014-09-03" version="1">MSDHRGPYQPPYPGTTGISDPFGGSGPKYPVHGEDVKSSPFGTSVPPASTPPPAAPEQAQPSPVIAPPPMPPTNVKPKEDVEEEKVLKGSLPGQVFHESFKFTPPPSTSAASSFTETKTGAEIMENLKSMNTPSHFIRSSVNVLPSSATLMQKTHVPLGIVIRPMAPLSEDDPEIPLANSGSEAITRCTRCRTYINPFVTFDRARRYWTCNICGVPNEAPMRYTNLSGDDENLPPELKTGLVEHLASADYMVRPPQAPTIMFVIDVSSSAVNSGMVEVVCQTISDLIKQRALPGDSRTMVGIMTYDTSVHFYELSGSNGNPNILVVSDLEDLFLPLPGGILVNVADAEAELLNLLSLLPSTWKNTTVSGSCLGSATRAAHFAMKHVGGKICLFTGSPSYFGDFSLNANALSQSKSGTPNIQPVEKCKEYAIMVSMAQVSIEMFVCTPQSVNLSALYHLSDLTAGNIHHMPFKTHVGNSKLAEELRRVITRETGWESVMRVRVSKGWKITNWFGHCHIRGSDLMVLPNCHADQTFTLTFEHEDNVVISKVAYFQCALLHTTSRGERRIRVSTYAIPVSDNASEVLLSVDPEAAVLTAAQLALSTAMNGKLSDARTQLQTLCGRISNAMSTLTSMQDVTSKIVMYVFGLLKSQCFSEANVPADVRMYHSMRLKTLPIKELAVYCYPRMICVTDVASESGERGGSWLPPSLNLTHSRLTQESAYLLENGECMILWIGKGVSTQWLQSVFDVPSLESLNCDLAEAFMSSCKNPAAVRLATIVRELRSQRSPYMSLSVTRQGDESETKFFSCLVEDKTPGMMLTLNEFINSITLRVPFRFQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB47</accession>
    <name>A0A061DB47_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BBBOND_0402510</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769949.1">
        <property type="nucleotide sequence ID" value="XM_012914495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB47"/>
    <dbReference type="STRING" id="5866.A0A061DB47"/>
    <dbReference type="GeneID" id="24566304"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402510"/>
    <dbReference type="OMA" id="EQNCIDR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697:SF1">
        <property type="entry name" value="SERINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595639" description="Serine--tRNA ligase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="18">
        <location>
            <begin position="282"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDR97763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="544" mass="60966" checksum="52D8839B4ACBF84B" modified="2014-09-03" version="1">MHMHTICLSVLVGILPLLIEGCRGHFAASRYARRFGFLHPIGLKLRNASSTTRLDASGSDVSGDASPDCYSDSETYKTLSAYFTDQERIVDEQSFGRLKNSFVRKKADGNGFIPLCFNLDALSAVPEVFHANFLSRGEDHWQTLLSIRRSYLEKVASEEELSRLSLRRSELAKAFHIAPSSDQASLRESSLALRNETKAVELHIKELNEQLDSLIRTLPNIILEDVPKTELVVEKISIDPTPSATTVVVPHHEVIERFSDACVSRSTKISGTGFSAYSGDISRLERALFNYMLDTHHKLFGYKELSVPFVVSASALRGTGHLPRFEEDLFKLDERHQCNGDRGYLIPTGEIPLLALFGNSRVPVDNLPLWLMTYTPCFRSEIQDYGRETRGLIRNHQFGKVELVCLCDSTGSDNFHNLMLSHIEYILDSLSLPYRRVLLPANQLGSTSSKTVDFEVYFPSLRKYIEVSSCSNTLDFQSNRLNVFSTSRSRIHCINGSGVAIGRTLSAILENHQSVGANERLEITVPQVLTPYLNGDHRLLEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB57</accession>
    <name>A0A061DB57_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767151.1">
        <property type="nucleotide sequence ID" value="XM_012911697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB57"/>
    <dbReference type="STRING" id="5866.A0A061DB57"/>
    <dbReference type="GeneID" id="24563506"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201220"/>
    <dbReference type="OMA" id="IFKHHEH"/>
    <dbReference type="OrthoDB" id="371494at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="297" mass="34797" checksum="F00DA8E17AFB42D0" modified="2014-09-03" version="1">MADAVGVKTPPADAIILEPVVRERVIEVPKPEIHERIVEVPEIQYVKRVTEIPEPVIQENIVHVAKPLLQERIKHLPKPIIQEKIVEVPVIQIVEKVVEVPQYVYQEKVIEIPKVVIQERVVSVPKKVTKERIVEVPRIEYKEVINERIVEVEQEIPEIVHKDVHVTHYIDRPVEVEKIVEVPQIQHKYKDVITPQYRKVPTPVEVPIKQYRNVPVTKVIEREVPIPVEIDVIQEFTCRNVETRYHEVPVPVHVQRVIEHPLPHEAFQNTAMVPQYYQTVQNNLRKLHENWMTPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB73</accession>
    <name>A0A061DB73_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769969.1">
        <property type="nucleotide sequence ID" value="XM_012914515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB73"/>
    <dbReference type="GeneID" id="24566324"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402710"/>
    <dbReference type="OMA" id="VECNCAT"/>
    <dbReference type="OrthoDB" id="364005at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600768" description="6-Cys domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="80126" checksum="3F76D1DAFDA13F2F" modified="2014-09-03" version="1">MAFYGQLCVFLIYAAAIRLLAAPGAECQLGTCAKQPCITMAPQEMVVDVLDVSPQELCNGISIRYLDQSTYVYSIEDRRPIRSAILLLMGNQVMYVMPHARNLQVKVANSLTTSQILITYEIGGGLFERRYDEELYSSLSNVFWNRVFTPQVFCVFRKEYPAPETYSFFSQLAGVLQSLWTFGIVQTQPQVPEQQYEMPSMKIDLADPSTYGKVATTKDWCRHNNLKVMCASFDNKDHLWNGIYFYKTKIPIPRLCSKFTVCHSDAIDGAYHLVNASLVGDIWVESFYSVYGVGTNAAYLMPVIDSDVFNGFRDLPSRHEPIIPSYVGEGFTLDTEKTRGDYSPIEMREVSNGKYYRYKDPSESDDNRPAYVNKVKFHNIEYTLPEGHTFVLLALTTPMLSTNYATLVTRQGFSYSLKKWYGTKMSHLRPVEINELGLLASSFADIYPLLNRAGNGSSADRQGPSTVKGDIVCLADVVHHHKQSSSLCTPLKELTNTQLLVDRSGITILKVKPNAPSGLVVVGNSILDMAELNLGSETTIYYEHYNQTPARLAITNSESGVRAMRETVKGSGNFVAMENVIFNPPSSGQTVDVNLASSLVEMGPGLTWEHQPLQNVWVLRPQYHPEVSMGSVLYYNCRVVPPQNRGYSFIVAPSGDHPQSAAYFAPTVKNIKAAVLLKHTLIGGYPACSVEPLEHTPTPLGAANVRKENFDTLFKTASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB90</accession>
    <name>A0A061DB90_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SET domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0404490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770147.1">
        <property type="nucleotide sequence ID" value="XM_012914693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB90"/>
    <dbReference type="STRING" id="5866.A0A061DB90"/>
    <dbReference type="GeneID" id="24566502"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404490"/>
    <dbReference type="OMA" id="YCMEAVE"/>
    <dbReference type="OrthoDB" id="616263at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="YDG" evidence="13">
        <location>
            <begin position="213"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="688"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="836" mass="95781" checksum="C176702F9419789C" modified="2014-09-03" version="1">MEENQDAEGGSATTIIKQEGHADDAKSEMQIETHETQKPNEEPQMATDETQKPKGQTQDASSIMARGRIEPHVRRHSLMMFQTNAAVDVCLEVEPLRGVFYNTVTKYIEEEPVEKNEFEQDIQDRDPTRYFPTSARGFSGMLKQPLHETPPNQQIVWMIARYEAICQRLQETGNSLARIRAGNANMTRQQLMQLFINEREKLFGKVEYFPVGEPYLGMPPFTHFFKREELLYFGICQSPYDTVSVDKMRDGTEIAQAIILDGTPSLREDMGTRFILYCKFERGANEVSDYTDKNQPIFQSWIHEIPIRVVRGYNAISRYAPLWGFRYDGLYRIIGVYSDNNKQGLRVWSYVFSACNPDLEPPVFLQTDEGSESVTTTDPDLKSVFINHLHIHAKFQKSIKKKISEDLRQVDVVLNGKKLFTIGIPHLLRAGGRNYRQVPLVVNFSIIYRYIRRLCKVAKVGQQWLEGPVAEYEKAKKEGSTIWWARGGFLPMKLIIQYLEPRRSLSMEVIRGQCKEKITSKKVRLQKTLVINRELAKNMARPFFPQSDTDSIWTYIELTEPIDRTWNPYEDISAGSEVHPIPVLNEVDDDEPPMVFTYIRSNIYFSRLPNLNFDPVCAGCIPDTLDKETCQIVTVKGFCKGLMDPKGRLYCQGVNKGYLSTIQSRAACSDNCPCSNDCSNRLLEGVQVPVKLIKTPNMGWALHTMVHITIGTYIMQYVGEVVCRSEMMAREHQYDKLGRFNYCMEAVEMETLHDDWQMPCMDSMVLGNIARFLNHSCDPNVEVITVWRGDDFPCIAVYALRDIAAGEALTYCYGSQYKSIPCLCDARNCRGFIGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB93</accession>
    <name>A0A061DB93_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0402760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769974.1">
        <property type="nucleotide sequence ID" value="XM_012914520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB93"/>
    <dbReference type="STRING" id="5866.A0A061DB93"/>
    <dbReference type="GeneID" id="24566329"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402760"/>
    <dbReference type="OMA" id="NGWIPSY"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="404" mass="45606" checksum="00FCD8E4AAD59DE6" modified="2014-09-03" version="1">MARGGINFSLPKTLEAARRSLGRRSRVRSDARSGGATHQSADALLRTQYGLSEDAYREYGVREGMLAAHMANKDSFVLDEGSVYTELHKCNAHNIASIFQTKPESIFSALPEGACGDVLKDIALLPEGQALGIVNRKVAVEIISQLRQYASSKRGEIRARGMLLDGKRGTGKSYVLNHVAMWARQNGWMVIMEPSPSKYAREVGSIKRSNAGSEFAVKFLETLMTANAEKLEMIDVKPQHYGKIALDGNHVEYTKRMFNPVIRKAVEEELEIFMEEEGGSALEVEVERLKLWHSYRQQFKIPVLRDVLHAPKTLVQIAKFGIENETYANQAVYELFDQLKHQTVFPLLIIVDEYNECFPVSEYLSIKYENTKFNGWIPSYHLAMPRLFSKFDGEQYTNGNVPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBE0</accession>
    <name>A0A061DBE0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multiprotein bridging factor type 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0301240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768405.1">
        <property type="nucleotide sequence ID" value="XM_012912951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBE0"/>
    <dbReference type="STRING" id="5866.A0A061DBE0"/>
    <dbReference type="GeneID" id="24564760"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301240"/>
    <dbReference type="OMA" id="KAVPNQM"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="4">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="146" mass="16257" checksum="05B85D766200B308" modified="2014-09-03" version="1">MASHQDWTPVVWAKRESYKGAHKEAALNKARRAGEDIATEKKFLGGQNRSSKAYIPTNAAKIENETENFRIERIEFHFRQALQKARLAKGLTQQSLARLINEPEAIVKEYENGSAIPNGSILQKLSKALGTQLPSAKASKAKKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBE4</accession>
    <name>A0A061DBE4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769473.1">
        <property type="nucleotide sequence ID" value="XM_012914019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBE4"/>
    <dbReference type="STRING" id="5866.A0A061DBE4"/>
    <dbReference type="GeneID" id="24565828"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311900"/>
    <dbReference type="OMA" id="HTIFFRT"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42918" checksum="D9B1FB006EEC7BB3" modified="2014-09-03" version="1">MTDYWVSTKKHYCEVCKCWISGTTLNIKNHESSARHISSLRNKMIESHRRDVARKEQEAFEAAEIARLNSVTMDGPSIVEPVGDSGFVGSSFSTHNRLLRPPVDKEKEQMQVLDTISRVLSGAPPDEPDHNRNTTWMAFIDPEDGTLTYYNNFTGLKTKNRPRDFDGVLPTAASSLTSNWTLKFDPTKGAKYYHNLATGEIRWLEAPRPSAAPAPPPRKAESSSVPPSIPIKMEPDTSETSANKAPSQIRIKLEPMESQPPERPTPPTPAAVRIKPEPEDQSQGADAYEPSQRATENRPELPKEQYAAPPIGQWEVVKPEESVFSHSIVSLDPYINPPAAPKREPDILDVIRDATYETPLLNVDDMQLQEKQVFTKHKVICIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBI9</accession>
    <name>A0A061DBI9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">40S ribosomal subunit protein S9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0202720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767301.1">
        <property type="nucleotide sequence ID" value="XM_012911847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBI9"/>
    <dbReference type="STRING" id="5866.A0A061DBI9"/>
    <dbReference type="GeneID" id="24563656"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202720"/>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="184" mass="21590" checksum="A76A5A7392308749" modified="2014-09-03" version="1">MVGSYRNYSKTFRNPKRPFEKERLDQELKLIGEYGLKNKREVWRVQYVLSKIRSAARYLLTLDEKDTKRQFQGDALLRRMVRYGLMGENEQKLDFVLGLTLNKMMERRLQTKVFKLGLAKSIHHARCMIRQRHIRVGKQIVDIPSFMVRVDSEKHIDFALTSPFGGGHPGRVHRKTLRGGSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBP3</accession>
    <name>A0A061DBP3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0312700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769553.1">
        <property type="nucleotide sequence ID" value="XM_012914099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBP3"/>
    <dbReference type="STRING" id="5866.A0A061DBP3"/>
    <dbReference type="GeneID" id="24565908"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312700"/>
    <dbReference type="OMA" id="QTRITMK"/>
    <dbReference type="OrthoDB" id="431723at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="455" mass="51133" checksum="088A2B40085583EB" modified="2014-09-03" version="1">MLQLNWGAGEPAAAASSQATTTIKPRRGDITVVKGYALLGTLGVGSFGKVRLGIHCETGRRVAVKIIQKGQTVRAGVLNKLAREIRAMSGLRHPHVIHVHELIDTPTTVFIVMEYVEGGELFDYISQNSRLNEPEAVRIMRQILSAVHFCHSKMICHRDIKPENVLLDGNMDVKLGDFGLSNSMRYGTCLKTPCGSPNYASPEVICGKSYSGPEVDVWSCGIIFYVLLCGCLPFDDDEMSILFMKIKLGKYHEPPHLSESAKSLLRRMIDVNPVSRITMKEILMHPWFVGCTIDGSGPNAATYISGFSSPALTFYRNYRTDSGENEPILLEKPEDDDLEPASAVTLKCSRFKPRWYIGLPGFKSESQCVTVLTETLKELDYQWRFEPGYKVFCKRENSPQHKLQPQFAMQLYKMKYMSYLLDIQMKTGELMPIMNEGIRLVEALKRKLNMSTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT9</accession>
    <name>A0A061DBT9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0302430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768525.1">
        <property type="nucleotide sequence ID" value="XM_012913071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT9"/>
    <dbReference type="STRING" id="5866.A0A061DBT9"/>
    <dbReference type="GeneID" id="24564880"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302430"/>
    <dbReference type="OMA" id="PQQFAIC"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="128" mass="13969" checksum="DE0D6C988D6733D6" modified="2014-09-03" version="1">MLGFLQKVFYPGVVPVLQAKVLALPLPEKAKAVLAHPAGPFTIHFYAPTFKWGISIANLADINRPTDKLSLPQQLAVSCTGIIWSRYSTVITPVNYNLLAVNAAMAVTGVYQISRICRDRLSSGKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW6</accession>
    <name>A0A061DBW6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0302830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768565.1">
        <property type="nucleotide sequence ID" value="XM_012913111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBW6"/>
    <dbReference type="STRING" id="5866.A0A061DBW6"/>
    <dbReference type="GeneID" id="24564920"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302830"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="165"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="621" mass="71042" checksum="79C0049142E74017" modified="2014-09-03" version="1">MELVLNVAEKPSVARSISEILSQGRKRTEFTNAKTNPVYSFVCPLEGRQCKMYFTSVRGHLMELDFDPKYRNWQRTPVQELFEAPVYSAVSPNCKDIEKNLLQYAKQCGTLVLWLDCDREGEAIAFEVMTVCQRVNKNIAVRRAIFSAVTRSDIEIACSRLRDPNANLAQAVEARQEIDLRIGSSMTRFMTTKYKAGISTEAKVLSYGPCQLPTLGFIVERFRKIESFVPEDFWSMQVHIERGGKVHTFLWDRVRLFDRLAVLTLYEACLENPMARVTHVNNRTTKRYPPLPLDTVEMHKDAAHYLKISSHESMHLAESLYNKGYISYPRTETNVFPSSMNLMSLIQPFTTHPQFGDYASKLVRGGNIVPRKGKKNDEAHPPIHPVKPMRREEAESHRSWQLYEYITRRFLACCSPAAVGDESTVFVDVAGEGFHSKGLVVKERHWLDIYPYSTWNGRTIPAMVQGEVMMPQKIMLTCSRTKPPGLLTETNLIDLMSKHGIGTDATMHEHIQKVQDRHYVVKEPNFTLIPTNLGKALYWAFKSYRHTEIDLTKPNLRANMESDMCLIAEGQKQKQDVVTHYAHQMKQIFLHIRHNIDGFDTAMHGLANLAPDEAPMPSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC04</accession>
    <name>A0A061DC04_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0400148</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769708.1">
        <property type="nucleotide sequence ID" value="XM_012914254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC04"/>
    <dbReference type="STRING" id="5866.A0A061DC04"/>
    <dbReference type="GeneID" id="24566063"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400148"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400148"/>
    <dbReference type="OMA" id="QTHQFRD"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="5"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="830" mass="91380" checksum="2185BFA2F12463E6" modified="2014-09-03" version="1">MSASYQPDFQLPFEAYPSQKKFMQDAYTCFEESRFGLFESPTGSGKTIAILCSLLTWLRDNRVKDAVSRLGPKVDNDEGVPAWVRRSMEAQLRSIAEEAITADMERLTATRQRLKSDFVVTDEGVRLRSGAKRGRDQVGGAHQIAILESWCTLQTGGVTTTNSASSDARPTRKKIQVVICSRTFSQLNQYVRELRRLGALAGQVKVGIAAGRNHTCVNPAVRAKCHTNEDFNDRCRQVACEYRQDVSPLVEASMCFPMDLEDLRAVGTGLCACPYYAAGQSMEECDVILAPYVSVFNPSIRQHTGIATDGNILIVDEAHNLVSAVTEAQSSVVHAKAMAALVQQCRSFTGKYMGEIGGDNETIASIEKVAGILSNCGKALSAASGSPRVFTIPSFMIEVGLEDTKFHDIVAFMASGDFCRRLRTLAERMWASKCKGVAPTDHSKRNPHLYAVYDFRHFVTTLLSASEHDRVIVTSEADDVAIEIFNLAAGMFPCYVQFQRLTQEAKSVLLMSGTLSPMEEFITLSPSSADPIVHRSPPVFPMYQFYATVVGSGTLQRLDVTLLADEQGLELVYDSSSREGSRELAALCRIVEAAASVTPNGILCFLSSYRFLKNFQVAFENSPERAGVLRHKAVFFESQGALMNASCLPGADKGSSVIADYSKQALGKGAILFAVYGGSQSEGVDFADGLARLVILVGQPYPPDDIKLRLKREYFRAKCRSPGHILILATAKQETLSRSQRDVYARLADDMKTIMCFKTINQSIGRAMRHKGDYAAVVLLDARYKSAKTQQWLPPYVTQALARDQVQSHSSNEVTSLKQKLDNFYKSQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC36</accession>
    <name>A0A061DC36_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768680.1">
        <property type="nucleotide sequence ID" value="XM_012913226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC36"/>
    <dbReference type="STRING" id="5866.A0A061DC36"/>
    <dbReference type="GeneID" id="24565035"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303980"/>
    <dbReference type="OMA" id="EWFFRTF"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="702" mass="79399" checksum="FB446F3C9368818A" modified="2014-09-03" version="1">MDTDAGDFDYYDILNVPRDSSVDDIKASYHRLIRQWHPDKNFMPVSDPSQPLSVTDRTADAYEIPQELQRDSAFTKIQLAYSVLSDPARRRVYDKYGSEGVQLKMLLQKQLDSERVESRTIPESLEDEATLQKSWELRRAADEVEIERRIHVLLQKRRWDKFRDFPVQVVSHCTFGGVTNFFDDQIATVMRRRMFQIRETCITNSVEVLLSRHTRAGYTYYSSATRGTFGKCRGGVRLSSELTDTVESTVSVEWGDYLSYRSTALSIKKMFSENFWATSIFALDRYLTPAMRCVVHKSWGEHHAVELTALPDYAMTYGYNRTFAGDLKSNLQIAASQDDLGALVRVKARSGTGSVIGTICRFSVLGGLFVEGYVRHRFDTELLARLKLECRLRYSRSSLFVIFKIVLNNNRIDLPIELYSGSVDHCIFLGTAASCLLMLLPAVAEVAMKLVSPAEPEPCYGLEGPSLRRSFYSQFPAFSYFGLCGVDARYHERYVSDSSRQGPLLSRALQWSEEGLEAIVVRELHLARQEGAALRNSAVAAYQRELESDGLCVLFAVYGHPEALRTLVEFVTMDLFENLGGITDSADSPAPRSQPIGSARRFVFGSVTVTSILKQNDQMRLQRLFDRYLLEVTNVLMSRVTDSRLQLSVNTKGQLIGFADPCANLPKVEPKLYVCYRYKKRVYAATFGDGDPVRLPDGCEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC72</accession>
    <name>A0A061DC72_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L32, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768735.1">
        <property type="nucleotide sequence ID" value="XM_012913281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC72"/>
    <dbReference type="STRING" id="5866.A0A061DC72"/>
    <dbReference type="GeneID" id="24565090"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304520"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="132" mass="15491" checksum="3859970AEF690452" modified="2014-09-03" version="1">MAIRNFRGLIHKRTKKFRRFQSDRFKRVKESWRKPKGIDCRVRRRFKGTVLTPKIGYGTDKRTRHKLPSGYYKVVVNNPAEVDVLLMHNKTHIAEIAHSVSAKKRRSIIDRAKKLGVKVTNAGARLRVEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF4</accession>
    <name>A0A061DCF4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767711.1">
        <property type="nucleotide sequence ID" value="XM_012912257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF4"/>
    <dbReference type="STRING" id="5866.A0A061DCF4"/>
    <dbReference type="GeneID" id="24564066"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206830"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="97" mass="11158" checksum="DDDE13C08A6D233A" modified="2014-09-03" version="1">MHGSLCTIRFQHGVSSPWNIGQMVLFTRLSNRSDPPTMEIVRQINETRQFIIEQIDESVALCQDSVFDFLKEEVTRRLEFAERLTPTESKPAATDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCH0</accession>
    <name>A0A061DCH0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0306080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768890.1">
        <property type="nucleotide sequence ID" value="XM_012913436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCH0"/>
    <dbReference type="GeneID" id="24565245"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306080"/>
    <dbReference type="OMA" id="KHAIWRP"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.182.10">
        <property type="entry name" value="Toxin - Anthrax Protective Antigen,domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596216" description="PA14 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="4">
        <location>
            <begin position="306"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118119" checksum="4AD1FC55141B071C" modified="2014-09-03" version="1">MRCGLLPLFLWCVALRPTHLAESAFTFYEDPASGDKEPKTSESGQPSGDTDSNGVRQAIPPTSSPDGRPSGVPKPSREATTDEGTPNDSSDQYGSYKDDGTGSNERVVQLPGSDSVSADGNQEDDSDIMYYLTQYRARPRRTVEGNLCAAAFLEKNQIYTDCTREVAPDGTQDREWCYHESQLTGKLERDWGFCVPPPNYERIRSAVIGRIREKAEQAGEMKHALTKHRALLLTMERRIMSFCGVGHKGFERSLTRLEEVLNGAEDTLKSMRSLSNDVVAIKEELKREQCRYHKIQQQLPHDASSQVSDGLVGTYFPGHLLEFPAYSTRVDRELNFVFSDFMPVVGLNPHRFSVVWRGYVRAPHSGNFVFSIETQSYVRMELDGVEIINNGLVRQGDADSGYRYSIDTMMQGATLTSQSQQLVGGQFYRVQVEFSNSQQYHYRAGEAVVKLEWSSLRLPKEVIKDYLYTKIVPQRLAISYLPHGHFVVENAANGALAFLDDEAAFLSDLSNDLVDSYLVRTVRSPRFGRFMMQVNVTCALFLAYAHDVVPLSAVTEDALQFGDSRGSFVQLVDRDGSAKPLRVKRAILQRKHTYTFHVEVRETPFFMFLSASAEEPSQGEGPVTVLSLPDSEFFLNCLQSSSVGDGFDCSAGLSGKLLDKKHAIWRPTEGAGSWLKVLFRRPVLLSAFQLKQSDDPSRWIRRLSLEFGDRSEFFEILHSNDPRSSLYHLSEPRAVSSVLLRVDDLYTSSQATSLAVNFLGQRLVEESPGLRRIFMNCTDTLESNVEVQPLSEGHSYELVCSRKCFDLTTALKATEVLDIKTPPCGALQIDLCNHGGDSSACHAALTIVRAPGSENALGFVLSRLNRGMRDVPFNVAILFKSAPNRLPQQSFLIDNGSLKGPIDASYVHQVGGNPRMGEVSYGWLRPNVSEGTSLGVAFPLPGESQRCIQTRGCQPNFWSIDLPRNGRYKVELVVGDSTVPEPSAELDAYALFSPDAAAPSSQWLSVELNGEVLLGCVEVAAGSLYTVVKEVEVRNNLLKVTSTSSNYSCAGHHTRLQFVKVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM5</accession>
    <name>A0A061DCM5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770063.1">
        <property type="nucleotide sequence ID" value="XM_012914609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM5"/>
    <dbReference type="GeneID" id="24566418"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403650"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="506" mass="55236" checksum="D67DF11C868EAABD" modified="2014-09-03" version="1">MVYNTLTEAPRNLKEGIDWLLAVKRNDGENGLLAMGAAVYNFLADKPVGKTEVPALEAVKLISKEFLEQPELRNDQLVKDILEKFIRPMNTKPSWLSKMFNHVEESDYTNVVVSRGVSPDDIAQDVTEVVNGCEHFLEKIIVLEKYSSAYSSEATWEKSCSEKPEDCAAVFVGIAPMLYAGLGYLKTSSNAGPFSFMGIKRKTNIGGVLETLGYGESNRRSWLSGPDVTEALQSVNPNMLSTLYELSGFWAFYGSGKTVIPEAEPSVEGEGEQSVIPEAEPTVDGEGEQSLIPEDEKSFEGEGEQSLIPEAEPSVEGEGEQSLIPEDEKSFEGEGEQSLIPEAEPSVEGEGEQSLIPEDEKSFEGEGEQSLIPEDEKSFEGEGEQSVIPEAEPSVEGEGEQSMIPEAEPTIEGEGEQSVIPEVEPSVEPAGEEPVIPEAEPSVEPVKPEVDDIEKPVKVAKAAKVARSVKAAKKAAKKLAKKARKRKERKLKKQQEEQAQQESAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCU5</accession>
    <name>A0A061DCU5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CDC50 domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0209230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767956.1">
        <property type="nucleotide sequence ID" value="XM_012912502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCU5"/>
    <dbReference type="STRING" id="5866.A0A061DCU5"/>
    <dbReference type="GeneID" id="24564311"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209230"/>
    <dbReference type="OMA" id="ALNMDKP"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="438" mass="48288" checksum="DF6CE773BB3C1A3D" modified="2014-09-03" version="1">MKALVVAITPKGALGFLTAGGLTLFVLGRCRRHTRAGIALILGCGNMPRCEIPYNINTNSKGVVEFNASACPKLASPLKGNYGFYYKLAGYYQNHKDYRRSIDYNQLFGNVTDRVSDLANCGTYMTDTDGKILYPCGAVARTVFTDRYELFSDKALQTAIELDESRDAICNKRGVHTLFRNPSASQVRQYHSSVSFWLQKPSMRRALNMDKPNVGEGVENSHFINWVEPASTSTVRKLYGVFKADDLKLPIYVNIDVTQRISTVVRKSVIIEKYTTLSSVGYKMGVCYVVVGVLILAMAGLSAGYTYFKKWMYPPPPPHRCCGHDHDHGAPNEEEGGSSSSSELRKGHGHDHGHDHSEGHGDDHGHGHDHGEGDDHGCGDHDDGHGHGHDHGHGEDDGHDHDGHGHGHDGHDHHDAPKPRIEEIVDEPSDDLPRHRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD11</accession>
    <name>A0A061DD11_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">-DDRGK domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0406060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770308.1">
        <property type="nucleotide sequence ID" value="XM_012914854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD11"/>
    <dbReference type="STRING" id="5866.A0A061DD11"/>
    <dbReference type="GeneID" id="24566663"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0406060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0406060"/>
    <dbReference type="OMA" id="VEHGNKV"/>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR98122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="263" mass="30744" checksum="7EC458895D752E3D" modified="2014-09-03" version="1">MDDDSGPPVSLAICGIVISLFVLIIAYIYYTGGICTSEIVGEQTEASNASLPTDTEQHSRSLTAKQLKKQELKEAKRRQRAIRDEERKERDQKKQEREDIYQQRREEKERQLHEDELKRADRAYEAYRNIVSSFVVETEGHEQQCKQFNVEDFINFVIWKKVTNLVELSAKFDLQQNEVVNRLDQLEAQGHLFGLLDERGRYIYISTTDMDTLQHYIVNSGRMHKIRNLVPFCNTALCMEPTEENASKLRAWEQSVQQYTMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD13</accession>
    <name>A0A061DD13_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0309270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769210.1">
        <property type="nucleotide sequence ID" value="XM_012913756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD13"/>
    <dbReference type="STRING" id="5866.A0A061DD13"/>
    <dbReference type="GeneID" id="24565565"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309270"/>
    <dbReference type="OMA" id="IVCIENE"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="142" mass="16958" checksum="1E1F246D23B18BAF" modified="2014-09-03" version="1">MIYGVFLQNVKNNTRLSRWYCNFSQQEKKRIADLIYTEISRRDVRWVNFYDLEGRKVVYRKYAGIVISIYTDREDNTLAYHELIHLIVEILDDFYDNVHELDVVCNFNTLHSLLNELILAGELLETSKQTVLDRMKATYKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ0</accession>
    <name>A0A061DDJ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769650.1">
        <property type="nucleotide sequence ID" value="XM_012914196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDJ0"/>
    <dbReference type="GeneID" id="24566005"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313660"/>
    <dbReference type="OrthoDB" id="10398091at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="51" mass="5692" checksum="B33C81366CD6A808" modified="2014-09-03" version="1">MMYPGMMEPAPEPPISPTVRMCMRVVGFVAVSSAIYLYGDWLDMPEAINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK2</accession>
    <name>A0A061DDK2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0314010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769685.1">
        <property type="nucleotide sequence ID" value="XM_012914231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566040"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0314010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0314010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1868"/>
            <end position="1889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1930" mass="216077" checksum="413187FB43584753" modified="2014-09-03" version="1">MLLEEPWRTLTPSSLALVTLLVNLALFESVKKAVIYAIIAQINSNEDLKNHYSSHVTKLSESVNSAVQAGDTQKISELSERVSKEIQRLEDILSKPNNLYNHSLPSPSPSADSAELHSKLEALKKVEKLCEFHGKFKSGENPSKNLLENLCSGIETFLGFNKDSKGYDGTGIVYSDLDRLCDGVMGFLSGVLGAVKNENEVTTYDKNESNNINTVIKKLQSSIGSGREGLAASVDAVKGWLEGYEREVNNKITAVVEPIEVMKNLVERDKNEIEKEKDKNLITQVKEWTERAGRYVSLADQAEKALKHIDPTLLGKLNCNISLLVQATGTFEEAARNEDLKDMYEEAGSKWNAMLQHVEEIVNARRKWLQDLLDVWIRGLYGKLFNMKSKQLYDLQKSVDDGLQWHFNTVSGGLANLLDRYKGQFVPEVEGILAAANKLKDDVLGEKKTIKKLVEYLDQRMQVLRQSDTTVKEKMRRTTLEHFKNGDGDDPWNLAQRIDGVIDVIETNVKGHVKIILEEIEGQVSRIKQHVGDKKAGHTKPEDSSIYHNWDALKDELTGFVDTLTSPGGSSLTQIVNGIRSYAEGFGSGKFVAVLKPWIGELVNDGAIYGKIFEYVLNNDRKLEGGDRPSKIRNVKSVITNNLPDFINTHIESAAVAAALDNANVSNIAEKYASFSVKLESEFEDTDGNGTIELAVKAIDKLLKTSGSSVAHTDADINLTAAVKGIVNSVINRFKQAAPELQRFVGVLKISNLTQAITQTVDIGKQFNNVEDTDIILGTPDHGYKIDVALGLVHAQIKNLHDNINNGIKQTIGAENVLPIEGDLVNKVVAIKAKVTSDQFDNKLETLLKETANKAFDKLHTKITELIDGTTAGFKHTLKEVKLEMQKLQTPITHSTDAGSSDGISDIQQQTDKLHNRINEFLTNKVGQSATMEGSVYEALATLQKDIGKLGEQVTLVRANVSAVGKELEECMKYTDEMLRVTHDETEKSFNKLRHAVDIRIRQAFKELQEKAKMLYTARKRKQVTDLQKIVNKRFDKIEEIIKFDKQLGLKGYLSKLRSKFMPPLSSFTETLSPPRSAEKKLLDFSPIVKNSFKNIFDDLQKQLDLFPTTMRVNAISNALDTLLTSLTRYDHTFTKNLAKVKSEIDDFAQQTYANTAQKVSLSLVPGLRDFVKELEKAYVRVYDGHPDRIDFDNLVKKTGQIVDLSGPARWITVSTPDGTKLAKILLTIFNFIYEDIIRLINKCEDNWENKVLCISMKNEDNPLGLFLQRCGYLVAKREDSKDGETQCRTSITGQNMLAKFNEEISNVQVKAHLTACESNLTDEGEPKKQAPFNFADLLDCLLHHIDRYNEVCHYSTHFARRQPCSVYEMLIWLSGLPYSVARPALLQDGIGNLLDNANKKALADVDGISLLDHESSYLDANPRKITWYGITEALEILCSSSYDLLVSIAGTGDAGTIYGSDLCNNSFKFKYPASGEDCLDMLLDILRRLFPPLRFLQTQCSVSASHNGWLQCTYGRDVLPANWPCKEHPTDKSKCQPNCQVNSQPSCQPKSPLMSFLSDCHVGCLPHKLTSIGCRYECKTCPTNKPGMPCLTPLGFRGFSGSMRTGKDLCNVLAKFFGNPYLASFLCLAPKAPSTLPEHFSFTLSLVTGWNNHSKYDTQTLKKSIDKSISGVSIDLYKNASELTDAVSNAYSHCTAALPKCEDSHLMDLTSSSTCNKNQYSAPYLESLCADSYLYLANKHSNAYLSWILYLPWNFHKYLESLLAAFKDIFCNDWGCRSCLNGKCKKGEHGVLDNTCQCTSMVKCSGVMPILYRYGFAFQDAPTLDARKSAMKCFDFQTILFKVTRSNYFSKLFDECDMFLWRIREPFSYLVLTLWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDM7</accession>
    <name>A0A061DDM7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769735.1">
        <property type="nucleotide sequence ID" value="XM_012914281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDM7"/>
    <dbReference type="GeneID" id="24566090"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400410"/>
    <dbReference type="OMA" id="VKACDYN"/>
    <dbReference type="OrthoDB" id="365880at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="549" mass="60666" checksum="19B3E428D7418000" modified="2014-09-03" version="1">MVRSASSKTGVRGGREESPYPGSPRTQKWIGNLLPILERYDYNYAEITQLVKACDYNGDKIQQEVDRIMEVNIGHEHGEWTVVNSQQKPKVKATQLLKRPKAPVRGVQKAVTKAPPAKEPQETRRAQVGKEAAAATTPKDSTVEAVASSEAVEPSASVAPQQDQGARAKAPQRNPTEKKQGRNTRRESASKESGKENSKSQQQPQPPKKQLPIQWASLLKKSPEEQSAVPPPSPPSNATAQTANSTPKIPKKKSADERIPEVQEAPVTPDVNNDVEALALAKAEETLKKLEISERIKVEQQLQHKLIQSSPRAEQPHMSPVQARLAVAEDPLPPVVMPKTLSTGIDATAMFSYFDEEPPKVNMWPAGATVGHYQQPSTNRRDYSKYPRSSHMVGGDDGRSNTVQHDGGALVTQNVGGVSQQDEVDTLHGDSSVQQEGVPDAGFQGHWQMGYYRSRYSNPKHQPFSYAYDEDKPKNYRQGASEHYSQKEGRHHLNGVYVNYGYQHDRLQTPPGLVSYYASQQPYYGFSNSTTQANPHAPSDSATSSMWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU3</accession>
    <name>A0A061DDU3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769880.1">
        <property type="nucleotide sequence ID" value="XM_012914426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDU3"/>
    <dbReference type="GeneID" id="24566235"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401850"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600826" evidence="2">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="22840" checksum="563FA1D7C03D189B" modified="2014-09-03" version="1">MVPRGIATVSAGLVTVAALAPLLALATVHTASQPSPSAVEDPESAIFREDVCHSDSHAPRSIGDDDVQSGAGLTGTWRGEEQASPAYADGYHAIVSSKDPDQLPSFEGGGGRSDHGEASREGNHVQITKLTLRQRRGRALRLIDNATESYVVDGHRQPLDSSHREALLLPAIQGSRLLSKGDFVDSMCSSRGTESECVTIYTPLAASRARGHALHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDX9</accession>
    <name>A0A061DDX9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768861.1">
        <property type="nucleotide sequence ID" value="XM_012913407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDX9"/>
    <dbReference type="GeneID" id="24565216"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305790"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="282" mass="31528" checksum="9AF8A1049B33ABA8" modified="2014-09-03" version="1">MVYTSLTDAPQNFKEAADWLLALKGDDVKNLEAIGEAVYKFLVDKPVGRIHLPALEKVKRISKDFLEQRELRNYWFVEELLKRYNDRISKTPGALAKCFRVVDDCDYKNVVKSKGITAAAIAEKLDRIVNGTEILLDNVKIPDEYKSAYSSEATWEKSCAKDPEACATVFVGIAPMLYAGVRCLHTATIAALLRLVPLTKYEIGLGKTMKALGYVEPESRTDMNMFEVDAALRDLYTSGVLTLCDFAGFWAFYGLESSVHEGEPSAEPSLRAKAREFFLGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE89</accession>
    <name>A0A061DE89_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0308340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769116.1">
        <property type="nucleotide sequence ID" value="XM_012913662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE89"/>
    <dbReference type="STRING" id="5866.A0A061DE89"/>
    <dbReference type="GeneID" id="24565471"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308340"/>
    <dbReference type="OMA" id="LHMGHYI"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="96"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="706" mass="80286" checksum="735A4CC79DF33F57" modified="2014-09-03" version="1">MSLAKRRPPRFVVQLHDRNISFVKSKDEPAEKRDEIEYFKDGRLHTAKRDPQAAEDANAPFKNAVALIETLQGSDAFGVDRLPNAKHNEQFDKMAGGLFNPGINICFMNVILQVLTHSPYLAPAMMRAAHSRVCPNAKRKIVCVTCVLEAHVKQALGNRVAKKNPYVHLVQRLIWKQYQLGRQEDAFIFLKHLLDALIKGCYGSRYSNSTATMVPQNDAMRSFIGRIFGGFLKNVLMCSHCHYRSEKLETCFDISVDIYRANNLADLLTAFVKEETLDHNNRYNCPKCKRHQKATKAMSIYRAPKIMNVVLKRFGMGATGCEKSKKEVSFPLSFSMSIHTSKQSKPVWLTYDLYAVVCHLGRSLHMGHYIAFVRGQHGFWSCFNDASVSTVSQEAVLGLRQEAYLLFYAVNDECAQICDLLTNDKAVTNTFTTKQVPVNRNLQTTTAHYRNDVLREDSLADDAETDNWPKWPLYESVKRKQPAEQQYKVSLMSPSSGTSTDSAEETVESNPESHNELDTSPKVENPQMDSLRVVKRFVTRRVHGHRLKLIGLFKQYQVSQDVIRDIMRIKEQLKGRRGAAADEEPQKQQVRESDDETHLRPLDTAADSDVDTWSDADPGDAYHQLKSSIHPELPKRSQEDVDYDRGKLKKVRSAPQPPLGGVQYVTHNSGTKIAVHQKDAFDSALGNRARKRRHAGNKRRRSRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA4</accession>
    <name>A0A061DEA4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770290.1">
        <property type="nucleotide sequence ID" value="XM_012914836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA4"/>
    <dbReference type="GeneID" id="24566645"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405880"/>
    <dbReference type="OMA" id="CNDASIL"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="25331" checksum="10F8E4C1E4D9B875" modified="2014-09-03" version="1">MAYTGRSPVLPDDMCLRGNPFDIGHFLRLFDGRRRNKRTISAFKSLKSIQGTFVKKDSGTIAPARMLLYGGCYRYLRSLSEPKFTVNAAFLRQLDNHGVLRYNQDDILAKNAAILKLMCGIKRTPEQVAASLIWRRCISLPSLELRTMFFKFISRYIEAMDMDDIRQLGRMLKILVDSPNDDLLRCALAGVPSKSDILVSKRVLMKYWDFVWNCHPAMIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEK1</accession>
    <name>A0A061DEK1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769606.1">
        <property type="nucleotide sequence ID" value="XM_012914152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEK1"/>
    <dbReference type="GeneID" id="24565961"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313220"/>
    <dbReference type="OrthoDB" id="10360846at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="294" mass="33339" checksum="B9D11CAC7A4C2AC4" modified="2014-09-03" version="1">MSVTRQSTRGRRQTPQSAQNYESSRRPGAHTSKDGPKKTVPEKPLEEEDAYMCDKLGINHSCVKNDMIYLEHLNEFATLQELTNKLENSTEIPRTDQIKDVGLCAVLPFANLVSPGFSNHYSTQYEAKPLASKCSNVACGTNYREVPAHSRAELIYVTPRQMYAIITTILGQLLHNDDEIFGDIDWKAVSIESHLPVSICKEFWWGFDITHIKDGYNGCFVRADKRHNFEAGGNYYSDLEVKAAHRANTVTQKRVRVLSVMNARMKANTQSSDINADPRKRPETPKRRNCFGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES2</accession>
    <name>A0A061DES2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769961.1">
        <property type="nucleotide sequence ID" value="XM_012914507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES2"/>
    <dbReference type="GeneID" id="24566316"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402630"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600320" evidence="2">
        <location>
            <begin position="24"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="388" mass="39992" checksum="4252973B8186D04D" modified="2014-09-03" version="1">MVANARLWCSGLLLLTVCRLGSAPCSRLAAALSKIPRPNGGGLHATGFLSNTQWVGSNLVASAGSMPRNVLRQSPVRNSTTNYSAKRRSDVRATNVADATATGTTNLHGANPGSVLGRLWMTLKRIFGGRGARGDGLKGTGGASDASFQLPNGASGGGRRVKRWQRGCGTIRTSGELTALSGHVNVRGAGALEGARSREEHCGRSGGDVLPLLRGNDDDNHGGTPGGAHTQHADDRVHAVERRVPLLPGTAAAAGACREAVGRGFVPGGDGHCRRAAEGRHHPELQHRQPTVVHQAPARRHSELAAREHHIGGARRHAGVDRHGGGVADGDGNGAATAAAARAARSHRIATSYHTANGILMRPAVLLAAGAGILPPRPRGQTGVTEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES8</accession>
    <name>A0A061DES8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">-Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769991.1">
        <property type="nucleotide sequence ID" value="XM_012914537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES8"/>
    <dbReference type="STRING" id="5866.A0A061DES8"/>
    <dbReference type="GeneID" id="24566346"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402930"/>
    <dbReference type="OMA" id="AHEDSIC"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600843" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114147" checksum="DF95BE6FDECF4279" modified="2014-09-03" version="1">MVICACLVAAAWTAVSAIAPPPAVGTLVTGFVAEWGFKSHKGERQLTRTLHSPVLHQSGSWNSRSYGRRRSSVNSNTNDILGGDRFLLFGDGGHDKILPTPKVSDNGGAKQTSHPRRHGVRPVGDDNSRVASTEIRAAAKTQARRQSGWDDAASEQPNSVDEVTVMYSKGLRENFTAVDPGHAATKHKSADAHHLAKPGNAGDENVSGQQESSRKQGNSHKEALYSQLVRLFESVGPVMRTDNAGLYDELQSFIADLKWDAWEAAAVSPDGIKEFYSLKLGKYKSLDMGFRRYLSEQMRRSKESLNTWPPILSNALTRLTKSLGMQHPLDVDEFLLLLDELVDRYHKHESERRSKVLHAIKDWLVNTAVAAVDFVLPLKPAERLVGALSITKSVFKWIASQILRHDGVYFTFNEFGLFKYYEMTKSYIHVPDGDSWPQDCQPLAPPGGGTWKLTFLGSGSRKASKTRVTSSIVFARSGVEHLWLFDCGEGSIIRLYATGYSDRRVRKIFLTHLHGDHSFGLFSFLSSVPGATPIEVYGPSGTAQFIANVLSSTSKSQQLRSLVVHELVAPGNEASARNERENSEKSFKINYLYPDDNMHYVAHEDDTCVVKAAPLVHTINTVGYVVQEKMVGQRYCTVGSPEPVVVSAESGDDDKCSKASVHTSQSRLPRKFVICQDTADSRLLQPLAMDADVLIHESTINMPTNAGSEMLLRLTRHVSSDPMKRTTMRMLDQLLQTEEMKFQMCHSTLSNIHYYYNRKIRALRDVIQRQETLDEALNHPDEAPEDNPASQPAAGGTNSTADNDNDLQEKRKPSWTTMVRKLIGELKLYTETQVAAKIVGNVVRLVALINELTGVSLAGKDQPKSRVMQRNMRAMASQLLRENGIQVDRKIDATGEADNSKASESIDRMAPLIFQYWSDVMGLQLPVLEQGNYSRLEWEQLYNAYARFNGHSTCLQAGEFASSIRARKLILTHFSQTCPDGPQSEHILTMTRIAHAALRGYRRHQAVKDGHKLIVGTAWDNFSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEU9</accession>
    <name>A0A061DEU9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770096.1">
        <property type="nucleotide sequence ID" value="XM_012914642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEU9"/>
    <dbReference type="GeneID" id="24566451"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403980"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="161" mass="17865" checksum="B36BB8507C42D488" modified="2014-09-03" version="1">MSGLLRHDCECDTGCVMGISCICCPWCCKKCKNNGNCKGCKPHYLKRTTYADPSYKCETFDCNTKCRGKESTCQCECCKKKCSSEQVTNCSAAQSPGHYTSSRADPHTASQQQLTDDSTSSPAILPIIIAAVPVALIIVVICVMVYFRIRPFHRVRYLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEV4</accession>
    <name>A0A061DEV4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770121.1">
        <property type="nucleotide sequence ID" value="XM_012914667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEV4"/>
    <dbReference type="SMR" id="A0A061DEV4"/>
    <dbReference type="STRING" id="5866.A0A061DEV4"/>
    <dbReference type="GeneID" id="24566476"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404230"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019562">
        <property type="entry name" value="Micronemal-adhesive-rpt_sia-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10564">
        <property type="entry name" value="MAR_sialic_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596089" evidence="1">
        <location>
            <begin position="24"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="445" mass="50288" checksum="8154D53DFBEF4628" modified="2014-09-03" version="1">MAGLLRGLAASICLCGLLASARPMETNVNFITKPTYLSYVEGLQQMIEKKFNGSNVITATLERWVKVENKHVHPFRQRGKCWYGFDGNVSQMQLDMDEYCAATNGGITMCARCENIETLKCYCVQMIMIDYSSDTNQCLNNCSSPTKCAGTAEILKTYKNVDPTVIKRLHHKYCVNSNLQRSLDRICGEGMAARFQDPDIRCFPKTALDYAHKSSCWDECGFTTECFGKPPESPSGRDFKPTEINWDDMITESNRSQFIKNYCRNIRKGHPTCYVTATTEETCAESSPKSKYTTYVEKTRLDMYLQPGSIFDLWITPYIPTYEISIRFSEEDKGCTGDLIADSPIVQSYASQPYDVYTGKWSLKYAKRGMDIHPALDGTTKTYQVIKGFKVMRDVNTTVNVCACLSSLLYYRYSDNMACSSASQFTIYLGKIHICGKLVPLYVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZS9</accession>
    <name>A0A061CZS9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766307.1">
        <property type="nucleotide sequence ID" value="XM_012910853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZS9"/>
    <dbReference type="GeneID" id="24562662"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104300"/>
    <dbReference type="OMA" id="SYTFWDM"/>
    <dbReference type="OrthoDB" id="336008at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057221">
        <property type="entry name" value="DUF7899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31789">
        <property type="entry name" value="OS05G0482600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31789:SF1">
        <property type="entry name" value="OS05G0482600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25463">
        <property type="entry name" value="DUF7899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="497" mass="56914" checksum="5A09F770EA52452D" modified="2014-09-03" version="1">MRDHMTQVTRIDVMADIPSGYPQPCYEMREVKEVLLVEHLACVLMRSGLARCYDARDGKLVCELNPVDRSTVHFAAVHTMVHNPSNDTLIIAYSSLPAHLQCKVVLLQSLKMGKLESYATSHQFECVVLRHPAFFEFCGMNKRIGAADLYKHVYRFWDMTTYELVFEIQGNGYQEMRVSDGVVVMLSQPRQNFIPLSLYDIEDGKLLVDPQLLNAICKQATREIEIVQHRELQFLELLVTQLLIKQQGGPIRAYDILRGEGFTVNDTNHFRPSGFVFYDVRQRAPADENDAQTNDSVDASEPTVFPRHKLAYRPRKFFTISRTCIEFWELTRYSLRRTRQLFIQGMDNPDICCHSLWANLLFVRAHQVQPFDENGSDEPLMERFRQSTIYFQKPLLRNRSDRVHTPTKAGPGCCEVDIFAADIDVYTKHSVLLFSLDGSSYFGKIDREVCGAHLRSLAVSQDLSVIACGNNAGIVRLVRMPNQIQNYHCQNEVSLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D021</accession>
    <name>A0A061D021_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766204.1">
        <property type="nucleotide sequence ID" value="XM_012910750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D021"/>
    <dbReference type="GeneID" id="24562559"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103355"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103355"/>
    <dbReference type="OMA" id="GPEAWNW"/>
    <dbReference type="OrthoDB" id="365042at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="234" mass="27470" checksum="CEC13B90832FCF06" modified="2014-09-03" version="1">MCAEMNQEANKERATSGHSDWYQQFYVHECDAECFFSSICHLLFYMSALIVGLQWFCERLRYSSPATVKTITQDIQECLLMLGRMLTSNEYVSIAVARCRAELLRYSHVISRFAPQLEPLRELVAAYNKNENWQLLVALITLAVAYSVCLWFLRAVTDYLRERKMLYFCVNMQPAGAANRGLYTRLMVEKLKNTPEFRRLKQQRMHQGPEAWNWQTRQRMGEPMPSDDMSDVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0A5</accession>
    <name>A0A061D0A5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleolar protein NOP5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0104120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766289.1">
        <property type="nucleotide sequence ID" value="XM_012910835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0A5"/>
    <dbReference type="STRING" id="5866.A0A061D0A5"/>
    <dbReference type="GeneID" id="24562644"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104120"/>
    <dbReference type="OMA" id="MGMRSNW"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000005">
        <property type="entry name" value="Nucleolar protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="6">
        <location>
            <begin position="285"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="439" mass="48651" checksum="FEFB2432E39A008C" modified="2014-09-03" version="1">MLVLLETPAGYGLFKITDSRLLECSVEDVPSFFRDGDSARSSVKLSAFSKFKTTENALEEATALSESRLGKQLKKLLNKKVVGAKVVEPLAVCDKVLAVEIQKKLKIDVVYNPSTVEIARGLKSQFFELVAGITESDCKSMALSLSHSLARFKLKFSPDKVDVMVVQAIGLLDDLDREANNFGMRLKEWYGWHFPELAHIVPDMALYSRAVRHIGIRGSTSFDDLESFLPKDVVDEIKKACEISMGSELLSDDLEAIVELAERLEEMLGYRATLEEYLRVRMRALAPNLTYMVGEVIGARLLSHSGSLINLAKQPASTVQILGAEKALFRALKTNAPTPKYGIIYHAGFVGQAQPKHKGRISRILAAKLALCVRVDALKDSQEPTVAIENKRYLEQKLLELSSKPDITSVGGIKRSDRPGQLQKPKWNASKRFKASNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0D3</accession>
    <name>A0A061D0D3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">WD domain, G-beta repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0105950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766472.1">
        <property type="nucleotide sequence ID" value="XM_012911018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0D3"/>
    <dbReference type="STRING" id="5866.A0A061D0D3"/>
    <dbReference type="GeneID" id="24562827"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105950"/>
    <dbReference type="OMA" id="PIAVEWM"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108909" checksum="42B1FB34C4AEC70B" modified="2014-09-03" version="1">MKGLGVFSPFAATSRCILCAPGYDDACGGGSPRPDANQSSLSLIGFEIKERAERPNSTFDLSFDANNNFSGFGNEVSFAGAINEFGTYDGARYGAGIADFTTYHKADVEGLDDKVASLVWMQCSGDNGIVGIGSTSGDLFLLDGTTIVEGDAPRVVSKTRACNTPLKRLSYNAKTNMLGIAGVDGQISVCDLANSVEPKVLDVSYGKWHVGLVTGLSWNKRLGHILATSGASVGASGSMSPSDSSGLVVWDLKARKPASSFRDPSGRMQPIAVEWMSEHMTQLIVGYGDDKSPAIQLWDLRNCTVPLKEVRGHTMGLTSLSICPHDPNLLLTSGRDDHTCCWTLDSVHGPFHPLGNMQTGALSHHRRIQWHPTAPGFFLAQDTDDELSVHSAMSMSLTESYMPAWIRRTCGVISGFASSVTTWTSAGAVNQYKLGMELDDDTARALDDSLELFCELANTNNFEAICRDRAATVTDEFDKLTWEVMGALHSGEAAALVNTLGYKLVEPKDEAVTQDYVDEQNDAPQPQTEGQLDGFGNEPLNEEDGEAFFSSLANKEASLADDPLVQSPVGDVHESEPPMSDEAPLTQTANYLSWGEDALCSRVIVGDYEGAAQLCLDKGKLTEALFLAYAGGLDLWLKVSDIITEKAQDPLLRALHLVMKGDVKAMVAQCPLDKWREVLVYVITNMMGDRDAYRDLCNVLGHRLYESFKEGNHKHLLPASIMFMCSGDVSRVIDCWKHLETGKNNIELVAKSAVRAAALWISVADDISKDHLGRSATMLAEAFVECGEVDKAVKCLSLPFVARDQYAMELLSRIRGTGHSVDFMEPKTQRREAAPVAPTQTQVPAKTAVRGPAEYGTAPAAVANAVYPGMPVPWPLPTATQQKGSSTRSTEDANRRIIATSAAVKPQGERMPSADLQFVTTVLGNLIAQGDTSRAAEDNRRRVADLMTSLSNGEQSAEANGLILNMCRAIHAGDRINANIILSTISTKLWSTANKNWIMCLKRIVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0V3</accession>
    <name>A0A061D0V3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766449.1">
        <property type="nucleotide sequence ID" value="XM_012910995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0V3"/>
    <dbReference type="STRING" id="5866.A0A061D0V3"/>
    <dbReference type="GeneID" id="24562804"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105720"/>
    <dbReference type="OMA" id="FALIPKY"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="391" mass="45075" checksum="B97B659D7350734E" modified="2014-09-03" version="1">MVDLTSNKAMTTTLDVVKPIRHINEVHHTRDDIIIQCVRLANVQLGIDVTGLDLQGELSASDFDYLVVDSITGGLTNILHKVTNTKNGMHVAVRIFGHKTDEFIDRSRERIIQHHLCLQGFAKHVYAHFEGGQIEEWLPGEAVSDADFHSYKYSHLIARQLHRLHTLPGQRELYLELHPHISAGVDVKFESDLWPSVWKFYNLCMANIEQLEPIIAGKFSLTELKEVSYSIRSHPNMKLQHIERMQTYCDSVRSPVVLCHCDLLNANVIINGPEEAKFLDFEYACFMERGFDIANHFIEHCGIECNWNDIPDEVEQRRFLVSYIGDIAADSDVDMLYMEIQPFFIAANIYWGLWGFLQCIYSSHEVDYPHYARSRVTSAIHDERWKLFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D134</accession>
    <name>A0A061D134_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0108290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766717.1">
        <property type="nucleotide sequence ID" value="XM_012911263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D134"/>
    <dbReference type="STRING" id="5866.A0A061D134"/>
    <dbReference type="GeneID" id="24563072"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108290"/>
    <dbReference type="OMA" id="KLVCITS"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="181" mass="20161" checksum="6C7CAA1266820AB8" modified="2014-09-03" version="1">MAELHSFHIFFRQRCIHRYLCSDAVVTAVKRCMTLDNARDKSSSAKGAERPATDSAAVADELAEYNHHYEKLLVGFMAGLSSFCKTIHVTNELERPNGLSVSYFNVCATSTFKIHYFETITGYKLVCITSPEVANLELTMSAIYTDLLVTMVLSNPLYTVGGVIDCPEFEDIVAKTLRANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1B7</accession>
    <name>A0A061D1B7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766614.1">
        <property type="nucleotide sequence ID" value="XM_012911160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1B7"/>
    <dbReference type="GeneID" id="24562969"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107352"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107352"/>
    <dbReference type="OMA" id="HEDFSWR"/>
    <dbReference type="OrthoDB" id="366349at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="149" mass="17004" checksum="1143ABC7F7D40EA1" modified="2014-09-03" version="1">MCASDATHDPSLRWADELDNSDSDLDGALEVTVKPTHLKEPSIKARQWSAPAPERQPKVVECHRADFLADDLGDSRDGFNRRMSRNQKKGNGRKDRFESESHEDFSWRCSSGSLRGSGSNSFPMNSKRDDDRGFYNMNHRRKEENSSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1C1</accession>
    <name>A0A061D1C1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0107357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766619.1">
        <property type="nucleotide sequence ID" value="XM_012911165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1C1"/>
    <dbReference type="STRING" id="5866.A0A061D1C1"/>
    <dbReference type="GeneID" id="24562974"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107357"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107357"/>
    <dbReference type="OMA" id="IDHGHIS"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43239" checksum="2EADA29C147822A2" modified="2014-09-03" version="1">MSTLPCVIIDTGSLYLKAGLSDQSEPQVHEQSVYGEVKKKYKNELPDERLYGNDCMKQMGYMSITPIVDHGHIYDYDAAIGLWKHTFDALGMTSQGNSVLLTEPVLCSPEHHQKTGEIFLEQLGVDDIHMSISGLLAMYGAGKTSGIVVDIGDGMVQVVPMEEGHLQKSAIRREDFGGMELTMYMQRLLCELGYPMTSREDFATCRRMKEQLCFCSLDPRTDENKVAELEQEYVLPDGQTLRDGETNTINISVERFYVCEALFNPKIMGLNHVGLANLVWESIQNSGLTQRRLLMENIYLCGASSQFENLHERLKFELQNMAQPGTRQCIAVYTSRDQHLLSWKGACFLGAPEVRNTYKELWVTKADYEEEGARAFQRQVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D224</accession>
    <name>A0A061D224_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Set1/Ash2 histone methyltransferase complex subunit ASH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766864.1">
        <property type="nucleotide sequence ID" value="XM_012911410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D224"/>
    <dbReference type="STRING" id="5866.A0A061D224"/>
    <dbReference type="GeneID" id="24563219"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109760"/>
    <dbReference type="OMA" id="WYFECKI"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="321" mass="35676" checksum="C73EF528C4B5D6CC" modified="2014-09-03" version="1">MERGRKLVDLASEAKRLKIIWMPDLEYNSFDIRYCESELPARLSEDRLTYTGSTMWCTALSRGCATTGNWYFECKIQEPNPEWHEFRLRGWDSVGTVGALLESTPQLKDALKPCVRIGFGTRLSRFDSPIGVNAFGCAISQNGGHIMYDGRDVSDSDDQGFDLKVGDVVGCAIKLNTPTASLADPRGIAAMWPFVRKALLCDVTNPEAMNAAMVPNAGAELRFSVNGVWRKTVITKLYCVEYHPGVSTFMGGCCTLNMGPEFVYAPPDDTYRPANDMGNSVYPCKEELLRFWMLGDTTVLSKGATINREYYKSIPADEMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2G3</accession>
    <name>A0A061D2G3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766969.1">
        <property type="nucleotide sequence ID" value="XM_012911515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2G3"/>
    <dbReference type="GeneID" id="24563324"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110800"/>
    <dbReference type="OrthoDB" id="366086at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="185" mass="19982" checksum="5A2A60C465065DA7" modified="2014-09-03" version="1">MNLRQCVDCLSLRCESLDEMALQRISYLLASRHTVLDITPLLNMLCATATASVSDGDAAHVAMCIKRHREDASVTIRGASVLNRTCCTTKLRHSTAQRLELALSLADRHLVVLDDASMLQRRIGKHMQRIAHCVHQAGGQRAASTVDAPVIAARSAVLDYAACFGGSTAHRNGKLHSALLNADQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2I8</accession>
    <name>A0A061D2I8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0110960</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766984.1">
        <property type="nucleotide sequence ID" value="XM_012911530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2I8"/>
    <dbReference type="STRING" id="5866.A0A061D2I8"/>
    <dbReference type="GeneID" id="24563339"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110960"/>
    <dbReference type="OMA" id="LEHEWIR"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000568">
        <property type="entry name" value="Calmodulin-domain protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="52"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR94798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="505" mass="57442" checksum="779A1373B3B5C9F4" modified="2014-09-03" version="1">MAEKFARLRGNTENSAAKAGESVGSAKIRASSLKATPGMFVTCANGSFRDNYKAVKLLGKGSFGEVLLCLNRETGQQYAVKVILKSSVKRKGDHESLLREVNVLKSLDHPNIMKIFEFYEDEKYYYFVTELYTGGELFDEIVSRKCFSEQDAAKIIKQVLSGINYMHKQNVVHRDLKPENLLLESKEPNANIRIIDFGLSTYCDLNSKMKDKIGTAYYIAPDVLKGVYDSKCDIWSIGVILYILLCGFPPFNGANESEIIKKVQTGKYTFDLPQWRKVSESAKDLISRMITYNPAKRISANEALEHHWLTYMTRDYGVDLPSLELSINNMKSFYYTQKLSQAALLYIGSKLITKEESNHLTTIFRRMDTNGDGQLDRNELIRGFSEYLHLKGSPLDDSEVVKVEEQVDQILQDIDFDKNGFIDYSEFLTVAMDRRNFMQKERLEKAFKLFDADNSGSISSAELGKLFGVTDVSEEDWQRVLHEVDTNNDGVIDFAEFQAMLSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2J2</accession>
    <name>A0A061D2J2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNARE associated Golgi protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0111010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766989.1">
        <property type="nucleotide sequence ID" value="XM_012911535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2J2"/>
    <dbReference type="STRING" id="5866.A0A061D2J2"/>
    <dbReference type="GeneID" id="24563344"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111010"/>
    <dbReference type="OMA" id="FIFAHIH"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF59">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="121"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="304" mass="33763" checksum="801252B0C99DF26A" modified="2014-09-03" version="1">MVRWESRSHAGTPRGAHGKDHTTVIADPETFNNEGISDDVVSSAKRPLLDQFPADPQPNPWLPRIIIGLWLVMTPLAIYYRKEITDFVRAVAVKGAEHGSLLYVYFVLLFILAVLCCVSLEIMIISGGFIFTHLHGHIKGVLIGTGLSFVAYFITMLICFLISRYVLKGIINRYLRHYKYYGALIRATELEGLSLVAMIRLSPFFPPTIVSYIFGSTNVSGRQYCLASFAAIPSIAFFTYIGSLIENLSDENNPPKSSTEIAMFLTASILITVAGVYYTYMVTKRHLEPNRSPRPAADAESVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2W8</accession>
    <name>A0A061D2W8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0107356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766618.1">
        <property type="nucleotide sequence ID" value="XM_012911164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2W8"/>
    <dbReference type="STRING" id="5866.A0A061D2W8"/>
    <dbReference type="GeneID" id="24562973"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107356"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107356"/>
    <dbReference type="OMA" id="YVACMEN"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="516" mass="57384" checksum="231E19E58C2CA29F" modified="2014-09-03" version="1">MSEQQPGCPEGAPSSHIASPEAADERHNVTTVSLGELSAFSRYNAAHRPLRRNRGNNQQQTDPTLAPGDAAGDCEPHSPENDEKSATSATAGDEYQPGSQAASADGTFANTILDPNVDIASVAASSYTSGAEALSVHKSALPVRAKDTLKRTAACRQDWRANAVSTVVKDPIVPYQDVLERIRANYKLKELKEEDYVGCLETIIERDYFPDVVKLRMTNVLLEAEARGDTATAAVVRKRLEEHESGQEMNVNLKTLGNESVSINIGKGGLKLDQFSRIFTSEDNRSFGRLMEQTIIRNNARSRWMEEGEKKHNLALADTQQKTNLGIPDSNVLSNRAVSRNALFFNQSEGRTAEKSQAPLIRSANTYMPPDYEVRLAELDSKQKARRLEKVKDTYHGKVNDLITQFGFRECKELVDHEQMSKFNFVHTPLTAPGDPHEYAVPKPIPREELAEQLRKKYNSTSARTPMSKTPSCRTPLLVQRLIEKHNRGADMQLRESYSSSKRSRGSVRSSVFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Y6</accession>
    <name>A0A061D2Y6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767322.1">
        <property type="nucleotide sequence ID" value="XM_012911868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Y6"/>
    <dbReference type="GeneID" id="24563677"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202930"/>
    <dbReference type="OrthoDB" id="366586at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="18512" checksum="D1BC313997E59547" modified="2014-09-03" version="1">MSLFSRFSGLVQAGIRAARKTVSSAAKRGIESLTDSAFDGAIDASSIKSALESPGVEELMDSVIQMVMWYVWISYVIPMMLIMGFLFGLLFAAYFYGWLNRCSAGFFRSFTIAAEIIMYAYWRLKKALRAFWGAYTEFDDSGLISKFRGRRYLPAKFAKYNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3K6</accession>
    <name>A0A061D3K6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-fucose transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767354.1">
        <property type="nucleotide sequence ID" value="XM_012911900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3K6"/>
    <dbReference type="STRING" id="5866.A0A061D3K6"/>
    <dbReference type="GeneID" id="24563709"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203250"/>
    <dbReference type="OMA" id="VGCGEEY"/>
    <dbReference type="OrthoDB" id="363842at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="359" mass="39716" checksum="DD0539200388D9B0" modified="2014-09-03" version="1">MDFEDLKIFKSWEQVKPYFTNPSLITVEALFILLTLCNVYVVHTLFVTVLPAPVFITWWQLTQGLLSAYILGDFGQMYPKMAYFPSVKIELGLLKTLVLPTIAYVAMLCSTNIMLCKAPSTAAFPILASGAVAAHHAARFIACGEEYMPMRWKAIGFLVLAFVLGATDKHIAPGNIMTVALLYAFLAAVFRAGFMERALHIVGGRGNALHNHQHLIGAMILPVVWIVNGELKVLIRDLPWDITAAKTWQVWGCFVAVGALPFVKNVVSNRLIRQTGQAPWRMLELIAVALLFIIGSCKQAPSWQVVLATIFVIIGRFLGAVDVIRNLQYAREPGTSMGHQASEPFLQKDEAALVQEMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Q2</accession>
    <name>A0A061D3Q2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPOC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767512.1">
        <property type="nucleotide sequence ID" value="XM_012912058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Q2"/>
    <dbReference type="GeneID" id="24563867"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204840"/>
    <dbReference type="OMA" id="TNLVWQG"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd21546">
        <property type="entry name" value="SPOC_FPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spen paralogue and orthologue SPOC C-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="27934" checksum="17779AED345670D9" modified="2014-09-03" version="1">MEIRLCDFLRTQAPHIFERPRSTSPSSYTSHGDRGEGRHYHDRGRQRNDQQYADTSRSEREPSSNVAYNRFSDNAASHKAPEKQTQPIWRGKIARNGKKLVDTIAIAISGQPEAVLTKDVNTINITHRLKCEDAAKVEPIAVFYMKARRPEQQRALEDYITYFQDKDRIGVATLDEDTNIYVCAPGTELFKTHAPHGGGDSTLIGIAVPSTSPTQEESADKAEPQQPEERRDWLNQLNTLTAMLGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D427</accession>
    <name>A0A061D427_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIBOSOME BINDING PROTEIN-1 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766978.1">
        <property type="nucleotide sequence ID" value="XM_012911524.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D427"/>
    <dbReference type="GeneID" id="24563333"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110890"/>
    <dbReference type="OMA" id="WITLREG"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1433"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="638"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="759"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1433"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1780" mass="198844" checksum="7A681A6E03A8928B" modified="2014-09-03" version="1">MAAKGSVPDFKTLKECLEFLEWLNDRKRSVVRSQVANRLYRLLKDKYEGVDQTQIEIALSQFLNNLSVFHKKLCTSPRGSYTGEKKTKPALNALLACIPQILSAFYFLRYHVDRNFAALGGGGWADKEVGVVSMYATIGMRLDALMNLVTDIDKYLVAKSNNVYGVIPGGFELSELKIGYRYPMGQGYRNGTDMAGDLQKILDKNTNANNLFLDVYSTTVLSTSGTQIPNVANAIRLVRDFCRIFAEVRDEQDFKGHLYSKDKCIEWEKLKAHCAGLIGPLEKIFKQKHFSFTGYARDLDKLSKQSIAKKMASWFRTNLSEVIKNLDNISSFRTNVRVNERLFNRNALATKDRTALTKYFNKNFFPYGFTFYGHDAGTGSNRFQILNENWDGVIKVLKEKSKGLNELVNILNGDICKLKKNKERQPDEPKDGVPQPPAEKSEAESDVESEDEADEPLQDEDDPPADTKTEAAKSVVTKAEAAKPTATKAQSAVDGNDQTQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAHSGASDSNTASGPSSGSGGGGAGGGERPGSDSSGNSTTCPGAISYNFGSGYGKYCPRNDKKWDLSAQQQIHEKWDKDKNEYDRKMAQIREQDKEKLRLQKAAETRRLEEDERRKQAAYEKSILDRQISMPYLDGQNVFSSTRATDLGGLVGTMVPDDYDNGSDLIMQQIAAEQQWEKQKQEGTVQRQLDNYAAKQQHKRKQAAKKLEETLKDTAEDIWKFQQQKYVEEIENNVQDPDAKHRLQRNKKLEKQNVGDYPPTSTPSTIPRQPSRSDLGHSGQNTGGRNSNGRGYYEPGEGRGRRYGDIGFQDVDGPIYLGGESIEEDNYVPSWFTNGETPPDPFITNSVEDWKKALQDGLSDRKLDRDYSKLIEEQKRDAEKRYRMNRVLQKVSVDVNEGQKKLKDDADKEAERMIQDSKYNDAIKRLGIANLQREADAKALQQRLDEARKDQDEFIQKAQSLPHAIEGNAIDTIRYPPAFVDHHLYTLNPVVGTVVSQDSPRKRIMQEQYEAARRNLNQYQNYKDQMEQRKLLQVAKDWIQKPKDEEAEWTKRRIYGTQELSVGGIQTNIPKGHTIDSSSFDVMKLSDGARMKFSDVTATVVDHVEPEPQITQAIGDATAESKGIPKSMTLQSPAFNAITMGHPIKPPKIPSTSAMQLLPAPTRLTKPIRMKPTGIAMPAHKHPPILRHVPITTQTFDDPSMAKFLNISSTSLTNSSKADTNVPVLQEIERPVPQSMFGGSPVPDAELPSSPIPRDTFLTEPQPTMGFQIEFPKRTVRKVDPEIGLSIELAHHGDRTFNDVDLDDPYANTADILKDEFKPPEDEGFSGLPNTNLDLNFAPERIGLEGYEDPGMPRDSPREADERVINPFSTDECQNPWSVDTSSTDTPPPPASPSPDTDHLPPPRTVREMLYWFVGLNTYGFIGMITEYVECLLKNANKNVFDMPDALEVTRDPYNLNSSHVADKLTEASLYSATVIYKITHNNDFKAFSNFNFKSVYSQLHYSSDPACLLCQLRDYVYACCHQLAFLKAQCKRGKSLGGWQDSKYGSDIKTSSPLHSFLTDGWDSTFETHPFDPCNACLKSRVRMGFRKDDLPEKSENGITLSTILTPSCGGDNPLLTLSSYLNCLTRRTPRTTGELVSYFHNFGIELHGSDPNELNSLSIQRDLMSISLHDVATALRCRLAGLLSCRPPVGRLCHPTWITLREGGCLDINVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D465</accession>
    <name>A0A061D465_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767722.1">
        <property type="nucleotide sequence ID" value="XM_012912268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D465"/>
    <dbReference type="GeneID" id="24564077"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206940"/>
    <dbReference type="OMA" id="HAHENDE"/>
    <dbReference type="OrthoDB" id="365243at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="333" mass="36622" checksum="9BF1F65E88870363" modified="2014-09-03" version="1">MIRKDVSGRRRRFGAAGDFHPDNATNKTSSVGSIASSPALSPSFHRSLLNLQKQLPSRVNNKEDDELEYIRVLRSCLSGAAVDPSSPCSISTAGSDGEETAAEPQRRCYSDSSPYTTFQRRQRAGGRLYAERLHSSEGKQFFGVERKSRTEHVERRDVAEIDGHESATEVFRETPYDSDARAAYPVYYEGSETSVRHTPAGNTNVILLDDGNNAGVEVSLRKLRTGMQGQQRLIRLHRVGTHLQLEYSEAVEDLELSFVPTKAIATRHGDRYQNVEQVPTKRPSYAHRTSTCANDHLIATSPVGMTALCVVSGVLGAAIGAALYFRSRSSSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D468</accession>
    <name>A0A061D468_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767023.1">
        <property type="nucleotide sequence ID" value="XM_012911569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D468"/>
    <dbReference type="GeneID" id="24563378"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111350"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="9928" checksum="C3AF125688BD0CD1" modified="2014-09-03" version="1">MHKPQAVNQYENDDGYDEGDDGDDDDDDDGEDGHLTAHIPHPVERPDAEVDHDADDDDDEGYGDDDVRGGNYGHLTAHVICHQRNHYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4H0</accession>
    <name>A0A061D4H0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767812.1">
        <property type="nucleotide sequence ID" value="XM_012912358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4H0"/>
    <dbReference type="GeneID" id="24564167"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207810"/>
    <dbReference type="OMA" id="YPQLTNY"/>
    <dbReference type="OrthoDB" id="360523at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="633" mass="67315" checksum="12628E3471BB219A" modified="2014-09-03" version="1">MYPDGEIGGASGSRGQSADGEAEPSSAEQQKHEPSRYAAVLYRNVPGAAPDISQSNDGDALRLPAWQAGSSSSSTSGALLPWQDIYEPYGKFLNGTNYNACTPPLQSLPSGNVLTFAPSGSAASDGSQQSGSSGTQNANGISNVGVNPVNRVGDVTDAYGLFPPRLDRAVTVSELMKLTDAVNELTKRMPLPPTQELLSAIEPQLAMTLQLTYLKAYIQNQQLLIDIKNGILGGILNGCDFRNSMRLAVPTLDPPPPMEQQQFNTPYYGCSDGQGMAVDGMCDVAWAQPPAIEYPMGEGSPPSNPAPFPADGGDFNSSGTPQFPPFTEVFEALQQTQFLPPMIEAPPPPSGELLASTVLRTAQPTATASSATLAPESAPTPGATAGDGYETGGMEVAPPKNEIPPIPAEIRNMVKYDGQKHAFVAVYLGPLGARRRRLFSIRKFGVEGALKLATDFAVGSTSAAVASKERRLLEEVCEVALRANPASGSCLDHVEEARAIPETRGIVFSCGAQLWMVITYDAVSGERSIEAFSVQSLGFQGAYQAAVAALDERLKNGAMTSKLSGPIYFWLEGTVGKAVLCLMVTPRDLMRQSTCEQELYIGRFDVTKSGGFNSARKLAQKWRSELRNVLTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4U5</accession>
    <name>A0A061D4U5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767907.1">
        <property type="nucleotide sequence ID" value="XM_012912453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4U5"/>
    <dbReference type="GeneID" id="24564262"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208750"/>
    <dbReference type="OMA" id="WNFSFAY"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="65" mass="7711" checksum="04D461BD43D26458" modified="2014-09-03" version="1">MRNVQRVAAPPGYRWTPQHFVEKIREKPVDFITLLLFIAHILGFFCLLIVLKVRHSRRKLFAVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4V1</accession>
    <name>A0A061D4V1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767912.1">
        <property type="nucleotide sequence ID" value="XM_012912458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4V1"/>
    <dbReference type="GeneID" id="24564267"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208800"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7542" checksum="75EBB9FCB2C4794D" modified="2014-09-03" version="1">MHRLDNVLEQLSALSNTQKCQPQYTAQWHLVGVSLEALLKRYFSSAGAPPAICPCNRPRDRATRMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Z4</accession>
    <name>A0A061D4Z4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767824.1">
        <property type="nucleotide sequence ID" value="XM_012912370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Z4"/>
    <dbReference type="GeneID" id="24564179"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207920"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="8246" checksum="75F522C5DDF4AE5E" modified="2014-09-03" version="1">MRFLTRCINRLELVMNNGEDTRKSVVKLNSKSDNVQLQGIGAAFNEMRLWQHIGLDNRRILWSNQSPEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D515</accession>
    <name>A0A061D515_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0208120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767844.1">
        <property type="nucleotide sequence ID" value="XM_012912390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D515"/>
    <dbReference type="GeneID" id="24564199"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208120"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="116" mass="12926" checksum="3FEEB2AD51EA0189" modified="2014-09-03" version="1">MGRDRRCISLQGCGVTYASDELFKPETTKLYDADAQSQFGCKIDLQTAGEAAFYCPAPYVLDPPDCFNQVYVVAEVKNVIDIVLLLIALAFQHFVAVRINGQLVRPDEMLRQTPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D521</accession>
    <name>A0A061D521_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767849.1">
        <property type="nucleotide sequence ID" value="XM_012912395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D521"/>
    <dbReference type="GeneID" id="24564204"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208170"/>
    <dbReference type="OrthoDB" id="37153at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="52" mass="5901" checksum="86D225D4ADD11F54" modified="2014-09-03" version="1">MGRGLRIGGSLKREGGVFVTFRGLVNRRSLQVILRIAIRCVLHRCVSQDIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5G8</accession>
    <name>A0A061D5G8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768152.1">
        <property type="nucleotide sequence ID" value="XM_012912698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5G8"/>
    <dbReference type="GeneID" id="24564507"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211130"/>
    <dbReference type="OMA" id="ARKCKRL"/>
    <dbReference type="OrthoDB" id="415302at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="226" mass="25569" checksum="E7D9687B0C4B8AF2" modified="2014-09-03" version="1">MRFCNYARRLFGAVPSSSQPQCHPEPGFKLGCSSIATSWTQSILRREFAAGSAAKLNAITSALPGKNRMLTKAELKNFPGHLQRYKKYGGLPEFHNVDRNSHGFIALPTDRFMLVLTTSKNNVHAQLVNRSRDKRTVFGSFAGNVGINKKQQQTERCAYRIGENMAKKCKRLGVFAVDVKFRRLMRIETVLQAFQAEGLQVGQLIHEPRLPKTGINSVRPRRRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5U4</accession>
    <name>A0A061D5U4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768114.1">
        <property type="nucleotide sequence ID" value="XM_012912660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5U4"/>
    <dbReference type="GeneID" id="24564469"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210780"/>
    <dbReference type="OMA" id="PEHEMLW"/>
    <dbReference type="OrthoDB" id="359909at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="127" mass="14578" checksum="6C191C0D649E7994" modified="2014-09-03" version="1">MSSMMGSAGQRRGLALFARASANLNSKIPKRITSKHNQKPLGSYPFPPEHEMLWKNRRNVPGGYFHQAVSPFQLKFCYPLIHQGYARIWAKGSQMFWWVIWPTAMAITGFLSIDAINTKYLKRIGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5X1</accession>
    <name>A0A061D5X1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sac domain-containing inositol phosphatase 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0106130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766490.1">
        <property type="nucleotide sequence ID" value="XM_012911036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5X1"/>
    <dbReference type="STRING" id="5866.A0A061D5X1"/>
    <dbReference type="GeneID" id="24562845"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106130"/>
    <dbReference type="OMA" id="NFLQWVV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="4">
        <location>
            <begin position="126"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="779" mass="89133" checksum="FB8546F01EE94759" modified="2014-09-03" version="1">MDSLKRGWVFQTNEKVTILQTDYRRVTFFKNTPDFTVDVYESKKFDKRSFLKGDYDCPGTLVSDCFGILGIVSFTEGPYLVVVTDAKKCGTLIKEHDVYSIGGKILVPLFYPCSENDMETYYCNLFNQFDISNNFYFSYTYNIANSLQRNVMYATCTREDETWLRFDAVCATQKYRYNFVHAKNFAEHFGRDSVGLCLTVIHGFFGQTNVCLSGRILAVHLIARRSRFYAGTRYKKRGISSDGHVANDVETEQILDDATCTASVFSFLQVRGSAPAFWAQDKSKTIMKKPPLIYTQNDPTFTAQKMHISELLSLYGSPIIMLNLLSDDPGTEEGKLSTQFQSAISSINVELPRTIRVQYVHRNIRSALERGNIRQMIAEVVEHTAGEVGFFHERKGNICNLQLGVLRTSCLDCLDRTGVMALELGLFVFQRQLALLGIHVKTAEGMCDYEVHNFTDETPSNSLNTSVVPELEPLVYLFKGMFEGMGDALAMQYAGSKTLRKYEGPRGAISRSLQLFTTLKRGFSSHFSDSDRQTLSNIFLGVLRPEKHPPPWLVDVDKYVHHEKFLCEYESVEWWVVPLMCFLRRARKLQSNVCRSWFDLFDARGEYLPWVMFAQLVASVQYSKDEGACWRRYAYHSSEDKEKSSLVDTAIRHNFSVIPIESHVSRSNSENTEYVELRAGLPPGVVLITREDSEQDELSSAVPYAPGDSTEAVMVNAQSAYQDAFNFIRHTRKRNVHRMNSFLEPWRIQPQNRDEVTRDLSTIRCRVCDVERYANYVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D699</accession>
    <name>A0A061D699_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767728.1">
        <property type="nucleotide sequence ID" value="XM_012912274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D699"/>
    <dbReference type="GeneID" id="24564083"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207000"/>
    <dbReference type="OrthoDB" id="10500165at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="7956" checksum="3ACCB6B392122DBA" modified="2014-09-03" version="1">MSLSTSTKSRIALCVVSGIAVYLLNYVLFRPIVLTSDVTSTYYLDSIKVSAAVTGAAVIFLSTIGLALGWCLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6A6</accession>
    <name>A0A061D6A6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0212300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768274.1">
        <property type="nucleotide sequence ID" value="XM_012912820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6A6"/>
    <dbReference type="GeneID" id="24564629"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212300"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="138" mass="15335" checksum="585AADFE56D57A23" modified="2014-09-03" version="1">MRTRSSTYDCNPSPCNFQCKGNEGKCQCDCTCCEKKREAESKRLAAASLHSTSLHSPSDSSDAQSHVAKQEYPSPSEDELQENNSQHFSISPNTIAAVIVGIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6B7</accession>
    <name>A0A061D6B7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766660.1">
        <property type="nucleotide sequence ID" value="XM_012911206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6B7"/>
    <dbReference type="STRING" id="5866.A0A061D6B7"/>
    <dbReference type="GeneID" id="24563015"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107720"/>
    <dbReference type="OMA" id="NAEWAHF"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211:SF14">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="347" mass="38819" checksum="636D0B6F0DC34779" modified="2014-09-03" version="1">MSRVLTIGHRGMGCSIPGTLALYPENALSSFREALRLGVQGVELDVFLSCNNELLVIHGHHAKASLCLTALRRDASSGAQRFGLEETVEKCDIRASDLLLRKPWRVLNQDESVESVLEKHRSDVDASFQSYMEKMDVWEGEYVPTLEQVFQEFGDKLIYNIELKGTRPEIGEHVLNLVERYPQIKVIISSLNWLPPELSPDSPYGEYDIERLPNGKVPADLLRPLINNRLGLPIGLLFNNERSDLPSIGRILECAKTFGAQWIIVAHDIWKSALPIVGCAKTGIETLHHLVSEMRSNGLKLMTYFLESQPDAPEDLRLHVEAGVDAICPNDIEVALDIIKKSCTSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6C7</accession>
    <name>A0A061D6C7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0301450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768427.1">
        <property type="nucleotide sequence ID" value="XM_012912973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6C7"/>
    <dbReference type="STRING" id="5866.A0A061D6C7"/>
    <dbReference type="GeneID" id="24564782"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301450"/>
    <dbReference type="OMA" id="FDEAVFN"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="212"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="400"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="570" mass="62978" checksum="26BE9E4E596F27C3" modified="2014-09-03" version="1">MVLGLGRVNGVAFIGRASHRSCDGLAARRLPDCIGSSICTFGISGRPGIGAYGEQYAGSGYDYQGGYSRAPYSVPVNTAPAYNANYGYSQPSGRHHTYGASQYGYGGYGRRRQPYGTYNGNEYFMQLPTIDWNLKPLVEIKKDFYDLSPEANNRPGEEIEAILESHRIIIDGETPLPKPVNSFDEAVFNEPIQNIIKQMGFVEPTPIQKVGWTSCLTGRDVVGVSQTGSGKTLAFLLPGLLHLLAQPPVSAGMGPVILVLAPTRELCQQTYAEAQKFMRVMNLRGAILYGGASKPQQQQQIVGGVDIMVATPGRLLDFLSSGVVRLDRVSYFVLDEADRMLDMGFEPQIRMISSQVRPDRQTLLFSATWPSSIRRLASEFCKNNCIYIQVGDKELTANPNIAQQVKVLRSDETFPYLCTFLSGEGYNKKVLIFVESRIGADNLVRDLSHRGFSAISIHGNKSQQQRDYAIRQFRNGSINIMVATDVASRGLDIKDIDYVVNMDIPRSIEDYIHRIGRTARGTNTGGALLLLVSDYPDHRKAKFAQKLVEILHGVKQPVPPELQHLAQSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6C9</accession>
    <name>A0A061D6C9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767758.1">
        <property type="nucleotide sequence ID" value="XM_012912304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6C9"/>
    <dbReference type="GeneID" id="24564113"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207280"/>
    <dbReference type="OMA" id="SEPFWGY"/>
    <dbReference type="OrthoDB" id="365507at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595833" evidence="1">
        <location>
            <begin position="25"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="368" mass="40890" checksum="442AE9F63F9CF8F0" modified="2014-09-03" version="1">MCSWLAVACLCALAVCRLESRSTARNPRQRWDGSPVCNKPCPVLSSAIPAAVGITDLLGRLDRHRAATALYRQLERIPVYIATDARGNALVSHYPLDEVDAAAYSATEPPPPAAARPAKHLPSAQHAVQEFLQQFAEVSEVVPVQSSTHDLRSMNRRMPAVLLYFMDPNACAAHVLELRRQGKEAHITRLTLADYAKQVDDDARKFDPILLPTSEALVSATRHGRGTFRGTPIFTTDPPIAITKSETAQGDFNPATERLAVFFSPESAAEIYRRAWWKGSVKLKLGGEAVICRILPGTRRWSTRVLVSSLEELCDRIKTDEPYWTSLIHFEPPPIAADTHAQRLLQERANQLKPTWDVLRSLRGLLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6J3</accession>
    <name>A0A061D6J3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD domain, G-beta repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0207910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767823.1">
        <property type="nucleotide sequence ID" value="XM_012912369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6J3"/>
    <dbReference type="STRING" id="5866.A0A061D6J3"/>
    <dbReference type="GeneID" id="24564178"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207910"/>
    <dbReference type="OMA" id="LNEPICY"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="4">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="396"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="439"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="533" mass="60510" checksum="691BE2C3B00941EA" modified="2014-09-03" version="1">MLNTAYWGLPEAATDVNALKEFELKHKIYSLQVGITTNDLEVKVILRALIEPITVFGEGKYERRERLKKVLLYKYDRLFHDKDVANAITASSEAKNLYDVMKAFNIDLSNVFSKKAVFSDLAHQDQTQDAADKELFYTEGDERIKHFRSELANETWARTRKRKEVIHEYRNSTDQFEHKDDVERYASYLTDSLSLAYSHIAAERPLTAAKFAPNMKYIAVGSFCSHINVYHYKPDDNFPLARKLDNGSKEMIHCLDWQCNVNAIYDKKSAIDAVQDHELLLATGGSGGSLSIWRPFPESETEQNPDFCVHKTNLHEERVNRIRFHPFKQVILSSSTDETVRLFDLQGMEELYVQEGHSHSVHGLALNGDGNLVASGDMHGVLIIMDLRTGKHIFQQPVHNGKITAIDFHPINNHIFATAADDNAVKLFDLRKMRPGSSLLAHTKLVSDMEFEPTYGRFLATSSFDTHLKVWDTEDYKCRKVLSNNDAKVMSVNVAPDSSAIVTACYDRTLRIFKPIDASDSSITTGLSSIIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6L8</accession>
    <name>A0A061D6L8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768389.1">
        <property type="nucleotide sequence ID" value="XM_012912935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6L8"/>
    <dbReference type="GeneID" id="24564744"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301080"/>
    <dbReference type="OrthoDB" id="366331at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28924" checksum="F34C04D7578A441C" modified="2014-09-03" version="1">MEAYKRRCIKRYQYCDLASAIFDGYLVYYIVRQVDITGRSKAMIEIFATWFRIVFVVKVLLHLLVVPVFVFTGSVSKICLTIIPYETESIMPIVLPDAKSSSSEIPTTPSARAVLTYKYTEKAKLLFQTFGLVCFTALLLTLDHYLHRLLDITLMAMWFCAVSSATQLHYVYFRDYSPCRESKQGESELLHPRIKCMWMLYTVTMIAGWSFGNYLALLDWDEPYIFFPNANFIGMCLGHLAAAILTPICSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D713</accession>
    <name>A0A061D713_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767968.1">
        <property type="nucleotide sequence ID" value="XM_012912514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D713"/>
    <dbReference type="GeneID" id="24564323"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209350"/>
    <dbReference type="OMA" id="PENTGCM"/>
    <dbReference type="OrthoDB" id="361007at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595851" evidence="1">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="347" mass="39592" checksum="DEA2BC0125EC4815" modified="2014-09-03" version="1">MRCTIVLALVVSSQIAIAAPGNKKQQQDDITVTGLVVIKDRTYRATCNCPAHVKSLENMIYISRGLCYPSKVKVRTHGVHDPDEYKLLVDGMHLIPHEDFTSVHQHPLSAMDGRVKGKAFYAPGGDLGIFILAMLNMYENDGIPTQQTVTNMLREYVRQIPKGRDFRHAVDEKSVEAIRNALKWELIELTNIDPPHQKAVKDTIAAGAYGNPFLNYLVRKFRNNPSKKTIVTECINAFFEIVWDKSDSMWERMVIQLLEGEHKPRALMELSVSKGCELARMAPLVTAKVEDMQLLIYTEFAANYRKREVATFIYNQQDSRKRTLPLDEVLQHLDKLTHTVTEEYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D733</accession>
    <name>A0A061D733_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768509.1">
        <property type="nucleotide sequence ID" value="XM_012913055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D733"/>
    <dbReference type="GeneID" id="24564864"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302270"/>
    <dbReference type="OrthoDB" id="361576at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="141" mass="15418" checksum="46D3BEA991A95A87" modified="2014-09-03" version="1">MGFLIHLCRFVGVVSGFVVPVIAGLYAASVGNIKQANYFLRALIFWVILDRIFSPVLFAVLGIVSRLLWPLAFSIISVALVVPRTRVLEYGDKCTVMAIKKGKQHSATNAVCATLAVLRKHVENIVMPLLGASNHNGEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7C8</accession>
    <name>A0A061D7C8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin-requiring enzyme family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768802.1">
        <property type="nucleotide sequence ID" value="XM_012913348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7C8"/>
    <dbReference type="STRING" id="5866.A0A061D7C8"/>
    <dbReference type="GeneID" id="24565157"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305190"/>
    <dbReference type="OMA" id="GTLFIVK"/>
    <dbReference type="OrthoDB" id="333572at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="185" mass="20646" checksum="681BB38CAD4CE0CE" modified="2014-09-03" version="1">MFDRITSRCVTAAVTRTRSTFQGREARRLSISPRERPGCDATRPQNIAIRASNDARSYSTGDERGYLEPRVQHLGTPLNSLDCGTLFIVKVPTIGNGVEHGKIHEWHKRRGDQVDLGELICVIETDQVRVDSMARHRYEGVCEGALTGCRYCGRDGCKVNVGGDLIIIRQDEEADEEASDEPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H2</accession>
    <name>A0A061D7H2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768118.1">
        <property type="nucleotide sequence ID" value="XM_012912664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7H2"/>
    <dbReference type="STRING" id="5866.A0A061D7H2"/>
    <dbReference type="GeneID" id="24564473"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210820"/>
    <dbReference type="OrthoDB" id="10500763at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="61979" checksum="1BFE286AC99F5336" modified="2014-09-03" version="1">MASAVGFYFDNLKDCLVFFQWLYGGAGKNKLLDVVKKLCVLLEPCYKTINEDKIRSDLLKFLFKVDAFYGKLVRKKSNNGPSIPQDESLTTPEKILDALLFCLPKFYAAIYYLWYDVNQNFKMQGGGGWKNDYPGYDGKDVFGRNWGGDLQKYLTGTSKHHNHNNVELLLGGFQEGDIKYGYNDSSGFYQGRSMLTELANLVDKESTKWNLVRDVFSTTALPTHGGSDKPNAANVLAVIDTLCETVKTERSVLALEVHEGLEKRFIDWQGLVNHCQFLRHSFGKLFKGGAFSFTGYRRASNEVKSAGFTKRAAAWLRGHLDHVMEALDGITPYRGNKYLSIFDKEKHHHMINSYYAELGDYFTKNVFPYGFTLFGDNIYTLPNDPHKTLLDDWNNEIKWLKGENGLGKLKNLLEGLKYPIGYNHGEGINVTQPNDESKHHVVTATGGPSHVTNIIEGTTNDNDQDAQSSIPKKDYRESQHEGPTDVKKTSDSATTSGVDTSDGNSEIIERNGYNDDGDDTECNHKVPDMHDGSDDACYHHMRVQRPLNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H8</accession>
    <name>A0A061D7H8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular matrix-binding protein ebh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0111320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767020.1">
        <property type="nucleotide sequence ID" value="XM_012911566.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7H8"/>
    <dbReference type="GeneID" id="24563375"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111320"/>
    <dbReference type="OMA" id="MANCISE"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160:SF19">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="2998"/>
            <end position="3022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2243"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="501"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="679"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2243"/>
            <end position="2252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="3072" mass="342598" checksum="4CD7DDF14A61F28C" modified="2014-09-03" version="1">MEYLRPATNVILQVRHCARISTLLDGLCIPFYNVVHNLERSLSFRTASEEPSACDVISRLSTIQGSAPEDSENPHKNIIHNLCASAGSLLGCRYPGTYDGSAIVYGNASRLCDAILAFLYAVFSDVYGNQPYVAGRDVLYDDVIVQLKSQLWRGHKGFRQAIHKVATGLQRYNAAVEASNKKVKEPMETVLEYVKPDGELCQGIKDLQISETSTSAEDERTVDAAVTLVERCREVARVFSKSLTAVKDAINDLNPKLKRKLENARRSFFNHVDWLSKWSKKGQKKRLDKMIQKMKSRLKQLAKAVKDRIKQEVHTVVELLKKRVREIKMKLEGITVSLEKYVNELGQCMGEAKKYIKDVKKYVNDIMQQLDGENRQAIDKAAADIDSELGKRVEELNQWIENAEAAVTVAKEKADEVHKRVDKGDKNQKIGGGLKKIEAARSQVESVSQDIQTVHGDLESWQTAAQGVLSNAAKTAGEVSKQLDPSQHGDPHPIGENLVNIETANKTISSANEQLKSQVDNLNQWITEADEIRKNAQQKAEEVYKSLTVHEQLSKKIKDIQNANKEIQNVHSGLSSVDDKLEAWKQEAANVIQGVVDRMTEVHKKLDHGDEHQPIGRGITQIKDARAKVEEVDNGLTSVNDDLQKWREAANIVLNIAVNRAKDVHKALDPTKGDANHPIGQKLNEIDTANNEIKSANEKLKTQVEALHKWIETAENIRTAAEARAKEAYDKLDVHQELSKNVKRIVDAKDRINEVHRAVETQVEELGRWKDKAEEVIGGAVEKAQYVHDRLDIGGKGTQLNRQIEGIEQANTSIQNANKTLEEHVANLGKWQTAARDVIDKADDKCDEILKRVKTDPSSKKDSIYKQSALLRDRGTKLLQAATDAKHKVESKVKDALDAVEAMDSDLKKDLFEVKKKIKEGINKVISELKVGELGEAVQKDLKQLRDRIEGLGKGLTDTNEDNPMVGSHIKILKSHKDTLGGAVNNIKTETEKKLVDSFNENIRGPLNKGVEKVTEEIGKLYEKFYPQNGSVSEADRKHLQKIFEHIKKQVSVIKGTGEKNHESGIDGIVANVRGLYDAFVEGNGKGVEARVDGWLGSILGINQNQRGTQTDGMKAVTSWINVYRQATNERDNALKAVKDQIKEALGNQIRTGQARISSGDVKDNIVQNLTKVKEACQAFVEALDAELTKDRIEKFVAPIVQKIAGSSGGRARSGVNPEHVTTAVKAALIALCSCVRQIAIEIESLAINKFGKIIDKIKPTVDGLNDKLAQATTPPSTGAASHAPGAALAVDKAIDQVREEVGKVESNFQTHVKKPVEEAVQGLDAAVTEYDNKAKHQVMKAAEGAIDEAANVINTDRDGSQIDLKSRMPNFHKAHTTITSNMQPQLEKLLNDHIGRDDTRDAKMDQVKLSRDFEKYDDHVRIGSLTDYVYGRLSLAIEKVRDEGLMEINELIGRRSGVGPTITDKQITDSFGAIKKQLEGVVESVSEKRIGYLGVSITNGSGLKTRLTGLTKALGDGKLDGAEKGLGAITTAIGNLQRDTFGPKSKTIEEAVKVVKKEVEELKKKLLNGAEPKGVSDQLTDLQNQGLGDQEYAWQPNNNGPKISGIGKIRKTIEDQNAKLPELSKEIGEAMVMVMKDIRGVLREVGMRLSHHIIPDDDLLRYLRGLKGKIGTEKAEYRNLQDITNEINGLWAKKFGKYPHKLHLATGVIRRELRKLQSDLKGDKYNGIIEPLRELKDVGLNENDWYKNLNNKGHQKIENELKSQQSMLSWQPKLIGSGVEQIANVLEEVRTALQSNDGGRKGDVINRLGALLRDAFNGSEWQNGRGKKSAGLEQIQDDLKWQNTQLSAATKKIDDATNTVMRETQDMLRKAGQKLSDELMDDDILDNLRQLQKKIGLDQSNGGSIQTFQREIGKLQEDAFTESPQQIEKAQKIIEQELANLKGELQNVVTDPLKELMEQGFGGNENWNGQKVRGFDHIKRNLQSQQSQLSNQPGQIDLGMRDITEELQSIRDALQGTADGNPQDRGVIKNLEFMTKQIGTHDDAGLKKIKSDIESLKQNHVPVITKHLNIMSSAITNASGQLGWNLGQLDNPHIDVKLKGIQDGLDNLRLTDLADAIKLCDNFLREAYEIEKNTFHALLKHVDCEVDDAIKDLTKEARGLYVDSVREALELFAKKVNEDLGDLPNDINRDRYVGYKGFMKYLQGPLSSDLTGEEQSVAELSSAFQEVFEQIEKYVAGEITRLHDEQNKERNPSLPPTEDPYTPKLKDVYDALTALLAYLRDNDGDADKLTALVERLTKALSDLVPSDFKHPSTPLLDTVSRGLSKFACEFNNTYISAYSGQRCREEHAHKYTKVLLSMIPMTYTALTNLMMKCESEWKALHISKLTADDRDNALGNYLTRCGYRVSRSGSEQDGELNMFIGGGIYELLTTPIESVDIEMLVDGEQVTYDINLVHIISLLYNTLCHYFQVCHLYVPPEPRYPCTVRDMLSWLSGLQYTQVADKLPDHCKALLNRRCHDGDIPNREDPVMANCISELPYTIAATCSHSTALLTAIQGNGHGFDLAAYPYSVDFSNNRAKLHYPADPDALFDMLRAFVCRLCRVLYFLYSQCCRSTARVKGWRECTYGRQVQSHHWQCNIMRRGSTNTTSTTTGTGTTTTSTTIHGCPPTSPLQSFLSDRCHGLLPHTLTAADGIIECANCADNLPGQQCLTPLGFWDIGFAASISGTGWDLIKRLGDMCRDADSCLFVLCRTLFHLCPIAPSSLADVFALYAQVLRKWDSHDWQEHRGGSYTDASDFISHLNTDGIDSLFPLWKELHGSYENTKLTSAIASLVGHDHKSHDALSSLCNDTTCKSPRGCAPYLQPLGLHAHHTYPQKHFGLYITWMLHLAWQFWELLSDLLQALDNIDCTASGCATCPCQPGTHGGNDTCHCPSIVQCAGPLPTLYRYGFTFRNASLLVTDNYAIRCGDLNTQLKWALHSDHFTELFRQIDQLMWHIRMPFLYCFIVLWSLVALYILHTFLYCLDVLRIRSHLLTTEASHLIDVKALLIPSRKMLSLYDASYFDDDPNELLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7L8</accession>
    <name>A0A061D7L8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0100440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765901.1">
        <property type="nucleotide sequence ID" value="XM_012910447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7L8"/>
    <dbReference type="STRING" id="5866.A0A061D7L8"/>
    <dbReference type="GeneID" id="24562256"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100440"/>
    <dbReference type="OMA" id="GDVTPCM"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF46">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT-RELATED PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="243" mass="26746" checksum="855FDC957C4B8D6B" modified="2014-09-03" version="1">MVQTLAAAFLIHGTSQCNPSLRRSGHFGAPRSTARTLYMAPIGIPKVEYRAPGSQRSDWEDIHTRLYRERILFVSQKLDDEYVNILISALLCLDNETHEKPITLYINSQGGPITAGIALFDTVKHIKSKVATINVGFCGATASLLLGSGTPGMRAALPHSRVLMHQPSGALQGSAEQLKNDAKHLLDVKKLLHSLYSRVTKQPVDKVTADLERDNFMSAEESQQYGLIDRIIQPSEKAGEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7M0</accession>
    <name>A0A061D7M0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0305950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768877.1">
        <property type="nucleotide sequence ID" value="XM_012913423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7M0"/>
    <dbReference type="GeneID" id="24565232"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305950"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="843"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="972" mass="108296" checksum="4C2ED89B2BC563BC" modified="2014-09-03" version="1">MANFSAMRAVCAVGAIWLHYVALIAAFGFDLTVTTRSLSSNAFVACHKDLQVSHNGREICPSHVGGTRYVWHPQPPSGNGNEIYTYVGENEKLRSVPLSDVVLIEGRETFLWMEYYRQQTQMVFTMGGSNRIVFTDNRFMFICGPKDLVLSEELQRQIYLFSSTKKSEIPWDAQTPLVQEIAKIGKGLGVVYMNRGRVNLPFQGCGSRPSRLFAPDNEVTVDPVTGTRSCVVNPMSQSTIGFVCEGVLEPKNCMYDLLVDGVVTRVPRPRYAEISSSYQPWVSAKYFNNLAIPSFSGECRCTDPTTGAIKAKMEIRSKNDYVCDISSMIERSLSHPIRGPWCSVVLHPGSTLTIRFPKESLGASSANEFVVDKNGQSPPDTLTQTQPGQFFETDFAPKDLTKLRQEESVYDLGIYKEVPYHSAIAGDALELDVSQMNSGEVKLIYHPDEPMTLLGGPNSFGFHWTSIHRNANIENKIRATVNVAFAFTHEYNIIGSDRGPHAVFSPKSNETNCSVTSMGNGIGDVHECKVYIDQGSRWTGIHCRPGEELLPTNCQSKGYDLTKNRIISIPESVQNETPHHIVGFQLFSYRYIDDSPVSYACSCVDQRGYEKSRLVIESYQYEKFTLTAIRTQAPHRVVPYVVLPWREVDLSTDEFAPPTSLMLYNIRRRSTTLQPGKTLAMTCGVEENPAKYGDIRCDCPRPRIDKNIPATWLPNQTEEFYYSMNETDGRIEVVKSAYADTIAASPGGFSVGYQSDKNAGKTRILVIKSILGAILISKNPTHKKYVPMTFICGKAPETSELSVMPGDASTANASAQPTSNTMALSLGYMWNVVEVKVEMTDPYRQGCGVTYGSAELFKPETPKLYNAEGQEIGCKIDLRAARKAAFYCPTPYAMDPPNCFNQVYVEDEVKNLSDVSKSLVASRTNHFVTLKFDGSQITPRDKLRQTPLLECRCVTTKGVVLSTIQIENYYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7M4</accession>
    <name>A0A061D7M4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767080.1">
        <property type="nucleotide sequence ID" value="XM_012911626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7M4"/>
    <dbReference type="GeneID" id="24563435"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200510"/>
    <dbReference type="OrthoDB" id="2192661at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="433"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="896" mass="103255" checksum="57C0A65655798865" modified="2014-09-03" version="1">MDVDEEEPEQVGPVRESNNSIAPGTASEVALTETAALPRAPEGHAPQAERAGNTPRMPPHYARLNAKLQFLHCVMRQIDGPWCHWVPDVYKAVVTKYQRMPRGGWKVLAEYANEHFEFHKTHKEVEQMARQVVAKAARSQPTDVGEIASLHDVDSYNALQEDFDRIMAQRLREPGVIRTVKNKRHTMDSLDFTAIRSLDLVVHNYVKHNPVTDMGMLAILYQTAQDCYDKYSAKPSSSSGKKEAAERRIKELEEIGALLLKYKQKVPLEKEDRKRVYRQMDKYNMIADKPQELSYVISRTQEELQKEQDKLKNAKFKQELYNHNRMFELYTGHFYRTLENQQDADESAINEGMMIEYWAQMWVKPNAPHNGEGYLVERPPAENMAGFPTYEEFVTIVKKLRDWKSPGADGIYNYYIKWLTSLHRVIYRLVEEACQQGKVQDDWFYCGITYLLPKNKKPKSAAQYRPITCMSNLYKLTTRCATETLKREVDGRGLRSENQMGTRSNVQGAKEHALANIALNEKHKGKLLATWVDVMKAYDSIDHAYLARVIDNLNLPGWLSNFIKQTTKRWNIEIRWNKNTIMHKKVERGILQGDSLSPLLFVLCLDPLSRHLTRIFPKVELSVPGGRIFATNHFLYIDDLKFFAHEESTMRGMGREVEKFFNDIGLRINRDKSATNTEACASIAKQMEGPETYKYLGVTETSNSLTSDGMFDIILQEICRRTELLAASKLSGKNLSMAINQYALSVINYYIGVIPMDITHFDKIDLEIGITNQDNLVDTEKFKKQKYEDLIEDLKARQFNQQTKIRVIPYVMTWEGIVTKEHSKYRRDLGISDRMEAHIQRVVIQETHKIVMRDMKPKEDYDSVEDPQAQTGWMPAWMAPVTSGNGPAWIPQPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R3</accession>
    <name>A0A061D7R3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose inhibited division protein A family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0304860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768769.1">
        <property type="nucleotide sequence ID" value="XM_012913315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7R3"/>
    <dbReference type="STRING" id="5866.A0A061D7R3"/>
    <dbReference type="GeneID" id="24565124"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304860"/>
    <dbReference type="OMA" id="IAMMSCN"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600127" evidence="5">
        <location>
            <begin position="19"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="611"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="690" mass="75154" checksum="D39CA7A2E7F8F918" modified="2014-09-03" version="1">MLLLSWALAALIGPRCGAIRQLRPRPPAFSVPDVVVVGGGHAGCESAAAAARVGAKTVLVTPRTASIGEMSCNPSIGGIGKGNIVCEIDALDGVMGVAADEGAVMYHLLNSSRGPAVRGPRAQEDRDHYAAAVRDIIGKQDGLHVEESMVEDVLVEDGAVRGVVFADGRTVQCKAVVITTGTFLRGRCHRSKTQVPGGRLDRLKGEFEAPADGLCATLARLGISTNRFKTGTPPRVKRSSINYDVLEVQNSDLDPTPFSYLNAESGPPLRDGVVVIEFRIVREHLGVLPDYESGFGKGLGPRYCPSLPAKITRFPNVAGHVVWLEPEGTDSDLVYPNGLSGAFPPEVQLELLRTIPGLEEVEIVTPGYDVEYDYIDARLLRHTLQFKQIEGLYFAGQICGTTGYEEAAGLGLVAGCNAALFALASGREFVLDRSEGYIGVLIDDLVRKGTSEPYRMFTSRAEDRLFLRIDNGDIRMLKKGRQCGLIRNAERVDTIREKYIRAQAVINRLRSVTLPLNKWDVNMDGADCKNGWEMLKVSGVTLPSIEARVNEHYPDGRVSKTELPPMSEAERSGIDAAFEGLEDGISEQAARRSAERTTSNKYLQSVVEAQCKYAPFVDRQAKQMERTLRGRSVPLRPDIEYTRERFAFLSTEEVEVLNRHRPATIAEAANLQGVTPASLTLLAEQVIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S3</accession>
    <name>A0A061D7S3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0304960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768779.1">
        <property type="nucleotide sequence ID" value="XM_012913325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7S3"/>
    <dbReference type="STRING" id="5866.A0A061D7S3"/>
    <dbReference type="GeneID" id="24565134"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304960"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="336" mass="37788" checksum="6488F406CB93868F" modified="2014-09-03" version="1">MKKNAPWVEKYRPAKLADVVFQTHAVATMQQIVETFNMPHMIFHGPPGTGKTSAALAMARQIYGVEGMKERVLELNASDERGISVVRERIKTYTRLNISNNRINPETGRVMPNFKIIILDEADMITPDAQAALRRVIENFSNISRFILICNYLHKIIGPIYSRCSAFHFKPIVQEAQVERLRFICQSEQLECDDAALDFLTRVSQGDMRRSVTLLQSTASLYSKVTEDAVRNVSGYPPRHIVEDIFTACMAPTNEVEAICKQIVHDGWEIAAIFQQLAEYVVNCETLSDVQKAMITIELSGRDFALLQGGLQYFQLASICFHIRSVIANGGQRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D837</accession>
    <name>A0A061D837_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0307300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769012.1">
        <property type="nucleotide sequence ID" value="XM_012913558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D837"/>
    <dbReference type="STRING" id="5866.A0A061D837"/>
    <dbReference type="GeneID" id="24565367"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307300"/>
    <dbReference type="OMA" id="IKFMMRA"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR96826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="374" mass="41802" checksum="D39D31052A62B8CC" modified="2014-09-03" version="1">MDEELKIVDVWSDNLEDAFERIRDVLEHYPYVSIDTEFPGIVAKPTSYQEDYNYQTVKCNVDLLKIIQLGLTFADADGQTPSGVSTWQFNFKFDLQRDMYAYDSIELLKESGIDFEKHLRKGIDVAHFGELIIASGLVMNEDVVWVSFHGSYDFAYVLKLLTCTSLPANQSEFFDLLHDFFPSLYDIKFLLDERSIKLSGRSSLQRISEHLDVKRIGPQHQAGSDSLVTCRTFFKLMQRYFENELDDEKYQGVIYGLGKASAQLHGDCKSDGLYNTPTYAMALPYANGPNSMKWGSDMQAHHVQTTLNPGIVNANLHGSSGAVILNSSVSSPHGEVTSPLGSNVLPGSAAMVNNGAMSNMTGLSFYDTPQFTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8A0</accession>
    <name>A0A061D8A0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PCI domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767330.1">
        <property type="nucleotide sequence ID" value="XM_012911876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8A0"/>
    <dbReference type="STRING" id="5866.A0A061D8A0"/>
    <dbReference type="GeneID" id="24563685"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203010"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="181"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="395" mass="44432" checksum="9A6BC3F51C4E1F19" modified="2014-09-03" version="1">MKGDADATLSTVASNHPNLVPLVEQIRDDLAAKHYHELTEALTSLLASDSLVCDDKIRVFEALVHPIKDALNTLRFAQLLAACSENLDPKVALEHLCKYDAFLEKDFEANVMHQIAKVTVKTIGAFIWLQAHHMVKNGQIKECDALLSDVRQKVEETMNVDITVHSAYYRAAAEMNKAAKNFSQCYKDWIMYLAYTSTNDIPEGDRVAIAVEITVCAIVAHDSFGFGELIHQPIIEAYLKGGDHQWLYDMLIIFNEGQLHLFDEALERHRGKIVHTELAGRETQLRQKLTLIALLNLALAKPNKQRCLTFQEIADHCTIRIEQVEPFVLKALALQLIKGHIDQLQQTVSIKWLQPRILDMGKLQGVAKRLESWIESTNNIVSNLEALNKPANATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8A8</accession>
    <name>A0A061D8A8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0306620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768944.1">
        <property type="nucleotide sequence ID" value="XM_012913490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8A8"/>
    <dbReference type="GeneID" id="24565299"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306620"/>
    <dbReference type="OMA" id="MIGRIYC"/>
    <dbReference type="OrthoDB" id="365912at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010742">
        <property type="entry name" value="RCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906:SF0">
        <property type="entry name" value="GEL COMPLEX SUBUNIT OPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906">
        <property type="entry name" value="PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11784" checksum="E4DD6AA97A345671" modified="2014-09-03" version="1">MSLSSKQSKATTSSVEPSKLSCSNALWRVKCSVSLLTGFVLGVIPVRGIFGFLAFGLAQGIAGLLFLTFMKLPDYVLDHMEALTEHVMMSFSCFTVTWIITYSLFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8C7</accession>
    <name>A0A061D8C7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger (B box) protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0203260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767355.1">
        <property type="nucleotide sequence ID" value="XM_012911901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8C7"/>
    <dbReference type="STRING" id="5866.A0A061D8C7"/>
    <dbReference type="GeneID" id="24563710"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203260"/>
    <dbReference type="OMA" id="FRDSEEW"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717:SF45">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="255"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="303"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="507" mass="57435" checksum="A8DCE7ED27A8720B" modified="2014-09-03" version="1">MENPVVRDSDEWNALEFALQLRCRSSRVTLLQAWNVTKPDAVSVFSRWVQTTPIVEAFIDAGGLDRNNSTQDVCTRGFEVGSNGFKVSIGNIHCASFPLLRSTLRDGATSDTRSGALDDKGQILPPKNATTTNIMYGDRKVYEYFVCDVALGKAIAAADEVEAQRLRLTMPVEYDSIYLENHGRERFLDVTAMLKPREPAAAPDNRPEEFFSEGVLPQFAFRREYIIYGASQILPRYLIQFEFDPAADETFALPLCDSCQNDAATIYCPSDTARICKKCDEKLHTQNKVVSRHIRVPLNQMPRPAARCRLHPSKVYTMYCTFCHLPVCQHCASGHIHGQGANEANSARFVPIANAYDAAIYEMQQQSNNAISRRREYLKSLLQQVDRIEQAVEDNCERVEASCYENLEATLKQLHSKIGGSLEELVAEQTENKRQMSEIEWSEHFADYLKNTLLPADYLRAWLRHCRVRSDMDADAYKGPLQEIFPDLDMKGELAITHEHAAEHVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I4</accession>
    <name>A0A061D8I4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768999.1">
        <property type="nucleotide sequence ID" value="XM_012913545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I4"/>
    <dbReference type="GeneID" id="24565354"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="264" mass="29134" checksum="021D5689F220DE5C" modified="2014-09-03" version="1">MAGRGTEFQLDGKKCQCVVISCQNGTELCTSSTCTTCMACCSPKCEGCEKKCRDGEKCKCLNLCCGCPTNCYENGFDKASCKEKNQTKGCKRCLTKCTKSNRCICYQCSCGTQCNGFLCACCYWCNPGKCKRKGTCDGFVLGKCPEGKCKGHGTYNGEGKPVYVDKCECEPNKPCKCIINQKEQNERDKSDTKCRCIRGEPDGHGNCLIKCDLCGQLCSQDSYIHQGTLVVVPLAIAMVLIIVWVKYRDKFRKAFYELRGTCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K6</accession>
    <name>A0A061D8K6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769034.1">
        <property type="nucleotide sequence ID" value="XM_012913580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8K6"/>
    <dbReference type="GeneID" id="24565389"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307520"/>
    <dbReference type="OMA" id="HATPIHE"/>
    <dbReference type="OrthoDB" id="10407285at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="775" mass="85185" checksum="96A7E4C9AC24EBFF" modified="2014-09-03" version="1">MLRSSDRRAGVVWQEDPSRYPRHMGEFSDGRSHQYQVPCGNGEDRPPPGMAGMRSPGRPTMEDRYTQPPIRPNRHIRGSDRYVVYPSPSPQPQHNAFAGLDPGRPPAYDQGWQRGAVPRQSRGRHEYRDREAVQPSAQHYPSAIARETESYDGDNRTSDSVDLLDLRLQTHKLRRHLMEMKQTARALQQNMPYADRSFDDAVPHPPRAPPQRGVKAPTKRRDAASTPKDCSEPWTEAASHLVSGLGSMVLAVCQLVSCTGKSALSTCTALSQGADAIYNPRAIRPREPLPHNGSERRVSPNYNRHYPRPRSRHHGQFQERPFDGGPRHPGRAEVPSYSGPRHDHSGRWEPPYEPDAPRDTRRTRTTNTALRRMLSPSDPGDYSDAEVEFSEGASSYGYTSICLSDNNAPPYASETASSVVLQEDAAAAPPPRFRDYPYFDGSTSSRDNMIWRNPSRPWARPPDVFYGGVGDVMQEPPAGYPPTFSKEAAREPVRKINLGDLDYTEPPLPRVSPGPDLLPSGYDRLPRSSPLPNAQPSTASQMPEPHPLLRPSVIVARPAECLVEPRSPLRQQEAAPPANEPTGTNVRRLDVATDLPRRTPSPIARRPGVAEAPSTGNLLTPQGGGATVGTVANEVSRPEADDRSAAPSSALRYDPDELPLETNKYAPNPTMTAEERWLQSVRTLAEAEATYQGVLGLSKNAGGSDHTQSAANQADDEHSDGGGDLAEVLRGPPQAAPADLKIVKVGSHTNAEDAVKPDKRCTAFFKKIFNQRKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L8</accession>
    <name>A0A061D8L8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768478.1">
        <property type="nucleotide sequence ID" value="XM_012913024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L8"/>
    <dbReference type="STRING" id="5866.A0A061D8L8"/>
    <dbReference type="GeneID" id="24564833"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301960"/>
    <dbReference type="OMA" id="YIVENIY"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="277" mass="31938" checksum="48ECA868AA43DAD4" modified="2014-09-03" version="1">MGLVFPIRFSLRRLSGGAAKPHWGEPPKNRWQPFLPDRHHYGEHATYNGFVLLLRGLRPRIERACCATFKTVSDVASLLYRPLARSVLKHNPDIRYQLVALVSFFGTTRAITKYYSDMYQGIVDLTSLLQLGVADDLNEQGFWNSAKEDRDERIKYFEKEQNRLNKLWENAFKRAVVTQSFDALCEDVIPRSDDVNTGVLPQVSWRFNMIPYGRDNEDAVVFDTPAHDAPLRAMALNFTYNNLSGDWGDYINRQDNKNALLRPARQMFTDIYIPGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S1</accession>
    <name>A0A061D8S1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769124.1">
        <property type="nucleotide sequence ID" value="XM_012913670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8S1"/>
    <dbReference type="GeneID" id="24565479"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308420"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="138" mass="15355" checksum="FDCB4321CA7D681B" modified="2014-09-03" version="1">MEVANAVTSVVKDVLVPVTAQHVSREAPPIPVTMRTVISYVTKIVMDHVAKLNVHAVQPLSPFPVASSFPSSLLSSYSIYAYFPFCLLPKSAHISSANCRFASHFITKSDTSYYRNIARYYKMKPHCSNNIVLFNVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D934</accession>
    <name>A0A061D934_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0105440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766421.1">
        <property type="nucleotide sequence ID" value="XM_012910967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D934"/>
    <dbReference type="STRING" id="5866.A0A061D934"/>
    <dbReference type="GeneID" id="24562776"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105440"/>
    <dbReference type="OMA" id="YFGWARQ"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000007">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="307" mass="33174" checksum="FE044FFC287C0F5C" modified="2014-09-03" version="1">MKRPLIFTGNWNKQLVNDICTLAGTPLGKANVSTFSDGEINVDLQEQLHGANVVFIQSTSPPANNLLELLFMIAAASRSGAKHITAIIPYFGYSRHDRKTSNGSNISASDVARMLELVGVNRVISFDLHSAMCQGFFGPRVQVDNINVHRLFLEHLSGLEKVAIVSADAGAYSRSVHFLNMLANAYPSYDISSAMIFKQRLTANQVADAKLCGTVEGRTAIIVDDIVDTAGTLCKAAELLIANGAASVFAVITHGIFSGSALHKIRSSCIKRIITTDSIRHNETILREPKIQIVSLCPEIANIIANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D942</accession>
    <name>A0A061D942_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768683.1">
        <property type="nucleotide sequence ID" value="XM_012913229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D942"/>
    <dbReference type="GeneID" id="24565038"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304010"/>
    <dbReference type="OMA" id="WESMDAN"/>
    <dbReference type="OrthoDB" id="363827at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="25279" checksum="E72FB0205BA0418F" modified="2014-09-03" version="1">MSRLPPRRPDAPSFYGEWRVVDEHEFMSPTVADVRTESEYSQAVDEGGLLQKELHDLRSTLTSPQNDFTNRLEEINRETAGRSKQFVYGAHVVLEQLDRARQKFLAIETTWRKNNFQRYLDDELLNSGQHLSHVDRKLAQAVREVVEMKRDAETALIELTKSVASVDSLIGKTNRLNRSSRAFMQKANAEKNATSLSLKAQLFIAALLSFAGYTLMKYLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D946</accession>
    <name>A0A061D946_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766431.1">
        <property type="nucleotide sequence ID" value="XM_012910977.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D946"/>
    <dbReference type="GeneID" id="24562786"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105540"/>
    <dbReference type="OrthoDB" id="361661at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lysine-specific demethylase-like" evidence="3">
        <location>
            <begin position="171"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1525" mass="170561" checksum="9E855342C9CB9C6B" modified="2014-09-03" version="1">MDSDSAVKLPPIYVHKGKKVRTDVLTRQALVPPIFRRRESLKREARYSKVHSSDTSGEIQASANEAYCNALYLRYQTDFNYLSPELVLNKKVSGNTNIKSVGTETNKEIVSHLSNGKRRRTKSASSDSPDSVPTSPWLNRMLPILLKVMSGRDGDSNDISSIGFKEEVLQLYKTGQKFEECNLRDVATVLSSIVSYIDDWRASAQIAISQRITIEEARGLMEEFQELSGGLVRVDLATEIDNDIKICEAFGAKVRLTMTTLSSSNDRTVSLEEVESLVQESSSCRFLVPEVVALQSIFRNLISLRSLMETSVLDLDLSECESLVSICEKGLVRLPRLDELRRRLQESVWLHTASKACQRQVRYSLAKSLIDNVPDVLRDHRLYVILKKKCHDVEQWMERISKFSFYQMVSNEVTYSGLLSKKDVSSQSPVGSGSVVGVKCDARTFEEICSAYHQLELTLPIFRSIEPLCQSLKRLQRRLHKIEVVLQTNSRNPSVATDCLLLLQHAEPLSEIIDLTEYLEPIRSGVELWLNYEKRCRKVLDSVKAFVLSKDFNKLKSDWGFLLNFRKTTKLSDADFIGIADLIRLYEQEDRVPFEDVRQLEAEFRSLRIKNLVLQREISEIYEKGVTLNSKVDSAFDSVKEDVSKSGSVLSHVVLVILEVLKFGAKLDSMPKLRLCLSYLRWSREFYTVFFSTTAMLDGGSRLRTLAAEGADDRFNEITSHAGLHESITNQLNKIGCLSIGNEAPRTESQLLIMPTIEMLSFSSQVYNIDVSFFVELRRRIIDDFRCLRSELQIHAFAAVDGALWLDKGSFDNVCCRFKDCSLSFSSTATRYGVERAQLLSRRTAKAHKSPSCDCARVPGTLITLPTLSEFRAIDLQSQVERACGTLVTDDGGLRILGVRIDDGLWRSCGGFSGIGNLRRLVIIIYMDIKACVCYYAISSPAANPAGNYSISSCAVLNASGRFVVLKGTPPKQLMLDDVSTLTHSFCASPVPYGFFAFGRCDGKLVVSNMSNVHVVDEFTIELEGTACSSNDVTFCGFGNLSPVGSLPRHWCSAMLALCHLLKLYGKKMRFMLIDISTSTRSIIRDRCSLAVIYEVVIGGSVKSGGKINFSYGYHIASDNRLNDRNLHENAYNFSDRIDSYSRHRIDAELHLQMMKWKVIPQLNPDNITMTNICVIGAGALGCHIIRQFLAWGARNFVVIDYAKVTNATRQCLFNSRDSIDQAYKATLACQEIKRIRPDADAIPVNMFVPMPGMFFGLSSQIHHLVGHFIYEEDLRASYTTLTNIMLKCDVVFLATDSKESRWLPSLIGAAHRFHSAEVNSGVLDEANPNGELRENRRGPLVISTGLTFDTFMVIRHGYGGFYGGCYFCSDVQWPEDSISSRPVDETCTLVKPGSVAMCAAAAVELFISLTQHPRRFEAPHNGTSCIGGVPHAMHMSLSGKAITREALQSADMHVDQFYVEASKRCVCCSDAVIKKLKSNAFDFLHQVVRTPSILGEISGLNRTLSAVAGYDMNTTAIEDDFVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D960</accession>
    <name>A0A061D960_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768703.1">
        <property type="nucleotide sequence ID" value="XM_012913249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D960"/>
    <dbReference type="GeneID" id="24565058"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304210"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="11050" checksum="1433AA75058C75C4" modified="2014-09-03" version="1">MHAGSGTDGFSALGDPGSHLPQHNKDSLVYLRAFDFISSKTRTPPTICAKCTAKHIFLCVFIGIVCLFFFLIILFNLGVVEWHTNAISNLFQKLSKPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9B2</accession>
    <name>A0A061D9B2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768763.1">
        <property type="nucleotide sequence ID" value="XM_012913309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9B2"/>
    <dbReference type="GeneID" id="24565118"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304800"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="104" mass="11584" checksum="3BAF8CA898C455F1" modified="2014-09-03" version="1">MHKPQSVGQYENDGNDDGVGRGEIIPHPVERPDAEVDHDADDDDDEGDGGDDVREDVVDRCAALHGVERGMQDLGRYWRKKTALDGTDTLFYYTLHSNVGNRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9G0</accession>
    <name>A0A061D9G0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766531.1">
        <property type="nucleotide sequence ID" value="XM_012911077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9G0"/>
    <dbReference type="GeneID" id="24562886"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106540"/>
    <dbReference type="OMA" id="DTMRIEK"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="748" mass="84965" checksum="CA87283E8E5B40DE" modified="2014-09-03" version="1">MQHLFDYSLEQRFADITDAIRHGNCEECKRSKIRRLEARVSKFICAKRECDAKMNDGYGVCDSVALESYPFGRKHRQNVRLESMKNSEDVDKIQGSGATEAVGYDRISNKRQFDVATYVSKLGRDDLRLFKSQLSESSRKKKRRITPMASADEFATPDVDLSTLRAHKRCSRKPSVRVDEVKPRTDKHRKSVKALNTSEVEAQVVKKTLHKLDNKAADSAVKLPPSEPTTSVETSVTTKANESGATGIVFDVTQATAPVPNTPLPPPSPTKDARKVDSTDIFGASTLEKLNFSMPVGNPLFAPKAIDASQFSVPKAPPMFVFGVQPSQMSDSSAPLAPAPQPPIQTAQAPLAMPPPVAQFNIPGFSAVQLDNQAASVPNAFAATSFPKAKRGGMRYRGFFKRAEMREKPRRKTGPFENPVKRLVRLREKERVFSQVPLERKIPVVKPVTSQLLKGVEGVPQVSTEVLERRLEFLLSPKAVDQQLSAKLRPGLTPYLAELYMWERQMRDLRRIYRAQYLKTLASVTDAERYRQYQQYLDTSQENRNKAEMRRRAIYARVKERAVLRDTMRIEKRVSQAIQLERLSRRKMANVYFLHKLQRGFDRGDDPDPSTSPNERDVSVVDLAKHLGHPVEDASNVKRQIKTGRHFFREILKESFELMPEDSDRYEIHTDNSQSPSERAAVAYRFFTDDEKLRLLETKIAMLNEKIDRDSQLHGKSKDNLYIQIRDHLDAARVAHMESNQLRKLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9H0</accession>
    <name>A0A061D9H0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766546.1">
        <property type="nucleotide sequence ID" value="XM_012911092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9H0"/>
    <dbReference type="STRING" id="5866.A0A061D9H0"/>
    <dbReference type="GeneID" id="24562901"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106690"/>
    <dbReference type="OMA" id="TFECTID"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="281" mass="30386" checksum="F81EBF4FC0465127" modified="2014-09-03" version="1">MMPGLRQDGGREQHNPRRQGRFRVSHNPDDVYDPMFPNEYDHVSNEEAQRACQPASRVELKFANVEVEKLSADEAHARRLKLLEEADRGGSSEAPPKPAAQGPKDIGLRIMQKLGWTEGRGLGAKEQGIVAPLVGKNVGKHVGVIVQAAAPTIKRATRGPTKPNAARASESDPNDGDAASANEGATSTHGKASTSRILKLDGAECPKSAEEVQGDFEESMCPFGTLMNVLVRSSGVGLPFTVYCEFEDHRQAVEAGKNLRQSIRGYNVVPSFITDDEYAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9W7</accession>
    <name>A0A061D9W7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0208630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767895.1">
        <property type="nucleotide sequence ID" value="XM_012912441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9W7"/>
    <dbReference type="GeneID" id="24564250"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208630"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59055" checksum="59E9F398B4FEA33A" modified="2014-09-03" version="1">MSGGTAAQPGGADAPDADGKTKVEKIKADYGPFGQVLYHVVSFTEGYEQQVLYLCMRVFESTMSFTKSQLTTLMTVSILSRLCFSLVWGLLADAFETNLVMAAGLLFMGIASILLSATSRFSSQKIISDEDDDQEGGSSSAFTRIHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYLWISVGIAIVFAMHTEKVLTTPYNSMKDFIGQISGAFTAVFSNWSSFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDLKVGIAILVTTIGGAAGTAAGGIVIEQITKLHSEYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAILGATLVTVGGVDRPIMRKVIPDKYQASASAIIQCISGISVSVSFVEIFAYVSEKLHGYAPSTQAIDDMDAALKDNNTEALRKSTMYMIVIGSLLNIACYGALFGTYQTDKEQVKEENVPVRVERNERQEKREEMKRQLSAATHAEKAVTPQEVEARSTKTESPIEELPSSDLEVEIPFEGENIADRGTPLSDEAIKEFIRTGGKSTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA26</accession>
    <name>A0A061DA26_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766786.1">
        <property type="nucleotide sequence ID" value="XM_012911332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA26"/>
    <dbReference type="STRING" id="5866.A0A061DA26"/>
    <dbReference type="GeneID" id="24563141"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108980"/>
    <dbReference type="OrthoDB" id="10463301at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="210" mass="23776" checksum="73F02DBB9BC60112" modified="2014-09-03" version="1">MLFWLVGFNTYGLIAKIEGHIEGLLMEINFDGNHPMSTGIYPPCPHLIADTLTETSLYAASVIYKLRHINSKDAFSNFNFKYEYRKLHYSPDPAGLLCQLRDYTYACHHQLAFLKSQCNRDKLSGGWKHHHYGSDITASNSPLQAFLTDGWDSDFETHLFDPCNLCLKSRTRMGFTRGDLPRISQQGSVISSILTPSCGGENDYSLRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA28</accession>
    <name>A0A061DA28_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769762.1">
        <property type="nucleotide sequence ID" value="XM_012914308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA28"/>
    <dbReference type="GeneID" id="24566117"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400680"/>
    <dbReference type="OMA" id="LEIHYKI"/>
    <dbReference type="OrthoDB" id="363848at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595605" evidence="1">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27764" checksum="E74F879935530B0B" modified="2014-09-03" version="1">MRFCSTSMFGCFLNLSILLVACPISYSRKVWPSGGYTLATLGNNGVHEHTFRRRWTLSSNIQTDVEAKLRLELVRLAAQLPNSSNLPLHNAAFLQKEATRIRELIVPDSYQVYLNKYYAVKRIQHRGFLGDFIAFVFGVEEVITFSAWQYRPNILYKGGNLTLEIHYKIPIREKGIKDLFFEPIVVYTCDVTPGKYVEGAAVFKPGSVEILTHPFIPWKRISAGTVEISAPRQPTIFSPHMTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA73</accession>
    <name>A0A061DA73_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769043.1">
        <property type="nucleotide sequence ID" value="XM_012913589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA73"/>
    <dbReference type="GeneID" id="24565398"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307610"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="156" mass="17165" checksum="8AE0687B424D618E" modified="2014-09-03" version="1">MMRSRSKEADATELDMQASSISVRVAWEHLYTDTMLCAALTSPSHATCLWRCTRFVGASGPQSHGTDGLRGPRTAGFYADTPAHTRRAADPAGRSRTTPPRRYTHGPSPGQTPTQPLSTGSKRFESPLHSEILVTKRSRRLATECANRRSGLQRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA9</accession>
    <name>A0A061DAA9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein 60, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769832.1">
        <property type="nucleotide sequence ID" value="XM_012914378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA9"/>
    <dbReference type="STRING" id="5866.A0A061DAA9"/>
    <dbReference type="GeneID" id="24566187"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401380"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="557" mass="59789" checksum="50C9E4226289BABD" modified="2014-09-03" version="1">MVNRGQLARSVFHAQRRFFAKEVKHSVECRQGLLSGVNRLVDAVSVTLGPKGRNVVIAQPYGAPKITKDGVTVAKAIEFSDKLENLGAQLVRQVSSNTNDKAGDGTTTAAVLARAIFQRGCRAVDAGLNPMDLLRGINMAVECVVKYLDSIKKEVTTSDEILNVATISANGDRVVGQLITDAMEKVGKEGTITVVEGKTLQHELEVVEGMKWDKGYISPHFVTSVKDMKVEFDNPYIFLSNEKISNVKQILPVLEHVLQQQAPLLIVSEDVDGEALAVLIVNKLRLGLKVCAVKPPGFGEHRKATMEDLAAMTGAVLAGENNFTVDGDLVGTLGRAKSATVTREHTILVEGLGQKKDVEERCDGIRAMLKVCDSTYESDKLKERLARLTGGVAIIRVGGASEVEVGETRDRVDDALCATKAAVEGGIVPGGGSALLHGSKRLADLQTKNYDQKVGVDIVREAVQAPVKQIAQNAGFEGSVVAERLLQSNDVTHGFNAQMGEYCDLVAAGIIDPTKVVRTALTDAASVASLMTTSEVAIFDARKDKEANDEGMQQPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG2</accession>
    <name>A0A061DAG2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766901.1">
        <property type="nucleotide sequence ID" value="XM_012911447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG2"/>
    <dbReference type="GeneID" id="24563256"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110130"/>
    <dbReference type="OrthoDB" id="365257at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595954" evidence="1">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="149" mass="16830" checksum="629EFD84E398CD62" modified="2014-09-03" version="1">MWAPVIAALLLCSTWLPSAHAVTAHKEQDRGDDNHPDRMKYAGPILTSMCTTTSIGTTGTGYSTISRIRTSDFMRRQDGMLIDARASLFQRALYNTTHPRNVKGFTKQPPDLHDRLHSIHDGYYSPIPAADFININEPYYYELLAEQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI3</accession>
    <name>A0A061DAI3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP1/OBG containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768090.1">
        <property type="nucleotide sequence ID" value="XM_012912636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI3"/>
    <dbReference type="STRING" id="5866.A0A061DAI3"/>
    <dbReference type="GeneID" id="24564445"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210570"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="1">
        <location>
            <begin position="117"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="231" mass="24433" checksum="3858E5FE71AD6E0F" modified="2014-09-03" version="1">MSLVDSPGLKIKSSFISSEPICIASGNTADAYRRSNTSAAYYKGIPYTLGCKKAGALFVLGSDTNSDELALTHKEQFDEDDGNVAAYSDNAAICNAELPEAPTFIDATDTANDWHETQLVDKCRILAVGGRGGDGCVSFRREKHVPLGGADGGNGGPGGSVYLICNEAMSNLNPVKQFYIYKAESGHHGLGGRRNGAKGNHRFIPVPPGTHVYSTSGELYAVLQNEGKTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM1</accession>
    <name>A0A061DAM1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor SUI1 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769218.1">
        <property type="nucleotide sequence ID" value="XM_012913764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAM1"/>
    <dbReference type="STRING" id="5866.A0A061DAM1"/>
    <dbReference type="GeneID" id="24565573"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309350"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="180" mass="19849" checksum="D460309C1E7C478D" modified="2014-09-03" version="1">MVKDKAPEECVSEDEVPALAAVEVEYCPRCGMPFDFCDFGDKWESGECREECARRYPEIFGSAEDVAEQLSKIAVAPPAAPRKKKPEVRQEVTVQRSTRSKRKVVTSVTGLHLFGVKLEAAAKLFAKQFASGAGVVKGVPGQMDKIDCQGDVEDQVIDLILSQYPEITEDKIVRLTAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAQ3</accession>
    <name>A0A061DAQ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769253.1">
        <property type="nucleotide sequence ID" value="XM_012913799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAQ3"/>
    <dbReference type="GeneID" id="24565608"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309700"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="101" mass="11235" checksum="7F73F0C4BEF9382B" modified="2014-09-03" version="1">MLASNIDGVGGTLERLLKVNVQVRETNDYVESDSKGFEVPSVGGDAKLALTNTAHYFTRLEYKKLIWRCLSKFNGFKGGFNEMRSHMLPCKYQSVGDGKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAT5</accession>
    <name>A0A061DAT5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-disulfide reductase</fullName>
            <ecNumber evidence="1">1.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0111030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766991.1">
        <property type="nucleotide sequence ID" value="XM_012911537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAT5"/>
    <dbReference type="STRING" id="5866.A0A061DAT5"/>
    <dbReference type="GeneID" id="24563346"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111030"/>
    <dbReference type="OMA" id="WARRESH"/>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052259">
        <property type="entry name" value="Nucleoredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871:SF96">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="7">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="166" mass="18720" checksum="47DB3A3498D9508F" modified="2014-09-03" version="1">MASGSDSGAFLGHGSLKNQRGDTVSAQELHGKSVGLLFCDGNNPRCRSITPFLIQFYNSVNGPGTAPKIEIVYVSCDATREAFDNNVRRMPWLHLDYDDSLLPVLRHRYNVIECDSEYGNFNSVEIPSIIVVNSHGSEIQRFPLYHGREQSAQALRRWDWRNCLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAY7</accession>
    <name>A0A061DAY7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0212260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768270.1">
        <property type="nucleotide sequence ID" value="XM_012912816.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAY7"/>
    <dbReference type="GeneID" id="24564625"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212260"/>
    <dbReference type="OMA" id="RWEGQSM"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="3003"/>
            <end position="3026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2115"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2207"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2263"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="946"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1186"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1524"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1665"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1701"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1753"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1776"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1791"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1902"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1945"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1971"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2046"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2120"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2210"/>
            <end position="2220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3078" mass="326305" checksum="662EB5D02A92910D" modified="2014-09-03" version="1">MVHFVQLKTLKQCFAFLLRLHERKGIHDIVHTRLLDDFASNYKNLNRQECQQGFYSFLGKVKAFYQKLTTVNVSKDVVDIGFMSPSDILDALFECIPRFLAAVYYLLYHVDSTYNGFGGGSWGDLYPGYISYSGYRWGGELDTYLTAPSSKKDYGVLPGGFEINDLTSNYRYGYSQGKNMIKDLRAILEKSNNLCKFFRDVIFMVLNRYWQDVNAANVIGLVSVFCNIVQMEKGNKNNEIHNALQKLPKEGNNCCIDWNKLQQVCGELKSAYEGILGSGFDITGVVPKLGDLQNAKFATRFATWYRDDYTGAWQTIKKIKAEISSNVSFTPKQIADKFLFRNGFCLGDQKLKGASNDFVIAQWAIFIEKLVDDENGLEKLKKVLDGTVCASHAARPASSPKVVGQPSDSRPLTSQPNHVSLAPSHAPPQAVRSSKVSHEQQGSRSVKRPNGAPAAEVPEPKILPANKTPENNLLGKGGIRRNAAQGLTSQSPVPGGKAQDSQGGVTSGKHRQLPEIIGKHPAARAESPKSKPPVNPAISPSVRSGSLGPQYKQQPTSRGSHDQISNKPAKPQITVTEQHKTASGPSALPHTPASVRAPGSDDTPVGPVKDSSGHKSLSPDSGGPSATGRSQSSSGRNVDRPSYDADGSSGSRGKKGSHSAEASPSNIAASQGIAPPVRKAGSTSHPGKSKDSHVSGVPASTSTTKNVIGSQESHKTTPVSKSDSPSVVATVDLLGGGSNGKSQAKAGKAADEAGAKPPSAAPKEARQEKVHTSPAQTQHRSFEKGGSVPQPGPSKRTTLPKNSTSESLQHGQARDVPLQNVRPNTEQPQARGTPAHSSPHLPKDPISASEPHDMGAYSTSAKQLGSKSAVSHDTVSAPGQTVSSTVSSPSGGSGQKGDMHAGSKALPVPDKPSNHRAATNSGDDRSKIFAVKASSPGASAGVRGNVHSQDSANVNSKSVTTRSAGHPSTSGTKHLNSLPLNETNNRSQVSHDQAGSSNSLQPVRVPATVTKPRQHEHVDSSVSRQDTESGVSGGDGEHGKPSRSRSPEKRSAKNKDQQVDTSTRTDTGAKSTTAPTAQLPLSDGGLVRDERVNFHAYDRRTLPIVTTPSDGVETTTTRSPSRPSAAPRGSGSNVGGVDSGGKAKVVSALAPQTHADIGSTDHVGHISSSQVHTGPPKDSIAQGKASLPSGSPTSLLGVSAESEPTKAASISSPDSSAVISSAKGVPNTVNTVSVTSRSDQDGSTVKGGKSGPSASASRSKSSDSSRDNHRVVQALSSARTPITTGDSSNASSHVIQPVSASRQASGGAGLNVRNKGALGSPNSDKLMSDAYVQQRTQASQAGQSDRTDGVGHSSSSQTSGSSSESSQVVGGELPETLSITANTHVSGDSKLRSTSGVTHAPDHAVQKPGSGGSGMAGSPSAPQHVNDSLGTPTAPKVTTPAIPGSNIRVGSGDGDARSAGGAGDSKSPVVPAKQIATASSGDTPKLAKLTSSESLPSRGQSASDNTHGTDAIAAAPSESSYAALRRDAPMSVERKALAEIQRSSPRLEKTSTPAPIVAVSQDAKQGAEGTHLNDEHSTVKRGIGVSSAVQQPDSGTRIPDTRSSDSPADVNHPRTTEQTFPTKPIPQALKRSPDDKGVASGTVVTPSIEPASASDVVGADGGDGVTDRKQDVNTRGRVNTEEQQGGVANMLRSTGIVLSPSEPSFTLNPGRQRSTNPTLSGKSASAPNSDAFGDSEGTRAATIAQRDPAAIAPSSTRDNSSGDGLRETASQRGGDSSVSSVMPISSRFPDNENSVLNTQTPKGPSVQLITSDTIRQGGTGSKPESEAEPKQGIPDVNQQQNEGSVSGGENGIGDSLQIPPAAPPATLVQPYDAAANVQRSKGQIINVREPVELKPSPISRGPSPSNLTPRSPGSAGKPNNHGVELQGDVKNRAQPGVSPAAAHTLSVNVSGQGSPLSGVHPSVGEKVAGGNTPSALTMQNGEPLRFGRAGIPPANLDSLSTEDEDDEAGGGGGDSSKAQAADSIGHVSTGQHPGELQKAEQLQIKDASSSGPLSSVLTGDLGGTQVLGDPASSAIGQSNGGFPRKITEVTEPGGDQPSATLSSFSGEVIPVGVDGGAAGASGDDSQYSASRLKPNTSLSDAHFPPLGAERSDSSLSLLPGQPVVQGADSVGANMLNSQRLPSQDTTNLEDASDKRADAVHSGVLGLSADVGQTGSSSSHFGNKLSAPPEPTRSSNAIVRDNIGVGERVVNGDLWWKPDGWDYKADLKEKWKQLKTKEEEALKKQAEADLKQQKGLQDYLRHLQPYKTNYVPYMHLPIPEPSGFAVDGEVVGNDSDTEQQRQKDLIDLHNARHMESLRLKAQRDREERTKLQKEAVERYKKDEEERHKTYMQNVSDPFTGIVAPNARGLSGNTLPTEFPHIGVAVGYPIKQPRLPRNTVKPADPIEFNMKRHSRQKREAPPIHNDIPKISWVPPPPIKSPSAPPPQPLVDFEVEQVYKAKSFQSDLLKPSHMPVELIDPVLPYDNYLGPPQHVPLPEGSAQDVKTTATVDFCLPAWTTEIPTNDLSDIPETELFPLVPPRTVRDMLRWLVGIRNPKHLQVLEKCINEALGTVPGATTANSKLCVNNSKITTENVIDALKMASMFSCSVLSAIEPEWRQRMPSSTANAEDTDQDQGSDGCALLCRLRDYVYACHHQLTFVKSQCARDKLDGGWLTSQFGLDVGEDSPIQAFLTDDWNSKFETHLFNPCDVCLKCRIRMGFRKDIFSKTAKSGSYLSYILSASFSGDDPLLTLSAYLNCITRRTPRTTGELVSFFHHFGNELHQNNEDALSPLGAALSTSHDNCPNWDHLDGTDLDAARELRGSNASEHDHADTMSTLLGCAIDDSQCVQLLWPITYRAYAIYSPCFAHSYLSWTVYLADILQESLERLRYDIKRHEYSKCASIYHCRDACSYLYFHGFTPPRGMSLSLVKCSDIVGKLEEVVSGGPVGKLLTCMDAFLYGIRRPFIFLGFTFWSVALILLSHTTLYRLDVLRVRSHFMPSRGSHVIDVKALLAHGTKMPSLYDIKYFDDEALAHAWNRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ7</accession>
    <name>A0A061DAZ7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768280.1">
        <property type="nucleotide sequence ID" value="XM_012912826.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564635"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212360"/>
    <dbReference type="OrthoDB" id="366938at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="820"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1673" mass="186975" checksum="C59F9D85B168609D" modified="2014-09-03" version="1">MLLRSLKNLLNTKCLEDCKKQHGKYPENPALKDIESKLQQVKKLGESLKGLTDNNNCEKLLDNLCTGLETFLGFNKDSKGYDGSGIVYSDLDRLCDGVMGFLSGVLGAVKNENEVITYDTDKNKDINTVINTLNNKIGSGRTGLLDAVGAVKGWLEGYRRQIWTLTGSVNIEIEKLKDDIINKESMNTVSINDNKPLKKQLEEWTTVVEKIKNAARKIETNHVNKLDYTLSNKINGELNVVKEAVKMLKESAEQKEFKAQAAYVDEQLGRQKREVVNKIKYECEVLQVRLNDEIKKILLQLGHLGDEKRKHFEKIREAISQTRDAITENVTYYDSNYTDKIWKHLYEIKMQLENYVKDDKSPLQTLCKAVQSEAKDLDKRIQDDLYKFKVSINGEIFDHVKKYLKTVRAAIPELENVYKRKLVAVRDAVIGAVGNDGNLGAQKSGVLGKLKDLDDDVKKDLRKLRDRIKNKLDAYVKGQMAQQIKEAIQEETKAVAHHEEAKKTQHPGHLDKITDGIRKYAQGLRTDSIVATVEQWLIKILDKNDTVNMHIDWYIQSKQPSISLVGDELESKRSQAIAFIKPKISNLLKDREIRTPSINGNVTAILSEIIRFHDDVVKAIEQGVDPVKADSIATEVETTLGFGGVSSGTSDPKEYLKSAIRTISLQLILVVRKCAEEIKSFAGMDKQRANHYELGKNVNDAIETIKALGQKISDALGKTTEVDQLGGQILGQIAAQLKDVIDGDGIDDLNLITFNENSGADNALMPNYLKQTKRDISGVGTGDGVLRAEIKNINKKVAGIEGEQSAPGNIKIHDLESYDYKNKKRELNAALKNEKELYEELQKQVGNAFQNAHKDLSKIKDVMKKCHDTRVSLESSLIQIQAELFSLANFVTTLDDKKNQIVGIMDGLKQDINALQNKINYITQMVKESNDAIDSAILDVEKSVRETYKALNAAFTVTQRNLIATTEQAFNEITKEVQLLFNRHQLSDLTALKSLVGSQLDVIRDIITENLTTGSKGFLAKLHETFVVTVERIDGFGTPSKSALSSGAETLNTAFTAFFSKLSKQKDFTFDFDKISSTNDALDNLLKGLVISQHFDHGFTKNLQRLKNRLGQFTPEKFGDGESPAVLEALRKGYPALVGELDKAYVNTYDGADSIVWSQKTNNKDHPSEDSAKCAKVCLSLLSILYSEFKTILKYCVARCKSDQININTELGKYFATQGYKVTEDGKKHWELQDSKGMTGLFICKRMFGSDEHHLYYIDKSKQNALDTLHDCLQIYYQVCHVATFSARKRPCNIFEMLCWVSGLPCNNVYQHLLDDAISELFVDPTKQPEDADGIPVTYISDEPLAAYPQNIALDNTQRAVKRLCSRSHDILTTIAGTGDAYSMYAVDYSTNSLNFHYPSKGEDCLQMLLDVLRRLLPSLKFLHTQCGLSATYHGWSGCQYGRGVKHSNWQCGEHPADESTDCQPRSPLMSYLRDSLPGCLPHQLVSAGCKSECKTCPKSLPGAPCITPLGFRGFSGSTKTGKDICTVLTKFFDISNINALFGLLPKPPSTLPEHFQFALTLSSMLDNAKAASDVSLAFETKTKALSIELYKETSKLTGALQNAYRNQTGHNSSGHSKSTEADLWSLSKDSCNLPHDRDIHCAAYLCSTSSDAYTYLAKKHADLYLSWAVYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB13</accession>
    <name>A0A061DB13_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768295.1">
        <property type="nucleotide sequence ID" value="XM_012912841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB13"/>
    <dbReference type="GeneID" id="24564650"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300140"/>
    <dbReference type="OrthoDB" id="10328729at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595970" evidence="1">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="197" mass="21111" checksum="8A97037F9F37F570" modified="2014-09-03" version="1">MKVFVPAAVLLCAVKSAAAFDFVREHTSSPRHPSLREANSAAATDASYDIKDYIPNIDTLKEHANTAVKNTEGFLNGVMDYMKNVSNLFWSYVPDPQQVYGSSSEGHTNSGVGFLNSHSTVGDSSSFLSAVNTENFDAAINKVAKTGAEYGEWVKDKIADLKTEVVNDPTAQKVMSAVRDAAAPLTSAIESVTETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB39</accession>
    <name>A0A061DB39_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769383.1">
        <property type="nucleotide sequence ID" value="XM_012913929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB39"/>
    <dbReference type="STRING" id="5866.A0A061DB39"/>
    <dbReference type="GeneID" id="24565738"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311000"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45954" checksum="00F9651BE609F949" modified="2014-09-03" version="1">MTSEHAPKQLFRHEVRVGSTTVVITIETIEDLSKPVTGDSEQQAPTLGAKIDNETDTAEANGLGEGENLADVAGGKIPELTGDELISGEPPVDTETTESEHADDAAATADVSPTTNDDESVPLAGDDGSAPITGDGKSGDLADDKTVSSDYSDEADWGMNTSELSAALHSALQSYNAESGDAPLVNRNISGDMDHTVSNTTDSTINEMQEENYEEADKINPLLAENDEDLDTATVSDATSEVSVEEFLPSGDRIDKLHPDDPRTIMTWNVSGLGEIVHRKNVWSRFTQLVEGLKPDIVVLQNVKLCESPMIGRAHVTVHHTNPGFCPKVVEKGDGRATNISYDQQFKDGKLIDEIKKSIFRRYHLVHSLASWRIGGQLIFIKKCFTVCHQAIPLIRAVHYGEVRSQYEVECEVPPSGRFKNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBC6</accession>
    <name>A0A061DBC6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0404860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770187.1">
        <property type="nucleotide sequence ID" value="XM_012914733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBC6"/>
    <dbReference type="STRING" id="5866.A0A061DBC6"/>
    <dbReference type="GeneID" id="24566542"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404860"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596174" description="Splicing factor Cactin" evidence="5">
        <location>
            <begin position="30"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor cactin central" evidence="7">
        <location>
            <begin position="514"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="6">
        <location>
            <begin position="751"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR98001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="870" mass="95762" checksum="6FA421BE7661875E" modified="2014-09-03" version="1">MAALCRPTHICRAVLLSLLLSLTFRAAFASRIVHRTSKEALQSYAVSEGSGESPYPNRCASGRCPKARRTDSEGRFLDYLTRFVSSSSGLLLDDIIRVQLAQPFDAAVQTSFIALPVGEGIASKISYLFGKYSWDIVNTVVLLTSSAYFIYIFLSDPLSNVCISTISSHVIASLFLGLTHDLMPVWLLAVLSFVIEGALYAVLQYMNPGKRSQICVYFTCVVKAKLVYDLFAVLPIEIISPSYTGPAGAIATYVYGTSNFMAVRLNYAILLLITAAAIFRKLPPYVSGAPSGLHEVDLASSTKRKMVCLVGAWPLAALIPQVLCTWLGTHNPIGPYQFFFVPTPFRLSAFESWLALLKHFNRAVGRQRRAVVALVFAYIVIGIGVPLRTRVYKSDPGRGDKSKKGSTVSFGGPDGRVLNFVVATTEGGSTQGDESAPTWTRLWKRKAPPSAADKAHPGPQIAPVNVEDVKESDTKTGPSDADANVGGGHPKRAKQAPATIAQPHTTARTDTDPSSSDDYFKKEDEFMLRQELEKSKLRVKDGRGNELDNLLVSGTPVTSVVDLFDGDDDATLLQHLELLKAHLHFCEDDSKRSLIKALETIVNSRRLGDVAGEVSQSVSSKINSILSTKSVSELEGTVTFRHLHHSLGYESEIRKKMTSDDVVDTNFWEAVLSRIPFFKACCVVRDHNKGAPADNLAASNVKPVTPKAPASRADGSVRAVADPKYERFMKALKLETDEHMLTEDVPYGKDSGRKPQFAARVTLSYDWNSYNLSHFDPNNPPPKSVQGFKFSIFFSNLENPRAVPQWKLAKDGANTDTCLLVFKGGRPYAPVAFRIPAREWDTDPSRGFKNCFSEGVLHLYFNFRKLTYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF9</accession>
    <name>A0A061DBF9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface protein D, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770059.1">
        <property type="nucleotide sequence ID" value="XM_012914605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF9"/>
    <dbReference type="GeneID" id="24566414"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403610"/>
    <dbReference type="OMA" id="CVGHITI"/>
    <dbReference type="OrthoDB" id="10338442at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596178" evidence="1">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="158" mass="16696" checksum="59530EC13BA1A553" modified="2014-09-03" version="1">MVCSKILAIAFCAIAAFSTVLRVEAGCSEEHVQVLGFSSENVTEDSLKRGREVAGLLRKLMLGNLTKTGAKDTTPLTNKFTKTLTKAGYPEIPAECLSCFVQSAQCVMKECKGACIAGDQSPGCVKCFMAHCADDLHACVGHITINIGEHKNAGKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBL8</accession>
    <name>A0A061DBL8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770292.1">
        <property type="nucleotide sequence ID" value="XM_012914838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBL8"/>
    <dbReference type="GeneID" id="24566647"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405900"/>
    <dbReference type="OMA" id="REHYLEY"/>
    <dbReference type="OrthoDB" id="365710at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="115" mass="12533" checksum="B600E6483BE2049E" modified="2014-09-03" version="1">MTYTALSPGMVVAPISPGTYLLPAVSGPDSMLNSCVGAGCVNTTHDKIFTYTPKEYSANLQFMIMCVPLCLIGVLVVCLIVWIAITAKSRYKAYEDALDQRLIDAMSEEEKEVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM3</accession>
    <name>A0A061DBM3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LCCL domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0312400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769523.1">
        <property type="nucleotide sequence ID" value="XM_012914069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM3"/>
    <dbReference type="STRING" id="5866.A0A061DBM3"/>
    <dbReference type="GeneID" id="24565878"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312400"/>
    <dbReference type="OMA" id="AGENLCG"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017229">
        <property type="entry name" value="Scavenger_rcpt_PxSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037512">
        <property type="entry name" value="PxSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595657" evidence="3">
        <location>
            <begin position="35"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="4">
        <location>
            <begin position="167"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="6">
        <location>
            <begin position="287"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="408"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="534"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="6">
        <location>
            <begin position="692"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="6">
        <location>
            <begin position="1144"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1265" mass="137188" checksum="DCF459FA7A9E7EED" modified="2014-09-03" version="1">MLRRLHIRRRGAAPLPWLALCTIVVAFLWRIASSDEWCKVATFGLEPHYEQCLPDGDTLVRYTIEVVPLRLDDMSLSADVRIKIIGDGRETKPITIASIDGTHTRLNVERIDVGDPRAIELDSGTSDWSCERITVFRDSKYWIFDCVADGSAGVVEDRPRYLLSGNKVYTVSIQTGSYKDSGTSGRISLMLIGPLGKSNTKSLGTNFYAGSYLTFVLKAADVGDVTGVLLSNSATSDPWYCEDIRVMSSNESVKTFAVKRWVGSPYESSVEVTTAEGTSVTNFNETTPMDIQCHTRAIDLYSGPVNKPFNVTVRCPMNCQASALVHVVGSSLHHSSSSICTSALYDGVLTPSGGEVVVSIVGALKHYHGAVNPFNHMESESYEPSPDKPYYSFYTFLNESIDNVESNVRLVDAYGRLSSFGRLEVLKNGKWGTVCNKGKFGAFNEAAANLVCRKLGFKHGVHVMESCSSVNDQNMCVPRGYAVSYAGLMCLGTEDDISSCIIEEPTVDCQSHKDDVIVKCTNTMPRDGIPFGTLRLVDASGVPTSTGTGRLEFYNDGFGSVCNESWSKAAAKIACQEMGYIGLHNGGLVGQDCSDVHGVNLCAPVTQKIAAVDFQCKGLERALGQCPHESADDIYCTHDQDVVLSCAGNGDPSEFRHQRRTEPFTPVMKKLPHAVKLTCYDNMGSHSELQTKHGDFAIAICPPGCKSDPAALKGTFIYTEDSAICKAAVHAGVLDDSGGEIVVIRAITQPTFYGSVMNGVTSLGAHKMASEFQAGAFLVSRATKHILSKQMKLQHATGSQADPKPLVGADTPPSPPSVRWFPEMGWKGFNGSAADFVSLRNFPNTEKLKTLRDFTFIVQMTPTELVGKWNTLFSFQGCGGLTCTIDNAGEMVLEENCRPELFKTTFFPTLGRRTTIAIVYYSPTRDMGFFVDGTLIASRSTEFDFSFQGDLILGKSAETDSDFFVGQLLSLEVFDYVMPPDQVMHHSRMLQSLDGNRIHSRHSSTRMTVEGNMCLSKCVRMRSPAHDSARHGSPTNPAIHLACHNTLEDERFNGATGNEFLVSCSRSCTDPLLVLKGSKVYTPDSSICKAAVHSGAIPLEGGEAVVTILHGQDSYDRCVGHYGVLSNKWNQPHMRSFSVRRAPRVLALSCQDPGLFVLKMNPGTRTLLRCPPGCLDNQATNVFGSGMLSVAANGNAVLGVYNPVSSLCQAAIHSGKLDNRGGEVEIEVLGSQESFAGSTANGVTSLSSGQYLKSFRVLRGTVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR9</accession>
    <name>A0A061DBR9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylosuccinate lyase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0302130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768495.1">
        <property type="nucleotide sequence ID" value="XM_012913041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR9"/>
    <dbReference type="STRING" id="5866.A0A061DBR9"/>
    <dbReference type="GeneID" id="24564850"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302130"/>
    <dbReference type="OMA" id="NNWAVVA"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047136">
        <property type="entry name" value="PurB_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006764">
        <property type="entry name" value="PRK09285.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43411">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43411:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="62"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Adenylosuccinate lyase PurB C-terminal" evidence="5">
        <location>
            <begin position="348"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="476" mass="53960" checksum="3878CB5B5DADAF12" modified="2014-09-03" version="1">MEAVVQGDHMFVSPLDTRYLRTSSEIATHLSEYALFRNRIIVEVSWLRFLVNEGVTPVSSLDESSESFLSEICRFEPIEMESIRQIDRKVNHDVKATEYYIRVGATLLFTSLLQEKMKASGIPQLESLEHWIHMFCTSEDINSPAYSMGIRDCMEQVIKPTLLRIIDALCSFSVENAGKAMLSRTHGQPASPTTIGKEIAVYVHRLSRQYKKYLTEVDYMAKFGGAVGNLNAHKFAFPQMNWQELAKRFIEKELHLVYQEYSTQIECHDFISELSDNLSRINTILKDLCVDMWLYISNDLIKLKGVQGEVGSSTMPHKINPIDWENAEGNLGIANSLFHFFSSKLPTSRMQRDLSDSTVLRNIGVAFSHTYLAYQSIIKALSRIATNEARALKELDDHWVVLSEPLQIHLRLSGVSSGYEEVLNRTRTGCVSKDEMKQILADFADGDARLESLTPSTYIGYAESLALGIKDRCAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW9</accession>
    <name>A0A061DBW9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0302880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768570.1">
        <property type="nucleotide sequence ID" value="XM_012913116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBW9"/>
    <dbReference type="GeneID" id="24564925"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302880"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="62" mass="7123" checksum="F45992C0FF6C0142" modified="2014-09-03" version="1">MANTSKLTTDVTLVPEKSGLDETMRDSLIRHKILKSHEIDSIFRTCKNHLSREMEKRISPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC23</accession>
    <name>A0A061DC23_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">-3-hydroxyisobutyryl-CoA hydrolase-like protein 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0400440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769738.1">
        <property type="nucleotide sequence ID" value="XM_012914284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC23"/>
    <dbReference type="STRING" id="5866.A0A061DC23"/>
    <dbReference type="GeneID" id="24566093"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400440"/>
    <dbReference type="OMA" id="EIIHDHF"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="443" mass="50862" checksum="62C4B8F7EEBEF4D2" modified="2014-09-03" version="1">MGFLFSIYSGISQINSLYRRLADLETNVYKRFVVLTSMSRDIFSKGLNSLEINMFKEALQLLSNHKNGAVLYGVIQRALDDYLSNICDLSYLIQSYQKPLVSYANGTVGGFATSLVSLANVSACHKHSRMIFNNLEHGIPLLGGQSCLLAMMRGSLGEYLVLTGHELVGADLVWSGLVRRYVSPDAFHVMQLTAERQVEMPEKETEFQLQEHFLQLDSRYSLDRFEWLIHEHFNRSSVASIIRSLERGVSAKKLRSNSSINAELARKWEMKTLDTLTNHVGRHSEEYDIALKLIREVKSYKLQVLKTLDISPKRWIEMRDFVHRPPVSTNDHKTAMMFHSIHSELLLESLQLEVASWLGYLGKVLQLPSGDLWSQSKFSSHPFTPCYRSGFSLSSLPALRRLHPDFDARTGCDHDAVRMKRFCERWSDDFLQRELFLMQRILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC4</accession>
    <name>A0A061DCC4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="10">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0402080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769903.1">
        <property type="nucleotide sequence ID" value="XM_012914449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC4"/>
    <dbReference type="STRING" id="5866.A0A061DCC4"/>
    <dbReference type="GeneID" id="24566258"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402080"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="11901" checksum="D1DF32613397F54A" modified="2014-09-03" version="1">MSSSKAQDATSAISEDKDKPAGPLAVLEACVRDNSQVLINCRSNRKLLGRVKAFDRHFNMILTDVREMWTETSRGGGKKKYVNKDRYISRLFLRGDSVIVVLSNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCD5</accession>
    <name>A0A061DCD5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0305520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768835.1">
        <property type="nucleotide sequence ID" value="XM_012913381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCD5"/>
    <dbReference type="STRING" id="5866.A0A061DCD5"/>
    <dbReference type="GeneID" id="24565190"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305520"/>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="722"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="936"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="936"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="977" mass="111315" checksum="E158D2C3EC3EB013" modified="2014-09-03" version="1">MATNVQSKFWGDDSDSSYSDSSGYSSDAGDRDATKRQAAAAWVASDSSSDDDENRVVRSARAKALEVIQNYSKTMEHHKSISDFSELLKDYDNVARLVEKQYAKSRIPKLIVEVILDLQQFVEEKQKDKETMKKMSKARAISLNTLRSRLRKFNEQHADVVEEYNKDPDAYVDILKETSDEEDSDDDYDSDSESDSDESDEASDDVSEESESESESEEEEEDEGSEGGDEESMKEEGSEEDSDYSDWSDSGVSSLSDNDATDKHESALAKWGVKKSESTVKVAKPKTTVKKPKAKTVKKKDDRERQPTTSGMGVTATVAMVADVVMPALDKLELSAEDDPFGVSTPEIDAVLDKVFLSADNVKEYVKSIVERRGKRGGNTHETIRHLKTLPYIAKNTSHSLYIFVVETLLHIQFDSYSNAYGAMLPKQWIDSYRIVSHLIGELRDHPQALLSSESMDSDDPNAEDSQGEKEAGAPGQTREGRLERSMTILESIVRKLNDELYKGLLYIDVGSDDYNTMLVYNVNMLYLLHKTLMYCLSKGKECMKHAAGIAIIMLEHLHYKDDVVSGKIWELVRQKATPKDDTSLFFADEGKKASDVVEELVYFVFEHGATREKVRACLHLAFNKALHGHYFEARDLLLTPNIHELATETNISTQILLNRNIAQLGICAFRKGYISDAHSYLMDLCSQNRHKELLAQGLSMLKNYEKPPEQERAEKRRLLPFHMHLNIELIECINNICACLLETANLAKSTINSREIISRQFRRMYEMYDKQVFVGPPENNRDMVMATFKHLQSGNWKDCYEQLASLTIWNRLPDKESVMLILKERIKVEAFNTYIFKYVSVYDSFSVDQLSDMFDLNPNVIHSLLSKMIISGEIHATWDDSSKCCLINHTEPTDLQKLAIKLAENLTTAVEQNEMTLNMKNPKFALSQDRRFQPRDSKFSYGNRRDDRHHATPNFNRNRRQMQNNRHQRQTPVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE1</accession>
    <name>A0A061DCE1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767686.1">
        <property type="nucleotide sequence ID" value="XM_012912232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE1"/>
    <dbReference type="STRING" id="5866.A0A061DCE1"/>
    <dbReference type="GeneID" id="24564041"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206580"/>
    <dbReference type="OMA" id="GWEHFMV"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="26265" checksum="EAE879F954F31D47" modified="2014-09-03" version="1">MGEDVCLQRAAFGHGMEVAPGIEDGFPGEMFFMNAKDCIDGYGIQSVKGTFISPKHIRLARGCYAMASDSDREVDTLDQHSPILKNKRGRSSHFSFWSRVDAGEIKIQQTLEEWRLLASATPTYEVHKNIANYEISTTNLGDYPYKSTPYGDVYYSPRYSDHKYTYRFVILTKGVRNEAHRILKNCGTHFLTEAQIIHQLGIDLSPGWEHFMVYRNRLDELILRRPFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCV6</accession>
    <name>A0A061DCV6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770213.1">
        <property type="nucleotide sequence ID" value="XM_012914759.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCV6"/>
    <dbReference type="GeneID" id="24566568"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405120"/>
    <dbReference type="OMA" id="HCYDLLH"/>
    <dbReference type="OrthoDB" id="421917at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0168">Coated pit</keyword>
    <keyword evidence="1" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="569"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="874"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1469"/>
            <end position="1612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1676" mass="186812" checksum="D279C50CA3CDE925" modified="2014-09-03" version="1">MAGAPVNVTTVLRLKDLGFDDGCFRFGTLTLGGDRFVCVRESEGASPSVAIIDLHKGGDVSRRPIKAEATIMHPNEFIIALKASVDGGHFVQVFHLETKEKLGAHQFSEAVVFWRWISSTTLAVVTTTSVYHWTVRSGEPVLMFARSGKLADPSTKLVHYASDDNAKWCMVCGIYSLDQGATVEGSIQLYSTERRQQQLLEGYTGTFGRLRISKDNFDTTGLLVFCEHKRGAQTSKLHCMDIYTQRTEGAPAPLKVSKEIENIATTMGDFPIFVQILDSCGLICVLTKNGFAHYHDAATALPLFSRKISDVPLFVADAKRSEGKAVGVIAVNRSGDVVEAIVDENRLLSALSCPDEVRVSLATRFGYPGSENLVMRSFEDYFSRRDYKQAARLVASLKNGALRTPEIMERFVNAPALPGESAPALHYFSVLLEHGRLTARESIELVRPVVAQGREELVKKWLDEGKLTESEELADLVRSLSPLLAFKINVSLGSHFKAIMCLLDAGHAEKVVPYIRKIPLSDVTYVTGSTGDRVAQIPGLPSMDAIVDHMVNSRSADIVGFVNDLIAGLGPGECLCDVGQVTEVLIKNNKLQELTKILLEYLKPNREQHAALQTRLLEVNLQQQPRVGEMILQMNVLTHYDRSYIARLCESADLFDLAVKHHTSLFDIKRIVIKAGGKLSRGIFETTMKAMTPEQALEVIRDMADSSDVGNHEVVSSALSLHNHIGTMQLVQTFERSGSSDLLFLFLKALPVISQAALAEKTELNATLVYKFIQCCIDRAEYDDLERVCKESNCYDGLRVKELLKQSALPSPKSLMIVCHKLGDLAELTEYLYRNGMEKAIEIYVNTINPGGVAAVVSALFDIGAAESTIHSILENLKDSNGMIAMIKVADERHQLLMLKDWLQKRVNDGYKETEIHTALAKIRVSSQQDAEEFLRTNTHYDRAVVGKFCEERDPMLAYLIYSQATMDDDVLRVCAGNSLHRMLASYALKRSSARMWREIFSADSTAVKPEDRKHICEELVSLAPESSNAAEISCVLKALLDANMDAEVIALLEQLLLTQTQFASSGNLQNLLLATAVRTNPEKLEEYLPKLDNYDVTALSKLATSLGRTRSSFSILKNAGRHLDALDALLNMKEEGILKEAQEYVESVDQSEMWFRLGRAYLEHKELSPAIDAYVRSGNPSDHERIKEACGKDTDLLLRWLRECRKVRENRQIDTDLLLCLAESGNTDEFREVLSAKNCADVAYVGSKLMEAQRYAEAVIVYSSVPNHSKLAVCHLNLDNFEQAAETALKARNPQVLRQVVETCVLKNQLAIAHNVAIELLTYPDFLPGIVAMYENTGNVQEVIHLLENSERSVAVCTELAIAVAKYRPDDLLAHFKNRYTGESIRTSLNIARVARECCNLWLWREAIYLYRLESPDKALMSMVSHYGLAWDEEVFFAAAGEAANPEALYKAIHFCIQCEPMLLTRLLISIKNRVDPIRVIKILKNADCLGIAREYLEAVADKSNPGVNDALLEVYVEEEEHELLERSIVRLAVFDQQALCAKLEGHRLPQMRSIAGVLYARSRDFSKSALIHRRNGDFAGAIKAVNMSRSESLALEMAKYFIEHGLREEFVACLTVNFGLLEPADILELAWVNALDLDILMPFMIQTLRTIPRNAARSFSAQQVPQPKLQLGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCW6</accession>
    <name>A0A061DCW6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769125.1">
        <property type="nucleotide sequence ID" value="XM_012913671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCW6"/>
    <dbReference type="GeneID" id="24565480"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308430"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="103" mass="10901" checksum="40C8FDA4CB13E03E" modified="2014-09-03" version="1">MQTIPHLVEGPDAEVAHDADDEDDEYDEDDDESDGGSGSGATGRIGGKMFTGLKTLRAGGMRNTGRWGCPFLFTTVTFTSGDGIVFEVYANGSIANMICNGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD70</accession>
    <name>A0A061DD70_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ mediated genome instability protein 1 OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768191.1">
        <property type="nucleotide sequence ID" value="XM_012912737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD70"/>
    <dbReference type="STRING" id="5866.A0A061DD70"/>
    <dbReference type="GeneID" id="24564546"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211490"/>
    <dbReference type="OMA" id="MCSSTEL"/>
    <dbReference type="OrthoDB" id="434939at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="2">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="357" mass="37238" checksum="68BA6E12F131170A" modified="2014-09-03" version="1">MDVACAPVPRSASRSALQEIRRAWNLEISPAQAAEIARQGGVDTSATALKRVLLNTDISSIPGSADNAGTAGPGKGGMCSSTELDALPRPLLCQVVKVVDVTQPKDGVARKDGTGNPLYKVTLTTGQISFHAVLLDEKMPIMSLAPGTKLLLTERNVIHTDGIALLRPNHYEVLGGVVAELKTPWAIQREVNFQRFSDGARRIVSDAPKFEPLDTSSLKAATDMAKLSLRPPPPKSAKGTPAKETGAKVTKAGAPKQGKMIKPAYKLQPDKKGGPQHKAAPQRGSSEAPAAKDAVPRATQPPGRGRGKGAPPSKAKPAGARPPPKTSSDRAPKKAPSATPTANPRKNAAATGRPNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA7</accession>
    <name>A0A061DDA7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769420.1">
        <property type="nucleotide sequence ID" value="XM_012913966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDA7"/>
    <dbReference type="GeneID" id="24565775"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311370"/>
    <dbReference type="OrthoDB" id="366289at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="227" mass="25782" checksum="95E744973D60BDAC" modified="2014-09-03" version="1">MITRGVAPRRALPAQAAFACLAARKHHILCVCDLCYNHQSRGNQKGTCAPLYDPQIELAYPKASQMGKVSPRRRRRAPTKGIPKNAVIVPNVPTEDYCSQMPGVYYHFGKLEWRTTCRDPFNCSKRSQRTFGVRKYGFYEAKTMAELAALEWEKHRNLVLYLQNVSTGNAIAGHVIATPPAPPVSPEYIPYMPYDCYAYVPEDFEGPYTQQTSMDYYNESPDRLSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDG0</accession>
    <name>A0A061DDG0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769550.1">
        <property type="nucleotide sequence ID" value="XM_012914096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDG0"/>
    <dbReference type="GeneID" id="24565905"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312670"/>
    <dbReference type="OMA" id="HAPEEDT"/>
    <dbReference type="OrthoDB" id="329189at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595725" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="131" mass="14392" checksum="33DEB393A87CFCD7" modified="2014-09-03" version="1">MLSGSVGAIISLWAVLSTPATHSISQQQKLSPFGPGMRNAVMSGIQDSADFAVKIHPPVEDLDETLKSLDGIMMMEDAERRASNEDFVDAEQRLLAVHKAKIREIVAAAMEPIHAMFPVKFQEVMEDDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDN5</accession>
    <name>A0A061DDN5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768601.1">
        <property type="nucleotide sequence ID" value="XM_012913147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDN5"/>
    <dbReference type="GeneID" id="24564956"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303190"/>
    <dbReference type="OMA" id="IFELICI"/>
    <dbReference type="OrthoDB" id="10339245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="422" mass="48038" checksum="44A549C642C648D1" modified="2014-09-03" version="1">MWRRCLESLRPRLKAHFTNENRSKVALLGGCCACVYLNGTWLYMRNRSGESAECNRLDGPIPQVKNRLFISDFISHFSPYLLPTFSRGGWMSEFEKIVDTGSSEFRERLMAYLCLNKVLRNAVCVRSLFSGSKKFDLVMSDIVNPKDLPSSANKADDSDKKEPELLFNVKMSCLEQYLRAIPKEERKVEYEDLAHLIKLPKLYPSAGANEKVSRVLRLFFENEDNCVMVAKKEFEAFESCSLINNNENKASDMVLTYLYSTKSTKSWFSALLSDTHLTAVNNAESIDMINKAVRSQEMALSPLAVSRVNFDGLLPVLSAVEISYAFAFLRTIFSGKVPGVDRGSKFQMALMEGCKTTRGILIFHGIFLIQSKLINSEYYFKNEDYMIPMSLAMCSSSWLALSALAMTHRHLLFPLMVHRFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP6</accession>
    <name>A0A061DDP6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BOP1NT (NUC169) domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0303490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768631.1">
        <property type="nucleotide sequence ID" value="XM_012913177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP6"/>
    <dbReference type="STRING" id="5866.A0A061DDP6"/>
    <dbReference type="GeneID" id="24564986"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303490"/>
    <dbReference type="OMA" id="MRPAKGE"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="79"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="698" mass="78557" checksum="E3181B628B20540A" modified="2014-09-03" version="1">MAPSKRNGKARSRKASPAAASSSSTRSSSRSTVKSAPTAQSVPNSPPPVPRDVEDDGYFDSDEEEGSLNRIGRVPLSWYDNEGHIGYTVEGQKLAKELDSTEIGKLLFQSDNPDAWRTIVDVRNNRTVRLTDEDLKVLTSCYTRHDMSADQPYPEGENYNQEDLYIDFGNEDAIHPVSNKPPKKANFMPSKFEAAKIRRLVKLIKSGKLVVKAEPDEPPEEPIEDIWLDCIYQVDPKTARRGRQHEISAPKAALPTHSESYNPPEEYLLDEEETKEWLETEPEDRKMDYLPQKFDCLRKVGSYENLILERYRRCMQLYLCPRAVKLKMNVNPETLYPKLPDIDTLGPFPSRTSVEFRVSGTRKVSIDCTGRWAALASVDAIHICSVLNGRVFDRVEGLEKIYDICWHPRYPILIVSHGSTMSFVAIELPNLRPKSDDQPSSRKKATETEEKGAYEKALEMISLSNASGGWRSVRFGKHEALSVDHVDELHRVSVHPQGNYVVGVSPHSRESGNQCVIYCLTKKTFIRVGNKMSNNAIRLAMFHPLEPKLILGLRKGVRLYNLKVKNEKLDSEGEKLTGVDLPVSMHLNRGAQILAVADENGSVVLFDLNVGMYPYKKFQFKGEQIVKVEFHPSLPLLLVASSAGIVHLIHVSVPDDLSKDPVIVPLKDLKTYAIADAKWHTAEPWLFTAGAREGLMWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDR7</accession>
    <name>A0A061DDR7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768691.1">
        <property type="nucleotide sequence ID" value="XM_012913237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDR7"/>
    <dbReference type="GeneID" id="24565046"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304090"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="128" mass="14127" checksum="BFD238E386455EB9" modified="2014-09-03" version="1">MEESKCTCSLSRGRCDEASCVQYVQISHLSEILITVNIRTVRSYVDSIVNADVVKRNVYSVSSVPSSSPSSPSSFSSICSSFTFCLSPKSANTSSENYRFASHFIIKSITLYYRNSLNDSNIKAINLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDW2</accession>
    <name>A0A061DDW2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0402280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769925.1">
        <property type="nucleotide sequence ID" value="XM_012914471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDW2"/>
    <dbReference type="STRING" id="5866.A0A061DDW2"/>
    <dbReference type="GeneID" id="24566280"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402280"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="24615" checksum="4D3CD238E7C2D1B0" modified="2014-09-03" version="1">MTDTLIGIRGKDFVAVACDTYEKYSIITIKNDDESKISQIGKSTVLMLAGPLGDRVHWGEQIKRTMEYYKYKNSHELSASAAAHFIRLELSEYLRQSPYQVDMLIAGVDKDGPSLFWIDYLSSCTAVDTAVHGYGGFLLRGLLDKEYKPDMTREEAIALLKRCRHEVKNRFLLSQSNFSAKIIDEQGVHDVSIDGDETPEIFRGRVQSAAIPMDITMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE49</accession>
    <name>A0A061DE49_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0307240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769006.1">
        <property type="nucleotide sequence ID" value="XM_012913552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE49"/>
    <dbReference type="GeneID" id="24565361"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307240"/>
    <dbReference type="OMA" id="YEFDTAN"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF22">
        <property type="entry name" value="PROTEIN ROOT UVB SENSITIVE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="3">
        <location>
            <begin position="55"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="548" mass="60376" checksum="40652087ACECA707" modified="2014-09-03" version="1">MLERFAIAAAMALASQTQPMASPAGEAATGSGASKDGEAGKASNDRWIAWMTRGKVSSALTNIVLKDVVSRAFNFVWFGKIGAGFDDNPKAFRLLGGLLCSVAGVACFAGNVMKFEPKVLLNVCINVLKHVGMLTMLAAQAAFHTTFCVKNAATNVGEITAKLEAQSPICDFIGMATGMQLGTLLADKPLAVQAGVFSGFCVVSGISTYMCAKSVCFRTLNPQRCFVLLEDFASVLLRRLDRYLRYHKMRLEALRHRCSGDQGADSDSGDDSDSDDSSSHSCFEDDECGAIAEMIHDYEFDTANRLLHRFTSKHLCNKLKRAREAGTAGEEANVRYPNEPLNLVQKRIGMKFLTPEQVAAREPLLFPWRDGALKHGAVKYSLADMSVCPATLAEYLKIFKGERFVVALGSDGIVECAIHRSAKPRDAMLAILTYNIAEKLWTLLDESMEPGFIDHQLEQIWDLCKRSAVSLKEVLVRLNAQVNAHHPNASRATDMEQLREEMQLWKWGLQTVRYAYNVAKACIDEVMLSAQAAKWDVEKFDLCSPFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE69</accession>
    <name>A0A061DE69_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ska2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769061.1">
        <property type="nucleotide sequence ID" value="XM_012913607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE69"/>
    <dbReference type="STRING" id="5866.A0A061DE69"/>
    <dbReference type="GeneID" id="24565416"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307790"/>
    <dbReference type="OrthoDB" id="193920at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042091">
        <property type="entry name" value="Ska2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16740">
        <property type="entry name" value="SKA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ska2 N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="28176" checksum="72CD8172663614FA" modified="2014-09-03" version="1">MASSRLRQPQAVEDALEFVRNKFADVGNDLDLVEKKLTAELGAVFGPDVFQLHGRCQDLKAQINKITRDLAELYEARKELVNVIGNQLTLSASLKNFERMIEPHAKVDDDTHSMEMLGMHYQAIWNGEEFEVQEVEEVETARPLTPLTAIGYRRSSSTTYRPWSKGAQSWNRSTNCTSTSLTRRLSAKVKLKEISQSGIQVFGQTGKPENARLPDTFRVFQIGITETVTLLDERFSGTHHKIRKLMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DED0</accession>
    <name>A0A061DED0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769251.1">
        <property type="nucleotide sequence ID" value="XM_012913797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DED0"/>
    <dbReference type="GeneID" id="24565606"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309680"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="157" mass="17475" checksum="1B8AB0FF48CE59F2" modified="2014-09-03" version="1">MEDGQCPWLRCVLMSGRLRGLGVEREDELYSTLYVWHKLYRFFGVVSGSGYKCDPSACEKQCKQCSNPRCQCECPCCKSRNGGISTPDCSSHSPGAASSRSQQQTLTLPYSTSPSDSQSSSPAPYIIAAVALIIVVICAMVYFRIRPFHRVRYLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEL5</accession>
    <name>A0A061DEL5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769676.1">
        <property type="nucleotide sequence ID" value="XM_012914222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566031"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313920"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1588"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1650" mass="183953" checksum="86B7152F12018E32" modified="2014-09-03" version="1">MAFLCGVLSNIKEHLGQHKETITDAINTLNTNKHAGKKGFSVAIGSVVEGVGRYNERVKRSNDEIKKPIKNLQKQIDKNIVNAVKSILPNENAVTNDALMQAVELIKSKLLECKQFATEFNEALNTGKKEEIRKAIDDLNPRLQECVRNALKAVSHESQRLNELSNKESEDFEVTNRIITETLQSLHTQMNKHINREVKYLVEQFKRLAKDIWKQLNAIDTKLEEYVEELKKWIDASDKIVDTTIYEAEGIVQKGIGKNQQNSIKRVGEQLERRRKDLETNINGVKRKLESLAQQVTEQADSLEVNVRIGLQALRDDISKMLNDVRSSSAVNGVVKGLVGKQFQSLTESKNELTAVIGRITENSASLGSLYIKAFKQKFYDFAEALEKANLQKFQNALSPKSRKLESYVGILQRISSMLNVQPSTAGSIMELVEELNSGMRAITEHYDEVTSGTPSTVKNLKEAVDKAAGAINALGEKLKTEFHPAKEEIAKIRDDPSLTTAVAKYNALIELKTTVYGQTGGVENPDEGSLAKLIEELTKAVDGSGGVGGLKKAVETFDFAAKKQITDGASAAINEVLGKFEMDTVSDPQQINVKSMMNLFSLANESLKSTVNEIKTHATDINVDYVKSSLHTLSTELPKYLSELLDALSASGNAIKQNLQKLKRDIGKTERGTPAKDTLQHIHRQLSELRSKDLKSTITFVHGLDAFATRACQETIEKLENNVRQEVEAATVKLTTLIQKRFVCSTKSLLEKFTGKVNGELNGLSAKIHNDLNTGLNGFMLRLETHFLTGEQVIQGIDKISETHSPKQKSPLSQGAEKFNTAVKAFFGSLEKQKDFTSDYKIITPAKEALRKVLAMLAERGHFDHEFLTNLDPLETKVSEFKPSTYGEGKNPFILVAVRSGFTTIVTEFQKAYVSRYSGQIYDESHASKYVKVFATILYTLHDSLNSLNKGCMAGGGWNSRQWCKNDKRGENSLGTFLVRCGFQVATDEVSKDGELKHPSDKLSGKTIHDKLLETDYIDTEIAKHLKTCKSNKTKKPSQFNLFDLLECILYHTDKYNEVCHIPTASSTKVPSSVYDALVWFSGLPYSGVYSTLLRDSITDVLTDKDKHKAQVLDGLEFTAVDEGSLSIPAYPSDITYERVDKALAHICSMSYDIVTAIAGHGDAQTIYGSEFCNNSFKFKYPKTGDDCLQMIVDLLRRVLQCLRFLQQKCRLGAKYHGWSECLYGKSVKASNSPCEKHSTDKAECQPKCKVNCQPNCQPTSPLMSYLYDSLTGHLPHDLSSIGCKSTCNTCPKSSPGMPCLTPLGFRGFSGSTKTGADLCRIIDIFLNFDGLSCLFALDPKPPSTLSEHFSFVLTLAAGINATTTKRKSDVKTLRESFEESIDKQSIKLYENASSFTSALRDAYNSNKNHNANPHPDATNADLYTLCTDKSCVYPNRNVYCGPYLYSLSSDAYSCLAIKHSGLYLSWALYLPWTFYQYLKSLLDAFCAISCQYWGCRSCLIGDTCKPGKHGVDYNCKCNALVRCRGVLGAFYGYGFTFGDSMKLLEQHHRRYCHDFTKQLQNVLTSKCFGNLLTKCDDFLWQIRLPFFYLVLPLWSLSLFYLICVMVGRLDVLHIRSHLRIPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEM6</accession>
    <name>A0A061DEM6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769731.1">
        <property type="nucleotide sequence ID" value="XM_012914277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEM6"/>
    <dbReference type="STRING" id="5866.A0A061DEM6"/>
    <dbReference type="GeneID" id="24566086"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400370"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="entry name" value="bipa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048876">
        <property type="entry name" value="BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21018">
        <property type="entry name" value="BipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="28"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="627" mass="68850" checksum="6A2B1D38A722D137" modified="2014-09-03" version="1">MIIRSCRLFSGLFRCAIRPSCRLQRDFTSIRNVAVVAHVDHGKTTLVDGLLRCSGEQLTHSRAMDSHELEKERGITICSKVTRVEWSGHTFNIVDTPGHADFGGEVERILNIVDCVCLLVDIVEGPKPQTTFVLRKALENPDLKAVVVVNKCDRDCNKTRSDIENELFELFVDCGASDEQLEFPILFASAKENWVSSSYPVDRHQVSGTSKILECLSHVAPSPKVSKHTNFTLQVSLLDFEEGCALITGKINSGSIQKGATLHIKDCSNKLKGHTVVKDIFVAKHNGKVRLNGVAQVGDIVTIQCHKGITPEINDTLGDSTEFEPIPPVKISEPVISVLVSANTSPLAGTDGKLQTTAEIGKRLKHEAKRNLTLRIEETAGKDGYYIKGRGELQIGVLLENMRREGFEMTVSPLAAVTTVGEDGVEMEAVQQLVVLCPSEMAPNVVDLLASRGVEVLSYSDCRGGTEKITQLEFQGSTSQLLGLMIALRDITRGRGEISLTTVDYKPYEKDTRNLRKNGSLISSCMGVATPFGLEPAMSKGTLFISEGTRVYEGMVIGESGTDKDIHLNVVRTKPVTGMRNKGGEQIIKIVCKQLTVEQALAYLSRDEQLELTPKRIVIRKKVLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEU7</accession>
    <name>A0A061DEU7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770086.1">
        <property type="nucleotide sequence ID" value="XM_012914632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEU7"/>
    <dbReference type="GeneID" id="24566441"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403880"/>
    <dbReference type="OrthoDB" id="361958at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="201" mass="21800" checksum="8ABEFC3F237742F6" modified="2014-09-03" version="1">MCPLSASLYVGAVGDKLNAVQLESRTTNSFLEAKVGEDNPTTEDVGDDSDQLEPAEAAPKTWDLQAALGDGESLLYESVCLGAAKGKCLQKACSLSRYNDTEWSTPMPVVLQIIAKEESDEKRIVCYQAGTGRIQLNTTVLPTMSVNKLKTKSIIFVGQLIGRDAHINCIAAQVMNPSLRLTGSSSKTNYREMIVTSYFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEV1</accession>
    <name>A0A061DEV1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770106.1">
        <property type="nucleotide sequence ID" value="XM_012914652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEV1"/>
    <dbReference type="GeneID" id="24566461"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404080"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="9726" checksum="1FC761A16FAEB638" modified="2014-09-03" version="1">MEVDRIGVPLSYAVSKLSLPPSRWTDNDEECDISDLHGDICGLYLSTSVVFCCPSSPSSVTIGSKLFQQHKVSFILKCLIHTATYTCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ22</accession>
    <name>A0A061CZ22_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766057.1">
        <property type="nucleotide sequence ID" value="XM_012910603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ22"/>
    <dbReference type="GeneID" id="24562412"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102000"/>
    <dbReference type="OMA" id="TLESWCY"/>
    <dbReference type="OrthoDB" id="364266at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595797" evidence="2">
        <location>
            <begin position="22"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="719" mass="79476" checksum="363A8F2F1D95075E" modified="2014-09-03" version="1">MPAASVFVGVCLLWAFLAAEAADKVQRRFAAFTISEEGPSTPLGFVPQSVEQVYLAYYSGLVDVYGDAEEERGRNLFPDNVHPGLSILSYPKQSASESVGSVRADATVTLESWCFAVTSFFLSSRMPRVAGDADGKCTLDLFYHRCLGLNGHADAEDETDYRSCLVQLSSTSSLEDVYMFEKWSRRCPKPLYADSLSMNAKAAACNGLFSESPSVASLVTGRHCYLHDLLTLDWIPYSEVQRQAGSSLSTMINPDKVAANYMNTWRYLQPSKSAEFQMGFSTSVSDFHNEVMAASSSTKAKNISAFLANQATNVQIRYVIAAFTNRDGVVKSELSFGVAFDSPASVDVPEFDFITPAGLPAHVTSSVLGMVDPLMRESSIKADVGYSEFHGRGQHRSWIVSITLDVLPLKKMLGFPARLYLRVVHMLERSLFLDNDELNGWFARLESEDDVTKIEASPVELDKDRNVGVARLRTLRTPFIDIEQHEMHCAPILYYGYVAVDGWAMSLDRLEVQYTLMTHTRYMHMNKGLTQELLRTPGVRALKSVTGWRYDLTFVNEPLVYVLDSPKVPSGIGSEVPATAMSYVEYLRGISFMKFVGRDIADADAPALANKTQWRRIYTTNHASGPSSESAVEVCKPKRTGLAFVGRVFSMGRCAGTRHRVLKIAEQQGYVVFSTPVGKYSNYNISVVATFIATVLVTIVSVALALRGSADLVVKEKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZP4</accession>
    <name>A0A061CZP4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766064.1">
        <property type="nucleotide sequence ID" value="XM_012910610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZP4"/>
    <dbReference type="GeneID" id="24562419"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102070"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="96" mass="10995" checksum="CAC22116B8972086" modified="2014-09-03" version="1">MLHAAYGEHKFKKHGIISPVFMHSGIVIFTKETRALIMETRLTRWTLTVMLLALSGVLLPMNDAMGRLSTEPQIYYEFALTITVNHLIYAKLVYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZQ5</accession>
    <name>A0A061CZQ5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766079.1">
        <property type="nucleotide sequence ID" value="XM_012910625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZQ5"/>
    <dbReference type="STRING" id="5866.A0A061CZQ5"/>
    <dbReference type="GeneID" id="24562434"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102220"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="185" mass="19082" checksum="FA8DEF969CF5E2D7" modified="2014-09-03" version="1">MADSSGGDQPTHRATTISISEGKEGNEGIYGTYEGSTKIEHKGANVGKMGSQAAVTRGILASQEAARRGILELHEAAARDILASEATVTSDILASEATVTSDILASHAAIRGVGKRVSRAAVISDILASQEAATRDILASHAAATRDILASQEAAIRDILALQEAAIRDILALQEAVTRGVLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZR1</accession>
    <name>A0A061CZR1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766084.1">
        <property type="nucleotide sequence ID" value="XM_012910630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZR1"/>
    <dbReference type="STRING" id="5866.A0A061CZR1"/>
    <dbReference type="GeneID" id="24562439"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102270"/>
    <dbReference type="OMA" id="LYIEGGW"/>
    <dbReference type="OrthoDB" id="440619at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050343">
        <property type="entry name" value="RsuA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683:SF2">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="238" mass="27054" checksum="58337A39525649D1" modified="2014-09-03" version="1">MRLKLSSFCAKNNICSKKEAKKLIQLGHLRLQGAVVREDTLVKESLSPACVSLPQRVQSIASNKVTVLLHKPECYLSTYSRRTQLWSKSLLVPENRCESDVQNNLNPSQLRRLLPINPLEYSTSGLALFSEDSSLIKRFADCEECYHVVFRDPFTEPKLFALTSEIYIDGVPIPQLKVDRVSDFSARVTTQSASSKLRKACRLAGLEIRSIKRIRLGNIHLGDLLCGRWMMLRKYQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D093</accession>
    <name>A0A061D093_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766274.1">
        <property type="nucleotide sequence ID" value="XM_012910820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D093"/>
    <dbReference type="GeneID" id="24562629"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103980"/>
    <dbReference type="OrthoDB" id="366389at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595627" evidence="3">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="181" mass="19929" checksum="C82436FEF3F04CDA" modified="2014-09-03" version="1">MRQWLGWVLSWAFLYSECSARAAGRRAFLAPALWSPYPVLPKTSTAWGSSARDQDSTVSSGWKGSRRGLTTLCARMKHEEPFAGSDSLLDKRSMFSNTALELTLEDMAAREADFERYKNSSLSHFRNIGAVVASVLTVGALYGALSMLRGMLNQQHANLRADRYGSLTPHSDVHTGDGGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0J8</accession>
    <name>A0A061D0J8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766502.1">
        <property type="nucleotide sequence ID" value="XM_012911048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0J8"/>
    <dbReference type="GeneID" id="24562857"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106250"/>
    <dbReference type="OrthoDB" id="359083at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056349">
        <property type="entry name" value="Microp_apicomplexa_10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23519">
        <property type="entry name" value="Microp_apicomplexa_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="134" mass="15624" checksum="35C481593FC95855" modified="2014-09-03" version="1">MLAQCCRLSRLRGGTPTPFWTTYVHSPGLRINVRYAYWPPPANKRSRLIELRVKLVDALIALYLLVLTSVQLPSGKKFFVFRGKRDADGKLEPVVCFIDRNGDRLTSLNSEELQQLQQLTQRIRTYFDLWQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0K5</accession>
    <name>A0A061D0K5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen synthase kinase-3 alpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0105020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766379.1">
        <property type="nucleotide sequence ID" value="XM_012910925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0K5"/>
    <dbReference type="STRING" id="5866.A0A061D0K5"/>
    <dbReference type="GeneID" id="24562734"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105020"/>
    <dbReference type="OMA" id="TIKCYIY"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="336" mass="37617" checksum="49FA6EE877670D09" modified="2014-09-03" version="1">MVGNPTYSAIKYSSPTQLILDPAELTLHKRIARGAFGSVYLATDLSGKTYAIKRTRKFGMKRSRELVNLGLCKDAENVMQYMGTFYTRNRSGIIMQNSLLEHIPYSLRSFIRVLKQKGGLAHCGVRRTAETPLQGKDCTLRHHESTDVMNGMIELHARGLVHRDLKPDNVLIDDDHLPTIAKICDLGSAKKINRLCLTNRSDMDLKQTPSTPYVCSRWYRAPELLFGNTFYTVCHESDARQVITLIDVLGSPSKAELKRLLDGAPSVSIRKQLGLLFLVKHSKGSLRMVLTDVAKGNTRLMAVASVAYNLLRWCPEDRISLEDARKILNAGCTRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Q8</accession>
    <name>A0A061D1Q8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0108810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766769.1">
        <property type="nucleotide sequence ID" value="XM_012911315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Q8"/>
    <dbReference type="STRING" id="5866.A0A061D1Q8"/>
    <dbReference type="GeneID" id="24563124"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108810"/>
    <dbReference type="OMA" id="IRWVQLL"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="742"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="934"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="919"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119514" checksum="285D5068A9AB0BB1" modified="2014-09-03" version="1">MTQNLNENWMKELAAGSTYASPYISDVLYDEIVAVPVVEAIECVLAGDLLRKWRRGQPLTTKKQGRGAKPQTQEAAENNASYLAVQPSSRSHERYFWVSCVCGTFFLRWDSWRKHPNETVFALCGLDTIRRGDEISSFDNKTKPDAKEKLVFVLSGAFSLRLAAATPRHALLWISGLYHIARHARDVYARAWIANSNKIATWFAAREPDGIPTFQSKTIEQELARKGNSLAELVAANKRSRGQEGKDMPSTVDEVVQKLTDLNIVKRSDVVEPVIAVVKDILATRESWLHKLIHGLIKSDYDDVDNLVRFVADCAYHLEAMDADIESSKKAIFVLDDYMSQDEVIKLMFDVVKHYSIVANVLGPEDYPDQRRPSRVARSLSNNTPQQNHGKSLNGSQAKKDNNAENGDNVCIGEGSGPLAKEKKKSNFLKGWQRFRRARDVDGLLDADSSAAVWASSGAPKRGNWMENEVDPLRPIENDQYQRFLQNVQGANGAETTENLLGIVEKDAKPPFTAAKFVETKYSQGCCMRAAPGQSIPVKMLTIMGFHWSLSQKFNTAAMPQDAEEIAHMLQYPLTSFWIASSHNTYLAGSQVGGAATAGALADALIRGCRCIELDCQDGANGEPMLCHSWKNCQLTGSITLREALLACKETAFSTSKLPVILSMQMTGSEECKAKTAQLCKEILGDNLYVPHPNDPVDHVASVPIGCLLSKFIIKGKMHTDPAVKNAKLDGEWMSVVALHGFRISEVTPDNISHAKRNDMYSMNEGKFAKISADSEFVIKLADISMLRVFPSGTRLSSTNFCPLNAWAAGVHCVAMNYQSCDRSMLINYGKFNQSFGYVLKPPELRPVTFRQDECTDYFCHKPIRLKIHVLSASQLSPPNEGLEQTNFANALGNVLYSIQQGGVEVDMDKVAAEIGKPRKNKRNVRRERREYWSPAEDSLKSDGADSSDTNNLIQRSSSIVASRADPCCPFVEVAVVGENERVQRTDIVSYNGFNPVWADTSPPFEFVVKRPNLSILLLTVKHYDNMGAQLIAQSALPINRIRPGIRWVQLLDQRFIEIDCCGLLLHIDIEYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1X7</accession>
    <name>A0A061D1X7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferredoxin--NADP(+) reductase</fullName>
            <ecNumber evidence="3">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0109360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 reduced [2Fe-2S]-[ferredoxin] + NADP(+) + H(+) = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766824.1">
        <property type="nucleotide sequence ID" value="XM_012911370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1X7"/>
    <dbReference type="STRING" id="5866.A0A061D1X7"/>
    <dbReference type="GeneID" id="24563179"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109360"/>
    <dbReference type="OMA" id="GKAWLFM"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015701">
        <property type="entry name" value="FNR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43314">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595887" description="ferredoxin--NADP(+) reductase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="302" mass="33480" checksum="446E63F8AB3E0E4A" modified="2014-09-03" version="1">MILVVWTCYLRVVVYSVKSPLECRISSVRYLGGNETDRSFHHIVIEHNGLYNFEPGQQVVSLDVHIPCLGISERTNRPHPPRSYSLAPVLDEDGVDPKTCFSLGIRAPVIPPGSAPLYRNICICSQFLSGAEPGTLIRITGPFGKFVLSPDDLQGKNNLLFIATGTGIVPYMGFLKSLLKTYAGGTQEFGSILLFFGIQSPSSLLYRSALDDYVERFKGRFAYIPCYSRFGDESERCYVQDKILKAQDVIRSMCCEGGRQCSIFVCGRKSMEKAVASSLQTVFAGIPQRDAILASMKVEVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D248</accession>
    <name>A0A061D248_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766378.1">
        <property type="nucleotide sequence ID" value="XM_012910924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D248"/>
    <dbReference type="GeneID" id="24562733"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600529" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="51" mass="5511" checksum="1D6934B9187F9656" modified="2014-09-03" version="1">MGFPTRCSRILLCLLLCVCCSAFSAQSLHNHILLAENTVVLSFLTDEPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D283</accession>
    <name>A0A061D283_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0200180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767047.1">
        <property type="nucleotide sequence ID" value="XM_012911593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D283"/>
    <dbReference type="STRING" id="5866.A0A061D283"/>
    <dbReference type="GeneID" id="24563402"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200180"/>
    <dbReference type="OMA" id="QAYDLEY"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="20917" checksum="18C98AEE1B343818" modified="2014-09-03" version="1">MASNTFKLVEEDFKCYYDFKPGIRFIDMMPVMGDARKLRETVKSMAAGIRERHPEGVDYIAAMELLGVPFGAPLAYELGCGLVVIRKPGKLPGPVYTTHSKKVYDETDLHLQKDAFPEGAKVILVDDLIYNGGTLAAACRLLQMGGAKILECDVIVDLPFLNGRETIQKEFPGVNVYGVMEFSPPKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2C0</accession>
    <name>A0A061D2C0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase assembly factor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767092.1">
        <property type="nucleotide sequence ID" value="XM_012911638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2C0"/>
    <dbReference type="GeneID" id="24563447"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200630"/>
    <dbReference type="OMA" id="FEECLHN"/>
    <dbReference type="OrthoDB" id="340921at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9950" checksum="A934C2CB739F8769" modified="2014-09-03" version="1">MALRLDPDLPHRHASNSCDALQNDMVECYKASRCCRELNRPFDECLRNRRPDEVGQECLLLKRALAQCRRNVLNGKFRVTGNPYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2T5</accession>
    <name>A0A061D2T5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767272.1">
        <property type="nucleotide sequence ID" value="XM_012911818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2T5"/>
    <dbReference type="GeneID" id="24563627"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202430"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="6538" checksum="48D0ACDACE19F902" modified="2014-09-03" version="1">MQLMQKLVAKTRLILSDAATAASELNEDRLVLSRFYGLFRGLLLDCVKNSADVKDPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3A4</accession>
    <name>A0A061D3A4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0108650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766753.1">
        <property type="nucleotide sequence ID" value="XM_012911299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3A4"/>
    <dbReference type="STRING" id="5866.A0A061D3A4"/>
    <dbReference type="GeneID" id="24563108"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108650"/>
    <dbReference type="OMA" id="PLDFCEI"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="265"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="780" mass="88796" checksum="C8E515ACD3A56529" modified="2014-09-03" version="1">MSESRDVIRKLHPKVIARIAAGEVVVRPAAAIKEIIENSIDAGATTIKLRIAANPLHYAEISDNGCGVSPNDLKVICRRFTTSKTYEDINGVKSFGFRGEALAALSHSANVTISARTSADEKRTVVRYHDGEPIDETASQMVGPVGFTITYENLFFNMNTRGKTLSASPSVEFNLCLELAQKYAVHYPHLEFVFHKVGSSTLELNTQGSDRATDGRGAVHDFDHRHFKEVSLFPPDAVDTPELVHYREHVEERSKQDLVRVRSAIKEVYGSVVANSLYEFQTHSTGDVYYNCKGFFTHPNQPNRCHSFILFINNRLVDHPTLRRNIDCVYKELLHKKQRRFVYLAVYMPYDRIDANVHPSKEKIFFKHQEQIVEEIGERLREQIRGILKINTENAQKASAYNQMEVTTRQDDVDESIFPHLKRTYETFEKAKPHAKVRVRSDYKQMDIQSFVTPTYIMESNADLDSYAHQAVKDPKAEDTEADTPGSESTAPHTQHDENAISLAALPRLANTEFSLMDITGEEDGFSDMWKIPFIKEFINEFESTRDRKLTDTVLNSVLVGVADKHYVILQHSTELYMVDIIRVAKECVFQSVIWRIGQLPKLFLNPPLCLVDLLSYALARDAYQARGSAGEIDKSQFLDKAKEMIRKFHVGFLTKYFGFSIEDNKLHSIPKVMSNYFPGPEYLPGLVLALFSLDIVDEGKAVGDISHIISEFFTFPPIHSITTTDPVANEKNYHHYISKVLLRAVQRFPDLSLSRRRLDRGTVIKLASLDLLYRIFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3A8</accession>
    <name>A0A061D3A8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0108700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766758.1">
        <property type="nucleotide sequence ID" value="XM_012911304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3A8"/>
    <dbReference type="STRING" id="5866.A0A061D3A8"/>
    <dbReference type="GeneID" id="24563113"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108700"/>
    <dbReference type="OMA" id="NDFIHEG"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="601" mass="65831" checksum="A67BE099AEF9C76A" modified="2014-09-03" version="1">MRQAATEPLTSLAFSPSPSMSSLIALALLLCPILASWSFRIVSHKRHWSNVRDFRAATRVDQGGQDARIEHPESVFSLQGKTVSSPFLAELIDRGVVAQATDLSKLDELLCLHESAPEAASGQVPAIYYGIDLTADFIHEGTLLQLLLLRRFLAHGLNVVIVLGGGTTPVGDPSFKTKRTKATIAATCGDRVSNNAILGSVATCPSVSKENYDGILNAVKKLLTREIVTDGGDRLCPSLSFASQMGEADIARMRSSRHNVVVVNNRDLYDSVTLTEFLNTVARNMSVGRMLSRESIKSRLVLDDGRGGFPLRKANMDLGEFMYMALQAADFVHVASKFNAVIQLGGSDQMGNIMSGVDLASSLSELSKPLLGVTTPLLQTRKGEKVSKSSAECLLAITAETPALTLWSHFRNVDDEVVHDYLRWLTQVPLATINDTLATHVNQAKVWHNSRSYNLTAAIYGDQYKEALHKHWLSGDMAETQQSTDGCDPAEYDSFVRFASCVPRVFLKAGELETGVPFGDLLDRVRTPQLTSGLFYSNRRAIREGTCRINGKVETRVDRLITNDDLLHLSSTDGRVMKYVALQFGKRQLHLAVLEPSHTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3F5</accession>
    <name>A0A061D3F5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766798.1">
        <property type="nucleotide sequence ID" value="XM_012911344.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D3F5"/>
    <dbReference type="GeneID" id="24563153"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109100"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1590" mass="177303" checksum="AB794EC3DE93E525" modified="2014-09-03" version="1">MAAKRTSSVTEHGVKLETLKDCLQFLEWLRDTKRSGARTQLAGRLARLLNNKYNNVDRQRIEDALFQFLNEVSKFHHKLCKKADQGTHKPQTTKPALNALLECIPKVLAVMYYLRYHVDKGFAAMGGGDWADDMIGQVEMLARVMPSGSLMKHATNIEKYLITANGDKYGVIPGGFEPSDLKPNTGGGYSVGSAMAADLGNLLDKNRYKENLFLDVYSTTVVGNKGTDTPNIANALRLVRDFCRIFAEVEDEDDFKSHLYTKDKCIKYNQLKSHCAQLKDPLEKIFKGERFSFTGYGRLFKDLNKQNIAKKMASWFRTNLDDVLSKLTLIKSISSLKGINSRSFQKGKISSVEHAKALANYFNENFFRYGFTFYGHDFNKWSNTYEVLKTDWDGVIGVMKDKSEGLEELVQILNGEVCKLQDREETQKGKEQGTEDKNEDEKDEDEESEDEEDAPLDDKDSPPVKTEATKTEAAKPTAPKVDGTPNQGKKAEGAQNQGKKAEGDPPASSPSSKPTQPSSSTGSDSRSSGAGGPRSVQDLSVQRSPGATQTSGQEDETGKAASTRTPIGPSSDTGAGVKPNAGESTDHNSGKKSTTPQCEAGQTLTDSWKGGNKICISEERLKKAKYWESAWTKANEAKNEEEAEERKEKAAYEQYKLQMNQMTNYPLSLDGYDLKSPLDGAALPDDSTTQNRQKLDANFKIAYEKILQNQTRADDNMNNKIFQSEQRGEADEQAWIKREHNQDISFHGFKVKPSRHGSPIPTPSGLTGQVVSDASKNERSNHDDAVNQYGQQWKQSEERILSADGSHISPPLEGKALPDISDLLLHKQNEAEDKWAELNSGPFVQNAKYDEVFGNKFPKKKRTLHSQLTPFLTGNYVPDELRAYRLNENIEKAKDALKRIYARNEYQRRKSEFIGSPTADSQGIQKSRPLQFLAYNDIPMGYPIKPPKLPNTSSLVPDVVGLTVDAVPNDKFVRQPPLTGEPTVSPPKSTEHDPPIPTQLDPGFNNISIGGSEAIAQSVTTDYIQSALVDSDLSVFEPIKTTNLTAQHDHVVTKLPITVTLDDNITATMASVAGQPAASLDGKKATHYDYNKRQMDAEIHYENQKLQHQHGQRQRELQALNEESIKTIGEQEMLRTAAKIEADRIHTFKASKFDISHRVPPISLEITEPPTDDSDDFKDETFDQLDPVHDSQVYMDPYYNVTDDQFEITTVERSNDQSYNVDFTPADVSFDFAHNDVLATPTFTPLPPDTSLQITKPPKDDKAYIVNQDTYEAASQPLFIDIYKHTLDDPSYELNIDDPPLPPKLQPVDPIVPSTPAINLNIEPFDVAPISIPEDFDPQIINRPELKMCLAPWATQTSTPGSTDIPETELFPSQAPRTVRDMLQWLAGLKNEKHHKTLKQCIKKAFTGSHKDTSQLALSINHNNILPDHVLDILQLTAMFAGSVLTSIAPNWRASVASRTVKPMSNQSDEPDCCALLCQLRDYAYACHHQLTFLKAQCKRDKLSGGWMGCQYGSDVKTSSPLQAFLTDRWDSTFKTHLFDPCNPCLKIRVKMGFRMEDLPNDSPTGNTLSTILTPSCGGEDHDALLRTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3H8</accession>
    <name>A0A061D3H8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766818.1">
        <property type="nucleotide sequence ID" value="XM_012911364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3H8"/>
    <dbReference type="GeneID" id="24563173"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109300"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7818" checksum="23DCBB961242FCE9" modified="2014-09-03" version="1">MEDQENESRETNKCCKSDGNTFSNTPHLTKSAQFWTTYQKVKSNLVLFYYANDLRSHHQLAPYVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3I9</accession>
    <name>A0A061D3I9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HECT/ubiquitin-transferase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0109400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766828.1">
        <property type="nucleotide sequence ID" value="XM_012911374.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D3I9"/>
    <dbReference type="GeneID" id="24563183"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109400"/>
    <dbReference type="OMA" id="FLWFANG"/>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042469">
        <property type="entry name" value="HECTD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="3663"/>
            <end position="3696"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="4389"/>
            <end position="4820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2370"/>
            <end position="2462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2426"/>
            <end position="2441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2451"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="4788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="4833" mass="537719" checksum="0B9D96A1996CC47F" modified="2014-09-03" version="1">[encoded data, 4833 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3L7</accession>
    <name>A0A061D3L7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767364.1">
        <property type="nucleotide sequence ID" value="XM_012911910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3L7"/>
    <dbReference type="GeneID" id="24563719"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203350"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9088" checksum="004A730D5ECBD775" modified="2014-09-03" version="1">MGEIICHAIAAIVGANLGTSLRRTNRCMRRNEAQIIQIRHLGNPSPPQDSVPRMNDCSTELQYTGSLYIKVVKYVPYSTDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Q6</accession>
    <name>A0A061D3Q6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767517.1">
        <property type="nucleotide sequence ID" value="XM_012912063.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D3Q6"/>
    <dbReference type="GeneID" id="24563872"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204890"/>
    <dbReference type="OMA" id="WIRWQGQ"/>
    <dbReference type="OrthoDB" id="366416at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1800" mass="201396" checksum="99C4E5B5953AD69F" modified="2014-09-03" version="1">MFDKYVVGSLYQVSCFLLGLSATLFSSFINFDAYVLLRFLGVSAFEAQAVWYFVKRFNLFIGIFVTVLILAFGTASRRTVCKWSWILFSLFLSVGLYVYYYQDCGARFTPLLEWILLSISFASNVLQCLSIFFVFDQGAPVGSGKPQFRLLLYLLGACTSGLILRFFLNINWNAAASDVALAKYMVFLINRVVVALCVVTFLSALITSGVVAYQWQGADVEYITLSLGSAATFLFHYECWGVLFCTAMGWAITPFCGILTSFVAIKTSLAVNANALTLQLAVFLIETILALVIVRLRYRRYVDPTVCDIDELKRALCSNTKTCESRATNNDNSSAGKEENDALSGSVYNRLLRNAQPWILLPSGYWSEWYKADCDDNRMMLQYASALVKLKRAKSIPKTNCDVISDCVPCDTDTLYDRYQLVLEVKSELCWLLTCFVSKNADLQVNLDKTFHNTPREVMAGCIFNTLVSQWTEYLCCNVDDLKYDCNFCVNMDGYLLQSSKQYMKGTLNCCLEDATELRNEIGRSSLFCKYECELTEDDIHEAVLKLECTFSDFLRLLLMAQLADEWILLCKYMEKMKRGLIKFLDHCKSANTEADQETKNRGASTQTRRSNNVISQTTAVAASGKTTQSDAQKKCEGKCGCELFSKLLRCICKLHKLQCDTASRMRNFSLESLKDKLPTLCHTRATYLIAKSFAGFTRCANNCSCNKPPNVKMWVCDRFSSQLDELLTLLTEDFELLLNGDKLLCMAISIVSCLQTDELIIPISTLEQIDQSATFLSDLIRRTSAFGLKLMDYVPLDLGFKYTKQHCECKVGSVIQKNGCCSSHKCTDPKCICILCTRTTNADGKDDCCFSMKDCTCSTGSSVSQNVNTDECTKDCCCDNTKCHGYTCGLESCLCGNTRIEDSTVAGDTPLTDLVCGVSCLMKGLCICLGAFTKSTFCRNSRDGGTSGCNHSVISNVCSFPTFVESLTKCTSSSGVGSQSCCSAVNNDCVNNLTCDVLKSIFKATKGADVGENCNTIGDTNCIGCCLSKYSSEKIKTCTNNGCCHNIKEICGKVKETSSTMQQIHEEVSHICKSVNEIRSFALCITTTVTIIKACYNCIKKSLVRLVNCATKRGSQLQAYMESLIKMWKTNTRLLRSSSANIQRRCNVLEAKTRAYSSALDNQVNGLSRTSESMSSIGDYALDLHDRASQATQVIATTRRSLYMDSVRSFLCNLLCTEKSKNCSNTSSCIDVFECSFYGVIACAMFLHIAGIEILPAIRFLREITLYRIFLMACALMAPIMVLKGFVKISKIPQQAGYLVNATVLIGTICSILLSWFSQGYGFRSYLTNQFSVYSKTYHQMYADYVDEPLGNVSWWSDGFRGMMRADLKAVSDFCTVRGVVYNMDPYNLGFSPVFVLNREKCPDISRSWTESHVTYHIKNVVLEGPNDDYDKFFDFLALSTMSKKNWNFLTDAIRDDDASYPIDMLWEAWTTGKRVTKGHHALYKIRLRALDTVSKEIESSFRNMGKNVMLFEKSLRMYRQQVLAEVAAKCLDLPFVPEPPRFSAQHTGVVKLFEEQYKAHWEEYTAKEAENTKNKSCKKGTVSSTDTSKGEPFLTKAKKGLSQMKQNIIGSFSRLTAKNKDMSDSKHGDSEGNDITLSLMKNQCRSWAANKTALCNESYMGDDRCLNMVNVVVNRFKSFLKSREKGTVYGSASEVYEAYETFHSSRDYETTVLIFKPSSNSRRTKSCAIPNSLWRWQRGADACYLGALNSVRSLAKLEDEVQAAKSERLHHILGEWLRLSGVNINNGAVSLMSISSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3T0</accession>
    <name>A0A061D3T0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767419.1">
        <property type="nucleotide sequence ID" value="XM_012911965.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D3T0"/>
    <dbReference type="GeneID" id="24563774"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203910"/>
    <dbReference type="OMA" id="FICECAG"/>
    <dbReference type="OrthoDB" id="365311at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1388" mass="153579" checksum="674FD9021DB6F143" modified="2014-09-03" version="1">MAGPRTFSLARPSEITISAGSDDDSDDEDYCDTAVSRGRRAQRAPQMRVREAHSEVPVTSRLFEIVIMRKHAKLSTCLQRLLLTMSTAERHVAIADILSFICECAGFKHSSISSEVVQAHDLCSGVASRKSSFSAMESDRRRRDYAPIIMEMSSPGGMKDMDISPDGLSEPYYSVMDGSVGRRPSSHAGGASPICDPHDPLSANHSPTHAFAGADPCESGFYDDDRDVRLTYDSFSWWSFREMFTSLPSGANYSDIVRHCSSQCTSHAIEPDTLFFPKNSDLFSDRRSRCLSRKFYQLCVERVAPLTRALDAQDGWVIGFGKHNWAYMLFKEFFQQLVLEAEAVCVGELLHALQWICALSMIGFRAVRQFALIACNDVVSSLLVKLNSLAKNERVFAKQLQVEIDMDQRTHERVHGRDSRVRVTVSKSSLELYKKLLLAQRGQRAILSFLKCLYDVNFASKMQDVLVDIRVSAAFSLGNNVLLNPQIFSSPAYVDFTYRLLPATDECTRLLLLRYLGLVERRLGEEEFGILLSLHESCVNSGLADSCEAIEALLLRDVHFNYDRSAVFSHRSEKLFLRLVESLSKNKNSTLGVLIASVFLPSVPIHGFSLVFQIRTDGLRSKYRNMLVPHPAVVGRQTKLVISDESTSKVRNFYQCFMELSRLAACIAATEAFVTNLVGSLWNHNHLFEDVAGIVRFLCQGGDVASVKARLDANCQQLLLHITLASFDHLLADATAFTEQQLEAVGTVISYAPVFLRLYRANASHMKTALQLLEQATALLHRTGLPLDGGLVNAVADVLKYLVDSDNGDEQTIDSIRLAVRCLYNVYAHSEEAKLNVASLYRVLSKQLSSESESGKNLLHCVMNLLHFFPLELDVPGILIPLIIKNLRAQAADERMLWCTIGYVLFEAELYRCVKTSQPSVDGAFGELRDVLLQSIAAVAHDSSSDFTLFVCFHSMASLVQISALAGGLEEVPHESELEMYRILLHFLQLVKPSHMRNAAAPPPGAAKGYTIADVYVAGYCESYFTMNPLDCVLSIVTLFTKVLSARLYCSGVSVLVLLQTISLCAPIAAAAEVYLRFLANFDDQILISLLLFAMIGLYESGARDCCAELRHRFVDTLMGKGAKTAVDRKKLSINALLLSGMRYALQGPSNWDFITELVELTKTFRSYEGHVNSTLLHAQVGALLTPIDVPEELRAKIFEFLQVVGLGSAITMRAMAGCQDIDGIDRCLNIIRRKCSHVDLVSLTGGAVARKERHQPSSTCIVTRQRPVKSIDRLVSSETRATSAGSPESHLDVSPIVVRTFTKSSVRALPPSVGMMRPRSTPGTKLDVDDDDVAESVEVEPDVLSESGEYQVSTATPITERSYGMRSTPSFGLLSPTSPLLSPIMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3V1</accession>
    <name>A0A061D3V1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">200 kDa antigen p200, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767577.1">
        <property type="nucleotide sequence ID" value="XM_012912123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3V1"/>
    <dbReference type="STRING" id="5866.A0A061D3V1"/>
    <dbReference type="GeneID" id="24563932"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205490"/>
    <dbReference type="OMA" id="YELKWAG"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595423" evidence="2">
        <location>
            <begin position="33"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1113" mass="133187" checksum="DA2C5219E4DF1F29" modified="2014-09-03" version="1">MAQVPSLRFLRNARGFFVLALIQCLIANTASAYHAGSSAQRNLYKNDFLSTQHPTASFLALGSRSSSRSHTPIFLEDADTTFSTISVQPSSMNVQSVLSRYNRQALEELKAQPTDKCSEWEPLTNCSTKQALHCMKPLDTSITMLCFNDTCGTWSPWTICNNQLQYRFRPECAGDSIQYRECSGNNYAIFKIEEAKRLAKEKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAREKAEREQREREKAEREAREKAEREQREREKAERLAREKAEREAREKAEREQREREKAEREAREKAEREQREREKAERLAREKAEREAREKAEREQREREKAEREAREKAEREQREREKAEREAREKAEREQREREKAERLAREKAEREQREREKAEREAREKAEREQREREKAEREAREKAEREQREREKAERLAREKAEREQREREKAEREAREKAEREQREREKAERLAREKAEREAREKAEREQREREKAEREAREKAEREQREREKAERLAREKAEREAREKAEREQREREKAERLAREKAEREQREREKAERLAREKAEREAREKAEREQREREKAEREAREKAEREQREREKAEREAREKAEREQREREKAERLAREKAEREQREREKAEREAREKAEREQREREKAERLAREKAEREAREKAEREQREREKAEREAREKAEREQREREKAERLAREKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAKEKAEREAREKEEAERLAREQEEREAREKEEAERLAREQEEREAREKEEAERLAQEQAEREAEEARRLAQEQADREALEKEEAERLAREQEEREAREKEEAERLAQEQAEREAREAEEADRLAREQAEREAEEARRLAQEQEEREAREAEEADRRAREQAEREAEEARQKEAERLEHEQEEPEAREQQDGESMSPEEARPTPYTMVRELNEEASLEDEEKQEHEQKDSEYDEKQSENNSKYSTISMVKHASVGLAAVVSAVVGSYVYSKGPSAAAGLASGVAEQGFDDGAYGARKEDDIETKIQLEENFWAEGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D440</accession>
    <name>A0A061D440_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767514.1">
        <property type="nucleotide sequence ID" value="XM_012912060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D440"/>
    <dbReference type="STRING" id="5866.A0A061D440"/>
    <dbReference type="GeneID" id="24563869"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204860"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="79" mass="9230" checksum="3CB7232021A0E3A5" modified="2014-09-03" version="1">MPGLNPKHGSRLLGVACVGLLASPYIYNAVKQAYWTRRYKKLNMEEIVSDRFTWLHHCMLRDEIERTLLKQEQAAVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Q0</accession>
    <name>A0A061D4Q0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0208400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767872.1">
        <property type="nucleotide sequence ID" value="XM_012912418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Q0"/>
    <dbReference type="STRING" id="5866.A0A061D4Q0"/>
    <dbReference type="GeneID" id="24564227"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208400"/>
    <dbReference type="OMA" id="VALWKLC"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="417" mass="45598" checksum="E2ECBE1303353B75" modified="2014-09-03" version="1">MEDDSYAEEVASILQLVGDEFNTVEYFDIVERHAIVIYNISGHSDFGVRFNLPELALALGNAVYVPQEFNCVRVDVRVRSSLEASTRSDNSSGFPGIEHVPVLEADRIYDTQAVLARRFPHNDPALLTRRIIQGDHCSIKISIFTNGRVSFTGGRSLLSVAVALWKLCRVIRQRVNSKAVVRMLSPTNMMAVYRFPSAIVLQAFEKHAKGCIYDPFRFSGVRLRVPVKPWNNHYDIRTVILEGLGKRMPAAEPAYPVSAAPDSSDSDEFDAASELSSSMPAFVQPTAAPAAAPRADPPVAAPPIASTGMAAPRQRQLKGNLRRIISEALPSNKRQVVDSSAKLQKTVDTGAGKRVWSTSTTISDPDTVYGREEVVTLNVFTSGNVTLTGARSVASLQYALSYIYPALKASTVKNVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4T1</accession>
    <name>A0A061D4T1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767897.1">
        <property type="nucleotide sequence ID" value="XM_012912443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4T1"/>
    <dbReference type="GeneID" id="24564252"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208650"/>
    <dbReference type="OrthoDB" id="10364633at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28425" checksum="F517B7E7E952BC21" modified="2014-09-03" version="1">MAYNWLTDVPRNFKEAIDWLIALKGTDGVNNLKAMGTAIHAILANKPAGFTKVPALEDVKLITKEFLEKDNIKDLSPASDMLQRFSKPMIKSNSYAKKFNFEESDYVNVISTRAMKPEDIAHDITELVYGCAKFLEEIKTPDKYNSAYSPETNWEASCARNPQACAVVFVGIAPMLFVGLRSLQFASYSDGFNWLRFNRMKVSMVDVLEAMGYKKSELPLIKNGSNVFNALKNVSSRMLSTLYDLSGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4W1</accession>
    <name>A0A061D4W1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766180.1">
        <property type="nucleotide sequence ID" value="XM_012910726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4W1"/>
    <dbReference type="GeneID" id="24562535"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103150"/>
    <dbReference type="OMA" id="KQTYYHR"/>
    <dbReference type="OrthoDB" id="366335at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="30361" checksum="032CE99C119C8036" modified="2014-09-03" version="1">MVASRAFASVADAAARPVWKLKQTYYHRLWRALSNHKWSEFERLMREMRLKRLSLDEVTYTLKAHHCILNPHKPSLSCYLVLEEMKQALIHPAVIRMNEHLINSYFELEEIKCQPPSQLWQNFAKATWQTSFRLNRHRMKKLREDLERMDPEALLKLDGQAVATLAQDEFLQAVFSPTLAIDEIHDEPIAAHAATQGAIGAPPAGEMDDDDSVLDGTADSMLGEGAAEQYFADALQHGNHEGDVDNDCDIESEISQQSDSGSSPRQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Y4</accession>
    <name>A0A061D4Y4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal subunit protein L14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0202640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767293.1">
        <property type="nucleotide sequence ID" value="XM_012911839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Y4"/>
    <dbReference type="STRING" id="5866.A0A061D4Y4"/>
    <dbReference type="GeneID" id="24563648"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202640"/>
    <dbReference type="OMA" id="ETRHNCK"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="123" mass="13622" checksum="026184E129D3D050" modified="2014-09-03" version="1">MFLSAVLSGLQKMSILRCGDTSGIVKGCIIGLGRTRHGTGKIGDRIKVSVRDKTADCTISNKKPRGIIIRRKKETVRRDGMVFKFDENAFAVIANNKLVALKIRGPVLLETRHACRNLANRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5C7</accession>
    <name>A0A061D5C7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768087.1">
        <property type="nucleotide sequence ID" value="XM_012912633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5C7"/>
    <dbReference type="GeneID" id="24564442"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210540"/>
    <dbReference type="OMA" id="NYLQPCE"/>
    <dbReference type="OrthoDB" id="366115at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="127" mass="13971" checksum="CEFC2836642BFB54" modified="2014-09-03" version="1">MQKPRFDLSDLSIPSSLKKCKEFLPQLLESNATLARKISEGDSSHVLDAEMHVYRGSHSPDHVTDEQEEGKIVLDVGVGVFDVNSMQTDDESLKASGVTTVTLDPRSEVFRTDEPLITEVERPGNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5D9</accession>
    <name>A0A061D5D9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766370.1">
        <property type="nucleotide sequence ID" value="XM_012910916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5D9"/>
    <dbReference type="GeneID" id="24562725"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104930"/>
    <dbReference type="OMA" id="FENNNME"/>
    <dbReference type="OrthoDB" id="364978at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="387" mass="42564" checksum="417598459B6A55E3" modified="2014-09-03" version="1">MKLQMCKSRRRMKEAVSAASHPAGEIVVDESETELVNGELTKETPARSAELSTGNSPFSSGDPSVHAEVIAADSKENDAPELNGDDHEVNHDSEYADNGVQAIEAYDGGESYLDGVGVASIDDRRSFTQDFSQMQDYCNERLYELMTNQEVALKCVREIVPSLAQSCLVASTECQSCQPIVSGCLGLGDSSSVTEMENNEFRVVEDHGSLDAPTIPTGIWVVDTINQALDKWSDSEHLGAMGSLFKLLNLSALLTYLGDTSGDRVVALLTRTSSVITRGPEAWREILRCITTESISEPKSMPVVPNASFVSRCEANLDDVPDMDQLADGPFKAYWTYTERWMRMHFSPSVGAPRDFTDQAREWFNSLDTSAQELFTRLSRTLCCRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5P6</accession>
    <name>A0A061D5P6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768232.1">
        <property type="nucleotide sequence ID" value="XM_012912778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5P6"/>
    <dbReference type="GeneID" id="24564587"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211880"/>
    <dbReference type="OMA" id="NIFVPNC"/>
    <dbReference type="OrthoDB" id="360261at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="293" mass="33130" checksum="72183C32AD6B17F3" modified="2014-09-03" version="1">MATDDPEDAYAQFMFSEHQTATTLPDSATSGTPTPAPASNSKYEYDIRDNEKSRILRLIVRLLLHRAPFVTRYDEIRAVVKTYLHDHANHAIVNCFIGEYDASLQFQYGAEDAKKLVSKTLGLILCDIKLQGARREFFLKQSLAFQPHDLKLLGDGDHELRGFLLLLLPCFKAYTTGIPLGMFTRVGKADMVPRDQASEEALKAALRGTRRKRAVKYSASEFSNIADYLLYARELGYLSLVTDPKKGDTLAVITVMPGYRLLFELDQESYVKQLSTLELDEGLKRTLEAFFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5U7</accession>
    <name>A0A061D5U7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-type ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0105980</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766475.1">
        <property type="nucleotide sequence ID" value="XM_012911021.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D5U7"/>
    <dbReference type="GeneID" id="24562830"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105980"/>
    <dbReference type="OMA" id="MPEWGYL"/>
    <dbReference type="OrthoDB" id="289856at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF11">
        <property type="entry name" value="CATION-TRANSPORTING P-TYPE ATPASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600629" evidence="13">
        <location>
            <begin position="21"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1149"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1223"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1272"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1305"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="489"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1420" mass="157426" checksum="040A147AAFE77E60" modified="2014-09-03" version="1">MMYPVAGWTLVLLCSAAVLCAERKDGILLKDSTAYKQDSTIDAPVYAHQPTFSMYGHRKNSSKSQMLRSSAQLHGAAYHGSSTAAISLNEEKEPKPHVKGNETVTPSESQADPGDDKPPKKDEPQRNSRWCQSNTVFLSASELTTFNLFALSLLSVLMVWHIILAVRSRDMNGGYEVLGEASPSTVVDPEEYKGSLNQEGYSHTAPGKYLIKCMLMYTAICQVAVLALTCNEMCIPLVDGIAHWEMRAKPFVVSWFVGFFTLFIYFVVRNTSIGKRMFMVPAPLRSCEYVLIIDNANTSNPSEQDVLRSVVDWCCSVAAFMKLNLNIPDSVLKVTLDKYKDAAAHVYVKVIEAENERYFHYQCVKYTYNSELGIFVDASAQVSAYLRNTNLTDLLDKGGLTEAESFRRTLTIGQNIIPVESLSFSMLLYREISDPVFFLQLYLTIKSIYWKSIITAPIWGFMVLYTIVKKVKIINDQQNDLHRLATAASNTTVTVLRENMTKTVHASDLAVGDIVRVQSNWEVPSDMVMLRGDVIVDESSITGESIPLRKCRLSVDQYGYSLSTFDFNLSIDGSGKRQLAQKGVTEHLLKAGTRIIAVVGNEEIAASAVAVVIATGVYTTKGKQMKGVLFPNQFRLKYDTQLPMVFILTFIYALVCSSYQIRFLGWNMISLFYCLGTLSQVAPVWASAVMSIGQSRACERLAKSDSICCIAPSRIAIFGKLRVMCFDKTGTLTNNSLVFDGLMMISRNKRQTVSLSPADVKGSINGIKNTVQLATRKDEDTKRQILTLAMATCHSLFPHDGDSEHLGNQVDKSMFHATGCLVEQFIDSDGNTRRYIRCPSNRDLVLEVLRTFDFHYQKKLSSIVVSVKSKDSDKGSIFVFVKGAYENVVACSTGSFVELDRLAKAQSESGSYVLGIGYKIISEDEIIAKRESIESKLTMGGLLVFNNSVREESASVVAKLQEAKVRPVILTGDNVPASQFVAKSLGMFGDGGSPGPNAELIDDNLVWHFPHNAIDEETLYFGTDCDNLSITGDAFDRIDEDWESILKVYDRWTTNKTANENLFEQFLLRVRIFARLNPHQKVRVINAFKRLGIITGMCGDGTNDCLALQASHAGVSLTNGTASMVAPFTSKNNTLQSVITLIREGRGSLVTSLACFKFMLLFGLMIALVKVFLFKTCRGVMPEWGYLLLENAILLSLSHTMALSRPNDKLRIRSPTSSLLGPLSLSSIGLMFGTNIIFLILLFKLYAYTGSLEYNSKMNVASWWMLSDNFEAPTVCLWLCYQVANAALVFSFGGIFRESVFRNTYFTLTWLGINGILTLLLFSGPSRLTCLFRINCTDEVSRQTVFPVLRVLTTSANGHPFSGQGGHNVLSTKFRVLFLALNVANAVVNGLISKFLLGSESLKAMSSLIGHKYSADRINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D654</accession>
    <name>A0A061D654_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767683.1">
        <property type="nucleotide sequence ID" value="XM_012912229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D654"/>
    <dbReference type="GeneID" id="24564038"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206550"/>
    <dbReference type="OrthoDB" id="366620at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="27719" checksum="6CC1E2C56CF599D6" modified="2014-09-03" version="1">MVYTSLTEVPRNLKEGIDWLLAVKGDDAEKNLKAMSTAIHFFLRSQPTGSTKLPALEKVKYASELFLRRQEFRDKPLVKELLKRFAGTKTKNPTKLAAILENVEECDYKNVVQAFGLTPKNITKKLGRFVGGAEKFLDDLKIPGQYESAYSSEATWDSSCAKDPEACAVVFVGIAPMLYAGLRSLKEEGGPAPVGEAPNEEKRNVADALKAVGYGEGCRGGLSRLDLQKTTNPVDSQALDVIFDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D688</accession>
    <name>A0A061D688_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0212150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768259.1">
        <property type="nucleotide sequence ID" value="XM_012912805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D688"/>
    <dbReference type="GeneID" id="24564614"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212150"/>
    <dbReference type="OMA" id="PFITVVR"/>
    <dbReference type="OrthoDB" id="365127at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="184" mass="20923" checksum="81F005101F8A3246" modified="2014-09-03" version="1">MGDCKERCFSSVTDTVNCLFSSCIPTVEREEAPSSYTGLHDTAYRKEELKQLVGIFASRAQRYLACTRVDIAKGEFKKARYKMDCRLRTLRVESDEAPVEISLSKVKAVYGYEDLQLLDSYESFLNQEIIQNLGSEERDRLSVIVYTTESGADAQLVLMEHEIETSDAFITVLRILQMHAQGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6D4</accession>
    <name>A0A061D6D4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0207325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767763.1">
        <property type="nucleotide sequence ID" value="XM_012912309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6D4"/>
    <dbReference type="STRING" id="5866.A0A061D6D4"/>
    <dbReference type="GeneID" id="24564118"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207325"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207325"/>
    <dbReference type="OMA" id="PCEERLQ"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="4">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="188" mass="21518" checksum="382056EB08465BA7" modified="2014-09-03" version="1">MVGVTFLAGLIRAPESQIAEALGRVGAEMWQGPRGNEIAMANSRFSIRKLVGDGLIIKKAVAPHSRARIRLIHASKRLGRHSGIGKRKGTKGARQPAKLLWMRRQRVLRRMLRKLRDSKKMDSHMYQNFYMRCKGNQFKNKRVLLEAIHAQKNSWVKQKAENEQIEALKAKAKAIKEKRKLRMAARTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6S5</accession>
    <name>A0A061D6S5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768582.1">
        <property type="nucleotide sequence ID" value="XM_012913128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6S5"/>
    <dbReference type="STRING" id="5866.A0A061D6S5"/>
    <dbReference type="GeneID" id="24564937"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303000"/>
    <dbReference type="OMA" id="HFLWTRI"/>
    <dbReference type="OrthoDB" id="286820at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="887"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132281" checksum="C70524CECA813F1E" modified="2014-09-03" version="1">MWREHRVAWLSGERSALFSSTSHAQSLPTRQQNLLYKMEAREDRQPGLWRRTAFDSSKTEPPTSFLSPQPARAYPRMIELSYKPTPRKTEPASYGTPNHVSTTSRIPKWISRYTDQSPSTSKVVTASYAEPKPTTPNAVIPNDVKAVPANPLAPTRRSKPVVSYIDVGLNGQNGGTTPNKSDFVGVHKDPEEPPKGILHATRFFEPDVDKKGVDEAKYRVPTEPTVPKEHQDALAITMGGANDSTLTVQLVDEIEPHAFSKVTNKWGAVTHETTADDGATSDPLATLRDLEVPLNSSLGYSGDENVVETARTPIKHISTVIGNPFTIFRLKHARSAVNVTEEDLAALKATMFAKRHSPDDLLSCFKASISVTNIPMMDIILRFLCDVMRSDVSQRELCVRMMETALVYHPDELVRCFSCTYIPFMFDPELNDDVGGSFMRLLLSYKATFVAPGITDDSLPVCVDRRGRLCYNIEESDPADRYYVAHRNRKIDTFGEASDDVSGTNTTSDAPSGLDYIGCGKIESMVLLKICADRAKVESVFDIPASRLRDWLCTIWFELPATRPCLPLMRLCIHWIDSREDSTFLKDAAFALVQKELSLLGEFQGGRLVMLELLSFMVERNGDASAELSKIVDIVAEGEENTLYAIMDSIVSYNLLESDMLDLWCLLCILPWPVASPTSAICRLLSSTFLIFYQIAYDAIKSGSGQDRFSSPPMALLENALRICTCRCSSPVLAKGALMQTIMLVELSPLPALKMKNAPLILSSLSPFLWKCYFVWSNCGRDVDPDNLTALRHLYDSLRRCVFCEPLSSADRNITTRTLPMFPRIRFTTNEGDEDDVNISNFIGTTTQVISTVSAPEPEEEFDYSYAPQEDSAVDDVPNVLPLEQPRGIRNLGNTCYYNSLLQALFHTRSFVKGLFDLSSSNTTVAVYQRLFRKLLKRGKKPFDPNPGYKLLPAAWRQNSEQQDVTEVLSHLLESLDESLELWRRLFAGMVVRRIKCLHCGNMSDNREIVMDFTFTVDNMSSIQAMFDDFCKIENLRGGNRYLCAKCDAHRRADMWNVIASPPAHLMVVLSRHMWSPVAALQGSSGGASKLLNHVHVDEQLRICEFDYTLYGTIFHSGTGASSGHYYFVGRDSEAPSNWHVCDDSQVRPATAATVNEISKDRGNSHVPYVVFYRCSQAPLTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6S9</accession>
    <name>A0A061D6S9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">dAMP1 SANT/Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0109420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766830.1">
        <property type="nucleotide sequence ID" value="XM_012911376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6S9"/>
    <dbReference type="STRING" id="5866.A0A061D6S9"/>
    <dbReference type="GeneID" id="24563185"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109420"/>
    <dbReference type="OMA" id="HMPGQMQ"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="8">
        <location>
            <begin position="90"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="671"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="765"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1039" mass="119719" checksum="78567B2C2E920A03" modified="2014-09-03" version="1">MFLQTSGSNASQTGDKPNTNVWRLCPFRNPARSDGLVLKHWRQVIRNREAPKVAPNSPLELQEKYAQTLDSDVTSTLPKLDEESAPVDSYPFAKVAPAIKIYRYSDEFYRYQIGDLDPSWTKEETDLLFDLCEMFELRFVAIHDRFKWRKDVTLEKLKHRYYTVTKRIIEYSFEEKIKTEIAKHNNPSHPVIAALRDESARHPLVKFTYNMEHDRDRREMLERSYRVTEEQRQAEAQLLDDIKQAESLFKREERKKVEFKKLKKKFSVSDDAITLPNMEKLHSKDVWLASDMVTQYKAQLNPKHNDAVDEMLAALNIPAPVVSSRASNELYCVVRGDAAIMINLVNKVDSLRKELEHWKAIAGPLPEQTATPKAKEQRTGAHTTPIDIATAFQTPRNMEPAKPFPKPKYPTPQHVGTHQMSQSDDGASMMSDSSKHCGEQSQMEQEHQNQNVMYHQQLARQRMLMAQQQQMQQQMQQQMHQQMQQAQMQQAQQQQAQMQQAQMQQAQQQQAQMQQAQMQQAQMQQAQQQQAQQQQAQQMQQAQQQQAQQMQAQMQQAQQQQAQQMQAQQQAQQQQAQQMQQAQQQQQAQQMQAQMQQAQQQQAQQMQAQQQAQQQQAQQMQQAQQQQQAQQMQQAQQQAQQQVQAQAQQLQTQQTQAQQQLQPQQQPPQPQQAQQQLPGQPLQTSPRQQSQQQAQQQLQAQQQQQVQHAQQQVQAQAQQQLQSQQQVQTQAQQQLQSQQQQTQAQQQLQPQQQQLQAQQQAQMQQAQQQGQQAPQHGSAPQSQGQPQQPLQQQSRSQMPQMYPMKVGAPGASSPHSFQQQGHYQQMMPHQPPAHMNQPQHMGQHSPMAKQQSVHQMQQPSMPPPHAMMAQHRAMQQRMMPYPQYPQQQFQQGYQQQFAPMPMRINPQGMYYPNQMYPQGGPPHYGHMMQHPMAHPQGQMPAHMQGQMQNQAQGQMQNQMQQVVGQMQGQMGGHMPGQMQSPMHGAMNAHMPGQMQGQMGGHMPGQMQSPMQGAMSGHMPAQMQNQMQQVVGQSQQMPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D705</accession>
    <name>A0A061D705_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="7">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0110070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="7"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766895.1">
        <property type="nucleotide sequence ID" value="XM_012911441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D705"/>
    <dbReference type="STRING" id="5866.A0A061D705"/>
    <dbReference type="GeneID" id="24563250"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110070"/>
    <dbReference type="OMA" id="NYGYRAT"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="657" mass="74572" checksum="29BC6AE55330FB5E" modified="2014-09-03" version="1">MADDTYLVCSVPPENVRFLASPDEFYRTLCKGYESAQKRVVLACLYVGCGELEEQLIRSIVTAKQRNDDLTVDVLVDKTRTSRVGSSGKIVSPLTQLQPYLAPGHQTKVSLLHNPLLGRLCSKVIKSPYCEAFGTMHIKVFIADDQCIITGANAGRDYFCDRYDRYMVVRDPLFADLMHTIVRTFQTASFELTENLTVEWHSDFVNPLEDNLLYRKQLYIRTAHMVNKCREILEKNRFHGHVDANGDVQPHPADCYTSNRSYRDCSPLSANSSYPEGCCDDEVDLGISDQESQDDPNSPHATWRKRTSSERSSLEGRPDLAAQQRRVTGLRGEDDQAQKSQNTDSSPDQAVRTKIPKTGGAVDAKTNTGSDYISVGRTNKESPHSRGERGRCGLSYILPDGATTDGSAEELETEQNGEKEGEYYCHIKICVQLPFTDPPFMQGATMLENWLLQYTRAGYSALIATAYMNFTERYMEMFKEILEIGKTRGKRHPLQVVTSSPYANSFYRDGSLKRNIALFYSTAATWLFKALRDEEGYPEDIYMEYNRPNHTFHAKGIWVLKDRIPVDVAHRSEEEFDAAVEPPCATVIGSSNYGRRSYGKDLEITFLVETNSPQIRRFMRRELYQMIKYSEYVNMDVVASRIGPHQHLIGHIMKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J5</accession>
    <name>A0A061D7J5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CCR4-NOT TRANSCRIPTION COMPLEX RELATED domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0211040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768143.1">
        <property type="nucleotide sequence ID" value="XM_012912689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7J5"/>
    <dbReference type="STRING" id="5866.A0A061D7J5"/>
    <dbReference type="GeneID" id="24564498"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211040"/>
    <dbReference type="OMA" id="CRRDYEE"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="132"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="673" mass="75401" checksum="CDF7EE93B4A11B31" modified="2014-09-03" version="1">MNTHHKLMDGYKAESYGNDAEDEMLCPLCMEVLDETDRNFYPCTCDYQVCLWCLHYIRTTMGNKCPACRRDYEEANMKYKTSPRVPTTSRSSNPKKKREAGEKDATTREERSGVPSQLSNANLKEMRVIQRNLVYVVGIPARIAKMEILKQHEYFGQYGRIQHMVINKSQSYNSHMSGASYTAYITYSRKSEAALAIQSIDGSQVSGRTLRASYGTTKYCSFFLKGLKCTNIDCFYLHQYGDESERISKNELTSLMHKTSKSGLSRTSHGLDTHAVPKGREEHSGRHPNPRRVHRIHETLQSGKRPEGGVDTYNAYPAGATHSDRDTASWAHVAAGMRDTAASVQPSVPYIYPHPEEMQFQYSVVGEAYPDGYAHSYDQYRPQRAKSDYQAGKRVKAPYQPHESAQNAAAATPTGQSEVLRHLFTESLISHLQRYNRGEHILYAVDMPANRGHPAGSHSGQQADGAPAAHDAANAAQGRIWMMAEDAKASGAYYVSNRRRQLDYYKGANDLFLALEGENAIAGTTAALDPKDIFSDSAAVEEILEKVKQHTLMLRQMSRMYAVKPQPAKAAPQQRSAEEKQPKEATEAPKTSYSHPVSTSSELQHAHEASAVAPTKAEKYVTSILFTSPQQQSQLEADIKLHEELVEGVQKLLHAQLKREQRYAKHMADLYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K3</accession>
    <name>A0A061D7K3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0211140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768153.1">
        <property type="nucleotide sequence ID" value="XM_012912699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7K3"/>
    <dbReference type="STRING" id="5866.A0A061D7K3"/>
    <dbReference type="GeneID" id="24564508"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211140"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="209"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="632" mass="70245" checksum="1B8E4FB68733AEEE" modified="2014-09-03" version="1">MATHFSSSASILLIQSIYGSWNSNWLLAPVEAALNASRTVTLNDLPNATMPLKESAIDGPIQGALKDNEVMFPMYKLEQCSTYDYIGMDFPRGRPQCNSQDHDHDDDFDLVDGIIASSSTLHGSPYASNIRFRQCKVEATDQGDTVVITDGVIYDVTKMMFYINAQLSSAAVAAIFAYLAITLCGLYRFIELLRDYAHGCTCRICRREFRLVRPIEGGANGKIHLARFVGAKCNFDLEVILKSIPVGDVSSISVTQEECRKLLSLNHRYVMKYYDDFIHREWGWNPLGRATLYCVIVTEFCERGSLADLIEQEYDTFTEEYIVTLFKKIAKALKYIHEQSVIHRDIKSPNIMLKANNVVRLGDFGLSDTFATKRSRRQARRVNILEIAAKTKINANRRAKAPMESHADSSPSSVSLSTPSQNTDSDCKGPSTPKNDKFVTYSNVEDASSTNTSVGRGMHSDGETTYELSDWVSPFSSGELDDCADTAAEDHDVPNPVINATSCRREKTQSTLAFYEEGSSNQKPIGTHCYMAPESIKKCVYGRAGDIWALGCVLLEMCSGVFMWELTYNLGECPENVPILVSQLPPMISRSTRVLISRMLSVDPKLRPSAAQVLKSPAVKGITSNRATQDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7P4</accession>
    <name>A0A061D7P4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767105.1">
        <property type="nucleotide sequence ID" value="XM_012911651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7P4"/>
    <dbReference type="GeneID" id="24563460"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200760"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="107" mass="11929" checksum="91E99AF759412795" modified="2014-09-03" version="1">MADDKAALAEDTNPCKCIFNIRCISKNCDECDKGFSCPCRCCQNNFTRGLLILLALGGGLACILLLLMAICHMIGSRTWPFHKIHDLIYGLPDIYDPYVRDPPKGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S0</accession>
    <name>A0A061D7S0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BRCT domain containg protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767135.1">
        <property type="nucleotide sequence ID" value="XM_012911681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7S0"/>
    <dbReference type="GeneID" id="24563490"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201060"/>
    <dbReference type="OMA" id="KLVTPIW"/>
    <dbReference type="OrthoDB" id="363344at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="439" mass="50004" checksum="65332CAFF3273317" modified="2014-09-03" version="1">MANDVESVFRLVYEDLGIYRNEGNGLWQNRTFCIVGFEHEIPSGAELIKYLLEALIKRGASVVKLPNDKLENKTLSIVDHYLCNYSLGYNALAHDILETKLVTPIWLYTCHRDARIHDTKMLPIFTPVGVFCPLMFAKDDVTIWIVSEMPSKELRHSSDVLSRFARHCGFKIMGFGDTRSVMGQTLDTAADSHIIAYANKHKLPCVAIQWLIDCYVAGEIEDIKKYSVDIQFEATMKANSKKRRISAIDATIAACIQEGRVMCLSYSAAVEATEEVREMIRSKEIKVHVINPLYLLAPWSMEQISGRERTLYNNLSLVDEDRIILYISRQEARNGAFGIFAQISMFMDYCKFRRKKRNKAVRNIEIHPLQDMYLPAYPGVESAISIPEEMLAGDSLVSRGRTRSFNLYDLADSVAFMGDDNALLEEEEMCGPDIHVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7X1</accession>
    <name>A0A061D7X1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768283.1">
        <property type="nucleotide sequence ID" value="XM_012912829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7X1"/>
    <dbReference type="GeneID" id="24564638"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300020"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="118368" checksum="C7646236BE022959" modified="2014-09-03" version="1">MNIQAKLADLHRRICNIPTNGDADTKEIARIIKYLEEIPEQVEERRRTALTKMMALESNIDLLHKLLDNVDVNVTLAETDIQSSIDSINNALKQAVAKCQATISSAFSTLTAAVRTLFAEQKKADLHALKGVVEEQMKVIEGIIDKDKRTGIKGLLKAVNGMKVTIISSDSPTFPTSTTELLDNIKKDLPLSTPFTKGHFTQLSTKFHDYYKNVDTYIKDQVKPPTSPPPTNPASKLTKIKDDFDKLLTHLSASNSTKKYNYDNTFVSLLNALSSSLHSLSPSAFANPRHPELLDAVRAGLQGFVEEMERVYVNGYDGHEEGIKFDELVIKGSDKDEKLSDDGRNLSKVFLTILETLYHDFVGLQNGCKKDASGNTQQLCQYVEANGKRNSNRLGSWLKERGYNVPSTKDKQDGELNSKKTGKDIYDELLIKKLENASSNTILTTWKTTKNSGTAGSTSNDDITLLDILGFFHDQLLDYFKTSHLRHISAPKAPCNVYQMLQWLTGLRHNPMYEKLCAHFKGLFKKPEGDKAQTESAYKLESTDAKLNAEELSTMLRGVCNISVDVLVAIQGHGHADGVYAVDFYVNSEGLSYPSNPGQCFDLLVDVASRVYHQMLFVYKQCNNGPQSSGWSDCHYGRGIAGSAWNCNTLQCPDQECKQKHDQTADQHYKCGVKSPLQSFLEDGLPGFLPHQFTKPGCKLECAVPNHFGKPCLTPMGFADIGIAASHTKQGKHLKEVLEKFCGNADQRLTKLCSMLTCLLQKPPQTLGDIFAFYHKFLNGWDGSGKHRKDAFDESVDKANFKRHYDKLNAYSVFDSTHSSNSKSHSNGDLVSLVCHSTPSGRCGPYLYSLYNEISGSFSKKHADKYVSWIVYLTPTFYDLLKKLYDDCCKSCGGDRPKCRVAKCPPTCATTKNTQNTNHSELCKSILQCDTTASVLCRYGFALSDRTKLSGTEKAECKRTCKDLCEMLKKVLDEESVLMKLFHSIDKFIYTIRFPFMTLTLALWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKFNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J9</accession>
    <name>A0A061D8J9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769222.1">
        <property type="nucleotide sequence ID" value="XM_012913768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J9"/>
    <dbReference type="GeneID" id="24565577"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309390"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="131" mass="12927" checksum="829449DB993AF23B" modified="2014-09-03" version="1">MRGLGAAVVAVAVGECLHRLRGLGVVVLQLAEGTGSGSGTCCSWLRGLGVAVVEGTGSGSGTCCSWLRGVGASVVDRTGSGSGTCCSWLRGVGASVVEGSGSVSGTCCSWLRGVGASVAEGTGRERGRWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U4</accession>
    <name>A0A061D8U4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acuolar ATP synthase subunit family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0302910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768573.1">
        <property type="nucleotide sequence ID" value="XM_012913119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8U4"/>
    <dbReference type="STRING" id="5866.A0A061D8U4"/>
    <dbReference type="GeneID" id="24564928"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302910"/>
    <dbReference type="OMA" id="HEFRQTE"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="126" mass="14212" checksum="F95DD0F24F2F88E7" modified="2014-09-03" version="1">MSSTKGSNALIQQLLKAEEEAEAIVKRAKENRVKLLNEAVSAAENDLKQFSETEERRLLEQYQKEAASDDPNLDDLENKAKELIRENDEALRECKSKLVNELAAAVVDIDVSVPDSFRYFVSRNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8X7</accession>
    <name>A0A061D8X7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769189.1">
        <property type="nucleotide sequence ID" value="XM_012913735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8X7"/>
    <dbReference type="STRING" id="5866.A0A061D8X7"/>
    <dbReference type="GeneID" id="24565544"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309060"/>
    <dbReference type="OMA" id="FVYEPVY"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="472" mass="53403" checksum="3962DC6792720B9B" modified="2014-09-03" version="1">MDVAAAANRFRRRMRRALYRLMARSEFFIDRNTGEDHWMYKKVKMMANRLVSAMYKTESAIVMVTGPPGSGKSYLVTSALMLLYDTIAMDVEDQGVMEFDTEFEPMEGLDGLSSDAESVSEMPWRVEIIMLEIYNYRDEMKCMKHLALLLEKLAGVSGSRCGIARCQEVQERIMHCMKLLRKSHVYVVIALEGMDVLTKGRNDCSERTGSCHRRQGMLYFIGNMLACEDIAFALVGVTPDVRTMERLEKRVRSRFMHETIHCDRTADYDAVAAPGKLSLLGKEAVLFLDDESKQMLGEGLLCGRSATSTIAATCAQLYDDAFEVMEDGELCISSDAVTAKLRDSGTTRWFESIVEHLSLPQHYVLVSLARLHLQGIMPLTLLGVERDLKEMCIYYPNEKKAMPHFNPDGMLEPPRPHQRPASGERPLQIPLLQDVSQKPNGLMRPRYAKMDHSKLLPTHLAGWLAMAVRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D911</accession>
    <name>A0A061D911_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0303660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768648.1">
        <property type="nucleotide sequence ID" value="XM_012913194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D911"/>
    <dbReference type="GeneID" id="24565003"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303660"/>
    <dbReference type="OMA" id="CRKEANR"/>
    <dbReference type="OrthoDB" id="364509at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="138" mass="16483" checksum="0FD929CAEAD211A9" modified="2014-09-03" version="1">MAEQRPPLYLRIANRLRQANGDTPMSYLEFREADYKLSKERHEVIKIIGARIRDMCRAELDDYVNCYAEKTYATFSCRKEANRMKRCVRHYQEFLATPESQQRIMEERLRSGESLIVPSFLKYPEQYQPPYLHPENKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D986</accession>
    <name>A0A061D986_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase II, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0206320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767660.1">
        <property type="nucleotide sequence ID" value="XM_012912206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D986"/>
    <dbReference type="STRING" id="5866.A0A061D986"/>
    <dbReference type="GeneID" id="24564015"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206320"/>
    <dbReference type="OMA" id="DETKFHF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="402" mass="44140" checksum="12EFB45CFA63A189" modified="2014-09-03" version="1">MEWTTRNLRPSIDIVSLTSSKMVFILLNADVATANAMRRIMLSEIPTLAIEVVTILENTSVLHDEYLAHRLGLLPIDSRNARSFEYRDKCNCSDKCSRCTVEYSLDVKCQGESRVVTHYDIKLDSWDNARGAAAAPMPVPRPSVDTLAGTYGNTSYAAMDGSMENNANASAHWMEAPTESAQSAVGGAASSGAAYHGSAYDQPRTKDFEDAAAPTGGIPIVKLKRGQAISMKMTATKGMGKFHAKWMVANVAYKMEPIITINKHEAEKLTLEDKTLIVNSCPRKVFKLSSPKSMFSSTTKSELVVENLLDCIYCDECLNQAREMGVRDLIRIQPDETKFHFTVESNGAIQPEKILEICLITLEEKLAGLQQHFLEAQARSLGTKSQSTGRPGAPQPRGIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A2</accession>
    <name>A0A061D9A2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0206520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767680.1">
        <property type="nucleotide sequence ID" value="XM_012912226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A2"/>
    <dbReference type="STRING" id="5866.A0A061D9A2"/>
    <dbReference type="GeneID" id="24564035"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206520"/>
    <dbReference type="OMA" id="FHNDMKS"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="74"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="662" mass="75679" checksum="23C9E3F5FEA6FDEB" modified="2014-09-03" version="1">MLFTRTCSPFRIVTRGTALKVLNPLRSHSVGKMADNNDASSPLREWIMPDKNGKHLTGLLVRNSLAADAKVEFVPEKGRRINWYCCGPTVYDTAHLGHARTYVACDTIRSILERYFNYDVHLVINVTDIDDKIIQRANAEQCEFKELASKWEHEFWEDMAKIGVEPPNVITRVSEFLPEIIDYIETIIKNGYAYESDGSVYFDIEAFRTNEAHVYAKLEPTSFNDLGRIADGEGALGETSMHKKSSHDFALWKKAKPDEPFWPSPWGNGRPGWHIECSAMCSTVFGKDSIIDIHSGGIDLKFPHHDNEIAQSEAFSDRNRWVNYFVHFGHLHIQGLKMSKSLKNFISIKELLNRYNRRQLRILFLTSRYDGTLNYNPGPQGMAEAVAIDETLFNFFSLLNSRLDKRANVQKLGENDRKLAAEFDTLKETIHAAFLNNFDTPKVLKAICGFIGSLNSYLSTPNASLKHAQGISFKNYLYKILEVLKIVEPGQEYGVEKSSEGTTSGPLLDHLVSLRAKTRLFAQECMKTKQVDVSKTIELLKSCDKVRDEQLPELGILLEDRDDGDCVVKFKSKDEQLKDNQRKEELKQQRIQQEKQQEELLKTHPSEFIARKFPGKFSKFDDQFLPTHLADGNPVSKSERQSLSKVLDKHTKQYLKRQENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9F9</accession>
    <name>A0A061D9F9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0311990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769482.1">
        <property type="nucleotide sequence ID" value="XM_012914028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9F9"/>
    <dbReference type="STRING" id="5866.A0A061D9F9"/>
    <dbReference type="GeneID" id="24565837"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311990"/>
    <dbReference type="OMA" id="LWRCVTS"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="259" mass="29867" checksum="1B10FB0649549733" modified="2014-09-03" version="1">MDANGPEVWYASLPRITRMIITLSFALTLITTFNIVSPHSLLLDWQIIRFKYEVHRILLGCLYAGPFSLRWVFHTYMFSQFSSMLERNPVFASSVGAYLYFVVIQILLVSLFSLLIYWPTGYPMLCEALLFAIVYYWSKRDMWNSVSIYIFTVKAYQLPFAMLFFNFIMGAPMVVNIIGLISGHTYYLMREVLPSKGFPNLLSVCPRCFDYMAKKMENLLDFRRVDTYSGPGSYAYTPAARQQQPHVGFIGRGVRLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I6</accession>
    <name>A0A061D9I6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767775.1">
        <property type="nucleotide sequence ID" value="XM_012912321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9I6"/>
    <dbReference type="STRING" id="5866.A0A061D9I6"/>
    <dbReference type="GeneID" id="24564130"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207440"/>
    <dbReference type="OMA" id="TEEPMIT"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595594" description="Zonadhesin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1248" mass="139575" checksum="67DD690B2C1DBDB3" modified="2014-09-03" version="1">MRWCISVVLLLFSTINVYAQTSSPLVPPPIPLTPTEKEKLNRLRRSGDGYSKKRVEVNVTSNDVTNVVDADKVHVPGVTTEEASNFEGPRDIVQPTSTTVNDDISIPEIVDPYSPSAGNEWDFLGSSLVDGSKSTKPAGSKVLFDHDTSVWSQKDDEAAGSKTDNEEVFRYRDVRDVDNRILLKSLINDIEGNYQWEPKSAASLQAQKKWDFVFNSLLHDDENVAPPKSSEIDIARLIDNAESRNPPPFVKKSQPKFKRFIFKPYVPKLELGDGAPKTAKQRWKLLASNLRDVIDKGNKPVEVSTDISEADMNKDDNNTPAPSSEEKVAIVAPGVSETEVPTSTTDEIENNVPETVDEIPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEVIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEIIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEIIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEVIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEIIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEIIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEIIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEVIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEIIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEVIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEVIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEVIEETPAAEEEIEIEEEEVPEIEETEEPMITPIEEVEEVVPEIIEETPAAEEEIEIEEEEVPEIDETEEPSCTVEEVEEVVPEVIEETPAAEEDVKIPEVDLPTRFTSEEERKRASDRRKAFRGAGTKHLDYQFIPVVKYGATDNASTSSKDRVKIRVLNVPHRGSRRPLRGKPADDVNMLADESSTTPISPVVEEPICAYRIKRRDDEESSIADESVSDLYGKKASKVKDKDSSVADAIVEGNSENVDFDLEKLLADERRDSFDLADGLASDNGSGSSDVNGGAAGANNDSRASAVDSGIFGGANLPGSAVDCGAVNGVSSEGSKTDKNYNFDLDEALPSDVDFTGDSDAEEEKKETEVESKDTVKPEPKKTGGVRQFFTNLFCCGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9M2</accession>
    <name>A0A061D9M2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0107340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766611.1">
        <property type="nucleotide sequence ID" value="XM_012911157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9M2"/>
    <dbReference type="STRING" id="5866.A0A061D9M2"/>
    <dbReference type="GeneID" id="24562966"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107340"/>
    <dbReference type="OMA" id="VFNELEY"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="762" mass="86131" checksum="54909A3A04D88067" modified="2014-09-03" version="1">MRRRGGFSDDEAYGSDYGHQAIDQCKLLEEALFYVKEHAYFMRQALDANDIGEALKRGINVISELRTSSLTPTNYYELYMKVFNELQALSEFMGNESKRGMKLNQLYETVQQSAFIIPRLYLLIMAASHCIKGGVASAKSILDDVTELCRGVQHPVRGLFLRYFLIQLCKDKLPDSDPTNSKGTLESFEFLMGNFKESVRLWVRLNRGCTSCVDQNWWDKQRLELGLLVGANLVRMAQMESLNCEFYTETALPSILEEIAAVSDVSAKKYLLDCLIQAFSDEYHLKSLPKLLKVIVSSISSNECINVLTNLMNRLSQYFKSADLSGDAVSTGDVFEVFHKYLSSVDLQNGISLKGFLDLQASFVEFTTTVYPGIIEHVEVILNHVVNVLQICDTENMRVEGDACASIITLITLPLRSLGLRSLEMKHNDPLVGFLPAHMQRDVARAMVEAMIESNLTIDSCDAFEITSRFLLPFFASPNSHEEAHKLRDDQQYVSKLIQIVQSYDATQQFGMYQALLERMVRSGPMFYRHSLPTLVLRSLELAFRPFELSGESTPTNRAMDVEESAALAMRIFKFVSDMIRMLQPLIPEKALKLAILAAISVNELCELLRLDMHDSANYERFGMACYNFIATACVIYEEEVILSQRQHQCLLYLVSAFSSKITVLNAEHYGSMSMRLAKYSLGLLKLEHQCAALAHVAAAFARCDDSSKVTWALQRSLAVVMQHQFTPEDQIRAALSPVRRVALQLQSQFDVVDLVEAIDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9P4</accession>
    <name>A0A061D9P4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0313090</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769592.1">
        <property type="nucleotide sequence ID" value="XM_012914138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9P4"/>
    <dbReference type="STRING" id="5866.A0A061D9P4"/>
    <dbReference type="GeneID" id="24565947"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313090"/>
    <dbReference type="OMA" id="NAGRNKN"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="345"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR97406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="530" mass="59309" checksum="8FBE51EF12DA56AC" modified="2014-09-03" version="1">MKLDPSHFSHLGNTEFRVLTAIELGMRNHEYIPLKLITATANLRSCGMSNVLASLAKAKLIVHCNESYDGYKLTFLGLDYLALRALLKRGVISAVGRRIGVGKEADVHLCTDAEGNLLVLKLHRLGRVSFRAVKHKRDYMGKRRHASWMYMSQLAAKKEYSYLSALWEENFPVPQPLDINRHVIAMKFVDGVPLSQVREMAEPKRVLHMLMKLIVRLARVGIIHGDFNGFNLMISEDGKQVTVIDFPQVVSVTHEDAEFYFDRDVECVREMFRKKFKMDVFEYPRFADVVPKTDDPNSCGRLKLKVVIDKVDDGILSEILQHLRQEEIVKQAESDPQQISAQMEKLSLKPGDAEKDGDEDDESESDSDYRSSDDDDPAGSPRLSESPGSSEADNAEKCGYDTDDEAEDDNDQDAESSANSSVTEDSTPEDSSDVESDPADGGVEEDEDSSDSGYDTDDERDPGEADGTRAEKSKPIQIWTPHVKRINASAYGHRINTRARNKAKAETKKGHKQRKQLTEANLAVKGGGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U5</accession>
    <name>A0A061D9U5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766696.1">
        <property type="nucleotide sequence ID" value="XM_012911242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9U5"/>
    <dbReference type="STRING" id="5866.A0A061D9U5"/>
    <dbReference type="GeneID" id="24563051"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108080"/>
    <dbReference type="OMA" id="IHQRIET"/>
    <dbReference type="OrthoDB" id="367230at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="2">
        <location>
            <begin position="240"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="611" mass="69392" checksum="54D92D5508F02E77" modified="2014-09-03" version="1">MRGIPARARFRRALQAEHRPGARIAEPDWQERNDRVFRDRLVHMPEQFAEASQRYSSDPRDYLLSSLLRHCVTRRSRTRGWDVERSQFMSSVADGTAELMDKLLACECGIVLRCFQKMEYRDYALQRALIERMLQRGQAFSPYAAVSALSTLAEGYAGSGASQWRTRMEETERLLRRLLAQVRAHMDRFNLGSLARLTNTISRLPCDVGGVLSSVRDSLFNRHIPESDAALWTEEVVHFFANGLSRKGMLDKKLFDFLRERIMESCPGYSVDTLVSLSNAYSKFGSAEAAGYIELFTRLAEEIVTQRHQLTNRHVCVVANAFAMSCLCHEDLLEVIDDSFVFGIDAYDGRQIAMMIHAFNKLGYRSRNNRFIWRKCTEHLDTYSWQGLTMIFHAYTKGEIRDQATTAKFCQRFVQLFDDLERQRSGVAAHGPTGADLPQPTTYVSLVYSLVKGNILQSDELLVHLAKGCLSNLSTYEPDEIANLALAFSRIRNYAMRDGEGTRQELSRLCQEMLEGLTMRLGETRLQFSAFSMAKVVEALGDCAFMQSAQAVLGLVKRNILILDRLSYTHITAIVIHDDDLMSVLNSLKHNKRIRHAQASAPPAAAQHRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X2</accession>
    <name>A0A061D9X2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767900.1">
        <property type="nucleotide sequence ID" value="XM_012912446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X2"/>
    <dbReference type="GeneID" id="24564255"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208680"/>
    <dbReference type="OMA" id="NPVFRNY"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056326">
        <property type="entry name" value="ISD11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23511">
        <property type="entry name" value="Microp_apicomplexa_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="85" mass="9641" checksum="EC0FB4827CFA54FE" modified="2014-09-03" version="1">MSLQKLVGVLSRVKTAAESFRNPVFRNYFVGKAEEELSLLRERGASMPSSELESRLHSNTELEAILLRQTTVHNLYYVSDALVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Y3</accession>
    <name>A0A061D9Y3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766741.1">
        <property type="nucleotide sequence ID" value="XM_012911287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Y3"/>
    <dbReference type="GeneID" id="24563096"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108530"/>
    <dbReference type="OrthoDB" id="5334309at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="173" mass="19927" checksum="D83A2C44D871D19A" modified="2014-09-03" version="1">MSAVSHIVRLSADVWSLNGLGGGIGGVTLRHLLRRRYDEAAAAVKRVVYPDGLHQGSVDTSQVAVTPQILPNGGYNVPILDELYRRTSSGLASVLEGLHILLWKGKQFKGCFQPSKWKWYHRHGYWATRKKLLKFDTYRRHRYHEVRGPGKRPPSKWEDKSFYKPLRDSIKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA11</accession>
    <name>A0A061DA11_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766771.1">
        <property type="nucleotide sequence ID" value="XM_012911317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA11"/>
    <dbReference type="GeneID" id="24563126"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108830"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="7857" checksum="9FC5BA7E2E357A0B" modified="2014-09-03" version="1">MGNTCACSASSASSGAGQGQGECKMNCKMSILIGVLIGVVCSFLIFAICFNVGLLALETDVFSNMFRKSPSLPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA6</accession>
    <name>A0A061DAA6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vam6/Vps39-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0209570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767990.1">
        <property type="nucleotide sequence ID" value="XM_012912536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA6"/>
    <dbReference type="STRING" id="5866.A0A061DAA6"/>
    <dbReference type="GeneID" id="24564345"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209570"/>
    <dbReference type="OMA" id="CCELASC"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="15"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="958"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="990" mass="111705" checksum="29B1A9E8CA3AEA0A" modified="2014-09-03" version="1">MEIFSRGAVLRWMESSKITAVAWCYNNLIIGNDAGELYAFQAAAVESPVESQIYKFSKVSNRRIARICPLEPKEWILVLNADGDLYVLDAFFKGHATMLCKRVTAVGRRLAEVSYDAAAKNGPLNALVNLNQFCIGTDNRLYLYSAEDQVEQQRAITVDGVVHSVSWFKGVIVVGTKEAYYLLDAEGTVCHELCSNLQMDEKDVGAPALTTACVDGDVMVVCQNIGIFYSTETLNLSKKNTIQWRNRLEALGCAPPYVIGITVDRLVEVYGVRDQLLYQTIDQTNATIVHYMPDRSCVLTATPNVVTVMKPKSYHQCLTDCIERKDIRQAMHLADVYFAADDPMRPVETKVAHTVAGWVRFADVNFPLAFQHFTLGDVDIVHLISFWNHYAELKVPDSYVRNQQVPAILRKFIPKASGISQYVVKRFNELKDVLPENTTVAKLLEMANVSFAAFLLKHFNPKTFLNRSGEPLDDFNQALVATVEKTNLLLLAECDDPKCSIIINRPREETFLDPDACGRHLLQMNKSEVFAKLLIKQERYREAMDIMAKYIRDEVGEVATEDVTLEIKSVCCELASCLNMLIENSHNEYTDSNTNVKPEEEIRDILNTYLPVLLSSYPNAALDVLTKNHAMIPFSTDQIVSMIDAYAQKVGSRIAGGYCTSNIAMRIKYLEDLVITKKHGTVHENTLLAKHYINELILHGKTKSAKDGVTAIKKTLLELLESNNNFDMVELEPLLAKLNFVETKVLVHSMFNRHEDALRTLFDWEESGDRTKRCEAYCMCFGDVAAVYSAVEKETPFKRYFSNFDYWMRRANEWPLTGHHIYNINTSDTSIDRLLLRLLNIIVEHSQRDEGCITVVRDLLAKYIPLCTHSSVLNASSIVELIPDTWNFALFADVFTQLQLKALHEQRTMAMKRGLTRSLHSQTAKNLYKLTCVPPITIDASSTCSICQEPIKLGMSIAIPPPSQSDATQQQGGKQPMLMHEQCAKNVHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAE9</accession>
    <name>A0A061DAE9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768045.1">
        <property type="nucleotide sequence ID" value="XM_012912591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAE9"/>
    <dbReference type="GeneID" id="24564400"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210120"/>
    <dbReference type="OrthoDB" id="365163at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595953" evidence="1">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="240" mass="25887" checksum="A4B9C89945DE8215" modified="2014-09-03" version="1">MKFPLLLIAAALLRAAEAFSTKTRHRGAESSYALSDDAHINMEGLSTDSFIAQFGGDVAVLVGGLVQDDSAEAAMSSPLNFFYSRKSEGSGSLQPSNKDIQKTVAECILTHHEAAGPKSRKIYLPLKDAEEYGKRIEHAKARVTPEPAMVTSARSEHGAARAPMDLVCKSVIISDDAKKCNVCLYAEILVPNKHVRYGHIGKASVLECLNGYDTELGRSGSSKTYFIDAPARYHPVCIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAF1</accession>
    <name>A0A061DAF1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0400200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769714.1">
        <property type="nucleotide sequence ID" value="XM_012914260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAF1"/>
    <dbReference type="STRING" id="5866.A0A061DAF1"/>
    <dbReference type="GeneID" id="24566069"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400200"/>
    <dbReference type="OMA" id="KALVLMM"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="359" mass="39940" checksum="6F840D8D07F1B999" modified="2014-09-03" version="1">MVVCVHCSSLVPTLYHESSKESICLETCAYCGEIADKYVEWDLYITAIELFLLKVAVFRHLIYNQDAKPSGGKNGTSARKRISHLLLLFASAVVLDGYRVMVTCRFITKSQEWCSDKNLMLQQAALEKAKEFFQGAAYPTLMTAQEAQFSADHVTPFTDIGSTTNLFQNMVQSMLASSQMKIISARKEMGMCDGSKPSSIVDQFFILSLQEPSLMTMGYRTCKTFGEWSTLLLCLTKLAGYCASVVIFQKVMSRHGYVSPSNNGGISKSVKEKINATPSTLDVLLAVLLCIHIKALVLMMIIWYPRLPLVGAIEVYAYCSNALAIHATCNMTMKQSSMAVAMAILIKLLIHCIWLRSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAN9</accession>
    <name>A0A061DAN9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769937.1">
        <property type="nucleotide sequence ID" value="XM_012914483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAN9"/>
    <dbReference type="GeneID" id="24566292"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402390"/>
    <dbReference type="OMA" id="YEFFPIF"/>
    <dbReference type="OrthoDB" id="360976at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="161" mass="18771" checksum="F783DF41B6CEBBEB" modified="2014-09-03" version="1">MLHVARTVGGTVFTRRFVNRAVTFTLGFITSYAFTNPDLERVWEVHPAFSQRDYAFLSFYEVDPEHSSEFENNVKCLTRYLQTQEGYGSTKLVRLENMTHGGQLDRYQYLGIQTWFSPDLMKKATSQSFSQRMIAKLRLRSPFNSVMYKIVVNDRDFVPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV8</accession>
    <name>A0A061DAV8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0212010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768245.1">
        <property type="nucleotide sequence ID" value="XM_012912791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAV8"/>
    <dbReference type="GeneID" id="24564600"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212010"/>
    <dbReference type="OMA" id="KNYGGQF"/>
    <dbReference type="OrthoDB" id="359911at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="208" mass="22576" checksum="44FCF04CA9AFB0FF" modified="2014-09-03" version="1">MVNSYGGSFIGFQAIREGASGGNDKLKKVLVAPKVPEGPPEVLVIDLRSATNINLPETKPPVSTDFVITAFFDDETVEEAFKHMRQSCKPTKGVYCYDSYTCQFDQQIVLPCAGKKHVVLYVSYVTIITAPDGSRDLDLKGYGLTKPIPLDSCGTVPIHKEQLLASNGTDTVSMALTYSVKMAKSSDSDQIPPDTLGGLVLRPKIKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAY0</accession>
    <name>A0A061DAY0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Splicing factor U2af, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0212210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768265.1">
        <property type="nucleotide sequence ID" value="XM_012912811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAY0"/>
    <dbReference type="STRING" id="5866.A0A061DAY0"/>
    <dbReference type="GeneID" id="24564620"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212210"/>
    <dbReference type="OMA" id="FYDGFQW"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="184"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="411" mass="47707" checksum="2D61FF4922011AFD" modified="2014-09-03" version="1">MAGGDYDAEPPRRYASDGRRESDSRHEYSRDSHRHDSRRDHRSRYSRRSRSRSRDRRSPPRRSSHRDRSRYSRGRDDRPRRYDRHEPESKDAHQERHEEDADALALNPNLSPSHARSRAAERRRRKAQADCIRRAGGFQKLADQEGHETVRLFWDGFQWVAKTGQAALMMNTDSAYMNSTRKLRRLYFGNLPLASGLTENAFQNIVWNEMRTRNFCNDPNVSPVLYVWFAKDKGNYGFVEFATVEETERALTMDGMNCMGAQLRVSRPNDYSTSGAKQPIPGMQTQNIIPPDAFKGSCLKVAQIVLPESVQKEIEYLDVLDDVREAFEKHGKIKTCAIVTPRHKDIAPNLKPGDVIVEFVDRESLLACVQNMQHRKYEKREIQFVPMEDEDYKHVAEPLILDLEALEREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB33</accession>
    <name>A0A061DB33_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769378.1">
        <property type="nucleotide sequence ID" value="XM_012913924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB33"/>
    <dbReference type="STRING" id="5866.A0A061DB33"/>
    <dbReference type="GeneID" id="24565733"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310950"/>
    <dbReference type="OMA" id="VDCLYLV"/>
    <dbReference type="OrthoDB" id="360701at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39394" checksum="AB75828829AAD483" modified="2014-09-03" version="1">MTKLSEAQDQVERLKQQAEKFLTCDDDGLLSLYDEYVQFKALLTQLLSTVARYRIQLSSTDATKVFWGPKTRLVVETLVRHYDKVYEIDEEQLAPRFVEVERVNELLSKQAAEDVDDDDEREEFSIIQETKEDLKRIQQAKEQLKNKPGFLQADLSNIQNQDSVVANAFYCVQQVYKNDPAVSLEDILAKLYKDDSDNFLLVLGNVSHLISQIAKHPDELQLRLLRVNNEQLYEDIIRHPAAVALLKYTRFKIKHGEEVKDALTQLGFTDISDEYFLYLNEPDMFGDYGAWKEWIDFVGSTSRLLENFTAAYKSIMRTKREDEADAVAEAMSLSRAAIGEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB46</accession>
    <name>A0A061DB46_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770087.1">
        <property type="nucleotide sequence ID" value="XM_012914633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB46"/>
    <dbReference type="GeneID" id="24566442"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403890"/>
    <dbReference type="OMA" id="YPSITCE"/>
    <dbReference type="OrthoDB" id="364801at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="193" mass="21365" checksum="818A51022032D3A4" modified="2014-09-03" version="1">MLACCMCSGQSAYTLRRLRTQSCITFDFLVLNVALMPVLKRCAEGALVGAFRSAAAGKGRLPLRRALSELARLFYGDSDSTAKQSAEFMNEFYLRGVDVRCGLRSHALMVGGPKNIRGNPRGGLDARLFYPSITCEQFIMIGRAMECVLLERQVPHLAGGRLRAERTTNEVADVERKQRQKLLSEVTSTLSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB76</accession>
    <name>A0A061DB76_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768350.1">
        <property type="nucleotide sequence ID" value="XM_012912896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB76"/>
    <dbReference type="GeneID" id="24564705"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300690"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="62" mass="7128" checksum="7117E51DBCEE73BB" modified="2014-09-03" version="1">MATISQRQKTAIEVIQLPSLICSDEYGALSLHESIVDSIMQRFRHVKLLRSSNNFKHQEVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB7</accession>
    <name>A0A061DBB7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 8">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0403010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 8"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769999.1">
        <property type="nucleotide sequence ID" value="XM_012914545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB7"/>
    <dbReference type="SMR" id="A0A061DBB7"/>
    <dbReference type="STRING" id="5866.A0A061DBB7"/>
    <dbReference type="GeneID" id="24566354"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403010"/>
    <dbReference type="OMA" id="WRAVITI"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="360" mass="39008" checksum="4C9853EBD3C16648" modified="2014-09-03" version="1">MRFQVKLSQERAKELAENARRIAAPGKGILAADESTGTIKKRFDNVGVENTEQNRADYRSLLFSTKGLGEYISGCILFEETLFQQSPCGKSMVELLLAEGILPGIKVDKGLVPIPNTDEEVSTTGLDGLAERCQKYYNAGARFAKWRAVLSIDVAKNKPSNLSVLETAHTLARYASICQQNGLVPIVEPEILADGDHSIEVCAEVTERVLAAVFKALSDHKVLLEGALLKPNMVTQGVDCKDKPSPQTVGFLTSRALRRTVPPALPGIMFLSGGQSESMATVHLNEINKCNKHPWSLSFSYGRALQSSVIKTWNGSMANAAAAQAVLMKLAQQNSEASTGSLKGDLSDDGQSLFEAKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBE9</accession>
    <name>A0A061DBE9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0403460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770044.1">
        <property type="nucleotide sequence ID" value="XM_012914590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBE9"/>
    <dbReference type="STRING" id="5866.A0A061DBE9"/>
    <dbReference type="GeneID" id="24566399"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403460"/>
    <dbReference type="OMA" id="SPFFMNA"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="211" mass="22952" checksum="43886037DD5B2BA0" modified="2014-09-03" version="1">MAMESYKDNLMRLCLDRGALMYGDFTLNSGLKSDVFFNSGVLSDAESFSALVEVQVQLLIDQKLDFDVLIGLPYKRPESVAATAVPRNGISMAAAIAMKYWERTGKRVSFGYHRKEPKDHGEGSLFVGAPSAFAPGTRVVVIDDVLTTGKALFKGIDLVQPLGVNVVGVVVILNREPTHGTVAQALATRGIPVLCEAFTLNELRSYAQKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH0</accession>
    <name>A0A061DBH0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0301530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768435.1">
        <property type="nucleotide sequence ID" value="XM_012912981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBH0"/>
    <dbReference type="STRING" id="5866.A0A061DBH0"/>
    <dbReference type="GeneID" id="24564790"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301530"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="255" mass="29696" checksum="E2715584F4A6D083" modified="2014-09-03" version="1">MPQNEYIERHIALHGRRFDHETRTRKKAARAAHTMSKKVQKMRGIKAKIFRMRRYAEKVEMKKQIKNNEEKEAKEEVVASGEGAIPAYLLERGEVNRTKILSNMIKQKRKEKAGKWNVVRQMNEAEMFRVMKSGKRKKKQWKRMVDKVCFVPEDYTRKPPKYEKYIRPTGLRFKKAHVTHPELKTTFFLDIISVKKNPQSHLYTSLGVITKGTIIEVNVSELGLVTQTGKVVWAKYAQVTNNPENDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH6</accession>
    <name>A0A061DBH6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0301580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768440.1">
        <property type="nucleotide sequence ID" value="XM_012912986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBH6"/>
    <dbReference type="STRING" id="5866.A0A061DBH6"/>
    <dbReference type="GeneID" id="24564795"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301580"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="236" mass="25769" checksum="AB1B7C631017EB7E" modified="2014-09-03" version="1">MVADGEYNFSLTTFSPSGKLVQIDYALTGISKGAPTLGIKAKNGVVIASERATLSPLVEADSIYKIDHVTRNIGVVAAGMPADFRIVLKKGRKEAMKYKMMYGDDIPGAELVKEIASIMQEYTHSGGVRPFGISLLLASYDEAGPQLYQIDPSGAYFGWRATAIGGRMQNNMTFLEKRYSEDLELEDAIHIAILTLKEGFEGEMTANNIEIGIVGTDGIFKILPKDIISDYLNELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBL4</accession>
    <name>A0A061DBL4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rubredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770287.1">
        <property type="nucleotide sequence ID" value="XM_012914833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBL4"/>
    <dbReference type="GeneID" id="24566642"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405850"/>
    <dbReference type="OMA" id="CGFTIFP"/>
    <dbReference type="OrthoDB" id="194772at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00350">
        <property type="entry name" value="rubredoxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600776" description="Rubredoxin-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="2">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="150" mass="16539" checksum="C4A0F957B51FC03D" modified="2014-09-03" version="1">MRSFCLFILAIFISGVAAFRAGDRRTRVANAPLTPRRDEQLSLFKSDKGYILERISDSLNYISDTVNNRIPGGVATVITVPVVTAAAAIAIQNYLGPDKSKAAKPTLNRYQCSGCGFTIFPAKNREERFFSSNFTCPNCGAPKHKFVERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM6</accession>
    <name>A0A061DBM6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769528.1">
        <property type="nucleotide sequence ID" value="XM_012914074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM6"/>
    <dbReference type="GeneID" id="24565883"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312450"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="108" mass="11648" checksum="071F61124912C0F6" modified="2014-09-03" version="1">MHSCEDIGIALDGDCLVAGGAPVGDCQCWRVRLRGLGGEDGGEVGRFAQLQTSAEDRSTNPSNTSSSPAPYIIVPVALVIVVICVMIYFRIRPFHRSNDCVDDKSHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBN0</accession>
    <name>A0A061DBN0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767341.1">
        <property type="nucleotide sequence ID" value="XM_012911887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBN0"/>
    <dbReference type="GeneID" id="24563696"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203120"/>
    <dbReference type="OMA" id="NSDHANT"/>
    <dbReference type="OrthoDB" id="365948at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="399" mass="44571" checksum="D5D9480790773161" modified="2014-09-03" version="1">MSRVFVKQAPRLVRQHLPLVQTLSASAVVDALEDAANLRHRDSYVEEFILRCESRALALLPDLRLSGIVRSLFALKRANVRSGTFADEVARFLLEECATGKLYDGFLDCCTANDLLLLYKAFAVVGYFNVRLYTLCMGLLATQTPHMIPADCCVFFQSHVKYVEALKSGGFHNSDHANTPEMILCPSLATEITLRFLQQDDATPEDLTVFAEWLVRMGDYYGISDELSGRVAALHRALSPKAVMFSVDHIHRLVQSTCKIKAHMEPLHLPSSLLFIQSLLHEAERRSDIHTYENALATLHAVEDMATLPFELVSGLLYTVVNNVGPGDAERVRGILRKRIQGSGTDEVEFRSVPMEYKIDTCPPAVVAVKVCEPVCGIKILQLREMLERLDISHRISAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR8</accession>
    <name>A0A061DBR8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769593.1">
        <property type="nucleotide sequence ID" value="XM_012914139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR8"/>
    <dbReference type="GeneID" id="24565948"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313100"/>
    <dbReference type="OMA" id="EIDNTAC"/>
    <dbReference type="OrthoDB" id="366204at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="267" mass="28592" checksum="0B431709A9C6CE2A" modified="2014-09-03" version="1">MESDRSGLGPGNQRQGSRSKSAQQDAAASKRSTERPSRDRQMVPFFGNGEIDNTACVALKKGTAGQTRRSRRSRMPSAQDTPFSTPNGREVGISALPIGQSPLDTTQGHPINVDLAHLKNVGVSVSSNATIVDLSDKMSDYKTDDRDSEQLGSTCTMSSSVETLCCHDYDESCNELADPSGPYADAVGTLPHYGRAGRCCDASPTVQEKARQLVNMLYTSTKKDAHARKNVPSPGKSKPKAGKETGYVLPRYLCSPDPSSIPLPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY1</accession>
    <name>A0A061DBY1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pyridine nucleotide-disulphide oxidoreductase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0303030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768585.1">
        <property type="nucleotide sequence ID" value="XM_012913131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBY1"/>
    <dbReference type="STRING" id="5866.A0A061DBY1"/>
    <dbReference type="GeneID" id="24564940"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303030"/>
    <dbReference type="OMA" id="PRCTHYG"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="11">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="10">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="525" mass="57075" checksum="DF89F0BEC531E9EE" modified="2014-09-03" version="1">MREVPVHGGRDLVLVTNVKGKFYCTGAKCPHFAASFLDGACTEEHVICPWHNAKFDIATGECVNGPCFDAIPSFKVEVDGDSLYAYLPPTPIADCVDKPHKCQDAKDKRVFVICGGGAAAHSAAETLRQEGFGGRILIYGDEKYLPYYRPHLTKRIESKSYDKVASEQALRPLAWYRANQVEYYGGKRVTSVNHEDNTITLDDGSTVKYDKVLVATGSVAAKLPMTRGMAPLSNHFTIRTVDDLRELVPQIKKDTKVVIVGANFIGCEMASSLKSTGANITVITDMAVPMSNIIGERGGSAIMKLMQNGGVNVLTSQQVKSYTIKGGRVTNVVTANATLDADVVIEGVGARVEMGLLKCAEVNRDGTINVDSSFRCKGCPDNVFAAGDIVTYPYHIDGSPISVKHWNVALQHGRVAAKNMLGGDAKMNMVPFFWSNFFRKGFRFAGVANGVEDIIYEGDLEKYKFVAYYIKASKVVAMLSMGMDNVGANMAEALDKGCAPSYASLKLGAENSETMLQCLRKRMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY4</accession>
    <name>A0A061DBY4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation (RCC1), domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0405770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770279.1">
        <property type="nucleotide sequence ID" value="XM_012914825.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBY4"/>
    <dbReference type="GeneID" id="24566634"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405770"/>
    <dbReference type="OMA" id="TCFHAET"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="57"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="116"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="190"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="242"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="294"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="399"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="485"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="538"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="598"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="651"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="701"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="754"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="811"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR98093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1547" mass="169866" checksum="92F7F46784C3017F" modified="2014-09-03" version="1">MSSDVDGDHVTEKRPQAALVVALGLNHALCVTKSVALGEANAFSTGHDTVKDAEFNLYSWGKGNFNCIGHGLNTNLAKTPKAVPFFKQKNVLQVSCGDYHSAALVMPHGATSVSGGTVYTFGLGTAGRLGYDIDDHAQSSHNLPYSTTSDTESAWCTAEPQPVGLSVNLKHNVISLACGANHTLVTTVDGSLFSWGMGSFGVLGTGESHNSYTPVRVRFPYETFMTSCAAGCRHSFGVDDAGKLWAWGYGGNGRLGIGNTRTQYTPKMVGSLDEHQVKQAACGDTHSACIDSDGKVYTWGSSKGGKLGRRTSVDDAVIPTLVEALGDTKVVQVACGAGVTLALTEEGCIYQWGHMLGCMSTSADVPKIAHVPQKVTEAGSKNVYIAAGPYSCAAVNAYGDILTWGVGSCFRLGHGNVSDFQHPKFVAELRSRVFVDPILKQRSQTQDVHKSESPLELNAANVADERRIKQLSVGTAHGALLTCNGTVYTWGACKGSGFSDDTANAETYNEPRPLNYFSTKIRSIACGSNHTIAVTIEGLVFSWGQNDSGQLGLGDLRPRGFPEHVISLEYAIKAFAGFNNSCCVTTAKHDGFENDEVGMAWVFGSSSGGKLGLGDECTNAVIMTPRKITYISGVYKVVLGNTHSLLLQHDGTLYSTGSGADGRLGTGDTAGVNTFTCVKSGLKFIDMAVGASHSLAVSMEHDLYGWGKGAYVNGSDDTLVEPTLVANLPSQSGVAKVHSVAASSNHSFVITDQGHLIAWGDNSSGQLGVPVTSKDVASTGFIERPSLVTIESPVLSIATSRSFAACTTVNGDAYAWGTSSDGRLGIGETRDKVTYKPTAIATMSLVGDMLNRFDNMTTNNDLSAFALTVESLINELHFTEDKSVVDWKSLQIILQNEERLCWESSLKSFEDDLVKCLKHHVDFILELDRYHGEMNAQQSKLEAAIQGFIGNIGRPQSRPPSLFDRHFKVYTQLMPQIQQIVQIVFLQPAYLVRLCLFGNAITMVEDFVTCLYASMDKPRVHMQFVALLFTLLREELQLCFKPHAPLNASSSPFAQMLRIYAASKVISAPNARTFYSYEFNESFATFMKQHRLVLPCKAAPNSEELNNFTKFLLHLNKILTIITVPRYIKLAFKRMHNMVKFNIPSGWALPSVPLENVSIYPLIPVFVYSVLQPYFSSAVDMAASHGYNLDDEAVVSNFTTASQFFDYIANPSLRMEPHASQEVNRMTMAMYRNVSNMLLEYIKTLLSVEDTFNIDITMETFKSQFELEKISIELPGWTIAQFVNCCATKMKYLNISAHDTLCKILDGMMPKGNYTAINNVFGEEIIQKLRYHKIITPVEIEQRFLMHDKNMSICKFSGVFLPQRLAYRQTTCSEDCIKLMSLIIRYRPLGKYDPPRTIQNALTELKPIDMAPGGFDKLAVEMDTLAEHYINMGMPNHAAASRARYAYEQLMKLHDSGVTPCELAETILKKVLERQEQRNYLLRVYKRQREIEVCKINFEAAFRERCQYLARCIEHATKTYVEPAILNAACVNRVYLHSTKLVKSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC29</accession>
    <name>A0A061DC29_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0400590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769753.1">
        <property type="nucleotide sequence ID" value="XM_012914299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC29"/>
    <dbReference type="STRING" id="5866.A0A061DC29"/>
    <dbReference type="GeneID" id="24566108"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400590"/>
    <dbReference type="OMA" id="GEHFKYL"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="203" mass="23378" checksum="92E43FD59CC9A119" modified="2014-09-03" version="1">MANRTDPTAHLVHGTNPQFLFSKIMRDKVYNCMYWKESCFGLTAESIIDKAIELQYVGGTFGGNRQPSPFICLVLKLLQIQPDLDIIEEYIRNTEFKYLRALGIYYMRLVGSSVKVYETLEPIYSDYRKLRFRLNDGSYELKHMDEFVDDCLRLSSYLDVDLPPLPKRMVLEDANLLAPKVSLIDDSDEDDFVPELPVMGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC41</accession>
    <name>A0A061DC41_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769773.1">
        <property type="nucleotide sequence ID" value="XM_012914319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC41"/>
    <dbReference type="GeneID" id="24566128"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400790"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="291" mass="31854" checksum="6E0E15CCFAD5E076" modified="2014-09-03" version="1">MVYNSLTEAPQNLKEAIDWLMALKGDDAKINVAALGAALFSFLADKTVDKMETPALEEVKHVTKKFLDQPELRNQWFVGGLVKRYNDLINKSPGGLAKYFRVVDESDENVVKGKGITAGAIVENLGKVVHGTEIFLDDIKSPGEYESAYSSEATWSKSCTQKPEDCAAVFVGIAPMLYAGVRSLHYASIADTLNWAPSTEQELSLRKILKALGYVEPECRAGMGGFDVAKALRGLYLRTLITLCDFTGFWAFYGSNNPDLGAGKHGNYSLSGVDFDVNMKPIDASMKIGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC63</accession>
    <name>A0A061DC63_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MIZ zinc finger domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0205130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767541.1">
        <property type="nucleotide sequence ID" value="XM_012912087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC63"/>
    <dbReference type="STRING" id="5866.A0A061DC63"/>
    <dbReference type="GeneID" id="24563896"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205130"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="5">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="566" mass="63733" checksum="E12B511E805B42EB" modified="2014-09-03" version="1">MFTDTNLPLDFTYCLCYGEYVDPSDKSAPLICRSCEKLSHRHCTCYVGPDHDFECFLCQVQVLDPFNAVVEFLWYGRMGNKHEILKISAPQFDKWLAQNRDVYVVSLPLSKNKLVHEWPKTFELRINNELVHVVKAPNWGHTRRDNPIKVTYAMHTGDNMLELSSTTYDDPVSFFLIVIMVSKRISVERIIETIKKRRTITVFESKRRILEFLNTHFEDDDVICVKNNRVELNCPLTLDRIELPTRGKLCKHIQCFDLSAYLQVMQNMSTFNKRWKCPECPLTVKPMDLVIDGYMLEILKSTPQGASTVELNETGDYRVVNCSSMCKYVKGPAELGKTKNRDCATIQGDSSTFNNDHVSSDSGIGELHTHFGSKRSGTDDVFVKVEGGINVGYIINSDMSDLFSANTSTECTPKELLICLESSDGEEYSKNGAQRRVESQQPTCDKRDENLCDAFSQANSNALGKYASEVASGNKSSRGQLQAYGCPKSTLSQRLSNLPQIAGDAHITKSIKRITTDTYASQSFMPVSPSTGSAVTAKTCEHPALMKRSKQKTALDISALRFGFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC74</accession>
    <name>A0A061DC74_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0205330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767561.1">
        <property type="nucleotide sequence ID" value="XM_012912107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC74"/>
    <dbReference type="STRING" id="5866.A0A061DC74"/>
    <dbReference type="GeneID" id="24563916"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205330"/>
    <dbReference type="OMA" id="CAYRYTM"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="119" mass="14172" checksum="17F296D7CF8EA1A9" modified="2014-09-03" version="1">MLPRKFDIVHPKDLQFLESYDHLVVDNPHVGDPRNLQHTQWNYCRLRYALFCRCCKELGEGNPRCKYQYYRAEMACTQDFLDIANKYRDNGRRGFLSQQNPGTHSTDILPSRQVHNIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC3</accession>
    <name>A0A061DCC3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768815.1">
        <property type="nucleotide sequence ID" value="XM_012913361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC3"/>
    <dbReference type="GeneID" id="24565170"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305320"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="217" mass="24319" checksum="AB57FFCCDD8119DF" modified="2014-09-03" version="1">MHKAQDVNQYENNDEDEDGDDDDGNGEASGGNVIRGTLSTGVRGVSGGTAFLKTTKDGMFCYQCALGRVANIYCTCRYYYILYNTRGSNYKKLEDNNFYYNRSIVFRSSSRSPPSPLNLQPYQSPEQRTHQLQHVPLPLPVPSNCEHINHSSNALTYCNTYTAAPSPLNLQTCQSLKQRTHLLQHVHCRSQFPQPANISITQASTHQTLINTHLCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE8</accession>
    <name>A0A061DCE8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768855.1">
        <property type="nucleotide sequence ID" value="XM_012913401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE8"/>
    <dbReference type="GeneID" id="24565210"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305730"/>
    <dbReference type="OMA" id="HIWRLIE"/>
    <dbReference type="OrthoDB" id="390194at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="352" mass="39661" checksum="1EC303E8C4C16169" modified="2014-09-03" version="1">MSRTSLCKLHLIPSHAWLPLSRHVCLRTVGSRAASTTGRVFRTCLPGDAGTRPGWVPLSSLYGEHAEAADSAEPADTTSYDAEKGTKHGSPTINTPNQVLFVARKGLRCQVFDTKLWQDLYQRTVELSDHFQPRQWVELVHIFKRIKVRQGGLLNLATRQLLYHLERLSLEDLSKLALSFAYYQYRHTAMFDRIADVVTTRLRREKLQEGHVAATAPSDALGQDTDEPVKNRALSKITSYTHLVGAFARCDHAHKELFEAVAADLVTQVESKEMMIPPGFLVKIIASYARFGYRHSKLLDTLSKEMVTAKIPDEQLLQVQHMMKALEYENDAMLNLFAYRLGNSEVAGKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL9</accession>
    <name>A0A061DCL9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0403500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770048.1">
        <property type="nucleotide sequence ID" value="XM_012914594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCL9"/>
    <dbReference type="GeneID" id="24566403"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403500"/>
    <dbReference type="OrthoDB" id="366388at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="477"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="762" mass="82463" checksum="88532A29C3280549" modified="2014-09-03" version="1">MYDPSGNYNSSYSPYGVSGNESFSHHAPTGVYSLGTSSMESNGSIGNLLKCIKTWQGNAEGSISSGGSVKDTYDNFGLLRADSLGVMSPAMAPCYSSPSALQPSFPVALGCHPAPRMRSNGHLGHAAPAVCDYPLQDQQQQVQMHVRPQLQLPEQSGEYDGSLDVRPVLCIDGSAQSQPFYSQNRHSSPVCVPEGHCSQGAHSETYSSHAQPQALATMQCQMSPHCVHRSPVALPSPGHVNSGSPFAEPIHPSRVGKRRAPLADHSVDARAIYHDVGDGSGSTVLVPCYPALETDAPVAKRAFVSNPSYMHPDYDQHHSSPLTKRPTYGLAMPRPVPGACRTDQMAHLYADADDIKSGPRLVYVGNVDVLGNDRIADGESNPFLDAGARVVPNAIITPRDILVYGRRGSFTYGDRPFSPDSDPRAASLLKNITVNCQYGRVRPAETAPPQPRVVLNGRSTGLLEADKYAIMATQVEKVRGVCYCRSDNSWTAWWTEKGRNRKKAFKVSRHGFYEARAMAIEHRRAIGKDGVYRPTVQPYDGTGEGAKRVATEPVVSEVTPEVSTSAATPTSVMSPVTLPAGVVTAVKRMNTTPRQNERTFQMAVTDVESPVVRNRPVDHSSTENADEFNQETAPTPTLDSCDSNAIKAFDGQNYCNTEVHTPVRTLKEHTGAAAWVPGKEGEKLDEMFKRRVMSACTTADSTEFVGAKTEELTPNMVSLHHDISDMLKLDEASVRNVKMAISSLAYGVEDSRLPAEPRANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCS2</accession>
    <name>A0A061DCS2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0208890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767921.1">
        <property type="nucleotide sequence ID" value="XM_012912467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCS2"/>
    <dbReference type="STRING" id="5866.A0A061DCS2"/>
    <dbReference type="GeneID" id="24564276"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208890"/>
    <dbReference type="OMA" id="VNCIALG"/>
    <dbReference type="OrthoDB" id="361983at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="3">
        <location>
            <begin position="193"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="531" mass="56777" checksum="3F68B0A2EE898BAC" modified="2014-09-03" version="1">MPSDDSSVSTQAPPGDLGEVGGAAVAPSRLRPVAGRIFSRAATLSKVDGLSDSVLEGLNSWYQEEWRVVHASRFAICPQLTDSLKRHFASRSSPSLTAESVESFLRTMSLLYYGLRSDSSPSGDVSKNKFFQRYYYTSRENAAALNSPIVMSNFVWACHRYMRDEFANTCLLDILLQAFPAALESFVRFGGVVYLKSALDYLAASGKLRSSTNYLLKALALLNKLDISFRTLQTSRIGIPINGIATGGKNVKMGIDYECENDNVKLKATDLIKKWKAIRDASQPMKVEPDPRRQVRRTPPAQANPAVPAPARPAQVTAVAERKADAPASRRPEPAPAPGSFVLNILDSMVEQREKERKRKLAMKEAQRNGLFKVSRVSESEGTSRPEEAPPAASVQPGAAPSNPPGAEGGTGGGEDKVAESRKELQSLMNFFKSFKPQIAPPHSSGESPQSSSSDAPVSSLPSASSSAPHSGDRTGLSVSSNHITHMNGVAAGTNSPRPAAPPPPPPSFHLGAAAASGSGSMPPVCVPPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCV9</accession>
    <name>A0A061DCV9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">-Lysophospholipid acyltransferase LPCAT4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0405170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770218.1">
        <property type="nucleotide sequence ID" value="XM_012914764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCV9"/>
    <dbReference type="STRING" id="5866.A0A061DCV9"/>
    <dbReference type="GeneID" id="24566573"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405170"/>
    <dbReference type="OrthoDB" id="365623at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF52">
        <property type="entry name" value="LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR98032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="174" mass="19865" checksum="A7B557E8930FE132" modified="2014-09-03" version="1">MRSINEGREKVSLVVYPEGTTCKGSVLLPFKHGAFGALVPLHPLLVVLEYSYLDIAYDVFSWQWWTIHACCSPASVRLIAYWLPAIQPPTEEEVARKGAHECVREYAIYANRVMREAIAKLNPHADLEHLQKRDVIVSPTLRGKLTARLYGPVMQRHYELTDAEVHKTEEVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCW8</accession>
    <name>A0A061DCW8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0405360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770238.1">
        <property type="nucleotide sequence ID" value="XM_012914784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCW8"/>
    <dbReference type="STRING" id="5866.A0A061DCW8"/>
    <dbReference type="GeneID" id="24566593"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405360"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596225" description="aspartate--tRNA ligase" evidence="12">
        <location>
            <begin position="28"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="276"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR98052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="588" mass="67387" checksum="B441AC5813BA54F9" modified="2014-09-03" version="1">MGHGRRPLTLLFLHSVRLLLLRGFCTAGAVHHPSRYYGTGFLHRNLSHIPNLHSLNMDKRQDNIEAAPVPPANPKEDAKQARLRAREEQERQKLLLLETTVSDLDSTSFGYLSPTLTSLPARNWVDIKDVDDAKDQLVWIRGRINDVRGKGAMCFIILRQQYQSLQCIVDSRQEMVSKDMVKWSASLSMESIVDVFGKVVVPDVPVASTTAKCELQVHKIFCVSKATPTMPFLIRDANNTDDEEACKNPNVIKVNQDTRLDNRPLDLRATLNLAIFKIQSEICQQFRNFLIERQFIEIHSPKLLGGTSEGGCNVFKLKYFDNDACLAQSPQLYKQLAVVGDFRRVFEIGPVFRAENSNTHRHLCEFVGLDMEMEFKDSYMEVVDMIDDMLKSIFEGVTKQRKEEMEIFGKMHPSVEPLKWLEQTPRLRFTEAVEMLRGTELASEIPDDISSYDFSTEQEKRLGRLVREKYNTDYYIIYEYPLNARPFYTMPLERDGMMFTHSYDFFMRGEEILSGAQRIHNPELLLRRAKECGIDPKTISSYIEAFKMGVSPHAGCGIGLERVAMLLLGTGNIRKTSLFPRDPRRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY1</accession>
    <name>A0A061DCY1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VOLTAGE-GATED CATION CHANNEL (CALCIUM AND SODIUM), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0308720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769155.1">
        <property type="nucleotide sequence ID" value="XM_012913701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCY1"/>
    <dbReference type="STRING" id="5866.A0A061DCY1"/>
    <dbReference type="GeneID" id="24565510"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308720"/>
    <dbReference type="OMA" id="ACERMNG"/>
    <dbReference type="OrthoDB" id="431647at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF62">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN 60E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="97"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="716" mass="78665" checksum="B3A2E426A5045E9F" modified="2014-09-03" version="1">MVTTAGNSMGGGAGDLAAGESLPLNMRLAAASRATPVREGLPGGNSFGETAAISSSVTSYPPLRYCGSGVVDARKYREELLMITRNHEDMGKRMYTHPYYKWFLMGIVVGYSCFLGFCTLLDWHDFSTPWVTTIFVFRFLFFVVFTFDLIMQSTQDMNIKIYRNPEFLVDLALLICEAASTIYVAHAVLNHCSSLPVVVDKCQQDLNNLRIWSCIPLLRLYKLCMHCGPLRTLTKGILLSIQSLAWTAVFVVMVIYACAIYTTWVFTEVKDDEMDDYWGTLLRSMYTLFTIMTLEGWNQVSNDTAKFYPNSKLFFVIFVCFATLTVMNVVTGIILNTFLTVNEKFSEEKCSKGRCDRYAEVTSILGEAIKGAPSGEQACMSREATSQFVSARTCSKDTMEEHTAASDISNAGNQRMKGEGDKLASKMMKVGQSIGLKMRNTMWRIMPALARSREEITGEIIFGDIERGDADDHNNAPAGGTQSLNLPEPLTPTNARGGATVLQDGTSPSTSRKPTASEILNDLMDAVETSPSGELSTLTAHLPVRSPGAPAPQPAANNSIQGACKVNMSGDMRSNDCVVYGYRNEGEVGSTEMLRFVAAQTGDHAVIDMTFRDPYATLTDPSIKQALRHAGVPMFQAYEVLNMYYANGLYQVTVSEFAAACERLPGNTSGKDLLSFELAFARRLSVLEARIAQVGSKLDLLLEYFANSAVAPGNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD12</accession>
    <name>A0A061DD12_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0210130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768046.1">
        <property type="nucleotide sequence ID" value="XM_012912592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD12"/>
    <dbReference type="STRING" id="5866.A0A061DD12"/>
    <dbReference type="GeneID" id="24564401"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210130"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="61"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="412" mass="44576" checksum="A2D608BFC4C88C95" modified="2014-09-03" version="1">MAQLQTFFSGCAAVNTLVRRFARNAVVLQRNACAATLGDRHIGLPAFGARQLHASARLLEVKTMMLPSLGDSISEGTLSEWKKAVGDAIAMDEPLAIVETDKVTVDINSTMEGVIVKQHYAEEDTVFVGKPFIDVDTGAQAGSAGVPESAQEKKVAAPEEVAAKEAKAEEPVAESKPVEEAPTETRSQVQMTRMRKRIGERLKESQQTTVMLTTFNECDMGAIMELRKELNESGKFPVKLGFVSAYLKAATMALQKMPIMNSYIEGDDIVTKHFVDISVAVATPTGLVVPVIRNCEGKSWAELEQQLADAAKKGREGRLTVADMTGGTFTISNGGVYGSVLSTPIINPPQSSILGMHSIIKRCVVRDDAMAIRPIMNLALSYDHRLIDGREAVQFLIAIREAIEDPSTLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD75</accession>
    <name>A0A061DD75_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0211640</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768206.1">
        <property type="nucleotide sequence ID" value="XM_012912752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD75"/>
    <dbReference type="STRING" id="5866.A0A061DD75"/>
    <dbReference type="GeneID" id="24564561"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211640"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="10277" checksum="FBE071659A18F273" modified="2014-09-03" version="1">MVGRKDKLQQIMTQPINQIFRFFTSGTRVQIWLFDQPNMKIEGRIRGFDEYMNMVLDDVEEISVKQKVRRALGTILLKGEAMTLIAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDG5</accession>
    <name>A0A061DDG5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769565.1">
        <property type="nucleotide sequence ID" value="XM_012914111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDG5"/>
    <dbReference type="GeneID" id="24565920"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312820"/>
    <dbReference type="OrthoDB" id="366620at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="238" mass="26800" checksum="10FE01458D98B609" modified="2014-09-03" version="1">MVYNSLADNPWNLKEAIDWLVALKGTDPSTNFKAMGAALYDFLGQKPIVTRSVTTIEELKRVSYRFIGQKELKHHRSSSVMLERCNGSVEKNTGEFADAMGSKPEKVADNVANVVYACEKFLYALRRHGEHTSAYSSEATWARSCSNDPEACAKIFVGIAPMLYTRLLTLTDASKATNSVWSWFEERQRVVDVLAAGGYTKWDCRHDMSFFDLSKVLSSIKKETFIMLYNIAGVLAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH9</accession>
    <name>A0A061DDH9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768466.1">
        <property type="nucleotide sequence ID" value="XM_012913012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH9"/>
    <dbReference type="GeneID" id="24564821"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301840"/>
    <dbReference type="OMA" id="WIPREFV"/>
    <dbReference type="OrthoDB" id="366852at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="398" mass="43765" checksum="B3FE4C5E13D39C70" modified="2014-09-03" version="1">MIRKYLSRPANKRPNYSLIGVDKPFGLPNFGAADVEVCHPSDGCAAAPASKDSTRASNAVYMQERRANVKGASNAAAATNGRVALAKDDKSYQDVHMTTPSNEALVPYRHDLPEEWIPREFVGRLEGSYMQSRHLLLSCITAGLHRDDVDEDQSLQVLRVNCFPYSASNQHLKHLLDTCVFSGHCSTPPIDSHLLLSCCVKVAGRGSICAGSRIYLPTQLDLDANHQFVGMVVLGRFPSPVSRCIGGNDSASKLTPISAPLRGRDFKPPEALKEPPHDEYKLVNLKRLFVCSGRRRRVGIETAVSGLRELDTCRRKPLRACIGAVTSRGFSHKGNCIVQLRAFVELMRSSIAPKQRTDANIELLQSLRLFVWLRNNNSADYVPGILSVAFHDNAGSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDM8</accession>
    <name>A0A061DDM8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartyl protease family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0302990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768581.1">
        <property type="nucleotide sequence ID" value="XM_012913127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDM8"/>
    <dbReference type="STRING" id="5866.A0A061DDM8"/>
    <dbReference type="GeneID" id="24564936"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302990"/>
    <dbReference type="OMA" id="HEANGYH"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600299" evidence="5">
        <location>
            <begin position="41"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="511" mass="56628" checksum="F4A93767D2EDD167" modified="2014-09-03" version="1">MSLGISNLMAVTYKKKRLSAVPVSLAILLLLYIHLPPVVAACSTCNRDETFDKCVEQRRLDHAVHEDADTKCELSKPIHVMLYGNLQELAYYYTVVEVGTPPQSQEVVVDTGSANLVLADSECRHCGHHDMKPFNTTLSRTLSYIDGNSSRCAALGGASGQNGAIKDACVFAEEYEEQSAISGFYATDYFAFKTDTDTNATYMLPQLGCTISETKLIYQQRANGVLGLGPAMVSSDDSSEASQSRLEKTPKANELKEVSNVKYGNFVDDFLQNNFAKTRHRFELCLSEDGGSLVFGGLEESVTDNEDPDILEQDRSVDGPLLWMPLMRRGAYAIVVNAVTFCGTTIQPANRRFILDSGSTNSSLEQPIYSVIYGYYMSLCNSMNRNAEVVRHRTTRRLYSRKGTLRRFIRRQLLFKSADEKDQNVFSKAIRTSAGDDDDTHLHSADNGGEVYDAGDARGDSTDSECTVKSKSLSKGRCVIQKKHGYLCFSDISQMPNVDLIIQGYVLRCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDQ0</accession>
    <name>A0A061DDQ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768641.1">
        <property type="nucleotide sequence ID" value="XM_012913187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDQ0"/>
    <dbReference type="STRING" id="5866.A0A061DDQ0"/>
    <dbReference type="GeneID" id="24564996"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303590"/>
    <dbReference type="OMA" id="RWLNNVK"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="27916" checksum="B6E70B8BC3E1B0BF" modified="2014-09-03" version="1">MTARGAIFRGLRRFSSVSCLGIRASQFGRFQPSLCATALRQSTRTFSAESEKLRQLVQGEIQHENSNYESPANIKTFLEKNEWKFIEKEGDVNMTLEKTVDGKKVTVDFQLVSPFETEGEGETQAEMTDFSVTVEKSGGQGITFYCSTLQNDDKFRYMICNVRFFSDEASKNSVSRFASSFHTRQVSTYNGPDFEDLDDSLQATLDEWLGSLGVDGELCDFIDSCSIDKEQREYIFWLKGLEKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE54</accession>
    <name>A0A061DE54_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0307390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769021.1">
        <property type="nucleotide sequence ID" value="XM_012913567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE54"/>
    <dbReference type="GeneID" id="24565376"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307390"/>
    <dbReference type="OMA" id="CYFLRRY"/>
    <dbReference type="OrthoDB" id="364926at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="436" mass="48778" checksum="B913D0110C482201" modified="2014-09-03" version="1">MRVPNASPCGIVTNFETRCSDHFHPSVLAYVLRNRAAHVARNSRGALPQRLRDELWQIGASAVSASSHLEPQTAATLLLSLAKLSVTLPDTIKALTSDFKFQRSHPKAIALTLNAFARHPRALQYVPGSFWAGVAEAVKRLDAQFSPQDAAGCALSITGLLAANRYRSADATGACNTPNGIDLIDRQSSQKLKATQAQVLSYAERMMRQLDMFAFQTRDLSCILRAVYASKVEAPSLIIATLSRLKEAIPTSLNGIDDAIYTLDLLPPPDFAADTVEKRRVKRDVARAEKAFVEWVFEYLEEHLDCLKDRELARLAAACNRLRSWSNDQFAIKFAQRWQETLRSMEVMPAKYLAHGVCYFLRRYEASVTRELANKGTEEQQRIAQVSDLCARVGEMLYDHAATHYSPEDLRRVEELVHVAEQCRAKRKSSQTIART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE65</accession>
    <name>A0A061DE65_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769051.1">
        <property type="nucleotide sequence ID" value="XM_012913597.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DE65"/>
    <dbReference type="GeneID" id="24565406"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307690"/>
    <dbReference type="OrthoDB" id="365890at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1588"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1662" mass="180584" checksum="7282D7A3A490DE6A" modified="2014-09-03" version="1">MAAKGAAGGTAHGVPLDTLKDCLQFLEWLNGRNGQRSHVVTGIVQELRPYYGSNSQFKGQLQNRYVNFIKNVDSLHKKLSFNVGTTLRPYEVTLRDPKLILDALLECTPKLLAALSFIQYHVDGAFSGVGGGDWASQSPNSGDFRTFLTTGNYILRGGFSDKELSSVQGSTLVEDLKTILNKYGARGHPVHDHFRNVMLITLARPLDPVNTGNAVFLLPVFCELVIGDPDGNKYKSSVEKAIGTNTICWTDLKDHCQLLKEHIDQLTAAGFSATGIAFKPKEPVKFVTKAAEWCKANLSKTASELGKMIPQSIYSRSTELQPFANDKLYPHGFIFDGSKQRVWAKPSKLDEWGPIFQKFIQLDVLLRKLKDILDGYECGAAPLVTNARAVEPTATKTEATKTEAAKPVVTKADATKPVLKNAGSSPNQNNGQSERKPTTSSVVTSSSKHPGGTGAPGSTGAKGEKGPLGHPSTVYTTSFPPQNNVQRQSPAQPPPATPPRAPAGPASPSKPDGGGKGSQGDSAGPQPTSSTSSVQPQSPGVQPPGPQSPGASSNGGGTGLDGKVPISTTQRSGQDTSQTSTTAAGTTSSGSSSGAGGGGGSSQINGAPGSQPDASSEATITQLSSVQSPDSVPSGATGSDSGPDRGVQRSAADPIQQHTQVNPTGTGIVSTASAATDSTSTAVGSGDGAGMGGRGAGNGQPQTTVAIKKNAPACDANFLMNYKSDAEPPCQVISNLRSRTSPPTSYPAFDRAWEKVQENELQRKLDAKRRQQVAQLGRHTPIRHVQRPTGPSSLPSGGHTVNQRPYFVPGGGPSRQVSETLHVDLPSLEVSGDVVDSKPSKEIEDKLRRKLKAEEQVKLWQWQAKKEGDSYDKKLLKSDIYVYGSEVADTGTSVLGDSDVGLKGEFKGTPLPHNSDHLLPKQHAADRYKSYLQHGTISDGYAIRPPKTQRRTVHPLKPPKQYPTAQPTSNKPKSLLNPYDLSGIVLEPNQQGKKNVHGITGQQTKDNNMPLPLSFFMADGKPVAKPPSEKWKPKTVEPNDIYTMLEKDVQGNVLPAIPDILSKPIPDPKRNMRMPKLDNDKRYTAHTGKKDFVQRKSQSQIGYFDDHPGVMIDPGICPASYGNYVLPVGVTIPPTDSFNPPPRTVRQMLCWLSDLPSAPSFAVLTQLVASLFDSSHNIVASETFSDNDVISSMYDACGHASSVLGGIQGSSPADMSKFHFERYGVALMHYSEDPYTLLCQLLSYVYAAYHQLSFLRTQCSRDTHSGGWRDCQYGKNVNFSETWQCTKFPADIVKSHHHGCDPSPLQGFLTDHLDLSTYRYERDNMCRRSHIKMGFQHTDLQSKSMHGFYIYQLLIGACYTSDPLENLCRYLVCLTRRTPRTTGELVSYFHHFGIELHGYASDGLSPLGTALTKSYVDCPDWDHLGRHDLVAVKGIRGSESLISKNNSSHDNAHPRTLSTLVGCSGDPANCHPRISPITYRAYALYSQSFAHTYLSWAVYLPDRLHESLQKLYYELKKHDSSKCSSLHLCSTALPLLYLHGFTPPEGKSQPTVTCSDVITKLQEIVNGRPIADFISAMDNFLYGIREPFIFTIVALWSLAFLIFANTMLYRLDVLRIRSHLIRTKASHHIDVKALLTKGRKMLSLYKDVDYFDEDPIGQLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE74</accession>
    <name>A0A061DE74_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEAD/DEAH box helicase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0307940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769076.1">
        <property type="nucleotide sequence ID" value="XM_012913622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE74"/>
    <dbReference type="STRING" id="5866.A0A061DE74"/>
    <dbReference type="GeneID" id="24565431"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307940"/>
    <dbReference type="OMA" id="GMPYPKQ"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="8">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="97"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="289"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="479" mass="53509" checksum="25F201BEF45CDDD0" modified="2014-09-03" version="1">MGQDKVKRDVQEQEASSWVLEDVNSKPLQLVAEVKPRKKLHVHKEAKVSNTDEEKLVVHDAKVVGKTFKELGVPEWLIDLAASLRITTPTKIQELCLPAALKGDNVIGCAQTGTGKTICFCWPILIALSKDPYGVFGLVLTGSRELAFQIGDQFNIFGVQMNIKICVCVGGVDIVQQSLELEARPHVVIATPGRLAEQVDVKERNIAKVFAKVKYLVFDEADILLHQSFEAPLQKVISCLPSTKEGRITYLFSATITKAIRALCDSFKGVQFHFFDVTKGQEASFRDLELKQHYLFLPQHVHLPYLVHILQTQLLENETDQGIIFTATKRRCQLVAVALDLLDFKATCIHSLMKQRKRNACLAKFRTGVSKILVATDLVARGIDIQAVSFVVNLDFPGTTEDYIHRVGRTARSGKSGVAISFIDEDDVEKLKKVEEDAKVTLTKLEVDDSQAVKLLNKVSIATQRARVYLQENNYLQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA6</accession>
    <name>A0A061DEA6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770295.1">
        <property type="nucleotide sequence ID" value="XM_012914841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA6"/>
    <dbReference type="GeneID" id="24566650"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405930"/>
    <dbReference type="OMA" id="LAYAECV"/>
    <dbReference type="OrthoDB" id="360811at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="352" mass="39692" checksum="01B0D5F699531D57" modified="2014-09-03" version="1">MYAALLPAFAEPPVLQFENYIAQNILDKILHEKNLTIPLEEADYLPPDFAPGTSDVRCRRVLTRHYQGFLYALVENSGCSIESVADVPLDDLSGHLFGPLGDRTIDTTANKTNARTPASCIQAKIQAKCPVYLAYAECVFTKYMSFGKTNAKLTLPKRPSIDQTFGARFLEYIEGIAKNVPRLIDETVTHLCRFVNTACGSLNPQFEDTLSFRLQHVCSLFDVFTPLADYSTMYSPELSEEQRLEISELDREMREAMFYAPIENVFFSPLGVPYDTSINAKHILDAYFDKLCQKRCDYITTMLNISSDWTKLSVLGQQQQMLICAKLVVTCNGCQSCEKMGIKVRNDDIIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEK2</accession>
    <name>A0A061DEK2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BETA-TUBULIN COFACTOR D, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769611.1">
        <property type="nucleotide sequence ID" value="XM_012914157.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DEK2"/>
    <dbReference type="GeneID" id="24565966"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313270"/>
    <dbReference type="OMA" id="NCRRAAC"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="2">
        <location>
            <begin position="469"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1539" mass="169446" checksum="7EE3B28CC3F87C59" modified="2014-09-03" version="1">MEFDHVQHTLVYFSESEEAARLVKDLDSYCRFLLLGGSAPSSLGKGTAAGGATAAEAYGRRADSIESDAGANTGTLSAYTPNALQCVVKSRSLSISSAEPECQRGTALSSLVTVTSDLEELVGRYMHSPTLLYPHIEALVSTAFDLLRGFVELPFEVCAEVLSCGPSDEKRDSLISLEFVCYHIYNVAKVVGLRRVVGCAPNEVRFLVPLVVLIEYLQSHGRIGGDMKYDNKRWCMEYVCLAWLSLLVYTPFDLGTIWHAGDGSGITLQGRILGVSMHYLVLSTKARDAAAIVLSTLFARPDVSDVEVDRFMSHCTYVLTSGSSANLPGSQSTSGAKKPSGAAAADANGNIVPSPGRGGAQATPAASPDSGDDLFASPTLPSTRIDAAVNMGDSAVQDASTAPSSPDRPVAHLGSNDHGQIGVMTVLKQMLKRMSRDDLRLHLPRFTACLLDQSWSPSSSACRKLKAACLGRLAVHLLPPHSSSQRYRRLCRKFMESDSVPEEPESGDVDFEMDERVEGIVEQLLGTLVDSDIRVRWASAKSIGRISAKLPMCFNDQIIEHVLQIIQNQYDTVRHCFTKGEAPVHGSCLAIAEIIRGGILHPHMLDRVLDCVVLTLDFDVWRGKGSAGTAVRDASCYICWAIVRNFASTLIQPSHLIPMSKSLVNMALFDISINCRRAACAALQELVGRVGNVAHGLDLIVLADYYTVSNRRNAFVNVSFAISKLGFYTISMIDNLMKTKLHHPDITTRRYAATALGRISLALIDSPNSQLATRNGRPVYLEIVEHCLANVFSTTLGVMHGSLCALTEVLLGLLNHGVLISDQFSSIKQIPVLFERKRLFRLKGGVLIRQSMCRLINFICRIVRLNDCLSIGPNELDVYIVIVKDCVRSFTLDVQISAAECLSEIFEMLCIMDYPKATCMMDYLLHSLANHNDNIAARRGYALALGSVPERLCEANCESLLEALCQEVLTNSGNSAIKDAQTRQHAIISLVRLLKLCAKVKLSAPIIERIVSSLEFGCCDSEVDSRGDVGSWVREVSIEVIAYIFFLKQCKVLQQEDHGMLHKLSDAHVQRLVKCLVGVCLEPMDHTRARATFLFAHIFGATFHFKVEWVWQRVFYGARYEYEIARRGTFPVSCMDTASAVEHVSKCLFAGELRPTQSDPGLYPRASDHNSTSRHPLPAVQSCSDICTDSDYAAGMESDSANSDSASHMSQDDNLEGVNVFRTAADSAIKRAIFRGFGTSYSCDHDRFFDDCAFMSGPEAPVISAIAHNINWQVVHTFDLQELVLSLSSDSMEGSDAPPKAQGNISLRLPGYALSPLCFDQFMWMLYLPSFSSVVMRALFQVLGGMAIQETWNRRTVSDVIIEFIRAHQRQIVRAPHGDWVELHELLLRYVLEVYREGIRDKNYKLSTRVVSAARTFLLHRLIVPTTEMVDLLAKEAGTATNYGYLKSIYKCLHAAHSTIRDRRAARTALRAMLGYICHKYPTLRTYARSSLMAILSSYDWAPSTDTLGAALAMLDECVANKGNEEALLLQRLLSLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEP6</accession>
    <name>A0A061DEP6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769831.1">
        <property type="nucleotide sequence ID" value="XM_012914377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEP6"/>
    <dbReference type="GeneID" id="24566186"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401370"/>
    <dbReference type="OrthoDB" id="330669at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="475" mass="53544" checksum="9E75C0F2573F1D42" modified="2014-09-03" version="1">MHEDVIGFLSRLVPRRTATLYFIFFVSTLLLSIGLLNGSENLFRSFTSCRGEAEYNISAFTALVVLQCILLLPKSDESAGDHGETSGVTTRSLRRMDRDGAQFPSKNLGDNLDFANRSCFSNEGFVSIICEKFSPRTPPLTSSRVAGGPGSKRSLTSCGTNDKNDRSTTLDRRMCKSVPAYEEQTSMDDRAHADNAGDASTNEASDADKDHDEIPSDENDDVAPNPCAAWMYSCSICWNSLWMSLYHFVSFMGIHATLLASRIHGTIELNKHALETCVHLRDKFPLHMWSPRLGYQLISESTFFLTYMSCTSLELVIRKYDDASYLKNFFTGHFLKERRCLGIMRILLQAVIFLYAFVVILASIFTGYGSPMQILCGFSMGMLMLWINSLLTQLLQLSDMSKSTLDFNWLWSLLSLLNFWICGVLFYVSVYGIPLSAPYIYLQVASWIPLLILTTRKGKQIFMWQDISSALYTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES0</accession>
    <name>A0A061DES0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol-4-phosphate 5-kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769951.1">
        <property type="nucleotide sequence ID" value="XM_012914497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES0"/>
    <dbReference type="STRING" id="5866.A0A061DES0"/>
    <dbReference type="GeneID" id="24566306"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402530"/>
    <dbReference type="OMA" id="EMYEGYW"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="395" mass="44524" checksum="9FB9F9604B35D4C5" modified="2014-09-03" version="1">MAVAYPKSLQSALSSVPDTDNRANSYTGQVQDGLFHGKGIFYYGDNERYEGDFVYGKREGKGKFYYADGSIYDGDWVDDRIKGKGVAYFASGNVYEGQWENGRINGYGTLKYVNGDEYEGEWIDGAMHGQGTYRYAEGDVYTGEWRNDKRHGKGTVTYVSAKGAVLESYEGDWVDNVMSGKGKYEYADGSIYEGDWYNGKMHGNGKYTYPDGNKYDGEWSNDHKEGYGILMYTNGEKYEGYWLNDKAHGTGTLTYPSNDKYVGEWVNSKKHGCGELIYVNGDRFKGTWADDEASGYGIFEYANGNRYEGKSICNNVIIYEIGDWLMNKRHGKATFYCHEDGCVYKGGYVENKKEGLGTLTLTNGHILRGTWRRGTLVSIEKFDISPTSCWSNPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEU8</accession>
    <name>A0A061DEU8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770091.1">
        <property type="nucleotide sequence ID" value="XM_012914637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566446"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403930"/>
    <dbReference type="OMA" id="CETMDTA"/>
    <dbReference type="OrthoDB" id="10540797at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1640"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1678"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1715"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1827"/>
            <end position="1836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1860" mass="193120" checksum="7EFDE13CC572EDA3" modified="2014-09-03" version="1">MEQSRASLIRSLESEDRYVYELHKRRHRQATSCPPIYYEDATRISLELDAVRTVRSILQLKDSGEMGYPLRPFVLPCGVRQECSSGTSTSESCSSLLSTRIDLRSPPFFPAKGKGSQDVAIGHCEVSVDITCLTEMPPNVNKHASLPAKCGSNITAERISPNGSSSDGSITQNDDGDASRFSKHADAVKPQLAKEDNAHVDRDMRAPFAADSLPTLASQPRGEPHTCNKAEEATSEGKDPIYVATCTNVAAGADVTVETPIEIPGPDDATQIRVEDESDSSPATEAMHENQHPEMDEVYTTVKPLLQAEDTPPSASELLDSPSESETGSDSSVSASPKHSSRSLPCDTATHDEPLSQQQSLELSENTAASTDRDAYANDSPATEAVTPPISMRTEKLNETGSTYQHDTVEISEPDITSSRTESNALLSETDSSELGAENDLASDVEHSIDSVDVHNGDDDVAKSSTPNDESAEPKLVNRAADSGRGSPAPCSASSVSVGATNNSDGASNSTSPKLQSVTTSVDSPPLSSGRPGSDAMASAPPTLTSVDSYIVSDPASERASARSVGSEGHRPSPRLENPEHQEVVGMVEDTPHTTESKMTEEATTVETAGASNDPAPTHDIKEGNSSADEIEATPAESSLVTPRSVSLSAADNVDADSSIEGSSDQGGALQSDLASDTDEYESDSQLPMTPQLSSHLGDDEEGESVTSSPHVATFGDVQLSPEPVEMIQPSSEAEDNVESSMEAADDSVANMPTEVEEDVQMPTGTADESVAESSSEMTEEDVQRPTGTAAESVVPPSAENADQNVAATPADGGEIVIESPTSNAGDDMDLSMGSVEGANDQQNTDNVEDGVMEMPAEPAENVTETPIGSEYVVQPSSNTFDADVPDTPTETVVDDVLTSTETAEQVDTQPPAGTTDVNIADSAGNATQQPASTADILITQPSVDEAEDATLTCADTVGDAVAEISADTSDGNVRGSTTEAEDADDTEASDDTVDEDDVQMSKDTEDAENAQLPTDAIEADDIQISAVSGESNASAAISEEEADCVSAEACGDACQAVDDASTQSIRDFVIPAIHTSTPSRKASIVSHDYVGVPEVSVSDKGTPRHVQNDPSVADISRYPSLPSDGVKADAPSSSSSAEADASLPSNNENVGDLSSRCSSLASGESSVRAAESPISYRHEDTLSEMEESSSSMIATDAADVANSTVTAEDAEIPKVDTSPENSPFRVPHEVEDKNLELESNAASSELGKVDERISDTPSSPRITEQLTQDVEDAAEGIEDNVQSRSSSDVSDADVEQSEPSHLSQYCGTPTTPDADPAIGTASDDQIGVCGDPQPPEDKVVCPSVNAVDTSGSPSEATSPRSVVGECSSNEVESGNSEEETAVSKECPAVADDSSTSVLTGEMKLLHTIRTDQPEDAGNGDEDPLVPTSDSADVPMLADDNALKSGEGGSLTTVNISSDTESSSSNVQIDESTPLNGDSDDNATESKFSDVLKAEPSEGSDDIPSAVVSGESSHPTPRSADSLASDSHSQSESEASAPPPPSESTPVSEGVTDLVGEHEVSVERTASYCDISDDVRVSPSAVPESTTVEIGAISGDNQDAASTDAEHALSADANRLSTPGAPVEQAPVAETIPEIADSHSVATPRSPSPTSGVVQEEGSEDGRSSAAEDAADDTGILSSAISESESVASPLLSESPRSDATPQLESDYATDNGISYSDSSPFSAESSDVHSLGSSPREYGDGELADGMPKKAKTNVKVGDASDASADLSPNDGAEYHTDALVTDEEEESHQSSASLLDSDNGDGAGHSPPAAVPHGRLAVSRAGEPASISRASSSSTIDANLPNQEEAETNYASYLMSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYE1</accession>
    <name>A0A061CYE1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 70, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765867.1">
        <property type="nucleotide sequence ID" value="XM_012910413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYE1"/>
    <dbReference type="STRING" id="5866.A0A061CYE1"/>
    <dbReference type="GeneID" id="24562222"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100100"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000001">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="654" mass="71466" checksum="7838B0B7478B6B0C" modified="2014-09-03" version="1">MSFLSRLFAFGSPAYRNVLAHRKLTTSRLLRSKVQGDVVGIDLGTTNSCVAVMEGSHPKVIENSEGMRTTPSVVAFTDDGQRLVGVVAKRQAVTNPENTVFATKRFIGRRFDDDVTKKEQKTLPYKIVRASNGDAWIEAQGKQYSPSQIGACILSKMKETAESHLGRKVGKAVITVPAYFNDSQRQATKDAGKIAGLDVLRIINEPTAAALAFGLEKNDGKTIAVYDLGGGTFDISILEILGGVFEVKATNGNTSLGGEDFDQRILQYLIAEFKKQQGIDLTNDKLALQRLREAAESAKVELSSKTQTEINLPFITADMTGPKHMQFKLTRAKLEEICDDLLKGTIEPCEKCLKDAGIGAKDLNDIILVGGMTRMPRVSDIVQRIFGKEASKSVNPDEAVAMGAAIQAGVLKGEIKDLLLLDVCPLSLGIETLGGVFTRLINRNTTIPTKKSQVFSTAADNQTQVGIKVYQGERGMAADNQLLGQFELVGIPPAPRGVPQIEVTFDVDANGIMNISAVDKSTGRKQEITIQSSGGLSDEQVERMVKDAEAFKQSDEQRKQLVDARNDAETLCYSVEKQLSDFKDKISEDDKKALEEQLSELRQQMSSEDLDRLKDSHKRLQELSWKVSQQMYQSNQQSGDKGSSEGDAGSENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ32</accession>
    <name>A0A061CZ32_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765894.1">
        <property type="nucleotide sequence ID" value="XM_012910440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ32"/>
    <dbReference type="GeneID" id="24562249"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100370"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595592" evidence="1">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="77" mass="8405" checksum="DB342A08C2BAFE3C" modified="2014-09-03" version="1">MRVLTFMATVVISPEVVTPDCTPAEVLRVPANMATHLFVTPKGLQREWAQCQSESGIHIPHSLSGSDCNLMEIMLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ36</accession>
    <name>A0A061CZ36_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0102150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766072.1">
        <property type="nucleotide sequence ID" value="XM_012910618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ36"/>
    <dbReference type="STRING" id="5866.A0A061CZ36"/>
    <dbReference type="GeneID" id="24562427"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102150"/>
    <dbReference type="OMA" id="RNTHETP"/>
    <dbReference type="OrthoDB" id="366244at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="850"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="7">
        <location>
            <begin position="1026"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1156"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1191" mass="130920" checksum="186B6F7312B76F0F" modified="2014-09-03" version="1">MGVWAHVDIAITCTELHGVALQDSTWYRLGFRVYKQHIAALLVNPSAPALGPTSLPADLPECLVPLIAVAADDDAYVTRPFFVKSRHHRVTVNEVARFRAELPAIPSVLASSALYVEATLVSFPVTENGAIVSKETGGNNGLPTVVDAKAFRVGNLAQAAREYYPCNFDGEHLNAVAHLTVRTAVTKLGIAAPLSLPLSTEPCQHYLEWRHMLKKSGNKLVKKWFMQSNKHEEAFYDSPKPATGGRRWLLHHSSATDFREPNVTAKKAELAINTFIAQVVAGDHGCGAAFGLEWEPEAPLAESADAKSGDPAPYDDATFSMGARMLIYIYAKILADTAVALDRALPVRHPEGALEAASSSANAANPDNSATNENSFANTNAHIERNCAHNTTILGYPGSDGAVVSFTDGEVKQEDGALRNTHETPNAAGALFQPRSASTLHVAICQRLNRIADLLGIRKCGEKKLSITVRHGVTVVLDDVEGYSVPQAATGTALAHTMSKMFFGLCTWICLTWDRVVADVQCDAQDRRRYVDAYVKEQLRVFKRMGDPALDQTALVALLRSMRITDEHHFFIADNFPFMRHTPVPPRNAEAAAEPANHAGVHLVVLVHGYNGYPVTMRFVRNTLLAFTSNTEVIVSRFLYENPESSIEHKASLLAQEIDIHVRRNALTRKLGRLSFVTHSMGGLVVRAALRHLGPYREKVHALVTLACPHIGVPRMPSKLLEKGCCLLASYMRSACLNQLLLTDGPSRDTCYLYELSGDDGVRLFRKVKLVGILQDHVSLAYSCLLEPSLANTRSATVESMCHRISERLSGAQLDKFCIDYGRASRYVRWKSIDAHLHIIDYAPLARHFNIPVEGQKLFIDGRALENAEQTMQEACVKHGDVVYVGYAPAVPLTPGLMRSRQMSQIDNDRASTIMQTLKPGSLELEAIRDMSPDVHDAVLTKDLEQVVAALKKHHRLEIDKQRDRQAKLFRAYLNPLTPESQQVIHEEISRNRIDENLAHAHRYLPESFARVFMLFVSTQINQVTVKALVDTGAQETVMSLECAQRCNLLSLVDRRYHGVAVGVSQSRIVGKIHLANLKIGETHIPFSCVLIESLHMDFILGLDLLRRHQCTINLASNSMQICGVTVPFLPEYEIDQRPFAAPAADVPREVGTAINSSSSGVASSGGGSTSLTSTVPASSDRVISREDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZW6</accession>
    <name>A0A061CZW6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0102820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766144.1">
        <property type="nucleotide sequence ID" value="XM_012910690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZW6"/>
    <dbReference type="STRING" id="5866.A0A061CZW6"/>
    <dbReference type="GeneID" id="24562499"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102820"/>
    <dbReference type="OMA" id="CVINIGF"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="595" mass="66039" checksum="A06CA35C26651E2C" modified="2014-09-03" version="1">MLRHVLTLSSAPLNLARGAHNSRSFSSAVNFGAFHAKWWDIDGPMAVLHDYNYVRVPFIAKSYSLLENSNAAGPTPEPKLPSGFLSERLFKHAEERSKIHLETVLGGLRVLDVGCGGGILSESLAKSGAHVVGLDPSRELIQVAEHHREQDFATFSKRFGLRDDRSKNVQYLAWTLDDFASSAEARNFDIVVASEVLEHVPNSSKPSFVEQLSRVARPGGLVVITTPGRTLKSCLVNIVLAERVFQRVAPGTHQYDLFIAPDKLREIARDHDLTEIHRQGLFYLPFSRRFIHLCTCDFLYMIAFRKRPGEPFDPCHDSRIATNPVCPTPISVMLAQEYSDSTTPPEPPRCAVCSSQLTFLIQLGTPYRDTHVRTLYVYFCPAHSEQSEGWRVFRYTVAKQVVQVQKQSAFDEMNSLSSWVDDLQLFPTGPVGGKQKSASRAARSADDDNEAYRVLVEEDFLTPLSFPVGGPEASRLFEAYKQRDPADVDEEDHMDLDAIRQTTSAVDSQDPDSEASSDESDEVQADPMLLEFQYYVTMRPHAVGGRRGQRAHDFPRCCATSGTVNRCCCTRASRSTGAATAAGRSAPSSSSCCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZX7</accession>
    <name>A0A061CZX7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0104650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766342.1">
        <property type="nucleotide sequence ID" value="XM_012910888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZX7"/>
    <dbReference type="STRING" id="5866.A0A061CZX7"/>
    <dbReference type="GeneID" id="24562697"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104650"/>
    <dbReference type="OMA" id="YWANGEA"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="485" mass="54295" checksum="EA365A9E77D6418C" modified="2014-09-03" version="1">MCNPVAYWCCGFDSGHRLTLDEQAGCCVGQANDTAKRGTGLATRGINRMYGARNLYKMFNDSFPRPLEDSSSNRKHDEESSWFGSGFVDMVVNNTAQLANMLQWGERDTYYSLSKEEAETTETRNRMCQQTDNANTSSGSGSSEEDAGYTPSSTVVDMTMYDRLGVECTASKSKIKQAYYKLALKYHPDKNPNDEDAKRKFQEIGEAYQILFDDATRQRYDSQGNTGEYDFPTMDASLFFMLLYGSEALVDYIGTLKIAHLLKHVTGNGSRPKNMSNEMEVEQTYREVSLAVKLAKRLDNEVRGGEISQELREDLDKLCSGAFSDALVDSIGWVYENCGDYFVADATTLWGIGTTVVNVQAAGRTLGNTWSMAKSVVNVAMLVKDMKTGQDQHEALDQLTNIVENVLSIVLYDVENTVRSAATKCCKDCDVSVEQRLERARALVTLGRYMQETARRYRIQAPETQDVSKRLLDALEKARVKKNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D046</accession>
    <name>A0A061D046_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0103570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766229.1">
        <property type="nucleotide sequence ID" value="XM_012910775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D046"/>
    <dbReference type="GeneID" id="24562584"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103570"/>
    <dbReference type="OMA" id="PYNGHIN"/>
    <dbReference type="OrthoDB" id="361225at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00970">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595302" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="180"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="457"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="596" mass="67099" checksum="67FBA41ED104461E" modified="2014-09-03" version="1">MMWFSVLVGAALACVCAVENAFARTPHGRPPAPPLIFTGKSGSIKYEVTLDRVTLGQPHEANIVCGNDDGTPLGGEFTLYPSDPMTKTLLPLEGDDLEEAISKEVLLRNISRSTMLQIETSKHRGTGSFVKVKYPINALIMAKDPHNFSINYACKYQPHDKSQPPYYKWLEIKFKYVYPMAYGCESGNDMLFKNSVPYNGHINDVRISLCRLKPEPGMIFGIYCKPHEQVVPPNCFTDDQIAELDNAITPLLLPNLEVSDNPKYTVPARLKLFRISENGLNKDLKMTCQCKGFGGISAHLSLSYVVDEVVDSVSYMGDKSLDPKFKIHFQMHTMEPNHTYKILVPPEGWFKVGELGSVGTRLAPKHPDINTFNASPMGPNHATKLTDVVGSKGFQLTKKKNGKLREFTMNFPKDAPLVLKKEMPFIYYDWVLKRKSGRRPVDKNLRILYNIIPTDPFTYGCGVDSRDMFRKKGFELHQGKHEYETVCKINPYVLSPVGFYCPKHYTLEPAGCFGEMLHTESGRVVNLADYAPHANPINSANIRVLDFHVPKSMRRRVKYSNDELSCRCLDPDGRVHASITLDLRQPMTDENPPAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1C9</accession>
    <name>A0A061D1C9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766103.1">
        <property type="nucleotide sequence ID" value="XM_012910649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1C9"/>
    <dbReference type="STRING" id="5866.A0A061D1C9"/>
    <dbReference type="GeneID" id="24562458"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102460"/>
    <dbReference type="OMA" id="WRAVMKG"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="168" mass="19048" checksum="865F4189F5B8F233" modified="2014-09-03" version="1">MALARSRLLKELKESSRMDDPNMRLMLVGSNVHHWYAYIKGPCKSPYEVRDAYLVISNTVQKGIFKLNILCPPNYPINPPVVSFVTKCFHPNINFETGELCMDVLKSNWSPAWTLQYLCRGVSYILDDPNADSPLNCDAGNLIRSGDIVGFRSMAEMYTLEHALKSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1K8</accession>
    <name>A0A061D1K8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0109790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766867.1">
        <property type="nucleotide sequence ID" value="XM_012911413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1K8"/>
    <dbReference type="STRING" id="5866.A0A061D1K8"/>
    <dbReference type="GeneID" id="24563222"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109790"/>
    <dbReference type="OMA" id="ICQQRFY"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="186"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="959" mass="107588" checksum="E970C6E020348FD5" modified="2014-09-03" version="1">MALPAPARYGYVIREYSGWYQVSFKGDDGCRYAHAPESTSLWIERPSAAVTESADPLTDESPVSECSADAILGIININGSLYLNTVVRSEPVANVSFDQATAVDCRSSPIFSVKTVHMFPIDVPRDNGGMPIGRYDDPVLLGDDTVDWQKAQFDNSKNGNPASRDPGCVYPVIDINAGIIGDLNRLLTTGHYYSRAADLTHSLQRQWERDMLPLRPRRFPAEFSGRLASSPNGLYDGFPDADEQSKTLYELADPMFNWSQGMAHNIPPHWLTVLMQGYVGYCQQSWHGKRVEVLLIGRRSVYRAGTRLNARGIDSEGHVGNFVESETRLRVDGGPWKSFVQCRGSVPVFWGQRNIFTPAYFTRPINESEQAFLLHHKDLRDLYGDNVFIWILSLLDVKASEIFLVQALEHLMQTFSSMPIQLIKYNYNEKVKKSAVVPELLAFVNTKLMGKLRSMGYFDGSIMSVKDDVAVSKGVVEHTQRGVFRVNCLDCLDRTNAMQLMVAWVWLADMLDPHGLTNMYEYTEDGDNDFSGSLRQFRDMWCSHGDAISLIHAGTESIYSQHIREGRQSYGAFFHYTKTMVTRACSIVFSDEARQACLNLILNNAGGSKDSPRAVDTEITVPEPQPSQPASLGNLVIWCGTWNMNGAALSNQDNIHDWMASGAENGAEVFVFFLQEFVELSVLNVLSGRTEENKEMLFNGKILRALGELYRGRGVKFVHLKSCSMVGLYMTVFVSYRLAPSVKNIETTAVKTGFSGSVGNKGAVGMRFSIGGHQVTLVDVHINSGKLPTRVRIQELDGVMRNVFHEHAPRVLFDSDLFIFAGDFNFQVVVDDRYTTADIFRHIYGGGLDQLLRYDEFVSDVKNQLPFVSRLQEAPINFDPTYKFKKGTDFYDAKRTPAWCDRILYGGAGLPTRDQRVHCLLYRRHNLMISSDHKAVSALFVLEAQKAPEPEEDSPLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1L4</accession>
    <name>A0A061D1L4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INOSITOL 5-PHOSPHATASE, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766872.1">
        <property type="nucleotide sequence ID" value="XM_012911418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1L4"/>
    <dbReference type="STRING" id="5866.A0A061D1L4"/>
    <dbReference type="GeneID" id="24563227"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109840"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="341"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="687" mass="75000" checksum="66B72D66BA57FE05" modified="2014-09-03" version="1">MVSGEGKNDGDGYDSPVQAYTPVSVKDRIAEYSKRTKGRASPIVPDRRARGFSSASAGGIQPPKTDGGDVALVAPAEASPKSQNRTQSTARKLKAPDKDDYRDLSARPARIFVGTWNCVYQEPEESVILKPQQKDSSWSDRLIHTAESVSQWLGHVFFRPGRDHGDGATDAGGSDTHDTRNQPDPHPSDVKSTIADVNDSRSSSPEKVTSSWLKGCAKAASPGAVTTVSDGDTPEICSAVDSPEVSVEPSMEKPNGVRDGATGVSAGCEASSSGVPQTLRQAPTVTFGNHHEASTSDCSTAPSPCSRATGKSSKVENVSPRPALARLSRNSKLGKTPTDCPAIPVLLRQSTFQLKPLTVDDEEPLRDWIPAGYDVYIIALQETLSCSMFVSITKYLQRQSKEELVRVPLDEYKLSGYGDGAFLHTKSTSIAVWVRKSLLDSGMAKVDASKAIPLSRINRSKGVVSFRMSLCGQVICVVGCHLPTSYSAREKAATYIVRKLCDLYGGPGSNIDEVFHHVLWTGDFNFRVRNVSAEEALALLNANRLQELLFHDELYGGSASLFSAMKFEEGVVRFYPTYKKRDDRDVADYSREGWADAEYHTRFETQWYKGGNVKERVPSWTDRVLKWSLPPLRTCLQIDEATYSAAQPKVKNLLMTSDHSPVGCGLVLWNLRSSAHLLPRKNLGSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Q2</accession>
    <name>A0A061D1Q2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766764.1">
        <property type="nucleotide sequence ID" value="XM_012911310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Q2"/>
    <dbReference type="GeneID" id="24563119"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108760"/>
    <dbReference type="OMA" id="MEHEPDD"/>
    <dbReference type="OrthoDB" id="366165at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35116" checksum="A22154D2B300C2AB" modified="2014-09-03" version="1">MSKREVANNQEPQSGEAAADSHATPQKIDAPASGKQERKSDVKAVQRGEDRSNAKGDSKQETAASNASHGGNGASSNYGGRGSGNNKMSFARMDSYASVAKGATNMQEGQNYRGYYRNDQHRRRADYDAEDEDIVKAMMKLHRNRFREFRKLNDNQYREREAPNSQVAEEERAPRTEETQNSQEPLSTYSSTDSVAVQPTQQNRRQGAGESDEQPAGNSAELKNSRSSDGMSADAAEQNEAAGDETNAFAARPRRHDGVRNNYVDRRRKNFNDRFPADGEERAFGTYNRYKNKYNNHNNAKRDFKKEEKPQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D282</accession>
    <name>A0A061D282_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell cycle regulator protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0105260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766403.1">
        <property type="nucleotide sequence ID" value="XM_012910949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D282"/>
    <dbReference type="STRING" id="5866.A0A061D282"/>
    <dbReference type="GeneID" id="24562758"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105260"/>
    <dbReference type="OMA" id="GVENIHY"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="182" mass="20338" checksum="31A87FF0F9C0FD4F" modified="2014-09-03" version="1">MARKFSTEDIVSQNFIKSSVQRSIKLAIVSQFPSFKGTIDAVLPKRGHIILAKCQEHLTLLLVGGDIVFFQKRDGPWIPSMRLVHKYPEMMPRMQVDKGALKFILRGSNVMCPGLTSEGGAMDDVERGEVVIVVDGRPHACAVGITTMSTKEIREKNKDICIENMHYLNDGIWKFGTTSQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2D0</accession>
    <name>A0A061D2D0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit Tim17, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0105610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766438.1">
        <property type="nucleotide sequence ID" value="XM_012910984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2D0"/>
    <dbReference type="STRING" id="5866.A0A061D2D0"/>
    <dbReference type="GeneID" id="24562793"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105610"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="179" mass="19565" checksum="067F22A8A2C42A40" modified="2014-09-03" version="1">MSSMEGRDVSREPCPDRIVEDMGGAFGMGCVGGFLWHFVKGARNSPRGVIFHNAFYSARVRSPVLGGNFAVWGGTFSTYDCTFQYMRGKEDHWNAIASGFATGGTLALRGGMGHAARNAVIGGLLLSIIEVVSVAVNRRMTPTPRQQFERQMEYEQQNKYVAFACITIVCRNASVPATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2G0</accession>
    <name>A0A061D2G0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767142.1">
        <property type="nucleotide sequence ID" value="XM_012911688.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D2G0"/>
    <dbReference type="GeneID" id="24563497"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201130"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1790" mass="199692" checksum="3D95AA00797BF8C9" modified="2014-09-03" version="1">MAVKGTPVVAAHGVPLKTLKDCLQFLEWLKNRTDVQSSVANRLKRLLEKMYTKVDQRQIESALAQFLNHISTFYHKLCNGAEKIINKPRTAKNALNALFECIPKVLSVMYFFRYHVDEGFKALGGGGWADKGVGVVASYANLGLQLSTYMKFATDIDKYLIEKNYTATYGVIPGGFASDELKPDYQGKYPQGKYMLTDVKNILEKETNKNNLFRDVFSTSVLSKNSGTNTANIANALRLVEDFCRIFERVTKDVEFKNHLQSNRMCINWEELEKHCGKLKGSLGKIFTRGRFSFTGYAREYENLNKENTAKKMATWLKKHLPEMKNNLAQIQFFSSIKHKLNMKRLKSSGLTPSQAPMVATYFTKNFIHYGFTFYFNKYNAKTAPYDILEKDWDSAISELKKPNGDLDQLKTILDGNMCSKKKEREDRGEEGEKEEDEDEEDDEPPDEILEDVESEDLPSPTKTEATKTEAAKPVVTKADSPDDPDKKNEGAQNQGKKAEGAQNQGKKVEGGPNQDYAQSDGNVPSAASPSPDAPGPSSGQDLGDQAATSGAGQQSGQEAQPSRSTNAPNAGTDVDRGGGEGITSNHSVTTSRKDSPRTCPNGKPAIYDRDGKKSFCFPEYKTPVPPKVLRGKSMADIKAMADADTEKRKLEDEEEHQRQQERIKTVHPVVQSSEYYYNNRDPYYNIPPPISSDSHTRSDRERPTLDGVPQEETSQLLNAVVRSRQKDWDQYYLQQQERKMALQKKLYNAYDDHLQDSAIKLAAAESAKQQQLEQKYKNEIHRRVQNISRIPVPPKPPLSITLEPDIVSTLSPMAYITGAETRYISDKHRVSPVAIPNAAAQYGNPVINTPVAVTLDDKIMAESTGVTGNTIKNELHKIKTAHVPDAVSGQVLPNDFEDSSRKREETGIVNTYFQQGTILHGSAIKPHTSKPQTFASWRSPKNSSNPPVSLKKSQGLSKASEVYGMVLEPNQQGKTNVPLHKFKKPHKTLQVQELDGNPYSILMDVDGVDLTKPSTKKVKIVAPQAIPPPVPPVLASGVVVPNTKQHSPSTALISSKPSGLSSTRMDSIDTVQPDEYPVTLFSDISSSVMNNEPNHIKIVQVPDAMNAPMSLPAEPIGYSISDPRDAREAEKQKLQYQYADHDLKNYHDQRAQILADEKDRHAKYLELVIKDDDKEKENRKLLQDVDEKLVVPQSKSDGIDVAAVTLDTLQAGHMGLPIIDSGPAMKLRQDGYVSTTPRAIQPDDYLKEKMALEAETKNVVNGGIQISVKQPYVTELHDNPNHFDIQIDVAQRPFQDLVHNIDLDDPYANTADILKDELKPAGDKGFSGMPNTNFDLDFAPKRIGLEGYEDPGMPRDSPRKADERVINPFSTDECQNPWSVDTSSTDTPPPPASALPPTDHLPPPKTVREMLHWFVGLSQYGLIGVVTEHVKGFLKGYNTDAFEVTGDSDQLTASHVAAKLTEACLYSATVIYKVRHNNDFKAFSTFDFKSEYSKFCYSPDPAGLLCQLRDYVYACHHQLEFLKAQSSRDKLSGGWENYEYGSDITASKSPLQAFLTDDWGSTFETHPFDPCNLCLKSRVRMGFKKTDLPISQQNGNTLSTILTPSCGGEDPLLTLCSYLNCFTRRTPRTIGELVSYFHHFGIELHNYDQKALSSLGTALSTPHAYCPDWDCLGASDFQAARRIRGSESLNATHDHLKSLPKQFGDNLGHLHRHPQLLPTTYHSHALYLLVFEYTIFHFLNVLPCSQLFRLPRRPTSSTSRQYSFTGRGYSYLATTSTASMTPWANIVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2N6</accession>
    <name>A0A061D2N6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0200200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767049.1">
        <property type="nucleotide sequence ID" value="XM_012911595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2N6"/>
    <dbReference type="STRING" id="5866.A0A061D2N6"/>
    <dbReference type="GeneID" id="24563404"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200200"/>
    <dbReference type="OMA" id="CTKDQWL"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="549" mass="61197" checksum="5CC6C29492B0E090" modified="2014-09-03" version="1">MSPRYRLIYMFSQASSGCRGALRFAARRCSSTTRCNVCANRRRLVEHELLDRSSALWTFLLDSAATDLPPNDCSSMSFVVGSRVCSLWRCVGSSRAVRLPAGVSSSTVWLHVRRLSTTKGELPIESAPVDSTASTRELDRKPAGGESELTLPRDGTPLRCTEDQWLYKPTSSEVDLFRNSTLLPPRPIDVEGSVIVRLVDLHSGVTSPVGQSVLYSEYGIRRGELLRFMLFGSFLISVFCSLGYWQLRRRAWKVDILNRRREALSQPLVKVESFAQLEKALGASDDPNSLIEYRCVECTGVLDTSCSMLVGPRPSLYESYGASSGYCVVQPLRFRDGSCVLVNLGWMDSESALSGAGCPELVTLRGILVGGEINDSLVASAKQRIIDTYQCVLSRLFGWSFPPASSSVNRPRRLSRDDSRNVYRYLDPSNMSSDVYSSSLDTTSRYALNAYDVLYHDDVTELPVDGSTPGHETAATEESAYVPKTRIGRDLRSTRPVYQRRQKSDYLLFYADPDTHTNYAYQWFLMAGSIAGMCGYKVLRVRRTLRGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D315</accession>
    <name>A0A061D315_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine threonine phosphatase 2C containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767194.1">
        <property type="nucleotide sequence ID" value="XM_012911740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D315"/>
    <dbReference type="STRING" id="5866.A0A061D315"/>
    <dbReference type="GeneID" id="24563549"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201650"/>
    <dbReference type="OMA" id="KPNMPLE"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="341" mass="37787" checksum="23479497BF51932F" modified="2014-09-03" version="1">MQPLLPTEYDGKEPTPFVALTQPISHSKYDGFSVSAHTAIGMIPRGVPVTRHTGDRKAQEDRFIVVPNLGTNGNQVAFFGVFDGTVGHFASDTIQKIIVRHLVSTDVWAALMRQLDVGEDDKTTIPALAVLAVSKMYSNADAELLELCRKQDNHYSSCTSVTVLLVNDYTIVAHVGDSRVSLCYEEGGQVLARFVTTDHKPNMPVERRRIQDSGGSVQYLSSHHNKPFLRGGDFLARKAKGDQPMQIQYSRAFGGKDLKTFGLSCEPDIAVFRREGQHKGLILASDGLWDANECQKVFSTVFYALRKGENPSRLLIDNTLKQLRCTSRRSDNITAIVVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3B2</accession>
    <name>A0A061D3B2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication factor C3 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767274.1">
        <property type="nucleotide sequence ID" value="XM_012911820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3B2"/>
    <dbReference type="STRING" id="5866.A0A061D3B2"/>
    <dbReference type="GeneID" id="24563629"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202450"/>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="348" mass="38677" checksum="151610FF1D884854" modified="2014-09-03" version="1">MSVALGAPWVEKYRPESFDDIISHEDIISTLMIFTEKGQLPHLLFHGPPGTGKTSTILAVSRFLYGSHRNSYVMELNASDERGIETVREQIKTFSETSNSFSSGVVGSESGPRTNLKLIILDEADQMTNAAQNSLRRIMEIYSSNVRFCLICNFMNKIIAPIQSRCTGFRFPPLKAEVVKRRTAEIAKLEGLNVSDCALDTLAEVGQGDMRRVLNCLQVTAMSLGSTPDKVIDSDAVLATAGLPKLSEVNVLLQRLMQDPFKACVEHVTSLHQAQGYSVEDIVMALYRAILRIDWPNVVVVQLLIRLADIEQRMSAGASPYIQIASLVSAFTEARFEIERLKFDLNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3M7</accession>
    <name>A0A061D3M7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767374.1">
        <property type="nucleotide sequence ID" value="XM_012911920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3M7"/>
    <dbReference type="GeneID" id="24563729"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203450"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7235" checksum="EFEFFEBA84FAFCFB" modified="2014-09-03" version="1">MCHPRFDFCRSGSSSSQVGSDGCCAVRASSALLGAVGASSCTFETMIATFILRAVLRIFVHNDGMNSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3S7</accession>
    <name>A0A061D3S7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0205190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767547.1">
        <property type="nucleotide sequence ID" value="XM_012912093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3S7"/>
    <dbReference type="STRING" id="5866.A0A061D3S7"/>
    <dbReference type="GeneID" id="24563902"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205190"/>
    <dbReference type="OMA" id="YKYSVYC"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="432" mass="47484" checksum="00C32993368369EF" modified="2014-09-03" version="1">MDTLTPFTATYRLRRLLTSCSGGTRCGCVLQGRVGSPSSGVPETSRDSEILVTGGNEGHIGIWILSDDGNVDLVNEFIGHDGIVMDLIGSCVVDSRIESEDSPHEGAGKTVSGISLSFYTCGRDRMIHRFDLSGRKLMTFKGHEDVVCSMQEFSNGRDLVSGSWDGTAIVWDALTGAIKYRLGGNPYKYSVYCNTKSDGTILTGMTNGDVCCWENGRLGKAQRVHDGVVRAISVKDNTILTCSNDCSVRKYSDDMDLIYTIPAAHQNFVYDVRHSNNFPIFFTSSEDKQVGIWDLSNGILLHLLSFESSIWKVGYCLQPTHLQVVETQRQGIIIIPLNGSISLWQLAQDSTTVLNAPQVKVVEGPTLNVARKAIVTGGSFEMIMFRQANGVKALERLTVFNRSKSSAVGLHGNPEHCYCRFVFQKAILRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D489</accession>
    <name>A0A061D489_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNARE domain conatining PROTEINS,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767742.1">
        <property type="nucleotide sequence ID" value="XM_012912288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D489"/>
    <dbReference type="STRING" id="5866.A0A061D489"/>
    <dbReference type="GeneID" id="24564097"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207140"/>
    <dbReference type="OMA" id="LGHYFFH"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="205" mass="22453" checksum="0A3F5BEF6FF83AFA" modified="2014-09-03" version="1">MTAILYALIAHGGSVIADYTVPQSHVSGSPQFHVNLDAVARTQLSKLLSKNGHGTACVLGHYFHHSIIDGLTLLCATASNEDDDLPRRFLVLNNTSTRSELLARILSRLVNDYNATTDKLRSIESNLQQTTDTLRSNITSILERGEIIDSLVSKSTALKDETLAFRKVAQQANWGFVRRLLHQVSDIVLTRNFAATLSVGVLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4A7</accession>
    <name>A0A061D4A7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Asparagine rich protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0200390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767068.1">
        <property type="nucleotide sequence ID" value="XM_012911614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4A7"/>
    <dbReference type="STRING" id="5866.A0A061D4A7"/>
    <dbReference type="GeneID" id="24563423"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200390"/>
    <dbReference type="OMA" id="PRGCIFL"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="723"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="830"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1151" mass="128519" checksum="AB9E88D956A637CB" modified="2014-09-03" version="1">MWFQLLKNGNSDKERLQGCSRRFDSNELEVLHKLYKELASRSQTSGIDKETFLQYFDLPGLWGERLFRHFDTNDSGDVELAEFLSGVAACCRGTHTEKITVLFRMFDLNEDGRVQKSELLAMLSNFPVMTSNMTKCSQRQLSNQSTVIPSSLPSAPRSGGTTKRSVGVEKLNSYVSNISESKCIVPGFHEPMIVKRTEPGPTAWKDVASSLSRLSLQSRGSIEFQSSMDISARELPDSPRPNDALAKELLGKKKVNGTTQSRPESGRSQNSGLVDRLSSVVALRDGKPDVDPSYGSSTRESGQSSPSIHRGDGGAAPEQSDPCPAGEDDKLVNKTVSDLKSTGKDVCRGTTERDEADVSIQSQSIRMTDLQDTDESILAANAIIEQERLSCGDSTTLDILVEDILEECQFSANGSFDFPAFKAWLCKNSSVLSMFSEYLHEEVWGLRGNAFMTSRENHALARGDVNMSRYPSVQYEQTDNDLSGRTDPELPDRVVQRMVYQMFLTNGKQSRAFEDSMSSLGNVVSDELLQYVQHVSTGTPTAADVKPTTAGHNPADQKAGANRSSPPMAVSIGRQLLSCPKCKTPLFMCPVCFRRHDELTLHISNEVHVECKNCSKQGQITVFTCCWICNWDFTAAVTLALSELQKRATNVDRKEGLTSPVVKAASAPCTGILREKRRSLLRPTISVSCSSSTSDSQSEINSIDDPGEAHRSTAEWPQPVVKMPQKVGYMYKRGRHFYTWEKRYYMLIDNVLYYYVSEDSTTPRGCIFLEGCYLDSLADSDVSNMFGFCICHKGQKTTRRKLYAQTQEDFVQWVDALSAAMKQQSLMQMYTVCEQLGHGKFSVVYRAINNSSGEEFAVKIVDKTRISQQERELLRSEIAILRLLRHQHVIYLKDVSDMRDSLYIVMELVRGGELYDLITQRHRLSEAHTHKIICQLLQIVAYLHKCGIIHRDIKPENILLTDKSEAATIKLTDFGLSTLCGPNELLTQPCGTLAYVAPEVLTLQGYNQKADVWSVGVIMYLLLRGRLPFSIKQPLTLDLIGHYRVRFDGRQWDSVSTCAKDLISKMLQPNPAARISVFEALEHIWVSNFVAVNHDEVYTGVGEIETTKELMRSLRYATDTTLVIPYSDSCANNIDALEAEEAEGGLTTVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4N3</accession>
    <name>A0A061D4N3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766090.1">
        <property type="nucleotide sequence ID" value="XM_012910636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4N3"/>
    <dbReference type="STRING" id="5866.A0A061D4N3"/>
    <dbReference type="GeneID" id="24562445"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102330"/>
    <dbReference type="OMA" id="NDAMQHN"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000205">
        <property type="entry name" value="2'-5'-oligoadenylate synthase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="121" mass="13634" checksum="1869E00C7A8947FD" modified="2014-09-03" version="1">MAQVAKGDVSMMIPLRGGMRVQVQTMQGKRRSRKPSQINVGQKLEVDVEPNETVLDLKKKLSSKQKLPVDQQRIIFEGKMLQDNKTLAEYNIKVGVAREANDAMQHNSVIHMVLRLRGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D505</accession>
    <name>A0A061D505_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">URB1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766230.1">
        <property type="nucleotide sequence ID" value="XM_012910776.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D505"/>
    <dbReference type="GeneID" id="24562585"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103580"/>
    <dbReference type="OMA" id="ICTIRLF"/>
    <dbReference type="OrthoDB" id="362025at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 C-terminal" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1649"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1849" mass="206999" checksum="5154B74008B73B58" modified="2014-09-03" version="1">MENEYCVTGLQVAAAIVRRDFQAICPSYTLADSDQQPKKKANTGQAKHEQVLYRPFNDDAAAVNRYLAASPRAVEVFDLLTSDEPEAQKPGLALLWFMLKRCPAAELKQQLADHVLTRLCERIPQLIALGDTALHYLLSTVLECLLAAPEESVRVFLTAFTFHKFLGKHAVRKGACSAFSVSRFYAGLVDSGVVEDVGLRDFLPTTSGDTCDVADVVELRHANSKKQLCILLMLGLKGFNIIRRSTVLHQIFEHVKQDGLLDSICTIRLFILVMANVISTQCATLSITLCNAQRSDLPENVIAAVAGALSNAIGQITTMPNVQHEWMIRLNGTVAATFRDFVTNVKDMCDVATLAKVLLKFDAMQLTIVEILLPFLKANAQLGRHYMPALRCRFNGVLEHIVLVKFATQWFKHISRLQINQGEALEYLPSFLNHSFFNAGLLSNNRWARLGTLRMLVALMRFVTSSAGNESCCDIHPDVREKMCNTIPDFKTLLNVKPAPKDQTAADGPSVSLNIKNETRIMLSNELKSVVTEESGDIILEIDDDDGLTEWLQCLHLYGIFVGIREGRSLYDPCKLLKEKVIIDNASEFAAVINNTDDETICTKKLRSVLRLDMALVDCLFSIGVGEIHKGVALNKVQSMCFNFVLRRYTELKAAMQRNSWDEPLIKSYMHKCEHYVNQVLKGSGVFPSDPSPWMGAIQSQEDYHIFLKIFNHCVQMPLDALLGSLTQKEAENPPTKYTCVNCITSLEFDGPLILRLSLEYLLHLCIDSKDALQCESCGNRRVNMVVALRNTGEEGNIDPLQYAKYILRACGNPSSGALKGHAKRVIQALLAKHDIVKEAYGTMKPQKAAVMVDAPSKIAFDAEMPSNDKQVPVQDTYLRACLVVIDAVDKFCTDTVFMQQCGRIIIEVLSTRQSELNGVSVIKQKWCKDRYAHFVDRCLQMDSFNLYTHLFSILVDLLGDDNRLEVAPSTFEGIEFNDDIRWMQLLYLKCRCTLEPEHITSSVDFKERFTSILRRICSGYRENATHKTAAALAISKLSKVVPPSLLEYQAAEVLKDVMEQLIMPENRCMCKDMLQCEFAFIKYIMDIASRLAETLPASEAETAIALLQSKPMLKLTDAVCELNRPNYFIGDTIESNLLTSHVTMLRSLVRFVGPRYTSNVTFDRAAVCRILEALKGCYRCSYDESDLALKDVIMTLVTVASRMVGDEKSMPLRLPAFQDFTCVNGLSSMNCESASDTNKLMNVEGSGTTSGDRGNLSHGVSRGWLTMISGFACISNASNWVCMNAKRVAMTLLKFPYKRGSETTNLKTTFRNLAILFPPAVRKANNRSDHIFGAITLINKILGSNSMYMQQLIVGDPYIYDVEYLVPFLTGRLCGMLCDQLYQYKLEFEDTFRQMEIRGIQLDHNYAPNRFAKWFSLSETTEAAGRIYAQIQHMQFNVALGESFSPVLMEQVVRNGVVELCILGLVSDKTRKYALKALGIVNKIIQNMIDAAIVRSALPGSSGPFKIRRVGLFGVYQLHSLICFIQRCQLYAKSGNDALHVLLASQVVRRVTKPEDPLYQLVNKYLLLRFEVKMDDVPLFFECFTVHNASDRLNCLSFILQLLLSSGHLLNDYGIMFRRRVFQQIMSFSLVETTTYEQRVQIYAFMQLFIKRNPGTVDELHSIGTATWIATASHVIWDAAFIDEKDLVFSTLMLSPLTLMARDLALATCRQHVDGSDGNGEIKINPQFKSPMVCDIESDDKSVHKRQIGITIESNIGDAVATFEALQRVAEAWYKIITHVPREKIANVTSDGYRIYLYALEEGLKNLSGTFLPPNAGAGGTTSSMIWTAVNTATLAVGRLNNVIADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D524</accession>
    <name>A0A061D524_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1, regulatory (Inhibitor) subunit 7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767333.1">
        <property type="nucleotide sequence ID" value="XM_012911879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D524"/>
    <dbReference type="STRING" id="5866.A0A061D524"/>
    <dbReference type="GeneID" id="24563688"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203040"/>
    <dbReference type="OMA" id="NRIEEWN"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF37">
        <property type="entry name" value="OUTER ARM DYNEIN LIGHT CHAIN 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="35221" checksum="1C1481DA17C09D23" modified="2014-09-03" version="1">MATDAGIRVQRIGIDLDAPEGSDELEFHCARIRRIENLADLTGLKAMSSLVEKIENLEANRELEVLDLYQNSIAAIENIDHLVNLRVLDLSFNRIERIANVNSLTNLRELYLTSNRIAKVENIGSLADLELLELGSNCIREYDEIRLLPRLKALWLGRNKITHMRLPPLPNLTTCSLQNNRICEWAPEIASSCPELQELYLSFNRLSEIPPLVNRMRKLTILDLGNNHIARINIEEPNDCVVELWLNDNAIEDERDIEPLKLFRCLKVLYLERNPIQAKLGPGYRNRILHILPQLMQLDALAAGNRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D577</accession>
    <name>A0A061D577_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acidic leucine-rich nuclear phosphoprotein 32-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0208720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767904.1">
        <property type="nucleotide sequence ID" value="XM_012912450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D577"/>
    <dbReference type="STRING" id="5866.A0A061D577"/>
    <dbReference type="GeneID" id="24564259"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208720"/>
    <dbReference type="OMA" id="VTNENAY"/>
    <dbReference type="OrthoDB" id="2160613at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="30386" checksum="5214882EA404E818" modified="2014-09-03" version="1">MDVAINNRLKALREELNLEEGDESVYTHLRELILDGTVIKTLTPQDGDLLAKFKNLAKLSLNGTGLTSLTNFPEMRSLKVLEMTDNYLTDTVIFSMIPNLFPNLSMLHLGGNHLKTIEDVHMLRPMKHLVALGLAMNPLASAENYREAIFSALPNLQSLDQVDHSGAERHVDSDAEYYDEDEEDDEEEGDDVLKKFYEADYNSDDDQNDEEFVPDDGQEEEEDFYEDEEEEEADDDDYAENGDGTSSSSSKRLREESDDEADHKKVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D599</accession>
    <name>A0A061D599_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MATH and LRR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0210140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768047.1">
        <property type="nucleotide sequence ID" value="XM_012912593.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D599"/>
    <dbReference type="GeneID" id="24564402"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210140"/>
    <dbReference type="OMA" id="AHWSFSS"/>
    <dbReference type="OrthoDB" id="428753at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="76"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="1250"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2156"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2782"/>
            <end position="2801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2168"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2181"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2249"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2783"/>
            <end position="2793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2801" mass="311913" checksum="8E301D720DD798B1" modified="2014-09-03" version="1">MEQVQKVVLPGEREAAQNNGRFPAAERRPDDYSPEPSPQDGGDTDLYYHDDPQCPCYVCTNGVMETKSTLANDDTSTGVEFAVRSFWRIAKTQNDVESPMEGHCRGFHYKLLLHPRGTAGTDSEASHLSVFVEASVQDWYPQYWVFPNVRFELTVVNFKDPKQSVTSWAHWSFSSDATSRGWQKMISHTRLTRASGFMDEDGTVLVRGKAEPPYPMLWSNSPLYHPQMMWEYIPNRAQREISAEAHEEKHASGKCKRSASLPDPVPCHPTCTYESHAPMCKNAAIDLPHGDPPYAISDKEREKELRAFADAQNVHRIYAKAQQKVGEPAMQPADIQGQTPPAPPLQPDQGEFSADGPANDESDGYTEINADDTLMHLQPDEYPGVSNHTILRFLDSVIPAVQPTLDADLLALMTHILYHIREFRKRVLMWNPPEGIDDGSSGGNGIIVALQKTFAYMELYPLAAACKTYKLAGIENQQLSKYYLYELLPKLPNVKKGYGLLDYSDTAALGSLSGLDKSTSSSFESNLQQGAYGGRGRSPKTGPWNRVHIPTPFPQPSDAKGYNAGDGDFRHPKCCYFDGGRYEWELKHRLPREDEDAEEAPAEVQREQREDPDTRPSKIFGTSDVYKPNFKLLPGTLSFSIGNRGDVFDKILPPPPNIKLLLKAMHMSDLQVLETQDQLINIHTELFSMILRDLAAAKRAIKQKRLTEQKLAPTSPNSGLHPGAPAPPAWEFADKTDLEMTCKTLFSGTSYRYGLFHHNDVNEIANVYIRCKHSHSLQKALENTTKTMTKYPEVLFFYLYPAKNAKKGELFDIPLRLDCTNLRDGSAFRNGTVDVSAAAAGQKGSGHGDNTCDSGGSAGAVDYGGYSDEEDEEEEEEEDDEEQDDLGSDGFGNFDGDGKKSRHPAHIKWYSLYALILREGDIRSDGTGNNGGNFHSLLLRPEEDGPWYRIGEGRVEKLSTKMEFTEWKCHRDFFCAAAIYVAEDYIDMLQVGEIDLSGNIKTWNPKLYYETLQQLGVTEQDIANPALALMAQKHAEPPIARPYYNEEELMTPRGSASPTYMSPRSPSNDAVTARGSISEPADTASEDVDLVPVAEPAPVQKDEFVDVKTLLEDDTEALDISNVDIIYNRKVGQRHPKLGPCCEAHGYSSSALNDMNAKEYATKVLQPSSAKEVCRRINRAETIRPFIRWLFHASKENTTVLNGIKLPADGKMLVKFLQQRERYFEEEFCHLICEVLLKEIGEHMALNAVYRWETDKSWCGCGCRRCEKTCPAMLLTENGRFPGEELKAMLTEPSTILFRNIQILRCHLEYFCKDCRNLSMQLKDEQRVADIREFKATSERSALFLIECIWDACVRYTHDCRTILYLKAISDNPSATMAELGLNKMSSLVKPSAIPAAKQAGSLNQAVDQCRDLFVFDGTLSQNADLLEGELLDYYDTKYDLTIAEELRIMRYFAAKYQLPTVAQMRKFLRENHILVFCYIRPHELLRAYLEVKNPGIRVKEEMEAMLPSIIWNDAAFEQRVSISSLTDEEKAGYGIDVANVNIGNGVGHSLCDIYEQLITKMLLHMQDAERGLGSQVLDYIYTCGDVAKVVGAIELECRRTIANSNLVVRSKSLEDSCSCNGIAGGCKVSPVLGGSSYFPDFGLSRGPFSLDFVEIAHSEPWPCGLRSECASFTEEVSDITAKPADAKRKQKAKERKKTVDTGACIIPPLDQVLRDVNISQKTAHAADPKLFPELTEVIKYPNGAHCLGSTGALAKLRRWGEYNSLLFHQTLGYDFNVAGGFASMLKVENYGSKATAHPLLESRKYNEAQSLRIKNALELGIVTTHDLSGCEGFASEEKLVPTKRLLVYHEYVSPKTGKKVPVKVEHLYWGLRRLLQQQVPADVDSVFVQASKGKKAKGSAKCICGGRCDSDEYECTLNMRWKALPRDCFVLYALRPDNNNPIRRGRRRFTFMHPDSELSQYVDGTKKQVNPKTPDLVVLIVGAPLSLCSTPSTPFPLTDDTDYPLLLFKWMCSDSVDLICYGAVICDAKKQLQHYIFDWLLPLVRETGMLPKLAPNEKEDIEKYQILEECSVRTVQNVRRWSCAIRKINKRTGDIIIAQVKRLTDSPATLKLRETTAFLHTLREIEELEALEYLPPAVHVDDIVDPGKAKVDSIEPLPKAVEDPQKLGKKKKKKKVTKTAIPSNKKSTFSKSIIPVESDSEGSVAEPSQQEDTAPSAEETLASEPDVEKITDVGVAGKQPDSGAPAKDDDEDEDDEDDDDDDDDEEDDDVEEAESASATVVEEMRDEPYAEEAAEVVDIASLVDDAIAAVASSRTVVDRSALEKRGLPSGRMQDFLQKVDMPNLLSNDSEMVTQMCGYIQKVIEGELALVVPPVSSPSRDQIVITVGSKVRTCIDILLCLIRCMNKNGWLISSFRNIINAVYDQAPLSAAAMACYILSAMGNICIMENMKSKPATEFVRDLVKKMADQCVEHAWSVFGSTDEKWTVTSMLMCLYIYSAANENIAKICDQNPSLIFLMHVVREKLAGVQEADEEERSAPVTFRMDALERFLGGPGYAAAVTASLADQVQKAPGLMAAFKNAQPPFSNDELLMAFERITLQEQKIWWQTREALLANIKALLEHGVVTFVAVMGDAESQRSRHVDNSLPLEISLAEFKCLQQCCSRYPNDLGIATAGGLIHAGPRSAISTGHYHPAGDAASVVDAVAALSQLVKSRSRHRAVANVALDEGDQTSVFASLDDMRLWGNQTTLVIMSVRLSGTLDSVSTADVDAILQHYYARTVRTIPPPPRLPPQQPQMVGNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5G5</accession>
    <name>A0A061D5G5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768147.1">
        <property type="nucleotide sequence ID" value="XM_012912693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5G5"/>
    <dbReference type="GeneID" id="24564502"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211080"/>
    <dbReference type="OMA" id="RYNEPMM"/>
    <dbReference type="OrthoDB" id="360581at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600071" evidence="1">
        <location>
            <begin position="30"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="581" mass="68673" checksum="89915BAE7A85BC2B" modified="2014-09-03" version="1">MPLKTSKIATRLVIAICAVAACCYKPCVGLYVPHSAPKDGILSAVNAWAAPGFLAAAAYGSPPRHAKHRNARLRLTSSRNVHWLPVNDGGGGESYPLVGSGTRNGRNDAQYRNFALYAKPVISDHSYPRSRIPRHATVDYENLLRSHDPEQINYNTRLRDMPGVDMGALDNVYGRIFDRRVLIKQLRYFLERDEFHSIKRLLSENRLVLTKEDCKRFVDDVDHLLQVRLGYQEPTDENMEQTMPFLVARYVLQHLIPQDRQTLSCYRWLEPKEAPADVPEYTEDYEEPKGTPEKPARVEDTVAYRKIMKRLRTVQPELRLKVMKELFLRLYRAKRNKLFECLWKYQRLKPNAEVWRKRKVRNKVNIDRVSPFLSRPTRCTEEMVKEYTGHFEEAVNKGDLATACRLLKRYVRRIDWKNNMRLMLKFKDLFGEMHRCRKYSLEALRKLRILYWSTVKFRKVLIKINEPAMVHEAGKTMKELYEEQLQNWRERTRAKNDELMRRRGIDMDKVRDFSNIYGFDWVPILYPEEYEAGIKAQEERLNKLRRKAQWVKDELQRRRIREMGEGDEPVRKKGKTPTLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5H3</accession>
    <name>A0A061D5H3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0211180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768157.1">
        <property type="nucleotide sequence ID" value="XM_012912703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5H3"/>
    <dbReference type="GeneID" id="24564512"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211180"/>
    <dbReference type="OMA" id="KCHYGRR"/>
    <dbReference type="OrthoDB" id="20534at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF50">
        <property type="entry name" value="RING FINGER PROTEIN UNKEMPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="385" mass="43677" checksum="54CA2E7497BCD3FA" modified="2014-09-03" version="1">MAKACHQQVLAHPSPKADGSAKRQPDAGSQAPKHVCLSGKELEEFRTRQCPMYVKGACSDSIRCSMSHSETWPRRNPSLFKYDYKLCPNIQFLRTENKMQLQGKCHYGRRCKFSHSKEEQLYHPDLYKTRMCLNYPACKGYFCPFAHSKAEMRDRKEGGGSANKDKAPKAAEPEQAAPAAAPARAQLEETQYASTEPKMKEMQSQMISEAWSSLYNAEYKNADYKFLDVNSLNSTVGSPNTVTTQEMSANIDFDINATFEDTLLGHEDVTDLEERNLRFLNAYFARRVRDLDENQAAVSSTITTAPQRKQPANVVCNSRDNQAVEDDDEDGWLEDVLQTGLQLLRQDTYEPLNREPTSSQSPCPVCKRSREVCNHRDRLAQSSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5R4</accession>
    <name>A0A061D5R4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768247.1">
        <property type="nucleotide sequence ID" value="XM_012912793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564602"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212030"/>
    <dbReference type="OMA" id="MARNANC"/>
    <dbReference type="OrthoDB" id="364471at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1354" mass="149181" checksum="90674CDF9852B532" modified="2014-09-03" version="1">MLLSVGAPEVFQLQPYPRDAAVDRSISPSAEPAGFVRQLTARFNAQEASSEAVVGVSASNCNQYLFVLTSRVLHVYNNFEPNIHVGHLALSREWYARYGAFCGLHMVPGLRTLCLLLERRDRVLVCTYEAQLSLEGSNGSDNGRHGSYSSHGTPMNGRSTPMSAPSIQGSPLKAPPRVVVDASLRRKGSLETSSIKHLRAHYDKALTPIRLKPLLVLTLPSAVCDVTFAEGQMYFWTVEQPGMYVTLSPEGFVNYLACRTADDEPMEVSLDLHGTNLVQDMAVNGTVSPSHGLCYLAFGDSLYAKINDTSQGRADLEVLYNTTGSPISSLVHWVTMTCFRQGTGVLPPEFALNRFSADSLLSDLENTVLPGKYTLDELVGDVKFRQVVMARNANCCLIVTESGALIGLHIARVKSDHIGQLVYREGVERVAAVGSNLVIHVNGEIRVASWSDGGIEEHWSYRLQNVRGLAAHNDVIIALYNNDGFICFNVLGAVLAHRRSRTRCATPVSACVTAQGLALIATEEFSFVKYRLYNTGYNEMHCSNPKNNSVAFVGESDILIFHTRALEGTYGIPSKKLAEDRNNHAYDNNDLLGDLDCTLHAVPLTALDTGAGGWPLVHVAPSPNGSQLLCSTPNASLLYDGEWRWFGEDLGPTIATGWINESICFVVVKLTMPFVIANRTFESVDSSGDYIDIGGWGTSYCHFYHVYDLTKSIEVLPIRTSPLSCTVHGETLYVVDDANIIAGYHLRCEEGTYKFDEVIRMRIKGKVQGNIKEVHCLEENHFVLLDDRGGVYRVRNGELTKVIDECSCITSAVHVCGAAEKVVLLCSLRFREQLVMVTADRVSVIEAQITPAALVNEGVVAYLLNALDADDSVQKVRIAKLMLPIDDVDDALLSPFHVELLDMMLTVATAKGAVVEPAFRERFAKLPGDLQRRLLARQSRKHYVKEDIERLESEFGCSIASVFDCMLGSKRVADASFMLLALQSVTDPLTVRNTYNVKLLQMLVQEFCTRKTSDNVSQLFSGLLSFQNHVDGVQGLDVRALVKALLSECNFMAVYKLCQLLIVEPSSLIQSMRADLEDMFVWGICRPQCRDARVVGRQRRQTEDTVPQTADMDQDAAEHDDEARSASDPADPEHTEAGHADVNHVNEDVNIDSSELHSTEHDSDDMQQDDTHTTDAMHDETVYCTKEVPRFAASTQEADQPMDQDGHQPGLPTAADSCCGAVVDVAQMVVALQTQLGLLGETEEARVSDAHIKARNDVLREQRKTPLKVSPYAGTAICSYFYDAFIAQNLFVPAVAIAIACRNFVAVSQVILKDPESSHVVRHVISHHCGCSLCESKFNLIKHCLLEAKQRFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5V7</accession>
    <name>A0A061D5V7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768287.1">
        <property type="nucleotide sequence ID" value="XM_012912833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564642"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300060"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1780" mass="199703" checksum="83DC3C323CA08666" modified="2014-09-03" version="1">MKFDKILNLKITLNNNPTNILNNLCTGLETFLGFNSASKGYDGSGIVYSDLDRLCDGVMGFLFSIITDVKDDKNLTKYNNNIDTMLEKIKLAQYNRKNFDSSIREVSQGIKAWVRGVEERNESITKPLANLEKTLHGHASVEMDDNPITDQLSTWQGFSSIYLQEVEKSEIALDEIDDELRNEIAPKIELIKQVVDNFWNSVNDLGVYDSVKKLKDKFGAIPKIVNMEIGTQIQEVNNTLNDKFEKMFRDIHNLTQNKKSHINSIRKAVQSAKQLADTLVDDSTNVFDKKYKANISDRFNEIKAKIEKFCKVNGDGQPTLFSEFYKVRTKVEGLETDVRHGLGELKQEINGLTKDMNDSNLIVKEALQQLETDREPLYRLTFNGANSIVTLTKGLEGKFQKVIQQDLKSSISEVDNAIRKLGATFGVGVGGDKKLRSILEHLRTQIGTIKGSDYEDKGCSAIVARVKSYAAKFTKSKFGEKVLDGWIGDILKEDSVVKTRIEEYIKDNNGTNNRGMNGVGTNRFTNPLIKADELHNPLKTEIKTVLNSEVIQKATENFNDAQDSVEKNLNGLHGVCTAFATELGKVIDGKDAEIARQVDNQVRDNSKGVTEQSDLKTAVKYILQRLVSRANKFASDIGNLIKECEFSNVDAPSNTAVDLYKKLYDAMNAGVDGKLSEMRSKIRDLDNIFTKGVKNELQTETNNIERVLNNFNSNVKERIKDAAEKAIEQAVGKFGSNGIMNLEQLMGQFHQSERALQSSVKQIENQLNILKTFPSAVDSKRKNAEEIMKTLKTEVREISAKIEAIDPILIKAENVLGTAIQTLERSLEDTRKYTTLVLPLLQQNLQQHVTNSFNEMEEYVQEMFNAQRKAEFQSLKKSVDIQIPQIKSIIQSDMEKGLKGLMKNLKGPFAQLLNSGAHLSSYTKRVKEFFANLLEDLTRQSDVVKYHSPLLTPLSSALSALLSAMHDQRHFSADVSLRLAELQAALTTLTPTAFAEASPLLNVVKRGVRAFHGELAKQYVSRYSGKQITWVKDVGKPPKSEPTEEALKCGKVFFSCLQRLFDGLHELWQNCANKAAWEHKTISLTETAQHGNTITNPLGSFFKRSGYTVCSGPNKHNGELRNTVECRGGHIHQKLDASIRGIDSKTYKLVTKEDEEKEDKDSIQNHGLLKKLFDHLHDYYTVRHLPHFAARKYPCSVFDMLKWLCGLTSSTVYNDLTLNGFDVLFEKDEKETEAVTDFVVVEAKPPSLSAYPYDITSRILSGELAEVCHYSQDVLTCLLGNGHADGIYACEFNTNYDGFMYPGNMDTLLCMLREIVNRVYLQLHFLFQQCQYGTSLSGWLECEYGRDVGGSSWQCNTNQCADQKCKQIADQKRNQNCKLHPKCGVKSPLQSFLEDGLQGFLPHQIKYEKGKLECNVKSHAGIQCITPMGFADISHVASLTQTGHRIADVLAGFCGNQMSPLAKMCSLLNCAILSAPKTLGEMFAFYYGFLDGYYDGNTKRMKHRELPYAEAVKDANFKNDNNRLDITSMFKSSSHESVPASTHTNGDLFSLVGCNPKQNPIFPCGPYLQSLSLSIHCMFSENHADKYLSWIVYLTETFYDLLKKLFEDCKKHCGGDRPKCRVAKCASTCSVTTKTATPSHADSCDSIANCKATLPTLCRYGFTIGNLSKLSGMDVTSRKRTCNDFCKILGNAVMEGNTLHTLAHKIIPEFLFKIREPFIWLNVALWSLSLFYLFCVMVGRLDVLHIKSHLRSPSSHRITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Y5</accession>
    <name>A0A061D5Y5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768159.1">
        <property type="nucleotide sequence ID" value="XM_012912705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Y5"/>
    <dbReference type="GeneID" id="24564514"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211200"/>
    <dbReference type="OMA" id="FIPMYYV"/>
    <dbReference type="OrthoDB" id="365914at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="693" mass="79438" checksum="4ED77D054C562CAA" modified="2014-09-03" version="1">MADDDAPPAAEMEPDIVERLIGDGSNAVRRTRSSQRSTVSRNYTEDDYDGLSEEDNSDDEEYDADDVDEDDNIDDSEQDFEYIDERPHSIVTQTDQSDIDVDDTYRRPMDSRRFTESTTESFQTNIGTLGNAEHLLQDAHNLYYSHMPRVLGTNFRFQVGEVAYAKWHGELNVVVIHFVSQKLITVIDEAEPSVPDPSAPEPTAEPTANAGAKRRGRANKSRRSAGDDAMAFDKFGSSDDTDITDDGDYEYEPESSVENEVTSSSRAGTDAGAKQAAHAPAYRFEEEVDNNLPLFNDPSSTRLYAEVNEMQALPLRIDKDAPADVLEYGEDADRLEEEMSRPTRTLKRYFIPMYFVSFPGYKKKCAKTFRFWVKEKDLIKFNTVKPAPGKHAKVLAVERWESTEEPDETWEERDVQDINEYVYEVVYNVYNNNKMNSKFKAPEHLPWCLPVSLQRLVKSEHARILQAQKKNLNFYSIEIADAFSVAPLTERLSAYAIVQNFKYILILMNTLVSKHGGRKTNSKTKADLANAIRSSVENDVVDEVDVPSLRFMEQLETSIGSELNAQQFHEIYVNNIYWLDIYLDYMDKLYLHTHCYTEKEHEFLYMTTHSEDRSLSRILGLEHLVRMFCYPVLYNELLKRVTADGEPLQVYMPITQLLLHYLAFVATDYTHSQKYMPSHLEGGLFKISHLKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D602</accession>
    <name>A0A061D602_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766525.1">
        <property type="nucleotide sequence ID" value="XM_012911071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D602"/>
    <dbReference type="GeneID" id="24562880"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106480"/>
    <dbReference type="OrthoDB" id="361043at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="1">
        <location>
            <begin position="81"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="291" mass="33529" checksum="30BD782AE9002799" modified="2014-09-03" version="1">MRLRSSQVWRFATVDRASRWRPFGEAKDSTARNKGWKQQQSNTDSIGVTAKKMARSRVDDEARWVSLIEEAKVNIASLTPMDIALLVNALTRVLRADSGLYEMLRDRITHMMAFFSTQHLAMIISAYVKAGLMEQSLYDSLKAEINQRMYELSTPTEICMILNAVARYKDRDEQFLVKLAAHTTHHITEFLTEEIALLASRYHALDIYDKALFDAIEERVTRHVGRFLTNDAIATLAAFSHFDAENERIRELLKKHIKEQREYLDAEDYAERIRSANLSPEDRADLLNSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D616</accession>
    <name>A0A061D616_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BT1 domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0211480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768189.1">
        <property type="nucleotide sequence ID" value="XM_012912735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D616"/>
    <dbReference type="STRING" id="5866.A0A061D616"/>
    <dbReference type="GeneID" id="24564544"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211480"/>
    <dbReference type="OMA" id="GIDDHWF"/>
    <dbReference type="OrthoDB" id="754047at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17484">
        <property type="entry name" value="MFS_FBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF0">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="507" mass="56341" checksum="0FE87B210959CADB" modified="2014-09-03" version="1">MCGRGYAVGVPRRRVLSHPEGCSIMHKCVIGHLADDTDSVLFVNPKIYKATPDGSPRPVESGNDLPLYTSPRRRSYNEVISCVIAMLHGVEVFTSLPILYLYKDDFKLGPAMLIFILGIIRIPMNVKILFAFMSDGVPLFGSRRRSYLIIGSMLCLASNVTLGFCAHLSLLWTTVLLAVSSLGMALCSVIGEALIIETGRRQSNDQVTRTISTFCAFRKITFAGMSYLSSVLIMMMAKQQLFLMCSVIPLIVVISAFFIVEDYTHPQLSVKEQWTKLVNFVGKPEIKRPSTFLFISMLVPSAGTALFYFMTEELHFDPELFGRFAAIQAFASLIGVYCYAYIFRDCSIRKLFVWTTLLVSMCCLLSIVLVERWNLKLGIPDTAFVITDSSLLQLVGEINSLPIFIMATRLCPPGIESSMYSFLWTAQFLGLDVSTYLSSLLTYAFGISANHFGGLVQLIVLCAVAHIIPIFYVHLLPDSIPKTIEDDEAETRPCLQDGGAAEEGREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D633</accession>
    <name>A0A061D633_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flavodoxin domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0106880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766565.1">
        <property type="nucleotide sequence ID" value="XM_012911111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D633"/>
    <dbReference type="STRING" id="5866.A0A061D633"/>
    <dbReference type="GeneID" id="24562920"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106880"/>
    <dbReference type="OMA" id="DIMSIPR"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="625" mass="70365" checksum="45632F2C6677E16F" modified="2014-09-03" version="1">MRVLIVYATETGCAEALAYSTYIQLKLRRVDVSVKSAAVATRRLFMAFDRLVFMVSTAAYGEFPHSMRFMVDELQGGRRKLPVEYTIFGLGDSRYPLFNYAARKLVTLLEMAGANCFYGVGYGDDQHPLGHTGEFIPWIAGLTALWGPLEAYEEMPTTFRLKVEQLEAGTVEAEIRLNTAVGTVISNDVITANDHFRTVRNIVIQCYGQKYGPGDVCCVYPTGNPDEVVEMLQKLGQDPEQVVSIRSANDDGLEFNRDLEVLHVSDEGGGSHEGSRLPFEGKAISLRTLFVEYLSLKNVCTQWQMYFMAKHATLDIYRNKLSEMASFSIEACAEYNRYCKDERRSLFEVLCDFHLTNLPVEVLVNIATPYYPRMYSISSTPTTVGIARLWPSPCDGTLIGPHYSTLKSFLAQKSRETGLIELCVADVTHHTPYNRKVKGQASDFLANALPSRLLRLTITKSRIAEAVLDVTKPVLFICTGTGLAAVKPLMEARVERLANIWNEAFTLPHVRDMAFIGFRRRRQDHLYLANAQLLNPWCEVHVVYSREAGRKIYVQDEIVKFPKRVIEIVMNGLVIISGRSHPMPKQVMQRLRDMLVEHAGFGVRAAEKFMEGALMGGKIIMETWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6B5</accession>
    <name>A0A061D6B5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768417.1">
        <property type="nucleotide sequence ID" value="XM_012912963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6B5"/>
    <dbReference type="GeneID" id="24564772"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301350"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="64" mass="6778" checksum="018704E0C9889E59" modified="2014-09-03" version="1">MANSGRFVDELASNADASQKFSEIAEAVVANTCSTKTGSKKLKSPSHTRVTAKQSSPCSTTLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6L6</accession>
    <name>A0A061D6L6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766775.1">
        <property type="nucleotide sequence ID" value="XM_012911321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6L6"/>
    <dbReference type="GeneID" id="24563130"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108870"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="6697" checksum="6517E624688C9732" modified="2014-09-03" version="1">MSHLSCNNDIIRKPRQLSGAIHPPQPKPLCTSISNLDANQRNKPELHFNLMICTRIYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Y3</accession>
    <name>A0A061D6Y3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0109870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766875.1">
        <property type="nucleotide sequence ID" value="XM_012911421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Y3"/>
    <dbReference type="STRING" id="5866.A0A061D6Y3"/>
    <dbReference type="GeneID" id="24563230"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109870"/>
    <dbReference type="OMA" id="IQVHGWT"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="172" mass="19201" checksum="E74C45498E36C0E9" modified="2014-09-03" version="1">MRDSHGSHSYVLNKPTKIEFHKVRILILDAPNNSNVELYLHEMLAFGVTCLVRTCETSYDCTPITAANIAIRELIFNDGEAPSDAIVAEWLQILKDVVANNGSVAVHCVAGLGRAPVLACVALVEYGMHPLDAICFVRERRKGAINRKQLEYLKSYKTRKNSPLCLRLCPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D745</accession>
    <name>A0A061D745_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768529.1">
        <property type="nucleotide sequence ID" value="XM_012913075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D745"/>
    <dbReference type="STRING" id="5866.A0A061D745"/>
    <dbReference type="GeneID" id="24564884"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302470"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="167" mass="18145" checksum="99E4B7D2C1753314" modified="2014-09-03" version="1">MSVDEIAESLSSLSLQGNANFRSARGEVYTVDTATGETFIKGTQRKDGSYRRDIKDEQGTYVPRFRRSPQTATPACIATDEAKKHGEVQSAEVKGRSWRSVPRSTDRKERKDIVTVSAASDGKTNEGVAQRRISDVASPSWRKPDSTSSRSANTASAVADDESAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D795</accession>
    <name>A0A061D795_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768594.1">
        <property type="nucleotide sequence ID" value="XM_012913140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D795"/>
    <dbReference type="GeneID" id="24564949"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303120"/>
    <dbReference type="OrthoDB" id="10410846at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="126" mass="14451" checksum="4E65628C6604F1EE" modified="2014-09-03" version="1">MKAILTSENLERAMRSDAGQKVIDGVILAIMWHIWLTYFVPLILAKGFCVSLVFSVYYFGWLGRFRARFFRGLTLFLEIVLYCVWKLCKALAALLKSLYSNGNSEGYGMLRGYGYNPLVFDANDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7I2</accession>
    <name>A0A061D7I2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RNA-binding domain NOB1 protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0210900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768128.1">
        <property type="nucleotide sequence ID" value="XM_012912674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7I2"/>
    <dbReference type="STRING" id="5866.A0A061D7I2"/>
    <dbReference type="GeneID" id="24564483"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210900"/>
    <dbReference type="OMA" id="DYAMQNT"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="12">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="11">
        <location>
            <begin position="232"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="387" mass="42310" checksum="4E5FB4C72B53D583" modified="2014-09-03" version="1">MEEPTDSAGASGALEAVSPPEPAAPASADTEAPRRKLVVDTGAYNRSTYLDRSGDELFVTRGVMKEIERFKDKNPVGTHIRTVFKVTERDPVEEDIAKVKKFAALTGDLPFLSANDIGCIALTLRLQVESGDTSRLRSEPLPLSLTKTGSKAEKNEAGKKRGGRNKPKKGGSESGVGFDCWITPENVHSYNISAAAPESHQKVACMTTDFAMQNVLLHMGLNVVTLDGFAAKSVRSWGHLCRACLEVFPNTLRQFCSNCGNATVDRVPLVVDGQTGQVTVKDTRKWINTRGTIYTQPKPVTGKSKQMYIVAEDQLMMPRYRNQLRIMNRKSGNDDVSHFNADECTIGAALGGPEKQLPALARVPVGLGRGNPNSNHWMMKHKRAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J7</accession>
    <name>A0A061D7J7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin_bind_4 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767045.1">
        <property type="nucleotide sequence ID" value="XM_012911591.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7J7"/>
    <dbReference type="GeneID" id="24563400"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200160"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1541"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1615" mass="178686" checksum="54D3B498E0C49B9B" modified="2014-09-03" version="1">MENIRLRTLKDCLQFFEWLKRDEGMKSSVASELASRYGNYYNHVSLTGTLPVPFSEFLTNVSKFYHKLAKSPTAGKYTGKSSQEITSALFECMPKFLAALYYLLYNVDYKYAAVGGSYWEDLYPGWDAERRGWWGNYPESGGALQQYLRLSISFQLELIPGGFSYGELTYGYDFSAKFAYPRGKNMVGDLERILNKTTHNYFRDVFATSVLVDAGANKVNTANSLALVNLFCEIVAAAEKRNQGGEELKQTLNDHFKPKCINWTELSSHCSMIKMECKKIFRNDGFSYTGQSPVLEALNTREFGKRTAKWLAENLENVRQNVIKINKSFPVDDTTKKPKLAEFVTNHVFPYGFIFGDTSYGTLGKAYKTLTHHWRTVLEMLGKDDDGLDKLRKLLEGEGCEAAKTSRPVAAAKPAPAKPAPEPQPSDGQDAGRQQNNVLHVILSGNGGGGGSSGGTGAGVNLQRTNNHAQSTQQTGPTGVRGPIGPPRPEVTSIPNPEAVNLAVTRAKSAVNGGGHDQGKKSEGAQNQGKKAEGGQGQAGGQIETNSPSSQVAQAAQTQTSSDSRAGSEPPGSPGPSGDQGRGAQAATSGAAQQNVHEAQPVSGDSSMASAGLSAGGAGGGGMEPTIPQTQPPSERNPCSKDRSRMMFGGRTICVPKSETTTSTFHPFHKAISKAWDASKAHYFPPSSPTYSNAQDIQGLRTQDINTPLVHTHQPIANLPSGRQITPQGARWSGKGNNPATHPDYDISRGSYSFYSPDGYAISDLSDATLGGVTMPDTSFEEEEKDRQKRLQAHDERQLFKEKANRQAYVNMQANDLIKSIEEVKKSKDKLMQETINQLLLAEQQKLITTGFDGQPVVDVGYVDGEEIKDDSPHKHEHESKLQFEAYDQATNIQRDRQKQWEQYYQEQNEKINNSEEKHQQEVKRTLDAIKYFKEVEYRRQREAAEAVTGVPLFSKTASNLLESPNYSTISTLPMVTGARIPKSNQLLPIPNGGFDTAMPPHPTIHLEIEKPHDSRIIYGIKEFDNSQTPTNSIEPALPDDTIPNMDPESDTDYSNNIGVFKNYGFTVDPNPNMCNNPWNYADDSATSPTLPPPPDSDHLPPPTNVKAMLFWLVGFNTYGLTAKTERHMEGILKEINSDTLYPKYALAITGDLPTLPASNIADTLTEACLYSAHVLNGIMRMKSNDVLSPIDFKSVYSQLRYSTDPAGLLCQLRDYVYACHHQLAFLKAQCKQGKSHGGWQDCNYGSDVSPTKSPLQSFLTDDWDSTFKTHLFDPSNLCHKSRIRMGFKAKDLPEKLQLGSVISSILTPSCGGEDPLLTLSSYLNCLTRRTPRTTGELVSYFHNFGMELYDFALDSLSQLDSSLTKSHPDCPDWDHLGDSDLQAVRGICGSESLISKHNSSHDKDHPNTLSTLVGCGSDADSCHPHCSPITYRAYALYSQSFAHTYLSWTVYLPDRLHESLQKLYYDLLKHKCSSDKFFHSCSTALPLLYLHGFTPPEVGSQVSLKCSDVIAKLKEIVNGKPIASLMTAMDNFLYTVREPFIFTLVALWSLAFLLFTNTMLYRLDVLRIRSHLIRTKASHRIDVKALLTKGRKMLSLYKDVDYFDEDTLSQFVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K5</accession>
    <name>A0A061D7K5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0100340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765891.1">
        <property type="nucleotide sequence ID" value="XM_012910437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7K5"/>
    <dbReference type="STRING" id="5866.A0A061D7K5"/>
    <dbReference type="GeneID" id="24562246"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100340"/>
    <dbReference type="OrthoDB" id="734at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="entry name" value="DNA gyrase/topoisomerase IV, subunit A, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050220">
        <property type="entry name" value="Type_II_DNA_Topoisomerases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF5">
        <property type="entry name" value="DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="GyrA/ParC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600664" description="DNA topoisomerase (ATP-hydrolyzing)" evidence="8">
        <location>
            <begin position="29"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="9">
        <location>
            <begin position="125"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="941"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120292" checksum="FD53CE341A34B855" modified="2014-09-03" version="1">MRTVHRRILEAFVCVVCFCLLGWCPAGAFRSPSAAVPLAAAGGLQTRPSLHGRVIRRIPAVYQASVDVEERSENVEVASDGGDVAGGSNAAAEEPRPPFEDLELCDEIRDSFMKYALSIILGRALPDARDGLKVVHRRILWAMQELKLSASTAYRKCAKVVGDVLGRYHPHSDKSVYDALCRLSQRFMMRVPLVDGHGNFGSADDPPAAMRYTECRLSAFSESLLLADVGRDTVDMLPNFDSTELEPTVLPSKVPMLLINGSSGIAVGLATSIPPHNPDEILSAAALMARSHGDVDPEVLMHIVRGPDFPTGGHISTTMDNMRKIYTTGKGSIMLQAKFSYEERIKPRNSKRESDIVVNTYSKLSHLTFSAGSRVSIIVNELPYNVRVRDVLMSISKAVETGSLRGITDLRDESDRSGIRLVIDLKKHVTTHMEVEEIMNKLKRMSGLCSFFKCNFVALDSSGTRPVRLSLYSALRIWLDFRVQTVRRRTMHLLREAKERLNLVKGFVIASNHIEEIIRMIRASPSPADARKALADKRYGALKGEQASAVLRMTLSQLSKMEREKFEKEESALKETIERYNSLLNDDQSIYALIASELENIQQQRRKHYNLKRRCTTLSVAGRPKINLGDILRDVSAPQDASTGGASVLPGEEDGATSDSGSDSESQYDEAYDYNGDGESESEDDQSYHKDPSLLVLNDLGWIQRIKFDNMFFTSGRSRSIYSPRVYQAQVAQYSINSESAEPEESPESLNEKVRLNYATCKPGDMALLIGTDGMCVTFPVSKLRICSRGYSMWKSLGVERTEKIAHFMVTSKLRSGSAEDGDHTDKKKLLLEDPEGFLIVGFADGDVSVMRSSVLEGIRLNKFGVSKMRLWKDERPDPVFALLAGSKDDIILGTAQGYVLRVHVETLLRGLGSRARTRRKVIRLKENDVVTCGALLEPSTEDPNLEDGILTDTASKGAYGHDQPDDSQTDGSAPVALNGADEAMPTGRHLMLLSRSGKGKLIPVSEVKVNRHCGLGYDIMRNSKSAVDALVAIVPVEPEDHVLLVSEGGILARKDPFALRPGLRHHKTRNFWSRIHGTDVVKFAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7V5</accession>
    <name>A0A061D7V5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768263.1">
        <property type="nucleotide sequence ID" value="XM_012912809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7V5"/>
    <dbReference type="GeneID" id="24564618"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212190"/>
    <dbReference type="OMA" id="GFVEIRI"/>
    <dbReference type="OrthoDB" id="366400at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="846" mass="91388" checksum="CDACABE75044006D" modified="2014-09-03" version="1">MAAAERGSTSSAGTGNTATTASATAASDASGGAKGKAQPKLPRTYTHQVLVGFLNDVFSSCTFTTCPNIPGNLVDLVKESPAPEGRHMLVLRLEKKGLMYEVVRHNFDSALKGFIALIQYTGGAPPTGKVNTKAEVLASGLALAFRKHMTCPTTLNQVSTSILKSFVDKPLNRGGLWAYMSLPCFLGSESADPTTLKERRERILSYAEEGMPPISDITIVSLLRVLFYLKAEQFLRPLCAVLCQEYLKNYSDASDLIHVFYFGSSSGVLSGDYVARHVNSGFNTVNVLSSLASSELVLLLSCFKNASALDMLPLRKVLMILTEAVETLSATCALCLLCVLVKLEFNFESSSHFSRLLLTVLARSFDNVPLDAVQLVCGLGFVGLDYPHFNQVLDHVLVKFHLIEHRNLILTGASYAFAHRLMSDGELLKLDAPRSEHISHCLEFYVKNVLAKTMSDNYHLVGYYCDVLDEMSTFSSSAKGADGATNTKASAQRSSKIASGSPSSSAFAANPSMGARSYGEISASVHSSKLYYLNLFEDCCLRYEELDFESLCLFLFSLLTFNMDISPLHEAMLVAQDLMLRKGYNPVQIQVVPASEMDRQHEMCYAILQYSQNPSDSDAPLKFGDVQSHCAPLPVAEVAAPEPAASPPPEAELETTAAPAPPAEPAAETPAAPSTPLPVEESVSSSEATPTPVTPERKPTDIKPGDALSKALPSLGIALDGSTDPSKLTVEGLLGTLMSIVSPTAVPKAPASKKASKKSKGVARGKAPPKAAEPVKKAVQERSGKRKGAKKAPEPVKEEQRLPQPELSATSKLLYAIRREYRYRARLVKHRVSISYSFEKVQGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D824</accession>
    <name>A0A061D824_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B-block binding subunit of TFIIIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768879.1">
        <property type="nucleotide sequence ID" value="XM_012913425.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565234"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305970"/>
    <dbReference type="OMA" id="IFAWCPQ"/>
    <dbReference type="OrthoDB" id="431852at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1782" mass="201385" checksum="DBFBF5DB16CB1473" modified="2014-09-03" version="1">MEELNPRISGRPDDGFEDKAELTSSHQSVLWFHYRYFAVGRLPPLVRELCFNRPTEALDERMLKVLHESDNQIILEDEWRDAYYAMLTEKLPWANPNVNDRTIKKSFVFFRRLLESKCKITRVFAWCPQSNTFERCVIPYGNAAELPESLEHLPAPGSKLRVVNMGAPRPAVAPDAAAAADDPQPEPDPALAVTFYQSPHLFFGHNLKEWVYYLVRCHKGGASVNDVKPYMSLPYKVVTKTLSSLAAANVLSKVIARDGKLLMHIYSIPGGEAIEVRANQAQSATAKGKAQTTAASAATAEQSNEESRPAKRQRKPHTIGGVRINADDDAHVVPPQPTPSGPGAATGVREDAPETTSAPNSSTVVPELEPMNKRYCVWLTSERSLYPNEAAYEERFKALFGTECNLPKHVNTAIFRRRMVLLSDYVEDFQATSCNNISVMYGDMEPHTGKTVDRKTVLRVGKYVQENRPHICLTQGHELKGVSYSLVVLYDSRRLNAFKAFQLVNNEITKRRQIKSTLTAHLRYRINESFKSPDSLPAPPKDAVNPAPEFTTGPMHLMPTTLVKDIAVTMKRARETENKPRRAFSASIQTTNGFIRPIVTRVKCLHSYLLDFAGDGRKFTATQALQNMPIDLYLQVIGCGYPLRNVYDLLEGNILRVHLDDDLYNALYLNSGGRAAIQLLRRLLAILSGIGLVRVIATPVERPNDNVVPECTLEWEVCRNVALRSLEDETQVVARFNMFKEADGFWEALRAEVEAYSSQEGREVPDHMPIQALFNPKQWKRSAFFRNVYHSHIDGTITSWLRLTFHGLDYRKLAKVMYMPDYLMDLVCQNYNVSHDHLYKHLSHRIRNIGVQSAHIGVPKSAVIYAKNMSVDDECVWLAKFVLAERMCNAMFYGKLKDSKNQSFCSPVTWGALRQKMITAMRSESAHRKRHRIAAGPPGSDQVTNSAEAAPAGSITPYDKEWRRKFNDGDTDPAELGELYAKALEYKNVMRSEDDLPKVDSIDSKSTISDVSDSDPEESELSGDSDVELETTEPQPLDRIWTFLSLMFDGKFNAAACRYVFEYIIGKSLLSPRMLRRMRQLCSSDVYISLKHHSHMYRILTNESTAYDHLKCHLKSLLFSPIMCMRPWFLKSEPDFRRGRNILRQWCEKGWVVNTKESTNMYTYFKLSTFAKGRLFGKYSEYEFNYNLLDSHIVMYRGSLAASAIAASDSERHQIPGSELGASISPAFTPGFMRPSDELSMHDIYSMMNHFVNGNLSFLPLWGPEDVEEPPVAKRVKVSYERLNDGGISRHLRDCTPNVPTVVSVTVGLCAPCPMPQLPRVNKSGPKTRAHNENFAYELERNREIVCGGRISEVLSPISCSSRLFGSRISCRYPLCNFEYSTDRDRGWWAGRSFTLVPVVEKALFADARSSQQGNRAAGAAPRYTGQTYSKGYKGALPIYAYFPQPTFGAPGQMAPKPAPKPIAATPSLGLLSDLLVRMIRSLYGTPVLELEDRLLYLETGVYRVVCMVQVTESYGILESDLFAKFALLYDVVFKDEPVVINKQSTTLLRAAFEVLVATAEVLRFVSRVPRNEEFAYYYWAHCEATYVKRQRIVGIRFHGTYQTPEPEEVTAVVFERPEYIPPLLWMIYEDPAALMLTPEKLAADLGRLAELVCDTEVFIRYLEHRLKSPLCSFVSLDGHLNRVLVSFLMLRIASLLKTVPGQTVVEVWEKLVILDLCEVKLVIQGMIALGICHRKPLASSFTRGVARSGVDSGACYLHFLNEDSSWLQKFYHVLYPYTNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D894</accession>
    <name>A0A061D894_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sun-family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0102760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766136.1">
        <property type="nucleotide sequence ID" value="XM_012910682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D894"/>
    <dbReference type="STRING" id="5866.A0A061D894"/>
    <dbReference type="GeneID" id="24562491"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102760"/>
    <dbReference type="OMA" id="PDAKWKL"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF54">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_82, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="384" mass="44040" checksum="8AD902F1EB7AEA73" modified="2014-09-03" version="1">MLGINAQRARYLENALEVYTKLNTGNLPIDTFLRYYFRVNRVASGSRAWIAEHVYEVQRWKGLIAHLSPKPVTWTGMLNTYLLHQRWRYMTGHKGLPPHLRCSFPEPLFERIERQYGVDKALEICQILNEEPVTYLRVNTLRSSRDKAYKSLLHKGVPVEKCADSPCGLLLSNKKTLLESPEYHKGLVEIQDLSSQICGLKVEAQPGEHVLDYCAGSGGKALIFGPQMENKGRIYLHDVNENLLLKAKRRLKRAGIRNYFIMDPNIANTRQYYGKMDCVVADVPCSGVGAFRRNPDRKWTFTVEQVTEYTALQRSIVDNALLFLKPGGRLVYITCSIFEEENELQVNYFCKRHGLVHAQPVTLQLPESRGMNGYFLAVLQREKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8E4</accession>
    <name>A0A061D8E4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic</fullName>
            <ecNumber evidence="11">1.17.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0103290</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26119"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.1" evidence="11"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766196.1">
        <property type="nucleotide sequence ID" value="XM_012910742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8E4"/>
    <dbReference type="STRING" id="5866.A0A061D8E4"/>
    <dbReference type="GeneID" id="24562551"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103290"/>
    <dbReference type="OMA" id="LYVGKEC"/>
    <dbReference type="OrthoDB" id="429167at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000005">
        <property type="entry name" value="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000006">
        <property type="entry name" value="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017178">
        <property type="entry name" value="IspG_atypical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058579">
        <property type="entry name" value="IspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058578">
        <property type="entry name" value="IspG_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="4-HYDROXY-3-METHYLBUT-2-EN-1-YL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454:SF0">
        <property type="entry name" value="4-HYDROXY-3-METHYLBUT-2-EN-1-YL DIPHOSPHATE SYNTHASE (FERREDOXIN), CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26540">
        <property type="entry name" value="GcpE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037336">
        <property type="entry name" value="IspG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596079" description="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic" evidence="14">
        <location>
            <begin position="21"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="IspG TIM-barrel" evidence="15">
        <location>
            <begin position="91"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="IspG C-terminal" evidence="16">
        <location>
            <begin position="683"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF26540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR94010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="780" mass="86119" checksum="1BD049D8388EACF8" modified="2014-09-03" version="1">MGIWHLVVYVAAAALTTVEALRRGESALTFVSLTPSQKHVDGGRSLSSADIAGAADGRSRNSLRAAASTKSAPFSDNVYCESVTERVRFPTRAVKVGNVTIGGGNPIALQTMTSSDTNDVEATVDQIIRCQQYGAALVRLTVQSPREARASVIIKEKLLAKGCHIPLVADIHFSPKVALMAAETFDKVRVNPGNYVDGRKDWDEKVYETEAEFKEGAKKIEEVFTPLVEKCKLLKRAIRIGTNHGSLSSRIMSYYGDSPKGMVMSAMEFADICVKNDFHDMVFSMKSSNSFVMVHAYRLLVNEMYKRGWNYPIHLGVTEAGSVDDGRIKSSLGIGALLLDGIGDTIRMSLTEDPWLELAPARKLVNYVESLQQNTKSETKRAVMREDFRDFNNIARRDLEFGDSILKFEEGKSTILNPDGSVGCFVTHEDLADPVTLYKALNVVMQDGLPHRGLKSVDFVYMEDTPMFHDSNGQRVLKELIEGGFQVLAPVDQLQEQPIKFAIGVVDLLKLEEFQKSQSYPNYPHADSRIDFTDKIADLAVRITGHEPDAAIEKLCSIGRGISSKALGSGIPRFIVLDIDPKLNHVETVRRIFGILIKNGSKLPVIHQVDATECFDHEEVVIRVSAALSTHLIDKLGEGLIIKSRLPLSESNDIALSTLQVFNSVNPSIPRLQAARMRSFKTEFISCPSCGRTLFDIQKTTENIKKRVGHLPGVSIAIMGCIVNGIGEMADADFGYVGGAPNKVDLYVKKKLVERNIPHEEACDRLIDLIKRHGKWVDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K3</accession>
    <name>A0A061D8K3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0307470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769029.1">
        <property type="nucleotide sequence ID" value="XM_012913575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8K3"/>
    <dbReference type="STRING" id="5866.A0A061D8K3"/>
    <dbReference type="GeneID" id="24565384"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307470"/>
    <dbReference type="OMA" id="MPIRTEG"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="173" mass="19119" checksum="A3403C09B48C11C0" modified="2014-09-03" version="1">MAMIALFITNQHGSLIYYKSLNGRDAFSSNDAIRLASTLHGLSTIAPKLCVPNSAQVQTLLPQPKGNGFRPPPERHAGITCIESSSFRLQCYETLTGRDDIGPAVAHLSLGLKICIVCTPQGPSREHVNVILSYVYELYADFVQKCPFHQTDMPVRSELFDDRITAYFAELST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K7</accession>
    <name>A0A061D8K7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767430.1">
        <property type="nucleotide sequence ID" value="XM_012911976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8K7"/>
    <dbReference type="STRING" id="5866.A0A061D8K7"/>
    <dbReference type="GeneID" id="24563785"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204020"/>
    <dbReference type="OMA" id="NKQHAPK"/>
    <dbReference type="OrthoDB" id="361343at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="24111" checksum="EA76129BA523347F" modified="2014-09-03" version="1">MSPSYISLPIGAMHQCGEDDNEEVDFEGWLQVASHNRCMSGESVMKCHSGSAGAKACNSCVETVCCRKHAVDGGHVVSRGDRSCTPRNCVNIVKRQGAKVCRCKGFEVSHAEQDDVFYVNNKQHAPKILVQKPQTVIVRNHSRPPIVVQQPPPNVIVKNDPPQPVYVQNCPPNVVVKNERPSSVLKTPAMPMKFPQVYQSGYPPNYMKPCNCARHGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8R3</accession>
    <name>A0A061D8R3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0302410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768523.1">
        <property type="nucleotide sequence ID" value="XM_012913069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8R3"/>
    <dbReference type="STRING" id="5866.A0A061D8R3"/>
    <dbReference type="GeneID" id="24564878"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302410"/>
    <dbReference type="OMA" id="LWWEKKI"/>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596101" evidence="5">
        <location>
            <begin position="37"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="174"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="895" mass="101259" checksum="37A663E2B8BC17B2" modified="2014-09-03" version="1">MGRYVLSLVHTIRTLVTATCLAHCFLLLDLPRPCAASGLLHRYRGNQKHLGPDVGLQRSQFGARVPAFVANNVRSDGLFASDSRLFASGRFSFDPAVVKKRRRSSLSKQSNKSKNRWESQHSTMHELANLSSDHPTKEALRQVSLEEFVRRIEKRPERKRIPRPAEAHEPWYDAVVYLKGLPYEATEDDIQSWLSGYDIICVVLIKNENGCFTGDAYVRCSNIEERDRLQREMTGKTLGTRYVPMYRVTESAYLEYYRTGFRREPAKRNYIAPQLLVMKHGVGIEPTDVCSLKSGSRICGVVTNIYRNGVLVDCSVYESVGGLRERVFCVLMRNRIARNVGLLGQQREWLRTKDLVLFPGIKLNLYVEKVRQTTAQSSFDEDLWREHFGEPFESLNAPSSLPKRSMVYLTMDSSVSDDKVQWWERRLVDTYAKFTLHDSDIPDRIHDEEVFQRVAVGDTWLGGRPHVKRSEVAAGRVSIGGNKKIVDTTSTFDREAEEPDPPDNVDGPAYHELVREFMRDSDVDKYGTRYHGFEDAEAGLDTTEIRGEPTMEPILLNVDSPNEPAVFDDAEMSEAGSSTSTDVPFDTSTGASRVSFQRTKVSSNAPSLVLGNAADEGGPGELRRFAFREIDVPPTSMMPADNLDGLNVIEDLRRKTIAEELKVLPRTTLFDECIQLPGSGWLLRRSDVPKLAEVQVVAILRQLGKEAVKGAENSDFQNRMLLCQVIKEQGLGTGLDPKTLIAKGLYKVKQSKKKLKRIIELTKNLTGRRFTREDLDAASKSELQMLAEESLRKFAQWNPVEDVKRVFVEMYGGILSSLPEDASLEERWEALKWHVVLEIYGEQSDLKEILRDIEENDRMLGQHVESPSDVLGELVKGSIEQMCSERHAEHEPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S2</accession>
    <name>A0A061D8S2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0302560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768538.1">
        <property type="nucleotide sequence ID" value="XM_012913084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8S2"/>
    <dbReference type="STRING" id="5866.A0A061D8S2"/>
    <dbReference type="GeneID" id="24564893"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302560"/>
    <dbReference type="OMA" id="NCMVFAN"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="144"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="299"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="425" mass="49109" checksum="716BA25A0028BB20" modified="2014-09-03" version="1">MEADGRLMKRRRHDIHSSASTTSESRRVESVEDLENYVTEEDCVFVAIKTEHHTKFAEKGFFRALAKNHKKILATTRWGDYEIPDDARRYVLRGWDSLDSDLQDMIKAEAVAYHNFTSLRKYADMSIDECLRLLGDSHGVMVSFETVGHIAHLNLPAERLWAKKIIAKILLDKHKHIKTVVNKVREVDNEFRTMELELLGGVDDLVAVQHENTYRFKVDFRNVYWNSRLIQERERISDTFHMGDVLVDMFAGVGPFAMYAAGKGCLVFANDLNPVGARFIGINAALNNFTHLVHPYNLDARDFAKTVVEYGILDRDVSSVKDHTLQPESKIHFVMNLPKDAIEFMDVFRGIARHIPAERLRTCMVHCYCFSDSDNVELDINQRMENVLRYNVEHKKITRVRDVSPKKHMYCIEFNAPNELLCSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8X9</accession>
    <name>A0A061D8X9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nas2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767520.1">
        <property type="nucleotide sequence ID" value="XM_012912066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8X9"/>
    <dbReference type="STRING" id="5866.A0A061D8X9"/>
    <dbReference type="GeneID" id="24563875"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204920"/>
    <dbReference type="OMA" id="HNENNIC"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="10497" checksum="C2A4FEB31FD17326" modified="2014-09-03" version="1">MDDIEGLYRKRTSIEKEMEALLNFLNSKECKKVGMTGALIDEEQYPRADVDIYAVREARHRVRCLENDLRSIESQLQSALEELHQKWQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Y6</accession>
    <name>A0A061D8Y6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0205020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767530.1">
        <property type="nucleotide sequence ID" value="XM_012912076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Y6"/>
    <dbReference type="STRING" id="5866.A0A061D8Y6"/>
    <dbReference type="GeneID" id="24563885"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205020"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="536" mass="58445" checksum="BA7AFBDAA7F76B55" modified="2014-09-03" version="1">MNVAVDEFGKPFVILRQQEKKRLTGLDAHKANIMAAKAIASTLKTSLGPRGMDKIIVSPDGKVTVTNDGATILQKIEVEHQCAKLLVDLSKSQDEEIGDGTTGVVILAGALLERALRLLDKGLHPLRIADGYETACDIAIKRLEEIANEQDVSYSPVKNAEIYKKAAYTALGSKVVSSCQDHLADIAVSAVMAVQDKERRDVNLELIKIEAVTGGRLEDTCLVEGIVLTKEFSHSQMTKTVRDARIAILSCPFEPPKSKTKSRIEISTVEDYEKLQACEKQYFENMVQRVVDSKANVVICQWGFDDEANHLLMKKGISAVRWVGGAELELVAIATGGKIVGRFEDLDESKLGRAEVVREVATGTEHQEFIFIEKCQKTKSVTVLISGGNGVYVEETKRCIHDAICCVRNLVRDSRVLGGGGAPEIAASLAVEAAAVKLNTLEQFAVQAFSEALLEIPMALADNSGLNVFDMVAKATQMQRTNCHVGIDCLRGSVGDLRERGIFESLHSKVQQLSLATQVVKMILKIDDVICPTEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Y9</accession>
    <name>A0A061D8Y9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768623.1">
        <property type="nucleotide sequence ID" value="XM_012913169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Y9"/>
    <dbReference type="GeneID" id="24564978"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303410"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595580" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="133" mass="15037" checksum="00841C55BC6FCE5F" modified="2014-09-03" version="1">MAKMWTAIFLMIASMFSTEFGAAKLPLRFGLHELGKFRPLRETFILVEHMSTEGGFLKANKPYLAPLPFVANAGKDDGEKHITPCWLVVGQKCAIGPPMMDLVEARMNLLRQIIRPSEHMPFTVSQINKLFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D922</accession>
    <name>A0A061D922_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767575.1">
        <property type="nucleotide sequence ID" value="XM_012912121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D922"/>
    <dbReference type="STRING" id="5866.A0A061D922"/>
    <dbReference type="GeneID" id="24563930"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205470"/>
    <dbReference type="OMA" id="ALIRICV"/>
    <dbReference type="OrthoDB" id="362016at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="79474" checksum="E8F30345CBA6DEA4" modified="2014-09-03" version="1">MICMTALCGLNVGMLDDRVCSAIDNVKYTVKNTTITSDTLIQVLRCLYKFGDIPGLVEVLRQFTADVVFIKPTDVVALIRICVVHGKGSEVLPSLIDTSSEYIRSAFHALTLDDKLSYLLSCSDFCEHHEMVSLALTMYAANVANFDSGNWRTLKTVLTSLRLYKKFRTLENGSAMPKLASQSLEKVLECIEQLDRNYSLEHCDLISRTCYMLAVLCRNDKADDNVNALFRLLWNISGDDNANMFTTRSVIYIIRAMLLFRLGDSTVKRGFVSLVIIKGTRISLPDAVSCLKCIDDHDFTGISSQILSLISGFDSGSYASLLKCYARHSARLSTHVLEQLRSQFCAIYNRMSPLEFAQCFSYSVAMGLVDGPTLQMAVAYINKHSMHLRPREVSLLFHAFTKTRYIPPDNVIKIFYRVLQTNTTQIALDDMIRCYNFISKHRIHSFGITDFLFKAIEKLLDGQVPIYQLCFLAFATIRCRDRRFKTRVYSAIFECCKNMTMQQLCFICKTLAMSVCRNRDIYAKLCNQMRNHGSFGTQDIENIIAAIRHGNLPESFIQWILDECPMTPAQRFVLFGGDVDVEKLDDSEVLICIMSVRDKSRITFHNHVIKRLCTRICKMSSTISPYVAQAVTDALQNTGHLKPKLDRLLTKENKNEYCKRMRNHVNGVYRGDALPTRKSESLGFRSILFHPPHVHPYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D973</accession>
    <name>A0A061D973_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768718.1">
        <property type="nucleotide sequence ID" value="XM_012913264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D973"/>
    <dbReference type="GeneID" id="24565073"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304360"/>
    <dbReference type="OrthoDB" id="366455at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="307" mass="34100" checksum="9F38CC568A32417E" modified="2014-09-03" version="1">MKTMSYALTTRDIDCLERLQLELELESTYAVGNGQFGPSDAETMLPSSRNMPGHCELPLNTKDSAAELQEAVSSNINNTLNNSFFSIYGGINGIWDKNSSSANSWRNSAKELANRSTTFEDIFRRSFYDEYQSLFSHDENLERYSGFSSLASTDGTGLSERLIEDTLKTAFDLPPQENTPKPVEEHPVRAVQKNQRSAHPSSGKSRKGSKQPPRDEVKEPEANGRKEARAQEKKRPNAWKTNKNAGGTPHGAGSNARSEFTEAGSINNILEASEIWLRHTTGSNMYNKKGLLKKPFPNQDKFSLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L7</accession>
    <name>A0A061D9L7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0312740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769557.1">
        <property type="nucleotide sequence ID" value="XM_012914103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L7"/>
    <dbReference type="STRING" id="5866.A0A061D9L7"/>
    <dbReference type="GeneID" id="24565912"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312740"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="223" mass="26531" checksum="BD1D5A1C481840C1" modified="2014-09-03" version="1">MPMNVFRLAGDMCHLASLIILILKLKLSKNCLGISSRMQELYFIVFASRYLDLLFYYISLYNTVFKVLFLLTTAYTVYLIRFSAPIAQTYNRKMDRFPYEKYLLGPVFVLAVFTTNRYRVLDIMWTYSIWLESVAILPQLTMLYQQREVENITSHYVVTMGLYRALYLLNWGYRYFFETPPYICKVCWIAGIIQTALYADFFYYFAKSKWYGKRLVLPFTGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA27</accession>
    <name>A0A061DA27_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769564.1">
        <property type="nucleotide sequence ID" value="XM_012914110.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DA27"/>
    <dbReference type="GeneID" id="24565919"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312810"/>
    <dbReference type="OMA" id="QENDHEP"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="938"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1352"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1368"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1681" mass="188337" checksum="DCA1074FF63CD874" modified="2014-09-03" version="1">MAVKGNVPEFKTLKECLEFLEWLRKNNDMKGRVSNRLIRLLKDRYKEAKQGDIEHALSQFLNIVNTFHAKLCKKAEPAKYKRINAVEALEALIQCIPKFLSVMYFLQYQVDRRFSAVGGGKWANLQVGMLDLYARIVRQPDQLMQHATAIEKYFVTRNGSEYGVIPGGFYPGDLKPISQGGYSEGHLMVNDLGTLLDKHSNPNNLFRDVFVTSVVSKNSSVETSNVANAIRLVEDFCGIFRDVKDEQDFKNNLQSRNNCISWLELKDHCIKLKGPLEKIFKNDRFSFTGYARIYKYLNKEKIATKMAKWLKNNLEALRRTLAGIRPEQNVNKFAITYLFPYGFTFNGYNFGTRTNSYKARKSDWDSAIEELKKNNEGLHELKRILDGTICQVRQENDHEPESDDEPVPEDLEYVEAEDDDKPLPAKTEAAKPVVTKVEATKPADTRSQSAEYGHDQDLGKKSEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGTTNQPGGQSDGNGSSAGTPSPGDPVTSSGQDLGGQGYASGAGQTRGPDDLSDSATASTKGPSAAGPSQGGGGSEGDEGHSRSSLAQERHKEIEAKFRQQNARRNNKAAETDQWLREAFDAVEKRKAEQQKRLNAQRELQKWKTLQYYDPKESTRPPHSAIHDVPVALDGDSLSNESNDPGISWERAHKDAWKLPAELLKAIEKREKEKFRTNLQEAKRAVFQQQNDNWIAREFHGDDIGEVVSLPPEVEVYRPTTQQHAERNAPSLINLVVDTPDMKDVVDHQMWPQTAIQDDFDIRSSRKSAFPTEITEPIPGAQIGMDPILDPPDVLVSHPPKVNKTNMVAEDLFSAVSRSLSIDVPKRPFQDRLHDVELDDTDANMADVLRNEIKHPDAWYGYDKGFSALPKSNFDLGLTSPLLTPDGNGTGLSHDPSDGVSASGSDQQRSSGSAGSTSTSKASGLGVGEGGRVGEGDENGRHHVKTMAIIPPEKICVQPTLENLWKLSGKDGIQFCDPINKLPPRTQVFNRRPPDEIWSEHIQKEEKKQQMAEDQYKAHGSTLILDGSQPTDDVDAHQEPWWYSDPAYSEINGKTVDDDIQEQLKNEQEAEKLYWETKQKMLGDHIDQRNRLRERQKQDTLEIEEYRIHEENKVNQVLQNIQKEAEENESIAKGLDGQPVVALDGQEEPHYDYAKIKNDVDIHSAHQILQHDYDQRQLKLQTLHEESMKTIAEQKEIEDAAKVEAERIHAFNSSKFGISRAPTPRVKDPEIDFSIQTFHYEDRTINDVDLDDPYANTADILEDELKPAEDKGFSGLPNTNFDLNFAPERIGLEGYEDPGMPRDSPRKADERVINPFSTDECLNPWSVSTSTSSTDTVQPPTSPPPATDHLPPPKTVREMLHWFVGLNTQGYIGLISEHVKSILQDINKDASEFSDALEVTGDPDQLTASMVTAKLTEACLYSATVIYKIRHNNDFKAFSTFDFKKEYSQLHYAADPACLLCQLRDYIYACHHQLMFLKAQCNRGKSHGGWQNCKYGSDTKTPSPLQSFLTDGWDSDFETHPFDPCNLCRKSRVRMGFRKDDLPEISQQGSVISSILTPSCGGSDPLLTLASYLNCLTRRTPRTTGELVSYFHHFGIELHGYVSALSLLGTAITKSYDLMSNLLHIIVDGVIRSTLGISRCELQTKCAHALSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA47</accession>
    <name>A0A061DA47_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766806.1">
        <property type="nucleotide sequence ID" value="XM_012911352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA47"/>
    <dbReference type="STRING" id="5866.A0A061DA47"/>
    <dbReference type="GeneID" id="24563161"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109180"/>
    <dbReference type="OMA" id="LRNWSYI"/>
    <dbReference type="OrthoDB" id="364014at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="498" mass="56422" checksum="D927CDABD717BF67" modified="2014-09-03" version="1">MSTEPSPTVDFKAFADHQKKLLFDETEEFFRRHNLRLKKYILPVPLPSWASSLDEVLDTGVEHEPYSTIYRHQHFLKTRILRNWSYIAVETLWNVSDNPRNKNIPFDLRPLTKEIIKQLDTTNADIVDPEFSGLLVTLNTESFFDVPNPSYGTQKAQERDPAGQGEGPQGGRADAAENTAAPAEAQGAPESAGAGSSASTPVFKSKIIAGAIVECLMTNERCIRCIWLHPHLSKHSSRILLQAFLPRLMLEMFNVPSVMTENGPSAYHKFAYAMHNDLDMFPRQCWLLLASIKKMSLPRHYEPSTFEEHPVELEYGECHMDEAGHLLLPEFSGIVDDGVLASVGSECSVRSVACNCYTEKMKKSVDAQAWLDRLVGCTESYMCLMLPKRSEREMLGLHPRDGWRDLITEGLDRPLLEELLELLPVDSRDRFSHLYDPSVATVSVRCNANLNSDFEEWCKLRREDLIDVTSDTEVYMNVDGGEEEYNMASTTKRARSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA75</accession>
    <name>A0A061DA75_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ethanolamine phosphatidyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0109430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766831.1">
        <property type="nucleotide sequence ID" value="XM_012911377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA75"/>
    <dbReference type="STRING" id="5866.A0A061DA75"/>
    <dbReference type="GeneID" id="24563186"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109430"/>
    <dbReference type="OMA" id="CYFTFLV"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="398" mass="44557" checksum="BA00F968C5202B42" modified="2014-09-03" version="1">MECLTRIIPKANLPNLKKYKFQSGATTCLDALINRFWWTPVAHMLPRFVSPNVVTLMGGFCIFVTNFCIFTYMHRLESSTAPTWMPLLASVMTLLYLTFDGIDGKQARKLGMSSPLGQLLDHGLDAVVTVFYPYICCTLYPGGFTFITLLLVAIAPIHVLCTVWRESEFETFEYTNGVLGVTEANLLAIALQAVHYYVRPHFGVKVATLFGGHPLFAFLGAYFPRVHELHNAMIYLILAVAYSEGMCGVLGLAYRTSYRLQYLAFMLSAFVHSYSAYYLVYTLPAQSRVAGCIFASMFVAAVCVNNIVCLLSKSPMRCVHWGLLPQYMLLLQYYGVGLLRDYGLVLEPAAFHRVLLAAAVYGTVYLVYVFVKTICEITEYLQIPVLTVPASVRRAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA81</accession>
    <name>A0A061DA81_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766836.1">
        <property type="nucleotide sequence ID" value="XM_012911382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA81"/>
    <dbReference type="GeneID" id="24563191"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109480"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7266" checksum="F44B278BF5DCDB54" modified="2014-09-03" version="1">MNDLCANKLLRSAVERDAEGYLADEEIADVAAHRKAEDAQVEQDDGEDDGNDDGGDGGVGRGMVTSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB5</accession>
    <name>A0A061DAB5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methionine aminopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0401430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769837.1">
        <property type="nucleotide sequence ID" value="XM_012914383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAB5"/>
    <dbReference type="STRING" id="5866.A0A061DAB5"/>
    <dbReference type="GeneID" id="24566192"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401430"/>
    <dbReference type="OMA" id="INQGTHQ"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="408" mass="45949" checksum="9BDCC2D6B5D3CE33" modified="2014-09-03" version="1">MDSGRVCCGCSKNTKSTLACPVCRTKGNIKIFCSQSCFKSNWTTHNVIHELEPSAADVPGDKWDISLDPKLRRFRNFRFTGNLRPWPTTPQKTVPSHIACPDYAHDGNPKSEFDLKSAGTIRENSPEEIKLIRKACILGRKALDYAASLIAPGVTTDEIDTKVHDFIVKHNAYPSPLNYYGFPKSICTSVNEVVCHGIPDSRPLKDGDIINIDISVYLNGVHSDLNETYFVGEVDEDSRRLVTGTYVALMDTIKQCKPGMYYREIGNLINHIADDYNHYAGRLLRVTNMRKHFIRLACEAEVLMLYRLSVVRTYCGHGVGVEFHSLPNIPHYRKNKAIGILRPGHVFTIEPMLNLGGWRDVKWPDDWTAVTSDGKRSAQFEHTLLVTETGVEILTKRLPTSPPLQFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAF2</accession>
    <name>A0A061DAF2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0210170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768050.1">
        <property type="nucleotide sequence ID" value="XM_012912596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAF2"/>
    <dbReference type="STRING" id="5866.A0A061DAF2"/>
    <dbReference type="GeneID" id="24564405"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210170"/>
    <dbReference type="OMA" id="KCYDTIT"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="111" mass="12450" checksum="1E0E0AF12A079810" modified="2014-09-03" version="1">MDALVKEVNNLRQQYRELAAAHSQLLTQQNECTAELQILEADAKIYKSTGPVLTAQSKDDAMSTITKRIEYISNEIDEKAKAMSNLQGVIEEKCRTLDNMNAQHQRAAQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAH1</accession>
    <name>A0A061DAH1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COG complex component COG2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768075.1">
        <property type="nucleotide sequence ID" value="XM_012912621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAH1"/>
    <dbReference type="STRING" id="5866.A0A061DAH1"/>
    <dbReference type="GeneID" id="24564430"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210420"/>
    <dbReference type="OMA" id="YNLESSW"/>
    <dbReference type="OrthoDB" id="364453at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="2">
        <location>
            <begin position="849"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1043" mass="116142" checksum="46E5D081C78C9447" modified="2014-09-03" version="1">MLTVKPKADLADDAKNVELYNEAIEQLKSVSLQVRSPGEYVATRLESVSLDDIRRELKALLASCQSNASGILKPLVSTATPFNDTIESTIQSLLPFKDVLKESSRQLDIGRSSIKQRKSHIKLSLSRFVAVSYAKMALSTHLEAVKHLESISEEIIDTFATEDDVSVKSDANIVLRAIDALDRCARLVEKAGDVVKSDDDKRTVTNDWAILEVIPSEINRIQRLLKQGEHYENAITEYVNYCQKTLKEVDPEQLGLHEDVSIDPGKTNIENVLEMEKLLKWNELEELRSIYAVESASKSVLRLHASLIKLTDTCTKSEMTALFTLYTERSNICLQEDLNVTACRKPPRDIAAHVNGLCSLIKGGEQLRLPTAGCNTAILPFVDIFTQVFVKPILNTIVGELVQSEQGYVPLSPHGEANHFTNFVDMAIERLLHPQYSIAMQLLNDLAHAWGNDRFKVICIFDGIAKELLKHIEKHFSAIYFPIYVDRFASNLEAYDHLIENIEIAAGSYRHYLKWRGSDIPNTVSRCFSVGAVCDNFIENAARELTAEITTNGNITGKLHEGDGQTFYLPPSMVLHRQLLALFKHRNFFYHLVPQYLRGASEMFAEYVKYLQATVSKMESIYANESKDSTESGEAVTNAAYMLHDLDAIETAINSGSTDALSVTLSAMPVDARESDYGASFPRVAHTWDSSDSGQSSPKASSGSTSSGGTTSTYVSVDPNTPSQSPPNETEMDAHSKDLQSALDSSNLPSTIVLLEGKSDGDIVKAAMRRLEYPLQVAFKRLSFALSGVDADDTSRALTQRSRDLLDELWKEAHKSNDSHRSHEDGDNTTATAQGYADKLPTEDLADVRALVTFTKTSIELLYNFFNSAHEQIEALKYNLEYLVIQNLVSGATCSLQFLQSMPSKFRSATKQDVSKPSNYVKYTLVPLLSFKEFTSPSIPQDLARKILTQTVATLASEYRNQVLKLLQTVQNLNESLLNSKNVRVKEQGANYLIADLGLIRAQLKTDIAEFVHQCNTRMGIQQEHCEDLRILSVCIPDDAMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI6</accession>
    <name>A0A061DAI6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769178.1">
        <property type="nucleotide sequence ID" value="XM_012913724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI6"/>
    <dbReference type="GeneID" id="24565533"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308950"/>
    <dbReference type="OMA" id="EYTDERD"/>
    <dbReference type="OrthoDB" id="364683at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27602" checksum="219B44A08052415E" modified="2014-09-03" version="1">MVNITVNNQFGDCQPATLSLTNISDDITLSSICILIDNQFKCLKNEYTDERDPCEKFVLYSGNKALDNQCQLREYNPVGLPEITFYLYERSYLTVTVRVVKHVECCGLFCSPLLSNIFAQKYSFKLLDQETVLELKHNVLQKLGSYVNNRGDCLTLEDLRLVNKKAVVEDNLMVLRDLNNGKDAALLLLVPMGYRSRPVVRAAPAPAPVEEEEVAKATQPAERTPTPRCVAPVPEPEETESKQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAJ8</accession>
    <name>A0A061DAJ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IQ calmodulin-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0309100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769193.1">
        <property type="nucleotide sequence ID" value="XM_012913739.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAJ8"/>
    <dbReference type="GeneID" id="24565548"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309100"/>
    <dbReference type="OMA" id="TNGRMIC"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="1277"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="1320"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1632" mass="182218" checksum="E02ABD12573CEACD" modified="2014-09-03" version="1">MISTDGGSSGSHNEPRESNGAEGANTEDGIAALEDFYYVDGLAPRKVVEHIYRRYRRGHYFSYFGNVLFYLMPSRQRDMRREYEKHLFKAGDAEPHLFGLLNEILHLTVASQSRPMGRGYGLLSDHAGSAPKRRFDAADPQNQRRNCNVFVYGDSSFGQMDVAKHAVEYLSQSAHVIGLEPSGAMTEHITDVNDLLAMFGDYASHDSVYRNTQMTYKLNFDSDHKMTSISVVPNMATDISCTAVSSRFRSYLASRTEDAALRDVVVRPPTIFYALLRGSIQSNLRRWLATCKLTARDAKLILQMLPVHEESHHDWHLKTLERAIRILLKIGFSADEVQSIMQVLAAVLLFDTCTLLRDNYERDPQSGSSRSVSQVNSHRTDLSAKDSGGGSGRMSIRSDDPNASSRTATGRASQDGDGVINPKDILVFAADVLDIGFFRVPAKMLGSQEQLFRLELLSSESMAQLDNLSSALFVRLKVAIYRKINSFLDLKRGSAVQTTISIHCNAGSFPQSLHVDKHCDLELARRASEEVFVDKLITAAMQRSNASDGDLDMARRSRKAVAALSGVTGLLGKVVVIAHDKANGKGNKSSWQAANVATVEHSWHKVNYDISSIAQEEAQMFTIPSRVLRLFAYSKNKFIIDLLVSKRSLHNVSGACAGALSYMTFLDTTIADGDESHFIVCTSPTLARKLYSKHANQSDSARRSPDEDGQHKGDRPEAADDHQAEHEDEGDMTLLERALSTNVPMLKICVTQRDQSQVTLDISAALNAFLPLAYVALHCSAHRNIPLMDDKVTLMLLLHALNVPTSAYKISEKTVTLRRALCVKILARAFTYLTEVMGSVKLIQRWWFGYNVIRLKEKLARTVVRIQARVRERLFQEHVHTRAKARALSTDFIGLCVVLYHLKVSLLSSSQKTLQLLHSMEKRYHEKEYHHIQHAAAAYIQACWRGRVQRKRYDQMRVEQLEDFGAALVQSAIRRFLATAKLVQQKPTRDIAATAIQAAYRGYRARRQYEVLTGLKLALLSVVRKGSKLLSLGDHLKFVKERKRYNSTTMQMKKLIMMQTNLPPGFTKVQNMIRMYFVRKQYLHLRSAIEKVQALGMTKVARIKYLEKVKAATTIQRWWRGVRPPGVAPLSGNALYYLNMREYAAAAPLRELCNAVGMTLFHFRAYHDLRHVYPRSWAAEASGILDYLIQMQLTFIDTGNAECPRIVGLQFAVGAYHSLMLVSYTQGGSTALYSWGGAAVLEAETAPHPRTAGNRPGTGSTGGKPKRLHTQYLPKPLEFYTWDTTELVGLGRPQMVLVPRVEITSIACGNEFSLALDRSGRVYSWGTNVHGQCGQGHRLTYVWSPTMLPLREVTGAWCGEEHSVVRVSVGEYFVFGRAFGYAIYAPEDIKAHCQAIQRQRIVAVACGGTMTVLYTAELRYVLRVLGGSAAFAECYNLRGNIHSVCTNGRMICAVVDKVTEGGALGQQVLAWGHLRCFSKHFKEPLPNTALLVNAFCEMLEHPERRRPRRSLVKVDSHLAKSCSIAVPTPVNIAKRVLSVTCDHQQMLFTCLHGVVLGVQTFELIHDSPSDIRDSDGHGIRLSPQVTNARLEPALYQFAALEQSEAQVQLAYNRLSCSVGYVATPTPADQTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAL0</accession>
    <name>A0A061DAL0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769774.1">
        <property type="nucleotide sequence ID" value="XM_012914320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAL0"/>
    <dbReference type="GeneID" id="24566129"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400800"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="24733" checksum="F21CF00684BD2B67" modified="2014-09-03" version="1">MGGCVGRYQQRNLPRRDTTVGNDGEEDRLIKLIDEISKDRAKPTLNQYYDADFKAILKKYSRSLKETFNFSRNDAEILKVWKEKKRFDDVMIQFQPSLHSTLAYRQPDGSNSDDQSGVQSGNIPEIHVHVESNTLPEYLRKASNSLTYIPRNLKEAIDRLIDLKGIDHEQNVNANGSSKKTDANYHAPLSGRQNNTDETLVSRCFGKHYVYNVPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM5</accession>
    <name>A0A061DAM5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769223.1">
        <property type="nucleotide sequence ID" value="XM_012913769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565578"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309400"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1842"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1904" mass="214329" checksum="7541526F662EBC00" modified="2014-09-03" version="1">MLLTLHIPTQMLSPLIELRGIEHVELAFATHPIFQILVIVLTIDIQLHVTPQFKKLVDCPENLRESIDWLIQVRYGNGDSDGLDELAKALKKLIAEDIDKATNSLQSEKSKLECPVKYNDKLSNCAYIDKLMKHAKDSDNADQPKNGFTKQQITDMKKSCSDSHSRRYDDATKKALDGIKEREKQLEDLTNKLSIFTDKNHQKCTDLLTNLCTGLETFLGFNSETKGYTGHGIVYSDLDRLCDGVMAFFYGVLSNIKEHLGQHKNTLDDAIESLKQNKHRGKNGFNVAIESVVAGVRGYNESVRNSNNHVINKITDFDREMKRLKKSVSEIVQNNRVADETLKYEQVAEEMERRLAEYEKRAADFNKTLDMQNNDETTRNAINDLSDKLRDRIDNVHKTMVHEKTRLSELATKEKQRFKSMEACINTTLVGVGTCVNREIGNKVKELIRDLRQMVQKMFVQLEKINKELPQFVERLQEWIQKADGDVTKTEDNVKKILEQVNDGLTSNKIPIDDAIKELEKTKIALETYISGEKSGLTGFVNNVNEAIGRLYNKVTGEPGPVRNDKTIDEIMRHIKSKVMSIKGYVGVKNEHGDDTDESIYQNWDAIKKEILECVDLLTDTGNSSLTDVVKGINAFAGKFKKGEDYFGVIFKDWVTDIIRREPVKGWIDKYVEENKGYGYFNGKLSGRGTPALHAFVAPIVTRHITEKLQEIHPPNNFDATNTMDQKFLYILNYMNKLSTDLWNKESSIIRLMEGEVKLHSELVQSDRQTGHKKYYLELAVRATLASLASVAKHIGDQLDKLKTTSNIHNKLEQAIAQVRDLGSQLKSDKPGVKLDAALELLKEEIKNLHDNFEQVFQTSVDDDPNYAKAVDVAIKTVKSGIEAMNVDAIKDALSNWTHQIKANFAALTGEISVVSRGISEQLTQLKKYISLNNGGNGLQKIHDDLHNLIGPVADALKTAKRFLGSVDHSGTATIQALGRDVDSQVESAKKALIAKAREQYVTSLQGLLVSFSTKAEAELQPLPGLITKELDLGVKGFMNKIEKYFIGTDKGIKVIKDIKTTHSPPEKSPLSQAAQRAYNASRRFCHYLKSQTDFISDFQKYEPLHNAHLTLLDGLKSSEHFNHQFRDNLDTIKITLGQLAPQQFGTSSTVMLQALKGGIAALVDELDKTYVSSYSGRQWQDEERGHYAKIGLTITPILYQELTTFKHGLDIYDWTTHKIYDAQAPTSSLHALFFRDNGYDVRRPENAEHGELNHRNDFNGSSILKHLTNETHNLFSQLSSPVIGIRQSTSGSDELGVTIAEESGLIRKLYDCLNTYLKVCHLIRVDKPRAPCSVYEILVWCCGLQFNPVYERLKAQIKSEFMKEDKERPGTKTLQPFEAHPSPFQHTHIDEALYKVSSDSHAVLTAILGHGHKDGIYACDFSSNSLKLEYPANMIQLLCTLFDLLKRLYHQLYFLLQQCKHNAQLSGWRDCHYGKYIGGSGWQCNTKQCPKQDCDQRHDQSGNQMGGQYPNCGVKSPLQSFLEDGLKGHLPHSVAARGSSLSCGTCGSTPGMPCRTPMGFADISAIASHTMIGQDICDVLYDFCGRPNSPLTRLCSYLNCLLPSAPKTLADMFSFYYHLTDRWGMSGNGHKREAFEESVKAANFGRSYGELKVYYLFTPSHSALKKGHSDGSLGSLVCLSREAVVCGPYLRPISQSIYETFSSKHADKYLSWIVYLTATFYDLLKKLYDECNSKCGARGSNCHVKACVKGCPTTTIAQDPPRYHDRNCKSIVSCNATLPTLAKYGFVLGNPERLNGDRQSHTKRTCRDFCYVFAEAFEKDSHLVKFFKAIDNFMFAIRGPFLWMTVALWSLSLFYLICVMVGRLDVLHIRSHLRIPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM9</accession>
    <name>A0A061DAM9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766956.1">
        <property type="nucleotide sequence ID" value="XM_012911502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAM9"/>
    <dbReference type="GeneID" id="24563311"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110670"/>
    <dbReference type="OMA" id="IVHTYMS"/>
    <dbReference type="OrthoDB" id="364617at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596155" evidence="2">
        <location>
            <begin position="24"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="415" mass="44887" checksum="762888766670D874" modified="2014-09-03" version="1">MELKLLCVVNLLLLCLAPQFARSEAGREEPAAVIDEYEAVVTVAEDEPSRADEVDNEALTFDAGEYMRDLRDAAAGKAAMDPEKVYTAQAMLPLGEVLVLTTASGCSVLSDPEGEITGREEPLEFSFRLADLEDCGKVSESIISGLQAEVAAEWSSLSGNSADSGIASTTSLQDIAVRQGGKRSENPSSFGIGVQDLANAYVAANLAINLIPTTSEGIVVMHYDLTNTTTAEEITKAMSSVDPEKLKQLEDAFEMAKNTFNNATTEDLERMEEELKAFFEKENEKLQKDLEDGKHMLEELSSDRVAEIECSALALDDCKAVSKCGVVMINGKESCAVAPKTVYLLMETGCSLQSKAGLMSIARDLVSSGIMSEANHQTLRESFDLSRICNAIVHTYMSADIVETESHETKEAFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAQ5</accession>
    <name>A0A061DAQ5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0401250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769819.1">
        <property type="nucleotide sequence ID" value="XM_012914365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAQ5"/>
    <dbReference type="STRING" id="5866.A0A061DAQ5"/>
    <dbReference type="GeneID" id="24566174"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401250"/>
    <dbReference type="OMA" id="DRALMAC"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="89"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="280"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="472" mass="52396" checksum="8BD218F3EA8A441D" modified="2014-09-03" version="1">MGDIFAKLASYSGVRKSLSSQRVREKVSFDQELAIADSHGDAVEGATCLVTFDELRTLRENSDNLTWLIDSLHCRLKLSSPSPVQASVIPLALKGEDVFAVAPTGSGKTLAYLIPILLQHKKQKAIQSLVLVPTVELVNQVTRELVYLIGDNDVGILPLDPKCSQLDKEICISTPATMLSVLKKRKDVLSKLELLVVDEADVLFDGGYARHFDSILASLVEVRGLRKMLFSSTMQQQVLDLAASFMPSAVHVSVGQSTMACKNVRQELICVTNENGKVPALRQLIREGRVDLPCLVFLQSVERVGRVYSQLKDDNLLVDRLTGRLAPAEREELINKFRLSKIWVLLCTNILARGLDFRGIGSVVNFDIPLTAQDYVNRIGRSGRGETSGSAITLFTMDDVNIMGPVIDIMRRCNQEVPEYLLRCEQKKANVKRPPNRQSDVSQRKRHKHRCAKVNGKNVANSNGKQVIKQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAQ8</accession>
    <name>A0A061DAQ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome oxidase biogenesis protein 1-1 (OXA1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0211440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768185.1">
        <property type="nucleotide sequence ID" value="XM_012912731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAQ8"/>
    <dbReference type="STRING" id="5866.A0A061DAQ8"/>
    <dbReference type="GeneID" id="24564540"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211440"/>
    <dbReference type="OMA" id="LNCTKIM"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="379" mass="43062" checksum="61270D0CC14C0C9D" modified="2014-09-03" version="1">MYTLELFRAISARTSNLRDVQRRFASTLCRERRIAADYAWPRRRFDARLMSTSKNTHSDNDITAEQLPNSRTESAISSDGGDPVGADCGNDDIFDLVEQHNGTSKGLIQRILPVEWMRDMVVAMHDATGLSWAATITSLTVLFKVGFVPLWAMGERARRKNAHLMPIAAELQEQIRHAQKTGNVKLAMEVQRKLYKQMTRKTFLKGAALQVLAAGTQGLTFAWVYGGLKMFAIEPRHCTGFVLEHPFWLNSLALPDPYYVFPVALWFLMTLVYELNRKTAERMRMSAGAVSEAVREQEQRQTKLKYFTRIAIGVFAYFSCSMTSGTFFYLIPSFLFQTVLRYLSQSVFVAKALRLPIPAPPPVQKPETKQLLRVKGFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBA4</accession>
    <name>A0A061DBA4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial processing peptidase beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0402810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769979.1">
        <property type="nucleotide sequence ID" value="XM_012914525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBA4"/>
    <dbReference type="STRING" id="5866.A0A061DBA4"/>
    <dbReference type="MEROPS" id="M16.975"/>
    <dbReference type="GeneID" id="24566334"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402810"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000008">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="82"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="234"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="507" mass="57106" checksum="48CFB2EBC2FE8E68" modified="2014-09-03" version="1">MTMSTMRGFAAAMVRQAYPGLGGVEAGKHATRKAIRNCALSGIRGARTISTATELLKDSKIISQFLNQAPCEVTTLKNGLRVASVWMPGNSSTVGVWIDSGSRFETPETNGAAHFLEHMIFKGTSNRTRLQLEEEIEQKGAHLNAYTAREQTGYYARCFNKDVPWCTELLSDILQNSRIEQNQMELEKHVILREMEEVEKSTEEVIFDRLHMTAFRDSPLGFTILGPIENIKNMKREYLVDYIQRNYTADRMVFCYVGSEEHDKIVQLAEKHLCTIPSGHGERHLEKPQFVGSELLNRNDSMGPHAYLAVAFEGVSWTNPDSICFMLMQSIIGSYKKSQEGIVPGKVSGNKTVHAVANRMTVGCAEAFSAFNTCYKDTGLFGFYAQCDEVAVDHCVGELMFGITALSYSVTDEEVERAKRQLVLQFLAMNDSTSTVAEEVARQLIVYGRRMPIAEFLIRLEKIDAEEVKRVAWKYLHDQEVAVTAMGPLHGMPSLIDIRQKTYWLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBA5</accession>
    <name>A0A061DBA5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S27, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0311600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769443.1">
        <property type="nucleotide sequence ID" value="XM_012913989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBA5"/>
    <dbReference type="STRING" id="5866.A0A061DBA5"/>
    <dbReference type="GeneID" id="24565798"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311600"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9173" checksum="763A20D1808376BC" modified="2014-09-03" version="1">MEFDCLHVDPKEEAKKHKLKRLVQNPNSFFMDVRCPGCLTITTVFSHAQTAVICGSCNVVLSEPTGGKCRLTKGCSFRRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB9</accession>
    <name>A0A061DBB9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="5 19">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BBBOND_0201970</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 19">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Apicoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="5 19"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767226.1">
        <property type="nucleotide sequence ID" value="XM_012911772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB9"/>
    <dbReference type="STRING" id="5866.A0A061DBB9"/>
    <dbReference type="GeneID" id="24563581"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201970"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020011">
        <property type="term" value="C:apicoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0933">Apicoplast</keyword>
    <keyword evidence="7 19 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 19" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="22">
        <location>
            <begin position="12"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="493"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="20">
        <location>
            <begin position="753"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="1166"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDR95040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1271" mass="142854" checksum="00B41DF62080E3AA" modified="2014-09-03" version="1">MTEFNVNRVSAAHSHVDSFNAFIDHYSKHVVKRIPPVYVSADADYLKYLFNTSEKPHFKFSIDVQISVLSLRIDYPTRPSSECLGSDTRMFPRHAKSAHTTYEAPLVVKFGLKVPGIDGVLTKEIVVGFLPIMVKSKRCNLDGLSPEGMVQQGEDVDETGGYFVIRGNERILRQLIVLRSNYPLAIKSENNRNKHALFTDYSIMMRSQCCDDGCSVSNILYLTVNKRCVFRTIVKSSVVLIPFGLLLRATMPFMSDEELKRRLLEDALGDVELTVYYHRFFLDMTERDLLLSDIDFKENRYLYRLGSACWTQIQQYMPPGATYEECGAYLLRNYVLLQAKTNSEKFDTLMYMFKKLIKVSRGETQTENYDSFAFQELLLPGQIYSCILKESLYVALLKIRSIYQAELIELCKNISGGAARRSKRQVVEMELGSHDPKQLMRQLLERAELFSYAVDKVAPDITKKLHYFLATGNATTTHFELPQSSGLTVVAERINYHRSVHRGSIFAKMRSTEVRKLLGETWGFICPVHTPDGAPCGLLLHLTQYAIPVTDADCGSATDAVKSFLRHQGYHVDFTGNEAVSQFWQSGTNDSGRIPVLVDGIPVCNVPMADAHRLYCEIKRAKRNEIFGLKQHYELVALPDCKGQYTSLMVLTYPGRVIRPVRCVKTGIIEWIGPIAQLWSTIAVNEEELKLSHKILDESKSRKSSKALSTSEAIEKYKAGSISEPKEGSTLDNVPVKYEYVEVSPTAILSVTAALTPFSNHNQSPRNMYQCQMLKQSMGVPYHCEQFRSDVKAYRLLFPQKPLVTTEEYRRMKYEDYPTGMNAIVAVIAHTGFDMEDAMIINKSSLERGAFHGCIYKTKVIDSMPPNAKMREGQYYFNNTNHLGSKIIPSLDKDGLPSVGSRVRNGTIICRVEARERIDGGHHTTDRVEKYHDEDAVVDQVTMIGASDANAADRAGASGLKCNRATIKFRIVRNPIVGDKFASRHGQKGILSMAWPAEDMPFLESGITPDIIFNPHGLPSRMTIGKLIECMAGKSAALHGEFQDATCFRTYPKQMKTGNKWIDHGGLKGWEERGGRYMTEEEEAAQTEDDVVDYFGKTLLQAGYDYYGTESMYCGTLGTEIKTHIFVGCIFYQRLRHMVSDKAQVRSTGPVDAITKQPVKGRKNRGGIRFGEMERDSLIAHGASALLQDRLMHCSDAHTAYVCPKCGSILSASITSIGLTSKVQVSKCRLCDVKCKLVTIPYVLRYVANELASINVGIKLHLSQLGVPIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBD8</accession>
    <name>A0A061DBD8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770029.1">
        <property type="nucleotide sequence ID" value="XM_012914575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBD8"/>
    <dbReference type="STRING" id="5866.A0A061DBD8"/>
    <dbReference type="GeneID" id="24566384"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403310"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="10049" checksum="4890E229774D2F4C" modified="2014-09-03" version="1">MVSEYFEYPPQWKQHDGVLYQRYGDPKPSSKLAMFDMDNTLMLTPSTLVPDLVKGCKPWINKPAIPNDFILYNTNVKQKLQQELADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR7</accession>
    <name>A0A061DBR7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767381.1">
        <property type="nucleotide sequence ID" value="XM_012911927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR7"/>
    <dbReference type="STRING" id="5866.A0A061DBR7"/>
    <dbReference type="GeneID" id="24563736"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203520"/>
    <dbReference type="OMA" id="YEVRSAN"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="76"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="554" mass="62969" checksum="E74A4A4881F9B17B" modified="2014-09-03" version="1">MDGSCEDTYDITYDEDCYCGVTSDDFDAILRRSKRADDGAVGSSDSEASSSGGDDSERSIDAAMQRLAASVTAMQVGIENMRRVVWGYFLGVYTADTMEELLAAVRQKRERYWELVKKHRQDNLKSMQALNPQLFHPLAPVERNPWEQNQRSRELLDEIWQDVERTYQERSLFKSESVRKTLQNVLFVWSREHDYISYRQGMNELLAVVYIVCYRDQARPADSTADSAFAEICSGDAKDLEADAYTLFDALMCLEIQLMFDNAATKMPSIKSYEVRSANLAHIVALPGRAKANNTHNSFIARTKFIHSRILKDYDPALFKHFQDIELEPHVFLMRWIRLIFSREFNVNETLCLWDAVFADHHATTLEGQRLPEFQFELVDFFAVAMMSYVRLNLLENDINYCLQRLFKFPPIENISLLIAKAHKIRRQFNKLDSGKSAVANADSAARASGSIPWVPVDDGSHVSLDKTMRARTPRAASRTSHEAGRTPYMSLERMDSNASAFASPSESGLSVSTEGLRHALEGVAARIYRLYEEAFAVGRWDCVCLLSFSAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBV5</accession>
    <name>A0A061DBV5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769643.1">
        <property type="nucleotide sequence ID" value="XM_012914189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565998"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313590"/>
    <dbReference type="OMA" id="DADMFAY"/>
    <dbReference type="OrthoDB" id="364591at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1661" mass="187020" checksum="81E84B1365D4D330" modified="2014-09-03" version="1">MATVHVAKRRCTQSSRKKLLQATKEVCQKRLSELTDDELGGYLQTLGWPKTLAPAVEAYEAQGSFIIWLLNRMLTQLKKWMTLQASGKLGTGNNAEQSDGAYGDAGEGGSAKIGIPSIFRPMETKLVAYLVSHTSNINALYAHSHVLLKMAMFHNTWGQVPMDELALRDFENPYLKLIEAPNAEEALARYKEALEAVNDLLRATYYHIPPQDDVARTNNRIHMSSNLNDVADRILDDVNMFVRWNHAFQSFKPATANKKVVKLVAQITCALAEHLGILSEIMRELMEASSNAKHAYHCAAQTLMAHVLLVCAEMDDFKIQAKLLFRRTANAAKDSTGDKFDQRINTARRRLTRMLTFTLTSKFIPGLKEMLKSKEYEDLFDMEQLGNMDLEDSAVTYNRRFLLNIVSTIHRAEGQEEALQQARGLCIVLVELLSIAIEGISSQTPEAQDPTYYGVMMFAVILPLIMRLVEAVVGKVEKQPESYVPYAAVVDVARAFYEALNLANNKQILVYSGERAELVAKINSQATVFVLKTLESCYGSIENNRKRKALMDSVQSDENVMKLLIKKAHAEQHENANATAVAQIMPIMWDALLLLVSLSLEHADENIRQILKLLNQDYAFHNSSYEEHAFKILIKPQLSLSNVDSHRKSHVFAANLISMYSHANDMAALLDHMGEFVEQIEQPGAACPFMLHPPAMQAFNNSSKESSSLQIPIIIKQFAEWLKKDRVRHFMQYPLMAYLRGIELSATLVMRTADAFEELIRIAPVKHDPEGVLMAVQFIIIIRKIVSWSTMDDSTNRWDTYLNNIYVYVGQLAEAAGKNCSIAIWTAMFWFAYHFTLIIRDQPHVYGHMQHGINRVIRRLRKIARANSDDQSFVEDANALIVANANVFDNEDEYNALIKTVCNALMCFKKDARVLDNLKGTLDVLATGQKLINEIADINFLTNLVEILTGADSGVDLKIGAARMLMQVLQYSPPLFQHEAFEQLFYALPVAAQQAVVSAGVRQEDVMEFVKELLATVNFILRREEQLGGRRCSILTLSDYLSILDTSAGNSELTDCGVRHSKGVMHALCSVKQALNLNTSVQLRLSLAILQQIASVHTFIMAKIADEGFMDIVGLKTGGCDVQTLIERVLNVVVPAMMGASEKREPDAANDATTVSREDVRSDELVDSVLLAYINKTWRSEKGAIGNAKITRIQYHRQLSDILHDVGNALEADSSTNEVHILYLASVLYSVASSAQDNEHGAALEQVANIRNKAKSIHHIAPDVIEAMYEAVLEVLYRCVPTTTETQIHSHAVHALTLTAYMQHAICFKRQRALGFGGTQLEIYKALSGCQVDKVAEIVQAIHDHADPKQLWIAFTKQLERVTQEADEQPAPYDWRYRAAMLEVMVMFADKSHLKALYSLKGAGRKKILATCNVLLCLNAKQIENVDPMLAAQEDTETMHWVVLNYLLNTAVSIKLFVFTRFQVNKQMQETQATIAQHLLELARLGIDLLKKCKQHGLSRELFEQIATNVYLALYNCIRIAEGMSNAQIAKLVRPWVRRVHVVTYIITRFVELMETHDADMFAYVARWMSIISNEQLVDATKWYIPHMVTAIVKAWHRVSKDLSTNKTRREDVLRSNKILRSCIIETMGACDDNAVKTLFLLLSQDLRLFVKESTRIFNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBX0</accession>
    <name>A0A061DBX0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sf-assemblin/beta giardin family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0204080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF-assemblin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767436.1">
        <property type="nucleotide sequence ID" value="XM_012911982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBX0"/>
    <dbReference type="GeneID" id="24563791"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204080"/>
    <dbReference type="OMA" id="QNYCDEQ"/>
    <dbReference type="OrthoDB" id="436841at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008374">
        <property type="entry name" value="SF_assemblin/giardin_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40412">
        <property type="entry name" value="SF-ASSEMBLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40412:SF1">
        <property type="entry name" value="SF-ASSEMBLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06705">
        <property type="entry name" value="SF-assemblin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01799">
        <property type="entry name" value="SFASSEMBLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="344" mass="38829" checksum="FC317BD3E7CE6EEC" modified="2014-09-03" version="1">MSDSDLLISHSSHGSLPDSAYAGMGDLGEVGRTTVLRNTSKYNPTITMSTGDTVLDSNHVFRQSSHPVGSDGFSGRELFLVHDVLPETEANDRRFQGGTKSKLMILSEKLQGFERQMEFHAKQRRMHEEQRFLNISEMLNKLDEAISQESKRRMETIKALHGIFESQIGAVQTKVETFFNDKLDQLEGVVSSLSERIDAISARCEDNEKLLQDNLENNCVALEKNLATVQKLFESERLSRQEREEHILKRISDVELQSESAFGKEMQNTENQYHQLKSEFDKIKQQNEEREKMIKSSVLDEIAALSNGLAVESCARESADSDLTQALHSFMKVIADVSKLPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC85</accession>
    <name>A0A061DC85_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0304720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768755.1">
        <property type="nucleotide sequence ID" value="XM_012913301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC85"/>
    <dbReference type="STRING" id="5866.A0A061DC85"/>
    <dbReference type="GeneID" id="24565110"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304720"/>
    <dbReference type="OMA" id="KNEHGIT"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="11">
        <location>
            <begin position="345"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="447"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="487" mass="55234" checksum="E3FC06ED354ADE83" modified="2014-09-03" version="1">MAAANAVLVFGSIRQSGGSDTGAFKVSTELFGWKNKRTGEVVQHRQNDVQNITLINTGGGTYQVRFEMNAAKDNAVLRFCGFSEKGIAELRQHLETHFKVPITMDEVAHTGWHWGTYEFDSNTFKLKIDEKTAIDIDAKSVSQVTVPAKTDLAVEIKPEKASTTGDELVEIRFFMPNKPDSEDNELQLEDLKQTFLLKAGLDELKTETVALLTDVPLIVPRGRFEIEFTRRHIKLHGKSYDYNMFFTNISRMFLVPKPNSPHVNFIVGLHQAMRHGQTRYPYVVMQFDAEEDIELEINMPPADLQTMKLEKLMTGKTFNVVTKLFGTLVSKPIVVPGEFKSDKGESGFSCTYKATSGHLFPLNRSLLFIVKPVIFIRFDDIISVEFSRTGMSTQNRFFAFSIATKLGQEFEFTNIDRAEFEPLSKYLASRDVKIKRLEEAEKAANYRAAQLAGAEDDEDDEEDEDFEDEEESDDDGSDELEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCB6</accession>
    <name>A0A061DCB6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768805.1">
        <property type="nucleotide sequence ID" value="XM_012913351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCB6"/>
    <dbReference type="GeneID" id="24565160"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305220"/>
    <dbReference type="OMA" id="RICHTIY"/>
    <dbReference type="OrthoDB" id="361487at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1062" mass="116931" checksum="C0D83D17E1F14181" modified="2014-09-03" version="1">MSSALRKELLDALRARFAPLIRDADLSNCNAAFCGGTRVYRTVQLYRFFDLSRVDVSSEGGVKRQLDSDFVESIKLLEVTPPDDLRLFEIYPLLRRIMILIEGFLGHVSASQRFEGSLAHGRGLSLPDPSLYLVLDELYDKVSGNSINRDRLLTGLATLVAAGGGGLDSVLLSASTFANLMVPVIANSFDKYGGDILESALATLTFGALQRLSALFLLMVVVDQSAGSASARSRGRGEPLLSLSGDEASNDNMFRLQFLCNETLLKPLVTKVTDHHLAVCWNEDIVSPVLSMLQYTFVACGKVVARSEPLADLVIATTKGVLMKVPEDCSPSRATLDLILGFGHQLLGMFYQGLELVNVALWYHFESRLSHVLKLQQQQAPMNKNGSPTVTPADLHAQMAAGAINGSMRLPSSADNSPYRPLGRSLNTLLSEGELKSTLLAFLASLDYYSRHQDDLFDVLFGNYTRKADVELLDCLSRLFVHYTCLVQLGDAVAYITQRSPNAEVGDLVKQAISMLWSTLCSLGSRVSFNALRACFYYLGSSLHSCNVAAQICCFNAISHSQADIRQWLNLPRDTYVFQVEMLRALLRNASSACCTCISYGASKTRRFGGQYLSIPSSFVSRWFIAEIVNYDVSENRGLVDAFVEWCNSARPEEYMLCRFLCRVLARLCAEDNAVIDGGRYILDVLLGICMHRDSASVGLKSVMQPLSRGRLNAFKCLGVLLSTGVFTDWVLRHVLLPCTCAFTQQVGEYVSQFLGSSDPADRVSSGCYFASQGSVCKCLDAPIVSHSVGLLQYLELVSSLPLDKRDPNGKDEASRIVPHVFGVLCGLLRKLAALLNTHQDRADVNSRYALFVLSARLTGVLVRSGQFGRKDAEVIALLKLYALLGNPRICVVEEVDLYLSLILEALCTFHAIFDHVPVKEQLLKLHRGFLALLLSKIEVHPKFLLRHELYSGVPRPMFDQLCGSFANMLRMASSMGHYLGALYSFRIWSVLRRYGVDCADVKKEYAEQALNDQDVPAEARITFNTAFMVSCRTPAITSAAVPCSVRALVEQGSAIGLYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC0</accession>
    <name>A0A061DCC0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767646.1">
        <property type="nucleotide sequence ID" value="XM_012912192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC0"/>
    <dbReference type="GeneID" id="24564001"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206180"/>
    <dbReference type="OrthoDB" id="10308289at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="6972" checksum="A5EA836FE0AF04C5" modified="2014-09-03" version="1">MVLPILQYFIAAVKLTLALSPLLVIVAIFAVNKNCNQRSSEGSRSGARIEYIDSSDDDTKNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF7</accession>
    <name>A0A061DCF7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767716.1">
        <property type="nucleotide sequence ID" value="XM_012912262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF7"/>
    <dbReference type="STRING" id="5866.A0A061DCF7"/>
    <dbReference type="GeneID" id="24564071"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206880"/>
    <dbReference type="OMA" id="FNTHREQ"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="170" mass="18194" checksum="B3A6F6470D200488" modified="2014-09-03" version="1">MFATTSEESHEDRIKAAFRAKAKMFLYTIAITKIIGLAVQYLSANEDKEQHFCSVACYKQHSCSGLQSNAAGGASPTASTPAALGTGGKEADLSEPQITALKEDQKLRSMLSNNVLRRVLRQIAASSDPASAIAPYMRDEFFAGFVTQVLETLDAVHEPAADGPSALDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCG2</accession>
    <name>A0A061DCG2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thiol oxidase</fullName>
            <ecNumber evidence="2">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0206980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767726.1">
        <property type="nucleotide sequence ID" value="XM_012912272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCG2"/>
    <dbReference type="STRING" id="5866.A0A061DCG2"/>
    <dbReference type="GeneID" id="24564081"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206980"/>
    <dbReference type="OMA" id="MAENSCR"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="157" mass="18575" checksum="F35F1307E5056FC5" modified="2014-09-03" version="1">MCSRESTNLPERRRYTFAESLAAVDRNAAVDPCSAQWILIWMYGAYVDEVPSDSQRRNIDVFYRTLTDMCKNGQQCFQRFVTEFPPRTDSRRALLGWVQMAENSCRIQNKMTPRIFKYVVIVPRLQLLQLRRVDEALAVPRWLHMIRLLRYRSPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCH7</accession>
    <name>A0A061DCH7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768905.1">
        <property type="nucleotide sequence ID" value="XM_012913451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCH7"/>
    <dbReference type="STRING" id="5866.A0A061DCH7"/>
    <dbReference type="GeneID" id="24565260"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306230"/>
    <dbReference type="OMA" id="MYRRYIW"/>
    <dbReference type="OrthoDB" id="409554at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21816" checksum="1AC0973DB4F1CF7D" modified="2014-09-03" version="1">MSHCGLLTAARRSLRYRLGRIYNSFYYSQSNNKYVMLFVFPSVIWYTRFRADTRLGYRLYIAPTAGGPVDYLDQIESGSVQKQTSEPDETHSSVLLDALNYVDDTIMGVWRWIKGSKPLIEGFKNGKKIYLDDSATVADLKKAIYGRKALEHEDVLVGCKGRVMQTDDNLALATRAFCRRDPRIVLWRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCI0</accession>
    <name>A0A061DCI0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767766.1">
        <property type="nucleotide sequence ID" value="XM_012912312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCI0"/>
    <dbReference type="STRING" id="5866.A0A061DCI0"/>
    <dbReference type="GeneID" id="24564121"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207350"/>
    <dbReference type="OMA" id="KARIYES"/>
    <dbReference type="OrthoDB" id="366276at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="178" mass="19555" checksum="43C3784FF86A1D88" modified="2014-09-03" version="1">MSYGWLSESTLAPRKARSLQVPKGSVSVLKRIISKHTSNSSAAAPAAKPRRKKVCQPRCLNIAAQDPFAEKNPGVELRNQVDRVGQSTSSARVRERLEAKARIYESLAEGRESEVPEGLEVLVNFQTKRQLDSASCTVLNEEGVVVLQKAPEVPVVPDSDRVVNEESLDTVRAFSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL3</accession>
    <name>A0A061DCL3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)</fullName>
            <ecNumber evidence="3">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0306780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768960.1">
        <property type="nucleotide sequence ID" value="XM_012913506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCL3"/>
    <dbReference type="STRING" id="5866.A0A061DCL3"/>
    <dbReference type="GeneID" id="24565315"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306780"/>
    <dbReference type="OMA" id="TGWHDVP"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000003">
        <property type="entry name" value="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="28390" checksum="2EAB38DEDD4942AA" modified="2014-09-03" version="1">MYTVVFVRHGESEWNLANRFCGWADKALTETGKNEARECGKILKEANYKFGTLFTSVLKRAIVTAEIIMEVLGQSEIPTFRNWRLNERHYGALQGLNKAETVEKFTLDKVNIWRRSYNTPPPSCALDSEFYPGNDPMYADIPRDEIPNGESLEMCQKRVLPYWNETIIPQMKAGEPVLVVAHGNTIRALMKVIENITDEEITKINIPHGVPIVYNFSCDMKLVDKKFLMSEEELKAKMAEIANQVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCP1</accession>
    <name>A0A061DCP1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768980.1">
        <property type="nucleotide sequence ID" value="XM_012913526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCP1"/>
    <dbReference type="GeneID" id="24565335"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306980"/>
    <dbReference type="OMA" id="MNQSEMN"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="596" mass="67107" checksum="4AC22D160A9C00A7" modified="2014-09-03" version="1">MALNGLAQKAAMRSCYDYNRRYIGILRSHGLPAGGCTAARLSVSTCRRGLCSNSLPQLHCLKFAAAEAIAARRARMARCFGALRTDSTPQEPASRQEAHVSSQHSQAQSDIVKNEAEANIVLRKPIPKNFIRETFLPHLEHNVAYNAHKFPPAVVLQIAIAYSKLPAFIRQRAIEDSLVETFIDRMVDYSAADCVQLLNTSLQLQGLRNLKVFREILKRLQDKHVFGSITVINRLGLVRNISRIVQRAHVLQGDTASVPLEVDMLDLGKYQASILKPWTLITSTLRCKELRKLCSDLVDFGGDALLPQLEYEMQTFDSNELCDLLGVFAERAERDSAKLDFPVIAILMQRIIELNDQTPLSNKLANVCSLCRLGVSHEGYLTMVAEEMRNPLKVNNIYHRHLARVLWAFSRFGMLNRVLESLMPHLERNSLHFEPSSIARLSQVYRGEAEAGEAPAELLGKLRDVVVRNVLHSLGQLNKMAPKQLLFFYTAVCYLHMLPEPLDYAACVAAKATGLPRYSESAPQPYDALLRAKDKTRSHILEAVLAAMEQLESDFDLSEIQRVVSLTMSLKHAHFVLDHLPRSWSRIVKEHEDEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR4</accession>
    <name>A0A061DCR4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aminopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0208790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767911.1">
        <property type="nucleotide sequence ID" value="XM_012912457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR4"/>
    <dbReference type="STRING" id="5866.A0A061DCR4"/>
    <dbReference type="MEROPS" id="M01.005"/>
    <dbReference type="GeneID" id="24564266"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208790"/>
    <dbReference type="OMA" id="FKRWYSQ"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09600">
        <property type="entry name" value="M1_APN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000002">
        <property type="entry name" value="Putative aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.10">
        <property type="entry name" value="Peptidase M1, alanyl aminopeptidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038438">
        <property type="entry name" value="PepN_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012779">
        <property type="entry name" value="Peptidase_M1_pepN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024601">
        <property type="entry name" value="Peptidase_M1_pepN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037144">
        <property type="entry name" value="Peptidase_M1_pepN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035414">
        <property type="entry name" value="Peptidase_M1_pepN_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02414">
        <property type="entry name" value="pepN_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322:SF1">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11940">
        <property type="entry name" value="DUF3458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17432">
        <property type="entry name" value="DUF3458_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="12">
        <location>
            <begin position="41"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="263"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 alanyl aminopeptidase Ig-like fold" evidence="10">
        <location>
            <begin position="482"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 alanyl aminopeptidase C-terminal" evidence="11">
        <location>
            <begin position="579"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="902" mass="102068" checksum="CB18ECEB31D3665C" modified="2014-09-03" version="1">MASTSATSTVTETATAVQGVQSLSLKAPKEHVEIFRKDYKPTIYDIDSVFLDFDLHETATVVKAELLMHRKEGTAPADLVLHGEDLDCKKVSVDGHELEKRAISGYSIDDDGNLTIPVSFLPSEAGKAFKVNTEVVINPEANLQLSGLYKNSLLFTTQCESHGFRRITFFLDRPDVLSSFRVRMQADKEKYPVLLSNGNKVASGVDGAKHYAEFVDPYRKPSYLFALVAGNLKSISGTFRTMSGRDVLVEVSSEPEDSTKLQWAFESVLKAMKWDEEAYGREYDLDEFHVVCTRAFNFGAMENKGLNIFNSSLLLADVNTTTDSEFITIMSVVGHEYFHNWTGNRVTCRDWFQLTLKEGLTVFRESEFAGDMSSHLLTRITDVRNLITYQFTEDAGPMAHPIRPESYISMDNFYTTTVYDKGAEVIGMYKTLLGKEGFRKGMDLYFQRHDLQAVTCDDFRAAMADANGVDLTQFERWYYQAGTPQVEVLEAVREGDEFRLRLKQHTAPTPRQEMKLPFHIPIKLGLVGKTSKKDLKGTVVVELREDEETFTFSGIDEDCVLSFNRGFSAPIKVKYEQSDEDLLFLMAHDTDGLNRWEAGQRMRTKVILANIEQASAINESIFESIKTILASDLDNNEKALCIMLPDIQALVAELETYDPYKLWEATRRVRRSILEKCEPEFMRHYESLRSEVDTLEKDDMARRYLRNTLLGYLVCRGDAAAVELALNHYRAARTMTDRYSAFIQLMNMDFAGKDAIVADFYERANGFALVIDKWFTAQAISDAADCLERVKALAAHKEFTNTNPNRANSLVRAFTRSVRFHDPSGAGYKFLADQILGVDSINAHVSSHQAIHLTKFKKLDAARRSLMIAQLQRIINTASISKNLYEVVQKSLDYAKEQGFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD24</accession>
    <name>A0A061DD24_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768071.1">
        <property type="nucleotide sequence ID" value="XM_012912617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD24"/>
    <dbReference type="GeneID" id="24564426"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210380"/>
    <dbReference type="OrthoDB" id="366152at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="354" mass="39450" checksum="4A0561AF1D68557E" modified="2014-09-03" version="1">MDVSYETGACRVNNLNDSAPRDPYALQSSVTYPTEAPVEDSEPASAPQCNSVIVAGGTIDGYLYIWRFDWDVMCRTAGAKDDFSPFFSQMIPIFVDPQDDEPSHRIVSLHFLPSPQSYLLAIALYMGTVVTWDIRNGTLEGEINAYYTVNRPVTIARWTENKQFIIIGGPSVMCVEWASKVGMTALSYDRVSRVACSGSCDNICWSVDSSANFVYLVYDDGLFVQAPVVALTKRNVQDVVTSYLWEPFVKEDEPVASVADVDTQDPMAAAQELAELQFKMDMNSIRTHGVCVTRNGSRFRGARKGKVESDRVIRNKVYSHHCVKARSVLFSEFRLSFMAYGGHTGLLHVIIKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD52</accession>
    <name>A0A061DD52_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diacylglycerol kinase</fullName>
            <shortName evidence="6">DAG kinase</shortName>
            <ecNumber evidence="6">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0310070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769290.1">
        <property type="nucleotide sequence ID" value="XM_012913836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD52"/>
    <dbReference type="STRING" id="5866.A0A061DD52"/>
    <dbReference type="GeneID" id="24565645"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310070"/>
    <dbReference type="OMA" id="TRVEMYQ"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012430">
        <property type="entry name" value="TMEM43_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF121">
        <property type="entry name" value="DIACYLGLYCEROL KINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07787">
        <property type="entry name" value="TMEM43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012429675" description="Diacylglycerol kinase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="9">
        <location>
            <begin position="410"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="802" mass="90567" checksum="11EC8D9E27D7A9B8" modified="2014-09-03" version="1">MLVILLLLASALVLGVTLLSDVRLCRNRCQVLPLLSEVVEAPCVPSDKFEHRLVYIDCEIDTRHTFYAPKEFSSNIYSYTGAFFDTRVEMYQWVDKVGYYGVHKVGAFVDHAVTQKNFVETLFSTERNPGYIPHVPGFGRKFAPKLKLGGYSVPPGAFAAVRGVRQLPLIDDRWYQPSEITYPLPVPNVDYLNTQVHNNALYTGDPQNPKIGDLRVTFWGNDTMRFSAIGRQRTALIPKETFLEPFPLLDDSVVLVGEGGGSPLDLATAYYSQFESTQATYWSLRLASLVLITATLYLYYYGLRAPKVGEIWHYPQCAKSRVTLLLCSFCASSATLCMLEAVIWMRYRFYLFFLLFLLGCGFCGAVMSIWKMDPCSGWDPTHDSGYLGVLGRYDSRRWSTASPTASVALSSDRPLLPSLNISGGRKASNFFEPEVDELRFSKPVPAIVRIYSITDGVSGNKPGLRHLRDFMASKSPEDNVKVVICGGDGSVVWLIGEMDAHSIDYSTITFAIVPYGTGNDLARAVNWNDFNGLMPFDMNMTPLRRVLERMYKAEEIQHDLWQILITVEPEGSFNKISSSTHQKQTILDAEGHEVLHMEFVMGNYFSLGVDARIGRGFDRLRSNSGPMNKLIYLMQGMKNTFRPVVRVDKQIDKMLCGEGYTKTVFTTDTHNLEFPILPRTASLVALNIPSYSAGVAAFTKARRIGLENLREDEIRELKKTSQKMGDSRMEFVTYRRITHIAADFCGLGVARRLHFGAGPWKILFKELPPREKVYFQVDGEFFVMLQPKDVEIKHFKTIKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD57</accession>
    <name>A0A061DD57_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0211170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768156.1">
        <property type="nucleotide sequence ID" value="XM_012912702.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DD57"/>
    <dbReference type="GeneID" id="24564511"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211170"/>
    <dbReference type="OMA" id="IDHFVQG"/>
    <dbReference type="OrthoDB" id="383349at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="3417"/>
            <end position="3437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="3449"/>
            <end position="3468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="3500"/>
            <end position="3517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="3538"/>
            <end position="3561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="3627" mass="406937" checksum="F57BD62AC6487A9A" modified="2014-09-03" version="1">MIHKLIEQMVKAFGRDVIEQWLPLDRLNITSITDPEIRLTNVPIPEKCFEHPSMPFTVVKSNIRSVIIRCPWNVMLQKDCNAALSIEVRDVEAVVRFKRIDEWGVDIVQNALTSTRERLLRKWNAVASSLRLLSVKKGKRGSRAAAILNSLDIAVHNVRVVLLDNLLYKEAFAITIEAEFIRGVGMQQDDPSLSEDERKAVADSLLNALWFNSPKVHVWLTVYNQGQDATFIQQDLDVQDDIFDPQDWGGRCSQQQSSEPAKPVATNSRRTCHPEDETPGSASSHSSDELFGAAHPETSPSTPVEDGQTRLWNFCNAPCGDFSADYEGEYVEQRIKPEDEPLLRVINGPYQNFNVTPPEGVNFDLVFKMWNIMSLSANPDARRQSRRNVQICVSAPGGEPRVHAPCFDGETPFEPLDLTLTCTAADIIYNVVRYMQLNSAYREMASGGINAVPSVADCQRFIEVTRTSQWKHREEDAEFVKRFERDVPFHILLKVKEMAKCNQAMNVQQDSCFVSVPCCTAQQEDEAEEFSEEGGMPSHDWYEHESLLRMVFPNVNVYLAAIDVSQTAECVPSTIVQLSTFVFQTAALYKRATYKILACKPIVRCGVMLVNVRRRTFSAKVTMRPQKDSESLLCYPEEMLVEPHTFFEHYGSDDVESCFVRAEEGTRDTLCVTIERYPNHIKHARVVAPKLVLIFNTLLRLNALITERFWQMQFLTFEAFVRRNSKLGHENTELVEKMANHLEISTSRTICKVEMEGFIVRTLVQKEAQLKYAAGADVEGTDQPDATQRQMDVLDLFLQNDNMLDKWDYCDDIDNPFSMRHAASSLNEHGSMSQLDGSQKIIYSKDKFLAELETTEPIYSSRQLYMLAPESNAMFPLSSSLVFHLAELRRWYHNTCCVKMPPELVERFGTLRSLSLDARKLVFSKESVSTLTCCTLDTAILNHVDHDGATTRLFTLDSLLVVKKENAICADVGNVVATLDPILPILSMLVSHIQLFKFYSDAIQSLVGVLKVIVEAKQKYVVRPMKLTGNSDICRIISNDFYKGSPNVLEGCNADLVNAIEKKLSDVVGDAKIVFLSFNSLKLNLVGESRLYTFSIYKVRLEVKGRERFKFYVGNVSVYRDMGGSRQVILSSKPLELGQEVPDAAKEVHYGQVVVDFKQSDVSNVSMEVRDVHHIVDIPLVRRLVQIAESLKKAAQRSEQKEHKNIVASIMVHHSSVNHAGVGAMIDVYLVANVSQLETMKHLVIEIPRFHVTLTNGYVKRILAVSLLDVSFDMELYRRMQKTKSAKRDATLAAKDDATMINLVAEVSHCAVWGFQEVPAGVELVTKFDDINDATENLQSLLQEDWFNHMTTATLPSYYDDERVVLVPLLCTQYAECARLMPMLNHNWLTDWLLRASHKVEPQLCDKAVATVLNAFPADCIRTRKFRALKASVSTLICHGSTVSIGKVKLRNLAALLHKESIENLSCLHSKLKLLKGEAHSSDGQSDTAKVIKLSLIVDEINVACPYNTGINAKSAFPSELLPKIPNEAKLHRKRPRCRNAALYILRVHSSPMVYMELTADTAVVVQNNVTVPLVRTLYSDVRRLEQFTRQSLMNFVDVMEDAKYQALLHLYDATYNEGRAHIISISCESVKASLHALTRTVCYWKDIAHYVAAGSGPRNYDFQPKFMVILNADMRNLNVDICTASKSVYAAKLTLQHAVVTDAWGKHLVDNIYSSRCALGNAGILDEVTFCYQADQVSASLSMVDDAMEVKVALDHTRSELQIDGIIVILGVLHDMGFSKLKNKDKSAENPGTKRPVRMEVNLNLHEIWLYPSIPKGGSIFGDTDASRTVSATSDDNALGTYENSKITVPSVIRSASEVPYGLHLRALQSSGDVDRPLMYTGHVIGFLISISVSSPTRGNAKLKLKYMGVALARVSIIQGVKVLVDEQNDAIFTSLNSDEGLMFEMRESSVKSKLTEIGHVVVAVQASKPKISINIDQMFQLCLLKSAIIDSAVDTFKAYCQLHDGVAVTHEQEENENAESYDLIEEIRYITAKYNLPITNLTDGEGSLYNVRLEEDVRKRLLSQARKKQRLMSNLVKVINKLRWYDGNKQLTLSSVINDCKCTLFSVQNELVLKFNLQHVAFDLTHTAPMCKRQTIVDASMVFNVATYNASLNNHETVLQTTVATLQVAYEDTVFDTPALDISMQISGVAVEVNPCLLQLITQLKHVFTILHSDRHKNRGARSKSIKLYNEIGVGIILIGPRLSREGELDKMHLPAQTYTNVFDKAVYIFIEDTPTGDNSIHLKHSITGRLAVLNGDVSKGRGPKWAIRERKQLLFGNSVNVKSLLSVIRGGKITDGDEITALALSSTTESLRFVGKYNVEQTGSRLFRVPDSEMMLLMEQYHDEGDEPHVILASSVRIQNSTAMPVVMRIDDKVGYFTRVAQKLTQHKPKGEFEEMFLEPYTSSCVPLSWFGSALTPSIALVLSNGDATEAVPFQQLYDILNRNPFSDREFESCNDVVLKFKESLAMKCSIVAKDVASNDDCGSCFYHFTVTIEPMVKIVNMLPCDIQVLIQLYKTQLVEDDVENDETMLHALNSYKVQALLKPGESFGIPFSEQKFFMRVNVKGTQLEGCGDDCKAAVNDIEYLSQLFPVFLPASGATSVVKTLKLHKGSVEGLLQSVYQAHAEALMDFSDHFRSMAVTVDLSRHEIRIWWPFIFENMSQNSLLINGRLLMPRSRIYGNLNDASTCRIQAIMYTYKSGDWTKQASCALSQSVKLDVTSTTDFRPPINLVVPLKNRTLSRMAFSEATSNVEGILGNVVNASNIYHAKRYALQKTFSDGRQSTLNEFPQQHTATMEDTETTACGNAIVCLGSTVRYAEYPYNMCKIVSVSNMYTFVNRLPFTICVRGAPPNDQYLDPPSDGECNDLLILPGESGALNVSLQCAYIIKVENDLCSGLFTLQYPRLPHMFQLELNSNNITYSTVATRGLLVQVNVVSGVFEGSKMPYSYNGYYFVLSLPDKPQYQILNLTNHTLAYSVPENMRSVESQQVESYQSYEQSWERTPMNKIGILPPTCITHYVPAAISKSQEVLQVCLKVLHVDTCDWSVQRVDFVREGCHAIKFVEQRKTLFLYATIMIRSNGTRIIAIVNSKSAAMDLNRMGGSSLSVGPKLQWSSINFNFLTPRITVTLSTKRKVILALHLTNTSATLSIAPSKYDTIEREVRGSMELESSRCSMVDLEATIQSIHIDHFVQGYIPVILKSSAKRSSMQESFLNIRMSLSNFMTRGLPIYETIQVKLSPLSINIEMAVIEQLVDSIENMLRLPLRNVASESTDVARNNCLVMPEPKWVEMEPASPVYIRRLAVEPITLSLAIRTSSTQLTHRTMRVLDALPLDTPCVCVHFTGETRSYLIVSWGELMHSLRHSYLRQLIRQSLPTAWLSNTFAVLYGFVKGVILLVTRPVQTALKFKNALEGFAIGVGNGIMLFMLYITGGTTQSLGNFLNIFHKIIGGQRAKPQGILDALWLGMNLIILHVLYRPWKKLIVDLSNSDSADNTCMKKSMGFALNLAHCAISPLIGVVNMLITVVEGFSNLLLGDVEQFTHVYESDQLGRVPTQNPNPVRPNIERVETTNTQASFIRRMRTSVTLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD81</accession>
    <name>A0A061DD81_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769360.1">
        <property type="nucleotide sequence ID" value="XM_012913906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD81"/>
    <dbReference type="GeneID" id="24565715"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310770"/>
    <dbReference type="OMA" id="ILNIERW"/>
    <dbReference type="OrthoDB" id="363996at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595716" evidence="1">
        <location>
            <begin position="20"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="874" mass="98668" checksum="A2A92433898F6798" modified="2014-09-03" version="1">MNVLGCIAALAAFAASAAAQKCLEFVPVDISIPESTYYVRNESGSRFTIVTKSGKCIGTVSNSGQEISKIPETGVTNRRVSVQRLLENEYVNTDLKPAVEKDGYIYIVEVETIFLGIPNRQKLVKTTTGEYEEYSGGFDDLDICGKSFESFVQEPMRADNTMARLLPKPGRRMGSIVCGDKVLLEQDDEVFFRYAEFSNNIWHVFTTPNVGNSFKTSFLPVAWKDCMYRTLDHGSLYIDLSKDYRTEYCQILSTCGENCVFFDGCSDPDYRVVDILDQKGVVYMGNHARCVQLKMQVVEGTHYLTVYARLLNGLFEAELYRSSDGRNYTPYKPEVINLELTNTNIDERIQVTSDRNGKVYTIPAPNNLLYTIGAVTYMNKTLVGKSFLEDPDKVPYVVLSRRITVVDEYTTVETQTNKDQPTNVTYVTNKDGVWLHRPKPVQFELTQLNANDPNFRVTRLEKGKFHVAAALPNMKIGSIKYKNTIVAPNQSNAISTEFLYDFNELLVTEQMNESVRFHTKYVLRQGFLGDDTMLFVERHKQPHVLKITDVFNDALPEVFCRDTLGKFVKIYVCKDLFNITMGAVTFGDTTLVPYNRYFKMREVYVAEEYFMSYIVVRSFTEEGDSVVEAFRSRVVDGEITFVRMRSKPVTIDLAPEAKAADQVVKVQDGNNSYYRIKPEFAVNHRIGDVRYDGRLLIPDGGSNLCRVLNTTAEVVNGKITEILMYVGDIGTAGRKAKLLTANLEARSLTEVPKRPLEIDISFKGTRDDVVEIAENNDTISYYVPWMLAGGIRLDAVVFTNGQNEVDVLIKDLDLDDIPEVRLHHASDAAQAVVAITPKNLPAIYANVMPTESTQVASTANRLYDEYFKSYYGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB3</accession>
    <name>A0A061DDB3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769435.1">
        <property type="nucleotide sequence ID" value="XM_012913981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDB3"/>
    <dbReference type="GeneID" id="24565790"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311520"/>
    <dbReference type="OMA" id="HIHNVEN"/>
    <dbReference type="OrthoDB" id="361417at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="14619" checksum="89A9F37C8A8DE384" modified="2014-09-03" version="1">MVYTHFGRITKQWCGSTHLRIGSRGQPRPNKGFSVKHFDTVGSALECCRWWKFLRRGTLARILNLQSSSAEASVPGSCQCALLMQLVVTSTHIHNVENGSAKLNDQQLSVLSSYLGVSFQPRKAPRYRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDD1</accession>
    <name>A0A061DDD1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768361.1">
        <property type="nucleotide sequence ID" value="XM_012912907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDD1"/>
    <dbReference type="STRING" id="5866.A0A061DDD1"/>
    <dbReference type="GeneID" id="24564716"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300800"/>
    <dbReference type="OMA" id="QCANEDA"/>
    <dbReference type="OrthoDB" id="365954at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="909" mass="99503" checksum="2D3085A438D958F4" modified="2014-09-03" version="1">MDAVVGTDLFATLWQHLQYTFHRSPHSMNAIHYDKKTLEMKFGAILSDCVGEASKILASDLINVCSDRNIKQSLKLCSRSLKDKGVSPLGKINAMQFVVIVALSNDHNSYKVACSPVLNIIARLGGANNGKGRLTLFGECVNKAHLVKCAKYANSVIETLSKVEAFDLTLHQSLPFGVRCLLHKCNSLRLKQLATGCASLSNAISNVRLPGTSSYSSSVRDAVESAASKSYRTRAKELEYRVSHIEDEMEELGVAVPADPTTQQKPATMSPRSEAKLVDLVSNLGFLRGECSSLLNEMIDADYGRMRADVTTLIDHIKSLEIRCSAASTGDGVYHDLAALNMTFSALKGDQSSLGGGFHTGREAYETSDATRDDCISSYSFKTALNDVASREHWAAEILANENASAKELPQEVHNQKDNKTVLSNEFASLESDNAEKNKHSTSVNSDAILNAPLNVTSDDIVTDCPNNKLAVGEKVQKSQESPDEESHTNERATEPPATGATLVYAQANMAVDSGSEKASIQSDAVENEGKQVPKTNNTNEDMSSSTNETNVVRDGSNIESHEGQIDQDTLGTCISESSGVHDHRPADTDGAEFSSTQSDNTNVQCANEDARLDHAPLNQVSNIDSVNEELEIDDDINQYDLYDNANSNLEGIRNSIVFRDSGIYNDSNLEVSLIQRLDEEEEIGIVADCRLTLENRGVETMHDLRFDFSNFEHFSIHLVLSPMDEMPKEIAPMSSMDIHFKLYPLAPFIGLPKVTLTTFIGPGGVEKNYTLFLPLPVTSFLRCEPLEDLNVLETLRQQSKTYFLARNTVPFDRATQLVTLNNHLSSFELEDRPGSMFMLASFHQCGCPDEKSTGGSRFKVLIMIEAADEPTSFNMHVFSDSDRLAGAVAQLYRYLFHGQGAAYGGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDG9</accession>
    <name>A0A061DDG9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="7">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="7">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0301640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768446.1">
        <property type="nucleotide sequence ID" value="XM_012912992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDG9"/>
    <dbReference type="STRING" id="5866.A0A061DDG9"/>
    <dbReference type="GeneID" id="24564801"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301640"/>
    <dbReference type="OMA" id="GQFAKVQ"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="51"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="750" mass="83482" checksum="F603862F02084B9E" modified="2014-09-03" version="1">MSTRRFSSLLAIKPTRSGKVTAKHGLDTACEGRCRVWHRCFNTGDGHYNIERIRNIGISAHIDSGKTTLTERILFYSGRIAAIHEVRGNDGVGAKMDSMDLERERGITIQSAVTNFRWSVEGAAGESSVDYMVNIIDTPGHVDFTIEVERALRVLDGAILLCCAVAGVQSQTLTVNMQMDRYKIPRIVFLNKMDRDGADPERVIGLIRQKLNIDLLELQVPIGLANRFEGVVDVIDECAYHFEGPNGQHVVKKEVPDGYAELLRSKKTALLEKLADLDDEFAAEFLDNTYTPRSMRDAIRRCCLSHKAYPLLMGSAKGNKGAQLALDAVCHYLPSPADIEQCGYLNDEKTDALDGSHKQPLVAYAFKIQDSPMGQLTFLRIYQGTLRRGQQLYLVEEGKKHSTKKLFKMHASDTEDVSEACSGEIVAISGLKCNSGVTFTDGRLQLTMAPIFVPEPVVSLALKKVDTRDMARLSKALNRFKREDPTFRITVDEESKETVLSGMGELHLGIYVERMKREYGLSVETGPPIVNYRETVTRRVDFCYTHKRQSGGAGQYGKIIGYMEPIGEEANRHLHVEFVNKLVGNDIPPNYVPSIENGFRECCKKGLICGRQVVNTRIVVTDGQSHEVDSSDIAFRLAAKGAFEESYLDSSPIVLEPIMQVEVVTPHEFQASVLSTITKRKGLVTDTSAYGSNVILQAEVALRNMFGYITDLRAATKGQGEFSMEFKLYQPMNAADQEACAKEYQESLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP2</accession>
    <name>A0A061DDP2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768621.1">
        <property type="nucleotide sequence ID" value="XM_012913167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP2"/>
    <dbReference type="GeneID" id="24564976"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303390"/>
    <dbReference type="OMA" id="DHRKICA"/>
    <dbReference type="OrthoDB" id="365223at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="999" mass="111641" checksum="76141F31905BBDD6" modified="2014-09-03" version="1">MKQWIWGKVNELGEKAVDSVVNIVLSRNDKTISDFKQTPLIAAISRSVNSHITIKQANVASSADAAEPGPRIALAHVGLVDSTFLCYPTASTNAGSPVAGTAGRVPREQRGRIHFDGLGSIPTHLCRYRVSLSCNGRVARSPSAEMVDSSVNRVCWNHQVLMDIDDLWVDLNLVVQAEIDFNQFSKQQSKHSSSGASSSSKRSPGSRTSRSRQITRGKAVESDLEETQRIESIYGKTRYKQRIGRALIPLPLLLDSLQLRRTTCLAQDQEYTGMGQSEQCATSTAVEYSADSSPSSQRRTSFDAAPLEQIAQGEGTPRGAVWSTASSISNTANFGTDAVYDEQATYYDAELEDLSGSDEGGQSDGNDYNWFNGHNDWDDADEQASIIRGPVGDGSSRLKAYSIGESYVNMTSIENSTYSSVRSTASPNHNDAFAWVNDYNASPGQLGRCNTAEGDVRRDVVPEYTPERRASVPTGTSGGKQGGVTASMSMTCNRGVENSNWEPADNALRSDIYSFGGPSYNVDSQPASAAPSRHITSSEYAYSEAGSRSWDRQGSGSSMSEDVLKEYRYFADTEMTLQLMPFNEHKFEDHKFVRPIEGYTSYGMKSPTQPLGYITVRIRIYLKRRPQLLALRNCLRPPRTYWQVPSEFEMFHISLICKRAAFFIDTKPRWVNHILLPKEPRKHLWYAIVFWALVFDLMVLAPLPRAVVDLYAMIGVVSCFYWRCMKPMRYDLEDQTFAARGAADSKTTAGRVHRKTGGSLYNLAYDSRQPSAQGEDAMGVSMRVRELHNPPSVATAPTQAEAASQPLLQQPRRKSLWNLRGMEESVSRMATPFGTRHLSLQRYKGAHRWAIFADDLSDTNLEELVKLGLTWAQRVQVILGYLILTLDKLRASLSCTDSLSCMMTWVMIGLLFIPIYALAYLVWLVPPVMWRLAAYCAAAGYCWTFHTSNPFDVWAIIRRVYAWIRLRWIAKFLAHWYLRAPDSREVDHRAIAMLQLTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE16</accession>
    <name>A0A061DE16_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0306640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768946.1">
        <property type="nucleotide sequence ID" value="XM_012913492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE16"/>
    <dbReference type="STRING" id="5866.A0A061DE16"/>
    <dbReference type="GeneID" id="24565301"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306640"/>
    <dbReference type="OMA" id="NTVKCWD"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="6">
        <location>
            <begin position="216"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="424"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="531" mass="58109" checksum="171D19B6F127753D" modified="2014-09-03" version="1">MADGAAARPGHYDRLLRANIYKSLNLFAGEFAAHPFNPLDEFTRRRLSCKILSEYGPVLNYQPKAANVPARSGQSEDSAAPKAAKDAPTINVRKAKTPIAEVVDGLHAALASSRPASSKLAYLDAAVSDEVNFGIVRKRPLLALGAGDSAKRHEHGAIRAVVDGDSAGSSAITSYLRETVAGGHSIATLGIKPKTDTIRRTKPKWHPPWKMYRMIVGHQGWVHCVSVDVSNQWFATGSSDRLIKIWDLATCQLKLSLTGHINAVRDLKISDRHPYLFSCGEDNTVKCWDIEHNKVIRSYHGHLSGVYSLALHPALDVLFSGGRDAVVRVWDIRTKESVHVFTGHSGTIMSLASQRAEPQVISGSQDKTVRLWDLAAGKTLATLTNHKKSIRAMAIHPSEYTFCSAGADNVKVWKCPEGVFHRNIGGHNSILNCAAIKDDGESSVLVAGSNNGQLHFWDWHSGYKFQTLESVVQKGSLESENGIFGCAFDMSESRLITAECDKTVKIWIQDPDATPESHPVVWTPEAASRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA1</accession>
    <name>A0A061DEA1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0308680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769151.1">
        <property type="nucleotide sequence ID" value="XM_012913697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA1"/>
    <dbReference type="STRING" id="5866.A0A061DEA1"/>
    <dbReference type="GeneID" id="24565506"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308680"/>
    <dbReference type="OMA" id="NDPFFDW"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="49"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="359" mass="41054" checksum="C2FBC2A5313522B9" modified="2014-09-03" version="1">MAQEKEEGVGCAAGLIALIKRMFNRKERRKQRCSLEVRTATSKLKKENFEFVRTLGTGGFGRVLLAIPKGVEGMEEPCAVKRQKKYTLIVQKQVDHVISEKKLLASVNHPFIVNMLGTFKDPQYIYIVMECVFGGDFFGYLRSVDRLSSEAAMFYAGQITAIFEYMHSHNIIYRDLKPENLLVGRDGYLKLTDFGFAKVVEMRTYTLCGTPEYLAPEILLNKGHGKAVDWWTLGILIYEMLVGYPPFYNEDPMGIYKKTLECRPVYPSFYDRDAKELTKKLLTFDPSKRLGNLHKGAEDVRTCKWLSGLDFGKLLKKELPAPYVPELKSNDDTGKFGDYPDSMDIPRPVEGRDDPFDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEC6</accession>
    <name>A0A061DEC6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0309480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769231.1">
        <property type="nucleotide sequence ID" value="XM_012913777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEC6"/>
    <dbReference type="STRING" id="5866.A0A061DEC6"/>
    <dbReference type="GeneID" id="24565586"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309480"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707:SF1">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012678026" description="histidine--tRNA ligase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="4">
        <location>
            <begin position="67"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="524" mass="58106" checksum="C1C4A20D5E4A4B9B" modified="2014-09-03" version="1">MFAWYTLGWFVVAWCRCLRRSRDLGAFVAPGAPFVHDGAIEARMVSALGAKSAGKVALYTVRGGQCFLPREQLEQRQLQDEWLALSRIFGFAEYSLGVLAHAELFTGAAGGVATDEHRNELYEFTDRKGRRLALRGDVTPQFMAMLRDQGEAAGGASPCGAVAPSQLSKWFTLADCWRYERPGHCRRRNHLQWTCDIVGVPGPEAEIELLTMLVTFFRKIGLTSEDVAIHLSHRDIVPAMLGVLGKSTSDSQWLHEFRKVLDKYRKVSQPEFEAMLALLGFTPAETAALLDLIANCRTLSSIEGVFPADAAFVKVLRRIVEGLERAKCADWITFDTSIVRGSDYYTGAVFECFDRSHPQSRALAGGGRYDNCLPDLRGDERQLSHAVGFGMGNVAIAELLRSRGRFAPWSLADVVVFTPPSGDEQSTSSGGDLQRVHDVIDGLRQSGLRVYHYYKSSKWQKALDFADRVGAPIFVHPDVGTSGVAYQVHRLADRSKVKLDGDDLERVVDHIRGQVAEHVELQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN0</accession>
    <name>A0A061DEN0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769751.1">
        <property type="nucleotide sequence ID" value="XM_012914297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEN0"/>
    <dbReference type="GeneID" id="24566106"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400570"/>
    <dbReference type="OrthoDB" id="445338at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="292" mass="32855" checksum="5E6893A6742E33ED" modified="2014-09-03" version="1">MARLVSATQEKADKLLVYLARKIGEHKPRNVVFFIVDILCTYYPRHIPNFSKTWLMDKNLDEAKQHVRELFKRNNSTSCIAQHFINAGFDSVSCKCDICDSMQVDSLTCLTTDVLDEIQAYNNTTWLPGHKVRVYQIFKDIKKVVKEYKDSTRSSVMVWQHGDNPVYAQMEGAYITPSQNGASWLERRTVGTSGGPVYYYSQRQTASSLTTINPQSTIHKTSSSLFDTVPLGHSYNGPVIVNNDMTVTQIANKSAEATTNKIIYGLMAKTNAEQPAVKRTGASICCHTYESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEV8</accession>
    <name>A0A061DEV8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770141.1">
        <property type="nucleotide sequence ID" value="XM_012914687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEV8"/>
    <dbReference type="GeneID" id="24566496"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404430"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="321" mass="36479" checksum="A2CAE8F59A10C1FE" modified="2014-09-03" version="1">MVYKSLTEAPHNLKEGIDWLMAVKGTDGEKHLKAMAAAVHHLFSDISARFKKSSSFKEIKSITEGFLQKPEIKDDWLVKTLLRRFYTPDSTENTGFRPYWHKHYDEYGRVVRVKGTKPEFIEECLSNVMDGFEKLLDDIKNPDEYKSAYSSKATWEASCAKDPEACAMVLVGIAPMLYAGLQSLRTTAEFKVGPFHKHTSRKNLGDVLRALGYVEPECRSGMNGSYIYETFRGLDKDLIHNTYDLAGFDIFYASKKAAVKSGKLDKDAQEMIDFYVNMKPINPPKKYVLRKPPSTYTATGSNNMYYPWLPTVLDMGDTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEW9</accession>
    <name>A0A061DEW9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770196.1">
        <property type="nucleotide sequence ID" value="XM_012914742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEW9"/>
    <dbReference type="GeneID" id="24566551"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404950"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="323" mass="35566" checksum="494816FADA940DDD" modified="2014-09-03" version="1">MVYNSLTEAPHNLKEGIDWLMALKGTDAKSNLAALGAAIYDFLADKPVGFTEVPALERVKLITKTFLGKSALKGQWFVRRLRSRYDGYMSRYSPRRGKPMYYLTDSDFNNAVKGKGLTADTIANGVGEVVDGCEKFLDEIKNPDRYESAYSSEATWAKSCSERPQACAVVFVGIAPMLYVGLSSLLDASAGTIFRSNNSELSYGSVQTLNAVGYMVPQRRSTIIVSDFLKALEGVSHEVLVTLYDLAGFWAFFGSKNAAVKSGELDKDAQHRIDFYVNMKPINPPKKKLQFIKSPSTYTATGSNNMYYPGVPTVLDMGDTIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZI3</accession>
    <name>A0A061CZI3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic</fullName>
            <ecNumber evidence="6">1.1.1.267</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0101220</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:13719"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Apicoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="6"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765979.1">
        <property type="nucleotide sequence ID" value="XM_012910525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZI3"/>
    <dbReference type="STRING" id="5866.A0A061CZI3"/>
    <dbReference type="GeneID" id="24562334"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101220"/>
    <dbReference type="OMA" id="AHPNWVM"/>
    <dbReference type="OrthoDB" id="3482at2759"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020011">
        <property type="term" value="C:apicoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051484">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000045">
        <property type="entry name" value="1-deoxy-D-xylulose 5-phosphate reductoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525:SF0">
        <property type="entry name" value="1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0933">Apicoplast</keyword>
    <keyword evidence="20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal" evidence="17">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal" evidence="18">
        <location>
            <begin position="159"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="DXP reductoisomerase C-terminal" evidence="19">
        <location>
            <begin position="298"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR93793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="409" mass="44847" checksum="0B7757BA357F73B3" modified="2014-09-03" version="1">MDVCVLLVCKLADPIKVAVVGSTGSIGTQTLDVIRRMNASSNEPKFKVVSLTANTNVDDLAKQAEEFRPNRLNINVEGSILRDKVADGCHITTGKEGMLEICDSSDYDILVMGISGCAGIEPTIAAAKAGKKLALANKESVVSAGALLRSVVRENGCEIIPIDSEHNALYQCLMTSARDFADHIKQRDEKPLCGLSTNVINSVKRLIVTSSGGPFRDRSLSEMKSLRISDALKHPVWSMGAKITVDSATMMNKGLEVIEANQLFGIPYERIRVLIHKECIVHSLVEFVDNSVIAQLYKPDMRLPIAYALHWPDRTENTLPELDLTKQSLTFTEPDLEKFPCLKLAYEVGKKGGLYPTVLNAANEQANDLMRQDAIAYSELYPLVRDAVEAYNPPNSDGQDIEVRAVETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZJ9</accession>
    <name>A0A061CZJ9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exosome complex exonuclease RRP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0101420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765999.1">
        <property type="nucleotide sequence ID" value="XM_012910545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZJ9"/>
    <dbReference type="STRING" id="5866.A0A061CZJ9"/>
    <dbReference type="GeneID" id="24562354"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101420"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="250" mass="28517" checksum="8D677E07FFF7BDA2" modified="2014-09-03" version="1">MLADCLCHFFAFGISYESFELFLRVLCHHLAVDKLAYVEPLHGKYFAQVGDVVVGVVQKIGGNCWYIDIGSSMRVQLSILQVNTEELANRRKLEEDVYEMRNIFDIGDVISCEVQRVSQNGTVLLQTRTSKYGRLSNGILVKVKPNLMLRQSRHMHDLPFGASLILGCNGFIWLSPSDERNDTTVKAQMYYDICTLRRIILYLAGLGIQISYTIMCDIFDFFKRHCPSDSTLSKEYAAQLVELYLSENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0D6</accession>
    <name>A0A061D0D6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766324.1">
        <property type="nucleotide sequence ID" value="XM_012910870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0D6"/>
    <dbReference type="GeneID" id="24562679"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104470"/>
    <dbReference type="OrthoDB" id="2193044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="8069" checksum="C59C609F45A52D6A" modified="2014-09-03" version="1">MLIYVQSVIPSAHCFEPLIGLPNKQSATRHRSKPWICLIPSGCLRNTVTIVEIGITNQYNLVDTEKFKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0X5</accession>
    <name>A0A061D0X5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0105870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766464.1">
        <property type="nucleotide sequence ID" value="XM_012911010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0X5"/>
    <dbReference type="STRING" id="5866.A0A061D0X5"/>
    <dbReference type="GeneID" id="24562819"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105870"/>
    <dbReference type="OMA" id="GTQVDLC"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="271" mass="29330" checksum="26C9A0FAD35CF8C7" modified="2014-09-03" version="1">MDFSYVRDYMSQHGGWDFANCARNARIKDSVKGFKVLKTGTTICGVLVKEGVVLAADTRATAGPIVADKNCSKLHRISDFIYCAGAGIAADLEHTTLWLENNIELMRLNLKQRPKVQMCVSMLVHELFKYQGYKQCALILGGYDTLGPHLFSVSPRGSSDSLPFCTMGSGSLNAMSVLEEGYRDGMTIAEAVALATKAISAGILNDLGSGGNVDVCVIDRHGAKHTRAHAVVGSRTYAPIPRSIPLGATAVLREKILRIKDQIIVEDIEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1A2</accession>
    <name>A0A061D1A2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0102110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766068.1">
        <property type="nucleotide sequence ID" value="XM_012910614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1A2"/>
    <dbReference type="GeneID" id="24562423"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102110"/>
    <dbReference type="OrthoDB" id="369831at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025677">
        <property type="entry name" value="OST-HTH-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14418">
        <property type="entry name" value="OHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OST-HTH associated" evidence="3">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="266"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41306" checksum="60AC9FF575B3078B" modified="2014-09-03" version="1">MARVLCTQVSTSTNGGDDFCSTGGYYHKLNCCSGLTSAGCVSSYCQSPEAPNNALQWRIDVEVEKVLSNVYDAICELYNEEIFPTLHEIRRKLQRNNASLVDGNWLLRICKNDSYRRFQVFIMMDDTLNAKDHNLQGTLHSYHDFTKIGGRYLFAEHLRKFGPSRFRQLALGKLVRIVQVALDSNILSYNGTNVIPSVSSTTSTKKLLSQIGANKSNLMVRREDQIQAIRNNIILILSEKPPKANSASPGSQTNGPRRGQTIKLKDGDVTISVCKLPVIYKKRFNQDLDFTKGGYSKLTDFLRNEVPECSIQPCPVTQKKEQPKPPTMGDWLINHIVYQPSTNIFFPLAMRSSRLTVNAANSLIMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1L7</accession>
    <name>A0A061D1L7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766724.1">
        <property type="nucleotide sequence ID" value="XM_012911270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1L7"/>
    <dbReference type="GeneID" id="24563079"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108360"/>
    <dbReference type="OMA" id="WWQASEI"/>
    <dbReference type="OrthoDB" id="363957at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="143" mass="16685" checksum="B11FAC7F20DEC21A" modified="2014-09-03" version="1">MAPPERAQSLLQRILRRSQNTPRILWWQASEILYKLQRRQRNDVKQHPCVATCLGVTVCRHKLVRCMRRFPHNATTRCAGEASRHYQCTVKNDGWTAEDGVNYARILDFDIFDTRKPAVFTAEELQRSGIAVTNNFVPNKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Z0</accession>
    <name>A0A061D1Z0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766834.1">
        <property type="nucleotide sequence ID" value="XM_012911380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Z0"/>
    <dbReference type="GeneID" id="24563189"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109460"/>
    <dbReference type="OrthoDB" id="366245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37935">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_14, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37935:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_14, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="386" mass="43058" checksum="8EA3997B23FC2D89" modified="2014-09-03" version="1">MLCHLHIRRCWWRFLPYKNESSGVLIHREAPGCFRSHLLGEYRNISSAAKRPASVNGHRRTIERNLSTQSQRSPVTQGSSCPTEDNSERWSAYEEHIARCASEAAIEYVRRHKLGPHCAPGGGSRWTPVALVLLVVCAGVATVVYVESVRSSLLDATGNAAGVLLHNRAFHDQSMSFLRRLAEDFLNSAETEELLKCKVEQLLLSSGEVLRNTVVDILQQDEVTKTAYSFSRQITEDLCKDGEVIEYVGQLLLDAINTKTAVDGAAKWFSDIAAREDTVETIERLLCERVLSNATVHAEALNLCKSVTSQFLSAESTKRESVAFIKSVLDRPSLHAHLSQALIEVLKQSFYPRWFVGQGNFQLKRFDASVDGDGVQSPKESVPRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D217</accession>
    <name>A0A061D217_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase DDHD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766859.1">
        <property type="nucleotide sequence ID" value="XM_012911405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D217"/>
    <dbReference type="STRING" id="5866.A0A061D217"/>
    <dbReference type="GeneID" id="24563214"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109710"/>
    <dbReference type="OMA" id="GFYKFIG"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="203"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="563" mass="64137" checksum="772FFFD788E74037" modified="2014-09-03" version="1">MSGRDSSKLSGNPDGKGNVVEEQERQYERLRDKLHLSNHDSASEVDFIIFMLHGIGSNSNVLGADYRMIKYSLSSIKRHWFYHDKLRTHVHLLDWKKHIIDAQSMLFDHTYITTAKETRKMITSHILDIGFYLNPRYCDFLLENIVAELDGEISRLRHHPSGKFRNSKIAIVGYSLGSLILHEILCGNPGRASNLRPEDRPKLRSKVDYMFCVGSPLSCFMIFQSPQYMATGMCLPEGVEAYNIFHPYDPVAYRWERLIYRDVKELPEPEILPYWQNNGFKNWYGWERSVQQAKTMIVDNISDVASTIGRSIFGWWGSSKSNSVLANNVANPDKRSAALSSFKLKLKERTTPDNTDLTTGIINPTTSAVDAAAEPRAEERTEHPSEQDQWSDDAEGGDAVNGLFDEERLAAQSAKALHDMNKQAGGHLRRRYDFQLQEDITEHLLSPLGIIQSHTNYWSSKDLMFFILKKLKKGHARVSITTYFKSIRLRAKWLADCAANDELKAKFLALSEEASACADRVAAEDNKARLEAAATFSSTWSNFMKWSEEYCEDAEHVCSDPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2A9</accession>
    <name>A0A061D2A9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767077.1">
        <property type="nucleotide sequence ID" value="XM_012911623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2A9"/>
    <dbReference type="GeneID" id="24563432"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200480"/>
    <dbReference type="OrthoDB" id="366829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="262" mass="28897" checksum="76A19762209909A8" modified="2014-09-03" version="1">MRHWNLREALDWLIQVRHCAKTSTLSDNLCKPFHNVAHDVERYLPPRTASEEPSACDVISRLSTLQGSAPEDSANPNKNIIHNLCASAASLLGYRSPGTYDGSGIVYGNALRLCDAILAFLYAVLSDVHANQPYVAGKYLLYDVIVEIKSQLWRGRKGFRQVIPKVANDLERYNAAVKASNEKVKKPIETVLHYVKPDGELHKGIQALQITETSTSTQDERTVESAVSLVEGCKEVAGVFSKGLTAATNAINDLNPKLKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2L0</accession>
    <name>A0A061D2L0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767202.1">
        <property type="nucleotide sequence ID" value="XM_012911748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2L0"/>
    <dbReference type="GeneID" id="24563557"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201730"/>
    <dbReference type="OMA" id="INMIGHR"/>
    <dbReference type="OrthoDB" id="366275at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595908" evidence="1">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="22717" checksum="1D5449C45E1B0A64" modified="2014-09-03" version="1">MKAVLAFVLSFILSIVNVNAGEYTVLKSLSTTEAARLGKPTEKQADKQDPSRHNMNRVMVDCYTGISKSALPVIQFVMMGAVDHLQKKLFKDVSLIITRHTAPTSGHKSFCKDPTLDVCLEKIEIDKNAKITNRKKIECVKTGNLTQQGTRMRVTFKDVFKNPDMDYESFHVTMSPKKSCRYNLIVELEEPNNYGDTVPKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2T2</accession>
    <name>A0A061D2T2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0106910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766568.1">
        <property type="nucleotide sequence ID" value="XM_012911114.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D2T2"/>
    <dbReference type="GeneID" id="24562923"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106910"/>
    <dbReference type="OMA" id="DEWITIH"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902850">
        <property type="term" value="P:microtubule cytoskeleton organization involved in mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000996">
        <property type="entry name" value="Cytoplasmic dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="DYNEIN HEAVY CHAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1933"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="2226"/>
            <end position="2630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="3018"/>
            <end position="3049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="3207"/>
            <end position="3283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="3479"/>
            <end position="3506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="4173" mass="476320" checksum="88A8E484F0786AAB" modified="2014-09-03" version="1">[encoded data, 4173 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2W4</accession>
    <name>A0A061D2W4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766613.1">
        <property type="nucleotide sequence ID" value="XM_012911159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2W4"/>
    <dbReference type="GeneID" id="24562968"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107351"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107351"/>
    <dbReference type="OrthoDB" id="366130at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="94" mass="11136" checksum="AF6C1023A9ED4847" modified="2014-09-03" version="1">MSIAAVAKTWSDFKQRKVNDIWTILLSRVFTEPNVFYASSTLVFTLLFLLIFAYYKLRGLAKDYHNIVMIKRNLEAIAKSRLKRYLLQSAQFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3P8</accession>
    <name>A0A061D3P8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767507.1">
        <property type="nucleotide sequence ID" value="XM_012912053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3P8"/>
    <dbReference type="STRING" id="5866.A0A061D3P8"/>
    <dbReference type="GeneID" id="24563862"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204790"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="168" mass="18834" checksum="BA1D95853965490D" modified="2014-09-03" version="1">MRQPCGRYDWYQDANSLSIVLYTNSVVPDSVNVAWSNGTLSITYTVATSSDDGVATNESNSGEANRIDLTLFAPIADSCGASNVYNIECSKNKVEIRLPKANSGWWPVLEKKRDLQSTKPPTYSKLLRDMYARGDDDTRRAMAKSFVGLFTGIERRGTEHIWRYCAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Q0</accession>
    <name>A0A061D3Q0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766883.1">
        <property type="nucleotide sequence ID" value="XM_012911429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Q0"/>
    <dbReference type="GeneID" id="24563238"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109950"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="194" mass="20975" checksum="F40F5475D6420138" modified="2014-09-03" version="1">MPAYKYRWRNPAGTGWRLQRLRGLSAAVVEGTGSGSGTCCGWLSGRGGEDERLWAAVRGSSKHPYVCDESRCGEQCKNKEKTCQCTCCKKRCSQQLGQCSPAAAQLSLSSTGLQSQSDSQALSSDLPTEKTDAENSDTDVSPGPSISPETIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3X0</accession>
    <name>A0A061D3X0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA pseudouridine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766938.1">
        <property type="nucleotide sequence ID" value="XM_012911484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3X0"/>
    <dbReference type="STRING" id="5866.A0A061D3X0"/>
    <dbReference type="GeneID" id="24563293"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110500"/>
    <dbReference type="OMA" id="GAIHESH"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="439" mass="48456" checksum="223027DE537A23BD" modified="2014-09-03" version="1">MSRDKRILDGAPDDAAGEPSPKRAREDTESPRENDQALGSNSVDTVSAPRVHVPKTKYAIAFGLVPIVIQSGPGSEHVNTVEGCMLDALFAAGAIHESHRSLIAKLQLSKASRTDKGVHAACTYIGGRFELSHLSSGEPDVSRENALVSKLNELLPGDIRCFQVLRVTRGFCARYEYVFPEWLLRKRYVLDDESKRELFSKLSEQMGGNLQSHDHISCPRIGRGPSNGYDGTTEDRELDLASLESILQAFCGSHDFRNFTPKQKGMENTTQRFIHELKACGAPHRFRYRCCDRDGDGAVLFVQPDSQDDKSGVRSCAIPFTLSKRHVVQTALAPAEGLFLHHPSFDAYNKRCAPPQTPFIEYEDVEAQVEEFKQARLYPEIVSSFEGDVWSTWLTRLVRNPFFLENCDFRVSGEQPTGAKGTAAPGAAAAPDPAAGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D405</accession>
    <name>A0A061D405_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767652.1">
        <property type="nucleotide sequence ID" value="XM_012912198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D405"/>
    <dbReference type="GeneID" id="24564007"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206240"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595427" evidence="2">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="334" mass="36756" checksum="A9D8FAC7738BB49E" modified="2014-09-03" version="1">MQWLCQLIAFLLCTINVVDVSVATPSPSCSKEGDEKVFFPVHHLLDHLEQRKRNVDVTDRGAASGRRPSRWSLREGGRTQNGRRPRYDYGRQRSPIRTGKSGNSKYAVSRARRSSSSGIEGGFNIVDGPHHGGALPQTAIPSVKNVNFEPSNIHLSPSSANMKREFEIIPVIPLTDAKIKPKSRYENPATHYVLVPKVVDYTKYAAVLDKDGNSQNGAVTATLPSTSPKEGGRNDPLEGQHGVDDVQLPRPKQLTNGNNDEGENVKTSRTYPGEIGKARSFSADNLARISKSCELAQELRSNIINHVERCGQEPVPLRVRKICGSCCKKKRAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D417</accession>
    <name>A0A061D417_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0204510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767479.1">
        <property type="nucleotide sequence ID" value="XM_012912025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D417"/>
    <dbReference type="STRING" id="5866.A0A061D417"/>
    <dbReference type="GeneID" id="24563834"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204510"/>
    <dbReference type="OMA" id="MSMQNAN"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="180" mass="20542" checksum="4B71272020997028" modified="2014-09-03" version="1">MLTLRRATMYDLVGTLDCNLVNLMENYKMDYYFYHLLTWPQLTHVAVGPNGNVCGYAMAKLEDEIERAGHLTSVGVLRSYRSMGIANNVIKQGHASMDAVYLCEAVYLFVRVSNWAAHTLYKHKLGYSVDEVIREYFQDKEDAFSMKHVLPLGKPVRFWSHTPSGRERKKTSTRAQAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D492</accession>
    <name>A0A061D492_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767579.1">
        <property type="nucleotide sequence ID" value="XM_012912125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D492"/>
    <dbReference type="GeneID" id="24563934"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205510"/>
    <dbReference type="OrthoDB" id="424606at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="138" mass="15831" checksum="995C685BD93C34A3" modified="2014-09-03" version="1">MPLRLPVPLVLLAKAKHNTHATIRMCSSAMHRPSLSRRSNDVIGDSFTRRSFGSYIENYYTTNHAATGFSSPLRKTFVFVVFVFQAVFTFGYLFHTNYYFTGKALPKPDSSTQLTWRSPTRQDRRSKPCLRPMPQIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4P6</accession>
    <name>A0A061D4P6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">WD domain, G-beta repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0102480</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766105.1">
        <property type="nucleotide sequence ID" value="XM_012910651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4P6"/>
    <dbReference type="STRING" id="5866.A0A061D4P6"/>
    <dbReference type="GeneID" id="24562460"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102480"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="493"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="734"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="1070"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR93919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1278" mass="144552" checksum="1137A9A9D1246E4D" modified="2014-09-03" version="1">MLIKCKTKSPRVKGITFHPSLHFLLASMHSGEIQLWNYLNSSLVDVFEYHEGPVRGIDFHPLQPLFASGGDDTNVVVWDFKQKKMLFAMSGHNDYVRTVQFHPNYPWIVSSSDDQTVRIWNWQGRSCISVLQGHMHYVMCARFHPSKDLLVSASLDQTARIWDITQLREKNCAIQGVVGQSGSNLLSNVHMISCGNGHSAQSDLGRKTDRVPFTDVTCLYTLVGHEKGVNWAVFHDVLPCAITASDDKTIRVWRFNGPNIWQTNILKGHTNNICSLIMHPNNINYLLSVSEDKSIKVWDTKKWTLAHTFMLEKDRFWIVQSAKDSNYIAAGHDSGLIVFKLFKERPIVTVVGNTLYYVWNDSIYSSNIEKELELSREEAKKSTPEVAEVKEHRCVRHCAAHDDHSHGMTLDDFLGFSTCMHQNSLENQDKSQIRDDLVFPSPSGDFCKKNRTKILLINGVADSESIVKRFMTALLIQTPIPPDVGATGGLIFPFSMHYNHYCADKSVFLVNYNYKGRSFYEIMIRENATNNLSDHRATCHIGEAVSSCFVSRSLVAAINPSGKMTVHNLDGEEASEIGIDMKLDKIFSVCVNIVLVWSSSENAIVLYDVAMRKTLCTAHGTLGKLCDVIVSKSKKLIAAVYRKFVVIFDRDLKKLASVEMQGRVKTAAWHENNALFFATSDRIYYLMVNGDLGVMRSIDKPVYIIRIKDNALYVMQRNHKCYKMEIVSNEFLFKMALYHNKIETAKKLIETGKVHGYAMVSYLIEKGHPSLARMIIRDPQMRFDLALSCGNLDDAYEDAQVLDDVEAWKSLGDAALEQGNCVISEVAFQKAKLFEKLTMLYVITGNTIKLKKMMNICKFRNDIPSTVQHALYLGDMGELANILKENKKSKLAEICEATYAINGKAAEGGRPNTFYMVPPQPVHRATVENVNWPVTPLEAVVREPLCYDDADAGEADIDIVTMEEANQNKPSQVNADIWGTIDEIDSMEYANDSANVTEEAEEQCKIHDSRCRSPLDFISIGETGRALDALERSFGLDDRASLEEILAKAHISSEASHQSQSQYAENWSRILNHEHVAGIMNRGYAHVTAGAFEDAITEFRHALKHWIFLVSAGSRDYIDQCRIYVTAMLLEGERERLAETDTRRSLELAAYFSCCNLLPQHQYLVMRRTMGIMWKAQNYKTAARIVTRLLSQDVSSIEGAEEEMQKAKKIYALCEQKGIETYSLDYDEDDERDLNICTISLVKTQGQPTVQCRFCNAVALEKYVSQICNICRLCKLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Y0</accession>
    <name>A0A061D4Y0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA recognition motif. (A.k.a. RRM, RBD, or RNP) domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0207780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767809.1">
        <property type="nucleotide sequence ID" value="XM_012912355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Y0"/>
    <dbReference type="STRING" id="5866.A0A061D4Y0"/>
    <dbReference type="GeneID" id="24564164"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207780"/>
    <dbReference type="OMA" id="HAYQGTG"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000359">
        <property type="entry name" value="CUGBP Elav-like family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="215"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="353" mass="38520" checksum="3BB41D6D48B4CDD1" modified="2014-09-03" version="1">MVSISQADAAIKSLNNNCVVDTALGAILVKYAAGEAERLGFTSLVGDPGVNECKLFVGSIPKTGDESIVREIFEQYGTLEDVFVMKDQNGAGKGCAFVKMAYKEQGLYAIRSLDGMKQLEGCSRPMEVRFAESKANKQNNAGMHHSSMRAPMVQPPYPMPTPSQVRQVGIWREYISPEGKPYFYNEQTGHTQWERPPEFDNPSGASQAPAGPPGANLFIFHIPNEWTQYDLVRTFSQFGKILSSRIASDKSTGRHKGYAFVSYDSPDSAAQAIQHLNGFTVMGKRLKVTIKKGDESAAVSATPSTAPAVAPSSSVVGRMPTPAYQTYQSPHVAGAQPYGQQPYYGSYQRYAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D507</accession>
    <name>A0A061D507_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-related, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0209240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767957.1">
        <property type="nucleotide sequence ID" value="XM_012912503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D507"/>
    <dbReference type="STRING" id="5866.A0A061D507"/>
    <dbReference type="GeneID" id="24564312"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209240"/>
    <dbReference type="OMA" id="MKEESCY"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="536" mass="58731" checksum="05D81A2C0F46F046" modified="2014-09-03" version="1">MDAVAYAALPRVVLDNGSGNLKFSLASSKKPPTVMPNCIGQPKRKFTSQSFSADTSHSSPSDPLSYAEHGESIGDACYTLWEYFCLRPWADGLLYEPNRQRTIWNKIMGRPHIKINGVPANMLAIAPANAALCITEPNMAPGMCRQTLAELIFEDLGFSLAAIMSSQAASNWYYSVAKNPASGAASDAKLTAYPSASAAPASLPPDTACCLVVDCGFGSSHCVPFANGKPIQRAALRNGLAGSHLNAYLKNVSAIRTINLEFNELLVQHMKEEACYVSADFNLEMRAARQLRRIKGSSWLTHDYVLPTYGGKSKSHLHRHFNNHSVSAPPLLTDERRPVVERLARGATLTPEDLEAIVPQQSADHANGDQTAENNRADGQTNGDMQNTLEAANIIAEETAKEDKKANNHVVGLFNERFAIPELLFSPQDLRLNECGIAELALRSIALAPTCLQRYLAENVLLTGGSTKFPGFTERFYSELRAMLPADWNLQIYSAEDRALTAFYGARLYARDDTAFLETAVTRNFYLEHGGIYPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D530</accession>
    <name>A0A061D530_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L29, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767859.1">
        <property type="nucleotide sequence ID" value="XM_012912405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D530"/>
    <dbReference type="GeneID" id="24564214"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208270"/>
    <dbReference type="OrthoDB" id="364954at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595473" evidence="1">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="21458" checksum="25C013CCE9B01747" modified="2014-09-03" version="1">MRATACCEGVLVLFLLFKLAAYRNICTAYTTCMRRCPHSLASHRIPSSTAANSCFSFGGRSADTHRKYCNFWSSLGSRTSIETVIHTGDCEDYDVNCVQYRKARFWRELSTPEIEEEIRKVRKVLAKINLYRKTKNPALRASSLGNTRRTLAQLLFIRHERHLASLREAQGLKKHVAVSGSSDETSNGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D588</accession>
    <name>A0A061D588_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome regulatory particle non-ATPase subunit8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767393.1">
        <property type="nucleotide sequence ID" value="XM_012911939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D588"/>
    <dbReference type="STRING" id="5866.A0A061D588"/>
    <dbReference type="GeneID" id="24563748"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203650"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="305" mass="34734" checksum="61C550A47ECFD508" modified="2014-09-03" version="1">MEFTSRQMEHMKKIPFLGSHRKVVLHPIVMLSVVDHYNRCAQGTSRRVVGTILGEVIDGDIHITNSFAVPFEEDAKNPLVWFFDHNYHEHMFTMFKKINTKEKVLGWYSTGPKCKPADLEIHELYRKYCPNPIYVIVDITQKEELPIEAYISVEEPTSDRRFRRTFAHVPSEMGAFEAEEVGLEHLLRDLTNVTTSTLSKKVESKISALKSMTTNLAEITDYIKGVISGVYTVNPAIIYMLQNILNLFPSTDTDEIVEAFTINMNDTALAMYLGSIIRAMLALHNLIDNMAENKRIAGEKSKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5A7</accession>
    <name>A0A061D5A7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mago nashi protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767408.1">
        <property type="nucleotide sequence ID" value="XM_012911954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5A7"/>
    <dbReference type="STRING" id="5866.A0A061D5A7"/>
    <dbReference type="GeneID" id="24563763"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203800"/>
    <dbReference type="OMA" id="IRKEMWI"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="193" mass="21993" checksum="F5973F38BCD9E7DA" modified="2014-09-03" version="1">MAEDGFYLRYYVGHEGKFGHEFLEFELTSDGKLRYTNNSNYRKDSMIKKEAFLTRAVIAEMKRIVLESEITSEDHTDWPIPDRVGRQELELKIEGKRYTYSTSKIGSLSDVQNSKDPNGMRVFYYLVQDLKCFVFSLISLCFRVGPQCARGSHPCRSGPSEPASGATSPSRQVATAYRNYGINEAVELKLLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5C6</accession>
    <name>A0A061D5C6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">rRNA pseudouridine synthase, putative family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0104780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766355.1">
        <property type="nucleotide sequence ID" value="XM_012910901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5C6"/>
    <dbReference type="STRING" id="5866.A0A061D5C6"/>
    <dbReference type="GeneID" id="24562710"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104780"/>
    <dbReference type="OMA" id="KYGRTNE"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="5">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="268"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="417" mass="46847" checksum="5ECC9A313A4CBA5C" modified="2014-09-03" version="1">MSKKSDFVIKPQKAAPPIDTSEWPLLLKNYDKLNVRTGHYTPLPHGSSPLCRDLSNYVKYGFINLDKPSNPSSHETVAWIKRILRCEKTGHSGTLDPKVTGVLLVCIDRATRLVKSQQGHGKEYVAIIKFHSQPESRSKVEKALQTLSGTLFQRPPLISAVKRQLRVRTIHETKMLDYDEAKSMATFWVKCEAGTYVRTLCIHMGLLLGCGAHMQELRRVRSGNISEYDNMVTMHDVLDAQYLLDNTNDESYIRRVISPLERLLTDHKRIVVKDSCVNAICYGAKLMIPGVLRFENGIELNEQIVLITTKGEAIAIGIAQMPTAVIASVDHGVVSVIKRVIMDRDTYSLRWGFGPRATEKKRLQSAGMLDDRGKPNEKTPVTWLKSEGFIPPMIGEDAKKRAQEGDEAESDAKRPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5H0</accession>
    <name>A0A061D5H0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766400.1">
        <property type="nucleotide sequence ID" value="XM_012910946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5H0"/>
    <dbReference type="GeneID" id="24562755"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105230"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595813" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="98" mass="10722" checksum="88FE6FA18D245E88" modified="2014-09-03" version="1">MVFQALLRFMWHELMLTFAGVELQATTSTNHHTVTTTKQYTGHVVEVHVETTDPCLQGCGVTYASTELFKPETTSVCDAYGREIGCKIGLHAAGNAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5H7</accession>
    <name>A0A061D5H7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768162.1">
        <property type="nucleotide sequence ID" value="XM_012912708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5H7"/>
    <dbReference type="GeneID" id="24564517"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211230"/>
    <dbReference type="OMA" id="HEKYIHS"/>
    <dbReference type="OrthoDB" id="361812at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="475" mass="53199" checksum="6F5BA2A3A0FCF466" modified="2014-09-03" version="1">MKAFVSRLFSRSQSTDLPDKAVEEPAGDDVAFEQEPLLAGAPSRQHTGDLRQRVAPAEEDARYDYVQLDESSSSSDTDEGVDTMEEIYSIGVTDRQDKAALYGRMMHYYAEKAGTVPPMRSKSVLWYMLAILISNPIIGLYTMAHFKDWDKWVSKRAASGEVQVDPIPRAYPTVSPTTSMNIFRASQEHTAGPSPGAGAIMTEDGLERLSLVAKHLSGEITWYAWYEVFGELLFALFSLALLCASGICCANGRQRAQYMIPMIGLLYTAIYKVLAMYILIISFKILHFYVVAAFPRYGEVAPVVVLRMLAIPGTDPTDPMQREAMSYLLALDSFAHKWVLVYCLENVYITITDSVETIQALGRILMRSARKVVRRLKRQQDLVYFTMNPAMDAQASVSRVSNSSCSYLLLDSLLNRTADPQEAYIHDMYNKPGPDVGTYLDNIKVEQYQDGIARIGPKLMSQLRQSDKRVMQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5L3</accession>
    <name>A0A061D5L3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768202.1">
        <property type="nucleotide sequence ID" value="XM_012912748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5L3"/>
    <dbReference type="GeneID" id="24564557"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211600"/>
    <dbReference type="OMA" id="FITMLDE"/>
    <dbReference type="OrthoDB" id="365305at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="26473" checksum="A834C9A94AFA8940" modified="2014-09-03" version="1">MSGGLGEGVFSRLLSLWQKLRGETVRFVDAVTNPVSHAPSEADENDGKISDVSPASSLSTEEGLDDMLALEGTTSGRLSTNSDVVDTTNEFITMLDEVRCDGECLKETLDASCANNRTDVPLEDLLEVTVGLHKNVERRVDDLLEKLSDKGVSIECPKAELPETIPEAVHVAGAKEKGLALKRGRCRRSQRNLYPTPKLDETRPHKVPKKVAPTDLKQLDLSKETRELLELDSPMHSKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5R0</accession>
    <name>A0A061D5R0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0210410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768074.1">
        <property type="nucleotide sequence ID" value="XM_012912620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5R0"/>
    <dbReference type="STRING" id="5866.A0A061D5R0"/>
    <dbReference type="GeneID" id="24564429"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210410"/>
    <dbReference type="OMA" id="MEHAVGK"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="77" mass="8154" checksum="A0ECFB0C38A5B4AC" modified="2014-09-03" version="1">MILASDSSQPFKVLSVPENAPFSAVIKFSAEEFKLNPNTCACITSDGVGVNPSQTAGAVFLKYGPNLRLIPRDRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5S2</accession>
    <name>A0A061D5S2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNAse P protein subunit domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0105930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766470.1">
        <property type="nucleotide sequence ID" value="XM_012911016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5S2"/>
    <dbReference type="STRING" id="5866.A0A061D5S2"/>
    <dbReference type="GeneID" id="24562825"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105930"/>
    <dbReference type="OMA" id="FCKGCNT"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="166" mass="18829" checksum="45F26B1F21986483" modified="2014-09-03" version="1">MDQLPKQKDVTPAKGRDRCEAAKAAFAKNVHVKRVSYLLNAAVNMANDYPNISRAYIRELREIANKHVIRLDPSFKLNFCKGCNTVTLPGINAVYTAECHQEWHRNVPGNQGVRDATSCAPEMPGHYDKPPDDNQFDELSYDWLAVTCCVCTRTRRTKLKHPEVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Y3</accession>
    <name>A0A061D5Y3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767613.1">
        <property type="nucleotide sequence ID" value="XM_012912159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Y3"/>
    <dbReference type="GeneID" id="24563968"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205850"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7678" checksum="8F181CD146559CBC" modified="2014-09-03" version="1">MVYTSLTEVPHNLKEGIDWLVALKGTYGENNLKTIVGAIQKFLSYHRLHKPQEAKKHLSYENINLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Y4</accession>
    <name>A0A061D5Y4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766505.1">
        <property type="nucleotide sequence ID" value="XM_012911051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Y4"/>
    <dbReference type="GeneID" id="24562860"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106280"/>
    <dbReference type="OMA" id="CRMITIQ"/>
    <dbReference type="OrthoDB" id="359083at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056349">
        <property type="entry name" value="Microp_apicomplexa_10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23519">
        <property type="entry name" value="Microp_apicomplexa_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="98" mass="11186" checksum="2976D2A9AC6D8F20" modified="2014-09-03" version="1">MLAQCCRLSRLRGGTPTPFWTTYVHSPGLRINVRYAYWPPPANKRSRLIELVDALIAVYLLVLTSVQLPSGKKFFVFRGKRDADGKLEPVVCFIDRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D621</accession>
    <name>A0A061D621_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766550.1">
        <property type="nucleotide sequence ID" value="XM_012911096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562905"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106730"/>
    <dbReference type="OMA" id="EIRQCAI"/>
    <dbReference type="OrthoDB" id="363976at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1840" mass="205033" checksum="86A348C709BA34CA" modified="2014-09-03" version="1">MLSSRAEKAPAETKRSPVTEALQAMEQKCTTFLDALKLCAKESAKIGSGMKSKFSELSHNITSFIKTLHKGNDAKLLLNFPTKLTCCTLLEGITFANHKTKSLVAHNTAIQQLFGIIEFLYQRSSLNAAREEPIRIGLDNNDLYIYIDMIFKMFETIAKLHKVDESVHLRTVQTVLLSFSTSSPVMLYEDILRRGFQYLDTMLKGDSNVLKPIVEGGVRQLVQCLLSNSRKRKGAFGKSNTMLAELGSHGVVSTISPFGMTTGATTGLTVFSAAPQISHVDLTVELITCLCTIMKGESSEFMLNLGPASAAELLLIAVTAMPKGSLFEVPKLQTVAKSEMYTALKFALAGATLLNEGCAILAKVMEHGYYYSNHCPEPDRGAAKLFTMLYNFVELDLIETSTPDGIRRRIAWIRGLSSVMQSNDMLDDMFAHKTSRKHLVEMLNFIVKHFRMNKEVSLDQYFEGIYKCGDGQQLISEQIDSLEQDGAHNRQVGMKVLPIFAAKLEQGSCAMDFCNMTNGVIGKTSRIVVSDDMNMQQLEMVESALAVDAVLAAAHVLYSCVVGANSHKPSFAAYRIFYPKVAGDYSATHRRMGSSDSVGSSDSVSSAKDESAIDGRCRYLNEAGDILVQQLERMLNTMRSPVMQEVLIAAMQATLVVCNVYGWQDLYTRCVNALVAHFVTVENQFVADHRKCTMETWSLYLLHIRCLNAVMLNYPSALQDLAWESFLEHLLSFVLISRRLGVANRSHLRSLEPLETDAIMPTFKGLQEEWEATLTETIGAFDRLKVHDFEVLKGFVTQFGFHVAIPLLAKTQYTDIFAQQTESRSGVSSREKLALIQRTLDAWPDQFLSMIEKGDQVWPELLRELGQSLDRQSVLASAEPEFLHCLFTIITELSFARQHDSVMLLTGIVMCLTRDRGGIELMIQTICGNIVSLCLAGQQSSARSIDAGVCVLYKTLRDNSALSMDIMNGLKTVCTTVPQIMALSTGIINCLMYATQMASQSSDSNATIILIDVFSALVDDSAELLQDEACLPFVESIFMLSQGAYNSDNNAAFRVVALVLDFAEKMAAQSHYFGAARPPRAKEEDMWKSIFKGLKELGHSEFTEIRQCAIKSLALFIKGRLNRFEMDLWQLCCREMLKPLAEGLVCSIHTPSAHQTVFTACEELYVAFKDCEPRYREKCEAVIGILVTGLETVVNATIGNKMMLPNELNSALGMAISIATNIVIDYCRNDFIWNKCMNIMRAMMHKDFDLLRQNFFKSICSILTALSEQEEGIEEKLMQVIRMALGDPTKEEAQELEALATATSEGRELSPWLVVPPWILSGPVPTGGSSTEVSADYLCEEVLGDTVQAVPAAPLTLYETLKLADDSKIKFTLRDKIQNSVGILQEMQMLQLVTLHYTPQILGGTDALGKVTPEDVQQALENNASEEPEQHRESHSILGAILTSEERAMVMANIVAHCKEPPLITLVETYNPVSKLFRSLGSIKSPAVYGMLVESLINKYLMGNVPKVALALQLIDKIVLSVRDMLIRFITESSDAIVNENKQAIQEFLASKTYRILMCTVLPMVPLILEIAKMILVKHTMQPVALILYQACINISKYIYLALYVNMHFMQVNTVASQPVVDFWRAVVPAMHFFTTLNYNDELETRIKYIRLLHAVEVEVITAMVVNPFSVAPPFVYSSVASVLNRFAGGHSAVLRRIALQRLSDAACYPFIPRPADSSLNIPPLHPAAVRMRVVLTKHFFFVLASNMHQFLGNKDCEIEMLAALKVVESISTLPNELIFDHEYMRKHKYLRYVQKRSLASLTMPALLELLESENKRVIRAARRILSLFLEEMGAQVTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D674</accession>
    <name>A0A061D674_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768244.1">
        <property type="nucleotide sequence ID" value="XM_012912790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D674"/>
    <dbReference type="GeneID" id="24564599"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212000"/>
    <dbReference type="OMA" id="QTIGEMF"/>
    <dbReference type="OrthoDB" id="364788at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="117" mass="13254" checksum="2BCDB58B69EE9EA1" modified="2014-09-03" version="1">MPLDQNEDAPAANVPQNDADSAEQTIGEMFMEAVTAVGSTMRTMFVEANRYMRNCVYPVKQRCVQLYDDMTNNFSAKGTRNSTSVPRVSRQLVLLPSLYRKPTELRCDKLHVRASTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6D9</accession>
    <name>A0A061D6D9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767768.1">
        <property type="nucleotide sequence ID" value="XM_012912314.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D6D9"/>
    <dbReference type="GeneID" id="24564123"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207370"/>
    <dbReference type="OMA" id="EVVISPM"/>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595836" evidence="2">
        <location>
            <begin position="17"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2258"/>
            <end position="2279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2328" mass="252096" checksum="A54CD262DECE20EE" modified="2014-09-03" version="1">MFAGWWLLALFGACSAAVHAATGGSGLTLTPAQVLLPSTSYYVDAGAREPLKVHVQVLLRVEPRVCVNWEVQNPELLRLFPPNNEENYIEYSIVPLSSFGEGCSSSIWAASLPSALRAQSSESGAPLRSWVFAYEASTKTRAGAEVVISPMRSIQFETRNRRISVNQVATLKIVGHDEFANTFTSLEGIPFEAQIEDPRIMEIIDLRHDPEVATRARVSLLDKRDRFAVSQGSTLTSDVIVLQGRTVGRTRISVRVMLPEYREIVLKDVEFTVSDSIDLEPGRLVLPPGAQFKFCVQKIKPQSQIDDTWDPTVDLTNYQWSVAGGAGQLVKPDGTLTTGKAGGVDFRVILTDRRNSETFVSDISVRVPQSLGLSYGGLQQMLDCYATKGVDIADTSNLPHNSLLAQLQQQVYAGCRGGMRCGLRYLAAAAGATPPAYLLLGRSYVFDVGMRDKDDTAIYVAEGYSFSWRVENAAIVGVTRSPNGRFVVITALAEGVTKVAVELAAPRVSIEFTVSVTDPVHLLGFPVETIDVPNQQGLQQVPRSEPLVGSTRPLVVPLNENAKLVARGGSGEYLWHVDDIGMCSTKQGVLRCKAYGSTVLTVSDRLNPENVFKVQVVVQRMKRLELLPAQVHVEVGATAQFRLSAFADLADLAPVFSKSWGTASGEVGRFYSCMPLTYQVESAANAKLNCRVEHDRFMLDLTKVTEEPFSCGVFAYRTLHPGESEVSVSLLHEESMVMTELTASAKALIYDRLSLSVHPEYSQFPLKTPPQPFMNVSQAMADQSVFANVPIGGKVRLVVRGGPPMLANGLVVSTCNRSSAHLYVDKVDNAREGIVSGRTMFDVYCVAETAGDKVCVRVDGVLRNEYTISCRLPSYVEIHPLVSANNQTVRDNLLHCSGYPANWEDGDAVPTGVFSSGSNLCYKDESKTKWQIKTNADAMHAFRAVVFDAFGTPLCPSHSYKVHWSGSAAAGAAKSAELPFQKIDGSMFVYESTTLADSDIVADLEWPDALDPRHTSAGAAAVLKPKSVTTQIAASKMWTKSTSRRGGYLLSTSLRVQPTLPHEILIGASRTSLTPAEKRVSIFFNPRMRYQFAVALGSGNYVELTAYSESIKLQHSTTLTFSSAAEFAKLAAVVDGVTNLSDPLDLQKSVARYANTAMPPIPVKYLNFTCPQPCSRSLDIVDRSQLGQQTKTLIISQSPVSKLHIMITDIPDVENGVFEDLDVLSSLGGGINLLSVKRLYRVHAVALDGDGVPMSYASLSGLKFSVCSSNLVKLEHPKDVGFKAIGGVMVIQCLAEGKYTVRAEIRNFTGTTETPDGVLVSDSLEITAYRETSPVLASILMMPNSGEFHLSMLDGALSRSIPLQTAALETSDETVLQVVTSGQVGVIRAVKPGTCTMTSYIAGGTSSPSKSVTPVTVAMPYSVAVSGPSQILNGKSVVLYAKVSDYGGRPFTPIFVLGSSESATSSYCAFTWSVSGHGVFLEEGERTATVSGAGRARVTMIATSAGAITVALRASCRNLSASGTLELVAPKFAVESLVPSSVFGSHFSDPIILSPNSTYESLVGVVEPIASSDVGLLTVDGTSGQTTLKTESKTGHVLLKTADSYVTHVQVHEVNQLHVHSYGVQSSEISVLKSGKKELTVQLKTRDGRRILPPVDLRLKYMLSNSSLFRVTLSGHSIHVAANSADGCSSLMVLLDENDEQFTGTNMVVDTIRLCVVNALTPQDALVLKGSTVRFLAGDSRTFSVQMRGAPLAHAYTSMEHQDTLQYYQDAILSRMDALMSDLKSDLSRGLINVFRDIGLEESGCVDSLEMHQPYLEASQYVNGLKPLYVFPFSICREVDSATFTAKLTAFLQELGRSADSVFSMMEGGVSAISDNATSGTGVMGMLPSTKSGQNATSGEGVNAAQPSAVTGNWTVDEPDILSVSDSQGVALAAGSTVVKYSSEYMKGDSRITVFEAVTKVEYQHLADSAVRANATNMKPVFGTTIAYKEFYEPFYVVFKAATAGGSYLHNTLQVDSRVFAVCELVSKETWVKEVFGSEATYVVGSSATEFLPACRISIRSFGGKTEWNKMRNVLKGASESAYGLKLKVALYSTLPSDHKPPALTPSKQQSKKSTATDAAAAQPLWVSLRKVDALLSEQSFDWKLPVFAQFVDSVGIAISDVSVEPGKAVAISVYPHYSRCKLRVDGSHYKLRITEHQGLLCSFALENDGIVEPSSVQLVCQRTVAATLKISHPSVARLEVPTSVVTTEVRTTYGVDWMLIVFTACLAAGLAYLIYTLLHRPDIRYYETTEPIKIERRLPNVFEKLYQTDYHGSTSSTSVQYQHRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6E4</accession>
    <name>A0A061D6E4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartyl protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0108020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766690.1">
        <property type="nucleotide sequence ID" value="XM_012911236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6E4"/>
    <dbReference type="STRING" id="5866.A0A061D6E4"/>
    <dbReference type="GeneID" id="24563045"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108020"/>
    <dbReference type="OMA" id="MPHYYTV"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596012" evidence="8">
        <location>
            <begin position="17"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="190"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="531" mass="58102" checksum="EE701784C1CB2D59" modified="2014-09-03" version="1">MARASFLLAIVWQVCALFSGRLALGSQVGSRETQQAFAAPAGPASGNAPPETIYSGPPPKRIVPLIPIQRDVSRTERLSNEVSIRSLSPESHLVKVHTSNWDNVAAGEVHHVFAGRGPNGSLGVDDETARRHADRNARNCGSIPISEATPASSDHVDGGVSDGVTRHEAIFPRAPGNACLSIGSLRHTVLVIEASIGSPEQRFLPMLDTGSTNVWVVHEACESDGCRGSMKYDPRKSSTFHSAPDQKSYVRAKFVSGEVLGELGFEDFTIGGVTVHSQPFAMLRRIPDVTTNDVLRATHFHGMIGLAFPDLMIVKSEPLYERYLRALDAASIFSFYYSLDGHHSAVLLGGAADDLHKGHIRMIPVVTGYYWQVELREVWLGERKVCCDGAAYAIFDTGTAFNSMPYDSFVQLMDLYLSLDSESESGQRLHDFPIIRYVFGNGVEASLRPDQYSFVSGGVYRPAYMQINVNVADGPAYILGSVGFMPHYYTVFQGGSRPMVGRRFLGGNRANGSRERRHIHLRTRQQCCLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6K0</accession>
    <name>A0A061D6K0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766755.1">
        <property type="nucleotide sequence ID" value="XM_012911301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6K0"/>
    <dbReference type="STRING" id="5866.A0A061D6K0"/>
    <dbReference type="GeneID" id="24563110"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108670"/>
    <dbReference type="OMA" id="YEIATYE"/>
    <dbReference type="OrthoDB" id="332663at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="706" mass="78514" checksum="E843D52F4897B24C" modified="2014-09-03" version="1">MMRRASVGDAPSGAFLATASLDDIVAHSLEYEPEKDVSDLKDSENVSLVYHFLRHIWTSMTDASVYEPREGLAGDSDVIPFLHSDEWRQRVSKRILDLLSHFREDPSEDGTGGGEQTLPALRNVAQGHLTTCFKILSSYLLVGCQSSVTCTPRQSRRVGKSVLPKFSSAAMCLVDVYMYMVPIAIDLSSFLDLLTDLVKGLPVESAKVLSDFLYCRVSFLRTSFEQLEASATNARLVQTAGAKMIGLVRVLEGVLGESADGDVPVHIFNLRLTLTSCLPISHLGVCNRQSLSQEFTPVSKVTADEWTDIVTMSLRKRSYGISQFEISNYEAVAAISAPPSSTSGQLFDLKSLAGRGEPRVEVADTSQRIPSYAVYVHYCDVLNFVFNPFIIVEETQDYMDDLQTAFAAVTGYIISLIEKPQPPDTSLSWIIPLTSSVPAFIARSTSVKFWTSFLCASSFALQSLKISHKRTAPTESVYSLLREKSAASLDAIEKTLNQCISKIGGLAVTLERLLCREKEWVLWKQRGCTTDVLEPVTGDVFTFPEDVPSSDGESEEGEMVDFLDVLSQLESVSPVDENGLPEVGANFIIDVKDLCLNRQATAWYLEKRATDKPASSAHEKLYQMLDDYMEKMRMDADPAQGIEEAERSKHDPLFRFRFNRLFANRYVHKYMDLSNEDVTSGSIDCLVESLRSYDRMGKKVRKRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6N1</accession>
    <name>A0A061D6N1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766790.1">
        <property type="nucleotide sequence ID" value="XM_012911336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6N1"/>
    <dbReference type="GeneID" id="24563145"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109020"/>
    <dbReference type="OMA" id="PRVERWP"/>
    <dbReference type="OrthoDB" id="366179at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="159" mass="17645" checksum="0B2F1B5E1D41118C" modified="2014-09-03" version="1">MSRSTNSLIAEQCYLINRDTPRPQNQKRRIHNILSNQISSLNNSDSLVLNEQASEQPPSEETSYARAEGARRPATRPQKRPSAAQNKSSNNSFIQLLTGDAVSDAATAMSAQSRLRQQIAQTHVMKCLGGFKYLEGNAFDNFVVATLPRFDAQNNFKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Q5</accession>
    <name>A0A061D6Q5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA box binding protein associated factor (TAF) histone-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0302750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768557.1">
        <property type="nucleotide sequence ID" value="XM_012913103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Q5"/>
    <dbReference type="STRING" id="5866.A0A061D6Q5"/>
    <dbReference type="GeneID" id="24564912"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302750"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="6">
        <location>
            <begin position="320"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="937" mass="106925" checksum="4B7A3DDCAB2D3AAB" modified="2014-09-03" version="1">MRSRLRCIFPQIYRIPADCAEKSIFKVSLQQPTGDLLRQVADSQIHYLSPFDSAAILERIVEKSGQKGISEIRRSPFYRPVVSKITSSVQRYRTELLFYFLVKFYKLHDVSAIKSITGTFVESEAAKTQNLNQLVELLYYAAHHIPKELQAAGKDKENEQVSGDRLETVESHVTVFCESIQQLQSELIPKVEQLHDGTLIYKLITTITRLPKTRHTHTLTELLLDKVKLQIERGGWNHQQLVKAARSILQLWPFDRDILQKVIRALELNEDSLSTSDIRTTLQLLDSIGAQSYSQPYKMESFRTTIIPTEAIMALSKTHPLFQSDKVTLSEEAAALIANTVEFRLKQIIQMAHRFMSKSCRYVDKHPTLMPNDVRDALRTLRMENLDGYTNCYDYRYVISSKLYKGNRVVKRQSTLKNAVDERCWGRQKLSDIVSRDMQKAIPAQPGLTVHWMIVNGIVPALASNMAQCVTDEFNQEAKRQMLQLSLDHVNFLNSEDATKQLDDVEKLASKIKLPTIRTSCRSDDTVEKAIVDSLQRHLGNSIENRPVDKSADDKAIRLQNITIPKVEHILTKEQRFFLKEIKNTIKRASNTMDHQVQLQLRKVLSILKNSPALDHLLPELSLFFVSELERDNTSIEAILMFAEAIAANEKLQIHFHVHQLVVPLLTVILKQDDERDLQSVHRNLCIRRLAAKALGNIATNLRDAKSGLEGIDNYLMNIYKRAVVDENCTLPVLYGAFCGISQLPLAAKRIVFFPIVPLIMPVLYKKHLRAHDKHAKTASKVEEFAFITCQEIVHLSMIMLYESCFEDILECIHDTGIFAISHEAQIMIRDTLEGCAEESVNPEIFLPIYCAILTRCAEVLTPKKDKESKKEANSGLPEIENAELYYMMYLKEKVAEGQDRTAQITKQSKTVARNVAKHSPLDWYIAQPTHALTLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6T7</accession>
    <name>A0A061D6T7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0303150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768597.1">
        <property type="nucleotide sequence ID" value="XM_012913143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6T7"/>
    <dbReference type="STRING" id="5866.A0A061D6T7"/>
    <dbReference type="GeneID" id="24564952"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303150"/>
    <dbReference type="OMA" id="KCINLMK"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="431"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="783" mass="89005" checksum="448AC59B393002F8" modified="2014-09-03" version="1">MELKRAKPRLQVDFRVPLEVPPDSDDCMDHYLGQLKEFTKAVLVGSSGLMYNKSLIMEYVREMVWRRRSHELSAQLDAHLKDTIESMLADIDREIDEGSPENEDNDYRNRRVFDRMEMCWCHLRKALSELIQVCSQLESPANNGGFSIWAVAMSYFQSYLETRQKMKDRLMVAALDRIADYRRGSEVVFCQIRNIVEMFSFVQVYDKFEERLLAETRSHYHQRAAEVLSQNRITQAYYVIRDLMQHEEECCKKYLIKKSVENVLGVLRVQVLLLNAQTLMDRGELKQIIRRKDVQSMAVLLSIYENTEWSVMLHDAIFEASQSIGEDITTRLQEAAKAAAPAKSPELCRSFIAELYEFKSCIDVTVKGTLPASVDMRAKEQALWNKVINANEQVMEAVAIALASYADGAPHEMGAAEFVEDPRGIRFFMHVFRALTKKLNFEVYFRGMLTSRLLYDHGLNQVHSAVVANLKEECGAAYVAKLEALISDHNNSCKIADEFRSAQNEALAKLAGNAFPFSTLVVSKDTCIRAAPKEQPPADDAFQDCEVDGAAPQDTPLEVKVDPGLQVAKQLQDGFIDLYTARYKNRAVEYLPEFGSATLEMELNGACYELKVSACQAYCLLALNQMEQVSLSALRELMGNEYNEPMMREHLAVLNAPSSPVVVFRHPGISFATCTADDRFGLNPAFVPAERVLELQHRRPMFDERAAAESTHNAVEDITPAMEATIVRHLKINLEDSASNVFKVCAAKHPSIDRFYFNKVVDSLTERDFLRFEPQQDKLKYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D789</accession>
    <name>A0A061D789_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768589.1">
        <property type="nucleotide sequence ID" value="XM_012913135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D789"/>
    <dbReference type="GeneID" id="24564944"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303070"/>
    <dbReference type="OMA" id="GRCTSTH"/>
    <dbReference type="OrthoDB" id="365899at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056318">
        <property type="entry name" value="Microp_apicomplexa_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23496">
        <property type="entry name" value="Microp_apicomplexa_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595520" evidence="1">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="111" mass="12545" checksum="600F939E144712ED" modified="2014-09-03" version="1">MRSILLLAHLVGAFIAIHGGSAALRRTSPSMMPYVEPQTANDASTQGGVVIMDTEEGVSRLPFVEVYGGRAYHYKDSKGKHYRQNDFRRRQESLQKTLENLPDAYETIRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J2</accession>
    <name>A0A061D7J2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768857.1">
        <property type="nucleotide sequence ID" value="XM_012913403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7J2"/>
    <dbReference type="GeneID" id="24565212"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305750"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28920" checksum="900075EDAC54BC8F" modified="2014-09-03" version="1">MVYSSLKGIPRDFREGVDWILALKGSHPDVTLGMLADAVHRLLVRHPVGYTEIPALEKVKSVAQKFFEQKSFKHDPFAEMLLKRYNARMPKDPMGLAKSLKFYLESDYRNVIAAHDVRPQRIAGRLRRVADACERFLNDIKSADSYRSTYTSRATWDVSCAKDPETCAAIFVGIAPMLFTGLLYLMEADEYASRVERNYEVEKQLEDLLRSLGYGKPECKDRIDGPLFTVAVRDINDTILDTLYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J8</accession>
    <name>A0A061D7J8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0211090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768148.1">
        <property type="nucleotide sequence ID" value="XM_012912694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7J8"/>
    <dbReference type="STRING" id="5866.A0A061D7J8"/>
    <dbReference type="GeneID" id="24564503"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211090"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="587" mass="64999" checksum="806B3575AB0096B9" modified="2014-09-03" version="1">MAAYTGKKSYRSAVQSLVIDIGHGYVRGGSAGESQPRCIWPAAVGAGGDHDIFPLVENSNYRHSQVRMLRRVMVNLSGDPLIEIDKNAYLRAIRGTFGDSRVLDRRLLNAAAARPSQVGNGPDVVTMGITTAPRDCWDPFNCRSLSATHRKIFTRLDEVCLERIVSGLNRWNNVSSGMGEQENARPLFLVESNQSSVAVREQQMELVMEQMNSPGIYFGQGSALACYAFGAKSGLVIDVGAATTSLGLVAEEGIFAFREYFVGGDHVDALMYMLLKECDKKTLNAVLHHPSYSLGTALREHMNDDYLPRALATRIWHHEFDPRHFYIQEKLRALKESVIHAASCPIFSADSHADSRYSDITTALMPKKRENASAASSAETVLPDGTPMVIDVYKRRPARHAAKRSKKWMWPPLQPTVDPSEDSRGPPQEGEKRLQNIAADSVMAVASEILFDTAAVAARLPIDVGRFKGIYKSFEEMAIGEGLQNADVFRNLVVVGGCANMPGFTQRLAYDFQHYSQDAQFPVQGVDYRLLNPVVKHNRSVSSWMGASILASLSTFDSSWISADEYREHGKNICRRKGCFNFIQHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7L9</accession>
    <name>A0A061D7L9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA REPLICATION LICENSING FACTOR MCM1 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0200460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767075.1">
        <property type="nucleotide sequence ID" value="XM_012911621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7L9"/>
    <dbReference type="STRING" id="5866.A0A061D7L9"/>
    <dbReference type="GeneID" id="24563430"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200460"/>
    <dbReference type="OMA" id="CECTIVA"/>
    <dbReference type="OrthoDB" id="360773at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF48">
        <property type="entry name" value="DNA HELICASE MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="6">
        <location>
            <begin position="576"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="876"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1100" mass="121888" checksum="DB20E573D1BC16B2" modified="2014-09-03" version="1">MSKITAPRESFPKQNTYRRDASGRQQSAVDAVVEQLYFPGLFLPPLGYREDTASKKGGRICDIVASPVSYYVNGFIQYIVSDDDLLSQYLDMLCVNKYEDPSLLKKLAPCTDYAVTTHHYDLQSSASFYNDGKDIKSSQFLSSGSPSRCDPNATTPRTSYLCGNPPGGTVNGSTPEVAAYRDSECAGNFATNDIIKTEPVYEATTDGRADQNSETCTPKRIPPPAGYSQGTNSRASVGGSADNSRYTISKHYRSVFIDVMKLIVDAPALGSDLMTAPDVLLRLLDLRILPLLYELLEKLIEEGCHPDPVAIVETFHEKYDIESLCKDSQSVSKYLDRTLNDLHCKNTLELPETKRISKNLQFTTRLRNIPPIASVWKNRVDHIREEDVGGLVTLVCTVTRVGIISVLDEEREYRCVRCHQSVLARAVPELHYFIVAPSKCPHYLETTKGAFRPRCFGDTFVQGVAVKRADLQEIRCQSISEDSRINSIGVAIPVVLRRDITGTCVPGDTIHLIGMVKRRWRTLRSGRKCVSQIFVDALNLDVINLHKPPPLNPITTIEDSIYSPFWAKYRKDEVAGRNILLKSICTTMAGVDNAKLGLLLTVIGGFPVHTTPFEEETHVNRWAKFSGDRSFGDTSPQRTSPGLSPTYDSKATRLNRTQCHILFLGHPGTGKSQFLRFAKSLVDRHVSVSGTHCTSAGLTCTVVRDCGHTMLAAGALVLADGGLCCVDEFSLIHPDDKACLHEAMEQQVISVAKVGIKCSLNCRCSVIAASNFKMQMIRRYVNRDDSQGGTHSSHPLLSVDVPIPLLSRFDLVMVFTENPLNDSELVDFLLDTCEAPIRDAKSRALRSLKGTASVPGDSSTCGDYDCEMVDDFDEEDISEEETDEADMATDGTQPRAGSQRNLRKDVKLEETDGERPFNWNANGAMKEYIEYIRAHLFPTLTVAARRVIHAYYVVSRQQALDSGSHGGPTIRTVESLLRLSQAHARLMFRDHVSIFDAVSAIWIGEFGLHGYKVGAYSGQEQLVEREGLFEDIGALLDLFGRQQGSSGSPNDFKMGNGIVSMEMYNFFEKILLERLGLTNVANEAEVKSEANYDSDYDTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T2</accession>
    <name>A0A061D7T2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768789.1">
        <property type="nucleotide sequence ID" value="XM_012913335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7T2"/>
    <dbReference type="GeneID" id="24565144"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305060"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="7491" checksum="8152F6BF2B45C7CE" modified="2014-09-03" version="1">MGSCFCNGGSDCSSKTGCALKFLGIAFAGFIGFSALLVLVLYITGRQYDVSLGTIFGQIRDGFRGSKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7V1</accession>
    <name>A0A061D7V1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0212140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768258.1">
        <property type="nucleotide sequence ID" value="XM_012912804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7V1"/>
    <dbReference type="GeneID" id="24564613"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212140"/>
    <dbReference type="OrthoDB" id="365689at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595880" description="S1-like domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18703" checksum="8E316B89CF1368D4" modified="2014-09-03" version="1">MSRAATARIRLSLLITILAVATAAEAFRASPIAGVRNLQRWRTPVGAASSSVGNIVKGNKILAYGRIVECRGGTSYLVQVENSAATVHCELAGSLYRRRKFMALNTKVKIEVHLLAPKKGRIVDRIDPYEQLVLQRNENKPARPADKEVAKHTDSDTSDTEYDDSDLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7V2</accession>
    <name>A0A061D7V2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768809.1">
        <property type="nucleotide sequence ID" value="XM_012913355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7V2"/>
    <dbReference type="GeneID" id="24565164"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305260"/>
    <dbReference type="OrthoDB" id="347712at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="764" mass="85036" checksum="E4C747379258202D" modified="2014-09-03" version="1">MDGEGNAEPEYYFDVAEQQWWVLQPGGADWEELDNETAESLGLHEAVMQQQCTFVESTLEDYTAAATCIGEAQGTDEPAVDHTQSLLLDPVSMPSIQFGVDSRADSLHKADSSEWLSSCLDDEKPERHENLQVRFSQHTQALSRGYTTGSMGEAGSGSDCDNRVSHGTASSALLNDRLSSLLTSTANMSLHPRPESGGVPARGESYVRSAVRRATRVDAGLSDCIRAVAAERERMRTLTSTQVTEATPGERYQKMIDRARTLAMFSQEQEPEQEQPQEKAPDEHRESMLRELRLEVTGGEPTADPAFGASSDSESEPKLAPYDSLQSLMSQRLSLRRTMSRPYEEGVVLERMFQLLKRNRCATCLVRKPTHVDPDRDELLCASCVRRCPYAAKVGDDHIPMAVVERLEAAYSRSSRGKNDTESKSEKKKHSSHRRKRSPSPRRTYASPSVSVERPKYSHHRKQWNSSASVSTEGSVYDRTPTRSKHRSSHRGRHASVSSGSVTPRGVSSARRVEDDLFVGAPSGWDDFDSRPARMPGRKSYDHPPAEPRRIEEARHASSRHHNPAARAPDMRAPRPQVDPYGYELPVTDDMPGMMGIMANRSTARDVGRMMRPADDHFNRPREIVDRPEYYGEAYDARYMPHRTSRPEYDGGEGDRKPPMDYGMHANPYAPRNKAYNGANYDYNPPRNDYAAPPPRPVGSNPFAQGANGGADRFDMSSLRLALAPSAPNPAREPRATNGRFDAVPPQPSGVAVYGGLYGRRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7V8</accession>
    <name>A0A061D7V8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0201560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767185.1">
        <property type="nucleotide sequence ID" value="XM_012911731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7V8"/>
    <dbReference type="STRING" id="5866.A0A061D7V8"/>
    <dbReference type="GeneID" id="24563540"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201560"/>
    <dbReference type="OMA" id="YNPWSAT"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="400"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="653" mass="72296" checksum="52D912B134141646" modified="2014-09-03" version="1">MAYVQQIGWYNLSVPPSLQLVTYRNTYLFNVGENSQREDWLHLPDRRELFDSRRTDGDSSGSRTDVYRDPANIWTASDQGACGSHQGAILHKVGWLLELRHDPDSATLEVYAHEITETTFVELAREDGVAVYGASYRGDTDYGTFHVVDSVVNLNVAYVIAFDNESGPFLPHEARRLGVTKGSDFGLLKKGQAVQVADGSWVHPQQVIGSPLRGRKSLIMHSNGPASLDNVDKARDLVGRLDYVFWMNTTDSEDLVAGKAPPLDETRKHVALTKAHYLNSVHATFAPQLFPTPPNPQDKFFGFAVDEEGQENQPKQSTFLRPLTKIVMYPAHKATVVEDFACCGYSQELFDKDDVPMMDSLDDNLLSDPSITFLGTGCAAPGPIRNVSGILLRLSKACAVILDAGVGTLQQIYLCSSTMGEFVETISAIRAIVVSHSHGDHYVGVCSLLAYRYKYGKMCKVNDRPTVFAPARILQWMEFYKNNVSPIDYDGIETVIGGKHTVPVCNSGMQFNFFAVDHISDSVGVRLTHEAIGSVVYSGDTRPCDSLIEAAMDCDVLIQEASFNDSDQAQATNRYHTTFSEAIDIGERCRARATILTHFSQRYKSIELGVEPRNDLIVAYDLMRIPIKAISTVAEPMLIATEELNLVLNQISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D833</accession>
    <name>A0A061D833_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonylcarbamoyladenosine tRNA methylthiotransferase</fullName>
            <ecNumber evidence="4">2.8.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">tRNA-t(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0307250</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769007.1">
        <property type="nucleotide sequence ID" value="XM_012913553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D833"/>
    <dbReference type="STRING" id="5866.A0A061D833"/>
    <dbReference type="GeneID" id="24565362"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307250"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="1730074at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="18">
        <location>
            <begin position="226"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="357"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="17">
        <location>
            <begin position="588"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR96821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="653" mass="72381" checksum="CEC66B591A99F769" modified="2014-09-03" version="1">MSQSRFRLSGPLVGAGIVGVLAASYIAYYLYRQLRKRRFMRYLKRIYNNDHELYDEAEDEYSDEDDFYIDERTIDSQRLTSRADLESIHGSGRSRSRYPYGGLTRRTKGVEEFEQEDNIENLGGSAKTRVPRSHFYGSFKSRLAKASGKRDDADDDDDWVNVDDECSRSPSRKSDQVEAADEAADSGADSLSDEDAEAKSAGIDASCLVEAAGSAPAAGSALPGRQRVYFKSFGCAHNMSDAEYMKGLLSEYGYTICDTVDSANVAVINSCTVKGPSQDAMTTEIVRARKLGIPVVVGGCVSQADRSLGVFQDPGVSLLGVQQIEEIVGVVEQALHNRKVTLLDRKALPSLNLPKIRQNKLIEIIPLSTGCLGACTFCKTKQARGVLGSYSLEAILDRVESVVAEGIQQIWLTSEDTGAYGIDLGTDIVTLLRGITALLPPNVMLRLGMSNPPYIKRHIAGIVEILRHPNVFEFLHLPVQSGSDRVLDLMNREYHIEDFEYLVDCVRKELPECTIATDIICGFPTETDEDHRQTLDLIDRLKLPVVNISQFYPRPGTPAAKMKPHGNKVKKTRTREVTQLFMSYERNSVYVGRTLSVWFSDVDNQRGHTVGHTKTYVKVVVPLDPDLVGRKALVTIEESSKWHLKGTVSSLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D838</accession>
    <name>A0A061D838_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767275.1">
        <property type="nucleotide sequence ID" value="XM_012911821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D838"/>
    <dbReference type="STRING" id="5866.A0A061D838"/>
    <dbReference type="GeneID" id="24563630"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202460"/>
    <dbReference type="OMA" id="NDIFTQK"/>
    <dbReference type="OrthoDB" id="361067at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="368"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="473" mass="52124" checksum="C54FAAC3E4D03A15" modified="2014-09-03" version="1">MDGFIALESAEDLLIQKLHRAAVAAGQPCTLISLKTLRKLPPEADAAKFVLKLVADLVEQLAEKTQAVLLLDEFDVWGPIKRIKAAEEEGDSSDFYSANKLPQGGASSQNGHSNDASTGSWGHDVVHERGVDEKIAKTKLSWVYRVLYLLKHSLSCRLLNDGRRLVCIAIYAHPTATKSFFGDIFHHTYEGVKFIRELGYLKLGLAISLPTEEETDECSKVIETGQHTDDTGDCVLNAHLRVKPISHNKNGVTVNTDALQRDIPFNVSCGQIVLSRITLICGEQASGKTTLLNAIFRAWVQGEAIGFSDTANCEPGATEIKYAAGNQWKDYIYPDAEGSYVQSKDALDRNSEQKLDKKRSGEVIRSAYKLEYYNIVSQYVGCGESYLRSTFQRARNNRPALVVIDQVELLFQNSDPDNEDRQGFSTLARTLINELHALDGGVAFVAATSGNVAPEQLPSALKTLPHNCIVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D861</accession>
    <name>A0A061D861_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin, N-terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767295.1">
        <property type="nucleotide sequence ID" value="XM_012911841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D861"/>
    <dbReference type="STRING" id="5866.A0A061D861"/>
    <dbReference type="GeneID" id="24563650"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202660"/>
    <dbReference type="OMA" id="VRCSNEC"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="469" mass="51915" checksum="3919DBDD15BDB7D2" modified="2014-09-03" version="1">MNAVQDQFVARATDDTFIRMLSNVLVRIVSENESKKGVVTRFHSMNAPSISIADYVSRIARHVRCSNECFVLALVYIERITRMHKNFAVSILNVHRLIITAVMLAAKFSDDVYYSNKFYAQVGGVNVTEINLLEAQFLTMLNFQLYVSALEYESCRMGVEKANLFGPLSSNIWGVAWYNATAKRSSRHNKAPASIPAQGGMPMVHYGGGSQFTNVARSTRYADGMAVDNEENVSLNRPYEDIQYTPHYERGGSNPGVHYCVPTQDTAMAGIPMRRAPHCPRAMDDRPRQPTGPSAGYHVLSNVHMPQILPSQHVDTSRIDTPGGHPIPMHPKGGGVCGGHGGHRQVARFTSAPPCCKHYAGSDAVPRRPPRAMLNRMCTQHVDYVGYPHSQWATVKRAAPADSGPAFSPMGSMESTDACANFMNALVARHRDSMKGKCAPRADTWSYEDTRQLCRSRNFMRCGKIKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M2</accession>
    <name>A0A061D8M2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14p/L23e, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0307770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769059.1">
        <property type="nucleotide sequence ID" value="XM_012913605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M2"/>
    <dbReference type="STRING" id="5866.A0A061D8M2"/>
    <dbReference type="GeneID" id="24565414"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307770"/>
    <dbReference type="OMA" id="AMESVYF"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="143" mass="15496" checksum="D12A5DB7F2238D7F" modified="2014-09-03" version="1">MKRGNSRRSEIHSLQDVEVPVATSSALPWVYPWGPSSTAATTAEARTSTSSPLRLPSAAVGDMVLATVKKGKPDLRKKVHPAVIVRQRKAWRRREGYFIYFEDNAGVIVNPKGEMKGSAITGPVAKECAELWPKISAAAPSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8T1</accession>
    <name>A0A061D8T1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="1 6">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0302710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="1 6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768553.1">
        <property type="nucleotide sequence ID" value="XM_012913099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8T1"/>
    <dbReference type="STRING" id="5866.A0A061D8T1"/>
    <dbReference type="GeneID" id="24564908"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302710"/>
    <dbReference type="OMA" id="ESFFEPC"/>
    <dbReference type="OrthoDB" id="364694at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="583" mass="65319" checksum="750F4B6FFD525319" modified="2014-09-03" version="1">MLYHDQFCRFMQEGCSNVTESCTPKRACCLIDRTVAKRLRTHLSQLLDSDKCCRCADNKQCGASDGLRHAEHVCANKCQVNVYNGDVVHKKRIYHIKELALKTSVEVDPASIRVLNRTDGFCDTGKYELAILEEDLFYLDACLSLGSTLVQAAISNYSNISVEMKPKCGILNFNGVPSLFQLCQPYKARIRYQNIVPTKATLKNGHISGIERNRHAKSMYSPIKFFSMKLEDVARELQLLALTPQNNIRVFVNSVEVDPAILLTNSHALNSVARCLVENKMTMARILKLQALASGQQFVANVIYSLTGLVTRLAGKKNSVRRKYAGGIKTSTITNNLMLTSKELLGSIFCNHDDAYKIQKMFNLIGRGLICSLCNMLKTLLSKSHVSVPCARRNLSVDRFNVARCGRGGVTRPYDTHKLNRTLAVQSQGRLFKRHSCKDQAVPLVTFNELEWMLRTIDRSTNPVMATSHTYIATQKDHEVQGTEGCNLALSNQKGVTSEPNVDDRLAKKCAMLLEAAGRWIELYLGGRTSMDLSVVLNVLFECNGGDGRKGPNFFRFSLIDLDLKPAHRIPRWKDDICFLMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8T2</accession>
    <name>A0A061D8T2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767475.1">
        <property type="nucleotide sequence ID" value="XM_012912021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8T2"/>
    <dbReference type="GeneID" id="24563830"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204470"/>
    <dbReference type="OMA" id="FAHTRIE"/>
    <dbReference type="OrthoDB" id="365362at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="862" mass="96722" checksum="7A140054020BE9FA" modified="2014-09-03" version="1">MGWFIDRHLYYLHSEEYVSFLTLIHLCCMVLTGYGVVHHSADLNEIQNNVWAICLSSFGFLCNLCAIRGGPNFFYWYLPLTVLLSLALFFILSAYHGLLMVYMVHLPLVSFTLTGVPCILMVAVSMGALVLGIAFHTVLVSALYSEFHGHSSGGFMRNVTAWLRPPTARGFTIVMLDAYIVLIQIVIGIFCYQRYVKLGQLIAAYRLNPARYLGSFSSIDELEDDFLPPENPSADNSATPVKKLSIPMHHCPPEEAESAQNSDADWSKFEQSNLMHGKRRVSVEHIEPLHFQNLIRHGPPHVISESDGANQSSPFNMDLEEIRKHYKPKPGGYIESLLQSHYAGDGSRKKVTLNRTEPAAGGSPVESTPTASQKTRNVTWEKRDSTQSNEIPVVEEDKTDTVIPEQEGREYSTVRSAESATKHRLSFQSSKTTFASGSVDGEQENRSYVITALKTLRQFSLSSHGAITPDNGVVFGRKNDSKSWRNSYDELRSMTRSLQLDPALSYGAEKSLANCQVDGMRIGSFEGAGYTQRTHRVPHEAVRFQDGHARVLSPINLRTSACLSQMSWSHSDASFAHPTTSNATLNALIRVMPNCGYRVIVAAIRMVHRMSNIRELIAHYTWTQPPNMPGINGVGFFAHTRIESWYVDWMHEFNMTFYKCTINETMLIFVLAMLSDILVVVRLYNTLEVGPAADDFFSTLRIVLLTLRYVAYPAGMMFSLCHLKAKGVTKNAVFYNRSLVMLCLGNMILTFIDLWSCLDIFKAGFALHNSLYACSAMTTTSLMLFTRPPILLGLFGISVFSYGCLLYLAGNTVGWCILELVSQLVVAAGCLMFFVRPIDTNRRKLFCLYTLPYLFYLEAMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8V2</accession>
    <name>A0A061D8V2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767485.1">
        <property type="nucleotide sequence ID" value="XM_012912031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8V2"/>
    <dbReference type="GeneID" id="24563840"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204570"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="101" mass="11351" checksum="578A724026135509" modified="2014-09-03" version="1">MGKHDVTHNGILCTRNETKMCEIELVTEVSGIGSKTICSNVMTMRKLNLVHKSVCKDLEGYLVNWLAVFWGGPNAPNRCLQRHDTDNQILSMEMIAGVYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9H6</accession>
    <name>A0A061D9H6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0312190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769502.1">
        <property type="nucleotide sequence ID" value="XM_012914048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9H6"/>
    <dbReference type="STRING" id="5866.A0A061D9H6"/>
    <dbReference type="GeneID" id="24565857"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312190"/>
    <dbReference type="OMA" id="KYANCTA"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="151"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="349"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="644" mass="70281" checksum="D4B285BD0F079599" modified="2014-09-03" version="1">MKRVNTPEAESDDDQGLSLEFEDGFFDFLGDSSTGVGRDGHVSAPRSRSAAAGVAAGDEATAESLTGDKATARQTASGKVAADEPSPNAADGAATAAKGADSKADPAMRKHLTSTSNWSDFGIARSLIKVPSTAVFDMGYEAPSIIQSKVIPVALEGKDLLATAETGSGKSAAFLIPTLQRLINAGVIRQDSGQRTPWHAQRVGTKALILLPTRELAAQCFDVFLGLTKYVSQNGMLLTGGVPVKDQEARLRRVPYIVFATPGKVLDIMLNSNSIHMDGIEIVVLDEADRLLDLGFKDELTQILKLCNKDRQTMLFSATLTEATKEMVPVSLVNPIYIQAAPRITVAKTLKCEMIQLPNDELREAAALYLCKQKYTSRTILFFQTKKAAHRAAVAFGLAGLKCGELHGDLSQSKRFEQVEMFKDGRVNFLMASELASRGLDIPGVRAVINVHVPTDVVRFVHRVGRTARMGESGTAITFYVESERSAVKSMMKRVAAEGSGLEKQKIKLSTAALNNYKRKIEELEDKIKEVLMGEQVEKEMRRCENVIKHGSEQGKEGNLREAATQRVSEKRMWFRTKREKRAASKKELVETRLRAGLETERDPESPPRAPKKAVKRGVNPRNPPKKGAAGKGSRAGRHRAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9J2</accession>
    <name>A0A061D9J2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0312390</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769522.1">
        <property type="nucleotide sequence ID" value="XM_012914068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9J2"/>
    <dbReference type="STRING" id="5866.A0A061D9J2"/>
    <dbReference type="GeneID" id="24565877"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312390"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000386">
        <property type="entry name" value="Fibrillarin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR97336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="285" mass="30942" checksum="6F9D94BE26177AAF" modified="2014-09-03" version="1">MLGKRGFKPARGGGGRPSGKPMRGRGFKGGRGGGPGGKRGPGGGSANKVMVVPHRFSGVYIAKGKADALVTRNMVPGESIYGEKRIQTMNEESEPTEYRVWNPFRSKLGATIIGGVANMPIEIGSKVLYLGAANGTTVSHVSDMVGPTGMVYAVEFSHRSARDLTNMAKRRPNIVPIVEDARQPLRYRMLVGMVDVVFADVAQPDQARIVAINAYHFLKPGGWFIIAIKANCVDSTAKPEAVFAAEVDKLRKENCKPREQLTLEPYHRDHAVVIGQYRVKKKKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L1</accession>
    <name>A0A061D9L1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0312640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769547.1">
        <property type="nucleotide sequence ID" value="XM_012914093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L1"/>
    <dbReference type="STRING" id="5866.A0A061D9L1"/>
    <dbReference type="GeneID" id="24565902"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312640"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="443" mass="47730" checksum="005E4EAE6E80112E" modified="2014-09-03" version="1">MEHDKENAPVAAEIQAELENGTRPEFDLDDTSFMLPTTIDRAGLSRMINDLLGLEKPVAFDIFFRDEPLRTTLAEKLEKHNVESETTIKLVYTLAVTEPEEEEVDMLDDWISGIAFTGHLGRFATSCFDGNVSVYGADGNEKVHEFVTPDKSATAVALHSSSALGEHLEIVCGHINGLLEVYCLETRGKKANRNLVATSHSDHDTIQAIAIDEHGTLMAAAGGSGNILVYDNVGCVTSLRHKLCRAIEGDTIEPVSTLVKHTKTVTALKFVELTEPVLISASIDGSIALWDARGATALATYGCSRAITCFDFNAAHAEIYTGYNDGTVAVWELRGKGDGASPKAPADVTNCNLTLRMSTAMFGRAATAIKVNPENPNLLSAVALDGTAVLLDRRSIKIPLQTASFASHGEPDRCTGTCWISAQVMTCTTAEGQIRQLTFKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9T7</accession>
    <name>A0A061D9T7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, C3HC4 type domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0107980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766686.1">
        <property type="nucleotide sequence ID" value="XM_012911232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9T7"/>
    <dbReference type="STRING" id="5866.A0A061D9T7"/>
    <dbReference type="GeneID" id="24563041"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107980"/>
    <dbReference type="OMA" id="IIYWNDC"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="294" mass="34130" checksum="B7AF0096F44B0B9D" modified="2014-09-03" version="1">MAFAGLHGQQHYGRDLADGLRFRSALFNRIADFFIGVDTYRQRRARQRANEADMVMDFVVLHPLKALTFIKGSIICGALMNVLLYVPNETVLGLVEPQSDLGDSIVWWWLAFNKLLHALQIPGRIMALYTMSRLWGRSNQEIMYCMSVLTTSRLWNWCRRLSVLTYASYAAGFLASRHPRVQDHVLLNGFILYVFSIVTMRVAFTFAIFYHCFPPTPARNTHKPANREEIDRLPVVLYRDMKEDNATMCRICLEEFQPEHRLRMLRCKHGYHVACIDAWLARSNKCPWCMSTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9W8</accession>
    <name>A0A061D9W8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">REGULATOR OF CHROMOSOME CONDENSATION, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766726.1">
        <property type="nucleotide sequence ID" value="XM_012911272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9W8"/>
    <dbReference type="STRING" id="5866.A0A061D9W8"/>
    <dbReference type="GeneID" id="24563081"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108380"/>
    <dbReference type="OMA" id="ELHENNQ"/>
    <dbReference type="OrthoDB" id="293800at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="101"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="249"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="305"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="479" mass="51935" checksum="8AEF028BE7483B9B" modified="2014-09-03" version="1">MAASSNQPAYIWSKSTAYNAVNQVTVEAQPVITTGQIHRVPAYKDLRTVIYIWGDSPAANPADKSHAKADWEPTIYRQLPDIRIASVSCGPSYMMLLSSCHRLFALGRGDYGQLGLGASLRRVTVPTPISDIPTVTEVVCGEYHCVAIASGGSLFTWGRNDVAGHQEGFTTSSPKELVFMGSKTKCRSVSVNQTLTVCACDAGTSLYHWGFSFSGEKIQRPQLFYTFDQARIRQVALGKSFGLAVSDTGTVYGWGDRTYGELLGLGKKHESSYFMLPTLLKLRHVHSVVSVATGDRHALLLDESGKVWSMGENMYGQCGVPPCHHSSLLQIDFSDSSFPVSKIACGPRHSACINSGNQLFTWGNSAGHKLIFTSSVDMLVQQQRQPGVSAYSGLKNCCSHPQLIYALLHEKVACLGLAAGYTVVVTGEGIVPSEELPPTVVLVPDAEEMPSIEGTPRIRETPTNEEGSGEAYFPIQLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA15</accession>
    <name>A0A061DA15_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766776.1">
        <property type="nucleotide sequence ID" value="XM_012911322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA15"/>
    <dbReference type="GeneID" id="24563131"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108880"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="62" mass="6496" checksum="07D57ABDB3B1770C" modified="2014-09-03" version="1">MIPALARGERLTTTYHGSLLSNSVHSVMEGETNCDAMGARASYGLGDGRKSRPQDGTKGAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAF0</accession>
    <name>A0A061DAF0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766891.1">
        <property type="nucleotide sequence ID" value="XM_012911437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAF0"/>
    <dbReference type="GeneID" id="24563246"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110030"/>
    <dbReference type="OMA" id="DYESIFY"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="917" mass="101477" checksum="9C4754F16E722F64" modified="2014-09-03" version="1">MHGSTYGGRITGHVRAADGISPSDAAYGGRFVLKASTSETATTPALPVLDMTEEEHVIASSNLFKLFTRCVNACDSDNFDFAVETIVDYVNAYGKYCSPFFKEPVEVTAPAPGSDASDEGPESSVDESNADAEDEAFEHKKIPPISDRSLSYHYTSEEVGIDVDGAQRRWRVAIKPNVSRTVRRLIIQHRKLCAGIIGRAMHKVSSLDDLRAITTVSRDAARLGIVVLKGMYAAMCVIHAKLGRAEKAFKYLERMWALGDRRRHRSYEPLFEYFEEHLDGDGMLRVLRHLVEVGGMPVSGLIFTRILVTIGLSAKHRLLELGHSNPVEDRASAHGPSRPGLPADQATSLGSNNRISATANMKSDKQRDALSEVYGTLRRQLTEALEIFHKHSCNRVSLSSRLGYVVSTVLSDVVPGLVHYTHVSPADSSTLSTSGTAVLTNSFSDHGGAGNKIPHSHAPPDAESHGVCAKCKRHLPLIQLSVEDRLTVFRSWLQNIYDYNFPEIIRLANFYAWLHAPMRNGVGYTCILDGQNIGYHRRQDLSPLDFYKIDTVLREMVRRGERPLVVLPHYARANSPAACDVLEPETIDLLFPGHKLPRKPITLSSATPSRPKRYSAAEIDVINRWTDSKQVYFCKVGSYDDNYFLLANVMTGCAEELAVLGGFLKSSLNLSLAQRNETGASVLAADLPDPKVEDYVHAVDPAMRRPMMITVTNDSLANLEIPGVEERLMRALRDIPLSPYFFTSDEGWHGGAYTGSTASGYGGNAVIGQRLKYSLEMYSSGRGVYHIPLGYERKVIDYRARHTVLVTRNERPRIDPPAAGVFLDTPGPSARKGEHNIDAELVQVQAWLDKHGYTELLQRLGPRMPERNTRLRHPRGYAITTRTPEAMKQKFNPSQQTRWLCVDLSAIDNVAASAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAF8</accession>
    <name>A0A061DAF8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0308650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769148.1">
        <property type="nucleotide sequence ID" value="XM_012913694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAF8"/>
    <dbReference type="STRING" id="5866.A0A061DAF8"/>
    <dbReference type="GeneID" id="24565503"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308650"/>
    <dbReference type="OMA" id="ENEFTNG"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="271"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="514" mass="59514" checksum="BEA8E56AE97D9023" modified="2014-09-03" version="1">MGVNVEECTPYDITSRISPFLDVEMLLHVLDWLEQKGVYKGELSAVRADITSKVASQRLTDEQFSEQEAAMLNTLAPLQEALEIYKKSQATRISSSAERIWLVSLPQWLATQGTTDIEVSPESEATIFKLAKLYSDNGDWKKCKQWLVYYLENVAKYTFDGNTAANRAKCYWGILRSITVGVLLPSTEEELLVMATTATPYDENKENSVLEPDLPRTGVQCILRLAEIFNNEELGKNRKDLVLKRCWLLHWALFYVFRYHIPLSQVKSKNAKSYEWPHVQEYLMDDRNMAVVLMVAPHLLRYYAVYAILNRNRKDHFKVISASLSIGKAKYSDTFTALVSALFVEYNFEDAQKHIMQIQNACHVDILLEPLKFQIEEYSRHIIFETYCRIHQSINLDLIAQKVNMSSLEAERWIVNLIRHSHLEAKIDSEKNCVEISTVPPNLYQQVIDKTQNLTMRSNMILQNLMNADAGITQYVRGQDDRGLKRSGQQQRRQQNHRFQSFGQRDFFRNTDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM4</accession>
    <name>A0A061DAM4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766951.1">
        <property type="nucleotide sequence ID" value="XM_012911497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAM4"/>
    <dbReference type="GeneID" id="24563306"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110630"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="292" mass="31054" checksum="477B37767C3B9BAC" modified="2014-09-03" version="1">MSQLGVSYRNGDDIDWQKCLGNRRCRNGTTQRNPLKSIVNSKLVEGDDVGGLDQTDDLVVAVGVRVVVRLVVSATLLLHAALLLLSLSETELLNQVGDLVGVDDVVQDGARHLQLLDTVGERDLGRGLTPRHTLNLDVLDQTQHLVEVGLHAGGLDVDDQRRLGGLALLALACLHSLHLLLHGVILVFVIVTEQVDVVGLLLLHGEGSLGEVSGGILGPGADVTEPPVDVCELRSARGVAELAEHSEIVGGGSLATGHEAVVGKVFVQLDEALAASDFAKVNLEVRHCVWQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAS8</accession>
    <name>A0A061DAS8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769283.1">
        <property type="nucleotide sequence ID" value="XM_012913829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAS8"/>
    <dbReference type="GeneID" id="24565638"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310000"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="350" mass="37015" checksum="DB4D38F4AB5D660F" modified="2014-09-03" version="1">MCKLQEVEKAKEKGAQKGRAADKAEDGPPEPQAEKSKDESDVESEDEDDEQLLDEEDPPARKTEVTKIETAKPVVTKAEAAKPTATKSEATKPSTLKAEATPNQGKKSEGAQNQGKKAEGTTNQPGGQSDGNGSSAGTPSPGDPVPSSGQDLGEQRSTSGSAQKSGDPSSDVPPPSQGVAGVGGGGGSGGPENSGKSNTCPDGTTSSSYLGDGAICFSKSNDDEEIIWNAQRQSMLEDHYKNEAKTLVRMQTQQQRNHPPTQSRYTSILPNKPSLHASRPPPQQIVGRPLNENPYNAPQERDADHWDGSAIFLDGRSFTNPVTSQIAMEKAYEAEQKNTLTNGEPIGMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAW5</accession>
    <name>A0A061DAW5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769982.1">
        <property type="nucleotide sequence ID" value="XM_012914528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAW5"/>
    <dbReference type="STRING" id="5866.A0A061DAW5"/>
    <dbReference type="GeneID" id="24566337"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402840"/>
    <dbReference type="OMA" id="VFGHPRY"/>
    <dbReference type="OrthoDB" id="384245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056324">
        <property type="entry name" value="Microp_apicomplexa_19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23533">
        <property type="entry name" value="Microp_apicomplexa_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microprotein" evidence="1">
        <location>
            <begin position="110"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="205" mass="22706" checksum="0A0D8930F750F3C6" modified="2014-09-03" version="1">MLILGNKHRQGIKLEALTGGYSQAVTKATPELISDATRNYDLILCLDPVLYARHLYNINLPCVAICEVDELYKHRDIPDAFDYFIPIGPHTKESLLDIIAARGAKMLTGVDFERSKRTETSDPVVENIFLTGKAWEFLTHKVFEGEAGSSFLMAAGAVAIAVLAGRERRAGVLARSLQMGPASSLRVFGHPKYREHIPRNPLMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAY1</accession>
    <name>A0A061DAY1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767061.1">
        <property type="nucleotide sequence ID" value="XM_012911607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAY1"/>
    <dbReference type="GeneID" id="24563416"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200320"/>
    <dbReference type="OMA" id="FKHRITR"/>
    <dbReference type="OrthoDB" id="364411at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="304" mass="34365" checksum="F3966F52E34D9419" modified="2014-09-03" version="1">MENNHNSIPIDDCSDLITRAFVPNKMSPYARVSSHYCCPKTQSMFDDPIGLNDESISLANSARSAFSSMDSVATTHIENGFSCIWAEQEGVTTPQHLALSSQTEDPDVRLLKVIKTLFTQGIVDVFRKYIDEIVKKDVKTMIVQKDTGKIHLDINSIRARVFAVLRKCLIHNTEVNVVHIFEAIREKYTTTLTDDIPSFGSITHSNGYCKPCVFANKAINSCKNGVNCNFCHFKHRITRRKSAAREAQEFPKVGREPCTRRQSWACITPQKLQVYLPHALSTNKPIRQITPAIDNRNIFNFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF5</accession>
    <name>A0A061DBF5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768420.1">
        <property type="nucleotide sequence ID" value="XM_012912966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF5"/>
    <dbReference type="STRING" id="5866.A0A061DBF5"/>
    <dbReference type="GeneID" id="24564775"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301380"/>
    <dbReference type="OrthoDB" id="361408at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1136" mass="128920" checksum="2923F7526B8FFB26" modified="2014-09-03" version="1">MCNLAHNIKLHKSYVSQFLLFTASLILYWFALCSATRIKGQYETRNVLIQVANYNNISRVTENEVDSLRTFYKSILHSVELYKIPFGYKVEEFFLETKTAYNAERIDLLSINDSNTIDLDPKVDVKLILILYNVERRVYGGKNMFACENISDRIYLLHLAPRVELVGAKSQCQDVFRENSEELSDEDTKELTKSAGDEIETVESTSTNHKITGFKWHFVIVTVFTIIVTVVVIIFRFKGVKNLDSIKAVHNTLNAPFKVPTDRLWITEIPASDIVRFRTHIQEQQVQTNVQHVKSLGALSIWLQGVLRSIYTSKWLCLVAKRSGGPMQYMSLGLADIQDITSHFDTIELRVFLIFQNTDSEIIYSQLDFGQTDVGVSNIVGSRVYPLCIKPEIIALFASAFRFILLIIYILFDLKYDNVVGKIPRFFSANLNTKAAICSLSLIFVLEVTNVVTIFLLTFKYMPDAGRILLEGREFNVMVSLLVTASRLEVMSKIAIFLHAVVLVLCFVAFLPQYYFSFNKDGEVIRRPIVINLFAMSVVIYQYGILLVSWSIIGNQLFGHNVERLKNFFAGLRCNTILGFNRFPIYQYNKYHALYNDIAVMVFYNIGLTLIFAIYYYFSKVKRRKEVTIGTLQKLHDNFNVDIVASMDDIVRFKMFVKVVEKHKHYMVENAEIDHCKQFFERFEHHSIMRLNRGMQFISCLERIKKYALCAVFLRMKVRNMSLLIRNVQRRYREQNPHKQNKRGYLSLLKEKLQLTVEEIDEFRRSAEIAIAGKSITRPMKANKLNCDICNNVNCGGHSEKEYIKPGKYDLLELENFLIHQRPTPREDLLPEPCRDSKSTQSHTSSVHVTIPSCKDNVSLGTLSHGKSDEKRENVYSVPSRRESLKSHTTNTVSECSALTYVPLGAAPANDPVLEPNSAGGDTSHHYKGNSRSETHVIKGDGGPSGVQSHRNGATSSTSVAKPQNPQHVSVGAKQKNNEKLHLTEAMDIIHNNNNGDKGSISAECTSKSYDVITGASESDDKNSPPRDGQFTLKSIAETNIRANRVDASSNGKNDTTKMRRTSLNMHPCNSADDALMGSIPNRTQGKEESIATKHATNVLSDSIPNREAKGKMPLTKRSAHINKDKRTGIFKESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH7</accession>
    <name>A0A061DBH7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GINS subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0405450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770247.1">
        <property type="nucleotide sequence ID" value="XM_012914793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBH7"/>
    <dbReference type="GeneID" id="24566602"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405450"/>
    <dbReference type="OrthoDB" id="374114at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="4">
        <location>
            <begin position="53"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR98061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="151" mass="17075" checksum="FEFB24462276A327" modified="2014-09-03" version="1">MSFLCPKAQEESRADDELLPADELELRFFYAKHLYRAGLCKISFPAYYKDAGALLAEATATAVGNLSPLYFQLGYELCDLLPESEWPVDNLRNVLKEAECKRRAYLLRRSETCDDTFLMGLTLSERKLHNVVMHGDSNALITPATSQTFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR1</accession>
    <name>A0A061DBR1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMMECR1 like protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767376.1">
        <property type="nucleotide sequence ID" value="XM_012911922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR1"/>
    <dbReference type="GeneID" id="24563731"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203470"/>
    <dbReference type="OMA" id="TNEAFPL"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="206" mass="23135" checksum="0FBB341258642C20" modified="2014-09-03" version="1">MVTPIDDVIDQVDNTLCAACFDAIYCAINNKLLQWLVEKNVSCPIFVTWMIADHNGNDELRGCIGTLSPVPISQIGHYAKMSAFEDTRFPPISGDELPRLMCGVSLLHTYEAAANPHDWEIGKHGVIVKFEQNGRQYSATYLPEVAEEHNMSREDAVKQLVRKAGYRGALSQELLSSVKVTRYQSKKLKLSFREYASLEHDGESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU6</accession>
    <name>A0A061DBU6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767411.1">
        <property type="nucleotide sequence ID" value="XM_012911957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBU6"/>
    <dbReference type="GeneID" id="24563766"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203830"/>
    <dbReference type="OMA" id="KHAMGRT"/>
    <dbReference type="OrthoDB" id="366219at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="255" mass="26328" checksum="349492F1B39C3195" modified="2014-09-03" version="1">MYPPKNRVSTTGSATRASKTFAGSAAPSPSSSSASIMSSLKKATASKATPSKSSVPAKTAGNSAAKKSKVALTVLPAESEAACSAVEPIVELDPGNLDEHSVKQDQDTAANMELLNCQSFAIQECGRNSAASSDDYPDFTVQDPEPGSKTFLNTLKTLVDITGFRNGDVEPLSRATSGSVEGEGFSIVTPICDATYDLISSSSRFIRGTADDEDDEEPSGTAANDADKGTDASTAAPGKATSNSTWNLQGLSNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW3</accession>
    <name>A0A061DBW3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770254.1">
        <property type="nucleotide sequence ID" value="XM_012914800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBW3"/>
    <dbReference type="STRING" id="5866.A0A061DBW3"/>
    <dbReference type="GeneID" id="24566609"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405530"/>
    <dbReference type="OMA" id="HFDGRHP"/>
    <dbReference type="OrthoDB" id="366259at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1212" mass="136821" checksum="D53E8CC380596B92" modified="2014-09-03" version="1">MLRTYVHPVSKGATFRQKCRFSSIFDVVRQRKLEQSNTVAADNPAPLQKSAVVDDKSRTGRGDESNAHQIWKQFNVLLSKPIGYRNVWQLRYLSARALELLAITRAEELCKITTVLAHMKYRNVVLLQGISEALSWYCKLRNCKISYVTSFLRACATLKFVPSYRHLDVFFAELDKPHQTPSVGDHLRFMQFMVENGLHDGDVFMNFFERCRDKCLNDMGYMDHKHLASFSQTQLIIDPTDSDVFNRICLNFERNCEKGEVAQFLMLSNSMGRCHISELPSHYLRVVGHYLEHPDKWSPKLLITVLHVLKKFYYRDTVALSRIGNITVRNISQFTSEQLCAVLNCYAAMSYKHKELVHGIVRSQFAYEGDKQKTHFSTGLQDVNARLKVLAGIANMLAKVDYKPIAIMKSITESTIHCMQSIIGDTEPATTDKGDGTDEVNLLPNTIPWVIYGSRSLHSGDAAKQIGAGSAPEVLTGSMIVDMLPTTVLNAKGTEEEHNKKRTALRRLLRPENIAYTSTGTSMADLSQLKVLPMSVDVVRQQSLKECMDEFLNLHFDGRHPASRRLNMRKLMQLQSEQLKLRKSFKSSNVLHTVRLEKKRAAKISVSIRKLKRKMRYAGSRHVQMTQYFINECRVLKRCFLRPYTAPIRTEASRSHVAISSGSSSTLPMASDDPRAQQIADAWKRFNRWSVSRPSIAQQYNEDFGNVQISNGHLNCRMDTTDATSQPVGYMAPTAGASDRPPVIPKSQWNVVRHLESFVDRRTPVFVDDALFMKPVRVSSLYSWRLKKKLKALERSHTENAMGDTIRYMYHNGLWRKPQKEMDVTIPMEQPLWRHLFTIVSSLHKLNFTSFDMINKLTKVMQMATPVNVEQGDRNIVDNRPQELCGVLVATLKGFGYMISSISGIISRDASGELASRLLKTVCNSNIINTVTTLSEQRNARIPLADLTRIMRTFNALVFVKYGRIRVHNIVAKLGRLRNSDDAKTTGSVELSVESGSAICFNRPSWAVMDTYESLVTLARICVSEHGGRFSNCGDTANEGADALIRLLDEVTYIQSMWSMYSSVIPGGETMRKIATVGSDLADALLGCLDKGATRDDVLRGVCAIRRLRLTRDLFVDGETACEDVASNGGDREDSSDHQIRLRKLTVEHRITADEINGAMCAVYAGAFHPPLKLRHDNHLRSGMVAIHTYADPTTAATGILHNYYADHYNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC81</accession>
    <name>A0A061DC81_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767576.1">
        <property type="nucleotide sequence ID" value="XM_012912122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC81"/>
    <dbReference type="GeneID" id="24563931"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205480"/>
    <dbReference type="OrthoDB" id="10407063at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="808" mass="90871" checksum="593BCBA40DD5F997" modified="2014-09-03" version="1">MAYRLRIYNIPCFYITAFVIVSEYLKVSFALRKWERKETSDDAVLDTSALHCEYCDPWSEWSVCNGNNEQFRLRWCVFKRTNAPVMNPNNPMGVPREPLERLQFIEHRPRRHSSPDAAVELSLKHANCTDSLLPLDVCGQKQSATGPVPPFNSTNIGQQRTDVRNDQDTYKDSDVSPKVGHARLETEHKMLQEKSAFNLQQPRCQLELNKMGSDIYTRRELAKTERQEAILRREVTLKRYGDLCAGVLSALDPHILSQIEEDKRRAKVEYDRADNALKQQILNAKVEDERAMANISVNNTPGNAIVDKLRSDIYKQRQYFREEREKLEYNRGVALKRYDDLCAGVLSALDPHILSQIEEDKRRAKVEYDRADNALKQQILNAKVEDERAMTVFNAESRRCAMELGLGHNVKDTSQRDIRVEARLNNNVQKIEEQIDDADTLRPEKRKAVEEGTYDTPNSDNKPHNNTMEGAYSSKKQDQDVSGDLHATSNLAKSEELLVNDGPTKTDTDKFSHDPAKQHPTGPTSVYQRNTVDIYERDDAVHESADESGTLSDGTSNTSKTVMNADLWKTPASVTEKRRIKSTSTDNSAASKNDTQGVPKHGNNSEAQVLAGIAKKVAHFDGPKQRRLVESKKDGNRYIMDLAHDTIITNGKRIGTSQPLHSKWHQRPLIEHAQTGLGASLKENTSIRSPQASANVKSVMSHRSPNHTISQHSKGLTEGKTLPLDTDERKHSDNPYNGGTDSVVLKITPSSTGNADKDINVQTMLAPATAEKFIPKRIYRQTVKMAGAGIAVLLILTAGSAVYIKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC92</accession>
    <name>A0A061DC92_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor S-II (TFIIS)and transcription factor S-II (TFIIS) central domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0205680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767596.1">
        <property type="nucleotide sequence ID" value="XM_012912142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC92"/>
    <dbReference type="STRING" id="5866.A0A061DC92"/>
    <dbReference type="GeneID" id="24563951"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205680"/>
    <dbReference type="OMA" id="SPLEWEN"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="10">
        <location>
            <begin position="131"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="8">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="302" mass="34572" checksum="6C77F17672F42205" modified="2014-09-03" version="1">MEYGQEILKIRQRIEEFVPNILDKAPSEEEVKELLGHLRKLEDVKVDRTLLQNTRIGAALTKLAKSPSKDIDVLKDTAVKLTSKWKDTLRQQGSSKENADDAPLKRQKTEPADGNADSLPKYQYLLHNQDIRDKALVYIFNAFTAVPGSGYDYKKVSKLAYDVECGLFDKYLVNQSNQKEYTLKLKSIAFNLRDPKNATFRNKIYNGDIDANKVAAMESAEMASDEKKMERINILQESLEACQSDWAVKNILMSKDGKKKGQFKCFKCNSSETVYHQLQTRSSDEPMTTFVTCLQCNNRWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM6</accession>
    <name>A0A061DCM6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767846.1">
        <property type="nucleotide sequence ID" value="XM_012912392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM6"/>
    <dbReference type="GeneID" id="24564201"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208140"/>
    <dbReference type="OrthoDB" id="366590at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="27851" checksum="9ABC3BD0AFFBF551" modified="2014-09-03" version="1">MVYQSLTDVPQNLKEGIDWLIALKGDDPQHFLQAMGTALHELLSSYPAGLTRLPALEKIKPTTKKFLQQKELQDQPFVEILLERFHKPLKRDFTTVPMCDGHIVESTNTNVVVARRVTPRSIAKSIGEVVDVAEKFLEGIKETDGYVSVYGEDATWIDSCLEDPEACAVVFVGIAPMLYAGLRTLRKVSAAAVKQGPDSDAAKHLGPIIKALGFDDGVCRDDLSAPAIRNALRGINPRILTIIYDIAGFLAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCU7</accession>
    <name>A0A061DCU7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">-DmX-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770198.1">
        <property type="nucleotide sequence ID" value="XM_012914744.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCU7"/>
    <dbReference type="GeneID" id="24566553"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404970"/>
    <dbReference type="OMA" id="IEPLCFG"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2221" mass="245530" checksum="7D7F2BF7CB61518D" modified="2014-09-03" version="1">MTRKAAHRQEPADLANCTERVYDLLSIASGAEGSSGSDARLAAAILSVENGRECASDSPLEATLYVFQYEHEGSLAKWWTSRRDPRIIGADGGSARLRKAKCAAPEGVRALKHKAHVTNANWNRGCASRGYELLVSITRDMIAYVWRIGASKADCDLIFQVDIGENVFGPSASAFWVDMTSIGVDSIFTGQEFIIFHEVTDGTSRTKEVDNGGPCHAESIKSSGVQSKSEHAGRCSGGDCSVHKQHFKILALQGIHSPSGNVNGEFLISHQDIALPVVVQNIQCVQLCKHTLQTGLITLYSPDTMRPTKVHPANGFQASRWMTLVSRSINGEPCEEVVEGMLGNQIAIALHKFLPPCTIKGVSDLGLPVELLIAPGDIFLKDCSMQGTDNVIGLVVRYLCRAYSPLFIPRMAALDDISSNVNMEEAILSKLNAHVDVVEAESISDPGHFLALVLHRNGSVGLCRASHTNHALISYNKLQIPKVAHVNAMKVLKHNDRVLVAMFLVDSVGVTRCSIYCWNACKLTLDASWPFQLAPDKEKLIMEFGVWYEGGPLYLMTRCLLAGSNATSDNAVHIYLIKGADILHLSAIADNEIRDLFTGIVRKLPLEVRGARYSLRGGTLICSSQAQSTITLRLSTGAKVDGDSLVIYHPRYIKAFVDIGLRRFVDELVCGLVEVCRNFLVKLAEDNACGSTNTLHHPCDCLTTKVKHVQMFTDFDRTTSLRLLQTFSVLVNVDPANLGVEVGVNIPSVDITEGVAAKELLLYLEHMRLPGLIWQDQLELMQLIETQFQNSGAAKFIGNHASHQKPISRMDTLSNFLLMNEAKRYEDFNIDESIDFSLTSDDEKDEDPCDGDRSVSCPLIRKAQHLLQSGKEKEKVQMWRTNDELASLTCPSKILTDDFCIGRCVDYVKYGSDDEDHLVWAILFKDDHHLFSNMIALLDSGDDQELCNYLLQHMKSFGIGYWVRTPTCIEQFCSTLERGFRKLISVTDTGSSVDKFDDFGFWSILRGKPLVYGCVLKAKGFQKLGEFLSNNFSDEKWKQAAVKNAYALIAQKRYLLAAGFFLLADRVGDAVNVCFQYMDNAQLACLICKIRQHDIEDALRLMKPSKVKDILQCNMSSDCVINVDVNTVNDLVYYLYTGIRFKHISEDVMRDTIIRCADGYIDMGMPLMGILINSLNVTDGPNIWKPLVVQSNMQHLVKNDLDNCSLYQDCVQTMLRLCEENINNGDKGVSNNGSEIDNSSAMDASSAANGPANKHSDQSPLSSESNRDCDLELYQDGFYLYLIHLLNNLKGLYGLELTVGSVSGKASLNRNTFETVQHLPDYFSHLCKMCIAFFEGDAAIDGTFMLALMLRAIMEGRDSFSSCIILSVASLLSITCFDRGVNGQIYRAFMGQLVVLNNLLNNQGSGDQFLACLLRTIEPLCFGTPGKTLEPQLINVLHSIETPPKHAFFGICLGTAVLETLMGICRSWFYKFAEHAESAEQALMDRLLYSASKFLFYNVKSEVVEDALNSTGIVFPMLSLRIDLEKPVDCKVKDAECHVYDSFLEQYVASVYGTEFEKLWRLLHCGFRTASIFNRHMHPTYKNGYRSKGTCCRVTEMGEQPQAMTTESKALPLVMPMTAMFAPPQAWSQERVAAEAKLKERNKGDRKNTCEGEVTIFKVLRMLRFKTLHAFKGRLASPSYAMPSTTICEGAKGLTAKAIVGPVISDLHMMAMLNLRGPCTLSALPDELSQGALSEIFEAVNKSKPMPLHYSLYVKLMRIMTMYSKNRLEKKYAVKVSKFAALAEKFHKCFNARNNSKDPSLGGPSGGICGHPFWPIYAVVYGENPPKHMPAYNVSLQHPVTLMRTANTGLDSAGCASDRTIVYDCVTDMHLNRGKGSVFGDLCSVAWSADSLAVLDKSGWMLIYHLKQIMYVEDGDREIAIPSISFRAHTAATESTWLSDTYVATIGNGVLHDMVTPDVRVIDTRDGDVGCQNTSSLSNVSSPIIIDNTETSSPGSHPDHILRCVTDMHIPCLCIWDLVDFNKNNSPKLKVVIANSTNVPHSIFHKKKHASSAVRFTCVLPIPAMRLDSRNSNGLEYDMVVFDSMGDMMLFSAATSEITVTCHVHSCAVVKCFYVGGNIVTVTQDGAVAMFRLNGIFSEPTRIFEGVAQPRANSADTTTSDGFVTSISEYLGIKFVESPSREACTNKATLLPEIIDAQIIQNRFLVLTTADGNATVTELPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCW4</accession>
    <name>A0A061DCW4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">REGULATOR OF TELOMERE ELONGATION HELICASE 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0308380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769120.1">
        <property type="nucleotide sequence ID" value="XM_012913666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCW4"/>
    <dbReference type="STRING" id="5866.A0A061DCW4"/>
    <dbReference type="GeneID" id="24565475"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308380"/>
    <dbReference type="OMA" id="YNWYLRE"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="182"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1042" mass="117209" checksum="C7BB7EEEF56DE3A9" modified="2014-09-03" version="1">MRGRDERRFIAASEYLRAQHDDTDGPGPTHTDGYEREALLDHSDTKGLSFISTRWRNDPAPDPVFRDGLQILRIFKEHGIVKHDDARILRSEDVRNFFIHMDKCYKTQKISMSELFARTLQSLRALPGIIKQAKLHNKAGNPNGGAPMDDPSDYRHNDDMPSPRVEVVVEWEKIKMQRIIGGLKVLFPFPTMAKAQIQILAKLINALKNAEHVILESPTGTGKTAAILSGVLSWMYQGHVQNTVAYDNPSDESQASTSSSSSSQAEVSTKVKARVVYLTRTHAQIKQVMAAIKKSGFRPKSCCIASRLQLCIYKPKKHNEDEENEGSDNDADDPKNRVNSQCRQFIANVDKARASAKQSVYTCSGRLITPKPTLSEQMCPYYLNLGCKNYAISTALRLMGSDNATWDIEDLISYGMEPSHPDASVGCRCNEQADARPTKKREGDITNYFTRKSHYEPPPSQDGVCPYYTAKAVAQVADFVVCPYPYIIDPHTVVRGNAIPNKVATILTTDTKYQSVKSEIIEIISEKTNISGSAGNGIFSNLNNTVLIFDEGHNLENSCIEEASWDVGLDYLKAVLKWLFFVRAKIKAMDDIDLSDNADKSSLKAGGQLGKALVRVITFLQELIEGLEKFLHSTSDDSSGRRKGNSYERVVHSWDRYDQLQNPLGGSAEFIEAFNLDITKVYIVYCSMMQIKSQARTLSLSGVRLMEDYIFQLEYMLAIMVMLCHMPECYNVQIVANGDNAYSLGIWLMNPAVMFNELALNARSIVIASGTLAPIPPMVASLGAEFEKRLKNNVISASQTLTKNQLALYTVTHVSNCRYNNDVIECNFKNLKDNAFLLQLGNSIAKLLEVLPGGTLIFFPNRSAVSACVQLWGETFYDAGPRRTKITILERIMQCKDMNFYQEPTLAADFAVMLKELHEQREFVLFAVYRSHSSEGLNLKLSSLILVGLPFPSIVAPKVGMTRRYHKSQSEPYNWYLRETYRAVNQSIGRCIRTKDDRGVVILLDRRYTAAKEYLPYWIHPYSRAPYTVEGVRDDIEANFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD59</accession>
    <name>A0A061DD59_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0211220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768161.1">
        <property type="nucleotide sequence ID" value="XM_012912707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD59"/>
    <dbReference type="GeneID" id="24564516"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211220"/>
    <dbReference type="OMA" id="GPESFDH"/>
    <dbReference type="OrthoDB" id="366279at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16141" checksum="BF22689C706EE3DD" modified="2014-09-03" version="1">MADESAFDACTDGDRAFEARGTLESLWRAMTNGEGPESFDHISFAGGVCFGTGFSIVLGRTLRGFCLVAAGGLFTTLILNHYRLISINREAIAATVTSLALSARERIDEALQGSGGPLKFLSGPLFGQHLPRERVISALAGTGVGFTLGLIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD78</accession>
    <name>A0A061DD78_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769355.1">
        <property type="nucleotide sequence ID" value="XM_012913901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565710"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310720"/>
    <dbReference type="OMA" id="NRIMEIH"/>
    <dbReference type="OrthoDB" id="360880at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600287" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1688" mass="193762" checksum="006CFD272028C0BC" modified="2014-09-03" version="1">MTGHITVCVILCSVCIAALFPAEALHKTHVKHRHVTDGALSSINKAAPRLQRSLGCLVNTTCNTSGTYQTSGTLRRNRSEVACGDIRPGVSHRAQSAGRRKMRSSNHEATFVGHMNVEPRVEQHMARKRAATDKSSTGAWGGRTNSRLQAKDHFENPFLEKPKPIDLPPDELERIRDMLDRVYPDDAKEDEDEAHPLSDVLLRYWGRKPNARDCMMQLVDKILEEKETTDDDIEICKRLGLEPPPTIKHELASAMLREMFNMRQKPKSFIQTLVEALGLRKLMQYIRGKKEGNVKSKWPFGIELKDPNMEITPLTENALRGYLGLPYYDHVADLAKRNPENARRILTIIHRIYKPPILFIDLHPDREHTDQDLYMDSENLKRAQGEAYKHFVNTYPDLKWPVDDQSFLDIYNVWYPEDKAVPADSLPDLMREEYGPGMNLMPPNFYYRFIGVPAISCATGAAFGGLLASAIGGVAGLVGGIAAQNLVHGIVGPKACSVALAGATLAGLSRDMTVKGDLFNVALKNLVDNAFEDPRAVINAAYSGLVPKDDVVKGLEKFTIHCTLTAFSRAMRLAREGKGIKTWNLLAKQLGRVAEICLPICGASVYRVIYFAACDLATSNDLPCAEGDEVLGRQISGDPEFSDDDYTDLYEEGCKELGIPMPDVAKFERTAMLFTTFVLQAFGGIQNFKRKSDEEIDKYKEFVRALKEFDVSDDAWDNLKDEPMATSTLDDIEKFARELDQIGGKFKRITLEREYGVDTHNEFLGESDEEKHLRMQIELQQARDAVTDLAHKVGYKLEMLKALSMALHVREEWLLPKYTQFLKQQCVEFIAAEIRNQTGNLEEMIQGFHIAKKHTEEIKNEAMFYLTQKLHENKALNHDEVLEMARVANISEQVTLDACSVAMYQDLKDELATWDLTAVTPDQIREIMQRYRCRDLVFVNAICDVIKKTASEAKKEMINARNKLNWNLVEKYMSSLLRGRNAVVNAAADTIDCKLWYRLERAFRHNLQYIDYKLGRHQILGTGEVAKIENADWEMLDPPPQKSEWKQLEEEWEADLKNVEPLKITGEDSLTPIPLQMELSRMVERGELDPRLECVPNEFHIGERPKELEYEPDYKFPEDPHALDRPIIDSRLAYACWVVYCYRKRAVNEEDIKTVLTIFPFLKKLVEKSDEHWRRLYARQRLRQKDSLGSNVDWCRELDCDEEMAQNVCAVAYEEDLLKRTGAYVEHIEDDIGDVEDHYFNPFDPSVYNRITYLYSSKVPSELELENIKKIQAFFKLTPQKIAEIHTKCFSHALDLHCGAVMKRSPQDWPKAVEEELMPLAKELLIQETPFDMILRKTEYDYLIVEANKLMMKRTPGRQFLDMCEFIIDEFKRLGVMYMADGKRRMRFSIRAQNSAIMEEIMGAFIISHVDVHGKVDQEKLDEQCAVYGLIKDTRREVLNRLGRKFYHRFLQKFSNEELCLESLNEVEHLHRAYELGPKEVEEIYKTHVGIRIREWYDPESGLEAMKKLVTILRGQDFNKFIPFERSRRIHWFINIINDCINLGEDKAETRVFTYPLEDFFALHFEGGEENFDSLQGIVNLSRRVLTLTPEELREARIIVGEEIGAAALNNVRQRLLTRDGVYAADTEMSKFIRAIAFAPPDELQTVKKELPHIKNREELRKVIMLIPCSDEALAKSLRMLDELMPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE1</accession>
    <name>A0A061DDE1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0301100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768391.1">
        <property type="nucleotide sequence ID" value="XM_012912937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDE1"/>
    <dbReference type="STRING" id="5866.A0A061DDE1"/>
    <dbReference type="GeneID" id="24564746"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301100"/>
    <dbReference type="OMA" id="CMKVRYP"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="323" mass="37063" checksum="72CA466ACBDBBB31" modified="2014-09-03" version="1">MERDVDYYLSEVDVGELEVTIDRIFNSEAISAQTVVKLCNKAKEILAAESNIIPVTAPVTVVGDIHGQLYDLKELFRIAGTSPNTNFLFLGDYVDRGYYSVESVSLILALKVRYKERVFIIRGNHECRQITQVYGFYDECLRKYGNADVWIALTNIFDYLPLGALIDGRIFCPHAGLSPSFDSLDQVRDLNRIQEVPHEGAMCDLLWSDPEERTGWGLSPRGAGFTFGYDISKAFNRTNGLELIARAHQLIMEGYQWSQDRNVVTIFSAPNYCYRCQNQAAIMEIDERMRFTFLQFDPSPRREPPEKKERNNDYLLEDLTYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDG2</accession>
    <name>A0A061DDG2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0312720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769555.1">
        <property type="nucleotide sequence ID" value="XM_012914101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDG2"/>
    <dbReference type="STRING" id="5866.A0A061DDG2"/>
    <dbReference type="GeneID" id="24565910"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312720"/>
    <dbReference type="OMA" id="QAGYGHD"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16074">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="826"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="973" mass="110031" checksum="CBB3ED23B8E3E24A" modified="2014-09-03" version="1">MCAWYEQDDRNRGRGSDGRERPHDEYDRDYYRHDNPRVPRDRRYDDRSSGYEYGHRGYDYRDRDHERDGYRRSYEESRYSGGTRDRGYGDSDRGYDSYSHHYDDRPRDGDRTESDYDRSYPGYRNRGRDYDSGYSREDNRHGEYATEPVYDNSGTHSSASRSSRRYGSEEDWSVPRRDMASNRQHQWDDNREGSRDDGRDDDGVMSRDHERRLDKHDSREADDSQTRNSQYSGSIHEQQHSGDGTREYVSRGGGTTNGFEYGHGSYVDSRERIIHQSTGNHGSGSDEYRPHASNIGGRNNRQSNHESTDKEHWYQQPRYQGFGSRKNREDSRESGGAHGYDRPRRGYNDTNADENSATILVRKLPPTISGEDVESAVSDLCIQNGTSAPNAVTVKSCHSGYGGMSDMYKGADMQHQVNPDGYGFGASTEHFAVVTFPSPANAARFMECVKSRKLELNGAEYYVEYDTLDVNAEKPVSEVPRAYGSFQELEEMIKRRALSCDWICPDCRFVNFARRSACLTCDKPKPSDEQLQKMNLLVENAVSVQSQPILSNVTDVSPWVVLKGIPMAADPTKLVLLVCGSVPEGAAHLQRCVYVIDPQPQSRRGFMFCQFSSATPVNAFNEAMGDKQSALLQYQDVYLRLDVVRSREKQVADELLKGVRMNTLRVHYEYHPETFAAAALSEEPASRQIGNKECRSCKVKTTNVGALEQLCQSVNAPSGSKQYLDAWTCRSIWVTSGKPDTAKMTYDPNSDYFYDHRLGVYYDAASGYYFTVGGDYYRWDEPTSSLIVTAHPASQGDHSQSSNEAQRHQTQGDVAGLLQAALKAAQMTNQTTQKTAQKSPDSVPQNTVEKHSPPGVQEVDQTHQGSEDRHGLTNSASRPVYGLQPPPEVAMTFDLGDHSDDECDMEVDSIANRPATEKIAEEKGGNKKWTPVVKSLSVCLVCLRMFRDQAHLDLHERRSQYHQALLECGDSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK1</accession>
    <name>A0A061DDK1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768501.1">
        <property type="nucleotide sequence ID" value="XM_012913047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDK1"/>
    <dbReference type="GeneID" id="24564856"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302190"/>
    <dbReference type="OrthoDB" id="10477355at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595731" evidence="1">
        <location>
            <begin position="33"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="90" mass="9505" checksum="04EEC68E6A7DDA5F" modified="2014-09-03" version="1">MAVCYRTLHATLLATLTFHLFCASVLIPSSVATSVPLSTTSPAVRFMGVGGIGVDEPYPDVRVFAYTPRGSFNPSSAAVTEAGKFSFVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK4</accession>
    <name>A0A061DDK4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0302290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768511.1">
        <property type="nucleotide sequence ID" value="XM_012913057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDK4"/>
    <dbReference type="GeneID" id="24564866"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302290"/>
    <dbReference type="OMA" id="YKRICIR"/>
    <dbReference type="OrthoDB" id="366272at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="413" mass="44193" checksum="C6BBE9C9BF5AE671" modified="2014-09-03" version="1">MSTGGVGPSSDPYNNHVIYVNPRQYKRICIRREQRDKMLLKRGRPRPSYLPVATRPESNSSKRKRDGSESPHKIPPNVDPFSQAAYFYPPTRYAKSRESDRVSSKIRRFNDRNAAEFSNVAALIAGNGYNSNYTGSVIPGTAPHSHGSEYSPHKERVSYVEHNAAESTVPGRLVAHVGSYCGAHNAGAMDARATNDGRQSEAYGRIDSYPEIHARSVNRGYRFQQSSGTSDSYSSASSASSYSASYDGRPMSSGSTVVMPVHSYPAAAGSQGVISADSYAGSKLGQVTYSRGAYSAETYSGESCCSDGHWREDYGHGSDGVDYYVTNTNSCGNRASESCHNGRYSDGDNVEHGVGESADVATAGEMSCAYAQHVVAGAGAYPASGMSRGGAQPVLRGPMCSEYVYVAGADAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK6</accession>
    <name>A0A061DDK6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0302340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768516.1">
        <property type="nucleotide sequence ID" value="XM_012913062.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDK6"/>
    <dbReference type="GeneID" id="24564871"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302340"/>
    <dbReference type="OMA" id="MNPKEFN"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="499"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="690"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1366"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2156" mass="243203" checksum="77FA36BA54449D60" modified="2014-09-03" version="1">MAEQYERFKRFEYRTNSNLVLQRDGHGPKANEATGEPESLATRLKYKMGDKVTYSVPKRTTDNKRLHTVDTSRGPAKHRRTRLDLKKGESVLNVDITDSGYYVPSSLATRNKYEEILNLLQETLVDQPQEVLKGAFDEVMTHLRAAGLKAEERRKLCEDVLGPLSDDLFYRLYHTAKELVDFGTGDAPRDSTGVTDDPAGIAVVFDEDDEDDESDVHSVEAEEDEDDEHEESHIQTIRKDGVEFADTDKYHLPISKIDPHWLQRELNLIFGDPNLAVATEKEILAVLGIPDIQECENKLVLILKYENFEFAKLVLRNRWKIMYCTRLGQAQTDEEKEAIFDEMKQVQEGIEVLQELEEVHLRRTKDQELTLNVTREAANLARQNAKREGNELQDGDEEELIPEPTAIPEDIAQAGHPTVVDLEALAFKDGAQHMTNTRVVLPPESERVEHKSYDEVIIYPLERPKDLQRKSIKTLPEWTHAAFPGVDSLNPVQSVIAEIAFEHFEENMLVCAPTGAGKTNVAVLAMLSVMSQHRDEKGQLNLNDFKIVYVSPMKSLVMEQAQSFTQRFAPYGLNVRELTGDMSLTRNQLMETQLLVVTPEKWDVVTRRSGMENSVQLIIIDEIHLLHDKRGPVLESIVARAMHNDRKNKMKTRLVGLSATMPNYTDIADFLKVNPDRGLFYFGNHYRPVGLEQRYIGIKEKKAVKRYNCMNEIVYERVMEDAGKNQILVFVHSRKETARTAKLIRDMAFKTDALNIFLHSDSASREILATEAEAIKTAELRELLPYGFGIHHAGLPRSDRKLVEDLFSDGHIQLLISTATLSWGVNLPAHTVIIKGTQVYSPEEGCWTELCPLSVQQMMGRAGRPQFDKEGKGIIITAHEKLQFYLSLNNQQLPIESQLVSSLPELLNAEVVLGNVTTRKDAVIWLRDTYFAVRMRKEPRLYGVIEAEDEGDDEEESGNSTTIDEQLFDIRLESLAHSALIELDKYALIRYERRSGAIKSTPLGRIASLYYLKPPSVKTYVDNMKADLSDSDILKVFSASAEFKYIPVRDEEKVELAGLMEKVPIPVRGQGQEGTSKVAVLLQSYISRFDLDGYALVSEMTFITQNAGRIIRALYEIALNNAWSQLAQRLFDLGKMVERRMWSVMLPLRQFKSLPEELVLKLERNDFGWDRYYDLSSVELGELCRQPKLGKTIHKLIHLVPRLDLQVFVQPLTREMLRVEVNITPDFQWDPKLHGSNEKFWLFVEDGSGEKILHSQTFVLLPFTPGHVEDYSVFFTVELSHPLCSHYFLRLTSEKWIGSESKISISFSRLILPEKAQPFTELFDQQPRPISAMINLPGEVVALNKAFFRKAFGDSHFNAIQTRVFDAMYSQSDSLLLCAPSRSGKFTCAEIAITRCLCTCENATVVVVSPFKTVANQRLERLRYKFGDICQVNSLVGDVKTDLMVIAQSTIVVCTPKQWDFVSRRWKSKQCLQSVDLFVVENLELLDDPSVGPELEVAVSRMRFIAAQLEYPTRIIGLGGPISNALDVGGWIGATAASIFNFRPNSHRAVLPKFTIQSFDQWDSETRRFSMFNNACNFVLSHFRESDDDSCSALMFTVDRRFCRLLAMEVLLSIEYHVGVTGASPLLNEASNEILAKLMARERALSKLMEGGVGYCHDGFSEAEIKVMEDLFRRGQIKVLVATASAIWSLTACAPLVVVVDISVSATNRPISQGIYPQSDLLRMLSCAYVPDELSTIKPHAVILYETSKRRYLYKLLEEAFPVESCLEARIEELVNAEIVQGAIENAQDAIDWLTWTLYYRRLPKNPNFYSLQGATAQHLSEHLSELVESAISALEKSQCASVADDTVSPLNLGYIAAFYYLRCRTIETFARSVTPDSNRDSILELLATAEEFADIVVRTGERIGSQKLAEGNTPQKVKSLLIAHMDRTPLTNDLQSDQRTVLEKMPSLLCALVDVLSSNGWLAPALLVMQLGQRIVQALNPADSPLKQLPHASAAWIGDANKAGVHDLFDLMGMEDDERTQLLSGFTQQQAAAIAMVCNAVPVLDVQCVLSDEKVAPQQPVNVNLNIEREGDMEPVHAPFFPLERFEQWWVVVGEAKTKGLLGIKRVNLPKSNNTVTVEFEAPAVSGKHEIVVYVVSDSYVGTEQQHTLVLEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDL0</accession>
    <name>A0A061DDL0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769700.1">
        <property type="nucleotide sequence ID" value="XM_012914246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDL0"/>
    <dbReference type="GeneID" id="24566055"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400100"/>
    <dbReference type="OMA" id="DEARFMI"/>
    <dbReference type="OrthoDB" id="365798at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32942" checksum="8693ED45EC0CF893" modified="2014-09-03" version="1">MRMAEPRRLQSFHVGHKASATRSAVYVRSPPGSPEARGTGSSASIHATSVDDADRCVLRNILRCFHFLDFEDRGHISPAEAMAFIAPLKRASPDLFELLCEVLAVTKHALVDGRIGKEPFIRQLESSLRALARDDNSPLAQLRQPCNAISRYFGSLKTAAGECDDNAIGSPGRGQEQIRGGDLYDSQAGRGDERPAWCTDLAGTREEQRTQSDGECTFKPVTNRRRFTAGRSEASVALKDEIRDMHRFQYGRLSDGTTAQRLSGNEPRGGMSEYIVFHFSERKEWSQDLRSLRNPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDM6</accession>
    <name>A0A061DDM6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768576.1">
        <property type="nucleotide sequence ID" value="XM_012913122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDM6"/>
    <dbReference type="STRING" id="5866.A0A061DDM6"/>
    <dbReference type="GeneID" id="24564931"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302940"/>
    <dbReference type="OMA" id="KFIRQYT"/>
    <dbReference type="OrthoDB" id="361033at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="408" mass="45200" checksum="D666AF17DED9DF7C" modified="2014-09-03" version="1">MSKRKEGGEGGTKSESVDTLSAYLQKKSPLLGSLEFDTSIPEPPVDANLLTYELNEDAIAYELSALELYAGFTSFRDFENGVTCESFEPASYSNYAIENQELLDELGAYAQNLDAAGMERLTRLRAEALQTREMQTLYPLINKLRDAMPNDVRHVLFAAEGVEPKGPPADRVPVTQPDSSADDQEDAVREKWSSMSVAERIEHHISQINDTFVSASSLKHPTNPRAKIAKHYKVMPNVGLWKNRYVQVGVDGVTSASATEDAGKLAVGGILHVAKDSATQRLYEYYKSATEDEEQDVKHNPGSQELFKFVRMYSCQQSTKVEGNDNYFLISLPPRLHNKVKTNTGASGMASPRPDEMDIEGDEEDDLADSVVHILPVKGQKMVLTKAGKAKVPDIMLTYTEDIVLRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDN1</accession>
    <name>A0A061DDN1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AcetylCoA transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0400510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769745.1">
        <property type="nucleotide sequence ID" value="XM_012914291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDN1"/>
    <dbReference type="STRING" id="5866.A0A061DDN1"/>
    <dbReference type="GeneID" id="24566100"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400510"/>
    <dbReference type="OMA" id="RRKSWIM"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="487" mass="54855" checksum="A7C78A7C64BD912D" modified="2014-09-03" version="1">MELNLPAGFPKPVALQEVPKGHSNYTWEDIKCMLVLLALYTVQGIPLGLRTALPLIIYDRVSYSQMAYLSCTALPFCLKLMWAPVVDVLYWRRLGKRKTWIIPIQIICAVLLLYGGFNNKMDRWVGQYGEPVDIFALTVYFTVLYMLMATQDIVVDAWALTILRPEMRMHTSTCNTAGQAIGINIAYMGFTTLNSREMRVYVDRVWGWIGWFFGVRSTDLIYEDEMELQPFVSLSGVTWIFGLITIIITIMMLKPAKMLAIALLTCNFFFVVENPAELQILEKGIHRDVFAAVTLLFVPIQIIFPPFVSHGKLTTISFKVTMGMHHSSASDILCKGLKIRLVTVVLYTGLVTVTGSFYAKESHSAFTSALFYTCFFSISVFRKVCELVVVVSFNGLFARVADPSVGGTYMTLLNTLSNVGEILPKMIGLWMIDVFSKAYGDGTDGLYLETLLCALGGVAFLPKFRSILTRIESFELSEWYLNKFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDQ1</accession>
    <name>A0A061DDQ1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0303640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768646.1">
        <property type="nucleotide sequence ID" value="XM_012913192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDQ1"/>
    <dbReference type="GeneID" id="24565001"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303640"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="566" mass="62693" checksum="63030BFA1046BE1C" modified="2014-09-03" version="1">MSEPQITSPADPAVAHVEDGKKVEKQTEDYGTFGQVLYHVVSFTEGYEQQVLYLCMRLFESTMGFTKRQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSSTSRYSSILFLRFLHGAAFGCIYPVQQKIISDKDDDDERNSSSSTFTRLHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYVWISVGIAIIFAMQTKHELISPYGSIMGFVEQISGAFKAVFTNWSAFLCIFTMLIAEAPMCSLPYMITYLEYLGVSDMKVGIAILVTTIGGAAGSAAGGIVIEKITSMHKDYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAILGATLVTVGGVDRPIMRKVIEDKYQASASAIIQCISGISVSVSFVEIFAYVSEKLHGYAPSKQAIDDMDAALKDNNTEALRKSTMYMIVIGSLLNIACYGALFGTYKVDKVEVKQKNKIEWVERKKREEARQYSTGTLTEQEITEIPPDLEIPKERQFDVETPLSESARRDTDGTEKNGMYGGPGRSDDYEIVTPQMKAQMLRDGPSFRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDT2</accession>
    <name>A0A061DDT2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768736.1">
        <property type="nucleotide sequence ID" value="XM_012913282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDT2"/>
    <dbReference type="STRING" id="5866.A0A061DDT2"/>
    <dbReference type="GeneID" id="24565091"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304530"/>
    <dbReference type="OMA" id="FCSKWFI"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="68"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="332" mass="38351" checksum="A39B146904DD5343" modified="2014-09-03" version="1">MINSKLWEEERKSSLFNRSGVHSEDDLLSLRRKVEALVGRNECAGEDDILSSIMNYVCKLMSACNWWSSSPSSDEPLWPGEPRFEVSEENERIFRLDAERTFISEENRAVLCRNLTLVFRHVGDYHQGEGFVIAFLSLFLPAAEVVRLVVHLHENQLRGYFSCTPEAYVRDSRVLMRLLKGRNEELCKHLEGLLVPETFCSKWFIGMNVHVLPFEYVVKYIDKVLSEGERYIFSFGLAFLLFHAETILGCNDVSKVLQLLRLDDAILPPENEREAIYSGIMKLADETAVDIEQLSSLRAEVEKELQEQKEARERRMKELEGSDDEIVFSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE04</accession>
    <name>A0A061DE04_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770025.1">
        <property type="nucleotide sequence ID" value="XM_012914571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE04"/>
    <dbReference type="STRING" id="5866.A0A061DE04"/>
    <dbReference type="GeneID" id="24566380"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403270"/>
    <dbReference type="OMA" id="IEEWAED"/>
    <dbReference type="OrthoDB" id="365460at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="242" mass="27337" checksum="B32532043AAF97A7" modified="2014-09-03" version="1">MDSSKAVLIDLLRFLPLVEERLLGKDFDVSDTLQLTHLRQSVEMLESMAAKCESAISIEEASEIRKRIAVVRETVDVLSLRSSPAHSPSQYRDVMLLPGRGTAPEACDADYASCLNMTNEEFDALIEEWAEDRERPPTTIKVKKKGRMSSDVAEEQIRIDLVKLADTMKSKALWYRDLLVKDNEALSKYTVEQEKQLDTVTHAANEAAKLAKTARLSLRQSLFMIASLFFAVVFMMMVFIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE22</accession>
    <name>A0A061DE22_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770080.1">
        <property type="nucleotide sequence ID" value="XM_012914626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE22"/>
    <dbReference type="GeneID" id="24566435"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403820"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="421" mass="45649" checksum="8A0781061BF634D5" modified="2014-09-03" version="1">MVFNSLTEAPHNLKEGIDWLIAVKGTDAGKNIAALGDAVHKLLADKPVGYTDVPALEKVKRISKEFLEQPELVEKWPANNVLVKFNKPIDRKPQFFQKLFRSVDKCDYTNVVKETPLSASTITQKLGKAVNGFEKFLGKITSAEQYESAYSSEATWEKSCSEKPEDCAAVFVGIAPMLWAGIRTLDDASYPGDFSWLGLGNKKNVSAKLLSALGFKDAGCLSNTTAPNVSSAVAIVKNNGLQTFHDLSGFWAFYDCTKVPSVDAEPSVDGEGEQSMIPEAEPSFEGEGEQSMIPEAEPSFEGEGEQSMIPEAEPTVDGEGEQSMIPEAEPTVDGEGEQSLIPEAEPTVDGEGEQSLIPEAEPSAEPVKPEVDEVEQPVKVAKAAKVARSVKAAKKAAKKVSKKARQRKQKKQKKQQESAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE35</accession>
    <name>A0A061DE35_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">-Protein tssc1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0404320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770130.1">
        <property type="nucleotide sequence ID" value="XM_012914676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE35"/>
    <dbReference type="STRING" id="5866.A0A061DE35"/>
    <dbReference type="GeneID" id="24566485"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404320"/>
    <dbReference type="OMA" id="SSNDAWH"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="5">
        <location>
            <begin position="199"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="365" mass="39584" checksum="C5DBFF676EFCD7BD" modified="2014-09-03" version="1">MQILDSDANPGGLSGSGVVVHALRGRFNTVASLQSSEPSLHRFAAASSDFSASNRIVVVCYDENKGAVSQVARSPPLQPVKQLLDISNSADSLRFVLSVRDIEANESVVRVVDFDTGSPSSIVVSASSGPLESIIRAIDFDPCTIQSPDLRVAVVHPGLAVLLQQRGSTLESICRFQPPKVDYTTRLIDPLDTYKDRFITGKFDLHHRDLFACASGEGFHILDWRQAGESPVAVRNGQCHFADVLDIAFNPNVPNQLVTAGEDGKVAFWDLRATYEPLNVLSGDHKSCIQYVRFNSFHDQLILTGGPSATVLHLCGSGTHSVHQCSAPSRLGCWSSNDAWHFASLSGNNLVFETLPNAVKYKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA8</accession>
    <name>A0A061DEA8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome b5-like Heme/Steroid binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0405980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770300.1">
        <property type="nucleotide sequence ID" value="XM_012914846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA8"/>
    <dbReference type="STRING" id="5866.A0A061DEA8"/>
    <dbReference type="GeneID" id="24566655"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405980"/>
    <dbReference type="OMA" id="APIEDYY"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR98114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="109" mass="12305" checksum="E8D56F6BED7420C6" modified="2014-09-03" version="1">MMASNKDAIVQKAESPLDISEVARHKSEHDCWSIYKGNVYDITRYLDIHPGGRQHLLEYAGKDLTEEFLRVHPWVNGEFLLKSLLIGELKSENEKTENSSSIDSSGTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE8</accession>
    <name>A0A061DEE8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769341.1">
        <property type="nucleotide sequence ID" value="XM_012913887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEE8"/>
    <dbReference type="STRING" id="5866.A0A061DEE8"/>
    <dbReference type="GeneID" id="24565696"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310580"/>
    <dbReference type="OrthoDB" id="365975at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037485">
        <property type="entry name" value="PEX22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22978">
        <property type="entry name" value="HAD_Pex22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="27913" checksum="C6F727DABB755959" modified="2014-09-03" version="1">MKTSPAADAAFDQGIVFATILFGITSLLLAFCALYFRPSQLWRTRRAPPVETEEKRCDSITQIMQPPYRTVLKPSLSIFINDVGSHVEAHYIMQLVFKKGTYEIIQEHLAPLIPLGTKFQLYLFVQVRRFNFTMPTICDRCLIKRLSQLYWMPWKWPFFTSSQRVLFSTTSAGRASMTRQLQPLLHMESDATVVQTILGKVANVMHFAFEGDENGDDAANRPEGGDIVKIKSTAEIMTLLQPITTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEH0</accession>
    <name>A0A061DEH0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF hand domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0311680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the centrin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769451.1">
        <property type="nucleotide sequence ID" value="XM_012913997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEH0"/>
    <dbReference type="STRING" id="5866.A0A061DEH0"/>
    <dbReference type="GeneID" id="24565806"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311680"/>
    <dbReference type="OMA" id="HPGLTQQ"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="171" mass="19184" checksum="BE5F642949553E5E" modified="2014-09-03" version="1">MKWQTKPSGRSSASGITGRRRRELTEEQTAEIKDAFAIFDTNGTGRIEIRELKAVLNALGFDPTTDEMYSIMTVVDKDGSGTVSYDDYFKIAKTKILDRDPAEEIAKAFKLFADVNTGTISLKDLRRVADELGEVVSDEELAEMIKEADRDNDGVVNEAEFMKIMRKSNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEH7</accession>
    <name>A0A061DEH7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769486.1">
        <property type="nucleotide sequence ID" value="XM_012914032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEH7"/>
    <dbReference type="STRING" id="5866.A0A061DEH7"/>
    <dbReference type="GeneID" id="24565841"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312030"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49041" checksum="A1759E55B0BAF7F7" modified="2014-09-03" version="1">MYLPHEINRIKDQRRLRQRGIADPSDLGFGDAGLDYDEKSAVGAAGDAEGDDRVADEGGITIEPFHMRREMQEGAFDTEGTYVESNRKMTSTNRSLNRDEGDDPWVASLEEQNSLSFKVRYQCLYASFTCLQAENGAFYAKQPVRASASTPDLMEQLQDVPTIDVIKRLITLLEPGETPVDALKVKRQQSGKRCLPGFRKQERDAADASAASQGAESKHKKETGPKDLSKYDVSDLAHVLTITWQNVYYMTKEDIRNALAAAKNRPKRGGKSAPPTRYQFRWVRGDGVVYGPCSEVEVLSWIAHDYVSDDNPIELREVGPDGTPLDEEWVGHRDTPLYNFLNPGAELPGGVKRGRADVGGNAASDTADKVASGDNESNIATSGGGAGESNGVGGDPSTGVNEEESDDDDDDGTFAKRRRKDELIGIKPSTKKADEDSGGSDDDDEPDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEP8</accession>
    <name>A0A061DEP8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Single stranded G-strand telomeric DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0401470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769841.1">
        <property type="nucleotide sequence ID" value="XM_012914387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEP8"/>
    <dbReference type="STRING" id="5866.A0A061DEP8"/>
    <dbReference type="GeneID" id="24566196"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401470"/>
    <dbReference type="OMA" id="KGWGIVE"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="115"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="21926" checksum="C8D5DB3B87C379AE" modified="2014-09-03" version="1">MSQNSNCRVYVGNLSWKVKWQDLKDHMKQVGEVVRADIIEDYDGKSKGCGLVEFADEETALRAMRELNDTMIYDRPIFIREDREGPQSFRGGRRGPNRDWKQSGGGNGTGEPAGVCVLVTNIQWRTSWQDLKDLFKTCAPVNRVDILTREDGKSKGVAKVYFQNEEDANRAISTFNDYLLDGRKISVKFEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES6</accession>
    <name>A0A061DES6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769981.1">
        <property type="nucleotide sequence ID" value="XM_012914527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES6"/>
    <dbReference type="STRING" id="5866.A0A061DES6"/>
    <dbReference type="GeneID" id="24566336"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402830"/>
    <dbReference type="OMA" id="SEAKCEL"/>
    <dbReference type="OrthoDB" id="364973at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="745" mass="83599" checksum="620297D11FAFF77B" modified="2014-09-03" version="1">MEALLSLYRRTVAADIEDTLQPANAHTLQRMLYESSDVFGELSKYDNFHQAFGVPPNPCESVCFIRFWRGVEDVVTGPEPVITGSRRLDLQKALFADDALLRSVRHFRDELLKQTSRMSLTAFLSVIDCCNKSSDLPEFWLRVRENSHRTFSKGDIEVTHVSDMIFGHLCQRFSYRPQVTSNLCTISTCTAFESDEDSDPVDSSRSFMSSVASCRSAVSSEERYRQLLENLDVCLPEIYNRFCERIDELTTQREQLEAECESREKQLDELRSELAAGRIELQSRCDQLVESNSMLQRQTESQEIELDSYRIQVMNLKRRLDSCDSARLEDEIQTVRSQCASLEKMNVDLRRSLEEAEARRSLASSNHTDRTDVCVGDDIEYVEPTTSSVLPEDAWHASDERATMLSEIQRFRAENAELSKAFEDMVKREKDLSRDLAAALRDNEVAAERLKCSVPADSHAAGQQALQSKILSLETEVSSLRELVESLRSEGEVAESERSELLCAKSDLEREIAASRKATEVAETALKLLRQKCSQMEAEVAGTRDLERQLYEYRTCNSELQAKIDELTTENLSLAARIEDLNAPPTRLSGITGTIEDQVDDTCFSVTPRAVTTAGDEQENGEMGGQYIGMIKLNPALAETRRLNTLNAMKYGQLSAGDSDMPLSSVLGKEDYGPLVYRRTFGFERSMTVLSDDTGIALLRDPSDPGVNDSDITPLTDTKTFDVLQSAASYLSETFNLGLKTGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEX4</accession>
    <name>A0A061DEX4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0405190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770221.1">
        <property type="nucleotide sequence ID" value="XM_012914767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEX4"/>
    <dbReference type="STRING" id="5866.A0A061DEX4"/>
    <dbReference type="GeneID" id="24566576"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405190"/>
    <dbReference type="OMA" id="CDENIKV"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR98035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="376" mass="42687" checksum="9A146644AF97B0E9" modified="2014-09-03" version="1">MVALRGVPLASSALLHAPVLNSKHLVIEIRHGEMCMNEFTCQQLLSRVKENCRVSDIQPNGLITYRDCKQLLSDTDYIANIDTRFECILVRLYPVSAIVLHDSVLVIANGNMNLDDFLRSLCSITREYHNNEHSSRSPPTHGGRGSDDVDASADSALPFEVKILECCYMASLNNLEGDMAAIEEKFRVVEQMVHEKRRYQEINMILHHLKQPVVNMSEILKGFTDMMDEYLNDEDSMKLLEFESHMLFYGPETLRTGFEDRTVNRDLENLMEYFDQEVDQMARRSRTLGTSLNELEKHITVALAIKRNEMMRIELICSVLSTAFGAGACLTGLFGMNVVNSFEESHAAFIVISVIALLIMCIAVLGMKILIYRHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEY3</accession>
    <name>A0A061DEY3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770266.1">
        <property type="nucleotide sequence ID" value="XM_012914812.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DEY3"/>
    <dbReference type="GeneID" id="24566621"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405650"/>
    <dbReference type="OMA" id="FKHWRNT"/>
    <dbReference type="OrthoDB" id="365331at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1374" mass="158142" checksum="0A694E0DD62C5A5B" modified="2014-09-03" version="1">MVKGVASDSGEASSASSLSSEELIRCVAKYVETCDGSLESGASFDDRCKFRVSLDQVCCIHSRSLSLDQAIPTPRAALKHVRKHNTLFRWARSYHGNVRESVANEIANVCCTKNRVKMTLKTLTCASATERYSNASAAIFYQTSLASRMFRSFKLLTQRKKECNRLIPRMAELIETSLVAQCINPWRHYTKQKKYADACSKEIACLRDENIKGAAIVSWQAAHRYRLGSVQMEASCRSFVLRLAWERIKSLHRDSVQKEALVQHAVLRDAVSTAFDCWHSAAKEKQAAQYRSFVLKYRSFSALRQNTERSNEPPIPSPTSDPSENDIPVHSTIKNTIKSALQHKRDIITAAGLLTKAMHKELKRASLRALCENSNRVAKETIKTQLVAYIRKKHIAKRTLVSWKMYSEMRKKKSSMKHLADLNYRGYLVSHFFDYLRSIYLENIEEFHKSLSLFKTQQRKHHHRAWFRAFLVAVERSRSLKTARSLIEASQKAQTLHWAWRSLEERCDNNMMRKLQCIARIGSIKLDESLGDPHMWLRTLREVKLRKSHDVKGLCHSLREQHLGPNIVSVLTQPLRSECVVFLHYLSGLKTRAFEMIERLDMSADDAVVRVCSTLTPTELGELHSTYAYQLYVMRLEGFPQLNSLPESCNTEHSKQSTKALSPHFGSNLKLCGVLEPDYGVVNGLSESVCGKVPIDLQRDATSSPHSNYGGSMRDIPEWSVDLLQHLTANKLLGICDMRSQRCTTFDVLNSRLPVWRLLLTVFAQARCASTFQAWKRISAERSSRRAKLSEVRNSVEGIFKMSTRCECFTRWLEVTRKCHEQRVAELNERCTTFTSIFSCLVYKSVSIVFIRLHLARLMAIYTGAERMRHMKFLSKAVVFSCRDGDACAEISVFRSYTVLGRLFCYWKMLTQWRAEVTSQTDAFYRDLFMRKGWRTIQSVFIERCNSRTELESSLKEEITVRRLGNAFDLWCKTTRCKKALSSFSPSEDVVLQRCFNGWKAHVRNNIRLDNISEIIRKRVETSLLGIALEGMLEHYFRRCSLASMRSRVIAASSKRALCAAFTTWKDATQRSARLSALHYEIKRRRDNIEQEYVFSIMYRFSLVKRNDSNRLKRQYFEYVVISAATRKMSRTIEQHWTTTQNAICRRFFELQRIMKKSEQALSKISADKSRLYVALMALSSLKETRIVAGLKALQQNVHYNIAMKTIQQMRDRAVSQRIFTCWRKCVSFNLRSIASSKVGHRQLVEPKILGKYSEGGAIELNASGGDTLTADAMGRYCLVLACFKHWRNTTLMLPGRNAVAIVEEFTAHNRMVDGIYLLKLHALTSLWYRTCKARLEVLVGSMEDRMKWSMFHQWRMAAKKRMTVNSQEFPFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZJ1</accession>
    <name>A0A061CZJ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HVA22-like protein putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0101320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765989.1">
        <property type="nucleotide sequence ID" value="XM_012910535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZJ1"/>
    <dbReference type="STRING" id="5866.A0A061CZJ1"/>
    <dbReference type="GeneID" id="24562344"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101320"/>
    <dbReference type="OMA" id="IFNYFAN"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="243" mass="27919" checksum="AF3E6084F5DAD4F5" modified="2014-09-03" version="1">MENEVENNLSSPREAPKFWDCFQDGAVDWIKLTRYFDYQAEAFPLMTSISRVVKLSPGIILIISIVALLIIFACGKGTTIICDAAGLLYPGYKTYKVIKLFDGCPAIRRAATQELNGAIGIDGSTPQEQLMFWAKYWVVYSLAFVFKYMLYAVFFWVPFQDLFKLCFVVMMFHPKLRGAELVFNFFVFPFLIQYEKRIDGALDFVDKKMDELMKNYSHYAMNPKLKERMAQGAATWKAATQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZM3</accession>
    <name>A0A061CZM3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766034.1">
        <property type="nucleotide sequence ID" value="XM_012910580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZM3"/>
    <dbReference type="GeneID" id="24562389"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101770"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="85" mass="9476" checksum="53B326EF440EAC94" modified="2014-09-03" version="1">MEQVIIDTANYAEDISTFVKHIAENLDRLIHFGPPPQKHHSERDKNDNAREDVEQSSNDTFSAGSEDGTEDLPPEDHNSESEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0A6</accession>
    <name>A0A061D0A6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0105700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766447.1">
        <property type="nucleotide sequence ID" value="XM_012910993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0A6"/>
    <dbReference type="STRING" id="5866.A0A061D0A6"/>
    <dbReference type="GeneID" id="24562802"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105700"/>
    <dbReference type="OMA" id="DRIMARS"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="326" mass="37060" checksum="016CD039904B4A57" modified="2014-09-03" version="1">MTLPYNLPLTRDAVNRHFKEVRQLGKGAYGTTSLLMDTFDNSIVRKRIDVTSLSELIANINHPFIVKYLGSYLEGNVLYILTHYCKGGDLHRYIAQKRKHDEPIREERILKWIAQLLSALKYLHKRHILHRDLKSLNVLIDSDKSLKLCDFGVSKTLSATADHTKTVIGTPYYFSPELINGQEYSWPSDIWALGCLTYELATFKTPFDGVGGMQQLVRHIKSTPIPDLPSAYSLELNALFRSMMFQDMKFRLSASELLATDIMQRALRLMLREAELKSPTQIPDCTSSSLLKSKLLSTIPDDSEAVGGINNRHQMTIQIGDQELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0I2</accession>
    <name>A0A061D0I2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">cAMP-dependent protein kinase regulatory subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0104870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766364.1">
        <property type="nucleotide sequence ID" value="XM_012910910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0I2"/>
    <dbReference type="STRING" id="5866.A0A061D0I2"/>
    <dbReference type="GeneID" id="24562719"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104870"/>
    <dbReference type="OMA" id="WSPPHHP"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="63"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="186"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="316" mass="34936" checksum="01839A66E67EECE4" modified="2014-09-03" version="1">MSDNEIDTAMAEAARFARARNRLSISAEVFGQFNNPDSFEAPIHGKTGEQAERIKESLQKCFLFSSVDNRGINILVGAFEAHDVTAGTKIITQGDSGDKLYLVESGTAEFLKKSIDGNEQSLGKISEGGCFGELALMYNAPRACSVVAETDMKLWSLDRSTFNHIVRAAVIKKREKYDKLLRSVALLNKLDPYDRCRLADALKERTFVDEDIIVEGTTGTSLFMIMEGKAHAYCQGKLVKSYAEGGYFGEIALIAQTPRASTVKAEGKCVVVELERESCVNLLGPMEECLRNNLEEYHRVLESLNIENKNLASVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0T9</accession>
    <name>A0A061D0T9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial inner membrane translocase subunit TIM44, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0105620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766439.1">
        <property type="nucleotide sequence ID" value="XM_012910985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0T9"/>
    <dbReference type="STRING" id="5866.A0A061D0T9"/>
    <dbReference type="GeneID" id="24562794"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105620"/>
    <dbReference type="OMA" id="HAYTATH"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="7">
        <location>
            <begin position="232"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="391" mass="44548" checksum="F4332F2E5C44A845" modified="2014-09-03" version="1">MRSDRLASFVATGIHRSYAALRGLPRSYHRNSQPAHAYTATHGSRRFNSDSFVQSVINQVKRDLEKDEKLQEAIKSLEKSKITQKVNRFGEILNRSKDICGHYVSRVSETSSKSRAIQLAITSAKNVVCGINKVAEMIHDEEREVKELRAKWKQRVVNQRQKMDINNAQEGSLGLHDGRKPDDTTTNRIEDALVLSKESAWERFGSRLRDMPFLANFFENPLFEQLFGKSTLATAIRDMKQLDPCFSIPELMELVEHVVAPHIVQCYLTGDVESLKMHCGDVAFNVLSASIRERSLQKLELDHNILILKDVELKGGITMPGSDPWFIFNFTTQQINCLRDYHGNVVAGEVDDIREVVYSMALSRHPDLSQDALEYPYMVHEMAIVGNRPCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0X2</accession>
    <name>A0A061D0X2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone RNA hairpin-binding protein RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0101010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765958.1">
        <property type="nucleotide sequence ID" value="XM_012910504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0X2"/>
    <dbReference type="STRING" id="5866.A0A061D0X2"/>
    <dbReference type="GeneID" id="24562313"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101010"/>
    <dbReference type="OMA" id="RFQVIYR"/>
    <dbReference type="OrthoDB" id="265795at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="4">
        <location>
            <begin position="325"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR93772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="392" mass="42733" checksum="AA4113C5C2919779" modified="2014-09-03" version="1">MTSCRWVDVVSSDSCASFGRTALMKYEMQDRRAAAVTSERLVAAIDAGCVDQLRDDVTDDLDDSFIEREGHVTAMQAGTGVTMDMQLKMNLGDVAIDEMPLSQEDMGESDDSTLSPKPLLKECWDNGAVDVPRDENGVAMVSFTGILGLPRSSKSSGANSRSPSQRDRTSPRPETKSRAPKDVRTGSDSAKHGSGANACTGPVAKDGSDKNVVDSKDAGISTPKTANKAKRAPKDASASKGKTVEFASPCVSPMSMLEAETSKRAKLATDDQSGVYFDDLTQEPLNPPKKPNVMKGKVDTEHISQLLLKQFQQTEPKPKAKEAPNTRICSRLKDIAIGKSTKGYQNYIRKVPIDQRTPCDPQTPNLRENVSAARFQVIYRKWRTALHKYDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D149</accession>
    <name>A0A061D149_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein disulfide isomerase related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766539.1">
        <property type="nucleotide sequence ID" value="XM_012911085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D149"/>
    <dbReference type="STRING" id="5866.A0A061D149"/>
    <dbReference type="GeneID" id="24562894"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106620"/>
    <dbReference type="OMA" id="AIWVVQF"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599926" evidence="1">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="137"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="399" mass="43860" checksum="F06F65DEA05A1377" modified="2014-09-03" version="1">MWFGSLCTLALSCCIMTVRCALYGPSSPVKLLDASSFDDVLRTDGVSLVQFYSEPCAACTSFAKDFEAAATATKDVVGVYAVSDASLSRRYNVRSFPTLKVFLGKGSAEQPIAEDYTGALNVADVVTFTMKHLNKHVKAKVPAPARSKLRPAVKTPSGRVVSLNESEFNSKVLNDNYNQWLIMFFAPWCGHCKALEPEWRRMATIADRVTVGSVDATVNTALAQRYGVKGYPTIVLLPQGPKGPSKAIPYNGARKAEDILAFAKRHYRNMGPPVHVNSFDDLKQRCSGPLCLLFFLPEEGLQGNIDIISKVMENNSTLPFQFCYTLAGSHPVWERALGVSSFPSLLGLNLSKNVFSTMRKEKLTFENVNTYVSEILSGRVIAERLAQSLDSEDVVRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1C6</accession>
    <name>A0A061D1C6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhoptry protein RAP-1c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766624.1">
        <property type="nucleotide sequence ID" value="XM_012911170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1C6"/>
    <dbReference type="STRING" id="5866.A0A061D1C6"/>
    <dbReference type="GeneID" id="24562979"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107368"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107368"/>
    <dbReference type="OrthoDB" id="366419at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004318">
        <property type="entry name" value="RAP-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03085">
        <property type="entry name" value="RAP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600505" description="Rhoptry protein RAP-1c" evidence="2">
        <location>
            <begin position="22"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57579" checksum="0EBAEF217B56961A" modified="2014-09-03" version="1">MIHYACLIIALCALSLRSVAAVRYGQHAMIMAPDHTVQPAVDPVDEDTKQLLEDSEQIEKAMQEEIGLISDESIAEMCLGSKDEHHCASQIAAYVARCKEGNCLTIDAVGKTQNKAHEQLVLPDPYQLHAAFLLFKNCRRNESRHWMNRFWMRFKRGGRYAAYYSFSLNLLRRNLFLGDDENALHGFVQKYFYMTAIYYKTYLSLDAINAKIFNKIALAKHILGPKIKRALRKIVEANKPSALQANDVKAIRPLAYGYRQYMASQIPSLPFFAYRFSSMVVTTLVDNLTGVKQQPWYKRWFGKVKNLFTGKQPSEKAYEIDEPIATEEETEPVEENKSVFGKVKEKLGNIRFNTGIFRKSEPKTRNSHLSEEDIVGSLSSADALLEPVLDVMEKEGEAQNQEAGEPEVTAAPKAPESENGELADQADGASTVASTEMGEEESLEAPKSTQDVMHEDEEQELESDELPAKRKRKASSAGYKKFFKNMLDTGAIKDAASHIKFPKRYFKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Q3</accession>
    <name>A0A061D1Q3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766907.1">
        <property type="nucleotide sequence ID" value="XM_012911453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Q3"/>
    <dbReference type="STRING" id="5866.A0A061D1Q3"/>
    <dbReference type="GeneID" id="24563262"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110190"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="93" mass="10406" checksum="7F32CB238F3B029B" modified="2014-09-03" version="1">MATRRLCELSEARKSLEFRLGITESITYLSEYLAETYVVNFTHDVKDQNKEGWENNDADGNANADAHSAVFLVTTEATTHFSSDQSTNNSAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2N1</accession>
    <name>A0A061D2N1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0106310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766508.1">
        <property type="nucleotide sequence ID" value="XM_012911054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2N1"/>
    <dbReference type="STRING" id="5866.A0A061D2N1"/>
    <dbReference type="GeneID" id="24562863"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106310"/>
    <dbReference type="OMA" id="PNESWYS"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="24325" checksum="5BC345B41F5C6F11" modified="2014-09-03" version="1">MEDFASGFPPPPFFYKNYSFRDVSLSHSVSSAHTLPSVPYTTSLTPHIGDTLGSERISGPECPSAPSDGWYNFGTQEHLAINTVELDSETLIRVSVEDSDVRVHLKALYTDFMDCLLSYLGRIKNMDSDSISDIKRFMKLYSNIQHTLSSFSQRKAEDDVLRMLRDQLQRRRHYIDCLKVALVDIHMLLSKEKADESSGIVDVKGMVPTIGCVPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2R6</accession>
    <name>A0A061D2R6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0200550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767084.1">
        <property type="nucleotide sequence ID" value="XM_012911630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2R6"/>
    <dbReference type="GeneID" id="24563439"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200550"/>
    <dbReference type="OMA" id="HRNTAHM"/>
    <dbReference type="OrthoDB" id="366423at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600549" evidence="4">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="172" mass="19222" checksum="32B31D4DCE29D471" modified="2014-09-03" version="1">MALLRRLAVFASVLLLAENTAAKQLHRNTAHMLEVPSVNNHRQKAYVKPNTMSESRHQTTLSMSSPSSESRNESKEADKAEEAPTVTAEDFIRGRATIEFPAGATYAKIDPQKSLIGAIVIFGIYLVGTMLYNYIRKVTEKKRVEQALRDYEEEKEHYIEYGETVDVAGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2T9</accession>
    <name>A0A061D2T9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RING-H2 finger protein ATL5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767109.1">
        <property type="nucleotide sequence ID" value="XM_012911655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2T9"/>
    <dbReference type="STRING" id="5866.A0A061D2T9"/>
    <dbReference type="GeneID" id="24563464"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200800"/>
    <dbReference type="OrthoDB" id="365379at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="230" mass="25638" checksum="1A61810CAD3E2CB8" modified="2014-09-03" version="1">MLRGLKSHGTSPVVRCVAFLANITSVNADCCLLPIRFDSRDAQDFGRIETCPHTFHFTCIKKWSALETTCPQCKAVFSRIERVKAATGEVVETIECESLFLWDHSDAEGGSDTGGSPDDAERSQQSSSSGAPEGKSKTLRLLAPDQLQEARQPKSTLQWYFTVTVNAERKKPVKIEEAVALTERHLKRTAMNDVCYAPPAVTYEAKPIPVLRRDSEFKLQPVYQEDFIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D304</accession>
    <name>A0A061D304_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767184.1">
        <property type="nucleotide sequence ID" value="XM_012911730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D304"/>
    <dbReference type="GeneID" id="24563539"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201550"/>
    <dbReference type="OMA" id="HEQDLMA"/>
    <dbReference type="OrthoDB" id="367217at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="90" mass="11189" checksum="952C7492822C7A13" modified="2014-09-03" version="1">MISFSRPLLAVRYRNWERSLRRFNRSLRWNLCRWLTRGTYENMKFRKGWKATFVNPQKRALPADSRPVQYCDMDKLHKQDREYRTSLKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D376</accession>
    <name>A0A061D376_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767244.1">
        <property type="nucleotide sequence ID" value="XM_012911790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D376"/>
    <dbReference type="GeneID" id="24563599"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202150"/>
    <dbReference type="OMA" id="WDPTETF"/>
    <dbReference type="OrthoDB" id="359858at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="588" mass="67250" checksum="B79F912540AF34DE" modified="2014-09-03" version="1">MRTQMRGRPPRYSDLSEDYVVGEILEDIECLQIDVAQLEEYDDLNDDTFGDGIGEEWDPSETFLAAEREPVVRRPARKPRELVKCELFDFPEPTRAHRQQNNRNQSQRQNQRRSQNQQSDNSQNTNAARRADRSPRGRRSSDETDEVEHKRSFISDLNRYRRLGMFTLNPRLVELVAAGKRETHHRWRISQRTLERHARGVKRTPENMERELFMDDHAFDQILRIHLAQTCKDPRLQNYTGRWNTRHLGINPPRDAASPGDADPDETQPASPEHKSVVNPNRFGKTSAASVRYGRKLIRLDEVVTSPSSGPVCMERQLRETIELGYEALYTLCDIEEDIEQCPMNHVAALDKMQKERDGKLNQLFLSLTTGNVSVESIMELNKGRVLMIKLGRKLSIETKLQLACCIVDCMPAFARICAAVDEALAGEATLLPLIEVLSSATDMKPLVAFERDDVHTHPTGGVLLQHRLRDANSYTQCFLLIIESLTLTGHLFLLTAETGGRQTALQRCCNILLRWQQACNVFVELLRHRGGVIFMNVLLERIQDSPVAVDKESVDMILHYTLEASEQITAHGDEWRSLASSIMRMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3B9</accession>
    <name>A0A061D3B9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767279.1">
        <property type="nucleotide sequence ID" value="XM_012911825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3B9"/>
    <dbReference type="GeneID" id="24563634"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202500"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="6441" checksum="0F965B3EF68BAF61" modified="2014-09-03" version="1">MIDGDLEGNDVATGAAIDVLLPALAAMTHIPSKCHAQRVEHTVDSCLFQQYGSFFHLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3D0</accession>
    <name>A0A061D3D0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1-phosphatidylinositol 4-kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0202600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767289.1">
        <property type="nucleotide sequence ID" value="XM_012911835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3D0"/>
    <dbReference type="STRING" id="5866.A0A061D3D0"/>
    <dbReference type="GeneID" id="24563644"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202600"/>
    <dbReference type="OMA" id="CFRKSTL"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="816"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1226" mass="137796" checksum="4D1D9C08A688CC06" modified="2014-09-03" version="1">MNAARIADSYLAYKRHNHGICDREDYRDVLPVSERRRTLAILHPEPTADSTSDSGRCEDYGRSVLSCGGGLRIKDLFSRFESDFDVTLDQLTSHIFKHLITNVYAKCSKKRFVKLCRLVCAYLSDLPGCGLTVRRRHGRRRGLSRLRPGLPVSSKGCSRTAIGGKRCILSALRICLYLKGGILGFRLSPKYMMRLVRNVVRHVDIKLGCHSVGWVDVSIIQDGSSNAFPLLKYAANVVANVLCHKAQVVPAHVVLQTSLCLWPPFHPKYTSQMAHILLFMDYVLSEEVKESVVFDFRAAAHESINRWLLSVGSLERPRSKAGTTCGNLYALYAVLNRKHLFQELSGWFIPHIHMVEYMVTSGVMDRTLLSGCAEIRHIKWIVLVCTQLLTSGDDLKHRTWLVIQTMTQFFLEGGVKSGLLRCSLSATCFRCLINFVEICSGFHKILTLLRKSPFYAPHVHLVKMLLKNEMCKLHATFRNPFERLGDVFGVSPEACQMPVPAANRNTSRGHYTPRSVRFAAQLIRKRCLEVASQDEMNPKIRQHRVDTAVAHPVYLKLLCAVDRNVSNVKVTHTVEAVIKGQSRYVILEHLAFRLGRLAWLPHELSTSASIGSALPAPMSMMSHLYLHHYGLDDILSILVVQDHLNVVQRTQACHVLSENMQLVAMMLPQLVQSLSIDPGDRIWHLLSASLKSRMVRERLPYFLACMLHNSEDIITARKAASFLDLIVMGARASGALRQEIRNISMHSNLLNLSSKLATFDVPTRPSVLVEGLRKVNESCATAGKLQVFDDSLEKGAHIIGSRACGTRKRKNVRFLNPQSGKVLTSATRAPFMVDFCLQSDSTIRYIYKMADDMRQDALVVQVKLVLLHIFRLYNLEAYLQPFLVVPYSTALFTLFKMRNKAINRRHSAYATYDMKLSYMRVPRHYTTVLTPCMGNESVESSFYGTAMSHLTESSRFDASTLCGASANISDLDGLSSRHEGEGATPRWFGMSCLRPFHASNALPASIRDIVGRPHILGGIVGFISGTISRHNIGKEYGGTLEDYFLLKFGPRGSPQFDKAMENFVNSLAGYSLLCFLLQVKDRHNGNLLISPAGHILHIDFGFILGASPAADVQFEHAPFKLTKEMTDLLGGVESDNFRRYVRLLVSAYMCVRQESTLLIALVKLLQHSGLPCFRRSSVITLQQRLYLDATPERAAGYMLRKIHTSLHNKTTMVYDMVQAWQQGIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3E8</accession>
    <name>A0A061D3E8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767304.1">
        <property type="nucleotide sequence ID" value="XM_012911850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3E8"/>
    <dbReference type="GeneID" id="24563659"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202750"/>
    <dbReference type="OMA" id="NTQARCL"/>
    <dbReference type="OrthoDB" id="361749at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="199" mass="21852" checksum="FB97B8376344EDAD" modified="2014-09-03" version="1">MILSRTVFRPKAIFPQWLGTRCRQTLYNTQARCLSDRSEAAYSRRIYCNAGNLEFGPPTFTFFTDNACLTMKLRNDENLGYKVMLLTGMTREGGESKVFDKRSRVSSVLPMEEVSKLLEALSHVSDAPITLHGVDGGNLVVTRSSDSVSLKLCPSLIPGLNTTPVSASAGGSSKVHINFMGGSNENALLLHALKELMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3I6</accession>
    <name>A0A061D3I6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Receptor for activated C kinase, RACK protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0203050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767334.1">
        <property type="nucleotide sequence ID" value="XM_012911880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3I6"/>
    <dbReference type="STRING" id="5866.A0A061D3I6"/>
    <dbReference type="GeneID" id="24563689"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203050"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000018">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="322" mass="35488" checksum="545EF849FFDAFD8E" modified="2014-09-03" version="1">MSNNVLEYKGVLTGGHTGWVTSISCPSRSDVNTVVSASRDKKILIWEVYKDEVDGEIGVAKKSLTGHSQAIQDVTMSFDGLFALSGSWDNTLRLWDLVKAKTVRVFNGHTSDVYSVDFSPDNRQIISGSRDKTIKLWNTVSECKRTVSSAHNDWVSCVRFSPNPHEHVFVSGGWDKIVKVWDLATCNLKFSLTGHEGTVACTSISPDGSLCASGGKDGIARLWDMKEGNSLHLLDAGSPINALCFSPCNYWLCVATDKVIKIWNLENKNVLAEIASEKPKKYGLPWCISLCWNPDGTTLFAGSTDGNIYVYQVNKNYNYIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3S3</accession>
    <name>A0A061D3S3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767542.1">
        <property type="nucleotide sequence ID" value="XM_012912088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3S3"/>
    <dbReference type="GeneID" id="24563897"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205140"/>
    <dbReference type="OMA" id="QSDMINI"/>
    <dbReference type="OrthoDB" id="365469at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="903" mass="100939" checksum="F9751E78B07BEAF8" modified="2014-09-03" version="1">MRRNLEDAFWDVRKRRKGKDSRTRNPVLISPPYAYLWGPQPGSACHLSEVSSSSSGFSKVSRSDDSISSVSSSDVTAISLEEGEIDEKNAAFMSEIGVIGTKIDNLVDLERCIYSIKKHVKRLRLLTTLIGVRAAIPNLVDRVLKIIKGCHQTTCVLASTYTLLIKSDKENAVVRMIIEVFSEQFSVITALHARMLNTDSYDGLKWILEAAPYSVDMLITIIPHVVDCTLEVEEHKSLVLLFQALVHSTLLKCCSVADNPEVVVRLSAVRSVFYILMALLPIYPIVLEPTGEALHGDTDTHERSIELFNLMLIDYLRYEDFQPSSLFLFQLQKALGITSPQIGIEGALSLEFIRKITYTIAYIAVIVGCTKRQFPVGYVAASKYGLDEVARAVSSMQTKQHHTKTVGDGITIGDEIQYIWGNAKYWLLSLLEDNSGDVRNTAIRIIRHVVVTIRLGEKDRQHVMSLVTDCVSDAVTLKNAMGVLTAISHLYPLKDGAVRRISNLTLKGSGVRIRTDIIRFIGNCYFTPKGKATTLSVLNNLSEPKKNNETKSMNIQCVTSSIFNNETEIRFAQVEWPEILKTLANLGQKIICIGPSDITFPFAKNLHCSAAHWIGIILGKSQGCGSTVHFIHALLRSEASMRFPEIVNIKMTPSETSTLADSGKIYSDFLRFSKDAVNIDCLKGKVVYLHLHHLRRICRILKIQKAIDAIQNEVKIGTNSDTGKKCQCVDCTTDRIIMSSKHKRTVKSVYDRVSCSAYNLVKDAECKIRQDESLKMKTKRSNIFRAHAVFSYYGNLSQLWTDELEAIDDVDCIAFPSHTGALVVRSVQTNIRDADMLVRIRGPTVMEMGRRKGILSQSFRSQYKQGCAITVKLHITHEIPTVYPIPIKITALLQGSNNRTVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Z5</accession>
    <name>A0A061D3Z5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765885.1">
        <property type="nucleotide sequence ID" value="XM_012910431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562240"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100280"/>
    <dbReference type="OMA" id="CPPELWM"/>
    <dbReference type="OrthoDB" id="365110at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1949"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2502"/>
            <end position="2533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2848" mass="318857" checksum="DE4E483F226FAEF2" modified="2014-09-03" version="1">MPPVEAPDGFYGASAIDSSRMDYSSRTDGTDGVGPLHGLSARAPKGDASNSVLERYSGALDMLRNQLWCMPASGNVTFEEGFAEEESSMGHQSSRSSDPSHLIKVERDLCSQSSVFLKRLLVRADRVPASVIDSVLSDRGVVRRLRKLNDTFTFGKRLYLPHEDLPPEVMSAVNTACGLFNGSCVPAVMWPCTDRNADHNERVTITESAVFEALQIHRLLKHNRGTYVEWGRSATSGHAEAGPLPIDVTDSAAIREVSDTILDELSSTMWCIGFLALHLRSKSDDKLRRHASDLLSDPEELTSRLWKYYLAFSDHVKMRCTHLKDIDKTLNANLSGRLVVEVHRVLSLQCAIVKALLDIHMGTRSMSVSEYERYEAHFERRGFSGAFSAARTVIGADECASSPLLMHAVQELQCLGSLLLSSFYLYDAFGDGKYEVTKKDFLLDTTDLMRKQLMVSGRGPSDNKSSVILVFAYACFLKDLSREKDYRNVDASFASDVAIHVDNYSECLEWIVLTRDMLSVSGSTAVATSSCRLVLLESICRVIECFGIEKLPHLDRIIFCICRIVKGDDSVSDRSYRKAKLWILEHVSSYLMSHFPFGLNALFQLLAACLPHSAESRDDSLMDVDSDCSTMELVVKFLLKPFGTITLSPLITPLEYKADTNEFELSGDVYVGIQLLHMLGFDKQVLFDQWFAWGLGNCLYYLRSGSVGKRVSLNNLRHLSTKQNELLNAHENSWVVDAGMQNIALDSSLGAFWIQESQMPKPSGTSGSLSGCRFELENGMCVTCYTTGKQSASQPEPALHFTLLRAIWIIWRGSMLYVLNMNCDLPDHALRTFVECNALLVRLITKFPRLVSLIEDHIVSSLHMGDASSKFPFGPCSLIFHYTLLFVLCLQRRQLRIMLPEVIEALRGFLIPAYVVPVGDNATEVEFSRYWIFMESFEFCCQGLADEYEAPVFLLMDRIMQEEELPMHIYPVTRGVLLFFKELLEQCPPELWMLSGWHHGMLNMSHTSLDMESNNVTHGLGLSYLSSLKRYVDANAHKSRELYNPFQAKLLCEFFAFVMKDVSPRVAEFEFADNGERLDILCAIADIVQLICRIFRVHNYDNSKSEIGGASTETSDDSWVQGLKELINRCLLILSGSNYIMEVINALTCQVDILAYHQSRSGSLVMVNPLTFIEVSSDFFTVRKAIKSRTAVHITSTAAPDCGYASCYQSACGFRWLCQQEFVSLSGKSKRLISSSLRLLRDLYVVALPRNRNPLFATLAESLGSNYFVNCRTEVERRRRYMQSSDKVFDSNDPVAYYASRQVELLCGGLPVTSVVQSLVAHTYSGSTVAAATDILSMYLLLHEQYKLDSGALLGSFVINNSSALQQLGHMRGNYDVISQSSKDEACLCEHLVCVFLDPTTTSFETRLSIMQYILVVLSTCSGMEMLLRNGIDVEALVDFVDSVLRYHVLHGRRHNLGDVTVAQYALLIFARLVELSKGAHRGYCWRSVTLSLRVLIDLWRSFDSNLFVDPEVALNQQGVVPRSTMVKELWFEQVSPDMYVDMSDSLLERRLGLMRIMGSVYAVLDCMNVQLRCSKSSGRELLDEFLRLLSFVSTNWDFMDTLLPIIVYDSGFVDTYVRNDVTQKNMRQYYRLGLWLGEDSMLPLTRCLHYLHDMNVPPELLLMSGDAPSEINPLDAHELLHSVVSQKLARLKNHVPEKTSRHDFFADMLRPLLSDIVGPPEVNGFENHRPKVNFLDVESPRSDSVHPDYSFYSFGTSSEFGHRYMMDVEMFRHFCMALLTSADDQVNVLLSRGMASVRGCVEMVPYVDSLNELKLRLLSQLCHLVANFRYFGSDLETRMGKLLRADVYACEKDSQRTLKTPMPPFEMFAFNGAMLLQLALTRPDCLSEHPVYVGLLIEFLRLLFEKSFSLSRLESSFVSYYECCRSADASDGGFVDYIVSRDLVGSGDAASGPGDKAKRGKTAKDKPDANANGNRGEVGQDFRLFAVNVLGGLVAQVARCVVEFSERFHEVIDVNFTAPNYSRGFLKLRMAAFRSCLMYRGRIAPKGDPSMSPGAFSDVDTQNSESQDCVCSIAVGKGGGTDSVSVWLHFKLSLFFVWLYKALSVATKSAHEHEPRGVEDGVLEVYERVTKYALKSITQSCVRTIGCMQKENASLLQCFVGGGYGTPHTGEVEAAYVLIMGPYASMLALESIVCTDYNAAFLHGKGYVHLVEVMEAVTQLPYTTSACIANQDVKSGDLVNPMLVMKRDKQIMADSLRSSTGRTFQYANRNMLRAVLYKLMQRLNFMLMRGMTCKEFASRFAASQQLQLLYVYSFLCNFVQPLDDVNPKKMLATFSDNVVSGARGNCVEVIENSLTMWYPPYQGYRVGIAVRCPYHLLHCGMLRFLVEMCSTHDVGGVVDAVHMDSDFGVHSLILDVLRLMHARMSHMMIADKLTLAHLEETHMMFSVLRHLPNRHRLSAGDSALVNELLHYSSRFFSTLMRAFQHGLDKLVDMIPTRSAAELHAEPPKSSRSRITPRSAPSAESSTSERRPGPFQQRCLYLALKIAESFATFLLNLEITVGVDSELPPPLEHFVKTDDPQRIRRMCGVDNAVFQGVLHSTDVDKSKWCPGDHQPLTKPHEVTFEHMVETMGSCVDLCTWSLGVCKDLRIPGNSPFLVGVRRPDSNEVILPLSVFTNFRGEASKTSIEGFPCSIYRESSAPPLDHVDVAPAAIPVSEIQSLVECVIEKTTLYCARAVNTAFVQNQLHQHDLRLGRAHDTAQFDPSGVHSGLNRAEPYGVKRRGGPGRIHSTMRVLHNAFADVAASASCLSASTIEFCAVLSSLVERRVTQARVLSEAFGDTFLYLESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D433</accession>
    <name>A0A061D433_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAR2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0100680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765925.1">
        <property type="nucleotide sequence ID" value="XM_012910471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D433"/>
    <dbReference type="STRING" id="5866.A0A061D433"/>
    <dbReference type="GeneID" id="24562280"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100680"/>
    <dbReference type="OMA" id="MHMDTSY"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="376"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR93739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63552" checksum="B554556A62230566" modified="2014-09-03" version="1">MDVDEPDVIPPGVNLTACLVLNQRDDECLGFDFVSFPGSNEVMGVIDLTPGAHLVYVKDGQPNEEVDRRLGEFLYIEPGTCTVLKRSKLDDGPLFEVASEEETRSYHSGLVAGHFHGKLARVPDELRNLWYDLTQFISVDVIRLLRPIVKKPSSRSTSAQQKTSKAVNDDEQQRLSLPSRASEMSQGAASTSMDEKDSASVRDATIKDHVFNDSQSTMDVDDTSAKSEGCSLSRDGHAEPNIATSSKGLPDTACQNSYPTNCSSADDGEDTAEHYKEILERLNSLKCQPGLLCETFGVIGNGRGRSASSPTDDTKLRADRSKRHNIDADGSSNIPTDSASVANRCDTTLDFEVPRDQCTIYYSDLQKLNRRMKSGMHKCASKITEMHLDTTHILDAIVERHHERDAMLPLSTTDMATSKTSDMAVAEHEYDVESKYSCVLGEYEYAFCVFMLNFHYTSFEHWKSLFRAFCSAESFYMLNTKLSEHLMKVIKLQLETFESDLYEPDNFFAYHLSSLEEIINDNQPQLAGLVDPFNAIKETFKLKFGISFEEATALQDGVQFVDSSLLPNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D458</accession>
    <name>A0A061D458_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767717.1">
        <property type="nucleotide sequence ID" value="XM_012912263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D458"/>
    <dbReference type="GeneID" id="24564072"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206890"/>
    <dbReference type="OMA" id="DWISNAM"/>
    <dbReference type="OrthoDB" id="366074at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="716" mass="79019" checksum="2B32F644DC8C71E6" modified="2014-09-03" version="1">MVSFYELWSRGIDLWVTAVLKDLRRHRKKALLRLLITLARRKGFEAIAKAIIHCRGDRLDPLMALFMRLCELSRFEDATPSDSKSPQSVPKQHGQHASGQRATGKSQVALSATSTLSRCILAAVTPLLLHVFATRSKVPLKSQGLCHCYSAIMADVMQFLDNTGKTVSSRALRCTKSATRSRTTRAFRRTVSAVGICASDKLDRTLLRSRALWSWLRQADPSESASATEIVMRVKASSAGNGHLVDNISGLQAVLVSIANGCNPESSAAVPSSLYQLLEQCPSSHGVIKTRIENAIVYLQRIRSLDLDFKYSRNQMLRDAAKSCAALRQGWDRRSDKPVREPTAWSTIRDNVALQSAMWRNRCLIATSSQGSTAVKTSPRCPPLDDSQVSTVLGCCLLFCGDYLSGFSKICSAVNHAGFGIRVPAHDRLIYLAAGAMACSCPPGEDTGDLPILKLRPPHMVYYTFLRLVGAVSGTRLTAVEPRLLRPSSQLAVQWIVDDVLSSVAEHGTTGAEGRADEVSKDNRSNEVAKLEADRAHREARKGPEAHADAIPKRSAVKSFNGLLANRNAIVASLSESVGRRIYLSEDAALCIMRAHAKIFKVQFDHLREAFTQMHETFTATFNRLNEERGGKGGRESFARYVDDIRAAKVSVEDDSNRSFTRLMAPYALFAYARLVFSQLSLRASNEVFPRAFWLSNRHMALLGHRLRGGLRDAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D462</accession>
    <name>A0A061D462_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765950.1">
        <property type="nucleotide sequence ID" value="XM_012910496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D462"/>
    <dbReference type="STRING" id="5866.A0A061D462"/>
    <dbReference type="GeneID" id="24562305"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100930"/>
    <dbReference type="OMA" id="RYIDCTP"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="294"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="571" mass="63939" checksum="BCAF3FA6C5CD7C05" modified="2014-09-03" version="1">MVLAHRELSIRGVGLKSGDDVRLGFFHFKTLLAYCMMATYSVRNSTPPDAYGACAVDMVNGRSDTADMMEKYKLNYEDCYSKTTGVSNAAVENIPTYIPKYLGPDPFASQQQSGDDICLTDVDSSDEIGDYGCDDAVKYADRMCDFDLAHGDICPDDGAGCAAICDASTLTPTSDTDPTNMDEFNESGEESDAVVESASPAAPVSPECMMGLLSRYIDCTPQLHSTSMRLLMTRESVGSADVIPSQVIRYNNTRLVRYEALRDYLEEEPLFKCLKADISELYNPSSTSASPEETDLPKLLVVLDLDETLVHMHERPNDHYDYMVNIVERDECDALEAKEKGYKTDIFGFTVHSTMHVSLRPGVLEFFDYLRSRSSQFTVALYTAGTRQYANAIIHALDPEYKLISPSVRYFRESCEVSSTPQALRGMPANCIGIGNHHRDEPVPPFYLKKNLQVFDWPLSRVVFFDNSLLSFMNNPENGVWIRPWRGAQPFIDDGRVELATEFAPVKRDGRSLPGQDGLYEFTQVVRLLEELVTERDVRESLRRKFTLCNVVARVLGTEVESNKLDVLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D482</accession>
    <name>A0A061D482_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0207090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767737.1">
        <property type="nucleotide sequence ID" value="XM_012912283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D482"/>
    <dbReference type="STRING" id="5866.A0A061D482"/>
    <dbReference type="GeneID" id="24564092"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207090"/>
    <dbReference type="OMA" id="VCGTHIF"/>
    <dbReference type="OrthoDB" id="387075at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="193"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="580" mass="64841" checksum="B7DB97CFE1B80DA2" modified="2014-09-03" version="1">MDSGCVGDSAEGVSALSSLLSCQSVNPLSLRLHVQGRRLFGSIRHHHAQALLSRIFRTVDGLVEALDDSQLERVSAFLSDVPSDASSFQSFVRRLLGDASESGSIPWLLQNLHGIDGIESFVASLESDWALLSQLTSDPSPDGYAKIARADPECAGAVLRDHRSSVGAVSDDDLAAYTAFSQSDFRQVRLRNFVKIHQVGQGAYGDVWLAEDIVNKVPVALKKLKLNEDREGFPKSAIREIVLLNTLKHRNIVNLLGIAHSRSDGESGKDHVWMVFEYLPFDLSGYIEALRDPSEKRDKLTKPLMWLSIGEIKSIMHQLLRAVSFCHRNNVLHRDLKTANLLMKHDGTIKLADFGLARVCPTGKGMLTNRVVTLWYRPPELLLGSDNYDSGVDMWSVGCIMAELVCGTHIFAADKEPLILKLIAERLGLPTESDLKFLKTLPLWNEPLANPLHPDRQGTIVPRKKEFEKTFKITNELGDEGWDFMRQLFAWTPGNRISARKALQHPWFSVEPLPSGLISRANVKAAHSFMTKNQRKRESQKQPLKRHEYVKYANTGHIRKALEKQRANAQEKQAALNAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4S6</accession>
    <name>A0A061D4S6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">26S proteasome regulatory subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0102790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766140.1">
        <property type="nucleotide sequence ID" value="XM_012910686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4S6"/>
    <dbReference type="STRING" id="5866.A0A061D4S6"/>
    <dbReference type="MEROPS" id="M67.A10"/>
    <dbReference type="GeneID" id="24562495"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102790"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="312" mass="35105" checksum="71BA51D54860A0A5" modified="2014-09-03" version="1">MGDAGRNYHNLLSSFGGTRHAQPYGPLADTSEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTIVVVDVFSMPQSGNSVSVEAVDPVYQTEMKDQLRRTGRPEVVVGWYHSHPGFGCWFSGTDVNTQQSFEQLNPRAVGIVIDPIQSVKGKVVIDCFRLISPHLIMLGHEARQTTSNVGHLNKPTIIALVHGLNRNYYSIVINYRRSVLETQMLLSFNRNKWVDDLRVRDFAQRRADNREIVRNIKNLCERYDESIKQEITSTPDELAVANVGKLNAKLHIENHVSTLLKDNSLDTFGTMLGVEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4W8</accession>
    <name>A0A061D4W8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767278.1">
        <property type="nucleotide sequence ID" value="XM_012911824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4W8"/>
    <dbReference type="GeneID" id="24563633"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202490"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="7815" checksum="927437170B0B4681" modified="2014-09-03" version="1">MIDGDLEGNDVATGAAIDVLLPALAAMTHIPSKCHAQRVEHTVDSCPFQQYGSFFHLTALPWFAKKAYCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5F2</accession>
    <name>A0A061D5F2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767448.1">
        <property type="nucleotide sequence ID" value="XM_012911994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5F2"/>
    <dbReference type="GeneID" id="24563803"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204200"/>
    <dbReference type="OrthoDB" id="366608at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="36196" checksum="D374C126B6C1194E" modified="2014-09-03" version="1">MVFHSLTDAPRDFREGIDWLVALKGTDFKNNLKAISDAVYNFLADKPVGSSKLPIFKYVTLITKEFLEQDGLKDHKPVKLMLTRFNSPKDEKPNVCAMLLKADGDRDHTQIADEWRLNAKNIAENLAKTVNGCEKFLQNVRIPHQYESAYSSEATWEKSCSEKPEDCAAVFVGIAPMLYTGLMSLLHSTDDSLFRLAPDMAKKKLETLLNTLRYVKPECRAIMGPSDVAQVLSVVDHDALATLGELSNFWTYHGLDSAGVAEALKYYHSKYGSYPITGGDNGVNMGLVNAWNSKLAKKPAKTGNALGSDNIYYPGVPTVANLNAASPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5S8</accession>
    <name>A0A061D5S8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768094.1">
        <property type="nucleotide sequence ID" value="XM_012912640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5S8"/>
    <dbReference type="GeneID" id="24564449"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210610"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="144" mass="16212" checksum="E3F013DDBF18C530" modified="2014-09-03" version="1">MVAPLLHALGFEAQRTEARRAARLPDDLHRLVEGVAARQRDYVLVHRAADARLSVHVLYVAAQLASIAKKRPPCWNTATAQGIAIEACLPTFAAADDQAPRTPRELRRMTRAHTHSVPPKPVRRLRILRPHRQTRRPQPLIVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5T3</accession>
    <name>A0A061D5T3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767553.1">
        <property type="nucleotide sequence ID" value="XM_012912099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5T3"/>
    <dbReference type="GeneID" id="24563908"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205250"/>
    <dbReference type="OrthoDB" id="10526669at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="136" mass="15616" checksum="685F422621054E30" modified="2014-09-03" version="1">MNEFVYIFIVFAHFVMNVWHTLPHHVQRVCPRDCEDKDPVHMIKGLILECFFGSNVLLNFGALGYSECRVNLIRGDSDVARFIIQVQIRNLRKILTIAANRFPARLHIQLSELVGIAKPIALQVVKYNTNLWSVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5V8</accession>
    <name>A0A061D5V8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ser/Arg-rich splicing factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0106030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766480.1">
        <property type="nucleotide sequence ID" value="XM_012911026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5V8"/>
    <dbReference type="STRING" id="5866.A0A061D5V8"/>
    <dbReference type="GeneID" id="24562835"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106030"/>
    <dbReference type="OMA" id="AMYSLDR"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="231" mass="27870" checksum="8B4494C14271E671" modified="2014-09-03" version="1">MGSRERHDRRHASLLVRNLKYETSPEQLRSAFSKFGEIRDVYLPLDYYTRKPRGFGFVEFFSHSDADEAMREMFGYELDGNKIEVFVAKHGRSDPYQMVSQDAGSRRFIRKPRRSEAMIHSKTEEQAPAVTCHKTELTALQRNRERRRRRSRDRSYSRDRRRRSVSYDRHRRRSISRSRERYRSRERDRRMSRSMDRPSPRMRGDSRGRNHDSPKRSDGARDYSRSQSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5W8</accession>
    <name>A0A061D5W8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superoxide dismutase</fullName>
            <ecNumber evidence="8">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0300160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="8"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768297.1">
        <property type="nucleotide sequence ID" value="XM_012912843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5W8"/>
    <dbReference type="STRING" id="5866.A0A061D5W8"/>
    <dbReference type="GeneID" id="24564652"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300160"/>
    <dbReference type="OMA" id="EETIRYH"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF3">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [FE] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="10">
        <location>
            <begin position="99"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="25093" checksum="A3F30C0653BEAC60" modified="2014-09-03" version="1">MYVRILRTHITSTKALNALEPHISEETIRYHYLKHHAGYVKKLNELAVKQPEIATKTLDELLETAQGTVYNMAAQVWNHDFYWLGMSPNGSIADAPMTNELINKTFGSHEALKQQITQMATGNIRFMPTNNNAAHFGSGWVWATYDRVTDTLKLAATKDADNPIRLWMVKPVLVIDVWEHAYYIDYRNDKSKYTDAWFKVINWERAEQLIQKYRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D676</accession>
    <name>A0A061D676_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766615.1">
        <property type="nucleotide sequence ID" value="XM_012911161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D676"/>
    <dbReference type="GeneID" id="24562970"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107353"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107353"/>
    <dbReference type="OMA" id="CIANMLG"/>
    <dbReference type="OrthoDB" id="365506at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="271" mass="30486" checksum="5845DBB67577FE79" modified="2014-09-03" version="1">MSYNDELVLARAFLNYSRGVSMTLDGVRNKYESNGNAMHVSFPDDPRRCPMVPFVGIPQASASGIEVKRRRYQVDAVVFRMLIESSGRLFSSYVESFMECLVEAEGHIVALTSKHENTKDLRIDLNRDSDACTACSGWLEFLLGGFWGFRPKVPHKTTDTIALAVVYMRGLASWLCIANMLGYTDTHIQQVAKEFVAQCVSLSKAVGTVRRYSMPTHFSNTLDIVTYVINVSLKQMSVYADAMLYSTFDVDFDTFRLLEKIYKPGVKSTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6A2</accession>
    <name>A0A061D6A2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyubiquitin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0107570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766645.1">
        <property type="nucleotide sequence ID" value="XM_012911191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6A2"/>
    <dbReference type="STRING" id="5866.A0A061D6A2"/>
    <dbReference type="GeneID" id="24563000"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107570"/>
    <dbReference type="OMA" id="MSDEHTL"/>
    <dbReference type="OrthoDB" id="363244at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="155" mass="17459" checksum="12C289917AEDD559" modified="2014-09-03" version="1">MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6E8</accession>
    <name>A0A061D6E8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766695.1">
        <property type="nucleotide sequence ID" value="XM_012911241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6E8"/>
    <dbReference type="GeneID" id="24563050"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108070"/>
    <dbReference type="OrthoDB" id="10675672at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="421" mass="46837" checksum="C26B0645D8BB0322" modified="2014-09-03" version="1">MAVSAAENEQTYQAVSDYTGCNGHAKHDEDGNEGMLMDISEMKATLKDIREMMESLKDMREMKATLKDMREMMKSLNDKKETKEIAETMKSLLDLLQRGALHKEVVAPCVLKTPHSDGGTGTSPSGGGQQQLCSAPPQSQHASSQAQSVNIPETCVVKKSPNLTAHQQVVYNSLIYVPRNFKEAVDWLIAVRGDDGMKHLKALGAALYDFYAHMSGRFTEVSDLDKVIRVSREFLEQEKLKKRRSVKRILIKLNDRLRKTPDQLAKDIGSADDTEKEKYLQTKGLTADTIAEKLCCVVDACAEFLGRIKNRSHYKSAYSPQATSDASFSAHPETGVVIFVGIAPMLCASILALEMASFRAVLRLPPFIAYKRMQELIQALGYVEPECRAGMTASYVVDALGDFESETTDFIYRLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D726</accession>
    <name>A0A061D726_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768499.1">
        <property type="nucleotide sequence ID" value="XM_012913045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D726"/>
    <dbReference type="GeneID" id="24564854"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302170"/>
    <dbReference type="OMA" id="IVTKYDP"/>
    <dbReference type="OrthoDB" id="361154at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27699" checksum="235B6883897DD03F" modified="2014-09-03" version="1">MAHDTHTTCPDLGAFIVSKYDPLLTIVKELNENLQHLERENLRLERRIVNLEQYIAGAQAADVVYTLEEESALSPPWLFSCQYTHRTDWHRNLNVASTLGVQSIKHDGIGCLAENMWIAFMEEIPAMCNIKVDLKEMVDLQSMRRIARRVLMELSQNEAMVVLRNVPGKDEATTNATTITLVAILASAIAEAWKRVEYTTPQNMGRVCLILEGRRKCRQTHKAGENIGSRLRAGTKKFRIEPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D748</accession>
    <name>A0A061D748_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0209450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767978.1">
        <property type="nucleotide sequence ID" value="XM_012912524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D748"/>
    <dbReference type="STRING" id="5866.A0A061D748"/>
    <dbReference type="GeneID" id="24564333"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209450"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="33541" checksum="0ADCCAE1C25D2A43" modified="2014-09-03" version="1">MALLPRFRFGSSAASLLRGDAGVAPVQRRCFGSGDMQAVAIRIKSVKSIQKITKAMKMVAASKLKADQRRLEAGLPFSTPTQNVMNLLPISTTEPAGKNTALVVLASDKGLCGGINSAVAKMTKGLVAGGEAGGAAFSLYCVGEKVRSALETAYGKYFKSVFTEVSRTPFNYAKAAMISEALRQGNHDRIRIVYNHFKSAISYETRTLDVLSLPQFKAMHKRELNVYESEPEMAEFFPDFYEFYLTCCVYGCMLDSLAAEQSARMSAMDNASTNASDMLQSLTLKYNRARQSKITLELIEIIGGANAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7A9</accession>
    <name>A0A061D7A9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768782.1">
        <property type="nucleotide sequence ID" value="XM_012913328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7A9"/>
    <dbReference type="GeneID" id="24565137"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304990"/>
    <dbReference type="OrthoDB" id="122464at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="21137" checksum="2B0B93CD0525F1E3" modified="2014-09-03" version="1">MGRDTGYFRAKYQIGQTIRPEPRADTDYRHEPAAEEFYSSDQDDADAEFVRDTFGESRGGVFRRRALLPRVFHPYMLQVSDVSDPGGCRCHVPAETPPATSNPKRRMALAQSMRFPQTTCSVTSAALTTERCRMTVTWRGAMSVDMSLPLWTTKAPITSDGSSPVRRERATPAVGVAAACTLISYHPKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7E5</accession>
    <name>A0A061D7E5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768088.1">
        <property type="nucleotide sequence ID" value="XM_012912634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7E5"/>
    <dbReference type="STRING" id="5866.A0A061D7E5"/>
    <dbReference type="GeneID" id="24564443"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210550"/>
    <dbReference type="OMA" id="IQGPECA"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16200" checksum="61124B70425BEC72" modified="2014-09-03" version="1">MQWESRFAEAFLCSDIPKIGTIQGPECANIYQSLGLSLTRDQIKSCGAMNKEQFVKKGMEIVSEQFVKKGMEIVSEQPSGGDLKRLFEAVQNSQTKTIGTAELQEVMGLMKNRSPQDLTRLIDLLDPEKTGRITYEKFVDVFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H7</accession>
    <name>A0A061D7H7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768123.1">
        <property type="nucleotide sequence ID" value="XM_012912669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7H7"/>
    <dbReference type="STRING" id="5866.A0A061D7H7"/>
    <dbReference type="GeneID" id="24564478"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210870"/>
    <dbReference type="OMA" id="HEQYISP"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="349"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115698" checksum="A50A124DDC9E61B6" modified="2014-09-03" version="1">MLRSAYSPRAKETRDSSKPVHEMASQGLKTVHLTKPGCEMRPLASIHGDEIGIRDKEKESGYMGSSMSTSPGSFQMQTTPTLDVHSPASSTENCCHYTCWDGFTDSLETHRFSAECMHGCSPPCEAPNGFIKGGKSFMSAETVFTCDKGSCDGFGKVDKGLSPRVVGGVETTEPSDAISSDISPTCYDSCSDCTVSKLATGRVRSPCNGDSSSASGSPTGAGEYGYTSSVKSVDSHLAEVEVDGKSVVENEDRSVQRNVCRKPFRHVSHLTPENWGETEDNAISPCIELQRLPLTMQNGYELRGGHLVSWSSVPKTGSDAESNVEWSATEMRHLLETVASAMVSTEYVLNSLVERITPTRTCRANKLYLFNVLKRFIKYCLGDDAHVYIAGSTANDIDIDYCNLLSVPFYSDLDIDVISSRYGSNAMTILRQIFHNLCESQAVLKGAGMVSNWTIGRSAFKLVDSARVPIIIIRTKNGMLCDVSVNAANSLKHNKLFHEYIEKYPIMRSLMRLIKHWLKFRGIPATKEGGFPTILWMFLFCNAFDTGDTYTIGSATHARNVSAMCEMLLSREILRGDIASVPLTHISLLAALEKTFRTLAEGNNLIEMVNAATAYGRVQDAVNRTKPTRWSMGEIGRKLVELIDVEPHVPFATWLVYYYEICRTEESLSKYMECIETLVSLSICLRVYEALGNPDNINAMLEIRALIVQVKHVFGYNLFYLLHESRPVVENVQRYVQRTAHMLRIKPDTPDMMECTRMLINHVSEQLSTIVTGVFYESYDKVYSIPASIEPPSPLMPKAQRDTHDSSCSTPYMDGGIWSDTGWLIVALEGKLHIVKAFKVCVKWDSWWSTYFVSRRDSKAVFHGFTYRQVSVAGRGDRKPDSELPRVLIRQGALELFHPCDIVSRLYVVKVMKGEQSISSHYYSLDMFTGTRTLYVLPGFEVARFEQLCRVSARLLASAGPDAFRTIPRPDKCRHCGAITVPGRFVPNELKTSQRKRKNLRHLLICPRYNEYYRHMQASLWRVERSIRRQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J3</accession>
    <name>A0A061D7J3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0100240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765881.1">
        <property type="nucleotide sequence ID" value="XM_012910427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7J3"/>
    <dbReference type="STRING" id="5866.A0A061D7J3"/>
    <dbReference type="GeneID" id="24562236"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100240"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="269" mass="29214" checksum="0492D983B0ADDEB1" modified="2014-09-03" version="1">MAERGGFSSGFGRGRGGRRASSRGRGGNEDDLKSWVPVTKLGRLVSAGLIQSIEQIYLHSIPIKEYQIIDYFYQPTLTDKKLADDVVKIIPVQKQTNAGQRTRFKVFVAIGDFDGHCGLGTKCAKEVATAIRGAIISAKLSLIPVRRGYWGNMIGEPHTVPMKVSGKCGSVRARLVPAPRGTQIVGAPTTKKLLAFAGVKDCFSCSSGSTKTRGNFLKAVFAALSATYGYLTPDLWRQVKLQPSIYEEFASFLNSGKTLVKPDTVPYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7M7</accession>
    <name>A0A061D7M7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0304510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768734.1">
        <property type="nucleotide sequence ID" value="XM_012913280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7M7"/>
    <dbReference type="STRING" id="5866.A0A061D7M7"/>
    <dbReference type="GeneID" id="24565089"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304510"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="6049624at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000004">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="447" mass="49546" checksum="5D91D324331C753D" modified="2014-09-03" version="1">MREVISIHVGQAGIQVGNACWELFCLEHGIQPDGHMPADKQIQGDDAFSTFFSETGAGKHVPRCLFVDLEPTVVDEVRTGTYRHLFHPEQLITGKEDAANNFARGHYTVGKDIVDSCLDRIRKLADNCTGLQGFLMFNAVGGGTGSGLGCLMLERLSVDYGKKSKLNFCCWPSPRVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAIYDICKRNLDIGRPTYTNLNRLIAQVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPANMMAKCDPRHGKYMASCILYRGDVVPKDVNAAVAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVMRAVCMISNSTAIAEVFSRMDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGLDTTYNEDGENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7P0</accession>
    <name>A0A061D7P0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767100.1">
        <property type="nucleotide sequence ID" value="XM_012911646.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7P0"/>
    <dbReference type="GeneID" id="24563455"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200710"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1568"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1588"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1603"/>
            <end position="1615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1615" mass="178272" checksum="533908224FA4CE58" modified="2014-09-03" version="1">MAAQSSVPTFNTLKECLEFLEWLHSDKHGKGMQGLVAHRLDKFLKDRYSSVDHKQIEISLSQFLTHVSKFYNKLCTSPNGSYTGNKSAKNVTNALLNCVPKLLSSLYFLRYNVDVNFEALGGGKWAKEQVGMIALFSRIFTQPDQLMKRATKIDKYLITQKGGDYGVVPGGFAVGELKEGYQGGYAEGSLMTDNLKSILNKATNIQNYFLDVYATTVLATSGTQTSNVANALRLVQDFCKIFEKVEERDFGNHLYTKDRCINLDDLKEHCTKLIGTLSKLFNQKAYSFTGYAREYNKLRTQDISKKMASWFKRNLEAVKTQLMKIKSIGSSKQINKKSFRRSAVVPAQSQALADYFTQHFLPYGFTFHGYDFKKWGNPHEVLTTDWDGVINGLRSANDGLEKLKKILEGDHCPTVRPDDDEEAKEEPEDVELVDEGSGLMPKKVEPPPAKVPEAPKEVVPKNKTAPDTGPNTEVTKTEAAKPVTTKADGTPNQGKKAEGAQNQGKKAEGAQNQGKGRSAEKSPSSDSSPSGASVPGSGPGPGGQAASVDSGQRSGRDGQRDVNADTSSVTSAGRNGQQSTSVKFGKYSPPQDVLDRAKAREIRLQNYEQQKQAEEEVNRKHKDNLLKRYNRLQQYQDALPYVDGENAVQAYPVTFPEPLDGSVVHPDADPRHQYSSRFENIYKTYHDMYGNNLRDNVFTGMPTADSKGLPGSMRANFSAFNATPVGYAITQHKLPNVPPSVSQAVDFIVKPVPDHRLAPLLSPPLIIGDSVVSPRQYTEHDPAVPTQLDPAFKNISIGGSEAIPQSVTTDYIQSALVDSDLSVFEPIKTKNLTAKHDHAVTKLPVTVTLDDILPAPIANTLPHVSVSKHYPRGHQRDATESQMEPVRHTPTLDFKGRPVPHPKLIHPHSPAHTIHKPFPSPSEPIESYSPTSHPHDNSVTALDLSMSGSVIPMTPFPGVHNIELSIPQKPKVQVIPNPKQRSLLPPIALPEYSGHQYYIPSKYPFIAKVDDQTIEKMLSLTGTPSELQTTQIVGDSNVATLAIPELTGNIISAFRQDPRTSRFPPTSKPYGDDDDDDDDDDDDDDDDDDDDASVEYASAVTFNDNIMKTMAGVAGHPVVGTNGQVDISQIPTAIPLDAGDIHHLEGQELEDSFTIKRQEQDLLNFQNEELKQDSQNAQRERKLLALKQESEHINDKQKELMQAAQVDADRIRAFKDSQFDISSAPAPRVEDPNIDFSIQTFHYEDRSINDVDLDDPYANTADILKYELKPSDDKGFSGLPNTNFNLDFAPERIGLEGYDDPGMPRDSPREADERVITPFGRDECLNPWSVSTSTSSTDIINPPPSPVPVTDHLPPPKTVREMLHWFVGLSQYGFIRVIGEHFKSILMDINKDASELSDALEVTGDPDQLTASMVTAKLTEACLYAATVIYKIKHNNDFKAFSTFDFKYEYSRLRYSSDPACLLCQLCDYVYACCHQLEFLKSQCERDKLSGGWQDCKYGSDIKTPSPLHSFLTDGWDSDFETHPFDPCNLCHKSRVRMGFGESDLPKIQQTGTTLSSILTPSCGGDDFGRRGIPHPVEGPDAEVAHDADDEDDEGDGGDDVRGGGGGGGRLSVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Q2</accession>
    <name>A0A061D7Q2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767115.1">
        <property type="nucleotide sequence ID" value="XM_012911661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Q2"/>
    <dbReference type="STRING" id="5866.A0A061D7Q2"/>
    <dbReference type="GeneID" id="24563470"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200860"/>
    <dbReference type="OMA" id="NDLIYEC"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="946"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1140" mass="126150" checksum="5322431E24E060DA" modified="2014-09-03" version="1">MDEGQLIEALPRLEKAKDDANVLYRERRFKAAAQAYTQLVAEILAVEPSAANVAALSAAAKEASVKDENVSRLLATLLSNAALCYYQEQSIDKASELWEACLSVDAYNYKAAYNLAQCHVARKELKKALELVARCQNIALTKGMNNTKSLPHAELMQRIGSTVERDYDERQGYSGNDAIFAALESGQSVRDNLEKLSMQSRTETARNRVIPRLIKVIKGATDVVKHASTHADTWGTIHVLLQDVGSATEAELLSQLSSGLSEHSLDLVSYGKEVMKCIENNRSAAKSLYAVAFQFGRVCYHLGSTASLEALCSIVERVEPELEQRIYSCVYQYFSRPRHDEKRAVDGHFSTVLSRLLETMLGQCELGCPNERRDTIERVLVSIFVMAPTRFAISEETLNGVITRLLSAYVAFAPDPALSNCLLQSQWYMAMRCLHVSNKSLFKEYMLTGGLVPPLIGNFMIVGWEEASMSQLRLFSSEVIVFCMDYMELRQQVVETKVNEQTLVEFLRHDVGFAKFLGKLVERDGEIEEYCRKGKFEFKSPLISDMERSLHEFKLLILSKLAVHSTEVMRQICDAFEVMGMVPLAIVANLIDGYRVDLLIDSLSFLTLHGEAKEDVVVDMLLPVLRWSESSADCKDRTFYMVCQTLANLTRSRSHRDNFNRDPSTGAMYDEAQISALREAYEKLPAASRPKSNGEYDEGSEELAERSRKAILSLHDDVPGLLINLARKASPDNAETDSSESGKSGSASRYDSAAYLVILETLHNVTAPRATRGKMHTAGALRFFLNAASNSAHQKSKRSRYFTQSVAQICMSSDPRNLSYRDALDACGLLVKLLRDDSELLQYEAALGLTNLLAVDDSVRQRVWKVGGWDALGALLSSDNALLKAAGLEGWCNFANDSGCVTSHIYSKLSDLLDDEERRIRKESEAENPADSAGDGGSDDEEGDQTTDANVKTTASDVQTTDANVKTTASDVQTTDSDNQATDNDAQTTDTDKAEEAAASSDCLKKVPILQMHDINVMLMFAADTSDLRCAKASTGALAHLSNDVRVAGYLPLCSKFDRLIVAADSLEDRDALQRVFTIFNHVQQGHEVGESAAREYVAKVKRDIRACTERNMPKMKACGLLDLAEEVLRHSDITDNSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U0</accession>
    <name>A0A061D7U0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate 5-kinase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0101090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765966.1">
        <property type="nucleotide sequence ID" value="XM_012910512.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7U0"/>
    <dbReference type="GeneID" id="24562321"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101090"/>
    <dbReference type="OMA" id="NHQLHFE"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="1597"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2038" mass="226773" checksum="9A1274ED15FFF06D" modified="2014-09-03" version="1">MQGSLRYSCYVSAFEDGLCMQLKCSRRRNHPSCQKKATRPQATAYATRRRNRVLKHGSKRSRDSDPRRIDHEEHESGPSEPDTSWHGAVFGDGCTYWHTELLQLVEKYIKRNLRHDNGGLHLGRAYLDHLSSLLLRCVFRAKLQHVHRDIDEVVKVLQVPPTLHTALNIEGRHGFAVFPGICFRGHLAHPRMCRNLEGCDVLLLKSLLSRTVTDLSLEYNDIRDFGGVLGCVDVQVERLCSAGVKLVLCSGSMSAEISQKFHMRGISCVSNVDFDVLSQLALALARPLVDSLDKCFEISKHVGRIDSFQFVQKSGESVAAISVNANFHGCTILYSTSRLTWANSIRLKELFSTALFRLQGVFEELMFVKDLGGSLDVGNATCFHLESARGILSRRSSISMGAEPTLQRRNSLSYVRSPCSVISAGDSNPTPRSTLTGSVVYSRRNPKCRSKRFRDIVRGSQRIDIFKWDSHRRINGHQVHLHFSDWLSQHLLGVLVLPTAVEDQGDPGGNLKEQSILHCFEYFTKFSEICGSVTRRTVPVGRYTAGSFVSDFVLAYARHLRRDNCLSSESCSEQLSRHVMHLETSNAVAPVQHKRLRVLVDNRDTGLRPAESGCTFFIHTHCRSCGKADILPVNDLTFGRFVHLLLYNRCYTSRCGHNLFGGHDFSLRAERFTLYMQVEDITNYQIGAWFDSQLLNCGMGFMPLSSAGMSLHNRRLLQVSSKLLKVFEDYSDVDLDTNFESSDAVCRDTPRGPASPRPPTPDFNWEPYDEQEMDMLYLKDRSSMLGLALRNLFKMLKACLRSRFVACASTVRLEDVLPCRCELGGNSSSRKLDNRNQWSSEFVMKSMQHLMQLFEERNAFGLYLHPLLLDGVGAAFGGAGSFGFCGRCQKAKFSSIADIEILNWIYIFTGVVRCLGVKLHNLSSALRQSLTPQKSSDINSSSQAVALSTTEHERASSVYNRVIGKTVDAIDDCLEGIRSIYEQCVSHLLFAQLWCPLDPLHLLMTVRSFFVALTSLCRSTVRVISRVPGWALLKTMRFIDTGTIVVALKTTDCVGSVESGSSHGSNGALRTQSAGNDESETRKGVGVNGQSGGEANGGPSTTGTDDHNEVHHEVCDSDPSRPHIVRHGEGATQSYASARLTHGGDPPDPHRHIKDGFYTVWGAQIRPQRLVQSSGNQQMRDADEPSVNALSGSGVATSCTDANRNYTLPHFIHYALNTSITAGFVGQSDEWFGSPSSLWHMLSRMRIGCPKRMSSVVSLSYGIVHNLRRDVCNVISAAIMSPEYLEQCSSHFQGPVSANLCSMGKCLLNYCKNQNYSIMANISCGPHRDDIFGVSVEGSHSAVSAQANRRHGGLLMDSLVLRYLKRHSHLISFLVNSADCAVRLREIEMDGALVVRRWDDLHSSLPSSPWCSMAGSASELSCANLLCFWKSLRVIGDDPLLCVSKDSASVFCPITRPCYGTPIVCCSNRLSRYQWSKHEKVFGQVPVMDHAIKLLRGNMASKRDVLRTVVDWTCRQLESACYQRSRTHAMVAYVESQVGFICNREFCRVQVTGDAELPLAAFTVEPFAPGGYTPCSPFFQESPCIGLSPGRQYFTLSSFSSRDGDYVGLIRGTSAVEPVVPMPAAKVGGAFERHRVPAGKDLSRCTFITLTSAHTNCDVTLHYPEAFHSLRHLSCGDDTSFARSLCRSSRLRCSGGKSGAPLFVSHDGKFILKLLNKYEFQLFVDSGARFFEHVLGGGTLLSIPLGLFSIRYRSSGNTVRCLVMQNVDHVLLSHKLTFDLKGISFKRCVNLSPNKHSSTAFTASGRPTLLYDNTSEESADVPNQVVLLDQNFKDFTNGCPIRLEESSLLRILDFVQRDLTFLSQLDVVDYSLLLRLYPAEGVVVLGIIDYLRPYTWDKQIETIGKKLANIAIGQEPTIVSPVEYRSRFMRFFSRIFWLSPEVEERAPTPVRVPKPVRRAPPVCRCTVCAALASLYTTPYVTSLSHYMLGTSPLAKRYLRSLIASSTPCMSTAEAAYELAKLLRTIYDDAVLDVRYSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D869</accession>
    <name>A0A061D869_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THO2 PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0300870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768368.1">
        <property type="nucleotide sequence ID" value="XM_012912914.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D869"/>
    <dbReference type="GeneID" id="24564723"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300870"/>
    <dbReference type="OMA" id="IFALECD"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="4">
        <location>
            <begin position="554"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1342" mass="151169" checksum="4114D160ABC0C0C0" modified="2014-09-03" version="1">MGRSVEPGAVANKRRRTSDTAQNINDDNVAVSVNRDSISDQEVTPVNRAPKASPDSDARGDSGDRLFDLVRNVANGVLPSSSAAEGLRKKFPDAAPNSPVSFRILDCIGYLLEYSNFRHNLEAFLASLESVGLLTARSIVAAIDAYKLDGCGYSAGLTTIAIRERTRNQFVLKSYALWRECTVGFDLLQQLLYHQEWDAGDLLEMGQLRDSVKYIAGQYSLCPTRVLYELIAWSSWHDGDGLMLLLQQYPKGRVDEVVRLMLTQKCMLKQEYQTVKKQYWRIPSTLGLYFPKLCARLLAEGILDLSTLYPYLEPADADLSNLGFHFLSVSKRMPNKLDRNETPVTYLIPLANCSYGDNAPRQMLDMASAEKLYTSVTLDSTTITSARELIHARHAKVMEHLRASSTAATSPNSFGMAAWNPSDRFRRNESVSSVTSSSGVSNLLHKAEHRHSATGNIDVVKYNLLDSDGYAYVKDHIFALECDKLSVLSHLFDIARDLESPAWILGKLMLDHIQVTAKFPVVLHGSICKAMCNLILRLIKKHTKTNDWRRGIDQIDRVLRILGPGLHINLVCFSATIKFLQNCIEKHIDRVCRIVWRYLLPALCMVVEGNCQVADRLWNLLSNIPASKRYRIYNLYLSRVLDSRSTTVDAWACMVRASYNCALVKTRSIFKRVTATMLKTTKSASVRGNVSTVCGLSAVDPFAVAHTIVSQCEMFENLVLPLSEVGKYFGHLACDVFFFKLTANQNQVCFRCTAEVDDVGRSKRLLVNAQLASRFFRRHMDVDLAPLLVGALTIIQRSMMINQFDIVPRSSEEGGDIPMEFSKRSIKLKPIDTGSRLAYPHELSNGWLALEYVSKLLELVGGVPQLAEAHALTIDQLNAQGGGVFLRSEIMTQDPDDETCGMSSRENLAKIMLRPFFSHSLLFLCGKMRQEVMYDSEFRAGVVYLCATVDHLQKMALQFVEFREAVDIIVNRGLGSESFTLQFSFPSFDELRRFWDEANALYFSHSCTNPPASHSSALSHTAFKPQFLEFVNNIHLRDIWVPIEQYQKTLQRLEGWIKDIGSAHSSGSHRRLKKLRSRYQALEREVKQQEEHVANTKLRFEEAISSGWLTAEAQIGPGVTIAFLKHCIVPRVFVNEAEAAFCGRLVDLMLHYRLECFNFFDFSNCWTKMLMSMVRCCTEREAPLLAIFVNHMFGVIREWSSNAELFEGMTQGHPCFCTTFKYVPDKALTHQQLLGGIRKWEGRIIRALSYALTLHIPESDGGLSKSDSLVSAPTWIDQKGAVVFLARCHESFPITCTAGKRVLTGLRCVVESAQRQGWKDVVAAASTLLKTFEKYERTNKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8C3</accession>
    <name>A0A061D8C3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769127.1">
        <property type="nucleotide sequence ID" value="XM_012913673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8C3"/>
    <dbReference type="GeneID" id="24565482"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308450"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="712" mass="79083" checksum="00F1D74DA1CB68D9" modified="2014-09-03" version="1">MDEDVQRIINEITEGVTDKTYLIEEDAKTLTKKSEELDDLIRSTKEKLGSLVQKTLNEVVILDRAVKDCLNQVKGGLLMAFGEYVKKNLLSTIKGQIIQITKTTGLEGVRQRLVEEYSGHFKNDFKQVVIGWIEEILSDNMVVKDYFGQYVKMNKGLNVKFKEEYIDTEHDSIKVGETEYVANAIVNHLKTSVGITMAEAKVSRDDKDKIHTNIKAVEDCITAFVATLDEKIKEKNSIFLDSSALVIGLANAINTSVVRITHKDISANFLRSAVAAILAALSGKANQVLSELEAFAGIEASEIAKVDAALGVAESLNENLRRATNSKTKEAGATGFYNVDEHVDTILDAEIGESDPGDGKVKLEGVLSFARYRRSITLDAKLKSNPTGTKEEGQLPESIGAIKEEAAGIFIGHITSGLTALSDKIKQDLDTITRAITASANVVKDNLLKFRDDKIGNAAKYTAIKPNTLQKIHENFEELRDPVAKALDGATDLLDKFLAGADKHYTQIISDHVKKDIQKATNKLTTHARKRYVESIKFLLTEFARKVRTELRDLPREIDADLKIGFKGFMKDFHVPLTNDLSSDDYTVHKLSYAFKLCFGPWQMLLEREIDRVDKEERKRKNRTPAVSEVTYTKRLKSVFGALDEVLMHFTGKNGYDRDTHGKLDNLEAAIVGLKPQDFAKQNTGILDSIAAQSLLAAARVGRLAKITYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D3</accession>
    <name>A0A061D8D3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768964.1">
        <property type="nucleotide sequence ID" value="XM_012913510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8D3"/>
    <dbReference type="STRING" id="5866.A0A061D8D3"/>
    <dbReference type="GeneID" id="24565319"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306820"/>
    <dbReference type="OMA" id="LYYYPDH"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="436" mass="48926" checksum="02617A581DAEB609" modified="2014-09-03" version="1">MSNVSTIFVFDVNRAPSSPNPTDEEVQDAKLLYYYPDHREVEERRSHLGLIEGLLVLLASFTKHKIDFLRTKLFTTTISEWCDGIYLVVCFKNEENSWNEMAEYSHHWKHYMTKVVLENAKKLFELLHGPLRDLLNASDGNASSNLESVRRAFEDFLPSFITKAAGDSFNILNAWNASYKSHASALSTLDAQTLIADLCSEFEAVHDYVFIHNKEVLHSSLDLDNMLALYTYLIKHQGSVSERQELRMKPLADGEGVGEAHIMKSESGDAFSPKVHINGQAYHLGVVCMGGLYLVLLLQCDDVMFTLSSIKEYLSGTPNGMGALLKSLSQPPVASKLRTVSINAVTKTIRSVGYNEIDEKALRELQVIRGIHHLIESSLEVITRMHVRSKQGWCSAQVSNGREMYLTLPSESLSLTDVSGAFNEFVKTFLGGIYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F4</accession>
    <name>A0A061D8F4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766211.1">
        <property type="nucleotide sequence ID" value="XM_012910757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8F4"/>
    <dbReference type="GeneID" id="24562566"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103400"/>
    <dbReference type="OMA" id="YICSVNA"/>
    <dbReference type="OrthoDB" id="447602at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="378" mass="41655" checksum="6A03913D48A51225" modified="2014-09-03" version="1">MTGAVEAPKSGPKVNLEAICKDYPNSKVLLISVQRPRPFFIRTSCELLAGGTEVLILSALGDAIPHCVQLQHALMMKNAATTIRFETALNKCTNPRSKGPVYIPGVHIYMRKHPEFKGSRISPAYVSFNAQPNAGELAHAFKADAGEHCCKVIAGSTSFAMPSKGHQHVHFTELLKSTGHSIDAYTKLFSTLYQEAMAAHAADPTVFTVTMANCAFQHPDLKFAMCRVSKNQQSFKAPGEGVVFICIFKKHPYDNVHNMGLIYVVEPQAQNYADVGDFYQALHATGENLMTAVCDHNGMAKRDPTRSRKSMICCSTYLICGEKNRHPKATKIDCARHVLNGIAEGYRHGPASTFHFAYDEDAYRQAWMETSGLKAEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I7</accession>
    <name>A0A061D8I7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0301860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768468.1">
        <property type="nucleotide sequence ID" value="XM_012913014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I7"/>
    <dbReference type="STRING" id="5866.A0A061D8I7"/>
    <dbReference type="GeneID" id="24564823"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301860"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="554" mass="62568" checksum="3ACDE57B53F9D93C" modified="2014-09-03" version="1">MTGFNVVANFNATGWGPDETDAKTVESCLGGLNKLPLEPNLKLDRQIRICDFTFLTYQKSIRDAGRFGRQQPPVVLDEEMQFQTVDGRSLVKTKTMQHYRRKVVPKQTTQAFNQKQMEEEAMIMSAKQKHPDVRKQRMMHQRTNRSNARHHTFNEWSIEPLPSWQLLTEIPFSQLSKLDLHGGQVVGTDVMWRGKLGVYDKRMDHISAKAEMLLQIPTTQCDYYWTSTNDDDCIVDYLLANGQSDSQADEGAAPVADKIVLGATDQILSVLMTAARSKYSWHLNVTKIGNQIIVDKTNGSIVDMLTVNETSPEPPMPDAEVKINRPPALGHEAVKVNQRIRQQVLVPGELTDEFEQPPFVEEGDNPSTMAYRYRTFNIPGNNHGQGWERVPIHVITRGEIHARVQGIPNAGYTYVCALNEVPHKTHKSWRTQIETQKGALLANEMRNNTAKMQRFAACAMISGCDTLKLAYISRRTPSDAEHHSILGIHTYTTENLAVQMGLNMRNAWAVVRLICAMIASKPDGQYTLVKDPLKPNIRLYAVPDEEDGDFQAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K0</accession>
    <name>A0A061D8K0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0103880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766261.1">
        <property type="nucleotide sequence ID" value="XM_012910807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8K0"/>
    <dbReference type="STRING" id="5866.A0A061D8K0"/>
    <dbReference type="GeneID" id="24562616"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103880"/>
    <dbReference type="OMA" id="NCIIVIE"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="319"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="482" mass="53545" checksum="E35BCE278D7A089C" modified="2014-09-03" version="1">MDKSEDMAAFMAPGTFRQLVEVSRSASKQVDAADASKQQKSYADSIIFSEVCHYCITGTPILGTLTLTTEAITFEPDARDANVYERGRGYYQVHVDLVSIEECGLIGVSAEDLSSYDRGSMHCNGLLQILLKNGRRDTSATAAVEDPFDPFFCEHRIVSKPHTVPPKESRSISLVSQGISKLSYVANMAGFGSTPKPPQERPPQSAVQAKVFVVFAFFKKEVAHRCTLALMDALDEAKKRAAAMPSRSRISRVPFTSNELLHMLTESIRPEEQAQQRRRRPSDSRSRKAAGKNTQQPPYVHGIAESENELRERVAQKSRILTADMVNQLVDNLPPALAIRNWEVTFKTSHDGVSFGTFYKNLQGHEHCLMVIKDDHGNVFGTFTGHIELSYRFYGTAETFVFKFDNGRIRVYRAKGNNKCYVYSNENTIVIGGGANSALSIHDAFQSGTTAACETFGNDPLAPTFVFNIEEMEVWTFGGYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L9</accession>
    <name>A0A061D8L9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766281.1">
        <property type="nucleotide sequence ID" value="XM_012910827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L9"/>
    <dbReference type="GeneID" id="24562636"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104030"/>
    <dbReference type="OMA" id="AHENPHI"/>
    <dbReference type="OrthoDB" id="365760at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="109" mass="12131" checksum="A687C7F9A47E980D" modified="2014-09-03" version="1">MRSIAARRIDRMLSAQPLPLTAVNKISLKYATDNECATYFAKELLPLMAYGNKHIEFNAAAAESGEKQYCSVLLSSGSNVTLNLKLYRYPLQIMQRIVDVAATQEESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M5</accession>
    <name>A0A061D8M5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769252.1">
        <property type="nucleotide sequence ID" value="XM_012913798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M5"/>
    <dbReference type="GeneID" id="24565607"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309690"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="301" mass="32891" checksum="BD8451A64501CF08" modified="2014-09-03" version="1">MVEGQGDNQCGCKPVSCQGNEELCSDDKCTKCEAHCPPGCKGCEVKCKGVKQPGTCKCCTPRCGCKEDCYASGKDGKCQEKNKIDCKRCIIRCKDSDKCICYFCSCGTKCNGVICSCCSWCDPSNCSGGPCNGYVIGRCGDKNPKTTECIGHVKYDIYGKDGTYGAVYKRNTENVIPCDGRPHPGKDCTDNNCNWLRGELQPDGNCVIKCTYCGKLCGQDNFTRCCTIAIPLVITVSAFLIFRFMLPEKYHAIMTKIRAAFPSSPRHPGKSPINLVGNITPEETNVDRYSAFRPRAYAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8T7</accession>
    <name>A0A061D8T7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0310290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769312.1">
        <property type="nucleotide sequence ID" value="XM_012913858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8T7"/>
    <dbReference type="GeneID" id="24565667"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310290"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600703" description="6-Cys domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="10">
        <location>
            <begin position="836"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="964" mass="108426" checksum="42DA839F40F9B4EA" modified="2014-09-03" version="1">MGPSRLKRTLTLCAMLLNWIKCVNALICDFAYPDDLLARHALVTCQMDIDYSGPVTAICPSSVDDTNYIWHPQQTVDQDVHLNAYVNENRKFKSVAISDVVRSEAHTPIIWFEPDVSQTKLHLNTSANDLIAITEHRLIFICGPQDFILTEAIQLYLHLNRHRFDGQTQMLTFPWDDSTPLTHQSAHTARGLGVLTLNRLNRHLPLQGCGSRPSPLFSLDSEVTVDPITGVRSCVADPMSKLPIGFVCEGRIEPSDCMRSLIDHNGEVVDAPEPYAYWNFYNSKPWIIAEYFNQLALPPFNGKCWCKDHETDQVKATIEIRAKSEYVCDIANMICLNRWHPVTGPWCSVVLHPGSTLTIKFPVKGVYWDSRSAHCAATSLIHNIPKFTFKTDFFPTDLLRLRQLSSQYDVDAYEEVLYHETLAGDALDLDVSQMFRGEVKLKYHAGKPLALIRGINSFHFNWSLIYKHMALFDMIRAIVNVSFAFTHQYTITGCDREQTNLFDHNFSKDYCYTSSMGNGIGGIYECAFRLKWGSLRAGIRCRQNEELLPNNCDNVAYDLYSNQIVPFPGSLRNVTPYPMQGFKVLDFEFRNENPVIHACVCVDQRGYETSRIILEYDHQKHYTYGINSQSALHTSLPFIWIVWPDTQALVEVPTAPICVKIQDIPQESIAMRVGETLNLHCGIDSAASLQYDPFVLGTDDDDMATIWLPEQTAEFHYAIEPAGDGVGLLRMRYTDSMATSSGSLRITNYTHLTAYKSLRIETIGSAILISKDSVHKDHAPLTFVCGKTLKPSGESATTGNASTSNTSVERNLQVEESPKQYAWSLVHVNIKTTDPYMQGCGVTYESDELFKPETPKIYDENGQEIGCRIDLQAGGEAAFYCPAPYVLDPPNCFNQVYVNGDVTNVNNISNSLVASHSNHFVTLRFDGSQMGPGEALRETPPLECRCVTIKGIVLSTIQIDNYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8W4</accession>
    <name>A0A061D8W4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0204720</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767500.1">
        <property type="nucleotide sequence ID" value="XM_012912046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8W4"/>
    <dbReference type="STRING" id="5866.A0A061D8W4"/>
    <dbReference type="GeneID" id="24563855"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204720"/>
    <dbReference type="OMA" id="DMVPTPY"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="82"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR95314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="443" mass="50757" checksum="B52D005557C67E16" modified="2014-09-03" version="1">MAASRRSNSRDSSNDGDLLTPDDPEVPSDVHEKPENGRNEAETTDEAPATLESANTPSSITGGNDLGPITDTLECCRNVDIYKCLNKISEGTYGSVYRALDTETGEIVALKHIKFHEAHWKEGFPVSYLREIAILLELRHPNILSVKEVVTNERKDQYYMVMEYVEHELKTLLHERKPDFTLSERKCLLNQLLMGVAYIHEHWVLHRDLKTTNILYNNRGVLKICDFGMARKFGQPIKNYTQNVVTHWYRAPELFLGQEKYTEAVDVWSVGCIFAEIISGKPLFTGVNDSDTLDKIFRCCGSPTKENWPDYTKLPLVRDGRFPLTSYKPNFHTYFKNNMGANEGCYMTELGMDLLMKMLTLDPSKRISAKDALDHPYLTTERPRTQTVELMPTIPDTNAKLRRKREPEEQDDEAGRESRFMGRVNPVKFLALMEKARSKQGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9D5</accession>
    <name>A0A061D9D5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Charged multivesicular body protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0206970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767725.1">
        <property type="nucleotide sequence ID" value="XM_012912271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9D5"/>
    <dbReference type="STRING" id="5866.A0A061D9D5"/>
    <dbReference type="GeneID" id="24564080"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206970"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="23957" checksum="64367E84BEA2C202" modified="2014-09-03" version="1">MRYPYSGSIAPGDLAYLYTSRLEGISAKISSVDEKINACNAELAGIKAGLASCKNPAAVAAAKRKALQVLQRRRVYETQKEQLCGVQLSVDQSEHVASQLQTAVDVRNALESSVKSTRKQLKLVNVAKLERLQDEMEDLADYADDINEILSRSYAVPDDVDENDLELEFSMLEEPEEPLLSGATSPVKVLQNVKGVAFPSPPTSEKTKLPDKEFEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9N8</accession>
    <name>A0A061D9N8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maf-like protein family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768878.1">
        <property type="nucleotide sequence ID" value="XM_012913424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9N8"/>
    <dbReference type="STRING" id="5866.A0A061D9N8"/>
    <dbReference type="GeneID" id="24565233"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305960"/>
    <dbReference type="OMA" id="RDQRMHK"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="278" mass="30837" checksum="E58A031CC3394831" modified="2014-09-03" version="1">MSFTSILSLGDQFSNPDRDWVVLATSATIRAHVLRQHLNIQNLLLLTSGFAEDLDKSEFEDVGDYARATADGKARAVAQRVFGASTPEEVKAVLEDLKNPFGSVPTGFDISKVRFVIGADTVCSCAGEIFEKPANIDEARKQFTAYQNAYPEMITGVSAYAREKGHDEPIFSFYESTVLRFQRMTPEDIEAYLRTNEFVGTAGSCRITGFAESLIEWMDGSYTTSVGMPAQKVSRNLCRYLTGFVIEGEDEEFFEDDDLECEVENTVDEEVKGDAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9T9</accession>
    <name>A0A061D9T9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0313680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769652.1">
        <property type="nucleotide sequence ID" value="XM_012914198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9T9"/>
    <dbReference type="STRING" id="5866.A0A061D9T9"/>
    <dbReference type="GeneID" id="24566007"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313680"/>
    <dbReference type="OMA" id="ASFHAHM"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="26889" checksum="C5D0CF3D919BC1EB" modified="2014-09-03" version="1">MAITFKLSKSASGSGGEPKEDRSAPTAPKPADVKRPPVFGTDSDSDGAASDSLGSHPLSKRAKVSQNAASGSKTDSRTASSSVASETKPVKVTYKEYDLSTENLAPELYLYDELEEESSKDAKDRTDASSLVYLGCAPSGPAEKASPAVAKDSQYMQKLLRTARDRRMERDIAFDKQQLKADLESGESVGEVFVTGAYKRQLEERRRFEEEQRRKDEADLKASGKSVASFHAHMLKSGIASRTNRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9V8</accession>
    <name>A0A061D9V8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769474.1">
        <property type="nucleotide sequence ID" value="XM_012914020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9V8"/>
    <dbReference type="GeneID" id="24565829"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311910"/>
    <dbReference type="OrthoDB" id="365422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="694" mass="77539" checksum="8085A0C985C40EA7" modified="2014-09-03" version="1">MDIVEVKPQDALQAVRRRPLERRPVHIHEGVIARLETCERKKDHIRGSGLQYVLRSLNRHCSQLSPDKLLEALRILSENQLFDRRTLYNLYDSIARNILYFTPAQHRKLLTYIGTCLSYTVHGAKLLSAEDCATVISQLDSFLPRNAKDTPSGVADAVSDTNESHGPDQTVNDDAVVAADEVVGAGFNYLSIADFDGGPVPLDELNRLNLEIVRKTAALYGANILGGARVVAASDSGAILGSALEIMLKLSSTLDVHTSTIEDCARNLADIVSHVNIESLQSLGDARDAALRDLVRHAHGIADALSIMLLDVLPKITRAVSLPKCGISDYLTSSMYLKLDLLRGSREVRSAYVGADPTLFRMLSDALHHITARCDSEDKQPLSLDVQQSIFGMKQLESQMQRLCELLNSQNLDCFNDIVRLNSKCLSLHKVLSVFDTHGQLTRHDHDGNSSDPPYTLRDFASRCVEEFGNHIEAMDPSVVSMLLCIIADGHGSPPEQLGDELRNILPECFRNLYVNSKSLSTASILDVIERCYTKMGYLHHYGARIMLNTALSRYVISHADAVLAANLHMLCLRIPYDMVACVRRKSFMRVVSYLDDVGLCEHGSRKFDREAQEVEGEEYHYNGRGTRFLPDRSAGRVRCVYSSYRRSCGKPKYQPNQGDEKSLMPRQRGTSHIYKLWKAVQPDLLRKLLPLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9W1</accession>
    <name>A0A061D9W1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PHD FINGER PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0108280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766716.1">
        <property type="nucleotide sequence ID" value="XM_012911262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9W1"/>
    <dbReference type="STRING" id="5866.A0A061D9W1"/>
    <dbReference type="GeneID" id="24563071"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108280"/>
    <dbReference type="OMA" id="PCEYEVL"/>
    <dbReference type="OrthoDB" id="366266at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="110"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="711"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="855"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1249" mass="140438" checksum="8A2F969D0557E894" modified="2014-09-03" version="1">MNVRETAQSTATDLGCSFEGFLLSHYEEIYHERRLPCVVCKKMAPSSYVYDGQSIDCHGKCLAFVLFYYFMHFYDVAAPAQSREAGEMPNLTKLYKMPFQLLNATEYKRHCVFCGARSAFFKCSSENCLNHYHLSCNTNATIVVHHGKTDSKKPCYRFLFCQVHMNSYEVDLVNCRFNSKISLLEEYELLKKGTVPIKDPTPAEPPTPIPSPVSTSVTTRGATKVQSHLKLERVEKKQAVVKGAVVTRRMDESKMPRTSSHEARTDTTNINVTQSQEKFGHSKDYIACLLNEYGVLKRHGYQKNTKKFDWWPYEVLFSKIGPDLFSNIAPLNSGLVELYKDLRSVLVFNKCVESVMDLRKVALECEPCVMNITGSIASQLKLDANPASLQGSPTSRSLPAPTHVPYDVNVESMQQVLYGQNAHLAPGMNLNISQNNEESPLQLGFCQLVGHKTHRPTFVLAKFGSQSVWLSAAHVKSRRDGTTKLVLLDYIHTGSLEYEYLRRVLKSIYCPQSHLMAIPVLMPPEVDEAGETYPEVETINLSGFCWDLKPSVTAYLKNRLVTSDAPVEEGGTAHDEALMEIIDTKEIEDNALFSDPVSSKQRCFVTNQANALVGVLKAVNKAIDEHKSKLHQSLMVEHAYSKRLHEDKSLVEQYTKVATRMNRWSHFRRSIMQAVETFNNFLLHESRADDQQNKNEKVKAETVKDTTDKEFCSVCLMAEPAQKQMMHQCSRCFIRVHFKCYVSYKPTTVEPVHGTVKSEETVHDWFCDPCEYEVLMNANSRAATCNNAVCCVCYSSGGALKRVSEHAAKRNAPSMPVKWVHLHCAALLMPKVTCHDWVDLNKWDLRNSNASTTEKCSICTVSGGIMLHCARPGCNNKFHTTCAWVGGGYVVESPLHNATDLPGMVRNTLTFNELFPALSLRMLCAEHTAERFGDRAVTALMRRRCYAYTHYQYSPQNTNNDMKNAILPLKPCPSHIIVTRNGAMHSTPMESIRPKEEVLAPEPTTFEMVTKQRKLPMAHSVHDVMPTTASHGVVMNSHHPGMMMVSTTPSVMMNYPHGMMVNTAPSMIVNGGQHMLVNGGQHMVVNTGHHMMMGGGHPMMMNPHHPSMMNTQHTMMPTGMRKPTMAPLVYGTHNAYMNEQPRYGVSAIASHLSGGGYKQPMSHTNVNHMEVPMQHVMMPYVAPVTAVPINGGMLPVAQHPQYHHNGYQQPVQMVPKYWNPRLNQMQYKEQQPPPDNPYVGVGGMGYMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Y1</accession>
    <name>A0A061D9Y1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769494.1">
        <property type="nucleotide sequence ID" value="XM_012914040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Y1"/>
    <dbReference type="GeneID" id="24565849"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312110"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="213" mass="23487" checksum="7075F16B99116519" modified="2014-09-03" version="1">MTSTRLTSNSDANTPNNSLISASIKCYVKWMIPHPVERPDAEVDHDADDDNDEGDGDDNVRENRGGSLSTYLLLCTGEGGGTGGTGGEGGRFLMQQSHIHGRNFGIHFGDIGRTYDIGKNIEYIFHNTSSSKDTCLLCIVCHTYNSPSSRSPPSPLNLQRYQSLKQRTHQLLMNMLLSKAYPVQSTYSTMNTHLSKALMVSHRRYVSSKVTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA98</accession>
    <name>A0A061DA98_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766851.1">
        <property type="nucleotide sequence ID" value="XM_012911397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA98"/>
    <dbReference type="GeneID" id="24563206"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109630"/>
    <dbReference type="OMA" id="TTIHCAP"/>
    <dbReference type="OrthoDB" id="366245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="293" mass="32621" checksum="FEAEF73F68A72636" modified="2014-09-03" version="1">MQCTTIHCAPKGWRDLEAAIENVRRHKLGPHSASSGGSRWTPVALVLLIVCAGVATVVYVETVRSSLLDATGNAAGVILHNRAFHDQSMVFLRRLAEDFLNSAETEELLKRKVEQLLLSSGEVLRDTVIRLLHHDEVTKTAYAFSRQITEDLCKDEEVIEYVGQLLLDAINTKTAVDGAAKWFVDIAARDDTVEAIERLLCERVLSNANVHAEALDLNARITNVQCKSVTSQFLSAESTKRESVAFIKSVQDRPSIHAHLSQALIEVLKQSFYPRWPIFTTWEFNGATGLWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD4</accession>
    <name>A0A061DAD4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0401580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769852.1">
        <property type="nucleotide sequence ID" value="XM_012914398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD4"/>
    <dbReference type="STRING" id="5866.A0A061DAD4"/>
    <dbReference type="GeneID" id="24566207"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401580"/>
    <dbReference type="OMA" id="HCGVCKE"/>
    <dbReference type="OrthoDB" id="421575at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="285" mass="31393" checksum="A9F0D610DD35E416" modified="2014-09-03" version="1">MASIEESVYFCHICSSLRSDSQVTPTSTGDICCLVCNNEGFVEKGVFQNALGPGRQGSSVTIRSNVDGGSNSVASSNLDDGRAAAAPEGEGSAGRPEQSIPDIPIELFRSILQNPFDIHAMNQILYYVMENNSNRQGPPPAAKRILETLDTDTLDEEQAKKLETCAICTEDFVAGDKIHWLSKDRTLCGHGFHVDCIVPWLKQHNSCPVCRYELPTDDANYNRQREDLRSRLLEEVQRHVDSTSQPNSGRQSSADESAPDDSAPQGRRSRYAGGRLIHDHNCRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG9</accession>
    <name>A0A061DAG9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766906.1">
        <property type="nucleotide sequence ID" value="XM_012911452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG9"/>
    <dbReference type="GeneID" id="24563261"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110180"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="283" mass="31755" checksum="6DD70F03F834A1E5" modified="2014-09-03" version="1">MEGRMAETKGTNPCGCDGNRCTKGGDRPCYDYKWRVARPDVRAVKQNARRMRNVNVVLLSVVVLLIVMAKAITTVKEKRAIIADAVEKNAKVGNHVYVILAAAERDVMAWCDPRNCSGEKCDGYVIGRCKDKHPDTTECKGHVKYDKEGAVFDRNAKSKIKCDETHVDCNDGICNKWARGKIDKDGNCIIECTYCGTLCGQDKFRRCCYIAIPVIIIVLLFLIFRFMLPEKFQSTMTKIRAAFPTSPRHPSRSLSDLVSDSVPDETNIDRYPAFRPRAYAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAL2</accession>
    <name>A0A061DAL2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bromodomain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0210880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768125.1">
        <property type="nucleotide sequence ID" value="XM_012912671.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAL2"/>
    <dbReference type="GeneID" id="24564480"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210880"/>
    <dbReference type="OMA" id="IKTLPRW"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="1778"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="787"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1494"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1283"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1911" mass="211582" checksum="10C93CDCDB36B93F" modified="2014-09-03" version="1">MEGNGKITPTRLPPADSERDAGQNAPFNQPGGAAAAPMPMGDGVSSSESNGEAMRLPDTEQSAGPGPENKPFPMCLPPMAGDAGPKSDAPAADTPKAPPSAKAATGGPPGDSAMPEPLLPDQMPPGMMGMPGMPGFFPFPPVPMPGMPGFEGQGDKNSTIGGPKMPPFGGWMMDGMMSMGMMQNTTNSIDGSLMPAMPYAPGTSGMKASDGSAMPMMFFPPMMMEGLPDFAKDPSGKRLPPMNMMMPMMPMMDEKTALQSLSKLAPPQKTSLQKKASELDSMKSILTSVQIRETCQLKAWRRKLHKGRAQMKLDVEAAMTPSRRGSELSQEVKPVVEVAPHDAEPAEIQVKAVPTRQYGSMDMCWQHNRYRSADALTEEDMRSMRLFETAAQDGELLTIRDALKRLDGMESNCYPYMFMDELRLPVRKGRASFRVWDDDDNDLSHGDDPSGVTLPGVRSVTPHADWIPAAETPKKSANRVSSPEQQERLQQQVDESAATPQAVDPAAADVAGMGATGDGAVSEPNAGNNDLELDLSDFERGSNASFDLDFEDAEVSAPVETPVPRTAEPGVGQSHADVRLGSFDELDNELLDGMSEASKSSLGALGDMDLDDEFEFDAADDGVAPPPAPPTYPLKASGVPDTSAAVDVSYTDDSDLFAEVPGTLSHYRAKICKLMNPGDIIHEWRGFKSRLNGPLLLADLVEFEHLWKVFQDRRVEDLCQVLGRSVNTNAAEQYPEQKGELLYRVGQAHMKLLLSYDSPEVQTLVHSSIYNLNAPNVIYTAVPDEEDITPNDAESVHQDAPEEVATKEEEEETPAAADEETSKDDAALLSKENELRRTWRRRLQTLNKETRLALVNMGKSLRDIENVSSNVEQSRAYDAVVEFCEVAEQFRHRDYLNMLNQSFDDYYEKANPHESGKDSAGSNLRELLHTRIAKNLTGILPLGGKVAKYHNVRFHKPDFRAGLFSEHTRVQRGNYSIEWSSWPVRPLLRSNLAASYTEESGGSDDVRSHPSNYFLHSNDLRLNDDCKIALLEYVEQTPLLLPNCGMASRVDNYVNYKEDDDHKDVAFLGPLGTLCQGSDGIEMFGVKHMVAPGDGQAMLESTLYKAPIFVHPRPASEWHNKLNITTTDFLLTRSRSNSEVVIHLRPLTWQSGVAVYTVGQCEPKVDMHPPSSKGFMEATNDLLKAWVLKSVMAGAILDVKHLRKEARRKFGSLLTEKEIAHILKQVESTPIFSLRAQALERMIHSTIKPETVCALESVRAGRTRLATVGILHLKNPDNIAAVLAKVQDEERQYQQRMQSMDRRLRDLKNSYAKRLEAHGITGEKQENELGQFEFGLHVSLYGHLEERTLAPKIRFIKDMLDLTPWNISRDVKQVLNNRGASQFSLYGIGDPSGGRGEGINLLKRQAHVNVDPTYAGEDLRKLSMLELAKRLRCYGVAEAVIKTLPRWDQVALVRQYRDGFGGQGSAEGDHRWRIPPEEYQKKLNEILVRQRTALASDEPVVDDGETPRDNEPEPATDGIADALMEAFDEVSDKDDDLERRELDILRQLREAQSAGPLSEEERMAEVNKLKAVPGIMWLRQSRRTHTEPFGNERAVFVYGEENVRKLLRWRMRCGSTRKTCSTPDAAAAAAASKRICRVCGNVGHISSNPKCPMFKGERGRSGEYMGGRVGGSVGARKQSRYSDSSDAEITASVAALECDTTEWLKRNQELRQKRRLTYQASVDDSDDGMDSVDEGSLVNARRKQMRPNIEVGSVPVTALSSQMEQVMKLVSKAIRIVEKEPRFKPFTSRIPESVAPNYYKIIKHPMWLTLLKSKCKTRCYADLVQVLDDLALIELNCKQFNSETSPNAWLRKMSETLVDELLLRIQQLTSHVVSPSVIEEWAREHRANRIVAAPAPQADAPPTATPQVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAN5</accession>
    <name>A0A061DAN5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor Tu-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0110720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766961.1">
        <property type="nucleotide sequence ID" value="XM_012911507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAN5"/>
    <dbReference type="STRING" id="5866.A0A061DAN5"/>
    <dbReference type="GeneID" id="24563316"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110720"/>
    <dbReference type="OMA" id="IYICMGG"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="941"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1224" mass="135875" checksum="C1344996B2139B4D" modified="2014-09-03" version="1">MSERADMLSFTEHIRNVCFLAHVDHGKTTLSDSLISSVGIISERLSGKLRYLDNRDDEQRRMITIKSSSISLIYSPNNPTVRTGSAKALNDSPCIINLVDCPGHVDFSVEVSTAARLCDGALLIVDAVEGICPQTKAVLRQAWRESVRTALVLNKIDKLILDLNMTPVEAYQRLRDLVDQVNALMFQMYNEYLNVDADEEGIKVDVSAKKWFFCPSEGNVVFCSALHRWCINLPEFAEHIVHKLNVPPAKSGGILKALWSDLYYCPRSKTLKPCHGREKPFFVQFVLEQVWKVYDAIMTNWSPADIEKCVRYSGATLSARQSRLLESSATPAAEEREELLTTVMGSWISIPSGIVRMIVDCLHNPVQAAKKRLKRICPAVLDYPAYEEVISCKPTAPTVVHVAKFLGCDLNIMRLTGDVLHGDELAEEFVAFARIFSGCLKVGSELYICAARRPAAGCGFADDIHSDVRQRTVCVKRIMICMGADLLDVDTGWPGNIVALHLSQPGSSPGDAASPHASDAGRRDNMDHVKEVMAWILSLGDPHRQKVKNLGDEFDNRSRFTRQGNLCSVDRHLTLSSDPSFPGFPPLNLEFNNPIIRVSVEPQNVKHTQEFLMGLAYLYISDPAIELDVLKTGEYVLACCGEIHLERCVNDLANLYAKVPITVSKPRVSVREGVVNLPPTDTSAVAYSKALSKMVNFPPWQNNSNAAEEQPAEPDPTVDHKLVTPIKGLPGTYITAAALKLGTEYAVTPSGDTVLLVRTVQMPQQVLDYVENNNNDIKRAIYGGEPPPQFATGALEQRMSCYLEKLENDIVATWRSSTVQRGATLDVGHLWAISTNRGSRTMLFYNDNNGLKVLAAPATAGDEAAAPSSTDRQKLVRPPPMEWRFRDTYQPEKISTIEWSKAISAVMSGFEVASQFGPCTEEPLRGVAFVIEGMYTISTPCPDASPERSLYKARKPTSPAQREDASEETTRNDVLSKLLHKREFQGDAKDTQSEPASDAEEDEGEGYMRIGSHVKLVTNEHTTFESGADDIQDTLSQFSDVLTFQSSRRSGSGVSTAGNIISTMRNICRKAIMQRGRPRIYEVMLRLELQCDQGVLGKMYSVLQKRRTQIVAENVRNCTNTFVIEGLIPASESFGLAQDLRSKASGGVVFHLQFSHWEMNPDDPFPEVSMTDEEFEDAGFNMARMLQSNVPRKIINYIRKMKGLITEEKVVASAEKQRTLSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP3</accession>
    <name>A0A061DAP3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0309600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769243.1">
        <property type="nucleotide sequence ID" value="XM_012913789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP3"/>
    <dbReference type="STRING" id="5866.A0A061DAP3"/>
    <dbReference type="GeneID" id="24565598"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309600"/>
    <dbReference type="OMA" id="RRCWVYL"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11523">
        <property type="entry name" value="DUF3223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="55"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="417" mass="46777" checksum="901C35D91E0935EA" modified="2014-09-03" version="1">MTDTEVSKRTLEADGDEGGVSKKRLVTDSSSVEVVETLLGKSRVTDEEFKVVLSHATPEQRLRFIQRQIGHYLSNENLSRDNFYHQKFTEDSSKAGVENVLELKYILSAKRMLDIKATSEDVKSALDANPLPGISLEEISGTLYVRKNDGLPRFEGRKLFEKKKKFGETHDTYHAAGPILFISNVPESVREWTPVKEALQKDKQVRVRFISPVSDNGTCFAWVNKSPEVMTAVKELAPELEGAVLHVSLVDSEERYKEFISTLKPSILSSRNKELQRIHSEIMSSPLEINGLVIRNFGSIRPLLNGVLESSDHGTAIAVDSQAGVLLKFVLDFHPRAYEKLCKSHRSLVGFEIAVGAFKEGSKKKCFLVITKDNNSGKEYKEDFSISKCLECLRVMAHTIPKTEKRDFIKSLSVTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB19</accession>
    <name>A0A061DB19_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC1family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0403540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770052.1">
        <property type="nucleotide sequence ID" value="XM_012914598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB19"/>
    <dbReference type="STRING" id="5866.A0A061DB19"/>
    <dbReference type="GeneID" id="24566407"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403540"/>
    <dbReference type="OMA" id="PEYYVPR"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="5">
        <location>
            <begin position="107"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="445" mass="50271" checksum="D94BFF2716A8441D" modified="2014-09-03" version="1">MNQNAVPADRFSRVANIAGLMINVASTTAKQAVQRYMQVGAERRWTLTTVQGERGNVIQQAMASDENVKLLVDCLCKMRGTALKFGQLLSLQYGILPESIRRALVDVRHRADVMPEEQVIQILRNELGDGWRDKFEVFDLQPMASASLGQVHSAVTKDGRRVCVKVQFPGVADSIDSDVANLIFICTKTNLIPKNFFIKQFARELKVELTTECDYGNEASFYKIFKQLQLEGFSVPDVIDEVSTRRVITTEFVPGVPVEDCKHLPQHVRDSIGDRLLRISLSELFIFGLMNTDPNPSNYLYDEKTDLIGLIDFGSCRSFNPEFVREYSKLVLASVDEDTEKIVSLSRSLGFLGDEDTDEMVRHHVESVLITGEPFRHDGRFDFRKHDIIQQCREKASIILKIRKQPPPPEVYSLHRKLAGCYVICQLLGAHVDAKSIFETISQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB32</accession>
    <name>A0A061DB32_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0403690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770067.1">
        <property type="nucleotide sequence ID" value="XM_012914613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB32"/>
    <dbReference type="GeneID" id="24566422"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403690"/>
    <dbReference type="OMA" id="IVEMDYG"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="477" mass="51280" checksum="79DD902970D307FD" modified="2014-09-03" version="1">MSAEKTAASKPTVEYEGFARFLYNLVSFMQGYDQQILSMCMRAFEATLGFSQSQLSTMATVSKMSRLGCCLIWGILADTSQPHHLLAAGLLVLGMASILVSLVSHYKAILLLRFLHGFGFASIYPVHQKIVATMKNSGNSSLIFGILQGLSSLGRVFCAMVTTLVAQKVLLGYIGWRTSYVVLGYVWILMAIAILFGMQGRPNKDADGGSSSTSSTISPTPPSDSPKSPTSSSELIARVFSEVLTKPTPLILIVTVFISESLMCAFSYMSIYLQYTGVSKVMSGFAVSVTLIGAAVGAGCGGLVVKTIGESYEDYGILSCGTVVMVVRYVACLLFFLGPKPNGRLLWYHYAELVALGTTLLTIGAVDRTLVKNSIEPDLQATASATIRTIAGIGSSVILYQVSAYLSEKVFGYVPSKASFETMDAVIKETNANALRKSMMYIIATGATINLVCYAALFFTYPSEKVKPKEAENKQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBE8</accession>
    <name>A0A061DBE8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BBBOND_0405110</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770212.1">
        <property type="nucleotide sequence ID" value="XM_012914758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBE8"/>
    <dbReference type="STRING" id="5866.A0A061DBE8"/>
    <dbReference type="GeneID" id="24566567"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405110"/>
    <dbReference type="OMA" id="QALRCGR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="928"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1006"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1047"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1077"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1115"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="131"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="893"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="749"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="846"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="866"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="870"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="870"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDR98026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1164" mass="131147" checksum="C61E219EB0894E06" modified="2014-09-03" version="1">MRYVTVNDRQSTHFCSNNVKTTKYTLYNFPIKNLLEQLHEPSNLYFVFIAILQLIPRISSTHGIPVMLLPLSIVMLGNAIKDAYEDYRRYLADNEVNNSIAQVAVHPQLTKMEKAIRTIPTNEAPRRSFITKAVADDKIIYKRWHEVEVGEVIVVQNGDTIPADIVLIGSSEINGVAFVETGCLDGESTLKKKEAVLRAADHLTRDLDTALKRFKDIKGSINCEPPNQHLITFDGSLTYQISAGVDAPLEDGSCGSDGAPAPSARNRAETAGSEATETSITLLQLLLRGCKLRNTAWAMGIVIYTGHETKIYKNIPKTPHKVSNLNRIMVKLTFIVWMFQIALCSVAALWTVYRHSHGLDRALPYLQGEDEDYGLFRVFVISFFSWIAISATFVPISTIVSMNLARIAQAFFIHYDTDMYYDEINMHAAARTTSLNEDLGQVHYLFSDKTGTLTCNKMVFRKFSVAGRSYGKGYTDIRRFVLSRQGAILEPEPENPLYDKESHVNLVDDDLFKHLKNPSDPRHTHLVELFMHMICNNGVLTDATASGEVTYNSQSPDELCFVHAARFAEFKLVDKTSNSITMTVFGRKMKVRTLAMIEFDYFRRCSSAIIAFPKDPTTNLEDKDLNKFRIVLFCKGGDNVIMGKLKCKSEVDNVTASYCDQFSRDGLRTLVFAKRELTTAEFMEWNEKYIEAQADILNREKSVSMCASLIEQDLVLQGVTGIEDKLQDGVGETIELLGAAGIKVWMLTGDNLETAINIGIATNLLRVFSQRIDLHSAACATDELHAKVREWLARVKEDPGSVSHRCVVIDGIATAELTKDEIVEEFVELCTYCHSAICCRMTPAHKGLFVGLFKRKLGTVMMAIGDGGNDCNMIQTADVGIGLKGKEGMQAFNVSDYGIGQFRFLTPLILNHGRNCYRRLAKSVAYMFYKNITLIMPIFFYGYTSLFSAQRILLEVLVALYNVCFTGINVILVGSIDRDIDKTLSYRYPHLYQLGQKNYYLNAKVFLGWLFNSFFHALIIFLMMNFGLNDRYTIPSSDGLPLTSPQLGIGMLLIVMIVVSCKLIMETWYYTRLTTATYLFSFFNFFLSIYVISLSSKLGSGLLGGAMNLLSNGRFWIVLVASTAASLYRDYLMKVVHYSFLPHYYQYVQRKEYLANKLDSFRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBQ5</accession>
    <name>A0A061DBQ5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769573.1">
        <property type="nucleotide sequence ID" value="XM_012914119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBQ5"/>
    <dbReference type="STRING" id="5866.A0A061DBQ5"/>
    <dbReference type="GeneID" id="24565928"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312900"/>
    <dbReference type="OMA" id="GFNWFRR"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56487" checksum="E10D14C0C19147C8" modified="2014-09-03" version="1">MADNLKVGPDPSKEFRYLNAVDLKFSHAEDTRLRRRTPTSDGATVVGFSEQAPWRNGSSELRRGAESKRDAESPAEVTTKVDASMRSLSIDSDKSSCALYNYFSRPNGEGCTSLSSWNSNSTESLNFERYRDMMDDSATLRSPSASLEKELIHMVESAWKSAAPKRETAPVYQNKGKNVFLKILATQLVSGTIIGRGGKGFNWFRRKSKIDDILLSMPWELYPKTDLRTMFLEGTTAAVVKATCIIADLMLSKYAAQHSATVTQSDRMLVLVVLPLFAKTAMERIRDTSDADIISITLFQSSTEHNEIVAVIKGVKSKVKALVGAIANSIAETIDLQDYCHVSYPGPDGFNPKMLPKNRAVQRNAMSGNEEAAEAIESAPKKIDDNSETSMETPDPSHQLRQGTDSETQTETCAVDLSETVHTMADMGYEIPHENEIQLNMATAAVVAESNPTINSYPINLNILVPAAKAADAMSITSASKCYVTTAPAEDPNTLVFSLSGSFEETVAVVSLIMSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBV1</accession>
    <name>A0A061DBV1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">-Transitional endoplasmic reticulum ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0405370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770239.1">
        <property type="nucleotide sequence ID" value="XM_012914785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBV1"/>
    <dbReference type="STRING" id="5866.A0A061DBV1"/>
    <dbReference type="GeneID" id="24566594"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405370"/>
    <dbReference type="OMA" id="IETVQYP"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595993" evidence="5">
        <location>
            <begin position="24"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="135"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="395"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="670"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR98053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="923" mass="101820" checksum="18852ADEEAB34EE3" modified="2014-09-03" version="1">MPRYRIGLLGVLLVASLLELPRAASLDGGIYQQNRGHRLVAAPPCSARSLRRSQKYPALIPFGWGGRGNAGGSSSPFDDDRNWKWADKSDAASRGDANGLPANKPVSADAETEENAKDGRAGSLYQKVIDGVATNLFVLRDTFEGNNNVEIRMGQEPANKLGVAEGNLVRVRGKKRCDTVCIVKIDPSITDNRVIIHADTRRNLRLRHGDVLSVDLLVDVPPAKVVKLLPFADTVAPILAEIPQEARASFPKMLMKVAVDFFSREIAMGRRRPVRLGDHLTLNVKFQDDSKTALKLLRDDHRESSCFTIEFKVMGVKSYNRDFRNISDAETGVISGESILDCTGAPLSREKHDSAYGELGYEEIGGMDKQLSKIRELIELPLLHPEVYKAVGVSPPKGVILHGPPGTGKTLIARAIASETGAHCVIINGPEIMSKHVGESEAKLRRAFEKASKNAPAIIFIDEIDSIATKREKSPSELERRIVSQLLTLMDGIEPSKNVVVLAATNRINSIDMALRRFGRFDREIEIAACDEDERYEILKIKTRTMRLSPDVSLRKIAKECHGYVGADIAQLCFEAAMCCIRENLASLDMLQFEDKVSPEVLNKLVIQNRHFAEALAICNPSTLRERRVQIPETTWDDVGGLEDVKKELIETVQYPVEHPEKFRKFGQASSKGVLFYGPPGCGKTLLAKAIAHECNANFISIKGPELLTMWFGESEANVRELFDKARAAAPCILFFDEIDSIAKTRGGAGGGSSSGSEAADRVINQILTEIDGVNVKKPIFIIAATNRPDILDPAICRPGRLDQLIYISLPDLKSRESIFKAALKNSPLAPDVNIRKMAEALDGYSGADIAEICHRAAREAIRESIEHEMKRGRPLKEGEEDPVPYITNEHFKVAMANARKSVQKEDVQRYEQFKRKLASSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY2</accession>
    <name>A0A061DBY2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769678.1">
        <property type="nucleotide sequence ID" value="XM_012914224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBY2"/>
    <dbReference type="GeneID" id="24566033"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313940"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="81" mass="8531" checksum="23FFF69DE31B947B" modified="2014-09-03" version="1">MALVSILVTTLVSTLVTTLVSTLVSTLVTTLVVALVSILVTTLVSTLVNTLVSTLVSTLVNTLVSILVTTLVNYYTITYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC06</accession>
    <name>A0A061DC06_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0406020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770304.1">
        <property type="nucleotide sequence ID" value="XM_012914850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC06"/>
    <dbReference type="STRING" id="5866.A0A061DC06"/>
    <dbReference type="GeneID" id="24566659"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0406020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0406020"/>
    <dbReference type="OMA" id="ICGFVEP"/>
    <dbReference type="OrthoDB" id="1924421at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="108"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="267" mass="29963" checksum="AEC6410C2E28855B" modified="2014-09-03" version="1">MRGEVVCCVVKDVLHGSRDDAYQRDNGCTRPFHLAQLLASVVGIAVFCGFWYGIRPSFVFPYYYYINTAVCVLCVVVLGLFAGVTLSDPVDPRARKRGGAENVKKCDSDTCCDICGVVDLSAKHCNICNKCVLRFDHHCIWVNNCVGSPNYLPFFALVACCTLLFTLLVALGVAVFIMDALSLAPRDAWQATYGSFNSTAFYTSTCIVTSFCAVMAVLFWQLFLLHCYLMYKNITTYEYFTMQFSENVDDSIPAWRRCIEKVVVDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC24</accession>
    <name>A0A061DC24_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0303730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768655.1">
        <property type="nucleotide sequence ID" value="XM_012913201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC24"/>
    <dbReference type="GeneID" id="24565010"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303730"/>
    <dbReference type="OMA" id="QFIGYII"/>
    <dbReference type="OrthoDB" id="391274at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="780" mass="88339" checksum="DC51C018FD631072" modified="2014-09-03" version="1">MTAANRQQLLRWRTVSYILSLLILCFQQVGLMNYMYRSQSWALYLAVFDVICVCNWIFYTSPKMVGIRGANCWIIYSRVMTVKVIVFYYIVLPEFLPREGLLFGSACGAATEILILLLLTPTLYVLTSFRAGVHLYGDMSCISSERLIHTDLIIHVTFDLLDVIDMCHVYLTIPSVFEYRNYITDALCGVLIATGIFLHSYSFPRMSETSRAKGTIGFKGGALYSASDVYYCRKYAAIVGIFFVDVPFAIFRSVLWMLLVNHTMFGPFLLKNICFIIIQAARIRHCTIGIRTLDYSKTLTEYKEEERRPILVTDIVLDDDRPSGVGELHEGREGSRSEQRKSFVRFNTKPEKVDEKDPKDQPATGQNTTDSATDDEGTFTGITIPEGFSVKAVNFRALFKKIVMAISVGSKCEMAHLLDSTLQLSLWQNAIIAIPHIVLWAVEVTIVIAFYRLDLQSTAQYVDLFHFRGLLSVSFYRLPLCLQFTPCLIVAASLVSLVCWIMVGPLIGALFVAFQVFVSLVSFSFVLLSLSEFIPALRILAFISEHTMGTPRDYLFFMFGVRPFLNLLSGLYPFLCLTLGKHYIYYINPSLVSTEGADLLGESVKLISGTFAVNKEGLVQDESFPISLASLLVLTNAVIMCAPPSSHSLLIGPNLIKAIRLDRALANSHKNAFMRTCMIRLYCILMVVGNNGREYSCAIVFYIVHMLMIPLYGLLSKGVRRSNIEAVHQQAMCADILRETRIHRTRYNRLLTYERAHVNTTPLGENHWIFKKYQRNMMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC66</accession>
    <name>A0A061DC66_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768725.1">
        <property type="nucleotide sequence ID" value="XM_012913271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC66"/>
    <dbReference type="GeneID" id="24565080"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304420"/>
    <dbReference type="OMA" id="WRNEFDF"/>
    <dbReference type="OrthoDB" id="365390at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1155"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1234" mass="138186" checksum="B0CA2225F8FC711E" modified="2014-09-03" version="1">MWAHNRVNLRKSVRDALRYRPIVDGSQLMNELLSLEKVERHWEVGFRRRFLMSKEADWRAIAQSYMVGATQWDIGALLSGALLMASLYGMLSASPVAMVVAFFAMCNMLQLRLHRDRLTLHFCLTACLGYIVLMVELLVVDPKHAVNYGGITTILGCIFLHLIVLILLARYTIGRMFERFADSCMQFRVPSLLEFQSLVTGVVAGLGAMFVVCRLYCLAFTAFVTVCFVLFSRLPSPAARRPDNVDVTGRLNVPSRQSASRSFLEACLPVVRCLISVMFIAAALCVCFASAIDDHVLSLTSQGSFRKWATEHGQADEFVPPFRSLAYMLAIMCGIILAVQIVKLVQLLLNSPRLRRALEHSTVFMGKGCLGRHGDLVYAYHNYSLDRMGKVVTVHTMGKQPLMVCDRSTLTCYDIYLAMQRRALHALSLQSYFCYVPIAYLYSTERDCNVQLRTRVKLEQMATELEHLIDRERRRRRAARRERQRRLELEKAMRNRPEFISASIPTDVGVHVVPVLHDSYQEAREEEMSRHRSMSIPVNLSLCNVSDLAPVSSLRNSMYQRRCVTTAVGDDFYLRRRTIIDRVRCSWLEHPSESFPSFEPLVPTSPRVYRDPNRGDFNFNTIDSALSSVFRGLELMKTTETMVERTPQRLRGPPYNKYKLDPTDIYPLNFDSGHRREVKRAGGDMLSCSPSVKAELPDDVVVTIDMGDATPMQSRLETEELDPQSAHVSRGVTPQSAIFSDVHADPSPGQFMDAFEVHEPVQFIDIGSAKSSIGPIDLSAEQIRSGCGAGHTDSLGKWHWLDNAVNTALTGNGVAMSSIRSDPTIHTDREEFERRRPLEEILEGEYYINDKGELVVKNDSRYVPVRYHGERSVKRLTEFYNSGRQRAIEHGVSGTSSDKEGHSHGVQSLNLTSSPLHMHALSALSDDILPMEALSRRVSHHLIITDSVKCDLEAGAMNAESESELSETVSFTEFETDDRPEFVVTREYELYSPFNLTRISAGPGQSLQRSRISDRSQKQASDSSYAPLSGSGTDDAEGSRAGGESGLAEGTDGEGATYRDRSLDTSADSLETFGDISPRELRKIAAARHLPLALDSRQEKVFSICPQPRRHGAAVAASRSKQEEYVDSVATTPVELRRHKINGSSGCDYRNRYADSADGSVTSPSSSLATPSPTTGSSRPVIPQRRWRNEFDFSPIAVHSTEDVLRELMQDIDMVDSAVEDHASDVSHDFIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC7</accession>
    <name>A0A061DCC7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate-dependent dioxygenase alkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0206330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767661.1">
        <property type="nucleotide sequence ID" value="XM_012912207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC7"/>
    <dbReference type="STRING" id="5866.A0A061DCC7"/>
    <dbReference type="GeneID" id="24564016"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206330"/>
    <dbReference type="OMA" id="RWSTIGH"/>
    <dbReference type="OrthoDB" id="364533at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035515">
        <property type="term" value="F:oxidative RNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035513">
        <property type="term" value="P:oxidative RNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="6">
        <location>
            <begin position="107"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="365" mass="40490" checksum="C0D13863D3B318FC" modified="2014-09-03" version="1">MYEENAVRSHSNAVFNEIRNTPLESLNTQTFRSSIAAAIRLSSEGAADDDASGNQRLQEALRIAGIYKVHFLPPCSDLHHAGQATVYTFDGFPGIATRSTTRCITGLYLVRNYLTEAQCERLMCRTLTEYINVSCDCHSITHAQPPNNSNIYQNDRALCTPIWPSANFKKLRWATIGHMYDWGTRSYRGYSAFPEPLVKITQSLLSHFNREYVPDAAIINCYTKGYFLRLHKDDAEETDDTVVNISLGAPAIFTIGGRDYRNSTIPVAMVVDSGSVVLMAEDSRFCLHGVVKLLGYNKPGRHDCDAGGTSDVGDSAYAAPRLSMVIPRCGDDATASLECDPESLDSVKRLFADHRVSISIRRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ8</accession>
    <name>A0A061DCJ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING FINGER, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0306580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768940.1">
        <property type="nucleotide sequence ID" value="XM_012913486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ8"/>
    <dbReference type="STRING" id="5866.A0A061DCJ8"/>
    <dbReference type="GeneID" id="24565295"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306580"/>
    <dbReference type="OMA" id="NACPLDN"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000273">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="11253" checksum="D7FE3250922E2A02" modified="2014-09-03" version="1">MATEAAKPRFTIKKWSGVALWSWNIAVDNCAICRNHIMDLCIECQAAGSEDATNNDDRCTVAWGACSHAFHLHCISKWLKTRHVCPLDNTQWDFATKEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCK6</accession>
    <name>A0A061DCK6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768950.1">
        <property type="nucleotide sequence ID" value="XM_012913496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCK6"/>
    <dbReference type="GeneID" id="24565305"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306680"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="321" mass="35744" checksum="6BF5BFAC53135B0B" modified="2014-09-03" version="1">MVYTSLTEAPHNLKEAIDWLLAVKGDDATTNLTGLGAAVHKFLANKPIGNAVVPALEKVKLITKEFVWKQRTRGLWYVDRMLKRLEEKLWKGREELVDALEYVRESDYQNIIWTEGTTAEAVIEKLGEVVDGTEMFLDDVKIPEQYESAYSSEATWDASCKEDPRACAMVFVGIAPMLYTGLRSLKDSAVAATWPSFLMNSPGLGDMLDSVGYKDQAIRTSLSGPEVTSALRAVDGQFLNIIYDLAGFWAFYGLKNPAMQPDKNRKYPIPGVDYRINMKPIKPPKKYVLRKAPSTYTATGSNNTYNPGVPTVLDMGDTIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCU2</accession>
    <name>A0A061DCU2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767951.1">
        <property type="nucleotide sequence ID" value="XM_012912497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCU2"/>
    <dbReference type="STRING" id="5866.A0A061DCU2"/>
    <dbReference type="GeneID" id="24564306"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209190"/>
    <dbReference type="OMA" id="DTMIQDS"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="109"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="384" mass="44585" checksum="01B1CC1B147B67C2" modified="2014-09-03" version="1">MEDRPLVSTSRSLMERISFGLFGLSKRVIQRNLSRVQPEEPTPSKSTDQAYDSYGFSVSDNAFADGISAYEDSFNEKRERRLKRWDEMDLKGEWDTKDPLPLKVLIRKGIPDHYRAKMWFQLSGAEELGAQIRGLYPRLVSQPLDPNIVKQIEMDVYRTFPTNLNYQRHSEGTLRLRNVLTAFANFVPSAGYCQSFNFLAAILLMFMEEENAFLTLVQMIDSRIDNKGLSVLGYYKDRMLALKRDVLVLEMILRKRLKKLYNHLKANGVDFTCVCVEWLLCHFCISLPIHTVFRVWDVLFHEGEKVLFRVAFALFKVHEKRLLQLDSDKDLLVFLKSMGNGIVQHDEFLKVAFYHLSAFRRSDIQAMRQQATRMVKQGSLSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCW3</accession>
    <name>A0A061DCW3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0405260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770228.1">
        <property type="nucleotide sequence ID" value="XM_012914774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCW3"/>
    <dbReference type="GeneID" id="24566583"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405260"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="842"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="973" mass="108894" checksum="1A7DBA50EA5B7FEE" modified="2014-09-03" version="1">MAKCRLKSIICAISAICFCRIKPIDALHCDFGDSGDFLSENALFLCRMDITYASLADVICPNRLNGTEYVWHPQPTSYKQAHLKTYLTGNGKFRAVPLSEVILAESKTPLVWFQLRASEVALKVNFMSADTYAITARRAMFICGPRKLVMSDTLQRQLDGMYTALQMQQLPWTPATPLTQELAKIGKPIGVFVLHRGDVHLPLQGCGSRPSPLFAADTEVTVDPNTGVRSCVADPTSRAPIGFVCEGRIEPEECMKSLLDKKGNILNAPTPYSHRNLHNSATWVIAKYFSELALPEFSGECRCIDNKTGEVKATMEIRSKTEYICDIASMIEHKDLQPTSSPWCSVVLHPGSTLTIKLPKEQIYSTSTGIAADDYQDENAAVDVAQDRLTDQSSPPPSVYEYDAEFHPHNLAVVRQLASFYDFNIYDEIMYQDALAGDALELDVSQISQGEVKLKYHLGKPLTLIGGHNSFLYHWTSKSTKYDSQDNIRATVNVSFAFSHEYRIIGCNRKAPRVFDRALSSHYCAKKQMGNGIGDIYECSYNQTTRMLKTGIYCSPDEELLPMNCDSVGYDLSSNQVMPFPEMVRNVTPHSIPGLQVFEIGFDNIPLSHACICVDKRGYETSRFILGSRHKQHYTYLIHRKNKLRKFIPSISPPRNRAELLVDGIGTSKLLTISYEPQRPITLKVGTTLVMSCSLDDKLQHVKYDGKIKAKWLPPELEEFYYTVKYTTNGTRLVRTSYKRSMVTSADGFRVSYEDGGWPTYHQINLESSKSAIVISKDPLYGKFIPMAFVCGKAPTLSDLSIVTDDGNTSDSSTHPIGQTTKWSGIYTWHVVEVAVETTDPYMQGCGVTYESDELFKPETPKLYNSTGERKFGCKIDLHKARQAAFYCPAPYVLDPPGCFNQVLVNGRVKNISDFTTALVASHSNHFVLLYSFSNLSGLGEEVRQTPPLECHCVTTKGVVLSTIQIENYYTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCX7</accession>
    <name>A0A061DCX7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0209530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767986.1">
        <property type="nucleotide sequence ID" value="XM_012912532.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCX7"/>
    <dbReference type="GeneID" id="24564341"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209530"/>
    <dbReference type="OMA" id="HPYDKSA"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600802" description="ATP-dependent RNA helicase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1956" mass="211138" checksum="A700DC3D0D461B1D" modified="2014-09-03" version="1">MLLYAAFLLGICLDLLVDPRARWVAAVAPGCRPPHLGCSPLHVLGGRGITGTDFNNPKCLQVNKSQCFVGPGCLGRSTAPTAVGAHRKGSSKGVADGGRRQSKKGQLPQKDQLLNAVRNDRSYGNRANGDGVDGFGRHRYPDGHDHGGGSSNYRGQGGRHKSHRNGTEDNIYRKGKYGSTIGSYMSEMDPKVDRRSTEGRGQKEVGIANGRYDTRAANTRNSYGGKGKATGKFAPVRYEAPGPGRWNQAGRKSGSYGEDRWLTKVYADNRGTVSGSEEPYDNGDHFMEPHVYKSAMGKQPHRGARYGNRVPHVGEGRARHDSANARLTGRNYGQQSRAKNTPAGDWRSPVDINAAISKFNRRLAQEHQQLLRASTERLNPLLSHVAHSNQKNQKLHLSADAQHKIAALGKKAKRMTERVESKQTTSPGQAGKKGAENAMKVVRSLPCNKIQQPDSPQPIKSKPHVASKSKRSVAADQDNDSAANNLHHGGDADRSDPPQRFNTLDISANDFNSLPLDVPGIRLMQCNKAPSAAVDSRQTKNGSPRRISLQEKVQHIKEVGFDGIVDINSLFSVSNQIFHRAKSSFNTTGADFSSLGISNAGLIKALAQKGITKATSTQSKYIPAISSFLSNNEGEYEPLRCMSVHAPTGSGKTLAYLLPLFQRVLHFGTTLPAPSPDAVVNVDDVIRSLGSLFAENILVLTPSVELSVQSHLVCKELYKAYEHNSSAGTVINSAAPKKAVTAPISRSPFSAIGAKILGKIAGVKAGHLNLEHAAGSGDKIAGDDTTNAVDGGATEASTGSSGPRFILDAEIRPILLIGNANVANQKRALKELRSKQQALRSEAIAALRALYSSGASATAMDPSEPIRLRRLVGVMFATPGRAHSLMKQHKSLDVQGTKYCVLDEYDGFLHVKRPPGSGSAAPPTEIENPDVKAVIDAILSGRAGKKPAAEGAPVNDRTGKYVLCLSASRLKDPPSCFGKLSTVTTQNMAGDAAHSGLQTLDDGDADDTRADLVDADAQAEATPPRNILHTMALYSVADAKLALLRKLLQAHPYDKSALVFCDSNGTAQFLESYLRRKFLAADVTVLNCRQGKLARKLSFQSVLQSNAAGAVGAAGKRRRGGGTPLRSVVISNQLNSRGIDFSGFSHVIHYDLPHGRSICFTSHDLADVTSYMHRSGRIGRAGNPGISISLVESRHLPVFRRVICNRLGAAVHNVEVFKGHLSPAVPGTMDVFPSGASFFRSASYWKRFYSNPNLKDFDWYGTLDDFLSSFNRSLSSKVPFDNAAGFTHKPAECVVINVGCGNSVLPFKLHELGYRSIYNLDFCAAVLDEMRLKDQALAMHWLEIDVSSDSYTVFGRDISGVYAGHQKVIIDKAFLDAYISVGEGESLSVARDRAKGYINATLSFMDADDVFLIFSLAQDYVVSELMRNLLLKDVYIDVYPLYGAEPTKAHMIQFLFAIYKRAPGGASARKQCMMAEVPHMPMEHFELSQLMKRIRNVKGALFLGSNVQDYKAGRRLTFDIYPKDMNNEVCFTAAVYDCVDCAGASLPSAAIIVPSGQEHFWQYATSEGNEELACQAGARRVIVLWLKFSSNSSKAAVTAKGFVNPFDACFGDDVLMQYIQDNMSDILLKLSLRGTERVTILKAGESCAVRAPRRLASSLYAGDIVVHEIMAHDEPNDRDKREVLTRQMVFSCGPQTVQSEIKYYVDDAGVEHFFDDSAPSEYIAAMLLAMAFLPGGDGVISVLGGGSGTLPRLLRRTCGGRKLHSVEVDDTVVEIARSHFGYKPDAVASISKHRLVPPPSEDVGLLHVSGDAFDYVDAATAGNVDVACFVVDINNVLDEAADGEASVDLLGKSTLMSPHPKFLDAQWLASVADVLAPVNGLLVVNVLTRSPSVLDSVLCRLSDAFAWVGTLHMPSDTNTVAICMTRAPKDATTVFGSYVSSTYAPLTSRSGGSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD03</accession>
    <name>A0A061DD03_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769190.1">
        <property type="nucleotide sequence ID" value="XM_012913736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD03"/>
    <dbReference type="GeneID" id="24565545"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309070"/>
    <dbReference type="OrthoDB" id="10475169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="113" mass="12578" checksum="748BDFAEEA4D0179" modified="2014-09-03" version="1">MKVVSKGEPLSNAEALAAVRKRLEEYRKQTAPPPSNEESGDVTMDDGTADDLPPLTALAGIGQEEPISAEMDEWYKRVKKLQRFHLDDASCSEVDADRTRFLEALERYLAPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD45</accession>
    <name>A0A061DD45_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769275.1">
        <property type="nucleotide sequence ID" value="XM_012913821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD45"/>
    <dbReference type="GeneID" id="24565630"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309920"/>
    <dbReference type="OMA" id="WNQFMYE"/>
    <dbReference type="OrthoDB" id="361271at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="89752" checksum="8DFA5983E3B75C44" modified="2014-09-03" version="1">MRALGRSLFQGRSKVLAAPNVKRLAKLSCLDLRKQIQDSARRHIRMRAVWTTYVQEVCKRVKNEAAEKDGESVDRFSPTDISLIFAAFAKSGKRDSSFISLLLEAMRDNVDKYDIRDFAVLYNGLAKVGMQADEMINGFNSNIESRITAKTSEKDLALLLNALLELRVRDANSIFVKASLAISSKIKYIANCHTLTLLLHSYSRLKGFATASDSPAPPPVEEVGPHRSAADDSTYQDDKAVGGSDTVSQGHDTANEPEKEQSPEATLITETTLSLLGRCADLMIQMRPTDIMYYYKSALNLIYSNSDGVTRQLYASMANMNKAHIRIREHVLEFEARELVSLLQALQNAQRLAGLESPLDGDGAVWVVNNEIRNQAPMLQEEITDELTYRTRVMSFAECLGFLKLMDPGDHRGVLVCRRLTYKVNKMNELNSWERYSKTDLWDLIHILGRRSDVATSTEAQELMVAITKNITGTLKLREVDAMCRLAARLGAKSNSLLKKVNSVTCRADCLQPTQAASLAYHLTGLGYIEHIQPILAACLQVDNAKDALHVLTALAILKVNRLAQISAELVDTMTRQIEVGKAELPTDELTTNKIALLRAAGIAELHGESTKYRLYPRLFSPVDHVALRNVRFTSNKLKVDIQLMTLEQCTEDIANSLAEFLAKFDEKTRLHRNYDAGDMIVPIVIELPGSTKVAVQVLMNDFYSGRRQMLRNDVFAQMRLMEDRGIRTVGCRADHYLQGDRTQFIANLLERCHNVANSETKTAKGELQEPQARFAKAHAVDISPQQPKLDSFSRFRRLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD69</accession>
    <name>A0A061DD69_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0310520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769335.1">
        <property type="nucleotide sequence ID" value="XM_012913881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD69"/>
    <dbReference type="GeneID" id="24565690"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310520"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600285" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="817"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="947" mass="106559" checksum="315BEE6C3FB29FA8" modified="2014-09-03" version="1">MKYPLAFCAIILQTIAYSRAAICDFNDPDRTLTYYPLITCSTDFNQFPYSPIICPREVNGIEYVWHPQPTPDEHAHLTTYVSRNGALRSVPLYEVVRSEAENELFRIESYPSQTELHFDVLARQLFVVTDDRLVFICGPRDLVMSDTLKEELDLLNVIRPKKTFAWNHGGTLTGEIRKLGYGLGVVYMYRGLSYLPLQGCGSRPSLLFAPDNVVSEDTSTGTRSCVADYMSNARIGFVCEGRLEPSDCFRSLLDENDKSIIDPLPYSYRHFNTYKPWVLVQYFDGLALPAFKGECRCIDAETGHVKARIEIRSKKEHVCDITSKVFRNHTAAIRGPWCSVLLHPGSILTIRFPIEHVEDSKAVTVLRNPPRYLFKTEFRPQNLDFLQQNINTYQASIYDVVLYNRALAGDALELDISQIPQGVVTLKYHADKPLTLRRGVNSFLFHWLLRPTDKYNLGPIRAIINVSFAFTHEYCIVGCDREVPSLFDPVISFKHCSAKYMGNGIGETYQCIQRSRLGVWDAGIRCRPDEELLPSNCASELYDLHSNEIALLPDSVRSSGPFTIRGFQVFALDLDDGAVTYACICVDQRGFEKSRLTLESYYDDYRYYRVRHKDGRNVVLPYMLLPWQEVGLSSEGSTSRDRLMLYDVTSSSIPVYAGAYLVLYCAGTDDIIIDEEDVGNDNDVQTSWFPKQSTLFHYTIKNTPYGDELVRVPHSFSIASNPGDLNVASVPTAAGVNELKIKLSRGAVLVSKDVMKRQYVPMTFVCGKKPEQSDVTEIAGSAISSDRSLQPINNIMGLSTGYTWNVVQVLVETTDPYMQGCGVTYESAGLFKPETPTIYAENGQEIGCNIDLHAAKEAAFYCPAPYVLDPPDCFNQVYVDGDVTNLNNISNSLVASQSNHFVILRFDGSQMGPGETLREMPPLECRCVTVKGIVLSTIQIENYYSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD84</accession>
    <name>A0A061DD84_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768231.1">
        <property type="nucleotide sequence ID" value="XM_012912777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD84"/>
    <dbReference type="STRING" id="5866.A0A061DD84"/>
    <dbReference type="GeneID" id="24564586"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211870"/>
    <dbReference type="OMA" id="GLECMAT"/>
    <dbReference type="OrthoDB" id="341976at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="146" mass="16411" checksum="46F41D01FE3F4348" modified="2014-09-03" version="1">MEADAAVSPPSIEIDDGTSCLICYEDLILSNAVAYKATEDAEWALSTFCIDCIKQLLATQYERYITSLRTTNCAKEQRALLERGPPVNISDHLGFPLAEKREVYALYDMGQQAPLSAKLEGSVTGEERERLWEELSKFKFKGDHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB4</accession>
    <name>A0A061DDB4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable exonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768311.1">
        <property type="nucleotide sequence ID" value="XM_012912857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDB4"/>
    <dbReference type="GeneID" id="24564666"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300300"/>
    <dbReference type="OMA" id="CPDKPLG"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000009">
        <property type="entry name" value="Exonuclease V, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="387" mass="44337" checksum="63F0B7716A14976D" modified="2014-09-03" version="1">MDDNEVVTKKRKTYRIAKKRKNVASETQDTDNAEDTKGTEDETQIDSSDLDGLIPDIEDYLSATMSAEEPNVVELPPVIKFRKNWTLSVTDLSSQLWCEKQTELMLITGRKRVTKEMEQGTERHEQLELEDHEVVEVAVETNEDSLGIKLLNSINLIDQLMATGKCRELWVFANINGYVLRGIIDQLEIIKSGPSQKKKVLISDTKTRNKKCKPSASQMQGAALQVQAYCIMLEKMRSGNEEFDALYKAFECDKDAPFVAAELVDEGCLAMLERRFKNAFMRLPEIATTMQLSYEHEGEVFNTSDIDLQESSTMYTIQYLCDFWDGHRHAEPVRKQESWKCKMCEYREECDVSPLPKEPRTKDALPSGQLLIDSFLKTRTQNESSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF0</accession>
    <name>A0A061DDF0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0312370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769520.1">
        <property type="nucleotide sequence ID" value="XM_012914066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDF0"/>
    <dbReference type="STRING" id="5866.A0A061DDF0"/>
    <dbReference type="GeneID" id="24565875"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312370"/>
    <dbReference type="OMA" id="SHCEPYC"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="411"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="501" mass="55253" checksum="070144E875C5772D" modified="2014-09-03" version="1">MYGQNNESDPARGHGAPNASSLESATHIPPGNPPVPVPGYPASATVPAYGAYYGYNGYAAYGNNYGVNYGNGPAAATVPPTPPVAAPLAPMAVPSTASMPPTTAAVSSAMVQPSAEDKLESVQRCHMHTKPDLNCKFCRKYKSAVHEMSRLAAQQSSQQPVDKPNQLPMTNSSTYNLNTLLLSNILNSEYYKSLSAINSYVDVMNELIQYADHAEPYCSTATRAPSTLFCCLHKLFTLRLTERQMTALVDCPKSPYPRCCGFLYLRFVLPSDQVRSLNGAVMSWPPQLWDWFEPYLMDDESFVVSAHPTRKTTIGEFCERLLVDDKYFNTVLPRLPMRFKNRHGPHLYSMAEHRRRRVRNLESIDDFAPGKSASAFISGDWVECTIQSVSDDYPTVTVSLTSGEEQTVDIGYVSLGKTGKSGSKRGRESESPEADGSGRKPGHVDRHRARDGSPGSTKSKEALLREFKRRESERALAVGKDYSKRPCSFKTSLSSKMDNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDG6</accession>
    <name>A0A061DDG6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769570.1">
        <property type="nucleotide sequence ID" value="XM_012914116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDG6"/>
    <dbReference type="GeneID" id="24565925"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312870"/>
    <dbReference type="OMA" id="KQVDQRY"/>
    <dbReference type="OrthoDB" id="361906at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27714" checksum="06E5E68ABBCF22C3" modified="2014-09-03" version="1">MAGFDVQSTSDEYLKTFQRHEAAARRGAASPDESSELSHLAKLKGDIDVAFSRIQQSLQNKSLTQGDWQKVIDLRQGARLKLDSANARIGDLIKMSASSTDRVLACQVQRYRRIFDQLTDEFRLLGKQVDQRYQSFTLFGDNRHSSQPLDMAVNTGKVVVEAIMDVESLTEQASLNLGVLRSGNERMARIYARVNTMVHEHLFDIQKLQRNINYVLLRNRTVTSLVMGFCLFLIIYKLVLSKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK8</accession>
    <name>A0A061DDK8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">At4g15545-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768521.1">
        <property type="nucleotide sequence ID" value="XM_012913067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDK8"/>
    <dbReference type="STRING" id="5866.A0A061DDK8"/>
    <dbReference type="GeneID" id="24564876"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302390"/>
    <dbReference type="OMA" id="IDIGTCD"/>
    <dbReference type="OrthoDB" id="5599468at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058936">
        <property type="entry name" value="At4g15545-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058935">
        <property type="entry name" value="At4g15545-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47383:SF8">
        <property type="entry name" value="OS01G0768300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47383">
        <property type="entry name" value="OS03G0659800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25972">
        <property type="entry name" value="At4g15545_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At4g15545-like C-terminal" evidence="2">
        <location>
            <begin position="180"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27248" checksum="FD7957008C7BF55C" modified="2014-09-03" version="1">MDMSSLDLTWLPSDADEQLALGFRIISNAYKTRVTSLEAEIRTVRAAVAEKSEHLAAFQKKYSSLEVQLIECTQRGNQLAEENRNLVAQIKKLQRDINRLETLKRAVLHSIQEDGTDVEADHRYYNADDLLHSAAPRTMIELSGADTVESAFIKRFGGKPGFSGTTSTTPTTNMNYEKGTVDGRNFLNVARATLNPDDMNGILSIIKKFNGQQLSKENALASARQLLGENNAKLYEEFKQLFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDN7</accession>
    <name>A0A061DDN7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulator of nonsense transcripts, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0303240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768606.1">
        <property type="nucleotide sequence ID" value="XM_012913152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDN7"/>
    <dbReference type="STRING" id="5866.A0A061DDN7"/>
    <dbReference type="GeneID" id="24564961"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303240"/>
    <dbReference type="OMA" id="RDPRRMN"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF322">
        <property type="entry name" value="HELICASE MOV-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="633"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1080" mass="120104" checksum="127770222AD919FC" modified="2014-09-03" version="1">MARPSKAKSVFSDNADLPSQKKRITTAATSADMGPSGSASLYKLEQMAAGFGKIPEFNKLMYNDDNVLMTLNVQLKNTRYKANMDVFMDKSAAVCKYDISVNGGEKITGTTTATNKKAARKNAARCMLMHMDKPTVEEIEEITKWMVAGHRNNIGAREEPVSKEFGPLGHTVTLRWRCDDHSFYGKGVSNSLKLAELYAMQDLYCQTHKFPTLQQEAKVLRPVKLNATPTITKASAKASRPEPIIDELSKADVCHMNTLRNSMVNKMKVKQHEVITQSRGGFLCTLTWEWLDTNGQVEKRTVAKQGTSKALAKAAASKAILVEVGVIDPVTREESSHASSIRSSITKNIARAVQAATEFVRKTNCSVWRLFMPQLVEALVQRGDRELVTPLLESITAADVEIPTDIWETLLSLSSIAVDEMFCKAILHGIKHLTLDSRYFISEKAQKVYQKQSWLLALEFNAEMCSNLASLQSRGGKDVVSLLCDNTKSQLPLMFLKGTVNSEYSKSPLREDDMVLLVPYNGVYQWGDGLVAIVSKHKSENYEASLTCKVVNRLKWDPTDAIYEHNRFGVFFVNNTTTNKRMMQALLAITHKMLPVNSNAQGYHYNKDLQRILIESDKDSVADLELNNAALPTSIPLTPSQSDACKSALTNPLTLIQGPPGTGKTQVACAIIDCWRQQTKEKILAVADSNVAADNLIEGLNSRGIHALRIGFGSESLLQEESLKRLAKYGRYKSLKESGYYKEANSLRMAMITEAIRQHQVIIATCVGSGNDILSSYSFPYVVIDECAQSIEASNLIPIGKGCKQLVLIGDHKQLRPTIISPEAAAQGLSISLLERLVSAQVATVHVLDVQRRMHPSISEFPNKHFYRGAVRDAVSESSRPPVRGFKWPTRGYNIAFIDASAGCPNSQFESNVGTSKANALEADIVAIVLKSIIEARDVRESQIGILTAYDAQKWMLKRKLNQIDSVKGQAIEIDSVDGFQGKEKELIIFSAVRSNLQKDVGFLRDPRRMNVMLTRARRGLIVIADKYTIMNDIANWRPYVEYITDRVLDIHISELNMFLDSPSNRLDGIVRQVRTGWYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDT7</accession>
    <name>A0A061DDT7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768746.1">
        <property type="nucleotide sequence ID" value="XM_012913292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDT7"/>
    <dbReference type="GeneID" id="24565101"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304630"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="98" mass="11389" checksum="B74B7DE549AD179F" modified="2014-09-03" version="1">MHTCVKHRPLFTTHDLYSVSVPSILVVVFCHYSLSRHNVGDNPDLGLMVKLSRLEILDKVFIRLLLELIRLHRIAFADSPVIQGCECVIYTIYYVVFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE00</accession>
    <name>A0A061DE00_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab1a, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0306340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768916.1">
        <property type="nucleotide sequence ID" value="XM_012913462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE00"/>
    <dbReference type="STRING" id="5866.A0A061DE00"/>
    <dbReference type="GeneID" id="24565271"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306340"/>
    <dbReference type="OMA" id="IPHVEIS"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="227" mass="25032" checksum="C798984163F452DC" modified="2014-09-03" version="1">MVSRASKDYDYLFKLVLVGDSGVGKSCVLLRFADDTFTDSYITTIGVDFRFRTIEVGGRRVKLQIWDTAGQERFRTITSAYYRGADGIVVVYDITDKVRLLGGRRDSPQLSFEHVEAWLAEVDKFAPEGTHRLLIGNKCDQGPSRDVDASDVEVFSRKTGIPHVEISAKTGTNVEDAFVSLATRLLADRLQRQPDGGQDSAPQTISLNDRVKSVFGGIPGFDKACCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE19</accession>
    <name>A0A061DE19_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CAAX prenyl protease</fullName>
            <ecNumber evidence="14">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0403720</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="14"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770070.1">
        <property type="nucleotide sequence ID" value="XM_012914616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE19"/>
    <dbReference type="STRING" id="5866.A0A061DE19"/>
    <dbReference type="GeneID" id="24566425"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403720"/>
    <dbReference type="OMA" id="FVIEEKF"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 13 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="16">
        <location>
            <begin position="73"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="15">
        <location>
            <begin position="237"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR97884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="448" mass="52257" checksum="AE3B60CF901792BA" modified="2014-09-03" version="1">MGIHNLFHSPFHFEFYLGALVINEFFEHYLNIRQLCVINKELRLARDPNRKGESGDDSDEIRKKAQQHVDVYLLSEDYHKTVEYARDKLVFQIISSVLQTVVSLILLFTFFGPKLWRFSGSLLSKPSETYQSLIFCGIKLLIDTTLDIPFGLYADFVLEEKHGFNKKTLRLFFKDLAISLVLQCVIGAPVLSIVIFLVHWGGDLFYIYVCIFAAIFYLFMLIIYPDLIAPLFNKFEPLNDDELKKGIEDLAGKLRFPLREIKLMDGSKRSNHSNMYFYGMWWFKKIVMYDTLLKQPKSQIIAITSHEMGHWKYNHVTKMLVFSLSQLFAIFYLFKLYKDDASMFRSFGYDGERAFIVGITLFGCVYTPLGALMHIIGTTITRYGEYQADNFAVKMGYGEELAKALVEIHHNNKSMIHHDPLYSWYHFTHPVLFERVYAIYKAMADMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE81</accession>
    <name>A0A061DE81_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0405380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770240.1">
        <property type="nucleotide sequence ID" value="XM_012914786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE81"/>
    <dbReference type="STRING" id="5866.A0A061DE81"/>
    <dbReference type="GeneID" id="24566595"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405380"/>
    <dbReference type="OMA" id="MRPRRMP"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00782">
        <property type="entry name" value="MutL_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="218"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="715"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR98054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="941" mass="104342" checksum="FA71FE44EF0BC7A7" modified="2014-09-03" version="1">MSITGLSTDRAASHRSLQVIAEVKCVVRELVENAIDAGANDIAVKLIDYGTTSIRVVDNGRGIKESNFEQLALRNTTSKIQNFEDIFTKLNSHGFRGEALNSIANVGVLDVVTRVAEEDMGWELKFKSDGTLREKNMVATKVGTTVTCRNLFEPYPVRRNLLLKNAKSQIPGSVGIVQQYALIHPEIRFAVSNVSSSSYQMQSLFTSPGSCNTIREVSEQIFGSNFVKNVVDVSLSGDGWSVEGVISTPQTGRQSKDIQILFVNRRPVDEMKKIKRCLKEVHRQFSSRNNVAYVLNLTIDCHQVDVNLAPDKRRLFLMQEEIITQQLKERMVDLYMMKMAKGSLVNDPLSLKQMQFSISGDMEHGDKAVSRGSSDEFNSRTHSVDKATQSASSKGESMAGMLTSQGTNQPAARGDLVLQSRLGLTTGAFQQTTSKLSEMQHNTYGDGDASEAVNSAFIALETARSGEGIMSKQSAGRPASVRFRETTSHQQMLDSYIMMPNHNTKPSTEHMGTGGYESEPRNDHSDATLVDTHDELNGTIQPTVQSNMPIRSQGSAVGTKSSQMDMHLDYKDTISNQRSTDTRGNAGVSHLHMAGETNVEVDGDTETYNRSSRPESARSSDPQASNDNSLQGHDDVKLDDSVNISSQGVATQESVSEGCFFNDDTLKVNMARLYNDNMCTTISQRTLNRNNYSENVPMLSDYGMMDPKVFLRMKVCGQFNNGFIVAKLEGTELHTEEIQYSVYLIDPHAADEKTKFEQYNASVKIHKQPLVHPRRVDLSPFHQQVVLANIELLKENGFDAFLVPKTEPSDEPKAAVQEPGIYLRSFPQLMGQILGEEDFVSFVHDLAQNGVAAPKDNKSSDARQFLWGSNTILPRPKRIWNILATRACKDAVKLGEPLSLKQMEKIKRGLASLIHPWNCPHGRPTMKCLITTEQMKKIING</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEB3</accession>
    <name>A0A061DEB3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0406080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770310.1">
        <property type="nucleotide sequence ID" value="XM_012914856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEB3"/>
    <dbReference type="GeneID" id="24566665"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0406080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0406080"/>
    <dbReference type="OrthoDB" id="10418414at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600308" evidence="2">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="11934" checksum="90B3C12656B645E3" modified="2014-09-03" version="1">MLLAFLLSLWIPTVHHICSELNSYNTYYIPIMSTQVTATVLCLFCAFVSLFIANIAIAWYLAYWMNYKLDFVLNYVGNACFFVGCACFVVIPFLTPPPVADISKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE0</accession>
    <name>A0A061DEE0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769301.1">
        <property type="nucleotide sequence ID" value="XM_012913847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEE0"/>
    <dbReference type="GeneID" id="24565656"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310180"/>
    <dbReference type="OMA" id="VDIYICL"/>
    <dbReference type="OrthoDB" id="2019031at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43405" checksum="B9ED59E3D4923051" modified="2014-09-03" version="1">MENHSRLSLYAMCGLVERLSQATLDDSSVTNLLRLKLLENLGEVTSPVVMGRVLYLLKNCSSMDRDFFVMITNHIYRNKLYPTGDVPRLWCRYFKFIGDNRLYHKALLDVLCSEFSEYVLRYLNHEPPSYPRRMQESVAIASWALAITAPDMPLEDLFERMLRFCSLPGIDRSVAIRVFWGASVRNTCLDRIDVAIIERLWEETLSEPSAGLRRKSHLHQIYTILRCLKLGGIEENGLTDRCLATLHELRYGHKDSKISTSQRYVSDVLVRLGVPHKVELLTPDLLSIDIAIEGDGERIALEVDGPLHFTCVCDAAEASSPMRTGPTQMKQSFLKHNGWSVLSVPPVKLDDSVDLSAAIASVDAYYKRLLLNSGSPYLRRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEI9</accession>
    <name>A0A061DEI9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM188A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769546.1">
        <property type="nucleotide sequence ID" value="XM_012914092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEI9"/>
    <dbReference type="GeneID" id="24565901"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312630"/>
    <dbReference type="OMA" id="WTRWPKT"/>
    <dbReference type="OrthoDB" id="10263628at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="2">
        <location>
            <begin position="125"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="598" mass="67082" checksum="6C07D46F93B5093D" modified="2014-09-03" version="1">MTLDGQDAGEPAATMDYDDELQLALKLSLEEYKWTTQANQKFGSHASGFFDSLKDDAHGRSGAQKRADDTVSMSFILDQMHHFHKIIKNEVDATHELNTHSASPAGSVEPRPSTTISRNRLADLVETLFGTEENRTASSENIRSWCKQGFCFQENPKLFWGLKQQYLGPCGVLASVQAYMLQCTLFHGGIYGSLELMQQSDAPENVLMELREVYYNFIKLEHPDFPEEWLHIPAILEALCAVLYNATPDSHYKVILFEPLKRQSMANAVHAIMYSSNYVYVEFDSISQVASHLLKNLHLLMCEMGVMSLTLSVLATRGVENVRNDMDDPSMPMVGIYGHSSQELVNLLLQGRAVSNVFDGEKVLQDGDKSLPYKLKGIPGVGCVGFLSEREASRHCAVGSYYKYPKFPVWVLASFSHYTALFALNMEYCKRTEEEMHSVNALTVWSCLDPDDNKFISKDLLPSLLDMLGVTALYKDACNHVIADSNLVLQTTFMDWYLSRTASRSGERRNENVTLFHYNGQDSMAPLSMVSVKHISQTELGELRKSATEDDEYAVDSTIAGFAKSPAVNLAKTIWTRWPKTLVDTLQMKSETRVAPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEK0</accession>
    <name>A0A061DEK0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAST LEU-RICH DOMAIN-CONTAINING protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769601.1">
        <property type="nucleotide sequence ID" value="XM_012914147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEK0"/>
    <dbReference type="STRING" id="5866.A0A061DEK0"/>
    <dbReference type="GeneID" id="24565956"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313180"/>
    <dbReference type="OrthoDB" id="413408at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="142"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="27569" checksum="81938F743C776A2D" modified="2014-09-03" version="1">MLRLMSLHLRRCLYSGNASLSFPGLSAGAELRCHNGASSLAIRRAAFAAVSDGSAAARGGTSKAGDDSRWMKKPDPPAESAPAGAAKTNITDGKFYFDADVENLSPEQQQQKEELIRELTRKLSGPLADENGNLPTGDDRPIAIEVDGPSHFYANSTKYTAYTKLKHRLLTRMGYKVLHVPYFEWRRLRGAKEREEYMREKLKEEPTEWIDPDDEAFYNKRMEALRRQTDGVISALEAESKASAANDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEL7</accession>
    <name>A0A061DEL7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0314020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769686.1">
        <property type="nucleotide sequence ID" value="XM_012914232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566041"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0314020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0314020"/>
    <dbReference type="OrthoDB" id="366871at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1482"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="490"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1544" mass="173929" checksum="5347774BAF6F461E" modified="2014-09-03" version="1">MAFLSVVLEAVKNENEVTTYDKYMTNKLETVISTLNSKIGSGRAGLVESVGAVKEWLEGYEGMVSEKINEVKHPIESIKDEIKRHKNKIREEEEFHISDQISNWTGRAVWYIEKAQKANTALEKIDNLLFDKLNHNVKLVLQGVTIFLDDAMNKDLENIYNTTETQMMQVLDEIYEIVENKNKAIQWYLRKHFTHLHEKFKKFNAEKLGLLKNVINEDIGRAFGLINSAFEGVQSSYKSQIFEQVSQLREASESLNIAFTHTHSAINQTLQIVYDDIERLETLEGIEKISSDTSILRGIADGVAFDELVSYFNQLDSKIMKPLKTAIEEIGKALHNIFPYAVEKLHLNEPLTNLQEVGKNAGSIPDLNNLQAQLHKYLGVYVDGLKGAKPTFSTVSEIEKIIEKIGRTDTTTLEGNELQSLLTFLADIPKAVSSHSKDLVTAITGAIETKVTDEIGDIAGAIKEKVLRCQNHLKMQDVTNHGLQGIPNSVVGFEKLVNDLKHKIDDALEELKVNVGTSNDQLEGLTVYGKLNELKNTIAGLRQKVNIVKENVDSVQTELATCILDAEKLVTELPKGVKMLINNVRDEIFAKMTVAFRNIQQAAKDLYTARKTQEVAALQKIVDDQITEIDDIITKNTKNNFKGFLAKINSSFVIHINHYATHLSPSGPKPSELTVHQKSLEAFAASISLRFTEFIVELRNQNDFKKVNSAFEPYRLALKHMLDKLSNSQHFDHTFNTNLNDLRNALNNFAPKKFGDPSPLLAPLKAGLSKFTEQLGHAYVNRYSGVKMGKLLEVKPSSKNQNVAKNPPSASSTPDYDLTPEGRNCAKVCLTIVEMVMDGLTDLSKKCEVQWSTKEIHRISGLGTFLANCGYVVSNSDKQDGELQRSDKMTGNQIRLKLKKQKFTKDAEVSHLLECETNKYPDGKQIKTLEFDFFDVLKCLHCHLETYYTLGHMASFTAKRNPCSVYEMLVWCAGFNYSLIYNTFLREGFTGLMEKPKKKIIQASDDGLELDAEYDDLTSYYVDVFPSKIRYGHITAAVDHICATSHDVLTRIIGHGDEYTMYGVDFCNNSLKFRYPTSAEECLDMFLDILRRLFPPLKYLETQCSTAAREYGWAGCHYGKDVQTTNWPCNEHSSTKVTCQPNGQAKCEPNCQPKSPLMSYLNDCLPGHLPHALTDIGCKAKCTTCPRSTPGMPCLTPLGFRGFSGTKREGRDISDVLGKFFDNGNLKVLFSLQAKTPSTLPEHFGFALSFVKGWSDVTDTRNHSIKQSIEASIADRSINLYEPPSTLTDKLRDAYGSKHIPHLNKPHLSVYADLSSLAVAKPCSVKDVNCAPYLSSLCIDSYHHLAKKQSNTYLSWSIYLPWTFWDLLNNLYNAFCSINCQDWGCRGCLRGDKCKKGEHGVVDEDKPSAICQCRSIVDCKGVAPTLYQYGFVFGEASTLNDKASPKTCSDFCSQLKNVLHSKYFERLFEECDNFLWKIREPFSYLVLALWLFSFLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEW7</accession>
    <name>A0A061DEW7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0404850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770186.1">
        <property type="nucleotide sequence ID" value="XM_012914732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEW7"/>
    <dbReference type="STRING" id="5866.A0A061DEW7"/>
    <dbReference type="GeneID" id="24566541"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404850"/>
    <dbReference type="OMA" id="EFARKCY"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="8">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="323" mass="36026" checksum="C0DF7A857DDF9057" modified="2014-09-03" version="1">MESAGDLPQPQEGMSEPSPAPTVYEGMSADELYELGKRNFKELRDYAEAAECFSRCLELRSSGNPLDHQLRECYLWYADSLLTKEEESQAMFPSDIDAGTESDLPTAESVLKAATEEASDETLAFEAFQIAHACYSDFLSSCTLQGAELEKEVLDASYCLVRLGDMFFTNNQFKEAAEEYERAVELRRKYHLGERHLASLYVSLAQCQMFSGNLSVSLGTFNMVKELLGRLLVGELAEDERQRMQDTLEDVDLQINDLRKLIDSTPAQTARPGSQCEAASLVPQTTDTFDERTLDTASKSAVINVSENTTGSKRRIDISGMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYT9</accession>
    <name>A0A061CYT9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0101100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765967.1">
        <property type="nucleotide sequence ID" value="XM_012910513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYT9"/>
    <dbReference type="STRING" id="5866.A0A061CYT9"/>
    <dbReference type="GeneID" id="24562322"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101100"/>
    <dbReference type="OMA" id="GIVRNWA"/>
    <dbReference type="OrthoDB" id="365191at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR93781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="392" mass="42758" checksum="02341FB472DC3F02" modified="2014-09-03" version="1">MADETLALVVDSGSYNIKVGYSGADAPLSTFRSVVACKLSFARWHALQTAKGRSSSSGTPRCRRPIRGPSCIRSSMASSATGKSPASASTAHRGRRALAERLWMHAFQNELKVSQREHPVLLAEPPLNPKLHRERCCQLFFEAFDVPGLYMAPTSLLALYGSSKTTGLVLDVGEGVAHAVPINEGTIVPHAIGRLDVGGYDVTSFFLASIDALDRHKLRDRYIANQIKEQCGYVAIDYENELKTAEKQPEQYSKRFTLPDGSTISTGTACFRCPEMLFSPEVAGSNAPTLAEVVYHTVRSCEPDMHKTMFSSILLTGGSTLFPGFLERCEKDIRAATNDNAPVKIAGSIKNRSTAVWVGGSIVASLQSFQQMWVTKAEYDESGPTVIHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYY1</accession>
    <name>A0A061CYY1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0101400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765997.1">
        <property type="nucleotide sequence ID" value="XM_012910543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYY1"/>
    <dbReference type="STRING" id="5866.A0A061CYY1"/>
    <dbReference type="GeneID" id="24562352"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101400"/>
    <dbReference type="OMA" id="PRTNKYP"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="6873" checksum="B4F2CBC5A61ED7DC" modified="2014-09-03" version="1">MAKSKNHTNHNQIRKAHRNGIKKVRIPRKISTKGMCPKFLRNQKFCKKHLYTPQGEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ61</accession>
    <name>A0A061CZ61_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0102400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766097.1">
        <property type="nucleotide sequence ID" value="XM_012910643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ61"/>
    <dbReference type="STRING" id="5866.A0A061CZ61"/>
    <dbReference type="GeneID" id="24562452"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102400"/>
    <dbReference type="OMA" id="WRREREY"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="626"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR93911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="679" mass="77372" checksum="5E7F2769B16A339C" modified="2014-09-03" version="1">MSRKRYKSASEEVPLELPLLNDVVANENLFKLRECLAEYRSEVDQLRGQNSAILRENECLRHLCSSVAGIWDVLSTELGGASLEPSDDNVGTHSAPEDAFLDLLSRTRLPFTVRRGAGDAASGDGPLSLEGEAVEAPGDGKKSSSKPDPGDQPTKDELDRFLHSHVEAFNRMKNVLLSRVKHLLQSTGGSPAAHGGVPETSPHNIAPHSQAPPAERSRLRVLELASTRLYDTVEELRDVVRKSNHRCGVLEVEVSRLNKLNAELRYSLNRVESCRTMSEPNSANSLVESLKYEDPPAPVIQGVEDVTVDMIVGSSLYKRLHELCKSQDERISYLEGLNLTLRTRGEHVALEYDRKMFDYVQQLEAIETELLNRVDEYESQVASYQEELRQQVERQEHLSAVASELKEERDSLIFELQEKDRVLHEHISKMAKVINAFSPSDDRVAAEPGLADCQDQLQNLSVELEEISGAYEEKTKQTDRLLQQMKEMRAFRDKYVALEASTREMEGKFSRAMAFCERKMAAAYQHKEDLMRRVEAYRRTWMASYHRCLSYEKKRDMAASALYECQSQLLVVERERNALRDRLAQVQAATQRVLVSRGSTDKCQDPLSEEESIKRENDVLRRRMTCTLCLEHFRDRCLSKCGHVFCDSCITRNLQSRNRKCPVCKVTFDRNDVRRIYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZP0</accession>
    <name>A0A061CZP0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0102020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766059.1">
        <property type="nucleotide sequence ID" value="XM_012910605.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061CZP0"/>
    <dbReference type="GeneID" id="24562414"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102020"/>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="577"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="305"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="753"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR93873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1351" mass="150438" checksum="E56FB8E52B25B470" modified="2014-09-03" version="1">MTLAPIPAGRPSGRNRVADHVRCIGAETRDSSQPVRRLIISKVVLRNFKSYGGTTVIGPFHKRFTSIVGPNGSGKSNVIDAMLFVFGFRAKQMRFSKLSDLIHNSQAYLQLNKGRPLDSMEVAVHFCEIIDRDADCDEFEVVPGSELVISREVHRDNSSRYRINGRTATQKDVSNSLKSFGMDLYNNRFLILQGEVEQIAQMKPKATKPEEEGLLEYLEDIIGTNQYLESIKGAQRCHEELQEQYQERFNRARVAQKDVEDLLEAKREADAYLAREKSLLVAQAVLARKELSLLADQQVETAGKLASLEERCSSATAELDAVRQERDTALEAIKGVECELAEASRAHKRLMGNLQRMIARDEELRKQLLREVTKVEEKTAGIKRANSNKPKLEREFQDKMRQSEELLKQLPGVQEELDGAERALESLTEALKPELLEANRQLSKHESELAPLQQACDQAQKEVRVLKSSIDLLETKRRGAADTLKTLKDIETKLSKSLRAHSDDLARQEGELTTQRALYESNKRQVAELESAVQARSHRCTQQRGEYESMKRELDEMMGCKDQYGYIMGLVATGKIRGVHGRLGDLGSIPPEYERAFMAACGVNVDVLVVDTPEVASRVFDELRKRNLGRSYAMALSVLNHDLKSQMEAFERNSQGDLPAGVQHLIHLVTPSDPRYRVCFYSALRETLIAPDLDVAIRVGYQQRRRVVTLNGELVETDGRMSCGGIRSPKSGGINTRADGGSVAQCGRAVLDASQLEQFLKAVEKEEAELKALRAQLAELTERQGMLSRTISELQYGVEMLKHTVVNEELQLAELSERMGATGADERASLDAETLAAMRSELEAKEQAAAAAAAKVSAQEKFVAEAYAAVDRVGKGRLKSAKERVADLESKLSEMRSAIERLRKQAASLQADADKCTRDTEKLTKEIEQHKVREGALERELNELEEEAAGVTNEMNGVSTQMEGLNAKLKELNEGLAARNRRIEEHDLKFVDLRHSIEELSKKLQACEHQREDRQAKLRGILEAYRKTRALIQRSNESQQLLSSNAPPRHADAPGSDGADDGGADKRDAGGSGSGQTSAKHMSHGQVAVKREATNEGGGGGAAESDEDDPATSPSDAALIPLNVNVLREKVEMLKKQVGAVPNLGVLDDFGVKAHEYGRKRHELCCIQERRDEAKRTFDQLCFKRKNEFLLNFAIIAAKLKEIYQSITLGGDAELELVDSTDPFTEGILFSVRPARKSWKQIQNLSGGEKTLSSLALVFALHHYKPNPVYFMDEIDAALDFRNVSIIAQNIKERTKDAQFIIISLRSQMFELCNQMVGIYKTADVTKSVCINPASFDVRKRTLEGESATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZR6</accession>
    <name>A0A061CZR6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0102320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766089.1">
        <property type="nucleotide sequence ID" value="XM_012910635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZR6"/>
    <dbReference type="STRING" id="5866.A0A061CZR6"/>
    <dbReference type="GeneID" id="24562444"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102320"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000061">
        <property type="entry name" value="ADP/ATP transporter on adenylate translocase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="111"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="208"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR93903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="300" mass="33759" checksum="89787B333BA1EED6" modified="2014-09-03" version="1">MENKNSFLTDFLMGGVAAAVSKTAVAPIERVKMLIQTQDTIPEIQSGKMPRYTGIMNCFGRVCREQGVGSLWRGNAANVIRYFPTQAFNFAFKDYFKTLFPRYDQKTEFWKFFAANMASGGLAGANSLLIVYPLDFARTRLASDVRKEGQREFTGLIDCLMKIQRSTGVMSLYKGFNISVTGIIVYRGTYFGMYDSAKAVMFGDDKNVNIFFKWAVAQMVTIHAGLASYPFDTVRRRMMMMSGKKSGAEIMYTSSLDCFRKILRNEGVNGFFKGAFANVLRGFGGALVLVFYDEFQKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZY5</accession>
    <name>A0A061CZY5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calmodulin-domain protein kinase 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0103000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766164.1">
        <property type="nucleotide sequence ID" value="XM_012910710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZY5"/>
    <dbReference type="STRING" id="5866.A0A061CZY5"/>
    <dbReference type="GeneID" id="24562519"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103000"/>
    <dbReference type="OMA" id="MSIDEFF"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="748"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="773" mass="87906" checksum="E4487FBB9717B11F" modified="2014-09-03" version="1">MSSATTKRLLKYESPYRSSRLNCAANNPIAVMTAYAESTDSTPLVQCKPRNAFSHQNDDHIAYPDEESSAQLNAVFNRFSPVLKGGWVTYRRKYLEGPTIGKGSFGVVKALFPMSDILALQQLLPTRLQLPANRLSQGIRCVANNRYEFCGMPLNPPTRAVKIMNINNPDGPTNVKDTLHVFREVSIGAWLDHPNVVKVSEIYTNGSEDISDVANEVFHSKSFACNVPDDCTKVYLVMEFCSGGDLTSRQIPEITKDETVARMFVHVFRALSYINTLGIAHRDVKPENFLWSSAAPDADIKITDFGLANSPLHTLTSRAGTAYYVAPEIVRHAPQRQYSVQCDAWSAGIMLHVFLLGYCPFHAETDVKTLMRVANEEIDWCDARYTMITPDAFDLLRRLLVKDPQSRLSTTEALRHPWLRRATFEVSNIPMTVEEATGIVDALTAFYRCPILKQLALCVMVGQAQDKKVEECRKKYLYLSMFCENEYFWINSTTVEKWLLCTREGPGSVGQRQHGERRPMYMCAEYIPGYGQEQFEPEGYAQGPKRRVILRQSMLWKSVSRLNEILSNFTHHKISISFTEFLAAQLMPHLLHRSDLILDTFAGLRSETPGRRSIRIDARDLRRLLNPMYQCSNSDLEDVLRQTQLVANCTYLRNLETEEESKLRVYNLLKPVLEPKADSHPMNLTIDEFFVLMKSSHDIDIILEALSESREMPHVAYEAVKRRMIVSKLQEIEACCAERRKRKKVCKTPPQNYIGIDKGGKSSTPNRRVPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D029</accession>
    <name>A0A061D029_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="4 15">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0105050</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="4 15"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766382.1">
        <property type="nucleotide sequence ID" value="XM_012910928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D029"/>
    <dbReference type="STRING" id="5866.A0A061D029"/>
    <dbReference type="GeneID" id="24562737"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105050"/>
    <dbReference type="OMA" id="AQTYSEN"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR94196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="217" mass="24907" checksum="C28765B7611775C4" modified="2014-09-03" version="1">MGRQPKLLTKANGVTEGTIVIVASVRVILLLISMKYVNENPLTFIGLYTASQLLDMVDGFVSRYFNEATLVGAAFDQLLDRMTSSYVCFLNAKQYPQYLEAFYAAMVIDVCGHWLHNYACALYSNTNHKDVKDANVVLRVYYQKKWLMFASIVMYETFFCALYLRPMYQMNIRIYYVLTSIMYAAAPLCAYKTLTNILQGMYGCSRIMKYDVEIAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0B5</accession>
    <name>A0A061D0B5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766457.1">
        <property type="nucleotide sequence ID" value="XM_012911003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0B5"/>
    <dbReference type="STRING" id="5866.A0A061D0B5"/>
    <dbReference type="GeneID" id="24562812"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105800"/>
    <dbReference type="OMA" id="TITNHVY"/>
    <dbReference type="OrthoDB" id="434697at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57079" checksum="B35220587ADA0BE2" modified="2014-09-03" version="1">MWTRQVSKVTLVYKAAVLAAKNRLPLCRYLNRCFVTSRSQERAEKAVRSVEQLCLEQRNCAETAQRASATFHNGSNDMSDLQIVRGMNAFANVGFANQVLLLVLSERIQEICENASPIRVAHTLTLLKRMHVTHPAVIDHVMLAVKRYLHNYVAELPDIVLNCSHVGCDDADLIEMFRSQAMLHYDTLGARSIRCAEALSRFRSEQCAVLDRVMDTYLTKLENLTIKQLVYLLSATSRSSKHEASAAITGSLLSHIASESQTPDNISRLLLLQSSSGVALARVLDTIMDSMELMMDNPKYVTDTLPYHIYLLCLLERGGHRSTLAFLERSLKNPVTLLSPSSACQLLYAISIVVRHHGKQVVEDRLGVLLRHMNSCYKRLSLKQQEELYESLLFIQAYEELPGSLSHFVASKIPSRLPTMCGGGVDLQLDTIEGVSYVLFGHENVARTALVCVSESEALTVLDDLPSVSMGPRAQQYSRTLEHLFSKNHTHGCVPAISYNVSTNLSRKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0C6</accession>
    <name>A0A061D0C6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766467.1">
        <property type="nucleotide sequence ID" value="XM_012911013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0C6"/>
    <dbReference type="GeneID" id="24562822"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105900"/>
    <dbReference type="OrthoDB" id="365741at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595628" evidence="2">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="291" mass="32474" checksum="0745EADFD2DC4EB3" modified="2014-09-03" version="1">MHRSLFSIFLLLPLLCSAAKEKVLPERQDSKTNDYLTTAFELFTKLSEGSKKGGAAIAAKVVSDNVDKREEFFQAAYATLDRSPFSGVLPRCLCKVASCALAPCYSMCTRREAVNSDIFDCSSCIGDCIPMFMRCILKFIFLALFALLQPAASIANIRSLLEEMRTKEASIIADSIDVLQEEYDYSEDVIKKAFERCREESGVSLVPCFIDSLHVQKLLHDHKYHLCAFYYVLSVAADCAADCFDHYNVNCLTVSLAICVGKPMPSFINCLKKGPHQYSSYNNESESSNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0F7</accession>
    <name>A0A061D0F7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate-binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0104670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766344.1">
        <property type="nucleotide sequence ID" value="XM_012910890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0F7"/>
    <dbReference type="STRING" id="5866.A0A061D0F7"/>
    <dbReference type="GeneID" id="24562699"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104670"/>
    <dbReference type="OMA" id="FQEFYYL"/>
    <dbReference type="OrthoDB" id="2135133at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595631" description="Guanylate-binding protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate-binding protein N-terminal" evidence="3">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1134" mass="127516" checksum="851B9A726EC53FF7" modified="2014-09-03" version="1">MSFIMKRHSAPWKAAIFRVLRIACLSWSLTTCGNAAASLASKDSQTGFTAYGESCAGAGCIFDESSVGADIHEFCLVPGVGGGRAVQLVRPTDDHLGLELVEEGMQLLRSIPKPIAIVTAIGSVKTGKSSLLNVLNEHVLCAKGDQLDGFHVSDSVNATTRGIWIWSEPIEVESRVLQEHIDKGLTSKSSAFDHLVTVMDSLMGGTLRAKLTAKGRADFSKRSVDRVNVVLLDVEGFNSTDGFQRYDEALFTLAATLSTELIYLTHKVLDSRDLLDLQHMLQTANSTIVNIYRSLSNAPSVVIGEGNYARSHQGVSVIQQAGVAEETGCDACNIITNVSRTASGERLGGGLLDLQTRTTLTMSVQGFNLQLQESALDYLNEVINVKRFDLSYNDQRSFLANLSQMREQFVRFFKADSRSRATASSPDQLATDLISRMTSGYKYVIPHVFGAVDALLMSAPSKNNKTPRKCELARGYLEQVLNFKIRLFKRCLMSPKTRVSFVLNDTVHMAGNDFGDLLDHLVKTLNDSLKAGSVDYEGDFRLTRANLVKNDLVDLYAQELGGFTRKLPIPLPVELADFNEVTKTKYIQLIELYASYDITPDNYRALKADFEGRLSKLMEYFDHELHEITLKHCRAVLPGVKNAISELTAQLKLPVLPSVIEDLERKRLEILDIFVQAVDANGVEYSTTEASKAVAVEVVEFIDTQIHDLYRENESEINAVFQEGTRRAIEFYVSNSDRNAVEKYRVSSTDFVESVNAWIGGSYAAYYQVVGDFKEMDDMNRKSLEFLGKQLSLLEKESMDHWDDVCRHSLSQTMHRFKSTFDVQLQQLVPFRPAPKPILRIAIEYLRARGWAAMAELHCGTSQVVRNTQPIFNRMVDEIGQNAVKSNDESVFRHFHKEFMIMYQEAVERVDHVYHFYQLKKHMHWYAKRHVFAHIKVVDQLLRPKRAAEELKKNVDVDVLENITDAKLLREAKSLLLIGSADASKTHVIDASILLEDIVEQWLSERLYPRIRNDLMIRMPKLSTFFAMAAVLVCSTLMFNVRNARLIYFLCCIDVIAFVHMMGLRRVMLLLGMAARWAKNLLTMAIATLGVSWSVAIAMTLLAGSLLWRQVVRRMPAILGGRRRSRYLLLKQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0M8</accession>
    <name>A0A061D0M8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766537.1">
        <property type="nucleotide sequence ID" value="XM_012911083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0M8"/>
    <dbReference type="GeneID" id="24562892"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106600"/>
    <dbReference type="OrthoDB" id="366513at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="234" mass="26112" checksum="E707CCA5E4715BC9" modified="2014-09-03" version="1">MMYLSLTRAPRDLKEAIDWLVALKGDDPKNNLRAISDAIYNLLESDTLGLKMLPALKIIRRISQRFLQKQELQDQVFVRASARKMNKLVDKTPGGVNVPKNVTPETIANNVTHVVVGAEIFLNDIKDLDEYKSAYSSEATWSNSCSTKPEACAVIFVGIAPILFAGLRYVRDASLAAKLPISKYTGRGRLDDIMKSLGYKDTQYKERITRSDILTALRAVDHQTMATLHDLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D158</accession>
    <name>A0A061D158_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766737.1">
        <property type="nucleotide sequence ID" value="XM_012911283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D158"/>
    <dbReference type="GeneID" id="24563092"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108490"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="399" mass="44607" checksum="22F8006B7ECA288E" modified="2014-09-03" version="1">MAVMTAELADVKTANKTCCGCNKRWSVSAEHFCCIPGCPGCKIMCSTKGRCHCNVCDCGCQKDNDVREGKTRCYQSTSNVCPKCKTKCKDVQNGERCICFLCNCGCNGVNCGCCTWCAFNNCTGVCDREDKHSEKCKENKDSKSKEYESGKYYCDKHLDGKCIGGICDTIYYTTGTCRAKCQYCGTLCGQHVFFLQCTIGGPIIGIILVNIVVWLMWRDKALKAVDKMRRSFANRPGLFKTRWMTFENHSAYRYGITTTQKIKVHQLLSIIIYIKPIITSITIKNTDASKYDHINYDKGCTTLKPILTSPPTPITPDQPNKTNTMHITTYNRPSTGNTKNSKLGGRQVAVSDLTLRVVTQHQTLAEQVNCSHRHHLAPREHVAASQSQQLRQHETVCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1D1</accession>
    <name>A0A061D1D1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome 26S regulatory subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0107410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766629.1">
        <property type="nucleotide sequence ID" value="XM_012911175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1D1"/>
    <dbReference type="STRING" id="5866.A0A061D1D1"/>
    <dbReference type="GeneID" id="24562984"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107410"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="4">
        <location>
            <begin position="957"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110215" checksum="973BE256D658840B" modified="2014-09-03" version="1">MKSKRKDNLSDADLAYKEELDTLVRQLIESRLEDAAAQPILQLLVEHATRSGGNITSVPKALQFLIEHKAALYDLYSAHMSGTGDDSYSVVLLLELMSFLDAIATPDDATEDQKKPAKEADKFKLMLYKVEAVMAARRMLANPATPAEVREKIASRKIQDWGNEYLTSLSTQIVAFFNLPETRDVYDSLPRSSDQMDVVAAEKQSVLQKFDTALLIPETLKFAEEITDYFFQNGFEYDAIDLLLEVDLIESIRRKCGNDHDLITRVTSYIISISAFGATYVETRRMLVVAYEMLLEAGRSAEALRIALKLDDQEKVRDVIFGCTNAATRRQLAYICASHGKYLSLAEKGGAESVLTPEDLDEIRGISSGEHLSGFFLILATELDVIEPKAPQDIFRSYPATKLNANFNITDGRLSKNMAFDSALGNLSHTFVNAFVNCGFGTDMLINVPDSDWVFHHFEYGLLCAAASVGLISLWNVEEGLSKVDKYEYSSNPYVKAGSYAAYGISSCNVVPESDPLSGLLLDKLETPDKTLCLGAVLGVAFGYAGTQRESLLEYLVPIVVSDETQYPHECSAMAAVALGLIFVGSGRQEASEAIVQKLLDLPDNTMDMPAKCQFACALGILQLGRMDASEVVIEALKAVEGEHGRIAELMVEACAYAGSGDVIRIQQFLKCCASAENEPKAKEAKQDADDAMEVDIPPKSPKQSAIDAAVSAVKNASETGGHDTKKEVKPARVGFKLDDDTSSAKRSVVNQSSVAILGIALTALGDSVGCAMLLRLFEHPLAFGSPCERRAVPLALALAYASNPSPQVIDALSKLTHDVDYYVSMHAIFALGIVGAGTNNARIAIKLQNLARSHTRDTTVTFIIRIAAGLLHMGKGTTTISPLHSEGLLLRKTALAGLLVTMTAALDMKNTFTHSMPFTLLFVAPAIRPRWMLTLLPNLEHVQVPCRVGNMVETTGTVGKQRRISGFQTHQTPVLVGASERAELATEEYVPCTTVLEGIVIVEKNDNVTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1K5</accession>
    <name>A0A061D1K5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0103220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766188.1">
        <property type="nucleotide sequence ID" value="XM_012910734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1K5"/>
    <dbReference type="STRING" id="5866.A0A061D1K5"/>
    <dbReference type="GeneID" id="24562543"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103220"/>
    <dbReference type="OMA" id="SDFFYHG"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="613" mass="66542" checksum="A6608AB4A7C2D195" modified="2014-09-03" version="1">MKVHWVTRLLIYSIIATFVGPFYDNWSSTEKYLYRQGAYIDACVTAPPESAVQDTWYCEEQRQKLSLLLPISRVAECFLSVVIGIFMDHVGPRLTAVVGVVLRVIGWTLMGFAVSAKGGLIAAFFITGLSTNFIVFPALTIGMYNERFRYVSVLVIGMLGGFASMLMKLKLMMLEYELLTPQQLNYQYTIVFIIPSLLLCIFFMPGKLESVNAPTTKALAPDAPTSDLPTTEAPTTEAPVTDAPTSDALTTEVTTTDAPTSDALTTEVTTTDAPTSDALTTEVTTTDAPTSDALTTEVTTTEVTMTEAITTEVTTTDAPMAEVPTPEAPTSDAPTSDAPTPKVKDIAETTTAVDGTSINMILDDLVQGADVNIDIAECHAEKTPSDATAAPQWTVKGLLYTLTRKEVIASLLYFAFNFSSITYVQQTLTLMHKDNPQLVTLSEYMIQLSAVPCLVFAVLYMYVDPIWILIAMNSVGILMHLLLTSSNYYAGVFLCIAIMSTYSIINTQVYNYLDSVFDATYMGSIVGALNTMCGIWMLSQALIVESLMSQKAIIVTTSIMAALRLVFLAPFCIFVALRLWDNAAESEESCPGVVSPKVVASVPLESVAEGIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1M9</accession>
    <name>A0A061D1M9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sas10/Utp3/C1D family protein, related to chromatin silencing, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0108510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766739.1">
        <property type="nucleotide sequence ID" value="XM_012911285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1M9"/>
    <dbReference type="STRING" id="5866.A0A061D1M9"/>
    <dbReference type="GeneID" id="24563094"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108510"/>
    <dbReference type="OMA" id="KSMKPVW"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="6">
        <location>
            <begin position="565"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="637" mass="72433" checksum="2ED9730CF46DBF3C" modified="2014-09-03" version="1">MARKTAKKSATKRFKGNEAFIPLAAVSEDEDSDAAEFEAMALPRDLPSEDSEEELDGDEEDDDDDDDDDDDDDGEDDDEDADDEDDDGEDEDLDDGSDEEEEDAGTKKGASWGKKLGAYYDEGSEESSDDEDINDRIAEAERIARDLYDGVDDEDAELEDMVEEEDEVDTETTALDSILEDLSASLRNQSSLVELPPAFHQLSDADKRQYVEDEHPEFMALLKEFKEKAELTNEQVLKIVNDMGVPKKCTKDGMEYLDVRNELMLMYVTYLSYYLLLKTHGVPVENHPVINRLLEIRIMLDKARPIESRLQFEINKLLDDNMAKAEGKALRPRLDLMEFDEREQSGVYKPPSQLPLAETDAYAKHQKKLQRKEKVVSGRRMLDEAREMQEEDEDEPTDRYSSAKAAKMVKALLERERYEMEHMRRLPMNKMAKKELREFQKHQRNKQGGIMLDELSSFAAEALTSGQSKRDVLVGMNTAAQIMRQDILETEKLRASDAYFKPHAAKRSSKPKAASAPMTEAPAPRKSEFDDEFAKMKRHQTELKESLKESKSEGKKRKFEREEVEGKRGAGADILRNKGLTRQRKKTAGNARVSNRMKYQKKKTVHSSMVSGTKSETPGYSGETTGINAKKKKSVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1V7</accession>
    <name>A0A061D1V7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial phosphate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0110590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766947.1">
        <property type="nucleotide sequence ID" value="XM_012911493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1V7"/>
    <dbReference type="STRING" id="5866.A0A061D1V7"/>
    <dbReference type="GeneID" id="24563302"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110590"/>
    <dbReference type="OMA" id="YKGAIWL"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000138">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="218"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="33785" checksum="3A78E9C35914CDFB" modified="2014-09-03" version="1">MSGKQSASANQGHDASYYGKCMLGGTLSCGLTHTLVTPLDLTKCRMQTNPKQYTGLISGAKLIKSQEGLGGLMRGWQPTLVGYSLQGLGKFGLYEVFKDVYGGMLGESKAKQYKGAMWLAASASAEVFADVLLCPWEMMKVKIQTAPPADKWSNNIFASTRRMWVYKHETNFPFGSLKALWSRQVPYTMAKFYFFEKVVGIFYDKILTREKSSYSKATQLSVTFASGYIAGIICAVVSHPADNLISQLGKEENKGKGVAKIAKDIGGINLFTRGLGTRVIMIGTLTGLQWWIYDTFKAYVGLQTSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D265</accession>
    <name>A0A061D265_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767022.1">
        <property type="nucleotide sequence ID" value="XM_012911568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D265"/>
    <dbReference type="GeneID" id="24563377"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111340"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="114" mass="12391" checksum="DB8A4154FE51C05E" modified="2014-09-03" version="1">MSYECMQEAKGDGMVGVGVWALNLVGWPKVFEVGGFIVNIAPRKMCFCSDGSGDCKDPARCIGIGLAIAFAGFIGFSALLVLVLYIMGRQYDVSLGTIFRQIRDGFRDSKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D275</accession>
    <name>A0A061D275_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767037.1">
        <property type="nucleotide sequence ID" value="XM_012911583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563392"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200080"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1792"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1854" mass="208121" checksum="EEDB87FD2FD00CE8" modified="2014-09-03" version="1">MSHHVHPKSKSLELLRLINAMTSINHYNNLLMDARKKQLNGINDSRIQLGELAGQLGGFVGQSESVKKAVVNAIIAKINSNEELKHLYSSLVTNLSESVKSAGQADDTGKISELKSKITTEIKLTEETMKKLKPSVINSPSSPSPSAESDKLHSKLQALEKVEKLCENYEKLKTSDNNPKNLLDNLCDGLETFLGFNSASKGYDGTGIVYSDLDRLCDGVMGFLSGVLGAVKNENEVTTYDNYITSTNINSVVSKIHDCIGKGPEAFKEAMADVIFWLRKYNFVLQEKTSELTAEISKFMNSKIGYDYIKRVSGSSTKSLREQLSDWTNVVGEIQRDLTKIETENINALDKTLRNNIMHKFEPVKTSVQLLLESAQNDALVKQATKVDAELEKQEKEIKKEILRQSISITDTFKEGFQEVFRNIRHLSDVEKTQFGSIKNRLEEAQKFLNTKFDYEYKSHVIGKFEDIKTVVKNVHAMLSVQKQGLEKLVAYAWQHFEQLKINTIKKEPGNGEDNSIGKKWEELQTQIISIVGDINGTGAGHNKNHPSHDGLEGIQTRTKEWAEGFTHFENVVEKWVAEILNDGKGMVIDKVNKYYGNITENDKTAISRVFKEQLNAKVIKTNGPLTVRVMEGRDSIQQNINAVQSSCDKFAKVLHEKIKAHDTLVDIAKSILEAINLQVKTTTKTNDARDISDAIRSTLEQLVGMSRSASLEIKSVTAENSTYSLGKRVDEALKEIDNIRKEFVAGGEGRNGKFITAALITVNDKIRLLEPILKNEATGSLRATANAVETIVTELQEFTKTKNTNGSIEQKKQAVVDKMADLKSQIQSHISVILKAVVDADAYLEAVINDIQDALTEADIKANQAVNQLKEELTEKVDKAFHIINIEVKSLFAKERTAHLSALKTLVTRQLKIITCTVNKNLNTGLKGFLKTLSGDYVDIYLAGYKERPKHLPPKAQKTNPLDEVKTALERGEHGDKVATLSSTFKHYSEHIFDYLDKDLKHNFASQPQVIGQYDQTVSTIRSNLTDLLTHISAHKHFDHQVPEMLETLKTSLTSFKSSHFGNASYPVLDAFPRSLEQFVGELERMYVSRYDGHKQKVNMGKLVISDGDKGEKLTDDGRNLSKVFLTILVTLKAGLDELKQNAPNAWRGRQIYLQDSNEDENSFGQFLNKCGYKVSKSHDSHEGHLRNKEQCKGQYIHDGLLVGDKQHIYHSDKNGKRALEILFDYLETYNDLCHLSTLTSKRQPCSVYEMLAWLSGLTHNPVHQSKLSVAIMNVLEELYKRGREDEGEHGDVLAVERQADGGEFKVSLVDARSVSLEAYPRDVSYDELWAAVTHICSTSYDVLCAIAGHGDEFTTYAVDYSNNHMKFNYPQNGEDCLDMLLDILRRMLPTLQYLYSQCRLSNGLNGWQACKYGKDIMTAKWPCKVHPSDEPDNKSNCQAKCKPTCQAKCEVTCQVDCQPTSPLMSYLNDCLPGHLPHQLTKIGCKYECSNCSTSKKGKPCLTPLGFKGFSGSTRMGKDICEVLTKFINIKHLTGLFTLIPKPPSTLPEHFGFTLALAIGINATSRTNNYDPHAFRGVFAASIYEQTINLCTDQSTLTNALTDAYGSPSPTHGVCEHAHVRNLTASDSCKGKTNLELECAPYLANLSVDCYRYLGKKHSNLYLSWAVYLPWSFWTNLKNLYDAFCNIYCQDWGCRGCLRGDKCKRGEHGSISDASKQPNCQCHSIVDCRGVAPTLYSYGFSFGDPSKLQNEHYPNTCADFRKQLKNVLKSEYFTKLFEECDKFLFTIREPFIWLNVALWLLSFLYLLHIMVIRLDLLHIKSHLHSPSSHRIATQSLLAAARVKALNKVLYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3A1</accession>
    <name>A0A061D3A1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767407.1">
        <property type="nucleotide sequence ID" value="XM_012911953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3A1"/>
    <dbReference type="STRING" id="5866.A0A061D3A1"/>
    <dbReference type="GeneID" id="24563762"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203790"/>
    <dbReference type="OMA" id="FCESHAH"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="846" mass="93098" checksum="372A030A4E9154B1" modified="2014-09-03" version="1">MKKKKERDFSTKKVRVGREQFRKHASSDARLLANIGQLKKTVKLSTQSIVVNKDRLNVTSRRLTLAELIGKSRHSSESVQLHALSGILEFSRRFRDDTRLNLFSIVQVSGACLLSGHHGVRKQARSLLLAVLEQFNIKSARNAANLAITAGAVAEGSGHGVTNDASGSSTAHGAGGTGDKCEECLALYLFQGVVSSNDVIRSDVYRTVISILDRFPFMIANHVDYLIAKLVKNHPDPPTSAHIDCLYALVKFRQGCEDSVRPALVDYLCKVLEYTLVEGPSATSELACLSVASMTVKSLKAITLNTAGIRYDDARLLKALLCCNLYEYEGLTERGQQTLDALFTEFVLSRSELGLMCADIFRSHHLILMVPLIHLYTLRNTICQDHAPRIAGIIMRAMAASTEHFELQNIGALKPEWREQLLRLMPTDSAVLHTLRAALQESMPYGSQHLRQFDVSTIENANLTVYSGDVSCGNAFEELCKGLIESISQRIEMLPVIAAARMVPLALCTEVFCHARSFSKNFGYLKHLPADYEVRREIPCDLDGYLVRLIDTADKNAVALLLTTLLHMSRLPDKIPEREFAAKFLNPDSIRQMREHELSLVARVVLNCSHSAEIVPQLMDLLRLRLRDPTLCPHDAAKRLIDGLLYHLFGGEALTTQGPAAGIDEHLVQVNRVMGAICGESSVLESQMTTDSLDLIEHAMCSCIVGSLERLLKSPSNNVWTVAEGHAIIFRRCLIPECEKLLEKGLCNVALCILNTGLLPHLRSCATAVQPSAHTTGAAATVGASGTQMLVEHALPQSDRPEWMQKILESNAVQRCSEALLNRLPAGDNAEATVARLCSTVAHILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3C7</accession>
    <name>A0A061D3C7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766773.1">
        <property type="nucleotide sequence ID" value="XM_012911319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3C7"/>
    <dbReference type="GeneID" id="24563128"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108850"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="6065" checksum="2D79BBC31AD5C5DC" modified="2014-09-03" version="1">MLSVLGEAEGTGSGSGSVEVGELRGVGAAAAVVEGTGSHSGSCCSWLRGLGGEDELGEGQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3P3</accession>
    <name>A0A061D3P3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767389.1">
        <property type="nucleotide sequence ID" value="XM_012911935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3P3"/>
    <dbReference type="GeneID" id="24563744"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203600"/>
    <dbReference type="OrthoDB" id="366034at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="375" mass="43026" checksum="FC964B120FF97F8B" modified="2014-09-03" version="1">MATTLHRSDPKLSAILLRNYSYIPSDSIQECLSGTPLRVDGQEFDISSQAFLTPLNFKPLLCCVLNACCQHKFLLADRILTAMHSCFAVSPGLYEALVDGEYVNNMVLILENICKIKDWDRSVPCVRLLNMCSSAMLRHQTRGNIDQLYRRIIRKICNSIAKFHITGEMNSRVLYKQLSGRKGSQYDIRAAQPLRGGGFFEDLSRVPFKWCVLFWWMEIFAATVGINFYIDIEPFRRSMRDTRTLVIIAIAKHYAYQRFGCSTPVKLESIELDRNVIWRECSILVTFTDLKVKSLDDQFNGFRWLIALDLVIELPLISCIDTHDNAHSLKFYFDVNLAYLKSSSQSCQITHGQSTCLRYLVWDFATKLLSNTAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Q5</accession>
    <name>A0A061D3Q5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767399.1">
        <property type="nucleotide sequence ID" value="XM_012911945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Q5"/>
    <dbReference type="GeneID" id="24563754"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203710"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="449" mass="48823" checksum="8DE3AA7987B5AE8C" modified="2014-09-03" version="1">MVYNSLTEAPHNVKEGIDWLVALKGDDAEKNLVAMGAALYDFLAEKPVGHTHVPALEKVKRVTKTFMEQEGVKNVWPFKVMLQRFIKPVNTNPSWFSRLFNAVKESDYKNVVKTRGLTANTIAGQLSKAVDGCERFLDKIKVPDQYESSYSSEATWEASCSKKPEYCAAVLVGIAPMLYTGIRSLLKTSEDEVLRSAPFICGKSRIPTILEALGFKGAGCQDDMSRKYVLKAVGNVNFRMLDTLYDLSGFWAFYGSSTTDVDAEPSVDGEGEQSMIPEAEPSVDGEGEQSMIPEAEPSVDGEGEQSMIPEAEPSVDGEGEQSMIPEAEPSVDGEGEQSMIPEAEPSVDGEGEQSMIPEAEPSVDGEGEQSMIPEAEPSVDGEGEQSMIPEAEPSAEPVKPEVDEVEQPVKVAKAAKVARSVKAAKKAAKKVSKKARQKKQKKQQESAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D429</accession>
    <name>A0A061D429_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Repressor of RNA polymerase III transcription</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767494.1">
        <property type="nucleotide sequence ID" value="XM_012912040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D429"/>
    <dbReference type="STRING" id="5866.A0A061D429"/>
    <dbReference type="GeneID" id="24563849"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204660"/>
    <dbReference type="OMA" id="FYVIENI"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23523" checksum="97D9E0E5B81DC144" modified="2014-09-03" version="1">MTLVENSDLSRLTALLDRFDASDRVFDVKLELLAFPAKKSEAAGRQHPHAEHFSYIMNHCFPDYSFSHLGTKHFKQLKNLPAVINNIDYNLSFIVERFVPGFAKDFWDVIKDIVPLKEVDIYTYDYCGEDGPFNEGSCLQSFNYFLLDKRQQLVLFLCCVTTGKCDSVQRMQDEQSFTTPCYQETVSSCNEGDCLSDFEVPETMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D434</accession>
    <name>A0A061D434_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767692.1">
        <property type="nucleotide sequence ID" value="XM_012912238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D434"/>
    <dbReference type="STRING" id="5866.A0A061D434"/>
    <dbReference type="GeneID" id="24564047"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206640"/>
    <dbReference type="OMA" id="SHNPDCD"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="221"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="488" mass="54106" checksum="4C7FCF6AFA6A6EB3" modified="2014-09-03" version="1">MASGIALYSVPYDSDAESTEQYGKSYAQMLSEDFNEEGFDEPNLIKYLGKGPSGEAVILVVPSVSARVRSNHEDALRLMVKKLNRFCSAKYSLLVCQTCTTWSDYNSYNFVNQWYDMLPKGSKKNLVKVYMIHSAYTTKTMLTCMTPFAKARVWEKIEFVDKLGDLLKALRLDTKNMLRNFPYSVQRAEEIALGIGMPLSVFGTEMWVLAMRVGCPFKGFPLIPPAVAHVLAKIESPEIIDTPNLLNLQCSPDVLYAAVGAYELLGEGCAVDSPETAVALFRLLVDTHVGGLIGPKAYITLKNALLQGSSNEELVQMMAKVTNEFQPTQKDCIFCIIKTLRAIARRASRNGMTVKAVSKIMAGSFFRPLSPDPYCFKAIQSSEMVLGTMIEKPDMFFKREKEPHEREEGRTKTVKHSSHAKSSSSSSAAAGPRLAKSPSMRAREELQRIAQRKEAGRGSASPRPAERTPTAAPATDEEESEQITEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D445</accession>
    <name>A0A061D445_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767524.1">
        <property type="nucleotide sequence ID" value="XM_012912070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D445"/>
    <dbReference type="GeneID" id="24563879"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204960"/>
    <dbReference type="OMA" id="CMIAHGY"/>
    <dbReference type="OrthoDB" id="364080at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="559" mass="63609" checksum="5D35F0C81BE1CBEA" modified="2014-09-03" version="1">MAAVALHGYKVKGVNNVVVRLYPQVLGIHKVHEHNLCNALRDFGLMLKSECVKRIKRSSCLYSRDELLQYNHDFLKFAHTMRSSELCMIAHGYSILELDDRDWWDKFSAIAARNSYDMDGKEMAGLMYSLSRVYPYKHPLISQLIEESTPWIQHANPGTLSLLVKVISNLKIGGNYLHRINKRAIEIISELNIVDVIFFITSNTDAKVRDLELYRALCTRSIELYDDMELHHVRALAASLSIGGYKSSLFFNVLSLRLVDICRTKKLKDGDVISLFLAYTSQKFLSQNDLCIDVQVYKRFLQERHGYISKDKFEFPIPELGPVFSKALSDNIHRITANGMPIVLRAISILKIPVDRELYSRVLQETAQYIRDGKYDGLKLSNLVVTIAKRPGRHDVFWNAVHDTLSKPDADFNADIVAKMTATLGAVTDDAPRRLVYKDLINLSLMCCKDMTVKSIFALTRVYAANMELEALCSEPYVNAVVALMQRVPVSDVFHLLKLYPFRVLPPGNRNVVHLLEAAKDALNKSHERSPGFTALRVMLEDFVYKQDAEDTTLKTPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D459</accession>
    <name>A0A061D459_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767544.1">
        <property type="nucleotide sequence ID" value="XM_012912090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D459"/>
    <dbReference type="GeneID" id="24563899"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205160"/>
    <dbReference type="OMA" id="HQLRYKG"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010297">
        <property type="entry name" value="DUF900_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36513">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36513:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05990">
        <property type="entry name" value="DUF900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1155" mass="132216" checksum="D5511055715FD95E" modified="2014-09-03" version="1">MEQYVEDSRATNASESEVPGEASLGGNETLEQDAQVPIITCDDVADAPSARSIDQQKKRRSVRQLKDLMIQETILFMDYRRLRRRFNGIRQPLSYKKVLFISLFCVCLVLVPFGYFKQEEGKYVMGLEIKHGIMPYTSSSLFVLASFLLARIQLSIPFKWPIAISYLFMFATLIIMIVSKHVINLGDFVWLSLLVYTILQIAIIVGTRIVIWLGPLLALNGLFFPCTEHFHLFERMRRGGNLNITISRYNDYSVMCGSNGCGLCTCIYRVSYRWLRWLLKKIFATDGITKGDTPFSHQMRYRGEVDENEQPHGYGEWLEDDGYGERLQGYWWHGYPIGPFSSQEIGSGSIFVNTRVAFITDTRRPNGKVRYGVSSTECSISGNFFREFPLTYFFNPLYNDKNNHNPGGLYKHCKFFNVLNGRFADIQGASFKWCVRMLRSQFFLNMPTNTSTITVYIDKLSNSLRLDGYKRTCDTSEVKTCDEITIKLTANRGMGMLSRLNQQYGNNSTHRMYSNLEANELSNNKNCSDDATEDDQINREHTPGGYLKMRANRGLLNVSHPAHGKDAISHLFLDEDDWEDQVNATAPQIMVKGWAPIRTFGKKGCIADQAVVYIHGYNVSLHEACSQMAHLVSFSKLPPYVLPFVFNWDGQHWGPLGAIAYHKAKRITQHPGLEESFCELLSELLGMGIKNVHIIVHSCGARVFFKVFRAAIQKGLILQVLGTDNQATPSNSYATDKATSHCKSVPIRMDTLMLLNPDYPMERFRDHDYFLVRSYCDHIVMYVDTRDHCLTMAELFNGEISLGMSVFAMCTTPEVLDEIVPELEASGLCLPMQNNQNVTELPFVSSYTMYKGKVALSRRNPGEGSLSIDMTPGQGSGALKRETINNSIISPSQNYVVGNSSKISDDMQPYRLARLSEDLGVESRHLWLDMDVIDTTMIDTNVDFLKHSLYQMKREIMDDIREVILMKIRADQRQTRLDRRRGNSLATAPAPLSKNVEFPTLVKPRWIIEPPNYTRTPLWRQFFEAQFSSRNFLIFGCTWTAMASIAFFMWHSRIYDTPPRERLDRYWLNSPKCRILSAVYNPGKRPAAVMSLMTYESRYFDKGHDHPFNVNEIKDYLFKLKESYLIENHPGIQYPHVFRQHANVKTPPVLVANLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4D1</accession>
    <name>A0A061D4D1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767624.1">
        <property type="nucleotide sequence ID" value="XM_012912170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4D1"/>
    <dbReference type="GeneID" id="24563979"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205960"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="384" mass="41902" checksum="701252C8C71CD951" modified="2014-09-03" version="1">MLILNALLDISPFKGSDPKSAPTLIGEVKQTTRAKRIFSELMKLKSDIDTKRSIFKTSNKEVTAPNYKGENRYLGIKGLLNSMAQKFERLNEHLTSDTADDSNELKKKLVQFDFGDNDDILDNLRLNDVKEFQKLFYNINSPIFNLRKLFRDYEDYQSDANVQPKTHPFAVFITESADGEELKPLDKANGNITFLSHPGDSQSISIVYNDNGNTSERQSSASTIDSHDAAGKDKVIENSNDGRDSPTEMGVGGSSEKVITEPSESASREDESLDNVRETKEQQISTGEVSGEDNRVSVVQAHGGGDAIRSPDLPVADPTLARPSSASEALAPSSRVQPSNSQEMPPTPSGSLRTGSAEKSLQKASSAFDSFVTMLLVVSAAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4H4</accession>
    <name>A0A061D4H4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0201090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767138.1">
        <property type="nucleotide sequence ID" value="XM_012911684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4H4"/>
    <dbReference type="STRING" id="5866.A0A061D4H4"/>
    <dbReference type="GeneID" id="24563493"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201090"/>
    <dbReference type="OMA" id="ECKYSHE"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="27962" checksum="A890CB0E80887BC6" modified="2014-09-03" version="1">MTCNDGYPDSTSKSPTLKKKRRRSEEAAARHRQRYLEILKRRAESQSHRVESQAWTPRQSSSHLPSSDTKRPLCKFYYRTGSCVHGTSCSFSHDCVPLTSKDLKLCRYYIQGPTKCKYSASACKYSHDPSLFLCRNSVLHGSCSNESHCNFKHLDAETISALDDAEKLKFCYNNKRFLKDLLIRHIEGANASDPPDSPREESSSANHGAIPHKLLALSPSYLADLPWYLRFLHTLLVRDHELGENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4T7</accession>
    <name>A0A061D4T7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767769.1">
        <property type="nucleotide sequence ID" value="XM_012912315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4T7"/>
    <dbReference type="GeneID" id="24564124"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207380"/>
    <dbReference type="OrthoDB" id="366428at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="307" mass="32778" checksum="1922CCC330476AB4" modified="2014-09-03" version="1">MAVFRLLEAVSGGKGGGSGSAVAAGGRSQDDGPGVRHPVAASTDNPDGTIGADQRDTSISMEQDVTPSDGLDEVDVIREFYLSRLGELPARRSAGGSHPRRNRVAAGTGSPRTPRNGESDSHVSASDGVSVGVQAGASDGIHLSNDHAPGINQAFVESVDALNGKLEQYYRMVNENGSCPSEVLGINEPSGRLADAIKALDRRDYLCRQILAVQHCQLLAYYGGGMYGANSQPETPASADPYRPDSVSRGFNIANQQSTDSREAAVSGEATPCKRMVRRDRTQSEEIARLRRMVELYKNELSRLYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D542</accession>
    <name>A0A061D542_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766275.1">
        <property type="nucleotide sequence ID" value="XM_012910821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D542"/>
    <dbReference type="GeneID" id="24562630"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103985"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103985"/>
    <dbReference type="OMA" id="DKQLECK"/>
    <dbReference type="OrthoDB" id="354322at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="97" mass="11020" checksum="DB47CD784F7B790C" modified="2014-09-03" version="1">MLGRITNIKLFRRLQRFDKRSGFFTIGGPTLLVLFTVLVAGTVIVDKQLECKFARASSLSKRELTLREEHDEMLKMLSAVTPTDQLDNSVPLPKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D555</accession>
    <name>A0A061D555_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0104130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766290.1">
        <property type="nucleotide sequence ID" value="XM_012910836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D555"/>
    <dbReference type="STRING" id="5866.A0A061D555"/>
    <dbReference type="GeneID" id="24562645"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104130"/>
    <dbReference type="OMA" id="IPETAGF"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009479">
        <property type="entry name" value="Herpes_U55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF1">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06501">
        <property type="entry name" value="Herpes_U55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="7">
        <location>
            <begin position="140"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="730" mass="80685" checksum="C0F9CF3A3AD941C9" modified="2014-09-03" version="1">MMREETDRGSAIASSGDEMSRGVSIGRSDRTDHSDHRVKVIQYEDEDKDVCVRYYDTDGKDEETAGYNYHDFSHHTWYDYTRTREPVPAPIEKRECEDIFMCLPFYHGVLRSLVKCSTGITSGWGFTANPKENFGYYLTEIINGLLCGMTMLPEIISFSFLAGIPPHVALHGTWIVCICAAVFGGSPGIMTGLSGALAAVAGKYALSMESPTTEQIEVHLWSMLLAVFLAGVILVCCSFFHLASISQFLSTSVIIGYSNGLAIVIARAQLHGFQDPKTHHYIAGVELVLAIVYCVIAFVLMQFTNKIPKVGQYLPPALLAVFVVVFIDLAIVKQVAPDIKVTTIGDVAFLTSETALPVMSWTHWSAIRKVNFNMTFVCKVFVLAGSIIMEALMVNDIIKTLSGNDPNSNQQMFGLGIGNMLSAFMGSSGGSSMVGISVMNLKAGSRGKESSIAAALFIFVMLGGGFPLLNYIPIPSLCGIMFSVSCHCFKWFSLPMCIVTFMPQAIRNMHPKLKMKITRSDAIIIVAVTIMCNLVIIPLAIIVGVVLAAFAYVWESKSRFKVEIYMDNETNIKYYEIEGNIFYASKRMLTRVFTPEDDPETTVIVLLASTTLFDYTAIETLNSLKSEYASYNKMLLIKGLSHGCIKKVAKMNHLCRHMEHDLVGIETPNLPTLYSRFTNLRNKLQMIAVRQCGTDQQESEETTERTDGNKSAGEANEVTNNEKARSQVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D571</accession>
    <name>A0A061D571_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0208670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767899.1">
        <property type="nucleotide sequence ID" value="XM_012912445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D571"/>
    <dbReference type="STRING" id="5866.A0A061D571"/>
    <dbReference type="GeneID" id="24564254"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208670"/>
    <dbReference type="OMA" id="FIATEHE"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061513">
        <property type="term" value="F:glucose 6-phosphate:phosphate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051337">
        <property type="entry name" value="OPA_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826:SF3">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="157"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="624" mass="68241" checksum="00C565C391C9B0A5" modified="2014-09-03" version="1">MPAASAGKHDLSVHNVADVEVALGSASGVGDDELASSRFGYPAPESDDPTRSLADSARALAARAELPADALSSAREDVYDSSNITSPNITDGEYIDISLGSPEQPGRSPGDIEAGPSELEYTPSNASVLGEHHINEDDQPGPARPGRGYDLKRVLFAFTFCWLSTFVGQVLRMPLSSAKVNLQRNLGLTTLDLTHLDTAFSVCHVFGQMSSPALSSKTNNVALIAMYQFVMGFAMTLLFAPNSMGCFMVVYAFAGFVSGPVWAVLFSHLSEWLPKEYSFPLITVWFTGSDLGAIAGALICIYAHESWGWRSPYVVSGLLNMLVAVLMFCLYDNSKEPTSDGRIVDPRAIVRNNFRQLGRYARRIRRRRNCVESFIATEHEPPAPAPDSRREFILSGLSNIQQEVKETAAGSVSFSSLSFFMRSRASGLYSKVHRVSVDYVSALFRVSYIGRIAVASFILKLVKNCFSSWVNFYVSTMFAFTVAQGNYVSLTFSVGNCVGNMLVAFVCHVFWKGRPLTACTYFCGATAVAVLVFSLMNFSWPLLSYFFCFTTGVATAATEAILMARGIKSLCDRSELNQQESLVVYGFLLAISTVRLGHLVRYVRDCTDDRNGTVAEAITHRIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5E0</accession>
    <name>A0A061D5E0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767959.1">
        <property type="nucleotide sequence ID" value="XM_012912505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5E0"/>
    <dbReference type="GeneID" id="24564314"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209260"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7570" checksum="DA7EC008301D71B7" modified="2014-09-03" version="1">MSEGHRSQPSGHNQRIAEKNTTATERSRPTTNLVRWMLRHGRANVPKASKGAKIDSSTDDAKGNTPSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5E6</accession>
    <name>A0A061D5E6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U5 snRNP-specific 40 kDa protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0204150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767443.1">
        <property type="nucleotide sequence ID" value="XM_012911989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5E6"/>
    <dbReference type="STRING" id="5866.A0A061D5E6"/>
    <dbReference type="GeneID" id="24563798"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204150"/>
    <dbReference type="OMA" id="IWDIRPY"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="315" mass="34667" checksum="A0567CBBC1CB83A1" modified="2014-09-03" version="1">MGDVVERRTSGLKAPVLLLTGHEGEVYCVEFSSDGQLLASGGKDKNVFLFEVYGECRNIGVLSGHKNAILELHWGANGENLYCCSADHCASLWDVEYQRRLIKYVGHTGIVNSCYPARSVVGGMLVTGADDGTVKVWDHRSKRPVKSLEHDFQILSVCCEPSGERFFCGSLDNTIRVYDNRSDKELFKLEGCTDSVTSLDLNHDGTLLLSNSMDSRLVVWDVQPFCTESSRVKTALFGPTHSAEKNLIRARWGNGTIISSGSADRFVYILDTKDNKLLYQLPGHLGSVNEVVLHPTEPIVASASSDKCVYLGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Z0</accession>
    <name>A0A061D5Z0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase ATR</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0211250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768164.1">
        <property type="nucleotide sequence ID" value="XM_012912710.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D5Z0"/>
    <dbReference type="GeneID" id="24564519"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211250"/>
    <dbReference type="OMA" id="PYITREA"/>
    <dbReference type="OrthoDB" id="364657at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="2996"/>
            <end position="3312"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="3333"/>
            <end position="3365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="854"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1406"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2039"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1406"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2053"/>
            <end position="2067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR95978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="3365" mass="372675" checksum="D59A8AAE53E7C143" modified="2014-09-03" version="1">MKSLQLVGVGIEMKNPTVSVNDNTLRILAILISEFSYNNRMPHSVSVDGKRWDVFRDHTLMSNAAVSQTCYPLQALSHTIAAYLLDHSLRPLTAVVSDPQTMAHCIALWHAYIYLRMGYCDFACRKHFVRRVLGDNGAGGHNSNALLELLETPAQTWHGPVMYTESEYVAMLRAMRLLQEIVVHLLTELSEEDARPRPQLRNAGSDTVVGESAESDNAKWLRITARTLFVWHIYYYRLKIQRVGTHAHDVDYYTSFFKMATVTLHRFRSQTPAETADVLTSVTVLSLSVLSRSRGLDSIYQVVPHVLLRPTTAVVSSASPKNQAPGSGSDTSPHQDALLRVDAFAYTNMKAMVESYIGWTNRPYDIMKSVYTELQEAGHKFTSLFEVAQTPIGALLKAYGRYARLRTLEFGTPERLTYYSSEREGDSDSAPTTPRKAGAVKYGFTKCFEVSVDDETAVAIVCLGSEAAIRLLLTHDCMNTKDTALAFVILNTLILLLLQLQQRLVAGSGAGVGTGRGSTALVLLETYLHLQTVGISHDMRASIRYFLMSIFTVGDAVVEVLICMHVGSKSPPPPPPPLSTEHGSIEGYTECPGSRQEWLVVMACLRCVTSSPIKDVLYVINTLTLLADLNANGGVTMSSASTRSGSEEALFSNTNSKESQLTASTAAKVDDDGSGVTLSSGGSGTGVPNVSVEHASVMEKLLIHTLTRYFASVAVNAKRLQVSTSDWARLNASFVDGVFGATFKFLGAANVADVTYDVVNVVPFMLNLWHILRPHPPSDNLDLVEYCMALQSLNRRRHSVAHTIPLLSDSNRLMNLMRRVVGPPTAAEAGDADIAGEPDDATATLTMAFTDRCSEPAAKKRRKNSTSVASEPSSKTNRQSSPYSPYPEPVNLNWSGDLATSKDTSSASVERDEDAAVVPYSRYIELFAARLPRFCFHCKRALQSDGMRRGLYHVTCSHCGRPSPLLCEGHVDSNNSSYGVYLSSAEPFTATIKTEGGLLAPDLSRNSEGSVDLEWETIASLLVRVTRKMAIECSTAEAMNAVSTGISDALAFYISSAPVACHSVLKVASALSAVGTCFVLFMMDKAHAYRKLGKLPVDGFYTDFFRTRFVDNMTIMSDASADVDHLQVQYFCDLLAMSTASSSSRPESETACMDFWHSAPSLVANIGPTSLSQIVTQLLQEIVDGELKAALPHMSIEETSDATDCLFTGYMADELEDSDGKYDFAVAWTALSQVANVMCIPLLRLFVSGLSLTPVRLALTVRSRLTPVQPLARALLSSVMSARVLDRLEDIHEGPVQGVLCTDVTLNFTLDNCDYRLFQIMQLLNEGGQPRENAEQLRRLDKYRFYALVRLLWYVTNPHVVLRMKYARGTKTLLSAQTDYVAAPFSVCLEITREYKRQLVKQLRAKSTVTSTQATDTSMRQDSIGKAGAAVPPADGKPAQPPNDTSPHLRLELAALDVQNMEALQNTAQGDTQHPDLPHQPDGMDLYGALDSGRRYSEGGAMTEYMRENFVRILEYFVAVWLNRGQHSLNFALKNKRVFYPEIYGYSGRQEIAAAHVARTYNCIAILVSIYNGDIDAFCDRMIEVLTIYQPDVYNGRALLVCWDAVARKLSCDLLGPYAPGIAYYMARIAMIGSDGSAEAPPAGCTASSDADDTAPTPEVLPSSDAISAIKMRLSGVEDGERYCAYIDCVVDCVSRPHELERIEAKLEMLACMVYSDSEIKVPYITREAAAITANQLLELNPFIFNMERAKKAASKLAIAALHTIAEHSDDFAKNPTALDSACCSILGYVPCDLNEFRTPRQPFAAGMQCFLSDPSELAAQLLKDYLIPNMHLQVALYCIQEILKLLGLYKGGVRSQAELEEMGERWNRTFEPLTRRAIEPYRATSFLRNRAIEGVIETRLDVNTVLDIKSFVWWLLKMLPDSCPTLPLFRACDLAMIKIPSVLTYLLPYIVDSCVQFLDDEQCASIGKRMASLLCNILKRDSATFGINWQPPYEVLSRSVMALDSTDQYTSCQAIFNLLDGIKVLTDRYRKELAVLRGGSSSGHSKRRKSSPTTEDQSTYNRTTVGSADDSCGSLCGIGSERDASETVRILVTKMKRLESILHAVPELLVAHAAISCGSYARGVMIIEKKLTYEPLSYNFGNPGQALSNQAIHAKVHNIGLNPQAIISLLCRGYLGLGDFDSLVCISSIVLHDDSIRSEMKSVRNDPASAANCRTPHPSDSPSVTANAAVVDATAPGSHAAKLVESRRGSITKRQKDVCRAFSYECRGEYREACDVYNRLLKFSQDTRLWTSWYRIIQMTGPSVFIQLPKLPELEESADSLIAESLTACWKLSLWDELDELLEAKRTHETELLEIKAEELSSIEVLLLDRSCDRKDARGSQLTQCTADDRRESDVFWESLLMRDPIDVWFMEQTANAMSLLHKRDYVESERTIQEGFKHLIRPLGLAIRESSLVALKYLEKIAILNSLRLSSRLSAGKYAVDEVSFARELLSLNQGAAEHSVRNVINILGAAKVALELGDKCDAAAELLVSLNRTCRLNKVDMHIPGSMSLDDEALSGRGDVVLEHALTLHHKGHVDDAISSLKHLARNDFDGFYNLVKMYSQSNLLIPKRAISYMKEILDAAPLSFKANLLYAEYLDRLLDHRLRNAHNFRLVLDDSSICTRRSTVHSSVENTYIITGVEGIPGVFTFVQLVSATVNAYLQALAFVGPKRHADDTAPGGVSQGGASGEKESSRAQCLNKASCGDVCKCHPNPESSDAVNKEDAGNAGTNAFKGADHKKAAGPVQDSGEHMDIVDILTKVIAIMCFYCTPNTTQFLSTVTFESEACQIFANAIMEKFFVHTDAVPQYYWYAVISQLMSRCHHKFLGGAIFQTLVARLIARYPKMALWSTLYFAHSVNPRMRQIHANIERKARELVPESALVVEYHHSIFKELSKVAMDTTVSINDKSALRFQSMWRVLNSAGCRENAIIPTIENLSFDHIIHYDIMESKSRMCGLDESMQVLRSKQKPKKIGFYTASGQVVHFLVKNEVKGDLRKDKRMMEVTQYVAMRLRKHYSGMPLQCYSVVSLTEVAGIIEWVPNMATMRALVTDEFRRVTGASDREHKGDISKYAASITAKNYTDSLMLFKRLCQRRPPVLHRAYYKVFKRDPAAWFCARKEFIHTCAVWSILGYIVGLGDRHAENILLNLITGQVMHVDFDCLFGKGWLLAVPELVPFRMTQNVVCNLGVCGTATDGPFYSEALKFLQMLQQDRQKITAILMSFVFDPLIEWHRGEATPNPDSDSQKVLQCIESKLRGALNVVLPSVEISSSLSARGNAEDAGDPQSLKSFENVAEIMEPRQQLQQLIQVATSQTHLSKMFVGWAPWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D687</accession>
    <name>A0A061D687_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0301110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768392.1">
        <property type="nucleotide sequence ID" value="XM_012912938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D687"/>
    <dbReference type="STRING" id="5866.A0A061D687"/>
    <dbReference type="GeneID" id="24564747"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301110"/>
    <dbReference type="OMA" id="QNNDKIC"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="129" mass="14033" checksum="C7FDC3111F4ED171" modified="2014-09-03" version="1">MIGVNHVCEIFVEFAGGLSAFTVDKRRRLKIEIQTESVTVSQLVAYLRKAAFAAKRDLFAYPPKLEAIRCSEVEVRGDLPGVFNMGETSDVIPGVIVLIDDTDLELLGGSGHKLKGKRDVSFISSLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6K9</accession>
    <name>A0A061D6K9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch repair enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0208110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767843.1">
        <property type="nucleotide sequence ID" value="XM_012912389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6K9"/>
    <dbReference type="STRING" id="5866.A0A061D6K9"/>
    <dbReference type="GeneID" id="24564198"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208110"/>
    <dbReference type="OMA" id="LVRFPQK"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="777" mass="87784" checksum="0C0D7C05C6539541" modified="2014-09-03" version="1">MEENTSAEIFDGDASYKHTVILAIVCKQERSAVKHLGVAICNFLNSSLQVTEISDNEFFTLLESVILQVGPTVCTLSTTKDAIDVKRLKHILSLCNVQCMSHTFSTSKDATSAVEEMKIKSNLEYLLVEEDHVRNHAKLLSMQLAMKALLGIFDTFDIAKQPAYKHKFHLDEYKVEKYMSMDRAAFASLSILPSNSNYMSKTSIGTRRLRMWVSQPLTDANEIRKRHDCVEAFKANLYKTIQAECLRKVPDLDAIVMKLRAIDSGSDLDGRIKSTITFENLVRLYDCVIAVNRMVQFVLVPYDGIHSETIKHMFTEPLLNISSLFETYLRLVEKTVDLKEAEKRNYIINRNFDNKLVQIGGKVDKIRADMEALRESFEDEIFYRSNKGRKGNNLKLVECSNMGYLFRVSKKDQALLQESERLKGSIEKVRLNKNEFLFTTPHLRQLCAKFNSAHKDYENEQTALVNKAFKVAATYWILVERFADVIATMDILAGFAEVAATLNYVRPVIDLENVEINLVAARHPLVECGLSTRGFVPNDLVMRRDTSRVHITTGPNMGGKSTYIRQVGVIAVMNQIGSFVPCTKAKLPIFKHVLCRVGASDIQLRGVSTFLAEMVEAAAILKTADEHSLAIIDELGRGTSTYDGFGLAWAIIVDLIQRSKCFCLCATHFHEMGDLVKDHEGVKNKFVNAKYLENAKQMVFLYEIKDGICTDSYAINVAEIAMFPQDVIANAQKKLNELEDVNKSEDWETLQPLLSSKSFDDFKSKLQDLCNSIKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Y1</accession>
    <name>A0A061D6Y1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0303650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768647.1">
        <property type="nucleotide sequence ID" value="XM_012913193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565002"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303650"/>
    <dbReference type="OrthoDB" id="367204at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2226"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="933"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2288" mass="258891" checksum="757A9C4CFFBFD720" modified="2014-09-03" version="1">MAPQFKKLTDCPENLREAIDWLIQVRHGGNDNKGLEKLGKALKEFIADAIWNTQNSLDKKRDEIDKIYDVAEKLSKIAKLDDQEMSFINLQKDLEPFLENLQINSKDPDKSILTRLCTGLETFLGFNKDSKGYTGQGIVYSDMDRLCDAVMAFLHGVLESVKDDDAVTTYDRYVKIESKDGLDTVLDFIVRQIGKGREGLLESVMRVRQWLEGYERRVGERTGNVRDILNSLRSRINDRIDDITEQRQDSLKDQLNYWQTVTQDFLGMSETAKNFLRDLDQGFQKQLDTSANAVIEAIKVLETSTNNKGFTMAVTAVQNAFDTLPGEVDKFISDNIKSTIMEHKAKVELLKKEVKEKMDASRDTFMINGIKMAKVDLMKAVITFSKNAMNMGGLNNSVVKQVIETLEKRLKDDAEKVNDANSLNALKSNPVEMQIVNIITSLNGKMATDSTNGLSSLMEKIVKPEDVFRDNHDAALLQLVNNAKNDMQKALECADEHAKNRGGLNNNAVARVISAIQNKLDQEAERIETLDKLKELKRKFMDGEQITQITNALSKDSTASHVKSGLQQLTTSIEAPEELFRKAHQDKLAGLAQNAEDDLEKLISKAQECIKTHGGVNNRKFLKVIINIEGKLGSLESSNGIIDTFQKLKALKNPYMDGQIRSITTTLNDNDAASNVKSSLEGPKMSIKAPDKIFNDTHKTNLDRLAGKAQEDLQNAIDNAIKYVESSQGSLQRNIVGAFEGVLKSFKQGQKTVTELKNTIEKEFKRLTNISTTLTISHKGNVQSKLNQLDENKILAVKGILKPQTSEQVSEDQLNSWFKSANSYLLTYVLGEANDEIIKADHEYQTAVKAQLMQIKSKIKNFEQKAETNNLGDITSDLESNFLYIQSAITNHSVYETDKSGRQEYFNHLTILITDTVSILKTAYQKAYSTTAKTYLSGAIKEIKERVENAEEQYKDTVIRLIQKIEGTVSEIKNRAGKDKLEELSTSLKHFEDIQSAITTKSVFSEDIIERQQFFENLKSQINNTVATLHQAYKNAYQSAAKSYLSGAIMTIKYKVEAAEGTYKAAIRGCIEQVRNKITTLQDADFKQNSDRARLTAKLTSDFGQLEAEVAKNSAFDEDFTSRKQCFTQLQTLIKNTVETLSSFYEKAYQSAAKTYLSNAIKNIKDEVQKAEVQYARACKANSVDIKNMIMQLRDESTKKELERFVTDLTQPFDNWIYAIRKNSAFQMDYEGRKQCFEKLKDLIRNTVNTIILAATTFDTCASRAVIYLTESFKNAETGIDKLGVGIMDKVKAAFDKVITEVYAMYSEDKIALLKSLKNCVEEQKREVDRIIGIELKKGIKGFLHLLKMWIDKKSGDLKKAQDLKSLADLFEHLNKHLHRYVKFQHDGLEVGDDSDDDDDDSLSPTPAVRQVTPSISGGGYRARPAVQSVSSKDPNAPQPAGRAGYLGKVRTPSTGQQFLSPQLTKDPISDCFDRIDHHTRGLFGTLSAGYFSKSFASKREEFVQFLDSIRPFKSGEHCDTLLYILMSCLQSFLKELGKAYISTYCGAAYVFEWELDGEKCAKAFLTILEILYHDLDGLRNKCKDAKLYRANKLCLKEDDNRRANHLGIWFDHRGFTVSDNKDKQDGELDTNKTGENIIGMIAGTSVTTAAKNIYKGQDDTTGALKSLHEYLEDYYRVCHHRLIPDARAPTTIYEMLHWLGGLWYNPVAEPLRDSLRKLLEDVERENKVETDKLQVALPYRRSVSMSRTLTRNELIYVFNNSTIRSNLLLIAILGHGQEDGRYACDFLTNPDDLLYPSNPDKCLDLLVEVSLRVNHQIRFLFKQCHNGPECGGWRDCLYGKGIGGSRWQCNKLQCPNQECEQKCRQHYSCGVKSPLQLFLEDGLLGFLPHPFEKPDCKITCSLQNHNGIPCKTPMGFRDLSIRASHQQKGERIKKVLDWFCGTENESLNLLCSYFLLLLRRPPQTLCDMFAFYYNFLDHYDDDRSTQKEHRRLAFNNAVTKANLGRPFGALNPSTILCTSKHVPSDGKPTHEKGDLFGVLSCNPEDSPTMPCGRYLQSIGDDIRLLYYGEHASVYLSWIIYQAETFYNLLRDLCDKCCKKCTSPKSICYGTRCTRDCQVKTVYESNKSDDHKADLKALDGKKHNDECNSIVNCSNTHSILYTYGFTFGSPFDLSGGNNKMEKKRTCKDFCRALDNVLNKEKDVEAPLAKLVFDIIPEYLWVIREPFFYTTVALWLLSLFYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVGRLSKISYLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D753</accession>
    <name>A0A061D753_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768732.1">
        <property type="nucleotide sequence ID" value="XM_012913278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D753"/>
    <dbReference type="STRING" id="5866.A0A061D753"/>
    <dbReference type="GeneID" id="24565087"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304490"/>
    <dbReference type="OMA" id="CCRLGAR"/>
    <dbReference type="OrthoDB" id="364843at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="77658" checksum="20D739EF44CBD3FA" modified="2014-09-03" version="1">MPDGPYYNQDFEEAEFNAAIDEMAEEDESTDEMDEIERQILEERREKELYDRLNRMVRRSAELELPKTRVATQTMYPPGRPDDEAANREPNEMLLKECLANRNLAGVVNESSKNQLEDDTIILTAGSDSKEPLESRLERQKGSMSQLTDEEIERMRAEVPPLESQFDEYAPIKLPANANSTSELISGIIQMPNVKDKKFLQESIKIKDYSEESAPPIDEDEIWLRGVNEERAKRGEPELRCAEGEKLSDNPEYVRERRALELREVRDIRRIAHEARKNREALKHTFYRKLPRNNMGFAELKPSDIGQLSFQEVKEELRARGYCTSGGEKLARLRLEYALTEPDEWRYRKIVTQPLDETNENLPQRARERIADLKQKVKFINESGWGGDMLTTISRLRAKHDLIKFYDDPVGYLGLDMCDPSLQVSPEEAEELRNAPVVHDTEFIKALQDPINRLPDIIPRTFNLQHDVERPYPKYAATHKAELEDMKREYLSFKGGIHEETLLDISQRYEISLDFLGDACCRLGARPPVPLDMPLRSIISYSAIWDLTEFLNIADTLEVEAFYSILNITDVAAELGKTVKEVEEACKSLNIKLPFGAETKLNLHCLLVVEKLLKTPDLDVDLLAQDPSYRNRFRDPNDNRPCFPNSMQDDIHREAIEQGALFEQPEFYGDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7B2</accession>
    <name>A0A061D7B2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0303320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768614.1">
        <property type="nucleotide sequence ID" value="XM_012913160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7B2"/>
    <dbReference type="STRING" id="5866.A0A061D7B2"/>
    <dbReference type="GeneID" id="24564969"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303320"/>
    <dbReference type="OMA" id="AYVVKHL"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10299" checksum="031384AF72862548" modified="2014-09-03" version="1">MVPRSGKRQESFATAESDVSRDDDDGGIKEEGMDIIFEISRILNTGLDRETVSILVGLCEKGVDPTVLAYVVKHLKEARKDFLSKLVSHKPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7E8</accession>
    <name>A0A061D7E8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768822.1">
        <property type="nucleotide sequence ID" value="XM_012913368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7E8"/>
    <dbReference type="GeneID" id="24565177"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305390"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="133" mass="15431" checksum="C66C1EDFF4674C7F" modified="2014-09-03" version="1">MFLQTSNDNGSEMMEDHISGSKGAIEIDLERGLQGMVDKRTIRQSYRDWEFKRSVSEQGIAARYGGKLGGDWWPVEVVEVDIKRPHWLTPFNLPIIIKCVVDIMHELFTDCLWMHNLETFYNTSLDKRLAINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J9</accession>
    <name>A0A061D7J9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0305800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768862.1">
        <property type="nucleotide sequence ID" value="XM_012913408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7J9"/>
    <dbReference type="GeneID" id="24565217"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305800"/>
    <dbReference type="OMA" id="NINANVM"/>
    <dbReference type="OrthoDB" id="359759at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="304"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="404" mass="45548" checksum="F2E9E595900546CE" modified="2014-09-03" version="1">MDRSYDFKRRATHWQMMMREATSDSQAASPEHHTVDRFSVISADVFAQLRTLREIISPYAVLAHTGHGSKESIGGHVKIPILANTMGYIHAKRALFEQTDIKDIVHDTRHAGDLIKQMTTSIEEELKRMRRGTISRQLQEHRLGVIACLQHSLKAVESAVEEYERYRLKVETNVTASLRLMTENQVKEYRMRKGYGLDGNAEKQIIAQDYLKLFMEDSNRSDTLAKGDGSSVAQSGDSIAASTFSSPVLGPSVQPGTTMPVLRRQQSVQMPHMPAYMDYVDAPQEQNTQLLQMQHKNLVAQVQQSVQANELNTINGVQQRLAEISSMFEQFSGTLAVQLDMFESINANVLESLSNIETTETSLKKAETEGMPYYQLMMCYAFIGSALFLLLVDYLKSSRGSYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7P8</accession>
    <name>A0A061D7P8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767110.1">
        <property type="nucleotide sequence ID" value="XM_012911656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7P8"/>
    <dbReference type="GeneID" id="24563465"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200810"/>
    <dbReference type="OMA" id="FRYMEDS"/>
    <dbReference type="OrthoDB" id="361577at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595869" evidence="1">
        <location>
            <begin position="19"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="500" mass="57656" checksum="ABF241B36FB240CF" modified="2014-09-03" version="1">MRCSTALCLAAIAYSSRCCGHAAAAARGSKHAFLCGAAAQTTRQLLLRNSSQEYDIMADPLDSAPQIEYYTAKYPPYPYYDAPRNLFFDASGLKEANAEGDLEELCVASETQKSYMKNAEMRREGEEAEPLDDAPIASNGYFSQFDRMIGKDYRDYIYVAGTQHHGERMRTDIAEYDAVRPGIAPWPSYEQLKEDKLAVNTSLFNGFDTTNRLERHLVGKPMLRNDITTLGEARTEQRRWLRRSYADEWSLTYEEFAAMPLDMREAYYANRYQLCDDDEKFAMVLNYRRALGRAGDKMHPAEFRYMEDSYTYTPKDSPIAGDLLNWDDPLDAPWRLRVEECIRDCVTYSWPPERIRFHTCFEVYDVTWLAGVVKVVIEQTRDEGDFISPNELKLMLLKLEKRLKQLDEEEHTQSIATHSLMLVARLDPKRMAPEELKTLICRRDWNSHIGQEVIVTFTDKEASQIRGIMRGSHSVLALELDVEGRRHTLPLNFIREITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D827</accession>
    <name>A0A061D827_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768997.1">
        <property type="nucleotide sequence ID" value="XM_012913543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D827"/>
    <dbReference type="GeneID" id="24565352"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307150"/>
    <dbReference type="OMA" id="ERICKND"/>
    <dbReference type="OrthoDB" id="364598at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="686"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="774" mass="88088" checksum="F634724F4757F717" modified="2014-09-03" version="1">MEGSSEYCSPVPCCFIATKHPMNDTGSKMECASSYQGLPSQPEGYPCLRFHAMRLPTWAMARAKDGVATEQHSLSGGEASENGTISEMRKQPMASKPITRKTRSRRKLGKPKTVADIIKRRLIPQPPSLRETDRLIARKPWKRMGIPSIIKQERQKIEETDAFLDDYFHSYLIKKGTDAGLRCGVKTVDEKLFQNSQSSSQRSSSNDDMTPGTTYKYDADELLQIWNTKGGHFYTSIPKTVAMLQIVRRIAVDSKADLEMINRIRDHVCFKRLVGSVVRHMKYLTRIELPSHLKNYPKLMKMVPKFNNEQMVTIFTVLAYFRFSNEKVLDAMLQYSKPYKEFTPEEMRSVIISCIKMGADASQIVGDYVDKLKAEIMQSEQPNGNAQQELDIYLDVLRICSKTDHMDNELFKHIARFVKQQENMPVGTAIAAACLFAEVHHIDEELYQHLYTVMTNNIDSIRGKNVVNKLVTGMAMCHSRPPKKLVDHLANSVLQEIKSYSLVKLTATLRNLALMDSYNDALCHKVFNLELFTNPPSVKVLQQINLKLNQKKTVYAAYLHPTATSTLNVVFGNAYQAYLGYRLLGKTQNKFELPKEAVSRLKVRLSVVETCMKQAIYTASAKNWTFGSSSFHIQVRDLLKEAFGIESEVEHITSDGLLVDIAILPTSLAQFTEQVGAQDFLKDKRCAIEVHGPFHYLQKSTDVFPPPMNNTTTFKERLLRARGWDVAHLHYWSLVPWMKRDHKIRVLARLLPQWVKNICNIADVKTTPSQMAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D852</accession>
    <name>A0A061D852_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766086.1">
        <property type="nucleotide sequence ID" value="XM_012910632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D852"/>
    <dbReference type="STRING" id="5866.A0A061D852"/>
    <dbReference type="GeneID" id="24562441"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102290"/>
    <dbReference type="OMA" id="FWNWNRE"/>
    <dbReference type="OrthoDB" id="364553at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="442" mass="50029" checksum="A4094433F6ECA07A" modified="2014-09-03" version="1">MSAPGQDAAPQVSRLLAKAPLYFTMLREQLFLREEHQLDWRLSDALSRCDSMRDPSLSGLLNADSEEEEEPAAAGPGDKREPPMLWRDLDWKPFSGFYYPIRPGDYSPLSPDGEMLERSGKIGVDFWRWHRERAPLGYTPPLCTCKRTADTVAMLRRCVMRQKDGRERRVCDNDVCRGLLYIPHSLLEIPLNRVISNGSEFVRHVAVPNDTDVYCGNMKHTLVICTTSAEHEAECLEAIRQSDVPDSLVYHVNANGFIPYFKHHVFIGSVAPLMTVEPIDSDVSDSEENRGFGETFAIKFGKHGMVIHKYDSASHAVSPIDDAMLRAWVGKDTDLAEVPPQEPVTALSDYVICELMECFSHDRRPLAFVLRSCKGVVRRLDFYKEEARPDTLPADAYRLDPYGARNKKHKISASDGRKPLWSTALERAHLLKIIDTIELIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D865</accession>
    <name>A0A061D865_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0102440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766101.1">
        <property type="nucleotide sequence ID" value="XM_012910647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D865"/>
    <dbReference type="GeneID" id="24562456"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102440"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="822"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR93915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="957" mass="107377" checksum="021A70B91B53647C" modified="2014-09-03" version="1">MAKILRAASVICAVLFNWTGVIDAYICNFSRPYDLLRRNAVVRCDMDVSILSSATAICPRRVDDAEYVWHPQPTSDGHPHIETYVNVNGSLRSTGISDVVITENQISFISVESNQLQTKLQFNFPSHELFTVIDRRLIFICGPRDLVLSDTMQRHIYGLKDTYNMDLLPWSSSAPLVEELKEMRKGFGLFLVNIGHSHLPLQGCGSRTSALFSPDNVVTENSFTGTRSCVADPRLRAPIGFVCEGRIEPNDCMKSLINQNDEVVPAPEPHKYWQFDNYMPWVVAQYFDQLALPPFTGECRCIDPETGQVKARIEIRSNTEYVCDITQKVFLHRTNPIPGPWCSVVLHPGSTLTIKVPIQKVYRKSFDGSPTVSFSQMMSLYAFETAFLPKDLMTLRQLQTIYNLASYDEIPYTQTLVGDALELDVSQISRGLVKLKYHMGRPLALRREHNSFLYHWTVRSRNVNIHESISAAINVAFAFTHHYHAVGCDRGPQNLFAPSISKLFCSTKRWGNGIGETYECTYDLTMGILWAGIHCKPDEELLPSNCDSAVYDFYSNGAVPLPTTVQHATAIRILGFQTLGFKDHNAPTSIGCICVDQSGYEKSRLIFETNDYAGRRYTVNDGELINISHSYRLLPWHEIGLTGGLPTSPEYLVLNNVSQEVITLRGGKVLFVRCSVAHGAHEDVNDDNIRPMWLPASFRTSHYITMQTPDGPEFVLAAHSDSIATTPGGFEVFTIISTARNYELGIKSSRKAVIVSKDPLHTHEVPMTFVCVKTPEQSDFSVVTGDALTSGEDVQRNVRKIESPHGYKWNVVKIKLKITDPYMHGCGVTYESANLFKPETPPIYDFHGRQIGCTIDLQAAKEAAFYCPAPYVFDPPNCFYQVSVNGEVKNISYVSTSLVPSRTNHFVTLKLNGNRVGPGEELRQSPPLECRCITIKGVVLSTIQIENYYSKEWVAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D872</accession>
    <name>A0A061D872_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0202760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767305.1">
        <property type="nucleotide sequence ID" value="XM_012911851.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A061D872"/>
    <dbReference type="STRING" id="5866.A0A061D872"/>
    <dbReference type="GeneID" id="24563660"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202760"/>
    <dbReference type="OrthoDB" id="5781878at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595889" description="VWFA domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1255"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="115"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="618"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="945"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="966"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1160"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1176"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1222"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1233"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1318" mass="144274" checksum="BE9B0792D2AF7F86" modified="2014-09-03" version="1">MLGVGFLFAFAVLSAICSGYTSAYGSAASSSHSPQDVAGRFVPGNDIRQEIGQQETNVKSGGLGEPHMNSKERVVERSRKRYRRGLSNSRSLDSLSNSERRGNNRHSYMSGVGKDYIIALELMSRLSNTSWNKKLSAFVKQLVQALSKLNGKNRLSLVTFNSTSEIWLDRGFINNETVRSVGKRIDKMFESMTLVEEAKPGEALEFLRQSVYNNGDKYLLNDKTTNLDLNSAAGKDTVVFIITSGAAGDKELAMQEAFDARRNGVTLLVIEIGIRSEKFWASIVGCRQHFGCPQYITTHRKDLMSKVEQVMKQVRSHRRKDAICHEEWSEYSACSEPCGTGIKTSTLISFKTLLSPSNGKGEIIGRTCEKQLQNVKVRQMLCNMQPCRGSRSVGLNHGIGGFIQTTSGNMGNGNTSPLVNKYPSLIDMDAETMDEEDDDDLDDLEEDEEDDDHDQQGLNDDDDEQLLHDYLTNGTYDDDLYGDKTGDYFDDLLTEDTHDKMPKELPANAHKEMHTQEFELERDDEMEEQAADKSIPVENFKVKSEWYEPGVRGVPIKPLETKKEVDLKKMRIANIRKNTLPPSHIPRLYDDDKGIDDMLRYAPDVNRRIGNCKWLGKDYVVALDDSAKLKDVGDYEKVRSFVKMLAYSLSATVGTNTLSLVSYDKTAREVLGRTIIDKDNIRSVAVKIDEMFDTKNSAEEANPGAALKFLREKVYEDREKYLVDDKTSEMRLVDAPGVNTVVFLITTGKVADEVLASNEAFNARRNGVTLFVVEIGKESEKFWPAAMGCRYYYVCPKYITTSASNIMGRIEYVIKSVCSRDGRDAVCLEAWSDYTPCSVPCGSGVQTANLLGFTQLLGPSNGEGEGKGRSCKDLLKNVKVKQVLCNTQRCGTDGSPIAAVGGVDSVGHASTELPKDGVSGVRTDEAENVMPGTRNNEVAVADAGNSANVESQNSDSLASHGSSATEPREVAITESDLPKEGDDLTVHRETEGSVSTRSEADLSEQKGERTPHSESTVVGVHEHNVREGLGGQGDEESTPGSLDVGVTQAGGDSEREVSSGTTHEHQQMENQALVPDTITSVLPTTESESARNPEEEPASQETELTEQLQSEQLENGTTGDESITTELHTTGSSTNTIEGGLTSGQGSEDSGSHANVGDHTQIDENKGLSDAHHLGTDNTRPSGSVPTYEIESGTSTAHHERISEHQEAEREPASVHVKAPGHTSTGENQPENQSREHTTGGRRGEDRDSNGTGSVIMVSAAASGILVLVAAAVFRRYASDMNDDVVDEDNEFLSGESGGKTEEAETYRLADASDNVWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D5</accession>
    <name>A0A061D8D5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YT521-B-like family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769142.1">
        <property type="nucleotide sequence ID" value="XM_012913688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8D5"/>
    <dbReference type="STRING" id="5866.A0A061D8D5"/>
    <dbReference type="GeneID" id="24565497"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308590"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="238" mass="26744" checksum="9FB380CAD670F240" modified="2014-09-03" version="1">MRSRPGNCSVQNNVFCLPNGRQFNGKQFDLLWIRVVELPFSDCVHLKNSFDDGRPVKVARDGQRIDQSTGKELCILFENRFLQKPIPWQPEMYGSQYGAYVINPQGYQCVGVAPGAQTIPPLSGFPVIPISHAPVDLQHIGVVAPYYQVPPVSSPRNQKRSRSGATPQNGQAEKPTDVEGGYRMTEDHALKAAEYNPALAIFPVDLTNLSYEHYISLYNVSHQYWIEQQEPDVKPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J5</accession>
    <name>A0A061D8J5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769217.1">
        <property type="nucleotide sequence ID" value="XM_012913763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J5"/>
    <dbReference type="GeneID" id="24565572"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309340"/>
    <dbReference type="OrthoDB" id="378673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="306" mass="32899" checksum="9EB189F4B028CF19" modified="2014-09-03" version="1">MAPKAGVKGNECLPQAYSNVLAGTAKKAVNNVPLRERLMAQGVYTASTSTEARSAAAPLFSPQKPARRSVKGKGTSTSLPKVGMSRYFQRKADVNGRTSLSNSISHDTGALHTGELRHFASVADNEGSFAFMLDPVEVARVKEHSEALLATLTCEESDCADVQIVDTSSLDQLAAEMPAAAFGGSSCVPLLNNPRGACYAMLRVPPTSHFGPFINTSGVMVLIFIDLPPGKLFYESLNLTGKRKVPCPRQAHVLVLPDDVFKLHNESKTGEASVLMLSCRRDGKEFNIEQHVQGAFLTPIRQLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Q4</accession>
    <name>A0A061D8Q4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767470.1">
        <property type="nucleotide sequence ID" value="XM_012912016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Q4"/>
    <dbReference type="GeneID" id="24563825"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204420"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="6775" checksum="4A2863F387C38974" modified="2014-09-03" version="1">MNLSAKRTSRGGSPQREDAFSIVTDNIGLDSIRHGIGRKFATLMQLRKEIQADSRATNNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8R4</accession>
    <name>A0A061D8R4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-DIRECTED RNA POLYMERASE II, III, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0308320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769114.1">
        <property type="nucleotide sequence ID" value="XM_012913660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8R4"/>
    <dbReference type="STRING" id="5866.A0A061D8R4"/>
    <dbReference type="GeneID" id="24565469"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308320"/>
    <dbReference type="OMA" id="RYCKEST"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="5">
        <location>
            <begin position="75"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="167" mass="18447" checksum="7B27E4ACFEC05D53" modified="2014-09-03" version="1">MFKNYIVEDLVTLEVAEYLDDAHRKLTEKVISGVGLVVLVQEFSVHSEPKILPNDASALFTLRLKLLVFAPEVGELLSGTVVGSDSAGIEVSLGFFSDIKLISLFMPQNAAFDQEATTWYVVENDAKRYCKESTPVSFKVVEVTYNDTNDPSKDDQLPVMLVIGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S4</accession>
    <name>A0A061D8S4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAJOR FACILITATOR SUPERFAMILY MEMBER, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0308470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769129.1">
        <property type="nucleotide sequence ID" value="XM_012913675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8S4"/>
    <dbReference type="GeneID" id="24565484"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308470"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="499" mass="54576" checksum="8228B7254250FE08" modified="2014-09-03" version="1">MEGRVQENSAQTTNNKLEYTLLGRALYKLVSFFEGYDQQVLSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCLIWGVLADKYDSKLVLGGGLLVMGISSIFLSSASRYKVILFLRFLHGFGFACVYPVQQKIVSDTTSSEEEKKPQSSLGSTASGPAQTQGTSLKPKNSQASTKFTTFQALNCIGRLLCAVITTLIARKVLLGYYGWRTSYVVLGYVWILFGTAIVFGMNKARDDVSRSQEFQKLISEAFEQAFTRPTTWILIFTLFIAEAPMSAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSGAGGKIIDKIAGNYSHYYAEIGSGIAVMVVRLVVCLVFFLGKAPCGKLLWYHYVELATLGGTLVTVGGVDRALLKSAVENKYQATASAMVRTISGIASSVILFQVSAYLTEKVFGYVPSRESFETMATDIKDRNAEALRKSMMYIILAGTLLNTVCYIALFCRYEKDKDVVKSNNEKHKNPASEAKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8T0</accession>
    <name>A0A061D8T0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769307.1">
        <property type="nucleotide sequence ID" value="XM_012913853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8T0"/>
    <dbReference type="GeneID" id="24565662"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310240"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="14188" checksum="EF61DA709220070D" modified="2014-09-03" version="1">MAWSLTSAKHGNVRNNVKAKKRHVNVHVVNRNVEINKLTPAKPPLHALSLLQAASQAQLSDPPTEESLTGVPGTEASTPFSPDPQVIAAVVVALIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U2</accession>
    <name>A0A061D8U2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MerC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769317.1">
        <property type="nucleotide sequence ID" value="XM_012913863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8U2"/>
    <dbReference type="GeneID" id="24565672"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310340"/>
    <dbReference type="OMA" id="HAYENVV"/>
    <dbReference type="OrthoDB" id="366078at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015097">
        <property type="term" value="F:mercury ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004891">
        <property type="entry name" value="Mercury-R_MerC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03203">
        <property type="entry name" value="MerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17426" checksum="159A9B053BF426F2" modified="2014-09-03" version="1">MEASELDPWNLRVGSYGWMKLRLRRAGLFLLNYAALLCLIDCIVLPALITLFRLLDMFQNFHAYENVVHVVEIACVIPLGLLSVFVNYRKSKRRRYLAQGLCGIVLVVCGHQLVEGWYDTALSLTGCALLVSSNHFASRESGCHNCHHSHLPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z0</accession>
    <name>A0A061D8Z0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0310740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769357.1">
        <property type="nucleotide sequence ID" value="XM_012913903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Z0"/>
    <dbReference type="STRING" id="5866.A0A061D8Z0"/>
    <dbReference type="GeneID" id="24565712"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310740"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="98" mass="11089" checksum="C0FF3B978A3809D7" modified="2014-09-03" version="1">MGKCGKGTGSFGLRNGKTHILCRRCGNRAFHNQKKRCGSCGYPDKKTRRYNWSFKAVRRRTTGTGRCRHLKTMPRRFKNGFRSGTQPPAKKKTGPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z1</accession>
    <name>A0A061D8Z1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0205070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767535.1">
        <property type="nucleotide sequence ID" value="XM_012912081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Z1"/>
    <dbReference type="STRING" id="5866.A0A061D8Z1"/>
    <dbReference type="GeneID" id="24563890"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205070"/>
    <dbReference type="OMA" id="WKAREMI"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="220" mass="24345" checksum="7AC3AE2BDB821CE2" modified="2014-09-03" version="1">MGNFMSSAFNVAGSIPERYNQGFERLQTLLLKSKFRILLMTSYFVFLPGPGDATACSSLMPTPPLLCEFTSHFIDRMKSHLGDNAKLVYATNPCRIRHLTKRMLFCRSDLLNKLLGTSLLTSGSVQNTTSPSDLKRMLVTTILGQGHLCPSKPGCSTILKYDAALLLYPVPDLICVCDISCPSFVETYNSTVFCNLESFSSSRSFITYDAITGNCQKFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D919</accession>
    <name>A0A061D919_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768658.1">
        <property type="nucleotide sequence ID" value="XM_012913204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D919"/>
    <dbReference type="GeneID" id="24565013"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303760"/>
    <dbReference type="OMA" id="YRIMRPE"/>
    <dbReference type="OrthoDB" id="364838at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="137" mass="16058" checksum="B1FBFA7B541846B8" modified="2014-09-03" version="1">MRRRLPRLFSFRGFSSQAKDRWQLTDEHRPTVSALDKYRQVLSADRRKAIRRSDFLKFTGGRQPLISSHLKANLLGMCPSGIFVWCIFACYMTYRIMRPEDYAWVDAERQRIEAAKIKMQRIIELEKRGEAAGTSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D944</accession>
    <name>A0A061D944_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769402.1">
        <property type="nucleotide sequence ID" value="XM_012913948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D944"/>
    <dbReference type="STRING" id="5866.A0A061D944"/>
    <dbReference type="GeneID" id="24565757"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311190"/>
    <dbReference type="OrthoDB" id="366708at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="19426" checksum="171F27BC98F943C2" modified="2014-09-03" version="1">MVGACGSDAILGLRVGNSSNSGSYLPLLYTHGITLTEVGSQVSLKCSDVITKLKEIVNGRPIASLMTAMDNFLYGIREPFIFTLVALWSLAFLICANTMLYRLDVLHIRSHLIRAKASHHIDVKALLTKGRKMLSLYKDVDYFDEDPIGYIDYWPPTYAIGDGHATILRDGQWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D995</accession>
    <name>A0A061D995_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0304600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768743.1">
        <property type="nucleotide sequence ID" value="XM_012913289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D995"/>
    <dbReference type="STRING" id="5866.A0A061D995"/>
    <dbReference type="GeneID" id="24565098"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304600"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="122" mass="14215" checksum="A88E7F0D21BDA005" modified="2014-09-03" version="1">MATSVDYEISEDDQSRIVEFSTVFNKKNMAETRLKALKEQVQNIDDAQEELMINMDTPYLKIGDCFLRLEESELDEHLEAEKKEATDEIRQLEQEIDEHIARTAELKAMLYAKFGNRINLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A1</accession>
    <name>A0A061D9A1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769309.1">
        <property type="nucleotide sequence ID" value="XM_012913855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A1"/>
    <dbReference type="GeneID" id="24565664"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310260"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="7500" checksum="0691C02A160BAAB7" modified="2014-09-03" version="1">MGKSFCGQDNCKGCATCAGIGLAIAFAGFIGFSALLVLVLYIMGRLYNVSLGEILNQIRDGFRDSKPKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9B0</accession>
    <name>A0A061D9B0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769319.1">
        <property type="nucleotide sequence ID" value="XM_012913865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9B0"/>
    <dbReference type="GeneID" id="24565674"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310360"/>
    <dbReference type="OrthoDB" id="365634at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="382" mass="40731" checksum="AB16E782D03CA3FE" modified="2014-09-03" version="1">MLMGDAENLSLVLPQRLDAVGVWDGTQATVFQHRGPVFHKLATARRKGALVLTTEETVYALLRTKFALFHKDTLERVTAEELLRGIVASREFERLLRVHVYLAVVAQGTAVERISKNADIASLDCSAPCVHGDEQRQNQAAAHASHRTIDPSSHGGTALDPDEAITATISNNTRDGGDDNEHNGGNCASPSDPAALQAEPLTGSSTRLPNPTNGKPWPDIETLNDALQRIELDGAKCMPHELLQKFRDICGTIYPVEPVTIDAPIFAIEGAPVYAVTADTMCSKLLGSSATGIKCNYGHSDDGACLDATSNHGTKTFSETEAAEKGMGQISQCKARQAGVPNGNDSCTMDGAGPVGANGRCVVAVSNFDTVYFLDVKNNITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I2</accession>
    <name>A0A061D9I2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">5'-3' exonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0106840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766561.1">
        <property type="nucleotide sequence ID" value="XM_012911107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9I2"/>
    <dbReference type="STRING" id="5866.A0A061D9I2"/>
    <dbReference type="GeneID" id="24562916"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106840"/>
    <dbReference type="OMA" id="NQEGYHD"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="6">
        <location>
            <begin position="72"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="678" mass="77765" checksum="95493CD5FFC7D1D5" modified="2014-09-03" version="1">MEAVALVTAICSLLTTRPEKVEATAPCRRAGHLGTAFLYPGAPRAPQGVTLERRLPNTWSANRGNRNQPLYGVPRMFYWLLDNFGGFKTALERALEKQPVDHLYIDMNAIIHVATHGNVSPLVQMENEQRLRRITSAIEMLFNVVQPRKMLYMAVDGVCPTAKINQQRGRRFRTSKSIDQLVSVASLDPHGVQTEICSAVSSKDGEKYVAQRLPFDAYDNVTFNPNYISPGTDFMQIVDSEVANWLALKTVEGLFGKCLVVYSGVSVPGEGEHKIFQCIRKMNKASRHARKETHLVYGLDADLMMLSMALKIPNIKVLREEGKYAPHVVAKKKGEPFFATDTGIVHLHKWDFIDLKQANFEVVSIRTLRKRMYERCLRHLIKKFRASNFAFLNRPEAPYRITDDFVLLSFLAGNDFLPRLPTVDFANDSFSEMIETYYSLLQRWKGFLTDGLKIHVPRLQSLFKALTKNEQRWFKEKALIEEVEQYSNPKLYADYYHREKCQVDGKAEIRRMCVDYLKGLFWILSYYHHDCPSWDWSYRYHYSPLVSDLADVTKVDVTFNKGGPITPLEHLLAISPPNGNELLPPSYRKLAKEDGELRQYFPTEFDINEDGRTNEWEHVVKLPFVNTHKLVKAAQKVNPGLKYSSLYKNKKGHIYVYQQPREPDPPTADEADSGKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K1</accession>
    <name>A0A061D9K1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766586.1">
        <property type="nucleotide sequence ID" value="XM_012911132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9K1"/>
    <dbReference type="GeneID" id="24562941"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107090"/>
    <dbReference type="OMA" id="ITRIWIA"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40765" checksum="EA15AF1FAC334456" modified="2014-09-03" version="1">MSQSCTSATRYGDDSETWRARMSLWLPPPWYHVLPHLEKFREASNMHIDLYTDNKDEVLGGEIYHLMCREGNICTLCTNFTYRTHLSRARDAAARDAMANGDETAGSQSPGSSVGARLSDFNADESSDEEPATQQLANRPAVVFLIFTKEDIVKLSVEMLRQRITTTIELFQVLYPNVKILVVMHAVRLYALHGQNSPTDSQSPQRDSQTPVMHNLTLDDIICSLMIEYQVDVVEAEDDVELAKFIVDAASAAELCATRRGASGFRAKPQSNLSQDTSLATNTWITQLQQIPELGQEAATAIAEMYSTPVEVMEAIEDSPDKLVESLSNLSSGTRGSRKLATAIANRIATLFSQNVEPNTFVMDNCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9N1</accession>
    <name>A0A061D9N1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0107359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766621.1">
        <property type="nucleotide sequence ID" value="XM_012911167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9N1"/>
    <dbReference type="STRING" id="5866.A0A061D9N1"/>
    <dbReference type="GeneID" id="24562976"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107359"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107359"/>
    <dbReference type="OMA" id="ADMYLEM"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="519" mass="58131" checksum="F1D28CA30698FA66" modified="2014-09-03" version="1">MKSEFCHDLSKPLAANDTVILMIHNKGGFTARIEPGKTIKICKDTFPLDMLIGCSYGDIFTKETGCWSKIRRNDPQYMQYRHRVREDYNEDQPESVTNNRDINDDNTAQKLTYDQIQQLKKDKTSHEVIETIVDNSETFAKKNRMAQEKYIQRKEARHTKLFYVRPCDLYNVCDCYFNSFPHKIGFLNFANLGMMLYLADIRYGHKVMVLDHALGLITGAISQRLAGSGKIYRLVSKGVSDKIVHELGIKYFDNIFSIDMDRYIDSGDAVELDETAGGAHGTAGADAVMASRPDTKMADETEGTCPPSVQEVSENGESVPKDNGDEVISCDAQDGSQLEGSGKRTCVAEYNSDDTLRGMHASICVNLASDPKKKRVTLPGIYPLHNPSRDEVSGCQVIIGNIAFNKCDKLNRVVAEYTRKMKAAADMYLEMGGRLVVFGQQYQPMAELQASLTLSDEYVNVKFDEMFIRQYQVRSRPQTLIGSADAAAEDAAANDAGRPPVLRVHRLRNQELEGRDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA72</accession>
    <name>A0A061DA72_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0313400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769624.1">
        <property type="nucleotide sequence ID" value="XM_012914170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA72"/>
    <dbReference type="STRING" id="5866.A0A061DA72"/>
    <dbReference type="GeneID" id="24565979"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313400"/>
    <dbReference type="OMA" id="GECCYYA"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="11">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="11">
        <location>
            <begin position="121"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="475" mass="52398" checksum="F09466213B241704" modified="2014-09-03" version="1">MEHSSQCIYRIKPVVRNYDWGAPARSSLVYRLYSHVAGLPSTPPADEAGNTPYAELWVGDHDSAPCIVIDLKTRVPCASRVQEATDGPEHGSTGSPSTSSTKGVTQGFTPSNGQGERLSAVYKRMGMQLFGQENNGVPILLKVLSIAKPLSLQIHPDPDTALKMFAQKHPSIVDCQAKPEMSVALSTFRAMCGLRPLSEIIRYAERYPPFASMIGTDVLECMRQAKPAEVGAIYAKLCRRLLLEQGEINVIEELVKLVKERTDHDISEQVMITLNDQYGKDICVSFAFVLNCVEIQRGEAFFIPPNVLHSYISGNCLELMNNSDNVIRCGLTSKATDTKAVMELVEVEVRRGDAFPQHVNTVTPEKTSPYVTIYRPLHPLCKFAVWLFEVPPKTHVSHSFNNGTRPFLCIIVETNDEVNVSYGLAEKGKDEVATASAEEQVPTGLGDAFFLYPNVALNVKNNGDSHFVMYLGTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA76</accession>
    <name>A0A061DA76_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769629.1">
        <property type="nucleotide sequence ID" value="XM_012914175.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DA76"/>
    <dbReference type="GeneID" id="24565984"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313450"/>
    <dbReference type="OMA" id="EQMIYET"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1424" mass="158179" checksum="11E3651696D16A1E" modified="2014-09-03" version="1">MDSLPSHLTSVPLPCAAVSAYSDGHSKLRDFIVTAGRAATSNNRDRMKVDLYDGSKIIHDDTDGAQHWELEIPEDADWVLLQRSLPPCIVCVRDWQNYVVDASWSAGNADDGAASQDDAKTSSQSDPAEDDSFDAKPANESLLIRGDMKQLSDIIKSDVERTLNAYRKNVLGRKPVAGRIMFLILLRKGTKNPHKAVNSLKNLNANEVAAVCVTCGEADIASKLSKLEQLMYEVSLAYYERRAHLLAKALSKVKPSAGPTVDETSEINAAMAYFKLAYFHQFVANFKESVHALGQAWSHVIPAVMCRPCEEYASVALYIALQMVGARFACSNIVEALTFAFEAAAFFKRFFYSDGLLPLYHNLCYLLHHSVAVHLDKANQYKELKANSHIRQHAANFYKWSLRHLMQMRITLMSQTDVTEFPRKFGSLFFRDDEDFGYLYEGAAAERHGQSKERRVRYLESVTEGILVKLMDMLSTCSWYQTLLEVTDILGDSLFLSFKLREAFFIYANIAESLVNPTPLDTDYLLKSCSSSVISEALKVSTTARSAQRTDSNAGQDMLSLQPNFLKTSTTMLLAEHAHSKVWWSLYELVLSKMMVTLNLLLGQPLELPQSVMKAANLPTSIYEEPLRSKFELENSPRLDIDMLTGSARREYSLILLKSMLTLHSVKGTPFDFEPTCNWLLSRLSPRHDFLSSILLSKHHQAQYMLGRAEICDDTIMTTLQILVSFHVDLPFGVEVSNVTICTSIGTFAFDISEVLCINDRVEIYTTPCAGEHTTDASGVKREDSLSSEGVSGGRAESSSEDSGASDGDQSARIGEKQPEVVSDATRPAAVSKTAVLRGDSHVLLAITCPAINNKFMVDNFVLLGVNLLWVKDMADGTSVNISCVMPCLTLRLAHGIPGIGDTMFTADPRHGVFRIFDDVAAVGAVSASLKSEELLDTIAVNPKRADSCGIVVDTLVELTSVSQCLLDFDELVDSHSSASMPHARGAYRMFVNRIYFKAFLGELVEGHVAPVTCVLLYNKNILKAEYLPRIRFSVEVTSSANSFHFYALCRDGADDSGIMRLCVNNKFSLTLTGFADAQHFDLGTRLDTRSGPDADAVVPTLFADDPAVACSINEDMTNFLELAKRDSNTGVVYLFGLFKALSHGPTTVKFNLQMQPMLGHTLKAMESQFLVVTDVTKTFVHEPVSLDLAVDQVYDNDTGGYMKFLNMHLSNKSPLQYSLDSVRVLHDGISVAQNDQLYGYRKTMEDREGLLFMYLCPTNKHGESGMEVQCLHSVVHADAFPYNRLQPCFQIMLTKNISLYNEKDHCEILIAVKHQSIVELGQPFEFVAEIRNMTPHTLDYCITLPTGGATGSPFMISGPRYLDMIALPHALRTVKWVLMANKCGHHNLPEVRLEQRRKLSLSRDDFVSVPSLIYVTPRPLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI2</accession>
    <name>A0A061DAI2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VACUOLAR PROTEIN SORTING VPS16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0110280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766916.1">
        <property type="nucleotide sequence ID" value="XM_012911462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI2"/>
    <dbReference type="STRING" id="5866.A0A061DAI2"/>
    <dbReference type="GeneID" id="24563271"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110280"/>
    <dbReference type="OMA" id="RICEFFR"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="344"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="823"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="992" mass="107438" checksum="44C7298C53552FBB" modified="2014-09-03" version="1">MVARVPPSTCHTLGARKLRRESWRLTGEQWRCCLGDAWAVAPLGCVVAVVTSRMESADALPENVKCQMRIFRGGTGSLVTCVPWLVRLDTLMALQWTDSMLLAAIFRNSCVRVLSANGDFMHYFHLFFAEEVAQSYTIDSSLVTLCTWGGGAVYVSKEKACLYVQRGFEGRNCVHFPLGDYSLRISALGVLPHEDWLESVVIVARVDGACHVVMRELLKCRDHEDFQRCATEISHVEGLGFDEVVFCSHVAPGCEETYFALRDSSTNTVVSMCHRNGRVQELWRTALGKSGDLYVVGSGALALVSGDRITFLYRDADADQGASGSIDKNNFTVKPLCVSSDVGGGLRVFTASSGEFFKLVSPAAETVLTSYASDPASVLLRAYEMFQSGDVKACESLRLIRDDVMDAAATCVTASLDCWDIDTASTLLDAALFGRSMNSVQAERDHDAVSPGPAAESVSAAASMDGSVDSEKGRPQKNYAAHSSSRGIRGASSTGVGTSAGAAETAADAADTANSTAGARQGHVGAAEDQPVQGHATALAMIRVAKALRAAPSEICTNPSQLLAFGSRALVGMLAALRFHLLALKVADFLGADKKDVLLHWVHTRVKLGNHMTDEELVEVITKLLDGYAGVVLPYADIAEAAAKEKRETLALALLDRERSTLRKFSSLCSWGELNKAASVAAEACDTLYAAQLIHEAQVGSKLDRVVEISNSNSFVRDVFIKQCNLEGDSDVLQVFLERTDDIVGAGRNAVRRALEILQPRAAEAPESRPRSAMHQLVTHAAAQQNTQSEDCVTWLKYSSDFFRAVVASKNNRSPGVVETAGLWNDCVSQQRELLTAQAALERSSPELAKAGLVGRSLVHTVFTLYRLDMAKKAEALASKFRMPFNQLWRCQLAAAHEVQNINELLRMAMDKSAHSQYVMLKNGKEPVDLVLEALLSLGATNAVESVVATLRSPHQQRWRNRLNSRLGGGGSAESDNQAQSLFASLSKRIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAU6</accession>
    <name>A0A061DAU6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0310200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769303.1">
        <property type="nucleotide sequence ID" value="XM_012913849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAU6"/>
    <dbReference type="STRING" id="5866.A0A061DAU6"/>
    <dbReference type="GeneID" id="24565658"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310200"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27777" checksum="811AEF18A1213A4E" modified="2014-09-03" version="1">MKLNLANPYTGMQKTVEVDDEKRLLPFFEKRMGAEVPGDSLGDEFKGYVFKISGGNDKQGFPMMQGVLTASRVRLLLKKGMKCYRPRRTGEMRRKSVRGCIASPDLSILNLVVVKKGPQEIAGLTDEDRPRRLGPKRASKIRRLFNLGPEDDVRKYVIRRKIEGRNKTRAPKIQRLVTPQRIQRKQRRVALRVAKEKASRESLKAYFKMMEEYKASKAPATEAEAAEVATRKGKKGKKVQSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB28</accession>
    <name>A0A061DB28_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769373.1">
        <property type="nucleotide sequence ID" value="XM_012913919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB28"/>
    <dbReference type="GeneID" id="24565728"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310900"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="85" mass="8848" checksum="F9D1B2DB5C6587A5" modified="2014-09-03" version="1">MEKKSSRDVEGRGQAMDLGTSVPGAGKTGLEVPGLKAEWGIRAMLDATTDAVTIVGGGKVEQGKLGRSDMPLTPQQLEGAPVWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB64</accession>
    <name>A0A061DB64_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768340.1">
        <property type="nucleotide sequence ID" value="XM_012912886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB64"/>
    <dbReference type="GeneID" id="24564695"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300590"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="83" mass="9152" checksum="0C10FFEB2D394CD5" modified="2014-09-03" version="1">MGQTCSKCKDNCSSGRDCADCPKFSCNCQCCRKTGAYIAAGVLFAIFALIFFSSFYYGFPAIPYKKISDVFRSSMRDTYSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBA7</accession>
    <name>A0A061DBA7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">-FAS-associated factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769984.1">
        <property type="nucleotide sequence ID" value="XM_012914530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBA7"/>
    <dbReference type="STRING" id="5866.A0A061DBA7"/>
    <dbReference type="GeneID" id="24566339"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402860"/>
    <dbReference type="OMA" id="YFCESIF"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="261"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="354" mass="40006" checksum="6C7D016E5A7C9325" modified="2014-09-03" version="1">MDTPKAVFSSVSRYGRHFFKLLRDTITHIVAYCRVLPGLCYRIVSNTIGSSSDSFHKYFESRHGTSHPKFFEGTFQLAQLSAFRNGKLLAVCLHSDSRDELCASVLTNSLVIDILDSNFVFYVEHGKGPRMRNLIQRLDARRLPHMSVMVMRSYREYAVIASTSDFSTASNVVSMLVGAIENPVSSAGARSDDLSIHRQIVTEQDAELQKAIEADVARMRSKDLRENNDLRRRQLRADNRLKRQQLISDRKEFARKYAATSHTGNTKIKVRLPSGRTIESVFNKDDTVGMLYDWVGAAEYLCDNQVKIPYAFDLSIPHPSTTLGDRAQTLEKANLYPNASLVLISRDDSDEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBD3</accession>
    <name>A0A061DBD3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ran guanine nucleotide release factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0301190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768400.1">
        <property type="nucleotide sequence ID" value="XM_012912946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBD3"/>
    <dbReference type="STRING" id="5866.A0A061DBD3"/>
    <dbReference type="GeneID" id="24564755"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301190"/>
    <dbReference type="OMA" id="QEVFVYH"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22507" checksum="1C970CC6980C792C" modified="2014-09-03" version="1">MIQHKRRLYGGSIVCGIPQTFQDLSDLLPVPDHQEVFINYRSAVEKDKNRVVARTSECVLSFEILEYEETGDDEIRARHLFHELASWNEADRSSTITIETVKTPDSIGVENCKAIILVGTMDVTKSSRVPQDDVRHVSVFLYVLRLREYRCDILVSYNFPLDDTDDEYATQLTMFKDITHSIQIIDDKLFIHRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH9</accession>
    <name>A0A061DBH9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0202620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767291.1">
        <property type="nucleotide sequence ID" value="XM_012911837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBH9"/>
    <dbReference type="GeneID" id="24563646"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202620"/>
    <dbReference type="OMA" id="PVYMPFR"/>
    <dbReference type="OrthoDB" id="366009at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600773" evidence="2">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="183" mass="20134" checksum="9E35D4BFE7045CDB" modified="2014-09-03" version="1">MPRATSLLLVIAACTAASTVSAAAAKRRGGAMDVLAPHLVNSAVSMLTGTSQQDTDAPHISLKVMPSKRIHLSPSEMNALIFTIKQEIHRKDLLERRHENEKHLSAWALNQAPVYMPFRGTNIAHDRYDARPDNPAQDKNKRESTLQMEVQKIKQKADAETSVGKPATVSSDAHNEKKEPDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBI4</accession>
    <name>A0A061DBI4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770094.1">
        <property type="nucleotide sequence ID" value="XM_012914640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBI4"/>
    <dbReference type="GeneID" id="24566449"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403960"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7137" checksum="E951BF0A747C60B5" modified="2014-09-03" version="1">MASVFISTLSLYLTVIIYALSNVSVAVGLQKYGKKDLGSALFFIGSVSFFVGSLAYVIVPFITPPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBP0</accession>
    <name>A0A061DBP0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">-ATP-dependent RNA helicase DBP9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404650</name>
        <name evidence="2" type="ORF">BBBOND_0404670</name>
        <name evidence="3" type="ORF">BBBOND_0404690</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Bond</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770164.1">
        <property type="nucleotide sequence ID" value="XM_012914710.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770166.1">
        <property type="nucleotide sequence ID" value="XM_012914712.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770168.1">
        <property type="nucleotide sequence ID" value="XM_012914714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBP0"/>
    <dbReference type="GeneID" id="24566519"/>
    <dbReference type="GeneID" id="24566521"/>
    <dbReference type="GeneID" id="24566523"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404650"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404670"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404690"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="102" mass="11019" checksum="BAEAC13C64251EFC" modified="2014-09-03" version="1">MVSFEESADETVTPPSVAAKSCGDNDSILQFGRHRLHPTLVEALAGSYGTFTDIQTKAIPQALAGKDILVKAQTGRIRAALHLMLTSNERISSALFRNTCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT3</accession>
    <name>A0A061DBT3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770219.1">
        <property type="nucleotide sequence ID" value="XM_012914765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT3"/>
    <dbReference type="GeneID" id="24566574"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405175"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405175"/>
    <dbReference type="OMA" id="IKMYNIG"/>
    <dbReference type="OrthoDB" id="360364at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="1">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="358" mass="40627" checksum="20AB5EC906324AB6" modified="2014-09-03" version="1">MEDSTPTGSDSATIAELFSIDEVDFIGAKDSTNSSVLNQILSDLRKVGGPNSVCKTDQRPRDETKSAGYKLLLKIVENVLLHPWEHEKRRIREQNALYSRRIGNDDQMKAVLVALGFRSIHGYAVLQVVDVPLLRLAYRSLIAALQEEYSVSVKSLEGHFFDPFKAYRHSSDVNRNAYTDNFECVGKDLTKRQIDKLSDKLTSSVITSINEWNPQIHVDEGKLRPKITQKTSEPDVQEDKHAASHLKKIYDIGKCDFESASQKRLEALNRQCEQAEQKQTVELKIRLPATTVLTIHPPLKTPVATLKQEVQTLFVPGIAADDWELVEMPTRRVLDEHKTLLQQDIIHRVLLHFRRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBV0</accession>
    <name>A0A061DBV0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0203880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767416.1">
        <property type="nucleotide sequence ID" value="XM_012911962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBV0"/>
    <dbReference type="STRING" id="5866.A0A061DBV0"/>
    <dbReference type="GeneID" id="24563771"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203880"/>
    <dbReference type="OMA" id="HIHYVTD"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="3">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="103" mass="11164" checksum="F7F62EB642C00B5E" modified="2014-09-03" version="1">MVKQVASVDEFQTVIASPGLVVVDFFATWCGPCMSFAPKFEAMSKDYPSANFIKVDITDVPELQTKYAITSIPAFKLFKNGEVVGEVVGASGINLKNAIEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ5</accession>
    <name>A0A061DBZ5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768605.1">
        <property type="nucleotide sequence ID" value="XM_012913151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBZ5"/>
    <dbReference type="GeneID" id="24564960"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303230"/>
    <dbReference type="OrthoDB" id="366183at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="159" mass="17489" checksum="32FD5F8044DC376D" modified="2014-09-03" version="1">MMLPALVSSSLSVARRAVPRFGTRGFSGRRARRTVNSQMTPQQQLLYQQKLKEMQLAQMQPPRKQGFLDIIKEGAMHGIGWAFGQRLVDSILGPRTMNIGGFNNSSNSNDQVGGGNEGDNMPSGSSGYMNDSNDGSYFDEEGGDNSGWSWGSDWFNDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC15</accession>
    <name>A0A061DC15_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0303580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768640.1">
        <property type="nucleotide sequence ID" value="XM_012913186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC15"/>
    <dbReference type="STRING" id="5866.A0A061DC15"/>
    <dbReference type="GeneID" id="24564995"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303580"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="109"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="420" mass="46546" checksum="755A3956FDF85177" modified="2014-09-03" version="1">MECSITPTEAPPAAPKNERRKKKQPKASSDSFDDLLELESLSVTPNNPLLVDCLPGEPLRRLNKWTTAIPPSKPVHEQFKGRPFPVGAARSNDEEKRHLEKVSADSYQDLRRAAEVHRQVRRYIQSVVRPGITMLDLVNAVETKSKELIAADGLKCGWAFPTGCSLNSCAAHYTPNYGDNTVLTKGDICKLDFGTQVNGHIIDCAFTIAFDEQYDELIKATQEATNVGIRDAGIDARLCEIGEVIHETIESHEVTIQGVTYPVKPIRNLTGHSIGSYRIHAGKAVPIVRNSGCSDRMEEGDLFAIETFATTGKGTVVESMDCSHYMKDFEVGFVPLTLKSARDVLKCINTNFSTLAFCRRWLDDLTGGKNLLALRHLVDKGIVNPYPPLSDIRGSYTSQMEHTILLRPTCKEVLSRGEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC16</accession>
    <name>A0A061DC16_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769728.1">
        <property type="nucleotide sequence ID" value="XM_012914274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC16"/>
    <dbReference type="GeneID" id="24566083"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400340"/>
    <dbReference type="OrthoDB" id="565522at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="176" mass="19378" checksum="98E215557481D59D" modified="2014-09-03" version="1">MGFGVASKLSRLLVSSWLKKDEVKLTVTESDDAVENIEHGEANQIQSIDWNDLNYPWGLNIVHYSANELDDVSAKVSRISHIGTFVVYGTLLLNLVDVIILARQLLFNICYVGNKEEALPNFLHGNAYTTGKLNETFSITDFQCLLYLALAILGEGPINGFTKFAHLKSEIAGCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC18</accession>
    <name>A0A061DC18_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MYND Zn finger containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0303630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768645.1">
        <property type="nucleotide sequence ID" value="XM_012913191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC18"/>
    <dbReference type="GeneID" id="24565000"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303630"/>
    <dbReference type="OMA" id="WSNINIE"/>
    <dbReference type="OrthoDB" id="390933at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="431"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="532" mass="60664" checksum="B1210D470DFC1115" modified="2014-09-03" version="1">MDNVALRRAFLTSRSQNEDPVLYDDSAISTTCYRSETTKDELDELKQLFFHSTLKPKFDWAGLCLERQHDFKFWANVTHTFGLLIVRNIFNSNTSCEDAIELQRMAMLNEDRDCYGHCQEFARSSDAIAYTDDSLADFKTRVSFILLSGLLSNRIPGSLRLIVRCNGYQYFEHRISELMNDFPKFDVSAVCFNMNALRILIPYLLEPQSVNLSNVCHRFLTSRFWRIMWLDVGVGLKQRPSTERGQLFGAFLELASTICYGTRSPALLKRLYGSCLKSLWDPIFAVLTWRLGPKLLCRVLTFVADMLMMSFQDNCLDMLDNSFLSKLSQCAKEALADGERYLSRYLLQTLDDRNEFYHHFARIATEMLKALLQALANAMQGHVNKCVEDLYDISSLGTAKLILPPHAGDSGEAHVRFDYSDTRVFPRVLPCFNTDCKRVFHLDMPQLHVDSDTPEFCYCSRCGVPSYCSAACADSHWEAGHRQVCSFLRAPPTFAKFIAPMPDSGNILLRTFDNECTMAPECDDAGNVLTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC25</accession>
    <name>A0A061DC25_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769743.1">
        <property type="nucleotide sequence ID" value="XM_012914289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC25"/>
    <dbReference type="GeneID" id="24566098"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400490"/>
    <dbReference type="OMA" id="RWIALAW"/>
    <dbReference type="OrthoDB" id="365839at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="29034" checksum="13D338AED6D8E2CC" modified="2014-09-03" version="1">MAWSQCSNTLHCTSKFYDECESASESFLYRERQTTKSSRSSTAAATGSQRKYNLLVEISRSLSWCFGRREGEEEAVGAMCRKPPLQRTNQLYATKARHILWTIEPTTSHRHESWTLNHARWMALAWASRVTNGEPITRRMMNGLLVNAMRSKNAIEGITKAVMKNFQGLELVDNISCFETVDQTTAIDTIVDALSEHSAPNRFYFAIIVKKDSCCYAVYYNHRGDERDVVLLECGVPSKHGGIKCGRMIGFNRLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCI8</accession>
    <name>A0A061DCI8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BBBOND_0402850</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769983.1">
        <property type="nucleotide sequence ID" value="XM_012914529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCI8"/>
    <dbReference type="STRING" id="5866.A0A061DCI8"/>
    <dbReference type="GeneID" id="24566338"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402850"/>
    <dbReference type="OMA" id="WQTMGIL"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="8"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDR97797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="825" mass="93680" checksum="E0606470342FB1C1" modified="2014-09-03" version="1">MVRFWVDGIEVFFPYPQIYPEQLAYLRSLKSTLDAQGHAVLEMPTGTGKTVALFSLITSYQLARPEIGRLIYCTRTIPEMEKSLLELKQVIKYRNEELAKDRAARSKAAVTNGESSAVSVPEPVMADKKSGHDMTSLWRRINYEEDGTTTYREYTMQYEGTGTRGMPTAPVVRQSAVEEVQDIEHYASKGLCGYYEHLERIWNPTMIPSGVYTLEGLKEHCSTFRHPVTGVSVPICPYFAVRRALDMANVVVLNYQYLLDPKVSEAAFSHLYSTSPTDMSKHKDEKPDPKREKKSKLPIVVVFDEAHNIDNVCIEAMSVELNDDTLDEAFCNIAKIEDNVRQLRERDENLLMEEYRKLAENIRESSIDIEGYMCPVLPADVLQKAVPGNIRQAEHFISFLKVVVGYLKHYIKVQEPKSEGPLMFLHRFEIETGIGSITMQHTYSRMKSLLNTLKITAVGDLSAIQLVVDFCTLVGTYSTGFIVIVEPYPQGSLYEPLLQFSCLDASIAMQPVVDNFQSVILTSGTISPLEMYPKILNFTPVLTQSLPMSLDRDCLCPLIVSKGANQLQMSTKFDLRNDVTVLRNYGNLLIELCKNIPDGVVCFFPSYAYMELIVSHWYECGIIATIMEHKLIFMETKDVVTTTLALHNYRKACDVGRGGLFLSICRGKVAEGIDFDRHYGRCVVLIGVPFQYTLSRVLKARLDFMRTNYGILENEFMTFDAMRQAAQCVGRIIRNKSDFGLMIFADSRYSRADKRSKLPPWILKNLEPCNMSLTTESAVTAAKSMLRNMAQDYVPNVYTRFDQDMVSDEAIWWSSVQNVLRLSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCK1</accession>
    <name>A0A061DCK1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0403150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770013.1">
        <property type="nucleotide sequence ID" value="XM_012914559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCK1"/>
    <dbReference type="STRING" id="5866.A0A061DCK1"/>
    <dbReference type="GeneID" id="24566368"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403150"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00006">
        <property type="entry name" value="16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="469" mass="51478" checksum="EF57C5396F1D98E6" modified="2014-09-03" version="1">MSQSRGSVGGSVLQDPVYALYTGQVYEQFQRIAARLAVLCLLVLWLLSLGPGSAYVQRLRSKRCISHISRRCVTVSAAEGQPSVPFSTGDQERENHVGNDAPNLTAFGLPDAARDDHNTSEEGVATVDGTSQQTPCYLRHEPVLLQETLDLLVTNPDGRYLDATLGYGGHSEAILERLSDKGSLVALDRDPEAVYYTGRRLSAYVDSGQMRPVIGTFSNLKRVLESHALPLTGYTGIVADLGLSTHQLESACRGFSYNTDGPLDMRMSNPLHDPFSTARPTGVDLASSLGASNTAFKIVNKARENELAHILKAYGEEVRAAVIARRIVDMRSRKGRISTTKELRDIVVSCVRGNHKAAMKVLSRVFQALRIYVNDELSELQSLLEFAPSLLHRKHGRFVVISYHSLEDRAVKRAFAGLQSASELSPDSSVYRVLTKKCVTAGSAESKANQKSRSAKLRCLQRSRQMTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCT9</accession>
    <name>A0A061DCT9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA REPAIR XP-C / RAD4 domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767946.1">
        <property type="nucleotide sequence ID" value="XM_012912492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCT9"/>
    <dbReference type="STRING" id="5866.A0A061DCT9"/>
    <dbReference type="GeneID" id="24564301"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209140"/>
    <dbReference type="OMA" id="CEFFDTK"/>
    <dbReference type="OrthoDB" id="340039at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="1">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="2">
        <location>
            <begin position="408"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="548" mass="62958" checksum="1AAF4A4FC79FEDF8" modified="2014-09-03" version="1">MPLNPTQALVFSYFENFYSGPAEPLAIFKHIQEHFSILPELRTDTTRNGRGKVLLRLLRCLHLHKGSSDTLTLLYVCACRCYGVSARLVEAVHGPANGVLLLAESFDPDSGSWKRVDFSRLKYGGVAYDPTKSAKPCNREKAVEYAPSESSEYGGRLYVQRDNKLFVYKREPDLRVVAILVSRSRRPSQAVLNVSEFRFEEEEFRQRLVRDKQKPGAKDARQEFHYVFGCNKYGWLSEITPKYVERYNDVCVKRGKELQAWLVQTIERLNEPVKSVSGAGIVSMLERAESKWMETRVSNDPLPDSKARLKNHPVYVLASQIGSNHILKKDATPIAFLKGEEVYLRCDLEALKTRGAWRKANRRVLDDVQPITTRKTYNRNTRMHVNTSLFSESQTELIPQEVATDGSIPTTEYDNVDVTGQRFVPQGTIYLRTKRLDLLLRAANALQLHYKRAFSSYQKTDTFKPEIDGIVIQKANLPALLQKYEELAMEAATKALEEKKESYRNFWRSVFKTMLADPPSVAQEHHNKIRRELNEHVTHFLNRVEHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCU0</accession>
    <name>A0A061DCU0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769070.1">
        <property type="nucleotide sequence ID" value="XM_012913616.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCU0"/>
    <dbReference type="GeneID" id="24565425"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307880"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1689"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1762" mass="191837" checksum="1E5CA777BA23F953" modified="2014-09-03" version="1">MAAKGVKLDTLKQCLEFLYWLHSDRRGKKLQSRVVDELFNIINKYYNNSTFREQLRLSLPAFLNSASKVYNQISNKTTPSNYGGSSDQNIIDAILECLPKVYAAFSLLLFHVDYTYRALGGGFWASEETNSGDNALKSYLTASNDIYNGIIPGGFSEGELNSLQGVKLAHNLNEALTRYISTPDIFTGVLFNNLVNSDWHDVDAGNVLLLLWAFCEYVETHEEGDSELKTNLQEELKKKGMCFEWDMLVEHCKTLKKSLDKLFGNTFDDFSPKPFTTTGRAFTTFALKPEAFAGAFEKWFIDHWDDIGDALDAIKSGVEDLEESTADFSPEYIYPYGIVLNKDQRNEWEQGLKNLPAVLKALGNSDNGDVEKLKEILGGTSCPVQPPPPPPLQPAGPSTSKPAPPKPTSTTTETTKKVVTKPQSTTNQNNGQSEANLPTSSVSKRPSSPSGGAGAPGQAGPKGNQGPQGSSSTGSTKSPPKNNVKQQPPSQPQPAPPPQASPPGPASPASPSQSGGGGGSKNGGDPQPSEQHPSPSAPPTGAPSPATPVSGGGRSQGGQAASSDAGPTGGKSHDSPSGVPTVQQPAQPRDPSVKSPGSASSGAPGPRGGQVSTAVPVPPGGYGQGSQSGGSQGQQTVVPSQPAKPPTTYVHPPDPASPVVPAPGNGPGPGDRGSTSSTTQQSGRVTPQSSTNAVTTTSSGSGAGSGGGGGSGGVGGGSGSPTRNKTQTDGQPKKCYYVNMQNLVHETGDYCPSGYKRPVRVPAYGQRTPEELWNELKQKEEQQREMTQKKQRTLLQDLPYIDGVDATAPLEGYVVQDVLRRQNERNRQFRDWGLAYEQYLKNRHETETNEMQKYADELQKVKAHSDLLNNFGIIDVDIGIPNNSPTVSLEITKAQSSNKNDIKKPVATNYNTPYFIEVVEPNKSSDSSSVLLDIVQPDISDKKSVMSKEQKSTVLDVEGAEVPGFDGPVTAEFDGEHIPDDPRLTLDMQEQTENKFEMHLQQLNALDGRPTDDSQGIPNFAVPQGSAAIGVPIGYPVKPPKLPKIPPPPLPTMELNGNPIPDYDLKYSWLPPPGIHIESAPRTLPTTDVDIEKPYTAEEIMKTELRRATYLPQEMIDPEPLPAYNVDLDITPKLKVYNNSSYMPTAELKPQPLSNPEFSIHIPKPTLQDSSYEIDVDDPPLPNLQPLDPIDPVTTAISVNFPPINPPQSLPNRYVDPYTHDAQSVSMCTAPWMTQAEIGDSTDIPDTELFPAEAPRTVRDMLQWLAGLRNPKHHSTLTECFNKAFGGSQSDPSQLALLVNGSYVRPNDVFDILQLTTMFAGSVLNSIAPNWRAHVSSKPVQPKPSDQSDEPDCCALICQLRDYAYACHHQLEFLKAQCNRDKLSGGWENYEYGSDITSLNSPLQAFLTDDWDSDFETHLFDPCNLCLKSRVRMGFRDEDLPKISKQGSVISTILTPSCGGDDPLLTLSSYLNCLTRRTPRTTGELVSYFHNFGIELYNYDQKSLSLLGSSLSSPHADCPDWDRLGDSDLGAVRGIRGQESLITKNNSTHDNGHPRTLSTLVGCGSDPANCPPHCSPITYRAYALYSQSFAHTYLSWTVYLPDRLWESLQKLHYDLQKHLGSGKCTSLYLCSTALPLLYTHGFTPPEGQSQSTVKCYDVMSILKEIVNGKPIASLMTAMDDFLYNIREPFIFTFVALWSTALLIFANTMLYRLDVLYIRSHLIRTKASHVIDVKALLTKGRKMLSLYKDVDYFDEDPIGQLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA6</accession>
    <name>A0A061DDA6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768291.1">
        <property type="nucleotide sequence ID" value="XM_012912837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDA6"/>
    <dbReference type="GeneID" id="24564646"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300100"/>
    <dbReference type="OMA" id="QLSPICE"/>
    <dbReference type="OrthoDB" id="10386047at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600289" evidence="1">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="206" mass="23362" checksum="EAEA93C085942D91" modified="2014-09-03" version="1">MRPVVSAVLCTLWLYQLSPICEALPGNNIRDTVDAPDNTRDTVAVSSDSIRDTVDVLDDNTRDTVSVPGGSNNTVKNKREKEIGEGEYCPIPRLESINPVWDPEEIYAKHEGKLSDFDRNFYKFWKGAFATGRFGGMKLWKVVAAMGDAFLSAMDKLGILKQMEKAERENYYLFNDYEEEFDAYLDEEANAYLEKKLAEPVPVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDC7</accession>
    <name>A0A061DDC7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768346.1">
        <property type="nucleotide sequence ID" value="XM_012912892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDC7"/>
    <dbReference type="GeneID" id="24564701"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300650"/>
    <dbReference type="OMA" id="CINRFAR"/>
    <dbReference type="OrthoDB" id="364765at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="440" mass="49300" checksum="4885504C614B08CD" modified="2014-09-03" version="1">MPPNSLAECTAASYKLIANLLARGRKSLAGPNTTTFLQDLERSLPNHYWDLKTDHVSVLLFAATRSSSRAVPTIRSLCSRLSTICDNSERNELDRDFSIPLASPTLDLENLVVVASCINRFARREFDDAQLRTMVKTLQPALMHWIDDGNKCVSATTGPLLERLPPEHYAKLCTGFICVGRILHRLTSSESNTDDGGVLQKLCESHAHLLERVLKFCADELTAYKAQSPAQMRDPPIEETYEPYIGCSLAVIEELIAFGYPVGDVKVAYWKVLGELDIRCIRNAETLVRTFCMLGPAKMTCEAGSITAKKLLDVIATHDLGDLSNEQLYRTVVTCSDLEWQHRGVLDAIGDAFLQRSHQLPDLTKVVDMLQRFRTLSYHNAALLEMLVRHVHNKGTATPSQIHCVVESCVSFRKHRYNVPQRALHFNHPTLESFVQQANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF2</accession>
    <name>A0A061DDF2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glideosome associated protein with multiple membrane spans 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769525.1">
        <property type="nucleotide sequence ID" value="XM_012914071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDF2"/>
    <dbReference type="GeneID" id="24565880"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312420"/>
    <dbReference type="OMA" id="DDACWAR"/>
    <dbReference type="OrthoDB" id="396938at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021691">
        <property type="entry name" value="DUF3273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11677">
        <property type="entry name" value="DUF3273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33607" checksum="586E53EA3CF3F234" modified="2014-09-03" version="1">MMWFTTRKDHLDDGIPPSRAPSVSFNFIFNNTLRMGFGMQLLGFVGMNLVYFAYGGKGLFTYNLVGLPEASRLDEGFRSHITTFAMIYMLGSLSLLCFQVLLADDTCWARGYRSGSKILRLATFLDAFSSTMQFIFYLYISKFYTQRWFAHLNDGSSELVFFVFTRIMHAFACFLYGLACYLLEVYHDEGAGDLHAYLNGVCFVLTGCAELMVLVFQKGMLATPLLLITLAAATLWAVYFEPEVTKLNSRTMWNTKSRSSLDLRLAVKCRTTKKTLTSKVIDVTVKTRSCIYKRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDR3</accession>
    <name>A0A061DDR3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0303990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768681.1">
        <property type="nucleotide sequence ID" value="XM_012913227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDR3"/>
    <dbReference type="GeneID" id="24565036"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303990"/>
    <dbReference type="OMA" id="WIDFTHI"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047326">
        <property type="term" value="F:inositol-1,3,4,6-tetrakisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF51">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="395" mass="44022" checksum="882B2826B3DE45D4" modified="2014-09-03" version="1">MENPQNTDRHELELFDRRHKKLSGTSLVLCDHDYRFVYKIIPEYTTSEATFYCLINGYPAHGNTVLYECLKGALKSPGRLAQMGVLPAFSGVVKVVEEEYDASENEDANDHCSIVKYFEGEGIPGVQKTVFTSIKLENLLHGYEKPAVIDIKLGIHNKLDNEPYGGVDLATRAACVKRWQDLKTSYKLGHTSTSSTKRLYNISAEDLGLGAPFTDMEPTEFHSLLKSWRQKLVASQTPEDELGFRICSICIAKDDGMLEVSASQAKLLTTEDTTNILHMYVVTKHVDMLSRALGSIPEVRQRVIDALIGIRDWVAMQDLLSFAATSLLITYDQSAPTRCRVKWVDFTHVESIRHSRFPVLPGPSSMIKGIEGLIALCESMDAGRQNVNQAVASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDT0</accession>
    <name>A0A061DDT0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0401560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769850.1">
        <property type="nucleotide sequence ID" value="XM_012914396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDT0"/>
    <dbReference type="STRING" id="5866.A0A061DDT0"/>
    <dbReference type="GeneID" id="24566205"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401560"/>
    <dbReference type="OMA" id="HALWRAC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="8">
        <location>
            <begin position="169"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="506" mass="57067" checksum="BDEC22E844D9C0E5" modified="2014-09-03" version="1">MLTAVLENGNNVTESTGGTTLVTTPLFYVNGELHVGHAYTLVAADVIKRYEQLLGRNALLLSGTDEHGTKIEAAARAAGQTLSRYVEDMRTHYHEVLNSYNVNADVHIHTAADDHGHNVRWAFNHLLHNGDIYEGLHKGYFSPAEDAYYTAFQITNGLSPQGFEVQPVAEKAYFFRLSKYQDALRQLIGTDGFLTPKERRNEALSLLKGDLPDVAITRSNTRWGVPLDLPGFEDHTIYVWFDALMAYALRSRGGKHHDNTIMVFGKDILRFIALLWPALLMSLDMPLPRQMICHGWLTCSGEKISKSKGEKVLALPTLGTADVSRFVLMSLGAFGEDFNFDSTRVEQLSELVKDKYANLTHRITGLMNNRGVYQLDRNEATQMDPLVKQLLDGWGVLRQTMQHYRIDLYISELNRLAAEINSYITRNQLWGVQSEGDFRRHCLVLCRALLVLTVYLYPIMPNIARMNMERLQPHIKEVPVGIGAASDILQTLAQVDFNPRHLAPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDV6</accession>
    <name>A0A061DDV6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768796.1">
        <property type="nucleotide sequence ID" value="XM_012913342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565151"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305130"/>
    <dbReference type="OrthoDB" id="367094at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1620"/>
            <end position="1642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1683" mass="190536" checksum="BCEEC49E4000AC40" modified="2014-09-03" version="1">MAPRFKKLTDCPENLREAIDWLIQVRHGGDGNGLEQLAKALKKLIAEAIERTYTSFCDNLCTILDPAGQRYECCREKIQSIKALKAEVDKAGIVEEDKLEILLNYVKTLKDGCVTNHRVDTSTDKALEDVQSRMENLEGLRKNLSGFTSDPSPILEQLCTGLETFLGFDPSSKGYNGNGIVYSDLDRLCDGMIAFLHGVLKGVHDNKNLSPYKEKLHDSVIDLDAQLSKGERGLNVVIDHVKSGIQGWLGAVKSSNYEVTRHINDLITEGQNIPKLLKELQDIKGKEYFEGVYSDWIYGVDLLPGIAEQSFNKLKTLDGKLSELLLPHIELIKRFVESYQDSFSRDVYGLIDYCSRVDNEFRTLDDTFEKGLSETNHGGLRYKLNDNITQLKDKVEKEYPRQLRISIEAAKHTLLEAKLVADAYLTAVYNNNERDMFRVKFDAIEGLLKEVNDKSSMPSKNKSQLRQLVTTVQQNLRQLNVELNKCASDIGRTISTAVSDITVALVQLDNKVKDDLVLLKNKIDGPIQEYFQTVDAGLKNAVKVSYSHSDFPQEFRIGIGGGKGDAKAPKLHKWAEDNNTRLQNALYKLDISGELPKFKTFVQEFIEIVDENQKTFFGAIGAEITGIVKKIVFNLYNANNDNIVVQNLMVNYIKWVTSAGDSTSLHSKIKKITTDLKNIFADGIVNEHSTFNTEVGGALNTYNVIKERANISVEELFEKIGKLEELPEAVKRARLSVDKFIKDIRKYYEALNTEVKIAISTLDHSLHKLDAMIRQVNFGIDDVHTKAKEYIQEFHDIYFRSSLNAKKNIKKEALSKFAESKEFALNKLKGLISERLKRINVIIEKDSVTGIKGMMKWMSGDLDASGRRSAENFLSKMKTELEKGDHITLLDLSKIARDFIDVILIYAGGDVKKVFTHDCMIMYRSKVKSIFDKFSRLLDTLTHYNADFSTNLAEFQNLLSDLNPHEFDVPAYPVLDILRVGLLKLCKELEKAYVNSYSGRAINWNRNDNTDKGNCAKVCLTSIHMLFNGLHEMFYKCARSYKAFAIDGSATTDENRYDLAKYLQLQGFNVDRLYKNKTGWDVAVKLGKGFNNNGGFSNPEETRKRFDVYMGAALEMEAPLSVLFRNLQAYCRVSHHNIATSTRYPSSIYEMLGWLAGLPYNPIFRKLEENCKSYYDVEKERHMVSKMHGLMAYDLTTVCDYSYNLLTRIAGFGDAATYYGCEYMNNSLNLHYMEKPSQCFDMLLDILRRLFHALRFLHVHCSIDKSSYGWGECRFGTGVQASDWHCSQYNDKLASGTADCSISSPLQLYFTDGLRGMLPHSIVSENQKLTCATCTKTPPSMPCLTPLGFRSFSGTTRVGKDLCDVLDKLCGDNGVFTTVYSNLSCLISRPPQSLPDIFCFFSHLTQSWKTMPETGFPSGDKSVQKSVCDKIVGTVACDYNDARKLLDSCRELYRSKSHNKHDYEKSPDIEYLIGCNKNGCGYLIQMLNGPAYSDLSAKHANKYLSWLTYICPSIVTFLEQLKNAYCNISCFESGCQGCHHEGKCLSGKHGTEECGCTSMVHCRGVLPVFYRYGLTYADASYKSKKRCYIFCKALDRILNSELLNNFLTAVDTFLWTIRKYFFYTLLSLWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARLGKLAKLTYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDY6</accession>
    <name>A0A061DDY6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylcholine:ceramide cholinephosphotransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0306040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768886.1">
        <property type="nucleotide sequence ID" value="XM_012913432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDY6"/>
    <dbReference type="STRING" id="5866.A0A061DDY6"/>
    <dbReference type="GeneID" id="24565241"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306040"/>
    <dbReference type="OMA" id="IVACKYH"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01610">
        <property type="entry name" value="PAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="11">
        <location>
            <begin position="242"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="445" mass="50306" checksum="2A11F92AC0A20120" modified="2014-09-03" version="1">MYVSGDSGSVVGSPLSRCTSQKEDDSVAWASPLPLAPESSGSESVNSSRSNYRNDKCLDLESVDEAYVESVIKECQSVVRGMMWRLFYAVCIFFVVLIFQAICVWNSDRVYTKYTTSIDPPPLYEWQKRSFNMSPLYDHLQVAFMSWYGNTQVSIRCADVLIAVLCILVCGKVLFSAPLMFGCQMVIRYVLLMSQVYLLRGVFIAATVVPTPAQECKVFDQNANFLAQIAHVVQGYFSITDTCTDLIISGHTAGSTLFMEMFVMHNNMWHLNTAVVIIVMLIYVMLIVARAHYTIDVMFGVLLALHLYVHHLRIVSRVGRSTCKGIKLGNSFFSAICRAFSRFEMVEERIQLYVRLRHLKETTDDQVWHANKLAFYYNIFGIEDNVEPTCIYKGFDGWSKANFRLIGRAFARSKEPTPAPVPKPAEGPDTRRAPPDDTPTTNNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE12</accession>
    <name>A0A061DE12_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L33, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0403520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770050.1">
        <property type="nucleotide sequence ID" value="XM_012914596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE12"/>
    <dbReference type="STRING" id="5866.A0A061DE12"/>
    <dbReference type="GeneID" id="24566405"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403520"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_bL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001764">
        <property type="entry name" value="PRK00504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001860">
        <property type="entry name" value="PRK00595.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L33, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595745" evidence="4">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="107" mass="12252" checksum="43B966C92612D77C" modified="2014-09-03" version="1">MGVLGHLYACISILLLAALSSATCFNPLSPGARQNAYDRPTTRFEIGAKRRKSARVLITLECTEARKLGLQPSRYYTSKNKANTPERLELMKYNKYLRRHTLHKEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE25</accession>
    <name>A0A061DE25_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0403920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770090.1">
        <property type="nucleotide sequence ID" value="XM_012914636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE25"/>
    <dbReference type="STRING" id="5866.A0A061DE25"/>
    <dbReference type="GeneID" id="24566445"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403920"/>
    <dbReference type="OMA" id="TRIFMGT"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="325"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="545"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="761" mass="85102" checksum="D52811081C23572E" modified="2014-09-03" version="1">MSQHRRHDHSRPAASETSKSRNHGKPWVRRHKHQKTSNETPNVPDAADVWQPAPKAGQPFAKAMCPPFGMMPPIMPKQGVGMPRGAPVMFPFMDPAMYQNMMKSMAAKAAGKTGEELDMKALMATLPPAAKMPFPLPKNMPVMGMPPPGMIFPGPFMGMPKKAPFPGVMPFVPDPAFSPKAAGPSPVRAQQTEPTSGHTQADNGRHHHSASSKYLSLSQVSRGGRSKRSRAHLDEGSENISVISDEDYRNSHDGAKDALRGATASGNASPNIAFVNSFVPSPPERYRRDYQLHEVKMFSALGIRAQAKAKKLSPEVRASFESGPVKNGKLVLLLDLDNTLLHACSQSKLGMLDIQLSHFVDELGEPELYKFTMPNFANVRYYMKLRPALRGFLQVLSLYYEMSIYTNATKEYADVVVAILDPDRSLFMDRIVARTSVGERDLQKTAARLYPDLDTRFVVAFDDRTDVWADVPYNQVVKAEHYDFFDSHIAELSDSYGIVSPNSEGSYYSDSDRHLEYMVKVFLELHRRFFNDPFEASVGDILEDMQRSVLEGVGIMLTGYRKNSKGQGQVLQADCEQKQREIATQLGAKICTRLSDKKLTHVVAGKNCTDNIVKSKEPCYSHVHKVHTLWLYSCRATWTNVPPEKFNVDDICEAYSNEPPSQPCKDHWKILLSDDDDSDKRATSDNATEDQLPTRIFMGTGSYSHGTELISPTERVVIRWDSAKTKLLQNNTTDPIEQKSVKQIILENAPYTNSVNPERYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE80</accession>
    <name>A0A061DE80_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0308090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769091.1">
        <property type="nucleotide sequence ID" value="XM_012913637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE80"/>
    <dbReference type="STRING" id="5866.A0A061DE80"/>
    <dbReference type="GeneID" id="24565446"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308090"/>
    <dbReference type="OMA" id="RFASRHD"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="11">
        <location>
            <begin position="704"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="744"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="423"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="549"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="870" mass="85641" checksum="C4278C93419765A7" modified="2014-09-03" version="1">MQNDNKNIFGSSNVFGNTNPAGTTGTPGTGLFGNTGAANTTNTTGTGLFGNTTTTNTTGTTGTGLFGSTGTTGAAGTTGTGLFGNMGTTNTTGTPGTGLFGGTNTTNTTGTQGTALFGSTNTTGTPGTNIFGSTTGTGSLFGNTGAAAGTTGANIFGSASNASGNLFGANTTGNTGPSTNIFGTNTAGTTPTNSNIFGTNTAVTTPTNTNIFGANSAGSTTPPSTNIFGSTTNTGGSLFGNTSTTAPATAGTTTGGATTNIFGSGNTTGSNLFGNSSTAPTTGTTIFGSTNTGSTTGTSLFGAAQPATTTTTTTTTPIFGAASNSTASGSGVTAPAATTAPATSLFGSTQPASGSTTTTNVFAPQGSGSTTTGTSLFGSSGTTGSTTTPSSSTTNVFAPSSTSSATPSGKPGTAASGTSATPSLFGTTGSSSLFGNSGSSTTQGTTGTSTLFGNTGTSTAPATTGTSTIFGSSGTSTTPSTTGTSSSLFGNSGSTTTPATTSTPSLFGTSGSSTTPGTTTTFGASTSTTTTGDSGASKSVESTAPTLFGSTTTSSTQATPSTTSTTTIFGKTTDTTTTTTASGTAGTTTSSTTPASGSTTTGTTSSTNLFGTSTASGTANATTPSTTGGLFGSAATTKGSQADSKSGTAESTSKPATTEPPKFTFGASTTTSATTPAGTSAAPKEDEKDKEKFELDFSVTEQHNVMELLDSWESRLSKKIVSFKEFADKVAGIDRNLVLQSSKLNKLLNEYKGLIEKHENMESAIKQMEEEQTASINILDAMERSLQSQLENVRNRSANYNTVQSMTRQLQELSEQLSHANKEAENTAIACQPEPLYTVAKVLSFHEASIVNLERQCYDIERRINDIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE94</accession>
    <name>A0A061DE94_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769131.1">
        <property type="nucleotide sequence ID" value="XM_012913677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE94"/>
    <dbReference type="GeneID" id="24565486"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308490"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="51" mass="5074" checksum="CFD22F8F7DF943F7" modified="2014-09-03" version="1">MEKLQSVPTGGVAAAPAGGAAPAAGDAPAESKKAEPEPEEEEDDMGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEC5</accession>
    <name>A0A061DEC5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769226.1">
        <property type="nucleotide sequence ID" value="XM_012913772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEC5"/>
    <dbReference type="GeneID" id="24565581"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309430"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="135" mass="15721" checksum="A6E9FBDF8A5824E8" modified="2014-09-03" version="1">MKLALNKLRGALQVAFIWHEKRSRRVVYTTFLGLEGFIEIDMETGMEGMVDKLTTRPSYRDNKFMRPKTDEVLWGLFSKRFRDLYMSVGNLDGIGGLYNRLKETPKRPHWLTPFNLPIITRCAVDIIPEHFTGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEK4</accession>
    <name>A0A061DEK4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769621.1">
        <property type="nucleotide sequence ID" value="XM_012914167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEK4"/>
    <dbReference type="GeneID" id="24565976"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313370"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="80" mass="9279" checksum="7369CD354E61D1AD" modified="2014-09-03" version="1">MSLPCRPEYCQKACKIKNGRCECGCCDGENIDHVVIVSLPIIVFILFLLAVCIMSFFRIRPFHKVRDFCTGRMNSFHRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DER7</accession>
    <name>A0A061DER7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769936.1">
        <property type="nucleotide sequence ID" value="XM_012914482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DER7"/>
    <dbReference type="GeneID" id="24566291"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402380"/>
    <dbReference type="OrthoDB" id="366460at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600842" evidence="2">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="170" mass="18862" checksum="2666B92534880EDE" modified="2014-09-03" version="1">MHITASVLIFWFVALCNRCEVDGARSLESSAAVSGAASSVKAAQRAASRDDDDIDEDDIDDDEGREEADDDDVGQELDDAEDRYRATLCVAFLLRFERNEKTLEDAEDSGLKEDLEEEASEEAYARAKAESGEGNKEPEDAAKARIRRLMDDLVAASLELREINRELDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ00</accession>
    <name>A0A061CZ00_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766032.1">
        <property type="nucleotide sequence ID" value="XM_012910578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ00"/>
    <dbReference type="GeneID" id="24562387"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101750"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10744" checksum="8199306D99D2736C" modified="2014-09-03" version="1">MQGCGVTYELDELFKPETPNCFYQVSVNGEVKDLGELSESMFTTRSNHFIILKFDSDNIGPGEELRQTPPLECRCTTVKRIVLSTIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZA9</accession>
    <name>A0A061CZA9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766147.1">
        <property type="nucleotide sequence ID" value="XM_012910693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZA9"/>
    <dbReference type="GeneID" id="24562502"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102850"/>
    <dbReference type="OMA" id="GICETSF"/>
    <dbReference type="OrthoDB" id="441724at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595287" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55842" checksum="FAEC5415F08288C4" modified="2014-09-03" version="1">MRLRIAVVRWLLSVVAVSEWTSFAFADADVPVDLGASNDALKLDYLPNLGYRLKLHVGAQALSLKLVSTLEGIVLFEKGTSACPRTATESQCYDSKSSETATWCYNGDVCVPGKSDFKCHEVKSHEYIVTTTTTDFSADGVSHSMQTIEGFEKVSFSDAELPDPATFQRVPVKLANKVVAGSHMPVNAEAGGFFGIAGGSMGCRQQSIWDELLVKYHGLYVIDLNGDAAGHGGTASAGSQIKLGHDSVNADDVLWGERRQVGGIFTDASIEFTAHGMSMCGVNLFGRTSGYWQVAVDVASQCLVLPLNFWLSLMAQLPVEEGCYDKQPPKMCAIRRGEVAKLPAIEFKLRYDSDDQVVRIPLQHLLLDNGGSPLLCVVPDEDTPSPLLFTNRPSIKLGYKVLESLQVVVDTKGHRVGFVHKRPVETSNEICVPPVQCVGDQTYLPELNYCLQPSCRIWAFKWLDPATGRCYTPVVLTTLMYLVIASLFVAQCGSFIVRRRVMRRARRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZF8</accession>
    <name>A0A061CZF8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766197.1">
        <property type="nucleotide sequence ID" value="XM_012910743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZF8"/>
    <dbReference type="STRING" id="5866.A0A061CZF8"/>
    <dbReference type="GeneID" id="24562552"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103300"/>
    <dbReference type="OMA" id="VLEWLFK"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="603" mass="65956" checksum="05AE0441656FC71F" modified="2014-09-03" version="1">MIGEVLRLSISSKNFNSYVIGSARAHFRRGIPCNGSESGRHYHANRVSSVLRGSAFSECKDGTPAVVNLRSCTIKDMLLTTRREESSSSALTAGSEGTRCERVTKAVDALPAASISSCGYPLARMTGMHPSKRPALNDALRLRHAYSFATHAAAADNVECGPGITALCSKIEELLRVKSEQLVTLRKEFGKVTVGEITVSQVLGGMRDIIGMNCETSLLDANRGITYRGLTIAELLEKLPGATEGNNCPYSEGVMWLLLTGKIPAASETKTLSAELGRRAYVPMHVFKVIDQLPTDVHPMTQYVAAVAALQSESKFRKVYNEKKYCKETAWRLVLDDSLNLIAANPLIVGYIYRRTFVDHTIKDGKGMTYDPELDYAANLAKLIGIDTPEFRDMMRLYIAVHADHEGGNVSAHTAHLIGSALADPYFCFAGALTGLSGPLHGLANQECLSWVNNMVKEMRGQEINVETVTKFAKDTLAKGQVIPGYGHAVLRVEDPRHTAFVKFAHKHFPDDPLVKILDVCLEAIPPVLMATGKIKSPHPNVDCSTGIILSHFGIKEPDMYTVFFGISRAIGILAQLVWARALKMPIERPKSHTLDSLLEMCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D017</accession>
    <name>A0A061D017_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit of proteaseome activator complex, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0104950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766372.1">
        <property type="nucleotide sequence ID" value="XM_012910918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D017"/>
    <dbReference type="STRING" id="5866.A0A061D017"/>
    <dbReference type="GeneID" id="24562727"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104950"/>
    <dbReference type="OMA" id="KKPPKCG"/>
    <dbReference type="OrthoDB" id="6591885at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.180:FF:000002">
        <property type="entry name" value="Proteasome activator complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="3">
        <location>
            <begin position="98"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="235" mass="27234" checksum="527F20EC04419D66" modified="2014-09-03" version="1">MDNRINGLSVDPVDSAVKEQHIAFKEEVTRLALDSLRERIPRKILHFSKLVKEKASASGLFHSRDLDSVTYRVSAVDESASKRQKRSVEEEDSRIITPSHKQILDELEAIKAEASELIEIIGNIKLWIQLNVPRIEDGNNFGVGIQEEVILELTRVEDTAFNLFDSILCTKVIKYPNVCDYTEAIRELDEKEWIHIKITNVDMRNNYSMIYDLLCKNWEKVVKPKSENNHYRMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D090</accession>
    <name>A0A061D090_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0105550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766432.1">
        <property type="nucleotide sequence ID" value="XM_012910978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D090"/>
    <dbReference type="STRING" id="5866.A0A061D090"/>
    <dbReference type="GeneID" id="24562787"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105550"/>
    <dbReference type="OMA" id="MMNQRLW"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="349"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="734" mass="84768" checksum="4FE87C0C09CF80A7" modified="2014-09-03" version="1">MEESMDIIMPSEGLDCSRVVKDVSSFQLKKDPDFIQTRLITFDTLYERQKKRIDEIEKRDISVNLEVSGKEDEMINCKSWVTCPADLLSRLNKADSKAIIVAEPIMGTVADIENDDEQNEEWIMWDLFRPLEGDCKLRFHSFDSPKGQHVFWHSSAHMLGSALETLYGAYITIGPALSSGFYYDCYIGSNSFKPEDMEHIRNEVSKMAKVKSPFQRLVCTKEEALELMKHNPFKVDLIRRKVPDGSNTVCYRCGNFVDLCRGPHLPYTSSVSPKAFAVTKFSSCYWLSKSTADTLQRVYGISFPKEEQLKAYERRIEEAKYRDHRIIGTKLNLFHFDNIHSPGSCFWLPNGAKIYNRLVDFMRENYRLRGYQEVITPNIYSCELWKTSGHYDNYKENMYMFNVDETEWGIKGMNCPGHCLMFRYLSPSYRQLPLRFADFGVLHRNELTGSLSGLTRVRRFQQDDAHIFCTTEQISGEVLSILQFIDDVYSLFNFKYSFKLSTKPQKALGDDELWEKAESGLRDALERCGRPWTLNPGDGAFYGPKIDVILLDCLDREHQCGTIQLDFNLPIRFNLGYRDKEDGESTDCKRGFSRPVIIHRAIFGSLERFIAIVIEHLKGKLPFWLSPTQVAILPISDKHMPYANSIYERLLHLGYNCYVDGSANTMNKKIKSNQDQRYNYMLIIGDREVETGTVSMRSMDSQANETLSLDALYARLATEADAYKKNIKCFHLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0P0</accession>
    <name>A0A061D0P0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766404.1">
        <property type="nucleotide sequence ID" value="XM_012910950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0P0"/>
    <dbReference type="GeneID" id="24562759"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105270"/>
    <dbReference type="OMA" id="NEATCIT"/>
    <dbReference type="OrthoDB" id="361288at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="303" mass="34923" checksum="98ADADC9E8989344" modified="2014-09-03" version="1">MRRSEGIRVELIKDISFVADTELLNRYGIPIPPRSPQGSLNGVQDTYALVKHVLRRYEGMLVDTVERATNVKFDKRKTMLIKLIGAVTIRWHTIYRWKTCDRAILRSLTVGNKDPMIYEQRCDNLHVYQLLWQEHCSAMKHLLEEWSEARSIGVQYALSDSSHDNTEITDVMDRINRLIRGTVSEVQSVTVESVRATMTLDHLLNKNYVDEAVQVTFDTRGVGNLKRQKINNLQMTINLGISNFEKILGTVSLQLNSLVRFSRLMSHKLFKKAKPLEYVTLLKVIRKAICNTMCRTHPTTTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0U8</accession>
    <name>A0A061D0U8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM-dependent methyltransferase RsmB-F/NOP2-type catalytic core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766617.1">
        <property type="nucleotide sequence ID" value="XM_012911163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0U8"/>
    <dbReference type="STRING" id="5866.A0A061D0U8"/>
    <dbReference type="GeneID" id="24562972"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107355"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107355"/>
    <dbReference type="OMA" id="RHIIHAH"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase RsmB-F/NOP2-type catalytic core" evidence="1">
        <location>
            <begin position="232"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="41954" checksum="DF3E380DD73D9396" modified="2014-09-03" version="1">MYTSAFDSHYADLYGKRWAALSRCLRRAPTAVAVIPPFFEQIPDQSELDQCSAPEVSVEDLQGSSYYRRTVLPFCYEQRTFDSRTKSDPSPSELTLYAKKAIFNANNFVVKAEDCVYYMDVGLCFACHCLGVAPGDRVFDMFAHGGGHSLIFASLMFSQGESHTGISGEGRSTLEMVELINQAREAKQRYAETSLLVCGETRRSVHQTTEDILKKYLPKRLLDAASVQTVHHHADHQKIRRYGLFDRIFVRVPQSADTADPNTWSKRGLKASSARALGALNCAAKLLKPGGTIVYCSHSLDPMENELIVHTVLASIPELRSEPIDAQSLTDQLRTSLAWETELPSALPTSETRKYGCAFMPDTSPCGPLYICKLVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D137</accession>
    <name>A0A061D137_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0106470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766524.1">
        <property type="nucleotide sequence ID" value="XM_012911070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D137"/>
    <dbReference type="STRING" id="5866.A0A061D137"/>
    <dbReference type="GeneID" id="24562879"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106470"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="338" mass="38036" checksum="2BC43BB6556780AE" modified="2014-09-03" version="1">MSSYKYLFKYIIIGDTGVGKSCLLLRFTDKRFKPDHDLTIGVEFGTRLINVRGDNIKLQIWDTAGQESFRSITRSYYRGAAGALLVFDISRRSTFEHLTKWLEEVKDHGSPTMTIVLIGNKTDVNNREVEYDEGKAFADENNLIYMETSAKGDYNVEEAFLTTASLIYDNVMRGMFDIESGVYGVKKGPQANINSVRRAVNLRHNGSGTFSGQLRTRSQKMTSRMHAANANMAKSQQMRQETNTEDVFLLDLEGKIDQLKNVSTDLHSELKYSKTRVDTLRGGLDEAQGYVKDGLGNMSKLMRNKKGNVAMMKLTLLTATVLSVLYVVVKIALKRMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1C5</accession>
    <name>A0A061D1C5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0102410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766098.1">
        <property type="nucleotide sequence ID" value="XM_012910644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1C5"/>
    <dbReference type="STRING" id="5866.A0A061D1C5"/>
    <dbReference type="GeneID" id="24562453"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102410"/>
    <dbReference type="OMA" id="CGWSLDF"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="327"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="998" mass="108994" checksum="F8224F6347ABD366" modified="2014-09-03" version="1">MASLLAEPLICGSLLATKVTLRFPLSIFGTSDAHSANGIVKFETPDSAVASSAKGRPQRSSRSTRKTLTSADTNANFSGASTGDSSSEEAPKEQFAEVHVLVNCGWSLDFDQESIALLKLHAKDVDVIAITDGDFEHVGALPVIYSWLHGIRGAAGMPPVLCTEGSYKFARACLVDVLENATFSYKFDDFGMSDLDFLYSGCCKLRYHESYHLTKSTYDWTVHVAFLPLNNGVSIGGAVWKLSVGPRSIVCCPTYRVQPSWYLNGCEIGSLDRADIFLTHEQPKLVEGPQSPQPSECKNMEAILSVVAGTLRSNGSVLIPMDVGPHIIDLLLHLNSVWANSDLQQFPIVVVSPIAVKMVLLFATCLEYMQSDICHNFLRTMWNPIFNLNYIHPVSTLEELRRFSSMPCVFISTCSSLSFGVTSYLFAALCCYERNTVIFTRDSPEVSALMGQYRATGARDAMAGLQHEFTLRLNLEPPDETDAVDMGRFESGSREHKMCIEHADEAYNPAGAAAVGTGDVAMDAFGDELATEFLFKNSRNFTVHNGYVSYMPPAILRDDLESSNKPGDRDLDYGIPYTSVAAAELDQNIAPSAAAAVYVEEPEERAHKPDAFSELEQNPFNAYYMQHVENSAVGAIMFECSGDYGSGSEVQSSAAVSKLVVKRLPLVIKSGLYITHHFRHFHPRCELVSLLSKICPRNIALLPRKNDVGAVACAEMTIRGAIPSCGALHSFDSAAPCKHETGLLSQESLHRQLCIPLDVRQEYVNRSGTLLAAGHLIKEFHGVRVTPANKRAEGGSRMERLMAVLSSIDAWKRHNNPRQVYQAIVRFDCFAGESSSGAEGVLLCSSFWSKRPPQPPRLAICLPGDPTSTTSGGAEGGSAEYSGAAEDQDSMDDGSARAASSPQPLSDEPYAAISHSLRHSVYTGSVGMPTLVRYFEECLPECCTVGSGALNINGNVQISRSDVGYGVQRWEVRGTLDPAFYFARKMLRKLHNRIEPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1F7</accession>
    <name>A0A061D1F7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clathrin coat adaptor subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0107710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766659.1">
        <property type="nucleotide sequence ID" value="XM_012911205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1F7"/>
    <dbReference type="STRING" id="5866.A0A061D1F7"/>
    <dbReference type="GeneID" id="24563014"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107710"/>
    <dbReference type="OMA" id="VDIAKFH"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="204"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="478" mass="53757" checksum="61EF4D9B958FEDEA" modified="2014-09-03" version="1">MISAVFISNCHGSLLFYRAFRGGSSRQDAVMYAKNMIQRSLKPYRPIQQFGFATYVRVKLDALHLVASCDGDVNAALVMQCLVDIRDSIVTLLEAKVTAAEITRYATTLQEMVDLAIDGGFPQDFYMHYLGSWTVKDMTTNLFKKNQPKISHYLEGYGVDYGKYMKAQKMVFHSEKDLVATSDPEMQMQNITVPWRVASSTTRKNEITLFISECINCCYSHVGELLLSEVTGSITMDCSMPGTPKVAITLNTDFANSHERITYASVENKNESHFPLPSGAKVATTMQDFKVHKTVDILRMLRSKQITAVPPQGMTALMLYRCDVSGELPFHLKPVITRATRYLLYYHITIRTKFPKTVTANNVFLKIPLPATTSNVEIINHFGHCQFNLAGSSMHWHLVKTGGGMKYTLEFQCKLARSVSEQDPAIGPIEVEFVLPNFSFSGLFVRDIEVTNTAHKAHKAVQYNSSNGSYQHKLKFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1N7</accession>
    <name>A0A061D1N7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">METALLOPROTEASE 1-RELATED protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0108610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766749.1">
        <property type="nucleotide sequence ID" value="XM_012911295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1N7"/>
    <dbReference type="STRING" id="5866.A0A061D1N7"/>
    <dbReference type="MEROPS" id="M16.A12"/>
    <dbReference type="GeneID" id="24563104"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108610"/>
    <dbReference type="OMA" id="WEGFARI"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="70"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="211"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130121" checksum="D44662E7D877CEE3" modified="2014-09-03" version="1">MTKFNLEGSDHASRVKNVIIQGFALVNLITVKHVEVSEYVSERTGLRVFFMHYESPIVNSYFIVPTRAESHEGLPHTLEHLIFLGSASYPERGTLDLLASRALAAGTNAWTDVDHTVYTISTAGVDGTLMMLPVYLDHLLRPTLTQEAFMTDVHRITPDGSNSGTVYSEMKDNEHDADSVTEFELNQLLYPGGSGYSMSFGGRLESLRSTNVERVREYHKRYYRLDNMSIAIGGSLNDGERILQAVSKAEEALLAAGVEANAVKSAYYFGIKQWDDPVHCQPLKETVEKTVYFPSDDEELGQFTMAWRGPAWSDFQEIRALSIMGLYLTQTPISPMEKELVYTRDPFGSGVGFAMDEYKETRLNITVLDVPCGEKMEQIAQKMRDIITSVWESPLDMERLQAIIRRERLSYFRSLETQASNIMIEGIVSYVVYGEKRKDLDEQLEGDDQMGRLLLEDEPFWKGILEKYLIHAPWVGIRTVPSIKESKRIEREERQLVREQLKKSDMKLLEAQEALVNSIVSNKGGGVPKHVLDAFGVAAVENVALPQWPYMRNFNSVGPDADGGRAMTGRVQLFNVHGHRTVEHIWSDLTRQLDEVKISMQVNHVTSDFVRFTVLIPTMDLGLTHLEKQCLTLLTNLLFQSHLREGRGPPMSSDAFIMELQETTSSYSASLGLASSFGSADAYSEMVRISLTCHIGLYERVFGILQRVLQDVQFTDDIVDAKVKSLLKSFHEKSRSAKANMRQAVQAMRMKRDSVRMSNGIAQQLALLRDAEEGETAALLQSLYDKVFAQRNIVAHVTCDVRFMPKSWLGLWAQLPASGATGDNLRDMIGFKFATDVELSDQRTMYMSMASTDVSFFNHAIRAPIGFGHSEYAPLSMLCEYLCMLESPLFRAIRGGGYAYDYAVSYLPSVGEMHLSLLQAVDVVGALRATRDVFGLIRRGNLPTEDDVISARCSLVFNIVQSEESLSAYSCQTFQDAFRGVDSKFTVTLLNSIRDVTPADFRRLAETYLSHFLHFDDPWSTAAVVTNKSQADDIYHGLVDLGYDRLRRVSTKAMMNFATTGSLESADADSDDEMGNDIDNDGDDEMPHPSASRESDGSDDYSELEYDGEIYDSRDDEDDDDGDDDDEEEDESLSGDEGDDAGEADEGGDEGNMGNYNYFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D245</accession>
    <name>A0A061D245_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0111090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766997.1">
        <property type="nucleotide sequence ID" value="XM_012911543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D245"/>
    <dbReference type="STRING" id="5866.A0A061D245"/>
    <dbReference type="GeneID" id="24563352"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111090"/>
    <dbReference type="OMA" id="ESSWYEV"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="420" mass="48241" checksum="576403F872062BF9" modified="2014-09-03" version="1">MSDTLHTSAPKGWTISAFPSSGTAWVRPSGRSGVRSAKLLRYRVETSTKKVYYYNRASKESRWQRPDVDAPESPKEATSPAPEPEEPAPKSTSKEDIAGFKALIRELNLAPSATFDSALPRMLYDTRFTAIPNHQRRSLFMQLRLELVKESSRSLKELSKEYIANERSAKFAPAAGSTQGSKEVQPENRPAAEDSSTCNQTDRKHASSGTYQRERDSGKRRHTEHAQSREQLATDMARTAFISMLHEKIKMPFYNGKPEPLDEALIEGDPRGESRHLKDRDRIYRQFVDDFLEARIALFEQKLQTLGNEHIKTPLDDVVHTLGERLFGHLPRDRLEASLRRWRRDAKAELLDAFDVLLRQTLCYAEGTTDSKLRLAKLQLRDDPRYQRLDCLPDERDELVLRRIRELDEIHRKSRADLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D253</accession>
    <name>A0A061D253_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing regulator WTAP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0111190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767007.1">
        <property type="nucleotide sequence ID" value="XM_012911553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D253"/>
    <dbReference type="STRING" id="5866.A0A061D253"/>
    <dbReference type="GeneID" id="24563362"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111190"/>
    <dbReference type="OMA" id="HIQPLFI"/>
    <dbReference type="OrthoDB" id="366255at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING REGULATOR WTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217">
        <property type="entry name" value="WILMS' TUMOR 1-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="361" mass="42050" checksum="B697BC663D35ACF6" modified="2014-09-03" version="1">MATGKSLDDIVSGVAKLKDVASVKAYFMAVLSAQQKEIQKTKALVDDFRAIHNFENLYEKTGSFTALVDPVVNCEILHLRRMLRSKDEELRARNDAIDSRYFNPQSHVGQALLKKCRMFAAENEELGRILLEGQIQPLTLDLNKERESNKVLKNQVKGLHQYNVELEAEIELLSKQLSEQAQQIATLKKENDAMAVKVRSSHAAADSSPARKRSSQSPRRRVRDEKTHKSDRDSRYDKTARDEKSAKDDRDGRDERSRRSDRHEPDRRDSKHTTSRKDDKYEVDRKADRYDAAKKSDRSDAMKRAEKYESKKDDRRISSRKDEKPRREESHGRTPVKRVREDSRSRRSPYRRRSRSPRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2M8</accession>
    <name>A0A061D2M8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767039.1">
        <property type="nucleotide sequence ID" value="XM_012911585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2M8"/>
    <dbReference type="GeneID" id="24563394"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200100"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7167" checksum="224D8719B637E4BA" modified="2014-09-03" version="1">MRLSEILSKHGEQVRLSPVHASQHKRQQIQPVSLHFLSPSRHVHSLVIFTLSSSTCTTMNHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Q9</accession>
    <name>A0A061D2Q9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767074.1">
        <property type="nucleotide sequence ID" value="XM_012911620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Q9"/>
    <dbReference type="GeneID" id="24563429"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200450"/>
    <dbReference type="OMA" id="GPFIVDI"/>
    <dbReference type="OrthoDB" id="422904at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="590"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="654" mass="75684" checksum="0F85CD8030D37D7E" modified="2014-09-03" version="1">MAFTFFLERQIPLLLAEACRTWKCTGVSFPARTVGTSATHRRLTTSAFKTSQPAPPSPSDDRYIQLQSTDDVGKVTRTQSVVDITDDNADVSGRVLSQKEFLEAKRTRFVTKEEYDQLKPHEVRKHVKATMKPADLEAKYGKKRAKKMIKRQMLAEHGKVTWNPREPVAESHIKEFSVDDIDIERRPRVEQFHFLNKSIYDMTEEEFYSSFFRDRERKFDGMGSKLRNLEAQLLKEQQEALRDSPKTRIAPKAYWMKPNYVSPTPDEVAALNSLDLRFVMMNEARKSIATCNIDDKVWEAFLTRVNTIAANVCIRSLLRFLQIVSKVQLTPTDHVRALVDHIHRRRAEMKPKHYVFLFQALGRLRLRDQRLYDDLYEMVLCWPVLRNNFLVKAANSLAKLGVCDSLLLQPLRDVMAKRIEHFSATDCTRMKAITVLEMFGDDMILSFLEKCEYHRQHFRHYTRHLEVIELYIRLFKAEVYARMDDATKQFLIDVRQQTLAKKLADATLAPIAADEPNAAIADEGEDDHSDQDVPGLRDSAADDSGTTTKTFHCPYHEDVSRVLTLIGVPHRNYMKAGPFILDVYEPKSNTVIEINTEHQYYHGTTHLTAMARRRHELIAGMGFRLLHIPYRWWRQLHGDEAKASALQEHLCLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D318</accession>
    <name>A0A061D318_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767347.1">
        <property type="nucleotide sequence ID" value="XM_012911893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D318"/>
    <dbReference type="GeneID" id="24563702"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203180"/>
    <dbReference type="OrthoDB" id="10628828at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="442" mass="47829" checksum="E526353E6709BBC6" modified="2014-09-03" version="1">MADSTTDEQSGNADTLSKGIAFYEGNEDCARQIVGLSKLHQIATDMTWELGGISVNISISKAPYDFKEAELRECCKFLEVARGVTAATKEYVYLARLLDLYRTNIAEIRELRRSPIFEAAASKALNDVAQDFESKEQFARNVLEFDVLSDYVIKIREVEEFIRRHTGRKIYPYRYTVKTPAVSSDACFVASKVGIGSDPPKSHNTGVSTDCAYEWLQTTSSGTAPDVNALSPSVTEVTDTRPNAATTEAEELTPSQASNAIELTPKSQHREPEEPTTSPGKPEVKDTVSSLSPATAFGEPTILPEPSTAFDETTIPPEPATAYETAIPSDATAFYETTIPPEPATADETTILPEPSTAFDETTIPPEPATAFDETALPPVATGQQVTAGGNEEIQSKIGGMGRYLSREAVRQSGRMHLSSDVMMRIGVTQTIVALVILAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3A7</accession>
    <name>A0A061D3A7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0202400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767269.1">
        <property type="nucleotide sequence ID" value="XM_012911815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3A7"/>
    <dbReference type="STRING" id="5866.A0A061D3A7"/>
    <dbReference type="GeneID" id="24563624"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202400"/>
    <dbReference type="OMA" id="SCYNIFN"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="62"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="358" mass="41352" checksum="D93654524817F7A5" modified="2014-09-03" version="1">MRSRKKALSPSNIPVLSLKNGPSSPPPASSSQRLHRLSSALTAPIVDIALIKQILWLGIPEDAPLTHRADAWRLVLGYLPVVTASREQQLERKRRHYQGMYKQHCDADVKCESDQKTLKQIQVDLPRTNQSLRLFKDKRVQKLMERVLYIWSVRNPASGYVQGINDLLVLFVAALSRPYMGCFSLDTDAVDRLTERDLEEIEADSFYCLSRILSHMQDNYTENQPGVYKSLNRLKDLMKRIDMKLCDHLEALGIDFMQFPFRWMNCLMIRELPLDCAIRLWDTYIAEINEGIVAFHEYVSAVFLSVWSEELLHMDYQQCLLFLQRPPTLDWGIEEVDAVISKAFVLQSAFHNSPNHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3N6</accession>
    <name>A0A061D3N6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Small GTP-binding protein sar1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0204640</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767492.1">
        <property type="nucleotide sequence ID" value="XM_012912038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3N6"/>
    <dbReference type="STRING" id="5866.A0A061D3N6"/>
    <dbReference type="GeneID" id="24563847"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204640"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR95306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="196" mass="22111" checksum="788C4BC51249C571" modified="2014-09-03" version="1">MMFIIDWIKKALISFGWLNKEGKIVFLGLDNAGKTTLLRMLKDNRLACHTPTVHPHSEQLTLGKVNVTAFDLGGHETARRVWKQYCGNVDAVCFLIDASDRTRFQESAEELRALINQEELYHKPFVILGNKIDKPSAASEEELRSHLGLLAGDTYGKDCGPGRCVRPIEVFMCSILRKQGYGEAFKWLAPFLQDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3V2</accession>
    <name>A0A061D3V2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766923.1">
        <property type="nucleotide sequence ID" value="XM_012911469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3V2"/>
    <dbReference type="GeneID" id="24563278"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110350"/>
    <dbReference type="OMA" id="YGTGRCV"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29863" checksum="FBE5DC38E3622FF2" modified="2014-09-03" version="1">MASMRESDDPGEGASATVLLKRPLFVLNKAQHEIYLTGRLPTCVYFQRALYLLRWRLSRFTELCSRQFLQDNLVNRNTGAMGNRARLPDQYGRSGSSAGDARQVAAALSKRNEAPPQGNGDCVVLYGTGRCVTRALFVLQDLYEHVKDLYVEAQSRFRRRPVRVMCADCSATWQPGPGGREKHGLNQRCAGCDAATNRALEVIVKRILQVDISTGSVACCDDVYSYASRGSSLQTPGQFCPMNSTDAVVTVTQRERMISSIRIAIRVACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3W7</accession>
    <name>A0A061D3W7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">cAMP-specific phosphodiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765860.1">
        <property type="nucleotide sequence ID" value="XM_012910406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3W7"/>
    <dbReference type="STRING" id="5866.A0A061D3W7"/>
    <dbReference type="GeneID" id="24562215"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100030"/>
    <dbReference type="OMA" id="HIPEPCI"/>
    <dbReference type="OrthoDB" id="74705at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="77"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="340"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="525" mass="57282" checksum="24335EE0450A5C17" modified="2014-09-03" version="1">MEGLKGVLHTNSFDRQSSLGGSLQHSERSDTHTDSRMLRKQGSLSNTLVQRYDLSSLTKDQLLVLMCFSNAIMSQSLPVKCILMTLKALKTNLGAELVEMCYPDKESGEWVGHSVGKDGVLHKKSIRTPESGAYYHAFTSGTHVCIDSCADNPIYDRQFDQHTDIELRNLLVCPLVDSKKLVWGVAGIANCPKLGLGSTNYHMQYSISTPVSELVSDGRQNSESNAAASSLSANSISTQNSLSVSNSTSHDDMRALSDVSSMSKEEQGDHVGVDGLQSANVVDGVDALWDDSTITFALQVCDIGGQCISNAIGWRQLDATRDKANGLLTLMHSLFADRLGIQSCVVALTTHARKLIQAERCTVYIVDRSHDQLWSISSDDGSQVIVPLSRGCASECVTSGDVIVIENAFEDERFKPEFDSRDGVEIRNVAWVPIKSGDCNRVLAVIEVINKQADELLHFGEDDLRLLEIFSAIVGPQLEKSDFAVSVSKPAETEAGLAFKTHPQSMVCASRQHIPEPCIPETEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D498</accession>
    <name>A0A061D498_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767752.1">
        <property type="nucleotide sequence ID" value="XM_012912298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D498"/>
    <dbReference type="GeneID" id="24564107"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207240"/>
    <dbReference type="OMA" id="KSWYETI"/>
    <dbReference type="OrthoDB" id="366337at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="339" mass="37526" checksum="F3E77D09679CAEF6" modified="2014-09-03" version="1">MSEGSSSSTADESRHHKGFDSGVFSSVAPMAIERNGPASISTLKMTKSDSNSGGVGSRTFASMCKWSWLPSLIFFTFGIFCMSAALLTDRWAGIRIDYKSGPAVGRSHTMLGFKDLKRLDFFHIFDATMMLSRTLPYTTIINDSYCAEDINGVSKVELDDYPAVLRRIDQVGLLDHDKEVEFIAKHGRVIYDVLCSSIPKLAHDGYVLLTLLPMSFILYFPLIIMCLLRNIFDKTSTPKSWYETIEIVAIITWVISLVLGAIGLTYYWVSVSNPLCVNGFGELTGCVVHSSVVLTLLYVLSSFISLVSYVFYGISVKKGAGHGAVRWTMSGFRRDTEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4B4</accession>
    <name>A0A061D4B4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767767.1">
        <property type="nucleotide sequence ID" value="XM_012912313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4B4"/>
    <dbReference type="GeneID" id="24564122"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207360"/>
    <dbReference type="OMA" id="ATWHRNT"/>
    <dbReference type="OrthoDB" id="366254at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25716" checksum="0E32CAA36F50EF2B" modified="2014-09-03" version="1">MARDRLWLSDVAEGVPATWYRSTFSAYVPTRREVETGVRSIPTQLVHPDGSFSVGVDVESIDPQKHGASRLQNGTVPVPCEPTHAATDEEEEEEYSLVVYASGREARKRAVAQDHPLILLSCTVYAVMVLWLGPFATLSPDATERTTTLLWLCWFSVLDVVALMCVLWYFGYFELLSINTALLACVLAVLLPHIESVYSVALAFAHVLTLLLTYYSLSKCEHRMFVIPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4E1</accession>
    <name>A0A061D4E1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765980.1">
        <property type="nucleotide sequence ID" value="XM_012910526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4E1"/>
    <dbReference type="GeneID" id="24562335"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101230"/>
    <dbReference type="OrthoDB" id="10320498at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28337" checksum="6284BB71A108DD37" modified="2014-09-03" version="1">MVYTSLTAIPRNVKEGIDWLVALKGDDPAKNLKAISEAVYNFLADKPVGKLDLPALEKAKLISKGFLRRQVLNDQPFVKELLGKFNGSIHKEYYKYLSFVYDIAESEYENIIESRGETAETVEDNITKVVHATEMFLDDVKNSDKYTSAYTPEATWNASCSKDPEVCAMVFVGIAPMLYTGLRFLKDTCTSAILEGERSMGEKRLGSVLEALGYNEQLRRSKMGGSDLNKALSGVDKDVLDIIYDFAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4S3</accession>
    <name>A0A061D4S3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767233.1">
        <property type="nucleotide sequence ID" value="XM_012911779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4S3"/>
    <dbReference type="GeneID" id="24563588"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202040"/>
    <dbReference type="OMA" id="KTIVRYF"/>
    <dbReference type="OrthoDB" id="365421at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="26897" checksum="7DB56067D798DF18" modified="2014-09-03" version="1">MAASDAAYQRRNRVLAESSKRLSSLSKPEYDDDEDTQPRSSFLKEVILSSPRAEVEGAAKAVEPKVTPLDLASTRCIAVCNLLSYVLSFSVGCYACHVLHPSRVDVYCPAFVRGVFSLIDMLGAARVIHMAISAWVSAPEGMQRTTVKVLTYGSVALNLYPLWASMRKGGSSSEAESNKSKDDAESSDDEGSESSDEGNGGNFLADFDEENLAKIAMFVIRSGAACLVFGLLGYDVLYNMPIILQYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4T0</accession>
    <name>A0A061D4T0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0102830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766145.1">
        <property type="nucleotide sequence ID" value="XM_012910691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4T0"/>
    <dbReference type="STRING" id="5866.A0A061D4T0"/>
    <dbReference type="GeneID" id="24562500"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102830"/>
    <dbReference type="OMA" id="FEGYNIF"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="119"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="208" mass="23313" checksum="502B58CE011C946F" modified="2014-09-03" version="1">MAASTESSISAVLARHPGKLVLYVADPSYQGHGQLQTVIESLREDFPNIAFDSIEHSAVGSDIAIDGAPCFVFFEGGKEINRLQGCSTSMLVTAVRGWNKAPGETVLERIKRLIATHPVLLFMKGEKKEPFCRFSRAVVNMLNESKIDFESYNIFEDPELREELKAYSNWPTYPQLYVNGTLIGGHDIIKELFESNALRDEIPKQYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D569</accession>
    <name>A0A061D569_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongation factor TS, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0203490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767378.1">
        <property type="nucleotide sequence ID" value="XM_012911924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D569"/>
    <dbReference type="STRING" id="5866.A0A061D569"/>
    <dbReference type="GeneID" id="24563733"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203490"/>
    <dbReference type="OMA" id="GAQECYK"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="5">
        <location>
            <begin position="165"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="5">
        <location>
            <begin position="355"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="459" mass="49317" checksum="24C50E8C110608FB" modified="2014-09-03" version="1">MELTRIAWRLLAVTWALASIANGYAYLPVRNPCANLSLSPWQSGACKQQSCFNRKRHVQRRFTGVFAEPSAEHTADAGDDRKRKILFLRTSTGKGTQECYEALTKAGGDLRAALDIIRSGMDNYVASSGALLIYPYNVLLGGGESAPVVDLLHGRVATVMTPDMAAVLELRCETDFVARNNVFMALAKSLANSALAVMRSADASAQELDAECVGNKMMEARCIRCSKTPREAAALAKMALHERLIVTRLGFIKAAPQECLTSYLHGALVATHPLNKVGSAAALLKYTLTGAPDSAAGSSAVPAAADLLTPITHDHESVPETNCVSVGAECIYAEMPAVEPSLLSDGDVGLTRSIKTFTKQVTQHIVGARPVAMTLDDYDPEKVSAARSELEAEALASGKPKDTVDRIVSGRLRKQFGEFVLMEQSRKTTMCRNGRSTAASPPWAAPCRTSRRGTARSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D582</accession>
    <name>A0A061D582_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767388.1">
        <property type="nucleotide sequence ID" value="XM_012911934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D582"/>
    <dbReference type="GeneID" id="24563743"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203590"/>
    <dbReference type="OrthoDB" id="366427at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="311" mass="34620" checksum="DFD7954DDD624531" modified="2014-09-03" version="1">MTPRVGYSSYAPSQAGEEVPKQLVQGAVASAARPGYKKVSMAMLALPQEEDLTIQDGEMGIYAVNEANNVPKTSNDVQCDALQDDGGNNDEAQKDERAPPSASEERVAVEKPQLDVSAHFDMASARILRHMKRHRKGPRSVKRKAAVPDKCASPVPDRHYGTRGIKASLKQGIKKVPSCDITAASHGEDGRPESIVKHLKRATQLLLKRKKRTCLYVAREFDEVRQTIETKFHLVLCRCQERWNNANATYIKRLDDITRGIRDDLKLPPLDRLVKQLPEPIRLQPAPNVDLCAATLSRFDSGHQTMNIITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D584</accession>
    <name>A0A061D584_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0209890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768022.1">
        <property type="nucleotide sequence ID" value="XM_012912568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D584"/>
    <dbReference type="STRING" id="5866.A0A061D584"/>
    <dbReference type="GeneID" id="24564377"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209890"/>
    <dbReference type="OMA" id="FKSIVPR"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006511974" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="222" mass="24207" checksum="AF14970CD8B43DF4" modified="2014-09-03" version="1">MPLGFNNRWTFCLPALLALATAAAAFRVVRRFEPATFLAKGYTQPLHAESSSTMSRSRVFFDIAIGGAPSGRIEFTLFDDIVPRTAENFRSLCVGDKTVQGVKCHFKDSIFHRIIPQFMCQGGDITNHNGTGGMSIYGRRFNDEDFSVRHNKAGLLSMANSGPNTNGSQFFITTVECPWLDGKHVVFGEVTSGMDVVKKMEKHGSGSGATSKEVKIVDCGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5K3</accession>
    <name>A0A061D5K3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THEOREDOXIN domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768192.1">
        <property type="nucleotide sequence ID" value="XM_012912738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5K3"/>
    <dbReference type="GeneID" id="24564547"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211500"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="730" mass="80356" checksum="843253A0113E8DE5" modified="2014-09-03" version="1">MDITADRVPVVTESSPRTVAKTTGSGVDRERGAHADTGVAGADSNNAPAAADRRFAAADISTVNGEIERLPVCDGSQEEGSTATGLTEQSSVHGSPEYDFIAEGFFTPSSEVDSGRYYRGLYTPGAGYIGASVDGDEQSTGDAPVSFRTPECRSPAAFDQLFAAGVSLRVPSPQSERSTPGVYSPQSSANVLPEAAQILLELEKKSLQQEEGLPLAPERSNSFDTVVVDHDDDSVADDHQPFGETTGNTPDRRTRRFFRRAPTKADIEADKAIVRKWFEKTANLRTITVTAGSRHVKTSQDQRWSSACKPETKEVYSYLDSSTREFDNNGCSSGHSSDCEPPNQGSVANREAVKGPSRARHNNASRTEGLQPLSRNTIIVSVLPPRQVFPKKAARATPPAPKVALPERHSLPPRLTRKPLIYPRRRRRRTMDGNAHKDVVQGDDDQQKQGQQLDQQQGQEQYQQMGGQQYQQMDGQQYQQMDGQQYQQMDGQQYQQMDGQQYQQMDGQQDEQMQPEEGQEYATEQQQDAQQYEQTQPEEGQEYAAEQFAGVTSAVPRVSAASGEFMPMAEIILITTSLGGVKYQFFQSNLARHILDCKGVVYYVVDANRDFTTATSLKDHILFEKWNAEGILKTETIGQRTAVVIPQLIIDGVSIGNTTAMQDLEDDGDLDYIIARMLCPSCLAEKPQDAVQCPSCNTQYDMLVPPEYCDGVDIQRICQGTLVGVDNAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5R2</accession>
    <name>A0A061D5R2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766465.1">
        <property type="nucleotide sequence ID" value="XM_012911011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5R2"/>
    <dbReference type="STRING" id="5866.A0A061D5R2"/>
    <dbReference type="GeneID" id="24562820"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105880"/>
    <dbReference type="OrthoDB" id="365554at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="157" mass="17633" checksum="A3D280070F288292" modified="2014-09-03" version="1">MLEYQSEDCSSRNVMLASSLFCSCGTPFVDKYRHLIHPNDDVHICTSNGCNKAFLNFQSLRGHASVAHDIEVGSEVEFYTQTGDTAVQFGDVQRILQDPASDSAQDELDEPEEEDINMSTDPATDTKPKRLPNAERSKAAKDTYRNRQQPDDLEELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D632</accession>
    <name>A0A061D632_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768204.1">
        <property type="nucleotide sequence ID" value="XM_012912750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D632"/>
    <dbReference type="GeneID" id="24564559"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211620"/>
    <dbReference type="OMA" id="KMPYNEF"/>
    <dbReference type="OrthoDB" id="361247at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="26866" checksum="33046C73782D45DB" modified="2014-09-03" version="1">MKLRRSKLQRIKRLAPYAGRSPAQAKLDKLWGFKPIDVERKDVRRKAKAKAKKVPLTPLDKVEETFAALEKVEEQQDTTVTEPENHAQDKQDAQHRKPWQLDPETARQKRAFKEAVNDLHNLVYPHLDPIAKRQYTNAKLIALGGKIAKNRKMPYNEFMQRSRALKRHVEKNKELEKELGVKLFTDTKGGSRFVDIERRKRIKELKNTKSPFHFGDRNGVYRIKPKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D642</accession>
    <name>A0A061D642_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768214.1">
        <property type="nucleotide sequence ID" value="XM_012912760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D642"/>
    <dbReference type="GeneID" id="24564569"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211700"/>
    <dbReference type="OrthoDB" id="365645at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="120" mass="13232" checksum="3D752A4B8100421C" modified="2014-09-03" version="1">MQFGALDNAYNASHEPIKGFNRHRLNGAHKFNRDEHFIYLRQYERSNASGGQGSPPFSGANRSMPAQQQLLAASKLRRNAAMIPPPSDAHVRRRIRRLSIAAACGATLMFAAATSIGVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6M9</accession>
    <name>A0A061D6M9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767863.1">
        <property type="nucleotide sequence ID" value="XM_012912409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6M9"/>
    <dbReference type="GeneID" id="24564218"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208310"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="450" mass="50303" checksum="8EB95FDAAEDE2173" modified="2014-09-03" version="1">MHIKLSYAFVHVAFGVWLANLYSALADVVKGSFLPNSVAPFADDKPYVLCLPRGYGPCDLRDRLVDQGVLRYFVIETPRNEVVSVCRGESVRLEGTLYLPERLVPHAYLCASDNKKLTFVARILFIGIIRDSVKARISYGRIFEAVAERYLPQVNLPEYMKNVFTIAVKRDSCSSDEGALATPRASSEGVMSVINYNSSAELKSVTKRVLLCGCPLHGSCESSKDFTLFIASPTIEGTITFVIGPFIDKSISVDCAYGVRCLLPIKGTYKRTTPTFAVSYDTHHNDYVLLQPHTTHYEYVIDENKYGSIEHVEVNLVWFPDGDDGSQNAVKIGTIKIHNYKHKDLLMVPFGLQEVSFKLEIAGTGDRLLIFEGPKDGDTDLVDPSDYKWRLLSEVSLENDKFIIDHNFNVDKRYVLLLSWPCVGSFCSLIEAKESVGLVSNIILQGSFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6P3</accession>
    <name>A0A061D6P3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768542.1">
        <property type="nucleotide sequence ID" value="XM_012913088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6P3"/>
    <dbReference type="GeneID" id="24564897"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302600"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="156" mass="17576" checksum="7A4AC439F61AD03E" modified="2014-09-03" version="1">MRDVEDISTLHGTYTELSNIIHDHRAVTRRKKRKSLTRERYAELQNALTKLEEQFKGIEQVASDILRFDNAAYFRAAIRQASIFIRQHTDQGSTQTHDEGTTWVGGDKSALESNTAGATRGRLNDLLQSASTADESNDTMRKLSIFNVTTICITTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Z9</accession>
    <name>A0A061D6Z9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0301920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768474.1">
        <property type="nucleotide sequence ID" value="XM_012913020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Z9"/>
    <dbReference type="STRING" id="5866.A0A061D6Z9"/>
    <dbReference type="GeneID" id="24564829"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301920"/>
    <dbReference type="OMA" id="ICESLCH"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="215" mass="23876" checksum="51CBA733058ADACC" modified="2014-09-03" version="1">MAYIPITQVDAILLLDQHGERIAVNYYPQHCAATTSADGVKNLWEDVARQKVIEKSLTKELELAKARGTEITLVSHGVTEGAYGIRMIEGHLVSYYIAADFAIIVVGPSKENEVLLTDLCTTVKKCLLSVTDEQLKKEVVCNKLDSVFLILDDVVDGGFATYKCHSYVSRIIMESDHNVIIRRLKGKSGDSSDHLPLNQAIYNIRNNVIRSLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D786</accession>
    <name>A0A061D786_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768584.1">
        <property type="nucleotide sequence ID" value="XM_012913130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D786"/>
    <dbReference type="STRING" id="5866.A0A061D786"/>
    <dbReference type="GeneID" id="24564939"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303020"/>
    <dbReference type="OMA" id="TISDAYC"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.50">
        <property type="entry name" value="Protein of unknown function (DUF3228), domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021610">
        <property type="entry name" value="DUF3228"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38666">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38666:SF2">
        <property type="entry name" value="FLAGELLAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11539">
        <property type="entry name" value="DUF3228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24107" checksum="C324C0F708BECEBF" modified="2014-09-03" version="1">MAEGTPAFTIGMGNIQTISDAYCYKQFDKRQTNHIPCSKEHFLDQLRSHFQSGMAKLADGYAPFCKHLFVRNFTEALTGFLPITADNEHLLRSGYIARTEKELPVLSRWFPRAAVADKVGPAKYLDVILYSREQVIKENEARQEGHEGDYEFDYYVISIKPQDVDHEIPMLPITMFRNTMITEGGSGVGLDRDAYLKSVAFWQNHAIIADHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D791</accession>
    <name>A0A061D791_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0209850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768018.1">
        <property type="nucleotide sequence ID" value="XM_012912564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D791"/>
    <dbReference type="STRING" id="5866.A0A061D791"/>
    <dbReference type="GeneID" id="24564373"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209850"/>
    <dbReference type="OMA" id="FNPYGYL"/>
    <dbReference type="OrthoDB" id="369783at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="419" mass="45423" checksum="041FAEBF61CAE9E4" modified="2014-09-03" version="1">MYGGRGGQYHGGGPGNSNYVGDVWYAPRNSGPREDYTMRGQGNPGGNYRSNNPSRRGGRPDSENTICRHHALNDQCRFGAKCLYRHTLKRVCFLQDVCHKGVYTLAVCRVSDTRLELFATGQGTSVKRLSLAGDINGGISLMEQTSFTLNVQYVDKNSYQPRNRRSSDQVVFSMRCINDCLFAGLRTGHISVYHIPTGTSTLIYGHSAPVTTAILVDTAVLTACEQGKICIWSFDSATNGFTCVNTIATNTTISCLLEVNDGVNRKLWAAGNSITVIDLTTLSVVRTTPIPNDFAKAMVRYGQHVIVALHSGDCVVLDANVEMVYRVPGDGVALTAMDGMQSERGDVLLLGKKSGVLNMYQIPAFNLEGTLNCNFDGPRNTKWPGISAITSLGGGLFVTAGYDGHLQIFRYSNNAGPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H3</accession>
    <name>A0A061D7H3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTPase family protein protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0305590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768842.1">
        <property type="nucleotide sequence ID" value="XM_012913388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7H3"/>
    <dbReference type="STRING" id="5866.A0A061D7H3"/>
    <dbReference type="GeneID" id="24565197"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305590"/>
    <dbReference type="OMA" id="LFILTKM"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF13">
        <property type="entry name" value="ENGB-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="10">
        <location>
            <begin position="168"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="448" mass="51046" checksum="E26ED55E3C60B77E" modified="2014-09-03" version="1">MRQFRLLASPKVTYTGPGRKVADRIKEQFSVQNDFQVRQVRKALKRYKRTEERRLLAKRRNIVLSERNVDKSKHRNPADKRAFKIVSKYEVHENPYTHFLRPLEKRTEKNPLGKATVKPVRMGIPLDTAAGLYEGASPVAQRPSGTPQVSTLQFIGSYIHTSTLPSLYLPEICLVGRSNVGKSSFINTLMTYIKTRRKSCDMAYVSKTPGYTKCINIFKAVDVKGRDVLSITDLPGYGYVKIKNRETVRAMDSALRAYLQRRNELKLILFLIDGSIEPQESDTAIHEMLKALGIPYLMVCTKMDKVAQNQVPGQILLFRQVYDVKSPLPVAYSKFGGADLGGIWRAIFDACDDKFDPANLQISDAYQSLKDADFEKYVQSQSMVSTKDLKKLIYKNFDLLPQSVQSADIDRMSKDEMLDVLRLAAERSDAIRSKPIDLLEYKKKHSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7P5</accession>
    <name>A0A061D7P5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0211560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768198.1">
        <property type="nucleotide sequence ID" value="XM_012912744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7P5"/>
    <dbReference type="STRING" id="5866.A0A061D7P5"/>
    <dbReference type="GeneID" id="24564553"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211560"/>
    <dbReference type="OMA" id="VDVMFHR"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="355"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="540"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116132" checksum="E4A90230DA7A40C1" modified="2014-09-03" version="1">MDPFDDFQVTRLPKSSKPRPPSPKRTAAYRKPKYLSSGDDVAEAGEFFGERGDHVDARHGADRAANGDSGPAKSTGRDAVYDRILDHMWYDRDDESFLMQNNYDEESQTYLADQEAKRQAQLPGGKSQLGQGKQQMRGSLSFQKHIDTSLWELSRIRQGGAGSRLSTLEMQGLNASNMHKDEVKKIVLVRSVIPPFIYDSLRKETRDALDASVAAGDNTFNHIYNKFLNQNISVIKDVTSDIAQMAKKGSAILRQLKEESERNASRVRFWDLEGSKLGALLHLDDTKPATASIRDSAGAGDPSKGGTNSNSKYAQHLGEEDLPEDEMEQKLKEYKSKLQNTREQLPVFKCREELLSYIGEFQVMVVVGETGSGKTTQLAQFLYEAGYSKRGVIGCTQPRRVAAVSVCQRVASEMGSRVGDLVGYSIRFEDLTSKNTAVKFMTDGILLRETLMDPELDRYSCIIMDEAHERSLNTDVLFGILKSVVARRRDLRVIVTSATMDADKFSKFFGNCPIYKIPGRTFPVRVEYMRSMGNDYVESAVDKCVSLHISEGPGDVLIFMTGQDDINATCELLDMKLYKVMMSSNSNDLQPFCVLPIYSQLPSELQQRVFKKYPYRKVIVSTNIAETSLTLDGIKFVIDSGFCKLKVYNPKVGMDSLQITPVSQAGANQRAGRAGRTAPGVCYRLYTERTFLNDLFDNNVPEIRRTNLCNVVLLLKSLKVKNLTEFDFIDPPHMENILSAMLQLWILGGIDEFGELTDVGRKLVHYPLEPPLGKMMIAGEREQCLSEVLTVVSVMSAPNVFVVENESDAQRETADGATREKFMVPESDHLTLLNVYKQWVANGRSDTWCAQHRLQPKSLRRASEVRQQLLDIVLKQDIKETTCGTNWDQVRRAICAGYFHNASKLKGLGEYTNLRSFAPCFLHPSSALYGMGYTPDYVVYHEVVITSKEYMRHVTAVDAEWLYELGPSFFYLKNINAGENAQRNKDKLENQRLLQEMQYKRTRQETLERAQVPGADKGSSGVTFGKRKSSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7V9</accession>
    <name>A0A061D7V9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0212240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768268.1">
        <property type="nucleotide sequence ID" value="XM_012912814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7V9"/>
    <dbReference type="GeneID" id="24564623"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212240"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7934" checksum="570FFE913D05C2F7" modified="2014-09-03" version="1">MQVVEIYAVVLLDTRQRGNTIYLQQYGQMHKWDDSTNMEHLNAAIVLTNHPRIAKYLKYPGDHTAAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7W4</accession>
    <name>A0A061D7W4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768824.1">
        <property type="nucleotide sequence ID" value="XM_012913370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7W4"/>
    <dbReference type="GeneID" id="24565179"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305410"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="10184" checksum="6F0C8ADAF8C9B105" modified="2014-09-03" version="1">MLIVYLQLVEGVRVLRVYCQLDCKKDGKSRQEAHDGTCKAIAFGYIFGGTILMLGILLLTLYICGKVHNMSLGETFGRLRDAFRDSKPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7X6</accession>
    <name>A0A061D7X6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PCI domain containing 26S proteasome non-ATPase regulatory subunit 6 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767210.1">
        <property type="nucleotide sequence ID" value="XM_012911756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7X6"/>
    <dbReference type="STRING" id="5866.A0A061D7X6"/>
    <dbReference type="GeneID" id="24563565"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201810"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="185"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="396" mass="46060" checksum="E7D942D0F0F8E133" modified="2014-09-03" version="1">MADHSHRRDNAATATMKTLPNFEIDRLRHLLTLPAEASVDTAQVKKSLLEHIVKNEMYPYLERLREQMPLMCDVPAMEDLREVNAKTLAELDEKIEFAQKNFGSSEVKDAVLEKANYYLKIGDHERAVSQYESALSQTVGVNSKLEIVLCLLRVAFFFNDVPLLMKYMERAKKDIENRGDWEIRNRLHIYESLQLIICRKFKPAAELLLNSLSTFTATELITLEELVLYTVVLSLITMDRPTIRSKLLESAEVAQVASEGSALHHLIHDFYHCNYKNFMMSLVRTSELVLRDRYMARYCNYFLRQARLPAYRQFLRPYKSVTIENMAHAFQLPAEFLERELVSYISGMRLDCKIDLVNGIIENSIMDDRNTNYIEIVKEGDLLINRIQKLSRIFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z7</accession>
    <name>A0A061D7Z7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat/BTB/POZ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0202060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767235.1">
        <property type="nucleotide sequence ID" value="XM_012911781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z7"/>
    <dbReference type="STRING" id="5866.A0A061D7Z7"/>
    <dbReference type="GeneID" id="24563590"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202060"/>
    <dbReference type="OMA" id="YKEAIYV"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="372"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="531" mass="59654" checksum="97A96DAEEEC5EC1C" modified="2014-09-03" version="1">MSSLCNNTYLLNKDISSTPGAPSPRAAHCCDVVGQVMVIFGGWVGKEPLGDAYAFHTVKRRWLRLNLCVEETYVLPPGSKKKKKFTSACLPRNNHACAVFGGEMFVHGGHDGNEWLMDMFAFDVSTINDAFDTTDPDATVDVQVRYVNGSGKVLGKRTCHSITRVDDRLYCFGGYDGSQCFNDIDCFDPVTATWTRLSRPYGKKPQPRSAHVMVTDGRMLYMNGGHSGRTHFDDTYTYNIGTHTWTRVDCSGDVHPPAIRGHAACFMNNEMYVFGGDNGDTVYSTLFVFNPRSCAWRRQTITSDNEPVCRRQRHSMAQMNGVMYVFGGYNGREWISDLHTMEYFSECTRSFDPILSSLADNIGQFLGNPKYSDVTVSVAGKKIASHKVILCANSKYFDDILSQEDPPEVIELSGWSLDAVMKMLEFIYSSRIRDFNSHTHFKLCEIMGLADSCALELLKGMCQEVLVRKIDIDNVCYMLKYSKLYNAELLRQHCFNFIGEHAADVMRTPAFDELSSVPSLVMELAKLSVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D818</accession>
    <name>A0A061D818_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0101890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766046.1">
        <property type="nucleotide sequence ID" value="XM_012910592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D818"/>
    <dbReference type="GeneID" id="24562401"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101890"/>
    <dbReference type="OMA" id="GDDMHYD"/>
    <dbReference type="OrthoDB" id="361447at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="933" mass="103138" checksum="CF3E99DF773C54C3" modified="2014-09-03" version="1">MVNDSAAVEPPTETPVEAVTALAASVMDYTPTTQSEKVTQDSSEDAGNGLGMTVEDEELTEQDLSEEDEDSLREPSVKRYLPGVSVDLKLKAVYAENHGAKQQVPMMLDFYAECMKTYRDEKLFSLEEHYLGAKSSQVTDVTGRDRKKAPTANAAQANADSKPDKAGSQDDTHSGAEVTTEVSLDDVMWMKTRPNDPLLRCIQSITDRLNIQGIVGDPTSYLKVGGDDMHYDIDDPFIDDDAMFSELRLSKNDILRKKQKERDFSVWSEDEEEAFGSELVAEDFVAQYSSELKIEDDVDSDIPKQQVLFFDPPGWRRYLGRIPKQFHHIFHEFEVKYKGYSGQFTTQTLRCAVTELLNAIFTRLTKIQEPRQRKAQPEGDATNASNKNPIEEQRMEFERRGLKCVGVGKIIGVNGRILRWIAAAIWEVTNAVSRRDMHETWLKLVLDHNERMISEMRDRMHSKWLSKVEPLKARKDVKFFTRLADNMKHVSKSVHTVRRVMRDYEAAFTAASDNFKAVERKSVKNGTSTKKVNSRSDQPPATEAVGTPKNATSRPDDIANLNSLSPTNLLTQETDTVEPKDETPTPRQSNESVNADHGMTDVSPRSTLSDATGKSVSVTRTPSRAIDGGHSPVDGALMSADLVVNTSQASTPPKGLSFEIAQNGKGGELNDGVDVDCCSFANILRRCSLWKRVSSLITLYKYIAADILTWVQMINLALATSISIAATDFSSLVQEEVHGEYVFDKAYGCIADLLTQVVEEVSGTKLIITADVSRVVVMYIHESSTFDDLFEQENKDPIVFYDNSDIAAAPGKVQLVEAKKGSKSGKAPAGKKGNSAKASDKNVKRIRADEGPPDSTPRETAKDSNPQNAAKLAKPRKTVIEFANTVESDAPQTPKNVKSIKKAKCQSSENTPMAHTPSKAGDAGVAVKTEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D846</accession>
    <name>A0A061D846_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766081.1">
        <property type="nucleotide sequence ID" value="XM_012910627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D846"/>
    <dbReference type="GeneID" id="24562436"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102240"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="88" mass="10018" checksum="3DB44C229642AEB0" modified="2014-09-03" version="1">MLLEGERKRLAETDTRRSLELAAYFSCCNLLIESLLCSLIIYHSSLGFVFHVGWIGALKLGTWFETVHLRYSAVSVISPPHVSYTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D855</accession>
    <name>A0A061D855_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0202610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767290.1">
        <property type="nucleotide sequence ID" value="XM_012911836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D855"/>
    <dbReference type="STRING" id="5866.A0A061D855"/>
    <dbReference type="GeneID" id="24563645"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202610"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000116">
        <property type="entry name" value="Arginine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="471"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="597" mass="66865" checksum="5706DDCEA28408D7" modified="2014-09-03" version="1">MKIIAQHVKDVIRGALSSCIGQTLLQEHLPSLSVVTANPKFGDFQWNDAIALYKAIGKELSVGSSKELAELVKTHINSPSFSSINVSPQGFLTVTLSKGFVEDEIRSLCKNGVTVEQAPKGCRVAVDFSSPNIAKEMHVGHLRSTIIGESLARILEFHGYEVLRINHLGDWGTHFGMLVEYLMAKHPDFMTNVPSISDFTQFYKEAKALTDADAEFKAKSRKRVVMLQSGDEVSIKVWKLLCEISEREFGKIYNMLDITIENRGESFYNDMIPDVVKELQEKGLVVESEGAQCVFTKVNDVPLMAIKSDGSYGYDSTDLACIRYRIQEQKSSWLIYVTDIGQNEHFMKVFEAARMAGWTKLNGEEVRLDHLGFGLVQDASGNKFKTRSGDTVKLITLLDEAVERATAELQSRINARMEEGETDIDINIPEVAKILGYGAVKYFELKQTITNNYKFSFDHMLDPRGNTAIYLLYAYARICQIFHKAGIDANSLHPEVLDLSHPAEMALAKSILRLPAVLNQIKVDYLISKLADYLYTLSVEFSSFYKQCKVIGDPNEATRLLLCHATKTVMQVSGYDTVNINAQTSFQLMGIKPLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D856</accession>
    <name>A0A061D856_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768904.1">
        <property type="nucleotide sequence ID" value="XM_012913450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D856"/>
    <dbReference type="GeneID" id="24565259"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306220"/>
    <dbReference type="OMA" id="MISTMFY"/>
    <dbReference type="OrthoDB" id="361079at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="137" mass="15835" checksum="D9DE29BDDE4C039C" modified="2014-09-03" version="1">MEILLETVKVLTSSLSKYATSMVVSAASRNHISSVRRKLSGKFFNFSPFRENADTKVEVVVKPIDDEEAIKLGADLIADVLLMSLMFTYMFYSLYLRRKKFNDLCDRQKEREQFILARLEYLEAELRKLQQTGAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D877</accession>
    <name>A0A061D877_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766116.1">
        <property type="nucleotide sequence ID" value="XM_012910662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D877"/>
    <dbReference type="GeneID" id="24562471"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102580"/>
    <dbReference type="OMA" id="CEVIINR"/>
    <dbReference type="OrthoDB" id="365122at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="24613" checksum="9CE05210DC332391" modified="2014-09-03" version="1">MLEAWQKVQQNVDTNLRAMVILLDKFLLFVGADEVDATEQDRMVDRIIESYTNRGSEKIAVPVAYHEAMDRLAAITAASRNDVGAASPLVANVKANLPDAIPMFLQRQSDKMLQMMAEISAECSTFQAATLPKMELVFDAAVVHINRSSTHQQQPAESAVVADGVYRSFMEIAREIQGLLDLVASMNAYPVGQQQIQSYIEQINAFKLVPISHYRKIILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I6</accession>
    <name>A0A061D8I6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766246.1">
        <property type="nucleotide sequence ID" value="XM_012910792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I6"/>
    <dbReference type="GeneID" id="24562601"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103740"/>
    <dbReference type="OrthoDB" id="365694at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="125" mass="13482" checksum="95B0312D84311F70" modified="2014-09-03" version="1">MPARAAELGSLRESGAASGAAPSKARDRVAAFQELAKAKRGLPRHLVAEIERRKVTSVEEAAHVAHVLRTKRTKSHKIATPRKPLRKSKAPKSPKPAELTRPSGKAARKVISRMTKALNTGVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8V9</accession>
    <name>A0A061D8V9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769332.1">
        <property type="nucleotide sequence ID" value="XM_012913878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8V9"/>
    <dbReference type="GeneID" id="24565687"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310490"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="134" mass="14355" checksum="C03FF817F5A67E41" modified="2014-09-03" version="1">MHKPQAINQYENDGDDEGDGGDGLGGRVIGGIWINNFCANKLLRSAVERDAERYLAYEEIADVAAHREAEDAQVEQDDGDDDGNDDGGDGGGGSSYFTAHIPHPVERPDAEVAHDADDYDDEDDGGDDDGNCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8X1</accession>
    <name>A0A061D8X1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769342.1">
        <property type="nucleotide sequence ID" value="XM_012913888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8X1"/>
    <dbReference type="GeneID" id="24565697"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310590"/>
    <dbReference type="OMA" id="YFIVSMG"/>
    <dbReference type="OrthoDB" id="361847at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596107" evidence="2">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="197" mass="21192" checksum="9765C4EFE78ED8CB" modified="2014-09-03" version="1">MKSFLFSLFAFSGALLALLLVGAEKVNDAPLVSHKPPTGNSLLTNTSECATLHGNGLRVCSTVFAVDGELDGKRCDEAACKLQCCHAAKQCQQSHYLSLTSEECIYSQLQQRMGRCCVVGKSTGATMVYAGGAVVGMIIVSGLYFIVSMGSHKKVIKGEKPTDDEEGEDGKLYETKTPHMDVNQLIATDGDDVFWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9D2</accession>
    <name>A0A061D9D2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768788.1">
        <property type="nucleotide sequence ID" value="XM_012913334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9D2"/>
    <dbReference type="STRING" id="5866.A0A061D9D2"/>
    <dbReference type="GeneID" id="24565143"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305050"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="210" mass="23238" checksum="3592253649EBA163" modified="2014-09-03" version="1">MLTWLAGLRNPKHHKTLEKCIKKAFSGLHNESSDLALSVNGSHVLPQHVFDILQLTAMFAGSVLTAIAPNWRASVASRTVKPNSSTQSDELDCSALLCQLLDYVYACHHQLQFLKAQCKRDKLSGGWKNDEYGSDITSSKSPLQAFLTDGWDSTFKTHPFDPCNLCLRSRVRMGFRDRDLPSSQQTGDTLSSILTPSCGGEQHDSLVDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9E0</accession>
    <name>A0A061D9E0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768798.1">
        <property type="nucleotide sequence ID" value="XM_012913344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9E0"/>
    <dbReference type="GeneID" id="24565153"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305150"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="6407" checksum="DDA45449B3E7441B" modified="2014-09-03" version="1">MGDWKEKLGPGIGAAVAGFIAFPALAVLVLYIMGRIYNVSLGEIFGQIRDGFRGSKPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9F0</accession>
    <name>A0A061D9F0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0106390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766516.1">
        <property type="nucleotide sequence ID" value="XM_012911062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9F0"/>
    <dbReference type="STRING" id="5866.A0A061D9F0"/>
    <dbReference type="GeneID" id="24562871"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106390"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="850" mass="93494" checksum="F86FCB7936EA9464" modified="2014-09-03" version="1">MPSSVVGEIPWRRGDVEVLHQFLLSARDRARATCSGDRGAEPSPAHTYNVEKDYNADSVRPCDRSTGATSGVVDSRQSSAGSGYRRDVSHNPLRHFYSAPKRSRKRASPSSDDAGERLSSCAANICILKGQTGSGKVSAVRRLCSEIGLKVIEYDPFENDVVYMSDGQAQDAFSATFLRFLDTVRRKPGLRISRDAGSLKAPAVQSDASSRRLKCIRMLFGGRRSQGDADTLPSKSQEAHLILLKDLPRTVLSPSNTPFNRRVQEITRSILDGDGFHEGLSMYPLLICVDNSNSDRRLLRSILPYNYENHPRCMRLNVAQITRAKTKALLFRFLSALGRPCSAFNEQLVDYLSRACCGDLRFGMRNLHFFSSVDRSSLQSAQSEMEALLQHMCERSPTSAVFNVLGKVLVNKRVRAILQRDASPLDEEDVSALQSSGSLGVERFRECFELSRGVYCGNFGEGGDNSGITEDYSDVLEILSTISDDLILMPSRVLAVEPPSQASDIDEALSRSVVCGYGIVRPGCFDASLLGALPTSARLFGLIELYNPSLPLSMCRWPVIIGAASEEPSRQPRSAQLPLLTRPQLYYNPDELVDSGNVDASFLVDSVFENYSHYFEDIDDCAVLTTHLCDADVTFTGYRHSGGMPDDGWEQAQSTFACLCARAACCCNLGGSGRPANFRMFTKGVWQSESINDMNHLKALYDGHLRDLIARADGGHPQWHLSSAYICKSRAFVEIVPFMYILLSNSCDPSPPNVPEQDAPLLDWSLGSSNVTESMLERIDMLMSEPPHATPRNKGNSSADFKAALSSCGILESVTPKFKELVSEIGKHYECISGRQCPSSSGCLDIDQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9F2</accession>
    <name>A0A061D9F2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766521.1">
        <property type="nucleotide sequence ID" value="XM_012911067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9F2"/>
    <dbReference type="GeneID" id="24562876"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106440"/>
    <dbReference type="OMA" id="RQGENQG"/>
    <dbReference type="OrthoDB" id="366421at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595591" evidence="2">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="469" mass="54524" checksum="41170BC7E61DE0B4" modified="2014-09-03" version="1">MRSASIIALFLGLLAGFSPVIASEPNPSLVHDIRADRTRVIFNLQDVVDNALFEVEQFKFDTLPVLSVSPRSDYKLTAVKNGNDTIFECEDVDEDEIYLVLVRVGEAETFVFVNSTFGISFFEKVGDQFREIEKVEELPEYVKPLLPFQTHQEIFAPLCGSRPLTQSVNEYLKNREETEDDVDIFDDSDSEDEYDVYEEEDYVEGFEELNDELYDEQYDEEAEEQYYEESDEPHVDETDEDFYDETEEQHYEMLEEPSYEEVEESEYEMPEEPSYEEVEESEYEMPEEPSYEEAYDESVEQAEEQAEEAVEEAVEEQAEEAVEEQAEEAVEEQAEEAVEEQAEEAVEEQAEEAVEEQAEEAVEEAVEEQAEEAVEEQAEEAVEEQAEETVEEQAEETVEEQADVSKYDEAIDELFQQIEDQADEPVEQKLEEVEEKIEEQVEEKIEEQVEEKHEVVEEEHEQQLRGSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9T4</accession>
    <name>A0A061D9T4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 90, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0306360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768918.1">
        <property type="nucleotide sequence ID" value="XM_012913464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9T4"/>
    <dbReference type="STRING" id="5866.A0A061D9T4"/>
    <dbReference type="GeneID" id="24565273"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306360"/>
    <dbReference type="OMA" id="EINPNHY"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000007">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596126" evidence="7">
        <location>
            <begin position="32"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="142"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="238"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="798" mass="90214" checksum="F9E279BA73B01A14" modified="2014-09-03" version="1">MTRAAARAGCRWARCAFVGLLALSLLLVTSAFRPKPKFVSSLQHRRQEPHLQVEGSRRAPPLYGSSADEPSGVTSGLQDALQHKIGLSSELSGMEDAKVTRLDDELGLGALGPDVKVQDEQSFPFQAEVSRVMDIIVNSLYTDKDIFLRELVSNAADALDKRRIQADPEEKVPKEAFGGIRIFPDKEHNTLTIEDDGIGMTKDELVKNLGTIAESGTAKFLKQLETSKSTDTNNLIGQFGVGFYSAFLVANRVEVFSRAYGHEDGPIYRWRSDTSGSFSVGQVDDEQVSSSFMKTGTRIVLHIKPECDDYLEDYKIKELLRKYSEFVRFPIQVWVEKVEYERVPDESTAVEGKPGRYKTISKKRHEWEHVNTQIPIWRRDQADIKPEDYVSFYKSTFKAYDDPMSYIHFRVEGQVEFSCLLFVPGSLPWELSRNMFDDESRGIRLYVKRVFINDKFSEAVPRWLTFVRGVVDSDELALNVGREYLQRSKALTVINKRIATKALDMLKNLKAANPERFRKFSDHFGKYIKIGVVEDRENQQELASLVTFWSTKSGQNRVSLDEYVGRMKPEQSAIYYLTADDIKSAQSSPSLEKLKALDYEVLYALEPIDEFCLSSLTAAKYKNITVLDVNKSDLKLKEAADGEPSQKQNPVEFETLCGWMKALFPDDLHDVKVSTRLVESPAILVQTDFGLSPSMQRYMKQQATSAGMNDTELFGTSMISKPVLEINIDHPIIQHLNAMVKTDKLSDLPRQVAKQLLDVVSIQGGYSVKDPTVFARNVLDMMQREAKQFLDAKSASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X9</accession>
    <name>A0A061D9X9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766736.1">
        <property type="nucleotide sequence ID" value="XM_012911282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X9"/>
    <dbReference type="GeneID" id="24563091"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108480"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="132" mass="14616" checksum="EE22F7F165E9ECD4" modified="2014-09-03" version="1">MAAAAEQKCNCVGNQCTDEQCNCCPWCCDSCKGSQCKSKKKCDTKTHKCGLEPKHKPCTEPLCGCRCCISKRESASANVFWCIIGALIFAIFLAFAYIIYKTKSKAYMIPKVVYEWTGYTSTYSGLGSKNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Y7</accession>
    <name>A0A061D9Y7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0108580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766746.1">
        <property type="nucleotide sequence ID" value="XM_012911292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Y7"/>
    <dbReference type="STRING" id="5866.A0A061D9Y7"/>
    <dbReference type="GeneID" id="24563101"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108580"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="616" mass="66841" checksum="CD797FE8891D8259" modified="2014-09-03" version="1">MTKTFFLFETAAGYALYQIEQWDQIGHVEAMEEVCSSEERFKETVKFKAFQPFTTASDALENIRAVVEGEVTAMLSSFLSLNLPKKGTQLAVVDPGLGKTLSAKGFNVVYDPNVVELLRGCRQHEMKNIARLASGASAFDMDKFHVGLSHNYSRSKLQIDPRRMDKPVINCVALLDSLTKNLNSFAMRVREWYGWHFPELIKIVPDNKIYCQVVQIICRKDKFDWEAGAAELLKVLGDEDIVANVKKAAGQSIGHELSEPCMENILNFAKQVVKLEEMREHLNTHLANKLAVTAPNLSEVAGNILTGRLISHAGSLVNLAKMSASSIQILGAEKALFRALKTRSNTPKYGLIFQANFIGRASLKHKGRAARYLANKCALAARLDCFCDVNTNVYGKRMVELLGKRMEYLAGGPQHETSIEVMQAAAKEYQAIKAQKASEKRTRDALENAPQHESAHDVSMVSGSADAEPADDASSGTVTEKPAKKSKKAKKDKSKKSDIAEEAATEDTADVAVASVAPQKEPKKKSKKSKAEGGASGKDSSSSATDASSTSVTATTAVAASKVEEANVAAAVTSAEEGPKKRKKSKQDKSADVAEAAEVGKPAKKAKKNKKKAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA35</accession>
    <name>A0A061DA35_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766796.1">
        <property type="nucleotide sequence ID" value="XM_012911342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA35"/>
    <dbReference type="GeneID" id="24563151"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109080"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="79" mass="8147" checksum="05D662B29373F69B" modified="2014-09-03" version="1">MDAKTTRSAMGIGQAMDLVTGVLAACKVGLEVPGLRAEQSIKVILDATTVELGKLGRSNMPLTDDKAPLSGGDGSSWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA44</accession>
    <name>A0A061DA44_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0307160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768998.1">
        <property type="nucleotide sequence ID" value="XM_012913544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA44"/>
    <dbReference type="STRING" id="5866.A0A061DA44"/>
    <dbReference type="GeneID" id="24565353"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307160"/>
    <dbReference type="OMA" id="MKATHIL"/>
    <dbReference type="OrthoDB" id="364268at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1142" mass="129239" checksum="F338834178A6AAEF" modified="2014-09-03" version="1">MKWKVPRALRAKVHAGVAPNGNRRPAHTLKHMPFADDFMCARLPTANLGVELVKGAFLGFRRHAVNRFLKALALHGNEVHERSRLVQRDDKYAHDMDAILQIYLERMPLDQLLVLYQVCRHSILDIYKQINLKCATVNSEIKYSFIEAVSQKLVQYMRDVTSHETIGHYLKNATHSARTRCKRYEKELCEFLIQTRHNLLKTRKEVFEGAREGNPSAESFVTFERKRINPCHQLGAATSVENTPSCIKTKSISLPGGATTLENDECSDGLFTAPPGDESSVGDVGMPVNTNRCATESSQCLLEADWESVCADDSFALTHRTMTEDCFLSTDVMGTVLGHMFAVKFWHRGFPFHTWINQYFVHNSHIYHPLFARLYMTHIVALIERNTNPVNLDALCDVVKQDIIMYGNRDVSMEEMFTVRTNGYLHEVKFGIPEMIEMFSSVKRLSQNAKLREVYVLVVKALSDVIVKAPVDAKVINTIANICNRNDGVGGVESLLYVLESKLMSSLDAVTCMDVCSLLQALHKHDLHSQDVVDAMADKLDIDNLDELSMSTIALSIQTLGRMQAHFKNNNFLHRIANMLADNPQKFYEASESNCSGILWGLYKLHFKHPRFLEMAVQRYSAKELGTPNVNSLVISLTALTRLDSFTHPSVLVEIYKLILRNISSMTISTSQQLVTCVTRMLENITLCCSDQTSYKTMRSISNKLINAAMKHVCERLVEQINTAQAGAMLNALYRSKLRAPDLIAPLIASIAGAYKKGQDWQSSLHMPRKSIYSYDTMPDCPFDIEACGRKLEKVEITHLVGICEAIYGLDYWTPYSLNLMMQLQKHIKPQLHDMKATHILAACLSFSSWPFTDTQMEPINPNNAPAKRSRTTNMMPNVRAVVEHDLAKTKERSESWLEANMLQPPSADVLSHFRKMLMRSQLKEDFLLRCIESLHRHANFLCAASMPLRRLKIMYDMLRYNIYLDHYDTAAVVLPTVTNEFASTKCPFLILEHNAPVKPSNLPIVMPQNLIEYLEHLYGISRTQSFHNFIFEEGSAQNGGTNGVEEEDEIQMEALGGVETISNGKEVPRCRPLYSSPTIGDGGWDLESSSYHNHQGSGAIFHFGDNYMYVDPVIGGFRTTILLLNAKRHNVPHLVHDIYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA57</accession>
    <name>A0A061DA57_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769018.1">
        <property type="nucleotide sequence ID" value="XM_012913564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA57"/>
    <dbReference type="GeneID" id="24565373"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307360"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="461" mass="50210" checksum="53D588D198AE77B7" modified="2014-09-03" version="1">MVYNSLTDVPRDFREGIDWLIALKGTDAESNIAAMGEAVYNFLVDKPVGHTEVPALQNVQSIVKGFLEQPGLKNVWPVNRILEKYNKRINKNPGWFTKAFGGADECDYKNVIKSKHVSAKTIAGKLGIAVNGYERLLKKVKTPEQYKSAYSSEATWEASCSQKPEDCAVVLVGIAPMLYAGLRSMWKASHGQSFSWVPKSKNKNILVTVLRSLGFKHPECRDKMSASYVSEALENVTIDMLETFYNLSGFWAFYGSGKIGAVGEKQPVEPVIPEAEPSVEGEGEQSLIPEAEPSVDGEGEQSMIPEAEPSFDGEGEQSVIPEAEPSFDGEGEQSLIPEAEPSVEGEGEQSVIPEAEPTFEGEGEQSVIPEAEPTFEGEGEQSVIPEAEPSVEPAGEEPVVPEAEPSVEPVKPEVDEVEQPMKVAKAAKVARSVKAAKKAAKKVSKKARQKKQKKQQESAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB2</accession>
    <name>A0A061DAB2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769674.1">
        <property type="nucleotide sequence ID" value="XM_012914220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566029"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313900"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1747"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1809" mass="201886" checksum="6927C308BF4C0625" modified="2014-09-03" version="1">MGFLSGVLSNIHKHLGQHKGEINNAITSLETNKHAGKKGFSVAIVKVVEGVGGYNDGVMKSNKRVSDPIIRLLEQVNDAFKKQVSELNKNIDIRRPQTAQEAALDAENLVKQSVRNATNFFETLDIDRNHKDIKISINDLNSNLRDRVNIACDSVKLETKHLRELSRKEEKHLQDMEREIERVLTDAGACVNREIRGQVTKLINDMKERVTKIKLQLEDIKRTLTGYVDELTKWIDSVTIVITAALGRVDSILKEVNKGDSSMKPYKIEGALREITASVLILHGAGEAAKAQVKEKVTAALGQVKDMNDALKEDLYKVKGAIKGAIWKHVEESIRTPYEKLEGHVKDGLWRIEDAITRILTPLKTNSDGFYEKIEATQRAIQEAISGVESQLSKLQILDVAAINGETKLLQAIKAGDAFDSVSEYIMTLDTNVMVQVQAAINKMGAVWKKFASGAIYDDVQSAVKEAAQELRALDGIANGTVQITDLQSVTMGKENFQGVDSIREIIKPHVSAIQQILPKLIGRSSSISREEVESILTDLGNIAKSVSQHFKDVLLQVIEVIEIQLASEIGTVAQAINAKVDVIIKGVDNGDESDVPVTYSDGSQHKNSRGLQALVDDFNKNIKQKLDNLKSTVIPQTFKKKDTQNYGDGTKNYDFDHIMKTFKTTYDSINAELEEGKFQKAVADKLNTEIGGDAMGRPADVDRISDLQRGKFVNYEKQVQQDSLIGDEPEKFEGALPKKIRDIKTQVEQALGKIDSEKQYAEEELKKVTTALHELFQLIEEDAQFARGNLTDLRDKYFGAYDEAKRIGTESIQKIKQQLVLLHEIDVTEVIGLADDFIQKDARNLQDKYIKSLNQHVDNQVEDAKKLITQKARVDHVTSTQLLLTHFADRVTAHLKGLPEAIEKDKHTGFKGFMEAFEGKPAPPPQWDLYAPRNQSSKLEEFKGAVTKKQASKKEEFKTLSQEFKKLYDPLNTYLVVELKRHHTETMSNRNPSVRVVDGDPIPHTKNVGDLKDKLDALLQHLHDIPAARKHLFDHNFSTKLNTLQSLLDNLRPASYADDSNLLLECLRKGVQGMHDELAKAYISAYDSETFGGEMFEKQKLTPYGAKFAKICFTVVCTLNSTLTDLTHNCKSLRGQQINKSTDVGRSFVGHGYAVSDATLQNGELQNRPTVAGENVAKRLLLPIRGADDNAHLKGCKSNEQRKDNHFHVFDAIDCIFSHFEQYNELCHLLTASARQHPCSVYDILIWLSGFPYTAVYSTMRDITISDLFDNPHKKAAGDDELELTSTDMAAQSITAHPRNISYNYVRKAVDHICATSYDVLTAVVGTGDSRTVYASDFCNNSFNFHYPSDPSDCLDMLLDLLRRLLPVFRFLELQCNITPEHHGWSHCRYGRDIPTTKSQCNEHSGDEANSQARCQVNCQPTSPLMLYLSDSLPGHLPHQLQSVGCRAKCSTCSKSSPGQPCLLPLGFKGFSGSTKTGRQLCDAIKTFLGTGLISSLMCLLPKPPSTLPEHFQFVLTLVGAFNANRDVNSNAVHAAFVKAIKKQSIDLCADPGTLTGALSDAYKNGRSHEVGEHPKASDSDLSTLSMPTTCNYPNKDVHCAPYLTTLHNDAYHYAAEKHAGLYLSWAVYLPWSFWQCLESLFRAFTNISCQDWGCRRCTHGTACKRGKHGAAYNCQCKGLVECRGVISTLYSFGFTFGNPATLSAAEGKRYCHNFYKQLNNVLNSNYFRTLFEKCDEFIFTIRGPFLWMTVALWSLSLFYLICVMVGRLDVLHIRSHLRIPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB4</accession>
    <name>A0A061DAB4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768000.1">
        <property type="nucleotide sequence ID" value="XM_012912546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAB4"/>
    <dbReference type="GeneID" id="24564355"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209670"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="121" mass="13716" checksum="53629891683AC94C" modified="2014-09-03" version="1">MQQSVGATLNLSERRQQATRNMTDAIQTVEVNSSSPSAASKENLISGILLALVAFWFQLKKGWDEVWKVLSLEHCPLCVKPHCGKYCVYVISICLILFIGLLYYVLCNPLRFFKGIFCCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD3</accession>
    <name>A0A061DAD3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768025.1">
        <property type="nucleotide sequence ID" value="XM_012912571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD3"/>
    <dbReference type="GeneID" id="24564380"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209920"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="78" mass="8768" checksum="7F0B1464F053BBE8" modified="2014-09-03" version="1">MGLSDDTHTSGTLFVTAQEWVMNRRYIKAISTTILVASISSYLKAFMNAAISMNIRPFYNAKDFIGVPAMYDHEPALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAF7</accession>
    <name>A0A061DAF7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0210220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768055.1">
        <property type="nucleotide sequence ID" value="XM_012912601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAF7"/>
    <dbReference type="GeneID" id="24564410"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210220"/>
    <dbReference type="OMA" id="CRIGVKR"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="27831" checksum="338B7182E2EAB205" modified="2014-09-03" version="1">MAWNTLYFELPIFQTHFGSNVTCPFKKLFVSMTLYGEVSNRNDVVRHAMEVSEVAAPAVPDKRMATVGQDGLPASSEPDCRGMLDFELIHLILHPDMVRGSIKRAMCSQVVSVEHVSYAISRAVTNVLNRKVHSAHFTTEVVYMMGGSSSVTKCMDEMCIQTSITDNTCKAMLAVSISKTKVSPTAAANYMNVQIFGELESLVRGVQMPIEELKQMRNSEKIAKAFKCSKEEIMLPGGLEACILGRIGTKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG3</accession>
    <name>A0A061DAG3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0308700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769153.1">
        <property type="nucleotide sequence ID" value="XM_012913699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG3"/>
    <dbReference type="STRING" id="5866.A0A061DAG3"/>
    <dbReference type="GeneID" id="24565508"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308700"/>
    <dbReference type="OMA" id="CSHGTYI"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596144" description="tRNA pseudouridine(55) synthase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="285" mass="30997" checksum="96A8D59825D28EA6" modified="2014-09-03" version="1">MTVAVLLQCVVVVASAVASGFGLRPLRPQPPPISGILNLYKSPGMTSNDACQIVKRILTDGLRERMATPRRPKIKVGHGGTLDMHAEGVLAIGVGSATKLLSFYLKGSKTYEATGVLGYETNTLDSHGETVKEAPWQHVTDADLDSAIQSMQGPYDQVPPLYSCRLGSWAINHETAKKHCGRSLRDYAIRSLPVEVKSSLVTVHSIERIRVPGAELPRFALRVTGSGGTYVRSLIRDIAYKLNTLGTLQSLVRTAKCDLTVDDALRIDSLDYDTIVQNLRTQNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAH6</accession>
    <name>A0A061DAH6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0110230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766911.1">
        <property type="nucleotide sequence ID" value="XM_012911457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAH6"/>
    <dbReference type="GeneID" id="24563266"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110230"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595956" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="815"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="945" mass="106863" checksum="634F2FB1D82515AC" modified="2014-09-03" version="1">MAKLRIMKFLWVFCAICLYCITGIDASVCDFGRPDQLPVRNTLAVCHKNADFMKLETVICPRQVDGTEYVWHPQSTSADHVRINTYVGVNGKLRSVAHSQVVRSESGKRFFWVEPEQLQMKLHFYMSFHEFFAINERRLIFICGPRNLVLTDALQQYILQQSALQPETRPRSSTIPLTKEIAKTGQSLGVVFLYRKNMYQPLQGCGSRPSPLFAPDNEVDVDPETGTRSCVADPMSESPIGFLCEGRVEPYDCMISLVDKTGKVVKPPRPQSHRTFGRQSPWVVSKYFSGLALPPINGRCYCIDTKTGQVNAKIKIRSKTDYVCDIASMIEGNKSNPKRGPWCSVMLNPGSTLTIRVPIMGVNSESDEGSSQLLPTEFLPKDLTTMRQQTDLYDSDSYEEIPYHEALVGDALELDLSQMHRGEVKLRYHVGKLLTLKSGLNSFYYQCTLASNEDVSDSIRAIVNVSFAYTHHYQMRGCDRGAQAIFDPITNKSYCSTISMGNDIWNTYQCVYNIWQVRRAGIHCGIDEELLPGNCEATIYDVYSDEIIPMPSYVRTTTPLSIPGFQLFKIDIGNDGAFSLACFCVDQRGYETSRVVFKKMESVYYTFRTRRVDRTLTRTRISYMLLKTADLLLEESTPTNFIMVHKALTRSITLAAGKRLILECKFGFHDIEVYNGAMQIEEGWPLTKWWPNQPDVFYYAVTHTKHGDQLVRKTYEDAIVTIPGDFRPIYRDLLTTHRYQSLIIETQKDSLIISKDPMHKYIVPLAFVCGKELEPADVAIIDGEVPASPTTHVLRSSKVFTWHLVEVNLEATDPYMQGCGVTYESAGLFKPETPQLYDAAGEPQFGCKIDLQAAKEAAFYCPVPYVLDPPGCFNNVFVDGIVKNIRNISQSLVVSHSNHFVSLQFDSSRIGRGETLRKTPPLQCQCVTIKGVVLSTIQIKHYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI0</accession>
    <name>A0A061DAI0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0400500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769744.1">
        <property type="nucleotide sequence ID" value="XM_012914290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI0"/>
    <dbReference type="GeneID" id="24566099"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400500"/>
    <dbReference type="OMA" id="NTLNTHS"/>
    <dbReference type="OrthoDB" id="366194at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="150"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="396"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55290" checksum="EF8CD4139B077B10" modified="2014-09-03" version="1">MEGRFNETGGAASADKTKMASQRSTGGHERSSYWYPRAYKPMDSRFDAGNTLYLGGYQGHSANNGWSDDAHLQFDHSDRYGTGSYSRFMGEATAYAHNAYSNAAKQAAVQASSPVAAASSYNVVTPSEGSGSNAAGSTGSNSPQMNIDEIAHHFVYRYYSLMHSNPAGMFNLYAKNAQLCKPDIRGNRVVANGHTEIKNFYALLAPNQTTSNIKKIEMQSIGSLGTIAILVVGDVTMRIGNKVETRCVSQVVVICGDQTRSRFQIVNDMALEDINVAEKLEKIVLPAKAQDANEAKETKDVKEAKETKDTKEAKETKEAKVTKETKEAKVTKETKETKETKEVKDTKDAKDSKDGKETKVRETATRSKVRSKPQTREASKTTEGRRRSVSEGRDKTKIVLFGLPLNTNANDVKDAISKCLKDAKLVEVSNVRVDLKRAHRGGERSPMFAFVQLDTREAAEIIIKEGVTLGGKALSIEPYKRNRGARERSSVNKAAREENKTGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI4</accession>
    <name>A0A061DAI4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769892.1">
        <property type="nucleotide sequence ID" value="XM_012914438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI4"/>
    <dbReference type="GeneID" id="24566247"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401980"/>
    <dbReference type="OMA" id="NDYQVEH"/>
    <dbReference type="OrthoDB" id="365461at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600200" evidence="2">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="186" mass="20767" checksum="E0076CAB4D11E491" modified="2014-09-03" version="1">MTFHVYYLVFSILAALLCTPAACDIDSFIDHKNAAIPLRELSGVSRRKYLQNDMARLVAAPSNVSRMDSDEEDDEDDDDDEGDYHHVEADGTGSATSTRIADITTSKQVDSKDSVKQERKPLLMGSLPTHTEKSDAPVCALDVISDFLNRLSEKFHSSMNEFFENIDKQIKANSELPLLEQGDTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM0</accession>
    <name>A0A061DAM0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HVA22-LIKE domain containing PROTEIN,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768135.1">
        <property type="nucleotide sequence ID" value="XM_012912681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAM0"/>
    <dbReference type="STRING" id="5866.A0A061DAM0"/>
    <dbReference type="GeneID" id="24564490"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210970"/>
    <dbReference type="OMA" id="MNYIPFY"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="159" mass="18727" checksum="F95280F4A5479CC0" modified="2014-09-03" version="1">MAISLLSTPTYWVLNLALCVLYPGYKTFTHLYHGLLSGHDDASAEDPRTNCGLFAHHILYWTIFFLFLKLETYFLVYLIPYFPMFYELKLLAFYWLSSYEFKGAGYLFHRFVMRHMLHTSRLIQQELDTKLTPSHRKMISDIGRHLGSVEDVQFANAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP8</accession>
    <name>A0A061DAP8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD 40 repeat domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0211310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768170.1">
        <property type="nucleotide sequence ID" value="XM_012912716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP8"/>
    <dbReference type="STRING" id="5866.A0A061DAP8"/>
    <dbReference type="GeneID" id="24564525"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211310"/>
    <dbReference type="OMA" id="VVANWPN"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="435" mass="47325" checksum="401A9099F47077AA" modified="2014-09-03" version="1">MAEDSENKADFEPRDADKTAAPSMPVWKDDDDDVEDDLGGSAVTSEPDWVAKRRRELLETDGKGELDASSALTGKLAKVKPSSRTSGVRFRIDRQGDSRFNISVDGGIAQVGFDQGCSVLAVLGRRSKSVLLYEVDRHRSEGKYFRLKGEMSSPATSGEAVSSFAFSDEGKSMLLVTNRKNVMKYDMNQNSTLRISSLTNPRTESRYSRVHTPPASDDEAASVFALSCSDHGGVLLCDARSNAIIHHFQMNAVSVGVGFHYRAGVVITADKDANIYEWDLATGRCVHKFKDDHSLHLTSFAISPGAHEEFSRHAFVAAGSQMGFLNLFPLLPGAAEGDEERSCIKRALLKSYGNLSTPITSIAADDSGKFIAYGSEHKKNALRIIHNPSGCVVGNWPTENVGIGRVTDMAFASRFSTLAVGNRAGRVQFFRILTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAU5</accession>
    <name>A0A061DAU5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <ecNumber evidence="4 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0211860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IspF family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="4 8"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768230.1">
        <property type="nucleotide sequence ID" value="XM_012912776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAU5"/>
    <dbReference type="STRING" id="5866.A0A061DAU5"/>
    <dbReference type="GeneID" id="24564585"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211860"/>
    <dbReference type="OMA" id="LIHAIMD"/>
    <dbReference type="OrthoDB" id="2015434at2759"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="entry name" value="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181:SF1">
        <property type="entry name" value="2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="IpsF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" evidence="9">
        <location>
            <begin position="61"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="23050" checksum="A29DDCBD7E7F60B5" modified="2014-09-03" version="1">MAAGTLSHIIAIIIFYLGASPSSFAFHIRASQGLYVNPIRNLPALASQGVSDASRLASQYRVGLGYDVHRLVGPNNGGKAFKLGGIDVEGSGVFVVGHSDGDAVLHAIADAVLGAVGRGDIGEHFSDLDAANGNLDSGVIVRFALSEARNLGYRPCNVDVNIVLQRPRLGSELKRRITARVGELLGPGVCVNVKAKTNEGLDALGRGEAVACQSVVLLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV1</accession>
    <name>A0A061DAV1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769977.1">
        <property type="nucleotide sequence ID" value="XM_012914523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAV1"/>
    <dbReference type="GeneID" id="24566332"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402790"/>
    <dbReference type="OrthoDB" id="366457at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="124" mass="14322" checksum="6A1B6067ACAEF73D" modified="2014-09-03" version="1">MAARCVSMLRRDVYGHRLTWLSQLNAPSRLTTPPMEGLYANTYLKCNSMPDSSPIARLALGPLFANCSILPPSVPLLLSHRDDLRREQFNRIVGKIGIRKKDAGIYWNQYKTKRIKIRKRRRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAX0</accession>
    <name>A0A061DAX0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767046.1">
        <property type="nucleotide sequence ID" value="XM_012911592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAX0"/>
    <dbReference type="GeneID" id="24563401"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="11073" checksum="F74034ADD3F7963E" modified="2014-09-03" version="1">MAECVTRYSPSKCIGSSSQLHLSLKCTTYIVSLIIFSLFYINVTFKCDVNTEPQILTLTFKSHSCTLGKLLSCVLHNVFSSVLTCSQNSMSSLPKLKIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB11</accession>
    <name>A0A061DB11_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0402230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769919.1">
        <property type="nucleotide sequence ID" value="XM_012914465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB11"/>
    <dbReference type="STRING" id="5866.A0A061DB11"/>
    <dbReference type="GeneID" id="24566274"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402230"/>
    <dbReference type="OMA" id="MRYLMEY"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600755" description="arginine--tRNA ligase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="13">
        <location>
            <begin position="630"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="413"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="753" mass="82963" checksum="D3F02D3D82442C58" modified="2014-09-03" version="1">MGCRNKTAVRRLLILVLSALPFVVAFKYNADLKRGFTTLETIVKRGAERLCDARADDILRQCKRPLVRLTVDAWEGDLHTKVTHAIAEQTQLPVDEVAQRLRDEIRKEDDSVGNCIVTGNGYINIFLKDEFLRRLLNSMQCSAPRRLNVPCMSRDAVVVDYFGPNVGKELHIGHLRSAAIGGAVANILEFCGAKVLRRNHVGDFGSHSGQIMRYLLEYDPTSLDAFSPSQVDAERLREITRQQIGYSLWQYKKMSTTERLAQPTPAVSAGLIANTVGEIYQRARTKCEEDASFMARCKEETALLQRGKDTHQAVWHNIAKTSMRSHRDVLKLFNLEKVRDIPESLYAKRVFALVERLIGAGHARRRADGSVTIVARCASTSNEDAVGGGAAGQGGTDDDDAVTVNIPGISNTARGYASESHNVNEASRTAASDGDCTPMYDSEGVDTPNTASSSAEGRDAAGADDSLAREENELVLITKEGYATYLAVDLTALEHRLRENKADRVIYVTDNAQKTHFEHLAVIAKSVGILTTQRVEHVGFGAVQNADGKKMRSRTGSGPSVLDIWQDTVDRCTREVQRKGEYLGPAGEHMARKLASGSILYADLSAAQEARYTFSADRLLKQGGNNLISILYSFVRCRSILRKLAEMGVRTGEDAEVIAEGVPFANEASRKLALQLVGLENAIYAAASMREPHRLCKYVWALSRKFSHFYQHNRVLGHGGSGVNMEAVQLVDLFAKATQLVLALLNIQTLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBA3</accession>
    <name>A0A061DBA3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0201820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767211.1">
        <property type="nucleotide sequence ID" value="XM_012911757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBA3"/>
    <dbReference type="STRING" id="5866.A0A061DBA3"/>
    <dbReference type="GeneID" id="24563566"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201820"/>
    <dbReference type="OMA" id="YQLRFYN"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="122" mass="13983" checksum="8C53B1CC3865E581" modified="2014-09-03" version="1">MKALKSKSQVKKAPVGQKSKFMLDCTAPANDNIINPSGLEKFLQDRIKVDGKTGNLGTSVTVTREKNKIHVTAEVPFSKRYIKYLTKKYLKKQQLRDFLRVVANKENSYELRYFQINDEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBC7</accession>
    <name>A0A061DBC7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenylate and guanylate cyclase catalytic domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0301140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768395.1">
        <property type="nucleotide sequence ID" value="XM_012912941.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBC7"/>
    <dbReference type="GeneID" id="24564750"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301140"/>
    <dbReference type="OMA" id="SKEDECM"/>
    <dbReference type="OrthoDB" id="354346at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1165"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1392"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1423"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1458"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1488"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1524"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2030"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2069"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2101"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2148"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2188"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="1602"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="2264"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1965"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1965"/>
            <end position="1975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2454" mass="275847" checksum="302819BE25A4515B" modified="2014-09-03" version="1">MMDSNNDVSNYPANGVVTRVPFYRGGNKRRSGQRYDGRHIITSYNKDELITKRQNLCFGTKLQPEWESRCLKINPVLSDDIHRFMGNEQHTQRWALAKHVFLIICSNAKRVPYIWGAVSIILNIISPVLLRKGSPKLSWYSHGAVLLTSFSISFLTSGFDAMKRFVVGKCIDFKRCHVLQTGKPRLKKVRVCDLVVGNIVKLTCDEQVPADMIILACSNPDGQVHIDTTFVDGKRDLKVKVCTKDAKVEASVHSFANIRGQIVCDRPSADLDSFVGALRLKGHPRPKNLYIHNFVMKGSIIRNTGTVYGVITHTGPDTKIAQNIKKENQCIKSGSVEGLINHFTVIVGCIYVLCLVVSMGTRWSILLASDRRKKGTALVIESLLFVLIRFFLLYGGLIPVTLPAIVDVLRYACSTIYDGHTDYSFFSDVHVRGQTLQHAPDTTTVFPVTWPMTSGLLDELGLVDIIFCDKTGTLTSNDLKASLITVGNKTFDTSGDRTSIHSKIENELEQNPRFDTLMKLMCLCNASVPVTSAPSLEIFTSPIRMTTSSSQGLKHSASGNSDISLGISNNNQYPLRPSKSRIHFGNVSYIEPLNSLNFGLKDMDSMNNSMEFGGEAAENEGDSEETYATNAFPHRPSRSNQIYYRSPHKEDECMLDICREFGYKLTHRSKSHINLEARGLQEEWNIVGFNTFSPERRRMSMVASRPDQDGSTIFVKGSADTMMNLIRLTTEDEHRDMSALSIRIEKLTTAGFRVLVCAYRDLSREETQLYQRHFTNAEDSVYSADTLHEEAAIMVERRLTYLGFVAFKDELQAGVPETLDLLMEAGIRIWMTTGDNRHAAIEAAYLSKLLVHPCRIFDCKLPTNKLDDSPHKDCGALYEAFLQQRAEKTQSEQICLVVDGKDLKDFLTNSTMQTYFVNMLCFADVVLACSLTPCQKAEFVRLVRVRLTPTPVTLAIGDGLNDVKMMQEAHVGVAVLGSTPDAAAYADFVTTHFAGLRSLLFYQGSNALQIIAIAIYWSFFKSLCLVMPIFYYQGHTDWVGLDLYGSFVQLLFHLLFTAFPVTFCALFDRPLSEPMSTNLPILYTLCRRRFHVNLLRLGFWILEGILSSIFCYLSIQTTTLESPIFSGGGTISARTFGLLCSLGTLQMSNTRLLMESFTRNNAFGIVFTLVFIFAMPPSFLGLCFLFGGRILRNATLQVALWQPVYFLIPVWLGIGAVFHVASALTQALVSPNIANYVKHWVSTQMCYCAAQSNNPSTTESSKSVGTSLPTVDGMVQNVRQVHNWCDHMLQRVRKEFNIHGMDSWIRMIPAARPFRVREGDLSVTQPVAITSSSSFSKDNIEEDLHKQQSDVNVQNQRASYLIDRFTLRFKDMQLEADYRLHKRRNHYRTNRIWYRTVFLAIGLYYIFGWILDYLIKVSYNQETAIYTILPPICVTALAFGCAILTFHPTHFMHHINKVLGALVSCMILQYVVTLSLMEPLSSLQPILFPIFTFVILHITFIYALLANAIFVVSTIRSVDKSIHTVPLFIGINVFVAFVGYRLEYNNRKNFLFEFSARNARKKQSELLNTMLPNFVVSKMINARLNEDGIPIGFEAEEHAVVSVLFCDVYHFQNLVATVEPTTLVELLDSLFLAFDRCAEQFGATKIETVFETYLAACGLSRGIAPCPYESAANAIDMALAMMEASKQIHYSYISECHDGSYMEQSESVLVKIGINSGKVISGLVGAKKPQYALFGDTVNTASRMKSMGEVGYIHITDDTYNLVKADSTLTFSHRETFVKGKGMMKTHLLISAEGSAYPNFESVDTCGTANVYRANTSDEMGSRDVPVAKIGEGIVDHERGARNKSPENNNILFECLDKSHSLNISDDICLRSSVDTAIPAVAHANDYERSCSRKLRISAAVGALTEEDDGVFLKDQPGLLRHCSMYSTGAASTNSVQSRASRCLNFLRRANTMALRHNTLSASSPIHSSSFTRQNAQDEDDEINSGIDGSDMRMKTKEWIMLKFTDKLQEDRYRSHFYHNRANINTIEQTLVIFLITFVAQSILEIAIPRSFEDDSNMERLLFIKYVQYWTVRSVYITLVFVMWLLFHFNSFSRRSESNTTMWLTFFLNLLFVSAACIFALSNSWAVAGSGVYSQYLNLWLPSDSIEFYFYIVVLHHSSGMLFQTCLLVDTLFVIISMTFISSSVVQTATTSITLCSIPCYIVFNLISAHCKEAIDRRAFHSNEKARMIEARVGQMLNDMLPKSVLEEFKSDKLKMSYCHEKMSFLFSDIVGFTLWANSVDACEVIALLQRLFARFDRNSTKFGLYKLCTIGDAYVAVSEPAIEVPSDQEAIANIEGILQMAYSMIRTIQDVREAFNIPGLNMRIGLHYGCSVGGVVGSGRLRYDLWGMDIHTANAMESNGIPGKVCVSERLKLILMTNFPNRFDFTFNNDIQVIDRCVRSYILTTDSSDSSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBG9</accession>
    <name>A0A061DBG9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L34, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0405350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770237.1">
        <property type="nucleotide sequence ID" value="XM_012914783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBG9"/>
    <dbReference type="STRING" id="5866.A0A061DBG9"/>
    <dbReference type="GeneID" id="24566592"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405350"/>
    <dbReference type="OMA" id="RCHKCVR"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR98051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="159" mass="17886" checksum="B2404D32CDD68D1B" modified="2014-09-03" version="1">MAQRVVLRRRCRYNTKSNKQRVVKTPGARLVVQRRTKVAQGPKCGDCKRRLAGIAALRPHLYRNLKKRERTVSRAYGGVRCHGCVKDRIIRAFLKEEQRALKKVIEAREATKATAAGKGKEEKKDAAKKSAKAPKAEGAKEPKEFRDSKAPKRKSAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH3</accession>
    <name>A0A061DBH3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770242.1">
        <property type="nucleotide sequence ID" value="XM_012914788.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBH3"/>
    <dbReference type="GeneID" id="24566597"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405400"/>
    <dbReference type="OMA" id="KREWDRW"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="197"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1451" mass="164588" checksum="86C9E15AD9A77AA6" modified="2014-09-03" version="1">MHWYVDQEAPDRMPPISANEVELVVSDFRGKVIEPLSRLLKEGDPNEEIRRLQNLTVFSEWKDIPNFRFRIMFFPVSPQPEGDSGIQEYHISAYVEGTAKDDWPENWVCYSTRFCVIVLNHKDVHLSVYKADSFNFSSSEADRGWQGILTHTQLVDGGFLNENGDLVLRAGVYPIGAEVNRAAREHGYDCRKATGFVGLQNHGATCYMNALLQSLYSITKFRKAVYSLNFRVDEMIGEQSYEIMKRLQSEMRDCHPSEVQSNNGYKNSKRKSHEHSEFNNEDNEGSADNSDLFVDSNMDERDCRAILMEEEEEQKKVPSVGLALQNLFYKLRYAQHAPPCKELMRSFGWDSSDMFTQQDSHELLKLLLDKMEEQMKGTPVEGSVKQMFEGEMETYIECIDIDYKSSRMETFEDIQLDIQGCSDIYDSLKKLTEAEILSGDNMYEAEGHGKQRARKGIRFLKFPPVCVFLLKRFTFDLQRMDTVKLNDRFEFYKEIDLSPFCPTGGQYVLQAVSVHHGSINSGHYYAFAASDKRQWHRFDDENVAKVSEYAVIGDNFGGEEPDCYNYCSAENESSPRPSRRTKNYNAYILIYVLKSAAGDILGDCDPVSEGYSMITRCCMQDRLAAMRHRVRERLSQSIKVKVFEKSDFEGLKFMDQPFMGWLGGKVITFDRSTVLSEALKRIGNMFAKPDTDVYAGPENFHVMGINRSTHRFCCLAEVRGHQEVSDDTLQSIVSQIRHDVFQVYDPTLYILYVPRPMHCASIQSSSLFFIKYFDIFSENPDGERLICIDVVYLSPEGTILQVAGPALCKLARFMTEGLITPYHVSAIERCVSRIGSVDMSSKSVREMDAILNQILHEESLHLNWYVEQSGLYEAVALNKTLKEQHLGNGDLLVFNFRPTESMRRLVEEIDTKFTLKEDFVETRPVLEGALSGPLFHVSADYLQSGEAPGASISPHTIAFRDMRARWESFAATEILKYQSVNMFPIYDFPSFIDWRLNVVTITFELYNPFEQLGAWVNCCGSIVKAVGSVDDPSPKSFEESPKVAGPLKTVQFTLDLRVPCKHALRYVCWSMGVDPAHVLFYAHQPHKLESIWMRPASIDDFCHRDGSLGFVQKPLSNLFTALGKAVRHDNANRDAVMRSGSINSNAQCSDHSVDSACQTDISAASGTGNANGIGNVLALPNRTISGSDTGILDSGRDTGREEMMGGVPLANSLNSRFEGGSNKPNVIYMAVFPQCYSDLTVKCDGVSLNFVVQVFNRRVECTGVCMGKAPAGITVGEVCDMVVRIANLGPNVRMRMVECLSDSFVVVEPSGLMRDLPHYVNTNIRNILAAPIRVEPDWSYEEQESLKNGERVLLTVMHQTPDHETFGHPFQVLVHPRWTLGEIKGAIREKLCLPKREWDRWSFFQQMDGYNRAWKANDDCLDWDKSSDIKLLAEHPKPYDKSRSFSAMRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBI1</accession>
    <name>A0A061DBI1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein phosphatase T</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0403910</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770089.1">
        <property type="nucleotide sequence ID" value="XM_012914635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBI1"/>
    <dbReference type="STRING" id="5866.A0A061DBI1"/>
    <dbReference type="GeneID" id="24566444"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403910"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000036">
        <property type="entry name" value="Serine/threonine protein phosphatase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 17" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="17">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="19">
        <location>
            <begin position="220"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR97903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="514" mass="58142" checksum="81249BD357CAF77C" modified="2014-09-03" version="1">MDVPEDSGNLLIAEAQQMADEKRLEGNRHFADADYSGAIEFYTHAIHLLRCAVEADSDAENGADEGSYASLYAQTNIHQLYTNRALCHVRMENYGLAVLDADIAIQMQPGYSKAYYRRGCAYLCLMKFKEAEKDFAKVLSIQNDALTRTKLMQCRAMLREKQFQEAIMIESPPPLHMTIDVDAIRVDDSYTGPRYTPEITEKAAFYNEVLDYIKVPGNILHRKYMMMLILDVIRILKKYDSVVDLSLSADEEITICGDIHGQFYDLLNIFKINGLPSETNGYLFNGDFVDRGSFSVECAIALFLAKVLYPTKFYITRGNHETEALNKCYGFKGEVLSKYDEKVYNLFCECFCYLPLGYVINKKVMIVHGGLFGEDGVTLDQLKNVDRVREPPDQGHMTDMLWSDPKPTTGRSPSKRGVACEFGPDVTANFLKANGLELLIRSHEVKQEGYETEHNGQVITIFSAPNYCDQMGNKGAFIRMNGKDCKPVFTQFDAVEHPPVKAMQYANPLFNGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBP7</accession>
    <name>A0A061DBP7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769558.1">
        <property type="nucleotide sequence ID" value="XM_012914104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBP7"/>
    <dbReference type="GeneID" id="24565913"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312750"/>
    <dbReference type="OMA" id="WLYYEIF"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113527" checksum="5FE5B49B2EB42FB7" modified="2014-09-03" version="1">MFGTAWLSRLQLRSAPSLRLPFNPGRLRVLLPRMRLARLIASVLNREWLLTIIGALTLALWLYYELCYVALVCPYYTGSELPSLLDKFRTIGKTYRPTFYMFAPYCQWMYLSCFCKITRRYRILLDTAAEASSLSISFCAKVGSALLRAVLRCFLFRRIYRDQAEVTVREFVEAHNGAVVVLDYYLPRWATNFCSSCGKFKQQSCWWAGSSRTKAATAGSAYPQTTDEAESSRRVVNTQLEAPNLHEIRAHEGAHQDDVRRAEVARDVPLQVSKDVLKSPNLDGSARSSDRDEPLDDFSLSGKPVPPSDARNAEDVVGPPRKLLRGVIAVIGDVSMSYSVCNQALNCNCGQPVTSEEETEQFACTGCETSGLEDSKGLNLDPPGLPVVRCLISDALEIGFACVQIHLNVNLGMASEAFPTWTGLRCFPVSLYSDALLDLNSGLKRISERYPSLPLCCVGVGFGSNILMEYMSLGSAGKAVPVVFDPSQDPQKLLINMADRRYTMMRRGQSTDQYDSNESRSDSDTESRVSRKSIERRMAQPVAKAPVEVDQDAPEQDSGVSSSARLPHTADSLASDPRRMSEPVKAVAGHVFSPPAHSMTQDMQQILQNPDDPNYESFAYLSQVIGKINASNSATPRPVPSAASANSAVVTPREGHFGFDEEAEECTYETSVAYPPAQEREVVFDTKRISAAVCVNLNLRTSGNALYKSTRQRQIHNQSMYIRHCFAAFKHHLIALVREVHCHRANGSLQKECYLYRCCHYTRAVARQPWSRRVLLGLRQPIEGFHTVARHYRIEHLLLAAHREYRMSYRHMRRRESGEYVNYRAGIFKRFGARAAMDFKLCALMTLRYVYSHTGHDNRGRVETLSGNPTYKLVNKRIDTNLRIGRAHFYGGINKLINQGSRRPQDPKVHKYIAELINREYTRNVANIRRYFTAITLPTLLISSLDNSMFSWEDVDIFDVLKNPNLVYYICKSGGYATFLSGFFPNTWLSRPVLEFLDEMSSRRVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBQ0</accession>
    <name>A0A061DBQ0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0312800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769563.1">
        <property type="nucleotide sequence ID" value="XM_012914109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565918"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312800"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1727"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1802" mass="201037" checksum="CD47604BDBCBD88D" modified="2014-09-03" version="1">MITSWRTTKPSGSSVDGPESGTAQAVDKAIDQVREDVKGIDGKFESDVKQPLDTAVKELEGAVDTFNEQAKQQVKDAAKGAIDKAANVISTQSGESKIDLQKTMPNFHNAHKEITTNLKPKLEKLLNDHIGRDDTSDGKKDQVKLSKDFKKYDKQVYIGSITDKVYGPLSLAIEKVRDEGLMEINKHVGKRSGVGPAITDKQITDSFKAIKKQLEGIVELVSDRRIGYLGESINNSSGLRTFLKQLQESLGDKQLGDVKGLDAITKVIAEVQKGTLEAQPKAIGEAVTAIKLELEVLKKKLISDSDSDKSPVINALRDLKNTGLASGTWNGKGGSPVDGLKKIQEHLKDQNEELPKQTKLIDAAIDDIRYELFQVGIRLNHKNETDDVIDQLDWLRRKIGISDAKPGNLLKIISEISRLWAGKFSVNPDKIALTINTIKARLQGLRGLLEGDQDNDVIATLKDLKEVGLSKNFWKKNENEKGLQLIESCLKYVQTTVSQQPREIELGVEQITKELEGLRTALKDKHGDPNNDVINQLEILQKNGLGADDNPWKGNASGLGKIRSKIQGQNAKLAEASDNIKQATESVLQETETLLKSAKHKLSPDLIAEDGVVQNLKTLEEMIKNSGGITNNNLKDIYDTISGLQNQAFKNNPENIGQAEREIANGLRKLQSELDGHVTNPLRDVIQQGLGGGDKWNGHDAKSFDHIESNLERQQRVLTDQPEIISSGMKEITDELQSLRTELQGTDSDDPENRGVIRNLQFMTTHIGGSDKEGIKKIKREMESLKNDQGKDITKHLNIMSSAITNAAGNLAWNLGELENSHIDGKLKGIQDGLDNLRLTELAEAIRLCDDFLRDADEIERNTIADHWKHVDDEVDDGIKELTKEARRLYVDSVREALELFAKKVTEDLEQLQNEINRDRYVGYKGFMRYLQGPLSSDLTGDEQSVAELSSAFQEVFEQIKKYVAGEITRLHDEQNKEKNPSLPPTEEPYTPKLNDVYEVLTELLAYLKDYDDGADRLTELVERLTKALSNLVPSDFKHPSTPLLDTVSRGLNKFAAEFYNTYISAYSGQRCREEHAHKYAKVLLSRIPMTYNALTKLATKCEGEWKPLHISMLTTDDRDNALGNYLTRCGYRVSSNYAVQQGELRCDMLGGGIYELLVSPIPDVSIELMVDGEPIKNGITLYHIISLLYDALCNYFQACHIYVPPKPRYPCTVKDMLSWLSGLQYTRIADNLPDHCKALLNRRCHDGDTPNRDDPIMGKCIESLPYTIAATCSRSTALLTVIQGNGHGFDLAAYPYSVDFSNNRARLHYPANPAELLDMLRDIACRLCKVLYFLYSQCCRSTTRVGGWRECTYGRQIQSHNWQCKQFTTYSSISTTAAATTTTSSTTTSNPGCPHTSPLQSFLSDSCHGLLPHTLTAVNMAIDCANCKANEFGQQCLTPLGFWDLGFAASITVTGWDLAKRLGDMCRDADACLFVLYRTLSLLCPTAPSSLADVFALYAQVLRQWDPHDRVEHRGGTYTDASDFISHLNTDGIDSLFPLWTQLHGSYDNNTLTTAISSLAGHDHKSHDALSSLLNDSTCQSPSGCTPYLQPLGLHAHHSYPKKHAVLYITWIMYLVWQLWGLLCDLLHALDNIDCTASGCATCPCQPGTHGGKDTCHCPSIVQCAGPLPTLYRYGFTYRNANLLVTDNYAMRCGDLNTQLKQALHSGHFTELFHQIDQLTWHIRMPFLHCFIALWSLVALYILHTFLHRMDVLYIRSHLMTTKASHLIDVKALLIPSRQMLSLYDASYFDDDPNELLNLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBS7</accession>
    <name>A0A061DBS7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768505.1">
        <property type="nucleotide sequence ID" value="XM_012913051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBS7"/>
    <dbReference type="STRING" id="5866.A0A061DBS7"/>
    <dbReference type="GeneID" id="24564860"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302230"/>
    <dbReference type="OMA" id="NEMNTRE"/>
    <dbReference type="OrthoDB" id="364745at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="288"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="388"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="577" mass="67968" checksum="561345FBF13F6B3D" modified="2014-09-03" version="1">MMGNYEYTTDTRRMPYDDDRRTDQTNYGADMRDSISSMGPRSGYARTNGVTFHDSVECVCGARQHMQRLQQDIKRRGKQIDQDQSKVRHRFDELKKREKKLNDLERELLLREEEMKSYKIYLQDKQHSISQMQQQNDAAQRELLQRLDECAALEDECRRRLAEYESGLADVGRREAAVNETARSLNSRKDEIDRVEHTLLIETDRLKEIRDQCAEAREQVAQEVKQHRRRMEEEIEEAEAQKKKILEMENTFLDEKAAFDDYVRAKKRELEHRIKEVTDSNDASEAIANDLKKREEVLNHDVQRLQTEREEMKLAREKIKAEWDKVNQALEEIRNAKSELKSIKRACTKQKRLLDDEIENQTRQLQTSASEQFQYNQSPITHEAYLDIKQAEIELQTRAKQVELAAEELKAKQMELSEYAAQLKQRELTIKEAEHKLERYQDALDAREKELEELQAELMNSRNMSQQQEAQMQEYKEQMALLAIERNSLEGQKAQFERHRLAKEAELNAARQRLERKEQELDEKIAKYRGIKDSQHLENRIEGIRAAQPSKKSANRPFSIPPKNGGASHSKYSDRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT2</accession>
    <name>A0A061DBT2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768515.1">
        <property type="nucleotide sequence ID" value="XM_012913061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT2"/>
    <dbReference type="GeneID" id="24564870"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302330"/>
    <dbReference type="OMA" id="TTQPMWQ"/>
    <dbReference type="OrthoDB" id="407535at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="257" mass="30246" checksum="C2F25F97DCE8ADBB" modified="2014-09-03" version="1">MIFAGRTLARAGLKGRAVQYGCRVVAAQRRHRHDGNAGVYEYEPSKNPWEDNSYHALKKDIGHTGWPILVATNTTQPMWQSYTWGEHSVIPRDGYGCPGTFPPEVSTKIRHTFRLPPQFYPFLKKLADDTPELKPYMYRLIEGKFTNDDYEEMFYKFAKPLKIYRKLIPKPYRTAEEQAREPEVSWESAWLSYRQRVAAEYNMAINMREYLMGMLIAVFGANLWLQMHKQYRADMRLYYHEAPEHKVNWVVPRGDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT5</accession>
    <name>A0A061DBT5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Microtubule-associated protein RP/EB family member protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0302380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768520.1">
        <property type="nucleotide sequence ID" value="XM_012913066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT5"/>
    <dbReference type="STRING" id="5866.A0A061DBT5"/>
    <dbReference type="GeneID" id="24564875"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302380"/>
    <dbReference type="OMA" id="HIIYARE"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="13">
        <location>
            <begin position="326"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="292"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="393" mass="43333" checksum="8B2B900A1F622C1B" modified="2014-09-03" version="1">MMQRSRGSAAASPHRGLDVNPLVGRSELIAWVNDTLGVTIERVEQCCNGAVYIQLLDVVHPGRVPLARVKFGAALEYEYLANYKVLQIAFTKLGISKHVDVQKLTKGRYQDNLEFLQWMRGYVESHRTVESSEYDGVRRRVTAVIRNCIANNSNAHLTLGSVTSALPAWAQEGVTVPLIKECLANVKASATTNSQDGAKPSESRENNVSNRQGSVDPKQVVRATRSAASSISGRDAKIRRITSSNGSKSQQSDASSRTSTADTHVKESDAGAAVSRCASVETSLPPNHTDLLDAERHRCQELESQLKSQKQQAEDLRSSLDERDRTVAALQEQVDSLKKQLGQLQADKQVAKMSKDFYYNKLRRIEILCQKCETGQIEVAPLFDVMYATDNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBV9</accession>
    <name>A0A061DBV9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0302730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768555.1">
        <property type="nucleotide sequence ID" value="XM_012913101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBV9"/>
    <dbReference type="GeneID" id="24564910"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302730"/>
    <dbReference type="OrthoDB" id="10605452at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="116" mass="12818" checksum="A3759E910126244D" modified="2014-09-03" version="1">MQAPTSGARAYSQEALEKRIQHLAEAAAQLASTLPSVSHGLMRQALRHLKDANGFRRAHAKQKKDKGRLMQQTHVISHKTVMSYECQLCKARTTFPGALRTIPINKKAANKAKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC05</accession>
    <name>A0A061DC05_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centrin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0303380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the centrin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768620.1">
        <property type="nucleotide sequence ID" value="XM_012913166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC05"/>
    <dbReference type="STRING" id="5866.A0A061DC05"/>
    <dbReference type="GeneID" id="24564975"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303380"/>
    <dbReference type="OMA" id="YMDVDEL"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="166" mass="18573" checksum="6BCB6458B444DA60" modified="2014-09-03" version="1">MTIGRRDYGEAAAAGHTGLTDDEVYEMQEAFNLFDTDGSGTIDPREIKCAMQSLGIDKKNPLVYQIVADLEKSGSTQIDFNDFLDSITLKLGNRDSKEGIRRIFNLFDQDNTGSISFKNLKKVATELGEFISDEELRDMIHRSDSNGDGLLSFEDFYSVMAKRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCD4</accession>
    <name>A0A061DCD4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0402220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769918.1">
        <property type="nucleotide sequence ID" value="XM_012914464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCD4"/>
    <dbReference type="STRING" id="5866.A0A061DCD4"/>
    <dbReference type="GeneID" id="24566273"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402220"/>
    <dbReference type="OMA" id="LEWAENY"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="130"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="225" mass="25264" checksum="984AD6A7D4BF1447" modified="2014-09-03" version="1">MPKSKRSREVKLTAVRKHARERKMALMDAVRAAIEAPLDGGERFVYLLALHNQRNSPLENIRQILRPGRLFYGKNKVLQLALGAKPENELQTNLHKIAERIVGERALLVTTEPPEVVKSKLEGYRVADFAKAGSAATDTIVLQPDDESLDVFPGNMEPQLRQLGMPTTLNMGKIQLLGEYHVCEKGKPLTPNQAQVLKMLGIRMAVFEVTLDCYWADGHFRRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL4</accession>
    <name>A0A061DCL4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770038.1">
        <property type="nucleotide sequence ID" value="XM_012914584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCL4"/>
    <dbReference type="GeneID" id="24566393"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403400"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="8147" checksum="8AF83F37D3E65917" modified="2014-09-03" version="1">MDTDYANDARPPPAQDAWIILASYVRQTWFQLTGRVPALVSSDNDIQVLFTLLPFALVFLLAARVKSPRHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD09</accession>
    <name>A0A061DD09_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768041.1">
        <property type="nucleotide sequence ID" value="XM_012912587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD09"/>
    <dbReference type="GeneID" id="24564396"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210080"/>
    <dbReference type="OMA" id="THYEKPE"/>
    <dbReference type="OrthoDB" id="363195at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596230" evidence="1">
        <location>
            <begin position="22"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="452" mass="50301" checksum="25905428EB356454" modified="2014-09-03" version="1">MRRMTPILALIATHTVCVLHAASVEHVHKDDGRLEDLFSEAFMMIQEITDGSEKQKLAFSRLLTNVAATFDVEGYRWMLDIVKGRRATERFTQAVAHRSFSQPHCDKGSWVSPSHTFGDLVKFPGGPFRGGTGYDLVRWMGNQYSHVHSPASANQPGLENMIVQAFQQIKGVIQTILAVVVDLVPPIVISVSLPCLPMLTGINCLGSVLYPISATDFVMADITDSVMNGVISSFPAKYAAKVGRTSDAQYYFCAHIYLGMYCASLFPICVTGAAKIAETFPMCFVQCIAALIACPGFWMDDIAVPCSNLSVPPFCSFSVFANHYRIPPQYTTYDQSHMYPEGCPQYNPEIDTPRDLYDKKAAPPSAIAKAAKEKPLEEFHLKRRKAEEFPGACDCDAIKEVCRLHLPYPVYVNADPSTSETHYQVPERVDEHEKRCCEECTPIWDITENNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD47</accession>
    <name>A0A061DD47_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769280.1">
        <property type="nucleotide sequence ID" value="XM_012913826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD47"/>
    <dbReference type="STRING" id="5866.A0A061DD47"/>
    <dbReference type="GeneID" id="24565635"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309970"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1269" mass="139076" checksum="8796913CEEC191F0" modified="2014-09-03" version="1">MVIQKKSTILPLKTLKECLEFLKWLEVNKEKQEKVAKKLERRINYYYSKKVNVENIKSALSNFIDQASHFYGKICRSKQPHKHGLRKDKDVLDTLLASIPKLLSVRSLLEYNVDVRFQNIGGGGWKDEPIGSFIVSTSSVSKIDAYLTEKNINKYGVIPGGFEKGEVNDAAHGAYANGSVMANDFDKFFDQQEHQLFRDVFATSVSTTVGSQTSNSANALRLLKIFCDIVETELNEELKNYLEAHRVCIDWEELKQHCSGLRSKLDTLFANGRFSHTGQAPRNEDLNSKHFAKKMATWLRDNLDKVRGNLEKIETNDHVLGNTQPGQLGEYLKKHFFPYGFTFHGHNIDTESNLKHVLKTDWKAVIGCLNEHNSGLSKLVHILKGKQCLLKQSQKAAVVQNHDSTADPESESDPEEDEEEDDDDDGGLTYQNNDQSVQHPGLPNEANYSDTPPEDGKGQGPAGALGGGGAGLQVSGPPAQQPVPPQAAAPTSSTITPSPGSSSSGGLGPGGGTGAPGSNGDQGKLGPAGPVVSASSDVSDAQVIQTSQPALQSSPVSSLTPPASPPGSPKPTAKTGVLGGGLQNASLGSDPLLAASAVLAQPSSVSGPPSVASGVLSTGSGTDIPDIETEVVIHPWEGGKDAYNTHSDALLNDHIERLRDPNGINLLNGPITHRGTVREASPQSDIASDLDKLQEASVLSNSLGLRDVDMPFEHFDFHVSPNEGGTGEVYIPQCLNPWYVDPSSTSTSHSTTSPPDSDNMPSPNTVREMLYWMVGVVELGYIGFIQKHVGGVLDDINKDSSWPSFAIDVTGYPNQLTASRVTNTLAEACLYSANIITRIKYYNDFKAFSTVDFKSVYSQLHYSSDPSCLLCQLRDYAYACHYQLQFLKSQCNQDKSLGGWQNCNYGSDISSSNSLLQSFLTDGWDSDFETHPFDPCNICCKTRVHMGFKHKDLPKPHQTGATLSTILTPSCGGDDPLLTLSSYLNCLTRRTPRTTGELVSYFHHFGNLMYDASSKGLSNLGKALTKPHENCPDWDHFVDSELPAIRGIRGVDSANHNVDHAGSLSKLLGCDITNAQCAKLLSPTTHRAYAVYSPCFTHTYLSWAVFLSDRLWKSFKRLLYDLEGHDNTKCSSLHSCPYAMPLLYTHGFMPPEGKLQWPLTCSDIIVKLRTVVDGKPIAMLMTCMDDFLYRVRMPFIYTLIALWSVAVLLLSYTILYRLDVLYLCSHAIRSKASHLIDVKALLTNSRKMLSLYDADYFDDDPNDLIDQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD67</accession>
    <name>A0A061DD67_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769330.1">
        <property type="nucleotide sequence ID" value="XM_012913876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD67"/>
    <dbReference type="GeneID" id="24565685"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310470"/>
    <dbReference type="OrthoDB" id="10346368at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="27886" checksum="FA13C6E2C83D03D8" modified="2014-09-03" version="1">MVYTSLTEAPHNLKEAIDWLMAVKGTDGENNLKALGKAVYDVLADKPIGKAELPALEKVKPIAKKFLEHKDLKGQWFVRMLMDRYNRPLNRFTNRVVKSMIYITDSDYKDAIKGQRLTAGNIGKKIGEVVDGCGKLLDGVKNHDKYKSAYSSEATWDASCSKDPEACAVVLVGIAPVLFVGLRSLFDAVPGRIFGVARPKAKGNSEKILTAVGYELPQRRSEILGAELLNALEGVSTEVLTTIYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD71</accession>
    <name>A0A061DD71_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768196.1">
        <property type="nucleotide sequence ID" value="XM_012912742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD71"/>
    <dbReference type="STRING" id="5866.A0A061DD71"/>
    <dbReference type="GeneID" id="24564551"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211540"/>
    <dbReference type="OMA" id="NYMSKDI"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="957"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1107" mass="121057" checksum="B77CBE42F3F76C6D" modified="2014-09-03" version="1">MALNPILAQDIHSKQLIPHCQNGEYLLMCRNSTSFTLSLQGRSMKGAGDTFLTTHRIVMVKKQDQKFHKDFSSISLPYSHVDEPRFRQPIFGSNYLEGSIRPDSVAPYPLASAGKFYLYFDGGCGNFLNGFFMYYARVRNNPAYRVDAHPMRDMPESRSAFVDPNDPTRVYYAQPEQAPVAPPASAVYATQSGTEPSAPPMAPAAAAAAAAAARAGQADNPTEAGNTAEGETPAEGAAPDPAEENRRLVRRGKTSAATSFSNVSIFGEKCEGSSHSGGDSAAAEVGFTSCAYRDACLHLPALTPFSTIAFYAALVCLPMLPLLGEEASVSEHAYLHGFTPDTLTYASRLFMIETMSSITEACQQGSARSNEQTKGLPPFSRWTAEAPADAPAVYTAIEELVRATIPRAEVAYNDFRYVFNNGLGVTGSSILLHLKCARCSSYGASLVVATIDTGSKSDFMLDQRGYITRPKGGDGEALGRCASSTHGVAAAIAALKNVAEFDNQQQDLMVLITERNLPYAAGTRQFLDDYFTRPDFKWNSGWLHNALALDLGYGRCGSYEVTYEGLDGAVPNPDVVISFLSTAKTAELDAEPADVLARIGRMSMNALPHLPHVAMLPRGISSFTLTCARRADHTDENNAEKLLRVLTPTIRMQNNLDTVLERKSNYYQMVSQDEYLTEASYLPIVPALLLGLTVELLYSGHTWNFHALMAGLAVFAFNACMGPLLSYLYLVKIGGLDFDTLDASNLNKVRGSLVVLLSSYAALLFLNVLALRSLPRRAFVGYVADRAVLVRNELLSKLGYHVPPSSPFARVCNKIVGPLRAFLEKLKAAIHSILPPFIRKAMETARKRGPSRLSLMLERWRARRQGSRSPSSSIEMVPTPEEKPVVADAEETVPDETVVETPTVQEVADEEESQSLLDSMGGTAIACPTNSALPTPNVVAGIGTLFFATVFLYSLMIFHWPLAVLLSLCLVPALRRVRVWNHTRRKCLADLFICTNYLVFISILSSTRRVLNSKQRELLDVAFNTGPLGVLAFVLRAVYRVYLLVRRINFARLVAILRGPFVSQKVLSLAQQHVLLGSGALPLIWFCAVPVVFHIGLIFILTRCNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD82</accession>
    <name>A0A061DD82_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein transport protein SEC61 gamma subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0211820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768226.1">
        <property type="nucleotide sequence ID" value="XM_012912772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD82"/>
    <dbReference type="STRING" id="5866.A0A061DD82"/>
    <dbReference type="GeneID" id="24564581"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211820"/>
    <dbReference type="OMA" id="KPDQKEY"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9300" checksum="36CAE6768CBDCCE6" modified="2014-09-03" version="1">MKLQVPNFLLDPSNPAGYTVRTVTDFINDSTRLVRKCTKPDKKEYTRILRACSIGFFIMGIIGYMVKLMFIPVNNILVGMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD83</accession>
    <name>A0A061DD83_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hsp90 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0310820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769365.1">
        <property type="nucleotide sequence ID" value="XM_012913911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD83"/>
    <dbReference type="STRING" id="5866.A0A061DD83"/>
    <dbReference type="GeneID" id="24565720"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310820"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="716" mass="82608" checksum="D2283C8A1B4FAF24" modified="2014-09-03" version="1">MATEGQETYAFNADISQLLSLIINAFYSNKEIFLRELISNASDALEKIRYEAIKDPKQVEDFPEYQISLSVDKANKTLTIEDTGIGMTKADLINNLGTIAKSGTKAFMEAIQAGADMSMIGQFGVGFYSAYLVADKVTVVSKNNNDDQYMWESSASGHFTVTKDESGEQLKRGTRLILHLKDDQTEYLEERRLKDLVKKHSEFISFPIRLSVEKTTETEVTDDEAEPAADSETKEEKIKDVTDEVEKEGEEDKDGEDKEGEKSAEKKKRKVTSVTREWEMLNKQKPIWMRLPTEVTHEEYASFYKNLCNDWEDHLAVKHFSVEGQLEFKALLFIPKRAPFDMFESRKKKNNIKLYVRRVFIMDDCEELIPEWLGFVKGVVDSEDLPLNISREILQQNKILKVIRKNLVKKCLELFAELTEKKEDFKKFYEQFSKNLKLGIHEDNANRTKIAELLRYETSKSGDEAISLKEYVDRMKPDQKYIYYITGESKQSVANSPFLELLRSKGIEVIYMTDPIDEYAVQQIKEFEGKKLKCCTKENLELEDTEEERKSFETLQKEMEPLCRVIKEILHDKVEKVICGKRFTESPCALVTSEFGWSANMERIMKAQALRDNNFGSFMISKKTMELNPHHSIMKELKQRAETDKSDKTLKDLVWLLYDTAMLTSGFNLDDPTQFGGRIYRMIKLGLSLDDDAPVEDVEIPSLDEVVVDPKMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD87</accession>
    <name>A0A061DD87_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inner membrane protein yihN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0310920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769375.1">
        <property type="nucleotide sequence ID" value="XM_012913921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD87"/>
    <dbReference type="GeneID" id="24565730"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310920"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="470"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="522" mass="57573" checksum="22F8A7CC6A47E080" modified="2014-09-03" version="1">MSEPRPLSTAEHDSSAPAKQAPKKEPVNYGVVGQVLYHVVSFTEGYEQQVLYLCMRLFESTMGFTKRQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSSTSRYSSILFLRFLHGAAFGCIYPVQQKIISDEDDGQSTGSSSTFTRLHALNCIGRMICAAITTEAAQNILLGFIGWRVSYIVLGYVWISVGIAIIFSLKATEELISPYESMSYFIEQMSGAFKAVFTSATAFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDMKVGIAILVTTIGGAAGTAAGGVVIDKIASLHTDYGELIAGIVVMGVRLIVCILFFVSPAPDGRLMWYHYIEFAILGATLVTVGGVDRPIMRKAIEEKYQATASALIQCISGISISVSFVEIFAYVSEKLHGYAPSKQAIDDMDAALKDNNTEALRKSTMYMIVVGSLLNIACYGALFGRYKEDKEIVEKKNEKERVVRQEKKQKMIAEKQGRREEEPITEDRLHELDLSSNTLGERPILELPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB0</accession>
    <name>A0A061DDB0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768301.1">
        <property type="nucleotide sequence ID" value="XM_012912847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDB0"/>
    <dbReference type="GeneID" id="24564656"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300200"/>
    <dbReference type="OMA" id="CKNYINT"/>
    <dbReference type="OrthoDB" id="365997at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="864"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="932" mass="103494" checksum="1898E7E7F16DFF21" modified="2014-09-03" version="1">MLSLRTLPRLIRDVGVSACGTAKTLSTASGGVNVTREAAITNLGAANRDSGTDVATTPLKRAVLMEPATLCRTLVQASKDGQGGKRAWKAHIRKAVEIKDQLTLKQIAIVIHSCTNANVGKEYLRGLIDGLKPAVLPHLIRATATNEVGRVELYNIYSILHGTATAEQNDAELSRALKDAAVAQFRHLHAAGEREPLKPFIFEDVAGIMHALMVMRVAVTDEETKLCHDLFMQLYSRNESVRRAISHRAFAICVNTLERMGCHTQQMYHVASSYLRANLNAMHDIKDVSMVYCVAARVWAAISAMGDNYDRVTPGHTTLSPRSTLCKDAMTMVDSTGGHVESAKTTDAVVLQDAVVNEHQNDFMGEWCSIITLTAIVLDHLVQPCSFIRGEYVEGQSIATVAAHAAPYVDKGNSELLQRYSSFVAMAVEHVMQNTDVDHVSLIHLMKCAIGINRPQEAMLMIAAKSVHSVGLLGTPLEFSQHIANLKALQSNHFGDTVHELLDSIATANMLQFERRLAMPPVTTKPQPQRRRALRDLIKAATKKGAAAETMFVHNDLYNFYKGADAFRYCAKTIAAVGGFNGHKAAVDIAKRIVENIESLCASQTQHADLESVAAILTGLHRFRMKNERVLHRMASETMRHLQSKQHPSILSQILIAYAKLGSPLNRNIERGVVHSPGTKRITRSNKWRNSQGAFETLFVQALKAITADSCRQYMNAQATVNCLFALTLSGMGHDVPLFLYKLLALLRQFGTDCYKCVEVRKQLKIALLVLRRTCRKSKRAIYNQVKRVYKHAFKKELKDIAATRCTAVVTNRRNPTMSGLHREVWRHVATTCPDAVIRSEVTCTNRLYYTDLVVKTGNAKTYIEVDGPTHFFHATHQMMPSSKLKHAILKAQGKRIVHTPFYDWKPPLTLLKCHVRGNTRHRQAHNNDVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDR0</accession>
    <name>A0A061DDR0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0303890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768671.1">
        <property type="nucleotide sequence ID" value="XM_012913217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565026"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303890"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1685"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1577"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1747" mass="195949" checksum="2B3352E13131D86F" modified="2014-09-03" version="1">MAPQYKKLTDCPENLREAIDWLIQVRYGNGDNGEGFKKLSQALKKLIDEAIEKAYTTNFDVILNILNSVKSHTCCKDKVAKIEELKDPKKLAPNVFEDLKHDCESIRACSKTHFESSQKKSYEDIVSRLDQLGKLKESLAVFTNEEECKCLFDNLCSGLEKFLGFNPDSKGYDGTGIVYSDLDRLCDGVMAFLHGVLESVKDDESVRTYDSNQPNDINTLVNTLKNSVSDGHDALKNAVTEVGSWLGRYNEQVKEKAEKVSEALNAIRKEIAAKHVVKFNDTYTMTLQVIHHEFTKSINELDHKIAKLKHDRKGFAGIDSALQKSLYMPLEKIAGAFGVMKKSASNDFLCWQIEHIDEKFRELPRQLDKNILKNNEEFKKTLDAKFKEINGKVKSFQSTQLSDLKQAHKALSSALEKIQSDIGSKGKGFYGNVETAFNNLKSIVADVHKALEVKQGELARMVGQAELHFGTILRGVKENSAVTGQTDLSIEKHWKQLYTTVEALVESLTKKGQNNPDCLADIVEKVHNYAKTYDTEFSKTVTKWVEDIMRGNAVKGLLSTYVSNNHGRSLFEGSLRDNVIGIKEALTPIVQDKIIIALDDITVNTRPGSKKSVDENMAEIVSYLKTYAEQVSDKHTEIVSSIETALKGNPDFVLTQPETFSSDLQAAIKSALASVKSAAEGAADEIAKLRDTSHLSNLNKAITSVESIRTHINHEGLGNSGGNIDTALKGVKGAIDLLNPILQKVGGKLKICVDKLQSEVLTELNKIMKNGLTGKIAFRKYHIIEQLESLKNKIDHDIKSIITQLLELEKAIEHWIQETTTIIENSLKTANTELSKLNKQNREYIIHAFRQAQDAVQTLFADQKKADLLAIHDCIEEQVGTINGIIAADLQSGIKGLMKSMNDKHNILDHFKKTDHSKFTAACTITEEYLISLYGYVRSEIDAPPYITSLISLLPDHLNTLISDLATHHFDHRLYKNLDELLKYVDQMRPTSLAEPSNPLAEALKKGLMAFSGELGKAYVNRYSGQNWEREFRDNYGRIGLTILEIMKSSFTILSINCKSLGGKQINKSNDLGTLLLGQGFIVSDHGEQNGELRDDKNMIGESINNRITRPIKGVYDSPHLQYCESNARGKAYNFHLMDILKCLFRHCEKYNEVGHLSTYYASRLPCTVHDMLCWFTGLPYSGVYPTLLSDGFSDLLEKPKKQTIQSNDDLEIEFFDHKAQYLNAYPHRITYNNIDTVLGHLCSKSYDLITAIAGYGDAYTVYASDLCNNSMKLRYPSKPADCLDMLLDILRRLLLTLQYLRVQCNLDAKHGGWKQCEYGKTIKATNWPCKEHLSDKATCEAECRPNGQPKCQPTSPLMSYLNDCLPGSLPHQLGGIGCKYDCSTCTKSKPGTPCLTPLGFRGFSGCTKTGKDLYETISFFLGNGLVSSLLTLIPKPPSTLPEHVAFALSFVRGWHDSKTADAIGVKKELESKLKDLSIDLYKKPSDLTAAFSRAYGSRQNSHGLPHPPGRNADLSSLFMTKFCEYPGINVYCAPYMQSLCHNYYHYIAHKHSKLYLSWSLYLPWAFWECLNSLLNSFCNIICQDWGCRGCLRGDKCKKGSHGVVDEEKPSANCQCRSIVDCKGVAPTLYQFGFAFGEASTLNDKDAPKKCSAFCSQLKNVLKSKYFENLFRECDNFLWKIREPFSYLVLALWLLSLLYLIHIFIIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLAKLTYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS0</accession>
    <name>A0A061DDS0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768701.1">
        <property type="nucleotide sequence ID" value="XM_012913247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS0"/>
    <dbReference type="GeneID" id="24565056"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304190"/>
    <dbReference type="OrthoDB" id="366608at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28084" checksum="5BD01BBE362400B4" modified="2014-09-03" version="1">MVADSLTQFPHDLKEGIDWLIALKGTDPENNLKAMGAALYDFLADKPDGTMRMPALEEVKHITREFLEKPEIKYQPFVRGLISRLNEPVDQSTKKSFKGLSMVPKSAYETIIKSRGANPKAIAEKLGKVVDGCENFLKRIAVPDQYKCAYSSKATWAESCAKDPEACAVVLVGIAPMLYSGLRSLQIVSRDAFRQGPNSEASERMEEVLEAVGYKEAEYQSEKGRPIYKALSGVDLGIFTVLYDVARYWALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEI0</accession>
    <name>A0A061DEI0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769501.1">
        <property type="nucleotide sequence ID" value="XM_012914047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEI0"/>
    <dbReference type="STRING" id="5866.A0A061DEI0"/>
    <dbReference type="GeneID" id="24565856"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312180"/>
    <dbReference type="OMA" id="ERYTITS"/>
    <dbReference type="OrthoDB" id="366439at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600835" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1111" mass="116803" checksum="E55472D3907C03DB" modified="2014-09-03" version="1">MARRNLALCAAILALSSSLIGVGAAPATQAVVKELPRPDLMNRGKLILDFTAGNLDPRITMCNRLKGVTRYFVKPDVGATITAIQINDFRVDLPIAPKVEAVFCASPFNNTFTVVFNDETSDEFEVTSQGVEALTNKERYTITSVAKPPQRPAPEPSDASSSSSSSSSSSSLASSSSPASSNVSSSSSSSSSSNVSSSSSSSSSSISPASPSSPASSSSSTLSSSSTTADSSEAAKPESTPSAPAEPNPWRSAMSKRTESDSRHRITESPLHGSGSAPAMSPSLLRAMAKASPSMGAPQTPGFQQMRGRLRSMAERQITSRADKTPVLDLRAREAANKPTPAKQPSKMVFEDFQSIDDEFDTDVEDSSGASKGKDDGLLDVDGDEHRSASSQSTDASSSSPTAPSSDTSSSSDTSSSSSYSQSSTDTSSSSADVAKPTSDDTSSSSYTDTPSSSYTTTPSSDTSSSSSSYTPSSSYTTTPSSDTSSSSSSYTLPSSDTSASSYTPSSYDTTTPSSDTTTSSGTSSYTPSSYDTTTPSSDTTTSSGTSSYTPSSSYTSSYDSTKTSSDTPSSSSSSSNTQSTSDTSSSSSTPSSSYTQSSSDTSSSSSTLSSSDASSSSSSSSSHTTTPLSDVSTSSSSYVSSHDASTSPSKGPSSEDTLNSASHKLPPVPPRVPQTRYTGGSAEDANQNFKGFHAGGAMRAAVKPSIVPPPPAPPARKKKIMTASPASSGSKYNTHVATITTGDVESEHHEVQSNATAEENTPEASVKTDMTLVIGEPNENIRTQKNGDITCYRATNGHIIRTVEIQGKSRKVGVSYPVDTIVCALQRPGEYHLAVGSRDEGGKWTTTYLNKAGDMDIFTNVATKALFKDISLPTLFEDAYAEKSLRRDPMWFQNFTFNGKGNASLKQVEANGTLFVLETIDSGYLKSSKDITFVDGDIVTPEGMTMVNITTSKGEGQGYLTMTFRGRNVLHHKRYVESHDNANSYQRARYTANLDVCFDITTECFGLAPEARLAVLDAHSIECDAIMWGIEVKKYSGITFLSIPPRDLDTLLLIGNYEVLLSSKESHEVTILSSDIGLSADIRTNNSSGLLRTIITPNSKTRESYSVDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ46</accession>
    <name>A0A061CZ46_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribokinase like superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765904.1">
        <property type="nucleotide sequence ID" value="XM_012910450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ46"/>
    <dbReference type="STRING" id="5866.A0A061CZ46"/>
    <dbReference type="GeneID" id="24562259"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100470"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052700">
        <property type="entry name" value="Carb_kinase_PfkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320:SF3">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600456" evidence="4">
        <location>
            <begin position="21"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="5">
        <location>
            <begin position="89"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="368" mass="39728" checksum="43E4BB9BC06DFF2C" modified="2014-09-03" version="1">MNASYIFAAFVGIFASVAYGSKCQLGSGDEVLEKGPSRLLIVGNPIIDMTASVDYSVVEALNLIKGESKGLVTPDDFKRLGDSITVQARTAGGSSGNVARAYGYLGGKVAFLGRCGQDEFADQFSQSLAENGVEDLTIRIPEKFTTQLYSLVTPDAERTMYVLSGASRTLQSSDVDESLMDEFDYYVADAFVYFGDERVALTNKMVDAALSRGKGVITLFSNMTCIRRSGDALKELADKSTYISGNLEEYSTLYGIPNREDLFRMFEDRTSGSHPQHKAVIITMGGMGAMVIYQGKRYIVPPCKVDVVDTSGAGDFFAGSFLYGVLNGWNVRKAGKFAVAMVGDILSHMGISISEGTHTKINEIKGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ62</accession>
    <name>A0A061CZ62_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765914.1">
        <property type="nucleotide sequence ID" value="XM_012910460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ62"/>
    <dbReference type="GeneID" id="24562269"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100570"/>
    <dbReference type="OMA" id="WAPVEHE"/>
    <dbReference type="OrthoDB" id="361778at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="259" mass="29234" checksum="F49894F1EABF87C1" modified="2014-09-03" version="1">MVVAGDRKRRSENRSSVGSRGSVRRNPTERSQPVPSQSTVPANHTYRHDAPRRYHPRQPPRLRRGANKYESEDFKQQRMQQMEAANKHKYDMISKRQERIKKLADLTTELNSLVGKLSLLPKDAPEREGVSQQIQDVKFAMRRLQMERETVPNKIDNRQTKLLFKELPECAKGPGKLAEWIAGNAVILLPKQIAMLATAAQGALIQYRNHGAAETVMRSCKLHGIEAQWAPVEHEEGDGKGSEAPAKAENAADVDYNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZT3</accession>
    <name>A0A061CZT3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0102520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766109.1">
        <property type="nucleotide sequence ID" value="XM_012910655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZT3"/>
    <dbReference type="STRING" id="5866.A0A061CZT3"/>
    <dbReference type="GeneID" id="24562464"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102520"/>
    <dbReference type="OMA" id="LMIANIC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="10"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="422"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR93923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="613" mass="69558" checksum="B0F7F07596E7EC52" modified="2014-09-03" version="1">MAKAPTERSRIDVIVRKRPLSDLEKARGDTDVVLCNNTTAIIEELKLRIDGSTYIDRYEFRVDRFYDEHADNQLIYEEYVKPLVEFAFKEQKTCSCFTYGQTGSGKTFTMIGSRKLKNPNMPYMRKYLSGIYEYAANDIYRMLCEPEYDGRLEVMISFYEIYCGKLYDLLQDRYVIIWRIDMKMVEALDNGKREVIIKDLTLRRVTCKEDLIGHMLGGLTLRKIGQNSQNDQSSRSHALLRIELREIETMKNCGRIAFIDLAGSERGADCINQPKQTQMDGAGINRSLLALKECIRAMDLDKTHIPFRDSELTKVLRDIFVGGSRNLMIANICPSNVSCEQTLNTLRYASRVKNFRQPQTTGSNGAAETEHESSNVYRKHLSIPTYESSRLRSDASEYASGPSLAVSPRLKNMGLIGSKLMSTSQKLNKSRTLAPPMSSRSAVSRKISDITSPRETIRSAREANAQPYSRSRGSNLPDPFSSVLQSMKSQQRTTPSVETMLEDITLDPLNQNLYENICDSLELNASNSTSSVDADTKMKIEKSIDALQKAERIYNHIALQMMTVNGDPEIPNYAEFIKSKIKMQVKPLLFLKQAVEEHNNLMRVNSSIPGMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D042</accession>
    <name>A0A061D042_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766392.1">
        <property type="nucleotide sequence ID" value="XM_012910938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D042"/>
    <dbReference type="GeneID" id="24562747"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105150"/>
    <dbReference type="OMA" id="NVMPVEY"/>
    <dbReference type="OrthoDB" id="360584at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056322">
        <property type="entry name" value="Microp_apicomplexa_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23535">
        <property type="entry name" value="Microp_apicomplexa_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9240" checksum="728F700A128D3D03" modified="2014-09-03" version="1">MGLWGYGFTGDTTSSRAYRRYGGVYLCSMFLLPSVIWYCFGNPAVTGWFLKRVVPVTYPPESDPRIISRVYHGMEDADSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0P6</accession>
    <name>A0A061D0P6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766557.1">
        <property type="nucleotide sequence ID" value="XM_012911103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0P6"/>
    <dbReference type="GeneID" id="24562912"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106800"/>
    <dbReference type="OMA" id="IANEDFC"/>
    <dbReference type="OrthoDB" id="366025at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="483" mass="53481" checksum="48727748F40E52D7" modified="2014-09-03" version="1">MSSAVFEPTDLFSLDVEGEGFVPETEEEFTDCSINIKPSQAQLKPSFENTAGFEVSSATYVRPLRALNRPLTSEETKLCRQTILHMRRCIYSMIANEDFCVSCDVAGTNKGDMSQLSDISDTSSDSPMSEDSNVRQPSPSATTVNHSIEGSRKASRLDSGAKLAKTSHRTDRGREEASSAEQNPKLTRRDKPTGKRGSSQAGDHCSTDVVAGTEDGGSAAGSAKGPYQAAPTLRLTGMKLKRATAEDATSDRDATGADTSVDATADDAIKLTVSTSKLSNAVTDIEHTQMSSSVPFPRFSRSSRGNMPGGLSRNGRRYFFASDGEKLGPLPNCHMTFLAHLYRRKRSVCFFCGFVTCPRTSSPANNCPSMRCSRCSFKHKWGRNQCKDKGDMVKFYHRTSDWRQRRENPWSRMPKHIRAAAKCFYCGKPGEANFRCRGISCPKGADTLEVRCLELLGKKNLDRMVRQMPLMFTHLRDRHFEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D145</accession>
    <name>A0A061D145_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766727.1">
        <property type="nucleotide sequence ID" value="XM_012911273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D145"/>
    <dbReference type="GeneID" id="24563082"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108390"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="249" mass="27668" checksum="338D1E2B17A1238A" modified="2014-09-03" version="1">MAAELADGKTAENTCFGCNNRWSVSAEYFCCIPGCPGCKKIKCSTKNRCHCNVCDCGCQNDDAVREGKKRCYESTSNGCAKCKEICNTEKAGKRCICFLCNCGCNGVNCGCCTWCDFNDCSGVCNREDKHSVKCKENKQSGSKDYESGKYYCDEHLGGDCLGKNCNTIYYTTGTCRAKCQYCGTLCGQHVFFLQCTIGGPVIGIILVNIVVWLMWRDKALKAVDKMRRSFANRPGLFKTRWMVRGSMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D187</accession>
    <name>A0A061D187_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0108740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766762.1">
        <property type="nucleotide sequence ID" value="XM_012911308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D187"/>
    <dbReference type="STRING" id="5866.A0A061D187"/>
    <dbReference type="GeneID" id="24563117"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108740"/>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="53"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="234"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="395" mass="44967" checksum="47302024D39CFC91" modified="2014-09-03" version="1">MGASGGEDRTTYETSEECEVVESFEGLGLREEILKGIFAYGFDRPSAVQQRAIKPILNGRDVIIQSQSGTGKTCVFCLGALQTVNAASKQTQVLLLSPTRELAEQSQKVCLALGDYCNIEVHCCIGGKRVSDDIKALESGVHIVSGTPGRVNHMIAERHLNTRNIKQLILDEADEMLNRGFKDQVYSIYRYLPPTLQVVLVSATLPQEVVEITHKFMNNPFRVLVKRDELTLEGIKQFFVSVEKEQWKFDTLCDLYESLIITQAVVFCNTREKVDWLAKRMQDSNFTVCKMHGEMSQKERNDIMQQFRRGESRVLISTDIWGRGLDVQQVSLVVNYDLPNSRENYIHRIGRSGRYGRKGVAINFVKDDDIRILRDIEQYYSTQIDEMPMHIAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1F0</accession>
    <name>A0A061D1F0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766128.1">
        <property type="nucleotide sequence ID" value="XM_012910674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1F0"/>
    <dbReference type="GeneID" id="24562483"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102695"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102695"/>
    <dbReference type="OMA" id="RYHSIKT"/>
    <dbReference type="OrthoDB" id="419606at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="162" mass="17929" checksum="5E61166CE00A9890" modified="2014-09-03" version="1">MASKNSPPVLVPSDVTICEGLYATGSRQLSFSERLGLLLTPNPIRFTFTKNGRTELQAVLTKSYGDNDDTITQILRARQESIIYNFAGTVGLSLLSLYSLRYHSIKTKVLVVPFAAYGGSLIGRAFGDAYVGRWSEYGRDRALGDLPSMRYLTESEIKSYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1F2</accession>
    <name>A0A061D1F2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0107660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766654.1">
        <property type="nucleotide sequence ID" value="XM_012911200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1F2"/>
    <dbReference type="GeneID" id="24563009"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107660"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595875" description="6-Cys domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="10">
        <location>
            <begin position="836"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="966" mass="108955" checksum="AA14DA3C33D3E35B" modified="2014-09-03" version="1">MAKFSITMSVWAISGLVVQFVSLVDAAPCHFHIPHDMLRRAALITCHEDLDIIDSGTAICPREANDIEYVWHPQPQSSEETRLQTYVSENGKLLTVPISEVVRSETVKPFIRLETKRTISTLHFDLQRHELFVITQRRLIFICAPRDWVLNDTMQRHLHDLKGYDKVRILPWSSSTPMVEILKTMGNGVGVFYLHRGRSQSPLVGCGTRPSPLFDPDMEVSVDRVTGTPSCVVDPLSVSRIGFLCEGQIEPHDCMISLLDGDGGVVVPPHPRFYWKFVHHRPWVVAQYFDKLAVRPFYGECRCIDPQTSRLKARIEMRSKTDHVCDIASMIFRNRLRPIRGPWCSAVLHPGSTLTIKIPTQPVNSVSIDVDSDGDISEDVSNVPFSQLPSAYEYESEFLPKDLTTLRQLIKPYDFESYNERFYKEVLAGDAIELDLSQMSRGVIKLIYNPNKPLALKYGTNSFCYYWKLASTNPNNLDKIFAPVVVSFACNHRYILRGCDRMQRGVFDPETSRKYCSIKLMGSGIGNIYECSLQVTKDAWKAGIYCGPDEELLPNNCDSVMYDLQSNSVVPYPGFIRKTSAYSIRGFQDLQFLFRSDVPISYACMCVDKRGYESSRLVLGSNNEVTHAYEVNRRTRSDTLLPYLSLPWQKVVLLTEESNSSMMVDLHKPRMHSVELDVGTTLLLRCKLDYDVANPVNNEINLVTWLPTQVDEFHYSIHHTFHGSKLIRTSREAVMVSAKGGLQAVFRKYLEGAVYQTLKITSRRNAVIISKDPTNTKRVPLAFVCGKAPDQSSLSSVNGEGSTSGASGDAHLQNTKLSDEHNWHVVVVNVETTDPYMQGCGVTYASDELFKPETPKLYDADGREIGCKIDLQAAKEAAFYCPVPYVLDPPNCFNNVFVDGIVKKVNNLSKSLEASRTNHFVTLAFKSKLVGRGETLRQTPPLECRCVTLKGVTLSTIQVENYYAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1F3</accession>
    <name>A0A061D1F3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766817.1">
        <property type="nucleotide sequence ID" value="XM_012911363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1F3"/>
    <dbReference type="STRING" id="5866.A0A061D1F3"/>
    <dbReference type="GeneID" id="24563172"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109290"/>
    <dbReference type="OrthoDB" id="10683824at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="18719" checksum="8CB95D53833F396E" modified="2014-09-03" version="1">MTAAKLTEACLYSATVIYKIRHNNDFKAFSTFDFESVYSKFRYSTDPACLLCQLRDYVYACHHQLEFLKAQCNRDKSLGGWQNCKYGSDIKTPSPLQAFLTDGWDCDFKTHPFDPCNLCLKNRVRIRFKKRDLPEKLQLGNVISTILTPSCGGEQHDAMRVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1G2</accession>
    <name>A0A061D1G2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUCLEOLAR RNA-ASSOCIATED PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0107760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766664.1">
        <property type="nucleotide sequence ID" value="XM_012911210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1G2"/>
    <dbReference type="STRING" id="5866.A0A061D1G2"/>
    <dbReference type="GeneID" id="24563019"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107760"/>
    <dbReference type="OMA" id="DERAHIP"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="3">
        <location>
            <begin position="141"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="4">
        <location>
            <begin position="588"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="5">
        <location>
            <begin position="750"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="6">
        <location>
            <begin position="918"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1190" mass="134114" checksum="E183E4B2813756F4" modified="2014-09-03" version="1">MPEKKRPRKRKASGGHRNPLIGDRHLPLEQALDSGVIYGTSLPISRLNRLINRECVDFDADGSSVGQSPLATLLRNFRSFVTTVPTVLLTREFIDKPAYGRCFRTEFNACWSNFEYGVPESVDVVGRGALGFLNRRNPTLDVSIMLPQAIFNPKDYINYRYLNKRNAWLCRLYEDVHVALEAGESSPLLEGLENCHLVAELHFRRPKVYIDFLLAVANATYCLRVSAHVDEATFKHAPMAPTRNNVRSTTTLLKPSGVPGTPAESDMRPTPTYNAAILEDLLKNRVNAKLRAAFDSHAKMRGALTLLTVWTHTQGLTATNLGCTSDRLHIVASMWCSKGLEAAEKRRVRRKVKDESDDAASVDDSENVEVSHDPTSSSPISGGSTDATETHGLGDEADKSSIQSGLPFDNGLTGCVFALILCHVVSANRFPTEIEAFPLFLAALKFLASMDFKQKYYIIGRDKAFNSHAADDDDSTTAVSTSDDASNEDGAKLLEAQQKVINAISIPELYLDDSVSFNVLHKVVVTFDEVVARAKATLTVARDLSSPFLYCQLFDISHDTRCYSDVRLIMNTCPLLSGFDIWELGESEYMAARIRSILEYGLKDRLAHLYFRMSESNALMVMIGFDESVQRSTDVGPLTNSPESVYFRHFWKRLTETRSFADGSICECILWNQILPDIDVDPCASSSLERLAGRNLNVQILSTILQLHLDQFKPVILDCDTSFAFDKPNTKDGDRRHLMYVELPIVVSDNRLATEHRTKLMNAYNELNGLLRSLENVPLKVSNVFVCSPEFGYADVGPSKLRHRLLVELETSTKWPKDPAAILSVKIALGIAMLKELFKNHDIKSRMSENGDMELQFQGIRFCIKILCQRETQPLIESIRNFNPDENKLPTDSSLEMVREYFRSIQIERCKVGALKSPSFSASVRLSKAFTASCIVPNGEFLCETLNWFIFCSQDFLLSPPLSGYTGFMRFLYMVAHYDWEHRPLVIYNEEPRYEMLDSKKPSWAPYFWLCTPEDPYCLVPNMPSTMLSKRFVGQCQRFIAKLDEHFMKPINLAAYFAAERRAYNMTLELENVYRKLKYSAGGESFKLSQEEAHFLLDTFVTSLKKSFSGILELAYNHLELQGTHTPAGNIMIYVKINPMACIPTGSPKGSWPHHMIICDGRTIFVPNMPAIWTHIHAMGDGLLREIRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1N3</accession>
    <name>A0A061D1N3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0108560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766744.1">
        <property type="nucleotide sequence ID" value="XM_012911290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1N3"/>
    <dbReference type="STRING" id="5866.A0A061D1N3"/>
    <dbReference type="GeneID" id="24563099"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108560"/>
    <dbReference type="OMA" id="TMSKMKP"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="261" mass="28402" checksum="AC17C07D0B37B8E5" modified="2014-09-03" version="1">MALMRALGRVLGCLFRWRSKRSEQIAEFKECCQLVAIKRAGGQLDDDNFWVLYGFFKQTVVGDFNPKDLEDSTEADRRKWASWQKCKGMSKADAMAAYIALVRNLYGYPTNTDSMHPTMSNAVSRPKVQPDNASDADESEGLFALVADNHVGMVDLLLKANPHLVNIRSPEGLTALHIAADRGHIEVIQCLLKHGADIDAMDDNYDTPLLVAAAAGNRQAVSVLLRNGAVEYRRKSDSAEAQHTVNVPASSCGGGAAAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1P0</accession>
    <name>A0A061D1P0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766897.1">
        <property type="nucleotide sequence ID" value="XM_012911443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1P0"/>
    <dbReference type="GeneID" id="24563252"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110090"/>
    <dbReference type="OMA" id="TRMNTEN"/>
    <dbReference type="OrthoDB" id="366383at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50549" checksum="08B0B55F99DE7C27" modified="2014-09-03" version="1">MKVACKAPHGALVRIFRRFCYSDAIITGRFACLSTLATPQGSRTKQTFGIQGSHLNCFRRFSTVQSHSGVTSEADIEPGNDIFASATAEGHGTAKANRGAVSTAEILATCAELAEAIVFDRNKHSARIRNLVSSLGPKTFTDALQELDCLNILDTKKRDAPKLTVENLVGSLSMLSEVCYVSAAAGIKVPANLLLGYAATLQQALLQLLTNSAEDTSKAPTSLQFNSIALSCTGEERNTLLEGISDSLGLILLSAAESGIGPDVLPLCNELSSENTLAGFIAQATGSCINSVAFVRAMRALESTGKVDGGNPELTEILPSLRQTLTALSNKEMTMTLRDLFYCKLWITCVTGHNTDFEGELDHMGRSFVDNVATIDHIVEATGSISDADTAMYAQLRRDKREVDLDYLTLEPFVFPLIGFSDKALYEADVPESYFDADARANKREWLKWRSAIAELNEWKIVEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1U1</accession>
    <name>A0A061D1U1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPL4 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0104050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766283.1">
        <property type="nucleotide sequence ID" value="XM_012910829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1U1"/>
    <dbReference type="STRING" id="5866.A0A061D1U1"/>
    <dbReference type="GeneID" id="24562638"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104050"/>
    <dbReference type="OMA" id="MYGYYKE"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore localisation protein Npl4 ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore localisation protein NPL4 C-terminal" evidence="2">
        <location>
            <begin position="219"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="492" mass="54652" checksum="DBFABD86FDEB38FE" modified="2014-09-03" version="1">MIIRVISGIGISRVTLQADATLGDLKNEIRNRIRVPDGTTLKFVIADSNSEVFLKFYVYTLHQISGSDDEALAKFGVGHGSCLRLISVSSNPSGSEDLSYIQPSQSSERQPVSEQTPSAPINVEPTSTKEDKPDGVSGPSFKSFDAYLRDNGYAVSELALQQSYKPVFLERGKMNKLPSGVTVKHQPYRHVDHLELMNAEDIQNFANYWMSDLEMAEQRAGWLYGYYVEDAHYPLGIRAVCEGIYEPPQKSTLCDVEFLPDEFLPVVDTIAGRFGLERIGHIITHLPRDNYLSPQEVIDSARVQLERAHSTHYTGYPVSTHVTCTLHPDSEGKPALNVYMVSDTAMALLRDGIIRSVQSDPMFVTIREPSQSNEVLPQIIESGKEVTKFDPSWFVIRVNDSAPIKPNSMFKYADFPRENRGGRSVTTDAVKSFLSSRFANGLTASDPEIFSDFHLLLYLGKILDIDTTLAICDAVMGSAPLDPIMVDLLMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1W4</accession>
    <name>A0A061D1W4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apicomplexan specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766303.1">
        <property type="nucleotide sequence ID" value="XM_012910849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1W4"/>
    <dbReference type="GeneID" id="24562658"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104260"/>
    <dbReference type="OMA" id="QVGLNCT"/>
    <dbReference type="OrthoDB" id="361877at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24092" checksum="D96F6F063E357582" modified="2014-09-03" version="1">MRYGRPCGRSNAAVASRLDACLKSRSDIIKLDGLQNTSLLSMREELGRRFRKPASYFDARREEVNELILETLTEMYGTDQLQELIKSEGLDAVDNENKVESLEEEPPTTKRAAPTEATEVLPSIISEPGDEVEKTAKRAKQSQANIMTRREFMKNAPKLKVQIDDSVFNVAPRTFSTDSCGWYLSDKVKLDICGQTIVCQVGLNCTVVGSKQWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2H2</accession>
    <name>A0A061D2H2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicle-associated membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0201280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767157.1">
        <property type="nucleotide sequence ID" value="XM_012911703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2H2"/>
    <dbReference type="STRING" id="5866.A0A061D2H2"/>
    <dbReference type="GeneID" id="24563512"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201280"/>
    <dbReference type="OMA" id="VTKYMGY"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="7">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="225" mass="25204" checksum="B02085C50CCDFD06" modified="2014-09-03" version="1">MVQLLRITPEEVIEFPLVLYTPLNANLKLENISEQNVAFKIKTTAPKGYLVRPSTGVIKAGEQQSVQIILQPLSEAPKAVNDRFLVQSVTYVSEEPVPKDLWTTVEKSQVGEHRLSVALVKDPGLNIQSGNSPHGIPPRIAARLFTPQSANVDLPELRQKYDELVQYCLSVEKLKAQIIKENEQLRQRLSMGPADSVGTRLYVELWYIPVIILLMALVAKFMGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2I6</accession>
    <name>A0A061D2I6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766979.1">
        <property type="nucleotide sequence ID" value="XM_012911525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2I6"/>
    <dbReference type="GeneID" id="24563334"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110900"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="94" mass="10380" checksum="A72DF9D6B98811A5" modified="2014-09-03" version="1">MGWQLQRLRGLGGRGEDELYSAVPQRGSSSSRAASPPRADPHTGPPSTSPSNPAPYIIVPVALIIVVICVMIYFRIRPFHRVRNDCVDDKSHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2X8</accession>
    <name>A0A061D2X8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766633.1">
        <property type="nucleotide sequence ID" value="XM_012911179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2X8"/>
    <dbReference type="STRING" id="5866.A0A061D2X8"/>
    <dbReference type="GeneID" id="24562988"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107450"/>
    <dbReference type="OrthoDB" id="366399at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="156" mass="17602" checksum="E8F4A104716E5F34" modified="2014-09-03" version="1">MGPRSRKVGGDAEIFSKNASQLAHLVRIVSRREKEDSRFWSQVTRRLVYIIDTISTKQLSYIANGLARARVADPETWDSIVKRHYQLQHDLVLMANALAKVKSVENGVFQSIIQRIKVKFQLAGYSETKVVESLLDRLDLEGSQMSVVSMAILLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Z6</accession>
    <name>A0A061D2Z6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766653.1">
        <property type="nucleotide sequence ID" value="XM_012911199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Z6"/>
    <dbReference type="GeneID" id="24563008"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107650"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="421" mass="46620" checksum="12A60424DA19013A" modified="2014-09-03" version="1">MVYNSLTEVPRNLKEGIDWLIALKGTDGAKNLKAMGAALYNFLSDKPVGLTEVPALENVKHISQQFLEQPELMDRPFVKNLVERFNKPTGESQQMHDPVSMGVKESDYKNIVEAWNITPENIARSLGKVVDGCEKFLEEVKIPENYTFAYSSGATWDSSCAKDPEACAVVLVGIAPMLYAGIRSLRDAGKDATAKETDPMEDKHLGSVLEALGYKEPAGRAALNTSDVLNLLRVVDKNVLNILYAFSGFWGFYGLDIPVDVDDEPFVDFEDLASMDFDDDPSVDFEDLASMDFDDEPFVDFEDLASMDFDDDPSVDFEGLASMDFDDEPSVDFDGLSSVDTDAESVKVDKLIKGGKKGLKKYSKKALKRALKKAQLKKLKNSGKKLPPKYAKKLAKKLAKKAAKKSAKKDKKKQVLLQLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D301</accession>
    <name>A0A061D301_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767332.1">
        <property type="nucleotide sequence ID" value="XM_012911878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D301"/>
    <dbReference type="GeneID" id="24563687"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203030"/>
    <dbReference type="OMA" id="LQWQAVW"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="373" mass="41151" checksum="BE4D6596A76C505B" modified="2014-09-03" version="1">MSYIPSQAAHSVVQRIIDDIKKNAVEIAGRHARAKLRSSYVERSPGARATAVTPRLQQTAARRQCPVPGRSTHVSAGDYFTRLVNSSPKPRVLRSAAHPVAIHLLKLAHSAAYRKYRKLVLLSSPKLIREYCERHGACSRLYTTSFDNPLLMEPQIRGNKVLTCSEKLLRKIASVHSYNNGLLAEVPYPPPSQHLGNATLVLCVGASARAAERDTAATLMRTAHALQWQAVWLLQHGEHDFLDPRAIRASQNCLDTMPYITGDAREAVNFAKENGLLMCVCADGGIAIGSENAQQILKRHRGMMLLVGKQPRELIESATKLDVMLSNPRGHVVASECAAPRQYALDGSTKSCILMYLVRKQLHFTAPRSPYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D368</accession>
    <name>A0A061D368_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767382.1">
        <property type="nucleotide sequence ID" value="XM_012911928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D368"/>
    <dbReference type="STRING" id="5866.A0A061D368"/>
    <dbReference type="GeneID" id="24563737"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203530"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="1">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="548" mass="61493" checksum="1D8A3DFFE4D287C0" modified="2014-09-03" version="1">MLRSFNSNGYKVYALSAGKFAPQFHVSSKGKKKSKADAEYEHRIDLIHDLEFPQACNTVDISPDLQYIVATGVYPPQIGVYDTTELSLKHRRGIDNEVIKTCFLEADYTKLAFLCTDRVIEFHDRGGRYHSLRIPKAGRDMIYVSDNASLFAVASCNEVYRLNLEHGAFEEPFKSVCSYLNCVAENPILPLISTGGEGGVLESWDLRCNKSVSRLHCTSEDDGGDESVTRCAYSANGLKVAVGTSSGCLQLYDIRNTKPLWEKRHVNEAAVNNIEWVNSLNHASTGVGQDALIAWSDHKSVRVQNTHDGEFVASIEGLVTDKANNTSKINSFRFYPDTGICFVVGDHTRVGTYFIPTIGAAPKWCSFLENITEEMEMPSAADTGVAPGATKQAYEDFVFVTRQQLEEINATELIGTNMVKDYMHGYFIDSDVYRKLKSASSDFDYEAYRKKKIQEKIDAKRQMRLPLRQKKTQVVNEELAEHLRQTAEAVGKKGLSKKEKEQALSAKAALQDDRFARIFTDENFAIDHVEAAEVSAKRRYLTTQNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3B7</accession>
    <name>A0A061D3B7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767417.1">
        <property type="nucleotide sequence ID" value="XM_012911963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3B7"/>
    <dbReference type="STRING" id="5866.A0A061D3B7"/>
    <dbReference type="GeneID" id="24563772"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203890"/>
    <dbReference type="OMA" id="REGECNE"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47817">
        <property type="entry name" value="OS04G0686300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47817:SF2">
        <property type="entry name" value="OS04G0686300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="118" mass="12515" checksum="A2C4B65AD388AD59" modified="2014-09-03" version="1">MGARKTVAPPPDSDQSPSPLAAGQNGSLLLKVRVKPGAKFTQLVGNFEDPLGVQVAAPPREGECNEALVEFIGDILKLKKRDVSLTSGHKSRDKVLSITGIAMSAAEDLIQRQLQLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3I0</accession>
    <name>A0A061D3I0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0203000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767329.1">
        <property type="nucleotide sequence ID" value="XM_012911875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3I0"/>
    <dbReference type="GeneID" id="24563684"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203000"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="131" mass="14479" checksum="4E4D03B0F83E554B" modified="2014-09-03" version="1">MQGCGVTYKLDELFKPETPKLYDSYGQRKSGCKIDIQAAGEAAFYCTAPYVLDPPNCFEEVLMGGIIMNVKDISKSLIASASNHFVILRFDSELIGSGETLRQTPPLECRCVTIKGIVLSTMQIENYNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3J5</accession>
    <name>A0A061D3J5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0109450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766833.1">
        <property type="nucleotide sequence ID" value="XM_012911379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3J5"/>
    <dbReference type="STRING" id="5866.A0A061D3J5"/>
    <dbReference type="GeneID" id="24563188"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109450"/>
    <dbReference type="OMA" id="TSDCKLA"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="475"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="519" mass="57148" checksum="1BE2F3A441836708" modified="2014-09-03" version="1">MSTTATADEGVPLLPGTEKAPRRRMTRWGKIDDGKNMVIHNTTNSFLHELKMLSNKAANVTEEDESQSLWGPEDDRPFLPPPFVDLPPGMTPSQMDQFLREQRHDDLVKKIASGELELGDADIRPPSPPPVYDRNGSRVNTREVRAKNAMNEEYNRLVEYLLKHLPGFVASADYKPLKKVRKIIIPLDKYPEYNFMGLVIGPRGCNHKRLEAESGAQISLRGRGTIKEGKQRDHQTDEDAAMPMHVHISADKEECVEKAVALIGPLLDPFHPKHEEFKRRGLEQLALVNGVALGISDASRCSVCGGVGHRAYECPDAPNLHTVKHADVRCAICGFMGHLTSDCKLAGSTGTTAATQEAVKLDQEYNRMMTELTGGGAAATGEQDPQSAEQLQQYQMAFYQQQYQHYQQYQQQMYQPQQYYYSAQYYPQYYQQGAQAVATGESGVAQPAAYDYSHYATAAAAAQVTVAEQPAVVPAETAAPMPPQTAAPPEPELPPEPFAAAPDEPAPPLPEDEGAPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D451</accession>
    <name>A0A061D451_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0205060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767534.1">
        <property type="nucleotide sequence ID" value="XM_012912080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D451"/>
    <dbReference type="STRING" id="5866.A0A061D451"/>
    <dbReference type="GeneID" id="24563889"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205060"/>
    <dbReference type="OMA" id="NMLEICE"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="763" mass="87353" checksum="EEB60C7189D3044D" modified="2014-09-03" version="1">MTKFWLSLADFVCMEIQGFPFTYKDYTTVSEDEGIDTTVAADKTVNRPSPNTDTFEETIVDPLHSIPQNSLRQMLKLPKYVEQIMWYSFSVCVDALLFELTLMPVQAVGTIMYVSQRWMMWLTTFYKKDLTDLSVSESGDTAPLDKKFMGSCDCTGGYGDPTASCRYRPKRWNTKGGFGDLCRMQCADITDSIVNDNMETDILRCVDGTEKQASDQKSQTEADVLPENNYLRNAYEILYGCFKNCKRGASSLFKVKKVTTMDDTNLLSNKDVLLINPNEACGAARFMALVMAVIILSRIDTSRVYHNIRGQPFFKLYVIFNMLEICERLCRSFGRDCTDNLMRAAIKLYKTSTNFDSRITAILNVEQLQKKTDDLKQNTNGQSFASAVITNASTRFGSQMGISYNDETEQPTHNSVVSCELRTHESKMEAHGTVPPSSPIHFGRVAQTRELIEPVACKTTGVISSPHPDAKLTKNWHHYPNELLEPSMDTLPDSVTHDASKDRQQWRSLLMEFSMCYLLVIVYIMFHTFMHLVRMLSLNIAINSSDSAMFLLMVTNNFAEIKSTVFKKYNEVSLFTIVATDSVERFHLCFDAMMVFFKMSTVRSPVNSYFTVSRWLTKMFVLEVLIDYFKHGFLLKFNRINGQIFKRYTEVLMGDVVLSRCWRIKQQLVNFNFRVTCKGTYSFSHIPSRRLGFMPSPIVTLIVCNIPYIRNMLTFWRFLGAVFIWLTLFFAKIVSSILLVAHGIRKRKNLLRLKSPMDKIGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D454</accession>
    <name>A0A061D454_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767003.1">
        <property type="nucleotide sequence ID" value="XM_012911549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D454"/>
    <dbReference type="STRING" id="5866.A0A061D454"/>
    <dbReference type="GeneID" id="24563358"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111150"/>
    <dbReference type="OMA" id="QTPKQGQ"/>
    <dbReference type="OrthoDB" id="367255at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1010" mass="107464" checksum="F0487466E97D246A" modified="2014-09-03" version="1">MEEATTTNSDRPRPATTTAPLSLGEKLLGRAMKKGGISVSVHGVAVSITNHTRTTGSAWKSDPRINVAKDISRWVHDSVPSGISTTHYRHSSCLCSPIDDGANRQEQKPRTESKHLKDPFKETTEERAKQPSGAWRLGKNTLVDDILGDKFIMPGMQGTYPLGYRNFIGKGTKKTPPPPPENPPPKPAAEEYAMSWSVSDNNAQKQDAQLSRQSSAWEETVTRNLLLENLTDDRAQGQSCYDASLNRVLAGYSHMQLQMDSFPENVANSAGLIASHLDAQKRKGDDVEQIGQSLSQLDESFNRHIAAEQADMMLSSRPATSLQQDFSANLAAAEQKLRSATPKAYGVTNNQERGFRSRQPSATSRPTAAGTPARMAPDPTVSAPPGMLEEPTVDVPPGVLNDPSLDAMSHLNIKSAEESRAGAKQKSLERAQRKAKSRSADRSPSAVNAKPLEGEQALAKSDTPKRGRQRVKPRSADRSPLGDNSKPLEDEQMMVSSASFKGVLQGLKPRSADRSPQAGQAKPFDDLRLAKAEPSEKSQPEVKGKSSEKTAQKAGRNTPEKATSAAKSRSTGGALPRVKAQPIVAAPPGLTIGAPEDVLQQAKAKLDQGLPPNAKQLSRERSPLSVKSKTPVDPLFAAQPQLAVPIPLAVISKSPEQEPTGGKRKAAEKAKRKGVAGSPNEESNLSKAKTPEGTPAGLKAKPNKAGQQKAGAKSVGKAAPGPVNEQSLDSAPDVNTVALKDLQPSAKAKSADRAPKKVKQKSADKSLTPAQSGSLEDAQIIVKSDTPKATAQDVKPKSTDKSPSAVQSKPGEDEQAVVKNDAPKKAPRKAKQRSEEKSTSAVDSKPIPGDLRPVKAEPSEKSQPEVKGKSSEKTAQKAGRNTPETTKAKSGASKRKQKASGADAPEDNTAPANVEVQDAKTIALNTVSAAPAPKEEVDRSKAQSEQIVKESNSHSAEEAHPTNGNGGNKVAAQNEEAEAPATTTRNTKRKSRHRKPASKTQPAGSEQIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D457</accession>
    <name>A0A061D457_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0111200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767008.1">
        <property type="nucleotide sequence ID" value="XM_012911554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D457"/>
    <dbReference type="GeneID" id="24563363"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111200"/>
    <dbReference type="OMA" id="PANIVQM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595949" evidence="3">
        <location>
            <begin position="22"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="357" mass="41064" checksum="5CE9C7D1D57F9791" modified="2014-09-03" version="1">MQLFAAALAITAAIKWQPAESLEPLLESNEPPYTLINFALEEDPRVDQRYSEKQRLVRLTCLNKHVQNSRRTRLDTQFSRRREWLDTQFEHLRRKQRQNKEGKWNQVSHTQRIMHWARCLLAAIRPSGLAVRLPRTGIADDTRNVNKALKSIRKELGVSQMRETKPKPPKPSDDGDSASIGNKLDVARLNLKNKLHRSIWLAMKRRDKPQFTQLEKQIRATDVELDGVSYTLLVHATLLFHGPGDEAMALIQEMRERGVHPSLIRFNARIVAAHAEMDGLGARPLPANIVQMARASWLTAVFITRRYPTQESILRMEAEIEEREQRYLESDLAVEEARQRELVNSPNGKLTKGSPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4A0</accession>
    <name>A0A061D4A0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767058.1">
        <property type="nucleotide sequence ID" value="XM_012911604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4A0"/>
    <dbReference type="GeneID" id="24563413"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200290"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="93" mass="10549" checksum="B0D202646DBC66CB" modified="2014-09-03" version="1">MNWDARVGAAVNWRLTSSLTQWVWKQHQPRSKTLYKQQIVNAVNKLASDFRCSDVPRVPILVSEQRSDDATGRMLKMLPQLNGAQILALSNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4I1</accession>
    <name>A0A061D4I1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767143.1">
        <property type="nucleotide sequence ID" value="XM_012911689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4I1"/>
    <dbReference type="GeneID" id="24563498"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201140"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="299" mass="32903" checksum="6D27F47C382AC9E9" modified="2014-09-03" version="1">MVYTSLTEAPHNVKEGIDWLMALKGTSGESTLKAMVGAIHHLFSDHSAGSNPLPSLDKIKSISKEFLEKPELRDNIIVKQLLSRFYTPASAANTGSKRLLTRYSEEYARVVGVKGAKPEYIEECLSNVMDGFGKLLNDIKNPDKYKSAYSAEATWEASCAKDPETCAVVLVGIAPMLYAGLISLWGTTESKTGEFHRYAGSRSFGEVLRALGYVQPQCRSDINGSEIFKNFKGLDADLFHKTYDIAGFDTFYGSDIVQKLPVKQPVVEEAVVAEKSVEPVKAAKSRKPGILRKLRKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4V5</accession>
    <name>A0A061D4V5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767263.1">
        <property type="nucleotide sequence ID" value="XM_012911809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4V5"/>
    <dbReference type="GeneID" id="24563618"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202340"/>
    <dbReference type="OrthoDB" id="365897at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1157" mass="123847" checksum="2A373468AEC88A3E" modified="2014-09-03" version="1">MKAGYVPAWLPAGFKADEDRPRCRLSPLAHEWLRRIEDPVCKCRCCALTVEVAGANADGAVPRSEGATTASQSTKPRMHDWVDVCGIGTTVSPRHSGGDAKPADAVPPISPSMVNRYGVSGQVAAATVADGSGASCPSPPDAVGLLPGEADASYHCALRWLGRTLAHLDALERLSFGQEFRRRQLHLLLSMDADQGCGGAKAVGDASGGNGGRDPHAAVATLLRQWIAFDDNFRRVYADVCRAYNRLVRMEVQLNLLRTNSLLMLEEDSCARSTPRQGMVTHSDFAVDSERYGKLVSIWSSKLVALRDRNLSEFRHYVVSAVADLSTLPVPRALVFVEECEAERSLVMSSGEEPGEQQQRTSKDSAPLRAGATYVGETDAVSGSQGATNRGSPSGDQAELSPFGSFRTTSVDGVLECTLDVADEDAECYEDECPADYTELFAEAVDVVTDYCQSRGISEESSLDYVSRVSDLSNRLLPRVVRASASTPIHSDDYLDATVHCLRDPPAVGETQGASASIDSSAGAAVRLVKRDAGRDRYHQTSTARVTSDVSSVNSVPSRSARSSFGDGLPAWASKNRYVAMLLRTNLTVVDALRCLPTAPGGRRKLVCFSNGSLRDLFLNQPGATESVDLGSLLASHADGTFMGDPGLREDVKPTAQLRSGPEAVLRALLTEDLASDEIDKIIHTWFPTLSYSPSRSVPECAAVFNWRSIRDVLAPADDEEPDKRGDADYLHSAVWRHRLSAFNALTGLHLSRLLADRALVEPRVRYDSGGYADSWDFLPLRSTCDFRNHIPIKYTMRSSSGHGGSSYGWVQSLFGGDGVAAAGPDRGPHPKVSPHSGAPADVLPIACASTPVNAVVIPIHCGPIELSDAYRTMGEICDCLTDYVFPPLYEQHRFACVDVKYGARVRSAKRHGKCDASPRGDGGDVDRVGACCELGATGCVDMGGNNCQDARCRVCRVGCRQAGPAPLSKKEPADKSKASHGPCCGGSAEIDTTRLGNVFVSRHSNLCLGSQWSSHLDRGSVSLVFYIVCCEGADAASHPLLDPGSHESILRQSERMRPVLSGLDRILSLCARWKVATLSLPAALSCCFRADGGSGGADSGASEAYMRCLATATHLTAGMCRRAYPVAVNLVFPEALRASGVEKAASTIFSSRMGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4W9</accession>
    <name>A0A061D4W9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767927.1">
        <property type="nucleotide sequence ID" value="XM_012912473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4W9"/>
    <dbReference type="GeneID" id="24564282"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208950"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="93" mass="10584" checksum="967E9BC7BDE91984" modified="2014-09-03" version="1">MLSRGTENVFDCVLPTEVQHVIVTTQRVFPLTVTATIRKLELTKTYKIDYSNFITRKGVNVEQPAFYTAGSISTMNTKTILPPFKNNITRINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Y7</accession>
    <name>A0A061D4Y7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766210.1">
        <property type="nucleotide sequence ID" value="XM_012910756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Y7"/>
    <dbReference type="STRING" id="5866.A0A061D4Y7"/>
    <dbReference type="GeneID" id="24562565"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103395"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103395"/>
    <dbReference type="OMA" id="KNYICTS"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="198"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="290" mass="33179" checksum="69593CE1F54FBA1B" modified="2014-09-03" version="1">MCTRSFFLGLRQLALRPGIPSLYYPLRTLRQPLPPLRFSSTRVPHGHIHQHPSCINLANRPPGRFFHRDAPSKDVESQSGSKNTNSEPASESDTPSHCAPDVKPNFKEKLLRRRKAFRRALLRLKSRFALFKIFVRHHALQRSKNRLSVVKRYLLEKKLKFGAIPRNALHRKRMRELKEKMVKKSTALQLGKLAVFSMKKYGKLGAAIYFGVYVATLLLMNVLTFGGVLSSSDLRKILERINVTHFQVPDMESNIAKFTVAYIATKVVEPIRLLVSILLVMAVNFAKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D500</accession>
    <name>A0A061D500_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0103530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766225.1">
        <property type="nucleotide sequence ID" value="XM_012910771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D500"/>
    <dbReference type="GeneID" id="24562580"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103530"/>
    <dbReference type="OMA" id="LNFACVY"/>
    <dbReference type="OrthoDB" id="361225at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600057" evidence="8">
        <location>
            <begin position="31"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="200"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="477"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="616" mass="68849" checksum="75EDA416ED8C2A63" modified="2014-09-03" version="1">MKVNTPRTAMMIAVSVALVATHTVVKRAAAEMWSVKDMFNNAVEKVTSYAINARTIQYVDDKDFGPKGEMMQTVELAPGQSIKYSCGKHGTAAKGTFALVPSDPRKHILAPKGDDPFEVALNRIQPSYNVYRSDRSLIVETFQRIGLDHLLIDYADNAVIMAKDNERFSMNLLCVFVPADVNLAPKYGWLQIKFKEVLPMAYGCGSAGFHLFKNAIPLPPNPSDESIMEASRRRIEAEPGMVIGIYCAPNDHIYPSDCFRKVKARDKKGETTNYFSDPDFKYRNLKGNIRLMKVKAGAMGFPAFTCYCKNAENQTTAALTVAMSRKETCDFTKLLEFYGMQHIIPRFLCYKRLGRGKSVRLVVDKSDGMIDQNRLVGGLTLHPEDVTNITYLSMKSQERMKKVRIDHLIGSAGLRITQRENKDNYIYDFDVTDDAIIVLKQPVANLTYVYDFYDRFQDTPKTFTTLVSLQIVPTDPYTHGCGVGYSGLFNNEGVVFENTHVKTGKTGYHTQVNCTVNGWSTSPVGFYCPKDHILEPSDCFTSIFLGSTDRTAKMADYAPLARVINAPNLRVIDFSAPNTSESKSTYSDAALQCRCKTKDGTIVATITVTLNKPQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D563</accession>
    <name>A0A061D563_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767894.1">
        <property type="nucleotide sequence ID" value="XM_012912440.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564249"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208620"/>
    <dbReference type="OMA" id="CRLYSYN"/>
    <dbReference type="OrthoDB" id="377790at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1678"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1685"/>
            <end position="1702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2241" mass="238633" checksum="B4DD4CF26776A240" modified="2014-09-03" version="1">MAVPVRVKQEPVSESFPTRLPDPAALMCSKLMSCPSLSLRHLLEGSDAERAEKTQLLTLQLSRCHQSERFDYQSDAAVFCTLLRTASTPLQVKVCELLVAYLKAAHVDNDLVDNDEGIQSAESLLSFYRLLHDDLVAYALPNVKAGDQCSLFLCNLLSICSSRRVFAEIVGMFGSSVRSLLPSGTPGGMAPELPVDNARRVIGIMKTLLFLTKAFGAPTVPSEALCAIASSIITGTRTHLCRLYSYNVLAFLLRNITDEEEVKAVLPDLSASQLRRVLALLKEANHLGDTTSWSFQRKARASAASPIQAPASTAPPRHSETINTVVPSDSVAGSPAVPAAVQQLPATPLKPTVAEKRSSPSMPTHLMSSATTDTANVAVAAVTPPVVRGNNAGEALSESAGTTCADSTVVTTATATARGVARAGNRPPMNRASSTNSTGAPTTNRSVPTSNHVALAPSGESQSSSVEQFKAEWLKRLSSQFTYSGQNTKSGSYDREAWKAKRDILTSVLDQVRRVACRLSMGPSGTQVVGILESILRFESAIPIVLGALQLLGVLLDKCGEGFMRQVKTPCLVDLVFDRLKDSNGKVQGAAVQCVAWMIKYGDGAMVFEAVKKSLCHKSPLARIAMCNIISGTAVLPDSFDNITQELQCHRSQLIPVLTSLALDKNAKVRCAALESKRALEDPSYSRPSAKPTAAPSAVIRPAPPTSCPRVTGGSSRATSRLRPKAGTAAPPAGLKGPSGGAPPVGDAKKEIASAAPPTTPDAVPAAVAPAKRKLVRRFLKKSLRKHSNGAGVTVPAPCVTATSSCETAPTETSTYSVPSDAMEVDPPVSSTSVAMDLDETVSDDMSRSSALTVAPTEDQLSSNVVYSSNFEDGDSSTKNLPVNSQCGVVATPLESSDKRVMPAAKETRVCPVPPRPRLSERISAEEVSTSFVPSEAESTLLNHIDSSILNKICRRGSSRRSLAEGLYELSKWLNGHSDLARELEASILRFLCECTNNFSEQSKTGKAALYSFLEDFIAPGVTSDSAAMLVAAISTDVRNPKVASLIKQLSSNCDGDTFFAALLTDGNGSTNSCDSSAMLEFVLTLLTPELVANLNANTVGIIVSYCARLSSADGGDVSILAAKVLDAIDAVPTQDVDEHLSPAAEVEAVAQSPKSDTLTASQCDSSPLPAPGYQPTSTASSSVSPINDGVLAAAFEKCLPSAVRDSNKVIATPSPPTGRSDGSSSSCYNSFELPDKFSNALLFASMRMRKKVSRDLYCCMFESNGESGLNRACMFWETFLQQPRDLLSGMLFADNNVRLELLTWLCCALLRGLCENQVYRCFDRLFAKVKEMGLKLSVDESARVLDALTIYRERNQGNALLLFDHLMQVTNVTTELLSACFSPCVWQAALCERMASPIVPDSLPSTQQASQVSPQRVSTVVRSEESPKTSSPSGIACTSPANTCNVVVPEGTEIPEKSPINGDAMECQNLSVTSISEDQDVTGRNSATKFRVSSVRTSAERGSKTPCDPSPASAASAGIENNGFIPSNKAEQWIKMNGDISTVRHSVGAVAVAPTSNIKSPSKPAAASSKSIVFTSASAPPSFAATSASNTRKRISLVARESPLSPKTLRSSQSAQQEYNEQSPCVSTGSPVAKQQGTPESLTPKRSKLPDAPSTDVVMESSDKVVCDAVMDNVGAATGKMSPDKSTNVSPIPIATTNPRRSGTEERRSVTFALEGGVRCTPTAEICPSETHAEAVAAVADTNLSARRCIEDEAANEVVKKVVRETVLDVGNHISQEPLDLGQEDHDEDYGSFPGDAPPNGVCRSHTPTTATMSDVSLYAGSVSDLGASSPTCNKREACDIGIQTTPLVNLIAQDTHESILPTGVIEKGAEDVTVALGSVTAVDVADATTTSGVAEGANGSDIGSDTTKSAVTDDTHVSDVVSGAVYPDVVSSASSAAVESARSSVSRILSRHLRCESVESECESSMLLRRYMKMVESILSDCSYIANFCLLSNYQDYHGLVPSFYDEGIIESCLERTARILENLAVFPDQQVVSALSPVLVDACHISILRLCKEVEDFSRLGVSTDKVVEAIVSLIELFTIASERLDGRSLLQYCAVVIHCLALPKVCFHRNVKLYNGLSRLISVNALEQGVDVLSRLLVICVELSVQSLRRGDGGRILLAMLRLTKILQVQVMIRMHYKKCMSPLTRSELYKSHSTYVGMLRDYLRGAYCKPTVEPRLQEAVRQSSILLRSLCESGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D575</accession>
    <name>A0A061D575_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA branch site protein p14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0104330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766310.1">
        <property type="nucleotide sequence ID" value="XM_012910856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D575"/>
    <dbReference type="STRING" id="5866.A0A061D575"/>
    <dbReference type="GeneID" id="24562665"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104330"/>
    <dbReference type="OMA" id="HQPDKMV"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000432">
        <property type="entry name" value="Splicing factor 3B subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="122" mass="14084" checksum="481BAB4080DF3D3D" modified="2014-09-03" version="1">MIIGTSASRRSMRLSPEVSRILYLRNLPYKISAEELYDIFGKYGSVRQIRKGNSPRTNGTAFVVYDDIYDAKNALDHLSGFNVAGRYLVVLYYNPTRLNKRKDLDKEQEELDRVKSSLNMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5A8</accession>
    <name>A0A061D5A8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histamine-releasing factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0210240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768057.1">
        <property type="nucleotide sequence ID" value="XM_012912603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5A8"/>
    <dbReference type="SMR" id="A0A061D5A8"/>
    <dbReference type="STRING" id="5866.A0A061D5A8"/>
    <dbReference type="GeneID" id="24564412"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210240"/>
    <dbReference type="OMA" id="CAMITEG"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="182" mass="20385" checksum="40FF54978865A468" modified="2014-09-03" version="1">MLVYKDLFTGDEVCSDAYAHLNPFDNADFANVAFEVKSNKVAKGNEDYGIACNDDNGLNALSEEGGSSGPAADPGVEMVIDVVDAFRLQETPFTKAEYTSYIKKYIKRVATHLEENQPDRVAAFKTDIQNFVKHVLSNFNDFEFYIGESLDLEAGLVYAYYNGEEVAPRLVYIKDALTEERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5B4</accession>
    <name>A0A061D5B4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768067.1">
        <property type="nucleotide sequence ID" value="XM_012912613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5B4"/>
    <dbReference type="GeneID" id="24564422"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210340"/>
    <dbReference type="OMA" id="STARICK"/>
    <dbReference type="OrthoDB" id="365308at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="877" mass="99448" checksum="DA478AF581B505BF" modified="2014-09-03" version="1">MLRKRLVFKIVKDALSRKSLRPFKHIQESFDHHLQLSLDLIDKRQTICRRLEVGDNVYDRVPSHEGAQNHTSGERKDHTGADLDVIGIDVLKPFEIVMGFQVLAMKCASEVAKLEQIEDHEKFRYRLHALLSLACHHIEGFSFVRLSLILNSLANIIRWHRDVTDSRPPNSGGDRMGRNDFCSVPADRLDSIFGGKFSADPEGNDLELTFKRFHALLETRFMLHLCLYEKFGASRTHEDPDVGHIDAHSVCLLLKYYLVVGDMNRTLFYLILRFIRQQSQFELRDVMNMVVSLSMMDGASDLYSPVDLQQLHAAVSVFMEHNISDPSAINLSGESSSLPELWDNETVKNRSLVELLLITLAEKEPTGGADLHLCHLYIKALMVFRDRGVPEELLAALASDALKNSTHVFSSGDVLKGRGFDKFVAYLQSIKICVRDSSILEPAALQSFFLDEQVQRRTLSSLLRLAKEPSNTNVKSLVTLCDTIKFVSAIKNTAEDHAALLTHLRSTLSRVLPVIVLANINRFKVGDIVAVYEYLHDDMPARMEVQKMLFNLYANLNSGDNTPDVLDIYTETTTLMTSFHKHNYKIDHAVHNQISSWILGTYKIAGIKDVSLLLRFLQSTARICKIEPEIFIIYDFNILLNYVFEFDVWKGHVIPLVDIIYNLLPHWANGFTDALMKSNLVKLLEHYHLSTIVPMAVQSCEGRPSGKDPNSDRMSPLDISTFAKYTHLVWSLRNTSPVSHELWDRHQTVIVDGIYNCTNIGKLSLGDDGPVCSNKNTNVKKCEMWQSFSVRLMVEILLDMHRQHLGSSGADHSALPKEQRAMSFLCRELLIGLDVFDDHAASMTQLLTLILENEEHMPDCPHFTDLVCKLNSVVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5I7</accession>
    <name>A0A061D5I7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0209460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767979.1">
        <property type="nucleotide sequence ID" value="XM_012912525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5I7"/>
    <dbReference type="STRING" id="5866.A0A061D5I7"/>
    <dbReference type="GeneID" id="24564334"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209460"/>
    <dbReference type="OMA" id="MMKQQEP"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TPL/SMU1 LisH-like dimerisation" evidence="10">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="313"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="531" mass="58913" checksum="7B841785B76FAFFF" modified="2014-09-03" version="1">MDKTVKVASEDVIKLILQYLKENRLSKSLMMLQEEAGVSLNSVPSVDSLVADAQMGRWNQVLDAVDTMSLSQETLFKLYDQIIRELVDLRESTLATAVLENALPMREMEREHPDKYRILADLCRKRPAETREIYASSHDAVGQQPLTKDKRRAIVAEALKSEIDSVPPSRLTALLGMAMKWQHNVGIISSGDQFDVFRNTSTTATRGDEPSVKEVAKIIRFADNAHPECAIFTPNGQYLISGSSDGFIEVWNWHLGQLDPDLEYQNKDQFMLHETLIVSLAVSRDSEILASGDKDGHIRIWKIATGECVRKMNNAHDGAVTCMTFSRDSTSLLTGSFDKTARVHGLKSGKPLRTFKGHHSIVNAAIYSYDGTKVITGSSDGYVKIWDSRTTDLLKSFLAFTGSDPSSGLKPETPRPVNSILSLPYTGGDELIIVCTRSSSLSIYKLNGICVKHYSVEETAGNNFLDVAVSRKLNWVYSVGEGNWLYCFNKAGALEHSFKVHDKDVIGIAHHPQDAVVATWALDGTIKLLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5N1</accession>
    <name>A0A061D5N1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor 3b, subunit 3, 130kD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0204600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767488.1">
        <property type="nucleotide sequence ID" value="XM_012912034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5N1"/>
    <dbReference type="STRING" id="5866.A0A061D5N1"/>
    <dbReference type="GeneID" id="24563843"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204600"/>
    <dbReference type="OMA" id="PRATGHW"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="15"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="445"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="838"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1169" mass="129317" checksum="F669FDFD8461ADCD" modified="2014-09-03" version="1">MPVFYHLTLQKPTGITQAVQGNFSAPKAQEIVVARSHTLELLSPDENGKLRSLCVCEVFGIVRVISAFRLTGTQRDYLVVGSDSGRLVILEFCNTARTFKRVHCETYGKTGIRRIVPGQYLAVDPKGRALIVGAVEREKFVYILNRDSKANLTISSPLEAHKSRSVCHDIVGLDVGFENPIFASIEQSYEAVDALQVDDDEELTDEVLKKGLSFWEMDLGLNHVARKMTLPVDLSAHHLVAIPGGESPGGVLVCCENFLVYKNMDHPEISCAYPRRLEMAQDKPLLIVSSAIHKMRDFFFVLLQSEYGDIYKVELFHEEGRVKEVVCRYFDTVPLGNSICILRAGYLFVAAEFGDHHLYQFTGIGTNQNDPLCSSNHPQGKDAIIAFKPRVNQNLQLIDELSSLSAITDLKVIDVQGLGQPQIFLGCGRGDHSTIRVLRHGLSVEELADNELPGRPKQVWTVPTGVDSTHDGFILVGFEGNTLVLSVGEAVEEVTDSCFLTSITTLHVSMMGDGSYVQVHDGGVRHVFDMKVREWKTPTAKRVKVAASNKHQLVLALSGGEIVYFELDESHTLVEVAKRSLNVEITCVSLQPTAAGRLMANFMAVGALDNLVRILSLDRHLKQHSTQLLPNNSTPESVCLAEFQVAAHPTLMLAVGLNTGVMIRATVDAISGALSDQYTRFLGSRAVKFKNIKNQIMGTSDRPWLLYEYQGVMQCVPLSYDTLESVASFSSPLCQDGYVAISGSNLRIFRCCRLGETFSEHRLQVDYTPRRLVLMPNEAPTQGGLNYMLAVVEADHNAYGPESVAEIGQALEGIKLDNEVGEPMALTNFKAGTGKWGSCLRIVNPLNLTTAAKLLFENDEAATTAAVVVLDGMQCLCVGTALGYDLTNADEVESYIRVYCYGANFEIRLLHVTRVGGVVRAFAGYEGRLLAAVGKRIRLYSLGKKQLLLKAEHRTCSDHGFIWLNTVGSRIFAGDIREGLQVLRIKFYSEEAADFEWVGGATGPRWLTCCTQLDYSTVIAGDKFDSMFVARVPQEESTRHIQLENVCQFHLGDLPTAIDKASLSPSTSVVLYGTIMGSIGAFVPFQSKDELDFLQHLEMLMSTEAPPLCGREHSFYRSYYVPVQQVVDGDMCEQFRHLTEAQQRKVAQQLDSNVNNVLRKLDEIKNRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5N3</accession>
    <name>A0A061D5N3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 8 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768044.1">
        <property type="nucleotide sequence ID" value="XM_012912590.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D5N3"/>
    <dbReference type="GeneID" id="24564399"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210110"/>
    <dbReference type="OMA" id="FRCFATI"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1732"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1876" mass="206140" checksum="C2DEB16B8304A432" modified="2014-09-03" version="1">MARYSLEELLRATDLSDDSDAEPSDGSASTLPLGGRAAVNYNEVLRSYLQDRDSDCLSLSPGDRSPITPFGGVKGTDTGAWNTPKGCSASTDLTSTCVNSISRATSLTVTRDTGSFSPPRRSNTSPLSDRKEEQTACNDAEQPSKPEDEGGAERGASAQGSECNCVAKYASAINKLTKSTCPYFTAIRSMILQQLQTPSNIHRLAHIYNLKSSSSGDILQPSDDENEADSDSFHEPLPTLYPSKTCLDSLGISLKRMKPPDKPDLLIRLRHNVSIALEKLRLFNDDFINIDAAKVSTTATSPPKSYSPSCIAVSNHVLVVGTSGGSLLVCDITNHRTRRQFSPHNVDVQDDEAGSEDELVWQEIDRQSDASVTCLDVLPESNWICAGYSNAMVKLVQLNKDAVSAKSADALKSDSADGAASADSVPPSRGFGLMAGAVSALGGFKKSGAHVICSAKPFNDAVAFCKFTLGESHDEIFCANRNSIALLTYSKTVLSHNLNVTTLDAFSERLLEHEEIVDVACLSSNPQSKFITGVPMSGLVALATIKRCIVIATRPELSILFRVPFTDRPKAAQGSDCTIPSITWIILNNSGDIKPVLLIVLSSRISFTLCDLSAGKRGGPPVSCSHIGYIRFDHAIRHVYTVSRDMFAVVDYNNVMHILQVNVFDNVMHYDVVRSFDFAEAGLAEIWMDRVNISPTIAVHVRTVKMAAHSYKKFSALVSEMFQGKRNEQHFDLRVLSFYISTSQGIWSSEIHSWIKSIGDLTATKYFANAFAISLGLCIGMLPGLLDYKAYVDNIQKLILYVLHQSSAQIIRLSKLMDTAQMASIDDEDNGGWTDKVKDDISTQIDTLCCCMLDICLCLGLHDSLNDLIYRCFATVGMQRVFVKYVLLNLHVGRIDLTRLKPAVFDSIFEFYEKMLDNLLSVGCSQSGQVEDWLVSLCDEVDNRQRGQCPKQLPRQAAAPDARVIVYGTLCNQLSRLYIFCSRNEIPFAKEKAICTLSKHSQWHAVVHCPELIGDDIAVALEILYSELSNRVDKLRNVEGTSSRELSASPWDQSEGLFVTRVFFSFVNSFLTFANCGMPQDNAATNFCKVLGYLTSSASFKPSFPITSDVKHARPELSFEDETVDFDNMDLLSFKAANGSALASPALQLLISTCPRLLFACLMNLLMAPDSTFEAKTDLLGTKIEIFNFVLESLIACLSTLEGSQSTCTVRCMMSMFVLGVSAFSDSFYISLRTQVVAMYTLLTEVGDVNRDPFLDPAELTSDELILPDGSFNNAYYLHSFCKRSDDLLENVRQFNMSSSTTRELLKLYIRRSLVAIYRKYDCEPSWTHNVHFANMKRICMGLQELAGDFDTRLFLCDVAADYANAIRACESAGSEIVFSYLRQCLNCIKSGPNSGELRVNELVLSDPAVQKEFVATLMDALPRLIRVDMQSATALLVDTLSVSNMASVFKETALHSSQDLIISTLGDFPELKMAVLDALLGISSQDSTASNDKEAILSVLPGLENYFVQYLKLLCDHDPRGVCPFLKRQRRLDFGTCLPICMSANIHDAVAYLFMRAGDFESSSRWLLDAFHASGDDVEMCHRLIGDAYELCQGFSEFTSHESLEKLWFSILRCTVDIESKHGAASTLIERVFNVGILKFTRLTRALGELEAYESVAVSMFKHPLRMLLCDVDFQTFAARASSTMGTTVLCNEFRKSIDCNKRGVVVEGGAELRRDHEICGVCRRKLWSTPQSDTGGGEDPPPAEGTLRGDASPSTTAASNLSPLEKHLGIIYTLQAPPNKHAPHDSGSRASNLHLPHLYQDQLSTLLSMKPSAGGLGRAKWITSTSGLSSAMPPELRAHIRGPASHSTVQVYWCGHVFHAACAPRRCATCSAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D628</accession>
    <name>A0A061D628_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767658.1">
        <property type="nucleotide sequence ID" value="XM_012912204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D628"/>
    <dbReference type="GeneID" id="24564013"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206300"/>
    <dbReference type="OMA" id="NQTKHFG"/>
    <dbReference type="OrthoDB" id="365036at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="174" mass="20083" checksum="73F6683B52502482" modified="2014-09-03" version="1">MADEPGAARTRRPSSGPRKAPIVDNFVLMFYNKDGSAPAYSSADCAGSLSSEASFREKVRDYLERIKELRREITDKYHAKKLTEDKMQALLFELRVQSRFSALNVKKRQAVKVHLQRKLLLCEKIYLLTIRLQKLYIELAELVDSRASHCVQLHRTARRCASALYEHRRRMAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6C5</accession>
    <name>A0A061D6C5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766670.1">
        <property type="nucleotide sequence ID" value="XM_012911216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6C5"/>
    <dbReference type="GeneID" id="24563025"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107820"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600639" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7645" checksum="768862095DE22839" modified="2014-09-03" version="1">MLVIVIVVSQFATQILLQIAVRDGFTVDAYEELDGFAKGYGALYQKVILLRDVNDLYSHIAEKLKTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6E2</accession>
    <name>A0A061D6E2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768309.1">
        <property type="nucleotide sequence ID" value="XM_012912855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6E2"/>
    <dbReference type="GeneID" id="24564664"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300280"/>
    <dbReference type="OMA" id="QIPVYCR"/>
    <dbReference type="OrthoDB" id="365526at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="451" mass="49002" checksum="2D67DCA4AF490866" modified="2014-09-03" version="1">MWSLSRDSSANGAEGRASVLDTLLLRSATDDVDVSSKGYCTSVETDSATPYLSSDASSNRVTGSHVTTTLSPTNSREPRTPTTRSEQLAILLARNYASAPACSLEFVNLTSSLRDSRETQRDSDITLLDNCSCPYARQNSTTQSPLNEDPSPSSQDQWINASGDEEPTENTDDMPLDSALVDENGCEDTQSVERESSRACALMNMHEATQAVENGVEDGIETTCYPLGPLVRRNCVDVGTSPMPPSPGEPEPSPPTSHAVEAGTSPIESVKKSIPVYSRSLLYRIRVPLAQRLRNSCSTLGGSLPSPRRSSVQRTNMSCERRSVSLRLSIQETATVDIENERSASTVSFSATSSDLGSTINSDNASSEGGTFVKRVRCLQHRREGKRRRASRTSPNRGILVSGELWPNGTMKYIGPDRDPGQENSHGDDRISLLNQMLARHYYLCTAPPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6S2</accession>
    <name>A0A061D6S2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768429.1">
        <property type="nucleotide sequence ID" value="XM_012912975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6S2"/>
    <dbReference type="GeneID" id="24564784"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301470"/>
    <dbReference type="OMA" id="CECINCD"/>
    <dbReference type="OrthoDB" id="365614at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="651" mass="71500" checksum="59BDD7FB8B266584" modified="2014-09-03" version="1">MEKHEGNTASRPKIDRKRIQMSLERSIEAHRLRMLKARTSKRDMPGSLCECINCDATSMKPSMTCRKAGRQKQQKEINRERVGGFIHDVSKASSPANAQPSRRQPRYNASTRTRNVATPKANAHVPGSKKSPRKQAPEEVPNVVETPHEKGGDAYDGSIAPSTAGELVVNEANVEQKETEIVSSARQSAVLPTNACESSTTLRESARQECQGDSSRTNENSDSLLNRIARRIGSIRIVDSMGEEHRLDTDELENKILDVVDKIVNDKIVGKNAEETVVQKDDVEAQKTDEPVNVSYTPVDHCSPKNDMMNMSNVESEDTALSPKRGEFIVDEPTDSVPMNKYKNVVDVLLDYISCGVAQKPKTTPDVLKQESYVLAGPESACTNKVVSKTTDYVYSTVEKPGLFSSVFTRGETTKRSNMCCNGGGGRYASMEPPSLGVNDAVSTGGVLGFVKSNHMAFRKDAVNIAPSRQVSQASSIRNDAPLMNGAPNRNHCVPYANHANMMINGHNPYHFQYNQPQFPCNQNSVFLPQWPAAQSFQNPCHLIRPAPKMTDRQFTAPQRGQALVRRNVTAVPGFNAVKNSQRTPGSMPNAAGVPFASYAGTHRSAMANRSYMPFGNVPSPMMAVPRQATGVLYRRNTGRAHEQQVQAAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Y5</accession>
    <name>A0A061D6Y5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD-REPEAT PROTEIN BING4, putative or Probable U3 small nucleolar RNA-associated protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0303700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768652.1">
        <property type="nucleotide sequence ID" value="XM_012913198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Y5"/>
    <dbReference type="STRING" id="5866.A0A061D6Y5"/>
    <dbReference type="GeneID" id="24565007"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303700"/>
    <dbReference type="OMA" id="EFLPYHW"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="254"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="7">
        <location>
            <begin position="338"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="543" mass="60375" checksum="1B58E1E098F66973" modified="2014-09-03" version="1">MAAEVRDTKVFHAKFFGGKAEKFKQAQAQRNVQKYKKVHKTAKAEADATSVLLPNQAGFLQVGEDEKTYNVSQAQILDAVDVGTRRKSFSLQLQHGPYRCDYTRDGRYMLLGGEKGQLALFDAIDMKPCFDISVKQTIRDIQLLDNHELLAVAQKKYVHVYDNNGVEVYCLRDLGLTYQLEYMAPFWLMAAIGEFGELSWQDITSGEVVARYKTRKGPCKVMRHNKDNGVIHLGHTSGVVTLWTPNEGRPGVEMLAHKGPVVSMAVHNHYMATSGFDGFWNVWDLRNYSKAVSRQFTGRTPPEAMAVSQTGILAMAIGGRVEYYRDAFSRVGGAESSLYLKHQFPAESARDIKFQPFEDVCAVGTTTGVSTLLVPGAGIANFDAFAPNPYEPSSKKQVQRMLDKIPYDTITVKNVEIGAYNRDYTAAESEEGASAPAATVDSGGEILKNTRKKRRSMKAKTASKVGSIGASDNSHQVAAYERTFQRRQQAARDRLRNLRKQKVAGQEAKQHIIDAMTFEDSTGERRVRGSVRGAALSRFAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D736</accession>
    <name>A0A061D736_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0302320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.5.3" evidence="1"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768514.1">
        <property type="nucleotide sequence ID" value="XM_012913060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D736"/>
    <dbReference type="STRING" id="5866.A0A061D736"/>
    <dbReference type="GeneID" id="24564869"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302320"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="10001" checksum="F77BE6E42385606F" modified="2014-09-03" version="1">MLKPIHPDYPYLQGEVLYGIRREYACTPLDILARRTRLAFRDHKAASAVLDSVCDIMSKELAWDGARRSELRSKATEFFNSMEIPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D757</accession>
    <name>A0A061D757_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768737.1">
        <property type="nucleotide sequence ID" value="XM_012913283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D757"/>
    <dbReference type="GeneID" id="24565092"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304540"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="10083" checksum="DDE12920B1DEF93A" modified="2014-09-03" version="1">MSPVAPQRAGSDECTCKKGDNEEPGCDNKKPEKNESGGKKPCRKEKGNMWDVYGLLYRRLSYNRRNHSQLYIFRLLEFDSNLQKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7G8</accession>
    <name>A0A061D7G8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765861.1">
        <property type="nucleotide sequence ID" value="XM_012910407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7G8"/>
    <dbReference type="GeneID" id="24562216"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100040"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7706" checksum="5C0FE44A4F828E40" modified="2014-09-03" version="1">MIFNSARPIKHHENTGVLHSTAAAAVICDTVWAMPHHDGPDAGDKSEHITYLPFIRGQIMRIFTTQYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7G9</accession>
    <name>A0A061D7G9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768113.1">
        <property type="nucleotide sequence ID" value="XM_012912659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7G9"/>
    <dbReference type="GeneID" id="24564468"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210770"/>
    <dbReference type="OMA" id="GVKFMFW"/>
    <dbReference type="OrthoDB" id="364807at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="115" mass="13520" checksum="477D1362259101D0" modified="2014-09-03" version="1">MLLNTFRGRAPLLAIREARRFRRQPVKLIEKVTEEYEKAGIESTAPKPDESATERRKRMIRYVYYDPTLSQKLAIMKARFLATGWIWVVTALTTYTALNALYFANKHFEKGRYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J1</accession>
    <name>A0A061D7J1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0304170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768699.1">
        <property type="nucleotide sequence ID" value="XM_012913245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7J1"/>
    <dbReference type="STRING" id="5866.A0A061D7J1"/>
    <dbReference type="GeneID" id="24565054"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304170"/>
    <dbReference type="OMA" id="CIYDNFG"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.54.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="587" mass="66488" checksum="7272B46BAFBB936C" modified="2014-09-03" version="1">MTKYECYFDSALHIIKGAACIAFSLPTGRTTKSISRKSTTAGVMTLCSVKSQPTDSQYTLFNQLIEQKISENGKFRAMLIDRPVAEAVYGDSIYDERVVPANVNKLRLVALEEWNVNASMRDVVKTTGQVGQIDINKLTYKGESQTLLISFVVQPGSDTPDILTETETIGSPAECPPKSMVLPPGEVDMENDTFIELFGLERSSNAAKPANEIDYDKLIREFGCEKITQKQLDRIEKLIKRPVHPYLKRGLFFSHRGLDHLLDAYEKGIPFFIYTGRGPSSDTLHLGHLVPFLFTQWLQEVFQVPVVIMLSDDEKFLFREELEYDKVREMAKENARDIIACGFDPNLTFIYRNTDFIGDLYGISLKMQKKTTFNQVKGIFGFGMSSNIGSIAYPAIEGAAAFCQAYPKLFGHRNDMLCLVPQGIDQDPFFRMTRDLAPRLGFLKPISIHSKFIPSLLGVNCKMSSSVEGSAIFVTDIPAVIRSKIHKYAFSGGRDTAEEHRRLGANLDVDVAYHYLRFFLEDDEELNDIATKYKAGEIMSSAVKDKLVEIVCNIVHDYRCRREQVTDEVLDTFMDPHRECFKKFRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7L4</accession>
    <name>A0A061D7L4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein p1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0305900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768872.1">
        <property type="nucleotide sequence ID" value="XM_012913418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7L4"/>
    <dbReference type="STRING" id="5866.A0A061D7L4"/>
    <dbReference type="GeneID" id="24565227"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305900"/>
    <dbReference type="OMA" id="REELMCV"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="118" mass="12268" checksum="55AD13E589138C50" modified="2014-09-03" version="1">MASVPMSQLSPEQRDELLCVYSSLILYDEGLDINAENITKLINAVGVKVQPFRPMLFAKALAGKNIAELFAGVGAAAAAPVAAAAAAAPAAGDAKAESKKAEPEPEEEDDDMGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7L5</accession>
    <name>A0A061D7L5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger domain containingg protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0200410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767070.1">
        <property type="nucleotide sequence ID" value="XM_012911616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7L5"/>
    <dbReference type="STRING" id="5866.A0A061D7L5"/>
    <dbReference type="GeneID" id="24563425"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200410"/>
    <dbReference type="OMA" id="ICFNILY"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="394" mass="44505" checksum="C6C5AC67E8FFA47F" modified="2014-09-03" version="1">MSLLKDFECPICFKLLFRPVTTVCGHNFCKACVDQVTAYSSKCPICRAALCMEYAPNTLLMQAITELFVNEVREREAENLATAQAEEARFRRRCGEQRFDGEGYLPVLYCNRRNPPMFRGEETSFVMRTSDVTQLLQFSMSRGGMLLVLCDDGQNTQYGALAKIVNTELGTAAADDHTPFTVRAKGVERVESVGTAVSSGHGWFTSMYRIMRDDFIFPYSQEQNESEALIRLQHAVTQKSISRESLVPEFNDTKALAGKALTDMDRYRLCCQLLQLCAIIARRQLQDCSAGARRLFTSQFSNLMVVGDDPTSEEVETTSLFYARLVVASNDEKWRWYTMRDPLTRLVEVADIFVHAGDSCVLQLQANPTYKLGIFWSTLLLLVAAVLLSKVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7M1</accession>
    <name>A0A061D7M1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCI domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0211340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768173.1">
        <property type="nucleotide sequence ID" value="XM_012912719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7M1"/>
    <dbReference type="STRING" id="5866.A0A061D7M1"/>
    <dbReference type="GeneID" id="24564528"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211340"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="354"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="473" mass="54044" checksum="0C275E0A7018903E" modified="2014-09-03" version="1">MDSTVSELLSVDSTFRDEPRLEDLSDLASKTLDIVESMLKNTATRDVEFLKTVLLELMLVEKRCRMARDGASNARICTFIIQLLYDIRDLPNVSYYLILLSRKRGQLKVAITAMVNLAKSWIVEIPDMESRVNLIDTLSHITLGKMYLETQRAEVAFTLARIKEESGDIAGAANDVHNVEVDTFGLLPKQDKVRYLLEQMRLHLLNKDYLRFYITSKKINESLLDAEEYSAHKLKYYEYMIQYHLHEGDYFEIAKAYHKRMDTSIKQGGAGWILDMECMLLFLLLSPISEDTVKYREDILATKEKNMKETPMLTALFKEFLSNNLIPFPLEEDIGSAVKAHAVFSDTNLPGGDVRLAALSDRVVQHNILVVSKYYTNVQLARLSELLNVDCAKLEEEISSMVHAKTVHAKIDRPAGIIRFGERKSTDAVLNGWSKDIAALIGLVDQCSRLVQKEKMIHEARLKQVELEKTYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7M9</accession>
    <name>A0A061D7M9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribokinase like superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765911.1">
        <property type="nucleotide sequence ID" value="XM_012910457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7M9"/>
    <dbReference type="STRING" id="5866.A0A061D7M9"/>
    <dbReference type="GeneID" id="24562266"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100540"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052700">
        <property type="entry name" value="Carb_kinase_PfkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320:SF3">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595531" evidence="4">
        <location>
            <begin position="24"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="5">
        <location>
            <begin position="96"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="365" mass="39925" checksum="484AC59564BDC402" modified="2014-09-03" version="1">MNASIVFAAVAGVFAASFSSADAFLLNGTEVMEDGPTSILFAGDAFMSIGARVSNEILEQFNTARDDKTKPVHELFEAIETKSDILYERPGDLSATAALVYSKLGGQVGFIGIVGDDDMGDKFNDYMGDNDVEVRTIRRGGNYTSRLYSLVDENGSYNVFKAVGACDTVSAADVDPFLMDYYDFFAVTTDMLRTAGRTGFTAKMVDAAINRGQKIITILTDVVFGDYDSEMLKVILHNSEYVVGSMEQFIAIYKVSSRDEVADILHEKTSGDEPDHEVMLVTLGAEGFALFYDSEYIYVPAPEVAVQRADADDYFIGAMLYGMLNGRKLAETIQYARAVVTDVCSDISAPLSDNFYNLITDIPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N8</accession>
    <name>A0A061D7N8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768892.1">
        <property type="nucleotide sequence ID" value="XM_012913438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7N8"/>
    <dbReference type="GeneID" id="24565247"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306100"/>
    <dbReference type="OMA" id="NFAVCFS"/>
    <dbReference type="OrthoDB" id="10495058at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595533" evidence="1">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="7901" checksum="292B7E9C46907B81" modified="2014-09-03" version="1">MNFAVCFSAFVALFSTLFAVPAITTPAEDNKGALKEFMVLKNNDRFVARSYGTFSLPNVLPRKQEAEPAKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S2</accession>
    <name>A0A061D7S2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768228.1">
        <property type="nucleotide sequence ID" value="XM_012912774.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7S2"/>
    <dbReference type="GeneID" id="24564583"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211840"/>
    <dbReference type="OMA" id="KYPRCAS"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1705" mass="190691" checksum="098808DA6F5A97F2" modified="2014-09-03" version="1">MATRDLFDNDDAHGDESDDSFIADSEVESDGSLASVKGAGESVDSDFEFLFGSEPKPEAKKTKKSASRWQKELDRRMREASAQYADIENVESEVAFNLEHLSSHFERRQGVESEMLTLFSGLLTREQFTVDSSSPTDDGSKAADSSATQAPPQETDRALNKLMKKLIRSTFRGKTPEGRFGNLVKANSDAPKPAAPGKVSTVVTIGREALSNLQDLNTLLSREREGDYMELDGVPLYKHTRYGTLYIFESGFVATHLLPLCSKLLHEASGNDHDFQALTQEVIYVLYQLSQPPTSAWYNYWTEAQPHYKAFAVSKEYDHDPNVASELKRRARIVWHYLNGLVAFRSSLMSSDLWTLIGEFRLKLENFERAGHRTPEQKQRVEMLQRQQDSLANERDALLAEAASSGDDEDGENEEGGHPTGRGRLRKDRSTAEARKRRVQELRNQLYEVNDELAKERHAHMEAQQQTRIHCKTVRLLITHTLTIPGDGLGLLCMLQEGGLISLLRDEVVSCFNLCKRGFTVSESDDIHAHPAYLSEAQRESLWEYVRLVHAILVCVDVNRFLGLVYSGIRPAEMKVDDVLLRSTEEQANRSAENEAILDLIRLNPKLARMTLRGPANLGKFTINERFQGTRSHGSYEHWFRFPSLTHLQTPFEVSSGVSNSTSGSRAAGSFAAAVVKSLQSELHQLIGIDCDFEHCHWSDAAAASGIYYELGLVLSLCFGDLMREAQDRYYQQSDYQVVLDLHTWVVTYYRCMYLYLREQCRTEDRQAPPEAYVLLALRRYIGADSSCAKVACAYVWQLIRKHSLSKASHFGATSALRALYADLNLFQMIGDIRSNVHVMSICQETLAAYFTSDIRAILFWILRYFKMLSQPSNLFCFALANLHLLRHVVRAVGSVSFTHENSRSDAIGRDSDSDSSDDGVSITKTVIVTADSVFSSRNRNTANDDILYNGRVVYNCVAMLANFRTNSPHLNDMLVSHLESVPLPMLYDIKYFYVFRDIVGDRRVWQNAKWRWIGDYCVRVMESFFDGWLGRGNRFLPLELFFNKCSPATKGPFRPCAPDNITPIMRGYEHCGLLSELLQRPEATVYEVVREKRGASGSSTWDPEEDAALLKYYKQFRFLADPVAYIAELLGRREADVQRRLEELRVPTSEPQGAKGGNTAALQKLLRNLVSLFADEAIKVCAELHENISESIEMQRLGGADAVCEVMEPLSASPRLLGSAEFQAVLHCLGISQNWLLPKNTGDLAPLMAVLDDPSSYIVVGKERAESASQSTPETRATATSAAAGESVHEDTQMDTDSGVSQPAVVTSKDIAELVLRLIRCLEEHGESANASGIIQSAINLVESASVLGRAEAVCSYLPQREECLSRVRNLLRLAEVEVRPPMIACDSLPNAIIAVDRLRVAINLSRLPASRLEMIVQTNVHQPSGSSKRPPSSMAVDTDFEDSFEKHMDGASDDQHEDHLDLDAPVSFNIFGLRPGRGKKRGGGQRSSAHSGTGRGTHVRRKMSIDSDGLSETQSDHLSIPPDEHGGELRAVLDELRRRLLLGHTRIDAADLMGIGIFDNWDAAFDMLRRYCGSLGASEEFVANTLWLVWPEDNVDSAITALSITPLSAVQPEELSSGEWGSRAVRSVPVRRNIRRRVDHSPPQLGVQCDGEPPEPLDLEPLERLEVNPDLVASIYEESLRLAREGRLRNTVTSREDLERLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U1</accession>
    <name>A0A061D7U1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768937.1">
        <property type="nucleotide sequence ID" value="XM_012913483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7U1"/>
    <dbReference type="STRING" id="5866.A0A061D7U1"/>
    <dbReference type="GeneID" id="24565292"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306550"/>
    <dbReference type="OMA" id="TAKIHFW"/>
    <dbReference type="OrthoDB" id="364016at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="425"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="475"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="70010" checksum="78B557FC8D9BB2D9" modified="2014-09-03" version="1">MASFLRITAPRWAERALSRRVFRSADDCYSLLSPGSCVETHELYDALKFLASGVSERRSALSDDRFGEILCQVESRLPSLNSSYMGNFALRVAAIVQSSGSSAPGTGPANAERGRSLLSKIAATMVEKGGQPRELAQVAYAAAATGADSESIFEYSKQQLTVEIDSATPDALNLALQTAYKRGSRDKIYYALLCEKLCELTDRFTANDVMHTLRALAKTGLLKGFLLRRLSTLIMDNLDQFSAAQLAEACYRLSQLKFLTPANFSRVFAAIEPDLNSLADHLRLQLLAAGCLSEREDRSALERLLDSLEYKSNWDLSGCVDFAYSSAYLRRYGEQLPHVLTAISERQPTLTRKYALLLKEAVDSFEVEKVPVTFDLGPRWRDVLTTFEKTESELTQGTPAFQEVRKILQGASSNFAESQTVGPFTVPFLDSERKFAILIEFASNMSNLRVKMRCLEALGHRVGVVRYWEWRRLKTERQELEYAFRLFDSRRKGSLTFLELKSLLSSIGISLTRNELSYLQMGTFTPAKCANGRCVEEDIRGGFILEDLYALATSVYTDGVIRQRLAQSLQAHFPKQEKVSRKDLESLLYKLGRRLLVDPAEIDACLNVYCSGGNGDQISISNFIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Y6</accession>
    <name>A0A061D7Y6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765991.1">
        <property type="nucleotide sequence ID" value="XM_012910537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Y6"/>
    <dbReference type="GeneID" id="24562346"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101340"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="23919" checksum="3B0A13F9897951D9" modified="2014-09-03" version="1">MVYTSLTNVPRNFKEAIDWLMAVRGDGAKSNVAALGAALFSSLADKTVDKMEMPALEEVKHVTKKFLDQPELRNQWFVGGLVKRYNDLINKSPGGLAKYFRVVDESDENVLKGKGITAGSIVENLDDVVYGTEIFLDDIKSPGEYESAYSPEATCSKSCTQKPEDCAAVFELIQALGYVEPECRAGMTASYVGRALSGFDADTTDFICDMSGFWVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D853</accession>
    <name>A0A061D853_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0307550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769037.1">
        <property type="nucleotide sequence ID" value="XM_012913583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D853"/>
    <dbReference type="STRING" id="5866.A0A061D853"/>
    <dbReference type="GeneID" id="24565392"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307550"/>
    <dbReference type="OMA" id="EIIVIHK"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000133">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="27"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="712"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123692" checksum="490B7ECDF47E8EBA" modified="2014-09-03" version="1">MAQGSAASATFLPVDEKVDFPKEEEAILRHWKEIDVFHTANKLASGRPKFTFYDGPPFATGLPHYGHILAGTIKDVVTRYAYQTGHDVERRFGWDCHGLPIEYEIDKLNNIKHLSDVQKMGIGVYNEKCREIVMRYSGEWREIIARTGRWIDFDNDYKTLNTSYMETLWWVFKQLFEKGVVYRGFQVMPYSLACTTPVSNFEANLNYKDVTDPAVYVAFRCVDEPVELVAWTTTPWTLPSNLALIVNAEFVYVVLHHEQRGVDYVVAECRMESFCNDARLVVDKDVRVVRKLQGSELVGKRYEPLFEYYASEPGFDEEQLSRSYVIVGDKMVTADAGSGIVHAAPYFGEEDMRVCKRNGVIRGALPELIDESGNFKSHLQRLGGMYIKDADSEIKRMLKERGRLVHAGTLVHSYPFCWRSDTPLVYRAVSCWFIKVEEYREDILRCVEQTQWVPRFVKEKRFRNWIADARDWCVSRNRFWGTPIPLWVSEDYTQVVCVGSIEELERLSGRKVSDLHRHFVDEIEIPDPRGPGFKPLRRIPEIFDCWYESGSMPYAKIHYPFENKESFPQCFPADFIAEGLDQTRGWFYTLMVLSTHLFGAPAFRNIIVNGLVLASDGKKMSKRLKNFADPVEVINQYGADSVRLYLISSPAVRAEPLRFMTDGVRGILKDVILPWFHAYRFLVQEASRFEVVTGRRFVPSASAAVDSSCVMDRWLHSITQQLIDGVHREMGAYRLYNVLPQLLAFLEQLTNWYIRINRDRMRGAFGEDESYVSLASLYSSLDAFTCLMSMFAPFTSEMIYANLKRAAPGRMESIHFEMLPRVSGVVDEEITFKVRVMQQVILLGRTVRERRRVSLKTPIAGLKVVHEDERVLSAVRELEALVKDELNVMNVELSKDVSCISCQITPNFKALGARLGQAMKPVAAAIKGMSQAEIARLESEGSADVLGHTITLDDVVISRRIDVGALSHPDIDGDSNREVAVLLDFTSDESLRWKACAREVANRVQKLRKQLRLSVNDSITIYVQPHGELAFEKLSLQTEYLEKTLRRSVVVTREVPAAGNVHSDTFELGEQRFSVAVEVHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8B1</accession>
    <name>A0A061D8B1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0301220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768403.1">
        <property type="nucleotide sequence ID" value="XM_012912949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8B1"/>
    <dbReference type="GeneID" id="24564758"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301220"/>
    <dbReference type="OMA" id="NYYRTKW"/>
    <dbReference type="OrthoDB" id="430533at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="6">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="200" mass="23401" checksum="CD3C41F0A07EA9BC" modified="2014-09-03" version="1">MISLKFWGGGAERFCRCFSTRSYKQGTKEVIHPYVSHPEQLGLISRYATAMPRGQQVYIPKNFYNDLTDEATRSGDFLGSDFPYTLAGKEKAWRTRKYNVLANPVPNNISSAGCVTYYHRLQVWSTHWFENGLHRSRWFKCSYGFHRAKSAAELFRNKLISFGRVDNKKTNEQIRLESEKLRSLRVLRSRRFDVNSNRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D2</accession>
    <name>A0A061D8D2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0203310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767360.1">
        <property type="nucleotide sequence ID" value="XM_012911906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8D2"/>
    <dbReference type="STRING" id="5866.A0A061D8D2"/>
    <dbReference type="GeneID" id="24563715"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203310"/>
    <dbReference type="OMA" id="MGREPDF"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="315" mass="34943" checksum="B7C93E16D5980311" modified="2014-09-03" version="1">MTSLSRALLDRRRNVSSPLSLFLKLSKWKLSLWVSATGASGFLMKTPALSPDFFYACGGVFLCSSAAHVFNQIMERKTDALMVRTRNRPLPTREITPRGAAVLGSASALAGSSLLWLTGDSVAAPLALMNVALYTCGYTVLKRYTEWNTHVGSIVGAIPPLIGYAAAGGSIMAPDPWMLFGMMYVWQLPHFYSLAWLHRKDYLNAGLKMFGTTDESGRSTALASVKWVTILTSMPMVYSYYGLISPSFAIVSLLPNLFVNYRCLRYLDNPCKEEARAFFLHSLWHVLMLVGLASYYVATENEDVKKKDRISSRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F2</accession>
    <name>A0A061D8F2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidylprolyl isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767380.1">
        <property type="nucleotide sequence ID" value="XM_012911926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8F2"/>
    <dbReference type="GeneID" id="24563735"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203510"/>
    <dbReference type="OMA" id="PEYALDQ"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600687" description="Peptidylprolyl isomerase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13992" checksum="5A16EF001B881BFF" modified="2014-09-03" version="1">MFLAAPFLVLATLLGLNYGSVLAYDPEYALDQTELSGEFSVRVLKPGIDGSRSVASGDRVKALLRTFSPSVPKHITGFAEQIFEVGKHPVVPLNNAIANMRLDEIRRVGIPFGEYGKIFYEVHVVSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I5</accession>
    <name>A0A061D8I5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0309240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769207.1">
        <property type="nucleotide sequence ID" value="XM_012913753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I5"/>
    <dbReference type="STRING" id="5866.A0A061D8I5"/>
    <dbReference type="GeneID" id="24565562"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309240"/>
    <dbReference type="OMA" id="YLMRENC"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="796"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="939" mass="107033" checksum="EB3AFCDEB9252DC7" modified="2014-09-03" version="1">MRHQDKDTMFNSTHPEASRHRESGSGGRDHVTNRGMDKRFHEYLKDLRWGVPHTNYGGEAGTRGSTSDKKASHNRKEDKSRDSRHYDSSINEEQRKRMMRLHATVPDSTFAERSAARISKNRLRRHADDTYGKMLYTTSVEMFRNDNFFQEAESSSDNAFSIRHDSQTSTDEGSPVVVENEIHYSTEPEAARSKSHRERSPYRWHPESDADPNSAEVKPPVRSAREMPNHNDNDYIFDVEFGYEEPGHASAGYAGAHSMLERDYSGLVMSLRAMADQIESMASAREAAQRENERIRRALYSQLHLKNQELARLRNQAREHESERSDLEARLDALEAKLLRLKSTRRADRPKDQEGADGEETDDSNYTATMPAVIIDADELDQRRRSYITTLKTYLYTSMDQSSNAAFQSELYRDLSSMPEVVRCGDLVDFINDGIRSDADVLHSRLRHSALRHGINRIFTEGHLPAATNRYPYPQEFERRVVDEMESSHPPRRFSMHGTAKSDAQREKMGVVMNRLVLLSILKHTDMGTLYNYLFTALYYDNFRAVEILKESVARRFLDFQLAPTYSARVSHPMMWSFGDSCNATQAYRYMKALDFNFATFPTDPHNGDNLWHRVAKGDAVAVVQTLKPYAIDAEHISAPNHHKETPLDVAKGKVRVELMGLAVVQKAAKGSENYRDNDFEAALKMYSEAIEMQIEVLSIDGGDKVATQDVNLGKLYYNKARSLMHLDRWTGAVEACELCVQHIPSYTNAYATCIQAYEKLLDWGNAAKTCYLMRENCGVFDDEKMAALQSQLGATMFQILGVSSTANPREIKQAFNQLCKQWHPDKINLDPANVDLKRRAMNQFNRLYEAREKLLDDSARKVEQSKPETPYKHPEPIVDASGKASKGAEATAAKIEPLQHHLSKLKCESQDDVAVDEQLLQTAVDRIQQQMNEMHAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K5</accession>
    <name>A0A061D8K5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766266.1">
        <property type="nucleotide sequence ID" value="XM_012910812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8K5"/>
    <dbReference type="STRING" id="5866.A0A061D8K5"/>
    <dbReference type="GeneID" id="24562621"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103910"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="324" mass="36847" checksum="CAD697D11166A7F7" modified="2014-09-03" version="1">MTLPQLQYRYNQPFYKLSTALTSAKRSGTAFAAPTCLPRPPLLAGDVSRLNPVKSYLDTQGLVASSVRALTAPLRSPGFATRDMEEDIDDWQDLSVEDGDAMRWIQWFASLEGHEFLLEVDEAYIRDQFNLCGLKSMKNYDSAMDMILGFAPSEEVFMDTSFLDLYRSATDLYGMIHARFITSPMGLQMMKEKYQQGVFGHCPRVRCQRQNVLPVGFSDTLHNHRIKKYCPRCQEAYIFKYGEAHADIDGAFIGRSFPHIFLLTFPSLIPEDPPMPYTPRIFGFKVHNINSLIQIKLENGEFGRLPLANGKSHDVNNMEDESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8P2</accession>
    <name>A0A061D8P2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768493.1">
        <property type="nucleotide sequence ID" value="XM_012913039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8P2"/>
    <dbReference type="STRING" id="5866.A0A061D8P2"/>
    <dbReference type="GeneID" id="24564848"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302110"/>
    <dbReference type="OMA" id="MHIHYAV"/>
    <dbReference type="OrthoDB" id="361580at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592:SF15">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595914" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="3">
        <location>
            <begin position="365"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="460" mass="51390" checksum="6DE9449F086B9354" modified="2014-09-03" version="1">MSISRWRHLGVYLSLIWYFVAVCDSLSTTRTAKCVLGGGQGVERCVSRYQPAFLNTALVPVESRRNGRTHGSQMPQKNDRITTRKSESHLCAISNDVGLYDVLSERRKAVSKIICHHVDRALQKLKESTLCKQLKHVAASAINRMSALSTKEQIGLAILGEIIYAFYLPNFHILFPYQIIPVNSGLGVDVGLDTITSIVSGYYLWISMQKPVPKVTLNLRQKFTIPLVAAGLLGSFYLSGYTAQAVDNGMLLFSAMDFPISVALQRSARILISHLSWVLVGAKMLSHIMPLKGTNTEWFAMNPKDLWVYKALAGYFVSCTIYNITDVVFNAAQALKKKLAPNETDVDDEMMEGVLIEPSELFPAIIASLGPCLTAPWWEEMLYRIFTFKALNVKLPRRMATVLSAFIFAAHHMNPRSLLQLFGLGILWSLIEQGTNNVFVNIAIHSMWNTRIMLGTLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8R7</accession>
    <name>A0A061D8R7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769119.1">
        <property type="nucleotide sequence ID" value="XM_012913665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8R7"/>
    <dbReference type="GeneID" id="24565474"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308370"/>
    <dbReference type="OrthoDB" id="345965at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="171" mass="18912" checksum="C1F16E78152863CF" modified="2014-09-03" version="1">MATPGEEPSAGTDQQDNHKRCIPYIAAVTTGTVFWGYIITKRVNRMLIGRYDDVVYQIRRAESLSNRFKAFKLFTIGGAVVPAVTLAAAYVAGRRQDKSEEQLSKQLRDEAVAASKAASSKLADCTYNASKRLERIADGVKGLGLEQAGQRMANDLRNDIQAAKRWIKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8V1</accession>
    <name>A0A061D8V1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <ecNumber evidence="7">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0303010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="7"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768583.1">
        <property type="nucleotide sequence ID" value="XM_012913129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8V1"/>
    <dbReference type="STRING" id="5866.A0A061D8V1"/>
    <dbReference type="GeneID" id="24564938"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303010"/>
    <dbReference type="OMA" id="SEMIHNP"/>
    <dbReference type="OrthoDB" id="1698201at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.20">
        <property type="entry name" value="4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426:SF0">
        <property type="entry name" value="4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595574" description="4-hydroxy-3-methylbut-2-enyl diphosphate reductase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="403" mass="44334" checksum="268F7D13F6C19699" modified="2014-09-03" version="1">MYGVIFLALSVLSVECLSVHRPGFVLRKAGNAFVVRDHRFGGRWSNHAALNQQSTSLEANVCEESGSQTRDAPAVANSSKTLYLVNPRGFCEGVRRAIRTVEEAVRLFGPPVYVKHEIVHNEFVCNRLRAKGVIFIEDLETVPEGSTLIFSAHGVSPAVKELARKRNFVEIDASCPLVNKVHVYVKKKAEEGYKIVLIGHKNHVETIGTAGEAPGVTTVVETVDDVDQLDYPEGTPLFYATQTTLSLDDCKVIKDRLLERFPWIETIPSGSICYATTNRQTAVQKVCAVCDLMLVVGSTLSSNAKRLLETATVRNIRGYLIPNADAVTEEMIGNATRVAVSSSASTPEELTNGVVEKLASPPFNFSVEFFDGGEERVPKWRLPRNLETFIKEHDSKTEAAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8X8</accession>
    <name>A0A061D8X8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769347.1">
        <property type="nucleotide sequence ID" value="XM_012913893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8X8"/>
    <dbReference type="GeneID" id="24565702"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310640"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="14228" checksum="D31FDDCB2CB342B6" modified="2014-09-03" version="1">MTGGRTWMSGAPCDKKKPCPDFTKCKCTCCKKKCAEQADKCSPPAPPAPQLPPDSSHAESDSFSQPQPFISEDHIQESNSPSNPQAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D903</accession>
    <name>A0A061D903_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769367.1">
        <property type="nucleotide sequence ID" value="XM_012913913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D903"/>
    <dbReference type="GeneID" id="24565722"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310840"/>
    <dbReference type="OrthoDB" id="366746at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="356" mass="40133" checksum="B360000F32041F89" modified="2014-09-03" version="1">MALAVMMACGATAQVDDKSRTNSLNDYLGAYVNGKRTVYENSKRPSPHLEKHIFVTNSAYLKNKKYLLEDILASYQRPHPVKPYLEKFVEYLQSTLVEAKEDSLVVFKPSEMCANSLKMLWGVIHLLKERPHIKHDTLDIHSTGVHFKNPTKNTIDKHIMDTLLLICQQIYAQCYTEMEIFVKQDLPNDHQEVSSNDSPRSLGDGGNTVGSHEAITKGASSADSSALPSSSWADSKTAPLRIKRSMDARKPEPSVSSQEPGPSGVNPAPSDDDKQLQRQLSEGESGPAEQDDDKRSHNPPHNKIDENSAADWDEYNESYWNGIRKLREDSESMDESGEPLSWWKRFLRSMRKRSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D913</accession>
    <name>A0A061D913_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0309410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769224.1">
        <property type="nucleotide sequence ID" value="XM_012913770.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D913"/>
    <dbReference type="GeneID" id="24565579"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309410"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1588"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1661" mass="182957" checksum="4C1B784AB3E7A7DC" modified="2014-09-03" version="1">MTKIRISTLKECFEFLEWLNGRQGQKNNVGATFVQRLTPYFQQMSKHKGALQFQYNTFLSNVSTLRTKLLSRDVARLGNYNVNTGDKNHILDALLECIPKFLAALYYLQYHVDDTYTDVGGGDWASESTNSGDFRKFLTSGNNILPCGFSPVELSSVKGSALVFDLKKILHKEVNRSGKAVHDHFRNVVLTTLGKPWNNFNTGNAVLLVYAFCQLVMQESRYDGGAFKTALETGLIEHKICWKDLKDHCQILHGHIDTLTAAGFSVTGRGIKPTRKEDFAKVAAKWFRDNLPTAASVLSEMIPHSVDISTLRSYAKDKLYPNGFIFDGSNHSVWPSLTQLNKWDPIFQKFGQLDEMLGRLKDILEGKNIVACKPIATKTEAAKPTATKTEATKTEAAKPVVTKAEAAKPTATKTEATKPTAGKTEATKTESTKPVVTKAEVTKTDSPQPEAQNVENTQSQAKKAEGAQNQGKKSEGAQNQGKKAEGGQSQKGQSGDRSSSLQAPNPVAAPASDAKGYKGDAGSAGAKGQMPTELSQSQDTSHKQVAQQQQIQQTQSPASPPSAPAAPSPAGPTSDGGTIPKGSDSPGKHPVSSTGVVYSAAPGVPPPDPLPSAAGAPGSPGASGMTSNNGDSPASQFVTTTTAVITQPPSISNPGTPSHGASGSSGGTGQVGQAGASGSGQPRGQEVQTGKSATPTKSTGPGAGTVRGGSGGGAGAGDTRMVDPELEERLKVYEKLLKEKKDRDDKNMQTILNKFNENLEQIEQQKMQQQMQNDLQRQLLANISSANIRLNENIAGSTGGRTLNWHHPYDPKNLTRRLQAVNRLQSHALDGREVWNKSPSDLYMEKRHEEWERQCEEEQRKKDQTYNDTILHLKNRQDVDKERIQLSQKQHEQTVLDSLQSMQQIEHENAKITSVATGLDGETADTFDVKEVSDADNEVVFDGQRAVEIEGQEVHDAEEFLKQQKQDAEQIRSEAQLVASLYDRQQKTLLNGNEVLEPFNVEEELFQPVAQSDMDLYKPNGDISTAISNIPDVGMTGHAITSPPEVDVKIQSVPVKPEYMPDPILPDFDISIDIPALLVPESLEDYDYGPSYRLPTAIGRDKQDANTFDPPRLASERGIPLFANPYVCRDPWSVTPYSPDTPPPPTSPPPTSDHLPPPKTVREMLFWFVGLNQSGYIWMITEHVKDLLMSNNTDALDVIREPFTLDASHVAAKLTETCLYSANVLYRIKYRDDCAAYKEFKLESVYSQLRYSPDPACLLCQLRDYVYACHYQLQFLKSQCKRDKLSGGWQDYKYGSDITSSKSPLQSFLTDGWDSTFKTHPFDPCNLCHKSRIRMGFRDKDLPKSSQQGNVISSILTPSCGGSDPLLTLASYLNGLTRRTPRTTGELVSFFHHFGIELHDYGQKDLSPLGKSLSTPHPDCPDWDHLGRHDLQAVSGIRGSEILTTIHNSKHDHADTLSTLVGCSSDATICHPHCSPITYRAYALYSHTFAHTYLSWTVYLPDRLWESLEKLYYELKKHDYAKCSSLYLCSTAPPLLYLHGFTPPEVGSQPKLTCSDVIAKLQEIVNGGPIASLMTAMDNFLYGIREPFIFTIVALWSLAFLIFANTMLYRLDVLHIRSHLIRTKASHLIDVKALLTKGRKMLSLYKDVDYFDEDPIGQLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D924</accession>
    <name>A0A061D924_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0205520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767580.1">
        <property type="nucleotide sequence ID" value="XM_012912126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D924"/>
    <dbReference type="GeneID" id="24563935"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205520"/>
    <dbReference type="OMA" id="QCSAYPK"/>
    <dbReference type="OrthoDB" id="20534at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF50">
        <property type="entry name" value="RING FINGER PROTEIN UNKEMPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="398" mass="43979" checksum="9D74CDE3808F0D39" modified="2014-09-03" version="1">MSNASYRGRGGKRAGNRPQDGNLYSEVAKGEHKSQAASDGMLVVGSASNETVPSQSASHGRKQIQSHQNSDSEGAKHATKKHRVLSEHELANFRTSFCTNHHQNKCPNSDSCEKSHCLTWQRRNPYEISYSPQLCPEIQFVKKSRKMVLYRRCTRGKNCNFAHSKEEELYHPLVYKTKQCSAYPKCTRYFCPFVHASSEMRDVTELKSTGLVMPSVSSDNADKSLPATSPSHEAEPGATKEHEEGSEVPKTGDDMTAGLWYEPPSLSAICGYDDVTFKNLYGYGCAGFAQLPTDDYAADFDIQNCVAWQTFSPGNQFDAPLMEHFVDPTRYAGGGDFDALGGVPQFSDGLGGQFIHFVGADLEDQFGALSLHKLPDDPLESYPLNDVLVKFMNDIGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D970</accession>
    <name>A0A061D970_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766451.1">
        <property type="nucleotide sequence ID" value="XM_012910997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D970"/>
    <dbReference type="GeneID" id="24562806"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105740"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="7079" checksum="8DB244B0C40356D9" modified="2014-09-03" version="1">MPCKNCCGLKSVDIYSVRKIGFNAEHLSERVLSPKTGSKECQTKKYLRFLFDMFFNSNVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9D4</accession>
    <name>A0A061D9D4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766491.1">
        <property type="nucleotide sequence ID" value="XM_012911037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9D4"/>
    <dbReference type="GeneID" id="24562846"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106140"/>
    <dbReference type="OMA" id="RTIGRCI"/>
    <dbReference type="OrthoDB" id="366318at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056316">
        <property type="entry name" value="Microp_apicomplexa_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23483">
        <property type="entry name" value="Microp_apicomplexa_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596115" evidence="2">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="115" mass="12919" checksum="C750B4CDFCBA1689" modified="2014-09-03" version="1">MYFHAHFKNLLRCLAVVLLLRGASTPAAAEPEYEDAFDYDVVIKRIKDAAHYLTDCTIDQLAQYCTTETALNFECFRTIGRCIPGTLRKVAILGGDKGADEEEEEEEPISESEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9H9</accession>
    <name>A0A061D9H9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0312240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769507.1">
        <property type="nucleotide sequence ID" value="XM_012914053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9H9"/>
    <dbReference type="STRING" id="5866.A0A061D9H9"/>
    <dbReference type="GeneID" id="24565862"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312240"/>
    <dbReference type="OMA" id="QLHTIMI"/>
    <dbReference type="OrthoDB" id="365492at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="4">
        <location>
            <begin position="250"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="3">
        <location>
            <begin position="663"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="829" mass="94292" checksum="31644AD8437DBDAC" modified="2014-09-03" version="1">MERALRNFIIILAIDITVFVASVVIWCSKRTKIIVLIQNSLQGLHLLNRKKQKEHTQSDNRRVTVDDVKYRVTYQSGYASSVTEADNDGSSSAENGDEDSSNEASAATLMYIERKKKKPSAEGGRATSSKKRKDTWWYYLYHGKHNKIRNNEAVLYLGFIRSTCIMLLICSAVAIVSNVVIFTHLTVNNKPHFLLTYSIEDLRTCKVTVWTLYATTWIYSIIVYVHILKFKQKVNKGKQITVMLRPQLHTIMIFGFDKTITDPGRFYRYFEKYFPEHVLSVHVVFNHSKRMALEEELKATKAQLCLCRDMSLLVDRSREAYQHSAVTSTSGKEAVDGRADADVAPKKPRRSRSCGMLPEAEMKCSLGQTAPLRNCASSVNQGGTPRNCASSANLLSLPKPAKPEPKKPSLAIPKGFTRYVTRMLGKNDCELQEAGDAENLEYLGERFAGLLKKVKELKARIEQELNREHTTSARICFVSFADSNIVLHILKDRNLLEGMPTWRIVPAPHPRDIIWQNLHLPRWYVATRMVVCNLLLTIFYIVITWILSHLNLLHTVKSKDDRNPERSFSINDLTERSFWSSIMPPIIMAGLNSFVHPTMINLLSRQVGFWTQTAHQKYLLFGHVKSSTGRSTRCRWSWGPSSSTPRGVRSICIYFFKFDIGVTNFDLGYWYAFHLSILTLVMLFSLFIPYLLILGTLYFAVRYCVDRHNIAYDVLQLPLDSTGKIAASAVKSMLICISLTQFAMSGVFLNCQEVLPSTCITLLYIASVATWLLLYESNADAVVEATESMHKIKLAPLTKKMMDTIKLCYMHPCDAKDLIDGRVTQRNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9P2</accession>
    <name>A0A061D9P2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768883.1">
        <property type="nucleotide sequence ID" value="XM_012913429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9P2"/>
    <dbReference type="GeneID" id="24565238"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595939" evidence="1">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="128" mass="14551" checksum="270C6C8F435E853F" modified="2014-09-03" version="1">MAKFRNMTPLEIFCAICLYCLRGIDASVCDFGGPDQLLGQNDLAICHKYADFLKFETVICPRHVDGTEYAWHPQSTSADHYSLFKAYIGANYRCSSRFTFDNSKLNKEPNLLPVEMTLSLIMRIPTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA45</accession>
    <name>A0A061DA45_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769589.1">
        <property type="nucleotide sequence ID" value="XM_012914135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA45"/>
    <dbReference type="STRING" id="5866.A0A061DA45"/>
    <dbReference type="GeneID" id="24565944"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313060"/>
    <dbReference type="OMA" id="FRCDLYA"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="302" mass="33467" checksum="CD8E0753FDF4E16E" modified="2014-09-03" version="1">MDELPAVLQGVDLLAVLGVEVVEDADVAELRRGLRRTFLRRAKECHPDKQKPGSKGSDTSLEFARLKAAFDYLQRDDVFATLYNRALHKKREEKARKERTKGISAKQAAHLDALLRREREAAEAAAARREQFHPEKPSQRGFQASYEDMFDAHAASSSQAGPASQQGMLFVAARTMKIANEAELNCLLLSDHFSNMFANFGLLRVQPIDITETAADAVNVKVGILVFQSHEHALKALLHYRKHRSNFRCDLYALALKPQGDPAASAASADGASAESESLEDMEALVLSRLRQAAAKRRKLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA87</accession>
    <name>A0A061DA87_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766841.1">
        <property type="nucleotide sequence ID" value="XM_012911387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA87"/>
    <dbReference type="GeneID" id="24563196"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109530"/>
    <dbReference type="OrthoDB" id="366245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="105" mass="11654" checksum="ABE394136A62AE40" modified="2014-09-03" version="1">MCMLSLFDNLKHADDKLIIYASPNSATAIERLLCERVLSNANVHAEALNLNSRIITIQCKSVTAQFLSAESTKRESVAFIKSVLDRPSLHAHLSQALIEVLKQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAF3</accession>
    <name>A0A061DAF3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleoside-diphosphate reductase beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769867.1">
        <property type="nucleotide sequence ID" value="XM_012914413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAF3"/>
    <dbReference type="STRING" id="5866.A0A061DAF3"/>
    <dbReference type="GeneID" id="24566222"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401730"/>
    <dbReference type="OMA" id="KENQFRW"/>
    <dbReference type="OrthoDB" id="2093646at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="330" mass="37311" checksum="2BD23DD8167F6A93" modified="2014-09-03" version="1">MEPDSVQYLTPKEVALGQAHESLLEDNADRWVMFPIRYEALWAMYKQIENNYWAAENFRFIDDRQMLLSLDVELRECMVKLISYHARLDYRKGARPAEVTLDLLSDTQLPEARAFYGFQVSYENIHSEVFGAMAMELAAAADVAEGDAKIEWLSTKFASAECFYIKVFLQCISKCVFRCAFGIVKDYLRMTGLLPMYVSALDTVDTDLAIHLKFAAAALAQLKLRVSRDVLLALLNEALELEVKFCHSVLPLRKLGLSEGQLLQYIQNSMNQCLLIAGQPEAHRIDADFAWLNPPTIDVAITAKQLHQSKPKIVPVVEATVGAISFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB27</accession>
    <name>A0A061DB27_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767116.1">
        <property type="nucleotide sequence ID" value="XM_012911662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB27"/>
    <dbReference type="GeneID" id="24563471"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200870"/>
    <dbReference type="OMA" id="IFLACVM"/>
    <dbReference type="OrthoDB" id="364875at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="606" mass="69334" checksum="296B5A77A0EDEB8C" modified="2014-09-03" version="1">MSYWSQGKLLVSAVHVLLFLVGLLGVEIFLRVRRKWSLLGHSTGRAATYQDDIIVEDIASQIEEHDLLSRRKIGAFAFGLSFLACFGFVLIICTKVLLSDNSDRSFLDLLWAADVIICKIIIFYLAPAGLCHKYINITSELRAVHRISRVLLFLLVWNCISWAFTRAMLSELLVLKTQADTSTVILDALGVSGFGLAFIAVLTGFTSVYVPYRVYVTRKDVLTTTQVDNRIADATMAIQHLREEILKQRDPLASLVAECSEEESEDEEFEAEPTGFFRTSHYMDRMEQNSSPAISTAPEAQDATSDPSCATYAPEEAQAPGAPTGVCRSVLRRVNGYLTNVVRNPWRWWRHTDLAVREATNQNSVHGLMRLQAYIRQERAYLLDIRHHRQLWNSKFGRLRIMVRYCEVLWAVRTVLVVSYRIIKISQAPYAETATREGATKVMAHVYHLYIKDNFVRRLISDVLMRSEPPSYLDLTLSRISALLLMIITLANLDHFFDFCRILLNTQYFQKRRLLTDNSLGLALSAFLVCSVPSQFCLMIPFLPESQRKSALQFMFEGDILVWLGLQHRFDLFVFVTIMFMLIGVAIMHHRRPKYYALRDRIVCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB69</accession>
    <name>A0A061DB69_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767166.1">
        <property type="nucleotide sequence ID" value="XM_012911712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB69"/>
    <dbReference type="STRING" id="5866.A0A061DB69"/>
    <dbReference type="GeneID" id="24563521"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201370"/>
    <dbReference type="OrthoDB" id="366412at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="485"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="876" mass="97028" checksum="0F91554BB58E80D0" modified="2014-09-03" version="1">MENDETSSSSDSPADRSFEDARDAASGESTDSEDLEANTEVVKNIHFYPFAESQENRSPYRYGDSSDDNGCDRQGSDDEDTSSYDSSPHYAAAVEPSAFKHSSGLRYTAVPGYDDSHIYGNSNSSASDQYSIEEGVGRKLTGEDSIEESNSSGAITAEDSSAETDQTSDEDGSGGSAYQPVDDAPNTQSPIAASAVGDNNVREPVSSCSTELRCRILQGEIRILRNEKADWLERERELVKRVQQVHEDLKEQRKKLLDRQRKSQALEQEVELLHCRYKTRQETLEQSYKTLCENVRLTDLASLKGRLDLRRLQTKNMLLEELLQTKTADYERLKSMASQFAWPADMQMKCAPSSEATCGSSKSDDTAMSTWDGEVGQHKDPVHDGAAIDSGNADASESRPGGDCTTENEPDQSCEPPEEHDAMSRGDDPAEGSRSDSGREEHTAYAGDVAEPQQIPPHSSKGVETLHELSQLMRIHLKQMIGCAKEAEKQMRESVDAQIEELKELLQQTRSDLAYKTEECNVLSRTLEGLRSELDIARSNLSHSIDEHRGIKEKYQCKLLEVEKLQNDLDALLLQYEEVKRELSSTVSQGRQQRAAFDEYVKDTDMKLHKMEVLLSVGGLAGASVGALSETAPLGDTNEPNEDAEADATESPGSVKDVDIHNTDFAAPVEGYSNVARRHPAYQQHQACMATRTNNPARNEEIQLQRALASCNTHLPDVRESDCEACCVNGTPNPETQTDHMNDGVENTTPSSVSQTGAIDTGKMQEIFKGVVVRLLKKVETLTQTLTEQVVRAFKSEQRVKELESGLKPVCLCRKSLERVEATKRKRCWCRYKRVAELRRNVTHSALLLDKNTISAVLAGEMSCKKRKVAPPDTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB4</accession>
    <name>A0A061DBB4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767221.1">
        <property type="nucleotide sequence ID" value="XM_012911767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB4"/>
    <dbReference type="GeneID" id="24563576"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201920"/>
    <dbReference type="OrthoDB" id="366824at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="8659" checksum="9817E6FDE728FADB" modified="2014-09-03" version="1">MRELLNDGFLLETLGEAQAIAKNIEALLNDPVISDINFYAVGSGLDPYDATILNIQRDYDLYYDELKDLVNAWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBE7</accession>
    <name>A0A061DBE7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768410.1">
        <property type="nucleotide sequence ID" value="XM_012912956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBE7"/>
    <dbReference type="GeneID" id="24564765"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301290"/>
    <dbReference type="OrthoDB" id="361772at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="184" mass="20991" checksum="BBAC8161990842D2" modified="2014-09-03" version="1">MGLTTTISVHLRVADAFQERHRKDNLNETESTNICGKKVQGVAFLTTDKNNPAARCNVTLLLENKTLHVLKGNTDLKRFVVGDIKTPVLIVRDECLSIQNDISEDVLCFPNRYSLESWWMAITKQILCNHQGKVRNEMYGEATLEEIHADVESLYKGDQRRGINIRIDGDDPSKLPQIKVHYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH1</accession>
    <name>A0A061DBH1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 86</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770074.1">
        <property type="nucleotide sequence ID" value="XM_012914620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBH1"/>
    <dbReference type="GeneID" id="24566429"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403760"/>
    <dbReference type="OMA" id="FIDISHM"/>
    <dbReference type="OrthoDB" id="365935at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15398" checksum="720E4B963697D77E" modified="2014-09-03" version="1">MTAGDDSLSIKGTPLSGRVWKRNVRPCRALSKTGGDRSAEERSRQKWAEAQAMKREMKEISAETSEAIQKAQELRKERLRKLREKRAKKQANEIKSAGNEVVLVSNKKVSKMTKKARRKLTKVTPEMANILLRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBP4</accession>
    <name>A0A061DBP4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0404695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770169.1">
        <property type="nucleotide sequence ID" value="XM_012914715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBP4"/>
    <dbReference type="STRING" id="5866.A0A061DBP4"/>
    <dbReference type="GeneID" id="24566524"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404695"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404695"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="181" mass="20405" checksum="ABE0279218A42205" modified="2014-09-03" version="1">MYSDTGSVNNDGRSFMDVGVTEDKVSSNATVCDVETPKSNDGPVLFGRYSASFLKERGNVVFKSGDYFAARELYTNAIVRLEHSENDALAAQLYCNRAACHIAMDDFDSAVSDATEALMLDRSYVKVSLRFKFVVRRQTYITFIIDVIVKHLYGILCSRWLKYEGCNCFSVTDLLWETKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBS2</accession>
    <name>A0A061DBS2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0313150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769598.1">
        <property type="nucleotide sequence ID" value="XM_012914144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBS2"/>
    <dbReference type="STRING" id="5866.A0A061DBS2"/>
    <dbReference type="GeneID" id="24565953"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313150"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="84"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="351"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="615" mass="68993" checksum="EB490CE275FCD2D7" modified="2014-09-03" version="1">MAGPGKGSKSSGSSMSESKLRIAIVSSDKCKPKKCRQECKRNCPVAKTGKQCIVADPTSKIAFISETLCIGCGICVKKCPFEAITIINLPRDLGKDTTHRFGPNTFKLHRLPVPRPGQILGLVGTNGIGKSTALKILSGKMKPNLGNFTNEPDWPEILQYFRGSELQSYFTKILEKSMKTAVKPQYVDNIPRQVSGRVGEILEAKDKLGRAEDLIVTLELSHLMNRQISELSGGELQRFAICVAVLCDCEVTMFDEPSSYLDIRQRIIAARVIRDTVQHDRYVIVVEHDLSVLDYMSDYICCLWGKPSVYGVVTSPFSVREGINIFLDGFVPTENLRFREESLCFKVAADVDMEEIERLHNYKYPEMTKKLGTFSLTVRAGDFCDSEILVMLGENGTGKTTFIKMLAGILKADNAEAEDAMPRLSISYKPQIITAKFDGTLRQLLMMKIKEAFSSPMFQTDVIKPLQVEELYDQQLKNLSGGELQRVALILVLGKPADIYLIDEPSAYLDSEQRIMASRVIKRFILHQKKTAFIVEHDFIMATYLADRVIVFEGKPGVNATAMSPEPLVVGFNRFLKSLDVTFRRDQVNFRPRINKHDSVKDKEQKTSGNYFSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU1</accession>
    <name>A0A061DBU1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromodomain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767406.1">
        <property type="nucleotide sequence ID" value="XM_012911952.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBU1"/>
    <dbReference type="GeneID" id="24563761"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203780"/>
    <dbReference type="OMA" id="GTSMDHL"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="1536"/>
            <end position="1586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1617" mass="182053" checksum="7EE4C6E60F759F4D" modified="2014-09-03" version="1">MAAYELHSQDVSVALDFARCTLCGSTQLSFVRRDEGLPPASVSGGPFILPISVPAIAHADYKRVVVNGIGADFQLAKTLDPTSNASLVNQSCRNVDLLSLDGMHVAAQQICASLLYVELSEVPAKLKVDIQFEYMQLRSATDDLYFHSYWLLPRCSTSYHEYAVLCSSPKSDRWFPTVSFSDTISMASSCVYRIEVVVPSGFSVICGLPLCEETTVGDGVEMAAKTTTFQFKWESSSSLGVFPRNSFGLFAGEFEFWDGNRLQETHEVSEERPHKSLDDEDCVEAFLQAAQHKLCHKVPITYVTLKGYGFLLEPSNIATAQCVDTYRRVLDFEAPDSFFMLFLPGQPFPVPGNISANIRTQNFIDIKRCTAFTGSENHLYTSFIEPLANYYHGMYYPSGANMIVYSIDVLHSYSDIDHDFRSLDCRIAIAYGLATLFTLKRWVNPSRDMHLDVMLQSYLVDQFVKRNMGFNEYKVRMWARRELFATITEIYGDYHPLCQRKGSSASVPILMADRAFVLKCHLLPAILEALFVSANFLPDNFLVQSLRRRVVIFSKVGDDDLRADANCARRGEDDDAITTCSNGAVFWDTLRDEMVRRYINSWNARPPNRLVVENQLDPNCKLEDILRRGVDHDHLSAIMKQYNSIVSSFLHGTGCPQINVSFSLQLQRKGTSMDHLNFRIDIKPLQPPIDVHKDGRTAYTVAMGSQLAARNLMTTYGKLARILQLDDHTEEHSGGHAGQVLERVAQIYNICKSGYCPSVPHAFDFVDIANSTPIPGSSEAGILRRNMGLLQIWHDPVDLVGRDGNFLMGFGYIGPFPYAFCLGNGPIYDCLDVLKKHCDVNNIIDSYVDNGGTYCGSYVYKNGYELLLGRASLPVASNGGMPYWQIIHQQALMNGQTEPVPMSAGLSKQWVAQVKVDIVEDDGVRENVKLVGDMVPTSYKVNPRAERGRKKVAMKGTSEKDVDDVIDDSNRKNTYVGHYSDSDRTVIEWMKMLYLGIHPELAQLDNRSVVAKICSKSRVPMLWTSVDSGFRLIGRIRRCQSGSMWEQQLLSDNNIYGQIDAAAAMGSLGRSVNYASCDSPVVKLAVSKIEMLVRRHHVHPVVRARCLYSLVCLHNRDPRIQEAVQQVFSNYLSSFSLNNTGANYWHPSESRFMLDFFKALALLRDRWGSSPQMAVDMLAKVLEGMNGVNYLVHATNIVDCCSYLAIPPCALRHTSEGSSTCLEIRRLWQLLWHLFRLDAIPGSGSCNRMLTAAFLRCLSRQPIMLELCFNKFAQDKDIGFAFDFHTFIPLRQNILRSEQAAFELGQTYHSSHVHIAAIESLLRVLMTSAYIISDEEDMEDDSPHCCMRMLKVDYETQVKRIGQFAGIYEAARCSRRLCERFTEAELKIHTWDAFARVIDELAQLHPVLFIDLEGPYAKQTRDLLYDLLRPCAMSSQTFQVQIYIRIRRAIMLLFGKGFAWEGDVVPNEQLVSQHIDLLTSGLSLPRIAAFRRIHGDGASGGSSDWLQVAVEAIEALKELPQARWFINDPEQSYVGYRSLVGHPMWLTKIANKALSGYYSMPMQFKADMALVFKNAKSVNKADTLPYADALFVEEQFDSLWPAIVRTYQRSVKASIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC14</accession>
    <name>A0A061DC14_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Processing splicing factor 8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0400290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769723.1">
        <property type="nucleotide sequence ID" value="XM_012914269.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DC14"/>
    <dbReference type="GeneID" id="24566078"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400290"/>
    <dbReference type="OMA" id="ANKWNTS"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PRO8NT" evidence="7">
        <location>
            <begin position="62"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PROCN" evidence="8">
        <location>
            <begin position="441"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="RNA recognition motif spliceosomal PrP8" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U5-snRNA-binding" evidence="11">
        <location>
            <begin position="1281"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U6-snRNA-binding" evidence="10">
        <location>
            <begin position="1486"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="domain" description="PRP8" evidence="13">
        <location>
            <begin position="1804"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="domain" description="PROCT" evidence="9">
        <location>
            <begin position="2263"/>
            <end position="2366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2372" mass="274537" checksum="87300C1E15C53BC6" modified="2014-09-03" version="1">MGVPAPPGMAINCGGLPPGYNVGYTHKTEFEILQDKARKWQKLNTRRFTKTSAAPLATYAAPMPPEHLRKVFREHGDMSNRKYRYDKRVYLGALKYVPHAVYKLLENMPMPWEQLRNVRVLYHITGAITFVDEIPWVVDPIFLAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYSENILDVEPLEAIQMQLDPEEDAAVMNWFYDSKPLQYESKMINGPSYRRWFLTVEQMGVLYRLAGQLFSDIQDDNYFYLFNLKAFYTAKALNTAIPGGPKFEPLFRDAQEDEDWNEFNDVSKIIIRQQIRTEYKIAFPYLYCNRPRKVAIAPYHTKLCAYVKQDDPDLPVFYYDPVINPIPAYTIKDGNVREYDSEDWDRSDATDPCSKPNSFVSCSAAETLNDGVENNKNGDISYSSPDAGTNFPRGVVPLLATVPLESDNTSNGVALCWAPHPFNKRSGNCRRAIDLPIVQSWFREHVPASHPVKVRVSYQKLLKGWVLSNLHSRRPKSMKKRKLFKLFRATKFFQTTEMDWVEVGLQVCRQGYNMLNLLIHRKNLTYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDSHAQYRLGNVDAYQLADGLQYIFAHVGQLTGMYRYKYRLMRQVRMCKDLKHLIYYRFNTGSVGKGPGCGFWVCGWRVWCFFLRGIMPLLERWLGNLLARQFEGRVSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIRANKARTILQHLSEAWRCWKANIPWKVPEMPAAIENMILRYVKMKADWWTNASYYNRERIKRGATVDKTVCKKNLGRLTRLWLKSEQERQHGYLKDGPYITGEEAVAIYTTAVHWLESRKFSHIPFPPLNYKHDTKLLILALERLKEPYSTKGRLNQNQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVTIEFMDLYSHLIPVYDIDPLEKITDAYLSQYLWFEGDARGLFPNWIKPADSEPPPLLVYKFCQGINNLTDVWNYEDQHLVLLQSKFDRVYEKIDLTLLNRLLRLIVDHNVADYITAKNNVSICFKDMSHINSFGFIRGLQFGSFVFQYYGLILDLLLLGLTRATEIAGPTSMPNDFLSFTDVETETRHPIRLYCRYIDRIFVLFKFTSTETRDLVQRYLTENPDPNNENVVGYNNKSCWPKDSRMRLMKHDVNLGRATFWEMQARLPRSVTTLEWTDSFVSVYGKDNPNLLFNMCGFEVRIFPKIRWLKSGASQGEACWKLQNERTKELAATAYLRVDADGMSAFENRIRQILMASGSTTFTKIANKWNTALIGMMTYYREAVIHTNELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHILIPQSDLKYSKQTDTGITHFRSGMSHEEDQLIPNLYRYIQTWESEFIESQRVWAEYALKRQEAQAQSRRLTIEDLEDSFDRGIPRINTLFQKDRHTLAYDKGWRVQQDFKQYHIMKANPFWWTHQKHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFATWEGLFWEKASGFEESMKYKRLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESLVMDLCQVLDLELDALEIETVQKETIHPRKSYKMNSSCADILLFAAYKWHVGKPSLLTDADVGEATTSTNKFWIDVQLRWGDYDSHDIERYCRAKFLDYTTDSMSIYPCPTGCLIGVDLAYNMHSGFGYWFPGMKTLCGRAMNKIMKANPAMFVLRERIRKGLQLYSSEPAEPYLSSQNFGELFGSQTIWFVDDTNVYRVTIHKTFEGNLTTKPVNGAIFVFNPKTGQLFLKIIHTSVWAGQKRLSQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPYQSIMKLEKFGDMILRATQPEMVLFNLYDDWLKSISSYTAFSRLILILRAMHVNCDRAKVLLKPSKTTVTLPHHVWPSLTDAEWINCEVALKDLILADYAKRNGVNATSLTQSEIRDIILGMEISPPDIQRQELEENRNDAAAKTVTTRSVNVHGDEIIVTTQSPHEQKVFASKTDWRNRCLAAGLLHRRLEGLSVESVDSEDTVVIPHNLIRKLIMVSDLRTAVAVYLYGKISSVDGEPDQATNDGSRGGGSHVREVTCMVFVPQVGNQYTVDLPKQGPQHEALDGLEPLGWLITRPTDGSVASEVVETHRRLQNDLSWDVASILCTCTFVRGSCAFLAHRLTPDALISKDVSNTSALLTAVQVLISDKYKGFFLVPVDEAWNYNFMGAKHSLHMHYQLQVEVPRPFYDPVHRPLHFIQFAQANESKDFELENPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA2</accession>
    <name>A0A061DCA2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">-Transmembrane emp24 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0401740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769868.1">
        <property type="nucleotide sequence ID" value="XM_012914414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCA2"/>
    <dbReference type="STRING" id="5866.A0A061DCA2"/>
    <dbReference type="GeneID" id="24566223"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401740"/>
    <dbReference type="OMA" id="IIRWSTC"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600263" evidence="8">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="205" mass="23001" checksum="92A953452996C448" modified="2014-09-03" version="1">MTGKLVATAAIVLAAASLIEGTQMIMAANETQCFTTFASRTEKLTGSAESVPDESAVKPMIYKVDGPTSRPTTVPVLVVSDNQFEYDVQETGHYSFCLTNKSYSKNTVIFNYRVETTLNKDLSQLSTVEDANELIAFAEKLLENTHVIVDRTETYSSREQLYSGIIDDMNVRIIRWSTCQLIFLIVICFCQIYYISSFFEVKSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN3</accession>
    <name>A0A061DCN3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor IIIC subunit 5 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767861.1">
        <property type="nucleotide sequence ID" value="XM_012912407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCN3"/>
    <dbReference type="STRING" id="5866.A0A061DCN3"/>
    <dbReference type="GeneID" id="24564216"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208290"/>
    <dbReference type="OMA" id="GPWRGCM"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="1">
        <location>
            <begin position="43"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="307" mass="34790" checksum="E2CBB5CDBF64F904" modified="2014-09-03" version="1">MGKVSSIFTFNQPADFLHIANLPVVTDEEGASNVLNQGYELLPPFFTKTAYIANIFKDTLKNSSSSKKGLKERTSHMLNPVAHFDDAEIPTKPLESTLHASLDRDLIMELKKLFTKRKVWLRTAMDEYLATRFSSWKKKNAFARICYIFAGLSTLTTPNHATQIIDFRDPYYRTISWKTEKQTTGREGSGAQSMPMPLDEIYAEAVKSMPNFNPEVHFLAPPSRPSQLYQLCDIFDAGIQKLINNTSIEMEVNTTDTCSKATGECWPSPIMKNAGWYTQAVMSKIRDMMNVKSLRMRQMQTASSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN4</accession>
    <name>A0A061DCN4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770088.1">
        <property type="nucleotide sequence ID" value="XM_012914634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCN4"/>
    <dbReference type="STRING" id="5866.A0A061DCN4"/>
    <dbReference type="GeneID" id="24566443"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403900"/>
    <dbReference type="OMA" id="AITTECC"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="24004" checksum="4FB37652F5BB41AF" modified="2014-09-03" version="1">MTISKDVLSFANTSYLMEAAQKKCLQELTQTATSEVEESAPQPVHVPRDDLEYWRRERLAAIKRMRNKSRDYLEQGHGSVETMADEKQVINTCNSHKRVICHFYNEEFTRCKILDRHLTTLAAKHLEVKFIRMPAADSPFFAKKLEMQILPTLISVLDGNIKHVFIGFEEFKGDNISVHSLRAALLKRDAITTECCENLDEEDPSEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDV4</accession>
    <name>A0A061DDV4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768791.1">
        <property type="nucleotide sequence ID" value="XM_012913337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDV4"/>
    <dbReference type="GeneID" id="24565146"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305080"/>
    <dbReference type="OMA" id="CPYIYTA"/>
    <dbReference type="OrthoDB" id="364460at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="398" mass="45329" checksum="1D77E8E24EF4E84B" modified="2014-09-03" version="1">MSSATRSPAVPSNGDTSEQGDDTSSATDSQSAPAAPSEPIYYLYGDDERWWEEEETKGGEIPAAEAWEHPPRHQCLLETIHKLNDTHIRSPFLYTRYPHEYKSEAYALYHQPGAQSKKSEHPKEQSSPKQSDDPQRRRVNIELTPVKRPEACTKPRKSLRERLEDGEVVFYEDYVEREIARDYCRLFGRPFSVPRHDWGGGDFFFGEHVPTVTSVPKEVPRQDEDDKLSEKSAESVEDPVKHRQVDALILSDTSLDPAQRQEMLDGKIANLYSALPSGATRQRHPKDRLVSYHHLRTYAYMIDSVTKCPLIHVELQSALQQGWSPERETAKLQPRTRTLQPPKDPYTVTPEQLARANEILAGRRKIKADSSKDVKVMVSRRQAAQKETVQVGGGRYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDX6</accession>
    <name>A0A061DDX6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768851.1">
        <property type="nucleotide sequence ID" value="XM_012913397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDX6"/>
    <dbReference type="GeneID" id="24565206"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305690"/>
    <dbReference type="OMA" id="HYLGYKL"/>
    <dbReference type="OrthoDB" id="364226at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="388" mass="42930" checksum="FA1309DCDD313F7D" modified="2014-09-03" version="1">MPAYASLKRGASGYVGVGSSSPAVSGTDSRRAAALIYVGYTVNGFGYCFFATLVFDSFTWLLDRSEAAGLFRLHGTQRHIVEAISTGVVSFVWTRFLTQRFDGDVFSHVLYWRYRLINTWEMLSRSLGGLSAGILFGLFYMRLYHSGVAELNSSSDGFAVPSFADCPDCKTFSEIIARSLPKAADGLGILRSVVVAHLPTTLASVDLLQRITAALARVAWVLEQFIFEFCFCTAMYLVLSVTLVADHVVDCFALYIVYKRLVSFTANTYLRDIGGSICLDASVSVRRFVADRNTPLLCSRLLANFVAVFAAERFFNPMQRLRHCDFAEIYGNVSDSKKRAMLPNDGVTEYVSAGAVSYSDVGFTPLPDTYLGRCLERFAMRPAKCKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDZ2</accession>
    <name>A0A061DDZ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768901.1">
        <property type="nucleotide sequence ID" value="XM_012913447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDZ2"/>
    <dbReference type="GeneID" id="24565256"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306190"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="8703" checksum="32E3945A02C05B2F" modified="2014-09-03" version="1">MDPPNCFNQVYVEDEVKNLSDVRKSLVASRTNHFVTLEFEGSQITPRDMLRQTPPLECRCVTVKGVTLSTIQIENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE55</accession>
    <name>A0A061DE55_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0404800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770180.1">
        <property type="nucleotide sequence ID" value="XM_012914726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE55"/>
    <dbReference type="STRING" id="5866.A0A061DE55"/>
    <dbReference type="GeneID" id="24566535"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404800"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="6">
        <location>
            <begin position="134"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="30929" checksum="7161DC5024762D28" modified="2014-09-03" version="1">MLELKLNHAVVLRRIFDCIRDIISDGNVDFDATGMSLQALDGNHVALIHLKLHESGFSRYRCDRPRALGINLNSVTKAFKSCSNHDSVLIQSEEEKDIISFIFENNVDERVMSFSLKLMSIEQDALSIPENMEGYDAEITLGSKEFANICKQMNEFSDTIKVDVSVNSVSFATRGDLGYGEIVLKNRPPTNEADCGVSVKVRRPIKQGYATKYLLMFSKSSCLSDVVTLGLCQNRPIEVRYDVKDIVGDNDSPHAQVLGELRFYLAPKCDDAMEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE82</accession>
    <name>A0A061DE82_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769096.1">
        <property type="nucleotide sequence ID" value="XM_012913642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE82"/>
    <dbReference type="GeneID" id="24565451"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308140"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="105" mass="11308" checksum="2790413E7DB49851" modified="2014-09-03" version="1">MHKPQAVNHENDDEEDEGDGGDDDLGDQWDLDYNVCANKLSRSAVERDAEGYLADEEIADVAAYREAEDAQVEQDDGDDDGNDDGGDGLGVRGGKCGGFFSMFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DED7</accession>
    <name>A0A061DED7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769286.1">
        <property type="nucleotide sequence ID" value="XM_012913832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DED7"/>
    <dbReference type="GeneID" id="24565641"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310030"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="95" mass="10314" checksum="C0BC07FA5CA2AFC9" modified="2014-09-03" version="1">MGIVYRQLAQGVRGIRFIVNLAPRKMCFCSGGGGNCKGEVKCIGIHIAIAFAGFIGFSALLVLVLYIMGRQYDVSLGTIFGQIRDGFRGYKPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEP2</accession>
    <name>A0A061DEP2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769811.1">
        <property type="nucleotide sequence ID" value="XM_012914357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEP2"/>
    <dbReference type="GeneID" id="24566166"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401170"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="580" mass="64411" checksum="64A7A2E64E722C93" modified="2014-09-03" version="1">MEFSVISSSHLQPNMITCGTTYGDLYVLDAFKPSYHRIDMAMVGRFAAYTALEGLESQQDQPGMTSAASYRRGHHAAEQITVERYSKLFRSGVRCVEFHPRLPSLSAVGLDDGSVHLLFVEGENLVIKKTLRLFTFNHPVDQLEWLLVKGDKTDGKPNLRPTSFVDRIWRILARASYHSLLIGRASRHVKVVRVERNPRVFNFPSVVKAPRGVGKDEPRQGVQQPRTPADRKGGKQKLDKSEAHGESGNGETEGEVASVSVIRWPQPGYFEEELEYPTLTNFCLVQEALGVVMHHENGVYMHIYTPLEVESNLKFAEFEKRIRLPIKGVPTAIQISPKQYNQMRRYLGTNNAHMFTLNGEKCLNALGEFIAIASDDGCVHVTSILHIYNRARAAVTAAAGKTNIASATNAGSTEDTANAAADASNNDHVGRRSSLDERNEAEVTADDRDGHSAPTNCGDAARYFDVEMASLNVGCVVKCLRWGLLWNDYVRQPHLVAPDQCCCSDDIRFLLAAHTEEHVEVLQLAKNGGILSLESSEHIGVQGSAVHWVEDTIPNDMTLMIATNSGLERFTWERARRTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DER4</accession>
    <name>A0A061DER4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">-Protein C20orf11 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769921.1">
        <property type="nucleotide sequence ID" value="XM_012914467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DER4"/>
    <dbReference type="STRING" id="5866.A0A061DER4"/>
    <dbReference type="GeneID" id="24566276"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402250"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="260" mass="29890" checksum="B253CC3833644D5F" modified="2014-09-03" version="1">MAGSSSMSAHYQSSSDEGTAQEPIHSAYRHFRYVRDRESWLADLVDIHVDDVYLQKIVMNYLVVNMCEESYSRFIEETGYTGPDLSHTIASRRRIRDAILECRARDALDLINGVDPKILQKNVHILFNLLSCDLIDIIKTGDSKKAVEYARRMLAPCVQKDRSLIEKLEEILGLIAFGNMEDVDPLDLKHKIYRPEDTAKLVDIALMKHFRQDTRIMLVSLAKEAAWLQGKLSDQEVWKHIRYRDLGRAGIAFTHDVNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET4</accession>
    <name>A0A061DET4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0403230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770021.1">
        <property type="nucleotide sequence ID" value="XM_012914567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DET4"/>
    <dbReference type="STRING" id="5866.A0A061DET4"/>
    <dbReference type="GeneID" id="24566376"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403230"/>
    <dbReference type="OMA" id="ENFERCT"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="49"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="292"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="489"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="435"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="670" mass="75388" checksum="FD43919C6F16624E" modified="2014-09-03" version="1">MASMPKPAALRPPLVFGWNLPNPGTSDLLRVIKIIESVGISFVSLNLNSAEEGQQNDNFVPLCGSDLVLTYNYWSQRIVARIDSVGGAFMSYMEWSAYLGLRAVCIHCEPIFQQATTLAESHELLANLAQRLKAFLHSPNMPTVCLSFAANDVSWGYWNAIHEMTNYSPQLKVAIVIDDDDAGRLARWVAEPLTAVILRESSFVRVGETVQLKPALVPHLHFLLQYDVKVMLSGMFNFEPLRKASELRSADSLELIAIRDLDTPPMPGGIGVREAITAVRKAYAAMPPLTEAEQFKEGFWDMLQEPLQPVRDNLETATYENFERCTRKYAQYEAAVSLWLKDFMAGALPGQAAPGEGDNGNHEGHNGVRRPVIYIVGAGRGPLVDCSLRALAENNVTEFSIYALEKNPATVFTLKHKIATNAIKGWDKVKLIFQDMRTLKPSEPADLVLSELLGSFGDNELAPECLDGVQNAFQTHFPGHRVTFMPCTYVSYAEPIYAPKVWASLNLTQIERPFQHPYTVALHKFCKVAEQPKPCFKFEHPNKQMKGCCSDTDDVQALCYMNNEHNNRYSCMSFKSTLECFIHGFAGYFECTLYKDVKISTVPGVMDDQISWFPMYFPITAPIYVKEGQLVMLHVWRKHDKRRMWYEWALTLPHVTGVHNSNGTCHSILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEV3</accession>
    <name>A0A061DEV3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770116.1">
        <property type="nucleotide sequence ID" value="XM_012914662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEV3"/>
    <dbReference type="GeneID" id="24566471"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404180"/>
    <dbReference type="OMA" id="FANHLPI"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="194" mass="21415" checksum="C0D0BC3E757C6D77" modified="2014-09-03" version="1">MPIFYRIPQAFRRSSVVRAAFTNCLRGNFEPKAFTGCAALRAMSSMCAPVSESPVYRDMIERAKTAYGGSSEVDSAMSDMLSSRRLVLFMEGSLDHPKSLCAGNLSRIFSGLQVTGLYTVDLLREPEILGFLCTHLGESVRNVLFKDGAPALDYDQIVELFQKGTLLQALEVTPKPSEPGVHKRFRGLLPIANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZN3</accession>
    <name>A0A061CZN3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766049.1">
        <property type="nucleotide sequence ID" value="XM_012910595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZN3"/>
    <dbReference type="GeneID" id="24562404"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101920"/>
    <dbReference type="OrthoDB" id="10322329at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28797" checksum="992708E5BA627AFB" modified="2014-09-03" version="1">MVYKSLTEVPHNLKEGIDWLVALRGDDCRSHMESIAAALYDLLADKPIGLTKVPALEEVKVITKEFMERKHINNQEFVQTLLRRFNGPMDKTNIHFKRFMHKNDGDYDNIIKLKRLSPESMARFLGLVVYGCDKFLKHMKIPDEYKSAYSSEATWEASCAEDPEACAVVLVGIAPMLYTGLRSLKDASDEANKDPSNGETRTRLRKVLRAVGYRRSKRRANISVSFMSKALSDVDKDVLDILYDFAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D001</accession>
    <name>A0A061D001_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0103180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766184.1">
        <property type="nucleotide sequence ID" value="XM_012910730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D001"/>
    <dbReference type="STRING" id="5866.A0A061D001"/>
    <dbReference type="GeneID" id="24562539"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103180"/>
    <dbReference type="OMA" id="GREMFYF"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="344" mass="38753" checksum="20F5C74CD43A43B6" modified="2014-09-03" version="1">MAGAGSKQDRAQQKALEKQKQKIAEDKTFGLKNKNKSKSVQKFIKSVQQQVTGKQTSNDKLLTEQNKAKAEKQKLSQQQTLLASLFKGTENIKHVVVDGNKPLYDPKQSRDDQKIDLYSDPRLQKSEDGDDMSTWDLNMLEKVVSEKHAGDSCTTDIICKHFLTAVETKKYGWFWTCPNGGDKCKYRHCLPPGFVLKSDVPKEVEDEDETLEERIERQVLSWAPHVTSVQRAELPPGGEMVTAESLARWRASREQGRLDELNETMQKGGQVHLTGKDLFTFNPSLFMDDDSAAADLDYEDEEDIDAIIRANEAAITTGNVLPNGEQYRRGEDELDTVDISNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0A1</accession>
    <name>A0A061D0A1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0105650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766442.1">
        <property type="nucleotide sequence ID" value="XM_012910988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0A1"/>
    <dbReference type="STRING" id="5866.A0A061D0A1"/>
    <dbReference type="GeneID" id="24562797"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105650"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="258" mass="29590" checksum="CEFFD7FB37605AA1" modified="2014-09-03" version="1">MGTHIKFRLCRTAIASVGCMFNASFTSRLYTTVRTLGRAYENPRFITSNVFYCNKQFRQFSSKGSESPKESQFENEEPSQTEQTSHENTADEDSPVNLEEQVEELQSKLEEVTGKLKELQLKYRISLDNCEQIEKIAAKKLNNAKLYAITHFAKDMLDVADAFELAFKSLGTQKETGLNAEFIEGIRLTEQQLHKTFEKHGIKRFESLEQKFNPEVHEAVFEIPDKSVDRNTILQVVFNGYMINDRVLRAAKVGVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D186</accession>
    <name>A0A061D186_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766048.1">
        <property type="nucleotide sequence ID" value="XM_012910594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D186"/>
    <dbReference type="GeneID" id="24562403"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101910"/>
    <dbReference type="OMA" id="SDPNQLC"/>
    <dbReference type="OrthoDB" id="365411at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="530"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="596" mass="67223" checksum="E69084D6F83CE621" modified="2014-09-03" version="1">MRLSRVFRHLCVPEVARLRALVRDGGGDAQTLYALFQKHNEQLSPTENLLAAVHIEKLSAGQDGSEEVASRMANVRATALANIRGKLYAFTDPGDLCNLIRAALAHGVASRGLIYDFYGRLERLLPHVRGEALTQACHTLVELHKAGHRVVPICSKIFAYIAARGSESELTLPNSVALVHCMAETDMRHEALGSRVGRSLRLLLTRGGKITTEEASALLQAYKEDMFDSVFIRRRLMEAALTGDAIPMQVLVNCLSTGVFSSSNANRIDDLVLTGLSTCDVKTIIRLLLGYGNLRYRPAKVISELTRTLESVMFNLDSFDDVARCIHSLFLLDEHNPVVMEFATNFIKGLDVPLGVENIECICDALLAFCHFNMNDPEVYQRLLREVMRLDCSIPSACLVRLQLVALYIWKLTPQIFDSLGETSQQYLLEVAHRVTMEPETVRKCDLQESVGKTATFVSHVLYKQVEFDYIQPSKRRRFRLVRISSISCARSVKRNWRRPGNGIPEDCAHVDQGKNACLVGCNYLRPLASIILADDIVQFYRHSRERTAKSQIQLGLLQRLGFRCICVPYWKWEELGGWHQKREYLSELFVEHKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1I4</accession>
    <name>A0A061D1I4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0108010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766689.1">
        <property type="nucleotide sequence ID" value="XM_012911235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1I4"/>
    <dbReference type="GeneID" id="24563044"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108010"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595877" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="818"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="947" mass="107122" checksum="E8E709C1F342FB61" modified="2014-09-03" version="1">MKYLLVFCAIIIQTIAYSRAAICDFNDPDSTLRYYPLITCSTDVNHFAYRPIICPREVNGIEYVLHPQPTPDEHAHLTTYVSRNGALRSVPLYEVVRSEAENALFRIESFPSQTELHFDMSDGQMFVVTDDRLVFICGPRDLVMSDTLKEELDLLNVTRQKKAFAWNHGDTLTDEIGKLGSGLGVAYVYRSLSHIPLQGCGSRPSPLFAPDNVVSEDGFTGTRSCVADYMSNVRIGFVCEGRIEPSDCFKSLLDENGKRMEIATQLHMYQHFDVNKPWVIAQYFDGLALPSFNGECRCIDPETGHVKARIEIRSKKEYVCDITSKVFRNHTEVIRGPWCSVLLHPGSTLTIRFPIEHVGDSKPVTALRNPPRYLFKTEFRPQNLDFLQQNINTYQASIYNVVSYSGALAGDALELDISQIPQGVVTLKYHADKPLTLKRRVNSFLFHWLLKPTENYNLGPIRAIINVSFAFTHDYRIVGCDRAVTSLFDPHISLKYCSVEYMGNGIGEVYQCTYNSESSYWEAGIRCQPDEELLPGNCASELYDLHSNEVSPLPDSVQLSNNFTTKGFQVFALDLDKEAVSYACICVDRRGYEKSRLTLESHYDDYHYYRVRHMRQRNMVLPYMLLPWREVGLSSEGFTSRDRLMLYDVTPSSITVYAGASLRLYCTGNDEILIHDEYVGNYSDVQTSWLPKQSKFFHYIIRNTPQGNELVSVPHSDFIGSNPGDFKVALEASTEDINELKIELRKGAVLVSKNVAYKKYVPITFVCGKTPEQSEVTEIASSAISSDGSLQPMNNLMGLSIGYTWHIVQVVVETTDPYMQGCGVTYASDELFKPETPKLYDANGRQIGCKIDIQSAKEAAFYCPAPYVLDPPDCFNQFYVDGEVKNRSDISKLLASFRTNHFVTLKFGNYGTGREETLRQTPPLECHCVTVKGATLSTIQIENYYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1J4</accession>
    <name>A0A061D1J4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0108110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766699.1">
        <property type="nucleotide sequence ID" value="XM_012911245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1J4"/>
    <dbReference type="STRING" id="5866.A0A061D1J4"/>
    <dbReference type="GeneID" id="24563054"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108110"/>
    <dbReference type="OMA" id="DKCPGKG"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="178"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="359" mass="41569" checksum="E5102660C346A1B0" modified="2014-09-03" version="1">MFLLSLERSIIQHVSRLNSLYSGAGSSGLLKWRGRGIGVSRSAASSCSAVAPPRDLVVVEDGRLRGVHYRNLFGCDESDSSGEARPFTPHPFNRRFAFSKRPLFPIEPRNLRIYGLKRHKKRGRGKKSSARGYRFKRQKHRGGKPNSRTFEGGQTPLFRRLPKWPEAWLSRQRKTFDPLNLAKLRYFIERGRLDTRFPITQRHLFDSKCVKVKRGVQLFNVNDYPFPYKIDIEVAGSDQSSIDAIKRVGGSVTIVYYDRVNLRAHLKPYKFEVLPKTARPSIERVHYLEKMRARGCNVVYIKPMWLIKEEQAITAEMAELEAETLTSSDLDPDETPSKREERLVKLYRERLLRFGRPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1S9</accession>
    <name>A0A061D1S9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0103970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766273.1">
        <property type="nucleotide sequence ID" value="XM_012910819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1S9"/>
    <dbReference type="STRING" id="5866.A0A061D1S9"/>
    <dbReference type="GeneID" id="24562628"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103970"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="220" mass="25100" checksum="375F2DEE853243AD" modified="2014-09-03" version="1">MSEALAVKVSDEMSQKMDEKPMFVIVGPSGVGKTTLYKMLLKEFEHLFELSISYTTRPIRKNETNGIHYHFVTEEAFNEMKDADEFLECTSYVGNQYGTAVREIKRIQGSNKVPLLEIEIDGFGKVRRKGLPLRSVFVTTSDVESLRNRLISRGGHNITDMDKRLKRAMEEMKEANDASFDVILVNDDLNVAYAQLRDHVLKWYGLPNTDKKQDEPSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D225</accession>
    <name>A0A061D225_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0104810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766358.1">
        <property type="nucleotide sequence ID" value="XM_012910904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D225"/>
    <dbReference type="STRING" id="5866.A0A061D225"/>
    <dbReference type="GeneID" id="24562713"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104810"/>
    <dbReference type="OMA" id="DRICVEM"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="47"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="254"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="734" mass="81538" checksum="46E1239787B46192" modified="2014-09-03" version="1">MENRKPAEDEVELTSETFEDLDIDYRAKKVLKDKGYTYLTHVQSRVLPLALAGKNLIIQSPTGSGKTLCFLLPAVKLLFDDGYNGNFPSDVSMLGCICLASTRELATQSAIQMNDLARPLGLKSGCCIGGIRDKYDKSNARRLQILTGTPGRVLSLLSNDALSYTSNVKLLVLDEADRLLDSGFRNDILDIVSYLPPSTQILLFSATIRSSLQDLCDYLLRGKEYEYVCLGSDAALLSASKLRQDYIVVPMSLKLPALFHLLSKHQQKRFIVFLATCKQVRFVYETFKRLIPAVPMTEWHGKQSQLKRNEQFTRFAAKQNYGCIFTTDVGARGVDFPAVDYVVQLDIPDSVSTYTHRVGRTGRLTVEGTRSFGCAFTIFCENETPLVDELKAAGVKLHNFTKLLWPFLLRKENYVLQKLQSMLAKEAWLKEAAQRAVTAYMRYLTTRKSVTLSGHALVEAVKQMALASGLPTAPHIEVEDDSPTEKVSKLSKLKEKIRAKKRENAAKERLSAGDGHVSSEPASSSGPRADVNRSSQKVAQHKAAPSETDSDSDTSEAGSNESSGDDSPVDSDGSDVDELSEDGSPVAGSDGQSGSGSDAADNTGELLKRGSDERVEEDLRLYEERRAAEDREDIRLKSALASTRKKLRLNRHGVAKIRGVETIRQSGQKHTMFDADSDEEEGTRYEAAPPALDDMLREKETYIKSLSERLKAAKKDDHEWEARRRAERRAKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2B6</accession>
    <name>A0A061D2B6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766934.1">
        <property type="nucleotide sequence ID" value="XM_012911480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2B6"/>
    <dbReference type="GeneID" id="24563289"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110460"/>
    <dbReference type="OrthoDB" id="366306at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="275" mass="30871" checksum="13FDE05483C82571" modified="2014-09-03" version="1">MQQRVVYSSTDYRTPYHHDDSHFTYGNRQTTGLRTDITTASSAPASPAHAFGRLAYEKAAISGTALVPIDSSSAALARRPSTVTEAYHEVKGSKQRERLNSTFDDCIPTENHLQSLSRQLTATTRPIDDYVEAKPVEAVDEEPEYPHLALDLSVLTQTKHKNDHNTKPKHVERRAAAQQKEPQTEAKLIVGKPRHPYAVQFNDPVEKELGRWHNSHVSTIKWTRIKRGVYTADDQQVTLVKLNGGLYVKGTNGKKKQEHIPIDKFAQRLQKTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2C9</accession>
    <name>A0A061D2C9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0110560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766944.1">
        <property type="nucleotide sequence ID" value="XM_012911490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2C9"/>
    <dbReference type="GeneID" id="24563299"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110560"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57606" checksum="72539FBB09DE46BD" modified="2014-09-03" version="1">MSEPHASSPAVTTSEPSGKEAKKQTEDYGTFGQVLYHVVSFTEGYEQQVLYLCMRLFESTMGFTKQQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSSTSRYSSILFLRFLHGAAFGCIYPVQQKIISDKDDEESSTSSSTFTRLHALNCIGLGIAIIFAMQTPKELISPYDSINDFINQISGAFKAVFNSWSAFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDMKVGIAILVTTIGGAAGTAAGGIVIEKITSTHKEFGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIEDKYQASASAIIQCISGISVSVSFVEIFAYVSEKLHGYAPSTQAIDDMEKGLKDNNTEALRKSTMYMIVIGSLLNIACYGALFGTYKTDKEKIVPENKKEWKIREERRQEKLKQEKSVSDKTKQEEAITEFPEEPKETAITVIPGDGGAEASMEVERPEERGRSDDYLTPEQRIIFLRSGGTRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2D6</accession>
    <name>A0A061D2D6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0105660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766443.1">
        <property type="nucleotide sequence ID" value="XM_012910989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2D6"/>
    <dbReference type="STRING" id="5866.A0A061D2D6"/>
    <dbReference type="GeneID" id="24562798"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105660"/>
    <dbReference type="OMA" id="RRTDNTI"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="249" mass="28412" checksum="C0016C7937222242" modified="2014-09-03" version="1">MCNEIFKYFVRISCRPNKVDNLEYCLRNLVALDATPVSLQSCEATTLLDISRDNAQLLINRIFSLPRIATPDGVFASLPKEDVITMPRMYPLPKPKPKTRWQLFAEARGIRKHKRSRMVFDKTVNDWVPRWGYKSIKKGVAANPPIVEVGDSDYAQSVDPFEEAKRSKNVQKTRQKLRELRNKAEANALSKTQSALQRAKLSTRSYGEFDKKTENVGAKPRIKRKVATVSLVEEKKSYLASIKKLNIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2V8</accession>
    <name>A0A061D2V8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G patch domain-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766603.1">
        <property type="nucleotide sequence ID" value="XM_012911149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2V8"/>
    <dbReference type="STRING" id="5866.A0A061D2V8"/>
    <dbReference type="GeneID" id="24562958"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107260"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="309" mass="33407" checksum="E4E84E527DBD03A0" modified="2014-09-03" version="1">MSKAFRESVRNSISSVGSAVKSKFGAAILSKYGWKEGEGLGKNRDGIVDPVKLRAAKHNEGLGRKDSDQWHNWWDELYNEMASKSTKVTSVTSTVTDKGSNTENGESDYSHSGDDESAVDASSSELSSDGETSSDISSESSSSDESNRSDGAQLQHHSYNSDIYRKHKMIRVRQDVETVGGGDGGDAVANRRSDSDQEYAVEANEGGHSSDSSTSDSGVCSRTRSSGRRITPVDVLSGSDSEAPSAPKISSIGNGNAENVKRQPRHKRLIASHDNNAADSTAVAEKPSRHGRETDERKKSHRRKRQKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2X3</accession>
    <name>A0A061D2X3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0107365</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766623.1">
        <property type="nucleotide sequence ID" value="XM_012911169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2X3"/>
    <dbReference type="STRING" id="5866.A0A061D2X3"/>
    <dbReference type="GeneID" id="24562978"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107365"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107365"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27891" checksum="B2E8403704C2F829" modified="2014-09-03" version="1">MARRILVFDMDGTLTLPVQPITEDMKEVLLRCKNRGYDIAVASGSNYISIRKQIGKDFVNDFNFIFSENGTQVHQRGELVHSLDIRDVLPEKVLKELVEFSLIYIAKLDIPVKRGTFIEFRKSLINLCPVGRNCSNQERQEFAALDKERDIRGQFIEELKKRFGSGDLALRFVAGGQISIDVFPKPWTKALCISHLKDYEEIHFFGDNTHEGGNDYEICNHPDVIGHTVKNYKDLIAQLNDMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3C4</accession>
    <name>A0A061D3C4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767284.1">
        <property type="nucleotide sequence ID" value="XM_012911830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3C4"/>
    <dbReference type="GeneID" id="24563639"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202550"/>
    <dbReference type="OrthoDB" id="366608at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="36139" checksum="ABEF107B1E0816FA" modified="2014-09-03" version="1">MVYTSLTYAPRNFREGIDWLVALKRNGFENNLKAISDAVYNFLADKPVGSDKLPIYQYVTLITKEFLEQEELKDRRVVETMLAKFNEPKDQKSDFFVKFFKGISELGGRKFVKHWGINGENIAEKLSKSVDVCETFLKSIQVPGQYKSAYSSKATWEASCSDNPQECAAVFVGIAPMLYAGLTSLKDATAAEVVKSAPDRAKADVENLLNALRYVGPACRASMSPSDVSNALRDFDYDILGTLADLSEFWMYHGLDSAGVAEALKYYHSKYGSYPITGGDNGVNMGLVNAWNSKLAKKPAKTDNALGSDNTYYPGMPTVANLNAASPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3E4</accession>
    <name>A0A061D3E4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766788.1">
        <property type="nucleotide sequence ID" value="XM_012911334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3E4"/>
    <dbReference type="GeneID" id="24563143"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109000"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="94" mass="10197" checksum="10CC20E5471EEBA1" modified="2014-09-03" version="1">MLATNTTELLHPLSITSDCPTSVPSRPTHSSEADLDSRPPSFAMDQHLAISFILEIEYTITSVFMPHFINYPNGSVPCVLGTVVGVNHSSILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Y4</accession>
    <name>A0A061D3Y4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0205940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767622.1">
        <property type="nucleotide sequence ID" value="XM_012912168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Y4"/>
    <dbReference type="STRING" id="5866.A0A061D3Y4"/>
    <dbReference type="GeneID" id="24563977"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205940"/>
    <dbReference type="OMA" id="RYEDHFE"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="659" mass="73301" checksum="9E61C88F4F8FF4C1" modified="2014-09-03" version="1">MASSALNYASQLRRNDNKGPCGGAQLFDTPAEVSRKFKKLSTLLSDSKYTLLHTGAGISTAAGIPDFRGPSGVWTVMSLQNGGEGKRRKMTDGDCTAKNTGDVAVEYGHKKLEPVEFSQAMPSEAHLAILALLRAGHVQAVITQNIDGLHAISGMRFSECSELHGNVFIERCISCGRRFLRPYVAPTISFKPTGNHCGICHFPPCGVLTDVVLDWFDRYEDHFEKRAISYAEEADLHLALGSSLHVEPACHYASSEHYRKEDAPLVIVNYQKTRLHGEADVVLHCDVNKICTRLLKSLNVALPKFLRHFNMVALHYRFGGHNKLLLRFPCIISIFVNDEYASLSGVSHRCIDRVQGLHEFTFTGDFEAILKLWFDAELVLRARFSPDCSFSGLVWQLCLAATDGVLSHRKNTQIAHEFDDAGGEDPISVARLTLSYNAAMIAKSDACRVIAKLCSEDNTIPGFNARAIPESICRLLTCFTWLFTSGDGPFAALAEIKEDVDCLEEFEPIDHLDLLPEAMRVCVRLALQRQLGTVCKNQFCIDIKALNAARNEPYTLDVYFATSEIRLLCSPEHEFGELLDAISGEMRMCLPRKIRPIALCRASSFNPLNELFLTVLRSSMEAVMKRQSTTAADVKLIKAVQTEFPVWVACYISCLFECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D407</accession>
    <name>A0A061D407_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767657.1">
        <property type="nucleotide sequence ID" value="XM_012912203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D407"/>
    <dbReference type="GeneID" id="24564012"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206290"/>
    <dbReference type="OMA" id="WEANLAI"/>
    <dbReference type="OrthoDB" id="365463at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="462" mass="53186" checksum="3906825A748179E2" modified="2014-09-03" version="1">MEGREDDNHDWESFLWLAEVDWFCCLNRHIVSDWPPVYVVAFYFILANLHDMHLTQIREYALVKSPVFSSFFSSPLTGSVGEHHVDGEPQGPENEHFNSALAKESGIACLLDSQNHILNATQKQIITAMLANANDVELPKRLKFHIYVGREDGRSHIVMCSCCAYQLANVFVKILENVDRYRRNPEPRIARRSKMSSMVSRIVQQIPPLEYEQRMSVLPPSQSEVWDAKLLFTAGTIHHRSPKVKYRRIIVSTAAMLLYVLMPHAYAMTHLRRIIRSADHDSLIALSSIIDGLLLSFPKESDVWSIKLYLVREFLKRLKMKGADLMHGVEKLLGSDCMGVEGLLLKITKKTKMNGRLAWFVRNLHHNVRTMAARNLPVKVKSRVMEQMEQYFIRLCSTLLVADEGYQGIFYIYYNLVRDNPKKLRTLRAICERADRNESWEANVEILNKGAERNALSAQRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4B0</accession>
    <name>A0A061D4B0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767762.1">
        <property type="nucleotide sequence ID" value="XM_012912308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4B0"/>
    <dbReference type="GeneID" id="24564117"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207320"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="138" mass="15564" checksum="7F0822FFEA16A43F" modified="2014-09-03" version="1">MRPSPTSLRMLKRELAMAISFPSLGSSHTRPLPHFSTDAAKRFCNLRFWSTDEAGEKCNTYHPGAKPLRVPMSDKIKPANDVNWVAANRKQCTSAGDGLRRHGLLGPPRSREYSHTNAKRTYFVHLALLLIRQLPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4D5</accession>
    <name>A0A061D4D5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767629.1">
        <property type="nucleotide sequence ID" value="XM_012912175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4D5"/>
    <dbReference type="GeneID" id="24563984"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206010"/>
    <dbReference type="OMA" id="ITYAPMA"/>
    <dbReference type="OrthoDB" id="365822at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595958" evidence="2">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="29399" checksum="3103C7E47B272226" modified="2014-09-03" version="1">MQHSYIISIHTTVLLMVRYTYSLLSTEPATVERLNFVDYKYSPNFTRKQDAAIHEIASSFIDLLESDGFDIMSQKDLMTLASFLETITGENKVVQRSQNGFLNMLKKGGRTLFEAGKNFAQKHAKGAVGDAVKIVFMTLLKKGLPVFEKTYENAMQKIPIELRITYAPMAYNLWTELFKRFKIKMPAGYNVERFICKAMSKEQCDDIIKRVQSKQEDEEEGQLRGAKRSISRDGEYDDEYDENDPSEDDSDDLDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4I6</accession>
    <name>A0A061D4I6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767148.1">
        <property type="nucleotide sequence ID" value="XM_012911694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4I6"/>
    <dbReference type="GeneID" id="24563503"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201190"/>
    <dbReference type="OMA" id="CKSHEEY"/>
    <dbReference type="OrthoDB" id="365419at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="240" mass="27347" checksum="8921575D1A0EFE38" modified="2014-09-03" version="1">MAPFRSLARLSNIAKVSQYVDKVADLGRKNLLFRVDFKHLYSIWQLCKSHEEYKLGLIAVNHFYNFGRQLSPEGVNKLFVFSMRCGELEESLKLLEGARDWLPKPPDIDLVYGLMASFVTKRDYLSVKRVFKAIRSNWQMRLTAKAYRLCIEAMLCSDENPLEEALMVYCDSAVMGIALPSEVHALLLNCLHRKIALEPAKAAFYETSALSVRNRLGEECMNEGGYKISRATSPKITLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4W0</accession>
    <name>A0A061D4W0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767268.1">
        <property type="nucleotide sequence ID" value="XM_012911814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4W0"/>
    <dbReference type="GeneID" id="24563623"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202390"/>
    <dbReference type="OMA" id="PLYVGIN"/>
    <dbReference type="OrthoDB" id="360892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="473" mass="53489" checksum="C89CDE92412BF0AB" modified="2014-09-03" version="1">MDELGYEWYTGFKTPKAVGQTVEEALELFRQETDQAPHQPEVTSNAHKKPALSSIEFSGMAVEVSHEDQMGIIDLANKGIEKWLPVCVNHAAKSQPNSPCNGGEAEKNDHDDCEVSTIKLQSSHHVTLFYYSTKDARPELEDPRTKAVFEQMHDLSPYLRELRCALTPYEFAIALLYRHFYGLSMPGEDGQHNSGHESSRDSSKYVPITLRHVVFVPGVLMCATAQLHRDLVALPSPDGTFGPYCSYPHGNVGTMEELTKRCWDDGAVMLEENHCTHVTLGVTKQYKPVVSNNICDGIRRYLDFLKNHEDADAGDKLWRIKRVNEDDSVDEARPEELLKILEVYGSRPSEFKHAKREFVQLAPHAARRDEAGLAHAAGEAVFDLALPPKDECAEKQIQRYRRTVCFIADGGKWIYIRNLPVRRNLQGPDDETQGTWLVDSYISKLDKAVTGEIRFYKREGHEPKPRPTQSKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Z5</accession>
    <name>A0A061D4Z5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767947.1">
        <property type="nucleotide sequence ID" value="XM_012912493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Z5"/>
    <dbReference type="STRING" id="5866.A0A061D4Z5"/>
    <dbReference type="GeneID" id="24564302"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209150"/>
    <dbReference type="OMA" id="GAHEQET"/>
    <dbReference type="OrthoDB" id="365107at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="27494" checksum="C0F21DFEBA88F147" modified="2014-09-03" version="1">MCFARNGADTPSEDLQSHTAGHVPLNPVESGTFQTIYDDTNGAHEQETRDGSAGSWLQRKIDKAKGIPQSLPMYKSYIEHEIISKDPNVVRGRSSRPRLNRRTRRLLTVLFCIFVAVCAIYGSNRLINWVEDRRHSRSDDATMREVEVLRLKQTMEAMRIEMNKLKEAAYANSVAINGITNGVFRLPGSDDAAAKKMKFGKGNSPIIQGPAAQNFDTRHFANAMGVQGSEAAPEVDLNPIKHEADIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Z9</accession>
    <name>A0A061D4Z9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0207970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767829.1">
        <property type="nucleotide sequence ID" value="XM_012912375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Z9"/>
    <dbReference type="STRING" id="5866.A0A061D4Z9"/>
    <dbReference type="GeneID" id="24564184"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207970"/>
    <dbReference type="OMA" id="VLIMHPG"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF6">
        <property type="entry name" value="ASPARTATE CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="10">
        <location>
            <begin position="65"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="9">
        <location>
            <begin position="221"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="381" mass="42520" checksum="0C66A5F6587B6A05" modified="2014-09-03" version="1">MSRTNAGIAGVTGVGVFGAAVLYASTQYPSFRRQLVRLGICDADPLADTLEPLLRWVAMGMRRIDIVSVDDLSNRQLTCIMELAGYFKEKVSQKQSCELLQNKIMVTLFHEASTRTRCSFEAAMLRLGGKVVSVTDPTTSSAAKGETIEDSVRVLSSYADVLVLRHPEKGCMERVRSHVKVPLINAGDGSGEHPSQALLDLYTISTFFPILQRNKSHTPFTICFVGDLKNGRAAHSLAKLLSRFNVVMRYVAPPQLQMPTQIQREVENNFAKYEIPDLPFPRQTSFSDIEDGCEGTDVIYVTRLQKERMNSEDAMKLRGSYSVQKSLIAKLPPHVKIMHPLPRVDELPRDIDADGRAVYFEQAENGLYVRMAMLYLILNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D570</accession>
    <name>A0A061D570_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768002.1">
        <property type="nucleotide sequence ID" value="XM_012912548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D570"/>
    <dbReference type="GeneID" id="24564357"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209690"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="58" mass="6118" checksum="2A1FC08F6E0907A4" modified="2014-09-03" version="1">MLGNKNITKPLRSLGKSDRIERSVVSPPSSVSSLESNTSLGSVLPIILLPLSGRCGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5E1</accession>
    <name>A0A061D5E1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767438.1">
        <property type="nucleotide sequence ID" value="XM_012911984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5E1"/>
    <dbReference type="GeneID" id="24563793"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204100"/>
    <dbReference type="OMA" id="YIANRLC"/>
    <dbReference type="OrthoDB" id="364816at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="408" mass="45672" checksum="D22ED8F2641AC42D" modified="2014-09-03" version="1">MAGVELLYKPSNMSVLDLGSNLANDLRPSDMAKKTDRKHQNGSLGKPSSSHQSPSRWSPRRSSDVIYSRIDESVHKAKSVLRAMRVPDVDIEGARKEYIQKVGRDYSTVGLTSYILAQKDAKEFRERCFHILSWKPKASQGDGPFDKSEEPFFGDRKTHAGKARTPDEILLGSLGKNNLEPNPENADGDYYSPIRSNSNFAYNSNSPFAGQAQWSEHTKSPFSDVQPSENGLSIGHMTESAIYDVDPLSAKRAVGVHSPMADSSITSTPEKVSEDSQKKRLQVVEELLEEHKDIIPRDLDVKTLGYAEKRRLLKQLGFGDDYIANRLCGRCTTSSKRKKLKLTPLEAFSMYDRQDINESMQVHKDLSAEFSRYVKSTEPRVVVAKTAGSTDDAYNNLKSRLQSSYMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5J9</accession>
    <name>A0A061D5J9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768187.1">
        <property type="nucleotide sequence ID" value="XM_012912733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5J9"/>
    <dbReference type="GeneID" id="24564542"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211460"/>
    <dbReference type="OrthoDB" id="10309716at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="198" mass="22402" checksum="08F8A0682FB0BD9E" modified="2014-09-03" version="1">MVHHSLHVSPKEFKETLDWVAAANDGLFSLYDLSHTVGDMFDSLPGMSVTNIGDEIANNLPDFLFSVVNFLDHIRNDAVYRMDYSRNANWMKDCDENPEKCAQTFIDAFPILFDGLQELKYKCSVSKANGGCSDESLGDPDSDLAHVFHMLGYDVSRELDVFKTGAEIAEEMDFVDEFKPTFHSMTVVMDSHPAFFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5X5</accession>
    <name>A0A061D5X5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0106180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766495.1">
        <property type="nucleotide sequence ID" value="XM_012911041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5X5"/>
    <dbReference type="STRING" id="5866.A0A061D5X5"/>
    <dbReference type="GeneID" id="24562850"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106180"/>
    <dbReference type="OMA" id="KRCYSSH"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="81805" checksum="EF68966D1E802691" modified="2014-09-03" version="1">METNIVKSRKSRAAKGTNAVARKKDRMSGGNRGRKKTKVAALSTDRDVEGNEDGVEYGVEEADNLEGEESDAMIGSESDEGSDADSDGAVSDDSEPSDLSDYDMDVSEEESDSDEEPDDVEFSDDEDSDSEFGDDVEEGCRVVSIEMAEQLVKQAQKQSDGAIRRLVVVYGSFIRRSVHYGSSPADSAKAAGSMAKVDSRGKRRRNERGMKASRGLSSMLTNVPNRYAPSNSEVYHYVVLEACSIVEQYVRATELSFTNERIVDVIRLFRRFLSSALLQLAYRFEDVDLCRCALNVIGSDAVMPWVVTLKSLHKEVVKLACSLLTHHKEQKVRIYSFQVLRRYLACVLESNYHRIQISQSPATGLKIERLSSQQARAFSNSSINFLLNRSYRTQISASSIERTLKNFGLFKLSQNCLAELYSSMPGANLYAFAFKSIRDLGVNVRREWMSANDRKKRERAPAKVSSSHSIVLPVYSWGFVEAVNVWVTVVVRCRDRLDALAYPLVTVITGAVKVKLPQIGYMPFILHMLTAQNQLSDGLERFVPIMSCIFHLLEQLRTKDINKLRRQEAEESRKLLDNVDDIMVRLRLTKKQLHASETYRMLYRHVSLLLTDHVGLLSLHPSFPEFIVPVRAFLNRYMKASRIQIDPSFRSFASKLLSLIEESASLIREKRANLDMETRATPRLKLLEAEAKQIPVYRFRMSQLLMYQHLSRAKVEGTVSAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D631</accession>
    <name>A0A061D631_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0300660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768347.1">
        <property type="nucleotide sequence ID" value="XM_012912893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D631"/>
    <dbReference type="STRING" id="5866.A0A061D631"/>
    <dbReference type="GeneID" id="24564702"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300660"/>
    <dbReference type="OMA" id="IIDFNLC"/>
    <dbReference type="OrthoDB" id="337284at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="58"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="388" mass="43894" checksum="380B3DD078619EF1" modified="2014-09-03" version="1">MGQSTSFRLPTCTKKSTYKYFVLCTLERKQSCRILLAFRVPASSTSVDYTISDSQLLRQHGIRVHDGASGQPRPADQRREVIALDAEAAHALDHYCDRQMLCVLKRYNYPAGRKMVNMKKRAKNEANALRRLRRCKRIVTLLDAFEFDGATYYAMEYLWRGTLWSLIRRNKGLDVSTTKAYALQVAMAIDAMHRQGITHRDVTASNIMISSTGHLKIIDFNLCRLLDHRDTRMNSFLGTYSCMPPEVLHCNVNSSLVSGGSTYTKEVDWWYFGSLVYEMLTGETPFTIESKDNDEQFYNRVIRSPNTIDFGPICDVDAADLITQLMQGVPSARLGAMGGSACVMKHKFFAGIRGGLTSSTIPTNYIEARIFDCIKVCTCGMDYTTYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D693</accession>
    <name>A0A061D693_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Triose phosphate/phosphate translocator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0107470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766635.1">
        <property type="nucleotide sequence ID" value="XM_012911181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D693"/>
    <dbReference type="GeneID" id="24562990"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107470"/>
    <dbReference type="OMA" id="INRQFST"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="105"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="439" mass="46672" checksum="67A620C97D51A358" modified="2014-09-03" version="1">MNRKPSLGILGLSKSVATRLTNADGLKFASDGVGIKSIRATRTFALPPKNEVTINNEKAIVEQGGSNINTAVVKSSVAPPVNVGRISDGNTSSAVATAKDALKSISMLSLWYAGTVMYNIENKKALNMCPLPKSIAAMQMLIGIPYFLTRWLAGIKAVPSISISNDGVEKVDPNQGVLQTIKSRVKNALARVRNTVQAYSSVLKQSAVFSMLHLLSVTALGAGAISFVHIVKASEPLFVSAISLLSGTGSMSPVTFLTLLPILGGVAMASVKDVNFNPVAFATSLASNVCASIRRIEAKKFFKQDLSKIGSNLDATNVSSLVTIISSLILAPLALLEAPQWASMYKSVLYKFGSKGLLQLARHIALSGFFYTLYNEVSFVALSQLTPVSHAVANTLKRIFLIITSSILFKTKITNMGLYGSATAITGAMLYSLSKHYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6G4</accession>
    <name>A0A061D6G4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767793.1">
        <property type="nucleotide sequence ID" value="XM_012912339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6G4"/>
    <dbReference type="GeneID" id="24564148"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207620"/>
    <dbReference type="OMA" id="LMSEHCN"/>
    <dbReference type="OrthoDB" id="364341at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="134" mass="14905" checksum="B25D4A73E0A3CB4C" modified="2014-09-03" version="1">MESQTEADVAAAHNPEVVDQVTTPLVLLAYNAPADYTLYNFQDMIAEKVGEVGQLSIIAPFPWQDRTSCPWKIICNDRRGYDAMLAMKHVWLKNESGGDSTSAITFVAGDLDDIPDIPFKEDEQLLMSEHCNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6J6</accession>
    <name>A0A061D6J6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 75, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0108620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766750.1">
        <property type="nucleotide sequence ID" value="XM_012911296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6J6"/>
    <dbReference type="STRING" id="5866.A0A061D6J6"/>
    <dbReference type="GeneID" id="24563105"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108620"/>
    <dbReference type="OMA" id="DHTQQNE"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="203"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="720" mass="80527" checksum="91F2853A379A6E8E" modified="2014-09-03" version="1">MKQNTALRGLLPSLASTGRRSGGVPLCTFSRGLARAETQSTAARAGALVGKGANGLGNRAQSHLTALRQLRAFSSGPAEGDRYEFKAEIQKLLQIVAHSLYTDKEVFIRELISNASDALEKLRFLEETREGLSGTKVDPGVPYKIKISADAESKTFTIEDTGVGMSKDEIVNNLGTIAKSGSLAFLEDPALNAKDKANAIIGQFGVGFYSSFVVSKKVEVFTRSFDPEKGAKGYHWSSDGAGSFTIKEVDDLPRGTKIICHLRDDCLTFANTANVKRVAEKFSAFVNFPLYIQEKESDVEITTQKPLWMETSASDEEHTKFFRYLNNASWGEPMYKIAFHSDAPLSIKSLFYIPEDAPSRLFQSASEVGVSLHSRKILIQKSADAIIPKWLFFVKGVIDCEDIPLNVSRELVQDSQLVKKLGNTVVKRILKFMLDESKRDPEKFRKFYDKYHYHLKEGLLDESHKNGPYREQLLQLIRYESSKGEPNQLITFDEYIATMKEKQKNIYYFCAANRETALASPYMESFKRRDRNVLLLYEDIDEFVSMNLQEYKDKKMVAIDSPEQDFEPDLETLDNENEAELELLTEEQRTKLSEFVQATLGAKVNAVKFSERLVDSPAVVTGFLSAALRKVMKATMKGAPDAGASLAAMPSTLELNPKHSINVTIFHVMQNDPEVAKTLVEQLYDNASIAAGIVDDPRTMLGRLNKMLELTADFARKNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6M8</accession>
    <name>A0A061D6M8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768522.1">
        <property type="nucleotide sequence ID" value="XM_012913068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6M8"/>
    <dbReference type="GeneID" id="24564877"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302400"/>
    <dbReference type="OrthoDB" id="448832at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="626" mass="71441" checksum="6320F48BB31BD420" modified="2014-09-03" version="1">MVELETSNEHGPEGHRIDAHEAARNVDSTPEYASQGDTARNLNTSATVEASGDGESTPGFAINEQRDAIIREMQLLMQNERMERERVRDMLAKQQKLRIGNPVSPGKEVTTMKLLTIAKEISGRSPAHGKPQLDERRDKRERAYYRNLHRTRAAAPPEDKGYYKQSCADGRDLIRVLDVDQLPLPMLHHMLCYSLVKHMPAEAVLQVISRIAMLRDNNSHVAYQNFLRDIGKIASPICRAEVVALLSRGYQSVSVPFMVDYVRRFGTFSRRFLAKLIQRHAQPQALDFLRYRAGQRQINQILTRPWALFGYVKMLKKSSAKTYMYHNLLARGYVPNETVFDRFHAFGTLDPGMASTILNSEKLLNDTVAFSDHTPKQDASRPSMYDTVLEAQALGLPLEDLVEESAPCKMDGKDDDVALPSRMSTQLVKIQTQLPRHQPPTATTGFHDVDRDLPANRSNITWSTPWGRRRDVFHFRGRRRTQRFITSRQNVHPGPRCWLENVPQRGQATLPQEHTDEQAQGTQKSTQTLGRKASARNARGSYDIVYNIEKVSYVLRLKRGVPFRRAAEVVTVEPEVAGDVQHEHAGSQKNCRPRTIRFLEHISHPLQGRRQRRSSYGHRYMGRFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6V8</accession>
    <name>A0A061D6V8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="11">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0208910</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="11"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767923.1">
        <property type="nucleotide sequence ID" value="XM_012912469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6V8"/>
    <dbReference type="STRING" id="5866.A0A061D6V8"/>
    <dbReference type="GeneID" id="24564278"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208910"/>
    <dbReference type="OMA" id="VTNRNAI"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000001">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="453" mass="49611" checksum="F4FDC45F7CF162B3" modified="2014-09-03" version="1">MPAERQIALPSDHLSLKDADPEIYELLQEERQRQRDSINLIASENFASIACMEATGSAFTNKYAEGYPGRRYYGGCEVIDKMETLCIQRALKAFHLDEEEWGVNVQPLSGSPANMEVYVALLEPHDKIMGLRLASGGHLTHGFHVGKRKISASSIMFTPLLYDIDQKTGLLDYDQLEALAKAYSPRLIIAGASCYSRYWDYKRCREIADSVGAYLMADIAHIAGLIAAEEHPSPFEYCHVVTSTTHKTLKGPRSGLIFYNKKLDPTIGDKINAAVFPAMQGGPHNNTIAGLAVQLKTVMSPEWKVYVKKVIENARALASECQKRGFEIVTGGTDNHTVIVNVKPFGVNGNKVEHICNASGITLNTATVPGDTTMLNPSGVRLGSPAMTSRGATPQDMAVIAEFILEATRIAQSLQEAHGAKMDAFKAGAAGDERVAELRRKVTEWVREFPIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6W8</accession>
    <name>A0A061D6W8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768632.1">
        <property type="nucleotide sequence ID" value="XM_012913178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6W8"/>
    <dbReference type="STRING" id="5866.A0A061D6W8"/>
    <dbReference type="GeneID" id="24564987"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303500"/>
    <dbReference type="OMA" id="HDYVIDI"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="862"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1105" mass="125723" checksum="1A47FA568088C98D" modified="2014-09-03" version="1">MEGHNADGRMGHNHRYRVILHGPSVWKGVVRPPDADQQAPFIVAFEPQNDLVAMQQGTLELNDFIIDEVTCTTQIFSIFFFEMQEQAVNAQQALSRSLDRLQTVYDIFQNTRVIEALEQALGSVHVPLEVVVSRVDLTGDEAGNGSLNADKESYTIRMAVSQGLSTVTPETNLLDVARQAISRKGALLNRVSISFYELPANRATSVAQTPAHVGLSGIVGKSAKSTPRNITRGTTPCARIGKAVVDLYSKRGLINPPTPWLMAPYNENVLVAASPVLKATVASQQLEELLQQSDEGLRSISQDQYVHEAELKNLNLPTETNNDAEGIAVEQVSLEINGGLENQGFDFDDVRPPSSDRTNASGIANAVDEALQLFDRWNFDDFEVFNVPEPVIQIPKSSSRKVSIGVDDERVKQLEDENKELHETNTNHLQEIAYLRDQVDELELDLRRQVDTVKLQHEIETTKLKEALKDRERVISEMNSARSSTDAGLTLESAREIQTLNEEIDSVTEEKQRLLKQVKLMTEERNKMAEELDSLKIRMSEVTKMENAIKQIQDEKEGHIAIMRDCIGKLRKEKEGLASDLDKHRRENTKLVRELKHAKFVEDQLKETLKKFEGDVAHLNDTEYELKASRAALKERDAEIKTLKLDMERLNGERTEAERTLNDLKKRFAEITETVKNVEEELFAERKISLEQKETIKNLEANKCALEVEIKDGETMREKLKQDKSEAVGRYLKEKIKHDGLLREHELKCNRLSGEVKELSTKLNLVVHQHDQMRIKYASHIIKSSITSGIAERKMESNEKATIGLVKTVLKFKAELARKRCQLRLMAKALQMPTDTTDKDILTELRKPRTLDSLTQQKLKNYEKLKTVHSKLKTEKDELAKLLEVKTSGYNKYVRRHDQLHEENRRLNTLLASERERLSAMQMEAKRQIRDEVIKVNEDKRLLHAKQCELMMENQILKQENAMLKQRVALQLDSSGIDRSESVKSYRYESLDGNKLVIKKLSNMTNVLSSGGVKHGGIRCRISDTTFEDDLSVDYTESIDLDRQRTIEKPYIAGSPCAYKDTKASLYSRKATLEKLRTKQQPKEDYRAEGIYGGSGIKNRHPWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D719</accession>
    <name>A0A061D719_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768489.1">
        <property type="nucleotide sequence ID" value="XM_012913035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D719"/>
    <dbReference type="GeneID" id="24564844"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302070"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="302" mass="33452" checksum="7369DB9B7CCBDED8" modified="2014-09-03" version="1">MVYTSLTEAPHNLKEGIDWLMALKGSCGESTLKAMVGAIHHLFSKHSDGYKQLPALEKMKSISREFLEKPELRDNLFVKQLLSRFYTPASTANTGFKHLLARYSEEYARVVGVKGARPEYIEESLRNVMDGFGKLLNDIKNPDKYKSAYSAEATWEASCAKDPEACAVVLVGMAPMLYAGMQSLSNAVFSKSGWWSTTVEYKAAGDVLRPLGYEESECRAGMNGSYIYETFKGLDADLFHKTYDLAGFDIFYGSDIVQKLPVKQPVVEEALVAETAVDPVQAAKTANTRKPGQSGRRRKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7B0</accession>
    <name>A0A061D7B0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768043.1">
        <property type="nucleotide sequence ID" value="XM_012912589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7B0"/>
    <dbReference type="GeneID" id="24564398"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210100"/>
    <dbReference type="OMA" id="MRENIAS"/>
    <dbReference type="OrthoDB" id="428826at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="556" mass="61808" checksum="E41C846DC986A0FF" modified="2014-09-03" version="1">MHVTPGIVNHPEGGSNFPMSTRAGYPHQPGMPGYALPGLMYERGDEQHNMHAGYNSETVTDAFYDGIVNPMYNFESTYLMRENIASVPENNSHMVNSGTKEYPEGVKLYTGNATPESRFAYNNRDVGYYPGWYGNGYQYMGGYGHSLPPAVNYGVAHDSKHIAQPQVDIASVSTDCDMSATRLQYSSGNREMGQHSTYASDSTQSAEQSVVSETSPMLQATSTPSTPPKRDSNLMHNEELNVTHELAPGPLVYRNGYSGAYYNDHASRQIPDDIGDRAYMENGLHGDEKHMNRGRNGWSDITYPNYATMSGVNAVKDPGNHRHAVLPRFYNVAQAQYATPVVYHTNGWTQKGYVGDTVSPNRYAAVPEVSGYYDQSSDIGAMKAEDYITGSMTDMNGNQMEQTSAPRIMSQMSGVYDYCYDRAQSSNDFYNQVNGGNSDTQQRSTSMDYGEEPLESSSKSTDGIKQEINIESQKILNRSNIDFLRMSDSLWQSLRSTGMFKLGNKGRAILKSKISKQLKMNPQLRMRALCISGVRRATTRQLFQLAQICGIKSHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7F9</accession>
    <name>A0A061D7F9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768103.1">
        <property type="nucleotide sequence ID" value="XM_012912649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7F9"/>
    <dbReference type="GeneID" id="24564458"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210670"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="121" mass="13784" checksum="1BF448CE563F1B71" modified="2014-09-03" version="1">MRAPPSGTLISEHHQFSRPCVVEQRRPVASTNLHHHELAFWKRRRHLRFVEIVVIQVAVVPQQLRGSWGHEGGHYALPPGGGRIEVRRHPPLNSSAKTERPSTVAAETQSANICRRVTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7I0</accession>
    <name>A0A061D7I0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765871.1">
        <property type="nucleotide sequence ID" value="XM_012910417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7I0"/>
    <dbReference type="STRING" id="5866.A0A061D7I0"/>
    <dbReference type="GeneID" id="24562226"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100140"/>
    <dbReference type="OMA" id="MRAPMAN"/>
    <dbReference type="OrthoDB" id="343414at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38214" checksum="A9AD901092A100D2" modified="2014-09-03" version="1">MRAPMANVPQYAPIQEQPKEPEPNPEQEGFTTKLKLTIPDNFEVGVKSPADKTDPNMENWKASGIGRNDSPEEREFRSRPGNVDTDCYFMLIERKNENSAMLVPVSQYLMLDPVVTPRTNNSTAGPTLKSEIVVDARLRRLAKVDDLSGADDGARGRDGNAANRDSRQRVSKINWDYEGAPSDDEELYPQEEADEPDEDPLNQPHLSLYGHKLRSLLQQQAEREVDDELEAYSDDEEGSQVSAPGKQQRSSDASESQSSKKAKLEADKATSIEERVTTFLLENNGKVQVKSVLSHFNITAKNEDFRLIQTVIQKRCTMSVEEKDNRKIKFIALKPEFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7I6</accession>
    <name>A0A061D7I6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765876.1">
        <property type="nucleotide sequence ID" value="XM_012910422.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7I6"/>
    <dbReference type="GeneID" id="24562231"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100190"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1500" mass="167046" checksum="5B7F4B3B6740346B" modified="2014-09-03" version="1">MASHGVPLKTLKDCLQFLQWLENDSNMQGLVGHRLDKLLEKRYENVNASLIAKELSQFLNSASTFHKKLCTKPSGSYTGNKSAKNVTNALLDCIPRFLSAIYFLRYKVDVNFKALGGGDWAYKDVGVIAMYARFHKDVAERMIRTAGDIDKYLITKSGDEYGGIVPGGFEPGELKEGYRVSRSEGYNPGSAMLGDLQNILEKYSNQNRQNYFLDVFSTTVLSNSGADTSNVANALRLVQDFCKIFDEVNESDFENHLYTKDRCFDLPQLQKHCKNLIGPLNKLFNQDAFSFTGYAREYKKLKKQDIAKKMASWFKRNLETVMRHIKEIEGFTSKKNFKSVSVRKGTAPSTHIKAELEKYFTENFIRYGFTFYHHEYKTRDPPYNVLKTDWDGVIGMLKTPGSGLDELLQILNGEKCKQRMKDEEDEEAKEEPEDMELLNGEMVPVSKKEEPPPGKVPDDPKEVVPEMKSAPADGPPKSAATRAQGVDSPSEKVEGAQNQGKKAEGAQNQGKKAEGTPNQGSNHSVANTSSSPVLQAVQTQPPSDSRAGYEPPGDPVPSSGQVRDGQAVSSGSVPQGGQVAQSGARDDATTSSAAASASGGGGASRGGGGNNRINFPFDVDTAIQKFTKQNQQRLKEAESFLDNLEKRKENRVAERSKEDDYLQSELKMLERSLPVLGGVTIPNPVTVFDGLDGLVSQDDTQSLPDPILQQQEADDEWKFEQQKAYEVQEDYFQKLTEVINRSQHGGLFNGLKTTVIKDSASHPFYDGTLTRIDGNKLQHPSHTNEQEKQKVDDANHFWVKFHEQQKQRESDELDKIMNETDKIKKQVEAKYAADQIIGREFFEQDLLEDVHEELIDIPPQPTVDGYAISRETNVKTYIPPPVIDTEPADLLVERQNMWLFQGGTESGDDLDSKLEMDIENQALRKNASSLYGFAVPNPVNHYSLLDGTTLHDDSQSLPDAARQQQEADEEWKGRLQKIHQQQESDAKTLSERIKQTQYDTLLKQVEKNVPEGDVIKYSPPDLTKIGTPIGYPLKHKKTDYPQFYDNRSKESQKFRPAGPQGIVLSQSGQMKARLPPLRKKSHVSPISMQLDGMPPSILVDSIGYDLTRSPDQKVKHDVPITSHYTPPPPLTGKPTDNNAIVSDGSFVEPATLPPALPPPIDFVFKAATPRLEKVPDPDPLDLHIDIPKLTLPDKDLDFDLDFDDDSTHIKDNTLPNPIVPSTHAISFTLPPPDPIQSLPPPEDFDKKTIKQPDITLCLSSWATPTPTHGSSDIPETELFPAEAPRTVRDMLTWLAGLRNPKHHDTLKQCINKAFSGHHKDPSQLAIFINHAKIRPGDVFDILQLTAMFAGSVLTSIAPNWKANVSSRIVKPNSSTQSEVPDCCALLCQLRDYVYACHHQLQFLKAQCNRDKLSGGWKNDEYGSDITASNSPLQAFLTDGWDSTFETHLFDPCNLCHKSRIRMGFKKNDLPKTSQLGSVISTILSPSCGGEEHGALVNTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K1</accession>
    <name>A0A061D7K1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767050.1">
        <property type="nucleotide sequence ID" value="XM_012911596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7K1"/>
    <dbReference type="STRING" id="5866.A0A061D7K1"/>
    <dbReference type="GeneID" id="24563405"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200210"/>
    <dbReference type="OMA" id="GFYRFGC"/>
    <dbReference type="OrthoDB" id="361497at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="101"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113853" checksum="6779F81B7DA1A0BB" modified="2014-09-03" version="1">MCNAFCSARVHIRSSDKTMIEETTLKVGGARKTKTHHDGIREKRVIRPAAKRRVRNSRHVDRGEPPEPANDAGTCDCGCDRQIKRRLSLLLHGFFASKHRWTVALKVERMRPAELERVSAAIQENGLHAMASDNLDLDTIELDISRQQWISDHEDMRRVRQALLVFCLVNNVGYWQGLHDVAAALVRLKPKPTVGELAAILEKLIWRFASILMRTTDENIVTDAGKMAAKWRLMFLFFFPRAATELERLSDSNSWNINWFLTLGFYRFGCAYVALAYAYTAMLCSAGCMTAFMYHELGYLGIRGYLTYRLQKNQKLSHPNFNLFEEEFDEETMTLAVTNSKKIQLTPEELINVSRNLYDTLNDKECEMAEFPILPILKMSNFLYNRSPLILYKNHDLQPKNVVQIGISDIFKENETPRSAEPPTRQSQVVARGILRMLPEPRQHAEISHRLNIELLNVYLKKLYANVLKKSFIFPSRFEGAIARKATFTYHIIDVRSQYLTYGETLQFFFGDTNVSYLTESQLNDFARGLNHTQTFTVWLIVTDDGFENPGDSASTESLNRGIATYWMLSRTCTGVAILKGGYKALLKWKNLPVPAKINIPFFKKMWDWMPTGRDQGSKIAIQNVVAAIDDTFSDLSGRIKHEVTSRIGLFRRNSRRSAISTDGQEAHKPKKKVACMRYIVRVAIETLGSVSFSSNGAIKLNGIIWHPSTFARHANNTLASAILYLAGLFQITSADGFPEIVPRGAHLKMARDITKRPMSDFGERLVNCTMLLHHTRRTTDMVPADRVLAVTVKWAHLCAHAMHKSVIESWWVTIATDTTVNAAPLAGEKVVNTYIAISLEGGYGSDYDDSSVEESECDGDFWKGKENVHYHHWGKQELDASSSRLVESFAALGHGLEEIKGGNMVERRVAPIDLSLLNANTALTYQWAAPREPSICSERRTRVFSRRIKPQSKSVEVTASTPNTQSVPINAVNRAKNVFFPRNQLKRALIARNISGQGHNTYSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7P3</accession>
    <name>A0A061D7P3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="9">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0306150</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="9"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768897.1">
        <property type="nucleotide sequence ID" value="XM_012913443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7P3"/>
    <dbReference type="STRING" id="5866.A0A061D7P3"/>
    <dbReference type="GeneID" id="24565252"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306150"/>
    <dbReference type="OMA" id="ENYETKW"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 13" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="67"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="152"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="367"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="10">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="10">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR96711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="461" mass="51137" checksum="4D32668E1623C91E" modified="2014-09-03" version="1">MAVMSGIVRLNGFRQMRSPLLALGYLCSFITRPAVSDPCRRRLSTSVNSHVGRSRNGTMEKIVSRNPIVEIDGDEMTRVMWASIKNKLILPYVDVPLEYYDLSLPNRDATDDQVTFDAAEAIKKHGIGVKCATITPDEARLKEFSLKRMYRSPNGTIRNILDGTVFRAPIMTKTVPAYIPGWKKPIVIGRHAFGDQYNATDIKIPGAGTLEMVFTPADGSAPQTYKVTEFKGPGVALGMFNVDASIYGFARACFNYALDVKMPLYLSTKNTILKSYDGRFKDIFQEMYVSEFKPKFEAAGIFYEHRLIDDMVAYACKSEGGFVWACKNYDGDVQSDIVSQAYGSLALMSSVLYSSDGKSFLSEAAHGTVTRHFRVHQQGGKTSTNSIATIVAWARALEKRGLVDGNEALANFGRKLEHASVAAVDAGFYTKDLAIAIHGPQTQQYLDTEAFIDKVREYLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Q4</accession>
    <name>A0A061D7Q4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768208.1">
        <property type="nucleotide sequence ID" value="XM_012912754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Q4"/>
    <dbReference type="GeneID" id="24564563"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211655"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211655"/>
    <dbReference type="OMA" id="KMKVYAF"/>
    <dbReference type="OrthoDB" id="361097at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="266" mass="29353" checksum="81BCF174AD1F4447" modified="2014-09-03" version="1">MAGPERKLSRSLQSSAGSADRHMIRRGAAIQALIDLSEHNSLAISNKRFALSRLKANAAEKNGQAAVSDDPGPLRFTQSQLRLLRQEQLMLMAENERLVHELQEIRRCRIPGQFRPGQARAVPEFRESKLSKAIDLTLSGGRDTRLQAARIGFLCAVVARVRIRLLSSAFRVLSRQPLRSLLYASSRVHNSGQPSIRQVMLSCMVLETAIRSKVQRIKRLGLRLLRNPGAGSASRLQSAFGDYSRAPGGLSQSESRPAGKFCSCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7X4</accession>
    <name>A0A061D7X4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">valine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0305510</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768834.1">
        <property type="nucleotide sequence ID" value="XM_012913380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7X4"/>
    <dbReference type="STRING" id="5866.A0A061D7X4"/>
    <dbReference type="GeneID" id="24565189"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305510"/>
    <dbReference type="OMA" id="LDTWMDS"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="23"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="688"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Valyl-tRNA synthetase tRNA-binding arm" evidence="16">
        <location>
            <begin position="903"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="943"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR96648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="972" mass="109663" checksum="4291182DBECB7161" modified="2014-09-03" version="1">MVPKKTLGELQSAYDPKAVEEGWYDWWSSQGLFTPSSESEPNAKGRWVAVLPPPNVTGKLHIGHALTVSIQDCLARWHRMRGDTTLWIPGTDHAGIATQTVVERMLMQTENKNRHDFSRVDFVKRVFEWNDQYGSNIKTQLKRMGASLDWTRDAFTMDAVRSKAVIEAFVRMYRDGLIYRATRLVSWCPHLSTALSDIEVDTFEVTAPVRIKLPGYDSTVEVGSLWIFKYQVKGADPEKHISVATTRIETMLGDVGVAVHPNDARYRDLVGCELVHPFIPDRKLVVVADEHVDPEYGTGAVKLTPSHDKNDYDIAKRHGLPFVTIFTDDGRINRNGGEFEGMHRFECRKVIEGRLKEMGVLEDKVPNSKPMTIPRCSRTGDIVEYMIIPQWYVNCQELAARAMEHVRTGELTLIPSSYVSVWEMWLGNIQDWCISRQLWWGHRIPAYRVVSAELNGEEPWIIAHDQAEAEELARRQYPSLTSFELKQDEDVLDTWFSSGLFPLSTLGWPDEQHPDFLKFFPTTLLETGNDIIFFWVARMVMMSLHLMGKLPFSKVYLHPLVRDARGEKMSKSKGNVLDPLEVIEGTTLESLNEKITNSSLPAGEIKKAIALQKQQFPQGIPACGTDALRLGLLSLTRQNRAILLDVNKIISCRHFGNKIWNALKFAMPKIQGLRVDMGTVPSTLQWEDRWILLKLNEYIAKVTEAFENYQFGDAVQAAYDFWLYQLCDVYLEVVKPRLPSFKDVAEVGPVVEGAIYALNSSFSVGLRLLHPIMPYITEELYHHLPEHLRTSDSICVAEFPTVQSAWEDASVDGEMQLLKSAVHSLRSLAVTLGIPPSVAKTGFLVATDPRDSGVLATLSPHAATLAKFERVSVVSAGAPELAQCVQDVSSSYVSYVQVDSSMDLSKTTAKLSAKLQKSRQSLQGYQKKLTAPDYESKVPESVRELNAAKIQELELEISQLERAIAELERLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D822</accession>
    <name>A0A061D822_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766051.1">
        <property type="nucleotide sequence ID" value="XM_012910597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D822"/>
    <dbReference type="STRING" id="5866.A0A061D822"/>
    <dbReference type="GeneID" id="24562406"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101940"/>
    <dbReference type="OMA" id="AQWGHLM"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="442" mass="43987" checksum="5A97CB043D531489" modified="2014-09-03" version="1">MADSSGDKPTHLPTTISIGKGEEGNEGICGTCKGSTNIENKGANVGNMGSQVAGASDILTSQAAVTSDILASLAAGIRDILASQAAGIRDILASLAAGIRDILASLAAGIRDILASQATGASGILAPPSAGAGGILASEAAYEGSAIPPREAYEGHRFSSQEAAIRDILASQEAGIRDILASLAAGIRDILASLAAGIRDILASQAAATSGTLSSEAAGIRDILASLAAGIRDILASLAAGIRDILASQATGASGILAPPSAGAGGILASEAAYEGSAIPPREAYEGHRFSSQEAAIRDILASQEAGIRDILASLAAGIRDILASQAAATSGTLAPQAAYEGHRFSSQEAAIRDILASQEAGIRDILASLAAGIRDIFPSLAAVAPPPFIPQVPVARRESLPQEAVAGATPSSEIAGASGKRPHAEVTRGILASEEAIRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D857</accession>
    <name>A0A061D857_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin central region family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0102340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766091.1">
        <property type="nucleotide sequence ID" value="XM_012910637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D857"/>
    <dbReference type="STRING" id="5866.A0A061D857"/>
    <dbReference type="GeneID" id="24562446"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102340"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="600"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="693" mass="77639" checksum="9622F4A972F7CEA8" modified="2014-09-03" version="1">MEQLIPLVSRLHRILAWTGESGLELPAIAVVGAQSVGKSSVLEALVGRPFLPKGTGIVTQRPLILQVCELGGAKQNVQLMYDADAVEHGEFAHKRGVIFEDFNKIMAEIKSETERLLGNTKNVSPVPIFLKIVSPRVVDLTLIDLPGITKVPVGDQTHDIEHQIREMIMERISSPSCIILALTAANTDIATSDSLQMAREVDPHGLRTIGVITKCDMVEDGFNAVDVLQGRVYKLRRGYVGVVCKDKSAAPDATHSTAEEDAFFTNHPIYGPIAKRCGIRHLSLMLNEMLTFHIKQMFPCIKSKLLAVMHEREMELLSYGFGSSDLSASPGGCLLHFFTAFSQTFRDIIHGKRSSRQHSTQLFGGARINYIFNDSYLKTLKAFSPLSGLSDIEIRTAIRNSTGPASALFVPEIAFENLVKKQIRLLETPSLQCVDQVYEELLNILESCEIPELNRFMNMRMRMLVVIKELLRQCVEPTKDMIRNLIKIELAYINTNHPDFLKGNAMEKACNAQSKQQSAGRRSNASTSSGYSSYSSNQYDYHGDRYDDRLGVASRESKKDSSAKHVDNAGDEEPRPLWLPNIPKAVSLGTEPSEREVIEAELIKTLIESYFSIVRKNIADAVPKCIMHFMVNKTTDSIQQELISHLYKQELYEELTAESKHIIQRREQCLESLKSLRQCVADLNELLDFRIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8A4</accession>
    <name>A0A061D8A4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RPAP1-like domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0203060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767335.1">
        <property type="nucleotide sequence ID" value="XM_012911881.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8A4"/>
    <dbReference type="GeneID" id="24563690"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203060"/>
    <dbReference type="OMA" id="WSDESLM"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="240"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1403" mass="154466" checksum="05CB6A204E0825D9" modified="2014-09-03" version="1">MKGWEYDPEVRGADSDNDFDIIEHFSDDEDAKPSQAAPPTKPSTAQARSTWFPKATHRRLLGYSLSRSQFTQAEPQAARAGSSHGDIRAPTDKPRQNDHIQGHIDEINRAYGAMGSAHDAALPDIASMTEEEIKAEQQFLYEKLGKDMCDFLIQRRLRKMRERNGSTESAGGEGTACSPPHAISPVVSGGKGSTYEPPKALSTVSFKVDAEELRKLEWTNPVEPDVSGGPIDAGNVRLHQLRFDFEGHLLSASGRKDGERHRHESSLYNHGKNPDQPGYTIPELLELMQSTFKPQVQIATHTLCNIVRNAHVSSPPYFGFPRERWLRYVTHDANMVGRMGYAVMEHMGTYEVLGSAMRCLAIMLYGDMDPESFGTQQASPTADSSVVRSNTIWPMQELLAGLHIRDMGVALHRWNPFVATFEGASSAYAMYERAKSAGGNRATAGSSANNTSTSGPEDTDTMRSRLSETTDEAESRHGGGKGAAVKSVRFADQADDTPMGEETRDSRMIGFYLDALNGEFISLEIEDIKHRLAVATGIEETDYYTQSNMDDTVYLIVRGVIGRLCNVVSQHEVSLALKSRFITFVCGLLMRLGEPFAQALVKCEAFCDLLESFTASLIVGTEQHKKLSEVIGESGADAELRNDRIHLTSAVLCCMRLLSVFDDRAFATLLDRIGAIALVKQTLTFTYGSQLSQLFNAAANTPPSVKPFSTKLVMPAVMAVRCLTVWALQNEYNDTLDEIVPVIELEVSTLCRLIQMDGSTLNSFISANGVLLMHIFIHMATLLEGEAGKHVNFIWDVGRVHDLLVALCEMGEEKSSIDARLLIASLFQLQSVYMRHCKRNGSGMKLENVTRSTVVIKSIERYATAISEQFCQQLVKNDVFNLGYRWWSTQIMAGNEQPIVVAREGNKDVDSYVVPVHIANCMLEALEVLQTEDETLYNSVRANIEPKFKLMMNIIVERIALMHKDRTSGTVTFPGDEGIIVQKPIPMLESWSGFILRVVRVIGGYSDQTRGGSAEHVSPTSVTSENNDDANGDKDKSSTWAAGLFAALTISGCYETIADIWSTLSSVCGPNNDVSIGLGEQCKHVGESNAISGDGADVVTAFREFNEMVANANTLGDSSMPIMTFIAFVPTFFISAIAGGTGAAANDTQILLLEALNKRGRFREEFLKWVPPFDVANSLIKAVVSADKNANWNVDRRLLEALEVLVFGRLSILDEETSLSGTRAASDVTELHDTIDSIVARMVSMNVRNHNKHLLMASEGSTGSTPAATEHDELSRATVNVINRFNSGSGDSPYVMAVIMLLISAFSRLDSAKRIWADTDLMVLLGRNLVVDRHTLEIICMHPDGHLSLGNAMVYLPNFNGSEEILRSQRRLLQEFGPSDLESNNAIMLIAMASLRKYDRLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G7</accession>
    <name>A0A061D8G7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0103540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766226.1">
        <property type="nucleotide sequence ID" value="XM_012910772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8G7"/>
    <dbReference type="GeneID" id="24562581"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103540"/>
    <dbReference type="OMA" id="NINIHCY"/>
    <dbReference type="OrthoDB" id="361225at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600145" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="180"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="457"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="596" mass="67222" checksum="F0A73E1B2C6E236E" modified="2014-09-03" version="1">MMWFSVLVGAALACVCAVENAFARTPHGRPPAPPLIFTGKSGSIKYEVTLDRVTLGQPHEANIVCGNDDGTPLGGEFTLYPSDPMTKTLLPLEGDDLEEAISKEVLLRNISRSTMLQIETSKHRGTGSFVKVKYPINALIMAKDPHNFSINYACKYQPHDKSQPPYYKWLEIKFKYVYPMAYGCESGNDMLFKNSVYRFDSYKSRAQHAVCRINPEPNLLFGIYCKPGEVLFPEDCVSKHDMRKLGGLIERYELDDKSAAAIRGYEVHTRLKLFKISPKAMDKEFSVSCQCMAPDGEGRQLSLRNHVNVEVNPVQTLQYNTRSLQHSMAVMELLRPGIRLTISAPPNGRWNVGYLGNVESNLTPTDPTHYVTIGPGKVKNTLMRIHQFIGAKKLSIAQHSTVGKLQYVIHYKPDSVWVLKNEMQLMHYKWRATRMDGPKPVDVSVDVNLPIIPTDPHTYGCGVDSRDLFRYEGFELHQGKHEYETVCKINPYVLSPVGFYCPKHYTLEPAGCFGEMLHTESGRVVNLADYAPHANPINSANIRVLDFHVPKSMRRRVKYSNDELSCRCLDPDGRVHASITLDLRQPMTDKNPPAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H4</accession>
    <name>A0A061D8H4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768458.1">
        <property type="nucleotide sequence ID" value="XM_012913004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H4"/>
    <dbReference type="GeneID" id="24564813"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301760"/>
    <dbReference type="OMA" id="PVTACEK"/>
    <dbReference type="OrthoDB" id="361803at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025677">
        <property type="entry name" value="OST-HTH-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14418">
        <property type="entry name" value="OHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="376"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="571" mass="64855" checksum="914702357C4CC414" modified="2014-09-03" version="1">MYKGGNRRASFETQKVSDDAFTAYLRQYEVKIANAKSTKSAPSTGALSLNHSSIAELSTTSTQNNRSKYTRKKSIANAGSQCTGTEDPLQWLLGIPLDGDQSDTPATSECQRWQDRENVRNPCYSGSHMVMERRGGLTWIKSPSGVLVPHIENTWLKQMITMLLPDEQALSKFLKTLQTCLEEAVLFLYNEGIKPYLGDVANQMKRSIADNFWSASEVAFVSLHCKDTIEMKIEQRVKGEMGWVVYLRQVPPHFLGFVDTHSTIDPYSNYHWRALNKFAVDMMTANRPTIKTDDQGSETTLAFTGGRYAFAERLREKVHAFQSMRLGEVVHLVQLAIYSGVFVYAQRILLPVTACEKTAEEMFPRVKKVRHPVCSSLEEVRHIVSLLVDNRKNGLVLAQLKQQFMMQFNKELNPLSFGYRKLQNLLLSDNFNRQYQLFVPVDSPHRTHIQNRKYSIPAGCRAFKQSKLRFDIEKFWSPTEEWYDEPSCEGLTELPVNIRSALEEILDGEEDDLNYQYANYALPLADCLKEDDTSTGTHASNCSTGRGTTTSNTVDIGESINDRSNDYRSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M1</accession>
    <name>A0A061D8M1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769247.1">
        <property type="nucleotide sequence ID" value="XM_012913793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M1"/>
    <dbReference type="GeneID" id="24565602"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309640"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="170" mass="20039" checksum="01CCB9EB909D7F53" modified="2014-09-03" version="1">MQNLLLRFLEQDELKYPWLVKELLKRFNTRMAEDPKQFAKTLEQARKSDYKNVVRIYLRGRSHITKDPRRIVNGCENFLQISRALINIHLRTAQKQHGMNHVRNIRKVAQKSLLELRQCYTQAHMLNCKVRLDDILKVVGYKGSEFRADMRGSDVLKVLSGVDESLLYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M7</accession>
    <name>A0A061D8M7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766291.1">
        <property type="nucleotide sequence ID" value="XM_012910837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M7"/>
    <dbReference type="GeneID" id="24562646"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104140"/>
    <dbReference type="OMA" id="CHTATYN"/>
    <dbReference type="OrthoDB" id="365659at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="224" mass="24159" checksum="0B0661FF8C5C7AF1" modified="2014-09-03" version="1">MGPSRGEPISLADVWNKVKGFYLLEIIFQLKGISISVDFNRNDPIRAQQRRIAEYNRKPSIYVEHNPLKSCLGVPATVAGYVGDLFQPAAHLQEGHHGCVAEAKPSRDLAAGAPSSPVCDVIDLSVYKVLQRALCYVGAGLGIVGVGLVTLFGLFTAAGATCAVTTCNKLSDDCHTATYNPNDNEVYYEGKPIVNTHNSYTPGPINAFAPMYAPSTPLHWSHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Q8</accession>
    <name>A0A061D8Q8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766316.1">
        <property type="nucleotide sequence ID" value="XM_012910862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Q8"/>
    <dbReference type="STRING" id="5866.A0A061D8Q8"/>
    <dbReference type="GeneID" id="24562671"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104390"/>
    <dbReference type="OrthoDB" id="365041at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="122" mass="13636" checksum="2541514F858AFA1E" modified="2014-09-03" version="1">MRKFLAKATILARMAAIRLNRPLAAAGKDDKMSLETSLRATALLHKVVPILETAQVLNHKRPVASVGRANCDVGAEATGGTSGIPTQVKLKPIEKCHNVREQEWRVLRPGKERETRHLRWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S7</accession>
    <name>A0A061D8S7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAT1 centre domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766336.1">
        <property type="nucleotide sequence ID" value="XM_012910882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8S7"/>
    <dbReference type="STRING" id="5866.A0A061D8S7"/>
    <dbReference type="GeneID" id="24562691"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104590"/>
    <dbReference type="OMA" id="NYDCPVC"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAT1 centre" evidence="1">
        <location>
            <begin position="72"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="258" mass="29736" checksum="AE2E84DA7A5F55A1" modified="2014-09-03" version="1">MDNECPICLDVITPLSEKKMLVSKVCDHKIRSKPPVSSQVGQAQCAICRCHISRASFAPFDITQAYYSALRDARKRVLQVYNDTRSNFKDTPEYNKFLEEREEMINTLAAGRNDLRWEKVETELKNYERQQASRISENIVAQQNELRKRVKYIVETEKTFYEMVDKGAPFNLWKVEDLVHTLQRTHASFFAEDKEVTSSTGECKPLNAAIRNDTDIPRRMLASRDEVLACDIAGGYNTALVAERCQMQVDLMLLWNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8W9</accession>
    <name>A0A061D8W9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formin homology 2 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0204770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767505.1">
        <property type="nucleotide sequence ID" value="XM_012912051.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8W9"/>
    <dbReference type="GeneID" id="24563860"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204770"/>
    <dbReference type="OMA" id="RRFFWDP"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="1126"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="745"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1558" mass="170793" checksum="607C7D532B63576A" modified="2014-09-03" version="1">MEYVDYESLTEAELGAMDNLTVRSKVSELPMSSSGNISPYALGMSVRIDLEKRRRATQTDKERDNMVGKAFLESCGKFGSSDKVVEAAAILRKLDTNCSAMVYREALATRMQLRKMALKNLSGENFAEALLQAHYSLLLAKKFHMDIAKTPLSGEMAMELLILSKCYAHVGQFDAGRTHLIEFRFLVEQTILHLVKPAAAGDRAAPQPTERKAVINCDPKVFPNIVFTLAEILTMYDLHEDAEIFFSKYLMLCEREFGGDSVGLSEAINSVCVYLLRSRQHMKALPLAVKALEIQKKHFGDYTSETPDPRVAEGYCNVGMLYRMVGNPLDALHNLLIAIDMKMRIFQDREHPEVQDIFLSLGCCQHMLGNFHAAASIYREVYTTRCDTLGTTHPLTVAVKHLLEDLDRDIRVAPDPGAGAEKGKSLPESTEKIYARVKALGAEMGHPSKRAPRGAPGIEVCRIQSLYANKTKHFRIPTASILQTHECIIPRKEVIELSRQISIQYAYKRLPIINIPRMARGRLILNDSQPVMECNKDASDLLLEWDFRPPSVTADGDVVGGDPKLSADVLLFIPIMEDGKPVMGFYSKPIFVPNPGLFHAFKRAKTIRDFNVEPSPPTTEGVKRRDSNTTGTLDPTSSGATRDSDPKEPKHTVPLVKVKPLLPPKRGDAVSAPKEGPPKKLAPKGVSKPSIVVAKKLPLKPKGDVAAAAAAAGAEKKTAPPPAIAPKKGLLKGMPKIVQPKIIKTLGSPRPDDAAPPKSSPVPKKEAPKGAISQGEGSKTEDPAPSTLPLVEQRSMRLGDLFSKKLDTNANNRNAKFLAKIGNLAKIMVKPNQVKAPGAGGMAMVKQAAPVTGASPPSSLLDSDADTSLSDLDDEEVFMPSPTLREDPTARASVVAMPPRNDKLPLDLKSIHDPLPMDILSLVRGICSHKDDDTSLRCMLLGENGRPLAIVPWQIDMMSLTLAKSCLSMELLEKYSVATEKKDDSSEASKEAQIAAYRKLLAGEGLHDLGFSDLIGNKAMQSLAGGEDALSSGLGMGLPPSVLANLRKQAEELERKAKEEAEAAAAEKDAAAKAGAAGMPKVVPILKKEAPATKKGAPPMKKGAPKGLAPPGMKKGLPTKSKGKGGPSSMVDNSKVRRFFWDPIFGEDAQGTLFACPKGMPTVEKPEIEATFAKAVPKARVAVVSKPKVLNLLPDSKRAYNMNIGLSKFSKYTFKELKDAVLGLDPAVLNIEATEGLMTLLPTPEEANIVQEYVKSGGDMNLVDRPEQFVAVISTIPLLKQRLDSHHVALTFKEHFQEIITPLERIMDGCEAVMSSIKLNVLSNVILKIGNTLNEGDAKKGNAEGFKPTTFAKLNEFRTTTKPVKTLLQYICDIVAKDDETMLEIYNELRPCEECSKIDTVALEANISKFKNDMQKVNNSIAAVERLRDANDEFVPIMRDFLKDAEPKVSYVQEQQKEVMLMFRETAKYMGYPDKEVEKVRVDELFRHIWGFAKNVEVARKARLEAIEKERRMVMAERRKQEQVAARKSKMRTSLMPTTVTATPKMVDGLADIVKTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D930</accession>
    <name>A0A061D930_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0309560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769239.1">
        <property type="nucleotide sequence ID" value="XM_012913785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D930"/>
    <dbReference type="STRING" id="5866.A0A061D930"/>
    <dbReference type="GeneID" id="24565594"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309560"/>
    <dbReference type="OMA" id="NYALYWA"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="28210" checksum="096E383C0DEDB7F3" modified="2014-09-03" version="1">MKLLALISGGKDGIYSIIAAQREGHEVVMLGHLSPKDGDQVHELDSFMYQTIGHNIVPAIAECMELPLIERQITGAPVVTESLEYAPKEGDEVEDLYRLVVDAMNERNDIEAILTGAIASQYQLQRVSNVANRLGLKTVQPLWGREQSELLAEMIENDMNAIIIKTCSMGLNEKHLGKSIRELYPEFLEIRDKYGFNVCGEGGEFESLVIDCPIYKKRIAITEHRHILHSPDPFAPTMLFVPVKWQLQPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C5</accession>
    <name>A0A061D9C5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769334.1">
        <property type="nucleotide sequence ID" value="XM_012913880.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D9C5"/>
    <dbReference type="GeneID" id="24565689"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310510"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1719"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1792" mass="194176" checksum="2CA500A9E61B2F05" modified="2014-09-03" version="1">MASAVGIKLTSLKECLIFLNWLYEREGKRKLDQVANKLHERLKPYYKDLDYRKIKSSLSTFMTTTDHFYKRLVKAHVPTQLHSNNNSMPRDPNVDQVVDALLECIPKFLAAMYYLWYDVNATFDNLGGGGWKNDYPGYEKHWYTGHYGGDLQKYLRSTNPNDYGGTIPGGFGENEVKYAEYYTGYYQGLHMALDLKSLLDKNSSKYNLFRDIFATSVVPASGNHKANTANVLALVKAFCQVVENDSDGSKLIKVVQKPETCINWPELKKHCTALRGKIDKLFTRRFFDHTGQSINPKHINAEKFAETTANWLRENLGTVRSKLERINTKDAAVNAPNSRNLGAYFTNNLFPYGFVFEANHHLWNGNNSKALLQRWREVIEMLSKDDEASGGLKKLIKLLNGDDCPAVTKTKATKPNVVTPSVEGGVKSAPKSAAKTPQTARPVVTKAEAAKPVATKTEAAKPVATKTEATKPVVNQEGTSRNQNSGRSDGKPTTSSVETSSSSLSSGSAGASGPTGTQGGKGQKGPGSTTSTTSTPKSTVTSQKTSSQQSSSPPQASLPSAPAAPGSPSKPGVTSKGSDGGGGPGQKSGGSSQPGQHQLPSVSPPRSPSSNASSPGQGQGKSGPADSSGFGTQGGQDQGSQGGDHKGQQPDSASSSVQSQAPGVQRSGAASSGASVPGQGSSTDADPKGGKGKGSPGGTLTTQQTVVTSPPGQRQAPSGTSQVTQSTGASGTGGGQGSASVPGKPGAKGQGANGGGNAGTQPGISAPPGQPPTTAVQSPASPQSPGVHPPTPPSSSAPAPGGSQGTSDQATTSGTTQQNDQSTSHTSTAATTTTSAGSGGGGGGQGQTFAATDAQTVINSPRSPQIHSFPPPEIDVIYGPQKISENLEEAYRKVLQKNMKSVPPNLSIEITKPPTSDTDNSKDAPLVVLHDPTEFGLGGAVASDEDEPVVLGVGGEPITSDSDVFKQQHIAEIQDVHQKLYEKQKAEDLELKKALEAGAKRQHQDTLWSENMDDVLRKEEETEEMRKNLQDDTLGEVVKIPFNTKICAPENIIQRAVHGFNTYPPPIIDIRAVDSKNIYSIPDGSNKLVNVPDPKQLPTLDIIRAYIPRSYDINPPNISQDEYNSAASPVLFDITKPTRPTDEDDDDKSFQHMDDVKSVLIGVNPAYEVIDDGLEISKVTHTDAEETVDLFIETLNTAPSQPLHDYDPENIPMIKVQADHTRDGLDDFSMGDADRSDINIPMAVFPDQSPDDLNTQTCQNPWYVTPSSTSPTSPPASRPPESDHLPPPRTVREMLYWFVGLNTYGYIGIIREHVYSFLKRFKNDAIDVTLEPYTLDASHVADKLTEACLYAAHVLFRIRYKGSSDAYETFFKDQDKYAYYYSPDPACLLCQLRDYAYACHHQLEFLKSQCERDKLSGGWQNCNYGSDPKKPSPLQAFLTDAYDSTFKTHLFDPCNLCLKSRVRMGFQRGDLPKTSQQGSVISSIITPSCGGEDPLLTLSSYLICLTRRTPRTTGELVSYFHNFGNEMHDAFSKSLLPLGSSLSTPHLDCPDWDHIDRIGLQAVRGIRGTESLNSISNHNHDKDHPRTLSTLVGCGSDPDNCHPHCSPITYRAYALYSQRFAHTYLSWTVYLPDRLRESLQKLHYALKKHVSIKCSYLHLCPDALPLLYLHGFTPPEVGSQQQLKCSDVIEKLQEIVNGGPIASLMTAMDNFLYGIREPFIFTLVALWSLALLICANTMLYRLDVLHIRSHLIRSKASHRMDVKALLTKGRKMLSLYKDVDYFDEDPIVQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K6</accession>
    <name>A0A061D9K6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor GTPase-activating factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0107140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766591.1">
        <property type="nucleotide sequence ID" value="XM_012911137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9K6"/>
    <dbReference type="STRING" id="5866.A0A061D9K6"/>
    <dbReference type="GeneID" id="24562946"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107140"/>
    <dbReference type="OMA" id="PWWEKGQ"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="392" mass="42354" checksum="1097981B86366409" modified="2014-09-03" version="1">MDGQNSMQQLQELLAMEGNGVCFDCGASGPSWVSLSHGSFICLSCSGVHRGFGLSVSFVKSVNMDTWSARQMLYMKHGGNQKLRSFFDEMKIMDLPLSLRYKTEGAAYYRKRLRALVDGAPLPPMIEAEVACRLEEQTPGSLSATPHAVISAPLSPSSSLATPFTQVNIDASDVTAEEDGASVPLHPTVPQINLQTSPSMNETPGYQPSQMPGRHSVPPGAQKKRSQKSDFLGSLGSMFGSFVDTAISTAGTAVTEMRNRGVIDQAKGAFETSKSWLETQGKKIATSVQDPEFWETSHLRAKHEASKVAHHLSTAASTAQSWIQKKVAEMQNSSDPAARYGGTESSSVSYKPQPRTQQGPIGVMGGANLWTEPKDPDADDVNPIIEQYQQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Y6</accession>
    <name>A0A061D9Y6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769712.1">
        <property type="nucleotide sequence ID" value="XM_012914258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Y6"/>
    <dbReference type="GeneID" id="24566067"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400180"/>
    <dbReference type="OMA" id="IVCYEFE"/>
    <dbReference type="OrthoDB" id="365167at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="782" mass="89149" checksum="86BD4B4EF12C9F0E" modified="2014-09-03" version="1">MPSHISWRSEGFPGYDSVSGHFHWNHLFRNGDSLFSVVSAWKCVLRMFHVRSRYDTGKEITLSLFDIIESSDDVGVLKQKYEQFKTSSRDFPDRTKGLVYDLFERIKFVGSFPLHKAILVREILVDVEKDVVEEALYHSMSSCSDTNQANSLILLHIVLKGEESDGTIPPIAALHDIYKEANVDPEKAIAEYKRALYKKEIDRVLGIQMEQRSKTDPPVPPPMARSATAQKNRRTELVRLFGHEILPEVTKADSSIDIASKTMLKPTWLAEFFNDARTYEPPTCGWSVLMLERAECYKLYNEVINGKLEEVKERILVKEGAPMDKNLQEMPKLAMLVHCRRQQICHICENITDWERIETDRIVRLKNIYSVDLTMRHGNFTPIHKPTIGGGKALPQPFYVNPEDDPNYDPPGSTPSSRLMNRMLRGDVKEEDKFVPTDLETRKKGLALVAKEMEPFEHLSPEQLSDLVLRNCKKEYELAEAIYRRRLRGRSVEDYHEIQLMTEGEHLDMPTSANINNQNGHKISKAHVSGNGIHSLREDYVITPNVLLTDCVVFLSMLEHLQWQFTSAVEMPVESLVNVHNMGDSITNPRPPQLLFVDPRCREAHGYTREYSASVSDAWAYRSHLNANVNGIDDSHNDGNVDKLLLFGDDPVFYLKDQEMLQHMTRHGVGLKIHSKVPGFTLPPEPTEHQKSTVFYRLNSSQPHVQQICSNCGYHVFSHTVKAHDGESLTSSEMDSLLDEDCPHCPICESQGCALSQVWVTGSRGYSPEPYPTPVEDEFCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA02</accession>
    <name>A0A061DA02_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767925.1">
        <property type="nucleotide sequence ID" value="XM_012912471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA02"/>
    <dbReference type="GeneID" id="24564280"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208930"/>
    <dbReference type="OMA" id="KNDITIM"/>
    <dbReference type="OrthoDB" id="10427521at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600187" evidence="1">
        <location>
            <begin position="24"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="736" mass="85006" checksum="F640A6B1C7EDD5B2" modified="2014-09-03" version="1">MIGISKCLCCYLALLFGIFTLRGCDVASGIPTGGTTEDESTQGPSTSSDPIDLTLRSLPSADFNQNVKHYLDSMREICIILGRLHGFDFRVSDHLATLKYIGEADSVGATVKNNTIVYAELENAYSIDAIVNRMKRRTWSLQFAYQKDRLADVQLSEATASMRATWIINIALQKHVDELSTAIKLLQYSTFKIQLMNTLGCADLNSLESKIFIRALTNQYMSSQPIERITAQEMRSKLAGIMQIVENDSGWTFFQTRILSDLAGNLCINRRMGYYGRFYDPMFCHYDEFRTGIWRWHRLYHALHVHKKQMKKASFAMQILYDWLSMEGMDPDTSQFYVKMGEVLDGAISQFIWSDREKAIFESELSELQPLFEHMVERKASVDAYPSLNAEVGVHKEYFVNNTFNRDPIYHLLMIHYYSELVYFDKCSRHLIVSMVVYARKIRQFPRLPSEDEESRRFKANRIYHQIEKLSGHAEAHMRKMHSIMQHAVASASLNQDTEETYRQCQQELENYLNGLGLTYTAIRSMIVDYLRLIWPSDTADYNMDLTALVRFALPYVVDLTLRAHRVAVANSALFDERTAKLKWNMNSMAKIPIASARTHESACYRDVDSRFGHILSRRLDLHSIFNHLHMSKDDKLYLEIIYESLAGATRASSNKKICKAFKMYLNKRELVQRALQQEIAMPRILELIDQFTNLVHTYRQSFPIITAAVRRCETITAQLESNERMIQNMNPNSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA54</accession>
    <name>A0A061DA54_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0313160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769599.1">
        <property type="nucleotide sequence ID" value="XM_012914145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA54"/>
    <dbReference type="STRING" id="5866.A0A061DA54"/>
    <dbReference type="GeneID" id="24565954"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313160"/>
    <dbReference type="OMA" id="YAFLGDM"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="284" mass="31142" checksum="41303B68B26DD51F" modified="2014-09-03" version="1">MTELTLGELKALRQREAKRPSPGEVGFQPVAHVIARQTEGHQADTTTHRERLDVMKSREKAPKTDNAAPKKSSGKGPAVLPNNTAFNPYTNIKFGSKGAGARLKARDPRFSDFSGTLNDDLFRKSYAFLGDMLQEEVREIKAAVRAGERSGANSLKATAALGGIAHMNIASISDAKRALDRYKTQQKQLQSDTELRALKKDLIEQEKQKIATTGKTPFYYSEKKIRKIHRAKEAEKERAALQSAAINAGAAGAIHKKVARTLKRKVPKKPKVHAKAAGKKPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA85</accession>
    <name>A0A061DA85_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell cycle control related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769812.1">
        <property type="nucleotide sequence ID" value="XM_012914358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA85"/>
    <dbReference type="STRING" id="5866.A0A061DA85"/>
    <dbReference type="GeneID" id="24566167"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401180"/>
    <dbReference type="OMA" id="DSYLANC"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="375" mass="41818" checksum="BEA2EEBE2CB66040" modified="2014-09-03" version="1">MSTLKAARADNFYYRPDGASWEEQRRRMRKTPKRPRNHFIGSTRSYAGDAGAADSTHVGADDEALEPFRRGSGRGPVIRFEMPFKVICLRCEAFIAKGVRFDAERKAVGNYFSTKIYSFLMSCQFCNNPIVIQTDPQNTDYLCKVGVRKKVETFDTADAKTLELGHDDATKQQLMSNPLFKLECMALEEEAAAKGGAAGEHVPPQTDHARTPMGDDGKRAGAKALVPASGVGRLNPRDAAIGSRDGTAAPIIDSKLDDLLRINEVNSGDWFIANSALRKKFREEKKSLKTIANFNLKLVDENEKDVQEARKITFLSQSSRIKAHFKRIIKKDSGIFSRTCASSTSGDSTIDDKRRRLQFIKHVDSKLRMSAKRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB3</accession>
    <name>A0A061DAB3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769098.1">
        <property type="nucleotide sequence ID" value="XM_012913644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAB3"/>
    <dbReference type="GeneID" id="24565453"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308160"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="66" mass="7195" checksum="5D2078F337524B5A" modified="2014-09-03" version="1">MAIHKVFIISGSHIFSHRNTSSYLRGNTLYDSAGASPPRVSSCLPSRSRTTTPSNTELTFGNSYCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAF9</accession>
    <name>A0A061DAF9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769872.1">
        <property type="nucleotide sequence ID" value="XM_012914418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAF9"/>
    <dbReference type="STRING" id="5866.A0A061DAF9"/>
    <dbReference type="GeneID" id="24566227"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401770"/>
    <dbReference type="OMA" id="MYFQCGR"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="220"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="507" mass="54409" checksum="7C6E88F14B0F8F15" modified="2014-09-03" version="1">MRILRVFRHLAARAGACVACRVGIEARTGCDGDVTGARQPRGRIRLWGEIAALPGGKENHALFEDASRWRCVTFGPSFGAAIDDTGAVYVWGQMEDGRFVEPQALEGAGIVDCRCSATDLYMLGADGNVYVLRDISHALRERSETSGNRVQSSNVESGDEGATGASGHGSGTVARPQHAGEQAVDKASLPTPERVQGLSGKRIVKMSVGNAHAAFLADDGSLYCSGDNSFGQCGTKPSNVSIDLTFMWLPRSGAVPQELIGVRKVEFKDPTTSIVDVVCGGRHTCCVDSWGNVYTFGDDSSVQLFLGDTRGRTLLEHEQYRPFASPSRKANRSYTTYTQTDRHLQFNPIPVTRVGKLSEYMHLIRGAPATLAAGDDFTVVAATPEAQGSDRATHLIASGDNRFCQCTGVDVRMIRPRVTRLSGVLLPHSLGCGSSHCMAALTNGQILGWGSNKHRQFGPNKRTVLTAPTAILPPEHTDEGGASEPLPPETIQFMRCSFNNTAIITNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAT9</accession>
    <name>A0A061DAT9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769859.1">
        <property type="nucleotide sequence ID" value="XM_012914405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAT9"/>
    <dbReference type="GeneID" id="24566214"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401650"/>
    <dbReference type="OMA" id="WVTPHEL"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="123" mass="14038" checksum="D257C89C92099BB6" modified="2014-09-03" version="1">MVVPLLRTDAASQWCPFHALNVQILQLLLNEGFIRGYSVHGDRINILLKHYKGAPVIRNVRVISKPSRDIWVTPHELKSRTRFNTGLWVLQTSCGVVSHRDCIRMGIGGKMLFAVNNNYQHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAU4</accession>
    <name>A0A061DAU4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPTG10-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767006.1">
        <property type="nucleotide sequence ID" value="XM_012911552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAU4"/>
    <dbReference type="STRING" id="5866.A0A061DAU4"/>
    <dbReference type="GeneID" id="24563361"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111180"/>
    <dbReference type="OMA" id="DTKMNMM"/>
    <dbReference type="OrthoDB" id="363836at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049262">
        <property type="entry name" value="ATPTG10-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20716">
        <property type="entry name" value="ATPTG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPTG10-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="120" mass="13615" checksum="E8A8D6D6A4B62B78" modified="2014-09-03" version="1">MEPGKPASGNASASPGTYVDNVMSDIENLNRFAGASLVNDRKTMMECFNRFSWRDARVLSHMERYCAADHAERQLIDDVYRVLCPSFDRVQGPSFAAMSLWLKARLHLQHQTSPFSPVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB03</accession>
    <name>A0A061DB03_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768285.1">
        <property type="nucleotide sequence ID" value="XM_012912831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564640"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300040"/>
    <dbReference type="OrthoDB" id="10507020at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1424"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1486" mass="166291" checksum="95B1EC09D93D3546" modified="2014-09-03" version="1">MTMKTYKNTMIICLTYLKKIQQAKYNRKTHFDKNIRLVAQGITAWVRLVERKHETVTRPLNQLRARINGHMFVNLHDKPITDQLSNWQGFAGDYLGDVQNTEKALNNIDDYLGTMISPKIEAIRQFVLNFWMSVSNDGVATSVKSLHNKFHHQRIEVSTHISTQIQEVQKALNENFVNIQGRITRLRQENEKHIQIIREAVAEAKKLADALVVERGIYDEIYKTKIADKFTAIRDNIKKFAEDNNPKSQLWTHFETVQNKVRELESELQGDLHRLHGDVEGLYDLVDESIGNSLTKNPLQELEEAMANLSSGIIEPITQTSQSVKDQYDTELKNTFDNLKHGFTSFKKVIYGEKGNYANPDPDSFGKHITDLTAAICGSARGVEDGLDGLVSAFKDHAKKQIKIATKTAIRTALEQFKMDDDGTNIKVADMMMTFEICRKELDGAVTKVQRELTLLKNVPAFVSEMSGKADAEMEILRAEIKSIKQAIYAIDKPIKDAEEAFKFACLSLEGSLNSAKSASDVILPLLTNGLQQRVSHALDDLENAVQKKYNAQKKAELHALQTSLSDQITSIGSIIDTDMDTGLKGMMGKLKDTFDEHPLSSDNTKLNPYATKTRTFYDKFLTSLQSQPDLSPDRLTPLTQALYALLSTMNTQRHFDATVSRKLADLQTQLDTLAPSGFAEASPLLNVVKRGVQAFHGELAKQYVSRYSGQNYAGQLVKEKTSPDTKAPKLLANPADNTEITEYGRKCAKVFLTSLATLSNDFKHLSDSCKESRFNQIHTSYNKYNNKLGDLFSSCGYQVSMYRDSHEGELRNKPDFTGTDIHAIIHKKIFNVSSIDLLKQWMTKKNKASSVASIDADNMSLLDILQFLYDCLENYYCVSHLRHIERPKSPSSVYQMLCWLTGLPHNRVFPTVSVSDIGDLFEKPDEASGDSNPDGPLVLQTDPDTLPAYPEKIAASTLTSIIHKVCVDAEDVLIGILGHGHADGIYAVDFNTNPDGFAYPTAPGACFDMLCDVLNRLYLQLFFLYGQCSNEEPSVSWRDCWYGNQVGGSAWNCNAMQCPNQKGNQIHKQRCNQKCDQTAQCGIKSPLQSFLEDGLPGFLPHSFTKPGCKLTCTLSNHRGIPCRTPMGFNDISVTASHRQRGEYLKKALEGFCGSDSAPLTKLCAQLTCLLQKPPQTLGDIFAFYYGYLGGWAADFYGNFGKSNPHTQAAFGEAVNDAYFGEQYDDLNPITLVSSSKHSAEHSKGNLCSVANCESGSVAPCGLYVKSMTQDITKYYSAEHRANHLSWIVYITETFCDLLKKLYDDCCKKCGPGGSKCHVKSCVGQCTVKYTDSTGKPATPSENAHHTTNCKSIVTCRDTHPTLYRYGFTFGHPWGLNGSGNNEGAKRTCRDFCEALKKMLGEESVLIELRHKIDKFLWDIREKFSFTVLALWLLSLFYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLGKMFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB15</accession>
    <name>A0A061DB15_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767101.1">
        <property type="nucleotide sequence ID" value="XM_012911647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB15"/>
    <dbReference type="GeneID" id="24563456"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200720"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="320" mass="35110" checksum="438C36A6784718E7" modified="2014-09-03" version="1">MVYNSLTDAPRNLKEGIDWLLALKGTDAENNLAAMGAALYDFLVDKPVGYTEVPALEKVKLVSKEFLKQPELKKQLSVGHMLAKFNKPINKKATFLQKLFGGVDKCNYMNVVKETPLSAQTIAQKLGTAINGFEKFLEKITTADKYESAYGSEATWEASCSKKPEDCAAVFVGIAPMIWAGIRSLENACFDDDYSWPGLRNKKNVSAKVLSALGFKDSECLHNTSAVYVASAVAIVWKELLTFYDLSGFWAFYDCTKACSVTAEPSVEPVKPEVDVEKPVQIAKAAKVASAVKAAKKAAKKVSKKARQKKQKKKQVSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB60</accession>
    <name>A0A061DB60_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein disulfide-isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0402610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769959.1">
        <property type="nucleotide sequence ID" value="XM_012914505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB60"/>
    <dbReference type="STRING" id="5866.A0A061DB60"/>
    <dbReference type="GeneID" id="24566314"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402610"/>
    <dbReference type="OMA" id="VRAFVIN"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF219">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595642" evidence="2">
        <location>
            <begin position="28"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="388"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="531" mass="61078" checksum="659D7D3B58E94291" modified="2014-09-03" version="1">MNRPVSALLAVAGCIVASVNFVQPVVADLYVPDPPLAEQLTEETYEQFLRSTDKTAIVFSYPSAAVFGPGSTVEIAVVSKILEGNSMCKFGMYQVNLTLSSPVEAMKTSLSYMKDGQLITMPTEPKRVTDIMAWITQQRICEMRLPSVESSRYYLRAIESGHVNTLLFMGEGHHDPELEKKVYDTLLSTGLKSPFMVADRDDIIQYIYRLHTLSEDTMKPVGVMVTRNNLTQHPIKIYWKDLHDVEALTKFFFRELIPPVHGTHSYMLDSVLATNKTMVYIYTKEELIEYVIDVNWLNKFARKHSDRFVFIHSKGDEAVEKRLNQLLIIDSDYVDTAVRAFELHPERGEFVKYKPIDMQDGVITQVKLMNFVNDLRNGKIRHFVKSELAVPENIDVGHVKTIVGEDFHRRVIESDVDVLIVFFSPWCGHCHHAKRVFRDLGRRLKKDKSVMIAKFDAFNNEVEHMSFTEYPTIMLFPHGAKDDPIRYTGDISLQSLALFLENECKKRYINAAEVLQREVHQERLFEEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ1</accession>
    <name>A0A061DBJ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770104.1">
        <property type="nucleotide sequence ID" value="XM_012914650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566459"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404060"/>
    <dbReference type="OMA" id="AHEYNDE"/>
    <dbReference type="OrthoDB" id="364829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2022" mass="231656" checksum="D6162D30E21E660C" modified="2014-09-03" version="1">MTNFRHCRTIGGISAGFLLVTIAIITGYLMIHPSFWIHVQPPVKVSEVFTFASKEQPTTITKKPVVLDRIIRPKHYAIDIINQRPGYVTLYRIRNSFKDTHYINQLIHRNINVTINPPEATEGLPNDGIMYVRYQKCDCCSMISVHYRKQGKVHFEEYIRRNAEMAYVNSREAKQHFHGELVHMDTLMLETRLIAKMMMQSATGVSLVTPTHHVQVSVPRAPGERNTTVITWKFEYSIPDERLTDVVYVDFEVHGDAFSLPNTTRDVFVKKAAYKDGAYGLVAAEGEEFEHLHRTKYLFLYDERHHILRHLFVVDKQNPNIAKVYLVVYNELVSVVSCVVVEALFKKGAWAVGSSIVERYDLPSTGFLSAQVVLPQVGKLRPRLYPQDFKFAHEYNDEQTYYVDKIQIDNRHRPDHRVPTWEIETRINAKVDSAHELKTSAPLNTDPITLALGQNVPPEVTQVTLVPDNTIHYYTVAEEYRHENRFKRVACEDFRYTLYENDVEMEQSPDYITGVTHYTLPGWKKIDIEFSREGRPHFEQYLKTEEAYGFTQTLGAMMPGQDRPYLLDNVMYKGILVLKLMLQNDKGLSLIDHNVSPSIVVHLNGNQHSWSMTYLVPIVIPNVDFYHRLQLKLTCENNVIKVEPAKELAFRVSSGPQGAVLKTAEIDPSMAPHVSATSEKHDRIIQHIMVHEQDDEDKLLLYTFIYDQERAALICTVRPFVSIYGVWQAGHQDYSFRVDPATGTKVSATDTFQYPCVNYHPVTLVIPDVNSMPAVYPQEAGRVRRVKQTNIFTINLLKDGKFAISDIRFTDLLWIHMSGMPKTAIELNLQQPIQHEIKSMQWRNGETKYYAVKTDFGPTHYIETLVYNGLYYKMDEEEQDHGETTAINSVRVVNNGKEETVHIKYMKSGVPKLTCFYRQLPDGVFVEQIGCKQLQEDLPTMITSVLYGDRLAVNVTLENEKGQSLLDPSRRPSILAFVGDEQNHPKLRLALPIKLPDLEVKDLIDIAFVVTNGKFVHENIPGKSNGRVVRYDEQGKPYIAPAVGEHFRTLVGTHMRKLLWEKLILLKVIVVPHKDEVKHADVYSFIYWPMNSTVFANVQSATLQRGRWLLKPVPVDRFHVPAANVAHVAFFMPANHTVEPVLYPESGGIVRELSAKNYYAVNLNRDGKYSEIDVQGDAIPVVKIDDMPRAAVILDLVQPLPPEIQVVFTSHRTQYYDVKWQFRHTHFISEIAYKGLRFKVTTDEGTLYRPEDAIMDVELIRRGEEEYVNLQYIRGGGNRYMKYFKADDASEFKLIDYPSRAADSPPYGLDYITYSGALAFRSNLQSLDGTSLIDETESAALLMHRGIGIQTSFRVVLPIKYPGSDVKDRLHLSFHSHRGRLVLHNFENANVAYNALSLDNATERFLPATAPAFSDISDIKTVTFDGRIHRVIQGTVVPVRGERDKAVIYFFLYDFLKTVLYCVTTETKMVDGVYQYTGVVKQKFIYPVKNISKVHLNIPLDRTESCAVHPEDATTIVELTPHWYALSFAKVENPDDYRLHPYDAAFIGASGMPRLPIILQLNELRQREEIQVINLSQPQGLYYNVHPTFTPTHLITGIHGYELEGMELGEEDGDAPPPTEIFYVHKTSVASWERLSIYGKVGKAYYFKEYLKNDYQYLPVRGSIVPATDVPYMFTTLLYHDRVALRVHLQSMQGTSLIDPSEYPTVAVYVGEGVESGMLFFAIPIRYPKTTVRDRLQMKFVIGYDNMEYEPHWKRGPKNETVVYGHNGNYTIEHRRFTEYAEYLNYNGGIRDKNAQQYVIKSVLVPERAKTPSKAHVYTFMIDNVTRILTCRSSIANMVDGIWKITPATDVDYAYPSSALGSAILDVMPDGFTAAPILYPNEAGEVKVVDDHLYVVRQNNTHVHLVSDVHPMDVNKLRSHSFPIMPIDLDLEDEMPEEVAVEIGEMRDAFVYKVKDTFALSHFIRRLKYRELDTLIQTREEAMQNIANKLSVIKESNETHEFVYVVLPNEKRRIAELPLRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ7</accession>
    <name>A0A061DBJ7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770272.1">
        <property type="nucleotide sequence ID" value="XM_012914818.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBJ7"/>
    <dbReference type="GeneID" id="24566627"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405700"/>
    <dbReference type="OMA" id="THPTCLH"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11599">
        <property type="entry name" value="HDAC_classII_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF26">
        <property type="entry name" value="HISTONE DEACETYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1748" mass="194642" checksum="C87F0A4A27F5F1F8" modified="2014-09-03" version="1">MIPIEMDLGYRLMADENEDVPIFRAEIKPLIPERRATPGIHKCVMKNDFDALKRILASRRRESINDCDHFGRTPLHIAMQMANPKALYLLLYYPLVHHSKVFATQDWDHLLGHLGDRQSDDWDVDIAMGLDEKCDKMELDDSLHDTNTESTGPQSTRLAKDTGVDKFKAPSSGIRRKKVEWSQNEQCSNVNGTKIDGSWKMDTRLLRHWEDSPSSYNKSVFGFDRGSTIFGCGTKEVEALYEEHYKFLVGEPHNLEVAARNYSAIYAGLYASHPANLSHVMASMGEGVPNIHTTITFERSHANDRKSVAVTTHLADSYPCGAPDDVEQNDDAQEMKEHNTERSTGKGVDNRDSNAITGYSNSAQHSHSSLRPHLRDMVNATLTRRDCLPVPLATTDLLFTYDKTSPIHLLFSNIYIESYRNNIIKCFRILLHYFGKFSESTEGSGSHEGSLGEASSEENEVSETPIVPGTPTASSTELAAIERNTPQKHPENSEPSTHKRLNLTSCGVPSSSRNAFNGADTDEAVENHFKKAKTCKDTNSGSRGDGSTRNTVRMDTGESDGAVGNLIGKSQLSAVPTVTDTSKRVEYTKTAHATEYESSQWDSVDAVVTIDAVSECAVPLNEQKENLVPCSGNPTPIRDLVNRPNVTPNNFKGHPGINQTLCADVSEVDVDAMASTFKGIGDIRRGRRMIRHKNCSQIAVKPSEFPLVSKYVLGGHMDYKMQALNDIVCSSSLLTPTMPWETFLNQRDYTRSNLLHKVCQIRDADLIKWLIGCGCMPLVVNEVGDLPVHLAMDAKDPLCLVTMLHETLKALFYHKRYMTESKRNNEEGAHFLQDDQRNLCRRGLSFESFMKSIKFYKRSEGCETSVVVEAAQATSIMRASVDEKCHPRSEAPHVPINEASLLCTGEYGLLRDVEYFAIFEEMMKLIEQLTYRGIKAGAWEAIVAMYSYNEGLTFHVLASPQYMHRFIKLSIMIGNSKHFMDVASFIATTLVKADATESSVKSLESGYSTHGKTLNNVENVCNGAEAVGKVEVVPRSQKHVQSTNTTAVGRYKGCAFPSLSLKRAINSITMSVTDDPALYVTCPEATVTRRDVDSLLQNFRGHVPNQDTIADNKYTWVITHPTCLHHLALPEPTDAPNRRHRLIMSYPENPTRLEVIITNENGILRSDTLEHIKLLHSPPPATLADILRVHDWGYIDKLLNQVQTAQKRWMGNNYWPVLADGDTPATPHSWNSAMYAAGSVIAAVDAVCNGHCRNAFCAVRPPGHHLGTWGGAQSADFEDEDFAAGSQGFCLINNVAVGAAYAKYMYAKKGIRKIAIIDFDIHHGNGTHQIVLNIGPRNVRCRHGNNGVGNDSKASQYNHPHWFGWRDAHDREEVFFSSIHAYDGVFYPGTGRTCSKYKSSEPRIINVGIPEGTTSAEFKILFEGKILPYLLHFQPDLIFISAGFDGHYRDSVSSGFVRYNEKDFYWATERLVAVANTVCSGRVVSVLEGGYNTRLDTLSPFAKSVFEHVKALSNTHEGFVYPFMHSHRTVDMLLLPMLDDKSITPPQLTKSDADNLSIQRAMSKSAFITKATDQLLRKAYGMPRIKCTNGPPLFMTTPTHIMGLEAVAQTGNAFYSFYSKHFHSLFMADTYLGSREYVLSVLHNIPAIGHDVFTFDKCLGIRPLGNNAGGSLFSYSDESVTMSKIASAFIMQVANAGNDGRMDQRFTSNAWAMGIKMKSLERHATAAALLCGFFQKFEYLFKCECKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU5</accession>
    <name>A0A061DBU5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY C MEMBER 2 (SMARCC2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768535.1">
        <property type="nucleotide sequence ID" value="XM_012913081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBU5"/>
    <dbReference type="STRING" id="5866.A0A061DBU5"/>
    <dbReference type="GeneID" id="24564890"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302530"/>
    <dbReference type="OMA" id="CHAEARY"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="301" mass="33894" checksum="FD8DD010D3DF70A1" modified="2014-09-03" version="1">MPVGAKWSKHPFVPSKWNRSRREKLYNAIDKFGMDWRMVQEELGDEVTVRECIYHFVMAPLERETRGIVRLPVCFSHIVDGKTDLPFFTSPNTVTAFLAFCASTISPVVASQAAKTILNDVMKPEAWPPGYAKFEADESIQRRDTKSAATTEATCHTTVTPLRNDRKDADAANANKLHGFTSNEHEVKGGKQAEASGTVVAQDKDAEHDARPNPTVPDTTLFTAFEQALQVSTETCARLAAMEQQKIDAVLARIIDLKIKNLEEKMKYHAGSEEHMDNCRIQLVRYSSLQLTWCRGMNYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBV7</accession>
    <name>A0A061DBV7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0203930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767421.1">
        <property type="nucleotide sequence ID" value="XM_012911967.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBV7"/>
    <dbReference type="GeneID" id="24563776"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203930"/>
    <dbReference type="OMA" id="MAHEEYN"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1651"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1439"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="725"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1677" mass="181781" checksum="A6BC8DE5700B2E48" modified="2014-09-03" version="1">MPRYSVSCTVHEALLPQQPGGTPVDPLVVMRCFGSERVTTVKSGKTTVACWDESFNWSNFELSQSAWNVGVLEFELQAANAFWRNSTLGMGALQLRLVCATRDGSYVGQLPLTAPNSVRVIGKLSVTVNVCDSLRIGGIAAPVPLQTAAEEPSTNDRPSLHVPPLLSPAVYRSAILDMAHEEYNYYHLYINVYTLEHVEVGVFAGSPSVTVEYGGCRLQSTKPIRSRCEGSSSGGVGVGVGVGVAGILSGFFSASGDSGLRDRSNFAFNQCFLVPIRTAVGKSILEDNIVVRVWMGMEINASITAADRPPLAPKLLAEGVFSLAKLRSRRQRPRWFNFYAGAAGAKRREELRKAHVGKSARNDAAGDPAFGNKGSGAGGEVHRSAGSIGSASTCDSLADGAPGGSDIAFGELEDHYIGRMLMSASVKRLAKPSDVLVAHVQACHPLESPVVNPTRLFGDAYCIESRCTFGFEGDFEIMLEISCGPYETSSEWLPAQRRLGGGGTYADELGIFGIKSAADDGLRRRVSRSGWRVTLNSMNGRLAPIDLLVSHTAEEQWVVFVRINARGTVAGRTQHRVIGCASFPFDQIPEHSSKLQAMPLWIPLCCPGSTSTIPSADPSAGFTDPTGIVDAVSSLNAEHIIDKAVALDPTGLIGVAANEVLGRQGTLAGTDLGAAAAARGGGAPPSGNSRHVDILNSFDSEIEGRNAPRKGAPSHNNAMEQWIASRRPSQDKNRSTSEAGPAKQKMRPDERNQALKTAPAGSRRTGASRPTSTSVQPGAAEPTDDANGPTRGDMCDPGATVNVLMTLHKHSFYTSMSRSVGVGNDIRTSSRPRMVSMLRQDYELRCYVYCAQLSTAPHSGVAVMVSCDCGSVVTRVQRNFTRFPVFSECCVIPVAAPTLTSSRMVPPPPVTVSLMFFDSRRKLLRVESAITVYNRLVRSASGHAQARDSATPTWLHLSGGSRVAVFTELVASEDAPKVPKRPMAHLTTRCTVALGLMGLRQLMVGAMHPLDGLLLRLSSQSYGVNVECEQVFERQCPLGQSKWERGGRLNVDLFTVLEGSFHIPIDQFFDPHVEFYCYAMYGGAVGRLIGYHSFRCHAPSGGAAADVDLPMALDMRCALVPRRMTRLLDDLALRSSHDVLTLQDSCPQDGATRPLDGVPPVICDFESSRAYARLLRSMTFERVGMQVPPRFVVACDGKEAEAGATSTSVGGAAEYLDAVLRDIPFTVKSIHPVPPVGARVIDGKAAHQDCMDNVTMKYFLTVRHAGEEQVQRSYPEALSGVATSASKMLRVFRGGLRNSLHKLRFCVVAAINTVPDCDALGSLSLLVEIGKSESREPLSCDRSAISKEVHRTWEQEIFLPEDSVIRLRVVNSFERLDSSLEDELIASAQIDLENRWYSKAWQRMLRNDLVPVERVLLRDRNNNVHGSLDVIVQLGPIELFSTLRPLSFAKSSPSVAELRVVVWSTSGVRLAATPEDARKKDQLDLYVVSTLDCQGYRGECALEQRTDIHYNCDSGSSQFNWRLVYPQIHSPVGACQLQLAVFDFWKVGPPTFVGEATLELRRYVEIVSATSTRVELSGNLPLVHSSSSRPVGTVKVTVQVMTQAEASCSPVGLGRGQPNCKPFLPTPREGRQWNDWFAHTSLGFDFGVLSLYVNAAICVLLAVWLFIIGFVYPALLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW2</accession>
    <name>A0A061DBW2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768560.1">
        <property type="nucleotide sequence ID" value="XM_012913106.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBW2"/>
    <dbReference type="GeneID" id="24564915"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302780"/>
    <dbReference type="OMA" id="TANFLEC"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="166"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1330" mass="149218" checksum="5406668C1190565C" modified="2014-09-03" version="1">MSSPGTSQTDQEGFVTMDSDSDMFPAAESTAGMRSPPPRAFDKTRDAICFPHRLKESLQQKAVADDLYSLNLNIGKAECTIKASNARCFGSDARTCVMGANKSSAGADNESYVEENTERSLDTAVPVEDSVAGGQEVTIDRDHCFGAFASNDVNVDAPSTLRRFVSHMDLRITDYFTQAQCYGSYVLYSLHFNDFGVERVVTRRYSSMCYYDCKLREAGYTPPVSLPEKRFWGNTEARFLSQRYQGLKIYFSQQLRYPSYVQLSLLYMYLGCDKESLLYLNLVTARTREKKLTALTLLFRYIMMSSAERVAFLKRVVPAYHTCFKHFSAAADDDAYMDDIPADYRLSHPSVVASLLECLASNDAKAVCEVCGILLWMLQREDIFRYSVLKVETIAHVTKAVSRLLVSNKMVDLDLPIDRFRNPLGIRLLASDQGAIATVWNIVSYFVVNSVNLLPEAAIKFLDNSSIEKLIDLVDRSDHGVTRCIALWLLWIGMCDDHVNHSVDRDALGLLLKKLYGSTETTLRVMCGLLLVSLISGGWFRDDEKPRATVYVLNLLPSSHGLDAFVCQQIFAHHSVKLFAALLGDLSLCSGTRLFLVSVLLQHLTFGFEPSQQTASLSQLCDVDYGENVFRLSHALFGEDDPDYRGDLRANKDMTFGEKFASLYSLKYGALTADISDTLYSIIGHPPADGMTHLVDSGDSDYSQRLCQSTAFCLLLLPFSCVPKEDGDYFAVDFDPQSARAYYRNVVTFAGGSVRLTLDSADHINLEDRVLLRLDDEFFRRRVSVLRIMLSTLDASVSELDGINASGNETTSECMELLRSLWHCRRVVEQKENPDIVVSFDARGSDQCDLFNNFYFDGASGPAFEGSDLFRTVDALELCSYASELVQYSSVQQLLLRSVKRVLLYHQACTSRVDVYRSMVACLQRRTDELGLDTLTDLSDLEEKFLEVYQAYSLGVQEERDLAASIEEKNGAFLRIHSMLRSAQLKVDVCRRQMRSTQARIDDIPRLRDDGLANQGRLALRSEQLMESIRAVNSSILELQGEVARVEREKLELGGCIQQLTELSSVLDKGIYSDIIYVIDSVNHESVRSKLRGSLEAVVPEHVADGFLDADTVHRLKAEVLQRLTEVQERLSALCESDASIQIAKLNSQVSAYEDSLYRTNADLQSARKSMVTDGSSLEESLATQKRLLGSLESTVGYLSGELSNIQVIKSKLDKDLAKVKSCNEVARSALERRKATFLSGIKEQRKARMRLFQDLLGAEFLCKKLCQERCKLARALSHKPHLLEPLRERRGSEHFKRQRLIETLKLAAKRLEETANFLECPDTAAGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC40</accession>
    <name>A0A061DC40_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytidylyltransferase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0304030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768685.1">
        <property type="nucleotide sequence ID" value="XM_012913231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC40"/>
    <dbReference type="STRING" id="5866.A0A061DC40"/>
    <dbReference type="GeneID" id="24565040"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304030"/>
    <dbReference type="OMA" id="IDEIWVV"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39321">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39321:SF3">
        <property type="entry name" value="PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="8">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="210" mass="24258" checksum="7E6B6D6EADD6ED9E" modified="2014-09-03" version="1">MSLKVLLFAGTFDPITAAHLLMLRQAAETEFFDKIWILPSGKRTDKVFTASDEVRFRQCEIAAGQLEGIHPDVEVCDYEIKKGENIDSYFTMRYFQETYPDYDFYFFVGSDLLPQIVKWPYGDELVKITKFLIAYREGYPILQEDLDTLKQYKLLSDLLRCKGRSMEASSTSSTLVRSQLAANVKCDEVGTLHPEIMDYITQHGLYKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC48</accession>
    <name>A0A061DC48_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0204830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767511.1">
        <property type="nucleotide sequence ID" value="XM_012912057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC48"/>
    <dbReference type="STRING" id="5866.A0A061DC48"/>
    <dbReference type="GeneID" id="24563866"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204830"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="142"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="346"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="535" mass="59101" checksum="A20FAC7971C198C1" modified="2014-09-03" version="1">MSSAPYYTSDSRSSYGGGSSRGYGGGASRGYGSGHSGYRGFGGSSHGYDNSGLGSKLETIDWSKETLVPFEKNFYNEHDEVKSMSPADVDRIRKEKEITIIAGKDVPKPVTSFEHTSFPDYIIKAIAAAGFTSPTPIQIQGWPIALSGRDVIGIAETGSGKTLAFLLPAVVHINAQHLLRPGDGPIVLVLAPTRELVEQIRQQCTQFGASSRIKSSVAYGGVPKRQQSYELRRGVEILLACPGRLIDFLESGVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLAHDLCREEPVHINIGSLDLKTCHNVSQEVYVIDEHEKRAQLKKILTKISEGTKVLIFADTKKTADSLTRELRLDGWPALSIHGDKKQEERNWVLNEFKSGKHPIMVATDVASRGLDVRDVKVVINFDFPNQIEDYVHRIGRTGRGGNKGASYTFLTPDKGRIARELVKLMREANQTISPELSKLANERYGGGGDNRRWGGYGGGNYGYGGRYGGGYHSTSNAMPMGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC52</accession>
    <name>A0A061DC52_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0204930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767521.1">
        <property type="nucleotide sequence ID" value="XM_012912067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC52"/>
    <dbReference type="STRING" id="5866.A0A061DC52"/>
    <dbReference type="GeneID" id="24563876"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204930"/>
    <dbReference type="OMA" id="GNIEYIM"/>
    <dbReference type="OrthoDB" id="377772at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="403" mass="44520" checksum="E5031165235B9D78" modified="2014-09-03" version="1">MTNHAYASDNVGVIADPNIFPMMFAGPLGPSCAHFHGIPTPFLPVAPNTIVNPYQINFGDCRNSSQGWKDKGGQRRAVTSSYRKNVPDARVHRGRPYRPPGATALRAALFIEYAKSDFHLVESDLEELFSHFGGASKIDVKNDVAAAEVTLADGAAGRAAIEELNGLNIPNVGILRCVELHGGETLDRALSKAQLFEQRQSAKPYNAPRGADARVTHTNAASDTKCKRVARLELIELFTYEPEFNVTATILGPNNNNIKFIMRNSGGNVDIAITGKPLNSAPVCERLHISVSSRDYPAYLKALDMLEDLLTTVCEKFVEFVRSRGKVVSNLVGFKRHEYQEINGNLEYKGVTEKWKSWLNKRCNASPYKTNNVNRPPSKRVNDRSRGISRTPPVPKSNMRSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR5</accession>
    <name>A0A061DCR5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0404450</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770143.1">
        <property type="nucleotide sequence ID" value="XM_012914689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR5"/>
    <dbReference type="STRING" id="5866.A0A061DCR5"/>
    <dbReference type="GeneID" id="24566498"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404450"/>
    <dbReference type="OMA" id="GIEHACM"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000060">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="133"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="650"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="724"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="813" mass="92276" checksum="280320C21F5A7818" modified="2014-09-03" version="1">MLSNKTTMPLIDAAVVRNSFNSLSGFSLLLLVILSHLCGVCSWKLRHEPGRSAEKRVLRHFGAGGETQTPQPGRRRSSLDIVQLETKWQRYWEENGVFKAEEPEDLLCNRGVSTESPKAGEGRRRDSGGVEGKPKFYGLCMIPYPSGEGLHVGHLLGYTILDVICRYKRMRGYRVLCPIGWDSFGLPAERHAEIVKRDVREVTDANIHTFKRQIKRMGFAYDWSRELRTSEPSYYKWTQWMFLQFYKRGIAYRSTQTVNWCPELNTVLANEEVKNGLSARGGFPVYRKQAPQWLLGITKYAKRLVEGLDSLEWPQSIVAAQKKWIGLEHGYKIKFEINGNSPFGNALFGFETDMNRIKCIERLEVTTDMPNLFDFVHPSATEQVKQLVDNAARMSNIERHENKAIVSTGLEVRNPVTGCPIKVYVTNAPLLFTQPINCRIVTRNVDLVEDKSPSSDDTDDYVTETALIGTDGTSAYSAYVEPFVNLKLKDWIFSRQRYWGEPIPLKRCEGEYVPVNENELPVESGTQHYETMPQWAGTSWHYLRFCDPSNADEPYKQSAASYWMPVDLYVGGVEHAVSHLLYARFWNKVLFDMGLSPVEEPFEKILLHGIVRNASFTLDGHPVGEQDVIKHKGVYVLKGDRTKKVDVKLEKMSKSKGNAVSPDPIIDSYGADALRLHLLFLGPVAKDRVWSEKGLLGVSKLLDRIYNFFTKITITEDEQSVDGSLKQLVEKITLDIENYNFNVAVSDFFKFIPDMPKLAKCGELGRNVANIYLKLLAPFAPHVAEELWHLVNTNAAHSISHASWPISTNTSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCT8</accession>
    <name>A0A061DCT8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0404820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770183.1">
        <property type="nucleotide sequence ID" value="XM_012914729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCT8"/>
    <dbReference type="STRING" id="5866.A0A061DCT8"/>
    <dbReference type="GeneID" id="24566538"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404820"/>
    <dbReference type="OMA" id="VHFTTRI"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000002">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="13"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="168" mass="19019" checksum="03277F74FDC3E52E" modified="2014-09-03" version="1">MALKRIHKVTILRSVTHGTQELADLTKDPPTNCSAGPVGDDMFHWQATIMGPHNSLYQNGVYFLNIHFPSDYPFKPPKGLWETEGLRVAFTTKVYHPNINNNGAICLDILKDQWSPALTISKVLLSISSLLTDPNPDDPLVPEIAQLYKQNRKLYESTVREWVQKYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCU3</accession>
    <name>A0A061DCU3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ThiF family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0307930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769075.1">
        <property type="nucleotide sequence ID" value="XM_012913621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCU3"/>
    <dbReference type="STRING" id="5866.A0A061DCU3"/>
    <dbReference type="GeneID" id="24565430"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307930"/>
    <dbReference type="OMA" id="FLHIIAR"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="4">
        <location>
            <begin position="500"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1118" mass="123955" checksum="A655163F1B0332E6" modified="2014-09-03" version="1">MILFPPVVRRVDNVTAPPTLLSLTLRLWVATAVISAVHAGRWNRRPFEKQLSAHFGGGRLCSINHRSCKDVPAAPGCPPRQLEQIKQNDGYNSRFSRVSMVVSDEGVESLRQSRVLLVGASKVSSEIITHLLRSGVGAVEIWDAESGRSKDVVSQALLLQPDANLKLLEKEPDYDKLCHHAVIFVDQSVHKAIEVNKVARNKKKFIYVTSIGVYGLVLSDFGDQHRVQATSDMQNAEHQATLSTGGEHSAIDVSADKDILQYAPGDIIRISLPKYLMHDNEGDAIDTDRLIIDTQVLKVEPISDQAIKIFINADTRGWPKCGFYVRKLHTPTTFRFVALGNLVKGLFGTKPGLWESFLRLFRENTISPARLVIAPAEENAFNEKVAAVAAALMAAQGSRTQPTGDNEEVNDTWFAESCKMLYPNVDERVIKTFSTLRHIEAPAIVTLLGSLAAQEAIKGLTSMFTPADVIVVDRSDIFPKNGVGISIGDAKAHIQLPNKCGYLLVGAGALGCEYLKMLARMGVEHVTVLDDDVVDVSNLTRQNLFTLADVGSNKAEAAVKNLQRITNRSLPNYTPKGIAFTEKFRMASNSSVKNTIFLSAVDNIHARLLMDNYAVENSHIFVEAGIHGMQCSTFISVPYFTETYSSTVGSEASLDAGASCSVKGVPKTIEDAVFYAIELYSWLFKEQHDVFYKFYINPLGTIRSALQLGEKHFVNVIESIVGNSQLLSSTITPHEWASKAYAAHFKLDLPLKKMLIDAMANVKRRAMRSVRLCPRRQLDYPNTLMKSAVSIIESHFKAMKIPINDRKFIMCVDAVKRLFADVGVTKLLRQEGKLELQPLSFNENDGSDRMYLFAASNMRAYNFGIGQKDMSTIVKMAKRIVPAISTTVGIAASMAMLEVYKAIPLIDDVPVKDGQVPWGMLSKETIKESNISYAKSDGHLWFAVDHNSSGLLALSKIVASLRLVDYQRNKNIQHGLRNHFFNLSIMKYIANHANFPELSEVSSEMALLKGVVFSAWDYITIQKMAVAPTLTNAIRLPIEEKEHRKLTLGDLVFLVEKLFDAKSDAVYGFGTFVTLSEGNLHESVQDVFHIRDASVLRVIARDSKTQQPTDLPHIIYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCV5</accession>
    <name>A0A061DCV5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosome maturation protein SBDS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0209380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767971.1">
        <property type="nucleotide sequence ID" value="XM_012912517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCV5"/>
    <dbReference type="STRING" id="5866.A0A061DCV5"/>
    <dbReference type="GeneID" id="24564326"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209380"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="436" mass="47797" checksum="353BBCD072357A29" modified="2014-09-03" version="1">MCGLFQPIGQVRLTNVATVRLKVGGCRFEIACYKNKVLNWRSGVETDIQEVLQSPYIFTSISKGKLAKNDQLIKAFGTKEVDVICKQILDKGEIQVSKEERNQQLQATFKDVVTILSEVAINPKTGHPLTSTLIENTLKSSAFSVTLREPAKKQALKALAHLQQLYPNEIARSQMRLKITCTAGQRREVLGFLKANNAYIENDGASGGQRNSYPRSRSSSVASDQSEDTTHVASQSSAEDVHEKAKSNGEGRSGARNKEGSSSVETRAHGAVVNIRFLCCTKIYREIDSFVTHTLQPPGSLQLVALNVKDAGNVGLSSLQNFSTQTSSATIKRSDSTHVNAVKTTQEGVAEALKNLSIDSKEDKSTASTRDNAASKKPAFKCTNCKMHFDSTAEYRAHCKSELHVFNNKLTLKGLPPVSPQEFEELELCRKNTSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD35</accession>
    <name>A0A061DD35_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone protein dnaJ-2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768101.1">
        <property type="nucleotide sequence ID" value="XM_012912647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD35"/>
    <dbReference type="STRING" id="5866.A0A061DD35"/>
    <dbReference type="GeneID" id="24564456"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210660"/>
    <dbReference type="OMA" id="FICIKEA"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF58">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="96" mass="10943" checksum="0777E80FA43BE00F" modified="2014-09-03" version="1">MRAIKAWEIPLMHVYRLVCGGAVRRFSIYNHGLQREVKAGRLTHYDVLQLPRDASAQQAYLRLVKLHHPDASKRPDSPSIFICIKEAHETLADPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD46</accession>
    <name>A0A061DD46_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768131.1">
        <property type="nucleotide sequence ID" value="XM_012912677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD46"/>
    <dbReference type="GeneID" id="24564486"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210930"/>
    <dbReference type="OrthoDB" id="365841at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595711" description="Secreted protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11632" checksum="A0266D8172881DEB" modified="2014-09-03" version="1">MKGVLALAGAVSIALMRVAGAAYTTEMALCTDMCPTSTLVADDGAGISRCFDACKRLIHRVKYGDVLDNLKIDDHVSAPKDSPLKRIRKVLAKKKTGGSTSSAGSSGSESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD94</accession>
    <name>A0A061DD94_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769390.1">
        <property type="nucleotide sequence ID" value="XM_012913936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD94"/>
    <dbReference type="GeneID" id="24565745"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311070"/>
    <dbReference type="OrthoDB" id="10552559at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="590" mass="66548" checksum="2FFEFA68EDE09253" modified="2014-09-03" version="1">MLTRFLRAGEVVELSRHAMKLFTCAALFGLYRLIGAAAQGPTLSSYDLRRSDENNQLDGEGRYIPREDGETYAEPIVGDGVHHGHYVDARSYNEPSDNNLKGRAQRFTRLITGKIRRTTRKINTHNDGHVVHTTHTSRMVHARHDGTTEPMTTEWERHIRALMGKDGYSVGSSRDSDDESAQTDMSNLSDFDDSNEGCMRTRRTYGGGNESRMVYRGRYGGYDNLRADTSDMGEDVSGGMQDQDSNEPSDATEDVDPTVIAANLKLNSSGNTGYNGDSFLAERPMTDMYDNMDAENSPSNEWSDDSAEDGSSELSSSLDGSLERRRTTRKAITTAFGLKRRVEESLSFHRIRYIYVSEHTPLWTRVLPLGGYVIQDDEAADAMTRLRNCYEAKRPLLTDNVRRLNSLDARLKRVFASLRFRLGMDNINIPLQAGYHRITNEFRAVHVRATAYFKGLTAVVSYLQGQYRSPPRMPEGNQEMARPITVNMVEPELDRCVHDDSYGTSTSIRACLDMWELYVTADTFEIEAMIDHLWLNKLETPMDQIHAIALKALAKIEGALQVPQCLNRLEEFEGERELEDAVKKTGIAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDD2</accession>
    <name>A0A061DDD2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THUMP DOMAIN CONTAINING PROTEIN 1-RELATED, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768366.1">
        <property type="nucleotide sequence ID" value="XM_012912912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDD2"/>
    <dbReference type="STRING" id="5866.A0A061DDD2"/>
    <dbReference type="GeneID" id="24564721"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300850"/>
    <dbReference type="OMA" id="ICSELIW"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="264" mass="29934" checksum="658D30BDBF687D1D" modified="2014-09-03" version="1">MSEKRRNTTGNGRPPAWKRRNHDTGKLTIGSRGLLITNAVSRKHKEAMQECLTILREHCESVDPSFGDVNDKQDASSDAVNVEDAIKAELEQNKRFFDRFVPGPCLSQNLNVVHFRNENDVPSTYVRDIFHSMLHERTYKPRFLCRIVPYDVVCKAEGEPFTKTLTALVAREFPLSQANGISEKDDGSEPSTWSLSYACRNSNAIKRQDVLELAVQLVGRNYRVDLREPDKLIVVEVVKGYCGLAVISNYKPIAHFKLNISRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDD5</accession>
    <name>A0A061DDD5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0300950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768376.1">
        <property type="nucleotide sequence ID" value="XM_012912922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDD5"/>
    <dbReference type="STRING" id="5866.A0A061DDD5"/>
    <dbReference type="GeneID" id="24564731"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300950"/>
    <dbReference type="OMA" id="SFKMAAQ"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="179" mass="19700" checksum="B7F39C018A3F969D" modified="2014-09-03" version="1">MVYLARGKHVESQTSQAVNTISLRTKNGAITLIDTPGSFRLLPDSMKHIERAMSLIFVVDSADKHSFKMAAQQLVDILLNAKVAANGPSMLFVANKTDVMGSRDPDTVLHFVQLEAERILKAYKSEAHMKSIPPESLHILNRLAQENFSIYNTSLQVTLCKASVKAGSATDVLSFVEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDD9</accession>
    <name>A0A061DDD9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768386.1">
        <property type="nucleotide sequence ID" value="XM_012912932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDD9"/>
    <dbReference type="GeneID" id="24564741"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301050"/>
    <dbReference type="OMA" id="LAHECEE"/>
    <dbReference type="OrthoDB" id="366145at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1179" mass="133596" checksum="B1DFAA97E462D4A6" modified="2014-09-03" version="1">MHDILPLPVNTKKINGTNWNRHNIRLPGLDKEIGEGGSFYCRYVKADDTNPNDFRNANVHMHDDSFLHLYILPPMDVELFKRNVKTQLKSFVSKLKGKCLIIYGICKKENRDQQKSNCKTIDKIRHMLQSLSLRHNRLCLVPMLELSLLNAQRTPRAEEDMECNGETFGTKNWENVQLMMSECISETVAGRLSDIAAVIHKTSAHHTSESILFYESMLRIYGKCGLILDAADGYAELLRAVEADLMKKITPKDFVRAPFVFYMESGYGIDNESNQFDIYQYLCCTAIRLLEPVNGVESLSRICRIFLDCCMLTFMATRRDLRKKHLLWLLVLINKSLCYLRDCMKSTSDQLGIAETVISANTQQKFSKPSTLEKLRSAIKRKKSRHLQNEEAVEHSGHLTANLIATDTNEAPKKYCQPLHSPNGVECVYNINNSKCIRRCIGLLYTFLYKTLKNMDTAVSSDDTLEVSNIQNVELPYNLYRTMELEMWEAVKLPDGRQRMMAEAMENASLNFSHGDMPRFSNVMANLYGKESAALSMEKDSSQLGWFLRALNKGDSKHVFAWFGPHEPNVHLNDPLDSVKTVLQANLDCLHNYPNICLTPTQIEDEAVNDYLRVLSDAKLAIDSTRGYMQTYGQSLKHKTDICKIRLNVYTTVDCLKVNIHVRLCEDQERMINDHPPTLAHECEELSLSDVTLHRGLNVYVLKHRFSKTCNYTLESFIISGETFEVVQRPCTPIPLGVLSGVIRALKTYNIMPSYKLSALVLPPSFIRCDKEDTITLTARPCSDAITCSDPVLLTGVKNYIAFYLSGFTVGRIFFHKSRLIYDTEHFSLYSDEIKTSCDYTKTDDGIVLNLTKGRASSHVICASITVDSTVNEDKICQTVSIYNGRRLDFNLEFTIIPPFCREIITSDNALLQVVLGPTAPFYTEIGSVVVNGCLMVKESTLLERGSDFCISIDGNDGETGTSYLLTPPNSNATLSTGKFRTVGDLQMRSAPHHTTTAITAERDFSSDKQRETPEDIAANNGCTALITGEHKVIVSYRILRHKCMHHRTNVGGELESLSNVLEYRFNLPQLTGSDVTVEYNTPPFCFIGMLFEACVTIRSAKEVSFEYELESDDNWFVEGPVRGKNQVLRPIDCLQLHFKMMAIERAGGGIIRLPSIRFWRLRAPLIHKEIFLLNNTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF9</accession>
    <name>A0A061DDF9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0301440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768426.1">
        <property type="nucleotide sequence ID" value="XM_012912972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDF9"/>
    <dbReference type="STRING" id="5866.A0A061DDF9"/>
    <dbReference type="GeneID" id="24564781"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301440"/>
    <dbReference type="OMA" id="NFMRMYI"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="168" mass="19419" checksum="06131A81627FA9ED" modified="2014-09-03" version="1">MLKCLNLISPTCPFNYRKTHLIKVPKELIYATVLDIPSYSRFLPWCEKSHWIDDVVTAGPSISQGQRRARLTVNFKLLKESYVSEVTFEPCSLVRAVAADSSLFETLDTVWEFEEQSNATLIKFYIIFKFHFGGYQSISASLGRMLTDTMLERFVKECHRRHSSLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDG8</accession>
    <name>A0A061DDG8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0312920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769575.1">
        <property type="nucleotide sequence ID" value="XM_012914121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDG8"/>
    <dbReference type="GeneID" id="24565930"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312920"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595727" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="828"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="957" mass="108291" checksum="1EC588E63E12EE05" modified="2014-09-03" version="1">MAKLMRVPLAFCAISLQLLEFICAVEYDFMNGMSSLDTNPLVAFHINMDNIGIATLACPRQVNGTEYVWHPQPTADHNFSLKTYVIEDGKFRSVPFSKVVITEAPRPYGWKATKELQTDLHIDLMDDDIYAITEERLVFICGPRDVVLSDALQGQLARLREIDEREVYLSDPTTSLVDEISKIGKGLGVVFLRRGLNHQLLQGCGSRPSKLFAPDNDVTVDPVTGTRSCVVNPMSTLRTGFVCEGRIEPNDCMKSILNKDRVMAAPRPYLYRSFNAHKPWVAARYFNDVALPRFNGECRCIDTKTGRVKARIEVRWKTEYVCDIASMIARNRFKPIRGTWCSALLHPGATLTIKLPKQTVKSTAIGDEYIEDVDDIDEDALRVPYSQLPSTHAYESEFKPDTKLTLRQLQTIHDINDYDEILIYEAFTGGAIEVDVSQMERGEVKLKYRMDRPLALRSGLNSFLYHWTFLSRNENVLEKLRAVVNVSFAPTYRYNIIGSDRWKLGVFDPAKDVSSLAIKDMGNGIGETYEWLLNVVRGEEQAGIQCGPNEELFPNNCESTGYDLSSNKIAPFPTSVRNATLYPVRGFQVFDMSFQNIPVSHACSCVDVRGYETSRLILRSNRHEEYTYTVRREYTYQRLLPYSLLPLTEVALLYGISNPMRSIMLHNMPQRPIKLHSGTEFFMRCVVDHALYNGGNNAGATPTWFPYCPGYYHYTVYTIAEGDMLIPKRNEDRIAGTKYGLEIIMPEYTDEYTDLMIKSNSGAILVSRDPGHSEYVPMTFVCGKELSESDFGPINDGAYADTIPQVIAPLEEYTWNVVQIDVEMTDPYMQGCGVTYELDELFKPETPKLYNAEGQEIGCKIDIQIAKEAAFYCPAPYVLDPPNCFDQVLVEGEAKSLSDISQSLVASHSNHFIILKFDSDNIGPGEELRQTPPLECRCTTVKRIVLSTIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH4</accession>
    <name>A0A061DDH4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768456.1">
        <property type="nucleotide sequence ID" value="XM_012913002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH4"/>
    <dbReference type="GeneID" id="24564811"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301740"/>
    <dbReference type="OrthoDB" id="10586330at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="65" mass="7370" checksum="E84B762918C910C9" modified="2014-09-03" version="1">MEPDVSDTVLHFDFENDDVCAITGHHLIFICGPRDLVLRDALQRHLNSLDGTIQAQGFPWTPPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDM5</accession>
    <name>A0A061DDM5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768571.1">
        <property type="nucleotide sequence ID" value="XM_012913117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564926"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302890"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1842"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1904" mass="212187" checksum="543AE87332CF379B" modified="2014-09-03" version="1">MAPQFKRLTDCPENLREAIDWLIQVRHGSDGRGLGELAKALKKLIEDAIRDAYTSIISHLFTLIESFKYYECCRPRLESIDKLQNLLKEPTFLADVSLNDHLEKIKYAKELCEKHHYIESSKDTALKDVNVKLAKLKELSGNLNTFNKNSEGLLTNLCNGLSTFLGFNPSSKGYTGQGIVYSDLDRLCDGVMGFLSGVLEAVQDDDAVKTYDDNGHLNKLPQEISKKMYKGPHEFSLTLSHTGAVLGYYDAEVNRRINAVVENNSNGTLYALQSQIDKNIRNLQDSLTTKKYEDVVAQWKDVVTDGLTALIKSAESAINALDTPLKTKVANDFEKIETAVEALSESNIMDVMQLRELSGAVRDELRDLDRYVAAEIHLQVERLEKNLKQEFKSKIHAPISHVESALKTVQSHLNKWFDQANIVVSAASSKTKAILAEVTLRADGAKPTKWNNVESAAIKLQTRADELRGVAKAAKEELKSQVENALKQVLFLDRAVRKGVKTVKDNIKGALRKYIKEQLLEDINAKIKEIINGEEGDEGLKQIVDGVKKYADLFKQKGTQGFEGVVQKWIADILRKEPVKGLLNEYFQMKDRFKPPYDQWNSIRENTDITEGLARIIADQLKEEYVEKAVDAAKSYTASTNAIRSYVTVVQLVCSTFSKLVGLKIKASGLVTLADKIVRGIETGQELSITKTGHLTNDTNITRAVQHTLHQLVGVARHTGDQTDELVLRCHIGNVEVAIDVANLLEGNVGKAAKQSITSVHAISPSSALSDSIYNFEGRILGILQKDFGKDSDGDGKVETLVVKNFEDYDGLIKQSKVAGLTGDAKLSGHANEGSFPEMIKGIEHKLNGTEYLGKIESGTHRTIDPGATDSNFYDDTFQLLVGKVNRELQTLCNELRRLAEEGGTRGQTNNKGVQTLLNDLNTMLGQSGLNNGDMYGLAADLKSINADIVKILGTDSTKNENGNLTDILAEAVKFVDNTLKDGAKNCITNIKAELTKRVGLARDSIKSYALDRHVFRKRTELGKLKHLIEKQREAIISKCRIDGNTGVKGLLKAVKSQLNSALPITDRTKLDGFPGKVRDFLISLWEHVGGQFTEDNESFNAFGLVKKKFVTLLDEINNSGHFTHSLAYNLGKLKSVLDSMSPLKFSGHQHPMLLDAIKDGLTRFHEELRKAYIRVYDGSKPITWDEPFSKNTTEESRNAAKVFLTMMNILFNNLNEVKEMCNTASASRINTRTELGEFLTTCGYNVSEKGRQNGELQDKGSMQGSHIYKLLVGDGQNVYHVDKAATRALEMIYEDCLVNYYRTCHLPTPATKHPSTICDILQWLAGLPYNAVYNALSHDAFSDLFEKPEKDDATKSDTFIVSINEDPDSLPAYPETISATDLSQTLTLVCHHAEKTLIAILGHGNSDGRYACDFNANAGKFLYPSKGSQCLDLLVELLLRLYDQLYFLHVECYRTSDSVSWRDCYYGRHVAGSDWRCNDKQCVNQMGNQIADQKVNQMCGQTCDQHPKCGLKSPLQSFFEDGLPGFLPHPYKKADCKLSCAAPNHRGLLCKTPMGFADLSVKASHTKTGEYLSNVLSEFCGDAEKPLTKMCRFLICVLSRPPQTLGDMFSFYYNLLNGWHGKGKGMDADKTHKRHAFEAAVTNAYFGVNYPTFDVASVINNSKEPSEKHKDGNLLCLVGCKNSSVPSAQCGRYLQPFGINTWLAFSSENADKYLSWIVYITETFYDLLKKLYDECCNNCNKPGSRCYDKSCVKNCVASHSYIHSAGCTSIAQCPFTRPTLSKYGFVLRSISNLHGATDTKTKRTCKDLCNALKNVLNEKNVLFTLAYRTIPKFLYDIRQPFIWLTVALWLLSLLYLIHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVSKLAELTYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE27</accession>
    <name>A0A061DE27_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3' exoribonuclease family, domain 1 containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0403970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770095.1">
        <property type="nucleotide sequence ID" value="XM_012914641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE27"/>
    <dbReference type="STRING" id="5866.A0A061DE27"/>
    <dbReference type="GeneID" id="24566450"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403970"/>
    <dbReference type="OMA" id="VCSIQKA"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="5">
        <location>
            <begin position="47"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="212"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="283" mass="31156" checksum="54F09F35D9ACC3CA" modified="2014-09-03" version="1">MVAKDRKALSIQHIDFLQLPEADTSTVKIGETLLHAKCRIDGRGVNQCRSLRVKTYSKPGHVYLSLGNTDVFVAVNGEISEPNLERPNEGTLAFYVEVAPMCSQVYEPGRQTEHELQILQILEKAFKDSGAVDVESLCIVVGRYVSNKTPVWSLRIDVSVQQNDGNLQDACVLAVLAALMTFRKPDTCPSAGDADAIQLNAYYTSPLSMYHTPIHVSVGLLEDAEHCIVDTNSFEELFVNTHVSLLFNNFGDLFAVQKHGGGAVTLERIEQAIEVRFGDCIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE34</accession>
    <name>A0A061DE34_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770125.1">
        <property type="nucleotide sequence ID" value="XM_012914671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE34"/>
    <dbReference type="GeneID" id="24566480"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404270"/>
    <dbReference type="OrthoDB" id="10499672at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="99" mass="10876" checksum="E1BE51E0889AC06A" modified="2014-09-03" version="1">MLRFNECKAEDRVLPKPTEAPEYNADYTTTMMSGGLLASLILKVPSAFFLTGAVFISRCFAADAPIEWSKAIVPLSGMMPSLFRLTTDVVQCLWNGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE86</accession>
    <name>A0A061DE86_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770250.1">
        <property type="nucleotide sequence ID" value="XM_012914796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE86"/>
    <dbReference type="STRING" id="5866.A0A061DE86"/>
    <dbReference type="GeneID" id="24566605"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405480"/>
    <dbReference type="OMA" id="PLYRCAS"/>
    <dbReference type="OrthoDB" id="432202at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="485"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113094" checksum="AE3EE11DCC2C753C" modified="2014-09-03" version="1">MHGSNENIWSNLSVKDIVEDRNVYPSLDTSYENNRDLHGYICDNHMSLHLVAIVAAYLLLIGATFQGCGCRRCSVFDRGSKRFGLQRKRAHHAAFLSRHNPWNVDVYGISVQKALHAVQEDGSNSTSSELLITGVWNTLAKIDSAASSLEVKSVSRFEYNREAILDTYEAARDADSALTGNSFEGINQQLFTRFDGDDGVERSVVAKQVISPGVEIVKVPQSFVLSLADIRTDLLSNHRLLQQQPPTDNLSHAFLAHIENLKRLNLGQFMREPSIACSSGDETTHDENAIGTHHDEKRHSCGSFDTPAQAGCNSGVETTCNVGVGVHQNGNIASGHYGGEFEGRLSALIASKKLCMLKTLLVADSVLSTGDAITVALENKAYELVYLNRNERELLLLSLGLAGIYQRAIFSFVMRMIHDPVAIPTLPDAEVVRLSWVHHLLTKDMGHLPLLMPVSASNQIQEPIVSHRLRQRLIAVNDVMTAALDPLSVVQDRIDKLSQAHYKVEDTTPLQSGCGPLIVDRKIKAEVAMEEIESELLAFADGKGSTYSTGPFEWNIDDVRSVLTVDERSSFESTEGSDCVDILLAFESYLTGKLQPQLYKHVSPGAWIRAINDVITRRTFTNLFASIVAHNIRTIGDVGHDACDNYTQRSFLHNRAPGIMAKLATDSSSNSSSVGVETGEAYIVPFLDLVNHDSADPNCAIEMDSGGGGGFVLKSLRSIQPGEELKVNYGNLDNNVFLLDYGMLLPLQQDQGVLMEVEPQLITRAAESTGMSELLPRTFPAGLPLEKRDLLLRVNLFEIPSDKGFLSLYNEPYFDGMPVEMYNEFASKFLARQNSQHPSFDDDIDMESIRQEKSQYHPVTGEIFNHGEVTGRKEPMKLVKISAGGVPDERLVCALKICFCRTKKRLQWLEQQDTKYLATSVNSPLDVDIFKAASLVCCEYIKSRYRETIIDDLRKVSHKDLFAANGVTGGSAAPLQKLRECNTVDIPNAVLICHALRAKMPLYRCASYLESIGRDFKSNVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA0</accession>
    <name>A0A061DEA0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769146.1">
        <property type="nucleotide sequence ID" value="XM_012913692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA0"/>
    <dbReference type="STRING" id="5866.A0A061DEA0"/>
    <dbReference type="GeneID" id="24565501"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308630"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="90024" checksum="51B3BFDCFBF72F72" modified="2014-09-03" version="1">MEREFEQKTQDAIYNQTVKELKLAERQKKDAEREERDVKHIDDELKYIDHIEKQKYDNQVAEVSALDGNTVVLPKTYGIHDLDPSLLFSGTAAPRLSHDPAVYRRIYASAADHVANIVKQKVDEQDMIQNTKTRLGMFNGGDVDITYPLPYMARNPDYLELQIDTPKRAVQDTLHDMDLDDLYSNADNILRDEYITSDMTYGKDKGFSSVPQTNFDLDFAPGRIGVEGYGDPGMPRDPSREVSERLVPAFATPDSCQNPWYVTPSSTSPTPPTPAPLPVTDHLPPPKTVREMLYWFVGLNTQGYVGLITDYIYSILKDANKNVSKISDVIEVTGDPTNLDASHVADKLTEACLYGASVLYRLKYRDDYKAYNNLKFESEYSKFRYASDPAGLLCQLRDYVYACHHQLAFLKAQCKRDKLSGGWKHYHYGSDIKTSSPLQAFLTDGWDSTFKTHLFDPCNLCLKSRVRMGFRDKDLPKTSQQGSVISTILTPSCGGSDPLLTLASYLNCLTRRTPRTTGELVSYFHHFGNELHEYALKALSSLGTAITKSHADCPDWDCLGASDLQAVSGLRGSEALNMISNNNHDNEHPKTLSTLVGCGSDPDNCPPHCSPITYRAYALYSQSFAHTYLSWTVYLPDLLWESLKRLHYDLKKHVSTKCSSLYLCSTALPLLYTHGITPPEGKSQSTVKCYDVMSKLKEIVDGKPIASLMTAMDNFLYGIREPFIFTLVALWSLAFLVFANTMLYRLDVLRIRSHLIRTKASHHIDVKALLTKGRKMLSLYKDVDYFDEDPIGYLGVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEC1</accession>
    <name>A0A061DEC1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BETA-CATENIN-LIKE PROTEIN 1 (NUCLEAR ASSOCIATED PROTEIN), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0309230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769206.1">
        <property type="nucleotide sequence ID" value="XM_012913752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEC1"/>
    <dbReference type="STRING" id="5866.A0A061DEC1"/>
    <dbReference type="GeneID" id="24565561"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309230"/>
    <dbReference type="OMA" id="TDWREQE"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="507" mass="57570" checksum="A780DA9686DEDCBE" modified="2014-09-03" version="1">MDSTADEEREAITASNLKRHVSVLEKRLLRNQQVRLEHPEDPERWVKSEVDLDEQIRLFHDICAQPELFGQFEELGGLRILRDALSHPNIDIAMATLAVLNEIVDPEVLVRLARAEKFVRSLQELSLHVPCVAALLKIEEDNSEVDYEGVKNALELLENLMELFPSIAGGMSENRELLLFLLRRMKASKTLEYDSNRVHAGEILCILLQHSEECLTLVGGQELEGVDKLLRIITVFRKKDPEGVEEEELVENAVQCLCRLMLIPSNRLLFGKLQGVKLLIRLIKERRSTYRLAITLLDYALMDSPENCALFVSGLGLKCIFSVLMRKGVRTKPGSEDEKLEDEHVLGVVHSLCAHSSGTELARVMNKFVEHKYEKLERLIELHEKYNAMSRAAAKSIQGRSGSVRSMYSALQLNEDKQKYLERYEAGLSICQLVDCIILRLYNMGNSNLSSCLLVLLHNKGVDIQDIYNNISDYLEHLDESANDTREKVDRLLKTFLTGASDSGLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEC2</accession>
    <name>A0A061DEC2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769211.1">
        <property type="nucleotide sequence ID" value="XM_012913757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565566"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309280"/>
    <dbReference type="OMA" id="WGLIRRI"/>
    <dbReference type="OrthoDB" id="364253at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1830" mass="204911" checksum="1486BCCD0681ECDF" modified="2014-09-03" version="1">MTRDEPESPSYFRNKVAFSYGTIRRSPAEIKVQAKIQHDRETPIFFEVISFDNGPLPFNSIAFLPPGETAVLKMQNVSIHRFRSQTETALSESDVNVFARVVLEDGGRRYMPLRLMDIPERNWLTFVYEVDEDADDTTSRVDGLLVAGRLERVSYVLLRHRDAAGTWTVAPEEECMYFGGNTLDALKCKAAIDATAAVPHIGPQRPEFEVTSMPLSHHTRYTDVATCKTLFELREAAMDPDREDHLVEYIIGRLEDFLKDDMDSSEFVNLKELFSECYKHTKFIFSDKIPLNEVIVPVVEKCIKNVTFDSEDLYFGILQMLVRDCDVAHTLMFDKGFGKNLVERLVAPENHRWVERGFMLDLLVEMVSHGKCMRNFLQGDPGGKVDSLCDTLLLGAAKLRRFSLFNMTTRMEALGQRVELFLALSRVEQLFQSLEPKLKEDEGPTYEHLTTLLQSFNEAVEMIQTHHNGKVKHSVLRDIHEVRQYTVSYLLETTMHKVLTQLMGSLLTHLKRFPVAPMYIDSMLELPLWFVAQYTNLIDFGVCLLYMTDICDFVNGMTLNNALQNGMYADSRATCCKARCQSMAIHTIVLKMASALLGKRSCPQMVSALHRICTEYPCGYRVIPTILAEQSMIQTVLQMATSAITDMTSSGVGAGGHRDNMELWQLFEIVSNAVLKDESGILLYFMGKQLISPLGSFVDMFVPEGTPAADLELQPLCDLRNNLLRLFKSAALMRPAKCGRLFDDVEVYLRDLLASAKVTLHPDTLKQSMSKLSHMDAMSLVNQPLRNSVFLMDPSQAKSIPKSMVSEQFGTVYSVSADTVELGAVHWTPNERYSARVTDLGVTADKAGHFKSCRLYVAPPERLPEFVHYGVRLLSFASTMDQYVSVFSDLLRERENTETLLRLWVHAVASISPDIDTVLNVEMGAFKSLVGYEWFFSSEDAIPLVTNIAQIVYSSLHHLSCDGHCHEDTDEHRKVTGAPVRYINDDILTLVVLSVNGVMMNRRWAFEGRLGRTSRKCLRWLCKLMSYWYLRYEKSQGYLMNKLMGWYTTLPCMADGAALLITSCGPVINPKCNVVAYVSLPEDEENEALLGRRRARVLFEGREYTVALSEKEVKLGRDVPNSAVWGLIRRIESLKVSVLAEFMCAVATRCYSANPCTVVLASEIAHFLIANGAPMMVFLSAVSDRCLEECLKAGSDASRSGNASGKAYRLLTFWSLVAKALVSNDSAGPTAVFKVNNWILDLFSRYTKGCRVITEGCCRVLFDGYVHLFRCHNKLWEGHHATLTRDPEFHNYMKNINGSVWWICHILNGCKARDTETGSSDEGSQNKFATVDFDSDIHLDSSISLSWEVILAGFAALKHAFKIPFTALNILYTVLSGPMELMVQIINKQIDSEIIKVTPSTTLWLNNIIRQLCDALLLHGSSEEADGSGNSDAPLQLLILQLLHDICASIHQTGPAQDVFICSLVYGTTHSADHDMLMAEDSLGDGQTEGAQPQEDIYSDIVGSSKNRLPRRVLSSAASQNAANGPAFKNVTDALEAFRDAVAAELALGKAQKLQGIALSSQIANVLLMLNAFKSLSSVIAKDAMERTPPKSLPGYIFLKVPSYTGLFRHSLGDAWSTDGRGPSSTRSILTRVIRMTKCENWAANTCFVNQSVPSPLLTDDRRQMRWLSRCFMFNGSPESVEMWKAVRYFATAKLLFADELMQYAPVKTKRMERPLPSDGMRYIRSVSTRAPSKHVDAYESEKAGVATDDDGAITQENIEKAVARLNGVITSQTWLDFDNDLVTNGLNLRSILINPGLLKDYSARATFLNALSRHVLIKELLISVGVDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE6</accession>
    <name>A0A061DEE6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769331.1">
        <property type="nucleotide sequence ID" value="XM_012913877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEE6"/>
    <dbReference type="GeneID" id="24565686"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310480"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="74" mass="8135" checksum="A5366768A7DDBC83" modified="2014-09-03" version="1">MGILYLQLVKSFKELRNMDDNAKAAVGSVIGGLALGISVFLLVLYIMGKIYNVSLGEIFGQIRDGFRDSKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEF3</accession>
    <name>A0A061DEF3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ADP-ribosylation factor family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0310830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769366.1">
        <property type="nucleotide sequence ID" value="XM_012913912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEF3"/>
    <dbReference type="STRING" id="5866.A0A061DEF3"/>
    <dbReference type="GeneID" id="24565721"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310830"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003539">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR97180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="458" mass="50710" checksum="41F5716269590E9F" modified="2014-09-03" version="1">MGGAISRLYNRLMSKQDVRILMVGLDASGKTTILYKLKLGEVVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWKHYYTNTQAVIFVVDSNDRARIKDAREELHKMMNEDELREAFLLIYANKQDLPNAIPATELSNELGLNQFGNRTWYIQAACATQGTGLYEGMDWLTNALKHNFQQSAMFLTLVICVLLCSEVFAPCKGALLPLRRFDAAALASRRHGLPASSSLRHVGKGLADYVPSEADAASNLATWRSETWPTLDRLFANSIAGLRKASLLSELVLSVKCSLEALDAALAPFRGVPVIYLLLYVDVHNFASRFMRLLRSQCRKCDSYARFTALDSSPRLMSMLQGHSQSMISMRDAASRFMGSLKVNVPGSRKHLLPRISTMPSRYWGAVHRSARRSGLLVFMAGCCLCAVNRVLLPLLLGQVLPALSRGIGLGSLSGLSDVLSLQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES4</accession>
    <name>A0A061DES4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0402730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769971.1">
        <property type="nucleotide sequence ID" value="XM_012914517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES4"/>
    <dbReference type="STRING" id="5866.A0A061DES4"/>
    <dbReference type="GeneID" id="24566326"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402730"/>
    <dbReference type="OMA" id="EMHRTIC"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="474"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="960" mass="102993" checksum="224F5922E608F371" modified="2014-09-03" version="1">MAKIVLNSVRMLSMEELFSVALSKRPLVLEPELAKTLGVAVSTSIGRSEASDKAAGAAARGSSYRDSLIGRMICCALLQKAVRRKPPPSSGFILKLFDALNRTSFDVSMALESLNLRAEGPSEVASTPSSGVVRTLASVAQIGAAGSDKDALGTIASSLGLTADECAALSRGQTELFATVSVLGLVLSSLSKFSDCAVGLACESLRIPTQCLSSAEIQKLPHCVGVARNLIWLTEDSKLIPSSSNSGDASLELILPSYMLANGELEHLSKAVIKITSEMFAAICGGMNNPASQKVAEHAWLFALQSHVANLCRCLTSVATCYMSLLRGLSNRFKVISSEIGHSDDASGVGNASGAADVNTSSSEYENLIQSFESSLASLDSTSVNLEKLDKLAGVCGDMSVACVSLSTSILSTQQRPKGKSAEAAKAGSDAGDRKLLLGHGNLGVAAYLRELLGGEGVSGVRSYQVLCNSLAGPRLLHQSARVETLLIPRNQKVRKLKVPKGTVDTLPEEMLVRTIVLDAVRSIFKQHGACEIDTPVFELRETLMGKYGEDQKLIFDLKDSGGEQLSLRYDLTVPFARFLASNKIDKMKRYQIGKVYRRDEPQINRGRFREFVQCDLDYAGVHPPMVADAEVLFILIRVLRMLRPGGFHVKIGHRVVLDAIMSHCGVPSEMHRTICSSIDKLDKEPWANVRDEMMCEKGLSVSVVNALQEFVETKGPMLDVVTFLRGKNIAGATEALDEMVLLNQYLSAYGVTAEELSFDLSLARGLDYYTGVIFEAVLTGASVGSVGAGGRYDGLIGMLSGRNVPSVGMSVGIERLMKVVAHGDVSSDITDVFVCTVGDESMALERLRLCSLLWDGGVTAEFHYNARANLRKQFDAATAKRAQLAVVVGMSEVAAGTVRIKPLNYSREDGTDAQDAGKSEEVVVSRADMVHTVRRILGEVGGRYVQLTKNVIPNMAQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEW6</accession>
    <name>A0A061DEW6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770181.1">
        <property type="nucleotide sequence ID" value="XM_012914727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEW6"/>
    <dbReference type="STRING" id="5866.A0A061DEW6"/>
    <dbReference type="GeneID" id="24566536"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404805"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404805"/>
    <dbReference type="OMA" id="INEQIVM"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="234" mass="26325" checksum="2719D5500B20CDE3" modified="2014-09-03" version="1">MKFDGGVVGSASLLLTRVSDSYGRQHRVSCAQRIQQLSGDTIFCTSGDVADQQYLTKVLQAAVRHEMLDHNNDAASCKLDASALHTYLHRLFYYRRSKMDPLCNSAIIAGYSAGAPFLGYCDMYGTQYTDDFVATGMGKYFAIGPLREQHRANMTRDEARLLAIECMKLLFLRDCSAGDRIQIAYVTARGVEFEEPMKLEGEWYVRMASVCTFYRRFEKFVAPTSKMAIAGCQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEX0</accession>
    <name>A0A061DEX0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High mobility group protein-like protein NHP1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0405000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770201.1">
        <property type="nucleotide sequence ID" value="XM_012914747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEX0"/>
    <dbReference type="STRING" id="5866.A0A061DEX0"/>
    <dbReference type="GeneID" id="24566556"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405000"/>
    <dbReference type="OMA" id="MKNMGGK"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000037">
        <property type="entry name" value="High mobility group protein B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR98015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="95" mass="10632" checksum="A0E015ABE894CB05" modified="2014-09-03" version="1">MAPNSKSTIKKGKRTKKDPNAPKRALSSYMFFAKEKRGEIIAKNPEMAKDVAAVGKLIGSAWNALGEADKAPYEKLAEEDRARYEREKAEYAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZC8</accession>
    <name>A0A061CZC8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0101020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765959.1">
        <property type="nucleotide sequence ID" value="XM_012910505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZC8"/>
    <dbReference type="STRING" id="5866.A0A061CZC8"/>
    <dbReference type="GeneID" id="24562314"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101020"/>
    <dbReference type="OMA" id="QSTMPID"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000111">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="334" mass="38626" checksum="4E8E07AB893B0BB9" modified="2014-09-03" version="1">MSDIDRDIEQLRRCEYLSESEVKLLCNKAKEILIEESNIQRVDAPVTVLNFSLHSLVYSGEKPRKATAWTRESRRISICGDIHGQFYDFKELLAVGQNIPETNYLFLGDFVDRGYYSVETFLLLLCLKVRYPDRITLIRGNHESRNITQVYGFYDECMRKYGSVNVWSYCTEIFDYFAIGALVDERYFCIHGGLSPSFSTLDEIRYLDRKQEVPHEGPMCDLMWSDPEAMDGWGASPRGAGFLFGGDVVRQFCHQNKVDTIARAHQLVMEGYKWWFNKMLVTVWSAPNYCYRCGNIASIMEVDENLNCSFKKFDAVAPNKRGVPAKKPIPEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D051</accession>
    <name>A0A061D051_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766234.1">
        <property type="nucleotide sequence ID" value="XM_012910780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D051"/>
    <dbReference type="GeneID" id="24562589"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103620"/>
    <dbReference type="OMA" id="EYNKICN"/>
    <dbReference type="OrthoDB" id="346528at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="143" mass="16105" checksum="D8F238A510A41280" modified="2014-09-03" version="1">MKGIGSFSKRGAAFLPIKWQQMTQQRYLGQAPSGRQLNSIDASWTEAKKLFYKPALGYAEFAKRVEALRMLAFWALVTGLTVDIVLDPPKSQYWAKWNLIKMPSRIMEKFGGQTKTEAPPAPAKLGADLLTDAAREYHRICNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D056</accession>
    <name>A0A061D056_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0103670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766239.1">
        <property type="nucleotide sequence ID" value="XM_012910785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D056"/>
    <dbReference type="STRING" id="5866.A0A061D056"/>
    <dbReference type="GeneID" id="24562594"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103670"/>
    <dbReference type="OMA" id="CKFDYRI"/>
    <dbReference type="OrthoDB" id="1302410at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000388">
        <property type="entry name" value="Putative RING zinc finger domain superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="302" mass="34072" checksum="1637A9DBCE2F050A" modified="2014-09-03" version="1">MSYANLSSRIDINANPPSTREALTLRFIKANMARFPSHDNATQHPRSESIPFGGAPLTRNRSAPVTGVLSRTTSIQPPVSTPSASITRQRPAMYPSSRRQISEPVNMQGMSPESTLASMQRDIEALNRVLHDFQQNFTISPAVTHEARDGRPLVRRQSERVTEVHALYDGVDNGLSPMTYDPHSVPVARSPRSVLDDEQINFMNPDQMLQDVQEYEDAVPTPVGLADEIISQFPVAMFDAPAAEKWDEDTRRCAICLEEYEQDQRIRRLPCTHGYHKVCVDEWLGRSTICPICKFDYRIMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0E6</accession>
    <name>A0A061D0E6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766334.1">
        <property type="nucleotide sequence ID" value="XM_012910880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0E6"/>
    <dbReference type="GeneID" id="24562689"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104570"/>
    <dbReference type="OrthoDB" id="364327at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="242" mass="27604" checksum="CBD8E283FC7F9238" modified="2014-09-03" version="1">MGLLHFPPKDAELPFQVDLESFNFSDHVDVFKGTFPDGGVYRLVRGEAGTIRVSYGSVELVPKVFESYGHKDVYVEYFVRGDERVIRLFAFIDRHGHPAGYRTKTFLVNSNGPVECDDHAVESFACGPISLDLNITPNTPMHPFVERKLLLDNGLFGFVYTLARKHRGFEIYPWRNYFKHPYKIGSVYYTLFTDEGVVPGTQPLEADSYLVRAFISDDHIEVHVLKPKSVKTFNIHPVRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D123</accession>
    <name>A0A061D123_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766504.1">
        <property type="nucleotide sequence ID" value="XM_012911050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D123"/>
    <dbReference type="GeneID" id="24562859"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106270"/>
    <dbReference type="OrthoDB" id="514276at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26272" checksum="2A6AC29F2437D60B" modified="2014-09-03" version="1">MENAVPLTINYDSTRAYPFLSSKFKRRDPNVHFYLPIECPLAKGCTDGTCPLAHTRLEIIFHPIVYKTRKCKMISMGFCSFPQKCAFYNNDSEKMAAQLLWLVWEKTWDLWRVNIEAILGMHNKFIGSVLRMLPTIKNYRGNVGDFLRKLTNGHPGSSILDTAFDQTLRSHFARVRKGGPKPARHSPSLSLLCSKYNPFHAGDWFLQHTDDIFYEWFFNREVELMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D148</accession>
    <name>A0A061D148_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766003.1">
        <property type="nucleotide sequence ID" value="XM_012910549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D148"/>
    <dbReference type="GeneID" id="24562358"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101460"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="25032" checksum="51D649CBF136CFE7" modified="2014-09-03" version="1">MLLKFLDQPELANQWFVGGLVKRCNDLINKSPGGLAKYFRVVDESDENVVKGKGITAGAIVENLDKVVHGTEIFLDDIKSPGEYESAYSPEAAWSKSCTQKPEDCAAVFVGIAPMLRASISSLNAAVFAAKLRLPPFIACKRMQQLTQALGYVEPQRRAGMSGFDVPKALRGLYLRTLITLCDFTGFWAFCGSNNPDLGAGKHGNYPVSEVDFDVNMKPIDASMKIGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D160</accession>
    <name>A0A061D160_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0101610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766018.1">
        <property type="nucleotide sequence ID" value="XM_012910564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D160"/>
    <dbReference type="STRING" id="5866.A0A061D160"/>
    <dbReference type="GeneID" id="24562373"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101610"/>
    <dbReference type="OMA" id="RMVKWPA"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="294" mass="33103" checksum="1AEDF6A300DA52A7" modified="2014-09-03" version="1">MVLQFKASNSKKGSEEGAASAMNSSAGKRTSATKDSKVAPLPKVLKQVKPTKPRDHLFSPAPKSFHIGGAIRPRVNLSRYVKWPKYVRIQRQRRVLLQRLKIPPAINQFSYTIDKSQAHQLLKLLNKYKPETRKEKAARLLADANAIAQGQEAVSKKPYMLKSGLSHVTNLVEYKKAKLVVIAHDVDPLELVLWLPTLCRKKEVPYCIIKGKSRLGKLVHKRTAAVVAIDNIRKEDQAEFEAMVKTFTAMFNDNVELRRRWGGHVMGVKSQHRQVKKEALLAMENAKKLGLAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1D7</accession>
    <name>A0A061D1D7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766113.1">
        <property type="nucleotide sequence ID" value="XM_012910659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1D7"/>
    <dbReference type="GeneID" id="24562468"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102550"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="182" mass="20842" checksum="DE36AC1FE374C598" modified="2014-09-03" version="1">MPSVPKEYITDPPKQNAPLMRAAMHLSNSFKSNFGGMVGLKRRGNMHFSNCSRLNQKNAIKKSRLSRIPGYTLYPIYGIQLPLKFELRNVMLWGNAIPDLFAAQKYPGRVYPVVERCIAARRQTEDLLVGMVAIQKTEPQPSPRRMLHPVECREEKIRATPFQEIYAVTIRICLTVVFETVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D201</accession>
    <name>A0A061D201_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766844.1">
        <property type="nucleotide sequence ID" value="XM_012911390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D201"/>
    <dbReference type="GeneID" id="24563199"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109560"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="83" mass="9036" checksum="828A25BA17E9ABAF" modified="2014-09-03" version="1">MDKSASLDSMSNTTQSNKVNAISICVEITSFCRRTEGVDMALSVERKRRGRTTGPPHSQGQGTIPALAQGERLTTTYYGKRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D243</accession>
    <name>A0A061D243_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766879.1">
        <property type="nucleotide sequence ID" value="XM_012911425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D243"/>
    <dbReference type="GeneID" id="24563234"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109910"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="146" mass="15961" checksum="6A7F146E2D3B9A9D" modified="2014-09-03" version="1">MASVLAALRVNERLRGLGGEDVERGAVSGSGECHRDGCEECDTGSCMCNCCQRKRAEASSQQLAARQELSISTSRAPGASFPSAERQTFHQQHTTSSSANVLPIIIAPVALVIVVICVMIYFRIRPFHRSNDCVDVNYMSREVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D263</accession>
    <name>A0A061D263_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766388.1">
        <property type="nucleotide sequence ID" value="XM_012910934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D263"/>
    <dbReference type="STRING" id="5866.A0A061D263"/>
    <dbReference type="GeneID" id="24562743"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105110"/>
    <dbReference type="OMA" id="FDQRCRE"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58602" checksum="58A3275242285DFB" modified="2014-09-03" version="1">MVLPPAASTGRAVKTKQVNLTTGIKILRSRGEFDAFLEAEKSNPSSELQEELGALTACVLHGQVSNITKTKHASEAARNRITVPSTAMHKDDAIEDLGFVLPKQYIRFMQNRHSQIGVKLSETVSVHYSLYNQDVQFVESFNARCPDTPLSLVEFCLLMDYFEKGSAKCPREKPFSYEIALLGARESGNAAPAFVLHEVHAYWSRRRADHALPLIRHLWPVTLMWESSAFPVFRPRTKEKMLLRRPRRTKVESILRLFRIIDGFRKVLKLLNKMRQRDDKKLMVAQLEVVLFDQRCREREDESYVCPFWRSILDNKRSRVLKKMRTESHKTESAADPLSSSVGRLQSLQLPNRYWTSYQLDDCTPDNKSYRYLRISRRIGRGGRVWIDRRYLYDRPFAYGRKHHRLFSLLSDDESGDDIESDYINVPNRTGSFNVYTNDRRLERHPGFACTYEAVHPYNTGGLAHYQLPEYLARQLEIIKLLEGILPRQGDSGVRRLRAPGNYEGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2G8</accession>
    <name>A0A061D2G8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766468.1">
        <property type="nucleotide sequence ID" value="XM_012911014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2G8"/>
    <dbReference type="GeneID" id="24562823"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105910"/>
    <dbReference type="OMA" id="YEVQCTH"/>
    <dbReference type="OrthoDB" id="361855at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599967" evidence="2">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="313" mass="34597" checksum="E995864CCAED0822" modified="2014-09-03" version="1">MKFATTIVVALISLLVSYSGAGDVEGIPAIAENAVGATASINESSNEASDVEEDPEEEENEEVVEDEDESDDAEEEEDEAEDSPEVARRKRIAGTLEFCLKDGDMTPVELINCASDILLSGNMSPPPAFSKCVGEYVICTGVKCASELSKTEYRGKHYSKVYECVGACIPQLIRCLSRKPDPGPDALVELLDKPTANKDLILTIIECLEGPPGKITIVAFVRCVNNRLHIHHRTRLDSIGFILGNFLTKAMFKFSLMEEEDIIERTAAFGDCFPMLLRNLVSMHEFSFSCKKRVFIEGYDDPDDDEFDDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2J9</accession>
    <name>A0A061D2J9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MORN repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0111110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766999.1">
        <property type="nucleotide sequence ID" value="XM_012911545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2J9"/>
    <dbReference type="STRING" id="5866.A0A061D2J9"/>
    <dbReference type="GeneID" id="24563354"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111110"/>
    <dbReference type="OMA" id="IEWPNGM"/>
    <dbReference type="OrthoDB" id="296831at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="275" mass="29826" checksum="99F11EF48FCD8137" modified="2014-09-03" version="1">MGLFSRLTKRFASKKQQNGREESASSLLSRTSTIQSRTQDLVCQRSLSPYIGSRDLGAVPSRPSAVAANWGCIEYDNGSEYLGWTLEGRRDGPGKIHNGEMVYDGQWQCDLPHGSGLFANGDETIYEGNWENGLPHGHGVALFPDGFTYVGEWSDGVPCGEGKLVADEGRVYSGTFSNGLPNGEGVLVTYNGVRVMCHFDDGVPFGLGEIEWPNGMRYVGTIIEGLPHGLGRLTDESSVTLGLWKCGVLETRLKAHEALPDALRDDPAVSYLASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2W3</accession>
    <name>A0A061D2W3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0201100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767139.1">
        <property type="nucleotide sequence ID" value="XM_012911685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2W3"/>
    <dbReference type="STRING" id="5866.A0A061D2W3"/>
    <dbReference type="GeneID" id="24563494"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201100"/>
    <dbReference type="OMA" id="LANRFEF"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595721" evidence="3">
        <location>
            <begin position="18"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="709" mass="80850" checksum="EB1B29405061106A" modified="2014-09-03" version="1">MLIVWVAIVCSFNPVGAWRSERGLRDRAETHETKGETKANDKTTGSTSVHHGDKHVDDTYTELNEALKGNMRQKVDAAIASSAIQSQPRGLPVSVNGTSSEKRDDIVYQPAKGFLNTAYFNTLLVIFAILVLVLTLVADIEMRIQSKDEFMRQAFDNCVRQVALMSFVTLSLYIAMHTDLAKRLDELFVRDSKHLEVFDALMQISFFLFCGFFLYCIYIGIVVSRWTKFMRKADEADVLTSAKEFDFVKGSLFSWNRTAIDKARYMVNRMEFGDAVKQRGYSDVGGCYFMDYLRASLIQIAMTLIRISRVSLFVALVVLVALRFIGPVHIMRTIHILSSLNTAAVVALAWRIWYIESHLYPPELSQYMLLKLNVSDVGEALQPTYKGDNNEYTPSNIVQYWICGDTAINAHENLFWLKQHGPVVLHKAFEALLFCHLMILSVWLYCLKNNASAITEDYDAAAPIVGTLIVALLAPSMLYSLVIVTRCGNLIDFELLEKVLTSHKNENAKNALQLIDSLALEAIIFALEKGADDQWRKLLAKQKALPDAINNQLMSHWNSMKNGKDEIKFSALLKYFQSQWGNFRSCNQQRMKDFVKQFMHNDPKTMNCQEFMVFGYAIKSMILTPLEEEYQIALFEDKFEIPWRSPCGIDLNNFDAIITKLNIKWIKSSQRHFLEFIAGGAVEGISPHYLIRQLDNFQQACQKNYFSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D325</accession>
    <name>A0A061D325_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein P22H7.02c, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0201750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767204.1">
        <property type="nucleotide sequence ID" value="XM_012911750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D325"/>
    <dbReference type="STRING" id="5866.A0A061D325"/>
    <dbReference type="GeneID" id="24563559"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201750"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="197"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="421"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="547"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="643"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="729" mass="80740" checksum="AC33A69F13E7565A" modified="2014-09-03" version="1">MRVGSNTRVIIKNLPLSLDEKGVERLISDKCKELGLELTDCKLLCKNATNPKAKNAKNAGGKEAAVSRGLCFVGFADEKDATKFKEYYDGTYFRACKVTIEFSRPPPRTLPEGSDEPKKTERVVAKSKRDCGDGEVATTLVKQVRKYTKAGVSGERKHTVFEDNDAQSDSETGGSQTHDPEPPSDADEQEESTDNLDRVILFNLPYNVTEAAIRELCRPFGPITDIHLPLNRQNDADSDGGKLTKGYCYVSWVFPSDAVKFRDAKNRTIFCGRIMHVNLAKPKDNGSSGEAATYEEFSRRFARRNTEKSSYKREMQKKKLANAENATIWNTLHIDINATISAVSRQLELDKRDIVDEANAAVNVALSETLVLNKLTKWLDEQGVDYQQFQVSKSAETKDQDAGKDADSTENEVKRVTRSDDTLIVKNLPSDADEADLVEKFAKYGQLLRLAIAPYAVMGIVQYLEPKAAQAAFRGLAYTPYLGLPLYLEWAPVKLIREGAPVPALATKKKPAGKSAVEQPRGSEPPAAGDLSQEAEAEDDAEVSTNVSIYLKNLNFKTRDDALKNHFGSCRGYVSSKVVMKDNATLSRGFGFVEFDSLANAKAAIRAKTGLLIDGKVIEMSIAKRAEKPPAEIAESRILEATNKIIVKNLAFQATRQDLYKMFSYYGNVKSVRIPKSLKSNNRGFAFVEFLSKQESARAVEALQHTHLYGRHLVLEFAEEDPAEGQLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D394</accession>
    <name>A0A061D394_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0203740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767402.1">
        <property type="nucleotide sequence ID" value="XM_012911948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D394"/>
    <dbReference type="STRING" id="5866.A0A061D394"/>
    <dbReference type="GeneID" id="24563757"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203740"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="101"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="9">
        <location>
            <begin position="280"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="346" mass="37835" checksum="53141BFF42A3266D" modified="2014-09-03" version="1">MVCKELAIPQENTLVAVTDSMSANPQRLECLLTKGLLQRDIDLLKEAGFSTLECVAYAPAKMLLDVKGLSEQKVEKIKLACKELCHLGFCSATDYLEARENLIKFTTGSTALDALLQGGVETGNITEIFGEFKTGKTQLCHTLAVTCQLPVEQSGGEGKCLWIDTEGTFRPERIVAIAKRFGLSPANCLENIAYAKAYNTDHQLELLIEAANIMAQTRFALLIVDSATALYRSDYSGRGELANRQMHLCRFLRALQRIADTFGVAVVISNQVLSKVDNMASFYGGNDKMPVGGNIIAHASQTRLFLRKSRGDSRICKIYDSPSLPEGEAVFGITEGGIDDYTDKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3P9</accession>
    <name>A0A061D3P9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767394.1">
        <property type="nucleotide sequence ID" value="XM_012911940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3P9"/>
    <dbReference type="STRING" id="5866.A0A061D3P9"/>
    <dbReference type="GeneID" id="24563749"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203660"/>
    <dbReference type="OMA" id="WLDLWSK"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="28597" checksum="033557A792A033B3" modified="2014-09-03" version="1">MGNGKLYEILGVESSASTRDIVKAYRIAALKTHPDKLAGLSEEEREKASASFVQLQHAYEILKDEERRKQYDDFGSVTEGWEGEEQAAFAAAYEYYKGPISSEDIDDFCATYKHSQAEEEDLLEYYKKHDGDIIDILSYIPLSEAGDLDRFVKFYQDKIESKDLESTKRFAKTSSAKSVKEIKQKYKKSMQRESKRAKSSGSFEELTAQILVSAAAKKPHEPQANRKKRQNDFTSLIGDLEKKYGAKKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3R3</accession>
    <name>A0A061D3R3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767527.1">
        <property type="nucleotide sequence ID" value="XM_012912073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3R3"/>
    <dbReference type="GeneID" id="24563882"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204990"/>
    <dbReference type="OMA" id="FCISANN"/>
    <dbReference type="OrthoDB" id="363220at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="23543" checksum="962B131C476A21E2" modified="2014-09-03" version="1">MNVLDGGCFVALCDSLVAVDLRLVEELTCRDLLARSHPENDAERVNACVITPTTAGLWYVYALTESSGCDIDETRVAALVCISASVLDPALVSTSYLLELPWKELAGDESHWYTNKLQIACGTVGFLCMESIRRCAKAHGLTAENNEAFYEYIRSWANAMCQATTTSSKICLSNLPNGPIGAVSSVGICDNGTYYCSVLRDDVTGEVSGIKVMFPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3T3</accession>
    <name>A0A061D3T3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766908.1">
        <property type="nucleotide sequence ID" value="XM_012911454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3T3"/>
    <dbReference type="STRING" id="5866.A0A061D3T3"/>
    <dbReference type="GeneID" id="24563263"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110200"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="564" mass="63844" checksum="2BA0CF60EEB6D45C" modified="2014-09-03" version="1">MLMKLKKPMQLKKVDERLALDSKYKYAIERLRKQNLQRQADAKALEKRFEEATRKTDERRIQEEAERREEQKEEERKMRLHEQAYYDYANSFDGKPAPDPTDFILMNHEAINRRRVYKEEEERERKKDLALKKVLDAAARDINIPIQMPRNTFVRPIGELDGHAPAIVNHVDGSSLTSDSKGGANVPTSQHVTPPRPPMPDFKGTVISDSNLHSSPIPTEYLEPPPPGGMEIADAYIPPKIPEQFEIDIHVPKLKLPDNDLNFDLTFDDDSTHIKTDTLPDPVDPPFPAVSFNIAPPDVEQSMPPPQDFDPEIIHRPELKMCISSWATSTPTPGSTDIPETERFPAEAPSTVRDMLQWLAGLKHEKHHDTLKQCINKAFGGPHSDPLQRALHINHTNIRPNDVFDILQLTATFASSVLNSIAPNWRAHVSSKPVQPKPSDQSDEPDCCALICQLRDYVYACHYQLEFLKAQCGRDKQSGGWKSCEYGSDSKTSSPLQAFLTDGWDSTFKTHLFDPCNLCHKSRVRMGFKKEDLHKDSKAGTVLSSILSPSCGGEDHDALVDTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D496</accession>
    <name>A0A061D496_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0200240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767053.1">
        <property type="nucleotide sequence ID" value="XM_012911599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D496"/>
    <dbReference type="STRING" id="5866.A0A061D496"/>
    <dbReference type="GeneID" id="24563408"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200240"/>
    <dbReference type="OMA" id="FKKNDGW"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="7">
        <location>
            <begin position="113"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="317" mass="36658" checksum="2EC8CC94151418CD" modified="2014-09-03" version="1">MTALVDSEADANIGATDDGQNPEYIEAPGDASGSDFEDVDTDGEDPEGKPVRLSKSQKKALAKARYREWRREKRHRNRRETRKREQQARSELLSGMTEEERSAFFLREKQMAEEKKLQQQAFIQDAYENGMPICINCTFHEFMNEKMQESKSLARQIAGMYSKIKKNEAKVKLIITGMSKDTVLYKHMQFFNVDAWKVHIHSQNYWELFDTQNVVVLTPDAEECIEEVEHDKVYIIGGLVDVNVKKKTTLTQAKERGVTAMALPIKKYFPNCKKRVLNVCAVFEILIMRANNSTWEEAFQTWIPTRARTDDTKQLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4C3</accession>
    <name>A0A061D4C3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer capsid glycoprotein VP7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205820</name>
        <name evidence="2" type="ORF">BBBOND_0205860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767610.1">
        <property type="nucleotide sequence ID" value="XM_012912156.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767614.1">
        <property type="nucleotide sequence ID" value="XM_012912160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4C3"/>
    <dbReference type="GeneID" id="24563965"/>
    <dbReference type="GeneID" id="24563969"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205820"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205860"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="286" mass="32174" checksum="E00680C5BA3B9C31" modified="2014-09-03" version="1">MSLINKSDEVATVTTPHLYNDFEKSGKWVVARYFNGLALSPINGECRCVDAETGQLKAKIEIRMRTDYVCDIASKIFRNRMLPITGPWCSVVLHPGSTLTIKFPIQAISSASTDDTPRTSFSQLPYIYDYETKFWPKDLIKLRQLVASYDVDIYDEILYGNAIAGDALALDVSQMARGEVTLKYHLDEPLALRSGLNSFYSHWTLISRNDYVPDNISAVVKVSLAFTHQYGILGCDRRRPSVFDVGLSKNFCLPKSMGFGIGDLYECSYDIMRDVRKVGIRCGSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D576</accession>
    <name>A0A061D576_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767383.1">
        <property type="nucleotide sequence ID" value="XM_012911929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D576"/>
    <dbReference type="GeneID" id="24563738"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203540"/>
    <dbReference type="OMA" id="YVSQQRW"/>
    <dbReference type="OrthoDB" id="365342at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="973" mass="106233" checksum="7A7EF855FA18E309" modified="2014-09-03" version="1">MSCTTRSSASSRGEYTTHSFLFAFHVKELTLDPNVRAHARVKCARLLWTLSPRVCERNPWSSNGFGELPTGSTRMSDTLDIDSVVSNNVDTAFALLRCHQSGDHSTIAQSGTLAIDVVDDSTNLCLASASLSLRVLDVTPSIVLKNVRLLDSRGLQVGGLELCYVSQQRWVKVNKRKLSFLNSQRSSCVKSVVETSANYATSALEGRKESTPNGNGDSGFQGLNDGADEFVLLFWNSTSSSFVKAHPNDYQLHLMRNFIRAPFCGGSSVEDTSNDDHSSVAASVKVDSVGLPNNPGSVVSSARSDRRSDVLQFPDLQCANPAAPGFTSSSEFASDFGDDEGTCRSDMSLSSEPGSARLYDYLSRQGHIIRSQLTRQLSVDAMSTSSWTSCTRTAPSLSKQVPDVRRHAQDHSAATPFSMTPPSRSLADLSMDMLSDISSVVNSMDDGAMLSDFDMSVTSGFRERVVLRHVDARASPHWNVHRGLAEHSHGFKAGEIGARAAGSYANTAAVSFENPMRQKTQSLGECKAQMDMDGFAIPGFAPENRDGSSGGVCLHASVSTADMPSIGADYGDLGPSDSINWRPEDAIDSGNPITPFRGDGSSNGRQCSVYLRDTESHFDIVEDAHCTVVIEDATPKAVPNEMIDVDRFYTDDNYLFGALHAAGNVGSDCSSTINNFYTAADGVELGTNESCMVREPTVSPCKPFKNSLLSAVYNAITADLSSLSVSDLGMDHAECSLDVMSEALSDARALQVQQERLSNELLMNFFLQLLHCYSQKGLVQVMLMEEVVQKHLSAADLMTFLPADYNPTVIRVALDILVRQLGIALPPGRPDESQKGTEYVDPPPAASTWKDQVLRNASMRDSTGGGRPSDVFCRLSECETYSDVSYVEDSFQPTKELEHRQLVMRQFHAALQEMHQHIMAMDMRKLVYISRLHSKPIKKRGCLMTLLAIKIVLYRFFCGRRKLPVNNSHVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5B3</accession>
    <name>A0A061D5B3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0203850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767413.1">
        <property type="nucleotide sequence ID" value="XM_012911959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5B3"/>
    <dbReference type="STRING" id="5866.A0A061D5B3"/>
    <dbReference type="GeneID" id="24563768"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203850"/>
    <dbReference type="OMA" id="INVSYNC"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="139"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="588"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="720" mass="79762" checksum="35E2E9ACBCF0AFD5" modified="2014-09-03" version="1">MSQPSSEDCKRRKKDSSAATMEPGQCGTPASGGEPDAMNTAEEFFPQFDRSVERDLLLLGKSYDVAAREGHRYHINSLAEYQEMYRRSMADPEGFWGEMARSELRWMHPFHRVFSGGFEAADFSWFLGGKLNACDNCVDRWAEERPNVAAIIFEGDDPKDNRTVTFYELRQNVCRVANVLKRHGVRKGDTVTLYMPSVPELAFAMLACARIGAVHNVVFGGFSAASVGERIRDSNSRIVVTVDEATRGGKRIHMKNIVDEALRDCPDVTRCLVYSKTGDDAYFVKGRDVWLDDALPRERPYCPPETMDSEDTLFILYTSGSTGKPKGVAHTTAGYLLYAIATTKYIFDTRQGDIFGCMADLGWITGHTYVVYGPLLNGVTTFLFASLPNYPDPGRYWRIIEQYRITQFYTAPTAIRLLMRYGDEFPARYDLSSARILGSVGEPINPEAWLWYYNVVGRGRSTVVDTYWQTETGGIVIAPIPGAIPTKAGSATLPFFGIEVGLVDAKTGREIIGNGTSGLLVLRRPWPGLFRTLAGNHQRGLDVYFAKVPGCYLTGDAAYRDDDGYIWINGRVDDTLNVSGHRIGSADIEHALVQVDYVAEAAAVAFPHPIKGQAIFCFVTLKDSCTVTAEQMVQELRLSVRRLVGPFATPDIITATPNMPKTRSGKIMRRILRKLVSNQAEDLGDISTLADPSVVEGLVGICREALDTYAESLKASLAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5C5</accession>
    <name>A0A061D5C5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tubulin-specific chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0209120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767944.1">
        <property type="nucleotide sequence ID" value="XM_012912490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5C5"/>
    <dbReference type="STRING" id="5866.A0A061D5C5"/>
    <dbReference type="GeneID" id="24564299"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209120"/>
    <dbReference type="OMA" id="DQYEQRT"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="30470" checksum="DDFDAA36E8F7E5FC" modified="2014-09-03" version="1">MEFRHRIIKVDLHHSVLTDRRWPEIRIDNCMTVGALKEKLYSNTGTHPASMSLYAYRPGDMKRTQIHLDNDSCELHQYGVDDGYVIYILAAQHSHASAPAPDAGGAADCPLKVTNPRLHRHYAEQMERCRETGDESNFEAYRMSEEEYAQRGKGLREFISRMREQCRARDADTEHAPTKSIEVLRQEYPLGARCSISPSDLRGVVRFVGNVKRDILIGIELDEPMGNTDGSVDGVRYFTARGPSYGIFRPYEQVTVGDFPEVDPFEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5E4</accession>
    <name>A0A061D5E4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-strand binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0104980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766375.1">
        <property type="nucleotide sequence ID" value="XM_012910921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5E4"/>
    <dbReference type="STRING" id="5866.A0A061D5E4"/>
    <dbReference type="GeneID" id="24562730"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104980"/>
    <dbReference type="OMA" id="IGFIDQP"/>
    <dbReference type="OrthoDB" id="363748at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600621" evidence="3">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="239" mass="26234" checksum="E7CC42F83AD3CA07" modified="2014-09-03" version="1">MGMFELWKRKGRVLPLFCMVALLAHGNCLRLSNSSVCTAFLASSMPIRGSVQCMKSQEDELGGMSPADDEYYKHDAGGYFMDDAPRAPEGMSPTLNTVTLCGRIGFIDQPVSLGNGNKALRLSIATNDVGLSVWFNSLKRGRMGAVRTSWHKVVIYGQGNVDYIQSRARVGERALVVGALSYYTPQTPDGMPYRAKIAEVAVRQRWSGHTFILMPRTSQLGDDYANHPVDGVSDSYSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5H9</accession>
    <name>A0A061D5H9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XPG N-terminal domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0204400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767468.1">
        <property type="nucleotide sequence ID" value="XM_012912014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5H9"/>
    <dbReference type="STRING" id="5866.A0A061D5H9"/>
    <dbReference type="GeneID" id="24563823"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204400"/>
    <dbReference type="OMA" id="RFYQTKV"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="296"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="484"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="80260" checksum="CA4E626D187F1240" modified="2014-09-03" version="1">MRVRNFNIYLREQRLLRQGDLSVLRGMRVGIDAVYFFRSLKGICDPLSEVGGSLPPTFVSVVEENVEHLERLGIQPLFVFEGMQSKSHVLLSAQLMTLSVAEGWLAYARGDIQNAIGKFLQNSLIFSEDMIQLLIHLLRSKGKDTIRCPYFSAAQLSYFCAENVVDAVLGPPSLMLFGIPRCIISVDFPKDSFEWVELKEVLARLDITAPQLVDVCLLAGTEHCLSFPSQNAFSFGNCVEMIKQGPIAKHLCQLPQRDGITEYVDGYCVTKALITYPLILDKKGSVRPLQKGAKVPMDYHKLVGTRIPQAIYHLLGQGLIGPKIPFALATGEWVDDFCLNDSIELRELIQDSREYKCRALGLAVFKLDAAYQARQIRFQGHVAFIKGHPPIKQNSIAVIPNTCSTRMLSQQAMGDFCAEMARQNRDKVDVEFMLTWHLRLSSKLLKEVTPSMASEAIANMISVPSGVQRPSDLDIYNANLWCIMLDNLGYFSRMGSATAFGKVLANAGLGLTGLLFMETLKFGLFTGEEFEVPSDVVVPHEVLSKYRGSLPQDVFEVVNLVSRVACLHPATVDNGHWRGEIDYMISSYICNLKVLRRSINYLIEGSVILMGGMVSGGEAPYLYESNCFMANFVKWLLTYDQEHHDGGSNIVAAAKSKFPSIVDVQKNLQEFADFWAKISAVVHELQKYVHIEALGTFDRGTKMLQAAFVHFGVSVALHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5M6</accession>
    <name>A0A061D5M6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767483.1">
        <property type="nucleotide sequence ID" value="XM_012912029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5M6"/>
    <dbReference type="GeneID" id="24563838"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204550"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600076" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="6957" checksum="6D7D23236BC429DF" modified="2014-09-03" version="1">MVFVLITLTLLVHAVITRVPQFSIPKNERAVSHIVINSPIFYYRKWLTVLYINSTMFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5T6</accession>
    <name>A0A061D5T6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0212230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768267.1">
        <property type="nucleotide sequence ID" value="XM_012912813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5T6"/>
    <dbReference type="GeneID" id="24564622"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212230"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="6970" checksum="E36CA8AEAA9BF1E8" modified="2014-09-03" version="1">MTDGFLDIDTRTQIPRYVYCHITLNNTLDNANIRRQVVQLRNAEESYRKHGSSGGKDHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Y7</accession>
    <name>A0A061D5Y7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0300310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768312.1">
        <property type="nucleotide sequence ID" value="XM_012912858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Y7"/>
    <dbReference type="STRING" id="5866.A0A061D5Y7"/>
    <dbReference type="GeneID" id="24564667"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300310"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="298" mass="33458" checksum="6312FBF7E7EF07A4" modified="2014-09-03" version="1">MKNDKLRCFRVFRSGIPDMSTPVMLGIDEAGRGPVLGPMVYGGFVCPIGEACNNMLKDEIGVNDSKKLTADARVSKFRQLNTPSKPFAVCAEVVTPKFISYKMLQRYVLSIQQYIPRRDSYNLNKISHDAAISLIRHFISQGFNLKEVYVDAVGSTGVYEAKLSALFPGIRCVVATKADSKFPVVSAASIVAKVIRDNMVESWLYDKSEHVEVGSGYPSDPTTVRFLSRSLDKVFGFSTFVRTSWATAKNILEDSNVATPFEWYEINTKDNEQEAERLKAIRETEWPPFRTLQNITQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D614</accession>
    <name>A0A061D614_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RFTS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0206150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767643.1">
        <property type="nucleotide sequence ID" value="XM_012912189.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D614"/>
    <dbReference type="GeneID" id="24563998"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206150"/>
    <dbReference type="OMA" id="DQRNDEF"/>
    <dbReference type="OrthoDB" id="340714at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022702">
        <property type="entry name" value="Cytosine_MeTrfase1_RFD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12047">
        <property type="entry name" value="DNMT1-RFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFTS" evidence="4">
        <location>
            <begin position="181"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1451"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1255"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1322"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1477"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1506"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2095" mass="235394" checksum="CB658C8BFDA41459" modified="2014-09-03" version="1">MAHAAGGATFSESAAVDSITQRLRSGLAWRSMLLQQVGVNRYCTYDPSTETAVTTMYETGGSSLGSQAEHLQSGEDIDCTYGVSSCNEAVLTRSHERYHGEAAIPSAFTFFQEDGTVIRYVDDFIIYSPACDKITPLDHLSRFGMGLWLMGKLKLVNSLYTASELSALMHPTLNEDLSSHDSSRGRQRRKCKVIGVRARILDFFIDYGCKPSDVPALYVISEHDVYYRLDKPAQRYVNYYVSFMLYYNLSTRITKEYQRDRNRRLHDIMAEIMAEGGSALTTWNEAMHVQGLTEADLIKVIEMIYRDCLHVHLFQSRNKESSYEQTQEMNAPSSIGSINSLQAYPPLDARDLYAGLDAPYTMLGASKVMGNSMLVSDINMEPAGLGTMYAPPDLAAANTGANTIGLLLCDLMAVLKEHRPFVFFDQSFVVPEFMSTARLTEKYLSTFQQLYDDPEMLQQKRQRNMPIPARPPLVDTKALIATSEVVRAHKMPKIGPQPKSAKASKTHKDGSATRVYRESKASKTAAAMDAIKVVVQAPPPVEIKSKVSGRIIKRNSKLADSEEVQLIVHEEPKPVVKRSVAAPEPDEAMRHRQQMLIDTEKQCNALALPDDFAYTCYNTSSDVSGDEAGRQPLALLNDCCVELNDARYYPRDIPLRLLRFYGADDILDIANVCRQFSASPSTAQPMLPRFTFAELEKSLLYTTSVDVYKPIEPSTFRFEPPQCLCSLVAKDQDWLPKFQRLDKRVNDLYVGLMRSLNDFSRYESYEYKVRMMRLLSPLSDKKKDAQERDIKASMPDYDTLSYFISTHGGCLYRGRFRHIIPEPEHPIPYINTARWNRRFKKVERLLAATKSYVYTNVDYEYLPEGVVISLNSRLEGVPMDLLSSHCREGADYRVIYPSDVFEVLPTFSKKMLVWQTEVLPEARERSDLINALNDRLRASSLALFTVDPVTPNKTEPVLGFGFKESISLLSAKVALNPMMLTEFTWPCLLRLYLFYAVYSCRRRYLYRLNSRSFGDARSTAMEDDDEDEEDDEPIDKEAPEGTKGESTTAKSNASLQATNNSEDDVDDEEEEDEAEGEGEAEAEEGTRVGRRRGLGAQRYSPYYEFEIQWYPDINRVKHMFKGTVSIEAVKVILEKLRVCSIFELEVRDRLTLLRWMGELLAYSPDAKRFIDQRNDEFFSLKAALVKSDVTQAPNVAASADGKAEDVDRSPDYETMALTNNVGAAVKSEKGGALITAEGKVGVKRRGRYKTKKNTEAASSQQLSNAKSHPDVKTESENVSNLSSNVQVKLESNDVDGVAIKEEPGAIAPGKHASAGDVKLEGDTQNPEGGVTNNSRENDSAVALVATIDTVKRKKPKEIMKELAELEERYVQRNVHLGRDRFYNDYYYFGGDLGCRIFVRTLPSARFTAQRTSIRSKQRRGASFGPEKFKFRIADYAKQLMEDRIFAVDAGTGKNKRKAAEESSTSEPQDDNKKAPDDSNTAPNPQEASSDPKNVGEVKEEVGTQMIKRRKPKGRKPKMAKPRLRRSREFFERQPTSFDTVIDYLNYLTTIPPRLSWGVMDTPWDIRMFIDRLSPLTSNERGLQAKLIQLEPEFNNLSLQPNGSVEAWRAPTPYGHLLISLSQGVKSFSSRIIEMSSTTLLRYGIMKSESPSHNDLMMHVKSEGDTRRGKATDAAVGGQPCNVCASNGRNLCGTNPAEMISVENNRLAQLIDSMTLDSLKCCCGDLATVASGMALILQLVVLCESAVSRYCDWLPWNEKRAMWLDKMDSMYRDVQRISAPVTANAGTGTVSARDCACASRGGSAALSDDEKLLLQSIEELGLWFQYVYVFNQPRLEALSKYQLRWTSVSAIEKPTLLCSHISTMCQGSVVYMFGGYREWLLSLNENKLFPRELLADMVKDYGSVPTEPNTASLLKALPSMEPVVPKETLEVHVESVWLFEVPECGRFARLVVRSVGYEKYDQEANPTCDSVVEGRLVPYLQSVYASAAEQGNDYGLDKAVEDGVDYVLRGESLVSKRFVVYAPLDCIERESEFMLPLTFLAGHMSPVWRNLMSCNWRGAPCKVRSMCYGAADLWRAVQIDAADQSEMVNLWEISPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6A1</accession>
    <name>A0A061D6A1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768269.1">
        <property type="nucleotide sequence ID" value="XM_012912815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6A1"/>
    <dbReference type="STRING" id="5866.A0A061D6A1"/>
    <dbReference type="GeneID" id="24564624"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212250"/>
    <dbReference type="OMA" id="CRYSVCC"/>
    <dbReference type="OrthoDB" id="366863at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="370" mass="40363" checksum="446CE4DCD17B444B" modified="2014-09-03" version="1">MAEMEGSTSCCGCGQPCHVKEGSLCCPKDCKRCEIKKCKEKQECECNDCNCGCKSAIKEGKQCKDSGCPSCVSLCKSVKVGEKCKCSICGCGCEGAFKQNKRCTDQDKPCDMCQKRCKNLEPGEECICNLCNCGCNGVNCQCCRWCNPDTTCGEHGDCDSEEIHDTNCPRGKCQQTPGDCSKVTCMCEKMGIDKRAGLCECLCKCGNQCPRILCDQKRGGVFNGQRGICSKSTKDTCTCECECNCNACGKYYGKDGKQVAVGGNDQMHSYVIGKCRFKCTNCGRLCDQDRCMIWIRVVVIGLIILASLFVMRAIFPEKFRAIMTKIRAAFASSPVHSGRSPSNLVGDRIPEESHIDRYSVISPGTYPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6L1</accession>
    <name>A0A061D6L1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766770.1">
        <property type="nucleotide sequence ID" value="XM_012911316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6L1"/>
    <dbReference type="GeneID" id="24563125"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108820"/>
    <dbReference type="OMA" id="HIARWAT"/>
    <dbReference type="OrthoDB" id="364757at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="477" mass="54507" checksum="616C74E5A29D50AA" modified="2014-09-03" version="1">MRHLIRIPGSKKVRNHFINAIPEEIATHPGISAAVVDIAEYNRLARMRGFREINSNSEMAYLIYTHRDIYKSLKFHPERHRARWDTVRFAVDRVLQKRMFRIGLGDGSPGSTHYTCEFDYSLTPLHDLTTNVYDEVGKLSLYLDLRKKYADTSKQYDVLSLANATPDFVVLGYRRCINYEEDLTVLVHRTRGSWVQIASLLTIKITKRDIGIQFTLDKDTSVYKSCHACLSSKAESVGFLHDEWRDCCVAPEMLDTHARLTFEDYLWEHHNVYANGMHPYQQSVLLLACGAVHHSSYSMEHKAGSPPDTNEGLDTYLGNDVVGPYLSLMKRMIVPRSMSESALPEALRGKEVTRVDYLLGLWLAYVSSVQKLRKELSAVRFEDYAECMTTDALVTYQQKAMVMSLTIIAVISLVSALISGYRFKSKQRQARLEIAKQEHVLHPETPRFYGATDVDTDSVPENNNLRRTPTWTEVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6M2</accession>
    <name>A0A061D6M2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766780.1">
        <property type="nucleotide sequence ID" value="XM_012911326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6M2"/>
    <dbReference type="STRING" id="5866.A0A061D6M2"/>
    <dbReference type="GeneID" id="24563135"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108920"/>
    <dbReference type="OMA" id="DVAEMYY"/>
    <dbReference type="OrthoDB" id="366026at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="838" mass="94541" checksum="2CBD3A448BCB7389" modified="2014-09-03" version="1">MRPRISRCIPPWEVHSRQAYQRRKSLAARACQPREALHVFFKRCTKAIADHRFGVHATRLLTDVVHKQELPSEENIGNAEVVHSASAATSQQPEEVVPSDTPAAEDATSLVDTTPLLEDVNVRLQYLGYVGLSRRDKRMLIDFVNRIAPCITTSGHALKFLNSMSCVVNVRCLPSSSVTGANIKLACREAFESLFRRLDRSADAYHVVASYLKLCAFYGDDMSNFSPVYHDMVEAVVSGDVFVTERQLDDLLFVYQRLAICDRRFMKYHSDRISRHFECFSDDQVCNFARYLVKSVHARARPLDIGATADYSREFDASDTMALLDGFDVASSSYARCLESQLPVCLHQYSYYNLVDLGEFYSLFNIQSSVRVRFSTELWKYLYTLRYGYPIKALVILSKLGLGDSATYGRLIRNIPMTLAFRWPLNLVSECLISLEWAKSSKIYVILAHYLSKNLSAQFNALNVARIFDSLCNKRVALLGLYQKVLRIQSLNPGWLGCEELLAVARYGKEVGFSLAGISGMLKVQDLDGMDYRKAITLLYVMENPDAALLKRCIQAIHNKDTSQCLEFDSLMQLLKACYRHKIWLCASPQLALEALRDVETVEAPVLLELLDLLSLAGPIGEPNLLARLEGYVEHVIADLPLRTAGRMLWLCFSLGVLPDSACFISLLRRFNHLYEPSYNEDHLLQVLGEALKRLKSQTVEVRTFLRHLEAFKDVSWRREPAEIGKIRAFQRNVGCKAFVSVFPFTADVEVDATALSDYVTRIGGSSLSLAEPCLQSRSSWCASSDIAGTVLLDLCGDPYVTVVERDGNERQALRFYYQLRGSLVGRPFAHLLDSSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6M5</accession>
    <name>A0A061D6M5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767858.1">
        <property type="nucleotide sequence ID" value="XM_012912404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6M5"/>
    <dbReference type="GeneID" id="24564213"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208260"/>
    <dbReference type="OrthoDB" id="361678at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="280" mass="31039" checksum="986475920F47A296" modified="2014-09-03" version="1">MNIHMRTQNVSPLSPVCATRSAIGHIASDVSRGRAEQHVDTGIIEKSKRTYAGYPSRQDDTCAEGGEKCSLFNGRIRRIKIDSLLKRPDELNLAIIHRTITDILDCGMTLESAQVDVITQMMLKCCDEDHVLALQTVCLVLLACAESLTESAVKKIGDIMGTATTATSATEQLALVDLYHCISSHHSYVMRQLSCGQRSYMQFLNEVRQYIRLKVPCDTDSKEIEDLRHTLNALNVEHYAAIAGHVYLPIVLSGTHMVIELSTESDLKCLNMEGAHPIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6R2</accession>
    <name>A0A061D6R2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768567.1">
        <property type="nucleotide sequence ID" value="XM_012913113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6R2"/>
    <dbReference type="GeneID" id="24564922"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302850"/>
    <dbReference type="OMA" id="ILIPNWT"/>
    <dbReference type="OrthoDB" id="360424at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="312" mass="35533" checksum="18C94361A8C76AD6" modified="2014-09-03" version="1">MAEVRVELLDLHSELKCSLFGLVCLITLIAFIYVLCRLAVSPSRMPRSELCVVLLSCSQLVFGIIFYFGDQHPFLHILNKAIKVVQAEIISWSCLDIMLANKKRRRRMAKGLMNFVTCCIALSLLYSYFNVYDHTIYLNAKVGIIMSALWCAMSVAVIYVACKIRRSLDVSKILKIDEEGTEQGQPDSGANLQNFLRDGGDLVESYSDTRYQHLLLLVVVEAIAAMGTLVWDVVLYYSVKQSMNGKGFELDMPVLKEVLYIATNTIVILIPNWTVFYVFYWVQRQNYSNISSTWDVNLNSMKFEVKEPPQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6U6</accession>
    <name>A0A061D6U6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0208810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767913.1">
        <property type="nucleotide sequence ID" value="XM_012912459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6U6"/>
    <dbReference type="STRING" id="5866.A0A061D6U6"/>
    <dbReference type="GeneID" id="24564268"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208810"/>
    <dbReference type="OMA" id="CDYIFLP"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="232"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="803" mass="91325" checksum="665CF3389F407B6C" modified="2014-09-03" version="1">MENDDGCQRSQRSKPNSNRLQHARSKLYDPRKGSAYTKLSKTHETKLRQLRENERAVSLSTVLRPLQSSRSCQSLCNDGSTSYVETSDSGSQDSASDSPTAFCPNDQRNPKSTARQSLYINSTAARRSGNVEEAAPTISLPLNLDDDKSVSRSSVSRAALPRRIRDMECKLRMPDDEPISVVKELQDTAGRSKTDSTSSKALSGSIAIESFRKSTLPSFRNTPQRPHSFSMLTFNVGLLEVRMFGIQMYQNPGYTEKRLKCVPNEIRKANADVVAFQEVYSNHHARYITQQLQDIYPYAARDDCLPVSEDFENLYDKNKKKKRGIGMFHSGLLFLSKFPILCAKFHAWDVVTHLEAMLANKGYMEIFVDIPSVGKIAFYNMHMASASVNPESVHIENVRNEEVKQILKRTEKACRLGFAPIIIGDLNAAPNNCASNYMSFLHSGWTDSYVLSRQKAKQKRWLGLKDRRIKKNDSTFESPLTSDESIGVENVFGDNKSQKPHLEKVTIMSNMPRSRSGGNMRHPHMGPREGSRWSRFVEYLSLPKGDRLRRAATSWKHSKTYRPRANSIRLRRIHTANRHRAPKSKKLAKLHKRLLKNKLSVRVKAPCLECKTDKAARTFRERCSALFRRSKSLWTGEPKPTTQTVAFTTARSRVAIDPSSVYFLVKNPSKQLKRPRVRRFYWWYRRRNFMDVTWDPKNPLNMHGPHAGCSGLRCDYIFLPPQHIAGILQGFAPSAGEILFREPIVMIDKVGSAYNCLCSAFTSMKKVMLVTLSDHYGLKITMVRKKTKPETSPPIMLRPSQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6X8</accession>
    <name>A0A061D6X8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766870.1">
        <property type="nucleotide sequence ID" value="XM_012911416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6X8"/>
    <dbReference type="GeneID" id="24563225"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109820"/>
    <dbReference type="OMA" id="MVIYEWV"/>
    <dbReference type="OrthoDB" id="364724at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600102" evidence="1">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="198" mass="22586" checksum="AEDF9A0F0C43079A" modified="2014-09-03" version="1">MRVPTSACLVVCSLVAGVRMVSGGQYAFTLPMYVKGFWGYDRYTGASTNHEYLSYFDVDVNNMMTNANKVVEDNFLEVINASSFNQVSHDAALNNEGSKMINKMWARDVINEIHSYKMQYIHQRYRSAAQQLLKVPVGNPAYQDIGFDEPLDKMVIYYWAYQLKQAYDDLMLNASKMHTKWGAIKNSINTTMPESEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D773</accession>
    <name>A0A061D773_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Maspardin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0304690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768752.1">
        <property type="nucleotide sequence ID" value="XM_012913298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D773"/>
    <dbReference type="GeneID" id="24565107"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304690"/>
    <dbReference type="OMA" id="NQHILAT"/>
    <dbReference type="OrthoDB" id="10264550at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026151">
        <property type="entry name" value="Maspardin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913">
        <property type="entry name" value="ACID CLUSTER PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913:SF0">
        <property type="entry name" value="MASPARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="374" mass="42149" checksum="08B9A18C6990F4FE" modified="2014-09-03" version="1">MNEGDVRSPTVECLSSLKSIQRDYARFKLENPVKRVFDPISELHWTYYEGATVKKPDGSDESLAELPCVVLLHGICGTAGCYFYVIEKLAKAGVRCISAQYPEYYSPDEWIEGLLHFLEYIKLSKPLVFASDLGGYLLQLFVEKYPESLSAIALCNSYRRTDCFSSSPELRGMYGRLFTVLPHVVLKNIFVEYYICPQDNVRARAKSPMVEQLAREFMANELNQLTASDLGGRISLQMSTDYVDDFCSRRMPPSKILIIETNNNNIPDELTEDMLEAYQDAKIAHMRDGGDFPYLTKPEEIVTYLMVHLTNVRALQSAQNITDAPVKSGGCSSLRDLYKFNIPRRSSESSHCSVIPAQPSWESDDATSPSLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D781</accession>
    <name>A0A061D781_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768579.1">
        <property type="nucleotide sequence ID" value="XM_012913125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D781"/>
    <dbReference type="GeneID" id="24564934"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302970"/>
    <dbReference type="OMA" id="KANIEYM"/>
    <dbReference type="OrthoDB" id="10513606at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="277" mass="29521" checksum="32AFD3321E2AAAED" modified="2014-09-03" version="1">MAINDAAQRRRRSWILVGAGFVGVAALITTIVLVAVFCGSEDPISERYKLTTFDAMGNKKVMDMTPDQFFQAMKENTAFMLGDDRVQSEALYGCILDMTKSLGDWKVAADEAAAKAKAEEAAAGEEQPAEVAPAEAPKETTGCCSTPEKVADTPQAPATMVEASSTGAPEKPVEMTESPAATPTSTAEPGIPTAPGDASGLRGTSTGAPVSLRRRIAYRIAERLAQRRDNREAVVTSGLGDYMWNSIAAIVEAIDSAVPLHLWRDTYEGDLDIDETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7A0</accession>
    <name>A0A061D7A0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766965.1">
        <property type="nucleotide sequence ID" value="XM_012911511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7A0"/>
    <dbReference type="GeneID" id="24563320"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110760"/>
    <dbReference type="OrthoDB" id="365966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600111" evidence="1">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="240" mass="27197" checksum="AEF5087B9C3C4703" modified="2014-09-03" version="1">MSSFVRRSFALIFFAAFIGAHLVFGDEHASANAHADVTKPSRCPKGADCAIINELDKRHIHLGTFDGLDRKPLVITVHKSNLKERRVYAVTALSEQSTGNEWMSIGILNEEEHKEVKGHHQNYYRKILTEKFMCDTMRFGQYAHGIETLSFISYNVKLTPEDLKRLKGYPEGSQYEIELSEDTQSMFNMPETDGPEYSKGSIMINPEVAEGKYYLDFAYGNPFGGPKMVCFKEVIVKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7A8</accession>
    <name>A0A061D7A8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766970.1">
        <property type="nucleotide sequence ID" value="XM_012911516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7A8"/>
    <dbReference type="GeneID" id="24563325"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110810"/>
    <dbReference type="OrthoDB" id="365966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600112" evidence="1">
        <location>
            <begin position="26"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="27781" checksum="F1D36605C32E70FF" modified="2014-09-03" version="1">MSSFVRRSFALIFFAAFIGARSAFGDDQASENPQPDITTSSHCPKGADCSFIGEFDRRHIHLGTYDGLDRKPLVITVHKSNLKERRVYAVTALSDVGTGNEWMSIGILNEEEHKEVKGHHQKYYKNILTEMFMKRTIRVGVSAHGIETLAFAPRDVTSINDDMRRLVRDEARVQSEALTHVDTTQDGKEVNIPPEFTSENRIEVSKGSIIIHPDAMEGKYYLDFAYGNPFGGPKMVCFKEVIVKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T4</accession>
    <name>A0A061D7T4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0306500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768932.1">
        <property type="nucleotide sequence ID" value="XM_012913478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7T4"/>
    <dbReference type="STRING" id="5866.A0A061D7T4"/>
    <dbReference type="GeneID" id="24565287"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306500"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000019">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="273" mass="30641" checksum="319A43E13BE6145B" modified="2014-09-03" version="1">MVGASPSCSPFRCSGRGIKKHMKRINAPSHWLLDKLSGRYAPKPSPGPHKSTECLPLMLLLRNRLKYALTYDEVKLIVMQKVVRVDGKVRTDITYPIGFMDVVSLDRTNEHFRLLYDTKGRFVPHKITAEEATYKLCRVKKTFIGPKEVGVAVTHDGRTIRCIHPDVKPGDSLRIDLETGSVIEFFKFEVGNLVMVTGGHNQGRVGTIVHKEKHPGSFDLIHVRDEVGNTFSTRSSNVFVIGVGTNNYVSLPKDRGIKKSIIEDRAQRLARAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z6</accession>
    <name>A0A061D7Z6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766011.1">
        <property type="nucleotide sequence ID" value="XM_012910557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z6"/>
    <dbReference type="GeneID" id="24562366"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101540"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="93" mass="10398" checksum="4BF20C00FF8F5DE1" modified="2014-09-03" version="1">MSTTPSKLLPIASDRWPGLCGEFIEKLLNLGVETGAIIATKNPNRVYLKKGLLNATRGRSLTHFVRFLGPTEKQHLKTMIHMECPVICPNRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D875</accession>
    <name>A0A061D875_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768919.1">
        <property type="nucleotide sequence ID" value="XM_012913465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D875"/>
    <dbReference type="GeneID" id="24565274"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306370"/>
    <dbReference type="OMA" id="NPEKRHL"/>
    <dbReference type="OrthoDB" id="359847at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="805" mass="91203" checksum="49C697EE308FF054" modified="2014-09-03" version="1">MGEPPLRPRSSRLGNADRRPGGNARKGRYEITGLDADAFARRTQFLRETYLDPKTRHAYQWTGNEKKMLALDWFHNPGLYNEWRPSETEDMASRLYSNLIFNYSHVAMVNVGSTVTICRLINEFVDIYGNYQLMFMVVRTETGELEPQDSLRVGLVWRGEQSSKTIEGKEALLYSAPKSEDFQWLAEGISFNLHSFSSDEFGCFETCDKCQNRKVEPRTKLCLPEIFFKAHVAGLEITSAIVDSRRNYLATVQKVDGTVHIIDITKVLQVTLEVVHKWKTVHEEYVRSFRELKNRLEGGPVSGGSAEGGDAAAPPEKPQRPRGHSASAKAVKHCTACLLNEEQLKTLDALRQQTMEFKLPYEPIKCVGLDVAAQPHKGVPFRRISNETCLTYIYSSIENLKVVVPVYVAAVGGSRICVWRIGDVNDGGTREPFMQLDFPEGCRPTDVTATLGIAKDYLGLVGDKFAHEPLIYATDDCGYLRLWTLGVSQCEASVQVDTNALLSVDVNRMYPNMVVIGVETGKIKIYNVWKQCMGVSGTPPEIDFVRMTTIPSYLPNEVYEYLRWYHPVVKVKWVNDTLVMAQYAEPLFARESANASTVAIWNMAKDIFDRNDAILCHRTWSQDLSYSWHLAARLVCLYGGHYASLGGVVSSDCRWSSEHGIIAISTDATGQMHVYKPGVWTWSDYDDALCLARFKGDADFHCKILDKVTKEHENLMKRNASDAMASADLRKNRAKFSDFMEIALRELELIRSDKALKNDFASLPTWLKRTLKLNTDCERLLKQIQKNLRDREITEHNTSGNRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8B9</accession>
    <name>A0A061D8B9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exportin 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0103020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766166.1">
        <property type="nucleotide sequence ID" value="XM_012910712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8B9"/>
    <dbReference type="STRING" id="5866.A0A061D8B9"/>
    <dbReference type="GeneID" id="24562521"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103020"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1187" mass="137277" checksum="A60CB448CE33B97E" modified="2014-09-03" version="1">MADPRVILDASRVFDKDMVAILDSVIDAMFDSGAGHNREAAHKLLEQFRTMPDSWKHVVAILSHSNNANTKFFALQVLQGCIQTRWNVLLPEDRLGIRRYVSEMVVNISMDDEACQRERHFLTKLNETLIQIVKREWPDRWEGFISEICRASQISQSLCENNMRLLNMLSEELFDFGEDHMQSRTVQRLTARMASDFREIFDVCIFVMHSAISNPDAVRISLIRQTLTCLAHFLKWIPVGYIFEQYTHNNVRVVLIDLLLDHFWDPVLYRVECTKCLTEIASLSLSSQEMQMFGPRVASMWPKIVNKMSMLPESSMSYEDTTQVVPSMRLFWETFYTQFSIFCTNFLKNFRESIVERDPNNQQSLLFVLERLVKITDINHEETFKICLDYWHLFVTSIAREVKDQQRRHAADRGIIITEDGTEEAFDRTTLNLNPSYDSGRLPMYRKVLVELQKVLIKRMAKPQEVYILYDADACEVTREYNPNTAEIALYNRMKTDLIILATLLQDDTERIMMDVLDHEMEIANTAGRRDTWDPTILNRLCYSVGSISGAMDEQVEKRFLVLIIKCLLNICEVKTATEDKAIVASNIMYVVGQYPRFLKQNWRFLYTVLNKLFEFMRETFPGVQQMACETFLKITNSCKRTIACQMVNDQLYLYELIHLRDPMTAVLDDKLVLWYYESVGNVISAVDVKLRDNIISQLMSRCNIEWQELLGYATNPNLLSTDPNVWRELQGMAIFDVDKTRAVIQILRVNNRVAKSTGFSYTTQLMLVYPGIIHLYNVYSCAIQHAVQTAGPGCLKHNNINLMHLVKRSILHLLETYISHLPNKLTRSLADSHVNIASSGRSGLTVEEDLAEMCSMEDLTVRNYNEVLKELVSSITSTVLAAYRNSMAETRDHEVICLVTTLIEKLGNNGCAVLPLIFEQIFDCTLDMVKQDFHSFPEHREQFYEMLQKSTKHCFEGILMLPSDRLRSYVMSLIWAFKHEHPAVAEKGLVVVREFLNNLMLLDRRQERNARHPGAMQVSAVLSFCQSYYYLLLKEILGVLTDTLHKSGFRLQTEILRVLIRFFECGTINDPGSELTRMHVMQFLVGVLGRSFATLHVKQIEAFVVDLFNFAGENIADQVDSLNFNGQTLKFQTHVKDFLLSLKEFAGSGEEFERIFEQDRQNAIQRARIIEERKMQLQAAKEVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8C6</accession>
    <name>A0A061D8C6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA / pantothenate metabolism flavoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769132.1">
        <property type="nucleotide sequence ID" value="XM_012913678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8C6"/>
    <dbReference type="STRING" id="5866.A0A061D8C6"/>
    <dbReference type="GeneID" id="24565487"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308500"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="171" mass="19548" checksum="E2AF8B4D7AFE92F0" modified="2014-09-03" version="1">MDLSDYKDKLVVLKFRTMWEYRNVIEQLSHDTKHLGANVIWFLTAAVMDFEIPDAQMPQNKVPSNAPMNITLMPTPKIRNIVRGIIGKAPTMCCFKLETDPNVLIQRAKVLLDEPTMADAVVANILDQRYDRVEIVFPDSTSKKIDAKKESIEKEIVDALIQVHHRKASRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F1</accession>
    <name>A0A061D8F1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766206.1">
        <property type="nucleotide sequence ID" value="XM_012910752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8F1"/>
    <dbReference type="STRING" id="5866.A0A061D8F1"/>
    <dbReference type="GeneID" id="24562561"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103365"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103365"/>
    <dbReference type="OMA" id="ACHLASY"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="349" mass="39382" checksum="989A6D5A98F5E08B" modified="2014-09-03" version="1">MVLTFHGLNASHSAFDNYCDVLKSCDFTVVTFDLYGHGLSDIPPYEVFGRQYSLDFFVDQALEVLAHLHLEDRKLSIMGISMGCCVAAAFCDRYPDLVEKMVLISPAGLIPRCPFSARLVKMFHCCIPCIPRCIRQRTIMKGTLQQELDDFTNDALWRILVTPNSTACMLGIVKRVPLWSGSQLYRRVGAMGKPTLVIFGEKDDVTPPTCADKFRKYFHNSQVIIFPGVGHQAAYVIPTAIASTCLAFLQLPSNSNVARYSRWLPFSEDGAYIRENERRIGRDADRSQEYVCEEQLGDMESDSTEVSSQRMAYCTPLLKQCAWSWKLTTPLTLVVVREYENSSNDTALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L3</accession>
    <name>A0A061D8L3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769237.1">
        <property type="nucleotide sequence ID" value="XM_012913783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L3"/>
    <dbReference type="STRING" id="5866.A0A061D8L3"/>
    <dbReference type="GeneID" id="24565592"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309540"/>
    <dbReference type="OMA" id="DNDTIHM"/>
    <dbReference type="OrthoDB" id="363857at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="27718" checksum="93E789506CB7623E" modified="2014-09-03" version="1">MRILRRVAPGRVRFPGSDVACVLSARAPGCVPAAIRSALGGRRALHTIESIRSRLATASAPLRVPERSNVRLVKDHAEFYSAVYSIPDRERVQSDDLVVSVFVSQQNTAALSVLDCVDRLAREYPGNKFLVIDADQVPRAAYDADLQQFPAALLSFGGDVYRRLVQETNGYPSGWQAVPQWELPSSGTVGQSSVECTLPEAFYTSVKREIESFGASFHGQAIATLKSRCGTHNYTHGIDTDNLNVKRVGWPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Q3</accession>
    <name>A0A061D8Q3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768508.1">
        <property type="nucleotide sequence ID" value="XM_012913054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Q3"/>
    <dbReference type="GeneID" id="24564863"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302260"/>
    <dbReference type="OMA" id="AHRETND"/>
    <dbReference type="OrthoDB" id="366406at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="236" mass="25274" checksum="C472670F15F66EB7" modified="2014-09-03" version="1">MQLPNSHASRGRGRQHNADTHQPRHVDNTRLKVYNIDDYEKLVSGAQENAFASQLEISPGTFLTNLATGTNRILGELAELSSGPFPTYNNQSKLAPYADALKQATAPVANPMPMQPAMQSPGVVPQVMPQPVVAMPQVAAMPPVAEAVPVVPVMQQPVQAMPAAMPVVQMQPQEPASPEKVNAILKDAFAAKSLPALPDRNFNLIIIGVVGVAVVVFIIAGIVVRIKQKKKSSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8V4</accession>
    <name>A0A061D8V4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0310440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769327.1">
        <property type="nucleotide sequence ID" value="XM_012913873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8V4"/>
    <dbReference type="GeneID" id="24565682"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310440"/>
    <dbReference type="OMA" id="IWLAPAR"/>
    <dbReference type="OrthoDB" id="430505at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="Cytochrome c oxidase subunit II-like, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9134" checksum="E390EF2509F23599" modified="2014-09-03" version="1">MSDGGASNGGSRKSLLQSIRSRLQIPSIKHFPARADAPQRWRTQMGGFDPATPYAEALINYHNHAATFMIFVVLTVIHTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D933</accession>
    <name>A0A061D933_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0311090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769392.1">
        <property type="nucleotide sequence ID" value="XM_012913938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D933"/>
    <dbReference type="STRING" id="5866.A0A061D933"/>
    <dbReference type="GeneID" id="24565747"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311090"/>
    <dbReference type="OMA" id="WSILHSE"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="307"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="428" mass="49170" checksum="9F991E8EF94CB6ED" modified="2014-09-03" version="1">MEPEALNKLIQKEGTVYDSVIPDFAEWVASGALDESSSEVLQRFEGMNSVERCDFIRDNELVARVLLNSTYATGPGLLRCYSLERLCDACRVDASTYAFLLNTLNDRDVFEIYYDIATHDSERKIIEKTMFLLSGFLACGKDRFTLEQVMSLLQSILASNTDAAPKLYAIANLIEEESYRESVFQESALIELIGSCLKREGAPNAQYKAVYCMWLFSRSQNYVEAMYDKGLVHALCDLFCSTKIEKIVRVGLLLLKNLFKSTRCLELIIDKNVSQTLTLLEYDKWRDIELYDNIQQLRASLESKTTKISNFERYVLEVDTGALKWSVLHSEKFWAVHFDKFEDDEFSVISKLVKLLYASEDPTTIAVACFDLGEFARLYHNGKTICQKFRVKDRVMELIGSRDREVAREAMLCAQKLMVQKWQQVWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9G7</accession>
    <name>A0A061D9G7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769492.1">
        <property type="nucleotide sequence ID" value="XM_012914038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9G7"/>
    <dbReference type="GeneID" id="24565847"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312090"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="78" mass="8245" checksum="D1E5555119FF60B1" modified="2014-09-03" version="1">MEELSVARIKVANLIINVNVVIVHVKINVQSTFASAVPGVVKNTLSANIAKTTEKNVEGLIQVIRVVKIGLPVGVMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K5</accession>
    <name>A0A061D9K5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768853.1">
        <property type="nucleotide sequence ID" value="XM_012913399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9K5"/>
    <dbReference type="GeneID" id="24565208"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305710"/>
    <dbReference type="OrthoDB" id="10623367at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="347" mass="37419" checksum="2AF95E36CED5E985" modified="2014-09-03" version="1">MINRFGNVVSEIMLELASSDSFTAYLDNTAAEREADDSSADANAGTRSINSRSTKLYESHVIADGAAGMQEVDAPTTPSEQHVMSTSGETVTDANECTVTRATSEAELLRAASKSMFDRGNLLPPPKAKQSTAENKPTDSAAEVAFKKAPQTAADESTETAARPTVKSPLKVPIPLRKGVAESEREAKAAPDTDKATTPEWTPESRINILTRAANRVRMISRVTQKRDEQFDLPTDAYGYVMNRSMSSASDQSLFRSPGHSGSINSTKDGFANRKGDAASAGYRCYGISRRAGIKLGTISSRYNRVNDALKALEVEDIGAVREAHFLQHTKTVSALWSRHGNVAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9P6</accession>
    <name>A0A061D9P6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30S RIBOSOMAL PROTEIN S10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0313140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769597.1">
        <property type="nucleotide sequence ID" value="XM_012914143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9P6"/>
    <dbReference type="STRING" id="5866.A0A061D9P6"/>
    <dbReference type="GeneID" id="24565952"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313140"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="5">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="612" mass="68248" checksum="3A31A2D7E67645F0" modified="2014-09-03" version="1">MILVLALCLAVASAVRLRERCGAGLASPCIAAVPAPQSSTLCAGRYINLARGVGSQCVGGEALCFAGAPALDGLPSFCHAGAAYGGSYEPRSRCEQQGGAKYRHSGYGAAVDTAATAHKQHRHGPVTSQLWAEGSVGSYYDVLSDDPIALEEQEDVDIDDDVDVEDDVDTDEDEPDSDVDLEDVDDLAGDFTATTVDSASTPPKAGATVPGITGRFGSPGFIAGTSSIAAAAQSKLRSFFNWRSSDSSSTDDRSDASVDSQTGDGDQRIPPRRERRPYHSSKPYGEADMLDLPYVLSRNVNMSLDRWPDNCFLRIRLESYYPFLLRFSADRLIKGIREHTNLRVGNVKAMPMRRKRWCLLSSPHVDKRSKDIYEIQQHVRFLDVFPAPKPARNSGPSAEGDGTGDSAHEGDNDSGMDADTSAEDIPEDAEGDEQRYDRERQQESDAMKFKGLLMVPLPNFVSFDYWFEEVHKHVKNRSIEKTFRRRIWVSKYFRHHYEKREKAELVDKLTSPELYSQIPLRHKRHPCDYFALQLGELRKLYDFVVRRKAEDEARERYGVPGPKFYDIDEVRFVPNEDDRRCGHLPDDADVDTEVSKQMAAMEKAENANARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q5</accession>
    <name>A0A061D9Q5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769444.1">
        <property type="nucleotide sequence ID" value="XM_012913990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q5"/>
    <dbReference type="GeneID" id="24565799"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311610"/>
    <dbReference type="OMA" id="SECVLAH"/>
    <dbReference type="OrthoDB" id="363663at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="584" mass="64743" checksum="5860C33F6362D75D" modified="2014-09-03" version="1">MVLLTDYNLLIESIYSHRSECVLAHLQSGCFFETDLRGLFRGDEVGVDRRIKRHLSAPCIFPSVQSVIPAYARTTALSVCRDSCAGVYHDLETGKCISRISRSVYSNRVPSGITDLGGTCTHLASATDSSSPLVFLSTALGDINVIDLRVGVKGEFGHPVMSLSRCHSGAISCMYNFRGFSFSLVSGGYEDGKLNFFDLRFPYDHVKSPYVERPMPLRSFEMHLRNQTKYVDMDETDQQILKHMKLGRLTSMAVSHDERLIALANGQSEIVICSAHEDVRILKMGFLSAKDDYATSIQFGPHDMDLYCSTYDLIAGIERCKRYLPGASAVNSDAPYPHPYNFVMWPMLNFMSNDWVTSSIEQFGYRDDFELVEDTQTSSLFGASAGMVPARGDAHADVRDTEDSKSDDERDQLSRHSSVVGDHETQVVSDEDETDGESGDDFSSPMSFLNVTRGRDAEMRHRSFRNHRPGVLHPLIFTICNDYAVSTGGCEAGTATVDVWDPQNQQLICSASTPETRNVRFEHICSGDDGVVLLSGTFERSVDRIPLTSEDYGHINKCVCVMKPISREVLIAEGASSVLNCSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9T1</accession>
    <name>A0A061D9T1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769464.1">
        <property type="nucleotide sequence ID" value="XM_012914010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9T1"/>
    <dbReference type="GeneID" id="24565819"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311810"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="301" mass="32967" checksum="3EBF415E28C6614D" modified="2014-09-03" version="1">MAERTEEASGKNQCGCGKTECTHTAKYGVCCDRTCKVYKAGCPPGCEGCKVKCKAKGKCQCCTPRCGCEADCYEKGDGTCKGIGTCTRCNARCKQDNKCLCHFCSCGIHCNGVICSCCSWCDPENCSGKECNGFVIGRCKDKYPDTTGCRGHVKYDIYDKDGKYGALYNRDAENVIPCDRKPHPGKPCTGKNCNWLSGVRDVNGNCVIKCTYCGKLCGQDNFRRCCTIAIPLVITVLAFLIFRFMLPEKFHAIMTKIRATFASSPRHSARSFSNLVGDKIPQEMNTDRYPAVPPRAYAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9V5</accession>
    <name>A0A061D9V5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0313930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769677.1">
        <property type="nucleotide sequence ID" value="XM_012914223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566032"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313930"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1648"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1546"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1710" mass="190931" checksum="452D9EAFB729FF59" modified="2014-09-03" version="1">MGFLSSIITEVKKNTNLTIYNNNLETILNSIKHAKYNRKNFDSSIAFVSQGIQAWVRGVEEKNKAVMTPLENLEKTLEGHASVDMSGELIIDQLSTWRGFTALYLQEAMDSYEALNGIDDKLKKELSPKLDLIKQVVQHFWNSVNDAGVISSVEALDNNFTVIPQKLNKHIETEIQAAKQTLHQHHGSIESRINNHKRTTQSQIEIIRKAVKDAQKLIQDLLGDKGLNYTNRYKNNITIKIGELKSKVEEFAKNDGPKTALLQQFEVAQSNVSTLEKDVQKDLLLLRQRIEGLRRDVSTFVQTELAELAAEKQKLERITNDSGSSQNGNIDRLFVTHIQERLSTLISAVRTKIGEVGKDFGNAGSSKRLEDIFNCLEERVAGIKAKVGDTQPPGYPASDSIYYNWKRLKMQIESLVESIYKIDGRTRSGKLGEIIETLGTYATKIGTNMDKAEEGHSTVEKWAKEILDNEGVKRDISYYVKDRTMNNTVTTMVNAIMKQIKEVVKKVNGNKPRSGDTVQAILRGVYEYLKKVADAVGDKANSANIDTFITEIKREAKLQSADSTDNIYVHAFKAAVKTVLQYVSGAARNLATVFESLANSDAKISNVDDATQKAASIITKLGDKEGAGKQPGDGITKALKEATPKIGTLHGHLTKAAKTPGSNGVIPVRDLDNAIDHVKKEVDGLLGTFKANVTNKLGAAVDDFDTEAREKIQDAADTAIDQAVNVFGTGDIKVSSLMHQFESTQKSLTSAVDKIQEELEKLKNVPEVIRQAEAHADGLMEELKNKITAIKDTIDPITSLIGAAEKTLTKTVESIERALQAARDTSNRKLQDLKVDLQKQVNDAFNVLEEHVQKMFSDQRKTNFLSLRECITDQLPKIQQIIEHDFSTGLKGLMNKLSDTFEIHPISPSSIDFYIYTSHVKNFCHNFFHELSEQDDVSPYSTTMEPVTSSLDNLLDTIFDAKHFSAAVSSNLAELQTQLTALTPTQFAEASPLLNGVRAGVTAFHGELAKQYVSRYSGETFGANLEEKGKLTAYGTKLSKLFLTVVSTLRSSLASLRRGSRNLSGQQTTAFSDLGRLVADQGYDVCDSTTEQNGEVKRHLTGKGIQMSLAGNDYEHVYHTDNNVRRPLENMYIYLNDYYKIGHIATSSSKRRPCSIYEMLCWLSGLPCNDVYEDLWRDAVSELFVDPKNQPTENGDIPVTVVSEQPLQAYPHPIECNEAQRAVKRLCSRAYDVLSEIIGYGDAYTIYAVDFCNNSLNLHYPTDAASCLELLMDILRRLFPVFRFLHSQCKLETHHIGWSNCLYGRDISTGKSHCDKHPDDKQTDCLPRSPLQSYLSDTLPGHLPHNLTAMGCKSVCSNCPKGVPGQPCLTPLGFRGFSGSTKTGKELGEVLTKFFDNSNIISLFGLMPKPPSTLPEHFEFASALVRSWNEKIAPRHLTWLTDAVTKQSVKLHDVPTEFTDALRKAYGSSRNTHDHSTATSPDVSSLSMTKPCLFAPKDNIYCAPYLQSLCRDSYYYLAKKHSATYLSWALYLPWVFWNSLNNLYIGFCSIACQDWGCQGCLRGDDCKRGQHGANYNCKCGSIVNCRGVSSTFYAYGFTFGESSILLDTDGIRYCGHFYTQLRNVLNSRNFTELFNKCDEFLFKIRAPFIWLNVALWLLSLLYLIHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAGRVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Y0</accession>
    <name>A0A061D9Y0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769707.1">
        <property type="nucleotide sequence ID" value="XM_012914253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Y0"/>
    <dbReference type="STRING" id="5866.A0A061D9Y0"/>
    <dbReference type="GeneID" id="24566062"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400145"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400145"/>
    <dbReference type="OMA" id="FEPRFRM"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="313"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="597" mass="66494" checksum="52C1CA896428BBDE" modified="2014-09-03" version="1">MRNTGPPVRPPPAPSYNMLFAYFKQQGYNDELAASEARRMMIRPPPPAVDLKMPPPVPGPAVTYNRANLLSGVKLTPKNAWRIPLSTTPVATRKSASKNLIPITLKVSRGNDGAVAVVLSHKLQSPSAAATGATRRVPPQFSSDITVDVGKPTGASQPKKPYGPDVPTMDDINNWIQRLYAHHAMVLLCLESLMARQGACSKGFRTKISEFVERVVQRHRYASATARRLRLAGHFLRTVAAPNRKHRRRTAKPSSSVRGSSGRNGSRACQEGKGYVAACSESMLCQVYNFRPQKGRAVVGVCETLEKPYLRLTAEPNPAVVRPERVLRKAFRHVFDTFMRSFNYRYIEEQFRSIRQDVQVQHLSGPFVVKLYAANARIALVHGDLDQFNQCQTQLRHLHRRVGGFPQYQVEFDCYFLLYLSMQHMHMDLMLAGDALDSDFRSSAYFSYADAIRTFLSEGNFVEYFRVADTSGIDKDACIRAIYSEAFSTDNFTEGPAAGPVCPPGVDDLITAPPFYAKLLFKMFEPRFRMNALVAMASTAMSLSVDTIKETLRFGSEEECVAFIRENGGTMNQAGLVDCKGSLEGFLSSPLLRNKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA24</accession>
    <name>A0A061DA24_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769757.1">
        <property type="nucleotide sequence ID" value="XM_012914303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA24"/>
    <dbReference type="GeneID" id="24566112"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400630"/>
    <dbReference type="OMA" id="IHDESTE"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596133" evidence="2">
        <location>
            <begin position="19"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="954" mass="105087" checksum="E31B9B3DFE8B52DD" modified="2014-09-03" version="1">MMWKFFLVVVHYIVGANAEQNIKAKTKILDFMKYGIPDDENVFINRAVLSKNKALEIICPRRKAGYFYDILPNTRDKIPSGDIYVYATIDGVYQKVNINDVVRFESADNQPKLRQQFGMTRMLLNQGLSSGIVRYDVESFDVHCAPADNADGVHKGLGACLSSASLNEEERSRCKYSKKGSPMLGIVRVSLSSVPRAYTGCGSMSAPFLLDGWGKVSTGTSCVVDVMETPDVGFYCKGRIEPANCPFSLYYGNNDMLSRMPFKVDVSSSGYEGGTMLAMRYDRSSITSPFSGRCRCIDKATNTVTAVIEITSKERHVCDLSAKLTQHLSRPIAGDWCDVVLYPGSSLEILFPVTANELSSEVREALLGGDNVSGPISTFMPAKPDVEALTRTAGENTLVYGTVPLISVVDPKVVEVDSALLSDGVVYIQHKVSEAEPADRDPASFYFRCLHKGGSDHTSVTSTIKVTIAYGSPNESYAGDAAADALNNPARVSQYFTDMADTARLECNADEHMVPINCTVMAFNANRTALIPLPREVRTQIDTNGRNVRDFKVDESFTDAFSVHCSCINEYGVETSRTTLNQIPQKYTMKGRSPNMKSMIMVPRIMSYDVDGMLRHDKIVIPVSDVYNEKKVLRVSAGTLNGLLCTPPKGLTNVQRLPLPDDMRPFSSSIDNTLEGVRLNTDTVMLRQDEDVSKSYATWFPYNDSNEFVNLVKTGDEYTLTTADLNTVMISKGGFSIGYNVDHESDLIDRSDLTIRYPLGSVVISKDDNSEITLHYVCGSMSPPQPVEQESARGVEASRDAKSPVKEKRSMEIWEIAKVVVPTTDPYVQGCGIPSESDGLFRPDTVPLTDDSGKAIGCVVNLKTAKVAGFYCPLPYRTDPPDCQPVFRNNLAATIYKGILSDVNVSRSPNLLLFKKRKMSFAAMWKFAMGGGTYECHCITKTGMRISTVRIATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA32</accession>
    <name>A0A061DA32_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0312910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769574.1">
        <property type="nucleotide sequence ID" value="XM_012914120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA32"/>
    <dbReference type="GeneID" id="24565929"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312910"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="816"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="944" mass="106418" checksum="B8086FD160B27B04" modified="2014-09-03" version="1">MLLPSIGCLDWLPCDFGDPPELLSTNALAICNIDIDDFVPAPVICPRRVNDTEYVWHPQPTSAEVGKINTYVGGYGALQSVALSAVIRTESSNNLVWLESEESGVVLHFGISIDELVAITENRLIFICGPRDLVLSDTLQRELYRLDGFPHMQAMSWTPTTPLTEEIDKIGNGLGVVLVQRGRENLPLQGCGSRDSPLFAAGNEVTVDPVTGTRSCVVDPMSRLPIGFVCEGNVEPSDCMRLLLNEDGDVVIAPEPHAHWNFKYNRPWVVVQYFNNLALPPFSGECKCIDSETDQVKARIEIRPKTEYECDIASMIFRNRVRPISGPWCSVVLDPGSTLTIRLPETLVNTFYIEQNEEDNDEDIEEDVITVPFSQQPSVYEYETEFLPNDLIMLRQMKSIRRTDLNDEIPYHQALAGDAIELDVSQISRGEVKLKYRMDRPLALKSGTNSFFYHWSLISRNHNVLEKTRAIVNVSFAFTHYYNIVACDRKREPVFDREISKQHCVTKSVGNGIGETYQCTFNETSHILWAGINCAAEEELLPDNCGYAGYDLRSNNIMPLPSTVFKATAYPIPGFQLFDMWFQHGSFTYACICVDQRGYETSRLILEFSQEEHKEFTVLLRTGFNRLLPYQWLPWHNVKLLLDGPTSNRSIVMQHTSKHVIELQVGTTLSLHCGVGPELRGFGRIGNITTTWLPEQLDEFHYTVVHTSLGRTLTRKSHKDSVVPTSGGLEVRRKTTEMRPAYKQLMLKLPMGAIVISKDPFHKKYVPMRFVCGKTPTTSDLSTATGNPSTNSNITESSGKYTWHLVKIKLETTDPYMQGCGVTYETDELFKRDTPKIYDENEQEIGCMIDLQAAKEAAFYCPGPYLLDPPNCFNKVYVEDEVKHLGDVSQSLVASHSNHFVVIKFDSELVGRGETLRQTPPLGCRCVTTKGIVLSTIRIKNYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAE5</accession>
    <name>A0A061DAE5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768040.1">
        <property type="nucleotide sequence ID" value="XM_012912586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAE5"/>
    <dbReference type="GeneID" id="24564395"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210070"/>
    <dbReference type="OMA" id="YCVSLVF"/>
    <dbReference type="OrthoDB" id="368340at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9578" checksum="5030BB0FCB6F4E38" modified="2014-09-03" version="1">MSKAVYAKLWMATSQYHLRRTYGWMHVWKRLALWGAVYGAAGVWLYFPACRPENKKLLTLGYWTAPEVGYNKYPVVSEEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAH0</accession>
    <name>A0A061DAH0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0400400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769734.1">
        <property type="nucleotide sequence ID" value="XM_012914280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAH0"/>
    <dbReference type="STRING" id="5866.A0A061DAH0"/>
    <dbReference type="GeneID" id="24566089"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400400"/>
    <dbReference type="OMA" id="NYCKLMK"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="346" mass="38519" checksum="4A295A1121048EC8" modified="2014-09-03" version="1">MRYAQIVVGPAGSGKTTYCKALQDYLTACRRRCHIINLDPATEEYIRFEDVNSRKNNAADNDECSIFDTDIRDFVDIGAVIEEDELGPNAALVRSAEMLTDNIEWLAEQIEETYSDESYLLFDTPGQVELFVHLQYVKSISQLLNRLNINAVAVFLLDVSFMTDPTKLIAGSMAGLAAMANLHMPHLNVLTKCDLLYETDGSGDFTLKPFADITSSTFGLSSRDLAFQKKIFSKANPSKDEEEAYAEDLDDKEDELDSTVDYETLCGMINRGPDELLGALDSHLPQKFKGLNSAFVSLLEDFNLVSFIPLNINDEASLEQIVVATDASLQYGEDAEPRTNFDMYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK8</accession>
    <name>A0A061DAK8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769203.1">
        <property type="nucleotide sequence ID" value="XM_012913749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAK8"/>
    <dbReference type="GeneID" id="24565558"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309200"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="64" mass="7285" checksum="D7B033B464F159D3" modified="2014-09-03" version="1">MEVKEVPHVVRNYARTLPFVLLCSLGTSYFGLGKHIGLNGYRCHKHNVGTMLTDLRFPIPSVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK9</accession>
    <name>A0A061DAK9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769912.1">
        <property type="nucleotide sequence ID" value="XM_012914458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAK9"/>
    <dbReference type="STRING" id="5866.A0A061DAK9"/>
    <dbReference type="GeneID" id="24566267"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402160"/>
    <dbReference type="OMA" id="HINFFEK"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30345" checksum="AAE7CA0D8A972E2B" modified="2014-09-03" version="1">MGGHGGLNILPQKKWNVYRADRRYEVKYDEHRDIERRLDSRDQRKRQRLTDSLVELRRQSQAVRNIESDGNKPEGDSGLKEERRHSRRRNNRKPQPVPVNRSRSPSPASTAGSRGILQSEPSAEAAELVPLPEFDKKASGGHINLFEEAERDANERAKRQRENLIKSGSYVYNAASKGPRVVSVYTDGTPATLVPDFKPVCTPWYMRQRPGDVDGGVAVERPRGPRYCKTVSTFDDADGYYEERELKRSFATKLAKFQQNHALPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAQ6</accession>
    <name>A0A061DAQ6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0402540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769952.1">
        <property type="nucleotide sequence ID" value="XM_012914498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAQ6"/>
    <dbReference type="GeneID" id="24566307"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402540"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595624" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="827"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="957" mass="108712" checksum="33487B9114883C4D" modified="2014-09-03" version="1">MAKFMRVPLAICAISLQLLVFICAVEYDFMNGMSSLDTNPLVAFHINMDNIGIATLACPRQVNGTEYVWHPQPTADHGASLKTYVIEDGKFHSVPFSKVVVTEAPRPYVRKVSKESQTDLHIDLMDDDIYAITEERLVFICGPRDVVLSDALQGQLARLREIDEREVYLSDPTTSLVDEISKIGKGLGVVFLRRGLNHQLLQGCGSRPSKLFAPDNDVTVDHVTGTRSCVVNPMSTLRTGFVCKGRIEPNDCMKYLLYEDRVVAAPRPYLYRYFNTHKPWVVARYFNDVALPRFNGECRCIDPETGHVKARMEIRWKTEYVCDIASIIARNRFKPIRGPWCSVMLHPGATLTIKLPKQIVKSAAADSEFEEDGDIEEDASTAALSQMPSIHEYETEFKPDTSLTLRQLQTIHDIDLYDEILIHEAFTGDVLEVDVSQMERGEVKLKYRMDRPLALRKGYNSFLYHWTFISRNEYVLEKIRAVVNVSFAPSYRYKIVGCDRCRPGMFHSASDFDFLTIKEIGYGVGETSEWVLNVRSGEKQAGIRCGHNEELFPNNCESTLYDLSSNQITPFPTSVRNVTLYPVRGFQVFEMSFQNVPVSHACSCVDEHGYETSRLILRSNRREEYEYTVSREEANQRLLPYSLLPWSEVAFLYGDRTPMQSITLHNMPQRPIKLHSGTEFIMRCVMDHALYNGGNNAVGPPTWLPHFPIYYHYKVYTTAEGDRLIKKPHDERIAGTRGGFKVILSDYTDEYFDFRIKSDSGAILVSTDPDHSEYVPMTFVCGKELSESDFGQINDEEAAAAIPPPVAPLEEYTWNVIQIDVEMTDPYMQGCGVTYGSDKLFKPETPKLYDSIGRQRIGCTIYLQAAKEAAFYCPAPYVRDPPGCFDQVYVDAELKNLSDISQSLEVSHTNHFVTLKLNSELVGPYETLRQNPPLECRCVTIKGIVLSTIQIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAU2</accession>
    <name>A0A061DAU2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L37a, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0211810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768225.1">
        <property type="nucleotide sequence ID" value="XM_012912771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAU2"/>
    <dbReference type="STRING" id="5866.A0A061DAU2"/>
    <dbReference type="GeneID" id="24564580"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211810"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="94" mass="10522" checksum="DD79D8A06F993F4B" modified="2014-09-03" version="1">MSKRTKKVGVTGKYGVRYGASLRKQARKILLLQHTAYNCPFCGKDATRWKAVGIWECKRCKRRVAGGAWSLGTSTGATIKSTIERLYKQNVEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAU9</accession>
    <name>A0A061DAU9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768235.1">
        <property type="nucleotide sequence ID" value="XM_012912781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAU9"/>
    <dbReference type="GeneID" id="24564590"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211910"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="405" mass="44260" checksum="20CFFB08D2DC87E7" modified="2014-09-03" version="1">MVHNSLNDVPRNLKEGIDWLMALKGADGEKNLSALGAAIHNFLSYNLLKNPEEAKKLPSLENVKLISMGFMWKKQLRDLWPANEMLGKFIKTMSQKPTDLVNAIGSDPDEITANLTRFVDGCEKFLDGIKSTADYESAYSSEATWDASCSKLPEACAAVFVGIAPMLYVGLESMRDAGENQSIKWMPFIKKKNLGEVMNAMGYEDPVCREGMTGPYLTTALKNVNRDVLEIIHGLCGFDVLYASETPEPVKADKPVEPVSQSTEVEEPLVAEESLDVVKAERFAESVEVDQFAEIKELEQFAGFEEVDQFAEIEEVVQAAPLAEAEEVEEPVDVEPIAEPVEVEQFAGVEEPVIAEESVAQVETQPSAKPKKSGKTGKGKTGKKGKKGVSGKKGKKGKKAVVANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ1</accession>
    <name>A0A061DAZ1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0212310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768275.1">
        <property type="nucleotide sequence ID" value="XM_012912821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564630"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212310"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1813"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="844"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1875" mass="208661" checksum="E31366677B2EA62B" modified="2014-09-03" version="1">MTSLNHHNNLCLVPLHFLSSTSCHCPDHVPPRELDKKFDKILNLKNTLNNNPTNILNNLCSGLETFLGFNPSSKGYTGNGIVYSDLDRLCDGVMGFLSGVLSNIKEHLGQHKNEITQAIDTLNTNKHLGKKGFNDAIGSVVKGVRKYNGFLKISNDRVSKPVVELLSYFTEESSGKFCLGFNDIQVDKVSDDPKQTDPEVTKADNLVTQCLAKANEFNSKLDSSVPKNIKTQNAINDLNHKLRERVHSVRETVKYETDRLTTLSRKEKENYDAIVKMVKKLESVQSCFKSEITQRVTGLVNKLKEDVQKIKEKLEAIYKELERGVSALDTWAWEADGFVSDVMMKVEKILEEVVHPAERKKSINYAAEYIKGQAMSMQEAGDAAKNAAQENVRLALTQVKEMNDALKMDLYTVKQEIQKAIVNHVKEQIKTPYDELEGNVKQDLTVLKGKIEGELEAIVESSTTFSEQLTATEKAVEHAIGIVHSDIEKLQELTQIEQIVNDKNINVTAKLLKAIGGSEVIFQKVTEYFSNLNTKIMTPLKDAMKKIGEGWEIFVNGTNSYDVKNAVKKAFEELKKLQVVVNDANIAGNYEELKRSLTNVGLDISGVTGDLNSKFTIAAPTVRGFTASVDSLGKEEAKRILKELGEIAEAVSEHSSGVVTAVMTQVRQRVKEEIKVAAQTLNAKVQKIQQGVNGYNHNTNVQYSVVGNNENVKGLKALVNQFDTRIKNTLSMFQEKFESDFFKKKKPSSVNNDYEFGPNLMKTFKTAYDDLKDGALQENTFKSRIEGILSAEIGGDILPEGGGEVNKIGNIGQAKYANYTKQVDQDSLTHRDIKSMTGGLPTAIKQIETKVTEALASIENLKSDIVSHADDVKSKLAAMCEIVKKAAEGNSESAKGKLSELRSKIGRNTVKKPGDGVLMKIKNDLETLKKTQLHECISAATDFSNHAERLKTSTISSLQDIVDTQLNDCMAELTKQANTHYVTTMHYLLEQFADKVRGQLDKLPEAIEEDLATGFKGFMGAFQGQNGQAANYDNIEKLKDIVDRLSKNPTDYKANFEKLANKFQSFWQPLKTYLDTDLKREYAEEMKRKTPPVTIGEGDKHPYAEQLENVKDKLNILLTQLQDSGNFTHSVAHNLGILNNAHDNLVPTNFSSPCNTLVDALKSGVNALVSELIKTYLNAYDGASDGMVLVDARNDKVTDDGNKCAKVCLSLLSILYSEFKTLLKYCVARCKSDQININTELGKYFATQGYKVTEDGKKHWELQDSKGMTGLFICKRMFGKDEHHLYYIDKSKQNALDTLHDCLQTYYQVSHIATFSARKRPCNIFEMLCWVSGLPCNNVYQDMLDDAISELFVDPSKQPEDADGIPVTYISDEPLPAYPQNIAMDDTQRAVKRLCSRSHDILTTIAGTGDAYSMYAVDYSTNSLNFHYPSKGEDCLQMLLDILRRLLPSLKFLHTQCGLSSAYHGWSGCQYGRGVKHSNWQCGEHPANESTDCLPRSPLMSYLRDSLPGCLPHQLVSAGCKSECKTCPKSLPGAPCITPLGFRGFSGSTKTGKDICTVLTKFFDNSNINALFGLLPKPPSTLPEHFQFALTLSSMLDNANAASDVSLAFVTKTKALSIDLYKETSKLTGALQNAYRNQAGHTSSDHSKSTEADLSSLSKDSCNLPHERDIHCAPYLCSTSSDAYTYLAKKHADLYLSWAVYLPWTFYSYLKSLLDAFQQIDCGGSGCTKCSCKPGKHGVEYSCKCKALISCRGVMTTFYQYGFTFGDAKTLYGTNRKFCLSFSTQLSNLLKSQHFTKLFEECDNFIWTIREPFTYLVLALWSLSLFYLVCVMVGRLDVLHIKSHLRSPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB24</accession>
    <name>A0A061DB24_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768305.1">
        <property type="nucleotide sequence ID" value="XM_012912851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB24"/>
    <dbReference type="GeneID" id="24564660"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300240"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="6777" checksum="506D610174F7E3C9" modified="2014-09-03" version="1">MVDGTGYALLWLRGLRGEVVEGTGSGSGSVAVEGIGSGSGSVVVGECVARLRGLGAAVAEGSGKVREDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB67</accession>
    <name>A0A061DB67_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP-ase activating domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0402660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769964.1">
        <property type="nucleotide sequence ID" value="XM_012914510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB67"/>
    <dbReference type="STRING" id="5866.A0A061DB67"/>
    <dbReference type="GeneID" id="24566319"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402660"/>
    <dbReference type="OMA" id="MEIWIRN"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="33410" checksum="6660DD88A8164158" modified="2014-09-03" version="1">MFGSPIAGRICSIEGNNICADCGGRSPRWASVNLGVLLCINCSGVHRMLGVHVSQVKSLTLDNLKPEWIKVLTNVGNEIANSYYLHKLPSHAPRPHANTSAKDMEIWIRNKYERKIYAMDGVEEPYILLAKGYNPREIIAKGTLGPAARPQSQPATQEPANTAMGGSIKGFGGPEVPVCSSTSEDLFGNANAHGNAVFQDSAPQANWSGDFWPTSTPSKGRKASFDNDLIGTVPSSVSFESNKVAETKIEAAKDSISKLFDNPSQIGFKNSSYEQKTPNCVQGDLFDFNFSDLGNKLQSQQKQNDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBD1</accession>
    <name>A0A061DBD1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769463.1">
        <property type="nucleotide sequence ID" value="XM_012914009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBD1"/>
    <dbReference type="GeneID" id="24565818"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311800"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="84" mass="9440" checksum="0061396FA5FA9476" modified="2014-09-03" version="1">MQYALKNKLLRGVGELSSEGDKGTGNYQINVDTNCIYGKSKRGMVEYGYVLVKKVRKTKGPTYHHDKSLAYMTYVSGIKQCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBG6</accession>
    <name>A0A061DBG6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome subunit alpha type 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0403710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770069.1">
        <property type="nucleotide sequence ID" value="XM_012914615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBG6"/>
    <dbReference type="STRING" id="5866.A0A061DBG6"/>
    <dbReference type="GeneID" id="24566424"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403710"/>
    <dbReference type="OMA" id="NTQVYGK"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000063">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="30553" checksum="657CE141A2738CCB" modified="2014-09-03" version="1">MYRNQYDTDCITWSPQGRLFQVEYAMEAVKQGSCCVGIKSATHITSKIEIPQVLCAVRRKTSKHADYQDKIFRIADYIAVAMSGITSDAKMIVNFMRNECLNNRYLYGCDITASKLVSLVSRKSQANTQVASKRPFGVGLLVAGYDEKVGLRLYETCPSGNVVEYNAAAFGARCQSAKTYLERKIANFESCNVDSLLYHAVKAVKLTMPHDVEFTSDMVTACVLGQGMPFKLLTAEEIQPYIEKVGSRSVFDTAAVSLPIITLFQVVAGEPQDVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ8</accession>
    <name>A0A061DBJ8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0202820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767311.1">
        <property type="nucleotide sequence ID" value="XM_012911857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBJ8"/>
    <dbReference type="STRING" id="5866.A0A061DBJ8"/>
    <dbReference type="GeneID" id="24563666"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202820"/>
    <dbReference type="OMA" id="CGQIEYL"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01405">
        <property type="entry name" value="TETRPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="148" mass="16955" checksum="346FA195DE5CAEAB" modified="2014-09-03" version="1">MEVEGAIIKAAGIIVYTVDALAKEVKYLLLKASNKPFHWTPPKGRLDPGETFKDAAFRETWEESGLRKELIEVDESFKEVLRYKAHDRDKECVYYLGKLTDPDSKITLSHEHIDHAWVSASNINEYCDKESLCNMIAHAEEHIKGKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBK7</accession>
    <name>A0A061DBK7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770124.1">
        <property type="nucleotide sequence ID" value="XM_012914670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBK7"/>
    <dbReference type="GeneID" id="24566479"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404260"/>
    <dbReference type="OMA" id="IHVMEVK"/>
    <dbReference type="OrthoDB" id="365717at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596182" evidence="2">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="287" mass="32252" checksum="0D4AB391EEF0F47D" modified="2014-09-03" version="1">MRGLWPLVVSTAVAILNRGNAEKPDLQKLESEQKLLIHDLQRSRLASEQLKDKLDILQQSKNASSSTLNVSNVVVDKEQKPAEAHSGSANYTPPIIVLLPEEPSEREKWEYNLTLRCLGQRDFSPFEGIHNSKLLEMATIKGKTVAEIRLEIKHTEKELGQVESGSCRCISPQTRKELEGLQSALSSAKEGTYAERTQKLHISHNIKLVKHEIDVLETKLHRLQKRLKATVLFSSGTGKHGSSKQRDHDDADEEEASEDREEQDAEEDAGEEEEADEDDGHADDDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBL1</accession>
    <name>A0A061DBL1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0202920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767321.1">
        <property type="nucleotide sequence ID" value="XM_012911867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBL1"/>
    <dbReference type="STRING" id="5866.A0A061DBL1"/>
    <dbReference type="GeneID" id="24563676"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202920"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000037">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="40"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="141"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="362" mass="39436" checksum="463B3AC9CEEA5397" modified="2014-09-03" version="1">MSGPEERNLSEFYALGIEGSANKLGIAVVRGDGVLLSNIRKTYSPPDGEGFLPRHVARHHRENMAATLKESLSTAGIDISQISLICYTRGPGMGSALHVGAVAAKTVHLLTGAPIVPVNHCVGHVEMGRFLSGYKYPVVLYVSGGNTQVLSFDRQRQVYAVLGETLDIAAGNVLDRLARLLGLPNKPSPGLSIELAARVPGARMIPLPFVVKGMDCSLSGLLTRCEQLIERQKDMLSTGTCTKEDFKNFTRDLCFSVQEHMFAMLIEITERAMAFVESKELLVVGGVGCNLRLQQMASAMAEERGAKLYPMDERYCIDNGAMIAFTGISDYLYGRGENAVLAPQDVTVCQRYRTDQCQASWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU8</accession>
    <name>A0A061DBU8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769633.1">
        <property type="nucleotide sequence ID" value="XM_012914179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBU8"/>
    <dbReference type="GeneID" id="24565988"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313490"/>
    <dbReference type="OMA" id="EFKNCDH"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="43"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="201" mass="22863" checksum="472426213700E3F9" modified="2014-09-03" version="1">MSSRRALQWGPRPINAGRLRRVTRNPDVINRLVYWCFEHPEVRRTVLNACQGGKFTRLFGSLFNVETAHGYGLAHELSLPGPFTGFIPVDDGLQKLMHTLYESPPERIADFVRSHFTRDLWLHRDITGSPMQPWLPYNAPRAAPSSLLALSGRELAVENGGDVRIKTDYTTINGSKVLRWNMRCHNGVIHLVDRPVILEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC08</accession>
    <name>A0A061DC08_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768625.1">
        <property type="nucleotide sequence ID" value="XM_012913171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC08"/>
    <dbReference type="STRING" id="5866.A0A061DC08"/>
    <dbReference type="GeneID" id="24564980"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303430"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="17491" checksum="73A2299A361AB198" modified="2014-09-03" version="1">MASHQEYPAGQAPDCLVWEIVRDNHAHLHHAVHKRFSKERFNIMAVHTPRFSGRSSCDEGNSAFRPAPEERSRPRHLALRLQDLGLQGQGRPWRAPRFQHPRHQAQQEHGARRVPAQPRRPRQGRDRQGAGEQDGEAHPHQIRRQVGVNCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC34</accession>
    <name>A0A061DC34_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768675.1">
        <property type="nucleotide sequence ID" value="XM_012913221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC34"/>
    <dbReference type="STRING" id="5866.A0A061DC34"/>
    <dbReference type="GeneID" id="24565030"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303930"/>
    <dbReference type="OMA" id="YSEECQM"/>
    <dbReference type="OrthoDB" id="365118at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="94692" checksum="C58641D1CCA123FB" modified="2014-09-03" version="1">MRLQENLVWLKDSANAKKAVVTETDVSLANKLAALSNLKRCPGNASNDEITQYMMRKFGILKQMLPLISQCTPEFKQTYVMGNEFVRYVVAMTVKNQHLLTKEILTEALDFLVVLESPDVRDVLFMLLGALHKMPDTETLCLKHCNNLLLLLQNTGGRVDTNEIYDLVTSVIFKVIIAGIDIDALGAALSVLHIMREHYPEDKQLQELTTIYIGELKRHIYALEPAALLNVLQFMYRTAYADDALYTSAMEALLYNFDLMTSEEKSTLLLMLPFLKHMCLLLTPNIATNVYSEECQMLNAALRKEFEHKIEYMPFEEMITFCLAISLMFKQSGVVRKLLLKNIQKPMVAAVDGKTFLKLLACCNTLHINSSYVDVSRLLSKMARGKLAGGTGPELLQAFKSLAQISAKRHRKYLIPLVQDALEKNKSDVAAIIDCLHLYVTLNMQRINANVLESGFSLLFPHLNPRNQINVTQIQCGSAEVVTDKVAEEVLGHLSAGQCEGLGATGEGVMVNDCCDPSSVSTPAHHEGTLRTDNKMAVKKDTDLLYIAKSGSVAKDIPLRGLIKLLECLTKVELDISHVQPIASLIQTSILQKVKYNSTVSMVDLTAVLKQLTESRIVCAELADVILDRVYNCPDLLDDLECAATILQFIEFTNHGDYATKLSQPLFEFCLRKPTTTLMEVLDYQKYRRPDFYTAYMEMMQPAPYDVPDRLGGVVEHTPIMGTDVEALARDLRLPQATGGKSHHVLKQWIDKHDNGHEYVEFHKIDNLVVDFYYPGLRTAVQVIKRQDYYACHRGVHLKSKMWLFCDLLRMRGIRVIVVPETRLQAENVAESTHIQIKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC67</accession>
    <name>A0A061DC67_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769813.1">
        <property type="nucleotide sequence ID" value="XM_012914359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC67"/>
    <dbReference type="GeneID" id="24566168"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401190"/>
    <dbReference type="OMA" id="NNALEWH"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="242" mass="27339" checksum="4DCCCBCB50513888" modified="2014-09-03" version="1">MIPSVPHIDTNSFKNYIEIPNSGIRGLLSASTAKILTNSPIPFKEYVEGSQNAHHYPLSVLPRKLSAKLGGDVMVTTYDVHEKDYSLADGRRVMLSVIPTLKSQPSEVLLQKLQGKNTLLVVFSGDPPYADANNALEWHSAADFDVHKHLILNYACPVGMSHFYKRYVTTLASSLVNRCNFSCVMRKLSAEETIAFHQYRRSFTSVLLLDRYGYIRWHAVGKPTLEARYLLKEAYDQLRSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL2</accession>
    <name>A0A061DCL2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vesicle transport v-SNARE N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0403350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770033.1">
        <property type="nucleotide sequence ID" value="XM_012914579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCL2"/>
    <dbReference type="STRING" id="5866.A0A061DCL2"/>
    <dbReference type="GeneID" id="24566388"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403350"/>
    <dbReference type="OMA" id="ADEYLCC"/>
    <dbReference type="OrthoDB" id="359930at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="24975" checksum="11BEF23654B1CE17" modified="2014-09-03" version="1">MDDLFEEYHRHVKGILEKVSDQLRVCDQGAIGSSTTQRQNIEQLKKVISSADETVRQLELEARASDGDIATTRIEEIRRIKSVLKNASNRTKGLEIELERMQLLGSGRNKQPEGGHYNQLKENDRLIQKGYEYLQTSCAMAQETEMIGASAAGELYEQRNVLYNVQKEVQETKFSIKEADAYLTKLLKQGRLNAVVMRVVFGGILVAALIIAISRLLRTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL8</accession>
    <name>A0A061DCL8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0207990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767831.1">
        <property type="nucleotide sequence ID" value="XM_012912377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCL8"/>
    <dbReference type="STRING" id="5866.A0A061DCL8"/>
    <dbReference type="GeneID" id="24564186"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207990"/>
    <dbReference type="OMA" id="NRYFAVS"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="37099" checksum="56B581D6B849E912" modified="2014-09-03" version="1">MTRAVPHIVGNFHSLVYIRVPVDDETLVYARKAANLLRRLNCRAKLDDCIPARTQENSDSDDTDEEGANQGNAHTKKLPEHLHLSLCKPVYLKRQFIKPFTDRLEEALRNHHDINERRFYLLLDTNIAICANEEHNSYFAVLPVEAQCRKRSVLGTLMRSSNMQVVPLIDAVDSVVELFGYDRYYEQRQPHVSLANICQQNLKHVMQRLYAGHEDGDGDLYSSHHWRQAERFLNDAQAADDAQARDGGATENDATGTNGHSIDNRDVVASHDCEGTKEVRYTFYHGDLLTHVGDDGPANPEPLCVYVEDIHVQVGSQTTVIKLSKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM1</accession>
    <name>A0A061DCM1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0403550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770053.1">
        <property type="nucleotide sequence ID" value="XM_012914599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM1"/>
    <dbReference type="STRING" id="5866.A0A061DCM1"/>
    <dbReference type="GeneID" id="24566408"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403550"/>
    <dbReference type="OMA" id="NFSCFCL"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="331" mass="36463" checksum="CC39FCE49E377036" modified="2014-09-03" version="1">MSNVLLRALDASEKPMTQSALSWLRQTSTVATMIDGGYVLVDFYGEKGVRKSMDDECVVCPSLSALNSDLPPTYEFLVCGLFDGHGGRSCAAFAKEHLLKEVANQLVQHLRNSKDNGSKFSELLLKKSVNAACSRLDSRIANELPNCTDGCTALLVFVGRNRVFVMNLGDSSAYMCRRLQGAVHAIPLNEVHKAWSQKEKERVLHYGGTVEGGRINGVLEVSRSFGDLSLKRFGVKCTGSLRRAALDMNADEFILVGCDGFWGAYDPREACRNALTFIKEEEARAKADPRNPFVNLHKVCKDLVNHALNTKHAQDNISVLLLRFVCTAEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCW9</accession>
    <name>A0A061DCW9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769130.1">
        <property type="nucleotide sequence ID" value="XM_012913676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCW9"/>
    <dbReference type="GeneID" id="24565485"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308480"/>
    <dbReference type="OrthoDB" id="2194416at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="15105" checksum="50243E9331B109E4" modified="2014-09-03" version="1">MHHFRDTYAHISHIKMHLEGRYGMEFGVEDTTDKSLRDLRVAQNKWLYNRMHDPMLDIEASPLYLTCGILIPEEEAKAAEVQDRNLQWMASSKKCTRCNNGKNVDHLATKWPSIVELEANTDVIWVIGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCX4</accession>
    <name>A0A061DCX4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767981.1">
        <property type="nucleotide sequence ID" value="XM_012912527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCX4"/>
    <dbReference type="GeneID" id="24564336"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209480"/>
    <dbReference type="OMA" id="WEPNPIY"/>
    <dbReference type="OrthoDB" id="392873at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="316" mass="35443" checksum="3632954105C51F36" modified="2014-09-03" version="1">MSSSSRSSSDAASSSDEGAPWNATDDERQESDPASAEPPYFDVEELNEEEQNLLVFMCFCSYLDWQDRFLDAYKEVLVNRGVETRSTAPSESYALYTSLRETVLRQRGLLKGEGDSADDGLMSDDESVAEESSIFRTLARTYRLELYLKLIMIIFLLKLPSVCYVVVTALYALYIFIRIRFASVFEWPIFNGQLQTRIREVTGRIYRTTRRFVPFLNRTAPPPTATAANANATTNANATTNTAADTPPAARSNDDAVTPAPQPASAEPAPTEGRSTTTRRRAPGYITKVLYQLVAAYVLSLFPWWEPNPWYLQENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD56</accession>
    <name>A0A061DD56_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0211120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768151.1">
        <property type="nucleotide sequence ID" value="XM_012912697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD56"/>
    <dbReference type="STRING" id="5866.A0A061DD56"/>
    <dbReference type="GeneID" id="24564506"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211120"/>
    <dbReference type="OMA" id="SMVTEMV"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000013">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme ISCU, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="151" mass="16412" checksum="E3831C6AE327000E" modified="2014-09-03" version="1">MVSSTVYCTPKSLVRVCRRFYSPEVKDHFYKPRNVGSFDKNDPRVGTAVVGKAACGDVIKFQVKVEDGVIKDACFKTFGCGSAIASSSYVTELIKGKTCAEAAAIKNTDIAEVLSLPPVKVHCSLLAEDAVKMALKNYEEKNKLNTPKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD65</accession>
    <name>A0A061DD65_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin-tyrosine ligase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0310420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769325.1">
        <property type="nucleotide sequence ID" value="XM_012913871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD65"/>
    <dbReference type="GeneID" id="24565680"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310420"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF154">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="506"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="737" mass="83377" checksum="D6CD53A04FD16842" modified="2014-09-03" version="1">MVDMNYTDTASFKARMWPPHLYPAINHATTVRQRCSQTTKRSASIAPTRCKHPTNAAMRRKSFACSKDEQVLRRINDIIGFVDTMDTTKKDITSDDRSTCDSQTGISDQVPASNLVKLLSSRLHELSKLNQSRRTAKSRLANPVDNGIKATGHVAMSGVASNTALSHWGAGGSALAGGKCHDGNHRREYHGANMAWPYRAATLYKRPVINISSAKADAAILKEAAKRLRWDTCEVGAGGDIFWFSTCFTERMLKDQSKALFGITYKKVIVNRFANIQAATRKSLFACLTDIYVRYTEDDPCLYSLATCPKTYLFPKCNRKVLSEMRSGIPMILKPSTGSMGNGIKVVTCPERIPQTIARGDNYICQVYIARPMLLNGRKFDFRLYMVITNIGGGFHALLSTLGLARVCIHPYQLPDSNNCNDKFMHLTNYSINRHHARFQRSADVDDNAGHKRTMRSVLDTLSTTHGINSNEIWAKMVTLSEAAVSILYPTVQINSDPSDAYSFQIMGLDVLLDEDGKMWLLEINANPSLQYMYHENDTVKYDVVDQHVKVSLVEECLKLAHRLRCGSTNKEEMQAWIELRVRIPPEIGDVTALFAEYKSKYKEEDIQCDDWLRFCKDNGLVAAMQDSIQSEHGNKASNGKIDLQETKKIMKNIFLRTHTRRSLNGFPEFLSHMEAIATFIYKKMKYKDPEQLVAEVETEVQSADSQNRRRDHHNIRPAACLRKLVDHMQFYTDFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD98</accession>
    <name>A0A061DD98_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0212270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768271.1">
        <property type="nucleotide sequence ID" value="XM_012912817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD98"/>
    <dbReference type="GeneID" id="24564626"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212270"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="9711" checksum="245BA168E4AA73BE" modified="2014-09-03" version="1">MVHTLNFDASYSEVATTLTFTAVPPRLTPKRFDAFSPLTMSFSIRIVLNAVSPIIVYTKGFKFVIVYVFKILGASNALGKSQQIIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE7</accession>
    <name>A0A061DDE7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0312270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769510.1">
        <property type="nucleotide sequence ID" value="XM_012914056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDE7"/>
    <dbReference type="STRING" id="5866.A0A061DDE7"/>
    <dbReference type="GeneID" id="24565865"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312270"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="314" mass="35761" checksum="67454C429E5657D6" modified="2014-09-03" version="1">MVSGSIRSCDRAAMCVDNFSMFFGQPCSLEVEIDSDPGRPLVFVDPQQKTDKCPVFSDGEEISGTAVISLKPGKQFDHQGIKVELIGQSDTLYNKTGTYDFFTMSRDIEASGSVIESKSYRWKFPLVGIENETYWGVNIRMYYFVRITIVKPYGGNICKDAMFAVQNVGIPPQINNTIKMEVGIEDALHIEFEYNKSAYNMRDVILGKVYFLLVALSIKYMEVAIQRVETITLGRSVVNETQTVTTFEVMDGSPVKGECIPVRIYLTGLDLCPTYKNVQNKLTVKHYINLLIVDEDDRRYFKKQEIEFWRDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDG4</accession>
    <name>A0A061DDG4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal peptidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase complex catalytic subunit sec11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0301540</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768436.1">
        <property type="nucleotide sequence ID" value="XM_012912982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDG4"/>
    <dbReference type="STRING" id="5866.A0A061DDG4"/>
    <dbReference type="GeneID" id="24564791"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301540"/>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="16">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR96250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="183" mass="20623" checksum="8A40E7776FBAEC22" modified="2014-09-03" version="1">MDIIKREITTFKSEVRQFIRRPRENIEQLLATACVLFTALMLWKTANLYTGTDSPVVVVLSGSMEPAFYRGDILFLMKHDTVSAGDIVVFKVHGRDIPIVHRTLSLHANSNEINVLTKGDNNDVADRGLYSRGQKWLDGKHLVGTVLMRIPKFGIITIILNENRALKWSLISMLIYLVLSGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI1</accession>
    <name>A0A061DDI1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rhomboid family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0301890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768471.1">
        <property type="nucleotide sequence ID" value="XM_012913017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI1"/>
    <dbReference type="STRING" id="5866.A0A061DDI1"/>
    <dbReference type="GeneID" id="24564826"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301890"/>
    <dbReference type="OMA" id="KFWYLKG"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600297" evidence="8">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="242"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="404"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="477" mass="52449" checksum="013FE58967400FF1" modified="2014-09-03" version="1">MFLLVLAEILLLCSPLAESHRPTYAKGISGAHGGHGRTSAFLKAPRHLPVFRDGDGRGLGHTDLAFRPAKIELRVPSTQLGAGKCDWRLPKCDTTRDWGTDTTGRDHPPQQQSTSIGPTTSLAAISNTLPSVYDWINNQKDAIRSLKESFKQRFTSPGTYLARVCRESMASAERGCRIVSKELHTWYLKACNLGFKGIIAFSHDPIANIIRVVSFAYALDWWVAPNSLRMRCDMNPIDVFSKGQYYRLFTSLFMHNGVIHMLQNVKSLWAVGTEALALLGPRRLLAVYLASGIIANYVSYIYNFAYKNGLPADLAKMTQAVVRRVGQTGRSTSSLVEKVVDRIRNRYEGASLPVFMLSYANTTLFHLVDGAAGALLPFVKRARQETNDPEVENAVNAYIRRKIEKRRACGASSAIYGLMGAICACHLRFGGAAERKRVVEVATSALIQNLVPFAGGNVDHVSHLAGFLAGMGLTLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ9</accession>
    <name>A0A061DDJ9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0302140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768496.1">
        <property type="nucleotide sequence ID" value="XM_012913042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDJ9"/>
    <dbReference type="STRING" id="5866.A0A061DDJ9"/>
    <dbReference type="GeneID" id="24564851"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302140"/>
    <dbReference type="OMA" id="IHNDMEW"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="250" mass="28307" checksum="D8F4B6C80E84EFDB" modified="2014-09-03" version="1">MLRITRLFAHAIGQNKKVLSIDEALYLAKDAGFATKAEIQKLIVASPPFSPDKSPFLISNFFNEKRGCQTFDEDIEEAKDQSTQIDRIISSQQLPEISQIDHILAEKTNPGSTNFFWNQGERWKVRADGFGTCMRSTTHLIIQRGRGIVKVNGEEDLYKRWPIFYNRMDVLEPLYLAGCCGVYDVFIETRGGGITGQSRSARLALARALVSANPSVKYALEAALYEDTRQKMPKMPGRTGARSLRKWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDN0</accession>
    <name>A0A061DDN0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768586.1">
        <property type="nucleotide sequence ID" value="XM_012913132.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564941"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303040"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2189"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="972"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2251" mass="253983" checksum="D75BBE09296691A7" modified="2014-09-03" version="1">MAPHFKKLTDCPENLRESIDWLIQIRNGGDKTGLQNLAKALDKLINKAIEDAENSLKAEEEKLKCPIIYEGNLSYCQINEKSLKEAEKKLEELKEKNDSESLSKKTHLEDEIKLFTGYKQKCIEYTHPRYPDSKALKDVRAQLKGLQALSKTLNPFFNKLNKTTKNDGDSILHNLFDGLEKFLGYSSTSKCYDGNGIVYSDLDRLCDAVMYFILKCLECNKDLLTHYYPSITENIEALKNNIGNGLGVKGLGKAIQKIKEGLQGYERVLTSRSQKVISDLSNYASQMPARNAHLWSVQHKGLSQIIDRFNLYINNAKETMRSIRNNSEGFAGLDGALKNKLSAPFEKINEGINILQNSLQTDDFVKALNVVQRTFDVLPSKVERIISENVNGTISEHENAVNRYKQHVKNDIEKSRDTFLTERLKVAITDLNNSINCAQLNALNLGGLRNDVVKHVVEAIETRFKSVDEDVDDEDTLKELKTGTVAIQIENITENLNEEKALLEVTSKIKSVQVDIGEPDEIFNKAHQIGLQKLVMHAQTNLQEALKCAQENAKNMGGLKNGKVAGVIDNIQKKFNEVDNIKTIRELQELESNFMKGEIQKITEILNNENAAGVTSTLNSLQKNIVAPQKLFDDNYTTILAPLAKQSQKEMLATVENATECITTHGVLHKQKIKEALEKIENTLQEIETPAVGIEKLYQVVTGVEEQLNQLDSKIGSSLQATVKPAIQKLNDDFMTVKNLVKQRRPTTNAELIFLITATRTYAVEALHLAETYSVDASGSPNTDISGVASTIRHKNLELLDDAFSNKSITGLHTRINGHLSKLNKTNGSYKGSKPFASFEIDDLTTKIREAEKSLIRSLVGSAKPRIDHYFTTATNLTGQLDDHDTTGLKRTLGELKGSMDDPDKITDINEFSSLVKKVGTQFQKLRTQHSSPSNSTFKSLFHVILEIEKPAWKAIIQIESTVFQTAINIARAAVSAAVEKAKKDIKAAEDEYQIAVGKIRARIETAVERLQEQAAQDQFRQVTSGISPLFEEIAETVTSKSIYLEDMGERKKYFAALKALIDHTVTTLEATYQKAYQSAAKSYLSGAIGMIKTAVDEAEEKYVRAVETRILQIQSKLNGVREGAFKSAEKRGKLETAFNEDFVALELEVNKNSAFTDDFSKRRDCFIKVKEIITNTVKSLSTAYKEAYKSSAKTYLTKAIIEIESKVSDAEKKYTDASAIAVQAITSAINGLGVENFKVNEQRERLTDIFTEHFKNLQKAVESKSAFKQDFNSRTECFENLKSLMNRTIETLVKAANTFDACATMATEYLNKSFNDADTRIKALGSIIKMRVKKAFDQIISEVYEMYAAEKRAQLEALKTCITEQLRTISKILEEDRRMGVKGLLKTLSGDNPNSLDPRNRLQNVEDKTSVKLLAPLIMSYLDSILIYIWNDIETSTDSHFSDGHFYKSKIEEIKTALNEVFNHLIDTKDKIYNYDYVFVNLLEKLNNVLDDLSPQEFGAMAYPVLDALRKGMAGFTEQLNYAYINKYEGSKAIEWYVDGQKQKPSQDATRCAKIFLTLIPEWDKHLPYLKRECIRGWNKTQINTQKGNKLGLWFERRGYRVSTSDETQDGELRNNAGCQGTNINTCMATLIPKVNFGNLLYNLYQYYRVCQSKFSDQAKPPTTICQMLHWFCGLEYTPMYENVKSYLQEWFNDFKKEHEIEKALPATMPKRTGHEVFTDFNLGNLLGSYQNVTIRASEVLLTILGYGDADGRYACEFYTNPYNLYYPTDKSKCFDMLVDICLRLNHQLRFLYMQCHNGPRSSGWADCRYGKNIAGSAWNCNRLQCVENGCNQNCKWHNDCGVKSPLQSFLEDGLKGFLPHQFNSPSCKLDCSVKNHNGIPCKTPMGFADISITASWTKTGRDIKKVLDPFCGTLPDSLSLLCAYFLCLLRRPPQTLCDMFAFYENFFEHWKGHYDSVHKGHVKKHKHDAFYAAVASANFGVEYDGLDPTTMFGSSSHSSAATTHLEGDLFAIVNCKPNENPVHPCGSYLQPLSYEVRCVFTEKLAADYLSWIVYITETFYNLLNDLYNKCTKCCIQQQADCCGRICAKGCTVDSTAEPAESKKLTHKTHGELCNSILQCAGIHPTIFAAGFTFGSPWNLSGDNGVEKKRSCKDFCTALGMVVRENNVLYMLVHEKIPAFLWEIRYKFFYTLVALWAYSLLYLLYVIIGRLDTFHIRSHLRLPSSHKISAQSLLATARLNDLAKLAYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU5</accession>
    <name>A0A061DDU5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">-Phosphatidylinositol transfer protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769885.1">
        <property type="nucleotide sequence ID" value="XM_012914431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDU5"/>
    <dbReference type="STRING" id="5866.A0A061DDU5"/>
    <dbReference type="GeneID" id="24566240"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401910"/>
    <dbReference type="OMA" id="YIIVCGF"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="587"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="723" mass="82781" checksum="111B379D69736C4F" modified="2014-09-03" version="1">MKVIEFQIPLPLTLEMYERCCVYLVTKASMKEVESGGGFEISRNELCEQDGVLGRLMEKRFYFGKSLPSWLQSLLGRELTIVSEHSWSVFPYTMTSYSNKKLTFEFCFESITNEGLEPQENALNLNDKDLSRRKVIVLDITEFKKCKLYDSQFDVTVKESQHTDALPMKPGWWKQPGSVGVIAHKVLKVDIPYFGFLSSRVENYLVNYLQDKLMLYVCTAMCSIDEWYNADIKYLRMKEQECYDVLNQNFREQYGHIFRDSQELPAQDTPKASSSSSFEEKQREAKSPSMVETAVKPQERLLLVPLLLVLLPLLCLIVFRFRFLLLLMFMFQLQFQLVFQFLLLLPRLLVFMFLLLLLLVLQFLLLLHHRLVFMFQLPCRQNPLALCANKCPYHQAKQMMLRFHRNPLIPGDGAVGGAYVSRAVRVVTAKSFRSVTGEEEFWDCMEELEDANSTMASVPSRRPSLSTVYTSSSAVRAVSALKHEDEYVSSSTGPASSGSRKSGSMEEHGYRHVHEDRASQFRIEAEDVLPIPDDHSAIIEYKVPGSSIDNEESEPMDSERGDHSSSSLGDVDETVAPLAAAAERYTPSMFTGYLYKLGGTFFYQWNIRYIMICDGNMHYYDSRDDTRPKATISLMDARINWVGHYMGRPNVFSVTTRAKRTYYWSAEEESTVKRWILLLQVLSESSPEALMDDLATEYLYRVEKAESVGGCSPPSAGSYMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE39</accession>
    <name>A0A061DE39_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">BBBOND_0404470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770145.1">
        <property type="nucleotide sequence ID" value="XM_012914691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE39"/>
    <dbReference type="STRING" id="5866.A0A061DE39"/>
    <dbReference type="GeneID" id="24566500"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404470"/>
    <dbReference type="OMA" id="AACDQTT"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="94" mass="10382" checksum="A54E97A6F20EB165" modified="2014-09-03" version="1">MAPSLEQFIECQVCVVTVDGRVFVGSLKGFDQVTNLVLYNCSERVFRKGAAFEDLPLGIYLIRGDNIALVGEMDVEVDKTLEGLEAEPLKPVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA2</accession>
    <name>A0A061DEA2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770285.1">
        <property type="nucleotide sequence ID" value="XM_012914831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA2"/>
    <dbReference type="GeneID" id="24566640"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405830"/>
    <dbReference type="OMA" id="WITRIHK"/>
    <dbReference type="OrthoDB" id="365320at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="818" mass="91118" checksum="F351D6F26C33E8A7" modified="2014-09-03" version="1">MGARLSTRCGRSQVKDRKVSIFELLLQLSKVGVTKDSEDEVGRLFQQLFDIPIEDIPYETIEVYFQNFVLHNLLSANLSHGQICRYWECYAALLEYIVKRESVAADEYDADRSGSVSLQNDFEITIQTSTNTTTSLGSNTKNEVSILRASPFTRNGEGRDYEPNCSKDSEFETLAGKEETHNPVGGSPSAANGICNTYESLLRGKCDVVRCLTPFVISKIFIRCLVASVNAVELLFHMEYLPYYLEWSSQAIFKLNAQDVTDISVTSQRQNVVHGDDDAENLSGQDQPQPGLEKENSNPSVEATAEECNYIGTAVEEEDVDGTSSEVAPCPCPSTVTSSQIYEENSEIIRTLRLRMSTEKEPINVPVNVDGSLESINNAIMEEALNAWSDCTTHALRRGFCFIDHRMRIFSLTCVVELLKRAQGAAEFMALPFCSVAYGGSGRASHLQRLLVALHAYITTDITPSSTSHATFIKASQSMATDVLVILLSSIVMAPYVNTCIDKRRTAEISPMFTCIKNVPKTVRSVAPFYYIHVECVRSQLFVNVPSDLPPNAIEPVVDYFLKRDAPMIYASMDSLRDAIGSRGVEDMAWCLIRLLSTSPQNAWKRHLNVLRDNVTLLMLIMIGAGKEYVFLSKTEEMAERFKTFEYSTGTLSLTGSSHTDEFIEETEANISQPTAIPHKSLNNIHHSLLFSEQLPQGLMVAMAKALDNLSPSMTCSNELWLILIDMLSCDKTFALTFYLKPGSFIREVMSTIKKHSAMKKEAIRGKTSGHAHEKCPHHLVSRSPLIRTLVNILVHYIIHKKVLVSSNDPKSDSGKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEC7</accession>
    <name>A0A061DEC7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769236.1">
        <property type="nucleotide sequence ID" value="XM_012913782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEC7"/>
    <dbReference type="STRING" id="5866.A0A061DEC7"/>
    <dbReference type="GeneID" id="24565591"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309530"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="379" mass="41662" checksum="C6F4ABBBC7D2BB12" modified="2014-09-03" version="1">MVKSARRRQRKAAKAQEVDDDAPRIVIIRRGSLRPELKQLVRDLRVLVSPNCASRLNEGSHQKMKDFTEVSEALGLTHLLAVSETERGCYLKVANLPKGPTLTFAIDAMALVSDIAKSSSNPKSIGGACHFSPLVVLNGFSGAPGGRGRSSVDETATAMKTVATTLNGMFSPIDVSTVKMQNCKRVVLFDKDRKSDVIVMRHYLINLVDCNTSNAVQELIDKRSIKRLMQDKGASFKDVLRTATGGKLDVSNLNDDYVELNNVDHGDAILRHKYGLPGRSDLEEADDEANKLAVRLTEAGPRLNLRLIKVEAGVFSGGVSFHKFVSKTPEEIARLEALSAEKRRMEAEEAERKRRKAEGDDKGDAQEEESDEAEESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEC9</accession>
    <name>A0A061DEC9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0309630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769246.1">
        <property type="nucleotide sequence ID" value="XM_012913792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEC9"/>
    <dbReference type="GeneID" id="24565601"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309630"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61571" checksum="E6F5AD1A42A3DDB9" modified="2014-09-03" version="1">MVGGGDSELGGVGESSRNAPDGKDGDTKADRIKADYGTFGQVLYHVVSFTEGYEQQVLYLCMRIFESTMRFTKSQLTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSATSRFSSQKIISDEDDEQSGNSSTFTRIHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYLWISVGIAIVFAMHTDSVLTTPYGSMDKFINQISGAFKAVFTNWSAFLCIFTMLIAEAPMCTLPYIITYLEYLGVSDMKVGIAILVTTIGGAAGTAAGGIVIEKITGMHKKYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIEDKYQASASAIIQCISGISISVSFVEIFAYVSEKLHGYSPSTQAIDDMDAALKDNNTEALRKSTMYMIVIGSLLNIACYGALFATYKEDKEKVEKANVEVWVERKVRQEKREALKKTKKQEEAVEGSDDLSGYTEASERAKLEVEIPAPPPEVDRMEQVEQTQLQGDRGPEMTEEERKNYLKIAQPSWLEETSSRYSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEG3</accession>
    <name>A0A061DEG3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S14p/S29e, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0311330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769416.1">
        <property type="nucleotide sequence ID" value="XM_012913962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEG3"/>
    <dbReference type="STRING" id="5866.A0A061DEG3"/>
    <dbReference type="GeneID" id="24565771"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311330"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="65" mass="7562" checksum="44723EB194B23DD6" modified="2014-09-03" version="1">MTNLFNTHPKNYGPGSHQCRVCFNRHGLIRKYGLSICRQCFRERANLIGFFKVGVPFRVSIALQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET5</accession>
    <name>A0A061DET5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 2a, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0403280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770026.1">
        <property type="nucleotide sequence ID" value="XM_012914572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DET5"/>
    <dbReference type="STRING" id="5866.A0A061DET5"/>
    <dbReference type="GeneID" id="24566381"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403280"/>
    <dbReference type="OMA" id="YTDVPKQ"/>
    <dbReference type="OrthoDB" id="412083at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01166">
        <property type="entry name" value="CYCOXIDASEII"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="10">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="30002" checksum="BAED4E4F1D50A1F6" modified="2014-09-03" version="1">MAFMLTSLRGAVGFRSFVGQCYVNRSGGIGALYKSQQDLILPRRLISASRSRAGAVNPVSGHNAAPAGRSPETESSATQVKTEDADANYKKGKYPGPGAPRPVGQPDDLPCIEFGKPTGMYNFVRHQHGDPRGHLQSDGRFRPTHATDSFHWYDAYTDVPKQRFTIVNGETMIMGKETRPMEELFGVPQTNIPFHPRRRMNLWGNHKIVLGAEFCFFWIPTFIILGLAVPCYTMIYMMDEAVATSMTVKVVGHQWYWVYEVESPPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEU3</accession>
    <name>A0A061DEU3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770066.1">
        <property type="nucleotide sequence ID" value="XM_012914612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEU3"/>
    <dbReference type="GeneID" id="24566421"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403680"/>
    <dbReference type="OrthoDB" id="366618at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="271" mass="30828" checksum="3E34A86FE1F97B61" modified="2014-09-03" version="1">MQLVITTVGILRCINSTLESYFAHELCKQYLLTSGRKKSHLFCYSKCSNKMLKPQDNANDAKPQNNVNQNDNLRAMQRMVYHSLTDVPRNLKECLDWLIAVKGTSKFNTQALGYALYNFLVDKPVGTTYVPSVEKVKRLSREFMQKKEFKDLPAVGDLLRRFTERMNKTDFVDIKRFFALHESDYENIVKVNGVTPDSIAKDVDKIADGCEQFLNEIKTPGQYESAYSSEATWEASCSKRPEDCAAVLVGIAPMLYAGLHSLQLATLYECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYE8</accession>
    <name>A0A061CYE8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765872.1">
        <property type="nucleotide sequence ID" value="XM_012910418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYE8"/>
    <dbReference type="GeneID" id="24562227"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100150"/>
    <dbReference type="OrthoDB" id="10342244at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="104" mass="12213" checksum="F7DE66D22C86E295" modified="2014-09-03" version="1">MVAALKKETKRTKATKSAGSDVPEQGEKESQVPEGQYFWQNPSNRELLKKIRRDKTVNKSSVQHKREGESLSHDSNIYVIRTTKHKKISYDQFVREKGRRRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ70</accession>
    <name>A0A061CZ70_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766107.1">
        <property type="nucleotide sequence ID" value="XM_012910653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ70"/>
    <dbReference type="GeneID" id="24562462"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102500"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="8036" checksum="F533924ECF9196EA" modified="2014-09-03" version="1">MQRSNELTTGLSDNSVNSCSRKCRLKCKRAVRYRNYADGTLRCLASSFGGCDVDSNVLYFAESYYDIIYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZP6</accession>
    <name>A0A061CZP6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhomboid-like protease</fullName>
            <ecNumber evidence="11">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0104040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="11"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766282.1">
        <property type="nucleotide sequence ID" value="XM_012910828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZP6"/>
    <dbReference type="STRING" id="5866.A0A061CZP6"/>
    <dbReference type="GeneID" id="24562637"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104040"/>
    <dbReference type="OMA" id="KCTLGER"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017092">
        <property type="entry name" value="Pept_S54_Rhomboid-like_Rom4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037023">
        <property type="entry name" value="Rhomboid-like_ROM4_ROM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="13">
        <location>
            <begin position="217"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037023-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="563" mass="63425" checksum="950E463A3D4BF65D" modified="2014-09-03" version="1">MDQESENESAVPSGDHFVRVAPTAPPNTMPKEMRGKKKIRNPNCCVEKRAKTVIDRRAPINPLEKLGLMSMKTSNVQREIIKGSDPMLERNPLVGRLPFMLIINATLVLVFISELVFNKLSFNGRCISKVLYPTAEAGKDPIMPYAVELGYGACEYNLNTSAANRFFFGNDAADSGWPAERVNPELLLKGDAAIDAPNERVFQILGGSDANMARNYNEYFRLIWSMFMHSSWKHLLFNVFCQVQALWIIEPDWGFLRTLTLFIVSGVGGNLMAAVLDPCGTTVGSSGAMYGLYGAMIPYCIEYWNTIPRPVFLMFYNLVTLIVGFVIGLSSNVDNYCHMVGGCLFGMLWGFTTIKSVSSCDKCTLIERSLLSPLISWALPRSWKAKLRLTIVFKKDRGERRREAFNAHKMAVESGVSMHRIAQIKKKFERNGAPPCRMRLREWFIRLTSLLTMISLVVLASLFLVNPALYSKYKPPGQYKFGGWRTCDCCYVTNIHRLFKTTDHITESYRNSDLFWCFNDVENAKHYCGEDYADNGPSQNVFESTEDAALGILSTVRTAINSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZZ8</accession>
    <name>A0A061CZZ8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766179.1">
        <property type="nucleotide sequence ID" value="XM_012910725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZZ8"/>
    <dbReference type="STRING" id="5866.A0A061CZZ8"/>
    <dbReference type="GeneID" id="24562534"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103145"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103145"/>
    <dbReference type="OMA" id="CNSEFEN"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57389" checksum="8313C91FCC8C6015" modified="2014-09-03" version="1">MDSADIQKQVELRKRAIDVLSYSHNEYLGCRDDEAESLRSILDRCVKDDVGGSVFVFGLSGTGKTTTVHHAVDQFISSNSKVRKMTMSGNSYTSAWHFVEFVYDRIARYTPPQKRAIMSAPLGRKLLDYHQLYEILCASFKSAPAYTVCIMDEVDYMSTYINSSKAFGRLNWMLQAIISASHAPGSRVFFIAISNNLELGTLITEQQCHVIRFKPYQDKQIIAIIKGKLAKLDGPYTSVINDTAIMLLARRVANTSGDIRACLDTFTRAISNSLSNLQEEIDRLTASSLTDYATSSENSTPERSLECDSTPKRCYGDMRSDSIELGSYQVGHKDVGSLTPTLSLSKTSLIEMKVKPLPLMQLLALLSVCKSSLDEEDPVLSFRSIKLRRSFVAYLTAAQRSLIHLADMLGMDKLDVEDFCTSKFKDAIDIFIELGILAKADVTATTDADDVPRDELVSLCMDASSLAKIVLPISPAFVGLDLEFPVDEIATSRYSRITKSFNIRVGPKRTRRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D077</accession>
    <name>A0A061D077_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766259.1">
        <property type="nucleotide sequence ID" value="XM_012910805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D077"/>
    <dbReference type="STRING" id="5866.A0A061D077"/>
    <dbReference type="GeneID" id="24562614"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103860"/>
    <dbReference type="OMA" id="MNSSKVC"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="28345" checksum="3E8EED54084864DA" modified="2014-09-03" version="1">MLRRFTRLIRAVERDQNFVQLQYSLLQEFEADPEHGGPAFRKVVEGAISALSTIKSPDAPAKLNAECVLLLEEVATYCRTAYPWPLVKLLLLVVWSHAFDELYEMEQAFTGTIYSKQEYYEERRAALELLFNFRKPPMTLQRLAEIPLRQTYMTVSKLVHAYRKVMLVRPLTDKEVGVQFSLTSEPSEEADMEALKPVEAALSSWFEVIKDPRGYQWHDDYWLGFWETKPEEEPPGPVKRPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0P5</accession>
    <name>A0A061D0P5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765898.1">
        <property type="nucleotide sequence ID" value="XM_012910444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0P5"/>
    <dbReference type="GeneID" id="24562253"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100410"/>
    <dbReference type="OMA" id="ILWCAWK"/>
    <dbReference type="OrthoDB" id="374157at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="24867" checksum="154773DF5A34809F" modified="2014-09-03" version="1">MEILTTQSDLKPQVLGDIYLGYFVPSVLCGRSDAFRRDITSFISEWISGALVSDLGSFLEIHPDFGLYSIGDLFRERHLSKLLVVSPKESVSDVWEILWGIWADVLKSISSDRYDAVSLLYGVACIYVMFYLYHCQTGPEILPIPLAIGESTLLVAYNAADTISICLDVCTVSLSRFRICTVSDVFDLLFRRHCIRVCLHDGLQYIPQDRVGRPLGCSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0T8</accession>
    <name>A0A061D0T8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766607.1">
        <property type="nucleotide sequence ID" value="XM_012911153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0T8"/>
    <dbReference type="STRING" id="5866.A0A061D0T8"/>
    <dbReference type="GeneID" id="24562962"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107300"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="263" mass="27570" checksum="F54CA71D9C1D1DCE" modified="2014-09-03" version="1">MADSSGGDQPTHRATTISISEGEEGNEGIYGTYEGSTKIEHKGANVGKMVSQAAVTSDILAPEEDGADDTPWSDDYGVGDTLWSEDAFTRGIRASEEAARRGIRASEEAARRGIRASQAAVTSDILASQEAVGRRILLQQEAVISDILASHAAIRGVGKRVSRAAVISDILASHAAIRGVGKRVSRAAVISDILASQEAATRDILASQEAAIRDILASQEAATRDILASQEAAIRDILALQEAVTRGVLASKEAVGRRILASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0V7</accession>
    <name>A0A061D0V7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0107390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766627.1">
        <property type="nucleotide sequence ID" value="XM_012911173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0V7"/>
    <dbReference type="STRING" id="5866.A0A061D0V7"/>
    <dbReference type="GeneID" id="24562982"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107390"/>
    <dbReference type="OMA" id="IIHDISW"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="8">
        <location>
            <begin position="251"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="538" mass="58768" checksum="934BAA6B24119BE4" modified="2014-09-03" version="1">MDAVSEAVASLTVRDPARSGRDWYIIAHSKKAQLYRFSPRGESSSGTRLVWEENDITHCYPSHSGAEVCIGRAGSSTLEIVETFTRSVRTSIALPADCTLSGALFSPKDTYLVVHTAWAEHNPNNLVIYLLDGSEARPVYSIPYTKSYCVKRYPIWTPCESFCVLRVGSELVVWKDGDFNAEGSVGKICLPGGAEAPQAFPTNSIISVSPMSKKGTCFIALFLPNQQKFADGVVKIFSSADLQTPVFEQLFSSAEEGEFFWNRLGTAAILRTFTNHVKGLQSYYGGNGLFLIHPMKRYYKTMMEPSKGLAHDVSWSQSGNDVIIVKGNMPSELDMYDGNNGNKSLTFGRSNRNTIRRDPFDRLMLVAGFGNSSGDIDIWDLKKRCKIAQSKSNCAVFCEFSPDGRYFVTATTVPRMKVDNCFKIFSYGGKLVHKVDLDGLALVSLCAPGATFSEREPSPGACSLQQTVTKSLYRPPGSRGDGSAAVHMRVDTQTLVATPVTRKDSVVLKGPPGADLTLLNAAAKVSRKKKAQKGAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1M6</accession>
    <name>A0A061D1M6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766882.1">
        <property type="nucleotide sequence ID" value="XM_012911428.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D1M6"/>
    <dbReference type="GeneID" id="24563237"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109940"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1624"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1627"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1644" mass="183862" checksum="3E944925DFDE2A76" modified="2014-09-03" version="1">MVAKSSVPEFKTLKECLQFLEWLKGRKWADLRSQLSGRLKRLLDKKYDGVNQNQIATALSQFLDLVSHFHKKLCQTAGQSIIKRITPKDALEALLQCIPKLLSVIYFLQYHVDKRFARIGGGDWEGDQVGKIAWFATYGPDVVKRMKANVGPIDKYLIETSGSKYGVIPGGFDPSDLKQLGRGGYSEGRLMTDDLVNIFDKGRNPNNLFRDVFVTSAVSKNSSVDKSNVANALRLVEDFCGIFKTSKNADDFKSHLESRGNCINWDDLKLHCETLKNTFSKLFTNNRFSFTGYGRTYEFLDKSMDKKMAKWLKNNLNAMRNQLGGVGRRLDVKTFVDTYLIPYGFTFNGYNVGKGKDTYQALKKDWDAVIGELKKDNGGLQKLKQLLDGTLCPKQKPQERDADDAKAVNDEGDDDDVEEDEDEIWGEDVVYEDTGLDTEDAAPITPKSEPPPAKVPESVKKSEGGQNQGKKAEGNSDQDNGQSATKSPVSSAAEALQTQPSSVTSQDLQSSGDPVSSSGQDPNVQGSASGPAQSSDQVYQTGQISNGASSAGSGADSGGGGAGGGADHSKMCRNGKVPIYLGFDSGGTKYCPGDGNTWDLFARKKMHDDWDKQKRESNLKIEQRKKQKEEKIQKQKEARELKTEYERQLQLQRPDLLPGIDVVYKPRELSDISEAAYDAAVQNQMKNATPTVPFQITLPPKRDANSYYTLDVFDVGKSPTHNMIKPDEIGLDGSIASDFNQLASDVGGDAVGSDEAVVDSSQLKVLLNGTAVKNGSDTEQQIQKDLIHLVNARHINSLRMKAQRDNDERTRRQKEAVERYKKDTEETWKQYEEKRILRQLGDYGRRQEDRRWRAAKQLEETLNDTAEDLWKFQQQKYVEEIESNVKDPDAKKRVQQKKEIQQNKQSGQQNISSDPPPSTDSTLPSQPSRPAPGLTPQPTGGRNSNGRGYYELRGRDRGQGDYIILGGKAIEDQSYEQREKERRQKAAEERKKLWDLETKLEKDRLREAMQRGLLDDVMEEVVDKDEMIVDIKGVVDIDGEGTDVSGGGYPALFTIEQRPLVNAEDESYSIDGQVVGVDESQLVFPVDGEEVKEKIGDEEGGLDDDKAVVIDGTMVSDADHAIFRHDGQIVVNIRGNEVTEKRDKQKEEERRMQLLYRNHHDHAKSLNGQPIPDPTDLILRQQEVTNMRRAYKEEEKRQRMKDQELKKMLDAAEKDINIPIQMPRNTFVVPLVELNGDAPAFVNEVEGIILANSSKSDANVPISQKIDPPVPQSMSSGSHVPDAELPSSPIPRDTFLTEPQPTREFQIELPTRTVREVYPQIGLSIEVPPHEDRIFNDVDLDDPYANTADILKDELKPPEDKGFSGLPNTNFNLDFAPERIGLDGNEDPGMPRDSPRKADERVIDPFSTNECLNPWSVDTSSTDIITPPTSPPPASDHLPPPRTVREMLYWFVGLNQYGLIGFITEHVNGLLKGYNTDALEVTGDPGQLTASHVTAKLTEACLYSATVIYKVRHNNDFKAFSTFDFKSVYSKLRYSTDPACLLCQLRDYVYACHHQLQFLKSQCNRNKLSGGWKNCGYGSDIKTPSRLQAFLTDDWDSTFKTHFFDPCNLCIKSRVRMGFKKDDLPETSETGNTLSSILTPSCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1S4</accession>
    <name>A0A061D1S4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766922.1">
        <property type="nucleotide sequence ID" value="XM_012911468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1S4"/>
    <dbReference type="GeneID" id="24563277"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110340"/>
    <dbReference type="OrthoDB" id="10471021at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="231" mass="25990" checksum="B34BF45E29651C0D" modified="2014-09-03" version="1">MEENLASAAAQVSPFEAAARTGEAISSDESEGTSSSYDSDQFITDTEMPDHKDPEHEQEPELEQEPEQQPVDDDAPQETVSQPRVHHIVPRHVPEPEPSAQQEPEDAPEERSDDSDSDRYVRSSDDDSDYHYGRSPYSSGRRGMSSSDYEEFDIRSRPKGRSRGLSARCHYYNDPEEYKVPESAGGAPGSYDVVAKRKPLIIRAKNCVQNLARKQYDAVAKLTRYCKKQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1V0</accession>
    <name>A0A061D1V0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766942.1">
        <property type="nucleotide sequence ID" value="XM_012911488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1V0"/>
    <dbReference type="GeneID" id="24563297"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110540"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="6793" checksum="215595E15232B8A6" modified="2014-09-03" version="1">MWGMFPETFYLMMTKLRAAFPISSKRPSSPLNNLVGDGIPEEVNIDRYPAFRPRAYAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D242</accession>
    <name>A0A061D242_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0104960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766373.1">
        <property type="nucleotide sequence ID" value="XM_012910919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D242"/>
    <dbReference type="STRING" id="5866.A0A061D242"/>
    <dbReference type="GeneID" id="24562728"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104960"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="314"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="564" mass="62332" checksum="0656BC67205DFF51" modified="2014-09-03" version="1">MKYVVVIGGTMSGVGKGTVMSSLGVLLRSYNISCTAIKIDPYLNLDAGTMSPQEHGEVYVLEDGGEGDLDLGNYERFLNLRLSKNHSITTGKIFTHVFEKERRGCYLGKTVQMVPHVVDEIIDWISRVSEEPVDRMGWRKPEVCLLEIGGTVGDIESEIFMEAIRQLRLRFGSNNTCLLLLSYMPVVGNSNEQKSKPTQHSAKNLLARGLQPDMIFGRCVTELTAAIKEKIAFFTQVKPDNVISVHNSSDVYNVPLILESQNVAQKIIKLLEITPKTDLPLPKLYSLESWRSLINTSTTKVTIALVGKYNSANDAYLSVMNALKHSAMDAGYSLELLFLEAEKLEAQPSQVKELLQGATGVVVPGGFGERGTNGKMLAIRYCRENGVPFLGICLGLQLAVLDIAREFAPNAVHGEMAEAPLEDQAIIAMPEFLGDGSKGGSMRLGVREAHVLPGSLAYKLYDHQTVICERYRHRYEVNPDFVDRITNMGFVFSGTDPSGRRRVMLEFPSHPFFFATQFHPEFQSTPYKPSPPFLALVLAAKGQLSSRLDANGGKLRPGSKYEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D249</accession>
    <name>A0A061D249_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell division cycle 5-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0111140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767002.1">
        <property type="nucleotide sequence ID" value="XM_012911548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D249"/>
    <dbReference type="STRING" id="5866.A0A061D249"/>
    <dbReference type="GeneID" id="24563357"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111140"/>
    <dbReference type="OMA" id="NNWSRVS"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="742" mass="84465" checksum="DC51DEC66F26BDE9" modified="2014-09-03" version="1">MRIQLKGGVWKNSEDEVLKAAVMKYGLNNWSRVSSLLVRKSAKQCKARWYEWLNPFVKKTEWSRDEEEKLLHLAKLFPTQWRTIGPMIGRTAHQCLEHYERLLDKAQGRDMDDELDPRRLMPGEIDPAPETKPSRADAVDMDDDEKEMLAEARARLANTRGKKAKRKAREKQIEQTRRLASLQKRRELKNAGVNVGALRLHNSIMDYVKEVPFETQPPKGFYEPETGHEIDQSLRSIQQLEGKRRDEEQRRMRNDDTRKLKRLQQENIDEALAVFEKYDTTTATRAPLVMPTPTMTDDEIVQIVKMGADVQMFEENVATSTVARTPMTSSIMEEARIAAAANRLQTPLLGETNVAATPGTRQKDEFPVPSTPNPFKKLIAKTPMSIFTGKFGSAANSKYSETPLSVYSGGIGDNDDDDDPIGARARMDMAKLQVKASISNLPEPESQVEISLTGPPQAYIPQEEKRVPDQGERELIAARMRDEEEERNVTSAIKRAVERPLVYSTIVFVNDMVTHKEDHEYMTTSGMIQKEVIWLLQWDSLHYPQPGGRPCLEPVPELDVIPLKYMKAAERELKVETARLRSILGAPNEPISTEAERKIFRTFGYSGAKKRYVPQEKMQLSQRAASRERQCTHTARHLDALVKRNRALENKCAIATGGYVHRQTLLLKNIGGSTRLILSIVVGELHHRTIELENDLQAFQAMKIREASWAEARIAFQLAQLQRERDLNARLQRLYGELAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2B7</accession>
    <name>A0A061D2B7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767087.1">
        <property type="nucleotide sequence ID" value="XM_012911633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2B7"/>
    <dbReference type="STRING" id="5866.A0A061D2B7"/>
    <dbReference type="GeneID" id="24563442"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200580"/>
    <dbReference type="OMA" id="YWKILWE"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06462">
        <property type="entry name" value="Peptidase_S24_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="96243" checksum="FEDB23081D33792C" modified="2014-09-03" version="1">MSDHVQWFRFQNLQDDFIKYYRASDKHRIDEIRLSRLSILYGAATLNRRIEHIFKDEETKGMVICAHLKHSKVHDFYIIAACLIYGYTLLHTNWHADNEYTLLYKLRSTNCRLVIVDDEIETESMIPDVKYLRMSDVYAESIYKKSLTLRNYLSLVESSSKDGSGHRMQEMLSDQSKHVGNADPNAVMMITFSNSGISGIPRARRVTYGEMAGHFKALEAMGAWRPSDVLVVFMTNPTYDFFTNIVLYYCMSRGNVHVHFLQRYMSTYWKILWESNEHAKNVFAQLGKNYKILSFLFPRQLEALLTLDEVAQECKLFDAGNAVIGSPLLPRPSISLEQAGTDDFQDLPKVAFSKQHTAVSEAAEEPPVTSPKSATPSDPGHPLVSYGSGAMALARSSISKVSKYIFGKRMPSKSDPESREGGAEGASGADEDAGEGPRVAKPNSTDDCERPNSGRGNGKPRHISLYIPKLHLKFSELRNVLCDKNVLFLLTGTHANYDLCRLFACLTGGKKPIMKYGCSEISPTLTLIPPALEQQRLMELYHIGLNNKFRDKHVIGQYIGTAVDADRGLSVVRSVDSVDLNFMIPCVPYEPGYFVCREDDYTKLLLPRELHGSIMEDGTYLGLGDVGFYVDMFGYRHFYWSHKVDHSIPRGVAYPYFDMLALNQVMQQAICARYDLTEPVVRVETMWMPQPRGGSKIVCAVELITALRSEIAEDITSTFLDMCKSAGVFTSCPVPDEIRVVSIPWAYKGSVNYPVLRVRTDSMSPVLFALDGSRDLAVVIRATRFYRNDVVLYQHPNDGTELFGRLVEINASEAPSHKKRRVPCGHCWVENDNPRSDEPDSNEFGAVSVSCTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2N5</accession>
    <name>A0A061D2N5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0201980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767227.1">
        <property type="nucleotide sequence ID" value="XM_012911773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2N5"/>
    <dbReference type="STRING" id="5866.A0A061D2N5"/>
    <dbReference type="GeneID" id="24563582"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201980"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="251"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1079" mass="123608" checksum="FCBCB49EDC81BA7F" modified="2014-09-03" version="1">MNIISTGIASKKRVLLSRQHCDVKKGDLETGLSNFNRLLEKQKGDHTFVETEKCRFVYQPVDEYYVFVMTSLDSNIVRDIGVVKTLAEILQVVVQPKINEEAIQENLFELIFYMDELISNNKPEDLTLDQIKEYILMDSQEEKKHNMIQTTKEKEEKERRKQIAAKLEKRKQLDHNFMDSITEMPAFTAQPVDEYKSAAPMSETVTTPSGMRLSIQRPTTGMSPLGLNAMRHSPAPRSARDEESINILDAEAPAVIQIIESCSGNIHLEGDIDVLNIQGELVMTAFEDSARSAALEVSGNSEIKMRYHPSLDKQMASKNIIEQQSAQQTYNIGHSTALVKWRHKTSEEQYFPISLSCWPNTNAGETTVTVEMQNNSGSVLEALNFEIMDSRYNQIVVHTNELGGVERKPDAVTWVGKLEFTTKGDLNSILPFTLVAKASTSITHFKRCRTRGEDTDFVLGYNWERGHLMTCFSILIVFISVIPYCTGLRLRKCYIERPHLPGRNVEIRWKDRQGTNKPHKEYYYVCQDGEVRIPQVARKRAFTCNLLKAATAKAGYADPADILNRLEAIAEHQDFETVKSLFLDIFRWFAFKKIEFINHPHFTSIRKRFLETHFFFGRVYSRVLKSHFKFSRCYPDLSHLSLANRYVRWMNGGIPLEEQCITFLINKSCVRAHPLLIDRIAALVNLHDSVDALNAIFTDVRGNSNDLILSTRIANRHPVNSEAALWLHRWLDAAQDARTTRQLQTITKLQIYDSDDLEGDYVQSGDRTGHAPDAPVSCVPAAFEQIYKLFQRLDCLQGNKKDEHKTPMLNGNATLSRDELFSINMLCKLKQFEAQRDVGDLLHGLFSMIRYLNTKVNEGPSMHERSDFILAFKHHVCVPYLRCVMRASTYALSSLLRMKGVLDLLESGKKRHRYAPYCSESTLRSFMYYGMNRFCSMFNYTGTPRNKANDIFGILTKDSYYYLYRDSDDKIVASNNAPAMDLWNIGKRSHLSGPLQCQLVIRSYKVCIEDDIQQMIEKAKANLSAKIGVELEFDNIVNLHFPRYVNVTPMRAFDPTLLQERNSGLIEHPIHRFISILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2T0</accession>
    <name>A0A061D2T0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767099.1">
        <property type="nucleotide sequence ID" value="XM_012911645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2T0"/>
    <dbReference type="GeneID" id="24563454"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200700"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599977" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="81" mass="8741" checksum="159FFC55DAF21470" modified="2014-09-03" version="1">MCLAILGTTGTWLMLKLMGAQLPWLRLRGLGAAVVVLQLDALEIDVFDVSSSPISVRVDICNAILKDVKIVKPARVIVIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2U3</accession>
    <name>A0A061D2U3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766583.1">
        <property type="nucleotide sequence ID" value="XM_012911129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2U3"/>
    <dbReference type="GeneID" id="24562938"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107060"/>
    <dbReference type="OrthoDB" id="10452169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="171" mass="19198" checksum="62D29402B6EC8B25" modified="2014-09-03" version="1">MKTPTRKNLFGSSMLPDDLTHATDSYNVSLASRSSNPFYRATILDDDTLAQSSSARNSYDVLNSPSWRKKRSFQREIPTQSSVNSNKRSKMHHCTPVMNGALNEGISLPSGASVWRQHSYLLAKLSEHQQRADKVGVDIGLTYVQTLVDISLLLRDVDKCNMQLKEAFLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Y1</accession>
    <name>A0A061D2Y1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polynucleotide 5'-hydroxyl-kinase NOL9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0201300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767159.1">
        <property type="nucleotide sequence ID" value="XM_012911705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Y1"/>
    <dbReference type="STRING" id="5866.A0A061D2Y1"/>
    <dbReference type="GeneID" id="24563514"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201300"/>
    <dbReference type="OMA" id="NTFGWIS"/>
    <dbReference type="OrthoDB" id="371733at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="7">
        <location>
            <begin position="252"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="737" mass="81706" checksum="6104365408F70B62" modified="2014-09-03" version="1">MRHGLRFVSAAEARRRRVTYRTNYDTLKGRIQLTAPDSDTADAVYAEIIALEPGECLALRSAFHFRVLRGAVEFNGHVYTPRRNAYTKAILPTWSPPERMLALCKSADVDHGEADAAAADQPAHCRTCTGILAEHLLGGTCCAVRARLQEDGALAERHFNIAAADRRGAHSQPDPDCGALEYYTEQNPNLAGDTTVVALVPHTSAFGTVDFRRLLAPPRPPKIVVPGLLEAARELLLVCVRGERAPVLMLHGDKSAGKSTAVVYIVNYLLNHLDTVALLDTDVGQPIFAPPGTISLKFVTETINAPPHSLLAGQRPDAVYLLGDVKVTRPEMLLRHVHRCFEIYTTAVEDDRSVPLIVNTFGWISGMGSKILEGIAGITKTSVMLKLNSKHPNSASLYPVSTHGELEQAIRSSLDVESGPAENTENAQNQAVTMYKKVVEECGATLPWDETGSVVVETLSHSVAKSVAIEMVEQFRANYREYPYCGLSAWQHLRDSRGETKADPTPNDLRWLRACAMINPTFGDAMHFPQLHQEEFFGAVKTTAFRRYVRYPALFRSPKQIRIMAERYSFVVQINTPLEKMEEVCPAIAGSIVALCRGRCDRVFSNEIGGDWEFITYVYVHYLNAEDMTMLASHSEIDTPGQIHRANIAVLCQTVGLDVIPTRLCPMAKFRSIEGGVERLDVLWKPRELSTSQFVPFRRNSLLHMVNTQGAGNSAANSRKNIKRHRQEPRMDKFGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D307</accession>
    <name>A0A061D307_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0107800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766668.1">
        <property type="nucleotide sequence ID" value="XM_012911214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D307"/>
    <dbReference type="STRING" id="5866.A0A061D307"/>
    <dbReference type="GeneID" id="24563023"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107800"/>
    <dbReference type="OMA" id="RIVHHSG"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="104" mass="11912" checksum="3F773CA923FF2B64" modified="2014-09-03" version="1">MAVKEKKSKEAVMRAAMASRGKRKKWVKVKTKDKVNNAVFFEKATVDRLMTEIPKAKLITISTIVDKLKVNGSLARQALAHLEEQNLIKPVCDQHHQQRLYTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D353</accession>
    <name>A0A061D353_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767372.1">
        <property type="nucleotide sequence ID" value="XM_012911918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D353"/>
    <dbReference type="STRING" id="5866.A0A061D353"/>
    <dbReference type="GeneID" id="24563727"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203430"/>
    <dbReference type="OMA" id="CASYNIF"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF37">
        <property type="entry name" value="TARGET OF EGR1 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="364" mass="40759" checksum="27E44D476B3FE48E" modified="2014-09-03" version="1">MKKLNSVYEEFTNHLSKAAFVTADCELSGLAGDRKGITKLDDYLLLLREGAATYSLLQVGFCIAVYDTEADDGSWILYPYNFYLYPAEVSCPDPCLEAAAPTTPTSLHGCTQDTDMHLNSGTVKWLKQQGFDFARWIDEGVAYQRVDEVNNTGSKTKRQRIACRWGIQRFLEAVSQHGKPLVVHNGLLDLFHLYDKLIGELPTSASEIVRSFGKRFAPAVYDTKATARYLDSKGIYVLDGLFNLEHLYHEMDKTAKFAQTIRIGDTASALDYASLITNPPKPKDPERSSLDLLHEAGFDATVTAMVFTAEIRLLQEADGLPKHFVPSDFTEAISSSCTHFRTVINRVNIHDEIEEGFVQLPREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3F2</accession>
    <name>A0A061D3F2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767442.1">
        <property type="nucleotide sequence ID" value="XM_012911988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3F2"/>
    <dbReference type="GeneID" id="24563797"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204140"/>
    <dbReference type="OMA" id="NQHIARG"/>
    <dbReference type="OrthoDB" id="364908at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="556" mass="62736" checksum="13757C724ECE8498" modified="2014-09-03" version="1">MAEFLARAVNDAPNVTKLKSTLDNKIDGIRQEAENGFDTPSSIFLGPLYDEMLIALGGEDMQNAQKWLLATSFVIKSEDFRYRRGLAVSESASEFFDGIIAKILDTLEALEDKPSVIKDDLWRTLREAFDYILIPDVAAVVKCHRRLANRAFKFVLQTASTENTEQLILRLMRWMCSTRTFDSEKSEDEVYLNQLRVLQSSANDRISKDASDLMLKNVKTLSKRDLKALPAFINTNMKHLATEIELGATENLARPFQLMKATFDASSRFDANVVIDLVPLWRMFDAFFEQMHKYDSNTIKQACDLLTVVAKWLSPDLVLVNIPYLGGIIAKIFDNDVDTLVQHSQCMEDLFAVMNELCPDFYLLASENAVRLIDTLIGDIERSNLKDAHKLIGIIAHMNGEAVGHKVESLILRIVELNDSHWGDASLTQATLRLIHRHLSRGCSKHPRILQILLAFTQHMRTMGEHGILVDRIELEIGEILSTGNATALNADYTLYAEELKAYVELRGTEIQQGGQRDNPDKQDTAPAEDTAKTKRDEVVDAIKKKLKSMRQSAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3J9</accession>
    <name>A0A061D3J9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766838.1">
        <property type="nucleotide sequence ID" value="XM_012911384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3J9"/>
    <dbReference type="GeneID" id="24563193"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109500"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="94" mass="10427" checksum="F4B21A033527BD79" modified="2014-09-03" version="1">MVKQNCQCRTNGNKCQGDGCEECKYWYCLCDCCGRRLGICIGVAFAGAIGFFGLFILVLYICSKVYKMSFGTVIDQIDYALTGYKPATSKCDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3L2</accession>
    <name>A0A061D3L2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="6 7">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0203300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767359.1">
        <property type="nucleotide sequence ID" value="XM_012911905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3L2"/>
    <dbReference type="STRING" id="5866.A0A061D3L2"/>
    <dbReference type="GeneID" id="24563714"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203300"/>
    <dbReference type="OMA" id="LWGGPQF"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="52"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="732" mass="85198" checksum="E7CCF4B034DEA7A1" modified="2014-09-03" version="1">MVVITESDLTQEDIENGLMDWLSDHDESRDADEMERLADNEAPITLSTVFVSTLIVAGLPLVSSEKYDRLLEITRKKLTKDFEKKGLRIHKDFKIEMPVDEAGNTYGVAFFTFASRMEAQKALQQLNMSKFDASHTLKAAMVDDFDRIVSDENSCTPALNTFGFTREDLRSWLFESDRMLDQLVIRYADQTEIHWFDPLEREPVLIYNGERERAQGKRVWTDQKVEWSRNGSYLVFYRRPGIALYGGPSFELKVRFEHRNVQNVSFSPDEEYLMTWDGTKGEDKHENSVCIWHVITGEKLCSFPTPDLSYNGQDFPHFVWNHDGKYIAKLHQSAEGNEIHVYKLPEMTLIPDAEGKPAPLKYAAEKFDWSPTDDILSIIIPGTIDTPARLLLVDIPSRRELSARNVYNVCSSVMHWHPRGECFCLRTTICRKTGKKGRKQFNQLEIFRLRERDVPVDTIKIEDATVKNLYWEEGGSKRFALVVRDEEMGNSSIRFYRVSEEGTARDTVCVTTLELQSQMNRVVWSPSGNYFVVACLTGEGTILFCTLNDNDKVEVLYKDEHFMMNDVRWSPCGRYVATSVRVPLPTHGAGPSMDSFRYSAEAGFCIWTFQGRRLYVSRRENLYHFDFRPTPPPMLENSVIDKIKKNLKEYSRKYDMVDEKAREEYEQQYFAKRKVAEDAFLKQAAKLMEWLVQQDRYLEFKQGWDSFYDETHWDITEDVYEEVIEVKEEVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D443</accession>
    <name>A0A061D443_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767702.1">
        <property type="nucleotide sequence ID" value="XM_012912248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D443"/>
    <dbReference type="GeneID" id="24564057"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206740"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="80" mass="9044" checksum="C9396552104BEC4E" modified="2014-09-03" version="1">MCMGVFIDKSMPNAEPFFDVVPTLSHMCFAFTVKSERVFKYVVTKMECWSLAAFSLLAILVGETRGQTTKIDQTLESKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D486</accession>
    <name>A0A061D486_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0101080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765965.1">
        <property type="nucleotide sequence ID" value="XM_012910511.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D486"/>
    <dbReference type="GeneID" id="24562320"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101080"/>
    <dbReference type="OMA" id="AEHKLEG"/>
    <dbReference type="OrthoDB" id="372438at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600594" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1538" mass="170945" checksum="D0239CD8D078A515" modified="2014-09-03" version="1">MRLPTCIKVVFAACAGILSRAALAHAQGSEHLTAREALKRVDTADNGGKASTEVVFEVAISPRDDKSQPLPFCATLVTTLWFTDNEINQASNAAALFDILRAKFAARARSAELEQRFGLLKRLSAVAYLTSMGKLQIVENNVQNETRNVRFATELVSPLADKSAWEKLTSYTTELSMSVADGECPVTSEGEYADILNDQDPTEFRWIAFGTGAPGATPQAQQVKQEPERSDSQQGDAEPAGNSSMSDGMRIRTDDEAIAASRKRYGIIKEDYVKLSPEEETRYMDLFEGSDRQDHGAESMTAIKVTIKTKVLPISVVLTSHYYVMHSTVLLTAREFKPCEDKEYVKCLKTVRDKLFDRYENEASRKFARGRFISLLQSLLLQYDLYVMPMQPDARGVPELVVFVTVYTTTFANLSAWERLFGEAHSSDGKVDLDLQISPAAVVKPDDALWINLQKGYPAPKYEKLFMEENPQLKLGGQHVRSKQDIMEEDIKRQMAELKKKREDLLYKFAGNEEDEASNETIEPKKEPVHHEDAQPAEGAAKTESENPATAPTTEGPYGAAGQGGAGSTYGQYGAAVQGGAGSTYGQYGAVNRGAAPYAQDENQAGPAHESVVPTEGEHKLDAERKLEGENHDAAHSTYGQYGTQGNEGVVPTEGEHKLDAEHKLEGENHDAAHSTYGQYGTQGHESAAPTEGEHKLDAEHKLEGENHDATHAPYGQYGSTHHGSETSAPTQSVEDEIKPENAEQTYSAASGEHKPEELHGEGAAATAGSDAQVTGYGNPENANMGPGSNAFNDFTHRYTVDEGENGGQNQVVHNIQYTESTPLKPSAPPKPETKEDMRKVVSAYESALMHVPKEIHGYQLAYKDIENYPELQKTWKTGLTTMGLMKEEDELAPFLEKHNFTYDQLKDLFNFTYGVIAVNMYEEARDFYESARIPKESVETSLMMVQNSFRANTGTNITRLPPVVKKMAHACPVRDMIISLSTDDLIDRMQLMLGSWLEPFETEPDLENNFNLAALCSTAAVVIQQWRYLQVYQGYNEEGSAWAVLLQSFSRMGQSKNEQPEVRSHYKELVNGAAAKLCRQYINEAGSVASTPHKGITRNYEARSLVGAVGNILDQNMEASVEEVVTSLSKYFTAASQRKRLGEALGVCISLQVVNKMHQCLSVEHSNDYSLYKLDLITHDAGPILDRLATANILPEGQQKNNLAFVHMACDPRNSAVQEVVDKMFKLLSNDGHPIIIETLDNRNYKHPKVKETGELVEEEGTPGLLDDDYVELEDAETLSKGEEGTEAAKVEDKKQPTSFLELQPRHLVAPASEEEQRKIDIINMLRPQELAGTHGCRGHGAAPGAMTVLDKIMHSNAPYGVVDPADLRTIMFDFRMIPIVDEDDLKSMLVPLVFQKREADYLKLLKAHEYPMVLARKVEERMRNVRQHLPTEDLLHHARAIGSLEGKDEVTISLDKHTVRRNRELNDFKQLLKVLRELPHDGFYFEQADGKELPLHSIGEITAQSLEHRREKPHVIIMQIIDPVHIADNDELYTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4D2</accession>
    <name>A0A061D4D2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0207510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767782.1">
        <property type="nucleotide sequence ID" value="XM_012912328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4D2"/>
    <dbReference type="STRING" id="5866.A0A061D4D2"/>
    <dbReference type="GeneID" id="24564137"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207510"/>
    <dbReference type="OMA" id="EHGFETW"/>
    <dbReference type="OrthoDB" id="10266805at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595777" evidence="2">
        <location>
            <begin position="20"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="456" mass="53441" checksum="BC14FB86E9444BB4" modified="2014-09-03" version="1">MTNLGGVSVLCLCLAQAVASLTQYEERYGSQLRRLPADEIVEEPLNKLAFGSCQKIELNPKRIYDAITRYDPDMFLYTGDIVYAPNGCCEPHCLKHEYNRLNASPVYRDFAASMKRMDGIYDDHDLGINDGHIKYEHREFSQEYLLDFFNKPADHYRRKRTGSYFSMLFRDPEQPKRAVKLIVLDVRYHRDCYYYCSCHTCLWRRMHFNKYFFARTINYLFGFGCNHPGDTLGAEQWRWLEGQLHDSEAEAHVIVSSIQVFTRYPITESWGLLPDAKDRLLQLLLTTKPKNPIFLSGDVHWGELNEKDGVVEVTSSSLTHSFLEQNKSPYRPFALALYMFKRNTFMYNNFGGLEFEYDAKADALKWSAKLFDKDGQTVRHFANDPARDPLSIYRNVESKSRTFFKMDRMVKCRSIVWKLVLIYVFLCVLSWMVLTPYIALRAVHRRVFGTRKRKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4I9</accession>
    <name>A0A061D4I9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0201240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767153.1">
        <property type="nucleotide sequence ID" value="XM_012911699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4I9"/>
    <dbReference type="STRING" id="5866.A0A061D4I9"/>
    <dbReference type="GeneID" id="24563508"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201240"/>
    <dbReference type="OMA" id="QNMSGDP"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="353"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="673" mass="76760" checksum="2EF0DF5A291987E0" modified="2014-09-03" version="1">MKVDGELYQSCVEPEFAHTAAVTSAYFPPLISLVHVNRGGSDALELRLRRNWPTYPANVKESIVLEDVINVLCGSEGTLYHVEHASYAVHRSPILDRSWSTRSRPNAVTENDATLCMMAEEILELAVMQRKVQDFVQDNERGFVVLSLCEVLNVLLQELQSRIAQFDESQRNVGMGLQRFKLYIQPAIHTFEVLQGVIAKSRATGAALLNTLAATCQLYGTGDARRGLANHLFKQAMEAYCHLVDTWISFGELYDPCQEFFVVRKGPPTEASEEEQTFGIDWSRVPNVMKDIAETILNTGMYIRILARSKGKALPNYQPLQFTSVEELKAHVATLHQVASDELVKYIVADCNLMEMLESVHRFLLLSRADYVTNILADLDHNTLHESINLSFQEAVAQSSLRNDAYKHLYALRLVDGSAPLGLSTRPDSNISKRLKLCFTVEWPMQIFFSEDVMAKYQTAFNFLLQLKQTEHALSRIWLTHMKWKRLPLMPSAQLRLNYTFVIVERMLFLCRNIAYLCTVEVTERNFNLMLQTYENHLKNDKAQQSFSFIVSRHHQFVDQVTKDCMIDDEAVAPSINRALSLCNIFATQVLEFLEQRETDSGAARQPDRHAELERATKFTTDLLHNEGYIAMVGTASHQFDRHMRALLALLQGTEERHQSSLLLRLTYNGYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4M4</accession>
    <name>A0A061D4M4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767852.1">
        <property type="nucleotide sequence ID" value="XM_012912398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4M4"/>
    <dbReference type="GeneID" id="24564207"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208200"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="66" mass="7146" checksum="BE4886528B1B37FB" modified="2014-09-03" version="1">MIRYTTVYETPPHLVQITALCIAARGSAARRGLRGAASQRPGREVGLALIRTPNKDGHGSSKDKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Y5</accession>
    <name>A0A061D4Y5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767814.1">
        <property type="nucleotide sequence ID" value="XM_012912360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Y5"/>
    <dbReference type="GeneID" id="24564169"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207830"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600055" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11191" checksum="832EE0CEE2C30E4E" modified="2014-09-03" version="1">MFLCVLVVCGISLHQCPTLTLKAREHSIKRASGTVAYHINGCQSATYSSISDTLPCWRAVAEFRRQGDVAQQSRIWPQVLKECEYCNIGFKYVSKCFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D532</accession>
    <name>A0A061D532_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766260.1">
        <property type="nucleotide sequence ID" value="XM_012910806.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D532"/>
    <dbReference type="GeneID" id="24562615"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103870"/>
    <dbReference type="OMA" id="WITEHEQ"/>
    <dbReference type="OrthoDB" id="366385at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1306" mass="144732" checksum="2337AD1238BCA766" modified="2014-09-03" version="1">MRQTKCGLGRLAEAFFMGCCLLIGREYIMLLADNNADQGKTMYTVFKLITFLTIIAAGDPRCYLPSLITPSVVVQFICSFLVFGLSGGGTYTLIVQCLILALGAVMNTLLLLQAATEFSNNAATTLAFLCGCVFSYELADICNALPWFRRNMFMRLVLREFPSHALIQTKCAAMAAAITMRYALGEQCSFYSVDLWKFYKAHKNAFVEWRTHPLFGLILRERSKKMMPLYTCMAILIAIIGALPPHAQLFKLPLANYRLMYIAGFEEWALGAGVLMGAILPFPRSCKFMLHVTVLVMCLLNTLHVPIYMHFTSLSMLKPYTLTWFCIVTSFLEGYTLSYGIGQLVSVAFLRGCSGVLVSKSCCEAIADAQCFCKQKADNFECRGRYDPSRAGSPGAKQKSPSVSTNHIIWVKQCDNTYNMGRCFPLKCKCTPEPGASSQGKVQKTCIECTMCNKKDGDCKTKELIPVTCTKKIAAVDEKVTKAEENQQNKGGSGDSAGGAGGSSSSPTSPSTPTKSQAAVSLQQSQESLPKCTEAEGKGASASPKAGAAKAPAKEEKTKPDSEKATGVEAKDAAKKKKKRESKCFCKNLLENDCATGCLGCVCVTEKEYEYEEEIEEAKRKAACKKLKCVEWITTQQAQHYVLRNAQSSTCDDCDLTLLLEAVPVGNRSEMCCLSTVEEPPFTCCWQEWNPDMDRLYIGYLDADCPLCSIVEVRTMDFAKEYSQNLNESFCHHFNIRSMEFGSCCHSTLYLKMLCDKRDKYPHLHRRRYEFKHYPISYLYFTTAAVMNEEVEKLKSKRGQSSTASSALLSSTAAASTGSSGAPGAPSGVGGAAAGSAGQISSSGSTPSPGPAAVPGGGNGGSGGAQASQNTGQNVTQPAGGASPVASKPTDNCDENGNLVLSPSTEFLVDQKYKTCCFGVATRLFAYYRYVTEMNGCNYCVTDKCDESRQPVHCDCKGGKCSIGCCVKVQFTDEISTQNIANKYRYISIVCFFALCFVMQLILTYIYHSFTSPSSAVYCDFGVHMQSITKGGWKGAIRAQLADPQSEVFTLQHHDTEKGMAKLVQPLELFIPGNVDSFATWVKAQVASVFPEFARVYDLKMYYTACTALCMYTMRKCFEVVEPLIRLHLQRWERRWEKEFACYKESLVGALEKSAHMSRLAQVMRYEMGSFMYNAVPDLPDGAWTALIDEIKLYQWITEHEQRIQKKRRSGDYDSQLTIRQILNKVWRKRLRLIRRLEEQRRAVFHWQGLTDSYEMLKRFYAQQDLAFGVTEEPADDADDFPVGDDLYSDATPHTDTATQSHTETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D590</accession>
    <name>A0A061D590_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768032.1">
        <property type="nucleotide sequence ID" value="XM_012912578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D590"/>
    <dbReference type="GeneID" id="24564387"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209990"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595986" evidence="2">
        <location>
            <begin position="26"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="300" mass="33409" checksum="D51E9044D04E9A3F" modified="2014-09-03" version="1">MKMHIGAIFGTFVIAYLSTVLHAQAATKKDDNALTFEKFMTKTRGYHGGIPVPGVDFELNMEPLPWNHPRNRPYWRPLYADEIEDRRAKRRKAAAARKPSAGSSSDKSTAPGAPKPSAGSSSDKSKPPGAPKPSAGGRSKKAKTPGAPKPSAGSSSDEAKAPGEAKPSSGGRSKKVKTPGAPKPSSGGRSKKVKTPGAPKPAKRTADAQDANSGSYEDDDEYYDDDEEYYDDEYYDDDDEYYDDEYYDDDDEYYDDEYYDDDDEYYDDEYYDDDEYSGSDYYDDDEYSGSDYYDDDEYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5B8</accession>
    <name>A0A061D5B8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0209070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767939.1">
        <property type="nucleotide sequence ID" value="XM_012912485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5B8"/>
    <dbReference type="STRING" id="5866.A0A061D5B8"/>
    <dbReference type="GeneID" id="24564294"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209070"/>
    <dbReference type="OMA" id="HEVKAFD"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="76"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="292"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="513" mass="57499" checksum="272BAD65EE4F48BA" modified="2014-09-03" version="1">MASQLARVGEAESAPLWVNRIRTLGPQASGRPARELLEQWKVHPHLVRLLEAHNITQLFAVQEKVIPMLLRGDALDGLSAAASDLVITAPTGQGKTLCYLLPIVNSIVQTNRVGFAAMVLAPTRELVKQIHDICAWFVDDDPATYDLRGGELLRVHSCHGNTSFIEDHTYLLDKRPQIVVFTPGRFVEHYMHRETAYDKTLDFTTLKWIIIDEVDLLLSQSFYNWTAAVVAISKQCQVQDRSASDNVFARHRPQKILVSATIPSKSAEIDLLQLHRPLLLKGAETLYSLPANLTQKFVKTTRSKKELVLVALVCRLLSSAVPGEKTIVFCSFKDTAHATARTLEVFSLYTQSNLKILELSARQSQKQRESVLQRFQGNDTMCLVCSDVGSRGMNFANTRNIINYDFPKSVTTYVHRIGRTARANDSGTSYVIVSGKDDERFSEFKAELRLADEDIEQVSPSQLWDEELKEVLEQVKPMVSRCLELEDSGSLAHDAPLPSTWMSLLRPAPEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5D0</accession>
    <name>A0A061D5D0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gliding-associated protein 45, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766360.1">
        <property type="nucleotide sequence ID" value="XM_012910906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5D0"/>
    <dbReference type="GeneID" id="24562715"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104830"/>
    <dbReference type="OMA" id="SKRCGCD"/>
    <dbReference type="OrthoDB" id="339159at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="194" mass="22079" checksum="0E5DBF4AA4819AB4" modified="2014-09-03" version="1">MPLCCSKKAAQRQKEYEEEVRMRKQEEAARIEKEQREREDARKAEIERIMQEEKQAKLMQQYAEEEMAEQERLKQEQEALEAQRRAEQEGMMGDGMGGDMEDHEQYEDAQSMSKMASGVSRASMDATGAVQSEGPGNQDDSFEMQTYTPFDMTTVDQTARYVANKCGCALKPEHKPFECAICQGIDLSDAPLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5E8</accession>
    <name>A0A061D5E8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb-like DNA-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766380.1">
        <property type="nucleotide sequence ID" value="XM_012910926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5E8"/>
    <dbReference type="STRING" id="5866.A0A061D5E8"/>
    <dbReference type="GeneID" id="24562735"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105030"/>
    <dbReference type="OMA" id="DLSVFWD"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF51">
        <property type="entry name" value="MYB-LIKE DNA-BINDING PROTEIN BAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="526" mass="60369" checksum="D5370F4F00F78906" modified="2014-09-03" version="1">MKEEISQLVDSRGRRPASNDDAFKLYSFSSSIPLFRRKYDWNVPKWEPDQIRRLHIAVYNQLTKDLTGGPAGLDSRLKPAEISKISQLLDVSHARLLYGIYLDLGPTRMADVIVDLLRGDNFVSLVEAMRKDSGAFIRLFSTSADSYHEERTTSCVIEAQPENTTVDLASLWSRVADDVNDNGKSTKHKLATECCTIFLNSKPDGSLIETVTRKEITKFRQYTATLPPNDDYLQRGAEIAQELGLTLYQLLKADSRPDQLSSKRWEHHDDERLIQLVQRQVNINARGPKRSNSLCWRTVARQMGNKTNEQCRLRWRAIGNTTLCNEAFDDSQLYMLQILHAAYGDNWHKIAKLMPGKQAHQCRSKFLSCLSQPDRTDYIKYYYDLKNAITNRNAAVNVRKWWARVDCLGMKMLKIANITKNTVIMNVLGDFYRSEEIIRRINRLFGDESLKRTHTLNGVDVLIVAEYLRQYSSHMVCKILNSVVVSLLKKSKSGHANDFRNIFDLGHVDESQFANALKRLLDLSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5M7</accession>
    <name>A0A061D5M7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768217.1">
        <property type="nucleotide sequence ID" value="XM_012912763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5M7"/>
    <dbReference type="GeneID" id="24564572"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211730"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7760" checksum="62EC38B5577D8EE3" modified="2014-09-03" version="1">MSSQAKKDTYGPTLAGIFGGIFALIIVGFLIWAMIDARKWPFEDLHDRIHNDEDIYELYKKMPTKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5T7</accession>
    <name>A0A061D5T7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767558.1">
        <property type="nucleotide sequence ID" value="XM_012912104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5T7"/>
    <dbReference type="GeneID" id="24563913"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205300"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="162" mass="18296" checksum="BDD18F0E28BC0E8A" modified="2014-09-03" version="1">MRYISCFTQHMRSPMHPMAKSFSFFAVNETDVEAESTTKGSPGEPCLESSREFSSSHPISRSTYYAANGKDMGDLHDHIKSSNVTWRFRAGFHRKLNGHPTSNYAIITFFANRLTTSGILKTTRLQCPLKPTKRHTLVQPSNLGHIEVFVSNDIGFVKQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D630</accession>
    <name>A0A061D630_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766560.1">
        <property type="nucleotide sequence ID" value="XM_012911106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D630"/>
    <dbReference type="STRING" id="5866.A0A061D630"/>
    <dbReference type="GeneID" id="24562915"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106830"/>
    <dbReference type="OMA" id="YPHERLR"/>
    <dbReference type="OrthoDB" id="365080at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="273"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="434" mass="49150" checksum="42C934822FC11B01" modified="2014-09-03" version="1">MADSSDPGRRDSVDQGSFRSAPKHRNAGDISLEQIATRKDECVRFLEKRSLDLLSFTYSLSPERAQEFNRVLEGDMDRMLLDAHKQLAMYRLYGAGGDGSFSKYRLNHLETIAREAEECYERFERAKRLNPYPNVTAIVPIFGTDDLERRVRQSLAEQENVNKAFANLKDNCKRLLESSEHVKKMIRNLREQNQLIFFKHLRVSSLIDEVATSLGVCVRDNVAEDLHSACLSQAASEFTVDSWVRKIKECQATMQTIRTEARTYFWGKESDSSADKQLLTEDEQLSSLELPDNVTLRPFDLNDLSRLELTVRAPEGIWRDIPVRFECVVPEGYPHERLRVRCLSAVGVSAEDVTGLQIKHPNILGSNAPKCAGAVCLNIIREDWRPMYTVGTAALGLLNLLVEPQSFEPLDAEAAQLLTSDPDRLRELSLNDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D680</accession>
    <name>A0A061D680_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S14p/S29e domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0301060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768387.1">
        <property type="nucleotide sequence ID" value="XM_012912933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D680"/>
    <dbReference type="STRING" id="5866.A0A061D680"/>
    <dbReference type="GeneID" id="24564742"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301060"/>
    <dbReference type="OMA" id="KRICMIT"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="22392" checksum="74B051BE12636D6C" modified="2014-09-03" version="1">MDLHEGFGYAFVYRCNKHCITSEIALYPRRNRDPSNACSDVIPPFNLDPEKIKAQVLHYGPEIPEGAWSKPCRPPGFCGYRGMASDFRFCKPDSAVMSRMMRRKYKQVIYKHVRTRYKQYIKDARNVSELMYWRAKLDSLPRDSAKSRYKRICMITGRTRSVSRVIGLTRHQFREFANRCLIPGIRRANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6F8</accession>
    <name>A0A061D6F8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0108170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 10"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766705.1">
        <property type="nucleotide sequence ID" value="XM_012911251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6F8"/>
    <dbReference type="STRING" id="5866.A0A061D6F8"/>
    <dbReference type="GeneID" id="24563060"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108170"/>
    <dbReference type="OMA" id="MDIPRPE"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07852">
        <property type="entry name" value="STKc_MAPK15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000238">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000166">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="502" mass="57172" checksum="9CDF98A572B88473" modified="2014-09-03" version="1">MSDHIDEHILSKFHILQKLGKGAYGIVWKVVNKETQEVVALKKIFDAFRNSTDAQRTYREIMFLHYLRKCNNIVEIKEVYAAKNDRDLYITFEYVDTDLHAVIRINILEEVHKKYILYQIIKAIHFIHSGDLLHRDLKPSNVLLNAKCNIKLADFGLARSIAHDEITDEAPVLTDYVATRWYRAPEILVGSTKYTKGVDMWAIGCILAELLINKPLFPGSSTINQLSKVIAFTGMPSEEDMESLGSPFTAMMMSSLTKIPQRSIKDYLPNAPDDAIDLVRKLLQFNPNKRISTLHALNHPYIRSFHKSNDSLAALPKAVKIPVCDNVKYDVANYRRLIYRYIEERKSHQRAHKDDASALAHEHKHAPRSPDAVKEPTNPVTTDKSADEARHTKCTANKERNSYSTQALGNLIATHKNAAKLRPVAEQPAMQANVAQPASRLPIQSWRGFFQNTCGSSVQRNNTYNQPQLVLRQKPQPQPAPAHYQCKVKHQQDSGYSGMYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6R0</accession>
    <name>A0A061D6R0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766815.1">
        <property type="nucleotide sequence ID" value="XM_012911361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6R0"/>
    <dbReference type="GeneID" id="24563170"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109270"/>
    <dbReference type="OrthoDB" id="366245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="126" mass="14110" checksum="AC4186B104EB2513" modified="2014-09-03" version="1">MTHPAASISTNTAIERLLCERVLSNANVHAEALNLNAHIINIQCKSVTSQLLRAEWTKRESVAFIKSVLDRPSLHAHLSQALIEVLKQSFYPRWFVGQGNFQLKRFDASVDGDGVQSPKESVPRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D702</accession>
    <name>A0A061D702_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767958.1">
        <property type="nucleotide sequence ID" value="XM_012912504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D702"/>
    <dbReference type="GeneID" id="24564313"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209250"/>
    <dbReference type="OMA" id="YELWKLC"/>
    <dbReference type="OrthoDB" id="361829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="465" mass="54021" checksum="6007C717A5FB22FE" modified="2014-09-03" version="1">MLGATFTHVRRQCRHEGLIPGFHSTQYRIDPAFLHATSGRRSTVSCAAAPRRTTKSSRIQKGGAKKPPSMGKNKVTLTDEQKQQIDALAKAHIEVTDSPSYIQKLKLNTHSEESSPYLTLFESEKLTKDDLVGIDLPFGLVPPDRYELWKLCGHVCDPLPVISSQSMTPKQFTQRLFGKNERITRDEFNYNIEYKMRFYAPGYGDIFLMDKVRCWRAWFLFRGLKEGREDLPTYHSIHQIARPKDEVPLSAAMLSVNYEVNRQGVHPALLDMLWDFFTDNNSVIRRDEVTAKLNWVVDRLPDLDPGEGISPDNFYKIFIEPAREYLAKFDKEAFAVGANLKANMLPQRQQLRKIHEQSLRQKVLSNNKALRQRYKILTSAYLDEIRSMYKVPTPEFYKQYERRRLTGYFNLLADMQERRMRRRAMSKEKLDELKAAKADAPVQKKKKREKKPSKRNKKLGRGVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D715</accession>
    <name>A0A061D715_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, NUDIX family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768484.1">
        <property type="nucleotide sequence ID" value="XM_012913030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D715"/>
    <dbReference type="STRING" id="5866.A0A061D715"/>
    <dbReference type="GeneID" id="24564839"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302020"/>
    <dbReference type="OMA" id="FIYVHKR"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="201" mass="22765" checksum="101263DC0B4E0DE6" modified="2014-09-03" version="1">MAHDDVLDMSRLSSMAEATEVVLMVDKDDNEVGTCTRKEMRQFNKWHRTTCTVLLSTRGSEVEVIYHKRSSQKVYCPSYNDLAFGGVVTVGESYVDNALRETSEESGLSVSEENLYELGNYARDEECIRCHYKLFVALYNGPLDRLTPQPGEVDEIRSTPLSTIDELMKAEKFTSSCSWIIPRIKEFVKEGGISKLKEVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D749</accession>
    <name>A0A061D749_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0304440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768727.1">
        <property type="nucleotide sequence ID" value="XM_012913273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D749"/>
    <dbReference type="STRING" id="5866.A0A061D749"/>
    <dbReference type="GeneID" id="24565082"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304440"/>
    <dbReference type="OMA" id="RSHSENY"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="227"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="283" mass="33567" checksum="13D1EB761EB38488" modified="2014-09-03" version="1">MSEPRRYRSRSADRQRYARRDSSDRGDRRHYREQSPRRGDSRDPGDNRRRDGEDRRRRDSPDRRYRSDRDYRDDRRRDYRDGRADGDRGDRRGSYGESRREGPVEDGGSATRDDRRHVRDSSYRDDRISPRRGGRDGRRSVTRGDPRGRRGDSRYDRGADRRADRDDRRRRSSRDRSSGRDDRRRRDGRRRSRSTDSACSFGSRVSFGRPEEENNAEEAQADTGPVDEDELLRQAMGFGEFSTTKNKQHLDSDVSGVAKRSKRKYRQYMNRRGGFNRPLSPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D777</accession>
    <name>A0A061D777_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0302920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768574.1">
        <property type="nucleotide sequence ID" value="XM_012913120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D777"/>
    <dbReference type="STRING" id="5866.A0A061D777"/>
    <dbReference type="GeneID" id="24564929"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302920"/>
    <dbReference type="OMA" id="RFIVMRE"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="71"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="27649" checksum="95A1F754AF34346F" modified="2014-09-03" version="1">MGALSSRHDRNGKWRPESAASDCASAIVKAFNGVEPLPADYDDAENLLQMRGGGRSLAYYTGRTAPSDLIDRVFTLTKKNMSRLYDETNFLGGWKDRMKHREISAAKNHILVLSDENGSLIGFISYRFMIISDCQPATEVCYVYELQVDVGFLVVRASEHAQESFRSRGVGKFLMDIATVIGRYVGAKKLMCTVLKLNSRALSFYRSKCGFVNDESDPDSFDCRCGHDHCYHILKLELGGTDAFPEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7B9</accession>
    <name>A0A061D7B9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Casein kinase I</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0305090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768792.1">
        <property type="nucleotide sequence ID" value="XM_012913338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7B9"/>
    <dbReference type="STRING" id="5866.A0A061D7B9"/>
    <dbReference type="GeneID" id="24565147"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305090"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000596">
        <property type="entry name" value="CK1 family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="338" mass="39557" checksum="57632D162D88178E" modified="2014-09-03" version="1">MITRSLEIRVGGKYRLGRKIGSGSFGDIFIGTHITTGEDVAIKLESHRSRHPQLLYESKLYKLLAGGVGIPTIHWYGIEGEYNILIMDLLGPSLEDLFTICNRKLSLKTVLMLADQMLNRIEYCHSKNFIHRDIKPDNFLIGRGKKISIVYIIDFGLAKKYRDPKTAQHICYREGKNLTGTARYASINTHLGIEQSRRDDMEALGYVLLYFMRGSLPWQGLKATSKKDKYDKISEKKIAIPVDLLCKQLPFEFVTFINYARSLRFEDRPDYSYLRRILKDLFFRQGYQYDFIFDWTFLHTAQLMHTMMNEDIERFERLTKDREREAEEPNTRPVLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7C7</accession>
    <name>A0A061D7C7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768634.1">
        <property type="nucleotide sequence ID" value="XM_012913180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7C7"/>
    <dbReference type="GeneID" id="24564989"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303520"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="6924" checksum="951A05DC6E34740C" modified="2014-09-03" version="1">MQLLAGRCQILYKVMDDDEYEDTTKRSELRFRVQRPFSPIGLYNQSCKTINNSPQVLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7M5</accession>
    <name>A0A061D7M5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768882.1">
        <property type="nucleotide sequence ID" value="XM_012913428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7M5"/>
    <dbReference type="GeneID" id="24565237"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306000"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="442" mass="48351" checksum="656C33DEF8FDA2CF" modified="2014-09-03" version="1">MVFNTLTEAPRNLKEGIDWLMALRGTEAEKNLTALGSAVYDLLHDKPSGYTEVPALEKVKPITKMFLEKPELVNQSFVGDVLKKFNEPRDIAKVWFKRFRRGLKSNFCNIVQTKKLQPENMGLYIGRVAYGCDKLVKHLKMPDQYESAYTSEATWETSCSEKPEDCAAVFVGIAPMLWAGLKSLKDATDAVFKKQNSEMLRERLAEVLKAVGYEDSQRRPHMSIPFVYEAVSEVDKDVLDILYDFSGFWAFYGLPSQSGAVAPTFEGECMQPEDPEAEPTFDGEGEQSLIPEAEPTFDGEGEQSLIPEDETSFEGEGEQSMIPEAEPSVEGEGEQSLIPEDEAGEGVEEPIVAEESVDIEAVPAFEAEPSYENELVNSVEETIIAQESANEVNAVKAVGAGKKGGKKGGKKGGKKGGKKGANKGGKKGGKKAKKAGKKALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S1</accession>
    <name>A0A061D7S1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0201110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767140.1">
        <property type="nucleotide sequence ID" value="XM_012911686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7S1"/>
    <dbReference type="GeneID" id="24563495"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201110"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="812"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="941" mass="105862" checksum="2D3F68D5922C5020" modified="2014-09-03" version="1">MVKFSIMKYVLALYAISILSIRFIGALYFDFGNPYDLLISNALVGCDMDMDAIETAAIICPNRVNDTEYVWHPQPRAGNHTSIYTYVSGNDTLDSVPISEVVRSESVNAVLWFKFKVSQTELHYTKEFDQLITVTKHRLMFICGPRDMVLSDELQRHLEQLDSFNEVQAFPWVPGTSLTQEISKIGSGLGVFYLHRRNMYLPLQGCGSRPSPLFDPDMEVTLDPVTYTRSCTADPMSETRIAFVCEGLIEPDGCMKSLINQNDQVVPAPEPQSYWTFNKRGKWIISSYFDGLALPSFHGECRCIDPWTGHVKARIEIRPKTEYSCDIASMLLRNGIRSIPGTWCSVILHPGSTLTIRLPTDGVDSGSGEDLPQLLPKDLTTLRQLKSLRDIDLYDEIPRHQALAGDALELDVSQMDRGEVKLKYHLGKPLTLIGGLNSFVYHWNLKSTNEYLLERIRATVNVSFAFTHEYEMFGCDRRTPGVFHSFASEEYCSTKLMGNGIGPTYECVCDMSLDSGQAGIYCRPDEVLLPENCKSRMYDIFSNQITPMPKSMKNVTLQSISGFQVIQHKSESYIPLSYACMCINEYGYETSRLLLENNRYESQEYTVDREEASITSIPYIVLPWNEVEVSSEDLTKDKHLVLYNIHQKSVKLRVGTTLSMTCAFGRDAQNYVANNSDITTTWLPVQPEVFHYVLTETTHGDGLIRKAYKDAILTTPDGFSVVLYDDPSQENQHLIIESHRGAILISKDPLHKKLVPMAFVCGKAPEPSDFSVITHDMTASDSSSDSISQTTIWPERYTWNVVEVAVEMTDPYMQGCGVTSSLDELFKPETPLIYNEKGEDSGCKIDLQTAGEAAFYCPVPYVLDPPGCFNQVSVNGEVKNLSDISQSLVASHSNHFVTVRLYSSLAGPYETLRQTPPLECRCVTIKGIVLSTIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S6</accession>
    <name>A0A061D7S6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767145.1">
        <property type="nucleotide sequence ID" value="XM_012911691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7S6"/>
    <dbReference type="GeneID" id="24563500"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201160"/>
    <dbReference type="OrthoDB" id="10323053at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28461" checksum="DD000D6BCB5C4159" modified="2014-09-03" version="1">MAYNSLTQAPRNLKEGIDWLIALKGDDFQYHMEEMGAAVYDLLEDKPVGFTEVPALEEVKRISKEFMEQEALKDEWSVKRLLGRFSKRMSKTGLFARRGKNDAKSEFENIVQTQQMDPDAIASNIGRVVYDSEQFLNKIKAPGKYKSAYTSEATWEKSCSEKPEDCAAVLVGIMPMLYVGLRSLFDATALSVWESLNANAEKHMSDVLNAAGFREPECQANMSIADVVKAFKSVDLDIFIILYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T3</accession>
    <name>A0A061D7T3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">REVERSE-TRANSCRIPTASE domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0211940</name>
        <name evidence="5" type="ORF">BBBOND_0212350</name>
        <name evidence="6" type="ORF">BBBOND_0308620</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4 7">Bond</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768238.1">
        <property type="nucleotide sequence ID" value="XM_012912784.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768279.1">
        <property type="nucleotide sequence ID" value="XM_012912825.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769145.1">
        <property type="nucleotide sequence ID" value="XM_012913691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564593"/>
    <dbReference type="GeneID" id="24564634"/>
    <dbReference type="GeneID" id="24565500"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211940"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212350"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308620"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="615"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1347" mass="153641" checksum="3218EDDAFDC22C14" modified="2014-09-03" version="1">MESSQEVQLSSQIDEDGDLMVIDVDVPDGMDIDAPLATVGRRECRQPERRHESRKPVQSGVQGPKGKPTNSKGAGRGGESRPIPQASRKRHQPGTTPAVKGAGNKARNGGPQGQKGNNRKAKKTGNTAQTPPVVVCNAGPSSSERAPVCVQTLSTLQPPAGEVVGNGGCRSPTVYSISSDDFMDVDEEEPEQVGPVRESNNSIAPGTASEVALTETAALPRAPEGHAPQAERAGNTPQMPPNYARLNAKLQFLHCVMRQIDGPWCHWVPDVYKAVVTKYQRMPRGGWKVLAEYANEHFEFHKTHKEVEQMARQVVAKAARSQPTDVGEIASLHDVDSYNALQEDFDRIMAQRLREPGVIRTVKNKRHTMDSLDFTAIRSLDLVVHNYVKHNPVTDMGMLAILYQTAQDCYDKYSAKPSSSSGKKEAAERRIKELEEIGALLLKYKQKVPLEKEDRKRVYRQMDKYNMIADKPQELSYVISRTQEELQKEQDKLKNAKFKKELYNDNRMFELYTGHFYRTLENKQDADESAINEGMMIEYWAQMWVKPNAPHNGEGYLVERPPAENKAGFPTYEEFVTIVKKLRDWKSPGADGIYNYYIKWLTSLHRVIYRLVEEACQQGKVQDDWFYCGITYLLPKNKKPKSAAQYRPITCMSNLYKLTTRCATETLKREVDGRGLRSENQMGTRSNVQGAKEHALANIALNEKHKGKLLATWVDVMKAYDSIDHAYLARVIDNLNLPGWLSNFIKQTIKRWNIEIRWNKNTIMHKKVERGILQGDSLSPLLFVLCLDPLSRHLTRIFPKVELSVTGGRIFATNHFLYIDDLKFFAHEESTMRGMGREVEKFFNDIGLRINRDKSATNTEACASIAKQMEGPETYKYLGVTETSNSLTSDGMFDIILQEICRRTELLAASKLSGKNLSMAINQYALSVINYYIGVIPMDITHFDKIDLAVRRIINAKHGHKKWANTQRLYLPRKEMGRGLHSMVFRAEAMLLRLWLTLSADEVTSTRRAAIMQHFRDTYAHISHIKMHLEGRYGMEFGMEDTTDKSLRDLRVAQNKWLYNRMHVKSTHKVLYAKREDPKLDIEASSLYLTCGILTPEEEANVAEVQDRNLQWMSSSKKCTRCNNGKNVDHLATKCQKLLHLEYTKRHNEVAKRVHSVLGRQIGLPKEKIDAHKIESEVHGKYGWIAYDKTVKTQKTKEYNRPDIILADRRRNTITIVEIGITNQDNLVDTEKFKKQKYEDLIEDLKARQFNQHTKIRVIPYVMTWEGIVTKEHSKYRRDLGISDRMEAHIQRVVIQETHKIVMRDMKPKEDYDSVEDPQAQTGWMPAWMAPVTSGNGPAWIPQPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7W3</accession>
    <name>A0A061D7W3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0212290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768273.1">
        <property type="nucleotide sequence ID" value="XM_012912819.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7W3"/>
    <dbReference type="GeneID" id="24564628"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212290"/>
    <dbReference type="OMA" id="HINIMKS"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812:SF9">
        <property type="entry name" value="MYB-LIKE PROTEIN X ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812">
        <property type="entry name" value="NEUROFILAMENT TRIPLET M PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1932"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1476"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1476"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2005" mass="226256" checksum="FF8579F514FBECDD" modified="2014-09-03" version="1">MAAKSSVPTFNTLKECLEFLQWLRDRKGVQGQLGSRLRRLLEKMYISVNPVQIEAALSIFLNNATAFHAKLCQSPKGWYTGEKTAKNALNALFQCIPKFLAAIYFLRYQVDPNFSAIGGGSWRDESVGMIELYARMRLPLDTIIKRANNFEKYLIAREGYDYGVIPGGFGAGELKPGYKNGYSPASQMAGDLGNLLDKNRHENNMFLDVYSTTVLPNSGYDTANIANALRLVQDFCRIFAEVRDEQDFKSHLYSKDRCMNMRELKDHCAELKRPLEKIFTGGRFSFTGYGRQYDKLKKHNIAKKMASWFKKNLKEVKQKLQVVQPISNIKKLNRRSLRKGAPLPSDVRAELEKYFTNNFFSYGFTFYGYDFRNWSNMYDVLKTDWFDVIDELKIKSGGLDKLVDILNGKECKLKEDKDREKKDGETGKKDRDKEHIDRDEKPDASDGDSEDEDEASEDEDDEESEDEEDEPLQDSDDPSTVKTEATKTEAAKPVVTKAEATKTDNAEPTAHQVAKSDGSSNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKDKRGPDDGQSDTTVSSSPVAQPVQTQDSSVQSPGPAPSGAHDPSSGQEPGGQGSTSDAVQQSSQEVQTGARNSAPSRPQQSVTSSGGAGVGGGSGDPRSSGKSNTCSGNMISSSYLGDGKICFSKSNDDEDIIWNAQRQSMLEDHYKNEAKTLVRMQTRQQRNHPPTQSRYTSILPNKPSLHASRPPQQIVGRPRNENPYNAPQERDADHWDGSAIFLDGRSFTNPVTSQIAMEKAYEAEQKKYAHEWRANRNKFLDNMQKRMMIEAEDEKQRQIKQMGDYLRHVNEHDNASSGPFAGYPVKHRPSALPIPSARHKLPSIIGSAVADTTQHVDDRKTENNFQNAMQQIITKKRSDDRKISEAIHGARDRIEKYEREAENRFKSELRTKEIIERIRKRNEKQMQAANELDKNFEKTTEDIWKTQLQQNVEHIENDVKNEDAKKRLQQKRSEQKKKLEQQNISVDPPTSTPSTLPSQPSRPAPAPSGQNTVGPAGHRRDYYDPKYITRRTKDVPPLQAPVLEGMEITNKLSDPAQEWERKHWDQWKLAEDFRKAKEKQEEEQFKKSLKDAQQKAVNDLNNSWPRQELQGSGLSKDAWFSTPLDGQSIAHLSKPNMTLDLVENTGIEGQILVPHQPTRLPSLPFPQQLFPSPPQPRPLQPRHSNHAPNMNAYASDITTSFEIQNRNFTRLPDLVTIDDPNMANMTDVTGQPVVGVNGKVDISHIPSDSRLNDGDSYHLVGQEVQDDSTIKRRQQDLLNLQNEQLEIDFQNEQRERELLTLKQESEHINDKQKELMQAAQVDADRIRAFNDSQFDISSAPAPHVEDPKIDFSIQTFHYEDRPFNDVDLDDPYANTADILKDELRPAEDKGFSGIPQTNFDLNFAPERIGLEGYDDPGMPRDSPRKADERVITPFGKDECLNPWSIDTSSTDTTSPPASALPPTDHLPTPKTVREMLYWFVGLNTYGLIGTIQKYVEGIFKDFKGDAIEVTGDPDQLTTSCVTAKLTEACLYSATVIYRVRHNNDFKAFATFDFESVYSQFRYSPDPAGLLCQLRDYVYACHHQLQFLKSQCNRDKSLGGWQNCNYGSDITASNSPLQAFLTDGWDSTFETHLFDPCNLCLKSRVRMGFRDEDLPSSQQTGNTLSTILTPSCGGEDPLLTLCSYLNCLTRRTPRTTGELVSFFHNFGNEMHGYASKSLSPLGNSLRTPHLDCPDWDHLGRHDLQAVSGVRGTESLNSVSNHNHDNAHPRTLSTLVGCGSDPDSCHPRMSPITYRAYALYSQSFAHTYLSWTVYLPDRLWESLEKMYYDLKKHNCFDGKSLHSCPVALPLLYTHGFTPPEVGSQLPLTCQQIIAKLKEIVNGKPIASLMTAMDNFLYNIREPFIFTLVALWSTALLIFANTMLYRIDILHIRSHLIRTKASHLIDVKALLSDNKKMMSLYDANYFDDDPNELLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D816</accession>
    <name>A0A061D816_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNARE PROTEIN YKT6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0300470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768328.1">
        <property type="nucleotide sequence ID" value="XM_012912874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D816"/>
    <dbReference type="STRING" id="5866.A0A061D816"/>
    <dbReference type="GeneID" id="24564683"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300470"/>
    <dbReference type="OMA" id="MINEIYM"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="8">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="22821" checksum="FF9DD4FD952E5E9D" modified="2014-09-03" version="1">MVEAKVIYIAILRCNDPPTFLLQHFKLSDLQFLARGSAKSIAVFAAREIAGRISAGENVIVHEDKFDILAHRWESNVCAVCVCGRGYPERVAFSLLQLVFCEFIAQYPDAGEQYNTDVKLNVPQIKVLFDQYRDPKAVDAYTNVADKLQNTISVVHKTLADMLQNEETLEALVNQSKDLSTRTKNVFAKSRKLKRRSCCAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D891</accession>
    <name>A0A061D891_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769087.1">
        <property type="nucleotide sequence ID" value="XM_012913633.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D891"/>
    <dbReference type="GeneID" id="24565442"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308050"/>
    <dbReference type="OMA" id="DEAMGIP"/>
    <dbReference type="OrthoDB" id="362023at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1445" mass="157121" checksum="EAE71637C8933649" modified="2014-09-03" version="1">MARYGGPYMRSSSPYVHSHRCDYVVDPERRKVFYRASSVSPPPPAAYKPRLRNAGAIDSWEAFEDVLDAYGKDAFGGIVDAYDAATAASSSSVETSKDFSCCDYDNYISDDREDDGYDSIWTGDGGGYPPHVTLEKVEPRSLFGMLGPELNRAEYTWKPSSAVTKLQTTGADDSPCQAEDFQEAIDKHASGMTYVRPQLGFLPKDTTSVVSDTHEDAGLQLSQGETEYEKPKRSPVRSLFGTMRSLRRRAQDKSQESAASRETSQGTLRRSDSRLGERLRQRASSLGGKKDDATPSDNATRRLRANVTHLEDVDASAAELLRGVLPGRTPAQHSQAALSSTVPPPTDDAPPVLAIPKSLLRKVLPQGHDADDPYGSKVVAKAEALGAAMDVAKKPMLPPALAEALESEVMPVAEGQARNIFRMRYDIRRALDSTNNFVGAKKLRATAGPGSEHLRDAVGRGQDVSQLIKKSWKRDLPWETVPDMPEFVMGLNAPTLDVDGIASGQDEEMPSNIEISRMISSKSIGQEEAEFGRKMTMLCSLAEDSDGDLFEDSDDDASPVHGDVVRPGDVREPMNIAAELIEDSVAEVMRSWRPATHGAGSLRDALESAPEIKPPTLWVRSGVTGVTEEILMPRFMRGPFAEVNFEEAPTLSPTASHVSDEVKSEIGSESPEHVSVSAASASRAPSLKSDDRSVRTSVTGRTQQDDHSHAGTASIPMDTDEPVPSDSPADYVSIAKTSSRSVSWMAPSVFESEIDIADEEVPLSSKTSSKQPSISSSRTPSRTQSIAASEKAMSSRAQSMVESEKAMSSRAQSMIDSEEVPSSSEGTVPTPRQDGLDAPDFQRIWRLYTQQPGKTYTTESMLRGYSDGALLAAGRRSIAVSDDLLSGYVGLTIPEKRESERSGESDAVSRVASSARTGVSSRVPSPHVSSEEVAEMSEVPDEALLSPHESTPEDQPTSSSEAEAVSRLGTGTVSETALEPEDEAMGIPEEPDEMETAQEADTYPYELEDEYMGIPEEPAEMEPVPEADTSPSEPEDEAMGIPEEPDEMEAAQEADAYPYELEDEYMGIPEESAEMEPIAETSQSELEDEDMDKPEEPAEMEPIAEEDEPKPEHVDSSSGEPEEPAEVEPETEEPAPKSEPEDDILDEPEEKAEAEPEAKEEEGDPTDIPPVPDEEPSTPEKQVDEGDSDSGDDKKKKKKKKDKKKKKKKKTKYSEDNIEDRPRPLRHLVDKQLKDGFSATVYIVTSKKNAISTLCTVRFDYEKDRLILETPANVFDIDATRVVAEEIPTLPGAPVLLKLTVHGKRSSAIVIQSTSERNLDVLGGTVGWANAVPHAGQEMEAQFDGALHGARVGDPEHAPDATNVSRQHTVDALMPKSASQRLSQDTASTGRNRTESSDFAEHQDGEAPSLQKGASPSAQPADTGTQKRGLLSRILLRKRINKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8A2</accession>
    <name>A0A061D8A2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein pelota homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0308200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769102.1">
        <property type="nucleotide sequence ID" value="XM_012913648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8A2"/>
    <dbReference type="STRING" id="5866.A0A061D8A2"/>
    <dbReference type="GeneID" id="24565457"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308200"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="378" mass="42856" checksum="6B5329AD0C833932" modified="2014-09-03" version="1">MQVHKRSRTPSGGIVLAVTAENPDDIWCIYNLLAEGDEIVVFTSRKVKRENVSSGAVSQEVKKFNIHLSIERITYASSDDDLQVSGKNISDNPYVKIGQYHTAEIRLHSKITLTKQVWNSYYADKLREATDLAGQAEQAFLVLDTGKASLFLVLRYLTKEAFTITHNIPNRKISDIRYSHHQKAEESFFKAVIQKLHDSINFEVTRTVIITGPGFTKTSFYEYLRDNLIRLGYNDLHRHLKSFVVCGSTSSDRRAIGEVLSNESFAERLCSHHYVEHNRAVEALRKRLEANDDTVAIGLEDVIRATELGAVETVLISEDLIRKGSTETRKRVHKFIEDAKNQGARAFYFSDEHFSSEFLRTLTGVAALLRFDIGEAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8E5</accession>
    <name>A0A061D8E5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD domain, G-beta repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769157.1">
        <property type="nucleotide sequence ID" value="XM_012913703.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8E5"/>
    <dbReference type="GeneID" id="24565512"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308740"/>
    <dbReference type="OMA" id="RISWAPN"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1704" mass="184923" checksum="D340906ADA2DC494" modified="2014-09-03" version="1">MRISRVSQCCGTRGSLSSVDFQPHAKPRTVHRIATAAGTEVQIWALWRDDAGTKKSALKCVCLYTFREHSPYEVATARWSPNGRYLASTDSGGTTHILERSDEKCRQLEHSLGCHEPAGNADAASPAPEPEAEATTTKVTRKFTFKYDGTTAKRQRQTGMPNRTKAGRTRISYDSQSVKTEVVKPVTVESNGGNFEAWKSIQSFRCPSRMGQLFDISWAPDNRSIVGGGLNGQVAVFDIFTKQVVAHFDVFEGQIADSIAHSRGYVKSVAWDPMTLYIAVQTSGREASVWRRSPPNPEGSAQKWNFKRVFHDTDLFQKSQCDVLGGSRISWAPNGQVVAFPSAGKATLNFAACFEVVHADLSRDIAVLRDGKPDHRRLQLAYDTADHNVRQDAMLLHGHPARVRNVRFSQDLMVPQKRGLCKGATSSDSDRFIFYAQSSDDGTISIWRFKHASNWDSQYKNEVQCICVIQNASDEQSSLEDLAWGNGGRWLAVATSQGGIILVELGEEDTSTRFHSNWMDGLKIEDAHEVTTDFLNKVEQYQSKKTPQGSSESSAKEQSGSSSDGKSATSRRSVGDVAAATATAGSVAWAAASDVHRYAAQYHPASGGTPYELVSAPFALKDHIHGVGEVAERQLMHCVTAVLLSTLVKALHGIAEACVAATAMLICHVYRTLPISAVPALCRSAAGSNSRVLQADVDIASRPSRFGQGAGLAAIAIRGIQAERVGTVDSMRLYDPDSAEPCLEELEFGRHYLGSTEYGSLLPPLTNGFVGPGNVSSSYPGGNMAALHAQLKSGTVESAVTNAVKETSPSRRDTSASRQSDKAGKARETTLDTDIVSSPTSKTGGNKRDASERSGSSPRGRGRPPSRRPKTSPVTEDRITDIWLSMEYPQDDDLAELLKCIDKTVPAVDPKPQKASEQEPVTPAEPETSQNAVHTDKRGHFESAVSDVAKEVEETSIETATAKATKGRKTPPISTAEKETPAHQGSPQFFILQEAVPHQKSSSLKPSPGGLQYHVSSSRNSAINSPLLTGGMGYLSSIAGSDLASPLLTMAPPMSPIWAGSLDSSTNIQATFGPLVDGPQHKAGVRAHLRTVPAPPPLQLDQSKPPPRLEGLFEVPLIRPSLSVQIQGANKQVVVINRANTMCSALVACVERNGDGTLRMQWTKQVSKGYATHICPVQSEGMVLIVTQICRKSIQRDTHDPAECLNARGSPVGGGKAVDLGPAKRNAKLSFTTFFTLMDTLTGATLIDGCPISNVNVARINVFPCGNRIYAAFTATKGGIALYIFYRKLGCIAWTVSPNIVISANDFLKSGTCADIKQLQMLCVNLNAAQSSAPKNTALGFLTTKEKQEAESDNNEGTEAQQMGVATAPNDGDRKGNHRSKMRRVVTGKERDTTFVAILVYMQEPQVYVLTQYYEPFLIDLTQVHRLFRPQKPAANVMSFGSLCDTYRCELGLIQGADVGGDALFNDVVHRLVDVFHLDPTLKDHYPSAKTEKSVEDVVVEAALQRDRLLAAMLVLGSRSEYILQLHEHVHDMVARIQAAKLCDIVAQLYKRSIEWCANGWRGPRVELTGFDARLMNVIGVDVSAILHEFLLPLLWDLYVALEEECKARGMEPVENRPDPVPAPQCPGRCHKYCTAASARCPISRARKAIGNTDTTSDDELKPLREVSVLCCVMCSVLQVCAAGLHNAAAWERALSCAQATFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G0</accession>
    <name>A0A061D8G0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0308940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769177.1">
        <property type="nucleotide sequence ID" value="XM_012913723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8G0"/>
    <dbReference type="STRING" id="5866.A0A061D8G0"/>
    <dbReference type="GeneID" id="24565532"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308940"/>
    <dbReference type="OMA" id="QYKPIKG"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="375" mass="42953" checksum="16C53D6B50276F1B" modified="2014-09-03" version="1">MVRQRISQLFMNASKAEETKKETVALMEALINGGIKVKSAAEVGKRAVEYTRGDEISNWILNNKQTVAKLRRHSPRLRLPDRCRFYLPRAIEGTIEKTASGTFRRPMWPKRLIKTQKQRFDKVGFYIISYEGNQRWNYVMLTAMILGIFAVCMFQTWPLALKLGMWYISVVLLTILISLLMIRLVLFVSLWFCGFDFWIFPNLLDEELGVFDSFKPLYNLTRRTDTVYMLCCRVLCAIMVAASIHELGKTHDLKDVGNFARQSFLEAIEWGRNKLTAVPEETPLYKSIGVDMSTEFDAEGQNEESGEEGLDDDDYKCLLACGYRSLGQLLKECMLSCNCMEELLANPCLSGCPEDTIRVLTESKTDICRKTRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Q0</accession>
    <name>A0A061D8Q0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766311.1">
        <property type="nucleotide sequence ID" value="XM_012910857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Q0"/>
    <dbReference type="GeneID" id="24562666"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104340"/>
    <dbReference type="OMA" id="RCQKKER"/>
    <dbReference type="OrthoDB" id="366268at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24500" checksum="2FE8097373F143A4" modified="2014-09-03" version="1">MATVLRAGLPRLGLDPDEDIVDYLIALIEAEGPEGCAEWLESAATGDHGDAARELAEAAFAELSGTPAESGGARELMSPIVSSGAAAEMGDPLDSLDVAIDEAKAAGNATRTTGPGSGWQQNSNLDKGVRRELVQRYACFDLQTVHIGEDGQVCSSGTTTRNVEKEVAIPTNDNAARVAQEQYARRMSQKQQHLEAQEKQRQQKLKQQQHDEKERMRCQKKERQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z4</accession>
    <name>A0A061D8Z4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768628.1">
        <property type="nucleotide sequence ID" value="XM_012913174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Z4"/>
    <dbReference type="GeneID" id="24564983"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303460"/>
    <dbReference type="OMA" id="FPHANKF"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="298" mass="32574" checksum="834456E6ABF291FC" modified="2014-09-03" version="1">MAPLKFEKLICGSSVDLLKKDFAHENLWELEHTDAQKGSNFVNNLKLNKDGNMLGSTLIKGDIGTLHAELKAQNSGAHYLEVSAVHPQYTPMTVHAKCEIDVPKGTYSGEVAADHVLPMNSSQLKVQPFSRDYSAFSFTNFKLNCGQVYAGAELTGKNCSLLTNYTGALGYKKQRDDKTYLVAARLFGAREYGLTSLVGNIYAGRAHGCAQNALAVALEHSFKDTTTKLKFAGLWHITEPHHPTPAYVKGRCDTEGNFAFTLFQRFSSNLAAAVGVDFNAKESVSPSTANYGFKMMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D905</accession>
    <name>A0A061D905_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767555.1">
        <property type="nucleotide sequence ID" value="XM_012912101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D905"/>
    <dbReference type="STRING" id="5866.A0A061D905"/>
    <dbReference type="GeneID" id="24563910"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205270"/>
    <dbReference type="OMA" id="ISMVMAR"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="153" mass="18039" checksum="513E968B240A4FD7" modified="2014-09-03" version="1">MANIEDIQFEIDRLKQEYEEATFYATVVLVSHALGIRNYQPSVKVQYDYACMLMCSMQSNHINLSIELFEELLRIRFNSVQCMYQLALCHMRKREYKKARRHLDMLLRLEPRNHAALSLRSLLFDILSDDAMKGSLFVVMASLCAFALYKSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D932</accession>
    <name>A0A061D932_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768673.1">
        <property type="nucleotide sequence ID" value="XM_012913219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D932"/>
    <dbReference type="GeneID" id="24565028"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303910"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="131" mass="14342" checksum="C4D3B921ACF9DE7F" modified="2014-09-03" version="1">MVDGQCPSLRCVFMRGCSSRKIQCTNPKCQCTCCKEKCKKEPGTCSPPAPPSLPSQEHSVATENHASRPEALKIESKAPPSPPNPQAIAAVIIAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D955</accession>
    <name>A0A061D955_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor 2, EF-2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0205920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767620.1">
        <property type="nucleotide sequence ID" value="XM_012912166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D955"/>
    <dbReference type="STRING" id="5866.A0A061D955"/>
    <dbReference type="GeneID" id="24563975"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205920"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="17"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="833" mass="92833" checksum="26441027F481105C" modified="2014-09-03" version="1">MVNFTVEQMREIMGNPKNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAAKNAGDARFTDTRADEQERCITIKSTGISMYFEHDLDDGKGMQPFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIRPVLHVNKVDRALLELQMGPEEIYMTFLRCIENVNVIIATYNDELMGNVQVYPEKGTVSFGSGLHGWAFTIETFARIYNTKFGISKEKMMHYLWGDHFFSKSGKVWLSEASPEAPDRAFCNFIMKPICSLFTNIMNDNKDKYLPQLKSIGVELKGDDRELTGKALLKRVMQIWLPAGDVLLQMIVSHLPSPFEAQKYRVENLYTGPMDDEAANGIRNCDPDAPLMMYISKMVPTSDKGRFYAFGRVFSGTVATGQKVRIQGPKYVPGEKTDLLIKNVQRTVLMMGRYTEQIQDVPCGNTCCLVGVDQYILKSGTITTCETAHNIADMKYSVSPVVRVAVKPKDSKDLPKLVEGLKKLSKSDPLVVCTTEESGEHIIAGCGELHVEICLKDLKDEYAQIDFIVSDPVVSYRETVGAESSITCLSKSPNKHNRLFMKAEPFAEGLAEAIEENEVTSRDDARERANLLADKFEWDKNAALKIWCFGPETTGPNLMVDMTTGVQYLNEIKDHCNSAFQWATKEGALCDENMRGIRFNLLDVTMHADAIHRGAGQIMPTCRRCLYACELTAQPKLQEPVFLVDINCPQDAVGGVYSTLNQRRGHVFHEENRAGTPLIEIKAYLPVAESFGFTTALRASTSGQAFPQCVFDHWQLMNGDALEKGSKLNEIILAIRQRKGLKAEIPGLDQFYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D999</accession>
    <name>A0A061D999_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767675.1">
        <property type="nucleotide sequence ID" value="XM_012912221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D999"/>
    <dbReference type="GeneID" id="24564030"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206470"/>
    <dbReference type="OMA" id="SEMAEMY"/>
    <dbReference type="OrthoDB" id="379364at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="467" mass="54060" checksum="A8108595D222B87F" modified="2014-09-03" version="1">MCRYNAPPKGSRLAQQLDKLATDPLNSSPWEYEQSVVDSFSKEQCASYRFLKNEWAYLDHSMDPHQPAGVLEGGSANYTGKGLRLEGGCDRQRTERMPYYKDHGVRWRERTMMGAVSFTISPDANQDVALNETDLDLEARQWGSWSRPMYSYLPVLESAFRSRTRIENPTDLCYPWLTRHDVFERMPIHVEHGASFIPEPSPDMVLAATGHFGGYMRRPFELPSEALRRQNRLLTEWDRLDAQYAESQDEEVAERIRAIKNALFGYDNMIDNDSNAYTTAVDTAILLARRLMKEQRDDPAHNPDVIDYYLNYVPDMTSVTGGRSRYRGPGKTVVLCLAGYYPDPKYFREYTSVEELAEGYHRLMTEMRYEGSVHTLSQMVVEDEVHDYVLRGDRRKFPRLMAEYTPLWSHRKFGPEFGDALKRGHRIPESELTSFGTKLRKRRRGCSPEERAENFVDDYACFSEECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9F6</accession>
    <name>A0A061D9F6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0305300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768813.1">
        <property type="nucleotide sequence ID" value="XM_012913359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9F6"/>
    <dbReference type="STRING" id="5866.A0A061D9F6"/>
    <dbReference type="GeneID" id="24565168"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305300"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="36797" checksum="381775D240996223" modified="2014-09-03" version="1">MADPSAEDDRKVLVKEFLDLDELKEREAKSRAVVLEILGDIPDADVAPPKNVLFVCKLNPVTEQDDLKLIFSRFGPVRSCDVIRDYKTGDSLQYAFVEFETEEACNDAYFKMQNVLVDDRRIHVDFCQSVSGFWKRFKENGTFTREVKGGPSQAETTRQGQWRRDYDRYRRQRGPVRDVRRQEYRNRGAGRDMDIEAMAEIDQCTVGAAATVADQAVLCPALQVTDLVCVVEGTLGISLGTDHKTATGIVIARDIVTGHNALHIDGTASVIFHEATHRTAPQVAVGPMGAANKRRKTTFTVLPYIGLPDTPNLMTFTMRTAQRIKRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9M1</accession>
    <name>A0A061D9M1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769562.1">
        <property type="nucleotide sequence ID" value="XM_012914108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9M1"/>
    <dbReference type="STRING" id="5866.A0A061D9M1"/>
    <dbReference type="GeneID" id="24565917"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312790"/>
    <dbReference type="OrthoDB" id="367049at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68681" checksum="956490FA54A144FD" modified="2014-09-03" version="1">MIQRIKSGLKRLAYAVKDRIRQEVHTVVELLKKRVSEVKMKLEGITASLEKYVKELGTWMDEAKEYINAVKKYVEEIMKQLDGENRKKIDKAAADIDSVLSEKVGELNKWIETAEDIRQKAESTAKEAYDKLQVHEELSKNVKKIVDAKNKIDEVSKHVTGQLGSLQQWNEKAKGVVDGAIKKAQEVHDELQSAVVQKVEGIGQDSNAIKAASENLGKEVEDLGKWKNAVSNVIVKADKKCDEILKKVKTSNDGTIFTQAKELQDKGKQLLTAASEAKQKVEQRIKDALEAVKAMDADLKRDLKEVKDKIKEGIKDVMSELKVGDLGKEVEKDLKELRERIEGLNKGDNLVNDKVKVLKEEHEKVKEKSSQIKEQTEKRLDSNFESAIKTPLEKNVQAVKDAIGKLYKTINPDGGDAGGKKINDIIDHIKDKVGNILNGERSAEKKGLQGIANGLMESYAGAFRRNFGGIVQGWVSDSVLMYNGVVWDSLKWQGDKTPKDVAGIAGGVKSKLTVEIKEGEKVFQNSRSTDAGRKITQTLTEVMNACQKFADALDGKIHRNTRGNVSPIISKVEGVSELKPARGRNSLKPAEAVLCALSTASRQVSKEIDSILLDKSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA22</accession>
    <name>A0A061DA22_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766781.1">
        <property type="nucleotide sequence ID" value="XM_012911327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA22"/>
    <dbReference type="STRING" id="5866.A0A061DA22"/>
    <dbReference type="GeneID" id="24563136"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108930"/>
    <dbReference type="OrthoDB" id="363363at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="164" mass="19277" checksum="4B71DDE75D59E87D" modified="2014-09-03" version="1">MWMHHLQDRYGKKFDCEPSAAEPDPFREESLGNVRRLWVPPFFDGDFLRHGSADRKVARRRGWMLCLCSTFSICAVFYMWFHCYKASCRDCSLVAKDLSEATDGEVECHCSNCIVNFFFSPQTHFEKCYYSLLFFSGLVVFYIFLVARSLAFQIFRHSNLAQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA58</accession>
    <name>A0A061DA58_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor of growth protein N-terminal histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767970.1">
        <property type="nucleotide sequence ID" value="XM_012912516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA58"/>
    <dbReference type="GeneID" id="24564325"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209370"/>
    <dbReference type="OMA" id="MYHEMET"/>
    <dbReference type="OrthoDB" id="365652at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor of growth protein N-terminal histone-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="275" mass="29547" checksum="89D3F094E301B4AB" modified="2014-09-03" version="1">MDASDDVTDDLLGLPGFIRRNLLLMRELDTKFVSLLDDARKKEQVLLSKLQAQTPTSSPAAADKTASKREASTSPIKRQASDEKGSGPAKGRGSKQKQAAESKSKPAGGDTKRHCKGNTPAATESGSTPTAIAPTGPPPDSVTQEEMDDIQKTRMDAIYLMQEKLAINDQVTYMLKHEYENLKVLFDNMYHEMETSGQMTDKLRMSFTVTKSKPPQMDTILSGTEQELLGNAPGSAGGSADMTASRTPAWISVVPEAVASSIPTLGPKSESKDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAQ1</accession>
    <name>A0A061DAQ1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="10">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0401200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769814.1">
        <property type="nucleotide sequence ID" value="XM_012914360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAQ1"/>
    <dbReference type="STRING" id="5866.A0A061DAQ1"/>
    <dbReference type="GeneID" id="24566169"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401200"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="535" mass="58105" checksum="F856A6C62FA5E315" modified="2014-09-03" version="1">MSHLLNLPVLLLKEGTDTSQGRAQIISNINACQVIVDCIKSTLGPRGMDKLIHTGNDVTITNDGATVLKLLDVAHPAAAVLVDIAKSQDDEVGDGTTSVAILAGELLTEAKQFIIDGISPQVIIKYFRISCERALDHIEKIAVNLSGKDESEKRSLLVKCAETSLNSKLLSGHKTFFAEIVVDAVMLLDSYLDQDMIGIKKVTGGSCRDTMLVKGVAFKKTFTYAGAEQQPKKFINPKILLINIELELRAEKENAEILIKDPTQFQSIIDAEWTILHDKLNKIAEMGANIVLSKLPIGDIATQFFADRNIFAAGRVEPADMIRTSKATGASIQNTVNGISTDVLGTCGCFEERQIGNERFNIFEDCPKTTTATIILRGGAQQFIEESERSLNDAICIVRRATKTHSILGGGGAVEMELSKMLLAYSLTVVGKQQLVINAFARSLEIIPKTLAQNAGFNAIDVLSKLRREHAVSKEAVNWSGVNCLNGDVVDAFKECIWEPALVKKNAIYAATEAACQVLSIDETVKHASQTPPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAQ9</accession>
    <name>A0A061DAQ9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L24, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769824.1">
        <property type="nucleotide sequence ID" value="XM_012914370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAQ9"/>
    <dbReference type="STRING" id="5866.A0A061DAQ9"/>
    <dbReference type="GeneID" id="24566179"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401300"/>
    <dbReference type="OMA" id="CWLCSSN"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="3">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="23021" checksum="E8E6F69A693F3CD2" modified="2014-09-03" version="1">MRIDKCWLCSSNIYPGHGIVFVRNDSKIFRFCRSKCHKHFKAKHNPRKLKWTKAARRLAGKEMVTDDSVEMERRRNVPVRYDRNMYITAIKTIQKAERVEELRKILMRRQRRRALIAKKRTLAEKELETHSHILEVPNDLLERREMDGEDVVMESKTKRVTRHMKVSKPKELVQVRKTIKKPRRSDDAMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB18</accession>
    <name>A0A061DB18_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0402270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769924.1">
        <property type="nucleotide sequence ID" value="XM_012914470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB18"/>
    <dbReference type="STRING" id="5866.A0A061DB18"/>
    <dbReference type="GeneID" id="24566279"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402270"/>
    <dbReference type="OMA" id="KAFCEIQ"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="10">
        <location>
            <begin position="633"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="630"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="731" mass="81259" checksum="CF590E01BB7C307E" modified="2014-09-03" version="1">MAGKSAYTGSADTALREVKHLIDEGQLAQASRLCHKAIRVHGGVNELYRAKCYCDIQLSLWQSCLDTVGWLHLFVEHPAVVYSGNKRCPKRLRTENRQRREEQHADRLEAVRGAAGTHIANGECQWLHFEQAYSYYKLGDPERALIALRMCSSDERPRVLHKSNVAADSAEASDDDVHLDETLSPKYRFLLAQVYVRLGRYSAARALYASALASKNDPLVALNSLSTDLNLVPELDDASRNSIFAAIERGITEKSGTGDSLGYEYFYNWAIAKLLEGDFESSQGHLDVSEERLTAELQNDLGEKQTSKDQPEYAALGALRVFLLHRRGCHDLARTHSDALLDSFDSTEGVDPGVLLILRNNALCLCGQDADTSNLMLKMELLLKRANVVCKFTRRELLDVHRNIVLRLLASGDISACRRHLLKFVGRLRHDDSLHNCLACAEYVEGKIDCSINVLKRGIAANPGSLMLIRSLLNVLVATRRFKSALHTAQAYEATLSGGDASGFYWWVVMQCHINMGNRQGVVEVLSRLVELADCAETASTMQQGCRFLESQGMHSEAAQIYRHLHASNPENATALCGVLFNESFLPGAAGATQCTLPASFTGPLFKELRYIDPEDLEAAGTLSYVRQMEEVRKPTKSRKRRRAPKVDTSRGPPDPERWLPKYQRAAFKKQLKRRKDMHKGQTQGATGAATSNKPTSVTISTDAANTRFGLVISYVIRLQAPPRQEEVSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB22</accession>
    <name>A0A061DB22_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770057.1">
        <property type="nucleotide sequence ID" value="XM_012914603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB22"/>
    <dbReference type="GeneID" id="24566412"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403590"/>
    <dbReference type="OMA" id="RGPFFFR"/>
    <dbReference type="OrthoDB" id="365182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600757" evidence="1">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="225" mass="25092" checksum="DC3BC97D85FDE56A" modified="2014-09-03" version="1">MRVSSVVAVALCCAACGLSPAAAFSTRASSTALESFAPLHHRTPAASVQRYRTFARGLGEEDGVDVDTDVLTGPRIDRDGRIINKKKKLYSYGALEHVDDFFVGKYYVEWTVRGVREKLRFRRRETGSPPLRTSRFRFAGIGGFILRLWLDGLPSSKPGHIALSFLQQEHWTTLDSPLSISVGKFTRGPFFFRSTPYFAALKSFCPLEEAIDNNTLRIRVGLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB50</accession>
    <name>A0A061DB50_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0311100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769393.1">
        <property type="nucleotide sequence ID" value="XM_012913939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB50"/>
    <dbReference type="STRING" id="5866.A0A061DB50"/>
    <dbReference type="GeneID" id="24565748"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311100"/>
    <dbReference type="OMA" id="RYMGGDE"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="35"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="373" mass="42372" checksum="D48CBB557928C4D8" modified="2014-09-03" version="1">MAQGGQDSAGRRAKDSHRSKHKSKHDATDSRRRHQAARRRPEEPERTTEGNYRDRAFERSQLKDEYYKKIVEEHALLKAQTEEESRYMGGDEEHTHLVKGLDYVLLEKVRKSLAPKVAAERAAEAAAAAAGEEIGHSDLGRYIYRTFIYHTHMHHRQFHQRLSKTYSLVCQGYKFKRKDADTQTFYTLDLSMEPSANDVPSTVVSKGDPEKAPEIAEALQWHQENRKKPKEERLHARPLKPAHGGSGDDSDDIFADAGEYRSNELNTDEVTRLKPDEKYFADESDDEGANETYQGPSRLQVLGRRKRTAAVADGYDECYPCAADVDSDDETGGKGKKSRGNRAEWRKIEKIIADKAAIPMEQLEKISAAQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB72</accession>
    <name>A0A061DB72_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769413.1">
        <property type="nucleotide sequence ID" value="XM_012913959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB72"/>
    <dbReference type="GeneID" id="24565768"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311300"/>
    <dbReference type="OMA" id="CANESHI"/>
    <dbReference type="OrthoDB" id="365341at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="786" mass="85959" checksum="C5D7B515C46C9989" modified="2014-09-03" version="1">MEPPVFGAMSPHSKCLLTCVACRLGRDAARAAQADKLVERVFRDVTSTKALQLLNLELINMLLVASYTLGLPLSQPQMQRVLDQTCQLVERDANFNVELTVSILHSLGAIARVYPRQREQLATSAVVQSVLSGFRDFEPRLNMRELSLVLYAFDKLHVVDHAMAEVLVERVEKERSTLNGQTQATILFACAAHPPLHRVLGILRENVVDGAPRFTGREACNVYCAYLKAGLWDEQLSALLEHALPKMNAQELCNVVNLMIQKEAPVDKSFTVAYPRHLNTALMTMRLSLLDALTLTQSVAHWGLASRMRLSALDNAISKALAADRSAYSAKHVYLLHYLVTLGCRGAAQRAVNCAAQRFDPRALSNKEIVVLYNALWHFGSGAACVSVVERELKRRLDQHQAFSAVDLQTLAHWGDSETCGLIADKYLDGSGCANESHIKLLNTLLRKTGSDAARALARRAVEVVLKPGRDNSTKMAVNNDSNAHEDAGSGCNVMSSVSSKHGSNVEVPSTVRHQAAACELLPYLQGELDVVPILSNLVESWLHTLCGDTKIETRCLIACLSVARKLNVRSTSVASVASAIVEQLDGGIGPQDFLDYINAVYHLEIAVNDPGALMDTAVKVLEEAHDEAVKESILFTLSAMQFSGHLITNGVGEHVVSRCLALRKPPRMCLKALYMCLVHEGYLTPGGITTSPAFIRRLQYRAAEVGTGGKTRTESHIGATSHHRRSRPTTHEDNQNEVHCSVYSTLQKIHAGNPCSSIRAEAPVAFDYVSDILLTTSPPRLKGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB92</accession>
    <name>A0A061DB92_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0201670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767196.1">
        <property type="nucleotide sequence ID" value="XM_012911742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB92"/>
    <dbReference type="GeneID" id="24563551"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201670"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600225" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="828"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="957" mass="107986" checksum="CBDE7CBF5A67AC9A" modified="2014-09-03" version="1">MAKFMGLPLAVCAISLHFFGFIDAVEYDFLNSMTSLNTNALVVFQINMDDIGIATLACPRQVNGTEYVWHPQPTADHDVSLKTYVIEDGKFHSVPFSKVVVTEAPLPYGWKVSKESQAELHIDLMDDHIYAITEERLAFICGPRNLVLSDALQARLARLREIDERDGYLWDSTALLLDEIDKIGKSLGVIYLHRGLKHKLLQGCGSRPSKLFAPDDDVAVDPITNTRSCVVDPVSESPIGFICQGRIEPDDCMRYLLDSTGRVVTAPTPHLYRNLDNREKWVIAQYFNGVALPRFNGECRCIDPGTGHVKARIEVRWKTEYICDITSMIARNRFNPIRGPWCSVMLHPGATLTIKLPKQTVKSIPTNEEFEEDGDIDEDALRVPYSQLPSTHAYESEFKPDTELTLRQIQTLYDINDYDEIFIHEAYTGGALEVDVSQMERGEVKLKYRMDRPLALRKGYNSFLYHWTVISRNEYIIEKIRAVVNVSLAPTYRYNIIGCDRWRPSMFDPAKDFGSVTIRDMRNGIGETYEWLLDVSSGEEQAGIRCGPNEDLLPNNCESTGYDLSSNQIAPFPTSVRNATHYPIRGFQVFEMSFQNVPVSHACSCVDVSGYETSRLILKSNRREEYEYTVRREDANQRLLPYSLLPLIEVAYVYANITPMRSVMLHNAPQIPIKLHSGTEFIMRCVLDGGLYDDENNAGAIPIWLPYYTGFNHYKVDTTAKGDMLIPMRNEDRIAGTKGGIEIIMLEDNNQYSDFTIKSNSGAILVSRDPDHSEYVSMTFVCGKEFSESDFDQSINDVSAADIPLTLTLLEEYTWNVVQIDVEMTDPYIQGCGITDSRDTLFKPETPNIYDADGGEIGCKIDIQTAKEAAFYCPAPYVLDPPNCFDQVLVEGEVMNLSEVSYSLVASRTNHFVTLEFDGKVVGAGETLRQSPPLECRCVTIKGIVLSTIQVENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBK6</accession>
    <name>A0A061DBK6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769498.1">
        <property type="nucleotide sequence ID" value="XM_012914044.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBK6"/>
    <dbReference type="GeneID" id="24565853"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312150"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1526" mass="168852" checksum="3072AFA59BA41303" modified="2014-09-03" version="1">MAAKRTSSVTEHGVKLETLKDCLQFLEWLRDTKRSGARTQLAGRLARLLNNKYNNVDRQRIEDALFQFLNEVSKFHHKLCKKADQGTHKPQTTKPALNALLECIPKVLAVMYYLRYHVDKGFAAMGGGDWADDMIGQVEMLARVMPSGSLMKHATNIEKYLITPNGDKYGVIPGGFEPSDLKPNTGGGYSVGSAMAADLGNLLDKNRYKENLFLDVYSTTVVGNKGTDTPNIANALRLVRDFCRIFAEVEDEDDFKSHLYTKEKCINYNQLKSHCAQLKDPLEKIFKGERFSFTGYGRLFKDLNKQNVAKKMASWFRTNLDDVLSKLTLIKSISSLKGINSRSFQKGKISSVEHAKALANYFNENFFRYGFTFYGHDFNKWSNTYEVLKTDWDGVIGVMKDKSEGLEELVQILNGEVCKLQDREETQKGKEQGTEDKNEDEKDEDEESEDEEDAPLDDKDSPPVKTEATKTEAAKPTAPKVDGTPNQGTKAEGAQNQGKKAEGAQNQGKKTEGGQNQNNGYSEEKPGSSLVAQTPQPHTSSVQNPDPGSSGAPSTGGGQGQDGQAGYDVSGQPSHHVAQAGAGDTNAASDTDSVSGGGAAGRAKGAGDTRIVYPELDERLKVYKTILKEKRDRDEKNIETILNKFNENLEQIEQKKIQQQMENNLQRQLFANLRSADLHRNQNVPGYTGGRVDSGRNYYDPRGNQGRREMQPISALDGHVAVNPPPDPNFSSSSIPVSSAIGHPLPDRLRASRLNEDLVKTNEARRRIYARNEFQRRNSEFIGAPATDSRGIPKSIPRKVLDYNGIPTGNAINQPASPVETAKHATNRIPFTDVPEVISQSIPDPNRRNHLPPLPPYANREPLAATTKPNPITNLQIEDQTVAHIPDVLGAALADPLRTIPQVKIPADIRNVYPSVLQFTGVPIPYPKKDSPAPPLPNAKLPKMSAVATTTKIPHEVIPVFLGDFNPLVSEASGQHISDPNLGRRMPPLPTSKPTVQQDHTSIKSPITPALGNHDMDSLTNITISDIESTPKTVAQVSPWYAMAAGYPLNPPKTLSKSAIHLLPAPIPSMNPIRMKPTGIGMPEYKHPPLIPHAPVITDTFDDPSMDKFLSAPSISMTLPLRSDVDIPAVQHITPPTPPMPDFNGTIVPDSNLDSNIPKVYLEHPPPIRFEMEKAYKQRKTSDPFEIDIHVPKLKLPDNDLDFELDFDDDSTHIETETLRDPVYPPFPAVSFNIAPPDVEQSMPPPQDFDPEKIHRPELKMCISSWTTSTPTPDSTDIPETELLPAQAPRTVREMLTWLAGLRNEKHHGTLRQCINKAFSGLYSDPSQLALSINGSYVRPTDVFDILQLTAMFAASVLTSIAPKWRANASSKTVKPNSSTQSDEPDCCTLLCQLRDYAYAAHHQLEFLKAQCNRGKSHGGWKHHHYGSETKKPSSLQAFLTDGWDSDFETHPFDPCNLCHKSRVRMGFKHKDLFRTSQLGSVISTILTPSCGGEEHDARLDTMVIIAISSNVLPHDMLCSRDYSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM5</accession>
    <name>A0A061DBM5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767336.1">
        <property type="nucleotide sequence ID" value="XM_012911882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM5"/>
    <dbReference type="GeneID" id="24563691"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203070"/>
    <dbReference type="OMA" id="CASHVYE"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="545" mass="61601" checksum="37B000B5E73CAB79" modified="2014-09-03" version="1">MSPSAFLTRWPLRLDRLCSSIGVANKTCSQRTLGRIAFIGYSAAPGVCNHASVPNSCYYSGSSFVTRRHLSGEAPSASKSSDADDSTAENTLYATPGSAAVFSDIGRMDSLSPRQLRVLLEDAVTARVSDPNFWAKASSCAMSIASQFKFFDTIRVLECFAAARLDDRALVQELVRNLTPQVHRMEPRHYIQTIDVFGRFGRFPEQLFMEVFYGLMRDAEKLYGSEYAELFLCLSRWEIRNPQLLSSLCRALCTNISLLRYHELCQVASCARTLEVADTAFYMVLDEWQRKELQMLTIQELLDAAKRLRTQEITWAPYDEALRKEFVRQTKEVKDAACIDQLADPFDCLNFLRLTDSVSKEFLLALTKWCEDAAHRPPTRSQKRPESHDLVHLYNLVRLVSTDRVVNICSEYNVDSTYLDKAILKFVTSKGGLQLRTPKPIATQYKPNRKYVHLDDPANPGKRRPSLQLAEGDLESVEADEAQTALELKAESEHISQILDDLEPLPRGIDFKKPKKVSTQSCGKASFRLKPKTFRHKNVAATQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBP5</accession>
    <name>A0A061DBP5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ENOS INTERACTING domain containg PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0203270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767356.1">
        <property type="nucleotide sequence ID" value="XM_012911902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBP5"/>
    <dbReference type="STRING" id="5866.A0A061DBP5"/>
    <dbReference type="GeneID" id="24563711"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203270"/>
    <dbReference type="OMA" id="LENVHEH"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase-interacting protein zinc-finger" evidence="6">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="275" mass="30818" checksum="E83EEC875DC7D4F8" modified="2014-09-03" version="1">MTRHSKHNTGNAVFTYHERRKVKDFNTLRQRLGADSMRKCEHCWLCLSTAVKPVCTPAGYVFCKECILKCCAKQLEDHKREVEEWNAQLLYEEAKKAEEFHSTHESLKRKLVDTSVFGVSTVKSAKRQASGAPNEREKATTAADSNFWVANATRKGDAETKGERGARMPPKPKPGLKCPITGKPLKIKDLVEMHPDTEESDDPASGVTWVCSVSQQPISHNPVLLDRRTGRLVLRRYLKLSNAEEDGLFIELIPGGTGFAAHNGVMAQKYREALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBQ1</accession>
    <name>A0A061DBQ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">-Transmembrane and coiled-coil domains protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0404790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770179.1">
        <property type="nucleotide sequence ID" value="XM_012914725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBQ1"/>
    <dbReference type="STRING" id="5866.A0A061DBQ1"/>
    <dbReference type="GeneID" id="24566534"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404790"/>
    <dbReference type="OrthoDB" id="342726at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008559">
        <property type="entry name" value="TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917:SF0">
        <property type="entry name" value="CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917">
        <property type="entry name" value="PNAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR97993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="21971" checksum="EF30BB85DBA39F09" modified="2014-09-03" version="1">MEAVEHVPFEKRDLILVALFSIFCGILKECAAYYFVYRRADYQKKFAEVCDRYEDYHRTYVMFEPQTAHHNCFRAVSLRLLEATRDLRNLQTFYTFITSVIFMILMLMVMSYFEGCVVAKLPFEPVWPLSLFTLGDTMTTDVTNCSATCIYTMLSMAVKDGIQTLLGYRSPMTTFSEMSVKSGAEQSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC42</accession>
    <name>A0A061DC42_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0204730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767501.1">
        <property type="nucleotide sequence ID" value="XM_012912047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC42"/>
    <dbReference type="STRING" id="5866.A0A061DC42"/>
    <dbReference type="GeneID" id="24563856"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204730"/>
    <dbReference type="OMA" id="IMSATYH"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="97"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="195"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="279" mass="30793" checksum="7B79AD8A0CA1F4C5" modified="2014-09-03" version="1">MDAKDGNGGSHACNILKGTTIGGLVVSSLCVPTDVVRNYWYFNPELKGIRGSISTAGVARHIYATRGVRCFFTGFHLTALNVVGGQTIFLLSYDAMKTEMSTPLASILGRMATLLSMQPLECLRTYTQANLPGRTMSFFQHTQGFSRFTSLYRGLIPTVIRDVPFSAVHWPLNDLLYRRFIASCGRSESDLTRVQKFALSFATGTMSSILATMISQPFDIVKTTIQAAAGRKSKMTVRGELRRFFGQYGMRGFLIGLTPRLIKVVPGCAIISGCYRYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC51</accession>
    <name>A0A061DC51_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767516.1">
        <property type="nucleotide sequence ID" value="XM_012912062.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DC51"/>
    <dbReference type="GeneID" id="24563871"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204880"/>
    <dbReference type="OMA" id="KCANTIA"/>
    <dbReference type="OrthoDB" id="366110at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1784" mass="199249" checksum="03488DFFD0B9B1A6" modified="2014-09-03" version="1">MDKMANTVKYGRKTRKSIWYLTCFLVGLSALLFNVITSFESYVWMRHMGLSPLTVQGFWYFAKRIHCALSIILILLVLSNSVTKCVVMCLTWCIFVSYGLLSAYVYCNGMALKSSVMIKCLVAFCSLSSISLQSCFFFFIFNPYGGKSIYEALRCMLFFLLGSSSASLIPRIMTSCVTAFYGMRAEDVIQTLLLLKVMLYLFSAITFVSASLTAFLVHNNSESSCSEYLTLSVGKVFGLMFNSASMRRTFLCSFGWLMSPLCGIAASSFLFNVTVKEGRQIAILDNVIHLFIICVFVIYSFSRPFAAEIQEGENEGIQGNDVEQIERGTKRDETTVTSEIIDGDKDYHNPNARKPVRLFRTPQPWCLLPSGFWNVWEDEDNKDASYLTSCATIYSVLQTVNGSNMSAEGSDDANGCLITYKDVTEAKHRLLRLLSSFIASCDASSESMMHDVGKLAKENCSYNDLKSAMDRFVGQCSCIEHYSLCWKCDICVYKSDMAAEKTSVKPQASSTSAEETTERTSAANRSGGTPSHQMNPGSSHAVGAARDGTVSLSNFVSLAMNTVNCHMGRQLSNCMEKARSLASAIRQSPELSDDLDDTSILKAAENLDYFLEQFLFLLSYLHSVNEWIILCKSMDTILERCPPLVDMMIKRHDCCKQVNFVKECNANAKCGCSSIFMLAKCVQELHQVQCEIAVNILKRSSPHGSCRMPSVSHVRVLTLIVCFFDMIMSSDLAMDVGNCRCSVKEEGKNCACRFYCDTLDRLLSNWLNDVSSSMNYGDALLRETIHLLSKVIATNTLDFNEDTPNYMNALRRFVGIGRFAADFSSKIYMANYLLEEESALTAGMLAKISLDFNQLCQCDNKCHATRGEVKSESCNCFIRECNTCRKSDECAIDILGSLSSIGTPTNSGASECLTKSCESFSAITAKMEKICEAVADKLKCANTIASTVTNFVNKIGEATTSTSGMGQHPHKSQLCKVDSNNKDVARLLLYGCNIDGRSPDSHVCTDSSTVNCEKDNCKSLSCILKTFFTTVCGENADGSRTCKCKDKGSDGCCCMWKEGLCSVLCGCADELQKLLKKLGNGVADTGNESLLCRIKTLCNTVDCVRCHLTDIDSCTKELHSMYDQYHGQLSSVAAYMCNRFNVEAEHICALQKFLDENGTVYDSALKSITKVVESTSDLSKKHEDGIFKLDDQVNTLTSNMNKTCDRLQSLQNEVKVSLKGIDAEKRNFVITPTATQQFAFRRSLKVSKKACASLRNYIRYFDIAWFLCLGICYIYGRYYHSSNGGFYTTSRNYVLLLTIKGVVMFTSYALLLTTCRSYQGYMINISLLFGLLMAVFMSFVSQWWNYTLFIKEHAKPIDRWFRLLYPTSAYGTDLSPFTWDHGLSNMFRADMNYLKNIFTSNGSVIYNHDPFATLFDDYFSFSNKPISFFGLCAWTSFEKQLRNKLIDDADEDNFKGLLDYIAFKKASLVGLDFLFSGPVSNINKVPLDLLWSAWSMQEALTLERCVAYSILEIVYKDVYGELLAWMNSVVTEEGNHMLLDSFDAKERQTLAQEALWVPNVAERYVKAQQISSMNDLFRNSFLRKWSDHRAENAHMITSPGAGDSTSGVPEVESGLLFESYSLSSAVKTWRKSREEACDRLYGGSAACNNMVTSTADLIENYLSESGVGNKALSYGDLLKYVDTSRAPRIFASSANALEPVDNDSLTDVALENPIGHCQEEYATLYSQPTMLIPEHTASTQDEDLEVDNQGRYFVGFWLKHNGVALTIDDVKRLLSYISEETKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC53</accession>
    <name>A0A061DC53_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768705.1">
        <property type="nucleotide sequence ID" value="XM_012913251.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565060"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304230"/>
    <dbReference type="OrthoDB" id="367094at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1661"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1723" mass="193786" checksum="3F5F51932B5E4D83" modified="2014-09-03" version="1">MAPQFKKLTDCPENLREAIDWLIQIKNGGDGKGLENLSQALKKLIDEAIERAYTTNVSALLKALASVKSYTCCKDKVVEIEKLKNPKRLAQNIFDDLKHDCEDIKNCSKNHLDSSQQKAFDDIQSKFTQLENLQKSLNGFTDQKSCETLLTNLCSGLEKFLGFSSDSKGYTGEGIVYSDVDRLCDAVMAFLLGVLEGVKDENEVTTYDNYITPNDRKLQNVLDTLNNKIGTGRTGLVESVAAVKGWLEGYEGGVNQKNSKITMPIYELEKQIKDKISKLQEFVSKKYEDKESELAAWVNSIEELPKKSKKSYEALSHLDGNLKNKLHPHVDVINRFSESFKKTLYNDFVGLVQVCGKVDEEFNGLNEHVDNCINHPVNGLKKRIDNDIQEFQHNLSTKHPKALEESIKNAKQMLTDAKQAADEYLQKFEPQKKEQFDDKIKAIEALLDEIDKSKNTKGVSLPATESKLHGEVSALTGMISEMESQLQAGASKIGNAINVAVQGINLALRTLDEKVKEGLEKMKQQINPEVKKVISALKKGVENVANGDSEGADFRPGEHGAQDIIIEFQSKLGNDAETLYQWGRAAQNGNFKNVLAKLDKHTGSMSTNNYQAFRSFLEQLLQDLNAQEYRKSFFDALIADLKKKVDDKISEIKGSMFTAVFQRYKQETTQGIAPAVSSDEPLHSRIDKIKTTVAQFFEEGKIKGIDDKFNLGQQGPFGEYHTKMQAALSAIRKALSKITTLENIPGAVKTARQKVGEFIEEIRSRFTALNTKAEEALRYVEKAEQNLEQMLQCIYDDIKHYHRESTYYIDQFHDVFIKRSTIAQTEIKKEAFQKYVQSNTIQLTDLQQMVEKERQKIDDTITKDVSTGVKGLMGEMYFKSGRIDALTNNSEVKALSDKYMDFMKVLSDYITKDIATQLYLTKETKHKNVHYNRVDGTFKKLKEILEHLKAKKHYDHKFTRLLAELQELLAYLHPSSFAHIAMPVVAAIKGGVTGLTNQLQTAYVLVYDGEKIDWTNDEKSTQHCAKAFVTLMYTLYQQLHEVYYDGGTMWKAHRIRVKSEGDEKRLQTYFTKAGYETHHLINEKNIGWEVAILLKKGFGAHKEFNRSPNDFRTFDESVAYFTENGGLLSKLFGYLEEYNDVSHMTLRPKPRHPSSVYDALVWLTGLPHTRVRSKMLAGPIQELFENPDDKEAEGDDGLKMSLVTVGVKPVEAHPKPIVYDRVSAWLDDMCSKSYDLLICIVGPGDAATYYGCDYCNNALNLYYPADAAECFDLMCDMLGRIYSPLKFLYQQCRNSSSEFGWSDCLYGRDVALTKWHCGQHSSVEVGCQANGQPNCQSKCEPTCRPTSPLMSYLNDALPGHLPHKLSAVGCKYKCSTCSSGSRSMPCLTPLGFRAFSGSTRKGEDICSLLKEICGDDGVLTSLVSSLTCLVGGPPKTLPDIFTFYYNIIKPWMKTPANALPTNIIQNAISDKILETVGCKHDDAVKLLDSCQELCYSTSHSKHNIDNPDLKYLAGCGTPNCGAFFLTLNSTAYSTFAPKHAGNYLSWLLYSAWSLVDFIDQLKNAFCSISCYNSDCRGCLNDANCQQGKHGNKSCGCQSIVHCTGVSSVFYKCGLQFVDIQTGTRKKCFNLREALEKLLSSDLLNKFLNAIDQFLWKIREPFSYLVLTLWLLSLFYLLHIMLIRLDLLHIKSHLHSPSSHRIAAQSLLAAGRVGKLSTISYLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA0</accession>
    <name>A0A061DCA0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0205830</name>
        <name evidence="10" type="ORF">BBBOND_0205870</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767611.1">
        <property type="nucleotide sequence ID" value="XM_012912157.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767615.1">
        <property type="nucleotide sequence ID" value="XM_012912161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCA0"/>
    <dbReference type="GeneID" id="24563966"/>
    <dbReference type="GeneID" id="24563970"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205830"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205870"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="60"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="20995" checksum="59A565C61145EA1C" modified="2014-09-03" version="1">MVLSFLKVVYDDSIITTRGGLTTTDQYFEGRPGYQILAIKSNNGAILISKDPVQKQNLSMAFVCGKRLEQSDLSVVTALLYDYNGQQQIGCNIDIQTTKEAAFYCPAPYVRDPPNCFDQVSVNGELKDLSGISQSLVASHSNHFVTLKFESKRVGLGEKRRQTPPLECRCVTIKGVVLSTIQIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC8</accession>
    <name>A0A061DCC8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0402120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769908.1">
        <property type="nucleotide sequence ID" value="XM_012914454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC8"/>
    <dbReference type="GeneID" id="24566263"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402120"/>
    <dbReference type="OMA" id="INHDYYR"/>
    <dbReference type="OrthoDB" id="372949at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="6">
        <location>
            <begin position="625"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="700" mass="78432" checksum="61AF86C83A471C1D" modified="2014-09-03" version="1">MMCASVMIAGDGMEQLKGNAGGVMLSHEVQEAYHMSPMNCTSSPARTCASTPGRMLPLADYDYSNVEHWSAPSRMSIPNEPQWAYNIHPAYNFGQSNPPVDILAEYAQYHDTIAAQNRKIMEMQYQIEQMQAQYSQYQCLFSAANHPRYIELEYGDDLNKPLLPPSPIGSSPPPTPSPAAYFGYDNGYLLPHDATDGNPQSFMSYGATAPCTPSHTDSPTMSVNTTPNNVDTRCMFSTMDGAANVYYTSPEGVENCVDDSTKPVLSLCSMASVSTVDLMNEEVYRGMGAEFAGDEADNNLCVVRKRKWSIEEEYTASPPLANERKRRVSVDVSITDVMRQPQRPHFNPYEECLTPALIPSPPTWRFDNNVAPSVMGIPNVCYPFPSIPPFATEPVVNGQINHDYYRRDFYSTVWEQGYNHLFPESTVLWYPKAMASLPLSHGSTGIVSCTTGGGSIDNQNAVEIKGDAECTVVHQSPTYACQKAPSTTELLGATGSDEYNELTAQLGNDAQLCRRMNGSTEECMRPRNKKGKAHRPVVLPNNEKKREIEAAIKRMIELNKEQIEMVEALKALEVGGMMVIHKRKTQKDSAMEIRKATKCYDYLLDIPLTAEPDPELGEQQFKCLVPGVYWDKRSWIASWYEDGVRHYSSFSAKMHGFYRAKYFAIQVRMYKTQNHTNLLDEEAVEKERQNLIDCYGQFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ5</accession>
    <name>A0A061DCJ5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769998.1">
        <property type="nucleotide sequence ID" value="XM_012914544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ5"/>
    <dbReference type="GeneID" id="24566353"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403000"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="364" mass="39335" checksum="E49FC0FC18B2D46A" modified="2014-09-03" version="1">MADLTGEDKPNIVATAISIDKGEEVKEGINGTYKDSTRGSDTIEHRGTNEDEMGSQSAATRGINASQAAYQGSAFPSQAAVAPPQFIPQESVTGRAFPSQVPVSGRAFPSQAAVAPPQFIPQESVTGRAFPSQAAVAPPQFIPQEPVSDRAFLSQAAYQGSALPSQETVAGRAFLSQAAYQGSALPSQAAYQGSALSSQAAVIRDIFASEEAGRGGGKDDSRAAGSGAGKDDSEAGYKDKCRKTLRKFRKPIKKRFRFRSEYDRNSSSTSESCGSRNMEQVIIDTADYAKYITKCVKHSAENLDRMIHFAPPLKSTIQNVTKTTIRVKTWNIDQTTRLVQAVRMVQRIFRLKKTIILRVKEACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCK4</accession>
    <name>A0A061DCK4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770018.1">
        <property type="nucleotide sequence ID" value="XM_012914564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCK4"/>
    <dbReference type="GeneID" id="24566373"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403200"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9214" checksum="73E55C43A561839F" modified="2014-09-03" version="1">MGEKHPVAYTGQKYVQIWQTHLLFVNKMFANANLTATLTTATAIYRNVGIYSDEMYKVASLAITKRPSNPCWTHYLFASPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM8</accession>
    <name>A0A061DCM8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770073.1">
        <property type="nucleotide sequence ID" value="XM_012914619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM8"/>
    <dbReference type="STRING" id="5866.A0A061DCM8"/>
    <dbReference type="GeneID" id="24566428"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403750"/>
    <dbReference type="OMA" id="AYAHDKT"/>
    <dbReference type="OrthoDB" id="360533at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600799" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1015" mass="114609" checksum="C5146A3761B727B4" modified="2014-09-03" version="1">MAPFFVYASFLLGALVRSSLAFRVKHASELLGAGQKMQTPASPSFSQMGVFLEPKLIPDLDGNMVVSFLHTSPTSSAEAYDSVSLPRNSKKYDVGGIVQGVVKGDPVTVILGTTTGARFDILYEATVSAEQPEFRFQVPHGKFYLKVEGSGYRLPGVTTVERPCKGQLCPFSNADSKLDIERLRGKPGVYKYTWTLQNAAQYGVESLTQIDHNEASVYNAEKPGIESNIDYSDAAAKLKLNYGIELHGSWGSEYANRLLGIVDGWEFYKQLYNSNQRVQKWVLTDEPLYPQDVSITNFAKTSHDSPLHGAPMDLPREENSKYTQIVTLSKLAFTYAVRRTVDGDNRRRTYFSRRLHKAVIRALCLHNPDIMRALFYHMHDINLIEPQYIHPRMINGRPLTKFPYTDYQSWFKHPEELVEIATTWSEYPPGFQKIKGLKYLLRRQDGTVNPDEPTAPAVAYPRGPDTDSYIEFMESGFHNYPDIPSLIIHELGHFVHSNVVPADLFAKWQEIGGWFKDPNDPDGWSTRQQTEFVNAYGHKKNPSEDFATCIADYVLNPNKIKSRAPRKFEFMRNNVMNGSHYVTKASHEFTVLNLGNPDYMYPGRIIRIDVKVVGKVNDDKRAEFRFQLANNGEKSCATNGMFRLTSSAKTFVDVPMVADGARCSHVLKGRITINKTQKRGVWTTDQIIVADENRLERYVGAADFGLRVWVDNGAEDFQPPRALIPTIALSLVEGRENAIMRATWMVADDGILREKASAYAAISNEKFGQHSLSSFNQGLDLTTGAKDDWRTDRWVGSRKVPSQMCAAEYVRKRETSPAPYFNQYAFEGEDRFDGLSQREIAPGLFNCFEVSVNVPLSPAARSGDYHLSSIISFDSAGNSQMLQWPKSQGPYVTYRNRLTQEDNSKPEVRNICVDSEPTNKHTPNGETKVDIFFEIRDVHSGIAGLKASLRDPFGAGYTVYPKFEDQKDWQKIHYQYMLPRGSIPGVWHLSEISVQDHAGNELRAELHERVIVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCX1</accession>
    <name>A0A061DCX1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0308530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769135.1">
        <property type="nucleotide sequence ID" value="XM_012913681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCX1"/>
    <dbReference type="STRING" id="5866.A0A061DCX1"/>
    <dbReference type="GeneID" id="24565490"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308530"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="297" mass="33199" checksum="D4CC58EE70A66244" modified="2014-09-03" version="1">MLRGSRFSRDSGDLKTPFLAGKERELLESKKWPACFSKSVDITKVQIDAFKPWITRRVTELMGVEDEIVVDYCLSQLKFFGETDAKANAENAGDGGRCLNEKPYLDPKKLQINLTGFMAKNARIFVKELWDLLLAAQDSEYGIPQVFIDEKKREIAAIQGAANEVEDTLRQMGSSLPASNHTERDSNSAAEGAVQNTNEPSSAVGVGGEAESGPSEHRESHRQSLQSKRSAGRSWYETRKRANRRAKYPARRHDDSIRDRGHRRRHLATAVVGHTPACLVIPPVPQSFPWTLVLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCZ3</accession>
    <name>A0A061DCZ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0209830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768016.1">
        <property type="nucleotide sequence ID" value="XM_012912562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCZ3"/>
    <dbReference type="STRING" id="5866.A0A061DCZ3"/>
    <dbReference type="GeneID" id="24564371"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209830"/>
    <dbReference type="OMA" id="GSWHVDY"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="262" mass="30913" checksum="094540E7E50DABDB" modified="2014-09-03" version="1">MSVTGPSANITAIERLSELELQQGIIGPSSWHHQYKDSCYIYIGGLDKRMTEGDIVIVFSQFGEPIDVHLKRDRKTGASLGYCFLGYKDQRSTILAVDNFNGCTLLGRRIRVDHVLDYKAPVEYEDEEDDEGNKIRKEYTPTGAEGQGIGKYYVTSSEAVLREAHHHRPKPQSNPQDNLDEDERWAQEFEASLRKDSTPDDDAKKHDRRSSSRSRHRHRERSRERHRKREDRERRRSRSRDRSRHEHRSDRRDRHRDSRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCZ4</accession>
    <name>A0A061DCZ4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-BINDING CASSETTE TRANSPORTER, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0308920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769175.1">
        <property type="nucleotide sequence ID" value="XM_012913721.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCZ4"/>
    <dbReference type="GeneID" id="24565530"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308920"/>
    <dbReference type="OMA" id="RLEIYMC"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="899"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="984"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1078"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="499"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="845"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1236"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1533" mass="171563" checksum="FA627731CBD4A7AB" modified="2014-09-03" version="1">MEDGATGGFGPEPYEYSPNDAMPDSAYYDKAGFFNRLFFYWVRYWVNNVRNDSFDSERLHPLLNGDQIGAWQSLFAKNISDGILRAEQKRHDAVLANGECDKNKLYRNIILRALLLTFGRRVALLLLATVILNVGGVGISMLLKVMLDKMSSTSGAYGMIIRYAFYIAIIELASSLFEQHVIFYNCRLETIMESAISITLFQHGMCHRRAYAVTTDGQSQLSACRGVVHSWPCKNDECASNPLFCPARRYQNKEMAPSMCTYVFLDTYALMSPLEALVIGVRFLTTLITALIIIRTQISTDVAKTIIILVSMILLTGVIEVVNGHVYLHSMQSKDYRYSKTYDVLGNINLVQTMGLDDIGYKIIEDSRNDEVSVLFTRLTLTAFNRSTMMTIGCIVFLVILLDYIETLETSLGNQPFEAGIPITLMFIVGKITKATENLPKTVKVVAEAWASIIRVEKFLTTCSPNYYLTCKNKPQPMDYAMTSVASQDGTSLEQDVVVKYEGASFAWFHTIEDSMEEVPIKPPILNDLNFELKRGDVKIITGNQGCGKTSFIKSILGDMSLVSGSMAVAPLSAGMPIFYTSQEVWLPSGSIRSIITFGYAFDEDIYRQVTCAVELESDFASWEDGDMRVISEKGYSLSGGQRVRLSLARALYAYLIFSKANERLVGDRCCFLVCLDEPFNGLDTKVASSIARNLLNTVDGLLIRDDVAVVLAISKMSMDICFNNSNLDDLVKIPVYRLGSKGLRMWDSVGSQDLREISAPSMGDVANSDPGSLRTYRSLTSMPPAVMRTNVYSASASSFSNPSFQSQSPTASKEDIEKEKELNSGSTYKAYRVYFYCTGYVTCVLILLMVVSGIALEKANSIFVASWSDSIKNSSDAGIMTIDEGRELLKKHEHTVNLIKGFSVSYVVLIYCGTILTAIASMRCAKKLHQYAVNSLFFKGTDELSLKKSFGDIITLLSTDLFYIDEILGRTCLLSVISFMRLAIQFVTMCAAAPIIIPLPIIMVVYLCTQVVGAHITSSNRLQCFMFKAIARINATFTDVIGGAAIYRGFRMEFQCLEYLYESSEYYFRTRFLKKVFPAWLIIVSKMLTSCIIFVATLLILAYAHYTGKSVQIATLGLIITLAMEVNSLITSFVYNHSLTERMMCSVSRFEKHLLQGKSSLNEKFESMNETVLRKVGDEDEWNKESYAALLKRRKSEFRNFVFRRYRSVLSTLFYKPRVEFLDCGEYLCGEHVSLELENVSVPQQVSATGENRRYILKRITASASAGDVVGIVGRTGAGKSTLLSVLQNIAPGREGSVLLDGRELNSIPRKVLRHIIGVLPQMPFVFKGWTLRRFLDPRMLHSDNEIMRAIECCGLLDMVRSLPEIDPLDAVMVDQNVDPGRGFYLVIPIIKLKSPSEQLPVLRRKSFESSKSDENSSEVFSDSQLRMLSFARLLLYRRTYRLLLIDEPPSDNCASGEDDAAIVHAVSTIDSSIRVYDLVRMYFKHCTTFIVAHDKNALKSCQHLWYIDNGAIVRKVSGANSVAEFLNSTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD34</accession>
    <name>A0A061DD34_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769250.1">
        <property type="nucleotide sequence ID" value="XM_012913796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565605"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309670"/>
    <dbReference type="OrthoDB" id="10561094at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1607"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1669" mass="187597" checksum="DFAB99255412CD43" modified="2014-09-03" version="1">MVPKKLTDCPENLRESIDWLIQVRHGSGTDKNGLDGLAKSLKTLIAEAITKSTKSLEAEHDKLVCPFQYSATETNCQHYQTLLENRKKEIKDAEPLRDVSKDAEVKRLMGTIADCRNKYHNEHYRDPAKQKILRDIEDRQKTLGNLQTKLEAFVGKVANKEQKDIPAKHILENLTDGLEKLLGFDPKSKGYDGTGIVYSDLDRLCDGVMAFLYGLLRDVYQNQSYDVGRRVLKQLVENKIHPKLCLGHSGFKEIIDEVARQVKLYNREVEHSNKKVSDPIRGLQKEMTTLTEQVKIILKNSVSQDFVNTAVTEVNKQLDACNKNTDTFNRNMDSVERIHKAITYLNESIREKVNKARTNIRHEKKRLEKMTKIERSNLSSMTNNITTTLEDVKTQISNNISEIVKQLVEDLKKKVQEIQSELVEVYKSLGKYIKTLEDWMEKALEVIEEANRQVAVIENEVGDPEDKKNNNKSAIAKAAKEVEKQAGELHGKFETAKRQFDVVVAKIKGKAGDGQEEGCVIEKLQGLEEKVTTTMPEDFENFNTGNGGNWDFSQSIRELRQETNRQLGIAIDGIWKDLKQGLDAATESAPRSGNWKGLQALQETDLWTAKGVGKWLDSAALDYDDSGPGAKVEKVLNHLHNAQQEWENILQSNITTNIPKVIKETLSNETIDGVKRQLLGLIIAVVAGSISEMQEAVNRIVDTDLNTISQLQDSIAQQAQAAKAALETQGNLVYHHLTELCEAIKNGVKYSKQHLGTLANDTINTQLKKIRDRFTELQKRFADGALKLSEEFAGEADTLCTSTVQQLQKQVDEQISFAIAKLTSQAQKNYVSSMKGLLDAFATKVQGELLNLPERIDIDLKTEFKGFMKEMETHVSSANLKNDLPQHAKLATFASGVGNFFNGIFHSLKTKRDIIPIHKLTEIDATLNTLLNGLSNYNKKFVDDLAAVNTLLQSIRPESYNDERNKLLEILKNGLQGFHNELKNAYVSAYDSVPNVDWSDIKSTETSLQGTKCATVFLTTIDIMLKSLFKYKREVEKTKSTWKDYKMYSSNYNYSLSSLFFSKNGYDPGLPSNAEYGELNHKKGFNGNSIVDLFKSNTQVTSQPSYDILASLDDFADIIKYYLRISHLGTFSSAKHPLNAFQMLAWLSGLQHNPVKEKLTKYLQKQFDSETDVILRNILSDIFTSELPSIYTPAYDMLTSIVGYGDADTLYACQYLGNSLELHYPSDAAACFDMLLDVLRKLCPVLQFLYWQCKLGVKNLGWRDCHYGKNAGTSSWQCKEHSDQTPDCQRTSPLMSYLTDCLLGHLPHQLQSVGCTSKCSTCSSSSPKMPCLTPLGFRTFSCSTRTGKDLCSVLDKLCGDRGVLTKLYASLACFVGRPPQTFPDVFAFYYQLVQPWTPMTEYKKPSNSIEQALSNTIEKTVSCKYEDAKQFINQCRSLYESPSHFLHDITRISDMSYLVGCGEQDCGYIIRPINSAAYGAFAPKHAKSYLSWLVHVCPQLVDFFKQLQKAFSDVSCADSRCSPCLHSESCTKGKHGTTSCGCSSIVHCQPVSSILYKYGLTYADAANKSQIKCQDFSNVLKNILNSQVLGNFLHAIDTLMFTIRTPFIWTVVALWSLSLLYLFYVLIGRLDTLHIKSHLRSPASYKIAAQSLLAAARVGKLAKISYLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD54</accession>
    <name>A0A061DD54_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769300.1">
        <property type="nucleotide sequence ID" value="XM_012913846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD54"/>
    <dbReference type="GeneID" id="24565655"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310170"/>
    <dbReference type="OMA" id="WDEKPDI"/>
    <dbReference type="OrthoDB" id="365642at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="295" mass="33467" checksum="BDE464C460622FA2" modified="2014-09-03" version="1">MESGRRTSSISSNIYRSQDGRTRTSSSMNDEVHISLGSSSSKYVNRDSHRDQNQGRSSTRDDGRDRGSDRTNSATRSDEKGEPTIKKKPEPTAAVTPDNEDLIAGLALQRLCDEKPDLDTLANSLMQLYDHLEFSTGDPDSRAELVDRIALTALRVKVKMESHINRANWRMRAAMQYSRHLEAKRRCIQKNVSAQRHIRALIIVQVPRIENNFMGMCRDQHRSKGVSEIYDRLYKVLGKIPEVSQLEVREQRLKAKHATILSNIDNMRRQIIAQRSQLETICQLMADVAAMGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF7</accession>
    <name>A0A061DDF7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769540.1">
        <property type="nucleotide sequence ID" value="XM_012914086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDF7"/>
    <dbReference type="GeneID" id="24565895"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312570"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="10802" checksum="9B69A2D45841F26F" modified="2014-09-03" version="1">MNNEIRSVVERVMTSFGLDELIRLDLAYDILISPSHRSLIEGSTTCGGSSGKAISVTTFYDCITSGCFSRKLNIGEQLGGLTSPPAWIRISSCLGIGDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK7</accession>
    <name>A0A061DDK7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0400050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769695.1">
        <property type="nucleotide sequence ID" value="XM_012914241.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDK7"/>
    <dbReference type="GeneID" id="24566050"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400050"/>
    <dbReference type="OMA" id="RNCTIDW"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596246" description="Ribosome binding protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1962"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="954"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2031" mass="216535" checksum="C608825D101CA45A" modified="2014-09-03" version="1">MAARKGGIILTSLSDCLIFLHWLNTEGKGKDMQSHVASRLREKLAKYYNNLDQSKIASSLSTFLGHVDTFYKKLVYDYVPEQQFLSGASMSRDAEIRDADILVKALLECIPKFLSAIYYLRYCVAYTFVPLGGGGWKENWPGYEVAWWKHFGYDYGGDLNKYLFSNKSHEYGGILPGGFTRREIKYGHNWGGYSRGYSMVTDLKAIFGKHDDQFFRDVFATSVLSESSGADKPNTANALALVNRFCEIVTDEAKKNNGGALKEKLEESIKGSRNCTIDWESLKRHCEHLQEQFGRIFKNEGFAFTGYGRGIGELKKQDFAKATAQWLRHNMEQVIKNMTGIKPFSNAYDLFDMTRYTNGASKLMEYYADLGPHFTYNLFPYGFTFESISFGQMAAPYEGLKHDWESVIKTLTGSDENGGLKKLKTILDGEKCTPAPPPKPRPRPAPAPRPPRPARPAPPPKPTTGNSSGAQGFRGAGGNRNSGNGGQMESGARRVKGSGGAGYRRGSGAQRSATQVKSVAQSRTASRLSHVQASSAQKAAQPQNADNSSSQQVAGPQQLVEIKAPPAPSVSVSRNHATSSTTTVQEPDIPSVSPQEKPGHIASSHTPATPGRSGTSGDSNDQARSSNPFVQPGVSVSSSVSNPPNGQTLPTDRVVSSAAAIHPTTHRAASDGGDGIGGNGTAGEMGSTGGSDSTGSSTSLPHPPPPAQLEPLPASHDVTAVPELPKEVVPEKKVPVIRVPEPITPKIAEGTNKLEGTPIHGGKLGVNPMQDNNQNTEKSPSPVVVTSVQVVSPGSDHQNPQGSEADQSPHAVGGNDSVASSDSSVQDPVLTQQHVTQSTYMSQSPSSPSSAATPEVTGTQGDLGADISAVVQPALQTVAPPDAVDTPTLTVEPQVQPAHSPTASSRSSAAPAPPVPLGDPGGSSQGDASSGRQPAVSTDTLVTQSPSVTDSVFQPSSVLAPSGSSSPDSNQGSSQHGQQNGLSSTTTSDTGTTMKLPGQGVDPGSGEAAGSTDGKPQDSLNSQLPTQLHNPSDALSTSTSSVGDSSPLSPALTLQSSPQGNSNDQSAGTSDESTTTVSQYDASDPAGGADAAGKQAQQSVDNNDNASQGQPGPTLSVPTPPPPSAPEPTTADTPSDSDTGSKNNSTLTQEPALPQGSGVQPPGSSSSEISDTDSDPVAPGSNGDQGSPGAGTLQPSPQPGHSDPQGVKQEPTQATSSPDSATSPTTIPAPSSQPGKADGGDQGLQDNSSRAQSDVISQAAAISQHSGVSGSVPSPTGSLGSDPIQLPNAQLVSKDNQQSAQGSQQGSSATKMPATTVQSSDSDGSVPGGVGTSSIVQPPDPNIEISFEVGKFDDTLSDANSNALQDQATNKAPNVIFDIIKPTFANYGEDSPATPSLTPPVGLHRDYDAINDVSDETKETRSNTEDSVDLFIDVLKHPPSQPLAEYDPEYIHAAPKLGRPKVDDLDDLALKDAEGAKMYTPLAVFPGQSPFDDNPNVCQAPWYVPEHSKNLIPPIVTPPPVTDHLHSPKTVREMLYWLVGVVELGYIGFIRKHVDVVLDDVNTDSFLPTNVLLVTRNLTTVTSHEISQTLTAACHYAAKVLHRLKHRDVSNETSIPEFNAEYRNYYYSSDPDGLLCQLRDYVYAAHHQLMFLRSQCGRDKFRGGWKSYEYSSGIKEQSPLQAFLTDSWDSTFHTHFFDPCNICLKSRIKMGFKDKDLPNISQKGSVISSILSATCSVDEDPLLTLCSYLNCLSRRTPRTTAELISFFDHFGSELLSGSDQTLTDLGKAITEPPALYPNWDHFEAHDLRAVRDIRRPESPVSKHDNDHAGTLSTLLGCDSVTSNGPKLLSPITYRAYALYSPAFAQTYLSWTVYLADVLRDSLDRLRYDFKTHTCSGNKSFNQCDMAMPLLYLHGLTPSEGISQSSLTCSQVITKLEEVVNGGPIGKLITCMDEFLYRVRGPFIYLVIALWSAAFLIFAKTMIYRLDVLHIRSHLIRSTASHRIDVKALLTKGRKMLSLYGVDYFDDDPMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE87</accession>
    <name>A0A061DE87_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769111.1">
        <property type="nucleotide sequence ID" value="XM_012913657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE87"/>
    <dbReference type="GeneID" id="24565466"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308290"/>
    <dbReference type="OrthoDB" id="364465at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="220" mass="24404" checksum="E087F871D177FCAE" modified="2014-09-03" version="1">MTHKRGQILCTSDPCIPESVYCDETFGRVSRKRHCNVRSPYEVAATGRRDSPNRPIESPGAATPVLPDVEGSTSLQELASEWSDRIVEGLRRMQNTHDLKEPLANYLTQFYHAAVSRGCEPTSQPEHPQGDQGEELANRIGQLLHRNNVLCNVIRNQYETIRRLQANEALASSLMKEKAALREELLGLKECLNAYVGSVGAGASCGPCDAQFTRRPPDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE98</accession>
    <name>A0A061DE98_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0308580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769141.1">
        <property type="nucleotide sequence ID" value="XM_012913687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE98"/>
    <dbReference type="STRING" id="5866.A0A061DE98"/>
    <dbReference type="GeneID" id="24565496"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308580"/>
    <dbReference type="OMA" id="HHIPATH"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="344" mass="38844" checksum="0599F93EFCD3EE66" modified="2014-09-03" version="1">MSTLLKYRLHDATGDGGRCLNEKPYLDPKKLQINLTGFMAKNARIFVKELWDLLLAAQDSEYGIPQVFIDEKKREIAAIQGAANEVEDTLRQMGSSLPASNHTERDSNSAAEGAVQNTNEPSSAVGVGGEAESGPSEHRESHRQSLQSKRSAGRSWYETRKRANRRAKYPARRHDDSIRDRGHRRRRSPSSGSSRSSSESVSYRRRTHRRRSPSRSSSVSYSNRSGSSSSRSSSAVRRAPRHGRRRPYSSVSSDSPSPSEFSLDSRASRSVDSSVSRRSRGKRYESRRSRDRSVSHRRRRSSDSSSSRSSSRSSRSSSSSSSYRTRRRRGSGRRYRSRDRRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DED1</accession>
    <name>A0A061DED1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LisH domain/WD40 REPEAT PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0309610</name>
        <name evidence="6" type="ORF">BBBOND_0309730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769244.1">
        <property type="nucleotide sequence ID" value="XM_012913790.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769256.1">
        <property type="nucleotide sequence ID" value="XM_012913802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DED1"/>
    <dbReference type="STRING" id="5866.A0A061DED1"/>
    <dbReference type="GeneID" id="24565599"/>
    <dbReference type="GeneID" id="24565611"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309610"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309730"/>
    <dbReference type="OMA" id="NEASICK"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="559" mass="61275" checksum="C5AF1AABE32E5EDE" modified="2014-09-03" version="1">MKINLSSDDINLLVYRYLIENGYSHTAFSFSKEAEIQRNPYYNNHADKLPPNALVSFMQKAMIYIYLEYHTDDLTGEQIVCEEPFSFFRKHACFRKLGQQNGLPIKETMLLAAEQNELAREISYGVCKMQNDGIPDTCTDCIFSHINADMANDRGESQDGSALAQIPPIYVGPPQRRLADRWQVSGYMCLMDYGPLGAAASAQFNPAVPGYIAKRVEGAPPALYDISKVGKIKTCEIVPTVAKLTETDGGPAGVGTCLRWRYDGHALCTGYETGAVVIWDKKGRRMCGGRLGRAPITAVAFSGNRRFWNDTDDVNTVCKLAAGDAAGNIQVFKIENGIHHVTVYNQGAVVTEIDWRDHDVFAAASADATVRIYNTATNASAILQDAVQSNPQFMEWGPTGKCLAMLDSTETLKIYKPDGHGLQGGVTSLRAHTKSIIAASWQYGHHAKSANKICTVAMDKQLLVWDVATETVVSSILIDQVPTTITVNTSDTFVAVGTYGNLIKVFNLPSLTLSCSFCDQNLPTSITWAADDEHIAYNVYNQQRTPVLPVTTSASFVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN3</accession>
    <name>A0A061DEN3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769766.1">
        <property type="nucleotide sequence ID" value="XM_012914312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEN3"/>
    <dbReference type="GeneID" id="24566121"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400720"/>
    <dbReference type="OMA" id="YGCGTRP"/>
    <dbReference type="OrthoDB" id="361345at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596276" description="6-Cys domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="94998" checksum="033DFBB3C0C67D38" modified="2014-09-03" version="1">MLALFSSSPAKCFSIAIFANLLLLRSVSGVDDTDVIKWVGDHSPASWFAYGDSNLGKHHLYFDVDLYRGEHVQVHCPAYSDYHTVLKPLDENMFYNTDAFHHKLNAIDEGGHYHYLSRWKINISEAFDCLTVKELPNEKWTISYLGKPTYLTMETLYFDCIATSDSGTLHTATVKLNIMPEYYLENETEEHIDFNTKAFSPDDTPFTYFKFPRSGSTLHLKCETKGTWSAALKDPYISGTQTMITKETYVINFDEQYFIGWLTDVSFLYCDQLGLGHFVMITQSNGKVLGVFWSHTMESSQPGMLKANFDVKKHLLLNFYCGSHCDKMYPKKIPQEFLVDGSSKLRHDQLLGNLGVIRRSPKSMTLDFSRYYSYSYYEAAWYSNETLSAAHSVIFSLNPACDFSNANSLDMDSKTCSVFLTTGKDVIIRGAKSTLGKLHMLPDSYSLFYWRKVQNPEAAWNEHTFERVTVTRRGVATSQDDHILKNASVVTFTVGTFDSPLYYIWSHNMDDDGKEADKILKVYFAHSSYLVKPDMNLPTNARGNIRGNTPYNSKVYHIVNRGAKGLKFSCSYFFESDYDAEYVLHPQGKNLIYSDVGTTHADLTEIPTVQFHEEFAVAGVSMYKVPESIDNYDFEMKFEPDKIIMAVYKQPLFFICARKDFDKSKHSYLVIGIDPFYQQERIYGCGTRPEFFLNKDGQTNSEHHCEFTLDDDKTVGFFCPMPIPSHFLEGDQKQWAPASDDPIATTNPYKNMVQCYDRTTYLQRLVGFKVDIGMFASPRDVGEVRSLWIFNNGQFIKNGKVAISKVICYCFNTEGRSVASIAVSSHFKKLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN5</accession>
    <name>A0A061DEN5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769776.1">
        <property type="nucleotide sequence ID" value="XM_012914322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEN5"/>
    <dbReference type="GeneID" id="24566131"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400820"/>
    <dbReference type="OMA" id="FYFTEAC"/>
    <dbReference type="OrthoDB" id="365789at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="709" mass="81676" checksum="858479027ADF8592" modified="2014-09-03" version="1">MDKALADLSILWGKVGPFHDLSRILGPGASDPAAAYGKTWFAADSGSTHPLQATETEMDTVYERLMEDEMLQRASKLYQRWDTILFDADRQLDELSALQEKCVRSLNDLEMRRATYCLNFKNVNHKFNEMYNRKVALSDKLATLDEMYNHYANYKTFLRTVDQIENNQFFKTLGSMRVRNIKSAKTASGSKASDDNQAAAVIESTVSEEDALDMTLEYVEKVAERCNAMLPAIEASIDFFSIHVNYFDAEALKYRYEILRTRVCELMKLVFKEVYNFASESCKGFDHFDVAAHYNKYRRIGRSVRALSDYYAKQTTELGNSEFLQLQMYYITSRIKILNPLMLLKMDSFENFDSIAAFFLLICNLEVLTFKETFVTDEAHESLGTMVDNVVFYFTEACKRQMPKLQTSTDLRSAMASIQDKLITPVKTSGTKGVLQPLMLRAQQTYNNMESTLIKSVQREIATHVRAYDKKAFVKALCDEEQFEPDWEHELLSQLKDKNLRGANLYPPVCFAAGIVLKNVNYIGGYRLNKLASEALDAMKASIVDAQYLFGKMCQLDKALVRINQDFFMMRHLQHVFVLMDEFYGIDSLSSIYGLYDTAERQFCAGVAGLLLGDFQSFTRKQRKHDQPVYEEMLAAAMTQLTDKLPILKRRMEHQLGQKYFKRAFRKLKHSLEDVLTEYSKKFSFQPPTLPEEKESGEAEEPYHRLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEQ4</accession>
    <name>A0A061DEQ4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0401760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[lipoyl-carrier protein] + (R)-lipoate + ATP = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769871.1">
        <property type="nucleotide sequence ID" value="XM_012914417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEQ4"/>
    <dbReference type="STRING" id="5866.A0A061DEQ4"/>
    <dbReference type="GeneID" id="24566226"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401760"/>
    <dbReference type="OMA" id="RYQNWDW"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="9">
        <location>
            <begin position="55"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="386" mass="43092" checksum="CA3E86FB3DB112F5" modified="2014-09-03" version="1">MAAMSIFKRCFGCGSRNPATRLRVLLSDETDIYFNLAIENALLSSYGSNAAKDGASEAPLLFLWRNSPCVIVGRNQNVWSECNLDNVKRDNVKLVRRFTGGGAVYQDLGNTCFTFISPSADYNFEKNSQLICAAMSKLTGKLCEPSGRNDLCVDGLKFSGAAFKVLPNAALHHGTLLININQGSLDKYLTPDKSKLEKHNVQSVKARVTNLSQYNSSISHHSVCEAIIAEVSAHYRSRTREIERLTTASEYCKQNAFLECYNKLTDSQWTYGDRVLDYKSLKHRFDFGSLEFCFDLSGDIVANIWIFSDTLNADFITWLHEKLNHIPLRFTPDDFDRALRGLAYECGNEMIAAIREWLVSELRRAETAAAAAEDDTVNAAQSGPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEZ0</accession>
    <name>A0A061DEZ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0405990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770301.1">
        <property type="nucleotide sequence ID" value="XM_012914847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEZ0"/>
    <dbReference type="STRING" id="5866.A0A061DEZ0"/>
    <dbReference type="GeneID" id="24566656"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405990"/>
    <dbReference type="OMA" id="IFIECVA"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR98115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="336" mass="36827" checksum="5A37318673632431" modified="2014-09-03" version="1">MVGLHKVAVAAIVLVETIVFCYAPKITERFSIYRNNWINEKTLNNATSGALLSLAFTHLLPEGFGHAGCDLVVKHVDFRGFIMGMPILLLVTIDFFAGHHCGTHSVVQSGVKSLNNSSIPNLDVDVELMHLSHTHKALSHVSTDHDYKNEGHWGHVESISLRLKQLFTSRALYLLLTFYAHSVLEGALLGAQKTAGSLWGMAFGICAHKWAECLVLNTTATNLITWGALRHACSIAFALCIPLGILIGSQIEGKSETTQVVFQLLAIGFFLYLSFELLTHQVSEDESHMRWPLWTSYFLGAVVMAAILVVVEMVEHGEGNGHGDQESHGCPANGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H2D7F7</accession>
    <name>H2D7F7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Apical membrane antigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AMA-1</name>
        <name evidence="12" type="ORF">BBBOND_0109200</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>Babesia bigemina Apical Membrane Antigen 1 (AMA-1) surface exposed, immunogenic B cell epitopes are conserved among isolates.</title>
            <authorList>
                <person name="Mosqueda J."/>
                <person name="Camacho-Nuez M."/>
                <person name="Falcon A."/>
                <person name="Ramos J."/>
                <person name="Agnone A."/>
                <person name="Torina A."/>
                <person name="Wilkowsky S."/>
                <person name="Araujo F."/>
                <person name="Ica A."/>
                <person name="Vallejo E."/>
                <person name="Canto G."/>
                <person name="Aguilar-Tipacamu G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">SP3</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apicomplexan parasites AMA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JN572795">
        <property type="protein sequence ID" value="AET36926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766808.1">
        <property type="nucleotide sequence ID" value="XM_012911354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2D7F7"/>
    <dbReference type="STRING" id="5866.H2D7F7"/>
    <dbReference type="GeneID" id="24563163"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109200"/>
    <dbReference type="OMA" id="DAINYPC"/>
    <dbReference type="OrthoDB" id="345315at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003298">
        <property type="entry name" value="Apmem_Ag1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02430">
        <property type="entry name" value="AMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01361">
        <property type="entry name" value="MEROZOITESA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00815">
        <property type="entry name" value="AMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007665491" evidence="10">
        <location>
            <begin position="31"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AET36926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="595" mass="65800" checksum="5E4CD69932B5204E" modified="2012-03-21" version="1" fragment="single">MQCILNRITLLATPVIFFLWLSTEISPAGCAFVTFQNEPTSTRGTRRSSRSSRNQQATSSTSQAGAGEATERTGGRAAGSKLIPQTPWTRYMIKYDIARCHGSGIFVDIGGYEAVGNKYYRMPTGKCPVMGKVINLASGADFLEPISADNPRYRGLAFPETVIKHTGASAGALTNAGSIHGNLSPVSAADLRKWGYKGNAVTNCAEYASNIVPGSDQRTKYRYPFVYDGKEEMCYILYSPMQYNQGTRYCDEDGSAKEGPSSLLCMKPYKSEADAHLYYGSARIDPKWDQNCPMKPIKDAIFGTWVSGACVALESAFEEYVDSAEECAAILFENSAADVDIDIDSERYNEISELYNGLKNLHLQQIAFSLFAPMAKSAASATLSKGVGMNWANYESATGVCRILNTTPTCLIINAGSLAMTALGSPLESDAINYPCHIDTLGYVEPRKRDSREDGDRNSGITTALNMQTLKCTKYVHSKYSESCGTYYYCSEEKSGYLSRLYQFMCSHNVKKAAVISTALVLLCLAIYWIYQRLWSTKKGRQHDDYDRLMSKYEYDDVSHDNIEPEHQLRTDAYIWGEAAARPSDITPVHLTKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYT2</accession>
    <name>A0A061CYT2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">50S ribosomal protein L25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765962.1">
        <property type="nucleotide sequence ID" value="XM_012910508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYT2"/>
    <dbReference type="GeneID" id="24562317"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101050"/>
    <dbReference type="OMA" id="NIPCSIV"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_uL5_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33284">
        <property type="entry name" value="RIBOSOMAL PROTEIN L25/GLN-TRNA SYNTHETASE, ANTI-CODON-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33284:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L25_GLN-TRNA SYNTHETASE, ANTI-CODON-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="263" mass="30189" checksum="1039C65033139F76" modified="2014-09-03" version="1">MSFKNILKREHWKILKRQLCEQFREHSRDTEATVAAHTWPRFVQKEHLLASKLVPAIITAHGPPRKICIKVSDIFRLAFDEEHGHLSHLFSGRLYNLQIGDAVERCVVTHVHADPIEKVLYFVKFSRHVEGCISEVDIPCTVVGLLASPAYLKGYHVQLMMPTIKCEVAGKTVPPPFLIDVSKLDFREPFNSIMLKDIAHLLPEDESVLFHRSYNPDTQEVVCTYQAGSLPEEPLPPDYVDPNFLNKKGRRIHLTYKGFFPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ54</accession>
    <name>A0A061CZ54_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765909.1">
        <property type="nucleotide sequence ID" value="XM_012910455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ54"/>
    <dbReference type="GeneID" id="24562264"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100520"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="83" mass="9718" checksum="71002F870EB19BA9" modified="2014-09-03" version="1">MLRGVNINGLAIETSQCALLATPLMQEEQARGTCTLRHQYWLLVRRKVTICAQSAHNTRQYPKYRYQDKYLRRHDASELLNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZL7</accession>
    <name>A0A061CZL7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766252.1">
        <property type="nucleotide sequence ID" value="XM_012910798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZL7"/>
    <dbReference type="GeneID" id="24562607"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103800"/>
    <dbReference type="OMA" id="WISRMQY"/>
    <dbReference type="OrthoDB" id="363947at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="697" mass="76238" checksum="181B55E083D729D2" modified="2014-09-03" version="1">MECAVHAVIQEPSGSADAFVQLHDGRRRQLGVPPQLQSRLCASRGFHAVTRLCGPIGRLLGELHALVESYYFAAERPALVSMHTCARRIASSLGIIIVYAYRVCRATSSALARYAIATISEDRRRELGSKAMVFKYGFFAHGMAVGAPNASQELLIAAALDRGSINISFNHVAHRALLQLTRIDGCGPDAAVTSHALGFDDRLSDGAEFVTCVSADPMPGLGVTLMVGYSTGVVEIWKESVCMADLREALCEAVAQCKLPSYPFFCSFSPCGEIAVVLTVDDMYLMEWTGSSLSAIKLVDGSSADFWSATGARVLAAEWLNAHEIMSLSDNGQLWLSRRSEMGYWQRITQYILADSTPRDAGLTSWISRMQYDGRGLMFLKMHGSHQVLQLRWDKTAMPDLSVVEFPVREAGGRLGPRVPSATSDPADATIAADGRDPRSSANNVEVADFALEPQSSLIAIIVSDRSAVNVYSYPKMRCIHTLEPPRPHLKAAGIKFMATGSSSVEVFLAVKWVEISLEIFQEPEDFDIDHKVASTRGAQSGRMTVVYALSSSALRSQNWQGQTLAEILSGGDNMVTAHARPPRAISFRRNDGYGGETIPRLSVFRPTFPEDVLVGTKNSVMYEDAFSHRRQVFGRQYADGDGRALPFDKKTHAMAMRDSPLLAGPAFSKATLSRSPETDTHVYSMEEFTRRKRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D010</accession>
    <name>A0A061D010_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766367.1">
        <property type="nucleotide sequence ID" value="XM_012910913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D010"/>
    <dbReference type="GeneID" id="24562722"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104900"/>
    <dbReference type="OMA" id="NDKIQCT"/>
    <dbReference type="OrthoDB" id="360985at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="326" mass="37290" checksum="31C28D52BCEDE12A" modified="2014-09-03" version="1">MERTESEDSSSTLYKVMVNRKIVEKVQMNMNTSAAPSLIAHSGAACSNRAPADCDESHEIERLRKENQLLEQKYQDTFEALDKVRQTALEASERALSREFRIAFLEKALHGCEVSLNEAKDALHEHDKGMQKVKRETQKELGVLQSQVERLNAMVVEKDARILELINDLTRHRNTVNELTQRKSDLLKQLKDMCEKLNTVVWETNQREKLLNNVESELRKREMERQAAFLSEVTRSKRLMVGIKVKENMLNQIISTKNKKISELEKHVQKLLAKISRINGVFNDINFGMESPIALNTCENQCSQVECNLASPCNVQVLSGRAKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0D0</accession>
    <name>A0A061D0D0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766319.1">
        <property type="nucleotide sequence ID" value="XM_012910865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0D0"/>
    <dbReference type="GeneID" id="24562674"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104420"/>
    <dbReference type="OrthoDB" id="366484at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28700" checksum="8984DFA72B81B8F1" modified="2014-09-03" version="1">MVYTSLTDIPRNLKEGIDWLLAVKGADAEKNLAAMGAALYDFLVDKPVGFTEVPALENVKLISKEFLERQEFKDMWPANELLGRFNNHVKTQNIDHLKYPFPINDSDFSNVVRARRAVPEKIAEDLGRIVDGCESFLEHIVLPEQYLSAYNSEATWKKSCSEKPEDCAVVLVGIAPMLYTGLYYLRRTSNPAHLKASLSRDVKRPREHLKVVGFKELECHAGMTGSDIRNALEGLNLQIMEKIYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0I5</accession>
    <name>A0A061D0I5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766487.1">
        <property type="nucleotide sequence ID" value="XM_012911033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0I5"/>
    <dbReference type="GeneID" id="24562842"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106100"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="85" mass="9810" checksum="0F85E24FEBCB39D4" modified="2014-09-03" version="1">MTWEGIVTKEHSKCRRDLGMSDRMESHIQRVVIQETHKIVMRDMKPREDYDSVEDPQAQTGWMPEWMAPVAFGNVPTGITHPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0T3</accession>
    <name>A0A061D0T3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0100710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765928.1">
        <property type="nucleotide sequence ID" value="XM_012910474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0T3"/>
    <dbReference type="GeneID" id="24562283"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100710"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="32"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="564" mass="62243" checksum="58EFC927AB499124" modified="2014-09-03" version="1">MSKHQKPGSTGGDVESGENGAKKQTEDYGTFGQVLYHLVSFTEGYEQQVLYLCMRLFESTMGFTKQQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSATSRFSSILFLRFLHGAAFGCIYPVQQKIISDKDEDDDRNSSSSTFTRLHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYVWISVGIAIVFAMQTDKELISPYKSIMGFVDQISGAFKAVFTNWSAFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDMKVGIAILVTTIGGAAGTAAGGIVIEKITSLHTDYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIEDKYQASASAIIQCISGISISVSFVEIFAYVSEKLHGYAPSTQAIDDMDAALKDNNTEALRKSTMYMIVIGSLLNIACYGALFATYKQDKENVVTENKVEWKEREARFEKREEIKRLVSERTLGEQAISKLPEDSDRLHNVLEMPVSEPEEEVADLGEEEAATRRYGRSDSTDGYLSSEEAIQEFIRSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0X9</accession>
    <name>A0A061D0X9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766652.1">
        <property type="nucleotide sequence ID" value="XM_012911198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0X9"/>
    <dbReference type="GeneID" id="24563007"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107640"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="11716" checksum="7F00BFC53187FF97" modified="2014-09-03" version="1">MLEELEFLRAYKVQIPPPSQYHNQGTSGVSSAGSGTSHGDSSNKPSTSHNTTPSTDTTPHFPPTNSVGTTPTDYAPRREWIEDLTEYETKNLWGKNKSHVISITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1K3</accession>
    <name>A0A061D1K3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766862.1">
        <property type="nucleotide sequence ID" value="XM_012911408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1K3"/>
    <dbReference type="GeneID" id="24563217"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109740"/>
    <dbReference type="OMA" id="ISMWELI"/>
    <dbReference type="OrthoDB" id="360686at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="27420" checksum="C5FC3AE02FDA89BF" modified="2014-09-03" version="1">MHGPASAAGHVTAAAATNNRAEGQPQGNGATAKADDQWQAMCEEEIRSKGLQLRGESLPNISDIKMTYREAWRTGKQGCLGVKRNLWDPHLFSGTWYFVCDGTDPNNFLVLHAHNAEQKGKQVVISMWELIDGYWVGNKCRVLYQPRNEDGSIASSATRTMVIEGFAREFYMAMIKCIHESQVRLQLMQLELKSLQDQFSRSKASRCKAAAPRVKRTSVKYSAASLVAAGLNSSALVYEAAKLKHARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2K5</accession>
    <name>A0A061D2K5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic initiation factor 4G middle domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0111210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767009.1">
        <property type="nucleotide sequence ID" value="XM_012911555.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D2K5"/>
    <dbReference type="GeneID" id="24563364"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111210"/>
    <dbReference type="OMA" id="EQHSRTN"/>
    <dbReference type="OrthoDB" id="366355at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="1215"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1139"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1185"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1323"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1538"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="785"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1185"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1539"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1564"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1600"/>
            <end position="1611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1798" mass="195192" checksum="B34788DA8329131C" modified="2014-09-03" version="1">MDRYPKRPQKKPSAVAPAPQGQATPLEGSADFVAMRGSSIPGSGDLVEMRRFPRNRSYGKSSFVEGRDRASFYRGPRMGKCASEDYHGPRARDFEHRMRYGDMTSRSGEVVEGNIFVERGDVQTVVDPDGDVRSSGEPVVRSARDSHANAHRERSNRNYNRAGGYQHRRPNYEGGEVSFASGRRSADRMVAPPEVDTQTKLPSPVSGDVQQVLNSESIEAAIREEVSQEFLRDGEGSGRMIMNEPRAPRSGAFGRLMKPSKGNQQRGYRMPHHMLDRSPMRNKVAAPFNRRPYRYDPMMPEMRANKSPRSPRYGMMHRVDSGMKGDSRYGTPSNGLMERPSHVHPKSPYVSKFSPSRHPGPAPYGMPVNGEMRPGSGEMYGVPMEDNVGRVAAPGHMPMNGGVARPVYRGGVPVGGVSGVPGLPVPGMVQGMSSIPVGQYVPPRWVGAPAPQGPPFGPPVTPSVDASVQNPVFVPPAVAPPRVMPVHMRKSSAFQIRNPTTGEVVNSDAKAPKVVKPKLETITPPSGGMVVHPVGEPVTPLNPMNGGGAPPGELAQGPPVGVPMLMPQLSIPQQSSPVMPMGQVPQPCSTVYPVMYPPSATPGYVPITPVMYTPPPHTPMTSGRMEEDELGLEDNHDPRHFPVASTPSQVMNYAKFVSTPRTNSQGSIGGTVPVTVNAPTPSIDTELRTAKNRVSNKAVELDDKLFGLSDRHPLCDNTIRVAVRDRISNRRVDNSAYAEPERDYAVDSGYMSDDESVDSHMERGGAKADSSRRVSRGDAHVGRASGQPGSSSGSEVSGSSPAAVGFDMLTLDSVMRDELSRFTRVSGRSIAVDGSASTDCKSYASLHSRIGDNMGDSRSKTYSCRASRGSDSPMDIEIDVTMIEAYANKQAEDGSDMSPERFADSTSAVAGSVPAGAQREFSPYDSHVRRIYHDVAKLHDMGFMDSVPEGYYIGADLMKREDDEVATGSPSAYSGVENARLEGTRGASGRKLAKSAVANVESIDGPCDVSEVTSRESAAAAGTAGSTETAPVSQTKALVDEGFRAPFGKGFHDDKAFAGIADPSTSEHMITEKDLFKGVVLGVGEAEGAVLRPGPLLLPQRQKSNIVYTAEDMLAYAFASGAAFNSLSLGFRVVNVGHGSEGGRDHRESRGRASGHFSHGGAHASQGYGANAGTQRPRLFERTKADNKWRRDAKPEVPRVSPFKKPDISREEQFKRSVRSLLNKLTVEKFLTVAEKLAVIYENLTIEDDVVSMVDLVLDKSVSELDYSDMYADLAYLLKYRFNSAFDVGSKSTLFFRVLMNKCQDSFETLSSVALATSLDPSAANSGGDVLGDSDKEDNDVDKADENELLGSVKIPRGRTKKWILGNIRFMGELFLRRILSVAILKRIARTLLQMDSDGSKVPCEYLVESFLELITTIGYTLEQNVNGPEMLNEYMEHLVLLKKHGNYNLRIVYKIQDLIDLRSKRWVKKVFKERATSVASIHYEAKQEELKGGAIHLNQEGKFTTAGRQAQRHYTDYLLAQRKLAMERTVNGVFVGNSDSAASGGDQSAGSGGAATSPQQPQSTGSAGSTARGGAASSSAPANDSPSANGDNKSSQGDDSARRTRRKAPEVHFAMDTQPISVVTEIMEVFVQNPRPERFMVEWDQFAPSSEDSLEAVRLMLNKCVNAKSIALSESQADLTAYTIGNLMNDVDTMVKALNIFETTCLVRIKDEMLDNPLAVSLFARILVQVLDCFATIPEITLEKILLPPEFDCAMDLAVQVLTSAKAQGGNVGYARELLRRSFEHFSDKSTQFLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2L2</accession>
    <name>A0A061D2L2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0111310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767019.1">
        <property type="nucleotide sequence ID" value="XM_012911565.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D2L2"/>
    <dbReference type="GeneID" id="24563374"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111310"/>
    <dbReference type="OrthoDB" id="366915at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1579"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1653" mass="180846" checksum="467666D51B29788F" modified="2014-09-03" version="1">MTGHGIELRTLRDCLQFLEWFKGDTDMQGKVAEELAKRCDTSYNHISYTGRLPDYFIEFLKNVSSFYHKLVNIPTAGNYGHKNGKQTLDALLECLPKFLAALYYIWYNVDYKLDAVGGGKWRDLYVGWENTWWGWGNDYGGGLQTYLRLAGSLQLELIPGGFGPDEVTYGYHDRTGKAYTYGSNMVNDLKNILNKQTHNEFRDISVTSVYSDAGIHMVNTANVLAMVKLFCETVRTDRDGTKLKGAVEEGIRTQNKCVDWPQLSEHCKDLEQQLKKFFNDKAFSHTGQVPKGNSLNTEKFMGETATWFRKHLPAIHSNVKKISIHYPADASIRLSKLQPFVTENLFPYGFIFGENSYGTMGNAWNTLPPKWKRVIGVLKSNNDGLAKLKKILDGAGCKLPKPVAAPAPRSPKPAPAPRPSGANAAVAQGTGGHHNTVHHIVLRGRGASGDGGDPQGQNNQVQGAQQPGPPAVEGPAGPSGQPASLATKTEATKTEAAKPHVQNTGGTPNQNNDQSEYKLPGPQVVTSSPDTTPGATGVKGPVSSNGDRGQQVPQSPLASKPSQVLVSQPTNNIQSPPSPPSAPERGAAGPAGGKPQGSNGGDASGDQPLAPPTAASSQPPSVPPPVPLQSGAPGSGSGRGKGIQAATSDPAQGSGRGPQSGASDSNTVSGPSSGSGGGGAGVGSGGPKKEPGIPKKDLDAERKKRWNAYGLEQQAKRTIDEEKMKSLIQSVNSNLHTIRQRVQEEALRKAVQENILQKTRIGQNAYPNKVNASTCSNDPSMHIGRSICHTNSTMPMPTTTSSHYLTPDVLDKIKIAEEQERAKQDEQRKRQETNDRHLRALHQGIEIETEILKQHAEQPTYPHADRLISEMNERNTKRDALGTVVPIHPGMEAVKLDGKATPSSKGIPRSTFPPISSNIDVPMGYSLKHKAPQWHDPPPPSKPVLQMFRAIPQGIVLNDNHQHRKSASGSRTTVEAPLLSQALEIDPSQIVLNVSGEALKNSTNDDTDLFPAPLTLDATPVPDHMQYKRSVDIYEPAVVKHDVPLTDILPKKRPPPVPAVPKNPFHTRTPFYSELHKPPDSITLFPGDPPSVTQDGTSCTPPWMLSQMGVSKPGRADEMPHMPNDSHSRFLYTDVLPRTVREMLYWLAGLRHSAVYDTLEKYISDLVGNYAKQTESLSSTIETVELAAVPKCIVGNEVTQALRLSCQYSIIVLMGIQGLHDPHIAYKNDNYSKAPQYEYSPDPACLLCQLRDYVYACHHQLQFLKSQCKRHQSHGGWRDCKYGSVITSPNSPLQSFLTDGWDSDFETHLFDPCNPCLKSRVRMGFKNVDLPKTSQLGSVISTILSPSCGGDDPLLTLSSYLNCLTRRTPRTTGELVSYFHYFGMELHNYASKSLSLLGSSLSTSHADCPDWDRLGASDLQAVSGIRGSEALNIISINNHDNEHPRTLSTLVGCGSDSATCHPHCSPTTYRAYALYSQSFAHTYLSWAVYLPDRLWESLEKLHYDLQKHRGSSKCSSLHSCPYALPLLYSHGFTPPEGILQSPLKCADVISKLKGIVNGGPIASLMTAMDEFLYNIREPFIFTLVALWSLASLILANTMLYRLDVLRTRSHLIRTKASHRIDVKALLTKGRKMLSLYKDVDYFDEDTLSQLVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2L3</accession>
    <name>A0A061D2L3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766488.1">
        <property type="nucleotide sequence ID" value="XM_012911034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2L3"/>
    <dbReference type="GeneID" id="24562843"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106110"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="422" mass="46793" checksum="613F4489DF7F4629" modified="2014-09-03" version="1">MVYKSLTEAPHNLKEGIDWLMAVKGTDAEKNLKALGEAVHKFLADKPVGSMKVPTLEKIKSVSKEFLQKPRFKDLWYVKDMLDKFDGPMNKTRHMWLKRQTANYHSDYENIIQTAGITAKHMVENVNDVVDGFEKLLEKVKIPDQYKSAYTSEATWVASCGKRPQVCAVVFVGIAPMLYTGLRYVWDSARAAIRNGRNSSEEMGLKDVLKAVGYEEPGCNISISSSDIRSASNDVHPYILDKIYDIGGFWAFYGSQNVVTANDIEAGISDGVEEVMEPVEVEEPVDDVSGEEPVNAANVEEPVYSVKASEPVNAVNVEEPVHAVKASEPVNAVNVEEPLYTLRDVAELQHVEHVKPVKTRKFYMGSREVYGIPGVDIDMGLVNAWNFRKGKKPVKTLTGLGSDNIYYPGAPTVANLNAASFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2M1</accession>
    <name>A0A061D2M1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767029.1">
        <property type="nucleotide sequence ID" value="XM_012911575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563384"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111420"/>
    <dbReference type="OrthoDB" id="366943at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1731" mass="193848" checksum="F9A8F7FC0CACCF9D" modified="2014-09-03" version="1">MGFLSGVLGAVKNENEVTTYDNYISDENKKLNKVLEKLTKNIGSGRDGLAEAVDAVKEWLEGYEKKLDEKNKKITSPLNTLITEIDARMKDIPGKRNEDYDSVSGNFAAWLMGVRRLASKPSVSADRVKKLDPKLSGELSPHVDMVSQAVNTFVDNAKRDRKELETACSKVQVELRELEREVTAYTTFKNGKCVEVLQEEFDDKIKRPIENVKSMLNGLNIKLNDWIILANEVVEKALSKCTEILDKLKADGRGEREAVRKAAEELHSKADSLRLFVVEAKKELTNLVEKALSQVVEFDRAIRTGLKNTKDNIKIAMEKYVKKQLLSDIAATMAEITGANEGDGLKQIIERVQEYAKKFSEKETFRNEILKQWINRILVTEPVQECLKQYAETPGKNALLPGKWNSPGRKFSEGTLEEIASKISEQIEKTIPDAFQSAGVQSLASIESHVGIAKRACDAFAMRLGDKIKTDNGMRLLASEVSKTIERQLTGKGEAEITAENVKLRKPVYAVIYQLVGVANKTAEALESFSGETDVSKLDIGKLHAAYKVAEGLEKELMKATKPTDPFTPVQPIPPSDVLDKNDTYSYDRKILGILDSEIGMENDHGRGGQVESVVAKSFDLYETYLSQSSVANGKLGDADNEGKLPEAIKSIVKEVNGIKHLGLVEDGKHKRTTNDNFNKDTFANLCNQVTEAVGKLCDVVRDLILNSDGDDSDHVGPYLSGKKGLHILLKDLEAMLGRNKGISTNIFKLNTGLQTIHDDIQSKIIGDARNADLDKPTTLTDVIAAAQIFYSETIRNEINECISDITAKLKEEVTDKIDNLKKSALTQFAKRKTAELEELKKFVHDQKNIIDNIIFTNQTTGLKGLMNTIGTNLQAYVDPLRYPNVKDLSKHLDFYFNPLFTYIISQTNPSSQLVADLQSRTHALLTHLHDNNRTFTFDSGFRSLLHGLTTYLSTFNPAGFANPHHPQLLDALKAGMQGLVGEMEKAYVNRYDGHPKMEWTTQNKEQKDEITADATRCAKVFMSCLPMWVEDLGELKRRCEGSWSKKAIHLKDEIDKENPLGEFLKQCGYRVPTSQKSHQDGELQCRHTFTGKHIDGILGKIIQMSNLEHVPQCRSREKEWNFNIMDFIACLYSHLDEYNEVCHLSTLFSKRHPCSIYEILCWFSGLPHSTVYSALPGGITKLLDKPKKQAIDSGDSGIEIEFDDENAYYLDAHPHKFTYKDIYAVIELICSKSYDVLARIAGTGDEHTRYACEYANNSLKLHYPKTADDCLPMLLDMLRRLLSVFRFLESKCSYSAVEFGWADCQYGKNVPTTKSHCNDRSTDEATCQAECKPKRQSKCQPNSQPNCQPTSPLMSYLNDCLPGHLPHQLTNVGCKSECKTCPGNKPGMPCLTPLGFRGFSGSIKTGEQLCSIIKKILGNGMIACLFTLAPRPPTTLPEHFQFAVSLAKGLDTSKQSKVDGIKTLADTIANSINASSIKLYENTNELTTPMCKAYGNTPTEHRSPNRTNNKLNLSCISLTTSCISQEHCVPYLSPLSCDTYHYLVNKQSNSYLSWAVYLPWTFHKYLASLLDAFKAIRCEDWGCSNCLHTDICKGESHGMLNPAEKGTGCQCTSVVHCNGVSPTLYQYGFTFRDAQNLISLKRNCFNMRSHLYNVVNSDYFTELFKQCDMLLWRIREPFSYLVLTLWLLSSLYLLHIKSHLHSPSSHRIAAQSLLAAARVGKFAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2P0</accession>
    <name>A0A061D2P0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0106410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766518.1">
        <property type="nucleotide sequence ID" value="XM_012911064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2P0"/>
    <dbReference type="GeneID" id="24562873"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106410"/>
    <dbReference type="OMA" id="DNVDFHM"/>
    <dbReference type="OrthoDB" id="366242at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600547" evidence="3">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="433" mass="46775" checksum="1FBF7771C5FBD5CD" modified="2014-09-03" version="1">MRIFITVLLWLAEMHRTATALTLRGEFPRSPRINLLELESTRWEATADTVSAKTAPSSNAKLELSDLKDNVDFHMNHLSEALKEKLSNAIEVVDPVEMERLKDACDKVENRIRDLQATIKSKCDEEEEIVNQQSGDHESAELHGAVESAKKRLKSFVDDGIKEIGEKLNNLFAEFTVSETEDANKTRDGDVNENAKGAGAATGDKSVKEMPDAEKPLSKSMIQVSGDSAYEESGSIIPKNQISDNTVKEGKVASKQNVNPGGGQMGVPKSNASKDVKHAEVAGNASDALKGQSNLVNSKNQSSNIIRGEVNGNHDDKRAHTTSEAGAATNVTGNTAMTNGVTQHQGSPDKPNNIEAVQSKEAGENDDRRKAGASDNAKSAPAPKSEAEQASKLAKVPPAAITRTVNQYLQTLNSEADKLVTDIQLKLHRTKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2S2</accession>
    <name>A0A061D2S2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0106810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766558.1">
        <property type="nucleotide sequence ID" value="XM_012911104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2S2"/>
    <dbReference type="STRING" id="5866.A0A061D2S2"/>
    <dbReference type="GeneID" id="24562913"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106810"/>
    <dbReference type="OMA" id="EHDPYRF"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="233" mass="26029" checksum="D867A88DEA9A5D21" modified="2014-09-03" version="1">MATAEASKRDPYDEAENTVRKNIRRLIVLQSQVMEELSTLPKHTRVCATTKGAELLTVCAGIESDITELQKVIDTIRKNEKKYRISAKVIASRQTTIDEFRSKLKSVRDRNEANDNEVANAASSPPSNLGNSLVEHQLQTQKDLLEQQDVQLSVLTTSAQSLQNNALAINTEVTTQNELLRSVDEGFADTQLRLNAFSKRMAVFLDTNNPSLLRLVIMLFSIAVILLMVIIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2U7</accession>
    <name>A0A061D2U7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome C1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0202530</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="14">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767282.1">
        <property type="nucleotide sequence ID" value="XM_012911828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2U7"/>
    <dbReference type="STRING" id="5866.A0A061D2U7"/>
    <dbReference type="GeneID" id="24563637"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202530"/>
    <dbReference type="OMA" id="KNRHTDY"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000011">
        <property type="entry name" value="Cytochrome c1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="17">
        <location>
            <begin position="177"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR95096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="397" mass="45610" checksum="3C72BF761D0309CF" modified="2014-09-03" version="1">MAGGGGALNKIFPGYKDKLWNKMPLKWRLNKIKLWNAKAVSSMYDTCVTTNTKIKSFNKYILDPLKPSYQYRQPAVDYKKQRARGTLVEGVDFYLPTPRAQQRLANFFEPYTEEENEERSKYRYQSLKTYIYVAIGATVVHNWYQSRPIAWCSDLNPPKAPYYPFWFKGPFHGHDIGSVRRGYEVYRQVCATCHSMQFMRFRHLANEVYPEQRAKQIAEEYEVEDGPNDEGEMFMRPGVLTDPFPSPYPNAEAARYANGGAIPPDLSLMASARKTGPDYLFALLTGYCDPPEGIELRQGLYFNNYFTGGSIAMPPPLEDGMIDYEDGTPATVSQMAKDVVSFITWASDPMHDERKNMGMKLIFGATLGTVAMSLWYRFFWAYLATSRMDFGRIKHMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D355</accession>
    <name>A0A061D355_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mac/perforin domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0202000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767229.1">
        <property type="nucleotide sequence ID" value="XM_012911775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D355"/>
    <dbReference type="STRING" id="5866.A0A061D355"/>
    <dbReference type="GeneID" id="24563584"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202000"/>
    <dbReference type="OMA" id="RAPIIEF"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600560" evidence="1">
        <location>
            <begin position="21"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="2">
        <location>
            <begin position="72"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="696" mass="75950" checksum="76F96A935437E25F" modified="2014-09-03" version="1">MCRTIGLIISSLAFTVLYEARYAVSTVLEAESGQPELQSELPFHVEGDDSDELADAVAEDPFDDGVEKMLEVDSNDDEFDKGTPGIDFLGIGYDSIFGSTLGDEDSLLDPGYRAPIINFSWRKNAEGYSPSLKAVYPLHGWVRPVYSCGRSSKIQEIQNVDELKKAFSASAELKGEVPTASFSASAKYKKEAANIAHKRERIYLHSDICIRYQAGIPLNIPWETTGEFKEAVDALQPLDNAVKYLCSINDIRENATKEDCAALKRWINFFQIFGTHYVHQLLLGGKLVQTLKFDASALENLKSSGIDVNLAIASSIGSVNASVEGRRAAETAKIDELGSKTITVIGGQMPNLPITDEEYATWGNSVAENPMPIGMSAESIKRLLKTELKDSYTLALNKYAELNGITYEMLNKIAGNHGGLVREIKNGQPTISFNNDGNAAKCSKGQNVLFGFSLLFDKEETIAGLIPCKTGAQQCNVPMNKVDIRSVSWAICTAGLQPNISQVSDMTSRHSVSFNANLTFSWKENYGLSVFNSCAMQRTATSSCPHGSFVQFGIAIRGRRGTLILINECKKGNNGLKSCKSESGHGETAATWIVCSPDAEKSTKVKLLTEIVKGSKKVECEKDEVVIGGKKNELCAMVVGATVIIKNDTNSASKSPRNMKIDVCEQYLNYCKIECENDCHQALAVVMCASTYKQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D384</accession>
    <name>A0A061D384_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766738.1">
        <property type="nucleotide sequence ID" value="XM_012911284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D384"/>
    <dbReference type="GeneID" id="24563093"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108500"/>
    <dbReference type="OMA" id="THITRFI"/>
    <dbReference type="OrthoDB" id="361700at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1186" mass="131972" checksum="5D0BC329AE4CD308" modified="2014-09-03" version="1">MSLQFLREFNKNVKESLSILNEGFEITNGVTELNNVHLPYINLLKRPEGPDDIPLCCIFGPGGYKRATGDHHASEASSVARVTESTSATAAASDVMDAPSASTTEAAESAGDDGTAEASSPQVEVEPSRCPLGDGCILKRIDASRFQSAITSVIDILKSVENVLSSTSVATRRLLENQVIPALCSLLEVSEIARLFHRPQPALSQKFNNTQTVHADLLGIVSIVLRLMDQILVYPESITKLKGRKVFEADISPRLQCNAADVSARVVAKLAGDVGPADGGSKSFDHYDCPSGYEYFGKVAIVSMTEAERDSLKHLLGMLNTVTIATQFARNILTAAEMCIDGHEMLERDVVTYSLGIVEKLYTHNDFSWHLHQADDKYLYTLDILDACYVNWQLAYKGVCFSCDHPLGIADIPESIPSSTHGTICNCVISRGDHAAPNRHLIEKELVDSEVNPRRLMRLAKESGDMTLRARVTGILLQWMLNSASFQEHFVSEGCIGLLLDVLNGCYVDQFGLLNDSLAEIPAELSKKQAAALESELAIGMSFVPCSIECILMLRHCLRFGRISDTDIRPVIKFVTQLASTVLKIWIFYYCTKRGSARDGESSILRQILCIVLDMCCALVRPRIVDIGATSSQTGQSAGNPNHALSAVKHLRNCAKSTHAQHFSELIETGIAEEVMYALYVLCNRTRFGYEAPEHVVDELMRFIATVEIASRSNVEVADLLMNKIHMPIGDRMPAVYAHVMHDIQTRDVENLKLNPIVSPMQARLSRFRMEIFGEIAETPVLVLLLLCLFDSDVVVPFKAPLWGCSLRLVVASAIFERNEVAADIFEYVRDVYGDSLTTLDESAETTEKRPELRHLSSMLDMSIILFDSGLEEASRDKLINDDPWTIGTTVLAASVKLLKVKFVSCMSIFIQQQSSDDYIALTVKALSQLALYLSKRHLCTELGDVDSSPITECMTAYKDAQCATVTQLAALVLALLEARGVPLHDKAALQTIVTVSESLIQLHRNERHVRALRLMTDLQPCRRVDGILRSYEDTLEVFLAEVDSVAESDALGVVVWHRTNLCEFELSPRVHYVMERFRWTLQMHVIGRMVDSLRDYALIHVDDAKRISSKTAEEVQRMSHLHAEEIAFAQERISKLNKQVDIMAMSFYKAEDMVTNYKNELEEMRKENKKLRKRLKKAGSHKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D390</accession>
    <name>A0A061D390_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766743.1">
        <property type="nucleotide sequence ID" value="XM_012911289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D390"/>
    <dbReference type="GeneID" id="24563098"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108550"/>
    <dbReference type="OMA" id="YITHFVH"/>
    <dbReference type="OrthoDB" id="282383at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39767">
        <property type="entry name" value="CALCIUM/CALMODULIN-BINDING MEMBRANE PROTEIN PCM4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39767:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="28614" checksum="3DB39E8CFCE6EFA3" modified="2014-09-03" version="1">MSSELTNMTDDIPNQAPDSTASLKVGRIQFERGNSYSQIDETDGAFTFRTNNIQLKLTTDKFECLSKFKFDGKLSVSKVTSGEVGQWVLWNIDMFDPGKISPWMPGNISSCGRSVDFFLGGPCKLSKGRVNRFYFGIPQHSEIRLTGRVHFFDQWNGETLSLKVDNNVVWSRKCNSASPDMAPSEPHNWCPTLSNADCVRFGIDSCGQEYPDRISVHYDVSMRHSGGSMAVEFSSSLETDPCEASWGIDDVAVYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3I7</accession>
    <name>A0A061D3I7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U5 small nuclear ribonuclear protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0204390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767467.1">
        <property type="nucleotide sequence ID" value="XM_012912013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3I7"/>
    <dbReference type="STRING" id="5866.A0A061D3I7"/>
    <dbReference type="GeneID" id="24563822"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204390"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="131"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="999" mass="111374" checksum="770FDA73E3FAA69D" modified="2014-09-03" version="1">MDQELYDEFGNYIGPVLDEDLGGGIDSDGSAGDGEAADTVTRLGPADVVEYDGGTAEESPFKDVEVFIQHEDTQTIEEPIVKSQETRVERVSYIKRLDEDISAKSFDILEERLPRNRFSFRFMTTLMRQPQFIRNVCICGDLHHGKTTVVDRLINYSRFPDPDAAEGFDPSFVRYTDTRLDEQAREMSIKATPISLVFQSEAGTARNKAVKHKSYLFNIFDTPGHVNFIDEFMHAQSLCDGCVFVVDVLVGRTSTLELMLKSAIKNGTGFCVILNCIDRLVLEMKIPPTDAYLKIRHTIADLNEFVKQTSSLTQTDPVVLSPLRGNVLFASSKYGIFFTLESFSAIYAPDADPVRLAKALWGDTFYNPATQEFTPDEVVAGESDGENEGEVQLKHSFVAFVLEPLYKIFSHVASDEREELTPILDQLGVSLRASDYRMDTRKILQKVFAALFSDPSGFVSFVVENVPPPTETGALKLQTLYTGDRGTAICSGIEQCDPDAQLMIFVAKNYYRLDTNAFDVFGRVLSGTVTKGQRIKILGDEYTLDDDEDMQVRSVGSLWIAEGRYRVEVNSVSAGNWVLISGIDLCSHKTMTITSAEDPNGAEVCRLRPTVLASEPVFKVAIEPLNPSELPRMVEGLRRIDRSYPAIKTRVEESGEHVVMGTGELYLDCALHDLRRLYGDLEVKVSDPVVRFTETIMEQSATKCFAETQNQMNKLCFIAEPLEQGISSAIDEGLISPELPDSETSALFMEKYNWDILAARSIWCFGPDNVGPNILLDDVLPSDPVKAAVGTVRSAIMQGFNWACKEGPLVEEPFRNTKFKLIGAEIATDAPMRSAGQIIPATRRAVYGAFLLSTPRLMEPIVFSEIICPADCVASAYSILSRRRGHVLKDVPKPGTPFYEVHAYLPAIESFGFETDLRVHTHGQAFGITFFDHWNIVPGDPLDKSIMLKTLEPAPIPHLAREFMLKTRRRKGLAEDISINKYFDATMLQALGDELEQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3K2</accession>
    <name>A0A061D3K2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal subunit protein S14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0203200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767349.1">
        <property type="nucleotide sequence ID" value="XM_012911895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3K2"/>
    <dbReference type="STRING" id="5866.A0A061D3K2"/>
    <dbReference type="GeneID" id="24563704"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203200"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="16942" checksum="051EE47F0A3715EC" modified="2014-09-03" version="1">MSSKKASKAGAEGSGETAAAAPAAAASTPLGPQNKGEQVFGVAHIFASFNDTFIHVTDLSGRETLVRVTGGMKVKADRDESSPYAAMMAAQDVAARLKELGITAVHIKLRATGGTRSKTPGPGAQSALRSLARSGLKIGRIEDVTPIPTDSTRRKCGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3K5</accession>
    <name>A0A061D3K5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766843.1">
        <property type="nucleotide sequence ID" value="XM_012911389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3K5"/>
    <dbReference type="STRING" id="5866.A0A061D3K5"/>
    <dbReference type="GeneID" id="24563198"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109550"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="18532" checksum="D8E0FC01BFB50700" modified="2014-09-03" version="1">MIADTLTETSLYSASVIYKLQHINSKDAFSNFNFKYEYRKLHYSPDPACLLCQLRDYVYACHHQLEFLKAQCNRYESHGGWQDCNYGSDPKTSSPLQSFLTDGWDSIFKTHPFDPCNLCLKSRVRMGFRTEDLPKTSQQGSVISTILTPSSGGEGHDALLDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Z1</accession>
    <name>A0A061D3Z1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CGI-141 protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0204410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767469.1">
        <property type="nucleotide sequence ID" value="XM_012912015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Z1"/>
    <dbReference type="STRING" id="5866.A0A061D3Z1"/>
    <dbReference type="GeneID" id="24563824"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204410"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="135" mass="15096" checksum="9113DB523EB3ABBF" modified="2014-09-03" version="1">MERNLRLGFALLCLGFITGCISILLLFDPLFFNVSNVFMVSGLYFILGTSKFITFFTSSYRAKGSAIYFIGIFVALIGWTKIGFILETYGLYVLFGAFLPNVISYIRVTPFSFVLDLPVVKNVVAYVQEPSSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D428</accession>
    <name>A0A061D428_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765920.1">
        <property type="nucleotide sequence ID" value="XM_012910466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D428"/>
    <dbReference type="GeneID" id="24562275"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100630"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="233" mass="25353" checksum="4A82815178AB9299" modified="2014-09-03" version="1">MAYASLTEAPRNVKEGIDWLIALKGDDAGRNLTSMGLAIYNLLTHKPVGNLNKPAPEKVEEGSEEVEGQSGQESVQSLREMSTRALAENLAKLSNNERLAVRIIALKLSHVILACQQFLDDVKDGDRYVSAYGPEATWDVSCAENPEECVSVFVDVAPMLHGGLKALRKASDGKILGIPSAEDTERVQEIMKAFGYNESEERAEMTATHVSEALRGVKKIFGTLHDIAILCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D432</accession>
    <name>A0A061D432_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767499.1">
        <property type="nucleotide sequence ID" value="XM_012912045.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D432"/>
    <dbReference type="GeneID" id="24563854"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204710"/>
    <dbReference type="OMA" id="HEQLTYP"/>
    <dbReference type="OrthoDB" id="366477at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="919"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1445" mass="158191" checksum="B0B41E9963DE0DBE" modified="2014-09-03" version="1">MDVEPFERLQNDASCMASLAKGLVAGPMEVMESICKFVINAEKSDELSDEGKIQILKSMKGICRSLSKSIDEKYGLTAAFKSELRGSELEKARMLFYYTVMKAFRNEMEKRRHRNPDSEHDAVRKMKLQLMNLDKEISQLKQQLSLYNRVKKRINQSKLSTQGIDENRTDVEKNLFQRDFRTMMIAIQTMLRQHNIATTRHVKKLETKNDIASKAIFDATENINSQLLHRILEKSNWYKDETISSESATPSEVVDASKICDENVKATETTESLAKDEMVVSDVASAKTIVDTSDKHVDAVCEVTPKDAYDSEVVEQVDDELDATGVDKGVESEAALVAGSEPLSVTAEDLVSELPNPEADAEVILAQEAEQISPISHEAVDAAVEHDEPAAPMGEDVNDKSVTEEVEPSAMLSEEAVEEEKTTAEVEEVATEVKEAAMVSKAVIKRDISISMQSTIDHNADEDIVATNSMESVNQEMAGVSNLAVDSASDDAVEESVDENVDSVENTPVLETPEPLNATLERSDEPTEDVPEVANEISESVVANETSEEIVANETSEEIVANEISEEIVSNEISEEIVANEISEEIVANEISEEIVANEISEETAANEISEETAANEISEEVVANESFDVDTTNVASCPSPDLAEVCDMSSGETCELSAPEENAMPIAEEESVIPLSTRNDTLSEPAEVSMPPHPQASPLPENSSSSVPVGMPMESDVTPVESTSLALDTDLDIITNTDAEEPTQETERTADEETDVNYSMEDDVSERVDNEVSATTITINKNPSLFKIKLEIDTNELWNEIQNLKRDIVDLKDTLVSLKSRVNVPESGDKMVDEIPPLSEAEAVDDNADAAIIDNTVTETSNNENVSFVEREITMVDESPLEEGSHMAVVDDTNVEEPSQTPANVLEGELHEDVETELVTDPNESLENVVDSEVEESKEDLETLKPEDANLVAGDSEGSCNAESTNDKSDSPENDTDIVVSPVEESELELNNLVVELDKSNGDFVGGARDVDTPYHSAFFDVPSTPVESLTPTPYEQPNQTIYFDAETFGSYITAASAEVAENKDSLTTPNIEAALDVTENADGNANELMSNENSLETAITNETTATDANEHGEVEPITEETNISDEPEITNADCDLEAEMLHETEEQAEITVESEEIDETVNAEVDTISAVEKEANAHEMHHDSLSDVPSTHGDANEGLASVESTDNLLTKEEDIIAPGADETERGDITRPTSSDNCPKPTERTEEAASTSVMGVENTARSDILDDDEFVKEIIDELGSLDKADDEALLRELEELYTIMTQQLVYGTTTGSLDDEASSCMSLEASDNEEEFDNGRFKQRKAGRISDPSNVAEYASEDLKNTRALNQYNDEESTSFFNGLGATAAVQEENTVTTKGLPFFVGIFSQIPQLSQPISTETIEKQYEEFKQFQAFISLSSRKNQNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D478</accession>
    <name>A0A061D478_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767564.1">
        <property type="nucleotide sequence ID" value="XM_012912110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D478"/>
    <dbReference type="GeneID" id="24563919"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205360"/>
    <dbReference type="OMA" id="YNHWLRN"/>
    <dbReference type="OrthoDB" id="438538at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="193" mass="22718" checksum="6162DBA66DCC8ACD" modified="2014-09-03" version="1">MVVFKDVHHLRRVCKNLTNNNTDKRLQDFFFQRTYRLWYNDSTQYVYYLLSAVTIGVSVVVGFHELDGNPDVTGRSRHARLQLPDRLMLHAHAIPYYNHSLRNFAMRFTASLVDNEHDYSKETTHGKAVIALIVHYLHTQTLNAAYRPNRAKHYGRYPLVFSAPKYFVDCPEYDSTLHKNVENRYKVGSNEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4F8</accession>
    <name>A0A061D4F8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766000.1">
        <property type="nucleotide sequence ID" value="XM_012910546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4F8"/>
    <dbReference type="GeneID" id="24562355"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101430"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="8455" checksum="428337FEE029FF44" modified="2014-09-03" version="1">MGARMDGTSSARQQEREEPSTKFSVRRQQRQTENRLKARSHIAQYRIRQHNNNKQCCITLSKYLNQNMNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4I5</accession>
    <name>A0A061D4I5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rho GTPase-activating protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767674.1">
        <property type="nucleotide sequence ID" value="XM_012912220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4I5"/>
    <dbReference type="GeneID" id="24564029"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206460"/>
    <dbReference type="OrthoDB" id="10537195at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="441" mass="47270" checksum="2E4D5B0316A24D04" modified="2014-09-03" version="1">MNIGRICISAAAAAAMVTVGLLYRSYDGWSNPGGSAERPYLSNAVQAAADFICSGPSQILDVEINEDKRLSSFSSSYDAIDSVEDLDDYSDLYFKEDYWFSKEDATPSSVEPSEAGSDDDDGTSSQSIVGIPCDALVVEPVVTVPLSSTRQNDIDMHSSSDTHEPPLITRKRHLKPLRLHIPKPSVVFEGDAVDEATPSGALPKHSESHARGIDVGSTAECSDDKVSGVVHRCTSWQPKYASVIESSANAADSSLEETFDIVDELEATGWDTLEDAPLIVQPNTAEDAYVSPPDGHPSGYGSSIQGSSADPSPVTAEIGSTTSAHKPLFGVYPPGSCVFVKIPTAGEATRDEYATAVEPVSLTVLLSEMNELELLVSNVRCTMEGILQRHANELYGKYKTLQFTLKGAANILSQLEKQIALTLDTVFEMESDMASKKSTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4V2</accession>
    <name>A0A061D4V2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sma protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766170.1">
        <property type="nucleotide sequence ID" value="XM_012910716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562525"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103060"/>
    <dbReference type="OMA" id="SWWFIAN"/>
    <dbReference type="OrthoDB" id="5527234at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_119, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="441"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1558" mass="176961" checksum="23B34D4222351551" modified="2014-09-03" version="1">MVKLEIWEQRDHAESSDSSEEEIKARRLPLFDRVLPKAPVSRLPQQESDTSSDSDTATEDEDTSGSSYFHSVSESSDAAEEIASENAEYDADWWRLQNVRATSRFSPATYGDWRSLPRAWDSVFYISSMHNLENAEQKFFYCIRVKHVNERISRASGLGNIIMYTPHFTLSPGEDRKLQTPMFIWRKRRLTLPYGQLENYVIEIELWKTQMLRINSLYATQQLTFQEIVDRKTNFSVTLNMYIPERAAAAAGGSGDRPVAKKNAAALTESSERRFPVHKMTMFLLLEEVFDFFFVFENWWFTRAPELPSALIDMPKMLRISVPSGMGKSWHTSSTEASEAAYWSSPGTFRFQGTLRQLRYASFRAMVYCVKKSKFFTKPPALLGTCVLSLQSVQELPLVRGVVKKLTLGTRNMFSGTIQGNIRCCMKSCTVSFFEDLKVRPAQPISGSALITQLDHRCQYLVVRIISCSSLPASNTDSNTSDPMVKVKWDGIFNCTGVVESTVSPIYNQNMYFPIHLVDMRELTDPALIKHSLPVDLSSKGPVVVEVWDHSDASSEFLGSAEVPLSRIYTNGVLQRRSLADGIFTSAGYEVDESGSDESDYDNNIACTDDGASNAVYTPHVTRLYEGTLPLVGSTVDHRRKKPLVSLEMYILPPMPNDLYIPDDQKKLKRRDIYRNLSLRWTREFDSWQGVYCDRFPGAIARRRFTCVTSDALNMHESLQSDLVPLCYFVKPIQMYIQLSPPGELMHWISNFTYKNDGTATIGGCVQIETWQMPSRFVLTRKGGLHDRALLLCSCLLGLGYDAYVCKGTLEGGNREHCWVMTRHSGGTVTFWETANKRMWHMPMRWQRSRTVDEAKPADVMEHSGNYVNIQTSQQRPFEAPQWSRGTSQKPTRRLMNYELYGNDYMADVKVDLHRMMNSNEMLPDGSSALPVGTGFIYDTTARNVSSRRQRSIHPKKELLVPGSTLVFLPYSSIEVVFNDKQLWGNVQNHHPACITYDLEAPEDWRPFLKVPITDSVMPDVQITAPPPQNVCVSTAKEIRDDVVEMIELMYAQRGRVANVARDQQMDERLESLIDILEFRQRLDPQFDPGMPPHLLGWSTKTPAKTRNAQKSKSDKGEEVKEQTHADAEQKASLPITLQGHVMGDAAGKCQPARSDMEIVHQLAKAVKNDEGDSDYSDDTQASTDDTIDFNPATVPGRHTMEGNTRRATPSNQHPAGQQRAPPARGLRLISRMKALLSSAPKHHAMVITDSCPSTPNAPVTHCGNAQSSSKGFRFRKTTIKVVAPRIDVARAISNASAHLGYSNIQEMSDYEFEVETENSMSSGESNTDVEVNTPISNIARVTGVIPHNHPLSDYKQRIVSAIHLREPVKGRKPQQPPARPRPLKMPGAKQRPVARPQKRPRRGLLRNLWRRFRAEDIPDAHKVPDFMVDMKEVVNERRFNEQYMEHQYTIPTEFLIHEDKQISKWNWYYNMEARQYAWRRHLPIPPNHTFIGVPIRFSTSDINEIRNLLTCSSRCIKMLVPDVDRCVNVVYVKVFPLLGGVLSTWLFLGCHVPWNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D514</accession>
    <name>A0A061D514_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0209290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767962.1">
        <property type="nucleotide sequence ID" value="XM_012912508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D514"/>
    <dbReference type="GeneID" id="24564317"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209290"/>
    <dbReference type="OMA" id="SERIYGF"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="37"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="578" mass="63446" checksum="0332A05FF3A6DDCC" modified="2014-09-03" version="1">MSEVSGVGADGVDGAAAGEPQQTQAPKKIKAEYGTFGQVLYHVVSFTEGYEQQVLYLCMRIFESTMSFTKSQRTMLMTVSIMSRLCFSLVWGLLADAFETNLVMAAGLLFMGIASILLSATSRFSSILFLRFLHGAAFGCIYPVQQKIISDEDDDQEGGSSSAFTRIHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYLWISVGIAIVFAMHTDNVVTTPYGSMDKFVKQISGSFSAVFSNWSSFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDMKVGIAILVTTIGGAAGTAAGGIVIDKITSTHAKYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIPDRYQASASAIIQCISGISVSVSFVEIFAYVSEKLHGYAPSTQAIDDMDAALKDNNTEALRKSTMYMIVVGSLLNIACYGALFATYKEDKEKIVEQNVEVRKERNEIQVKREAMKRQAQEEAVAGEDDLSGISENTRSEKEIAALPEEVNIAGEMTEDRQDRSRREEDEPLSPRAIQEMLKRGERSKELESRLQELSTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5B9</accession>
    <name>A0A061D5B9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0203900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767418.1">
        <property type="nucleotide sequence ID" value="XM_012911964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5B9"/>
    <dbReference type="STRING" id="5866.A0A061D5B9"/>
    <dbReference type="GeneID" id="24563773"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203900"/>
    <dbReference type="OMA" id="KAYTDHH"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34408" checksum="1F77023BAD948215" modified="2014-09-03" version="1">MPRHACFFGKYLRLKGEAIRKGFKKNQIIHPIPVKAYGRVPSAASQTGLYHDEDFNYYSKVAFSLKRTRVKLKPNVFKKDIESRLLNVTIPNVRVTTSAIHAMTAAGGFDNYILDTSPEHLRSQLGERMRSVAYFYKQFPDIRALQLPWKVFYSEHSRADPAFAIYKHAMAKQRSEEKAERDRRRFSPFYLPPSHGLMPERQKFRTPGSGDGAAAGDPTDTSDVDAGAGAAARKLDLWWKQEGREAEFRLRLGRATGFDAAHVDVDMQGAYRKGGARGGGGPHGKSVRRRSKTFHPIHRHITHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5D3</accession>
    <name>A0A061D5D3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768102.1">
        <property type="nucleotide sequence ID" value="XM_012912648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5D3"/>
    <dbReference type="GeneID" id="24564457"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210665"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210665"/>
    <dbReference type="OMA" id="RDEDRYQ"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="18165" checksum="2050D7F2FEED83B7" modified="2014-09-03" version="1">MTHEQHMTGSAGSATAATSGASATTRESRRLVTRRQMLALCVSAATVLGLSVFAEEFFSHFKGVGEEDDDDVHVGRTNERRVAAYFNPATSRWERIVPPFVPPAPAELLRHYGDLDDDDFDEAQVAAALPKREFVVMERPFSQTYRPTLLYDTRSGKLVVFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5J0</accession>
    <name>A0A061D5J0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768177.1">
        <property type="nucleotide sequence ID" value="XM_012912723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5J0"/>
    <dbReference type="GeneID" id="24564532"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211380"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="66" mass="7397" checksum="11946CB319B72B2F" modified="2014-09-03" version="1">MWVSKAMNGHVQLNDVGIERSKVATSILVADVEFRPSNIAHCIPYHEHNEVFCYKNPTTSNIIGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5K9</accession>
    <name>A0A061D5K9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA repair endonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0211550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768197.1">
        <property type="nucleotide sequence ID" value="XM_012912743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5K9"/>
    <dbReference type="STRING" id="5866.A0A061D5K9"/>
    <dbReference type="GeneID" id="24564552"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211550"/>
    <dbReference type="OMA" id="SEMCSAY"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1211" mass="135992" checksum="D8B6B6B8F0E32F52" modified="2014-09-03" version="1">MQPLPFEKAILRRFVPTWQELVCQHIVQGVLTRADLCIEKCRKRRAKLAGHRKGVTNALLILSPGTDCSRLLFYLLLYVLNPLHVYDSDAYECRVEVSSDLPRRAPQLCLQNAELALRSRKVYHGIFDLASGDGCDSADAKGAILPHVFHNLKLRSAVEVGNRLILVLGLGHQEAVSTARHFAHLVRGLCHSSSETPDNTCVKIPQPRFIDGSVVAQEREKMYIEGGIFGLPPRILLVDLLTAKLAPELVSGIVIVNAHRMMQDYNIPFLIKLLRTRNRVAFIKAVTDNVVSVREGRKLSFILKSLFTADCFIFPRCSSCYDRVLNDPSVQPETFEISMPLSDGAKQIHQAIVQVLQRLVADMQRQGSQELQKLDMNTIMYTNNVKALLVNALQRAHIPNEYHLKRTMMSVTNLRMLLDQLINMDALSFLNFAEDMKAAESESHWLWTPLGATIYRLATARVYEASNDTGAGLKVNMELDQKGECIRRILGDKYVGCKELGELLRTAMNWHSSNRPFRGPSRYRITPPRVNLSLHRRRRGLCRREARHLRRICRFFECGGVISRRAIVVTDNNFLQSHLTSSLTMSLKMYNEQKFMVYAARRADRFEYAEQDERKFSGYAQAHFHRSMVNSRKETDKLLHRFVVWSKYNEIYQAHKDRAGEGSPANKKGGIEDSGDYAEGECTMDATDTYEGMEEATDDFASADVEFDNPITVDAADMGSSAESADSDSDMRAGPKPSSGFTIPAAENLCMLTINISKMLNCKARVVNVSQSLTRSEQLKGIMERKLQADEADEPVPLNCSHQEFLYVLQRLNPTVVVVCRPNIKVFRVIEQHCALMAAAGQRVCLRVHVLSYRDCIESHKFARDLKHELGCWKDIQQELKTLQVTFDESVLLSNVNGPPQLAVPEKLAVSQSPVTTPSPLNTPEKAQALVPVTAQATGGVDNSDATKLAIATTQTSALLADMLQPPIQNARPAAQVVIDMREFNSKLPFHLYYKGVQLQPMMLEMGDYLLTRDICVERKSLSDLVTSLGSGRLAQQAEELCSVYDLPFLLLEFDDAESFHLSPCNDQSTGINYIYSKLCILCCNYPKLRLIWSQSPESSAAIFVALKRGRGEPDAAANSMLISQARCGTKGGDGSGQAIVERRRPEDVNNRDALRILRKIPGVTSYNVSEILSRVTSLRHLSEMEEADLCQFLPEANAHAIYNFFNQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D637</accession>
    <name>A0A061D637_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768352.1">
        <property type="nucleotide sequence ID" value="XM_012912898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D637"/>
    <dbReference type="STRING" id="5866.A0A061D637"/>
    <dbReference type="GeneID" id="24564707"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300710"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1168" mass="130368" checksum="28AA2343DECF4E30" modified="2014-09-03" version="1">MATANKVPLKTLKDCFQFLEWLKSNGDMQTQVASELETRLRDKYNGVNGKQIENSLSQFLQLVSKFYKKLVTDEVLQKAQSTTNKKYNRSVTLVVFKALLECIPKVLSACYFLQYHVDGNFKTLGGGEWAGDMVGRIAQSGSGLGKIYSYLLIKSSNSYRVIPGGFVQGELNEGDQNGGNQNGGDQNGYKHGNVMADDLGKILEQRKDNLFLDVFVTSVSSTAGTQASNTANVLALLKHFCEIVQNDLDDKLKKYLGSHNVCVNWDKLTPHCADLKTQLDKLFANDRFSQTGQLPTLYKLNKEEFVKKMARWLKDNLDKVRGKLHNINKYSHMLDSINTDKVGDYLNKHFFPYGFTFDAKDFGKDNLCQVLKDDWKGVIEMLDGHDTGLAKLVDILKDMKCTQNQDQTADLEDDDEEEDYEEVVLEDEDESVISSNQNDGQSGQNPESSQEVIGSETPPEDGKGQGPTGSPGDAGKSLQVGGPPAQQPVPPPAAPTSSTITPRPGSSSSGGLAPGSGQQTPMVELGVSIPSWQNSENAHKLSDYALSDDDFERLLYPNGVNLGKGPLIDPKTFGKAHPQSGIVSYNEKPEETSEKLSKSLGLHNTYEPLKPLDFTFTPYYEIAGDPYSPQCRNPWYIHNLSTDPASATLSHIPDSDHLPPPKTVREMLYWLVGLNQHGYIRWVTECIKSLIEEYNTDAPQSPYAIDIAGDLTKLDASMVTRTLTEASLYAANVLYTVKYRDYYTVYNDFKFESEYSKFRYSSDPISLLCQLRDYAYAGHYQLQFLKTQCARDKLSGGWMGCHFGQDVAADSPLQAFLTDAYDSMFKTHLFDPCNICLKSRVKMGFKHKDLPKPSQTGNTLFTVLSPSCGDDDPLLTLSSYLNCLTRRTPRTTGELVSFFHNFGVELHDDYQKALSSLGSSLSTPHPNCPEWDCLRGTDLQAVRGIRGTDAFNTIHDNAHPNSLSTLFGCDITNVQCTKLLSPITYRAYSLYSPTFAHTYLIWAVYLPDRLWESLKKLRYDLEGHGNTKCASLHSCPYAMPLLYLHGFTPPEGTPQTSLTCSELITKLGEVVNGGPMAKLMTCMDQFLYRVRKPFIYTLIALWSAAALLLSYTILYRLDVLYLCSHAIRSKASHLIDVKALLTNSRKMLSLYDADYFDDDPNDLVDQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6A3</accession>
    <name>A0A061D6A3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUMO-1-ACTIVATING ENZYME E1A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768407.1">
        <property type="nucleotide sequence ID" value="XM_012912953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6A3"/>
    <dbReference type="STRING" id="5866.A0A061D6A3"/>
    <dbReference type="GeneID" id="24564762"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301260"/>
    <dbReference type="OMA" id="IVCAMES"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="34"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="357" mass="40716" checksum="B872317B9F9165E3" modified="2014-09-03" version="1">MANILHCNNKVDAIHTMKRVVCGSSLSNQDALLYDRQIRLWGIEAQQRMMSAQVLFLGKNGIQEEAMKNLVLSGVGVTLANDLYVNEEDVKYSFLLRKSDIGTNHAKSLVYRLREMTAEKRRINFITDSVVKDEYLNGVHSYKIDESIIEEFEIVSFAAESYTLPKMTHVNDVCRQKGVAVIASMDNGMHGFLLQDLNTHTVYPLLLLHHLSVLQPRFPRNCDISIRNVIGYLLMQRLFPHRQDISLESPSFMIQLRDICDSVGGREADIMWVCSHSIHVSDPCFFRVCYILWTITVVYSIRSSLYEMRGKRLAITSGILGGYLALEIRKFITKQHETIPSLCVFDMARSIVTTAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6W5</accession>
    <name>A0A061D6W5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0109720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766860.1">
        <property type="nucleotide sequence ID" value="XM_012911406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6W5"/>
    <dbReference type="STRING" id="5866.A0A061D6W5"/>
    <dbReference type="GeneID" id="24563215"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109720"/>
    <dbReference type="OMA" id="DSLINWD"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF3">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [FE] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="89"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="199" mass="22386" checksum="36E4DE0E128DFDAD" modified="2014-09-03" version="1">MAFKLPALPYGLKDLLPHISEETLSFHYGKHHAGYVAKLNGLVKGTPLESCSLEELVVGQSGAIFNNAAQIWNHTFYWNSMGPNCGGEPTGPIRKKIEEKFGSFSAFKQDFSNLLAGHFGSGWGWLVLKDDGSTDIVQTHDAGSPLKEKLGRPLLCCDVWEHAYYIDYKNDRASYINSWWNLVNWDFANKNLEAPFKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D700</accession>
    <name>A0A061D700_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768672.1">
        <property type="nucleotide sequence ID" value="XM_012913218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D700"/>
    <dbReference type="GeneID" id="24565027"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303900"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7633" checksum="1E8945079BFC717A" modified="2014-09-03" version="1">MESAMPNSGVSQGQEHTLPEDSIVNSIERLHNRGERDCQRIQPVGYGAYKKRKCKDVVEGMKRRAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D722</accession>
    <name>A0A061D722_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768697.1">
        <property type="nucleotide sequence ID" value="XM_012913243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D722"/>
    <dbReference type="GeneID" id="24565052"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304150"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7578" checksum="F863A998CB862BB6" modified="2014-09-03" version="1">MRSSVKRFYVEIDGGSGRAYYVEWLDAWVVVVQIPHPVERPDAEVDHDADDEDDEGDDGDDVRGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7G1</accession>
    <name>A0A061D7G1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">rRNA-processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0303870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768669.1">
        <property type="nucleotide sequence ID" value="XM_012913215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7G1"/>
    <dbReference type="STRING" id="5866.A0A061D7G1"/>
    <dbReference type="GeneID" id="24565024"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303870"/>
    <dbReference type="OMA" id="CCMQALY"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08553">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="258" mass="29012" checksum="54C425A4586F1122" modified="2014-09-03" version="1">MKGSKNKRIKRTLDFYRQLYDLTEPYRVLVDGSFAYAALKHRIHVKDKITELLGGTTHTYVTNCILNELRDMGEEMSGASLSLKRYQRLNCTHGSSDKGANSRRCITSAVSSGNSQKLFVATQDQSLIGWLRKSGDVPIVKLNNNVMFLEHPAKSSKEYKEFVEKGKLLPKDWEKPYLPVLSDASYAPVKRKKKKTKNPNPLSCLKPKRKAAKPQQTSKPTIADASTEHQEPRKRKRRRKGKSGAESSEAGGETSVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H1</accession>
    <name>A0A061D7H1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768679.1">
        <property type="nucleotide sequence ID" value="XM_012913225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7H1"/>
    <dbReference type="GeneID" id="24565034"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303970"/>
    <dbReference type="OMA" id="QKCVAWI"/>
    <dbReference type="OrthoDB" id="359886at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37866" checksum="5986487C3BB6E4C1" modified="2014-09-03" version="1">MDPECDPSLGDAAADSTFKVNRDSVIISLAQAHRSARSSNVVYQEPLETDRGEYYDEWLQKCVAWIAYTHGIRRLDCYSIEFLANFVANEIRRIGRKAATLSRTRGCDSSNFVDVVSALESMNPSLYNMIFKEKVVSAAKQLPKQVVALSHTSFIQPAVLAQPSSLYFECMVNASSHLSEINTPGDSMEGGVASEEPVYNSLSKPSQAALSVNKDEAAVDLEYFITSAARDTYSLKSDEAYQKIVASRPRFAHKHFPLLPAAFKLNDPEPNELNYRVDAQGNPNERLARQNVLLQMELPQLHRVQIRPGLQEMRDEAAAAKNKDTTPKTAEKTASAEPSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N1</accession>
    <name>A0A061D7N1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0306050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768887.1">
        <property type="nucleotide sequence ID" value="XM_012913433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7N1"/>
    <dbReference type="GeneID" id="24565242"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306050"/>
    <dbReference type="OMA" id="NIFRQMP"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="447" mass="49886" checksum="092A4DB1B9A22D3F" modified="2014-09-03" version="1">MGSQFEWRVERVDSDEFRSSRTDISDRLDSGEFSSAVTVRAGSDEYTLTTARPTLSESYSSLPPDGSVSDLRSESISSRKYAKSEDSDSSVVDHDIAMPGQPPAFFDGSRRRQPPSKIIITLGVRDVLGYPVLRLSRYVAVMQHKKSVVDHSASSNGVYRNLFYISSWFAFTSPTGFTLTAELVKSVWRRHGIWGFFHGFPAYACHKLLCDLATFIVPRYIAPQLEAGALGAYKSVFTFGHGSLSHLRDRYAGVWRSSSVESGYESDNSQPSTWNMNPITGFLSRNIEFDAYEFSQHALVELLTYPMLTVSSRAMIYDVAAPMNSISLVKDSIAHEGALSLYRGFFWRLLALLLEDMQKHSAGKPRPFDVIADDSRTDLDNIVPVFLTFGSSICHQMSLVERCMSSVDGFCVEASTASTLSKFPWANITVQMALTFCLLNLRDRLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7W7</accession>
    <name>A0A061D7W7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily C member 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endoplasmic reticulum DNA J domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0306800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an important role in regulating the size of autophagosomes during the formation process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768962.1">
        <property type="nucleotide sequence ID" value="XM_012913508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7W7"/>
    <dbReference type="STRING" id="5866.A0A061D7W7"/>
    <dbReference type="GeneID" id="24565317"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306800"/>
    <dbReference type="OMA" id="FFISYND"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052842">
        <property type="entry name" value="ER_Co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_102, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184">
        <property type="entry name" value="DNAJ PROTEIN ERDJ3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="547" mass="60920" checksum="5FF76712082704AC" modified="2014-09-03" version="1">MESGVRKTRIPCRGRVLFIAIWCLARVSLVGAKDYYRLLGVSRNATDAEIAKAYRLKAKQLHPDVAPGKEEEFKDINTAYEVLKDAEKRQLYDTYGEAGLNGGGAQTQGHQGYDFFRQGGHGHHGKHSGFTFDMNGGFFEDIFENFAFGGGRQHYGGSHGHHGGRGAGGGGGQRMFKGTLVEDVDAAGFKASMSTIRTLNLYVFYMDDCPHCRDAKQPISDFATKFQGAIRVYAVNCNRHNDVCVRNRVEKVPQIVAFAEPNKPVFYDKRTYAEQLDAFVSQALPAEFTIITNRMDLDEFVFQESKLLKVVAIIKRGVYLTKLKALAKDLRDKVTFAFIRGSNKEMVQVFGTRGATTTGVLIPVEDPETLTGKTIDMGALGYHDVVLRLNLAQFEAKRSQGVHGNDTNYSQLTARKMANGECTASDNQFCFVFVKYGKSSEDEIHEALRGLARKYGNDPIKVRFVNAQEEARFVEAFGMSPSCPFYQNCAKLVAYRGKRRKYEILDGGLTVENVEQFINNVISGALTLKQTLTHVPTVNDPNQHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D802</accession>
    <name>A0A061D802_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HORMA domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767240.1">
        <property type="nucleotide sequence ID" value="XM_012911786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D802"/>
    <dbReference type="STRING" id="5866.A0A061D802"/>
    <dbReference type="GeneID" id="24563595"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202110"/>
    <dbReference type="OMA" id="RYMSMKL"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="7"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="416" mass="44961" checksum="CDD133841373E5AB" modified="2014-09-03" version="1">MSTISSQESANVLRNFVKVGVSSIAYLRNLFAESVFEDTVIGGLQLKRLTRSVPESAALLDWIDDGVFDAMGREYLKHLVVSIHNSEHLALETYTFSLQYGSDEDSCDGVRSEYSVQMSVGHGPLADCATAAGGNSGGRVTNGVSNPANLDNASEASSNSTAPLATAHAANTLTTSARPGCLVVSADKEEVKRQTVKVLRDLVLLAQSLSPLPDNRYLSMRLMYYDERVPVDYEPQHFRSASAESFGEAELSLEQQVGALETGHHNLAVDVRSVCYVDENVTNYKSSVRPFDTLTRRTSISCAKPAEPPQIRDPAADLSRQPSEAGASHVRLPAGSSGRGNGVQVPAPRPPVGGRNVMLGLLKRSYELAARTKFISKECLTDAMGVDATTSKALLKNRMIEHGYIDSRFIKGKGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D804</accession>
    <name>A0A061D804_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768318.1">
        <property type="nucleotide sequence ID" value="XM_012912864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D804"/>
    <dbReference type="GeneID" id="24564673"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300370"/>
    <dbReference type="OMA" id="GNRQGYI"/>
    <dbReference type="OrthoDB" id="364384at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600136" evidence="1">
        <location>
            <begin position="29"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="524" mass="58046" checksum="B83E6CA8A5D62F09" modified="2014-09-03" version="1">MRYGVLPYIGVLVLSGCFCVSTLRKVGGDYIDHSLNGDTSAMPRSNLVSRIRDTKERNCSLVSCIGASSWPQRKALHDAFGIDAAKSAALGGPLRPRADLWELKQPDRCTLVVDVDIPAATNDLGRGLDRQPLLRLCQRSGAVVVHLNRSDIRRGGKSFHLSRAARTLLKDLSKLVDTKRGPTVYIFIPDLDTIKPGSSAEDVSAYEQFKVHLSDIVHKSPKFIFKSCGEEESVYRSISQSETPCNPSGRSTSTRKIGTTDIATAISMVQGANEIATTLAQIHEACFASHHTYVKDRLGELYKGTPKSNLTSIMQSSMIDAILSFFLRTRNMTHDDIVSRYVDQEYKRLSLFANDAYLRIVLMAASSAKEQLRNELGKDPKQDAEALVNRIIADHDRKIADAMASLSNKMPLPTWVEETIGDARDQLREKLEAIVSVHTGLPKPTMNHAKRKKKRGMNFTLGLSCMLREHGYGNRQGYINYQLGPLLLTVGYANDRDVAEAKPGTGILTPAFRLQPRLHVNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D807</accession>
    <name>A0A061D807_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766026.1">
        <property type="nucleotide sequence ID" value="XM_012910572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D807"/>
    <dbReference type="GeneID" id="24562381"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101690"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="263" mass="28108" checksum="BDB78968547EB998" modified="2014-09-03" version="1">MAPVSGGDVALPSSIKRASSINEAGLRGDSHTYRTNWDERPSQASSVVDPPALTGATSAVSLEFAKIAARADAWLTAYTTACSVSERVNVFFTGLEVLRSAADARNAAQRNAQQESAALLLESIDSALASLSGILEVASSTTRSYSRLSGYKEQLERYRRFICGAGERVRVRSHSSATTDQIRDICEEVATISKNLQPLSHPGDADASANVSSLCDAYGVYMKRKKQRATRERWALFVGSRDKHTSQQPGSSSGGSSPQGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D830</accession>
    <name>A0A061D830_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0102040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766061.1">
        <property type="nucleotide sequence ID" value="XM_012910607.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D830"/>
    <dbReference type="GeneID" id="24562416"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102040"/>
    <dbReference type="OMA" id="IGPRSHY"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1181"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1467" mass="166333" checksum="60607330038F6662" modified="2014-09-03" version="1">MDQRETGEPTGAARGANRPTLFNLLEVLASDAYTTPQQRHSIRGVVTEFLNNKFEHSKVYSYIGAIVGHDVLHSVIKQLESDPDRVPLPDQNGLMRIESAFNLSRTYKAPTHAELPVTVSASAPAPTAPSMQPSGPTSTHFAGGSKEDILRTIRRNLGTRKAPGNLTANKDTLSAVRAASAGVLLQKACWMPIRRSLSAGALYGHSLVCIGSRAYLLGGSNGNPQGVNFGRAHVVSLVNFSSKPMTFTGEIPPPREGNTANVAVIQQSHSVIVFGGFNGERFFNDIHILDLEKRKWMHRRHAAGRVPLPRDEHCAVVYPARCESSQKPKSGAEFLFIFGGKTGLRTQLECLNDMWAYHIDSATWAQVEYPADTKVPAPRFGVCALWADDDVLCVFGGETHGPDGYVDRSERTLLDDLWMFKFSSPTSGTWYQEIYEGSIGPRSHYSSIFIAQRCKELHTGVPRTIERLMLLTGGLTYAPGSKKTVVASDKLYFYFFSQRRWYILKPNYPRNFVGEPFEPRQLHVACFFEKRNILFPGSKPSVPCIFFHGGFHRKQVLSDAWVLSLTGEDLFLSNSVISPSDSSQLKALQTKDRIFPPWYYRESHSPDMLWALCSMQRWAFGGIAHLIANSLKEATSSTRITIKWEQAPQGDRALLSIQDDGNGLDYSAMNKLLKLFGQSKTGERGQAYEYGVGFKMAFARTASGCAVMSRTTDTIGIGMLSVELMSQCESREMSVPLCMWRLPSKELINKEGSRMVDQRHHQRLLMSYSPFNTATLLAEQINMLGTSPGTRMLFWQMRDDMDCVWYSPKDHTLMLKNPLYDDLEISSDEIEAPPPKVSPSWLEVFPLWRSAQYSMDYCLPVYIFWLHLRSSCAISIQDIDLVPYDMRDKVAQAAEAANASSEELTTEDECMVTSAQPMSVQQFQVQPLQDHPLQAQLQAHPMPLQQFQVQPLQDHPLQAQLQAHPMPLQQFQVQPLQAHHLQAHLQAEQHQDQPLLAHHLQAEHHQDQPLLVHHLQDEQHQEQHLLSHPLQAEQHQDQPLLAHHLQAEHHQDQPLLAHHLQAEHHQEQHLLAHPLQAHPLQARQLQAQQHQEQHLLAHPLQAQRHQAHQLQAFQEAAHQLQAQQLQAQQLPAHQLQANQEPKHLLQTHQEPKHLLQAHQEPAHQLQAQKLQVQQLQVQPMPPLKRHHPLPQQMQHPSQQLQEQEEPSEPARKEVYNCQSTGCTYCGVAPVDRGLCDDRSLWSFLRRRLFCRVQLPYLFAPSDHKHGCCAMIGFLNRPHFCGPEDVEEVTCDVSGERVCETGVLLYFRGRLISRLEGHFPAPTSEIESAREPPKESLFKGELYRFALTAVVNVPEWLIPSATKQEFVQENNKAFFDFKSKLMGLISEYSKVCSNRAERKAWESHRLQQLIAYDQRQEQLRIERTISDQNEETLPIWRNEADREMAPGDLAEVPALINQEPLRPYEHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I3</accession>
    <name>A0A061D8I3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767410.1">
        <property type="nucleotide sequence ID" value="XM_012911956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I3"/>
    <dbReference type="STRING" id="5866.A0A061D8I3"/>
    <dbReference type="GeneID" id="24563765"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203820"/>
    <dbReference type="OMA" id="DNTSEMY"/>
    <dbReference type="OrthoDB" id="1295045at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF39">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="37"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="254" mass="29233" checksum="A05CCDB3641CA867" modified="2014-09-03" version="1">MVENMSNSTPNDLTATEPLSPELSSIVRCYKNGIPFEGWNYVRDYHFDNMTMHLYSRCRGSSTLKEFLVHGDIDVCKEKLIELILMMKQRSEWDETYVEHKVLRPLENGTDVVFTVSKYPFPLAKRLYTIKRSLYGSMDDVVVLATKVIPYDCPNTIRWSTRVDDFDSNLIVGDIKGKPDHCHMIATLYEDPKVILPNMYLNIIIETLVPRILRKMIAACKQYCNDDSKELCRQLVCIPLDYKGESPSATENSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8N6</accession>
    <name>A0A061D8N6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769079.1">
        <property type="nucleotide sequence ID" value="XM_012913625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8N6"/>
    <dbReference type="GeneID" id="24565434"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307970"/>
    <dbReference type="OMA" id="MMQIMTE"/>
    <dbReference type="OrthoDB" id="360858at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595570" evidence="2">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="387" mass="44827" checksum="7316EBBD4E36DC0A" modified="2014-09-03" version="1">MNPCNSVLRVLILACALWARNPRADCLLHTAFVPHLDASLPRRCGRYLGSTASGELSSSPPAGNPAGMGKKKNLFKHQFDDYADVGASTAIKKDEERWQDIVMEEIAKNRNVEPSDNFLFGEYNADEYVLGKTTHNVSAMRKPSYNYRLSPEGRVKLENRIIHLKHMAATNPGTPKAVRPKLWIVRPSCGNYCELLERDDERLRSFVKRVRKHFPKERLEILKVKIDVKMPLCEVFFEGDITDMVRIFYARGGTLQFYVVPRFWSRCPLLEKDPRLEAKYGKSTAPGLFPQWDEDGMLEELMDCMDVRPDYALEFRLPNAWQLLPMVPEHDRALMVSLFEKVHWPTRLRVQNAFEQGIEDYRDVISDEYAELQRLDRGRSNILDYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S0</accession>
    <name>A0A061D8S0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein KIAA0195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769297.1">
        <property type="nucleotide sequence ID" value="XM_012913843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565652"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310140"/>
    <dbReference type="OMA" id="ETNWNTS"/>
    <dbReference type="OrthoDB" id="5568754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1313" mass="147451" checksum="C275F5B7F7BBF58E" modified="2014-09-03" version="1">MSDPICDMTAMLSCSLFFMCNSNTRRTTEMANVPPTYESLQKHETDADGRSYVESLFRKDLCFGTVAIIGVLTLVAQKNSARIPCVIYFVLLTGWLALNAFVKLTMKRIRRSRVGERVKDILNSFRNDIGSTFHSELEQKRFSFDPPNSVLIPVYRNREWKRLPTNVLVSGDVFKMKPGEVFPCDCRIILRCDVDGNVVLGDEVFEFGSVCGSVGEPKPNVEFIDGTFVAESDAMLPQLKAFLDTKLYGNPLVNRGCERNVFEAPFESTGGSCKNSVWDLSDSTHFSRMHITNIEMSVYLLLTAVVALAHGWLNGIKEWTSSLFVGSTLLICFAFPGFEPLVQLADIWGNVKLQTLFNWHNEKRLTVDICPQLSSSSSSTFIGGSKAGSVDSDMDANQIPLVNHLKELNKVMKRGLDSAGSLIHVLSSVTLLCFVDDVGLLTEGCATLQEIALIKGNDIERSNTVRSNGDSPFKTMNSTSSLKMKSSIESDDSGCVSVKKGESYRECATCGISSTGHEHLVILDVYSDSSQFGKQYVRFNNEDERGCLPQLLPLSFAMTVTQFPRYQPPSLFRLPPELIYTYIGMLSNESFCDFTDCLCTFTGSIGLKRSFSRRFRLMRFVMLIDEAHGPNGMLLLFFLRDPRKQIVQMFAKGKLDMLLERNLNYHNHQQGKILAVNRLMKRKLKELNMQWVSSGMVSFAYAYKPIHLEEFNMLMAHLDSTTVFTVKTGKSEGRRKRKYMYLEGATPISMQLGGECIYSWFKQFKKQDKSEASEPWDTIPKSTKKRILKGYLADMVSACLKNTVLLGMSADKRLYPKEVPSRIQSFHDAGVRFVYFSKHDERQTRVTGAHLGLETSWNSMISLANSERSTYINQDGNVVLPSGIENIKRHIEEVDDIPLQVSLFANCNPKNTAEMLGILRNNGETIMCIGGGLRPSNFYVFREAHSSVSVAQGYHPVCRFCRGKRWSGVARAHMFDEALPEMKLSAALTSLPCDLQTSTMYKVADPYYVMEMLYEVLRVARHVSTNIQESAAFMKLACHSLAWLLFLQACTGFADFIQPLDFALTLCAYVPMVSISLLANPPDDKIMQTLPNKIHKDDLKVKGKSMLRNYSRLFLATTLTALGYCLCLFIINKTVAAELASVGVSMDIGTCDSPFRMPLRQCVHKVRDALTAHRQTLGEDKVIVHPDTPHVLAQLCASVLLVFNLATASSSWVNKYGHGSKWPWHNTNWMFTSFAVVFCHIALAALRIGISHISSKEVALLFPLQVIGFGPGLALMIVIFDQLIKLQLRRERNIEQKFLELLFSTRLGMWSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Y4</accession>
    <name>A0A061D8Y4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769352.1">
        <property type="nucleotide sequence ID" value="XM_012913898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Y4"/>
    <dbReference type="STRING" id="5866.A0A061D8Y4"/>
    <dbReference type="GeneID" id="24565707"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310690"/>
    <dbReference type="OMA" id="EWEADAI"/>
    <dbReference type="OrthoDB" id="361087at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="415" mass="47036" checksum="A2D9DB8D0CA0FC47" modified="2014-09-03" version="1">MCSAFSEVVAARRKAAARVGHTHRAKHTPQDKNRNKEYLFGVISADDVEWAKNALDDSAQVKRYTGREQDQDRVSTAESETIPALDGPNDECVQSKHTSIKDLVENVQQLSLKLGAEGRQRESLEQQVEQLREQNRQLMSQMETAESNSEAANAYAAALEAIKTLDVKEFGQNCEQIMDAIYSVICDAFGPDNNLALLFEEMADIYLKAESKHELEIQAMQKQIDFLTQFENVIKGEVKPNAKTLDSLVEQLKATKEESAAETSALRKQIEYLKSENQRLQKQKKTVEQNFEAEKQDLNGIIKAHQDRYQQLLQDQAQLLSQMPLLKLTPTDRPAEDGVLRQSGTNTLEALVTALYRKDAETQKLVKRKDDVIQQQQSTINKLEARLKEWEADAILWLDYVNQSNAKKKAALKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z7</accession>
    <name>A0A061D8Z7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767545.1">
        <property type="nucleotide sequence ID" value="XM_012912091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Z7"/>
    <dbReference type="GeneID" id="24563900"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205170"/>
    <dbReference type="OMA" id="VECEIRY"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="407" mass="46684" checksum="7AE9B0150EB2F77A" modified="2014-09-03" version="1">MDCARCVKLFCYAIIIPFLSLKHDFVKCSASEQCLENVLSIENETVGSSNYESVKQLEEYSIRRCPFNRFTEKPSERGDDVIITDNRRMRDVWWIASLPSLGPNVTLLNEIAKDEHTQCDVKGDRNQEHSKCIRSHYRIDLSTYHSLGHEDYGNNRVWNGIFRRAAKTMFPSYIRISGRSAHSTQYEHMAAKLYGYKDFELASIFLFLSEGFRKAIKGKAKIKFMERIVECEIRYRNADLVKKKLTTYNSKHFGRTNKDVPLLPFFIIPKGTFDDLLKDTPPADHNIMDIVYGHKELIKNTAKIEFNALANNLANFMINNAHISVDQIETFYIAELCSCNTAYMLNDLVKSNVRDKTLRYMAIITLLNPNSMNIATTILKIVVIAVAASISAFCTAIHYLIQHTPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D926</accession>
    <name>A0A061D926_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dullard-like phosphatase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769387.1">
        <property type="nucleotide sequence ID" value="XM_012913933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D926"/>
    <dbReference type="STRING" id="5866.A0A061D926"/>
    <dbReference type="GeneID" id="24565742"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311040"/>
    <dbReference type="OMA" id="DVIDCER"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000093">
        <property type="entry name" value="NLI interacting factor-like phosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="87"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="284" mass="32329" checksum="3A130DF1A0C34592" modified="2014-09-03" version="1">MIVKNLVGTEVKAMGVKPSRRDYLRRILASMRLTAGISKLKISGGRCCKLVDSNTAQGGQQDQNHSCDGKCDAKSGAPLKSPVLRVDNPRKKTLVLDLDETLVHSSFENKGGHDVTLSLQGENKSRHVYVNLRPFAREFVSAATRMFEVVIFTAATQDYANPVIDVIDCERRIRGRLFREYCTHWNGCYIKDLDIFDRDPKDIVIIDNTPVSYYLQPNNAIPVSSWHDNRNDRELVQLLPFLRKLSTASDVVPLLNERYPSNELNSDISRRRVQFDHLFPVQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D945</accession>
    <name>A0A061D945_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0304060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768688.1">
        <property type="nucleotide sequence ID" value="XM_012913234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D945"/>
    <dbReference type="STRING" id="5866.A0A061D945"/>
    <dbReference type="GeneID" id="24565043"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304060"/>
    <dbReference type="OMA" id="TDFYRPP"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="8">
        <location>
            <begin position="139"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="303" mass="33555" checksum="F52BB5BF633DFC5A" modified="2014-09-03" version="1">MASSDAVADNVLLMLTEKCSGIDGLLDTFFSFLGRRTDFYTPPGGEDPNGHLEYCVKLVSQRCRQAGAAAIEAKRREADSKRQKEAAKHVVQADNSVIDVTSGDPESVIEIPRNQEPPEEVEEHSEGETDETPPPGNGGTTEWYVWTQTLAGVEVSAPVPAGTKSRNIKVDITTNRLTAYLNGSLLFGGDLHETVRSDDCFWTLVDGKTLQITLEKRNQIQWWPCVIKGHPEIDVKKIVPENSKLSDLDPETRHTVEKMMFDQRQKAAGLPTSAQASQFEALERFKKAHPELDFSKAKINFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D972</accession>
    <name>A0A061D972_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769279.1">
        <property type="nucleotide sequence ID" value="XM_012913825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D972"/>
    <dbReference type="GeneID" id="24565634"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309960"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="85" mass="9760" checksum="58E9226A6D5A8E3C" modified="2014-09-03" version="1">MTWEVIVTKEHSKYRRDLGISDRMEAHIQRVVIQETHKIVMRDMKPKEDYDSVEDPQAQTGWTPAWMAPVTSGNGPAWIPQPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D998</accession>
    <name>A0A061D998_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766471.1">
        <property type="nucleotide sequence ID" value="XM_012911017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D998"/>
    <dbReference type="GeneID" id="24562826"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105940"/>
    <dbReference type="OrthoDB" id="366450at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="701" mass="77838" checksum="14581619F709C653" modified="2014-09-03" version="1">MDDVRMRMEVASDERRPFADIATLDNIGDIQRQGDDALLYVSKNNPQSLLNIVESIKDESFKVEAYDYIDSLENSAPALPCEQLQSLPKKLDEATCMENRHGTTRAIANSSNGVSTPAQITDRSIALDGNTELLSLDATRKTHRVIPTPHQSYMEANEHEAMDIYKSSLAIPKVAPTPPCSIASNGNASSSVGNRSAMGESIDACGRLPQHSSRNQSIDPPWSEPFFIAQPFGTDAGLAESSNCEATILKQMLDGVVEEFDISAQFEGFEDAEILVDCENTPQQCQIRMTCICSSSESYDDDESPHDRTTVKKKNPTKDGCKHVPEATEYDAEKNRSKERCTGTGATKVCKQCSGFDEAPDCESLTNKKQNNHYAGAEMMYEGEANENADDHREPTPRGGDHNKCMERAHEPRRAVHPHCHHSSIPDSVEQCNCLGYMSFGSRECEKPNSADCILEANVTGDGARIVATDPKKNRSPDLVIRRLKSDCHECRPRTSKGYCNRCCSLQVTAEDRLGSFNEVYPDSTLVDNGFWGLSGNQEPGGSNAEFSVPDLPMFNLFATSVRQPCENLEADTSYGRKNSNVSPHIYGELPRERVLFYGYHGPNCQYVRTTQHPNFRHTQACTVNPRELGFDSSESLNASLNAKCEIIVRPPQCLGGPVFFRENVAKSFLCQQDYIANTVFQIDWQNNIHRKKRSASCWQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9F8</accession>
    <name>A0A061D9F8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769369.1">
        <property type="nucleotide sequence ID" value="XM_012913915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9F8"/>
    <dbReference type="GeneID" id="24565724"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310860"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="105" mass="11920" checksum="CE4472901407B96B" modified="2014-09-03" version="1">MGWRLQRLRGVEGEREDGERGSVGSAKCIECVMFCMIRLKSKECPPSGCDTQCRGRENTCECQPTTDSSTAPYIIAAVALIILVICVMIYFRVRPFHRVRYLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9G1</accession>
    <name>A0A061D9G1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768818.1">
        <property type="nucleotide sequence ID" value="XM_012913364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565173"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305350"/>
    <dbReference type="OMA" id="LNPYNPW"/>
    <dbReference type="OrthoDB" id="361045at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1451" mass="163975" checksum="26B31FA8A0DDD4CC" modified="2014-09-03" version="1">MAASYTPTSSDCEIQGENGDNDFEDDGRGSYNDSDGVHAMDDNMEGNVLGGQKGKLHSSNRHELLEDDNFIPPIIKSYRGSMKTPATIRSNAKDGKIAKGIRRAGLEGESKIREDVTGKRFGVAHVDRISDDLASKDPSDNQNDVNGDEDGESVAYVRKEGTSIGEEVEQYEDLYTTMESWGRSDKKGDRDVYRFLKRRLKDVQQSAEVQYAEDADGMTVDDFLEAIDGLQYEIEDHPDLPYKWHRYMEIIKSGYDDKIRAARRSKQLTASDVVDKCLRQLKREEACGYRYPITGTPDETYSDPNVYKAWGRTSLHQTQYLKRPSTTCGEVEERNHTLEELIISNSLLKDMDEIEKQLEEIRHKRLEKEIGHIESVNAETCINSLPEAIDNTTTDSTTTTTESVECRSIGSLSDTNVEIKSENDIREESATATDGHNVGNDDIQALPRVAATTFTATIDGEYKLVDTDFLRSERQRQLELLLSLNPYNPWDEYRRMTRIKSGLQLKEPIEVNYKLNTVDLKVKFDSSANTGVGAEDNSTDPLLSRESTGDTTDNIPSQGDIMQMDGRQTNVEGVATELTATTNNEQTNHNVQLPPNFLQDYLHHFLMLPEDHQMMQVFEKAEYLYDVLRYFDPFDREEPKPEPEIPDAHDRLFGIIFPGWEGFPKPPPDPVYPLTLTPDKSPETYRVNAINAMVALLKAKQLLLTPAADLFQEQRVKAILTSIERSLELEITRLKLRIADIEVPGIDAQLCKVDDAYLATLSATLAFWNVRDGIETIVDEIIVLTTAKMAQMRPKYLIPIAVNLANVHKLPKSVFLKFVKAVAQHVQHHMAADLVKCAVDVDHPKCMDFDTGAQCLNLLARYPGALTRDFMVAFMQLYKRDIMQLKVPDFKGNKDIMVTSALHEPESGFACAEGYLSQNAPRKEGDNGDPGTQLECAKSSASTSNPQGPCDVNVTSNDDNGVGLVVGPQYWEYLRQAVDEEMAAVHRRQDKRAHQLKHALNVRGIRGRVVQHIWSLLSCLSWCDLIKEYKHVVDTFDMESVLQDFELSSVGALAVLQTCSHKTDKERVLIGKALSALRDARAMISDEAWLEAMEIYRDATNTGPEGAEPRIEPDSAFIAAMMNRFVENRQPSWQILRRTVDLLSDFSSVLSKNQRQELFSQMCEAVCDYAHLQLQALNAERLDYPLREMAHVLRVSATCGVRIDNVWKIFLDLLKFFKHTLSVKDIKETLLALKAAKYTSLSDVGDLLIRRMCDIVEVMPYTSPDTLCDIMELALSIKIDPTKLLRWFLYLKFHDIPERDMDRLAMDMVGEKLDYEVDFRGWKRPVGKGTPGERLRLFNNLFAPYKMHGSKAYYPSGELKYVMQQSIRDPPPYSGKIKPKSGVQLPRHLSERLKYIIQQMTDSGYEYAQADIELFKLAGVMPQKAGSATTPANTSIGAIGTQYYKDSDIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9H1</accession>
    <name>A0A061D9H1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769379.1">
        <property type="nucleotide sequence ID" value="XM_012913925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9H1"/>
    <dbReference type="GeneID" id="24565734"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310960"/>
    <dbReference type="OrthoDB" id="365713at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="122" mass="14112" checksum="EA0E5A23960ACCFC" modified="2014-09-03" version="1">MSKKNNRTVIKKRYDVVKKQMVDQERKRQERNNLKKLCRGVNLQVYFFLVHYTTVQLSSFSLGQSSQHTSSAPLEDVVMKDTKPGVRGTNFCRVVSGGQMITARRKKVLKQALKRQRKLNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9H3</accession>
    <name>A0A061D9H3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0106740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766551.1">
        <property type="nucleotide sequence ID" value="XM_012911097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9H3"/>
    <dbReference type="STRING" id="5866.A0A061D9H3"/>
    <dbReference type="GeneID" id="24562906"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106740"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="499" mass="55160" checksum="91FC0A12148E026B" modified="2014-09-03" version="1">MVLAELGGQISEAFRKLHARTVITDEVIDEVIGDIVRALLTADVNVKLVRKLRENVKLQARLHADALGANKRKFIQKAVIEEFISMLSSDREPYTPKKGQPNVIMFVGLQGAGKTTTCTKFAYHYQRKGWRTALICADTFRAGAFDQLKQNAAKVKIPFFGSYSEANAVRVAAEGVAKFKEEKYDIIIVDTSGRHKQEESLFEEMRLIHQAVKPDDVIFVMDSHIGQACYDQAAAFNKAVDVGSVIITKLDGHARGGGALAAVAATDSPIIFIGHGEHFDAFEKFDAKSFVSRILGMGDINGLINTIQEVVNLEDNKEMVGRITAGKFSIRDMYDQFQNLLKMGPLSQVMSMFPGIAPGLIDAGSEQQGVSRVKRFLYIMDSMTDEELDCVKPLTESRVARIARGSGCSVFEVNVLLDNHKMLQKMVGNMGKAGLNKESAVHSMMRNPQQMMSRLQHMIDPKLLQRMGGAGNLFKFMKELSQNENVAGMMKQMGGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L8</accession>
    <name>A0A061D9L8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766606.1">
        <property type="nucleotide sequence ID" value="XM_012911152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L8"/>
    <dbReference type="GeneID" id="24562961"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107290"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="10141" checksum="738520B02FA6BD28" modified="2014-09-03" version="1">MEQVIIDTAKHAEDITKCVKHSAENLDRMIHFAPPLKSTIQNVTKTTIRVKTWNIDQTTRLVQAVRMVQRIFRLKKTIILRVKEACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9N9</accession>
    <name>A0A061D9N9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">26S protease regulatory subunit 7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0107430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766631.1">
        <property type="nucleotide sequence ID" value="XM_012911177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9N9"/>
    <dbReference type="STRING" id="5866.A0A061D9N9"/>
    <dbReference type="GeneID" id="24562986"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107430"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000075">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="200"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="425" mass="47056" checksum="40CB9F4629348349" modified="2014-09-03" version="1">MTAPEEEGESKTASNPLNDAEINILKSYGVGPYTESIKNADKDIKDVVQRVNKLSGIKESDTGLNPPHMWDLMYDQQALQEGMPLQVARCTSIISPGTPQAKYVINVKQIAKFVVGLGEKAAATDIEEGMRVGVDRNKYKIQISLPPRIDPSVTMMTVEEKPDVTYNDVGGCKEQLEKLREVVEMPLLYPERFVSLGIDPPKGVLLYGPPGTGKTLTARAVANRTDACFICVIGSELVQKYVGEGARLVRELFQMARSKKACILFIDEVDAIGGSRGDESANGDHEVQRTMLEIVNQLDGFDARGNIKVLMATNRPDTLDPALLRPGRIDRKIEFGLPDLEGRKHIFKIHAKTMSVEKNIRYELLARLCPSSTGADLRSVCTEAGMYAIRARRKSISEKDFIDAITKVIHGYKKFSATGRYMVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9R4</accession>
    <name>A0A061D9R4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767845.1">
        <property type="nucleotide sequence ID" value="XM_012912391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9R4"/>
    <dbReference type="GeneID" id="24564200"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208130"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="122" mass="14149" checksum="D6FF82A91B03BA73" modified="2014-09-03" version="1">MSDTDTSDKIQHSRRLCDTLPRCQNRLGGNIRLLKIIPLQHESQYLPKYDVQNGYIHTSIITSVCIVVRKMTLIRIREHTVLSAYRITMMRKRQRIEKARSPTHYLGTKGSNGSVQKGNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U3</accession>
    <name>A0A061D9U3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767870.1">
        <property type="nucleotide sequence ID" value="XM_012912416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9U3"/>
    <dbReference type="GeneID" id="24564225"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208380"/>
    <dbReference type="OMA" id="HVQSTHY"/>
    <dbReference type="OrthoDB" id="366157at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="846" mass="93009" checksum="B658D9FA6046E319" modified="2014-09-03" version="1">MRAPLPTAPLTQSLFCLARRWVRHWAKKRHVQSTHYSIGDADSALYRQVVPGDILANRRRLPNRKLRPREFRLAACANGGFRLRAPYPPNVNVTLAPYPRNVAGVQSDRQKMGHIEFPQQYKGVKYVTLKRPVPYPRGSGAYGFDVNRILIPLMPSLLQRTGLLRPLDVWKHVHESATSVSMEVAGHFGRAAPPSADWRARVVPESASSTEDGSARATSALCYQVSEGKADIQALFRRVEFIASNVRSFSVNEVMLLCHVLASHAVSYSTWFRVNCAELTVLTTTCHRHLLANVATMTIEQLHCCLVLFEVMAARYPIFRLEYGRFQQLVMGRLCAASSADAFANDALSVPPPRDDGSSEVAVRKLSSKVQRVYRRVFPYFEAVNIRHGASRANTAHLVEAAACIQRQHASSAFQWGPFNALCANMKQLLRNAELFSLQSTMDFVALLHRNASMSKDAVRLDAEQVHVLAKKLAELNVDSYMVIPKEDGELPLPELVDQCVTKLFAVCLETPPLMCLTDCLLALIENGMLNDHLKLLLLPYVSSCILHHRNRVDDLLLLVPHRWLQPPHWLPFWVVYTSALLSSPRHQNGANIKFLSLMCDAISSYLSGLSTGISGNHAGTASGQPATGPCSAIGTTDEEPSSAAAPHSDALNGVSQGYRWLGQLDEVSLLNITDTEDLDCTSSLPALLEKRFGVPPHQEGVLGGFVASLSALQEVVGTVVQRGSGPADQTSATPSHKQGSRKDDNPGVSLQSSQNGNKNAEKHYAGRLMPDRNVKETDTISLHRGTQPGVASTQAQMALGGADDTRFEPSIASDESAGSLYELRRAHDILCLRISILQRQLDSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9W0</accession>
    <name>A0A061D9W0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769682.1">
        <property type="nucleotide sequence ID" value="XM_012914228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566037"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313980"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1478"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1540" mass="171446" checksum="99A8F86932209562" modified="2014-09-03" version="1">MTSINHSNNLCLVTLRPLSQGSMDLLKHYNPEITDTINTLKSTIGKGLGVSGFAYAIGKVRSGLQGYESGLDAEIEVVKNAFKQLTESIKTAKSEFNKPISKPLTQQLSDASTGGKFITARANNVDEAVKKLDEHLKGMLTYNVKLLLQAVEGFHRVTEDVEVKHFARAMDTALVSQKQKLNGTVNIGITNLQKTLDVEIGKVGDRIKIMGQQKDAQLKLVTEAIDSAVYNVEDLLDAFTECRNDTKELFVRLRNETTEINPTRGDKSNLRLQFDQMAGAGTGIENDYTAKLLSVNGLVEAAVRRAVEFINNVDQSIKSDLIGLKTKTVKNAIEGFVLQLNEAKYEDAAKGIRGVAVSISNLGTLDGTEIRQWLTKTADGLQNVKSLSGQDASEPNQYGRRTLLYSLENLKTARHKNGGSEKSLFTVIGEDIVKEVDKAIGDIETTFSKIMSEYYQLTKKALTQKENGAFRNMINGIKEHVNYTFTHVDGKKVNTKLLGEYETNKSLYDAAKIAMNSIIPMLEKIPSAVDDAQLEADSKIQLLEQQLNLVMKSLKFIESVLRSAAERLHSAIDDIHEALSNASKKFKTAVSQLQSTLLATVSSAFSTLTHQVQSLFAKQKQAEFAALESVVTAQLQEIERVIQADRESGVKGFLSRLKGDVDASGSAVSPNKLDAMITVVGRANQTPKETLGRFAPLASVFKTYADDIFTYIEWQVKTPKKFDTPGQGTLLERNKQSKQVANIKSKIDQLLGHLINHDNKIYNYDTIFCAYLRELINAVGSLTADTFGEGRHPNLLNLLKDAMTHFDKELNYAYVSTYSDRTLFDDDPSKYAKVCLTTLPVLYTELTQLKEGIERTGENWRFYSMYNSSQPRAGLYGVFFRHNGYDVGRDRNIDRGELNNKATMNSNIILRHLATGDHVLFSPAFTQLDGAEGSLENESEPTFDVVHEEGVIPKLYAVIKPYNQISHLSTSFATKTPCSVYEQLIWLSGLQFNTAFGRLLNHVPELFMVPDELNPSRKVLQPINAHTKSVLPAHISDAIEHLSEHAYLLLAGILGTGDANTIYACDFGSNSHKLKYPTSGEECFDMLLDILRRLFTPLKFLMTQCGLSAKHNGWNDCTYGKGIATTNWPCNDHSRDKATCQPKCQANCQPNCRTTSPLMSYLNDCLPGHLPHTLETIGCKSKCLTCPSNKKGMPCITPFGFRAFSGSTRTGAELCDMIAKFLDNEYCTSLFCLAPTPPATLPEHFGFALSIAQNVNPATTVYSKIKTFAGAFESSIKTQSINLYEDPFALTKPIINAYGSDSVKHGECEYYHLRNLTSDSLCKHKANRIGSASFLSPLCSDSYDILANKHSKAYLSWVVYSPWTFWNYLNNLYNEFCNVVCQDWGCRQCMAGDACKRGKHGSEKYSCHCKSIVLCKGVSPTLYRCGFMFADASTLNTKDSVQTCFDFQMKLNKILNSQYFTDLFTECDNFLWTIRTPFSYLVLALWLLSLLYLIHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAGRVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA67</accession>
    <name>A0A061DA67_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L7Ae containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0307510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769033.1">
        <property type="nucleotide sequence ID" value="XM_012913579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA67"/>
    <dbReference type="STRING" id="5866.A0A061DA67"/>
    <dbReference type="GeneID" id="24565388"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307510"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="108" mass="11926" checksum="EE13A6BA8C6209CA" modified="2014-09-03" version="1">MAKKTKSKGMDNMNQKLQLVMKSGKVCLGFKSTRSALRTGKAHMVIISNNCPPIRRAEIEHYAMLAKCNIHMFAGDNNDLGTVCGKYFRVGCMAILDAGDSDILRESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA89</accession>
    <name>A0A061DA89_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769068.1">
        <property type="nucleotide sequence ID" value="XM_012913614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565423"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307860"/>
    <dbReference type="OMA" id="TPEYQNA"/>
    <dbReference type="OrthoDB" id="367023at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1953"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="482"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="911"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1801"/>
            <end position="1835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1975" mass="218625" checksum="E0479EED766C8D1E" modified="2014-09-03" version="1">MAPKALTDCPENLREAIDWLVQVRHCGGVSTLSDALCKPFHNVVHNTEGCSAPKDSENPHKNIIHNLCASAASLLGYRYPGTYDGSGIVYGNASRLCDAILVFLYAVFSDVHDNQPYVAGRDVLHDVIVELKSQLWRGHKGFCHVIPKVATGLQRYNAAVEASNKKVKEPIETVLDYLKPDGELRKGIQALQISETSTSTQDERTVESAVSLVERCKEIARAFSKSLMAATDAIDDLNPKLKKKLENARKSFFNHVDWLSRWSKKGQKKMLDKMIQKIKNRLKQLANAVKDKIRQEVHTVVELLKDRVKEIKMKLEGIAASLEKYVKELGQWMGDAKEYINAVKKYVEEIMKQLDGENRQAIDKAVADIDSELGKRVEELNQWIETADSAVTVAKQKADEVHKRLDKGDKNQKIGQGLQKIEAARSKVESVSSELKNVHSDLVSWKDAAEGVLRKVAGKADEVSGQLDPSQKGDGNPIGKNLNQIDASNEDIKKANESLRKQTEKLNKWITEADEIRKKAQDKAEEVYKSLTVHKELSDKIGEIQTANQTIKDVNSGLGDVDSKLGEWKKEAGRVLQGVVDRATEVHKKLNKDDLTNDINVGISQINAAKDAIAQVDKGLKSVNDDLQKWRKAAQIVLDIAVNRAEDVHEKLDPAKDKSTLGGQIDAIDTARQGIVDANKELAGQLKSLNKWIQDAEDIRHKAETKAREAYDKLSVHEKLSENVKKIMDAKEKIEGVNKNVTSQLVTLNQWNEKAKEVITGAVGKAQEVHDALQEGAALSRSVKGIATDNASMIEANKKLATEVQNLGKWKDAAKDVIKKAEDKCGEIVEKVKTSKDSMIFAEASKLKDQGIKLLKAATEARQTVESKVKEALDAVKDMDADLKRDLKVVKDNIKLGIAEVIESLKVGDLGDKVKEDLVKLRERIMKLAENGRVESLVEKELAELNQKKSETLDHAKQKLTEAEKQLQSMFESAIKTPLDDKVKTVENAIEKLYEKINPDGGDASREDKKKFQTIFDHIKKQVGVIKGTGTKSHESGIDGIVANVRGLYNAFVDSRGSGVDDRVDGWLGNILGINENQRKTQTDGMKAVTSWINVYNGKARKLEDTLKIVKDQIKGALSDQIDTGQRQITRVDAEDNIVQNLTKVKEACRAFAEALDAKLTNIEINNFTGTIVSDVQSRFEGQRRRSSSVNENLKTAVRAGLIALCSCVRQIAIEIESLAINKFGRIIDKIKPTVDGLNDKLVEATTPHSTGEANPDPGTAQAVDKAIEGVKKDVDGLDDKFKQEVKQPLDTAVKELEGAVDTFNEQAKQQVRDAAKGAIDQAAKQISDNGRDIKLSKNGLMQHFNGAYNSIKSNLPKDLQGLLDKHIGKDEVPYVGIPYKVKLSKDFDKYLKHVSAGVLTGHPHGPLAEAIDKIGGEGMKELGVIHPRHIGNDKIDEQTFENPFKAIQLQLEDITKLVSDIRTDMTGEPASYRNGIKNYLEQLRKALGDGKLAGAEKGLDAITKAIGKLQRNTFGPKSGAIGIAVEEMRKEIEELKEKLLSEQDSKDDVINALTYLQKHGLASETWNGKYGNPVDGLKKIEDEFNKQNGALLNQTHQIETATRIITNEIQDALRRVGMKLNHTILDDDVVDKLEALQFMIGVGGHGGLQGIFDVINQLWVKQFSEKPKAIQGATGAIRRELKQLQSDLQGDRNYGVIETLRDLRDVGLSKNVWQKYDNTKGLEAIEEYFKRHQEVFSQQPRQIESGVKDITEQLEGLRTALKDANGHPKDDVINRLGELLVTGLNGTEWNIGKGKKTASLGQIKKDLRGQNDKLAAANKKIEDATNTVMSETQDMLRKASQKLSGDLISDTIVKNLQLLEKMIGSGQNGDSESLQAIQKVISGLQAQQFDVKFKTIGEAKQNIEQALTAQKTALQNEVTNPLKELMEQGLGDGKNWNGKNAKGFDHIKRNLQSQQSDLSKHPEQIDLGMKDITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM6</accession>
    <name>A0A061DAM6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769789.1">
        <property type="nucleotide sequence ID" value="XM_012914335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAM6"/>
    <dbReference type="GeneID" id="24566144"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400950"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="6509" checksum="752508BC778E3EC3" modified="2014-09-03" version="1">MAINITHSVTNTSLNATSSQFNCGKEGVAKTTRRTRQLPSLLPITLHDHMEAFSPEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP2</accession>
    <name>A0A061DAP2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766966.1">
        <property type="nucleotide sequence ID" value="XM_012911512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP2"/>
    <dbReference type="GeneID" id="24563321"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110770"/>
    <dbReference type="OMA" id="AGSEYKF"/>
    <dbReference type="OrthoDB" id="365966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="21661" checksum="7BD17834BA5450FF" modified="2014-09-03" version="1">MMMPAHCPKDAGFAFVTECGNHYIDLGTFNDNVDREPFVITVHKSKVDEPLVYTVAALSQISTGYQWMCVGIFNDDEHREVKGRHQKYFDDILTKEFMEHSMMYRQCVHGIQMDPFVEQNVKRTPVDAAMSEGDKGVSTSKTSVGQPENSKAILTITPTITEGKYHIVFAYGSPFRGPKMVCFKEVIVKVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAX4</accession>
    <name>A0A061DAX4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767051.1">
        <property type="nucleotide sequence ID" value="XM_012911597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAX4"/>
    <dbReference type="GeneID" id="24563406"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200220"/>
    <dbReference type="OMA" id="CCINVTG"/>
    <dbReference type="OrthoDB" id="360354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="344" mass="39468" checksum="EC77F8D211F5B31E" modified="2014-09-03" version="1">MSAILPHIADHTDARYQPESFYLPEDDGQQEHAATRLNSLTTAHTDTPSDGANSIVRQRLSYPDEEEDEDNMRGFDEQLVKRKSVLLNAIGRFKAKHADKMSLPEYMMHAYVILHTVNENTILTYEIIAAHTKMEPESFTKIMRTQTLSRLEQEEFDLDALGIFKADFDNDEELAQMDRQFTWLCECCCAVVDDADEDSMMEQIKKKRLEAIEANKQQPEPEPQQQHQQQASQNADKKHCPSANFSQLVPIADLPNDVMYEALRQHGNRLVQRSLCTSNKRQFGASTWSHNQNDASVISSSAAGLRDFADDIQRYSVDNNTNDYYGEERRLSARQTALLRKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB40</accession>
    <name>A0A061DB40_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0201020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767131.1">
        <property type="nucleotide sequence ID" value="XM_012911677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB40"/>
    <dbReference type="GeneID" id="24563486"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201020"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="829"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="959" mass="108201" checksum="042281AA878475EA" modified="2014-09-03" version="1">MAKYIGAPLAICAIILQFIGFIDALEYDFRNLMSSLDANPLVAFHINMDHIGIATLACPRHVNGTEYVWHPQPTADHGASLKTYVIEDGKFHSVPFSKVVVTEVQRSYAWKVSNDSQTELHIDVVDDHIYAITEGRLAFICGPRDLVLSGALQGQLARLREIYEREDHLSNPTTLLVDQISEPGRSIGVAYLHRGLKHKLLQGCGSRPSKLFAPDNDVAVDPVTGTRSCVVDPMSTLRTGFVCQGRIEPDDCMRYLLNRTGRVVTAPTPHLYRNLNNRGKWVVARYFNDVALPRFNGECRCIDPVTGHVKARMEIRWKTEYVCDIASMIARNRVKPISGPWCSVMLHPGATLTIKLPKQTVKSTAIGDEYIEDVDDIDEDALRVPYSQLPSTHAYESEFKPDTKLTLRQIQTIYDVDLYDEIVANKAFTCDVIEVDVSQKERGEVKLKYRMDRPLALRSGHNSFLYHWTVISRNEYIIEKIRAVVNVSFAPTYRYNIIGCDRWRPSMFDPEKDIGSHTIRDMRNGMALTSEWLLNVVSGEEQAGIRCGPNEELLPNNCESTGYDLSSNQIAPFPTAVRNATLYPVRGFQVLAMSFQNVPVSHACSCVDEHGHETSRLILRSNRSEEYTYTVRREEAYQRLLPYSLLPWSEVEYLHYHHAYIQSVILHNTPQIPIKLQSGTEIFMRCVMDEASYDDGNNANALPIWLPYYIRFNHYKADTTTEGPMLIPMPNEDRIAGTKGGLDIFMPEYTDEYSDLIIKSNSGAILVSRDPDYSEYVPMTFVCGKELSESDFDQINDGAHGATLPHALAPLEEYTWNVVQIDVEMTDPYIQGCGITDSRDKLFKPETPKIYNSEGKAIGCKIDLQTAGEAAFYCPVPYVLDPPSCFNQVYVEDEVKNLSDISQSLVASHSNHFVILRFDSDSVGPGEGLRKTPPLECRCVTTKGIVLSRIHVESYYSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB99</accession>
    <name>A0A061DB99_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0311550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769438.1">
        <property type="nucleotide sequence ID" value="XM_012913984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB99"/>
    <dbReference type="STRING" id="5866.A0A061DB99"/>
    <dbReference type="GeneID" id="24565793"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311550"/>
    <dbReference type="OMA" id="CLHAFFD"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="90"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="416" mass="47742" checksum="E0F15CF2A729A6D3" modified="2014-09-03" version="1">MRQPAAGRYGESEDADARAVLYRQHQNAMYQQRCVSYNRPAQQLKDETGQNWNQVPEVERAHGIPDGREMAQGVQAARATDPQVNPEDKYQVERMIGNGSFGVVHEAVQKETGKRVAIKKVLQDPRYKNRELGIMLELSHPNIVFLFDYFYTESVREQERQRYLNLVMEFVPGTVHRVMRSYFKKYSQMPLKLIKIYAFQLCRALGYLHSMGVCHRDLKPHNLLVDLQTNVLKLCDFGSAKKLMPGEWSVAYICSRFYRAPELMLGANEYTTAIDIWSIGCVIGELLMGKPMFAGDTSVDQLVKIIQVLGTPTIEQMHAMNPNYTNVTFPNIRAADLSRVFPRNTPAVAIEFVTLFLRYDPKERIQPLEALGHKFFDEILYDPSPEIHVPENLLDFTKQELELMSDSCKQKLGIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBA1</accession>
    <name>A0A061DBA1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">-ATP-dependent RNA helicase dbp9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770162.1">
        <property type="nucleotide sequence ID" value="XM_012914708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBA1"/>
    <dbReference type="GeneID" id="24566517"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404630"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="102" mass="11049" checksum="BAFFD43C71301EFC" modified="2014-09-03" version="1">MVSFEESADETVTPPSVAAKSCGDNDSILQFGRHRLHPTLVEALTGSYGTFTDIQTKAIPQALAGKDILVKAQTGRIRAALHLMLTSNERISSALFRNTCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF3</accession>
    <name>A0A061DBF3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl CoA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0403510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770049.1">
        <property type="nucleotide sequence ID" value="XM_012914595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF3"/>
    <dbReference type="STRING" id="5866.A0A061DBF3"/>
    <dbReference type="GeneID" id="24566404"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403510"/>
    <dbReference type="OMA" id="GDCNIPV"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF115">
        <property type="entry name" value="ACB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="88" mass="9973" checksum="A2D4242DFD084D79" modified="2014-09-03" version="1">MSDTLFEAAVKFISNGTGFTATDEDKLSFYKYFKQATIGDCNIAKPGFFQLQQKYKWEAWDSVRGMAQEAAKAAYVALLDKLCPSWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY0</accession>
    <name>A0A061DBY0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770274.1">
        <property type="nucleotide sequence ID" value="XM_012914820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBY0"/>
    <dbReference type="GeneID" id="24566629"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405720"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="7280" checksum="E0B608264CA10E8A" modified="2014-09-03" version="1">MTWEGIVTKEHSKYRRYLGISDRMDAHIPRVVIQETHEIVMRDMEPKEDYDFVEDLQALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY9</accession>
    <name>A0A061DBY9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0303130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768595.1">
        <property type="nucleotide sequence ID" value="XM_012913141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBY9"/>
    <dbReference type="STRING" id="5866.A0A061DBY9"/>
    <dbReference type="GeneID" id="24564950"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303130"/>
    <dbReference type="OMA" id="APFAKWR"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="200" mass="24034" checksum="8C029750369A6F43" modified="2014-09-03" version="1">MGVDSSRGGIIGFFVRMHQAYLDRLSSYVFIRWFYISFMTFIFWHHVIEYGMHYVVAYMYAVYLLNLLIRFITPLDFDDLCKAHEAEHGGTILPSNENKTANITLERMKNRENIYEFRPFLRQMNEFTFWLSATRATHAALFCSMFEFLDVPVFWPLLVFYFVLLFATTMREQLRNMIKYKYIPFDFGKKSYGTITRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ9</accession>
    <name>A0A061DBZ9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768610.1">
        <property type="nucleotide sequence ID" value="XM_012913156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBZ9"/>
    <dbReference type="GeneID" id="24564965"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303280"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="10311" checksum="6265A39EC4BB16A1" modified="2014-09-03" version="1">MLLSNFQSSDNKRMIDHLSNPSLNQVAIRRLPLVSWLSIPPLIWALSSVNDILRQLTNKLFQHKHINHSSVYSLSDFDANNDHRIMMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC90</accession>
    <name>A0A061DC90_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clathrin interactor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767591.1">
        <property type="nucleotide sequence ID" value="XM_012912137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC90"/>
    <dbReference type="STRING" id="5866.A0A061DC90"/>
    <dbReference type="GeneID" id="24563946"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205630"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03571">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="430" mass="48498" checksum="884D699619338D5E" modified="2014-09-03" version="1">MEGVNAANQQILLLTLGEVDKRIKEALYSNDVGCPETVLYELSQATYHAAFMERISQATWSCLKASNARARRIQKALTLLTYLALNGAEGCASDILTRLDDITELHDRKLPEHMRDLEIIIKDKAINLVSLVCDKQLLERKRKEAASLRSRFVGVASNNGHVATQILYKPIYAVDAKEGLLSRAASEAWRKWNLMFNVNRGKGNGGKIREIFNRIKNGQIRNQCSKSSQILRTLGTRTGSEFYPPEGCNGYTPGLYRSSMEEQDRHRDWAHRNESSSSDYEGSTSEEGSDSSIDSAYSNVDSIARHHRNDSGVSSLSTESASRSVYEESGAIPAQSIRLHRQPGRTDIKVENYSHKRTDDGIKGPWKYQLGHQNKIVENIERLSLNDAHENYQLKGKPVMLQQTNMYDGSFAHLQRNTYRANPFARVSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE2</accession>
    <name>A0A061DCE2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768845.1">
        <property type="nucleotide sequence ID" value="XM_012913391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE2"/>
    <dbReference type="GeneID" id="24565200"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305620"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="158" mass="16918" checksum="2AE6D736F25B102B" modified="2014-09-03" version="1">MAVTWLVVEPTGGEECPWLSLMGLGGTGEDDGRGSVKDPTYKCDPSVCEKQCKKCTNSRCKCLCPCCKSRNGGELTTNCDSHSGKPLRSLPSSSSRGSASHGHASASRAKQQTGSSSTTASTPIPYIIASVALIILVICVMSYFRIRPFHRVLYLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCI1</accession>
    <name>A0A061DCI1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768915.1">
        <property type="nucleotide sequence ID" value="XM_012913461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCI1"/>
    <dbReference type="GeneID" id="24565270"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306330"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="74" mass="8173" checksum="64483C9F96B23829" modified="2014-09-03" version="1">MAICQGPCVRCHGRRAGLSSLHTPTFIALREPEYLPSETEPGLRRKDAALCALANVSRKLGDETDGRHFQTRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM3</accession>
    <name>A0A061DCM3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0403600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770058.1">
        <property type="nucleotide sequence ID" value="XM_012914604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM3"/>
    <dbReference type="STRING" id="5866.A0A061DCM3"/>
    <dbReference type="GeneID" id="24566413"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403600"/>
    <dbReference type="OMA" id="ESAHPNR"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="226" mass="25363" checksum="0042944AE5EC5E3A" modified="2014-09-03" version="1">MTDELTGSLNDRATASNASEVCSNLLTNIRLLPHPMTCLAHIAFKVAILSRYFIMPYVFGSMTGAYPDFILTFELIGVLAFADFWVVKNCTSSTLAGISWYCDSTVANADTFVHKRVKDEMFLNKEESAFFWAVMYIWPALWVLNVAALISTFDIPWVGVKVWYTHNIMQLVASGVIVTFALINLVNCLKCSQDKREKASKLTGKLADKLMGFITRSYIRSQTIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN5</accession>
    <name>A0A061DCN5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0306930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768975.1">
        <property type="nucleotide sequence ID" value="XM_012913521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCN5"/>
    <dbReference type="GeneID" id="24565330"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306930"/>
    <dbReference type="OMA" id="FYCPEPY"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596219" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="28"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="855"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="984" mass="110375" checksum="B9B5B31883C9F8A6" modified="2014-09-03" version="1">MAKVSSQRSIWAFCGIWLCSIVRLVASNCDFARPRDILASNALVACHKNLEFTYSASANCPRRVNNIEYVWHPQPSSDENGQINTYVGESDELRTVPLSTVLRTEDQHEFITVESKFLVTDIKFTKPYTRTFAITQRRLIFICGPKYLELNDELQRYLHRLDNFGPNQVLPWNVGSPMIQEISKIGGGLGVFYLVRGRMDRPYQGCGSRPSPLFDAENEVSIDPDTGTVSCVADPMSLSPIGFVCEGLIEPADCMMSLINKSDEVATVTTPHLYNDFEKNGKWVVARYFNGLALPPIDGECRCVDSETGRVKAKIEIRSKTEYVCDISKEIFSKPFSHVSGPWCSVVLHPGSTLTIRLPTEQINTAPTVRASEDDVNTNFDMEVDEDASAVALSPLPSVYDYETEFLPSELYTLRHLASVFGFVIHDESMHHEAIAGDALEFDVSQMERGEVKIRYHLDKPMALRHASNAFYYHWTLISKDKNVRDKVRGTIALHMAFTHEYNIIGCDRRPQSVFNPKISQKHCSVKSMGNGIGDVYECAAPIKEDFKQTAGIYCRSDEELLPPTCQSLGYDLRKNRIVSIPASLRHATPYPIRGFQLFDYFYRSNNPVSYACSCVDQRGYEKSRLIVTSHQHENVTSIIYGDYANPTLLPRILLPWDEVELSSEGRTPPAPLVLKHVSQESFELDLGKTLSITCGIAAAWFSHGNTTYDAPHVRIDEDLAATWLPKHPEEFYYSVNETNDVIELVKATYGSSIVTTPGGFQVGYHSDENGTEPSKLVLRSTMGAILISKNATYKQFVPMTFVCSKRPEPSDLSVITDNASTSDAPEQPIANALESATGATWNIVEVKVEMTDPYMQGCGVTYSSTELFKPETPKLYDADGQEIGCQIDINTAHKAAFYCPAPYVMDPPNCFTQVYVGAERKNLKDISESLMAYRSSHFVILRFERLRIRSKETLRQTPPLECRCVTAKGVVLSTIQIENYYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN7</accession>
    <name>A0A061DCN7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier-conjugating enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0208390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767871.1">
        <property type="nucleotide sequence ID" value="XM_012912417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCN7"/>
    <dbReference type="STRING" id="5866.A0A061DCN7"/>
    <dbReference type="GeneID" id="24564226"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208390"/>
    <dbReference type="OMA" id="LWQKNVP"/>
    <dbReference type="OrthoDB" id="10256182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061657">
        <property type="term" value="F:UFM1 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11686">
        <property type="entry name" value="UBCc_UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014806">
        <property type="entry name" value="Ufc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08694">
        <property type="entry name" value="UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="19060" checksum="14F0A6E9938989A1" modified="2014-09-03" version="1">MSDDGSAGAGVRSAAESTHSPSTDGIPLCVTKAGPVDGAAAWENRLNEEFAALIHYVEENKANDTEWFQIDCDDQGTKWFGECWHVHKMKTYRFRLEINIPAAYPNAPPDIVLPDLDGKTAKMYRGGSICLDAHFAPLWQRNSPKYGIAHALALGLAPWLASEVPQLIASNVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR1</accession>
    <name>A0A061DCR1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exosome complex component ski6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0208740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767906.1">
        <property type="nucleotide sequence ID" value="XM_012912452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR1"/>
    <dbReference type="STRING" id="5866.A0A061DCR1"/>
    <dbReference type="GeneID" id="24564261"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208740"/>
    <dbReference type="OMA" id="ECRINTH"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="33"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="254" mass="27815" checksum="368D2484BEA8AE79" modified="2014-09-03" version="1">MAKIEYISVEGLRVDGRRPAEVRNIEILCGPECGVDVNSYDGVAQVRQGLTKAQAFVKGPTDVGRNKQRSQLETSDSPVEIQCEVVMPCEKRVVGNKMDHQSADIAQTVIATFERVVVSHFYKNSVIHIFVNVLENDGGVKATVINAVLVALVHAGIAMRDLIVACTAAMLNRQLLIDPNQLELNASVMELTLAASVSKEEIMYLDLKSKHAIKSVDGIIIKTIEASKQFSILAKAKLKQYARDYLELNSAVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCX2</accession>
    <name>A0A061DCX2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769140.1">
        <property type="nucleotide sequence ID" value="XM_012913686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCX2"/>
    <dbReference type="GeneID" id="24565495"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308570"/>
    <dbReference type="OMA" id="PSPINHF"/>
    <dbReference type="OrthoDB" id="365006at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="334" mass="38406" checksum="22F5FAC47C4C7E30" modified="2014-09-03" version="1">MLIEHNMPNICIKMQSLVCRYGGCCTIWESWWQQATLSSFHTYRKASHERGIWRVAPNTVHCHETNNYGHCGSFDKRFSHHSAQRGKYYTNRFYMKKCKACALWNNLSVMQCVHCLTALGDEDIRLRVVDPLCRTANSRRGETENGTVEYVMLHRCFDFTIMVHPQPSAAIHLSAVPNGTFYDIKNFRKTHVPMITKMKSRCDAIIHDVITGHAGPDYLKNSVSVNHLRGIIQAPQRGSKRRKVSDIVSEAIYGFNYPNNFSHVGMHAIVPPIKCFNLFKSPFFYPLSKVLSDLEHLSQVKAYTADEAKQLYEKDIIMEEIVDIDATFRAQYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCX6</accession>
    <name>A0A061DCX6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770253.1">
        <property type="nucleotide sequence ID" value="XM_012914799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566608"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405520"/>
    <dbReference type="OMA" id="KCYVDLY"/>
    <dbReference type="OrthoDB" id="361369at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1285" mass="145131" checksum="152C2C15B742DDBA" modified="2014-09-03" version="1">MPLSYCCHIIASIELRYASDTRIPKKILRAFKYPRIEDHDEAPGSSSGEFLASPATWMDDVDVCNSILQSHGYSIGGGALSIRKLDSNAGQPIKRLRNQPSRGEPTSGQTPITENGNIDGAVMSYICGIVRRSMVYHLCLYDDYSKDFEHIVSKPSDVTRDICSIRKHSAYEMLCSLRDCLTQLRSRSTDTMEAVLVTDEYSGIFTNEEIIITRSTIGFRNMLADEGIKFYNLYDPASSSSGNLLALENWGNCLDNLVNDYLQMSTTKDREDNQEPKSDELAIVPVSDGAPFVESTLPAKDAFFKALNLPVSDHDINVLTVKGRAHCRKLLKFLDRLCKSALLKLKSARLHCAPVKIVLSNFPVIFSKLQELRISSDEMEDGVANEHNSLSIRGLILPGVLNGIFKVVRRMQTQGTIQDVSITLTYNTDMDAELHESMLQISEKNRIYNNFMANVNSLESTSQRIYRTLRKLVPFTNFVVHKGRISVPYKGALRDHGHIELSHPDNVPKLESRTLYLTDASLSQEHMRPMPAESEQSCDKVVVLKDTLYANLAMVKFTMEHLEGAHTVSVIPTKSLIDEVLSYVPCISASSEKDNSRFTKCYVDLYPILNNDNVHATMDIQPYHLVNLAWLMGYLLHRGGFLPFIDRESCNESAAMQTLDSDLLYSSLSLSRSLSEEFSVFLDGSVPEMFKTDVSPMAGDPLAQQSYIIKLVHHVTFNKRFQNLLGMSYHEHARRKLEGMPSLDVKRKVSNDTISLISRDTSEGYTAVLTHSWNTLLRRAQSESITTDSGKEHDDRNSGTEDLPTSLNSSHNTDVITLDKIPEQPWQTQTSAGNLLNMLSATADGAVKRNLLRTESYQSVSSVTRAHGRVRHCVFDFDTKASLKHKSDRSKLQQEIHKTYRPDHVQGERSGSNRHLVFVLLTNDAVSSLASSRIKLVKDVINSSDVMFLHGENAEESEQPIEYNAFNAQNVERRYKLESTAAVAEDYYIKGGMSYSFSLGVSRLLPHLARLHKKVSFKHRSFKSFCNIELYYVRMDSGTSPRESLSVHSLIAPDRGTARSIFPGRVIVEQFVSYAWLCDVYFDGCIDLRAEIRQCQKMSTAGESMIDHYFSRDDAEQHRKSSHRSLTFSGPYRDVKFLWGWSIYMLDRKNVAVSDDDALLFKMHCGICIRVHRSLNDIAKEVKNDLGSRLKRFNIDESDVSAFFFHPRIYTNSLVLLDDATLRSSDLEHLKKNPFYANGCVRETFGGFPICFGRYEGLPLLSLRWLKDTLQNGRPEPIAKYLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD01</accession>
    <name>A0A061DD01_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0209980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768031.1">
        <property type="nucleotide sequence ID" value="XM_012912577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD01"/>
    <dbReference type="GeneID" id="24564386"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209980"/>
    <dbReference type="OrthoDB" id="10364633at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27053" checksum="33554BB4D2BEC911" modified="2014-09-03" version="1">MVWLEGIDWLVALKGDDAEKNLAALGAALHKFLADKPVGKMVLPALEKAKIFSKDLMTHKALKDQWPANVMLERFITPMDKDPGAFAKIIGIVDESDYKNIVQARGMKPEHIAKDLGKVVDGCEKFLENIKNADKYESTYSSEATWAGSCVEDPEACAIVLVGMAPMLYVGLRALRMASLSETQSWLHPGALEHLGNVLNALGYRGSGCRANMSGSYLYKLLQYNVNFKVLETIYRLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD32</accession>
    <name>A0A061DD32_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CDT1 Geminin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309620</name>
        <name evidence="4" type="ORF">BBBOND_0309720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769245.1">
        <property type="nucleotide sequence ID" value="XM_012913791.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769255.1">
        <property type="nucleotide sequence ID" value="XM_012913801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD32"/>
    <dbReference type="STRING" id="5866.A0A061DD32"/>
    <dbReference type="GeneID" id="24565600"/>
    <dbReference type="GeneID" id="24565610"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309620"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309720"/>
    <dbReference type="OMA" id="PHENEHF"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01075">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDT1 Geminin-binding" evidence="2">
        <location>
            <begin position="363"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="752" mass="84556" checksum="975A87B04667FC3C" modified="2014-09-03" version="1">MECLLPPNAFLAEGQTSFHIEEDATKCVRDAVDEVIASTEQLDQPTTPLCGPRGEGTFEEFTAEDFIMPPHAVDVKLGTPKLRSKYASPSVPLPGIEEASSRSPTMSMRERVQWRQQLLSNSSRLDVSNAESDSGTLFGEVANKNECMSSEVTPFRGTSVRTPSRWKKRETDSRHLLMRTIGRNDNDTYVNVSDDLVKNPILANSVRSAKMRKYPDDEEVERSLKVLGSSRCWTDRLEDRANGFVGGDLDDDDMLATQTPIRSFNTMLSTSQSDCVYDSTQPASLCSSYTQWNNASPISTPGRSTGVHASSTPNRYVQAMFGTGYATDLDAFGGARLEDMRKEEVNPMAYARVPKDMFSEAKMGAQMGTLYKHFKNMCTFIRRSSMRSDRPYFKVVQLMVQRMSRKAFTMDQLRQMAWMAPNLVTLKWVRISESVRRRYKNEYEECRGDLVSDVQVRIHRQDGKVCSSNSDFESTCLAFKSIMCAWLARCEAEHVQGRGSCDGFVPEMALPIPMAALPTKQCGSLVTDNAMLAPMSTPSRSASRMSQCAETNPTRSTALLSTNRRPHENEHFTTSCMLRSPDSASNKSFNSHYESDSTRYVGLSTKRMRETPMLPMDTELLDTPGMRRIRESAKRLATESANSVKPKEHDVSYWKDVRRFVNALVDLSIADTSPPVLRIEWLAEFMTKYGTKRVTYDEVAEWAKTLTHLAPEAIHVGVSKFDDYSTVLTFGPQPTFDGVIRYVNQQIDACNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD38</accession>
    <name>A0A061DD38_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0309770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769260.1">
        <property type="nucleotide sequence ID" value="XM_012913806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD38"/>
    <dbReference type="GeneID" id="24565615"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309770"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="160"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="369" mass="41515" checksum="D05D6DD5BB3D67E2" modified="2014-09-03" version="1">MCQLASCSSRWILRGRWLLHSAAAWRRGAAVPPGASSLLCRPLTRDVRAVSSGSSDNRLASAPAVANVDDSVAVASAADSTAVTPAASPAEYCNEILSDPLSDVSVEESARFVVPFPNSDRPHLLEVITRPFRQNYTFGAASIMLHLCVERLENEELTAAFEIGPGFNRRAYLLFLHVWLLHRRAMKECPLGILLDRYLFRCAFELLGEWLSMRGVAEHRFKRERENCQAFMMKFLVELDQCTLDEELYAYKLSRALHDHMYEGDVSESTVRLLVKYVLRQFTHVSNLDSRVFLEAMFLWFVFASAPEMWLRADTEPICKPQRLLKRAMPQLIKYGGEFGQEHTALPAGYRPPTADTAKLGPGSTKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDD4</accession>
    <name>A0A061DDD4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768371.1">
        <property type="nucleotide sequence ID" value="XM_012912917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDD4"/>
    <dbReference type="GeneID" id="24564726"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300900"/>
    <dbReference type="OMA" id="MMARNSH"/>
    <dbReference type="OrthoDB" id="363593at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="29113" checksum="F9CE3946FC2AA69C" modified="2014-09-03" version="1">MSTEKKDSGENWLGLCTPFTCLTRKERPTEEYQEKLNAAMTVTKVTAESNDSLNRLATIFERLFRLDRQVIQLKAREAFVKSCLTDGEQFNIKIIAKGIHNIDDLTKQMVKEHDIDKESLVEILNGLKLPQKSKLTDTVKTITYHLINKLSYIQHDLDDSLREYDSFHNASIDEYEHMRKRFFDLTLQRKKKTNGIDFSVSKSDFMFIVNSKNSRMVDIIFSLLDNDENGVIDWGAFELNSGRILSDAKGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDV3</accession>
    <name>A0A061DDV3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769905.1">
        <property type="nucleotide sequence ID" value="XM_012914451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDV3"/>
    <dbReference type="GeneID" id="24566260"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402100"/>
    <dbReference type="OMA" id="GWICSSV"/>
    <dbReference type="OrthoDB" id="366147at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="231" mass="25340" checksum="330FAEE61763C0E0" modified="2014-09-03" version="1">MDQQRSSSNNEHNTEGGGAEVGYLDGGTHRAQVVLQYARQITQSLKSAVLYAVNTGKQANDSLAELQSQNENISRIKAQLTESHKTVSATQKIVDAYVNSVRWISSSIAWQRPADVPEAQPASDGVALTYNIRNLWSSLASRSADAGEASNCIGQVSSERDPVKSALVEFSSTANEHLDVLIEELKSNRQKTELIAETVHRQNEELERIGESAVSLQDRVAQVNRVLRDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDX8</accession>
    <name>A0A061DDX8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">-mRNA 3'-end-processing protein RNA14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0402620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769960.1">
        <property type="nucleotide sequence ID" value="XM_012914506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDX8"/>
    <dbReference type="STRING" id="5866.A0A061DDX8"/>
    <dbReference type="GeneID" id="24566315"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402620"/>
    <dbReference type="OMA" id="NMEYLYG"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="4">
        <location>
            <begin position="227"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="889" mass="100599" checksum="8194D67C6AB6FC2F" modified="2014-09-03" version="1">MEEQGKPQPARVVTANKLLHSVLHGSSPLLPPMLNGVKPKNEPGKAVLLESIEDDQVWFTYIKASKDGGLLEEACRVFPNYWKAHHRCALYHVYHKQTRKAFDAYVSAMKEMDDYDLYICYLKFLYCMASVHEYIAGLFTAVDKVGMDLRSDPLWRELIVVLVKIYNCNLMDHNVHTGLLPNLFPPDSETVSVSIPLYPSETEQVVFRGVNSLDKGEQTYVQLYGDVNHIRKMFHRWLRSPTNNLKQALDGYSAFENIASAANVLCTKLLSEAKTTYETSVAVYEKLSGMYRNVLPAQPARRRQLNAEQTAEQQRQVGFWTEIIKYEESNPLGLPASELAARVLFTLRGALSPHIFSDSLWYMYFQFLLANDRREKAVETLRYAIRNYLQDDGKMQFVLAAYLDDGGESAATEFGRLIDPGLRLVEDGETGADETQLRHILRFDASDSSTAVQPARLIHYLNYVRRNLGRVKWHEDLQVILTKRELLSWELYWYAADTEVRCFGDVDAAAAFLSEAQQSLPFDMHYTMLHLRFLLNMGRLVDARVLLTQLVVGANVAGETKCKPTASDKIALWHFWLHTEYFYGTKAQFTQVRSLFVQFRVASEVGLDVFAEKSHRNGVSTIRQIFGNIGPSFIKAHMDSSKRVATADMHAVVELRKHLFCVGLEYDDLDRVFFFATRRPEVAVEKAASSEKEAEKYISPSNFAHRSEPDQDSTRRHVFITRPDVAALAPLDPHNVIPVESMITLHGGKRPPLPDAAKPMDTVATPPKVLFDLLRVLPNPNPRGPFPKMYGNAEAIDHLIRSLECAGLKDVQLLDYQPIPVNQLLHLKKVGASDSQNIEESVESAAKEGAFELNNGLFSILRFVEGHVGADEASRLRAKRASKKQKLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDZ5</accession>
    <name>A0A061DDZ5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HesB-like domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0306240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768906.1">
        <property type="nucleotide sequence ID" value="XM_012913452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDZ5"/>
    <dbReference type="STRING" id="5866.A0A061DDZ5"/>
    <dbReference type="GeneID" id="24565261"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306240"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="4">
        <location>
            <begin position="106"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="212" mass="23402" checksum="DB3380D11691C46F" modified="2014-09-03" version="1">MMLRRFFSSCSEALVADRRCFAAISFRPFLLQAPPSSNRSIPSVETPNSQCIVPPSAYAAAELVKTRSRAWSPLQPCTVHHALFSTASPTFEVKRRPVNSRKGQIVTLTSNAIKRLHEICNTPGKIVKLLFVVKGCNGYSYEMELVDISSLDAMDEIVRDQAGAPVLAIENKAAFHLLGCHIDYQVSQLEEGFVFDNPNVTSKCGCGQSFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE32</accession>
    <name>A0A061DE32_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">-85 kDa calcium-independent phospholipase A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0404170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770115.1">
        <property type="nucleotide sequence ID" value="XM_012914661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE32"/>
    <dbReference type="STRING" id="5866.A0A061DE32"/>
    <dbReference type="GeneID" id="24566470"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404170"/>
    <dbReference type="OMA" id="PMWLAGW"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="334"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="655" mass="73679" checksum="CB90356ED7809154" modified="2014-09-03" version="1">MVTKVSRKRLTSSLYDKLYMRHLDCVDHLCSGESSNVDTNSEYEEVYESACSANESSPPDSPQRLPAKEERADITQAIVYKPSKIVQRHSRVSPPTSEDEAAVEVDPFGRYSFGEAERKGRSSWKKNIVTAFTAYARTNRSNGYRGDNTEESENRPEVLYDMWADYMDSDDSSKNDENTIKGTVYGTDSEHVPLKKRGFYTIFLRNPKAAEKKTKQDIYLARVKFTYKIIDCNRKREEVRIQGNAPPESGTEVSFVPHDIFGDDSFCLTNEGSVTVAATTKIVLICASDDSIAEFSITHNPLNFNPSLLYKIVYGGWCSAVPLSITPKVRLRVLSLDSCENLGTTVLETLYTLETRISAIKGEPCNIADYFDVICATGSGALLALCLLKGYSAKELKLQWQSILSQLFKWPHSLAYGLIFDHLSSSQYAKVWIDILGTDFMCSKARPLCMLTSTQLKNKEQELFMFRNYTNTRGPYAKTALAPMWLAGWATTAMPTYIKGPTTAYLKEIGCKIDSEVQFADGKFVSVNPSLVALHEVGDLYGYTLRTLIDETLEIFLSLGSTRENGMQVKMRDSNTWQIVLNTGTTSDKIEQSHMTQLFEEHPEKYHRIHLPYVRGCKHGKTDKEWVDTTFAAAADYLQNNLSSSVDAIVEIINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE79</accession>
    <name>A0A061DE79_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770235.1">
        <property type="nucleotide sequence ID" value="XM_012914781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE79"/>
    <dbReference type="GeneID" id="24566590"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405330"/>
    <dbReference type="OrthoDB" id="419290at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="24430" checksum="3D100B7E7EE5B001" modified="2014-09-03" version="1">MEIWRHNICRKLVHIGCGITLAHINVPGAHLKAIIIAVAVISIIIFKTVPLRFGIKDDAGIIWYNLIVLLFAVFGLPLRVLLPVFIIDPVACIVGISTKSRKWCGNKTVYGTVAAGIASYFSLYYVRVQQHRILLSLVLPITEGIMRQHDNIGISVVVLLYYCAAQHFGWPTEKWKLMHHNSAYLSDIIRFILSSFKGFLDAVARMLASKLSHALLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE1</accession>
    <name>A0A061DEE1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769306.1">
        <property type="nucleotide sequence ID" value="XM_012913852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565661"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310230"/>
    <dbReference type="OrthoDB" id="366938at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600314" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1399" mass="155741" checksum="F6795D12FCF87AAC" modified="2014-09-03" version="1">MVSIIWADLVLLIYGTAIINVVGDAVKSTRQPSTAYHIFAAEPGICSPDLLKITDCSENLYEPIDWLIQVRYGNGDSDGLDELAKALKKLIEEAIEKATKSLQAEKDKLECPVKYTGHPSNCAYIDTLIEKAGKSKNPNGLNKEQLVKNKQHCQNNHEYYRSDAQKKALQDIKERETQLKDLTNKLSIFTENGHQKCTELLNNLCSGLETFLGFNPETKGYDGSGIVYSDLDRLCDAVMGFLSGVLGAVKDDEAVKTYDNMMSNKLEKVLEEVNKKIGSGREGLAVSVAAVKEWLEGYGNKVDEKTNNVITNLKTLRTNINFNISELSKLDNFDIAWPVWRDTVIGKLNETLQNATLAIEKLDKPLQVKIRNEFDEITLRIHELDRGAKSDEKEIEMLGRNVETHLEELYRDVEHKAFELERKCILGIQKSFNEDIQAPINIVSATLEEVRKKLSRWGEKAQLIVTAARYKAEQILTKIDKNKHSSTEHQNVVSAANALHKKAGILLKAIEDTRKKAADEVTGALSEVVKTNNALRYELNGVKEKIMEKVRDYVNRQLKGVDQLDKLDKKVKEGLVSLQSHILGDLNTYFEGLGETIITAATYATDPWGSVPRKGLQALGDQLRDTGLGTLPDVLTKLATEKTNSATKLFSSTIENLLMHIKEASNGQFSGGGTLTNPTFKELTEAITSGLEGAIKTEVAKHIGDDELAISPKIGTTLMKEFDGGDKKVKTLLESGIEGMVTGILEEKIGKGEDTDDGKVTITKANFSSYYDCIKQDGFTAKTILSGSASEGTLPDKIGNIKRIVIAALSVNEGTKPIDSTALKSALAAFNSKFEIFTDTIKKCVVNEQSMHDIEKKGVKGLLTDLKTMLTEDSVQNLNYDIQYGLTKLQKDIDGILGTNGRVNSANLGKIIAAGTEFHAKKIDKHLADCFSDIAAFLETRCDSKINSIKHEALYRHRDATKQQLEILNRGVRDRVDDIKSIIDTDVKTGVKGLMRWMGGELDASGAKSSTNKLDDLKTTVMSSDNIYEKFKKLSESFRYYFGLIYRHIKYEVNDPTKQLSKIKTNFDKLLNHLSASNSTKKYNYDKTFADLLSHLSSSLASLQPSAFANPRHPELLDAVKKGLQGFVTEMGRVYVNKYEGAQAINWNEKESYDNVNFAKITLTIIDLLERDLGKLKVDCSVNTRMQTKIILNNLLGKWFQNCGFRVSADESRQMSELHRKKGTSDLKAILIGGYKQLYNTDKNKPGTLLYHIHNYSSVCHLAMRPKPQPPTTINAMLHWLAGLYWNPMYSKIESHIPQWYDALTAGYNLKDGNLSVAVPSRATISKKGTINHTFVGQPLNTVTNRPYQILVRILGHGHAGGSYACELFTNPDDLDYPGNAGACFDLLVEVLFRVYQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEH4</accession>
    <name>A0A061DEH4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Surp module family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0311880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769471.1">
        <property type="nucleotide sequence ID" value="XM_012914017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEH4"/>
    <dbReference type="STRING" id="5866.A0A061DEH4"/>
    <dbReference type="GeneID" id="24565826"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311880"/>
    <dbReference type="OMA" id="FKSRVCN"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="169"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="5">
        <location>
            <begin position="303"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="414"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="656"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="797" mass="88505" checksum="E92D10B865F462F0" modified="2014-09-03" version="1">MAHVAAWLKRQKEEELAKEKERLETSKIYAEYVRDFEGTGAPATAVAATAPVRFVKSGEPAPKPSQTSHSSLAASGIFDAQAGGDPAAERVDEHSAEYLRWVTSNANAAAARPPATGKTQLKEKQQRQEEEKALQRRMRDSKLSPGLPDAAVHSAGVDPRRNSGSDAPCTIYVGNLPPSITEDDLERKFGRCGRINRIKVMRSSAADRPKQCYAFVTFSHPSDAQWAKESLDGAEILGYRCRLGWSYHGGGRSPTHGSSPSSYAEPAEVAVSPMPSSSNLPPLLADARGVHVELPPSPMKRAVIDLMARYVVQGGAEFEAMIMANESEQGLFNFIFNRNSPEHIYYRWKVYSLLQGDTDKEWRREPFQVVAGGLQWHPPVEKTDTSPAPPMPTVPPILGAETAMTMSHSGRAPMMHSDISRLEKLLRDCTTTRGSVAEAMMFIINHGESAFQVTDYLVNSILEDTPTVDKKISRLYILSDVLYNTSASNKFAWLYRSSFEKRIPEVFAHFRQFMKTSSSKIAVQQLIGSITRMLPAWRQWNAYPTEYIHGLESALWGPDFESFATLPHFEEHREAIDSTYDGEKMEYFDVLSRFPLKWREAAYRYLLMRVRKLKQLCLIRGLLTIPGDRSSLVTRLIINDMYVEAREAEIREMELAERDNDREDHERLSQSVSPYGGADTMEMEVGSGESEMRRPPDPAKSPPQPELGDAEAASDECSDVESASDAEVPNAAASESDDHMDTSSDVVGPDLDHEAPVDAPEQSSEVAAEEDAQPEEVAPPAPEEDPDDIEDMFAADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET6</accession>
    <name>A0A061DET6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">XBA-binding protein 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0403330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770031.1">
        <property type="nucleotide sequence ID" value="XM_012914577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DET6"/>
    <dbReference type="STRING" id="5866.A0A061DET6"/>
    <dbReference type="GeneID" id="24566386"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403330"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="113"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="8">
        <location>
            <begin position="244"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="443"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="813" mass="94938" checksum="A4C962B2E6306A88" modified="2014-09-03" version="1">MAQKWPSGHTGAGGDVYDAAAYLDTTYDRKKHEELAALYDERFHKEIDRYPDLCKPWVDHIALLKSLRQPGSNARVYRIKDICILETVASEVPHHNDGTATSGQERGNDPITERILATYERAVKYVPLSYKVWYGYIRDSIEAIKAPFYANPAAYLRINRVFENCLVHVYAAPAIYLLYGQFLRTQNMITRARRTYDRALLNLPITQHAMIWNHYLQFVKEVDLLPMGRAVLRRYIQLKPNHRETLYELLKRHKQYDEACVVLCELLNDDKFVSESGKSQYDLWVELCELVRDNSHHIHSIPIDDIIKEGIGKYSDQVAQLWVILADIHILRGQMHSARDVYEEALKSVTTVQDFSTIFEVYARFLEKLAKERKKTAGAATDVIITVDRLENLINTRAILMANVKLKQNVHNVYNWLHYAQLMQNDPNKTQQIFEQAVAAVDPKRSVGRVTELWTAYASHFESSGDIDAADHVYEKAVEGNFKYVDDLASIWCAWVEMHLRNQNFRRALDLARQAIDVRNKKDPNHVQQRLYRSVKLWSLCLDLEQNLGTIATCRSTFDLMVELKVVTPQIALNFATFLEDNRYFEAAFSVFEKCVALFKWPQLYYLYLPYLTKFVNRYHGSKLERARDIFDHCLNPGQDSKTGDVPAQYVKYLYFLYAHMEEEFGLVRRCLGILKDATKCADKGDQLTMIKLYLAKTAEFYGIVQTRNIYQECLEFVDDEYARELCGMYIQMERGLGEIDRARAIFIYCAQLCDPEKHEQFWKDWREFEVLHGNEECFREMLRIKRSVQAKYSKVHFNTEEIDVERDQPRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEU5</accession>
    <name>A0A061DEU5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF hand domain conatining protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0403780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770076.1">
        <property type="nucleotide sequence ID" value="XM_012914622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEU5"/>
    <dbReference type="STRING" id="5866.A0A061DEU5"/>
    <dbReference type="GeneID" id="24566431"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403780"/>
    <dbReference type="OMA" id="IQGMQAR"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="154"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="342"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="547" mass="61865" checksum="C354ADB05DF85F50" modified="2014-09-03" version="1">MAESLQDSPQMGDFRRLHQMCMDSLALQPSQDARLRKLFLRCDRSGFGAIDGDTARLLFKTSGLPDAALFDIWSLADVEGRGELDYRAFCLCCVLIAYAQSHPDFMRRPDWMWDPQLPARLMNMNAVSECNPLLDTAVLDDSARSDMPQIAPAEAVVYEKMFLALDHNRDGFVEGLDARTYYLTRNELPDEELLRIWEVADADCDGRLSIREFMVMEHMVQERVASLMPVSNAPPPEMPRPDLSVSGTVHSAAPTDRLPQPRSARSARQPSTNAIGDDKRMAQTGHEEIASTASSSVASVDPKRAAEERYDVKRDVEDMSSVPVEHRDAGKMVGSEATIVESRRLANHVESLKKHAEDLEHDLDKLDAENNYLRMLYKKKEDRMSELHTLHRTVSEEAEAEHAQLRIEERELNELQDRISAMRRQKMAAESEQQALKQALSHSEDAEQTMLRSIKNEQGRVAAIRSERLHNMRKRIDLLESIQPSNDKNSGGSAQNVRAISDTRVLHDSKGIRVAAPESVMERRLNPRITSIPHNEWATRECAGFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-04-14" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B9X1R0</accession>
    <name>B9X1R0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">70 kDa heat shock protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP 70.1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HSP70</name>
        <name evidence="8" type="ORF">BBBOND_0102390</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>Charactrization of Babesia bigemina heat shock protein 70(hsp70) and evaluation of its protective effects.</title>
            <authorList>
                <person name="AbouLaila M."/>
                <person name="Yokoyama N."/>
                <person name="Igarashi I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Argentina</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AB482178">
        <property type="protein sequence ID" value="BAH23087.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766096.1">
        <property type="nucleotide sequence ID" value="XM_012910642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B9X1R0"/>
    <dbReference type="STRING" id="5866.B9X1R0"/>
    <dbReference type="GeneID" id="24562451"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102390"/>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="OrthoDB" id="413580at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00080608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00082995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAH23087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="648" mass="70714" checksum="9AD11CA4590335C9" modified="2009-04-14" version="1">MSAPAIGIDLGTTYSCVGVYKDNNVEIIPNDQGNRTTPSYVAFTDTERLIGDAAKNQEARNPENTVFDAKRLIGRRFDDPTVQDDMKHWPFKVINGVGGKPTIEVTFQGQKKTFHPEEISSMVLIKMKEIAELYLGKPVKDAVITVPAYFNDSQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKKGSEEKNVLIFDLGGGTFDVSILTIEDGIFEVKATAGDTHLGGEDFDNLLVEHCVRDFMRINNGKNLASNKRALRRLRTHCERAKRVLSSSTQATIELDSLYEGIDYNTTISRARFEEMCGEKFRGTLIPVEKALESSGLDKRKIHEVVLVGGSTRIPKIQQLIKDFFNGKEPSRSINPDEAVAYGAAVQAAILSGDQSGKIQELLLLDVAPLSLGLETAGGVMTVLIKRNTTIPTKKTQIFTTNENNQEGVFIQVFEGERAMTKDNNLLGKFHLTGIAPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKSEHVTITNDKGRLSTSDIERMVAEAEKYKEEDENRRACVEAKHQLENYCYSMRNTLNEENVKAKLDSGEVSAALSAIDEAITWLETNQTATKEEFEYKLKEVEKVCQPLTTKMYQAAGAAGMPTGGPGGFGGAGPTPGAASSGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZE5</accession>
    <name>A0A061CZE5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0103160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766182.1">
        <property type="nucleotide sequence ID" value="XM_012910728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZE5"/>
    <dbReference type="STRING" id="5866.A0A061CZE5"/>
    <dbReference type="GeneID" id="24562537"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103160"/>
    <dbReference type="OMA" id="PKLFAGY"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_bL28_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595289" description="Large ribosomal subunit protein bL28c" evidence="5">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="212" mass="24131" checksum="C7739D53FCFEC39D" modified="2014-09-03" version="1">MCLSLSLLALCVWLLIIATPTSCFRQSTAAPRDLSISRTAGGIVRPFVVFSEKRHKEALLGKKFRTVGRSSQKRHYRLVGRGGGIPRLHKVSGMPTKRIALPARRCMLLGKMDNTKARSISHSGKRTHRVQKVNLQWKRIWCISRGHYVRLRLSTKGLKTIKRFGLEEAARRFNLNLNNPKLFGGYANLKPKKPKKKIVDDNMFMEQIPIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZN6</accession>
    <name>A0A061CZN6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101790</name>
        <name evidence="2" type="ORF">BBBOND_0101970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766036.1">
        <property type="nucleotide sequence ID" value="XM_012910582.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766054.1">
        <property type="nucleotide sequence ID" value="XM_012910600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZN6"/>
    <dbReference type="GeneID" id="24562391"/>
    <dbReference type="GeneID" id="24562409"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101790"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101970"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="64" mass="7086" checksum="4A8579AEFFF3C368" modified="2014-09-03" version="1">MVLISHSDMHDDDGLPQTYGWLVKHSHYLPIWADCRAESCTTATNKLINTSTALLTAVLISLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZY9</accession>
    <name>A0A061CZY9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0104750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766352.1">
        <property type="nucleotide sequence ID" value="XM_012910898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZY9"/>
    <dbReference type="STRING" id="5866.A0A061CZY9"/>
    <dbReference type="GeneID" id="24562707"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104750"/>
    <dbReference type="OMA" id="ILQEMNW"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="2">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117497" checksum="6B5515C96D42C144" modified="2014-09-03" version="1">MVDKVRFAHVETASGAEDATKRAADLADKAMEMLRGGRIVTLPEPAQRSRSYRELILQEMNWMACDYYHERRWKVHAGKQLCIGIRDSVMDRKKLNKNWIASECTLHMKRFWAGIIANAQHHAAVSDELAEYCANIANKYNDQMHTDAGDVTRDYDVGERDLIAITVPVVKLQGPNAAALKVRAQKNEVLEATILSMQSMGADFYRPLFRPPDDEMDMFTMPLMDPARDNDFNALLVQSFCLKHSNRPRALPRAKSELKPPQLPQVIRKFHRKANEPSCLAMSARDFDIQIKPKPTFNGHMVKTQLTAIDFELLDSWMLSDAPSWPMLAICLTYRSSASGLHRHEYSTEYCREVFLKLSRQPRGLVNSSRRLLGPRQRNAITTFLDAPPRRLKFEPLVDCHNRNGSDERNSATKRQGLRGAYNYGRRASHIKPVSRKRKRRRSLKAHYMELLQNYRSAKRFAIRRSNIDDSAMDVDGESETTKMKAVSASSVHGKKKKRQRRHSIEVIEHEPANEVQIRLPFSSSAVKDVGDLPVAFLQRSSQPTHPGPVGHTSQQLTLLEEVPKDGARGEIIALPKNARIEVAITSGKKKMPPCHKSGREIEPVLHMPNVPYGEYSNRMSKQLRVGFLGIPAKMFAHSLFYSGRFCKNNRVRRVAVTIANSTKIMMPQPNMLYARLFEHDVVSIFGRFRTYNWQRTLDHPPDRHGEQLLKKYTTELANSSSKKLKPAPDTRAIEILAGYVSLKLSRGEGKQQGALGTTKILFKSIEQVDPITRQQHLAQFHNTPPPPPQPQQHMFMPPMQTMQMAGHGVSPHGAGQPMMLHPVMPPPMNMAPMPTPQMPHIPMHHGSMAQGGRTPGSATPGSMTPLPNGAGQMMPPTMQQGHMTPGSLTPRQMALMKMPPGTMVAGGMQPGQMTPVGMQPGQMTPVGMQPGQMGPGKIPPGTMPGMPPMQLQMQSKAAAMQMHLEQLKRRPPMAMPGKRRPMMAYEQMYQPQVAPPPFRYRPMPDVNMMRMPMYPMAMYNKQIPYPKTHDDPYRSPHMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D035</accession>
    <name>A0A061D035_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766387.1">
        <property type="nucleotide sequence ID" value="XM_012910933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D035"/>
    <dbReference type="GeneID" id="24562742"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105100"/>
    <dbReference type="OMA" id="YRYQELC"/>
    <dbReference type="OrthoDB" id="366035at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="24097" checksum="D181A531C17DC5D6" modified="2014-09-03" version="1">MVAYYDWCVYRQFNMLGSYIGYYDKFLENSTKDPLCHAQSPTRSLPSDCLKHVREPTKGGGDESSPESSSDGTDDNNNTSAFEHADAPKEQELLDKLREAEYAILSMQEHCDRLNRDHFDVEQILKKTYYENNQRNQLERSRLQSELEHKEQQLFELMRHQEMSNIFWDDRQREMNELMNDVILNVKDMYRYQELCNLFKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0K1</accession>
    <name>A0A061D0K1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0100060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765863.1">
        <property type="nucleotide sequence ID" value="XM_012910409.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D0K1"/>
    <dbReference type="GeneID" id="24562218"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100060"/>
    <dbReference type="OMA" id="QYCKRIF"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="3">
        <location>
            <begin position="805"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="2">
        <location>
            <begin position="1680"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1953" mass="217137" checksum="06B3DBD29CABC9E3" modified="2014-09-03" version="1">MSSAARLAYATLAEATSADAVLYGSFRYPGTDDVVIVQGRRLVLYTLLAAADDAFLPQDRYEPPSRMLSCKEDAIKKFGRHFVSESLRFVAETTLLDAPVATRVLHDCVLHSYRRVSPPVEAQPPSDAELDSALPSTSLEDASASPDCAKCESDAADPESESSSQAAPRNDGHIKAHTRDEFHATSALLLTFQHGRLLTCAFNVVQNTFVTLSMHALDRRVDLKDEVYYTSLPIRKKLRTVSVTESHVSVCEADGWRLMSRRTVSKQSFAVYGRRFLIAMCFNERIVQLMPIVFEFAWSVSATSHCYQPFAEHQDSMLRPGDADQHSVSLVPWIRAENLVGFDVDTKLGFCDDRYFVRGLDLVSHHGRCILGLLIATKPEIVGAHVIEGDDYAIGGMSYVGISVTCKSGFCSVVQRLDGLPMHTFEIKGVPASVYGTSGFMFRSLDFLMWVTAMSPTFCWQFVSPAGLLNTGFEAECRDRQFSRFLDAMYLNVDMSEYHLGFAGSSFVLVPRRCGKAYIGRPVCGYEGALCDIFWTKLGEIDTEVSATALARLGESMELLASGSGVDLARYSLNYPATFLEFELENESFERSCYPFEVDIVEIPTRVVFTKTRMREAFDSAIGEASLELQDSVANCGAVRDPKNVTLPELWQIGCLRLPKAGKSVEEIPINERVIPKFKPQRRPYAANCRQITEIGTVDYVWPKQQSLVGLCDDSKLVVLMEKYPLHSVISVPVQSGSTLIPLEYTRPQCPQDDAAQSEHSRDTRLLLTWQSGTCTVDLNADRFAIRSNGSLDRRQVMHHKSASEPAQLPISTDERTLCYGTVLGNRFAVQITPTKAVFIDLCGYTQVCSKALTKFEEPESNVWAAEVADNVVACLFRSGNAALLSVSEESGVPTLSVTRRISGGVVQHISLYRPRRVNSTFGELCLLVFTTMGTLFCYRMDTFERIFAFRGITQVFPRLFSDSSEELEITAVTVEEIEESTPTVTKAGRRRVGKRTRATLAADTLDEDTSPATRPKTRAKVTATRSKSRKVRQEPLESTEVSASEPDQPCATDIFDDITHLPFADSLNSAIERWNKSRQYEGTLEYVISIRMVDIAPTDLGPTLLVLMTGRPLLVYRSYLVSGTDYVFELFPHRFVNPIPSAYVDMNSASSPNQRLFMQLNREHNVGGFCISDPLLGRRKIDDLDKSDLNYVTVSYPQISADDVFYYSVCAESTELSSSAKPLSKSQLTSSSELSSAVETLTKRWKSFRPPCLRLTSICNRLRIHEYEVENALDMDTVIGEAESRVTSLYSIVTGEDEYSRCVVFLTHPGTLVLCVPGMLHQETSINGHVGLQELVAGSDEAEHLTSKRPSATTWNPLLCRLEFEDSRSVRANLFCRRLRENAGGIVFSGDLLSHMLPLGSLRGTLTAVSHRNYYLSNGMIRANRNATIATLPPVGDIHPVYCGKLVAIVVRTAVDAKEELTGVLNDRINLQLRQLESETLPPGTKPIEIIEPNKQICTLLQTMDLLPEDMTLSQPVWRDMVVVLHMGDLQHWYAEYRAEPMESILSVSFGIIGNREYLLVGTCTNLGENVESKGDVIVIDLQPLYQRQPCKDDGAASEGIKAIRRSGNCATLTQYCKRIFPGAVSFLSSLNTDFDLIFRPNFNFLEDLENIEKFDNAMIYGNEDSSRWTLSHFMPNYGLFVHSVGSRLFVHEVSGKQFLRGAFAEVPLCVSTACVFDKCIVVGDLNRGLHFFMYRHDAVNDSRTLCKIAATVQKVDLTVVACAPLVNMDALGLMASDYYANLLLFKSQSERNGRETLVVTAALRLPTRVTHFVRREPDFRHCTVPSAAVSCPCKHSNTVQLGFCADGSVLLTFMPESAVFDFFKNVQTAMDASVVPPLGVNRCSTPFFTSQMSQTQAVWPGDEALLHLDALRTLPFQTESYLSSLCRKISENSSLPSYQLLHALYGGLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D122</accession>
    <name>A0A061D122_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766707.1">
        <property type="nucleotide sequence ID" value="XM_012911253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D122"/>
    <dbReference type="GeneID" id="24563062"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108190"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28332" checksum="447215AA5ECFD0D3" modified="2014-09-03" version="1">MVYHSLMDVPCNLKEGIDWLIALKGNDAEKNIAAMGAAVYDFLVDKPVGKMNVPALEKVKLITKKFLATPKLMNLSFVQSMFEKFKRPMAKRPCLLAKMFRNFEHSDYENVLQTKKLGSEIVLKSVGKVADSCDRFLNHIKTTDSYTSAYSSEATWDASCAKDPEACAVVLVGIAPMLWAGLTSLWDATNPQAFGCGTALVDNRSRAMLNAVGYEESEYRNTLGRVNLRNALLSMDYDTLRILYYLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D136</accession>
    <name>A0A061D136_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0101360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765993.1">
        <property type="nucleotide sequence ID" value="XM_012910539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D136"/>
    <dbReference type="GeneID" id="24562348"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101360"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR93807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="12050" checksum="2ABBFFF5EC335587" modified="2014-09-03" version="1">MCFYHFKTAKEAAFYCPAPYVLDPPNCFNNVSVNGEVKDLGELSESMFTTRSNHFIILKFDSDNIGPGETLRQSPPLECRCITIKGVVLSTIQIENYYSKEWVAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D153</accession>
    <name>A0A061D153_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766544.1">
        <property type="nucleotide sequence ID" value="XM_012911090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D153"/>
    <dbReference type="GeneID" id="24562899"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106670"/>
    <dbReference type="OrthoDB" id="10533770at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="127" mass="14342" checksum="733B104612F05F90" modified="2014-09-03" version="1">MLNTPAIRQLSRCISLRSNKSQFPWIPTSNAFEIVTSVPICAESWPVYPCVGVNVINALTPTLANQVLRTPHHIGAQQVEFRRHRGGKVKNKLRNIEKRKKREQNMHRLSSDVKFNIRTGPADAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1E7</accession>
    <name>A0A061D1E7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA replication licensing factor MCM8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766649.1">
        <property type="nucleotide sequence ID" value="XM_012911195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1E7"/>
    <dbReference type="STRING" id="5866.A0A061D1E7"/>
    <dbReference type="GeneID" id="24563004"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107610"/>
    <dbReference type="OrthoDB" id="361400at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM OB" evidence="2">
        <location>
            <begin position="188"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="446" mass="49150" checksum="71601BA522ECF611" modified="2014-09-03" version="1">MELSAGVLRHLGYLYFTGDQTKDTGPLIKGITQWTEYFDFNWQAILGKGEEAFRETYVVHIDYLDLLNTDVPGGVEVFKHNICSKPAFLLSCMSAGLHISACKRFGRNSLIDKHLDGRNAGGDVSDTSASSVSLDAAGATDMQCKRSDIATTLLGNGLCKHVFFMDVLPQYVTLRLQNFFPRSPFSVLRSHAIGCLVSIAGQVIRISTTTPMIISGMFTCAKCGCHFFKKFKDGLFEYPSRCFTEGCTWRASHFQRHCVQTTSSQVVRIQEDSRMDTSASARYGDSAVGTYVDVELTGDLVDQCSPGNLVDIVGIVDATPCLVNEDLTGHNSTYNIVVKAVSMNVLNKRMTRFSQDAYGARGFRWGITNGIPDHQMNSRKTWKGLPTSAQTQDTNSVASQDDNATGDSGLYNFIREIYYSEPNRFYLAAASLCRAAVGRPYIKGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1M3</accession>
    <name>A0A061D1M3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAJOR FACILITATOR SUPERFAMILY MEMBER protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0108460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766734.1">
        <property type="nucleotide sequence ID" value="XM_012911280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1M3"/>
    <dbReference type="GeneID" id="24563089"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108460"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="527" mass="57410" checksum="B4019D552A495530" modified="2014-09-03" version="1">MAEGSSGSDNTSAQLDRKLEYGPLAKALYILVSFFEGYDQQVLSMCMRTFELTLGFSQSQLSTLATVSTMSRMGCCLLWGLLADQHDSNLILGAGLLVMGMASIFLSSASHYKVIVFLRFLHGFGFACVYPVQQKIVSDSTESKEAEDKRKSVTEKGTKGGAGSPGTSVTPTSPEADTAKTSKKKESKEASTMFTALQALNCIGRLLCAVITTIIARKVLLGYYGWRTSYVVLGYVWILFGIGILFGLTPLCRNEAYKSDENFKELLEDAFSNAFRRATTWILILTIFIAEAPMSAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSGAGGKIIEKIADLEDGFGELGCGIAVMVVRLVVCLLFFLGKPPCGKLLWYHYVELATLGGTLVTVGGVDRALLKSSVENKSQATASATVRTISGISSSIILFQVCAYLTEKVFGYVPSRESFETMATDIKERNAEALRKSMMYIILAGTLLNVVCYVVLFFTYKMDKKKVDENNANHKKKVEEKPKQLQEGSQKCMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D233</accession>
    <name>A0A061D233_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hexose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0110990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766987.1">
        <property type="nucleotide sequence ID" value="XM_012911533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D233"/>
    <dbReference type="STRING" id="5866.A0A061D233"/>
    <dbReference type="GeneID" id="24563342"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110990"/>
    <dbReference type="OMA" id="HWIPVNH"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595686" evidence="7">
        <location>
            <begin position="17"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="4"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="579" mass="62354" checksum="F93BA28B5EB9195C" modified="2014-09-03" version="1">MAWYFWAALLAAGIVAFNFGVICVSLGPSKQFAFKEMGIEEKRHCGGKQCSKDNNELSRILISGAVFLGCAIGSICIGLLSHWGRRKCMILIHLLSIAGCGVAAIGKHWQLFALARLSAGVSVGMSGVASLYLGEICSSDKRGLYGALYSVFVTLGELLISLWQLSHAGSLDSLCTCDSCCCNKDCAERKCCCKDGKLCTNSENCCSCTGSNCQCCCATKTEATKPVAARPEAAKTATAGCGGKLEADKSSDKAIWRMGQLYGALASLVALCLLFMVVVDDTPFMLVKRGEHQKAKEVLALLQGPDKVESSFQEIMEDVASEESGAKKMGLWEALSYPDSRRALLVVFAIAILRQLCGIYVFTLSASEMFGMIVGQGLGATAMGNLCPLTNFIVCCLLPLYIDKFGRRKLLIYGSGIGTSVLAVCLLLNTLCGDGEESSNSCRKDSKKEARWPQYLMIFGCMVFVAAFATGYGGVAWLYFSEALGAEYRDAGFAVASALNWLAAALVVMTADKLRSVLSKNVYWVYVFFSFISCLFAIFFVRETKGVPLGQAYIGGGSPWSMRGTPEPDPYDWPHVIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D277</accession>
    <name>A0A061D277_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766904.1">
        <property type="nucleotide sequence ID" value="XM_012911450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D277"/>
    <dbReference type="GeneID" id="24563259"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110160"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="7822" checksum="F8009F134B1775DA" modified="2014-09-03" version="1">MPSIRQRHSVTASKYHDVCALRTASVHHGVSSDITTNHHAYDKLPVTVSPSSHPIGLPWRQPPPRPSVPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D290</accession>
    <name>A0A061D290_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766914.1">
        <property type="nucleotide sequence ID" value="XM_012911460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D290"/>
    <dbReference type="GeneID" id="24563269"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110260"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="8409" checksum="EB4F8869A908FCAE" modified="2014-09-03" version="1">MLAALRLGDVISHYNITLTSNGYTSHNIIYMRWQHDSFYMREDRRIDRFDRPGHFSIVFLANIRQGVGHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2L9</accession>
    <name>A0A061D2L9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition motif containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0201830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767212.1">
        <property type="nucleotide sequence ID" value="XM_012911758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2L9"/>
    <dbReference type="STRING" id="5866.A0A061D2L9"/>
    <dbReference type="GeneID" id="24563567"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201830"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="242" mass="29036" checksum="ED4E762006BF4F0B" modified="2014-09-03" version="1">MEGDKPTGYSLLLRNLRYSTTTQLVREAFERFGKIRDVYLPLDFNTKRPRGFGFVEFSHEADAMEAVKAMDNAKLDGNVITCCMAQDRRKSPNSMRRAYNNATPGRRYDFSPPNARNGQRQDYYPGMRSRSRSPAARYSRRSPSYDRRYPPMRDDYPYYYRRDHDRSPQRYPRHYPPHSREYRDHRPEYMERDARRYTVRPPHIDYARPVHERRRSPPRGPEPEELSPDSHDMQARRPPRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2X7</accession>
    <name>A0A061D2X7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0201250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767154.1">
        <property type="nucleotide sequence ID" value="XM_012911700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2X7"/>
    <dbReference type="STRING" id="5866.A0A061D2X7"/>
    <dbReference type="GeneID" id="24563509"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201250"/>
    <dbReference type="OMA" id="YYYVFLY"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="498"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="658" mass="74171" checksum="A422116DD83A6718" modified="2014-09-03" version="1">MKNIGNLNEASTCVSSNIDTSDTNGERSAYSYDSVPAENGDDYYISAETSIVSAATNKDHDALFRILKPMLDKNDVSHLDSICALHWACYCGHPELVETLLNVGCDPHCPDDINLETPIYFGIRGSNVQIVQMLVQRFGTELLCHENRKRLTPFLLAASEFLEDNVISTLHMLEFLYLSGVSLEEQDASGRTALMLASRRGCQFVVQWLLSRGANLAHRDHMGNTVLHHACESGNDETLRFLCMHGGIGLVHSKALAATANEETALGICLMKRRFLQYSMLKIWSWQYALTGRMLVFRTPHPLYFWTGGIINLVLYWRIYSTLETATSMQAALVDVWILGWIASYGFWIITSASDPGKARKNPVMSQSHRTSANFENDIMKDAPMLGGTYEAQLQSLQKQQELINYELYRINCEAYRLNSWVPHEDFSGELSEPLDPCGYAGEDGMAQRMQVCREEAQILQTEMHALYPQVGVERQEHCVFGYADAVMGSVRDLSISTVCITCNMIRAARSHHCGTCGVCMVRQDHHCAWLDNCVAKGNQRAFAVFVSSVCIGLCHTYYVVYLHFAAEYARMKFDWAWDVPIILFGVLVNAACLAFAVRLCLRISRNMATDVTFYEYLRKPEHIRQRFKGQVEGKFWDFADMSLLKAIANCGSFWVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3I3</accession>
    <name>A0A061D3I3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRKR-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766823.1">
        <property type="nucleotide sequence ID" value="XM_012911369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3I3"/>
    <dbReference type="STRING" id="5866.A0A061D3I3"/>
    <dbReference type="GeneID" id="24563178"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109350"/>
    <dbReference type="OMA" id="LMEKKWK"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="21805" checksum="A8FC78ECC699C631" modified="2014-09-03" version="1">MEQHAQNEYVTLADGRRVAVPLQDSQQNLDENDEVQIERLHNVWGSSSGARSDFLGIYCKHRNNEHERLKNQDEQWEQETQNTIFQTIRLTRMQKESAKTAKRREKRNKKKVNKLMHTDQQQKKQHSVVQPQPGKKQPDSGADNAGGNAEYQAPNAVQEGVGPMSTTAHTHEHKTCENVKRIVIEDDTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3P4</accession>
    <name>A0A061D3P4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766878.1">
        <property type="nucleotide sequence ID" value="XM_012911424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3P4"/>
    <dbReference type="GeneID" id="24563233"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109900"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="6490" checksum="B2620293B101CB2C" modified="2014-09-03" version="1">MRRVRCSYGILGSVGVGGLGGGIQGLGLRGLGAAVAEGSGSGSGTCCSWLRGVGGEGEDGKGFKGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3U4</accession>
    <name>A0A061D3U4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767429.1">
        <property type="nucleotide sequence ID" value="XM_012911975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3U4"/>
    <dbReference type="GeneID" id="24563784"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204010"/>
    <dbReference type="OMA" id="YISHEIM"/>
    <dbReference type="OrthoDB" id="364817at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="480" mass="53083" checksum="F1A96E77D5B73C20" modified="2014-09-03" version="1">MAELSDVYKPAWHAKFKVLFKTGTFEKVVVLIMGISIMQPLHITVAGAAFSVRRFGLGPESIGAFLGITYSFQQLFCLMGSLTSTILSLTLGEKYQQYWIYINGTYSMVLCVFITMLNTRLLLLCATSIGDSNLTAYYWTLAFSGYLFGALDTPVRQITVGLGLYFALGQAFNGFCVNFVHAVVPKFISPTSDVHYWTIYWQILFVTLLSMVAGILWTIFVIFDKFGPPKPNYGCRRGKGPDFVNALQSGMINIFLVCGSLGTQFCVYPSIAPFSIVTPDKAQNVIRACLYLNALVGVAGVLLKEYCNLGKAWDAKNSNAFYNASPFLFVPYFFLFWLFIYVMHHPKSFIGSMIYMKPNVVFILTVAYFLIGGLLKTAGFGGAFANMNFGKPGDGKGAGQAMAFLGTSVMVTLVTTKFIASGYLRAVRAAKRGLDSGLPWPTEDMSEVRAFFYWLKLGIIGAGKTLRDVFTTDIRTKILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3V5</accession>
    <name>A0A061D3V5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0205540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767582.1">
        <property type="nucleotide sequence ID" value="XM_012912128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3V5"/>
    <dbReference type="STRING" id="5866.A0A061D3V5"/>
    <dbReference type="GeneID" id="24563937"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205540"/>
    <dbReference type="OMA" id="NCYSSFP"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="111"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="287" mass="33743" checksum="2727B384E676FE1C" modified="2014-09-03" version="1">MGGLKSPIGRFLPVCFMCLIFFVVYTIYVEFVCIPLFQLDVDEQYRLFNKQKEGYRQLVYFHVLALLLVWSFVMTAVTDPGYITDAWKEDETSIYSCKERGENGTYASLREFRYCKKEGCYKPDRAHYCRQLRRNVLKMDHYCPWVANCIGFYNYKFFFLTLLYSNTTCCYILRNVYNEFIKLYFDPNSPFNKLFYLSLITILMLVIIGVVLPFMCFHIWLILSNKTTIEFCEFQASGTYNYNLGALENFKSVFGSNALYWFLPCGYPAGDGLHFPGMFRCLSLMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4A3</accession>
    <name>A0A061D4A3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767757.1">
        <property type="nucleotide sequence ID" value="XM_012912303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4A3"/>
    <dbReference type="GeneID" id="24564112"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207270"/>
    <dbReference type="OrthoDB" id="345870at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="467" mass="53253" checksum="6227147080B36BD8" modified="2014-09-03" version="1">MDSDWEAEDVQSPRDGSGGEAPQQTQTGTHLSRIPNQSLAESEGGGDMDGNAAETSKNEDELPEGWVRHGKGLMLEVPITPRMIASERNKLPPPHFKFTADTNRRSAGRLQAALLHIDRDAVRRMKNEQNVRVRAARPASDGQEADTSSPMRTRDASMRCYRSLRENQHTASPISRAKGEEQFDRKIAFMKKEHERQLIEAKRQVLEHVDVLIKKYRQLAIDAVKVAREEQKKAEAERRNTFEACARYEAELKANVRNAIAHLKLSSQAEHDRIAAERDALQRRCADMTPKAEAWKPALDRITAQLAAKFKGNQKFTIGIIDDTRDMIIDEFHAFKASTAELMVQKFVANGCDLQNQEAEQFVEHVLMASGATNRSVCHDEQEHQRQWEQQRLQKNIHRTRNHVSQEKEFDRVLADAFHYGDVHVHLIRVMAVMRERTRVLELGKPRRKSANDADAHNIPILIKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4A4</accession>
    <name>A0A061D4A4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767063.1">
        <property type="nucleotide sequence ID" value="XM_012911609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4A4"/>
    <dbReference type="GeneID" id="24563418"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200340"/>
    <dbReference type="OMA" id="VTIKCEY"/>
    <dbReference type="OrthoDB" id="361113at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="746"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="863" mass="96622" checksum="AD6E4A174E4D39E7" modified="2014-09-03" version="1">MAATSDVIGAHIKQLQNRVLVQHAPTVARFKRREIDRQCHDLQTMDACSEYTLLAPTSDNGLVGCLNSCAVFTMLEQKPVKKRQGLTQAYSVLITLKCEFVNIRDGITKYLFQVLADHDACNHGYFHNIQVNQNGSLLLLTAASAVYVARIPTEMDHDNVVADTATRALLYSCIIRAERVLSRSTGWRRYTPLKVVKARFHQQYANTVCLLTMEPKSDAAQSAEGGDNDDAKEKSPDGVLIGGASESAGNCHDGDAQMLASWPHTPLNVEMQGVVRIYNVEQSIDTPYMTIKLTEGMCRTGDENAEFDPDAIPQGSVVDFAWVAEGDLTWRTMTLLVMSNYGMIFAYCPILLPACINTFSRKKGIMNLSLDLMGKGYRMKAAPQMDRLATHEDVALLMGSLANVSQSKDAETAGDEVVVEPSVYKLQTEQTVRPMFEAMIVIDTEPELVVLASASNGQVTLYKSTTPVAPRTSHFSLPGTKPGLTQLQVDGDRKQSARCEARVSLIRISENTCLAHSVMGTDVLTIHAEGIDVKSVVKTRSAGDHVYYHSQPLIVAESGHKHTYHAFWDTWCDVNRKVYMLQAKYCYLVSNQELRHMATSVGTTSFLDRSYERKTTDEPLRRVEFPMVATVRALIASPPKVEPTPSKSQPINSSIQKLLQRAAEAETFSKQAFKDARELVKKNSDFKTKAVAIVKVLSEVDSKIMFYLKGRKAFEAALGESIEAYNKLHSEAEKVFADLPAFHQRVQDLRERAQIIKRNNADIEERQRRIASMKQELRQSGLNDASVQQLADFITHVYIKCSQNMCKQIAYRVNQDDKLYNYKECVKRVIDQWLAETLNSNIETMEKTFARIQNIRNRIIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4F6</accession>
    <name>A0A061D4F6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0207710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767802.1">
        <property type="nucleotide sequence ID" value="XM_012912348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4F6"/>
    <dbReference type="STRING" id="5866.A0A061D4F6"/>
    <dbReference type="GeneID" id="24564157"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207710"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00677">
        <property type="entry name" value="S15_NS1_EPRS_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="151" mass="17369" checksum="9C14D287D0DE7FEA" modified="2014-09-03" version="1">MGRMYGKGKGISSSSVPYRRRPAPWVKTRPLQLEQHIVKLAKKGMTPSQIGVVLRDSNAVPMVKAITNNKILRILRGHGWAPDIPEDLYFLVKKAVVMRKHMEHNLNDKDSKFRLILLESKIHRLARYCKKKRRLPANWKYKSETASALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4H8</accession>
    <name>A0A061D4H8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0101680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766025.1">
        <property type="nucleotide sequence ID" value="XM_012910571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4H8"/>
    <dbReference type="STRING" id="5866.A0A061D4H8"/>
    <dbReference type="GeneID" id="24562380"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101680"/>
    <dbReference type="OMA" id="HAENKHL"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC-A/B" evidence="4">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR93839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="201" mass="21920" checksum="016068CE311450BB" modified="2014-09-03" version="1">MSTEVVEHVTPDMLAARERLRARMGVSGTQTGGKGTARRKVKKTSKVVGDDKRLQFGLRSIGAANIPGIEEVQLVKDDGHILVFSNPKVQAAPNANTYVISGLAEERELSLPDIIQQLSAAGFGLPSTSRKDEDSDIPQLVEVFDSVAEKDEERENKIEEVEDDVEEGDDQTAEEPADQDVQGDEPATEAPPKIEEIIEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4J9</accession>
    <name>A0A061D4J9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0101930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766050.1">
        <property type="nucleotide sequence ID" value="XM_012910596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4J9"/>
    <dbReference type="GeneID" id="24562405"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101930"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR93864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="11364" checksum="20522569C04C850C" modified="2014-09-03" version="1">MCFYHFKTAKEAAFYCPVPYVLDPPNCFYQVLVEGEVKNLSDVSQSLAALHSNHFVTVRIYSSVVGPYETLRQTPPLECRCVTIKGVVLSTIQIEHYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4P1</accession>
    <name>A0A061D4P1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0102430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766100.1">
        <property type="nucleotide sequence ID" value="XM_012910646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4P1"/>
    <dbReference type="STRING" id="5866.A0A061D4P1"/>
    <dbReference type="GeneID" id="24562455"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102430"/>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="11">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="198"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="415"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="688"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="820"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR93914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1120" mass="126576" checksum="D231BA7AF491D145" modified="2014-09-03" version="1">MTTLHSLEIRGIRCFSPNATQSIRFEKPLTLIVGHNGAGKTTIVECLKMAASGILPPNSDRGKSFVHDSKLSDEREVRAQITLNFETPSKEIVCATRNYITTRDKNIPNKSTFKAGETILRVKPPVGEESRVSMKCSDMDQSMPSLMGLSRAFIDSVIFCHQDENNWALDDLAKVKARFDDLLETSRYTKAISALNKAKKEQEEAIRLNAAKLEATKNQIIQIADIKKQLNSNVEDVAKANANIATLEKDLIRFNETCKALRAEHEAVSATFAALRETNSNVERLSEEIKTMHQNMSEIYEEGLDDMHHYHLTLTNELEAAEAMHDEVTRTIDQLMERMNTLHQKINLSKNKLTNRALLEENVKVTAEAKTSVIIEIKKEMALDGDTEFNEESVMFFIEQLDSMNNDDDPINKVFKQCKEDITELASKIRDLNEMEAKQSLTTNVHADELAEIKKKIISAEQMRATLKQREAMKQGLCLQVEQHQQHFKNLVDERDKLKIMASKLKNAISGTTIEDENDLRAAVNFLEAVIKNDRQLILTYVRKNISKDIDDSNFSEALRDIFSKYLKGAKQVPGAPSNALEDPQQFQQDCVTAIIQMITNVEGGDLCMGDEVKTCSANLEPYNPLLKLVTNLRISEYIAYYNGLLNKNSEVCSAEDVTYEEVRNKLGAKEVEITQVESVLQGTKSSLVELEAECQQLAAGIGELKELKSKLAEMQADQKKYNAELRSIRSALEKSNAQLIDKQQELDDASRKISAANTANAVKAAKLTGLLERYREYNIKLEQLWKEIEKLSEDDQPDDGLQVELNGLTENINRSRVEQRDLMNTLTNHRQLLEKLQQNITLKLKQNQLDEQKQRLDAIQQKLGATKEDEIAKKIKQTSEQCTKVSLDIATLRGTVITREDNISKLKRMLDSPAFKNAHKHYSDALLAFKSHQLAKDDLELYTKTLELELHKFHSDKIAQINVVLKRVWREVYTGTNIDYIEIQSNDDTTVASTGMVMVTHSGVEMDMRGHCSAGERVLASLILRITLTESFCYNCNILALDEPTTNLDKDNIVSLETSLAKIVSESSIDFQLIIITHDEPFARKMALRCNCDKYYKITKNDKNESVINAVPFGSGFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4V9</accession>
    <name>A0A061D4V9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="16">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BBBOND_0207580</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="16"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767789.1">
        <property type="nucleotide sequence ID" value="XM_012912335.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D4V9"/>
    <dbReference type="GeneID" id="24564144"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207580"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 16 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="18">
        <location>
            <begin position="234"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1479"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1547"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1625"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1487"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1547"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1565"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1625"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1704"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1716"/>
            <end position="1758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDR95603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1771" mass="197330" checksum="C1F15EFCF46C92B3" modified="2014-09-03" version="1">MTTVAELNKPFSPCDLKKVRAIEFGVLDPEMLKRLSVCEVTQTEFYREGIPVTGGLNDLRMGTTDARHNCLTCYMDLKHCTGHFGHITLSKAMYHSSFITAVMKVLRCVCFNCSSLLCAKDDPRVIQIMKLRATALRLNRLVEVCSTSPRCQHATLAGSKMKGCGYPQPRYSKEGTSLLVQFTEKHRQMLEEVDEECEEIKRTFTADEAYKILKGISHEDMRYLGFNPERSQPAWLILQVLPVPPPPVRPYVAYGSDRSEDDLTLKLLDIVKANNMLKKHDERATAPHILQEISQLLQYHITTLFDNDIPGMPVASTRSKKPIKSIRARLKGKDGRLRGNLMGKRVDFSARTVITGDPNLPIDIIGVPKSIAMTLTFSETVTPLNFESLRSKVEMGPHEWPGAKFIVRDDGTRFDLRHVKRASDLQLEYGYRVERHLQDGDYILFNRQPSLHKMSIMGHRCKVLPYSTFRLNLSVTSPYNADFDGDEMNLHLAQTHETRAEVKHLMLVPKQIVSPQGNRPVMGIVQDSLLGISKFTRRDCFLTKDMLMNLLMWIPYWDGKLPQPCIFHPVPLWTGKQVITIILTFDQLNSLTCINLMRNSGTSIENDNPYCSANDSKVIISKNEHLSGIICKKTVGTSSGSLIHVLWHEAGPERCKDFLSTVQKVVNNWLIHNGFTVSCSDIMASESTLAQVAEILDRSKKEVQRLVGLSQKGKLKCQPGKSLFESFEARVNKELNEAREQSGTIAAKSLDERNNILAMVNSGSKGSTINISQIIACVGQQNVEGKRIPFGFRDRSLPHFIQHDYGPESRGFVSNSYLSGLTPQEMFFHAMGGREGIIDTACKTSETGYVQRRLMKAMEDIMVHYDKTVRNGVGDILQFLYGEDGMGAEYIEDQTLDLMKLDFAELNRLYAHDFRNENYGVGWILDETIRNNILTDFSQQVVLVEEYQRLLDMKSILCKQVFPDGETRQHLPINISRLLEYAKTQFPMTPESRKLMNPVDIAQRVQQLLDGLTIVVTSGPQDILAAEAQENATILIKAHLSTALHSRRLMEREKIGNLALDWLLGEVKRIFYKSICHPGECVGAVAAQSIGEPATQMTLNTFHFAGVSSKNVTLGLPRLKELINVVRNVKTPSLTIHLERGVAHDQERAKDMQTRLEYTTLDKVVAMSQVIYDPHVSRTIVTRDYNWVREYYEFPDDDMGRLGPWVLRIQLSNKVMTDKRLTMKEIVDRIYQEFSHDEIDCINTDDNNDELVLRIRVKYSSMEVDQQNLGENEGEFLQRFMSQVLVNVKLRGVAKISKVYMREEAQIKYNESNGRFERVSQWVLDTDGCNLEDVLPIPCVDAQRSISNDISEIFHVLGIEAARMALLRELRAVISFDGSYVNYRHLSLLCDVMTQKGHIMSITRHGLNRADRGPMVKCSFEETLEALVDAAVYAEVDNLKGVTENVMLGQLCPMGTGCFDIMIDEEKLRDANQNLQIVPDSAMSGFTSPDSTSPDSMSPAKINSMLSPLPFSPSYAALMMSPVINASSPGFAASPAIDTKALGGSFSPTVMSPQSPASPGYAPLSPNPLSPNPLSPNPLSPTMGMMSPTSPVYSPTSPVYSPTSPVYGQSAAVYSPASPAYSPTSPVYSPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPNLGYSPTSPVYQPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPEYSPQDPFSPNPFEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D528</accession>
    <name>A0A061D528_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase, cyclophilin-type family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0103830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766255.1">
        <property type="nucleotide sequence ID" value="XM_012910801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D528"/>
    <dbReference type="STRING" id="5866.A0A061D528"/>
    <dbReference type="GeneID" id="24562610"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103830"/>
    <dbReference type="OMA" id="WSSHCPK"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="435" mass="47935" checksum="64D700754C9ACA55" modified="2014-09-03" version="1">MSEVYCLEPPCRGRVILHTSEGELDIRLWSSQCPKAVRNFVQLCLEGYYNNCIFHRIIPQFMVQTGDPSGTGHGGESIYGEPFENEIMSRLKFRYRGLVGMANTGGKHSNGSQFFITLERADCLNGKYTLFGKVEGATVYNLMKIGQAEVNPANDRPTHPPRIIRVEVLANPFPDIQPRLLALHEQQGDEEDEQPAEKEVVSVRKACLLSFGGAGDSDDEGAVPVRIGKKAKSAHELLQDPKLSKQSVVLRDVERAGAAEPATARDAPEEGHDESADEQSQSSGDEADDRRREIEMLQSQLRSKKRGAETALKGHDGASYMTRKQMKLSGAKPNVMERFAAFTKRLGKLTKDSALAAKAQQETDEDLADGSWFAGRKLQFSVDSVKAYEVDAAKDTLTVFDPLQGKDNSLGRLSALRKDGTKGHPGGGSRDRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D594</accession>
    <name>A0A061D594_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mechanosensitive ion channel MscS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0203700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767398.1">
        <property type="nucleotide sequence ID" value="XM_012911944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D594"/>
    <dbReference type="STRING" id="5866.A0A061D594"/>
    <dbReference type="GeneID" id="24563753"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203700"/>
    <dbReference type="OMA" id="NVLYMCS"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="8">
        <location>
            <begin position="661"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="837" mass="95984" checksum="BA7E1D8FE846D608" modified="2014-09-03" version="1">MEVHFKTRMDDSGVKPYMRAESSDTGKETATSQASDTVEEEKVRPVTPIEYDESDDPLLNTNWCRPLEWLAHEFLHDSTALWIFAVHVSVFFIAICFGPLTLPLRAKFSSSMESFLSESMVVDSVEAVDMLNDNLSHFQTIRNGLCFLLTTLAAFACTLVGVMSVRYVAIKLLVQPLFYISRLAVVVTYAVDPAAAYCVWTIVNYTLFRKYTVPVYDGTSLLYYRFEIFGESFSKLHEIDLRCYAWANSAFQLLILISMRKLVLSSLLFLFEVSFLPNYSAELRGFLEDQAMLRRFNVAWLNYVNAARDSDDPIVIERLERARRAIDKLPMPETPIIHNHQVYYDAKHFTIFRPPIHCWKFRKHNCADMQHKVNELPQFYKKRWIKQCLTNVLTNWSALHYVVHNPSELLFMDYYVPLVSKKTVEEYSQLLFDHIYETMAALDHPDVVRALSGQQRRFLVVKPAAYESGASTSTLDMPIDRSVSRRTQRFAADPLIAKAHTRHHSIRMASNGDDSDVASADESSTDYHRHNSKLRRSDTDNDDRRFITPKMFSQLNPSVVEAFFVAYDIGNCGYVSSEVFTRNVLYMCSLRKRLMSALKNQRSILGLVSRLLSTALWFLIFVVFLMTFRVNKNIVLPSVIGFFSAMIVALSYMYTSFITAIIFVVLSNPYNVGDRIRIDNGEAMYVKSITTYNTEFRCVHEKVIAYQNSVLSTMNIINETRARHASTEIVLKVGASTTPAALKQLVENVKSFVNGHPREFVRDGCFVYGSEVQVGHYYMVKVLVTYLDNWACPKYIFKLQNKVIMQLVQQCNVLGITYKRPVAPVQFSGTLSYACRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5B0</accession>
    <name>A0A061D5B0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0104630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766340.1">
        <property type="nucleotide sequence ID" value="XM_012910886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5B0"/>
    <dbReference type="STRING" id="5866.A0A061D5B0"/>
    <dbReference type="GeneID" id="24562695"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104630"/>
    <dbReference type="OMA" id="PCTRIHD"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="290" mass="33601" checksum="5BCEC1C2189FFF42" modified="2014-09-03" version="1">MDEMRAQWEALMGNLENPADPKETKSFEDKDVCKMYLVGLCPHDLFENTVGACLPILTPCRSITSVRARCSTVTSCERSKHILYLEQRKTRYYNYEAETLRFIIPLIEDCDRRVQRGRVRAEDDVACKQTTLDDATIAEAKRIDAEIEKKMKIANELGEKGEVEESFKLLEEAELLKKNKLEMLEKAGETSYQSRIKPCDICGALLSATDTDRRLTEHYSGKIHVSYQKLRDMSKFLTEYIKEHKPDRRPPNRTHSRSSRSQSPSSSRSGNSGRGRRHRSRSRDRYSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5E3</accession>
    <name>A0A061D5E3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768117.1">
        <property type="nucleotide sequence ID" value="XM_012912663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5E3"/>
    <dbReference type="GeneID" id="24564472"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210810"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="83" mass="9363" checksum="0371E6AD0F7F9B92" modified="2014-09-03" version="1">MKDDKNVLGKAWLKFSQHGNTVKHMSMDYFTDNVKSQSAIYDPVIYSIVAYSCSTASVTGQSPPDTTQPKKNKERSTLYQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5F1</accession>
    <name>A0A061D5F1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768127.1">
        <property type="nucleotide sequence ID" value="XM_012912673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5F1"/>
    <dbReference type="GeneID" id="24564482"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210895"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210895"/>
    <dbReference type="OMA" id="YSYICDP"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600069" description="TPM domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27130" checksum="ADA3D5B4687A7E6B" modified="2014-09-03" version="1">MSAPAWLSLRRDIFTLIVLAWFVADALPRKVAPAYMLELGALPDVEEMLPEEEPPNLWDYSEPLVKNATTLENYPDPLVNPKECNRPGVRESYICDPDRILSEVEADRIDEVLSLQRDSSSHHCEGLGEVPVRLGVAIINWLPEEDMHTLAKELLERWRLSHDKCDDGVLLLFVVSHNTVVISWGKGVEPAINARAVSSISAICRDMMEREKVSIAIDRCTSFVTKRLTGVILPSQETNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5G4</accession>
    <name>A0A061D5G4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767458.1">
        <property type="nucleotide sequence ID" value="XM_012912004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563813"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204300"/>
    <dbReference type="OMA" id="INIGCEC"/>
    <dbReference type="OrthoDB" id="366359at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595994" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="887"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1849" mass="210448" checksum="2AB4A25018C265E5" modified="2014-09-03" version="1">MRLFGSLRRRNICFLVFYLRIINIGCECFNTEVDRSFDSPDILTTRALGAKQWFQSPIKIKCSFQTGFPCTVYPLDYQDASNLTLLCISEKAKNGAVLTLNFSCQNYAPWKRLSNLYCSVYKVSTSTKSLTTFIDLLPGVPEEIALCLHRLEENKEKTVSCKSIKIIFFVEHFAIKGSIYYLLKHTWKQMMQIGNSKHANKKTQIGILKRQTIKQKSDITSTRMEKDVDCVISESSARICDIEVVGNATLSYAFDPIHSLLWIQVSATHYNGTKALLMKIHNRETIHGVKRKIIIFLDGVRLGALPMEIDISKYISDSIEDGRECRSISLSTLNEESGRTNFIQIRLVKGDAINNQMATIHVNSSEARFMKIEGSNYTGLVYERDYSNRKPCLHIIRDMITEMSILINSSKPAVVTLSRTSDKVEAFLNGIKVKSREYPILMGSGKFVVLLRDSYYQKTIRLSYTSVTNYCNISCVTWCFYIYSHLMLGGTSGFVDSLVTYKFSSFLFNMDDVVLWGRFLVRPMLLFVKDMYTTSAFAELLLLNLVGLCCIVAVVTLRCFRVVNIRCRYKKYLSLLGMLCGLICVSVATVHSRVFAEEVGGIYILGYHLPYKFLRLASLAGLITYTASTFWLLFAAVGLSSVHTRISCSQFPHLRQQLMESRKGTAGYEYFIEGGKLYKLYYNLMQSRMPVDDLSSGRNSFEMEVTKVASVTLNGNHSGSMAPLFTINKVFKEYEDMPLTSLITLRDLEAMSLMRKKVRVWCQTKKNGKYINGEDAIDSLYMCMTMVDCCFAIFALMSARILIHGITLVVCHLTFKIAIIMVAFYLRYNQVKYLMHKEAIEESIPLQKMVKGDILLLGLVNKCVRIVVLIVLFVIQNIYKGVKTPTLIAIIKCCLISCAFATNFPDFRVCLSDGFKLLPKAALTCYYYVVSVYRFFKCRYRYKLFCYSKRSEVFRSSVAGKSIGIRSMRSHSSSQAIPVCILDLRVLDQFKNIYRFRRPRIVLKNVFFHPSVIAHFGDFIPTFEINGAEKDGVHNVCGGERTHSEGFPMHNTTELEPKQSPVKSMFDGLETLGYDFGHVLPQQISNVGLIDQKLDGKNHGSLSSALSEERALHIVHDNKTERHGFCFKHRVPLFQRLFAVIEWRPTIQSCISTTLKKCHDTIQDNTSRLVNVYIGIGSLSTVPPARSTDMLNYVKYDSHHNVLTISDHFIIPTEHYTIRGMVRGNHIPISTSIIYHTSCVENGEITFDSIQEIDDKMAIRVTEKPSMESSALLPSDLTIDHNINTNRVKLGNSIFKANRDYIITYQTEALDQHTCFIYIGPAERHFKEIVTPVTMSPQSSYDFVIIDKTGSSHTIYAVKYEQMTNTKHIFGMKSKVINTVEKIELDYPGIGRGHYSGYKFHITDVIDDGYGSDTPSTISRMLRVKPCQYILGDNMSFLVPITVVCRVPSQAEEDTFRVVPHYDVLQRDIECRINDLNIALQVLQFHLKLATSNETYGDKSILQYTENRKQVIQNICRYPEEKDMRQLYSDSCQDPDEIFEKVLASLFYDDALEDFWLQLNNQNHMDNGLLSSLRIILHCCIDQLNEAAGILMQQDALTKDVTLRMEMQKFDSLVSQGMTVEDAKSLLDNSEQFEYFLQIPFVLRLHDIHSRVDVNQEVTRMMYEVKQFCDNSKRPFLHHRSFIRDCLTQQLVSNVNLAEMCEGFSHILLPSTKSADLSVSNIYCFALATSSGNFESNSSALWIPCFISLKKGLLRVDPSDRIKEDERIGNYLESVICSMKCSICTDTIEVAGGLHVSDEQIQVVAHVVECTNTNCKVSEYSIVDNGAVIFRCHRSMKGVWQSISNAFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5L9</accession>
    <name>A0A061D5L9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exosome component 10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768207.1">
        <property type="nucleotide sequence ID" value="XM_012912753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5L9"/>
    <dbReference type="STRING" id="5866.A0A061D5L9"/>
    <dbReference type="GeneID" id="24564562"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211650"/>
    <dbReference type="OMA" id="DEMWRLN"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="316"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="814"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="933" mass="101498" checksum="19F77E85B077B345" modified="2014-09-03" version="1">MDLFVDYLDSQLQSPEDYDLLVSREESHRSVKSHLNKLISAASDAAKASNLLPTDDEYSIYVNNPAFSSRLSELSAKCAEAFCCVDPLFRKMEMDDYDDPCSYQAMEALSKEISLGLNVHHNDPNQRISAFRRDSGGKAKRKVPPKGIASRKSPEPPESSLQCDPEARLEQLPLEIDVDLYKRVCNHQQSRWAHLIDNFSLSQMSSHRRPKFNPIEPCVTKGVKLSEPEGPPTSDTGVQRRFVPMLYPTGDYLENYQCNKARAAVLPHPYTAEINALEWSNTEQEHSHRGRKTLGGGSLLDPKINVSGPSTPCKDCRMVQTLPELESMIAVLKGCNIVAVDVEHHSGQSYRGFVCLVQITGAGVDWVVDPFEIFDEMWRLNEVTTDPRILKVMHGAESDTLWLQRDFGVYIVNLFDTLKAADVLGLPCGHSLSCLVKYFLDVHLDKSYQLADWRVRPIPSDMLTYASADTHYLLDLYSALKNRALELDAQESAAGGIGCADNRIMRIMFRSRKVSLCQYKEHAFNEVIRSLQALRKCRQSLNRVDHLSLNIMMNLMSLRNYAARVLDESEQFVLPDYGAVAMSLAGDAKNASEVFLRSATKRMNMLQHEIPYVVKLRNTMKDALSWLDTTGEDLSEPIPLATVIDRMRQPPRSASPPEKTSDSATHAKASKPKRGDKGRSRSDSGTLLGTGPKPSGSAPKAPSTLGGTVEPTGGSGSIYAPFSSVAAQAAGSVPPSSANVSLNSRGDNTSSGGVPSDDVDTTAVSEATASAGSGDISVTAAKDKGSAKVAASAAKLKKRRAKRRLRPSQSTQLAADAAPDAATQPAAVTAKVNKGDATSKGANKVKPKKKKKKVAPKQAATGELELDKVAVTPKVNDKAAAEPKPESPAGVPGTVKQRRHRRRRRRGSSASETSVAAAAPGQDSTNAATHPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D626</accession>
    <name>A0A061D626_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766555.1">
        <property type="nucleotide sequence ID" value="XM_012911101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D626"/>
    <dbReference type="GeneID" id="24562910"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106780"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="344" mass="37495" checksum="2BC231C9CC8AAE23" modified="2014-09-03" version="1">MYVPPAIRVTLGCAEGGRLARFARVTDPRHGRRIEAVARECEGHTGIPTTKAARRQLHELLDLGVTDTVAFIKEIAAPLTEAMDNRECLARNAAALAHTKSPCTPNKLRSKDVRVLKYRIRSLIHLLSPQDTAMLACALAHLDSRLGIMARPLIKHYIRALEEDTAHSINPGDTVVSLALMLTSLEMFVRTHSQQLKQVADGGHSERENDAERAANDDTSGDVVTEAGNYACNVPVRESIGEPLPGEAEVPLTVHDKFHYGAIMTTMLADCLKADEVNDVELMLLLAQCMGNISVPAALPSELVVQKVDLRDLDDNQLCKFTHACASIMTLHHVNLDGVIEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D647</accession>
    <name>A0A061D647_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation transporting ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0211750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768219.1">
        <property type="nucleotide sequence ID" value="XM_012912765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D647"/>
    <dbReference type="STRING" id="5866.A0A061D647"/>
    <dbReference type="GeneID" id="24564574"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211750"/>
    <dbReference type="OMA" id="QKTKYVW"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1114"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1157"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1229"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="11">
        <location>
            <begin position="308"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1258" mass="139200" checksum="B61ADEC9A260AF59" modified="2014-09-03" version="1">MAQPDHTRRVFRYVGRHAAFAQFSIAVLGIALAAAALHFRKIWALFSKPAEEAAESVAEGEVKVIRVDYAAIAARLRAMDTSECFLLVLFVVVCLVAAAMLLSLWYIPVRLFLFYESCPFVEGSDEYREYVLRKGTHVYIIGIKPSADSTEERRAIPSVITQLLRSKLYSYYTHGHRKYVLNERSCEFEAVEHIDSVDVKVLEAWRGLSAKDKVSTRVSGIERSLVVCEDTFGDNDYQIPPCDFWKMLFDAFLSPFFLFQLLASILWIFDSYWYYSCMTIFSIITIEVQMVKKNIREYDRINSMRIPPADVLVYRDGKWTTISSAQLYPGDIFLLTHDAAAESTVVRADCLILSGEVVVDESILTGESVPQFKSALDLRLVRSQKGALTEADSEMRQSTVFAGTSIMLCRADGQSFGAVKPPKQGCVCVVLRTGFESYQGRLVNAIIRSGDRVTASNTEGWCFLAILLTFALVSCTFVVRRLPTATLKKLILTTLHIITAVIPPEFSVILSLAVSLAILQLHGKGMYCTEPFRVPYAGDLGVCAFDKTGTLTEDQMKVVGVVVGNDVSSLQTQPGQQAQSAPLPIASALVVGGCHSLSRVSGNIVGDPMEKAAFEHFGWTLSADNKSVEGLNPWFYESGKKLAPAKVTVLRRWQFVSELGRMSTIAVIGGRTTYWQKPLEGAQAGSSGGNSHQSASTELKHGEGYLRLDNSYDGDVMLLCKGAPERVRPLLREVPEYYDELYQQLAIGGMRVLTLACRKLPITPTEVPSVVREEVESSLEFVGFLALESPIRSSSVICMRQLDGHKLIMITGDNVLTACHVADAVEMGDRSNVDLSTSARKSWGDFAILVPEEGGFCWRLRNGNPVPRVAKSGDFVDHMNEIKQSMRLCVTGPAIDALVDYERRSGRKVLAEIVLNTTVFARVSPQQKKFVVRTFKRAGMKTAMCGDGTNDMAALKVAHVGISLLKSAFKKPHKELTNKLGDMIRKQPHQLQREALEKLQRDLQDGMPELKLGEASIASPFTYRKNDVLCVPLLVRSGRCALTTVVLLHKVMGVNSLITSLGMSVLSMDGVGLSEAQATVSSLMYTFMLMALSKSKPAQEHSSKRPEKSIFRPASFTSFVLQCCLHVSVILHLWGIGKSLRAPDYVPNLDAPFAPNIVNTVIYYGCLVISIAGFLSNYRGYPYMQPLWENKFLSRPLAAAALFVLVLASDLFRPLNDYLSLVEIPNHTVRLHVIAVLAIDILGAVAIERLCRRLLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D650</accession>
    <name>A0A061D650_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparaginyl-tRNA synthetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0107080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766585.1">
        <property type="nucleotide sequence ID" value="XM_012911131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D650"/>
    <dbReference type="STRING" id="5866.A0A061D650"/>
    <dbReference type="GeneID" id="24562940"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107080"/>
    <dbReference type="OMA" id="SCPAYLQ"/>
    <dbReference type="OrthoDB" id="360585at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="318"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="563" mass="63167" checksum="27CACC79FFB444CB" modified="2014-09-03" version="1">MYLTGNNSNGIEKSRYLNTAPQYAFLVSRFDGLTDRSLFGIRKSDLRHRQGKLETPSDNRCESIESDNLPDGSHFKPCRVTCANLSREMQSRSKSSTDVLIDSGGEVPKTELGEFCLNNTDKSLYKLVAWVKKLVINRNKTGSYLEVVDGTTPMHVEVVIRDTHPSYAAVSDINVGDAITIVGNLEKKCSGSDSVHPAVQLVVTSEAKGHVFTHHRNERNQEETNPVALNGNYPLMYLREHCNFRVRNPLIQAIFRIRAKATEELFRILPDMGFVHVTAPCLTSINCEGMGEIFKGPTTFLSVSGQLELEALCSGISRVWKFGPAFRADRSDTPRHLSEFWMLEAEMNDVTLSELTDAIHTIVKRTASALLTECRDDLAVISQNGEAKVINRLQNLHSSALKTLTYSDAVNLLNNHKLTGRECEYEHINWGEPLTAAHERGLLKLLDHPMIAVTQYPASIMPFYMERLTNGTVNNVDVIADGVGEIAGGSIREVQYHTLKRAMQEHHIEGSEYDQYLELRKFGNVAHGGFGIGFERMLMFLLGINNIKEVIHFPKLRKKYTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6K5</accession>
    <name>A0A061D6K5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GCF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768477.1">
        <property type="nucleotide sequence ID" value="XM_012913023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6K5"/>
    <dbReference type="STRING" id="5866.A0A061D6K5"/>
    <dbReference type="GeneID" id="24564832"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301950"/>
    <dbReference type="OMA" id="SACLEPF"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="83008" checksum="1649BF8120066DE4" modified="2014-09-03" version="1">MFAKRKLLGKNPDKGKPGAKSAPSPGNAAVNSAPGGAEAPATAKVETTDVERPKPDGTTEKRSFRRGLRDGSGAAKEKAGAVSQQGGKGGRKSGMSGLSFNEDVKSHGDVSIRKGVTNTTAAPVSHESNAPGVGSVGVNSDINTPHAGTKPSRGKRGNRRKGRRGPSTAEKTLYLDVKGEKFDSQKPYDQHADNDITGMRTTGYFRYPRYDWDSGDMSSDSFDSYDYRRRAQQANRKPTVNIYEELSKPFTAADASRLMSQRLSALRKDLYEYTDEVDKAKQVVESKNKAPERLDAALSGITANVELFDMLVEEARVLGGLCSTKLAEVQKTLQEMHNSNKDYCDGIYCMYRWLLCDLLRIGGFDCDYSCGYLDEVDDDGNDLAKGVKRDFAKREQSLHSFIAHQKSLAQLRVGAVLKEAGDASIDRYMSEDVTACFTVSPSWPEWQALYPCSSPSRFKGADVMGDVCEKYKTLSSSISVFMNFKKSHMNEFVQLEVGERLKAVYRLYAMADVLTWDFFGDSRNAALGFVGSEWFGCVKNFCPEHLPQLVLEVVYPACLKAIETWDITNALQSRSLARLFIQTIENLPPDGRGASIDKLGSQFVKVLESRVGVLCPRVSRTTFKDGYIAGCWKFLIVQIARNVMHFSDVFTGNTLSKVLFDILFLDRLLPTLDFQLACDAFAVAQFLHVVKTLSPQLRLKNKVNAVIKSSSYAIAERNWDNRAGFSVVWDQLNVTLRNEDYLGILNGIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7P1</accession>
    <name>A0A061D7P1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765921.1">
        <property type="nucleotide sequence ID" value="XM_012910467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7P1"/>
    <dbReference type="GeneID" id="24562276"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100640"/>
    <dbReference type="OMA" id="QTGDEWE"/>
    <dbReference type="OrthoDB" id="360041at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595866" evidence="2">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="450" mass="51617" checksum="E2FAE01F021A7DFF" modified="2014-09-03" version="1">MSPACGLLLIFLTLQITDARRTLRDHGLAGSFRHGTSPWNARGSLGGAPNAPITAFVGPSGGRLESFNSRLRNSSNRLQPIKAISRTGVCVPEDVGLYGRTVVAYECLYSKDGRTQTGDEWEREQIEAANAQAPKKLKKPKKEKLSKSTDETAAEPYKRFIFPPPYNTTGMLLREGEPYLVLSTWLPGVDKDDIFVAIDYDSSNGYVPKRYARENLHQLHLTETAHKYYESIEGVPRGFEQHERSYNSTYNDLFNRVVENNEDMNHFAFYSKAKDRPPMIIINAPKNTVVKQFEFNTFGRKRDPNHPNRAKKSGLTGDPIPDRIQRAYRPFSYIDLRSVQCNMSDATLQIRAKLTHVPPPPDMKKIFQLSIGHGEVCPPRMFPVEQVHGWMYNWHHFPKYDLEYDMSKLQPPEPDPEMEACMEMPDDDPMTKREALRLMREYDEWNKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7X9</accession>
    <name>A0A061D7X9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="4">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0300120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768293.1">
        <property type="nucleotide sequence ID" value="XM_012912839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7X9"/>
    <dbReference type="STRING" id="5866.A0A061D7X9"/>
    <dbReference type="GeneID" id="24564648"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300120"/>
    <dbReference type="OMA" id="PYLENYM"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="413" mass="46395" checksum="A48EA2B26D41E1B5" modified="2014-09-03" version="1">MEDAPISNVMLIGAGGLGCEIIKNLAILGVRNITIVDPDTVELHNLTRQFLYRRNNVGMYKAQVAAQRITEHSKHITANYINQAIQNVPLTTIAKSDVIISAVDNVEARRWINLATMVIWQKRGNNVNFDSQRVGNPLPILIDGGSQELYGHVRVVSGRDQPCLECSLPLFSDEAYQPSCSIPKEPKSPEDCVRYVISHMFEDFTNERAEVKLPSNTKPISTVQGMRHAEIVDRVYEEARKYANAYGIETVTMAMVRKILNRGAINVNTTNAIIAAVIAHVAVNRDATKNFYFYSGDGNSVLDGFTMQKQEDCTLCKCKVITLQTDCQQTLKQLIDQIECITHSKNINITTKKGAVYLGSSSHLRELYNIRLHQTLDELKDILDENMYVTTPAGEAWYYVHMQQCHNLCCKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z0</accession>
    <name>A0A061D7Z0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mac/perforin domain containing membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767225.1">
        <property type="nucleotide sequence ID" value="XM_012911771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z0"/>
    <dbReference type="STRING" id="5866.A0A061D7Z0"/>
    <dbReference type="GeneID" id="24563580"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201960"/>
    <dbReference type="OMA" id="YCFTYAA"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013130729" evidence="1">
        <location>
            <begin position="16"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="2">
        <location>
            <begin position="44"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="651" mass="71411" checksum="E201E3E00E2F3FE7" modified="2014-09-03" version="1">MQIIINFCLIAVVQQLRLSASSNPHSGTTETSHEKTIDSAASTESNINFKANKIVTGLEYLGSGYDAVKANTLGNLEHGEDLGHRAPIVDFYWARSDVGVTNSLEWLQPLGGWVRPIIACGEYETVTEGTNSSINEDVVQLNAKGDATLQAGGNGSIDVAYDKASKTNVNKSSKVHKNSYYCFTYAAGMPPYLNWNTTEEFQAELEELPATVKEFENCTVKLFKNKAKVCEGMSKWVEFFSLFGTHVTTEIHLGMFAVVNSIICRSGGKITRILTAPSDAVESFSKSGLDVNAAVGAIISGALVDAKAGLKSSEQDALQEFSDSCDLRFSVLGGIHVSKNVTPQSLLKWRATVPLFPMPIRIVVTPIDTFIKKKYKNAYREAFNFYVELSGALPWVVQQHNGIDFNVKTMLNSSYPLAVGSKSGKPPCIECPNHTRILFGFIMEKDDAKKTTTLYRCLSNSSSCFREQNTASQMTIWALCGNSMGLSIAQYAMNFESSAKEKAVKCKAGFTLLTGFILETLPDQKHYIKSATPCNTGSDTCRTDSQLETRIWAVCVDKRFPGMEVVLPLPAYDYLQNVTTLAKSTEISTRDVLGKELRILTGVLTIFINIPICHGESLHIDTCERYTKGCSLTKESNGSCKSLAWGIFLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D867</accession>
    <name>A0A061D867_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0307750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769057.1">
        <property type="nucleotide sequence ID" value="XM_012913603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D867"/>
    <dbReference type="STRING" id="5866.A0A061D867"/>
    <dbReference type="GeneID" id="24565412"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307750"/>
    <dbReference type="OMA" id="EWISHKV"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="242" mass="27968" checksum="3B1D9F8DF7F91BB1" modified="2014-09-03" version="1">MTNLDIPRRAGWYSRLIVLHYVSSLCVWVSVELLLLTFLLRHEEGHWPTWESLSRLSPVAFWTYIRPLFQCGLVAQCLMHVYTFLDGACCGASLYLNLEQCVRTFAVYFVAIPLLKEVVPMRSVLLPVSALTLMNILSCLDALYTVRGTCHTVLEWLSHKVVLVLYPLLAFEEIWLVRQAARVVRNVPIARDFPSPMPNAYNFAIDTYYMYSALPLVMLPCSVLYYCYQVRYRRLARRANSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8A9</accession>
    <name>A0A061D8A9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0308300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769112.1">
        <property type="nucleotide sequence ID" value="XM_012913658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8A9"/>
    <dbReference type="STRING" id="5866.A0A061D8A9"/>
    <dbReference type="GeneID" id="24565467"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308300"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="898"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="920" mass="103418" checksum="7E6283BAA60FD515" modified="2014-09-03" version="1">MAATYRIRRVEDTPWHGIAGQYARCGAEFGFIVAPGSDRCDIRHTSHWRFSHTASTTQRRGSFQRVHDDEGAPDSLHRPLCLYARPKKNKVESSNTDEPQLTAQVPDEGAGSPKAAECADDKAVVNEGTDVGVPADVTAAAKRKRGRPRKVKVEDDAAASATDGNNSTPEITDDNASAEPDITGTDPADVVMSATTSDEDVTQQPVGDHQDTVIGTNPEIHANQEIHASQEIHASQEIDTNREIGTSQDDHVDVEVSDGSAQDSEVERHDVVDTATEGNDEIAEAIPTEDDEAATVISTEDDEAAAVISTEDDEVAEVVPTEDDDDEVAEVVPTEEGEVAEVISTEDDDDEVADVISTEEDDDDEVVSVTEGVGSVAEIEVTTEDEEGTDEQGKTDASAASDAESAKSADKSGVKGPRTFLQRLEEQLASRKTRLPESFYAEEVYSTFDNTKLPEGCKTLMDFFNLPKNFDFKSMVDLSLHGTDSLETLGVYGTDKPQKLEEPVYSGKYPDSFFETIFHYEPEPRRYTTAEGTPESVEVDRMYYTLKGKRPGDIVPPERQSPVEKIREHYLMFDVHDHLKHYLTHLNQYNYRVLSSHHKRDDTLNHYLNNEYIQYIPKKFPPEPDHTEKIRAYFMDILPELMDTLVNLIKNDPNKDRTPSPPLHDMSFAPGFQLPDYMQRGYETDDERTSGFEEKDYLRFSSLQGLHDPERHLHYPYADVEPLYQRQLLSTYLDLVKTGELGEPDTYKKFKSQAASIRNELYTDRTRLPQEIYGRAGSKEARKPIERTTRLTKVYERGGRKRSVALVYLEPGNGHIIINNRDGYQYVRYSAQRIREMLEPLDVLYAYKKFNIVAVARGGGISGQTGAIRHALARYLTKVLAPKIEPYLSMRDLTKADTRQVERKKTNLRKARKEEHYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8C4</accession>
    <name>A0A061D8C4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0103070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766171.1">
        <property type="nucleotide sequence ID" value="XM_012910717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8C4"/>
    <dbReference type="STRING" id="5866.A0A061D8C4"/>
    <dbReference type="GeneID" id="24562526"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103070"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="127"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="15">
        <location>
            <begin position="371"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR93985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="468" mass="53713" checksum="8722E97ABC4BD37E" modified="2014-09-03" version="1">MIKHFFQAPNRHTPDSDDAFPYIAFDSVPVTIRDNFDELQVPLDHVSREPSENFYTSKEYVQGYARQRAELHPRILSQSRNAGYDRGMINRMADELGHSVHTVLPTHATSHLPDLLRRGLTRAIYSGQVFRRDSIDAKHYPVFHQLDGFRLFSRKDLEKLRRNAGIEGASLSDEQLIMYDLKCTLESLVKHMLRRVVSADMRPMASEARANSTGKTDAHDASPLQSTDFDNQVEANKANVAVDTKHADEYDLLRWDSDTSFPFTDPSLELYVKLENDYVEILGCGKLKNVIIRNILGSDRIAEDVGRSGCGSTDTSEIVGGWAFGIGLERLVMALSRITDIRQFWEEDDRFLRQYRDFHKHGTMPVFKPYSRNPAVIRDISFYVDGGDEIKKAFDECEFRGILEELSRDYVEDVTQLSEYVHPQTGRKSLCYRVTYRAMGENLTNAFVNEIHQRALNRIVDAFNIELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8E8</accession>
    <name>A0A061D8E8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain/ mitotic checkpoint protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766201.1">
        <property type="nucleotide sequence ID" value="XM_012910747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8E8"/>
    <dbReference type="STRING" id="5866.A0A061D8E8"/>
    <dbReference type="GeneID" id="24562556"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103330"/>
    <dbReference type="OMA" id="WDSTLHI"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="333" mass="37437" checksum="1F094D913B18B60E" modified="2014-09-03" version="1">MLVPIDDPPTDVISRVLFGRSRNHLSVASWDKTLRLYHVDDANRARVLRRCSWNSPVLDCAFLQDDRKVAFGDLDKKVNVFDVETGKVVTLGSHNAPVRCVQYHNRLNVVISGGWDKRLRAFDVRIAAKRPVAEVEIYGKVHCMDLLNNTLVVGDSMKRVYIYDISRGFSGFATPETKDGVLKFQFRSIKCFPDNRGFALGSIEGRVAWEYFSKLPESVSQQYAFKCHRKKTMPDSDVAYAVNSIDFHPRYGTFVTGGADGLVCAWDGLSRKRLWRTTTLPTSVSSVSFNNTGEKLAIAVSDIYQLEGEPAARPCVLVRGINSDECKPRNYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F8</accession>
    <name>A0A061D8F8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0103440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766216.1">
        <property type="nucleotide sequence ID" value="XM_012910762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8F8"/>
    <dbReference type="STRING" id="5866.A0A061D8F8"/>
    <dbReference type="GeneID" id="24562571"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103440"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="8">
        <location>
            <begin position="316"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="426" mass="46064" checksum="465586A53474686D" modified="2014-09-03" version="1">MKCLILAGGHGTRLRPLTLTVPKPFMPFCNRPIVEYQIEASLEAGVDHLILAIPQDQRSMLPMIDKLSEKYNVRIDCSIESESLGTAGPLKLAEKLLCDPEDDCNDFLVLNSDVISNYRFSELVAAHRRNSADATILVTETANPSDFGVIVHEPDYRIKAFVEKPTEFISNEINAGVYVLNKSLISHIPLGNVSIERYLFPKLVAMGRTFCHPLSGIWADIGKPKDYLHAQGLYISGHAHNELAHATLCGTDGSECPEEGPLVAVKTKGGLLIRRKAECDAGAEWTAGTAGTAGTAGDVTDEISAYPNIGKDVVIHPPVLIHPSSSIDRGCVLGPNVCVGPNTVIGEGCRILQSTILEGARLGAHIYVEGSIVGWDCRIHPWVRVEGLSVFGKNVAVSEGLFVRECIVLPHKVISKSIHESGSIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H6</accession>
    <name>A0A061D8H6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mechanosensitive ion channel MscS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0203770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767405.1">
        <property type="nucleotide sequence ID" value="XM_012911951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H6"/>
    <dbReference type="STRING" id="5866.A0A061D8H6"/>
    <dbReference type="GeneID" id="24563760"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203770"/>
    <dbReference type="OMA" id="WGNWQRI"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="5">
        <location>
            <begin position="696"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="887" mass="100339" checksum="A50D8DF708C3FBF9" modified="2014-09-03" version="1">MYSSSPMEQRDSRIEILSVGEDESTPTESREKPPAFAEACCDDDEDEAAEIADSCLRLNKFFHELFPDRQVATWMSIHAVIILVYALFNFNAYTVFLQSQNGVINFNINMIWCLLFIWAGNLVMYIATMIIRYLLINLLVNLPCSRNAYVFASISMLDPTIFYLLWAATQSVIWQILVSRLKDEAHMFCIETPFWYDFTHKYLIFREDAMVWITCAIHVHLILAIRSLTLAVISFTFELNLLVNSNEALKKYLKLYTNIRKFNIDWLALVISKPELVKRLKKALLLKQHDGKMLNDAQSNSDRITDFKNQNALHILHEAHETAYMQYFSTKEDLSVPSDTTDAMIDQSSTSAFANWLLIYYVVRVPPVISLIREDIVLRGRAEIETCAAMLFEQMYMTLNERASSGGETDDLQSDAEPRGELTQAKDSSEEDNIDSPEMATTAAPELGDMGAPETNDAVDQSVSKSPALGATPSDDNAAAKAVEERSPSNAKPTVVRIVEPPRGPSHGHHQMAQASEPSQQATTSMFKVCTSPSKVRLRNHRTISMMHLEQFRNSLLESEASQEFPDQSTTADYQFHVIDGYDSRFICMEQMRSFLLPKECDTIMSLLDLSRHGKINQSMLQQALLNLFSTQKKFTNTIRGQDSVFKVLSRLLSVATWVLAIVTMAFLAGITAEAIVVSGAALLSALTVALSYLYTNFVTSVIFVAFSNPYNVGDRVRLNDGEPLTVRKIRTYTTEFVTMLGKVVVYQNAVLSTMKITNESRSSKATVNYQFKVDAETTEEQLVAIESYLKNACNMRPNDFVKDSCIVFYLGFNPGHCFDISVWVTCVESWGNWQRIYLLKGELLELTLRQCKKLGVTYMLPTQPMTFPHTLSIRNTQKREPSQNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L6</accession>
    <name>A0A061D8L6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769242.1">
        <property type="nucleotide sequence ID" value="XM_012913788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L6"/>
    <dbReference type="GeneID" id="24565597"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309590"/>
    <dbReference type="OrthoDB" id="338345at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="401" mass="45025" checksum="F2BF0FBDB47B487A" modified="2014-09-03" version="1">MSGLPAAFRRLQLGGGKDDELPRKYMTRVDVEDHIVPLWEHVSQEEAESVDRASADVALEYRYSLESFIQRSSITSEVTVSSYADDFSRLSESEVEENDIRGVYLGDLPNIRVKPGVLDPEAHPVCVEGVTIHGGTVECVDMSPYREQFAVLDYEWFLGLDYNCADRYDPDCVGRGPTFMLPFDAVGKYVFCRAHRRVEHQAVDEFSKPKVGVYDPHVSAATKAGYVPHPQFYILESLAQGSYRTEAQLHFDDDLSRGVVSSPGENGGRIELTVDFNGVTLKDRDSQQTESCSVTNMRKVYNSRVFGGDGGVASLEFADFEVEEAGKSTNGLLLSIHKCSPLVCYVFLKFTDDWKCLFTLFILSSFRCQKALGCDTEYWNSKLVDADVFSVRELFRESVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L7</accession>
    <name>A0A061D8L7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Exonuclease 1</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0204120</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767440.1">
        <property type="nucleotide sequence ID" value="XM_012911986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L7"/>
    <dbReference type="STRING" id="5866.A0A061D8L7"/>
    <dbReference type="GeneID" id="24563795"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204120"/>
    <dbReference type="OMA" id="HRFILQY"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09901">
        <property type="entry name" value="H3TH_FEN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0228">DNA excision</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="134"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR95254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="490" mass="54352" checksum="801609D439F3457D" modified="2014-09-03" version="1">MGITNLLKCVGIKNYAGSVVAVDAMCWIHRGMISSAVANVTGEPCDKYLKFIISILSVLLSHNITPIMVFDGYEMPTKERENQSRRVRRDKAREEALAMIKKNRGTINTEIMRRCMQAISITPEIIARVMAICREMNVRVLVAPYEADAQVAYLCRAGIAHCAISEDSDLLAYGCPRVWYKLERDGKADEVNLGFSSDPDVKCTKGMLKGLSHRMFVAMCVLSGSDYDDGCHINGMGIKLAHRFILQYGNIPAILSELEENASWAKKLPAHVTRQQLEAHYMNVSQIFLHNVVYDLRSDKLTHVTPISQGETNMDIIVDITHRLREKEVNFRAVSAGHVNPRNGEPLQYTVTDKDRELTDGMRFADIEFLSSIPSPDASEATTDALLQECDSASPQVHRVVAVTDVPQESAASTVAVTMATMLVPSGGSDVVERITGHLHTNESNASVSTCDEYEDVTCSQKCKLRALIDSSEKVVSVRPKRRMSARLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Q6</accession>
    <name>A0A061D8Q6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769282.1">
        <property type="nucleotide sequence ID" value="XM_012913828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Q6"/>
    <dbReference type="GeneID" id="24565637"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309990"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="99" mass="10675" checksum="4CB1B59AC8D8FA23" modified="2014-09-03" version="1">MELVRCLVIGANITLPTTLNVSCQLGDLWDVDYENCANKLLSSAAERDAERYLAYEEIADVAAHREAEDAQVEQDDGDDDGNDDGGDGWGAGRKGVEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S6</accession>
    <name>A0A061D8S6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769302.1">
        <property type="nucleotide sequence ID" value="XM_012913848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8S6"/>
    <dbReference type="STRING" id="5866.A0A061D8S6"/>
    <dbReference type="GeneID" id="24565657"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310190"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="287" mass="31077" checksum="E62994ABBBB75111" modified="2014-09-03" version="1">MALSPNVFWAQTKDAVYMTVEVEHNKDTHIDIKDEALAIKAKKDGKDYECVINFYKPIKSSEVMKADERFLRFKLPKADEEKWPTLNNDGKKHWLKIDWDRWVDSDAEDDDAARDNFDMGNFGNFGDFAGMNPGAFDDDDDDYMGDDSDFDKKGDCCSIGDCACDKCECGSVCKCSAKCKCEACPCEVDCDCDAECMNASGCCSKGDCACDKCECGSICKCGTSCSCGDCPCDAECDCGAKCLTTGGCCGKAESDRKCCENCTCGSDCACTPENMCAANCKCGVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Y0</accession>
    <name>A0A061D8Y0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">tRNA (adenine(58)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0105040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 8"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766381.1">
        <property type="nucleotide sequence ID" value="XM_012910927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Y0"/>
    <dbReference type="STRING" id="5866.A0A061D8Y0"/>
    <dbReference type="GeneID" id="24562736"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105040"/>
    <dbReference type="OMA" id="ASCIGKF"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="10">
        <location>
            <begin position="75"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="281" mass="31397" checksum="CEB08C39E15CD704" modified="2014-09-03" version="1">MEIAPGDPAILYTGPEGLLLCQIPEYQGVIGNKQQAANSGDKRLLHRKGDIFDLCKVIGRQYGQKFFWDSVADRWSVLLQPTGELITRTVTHRTQILYRADISLAVMLLDLCPGKRVVECGSLSYTLATTVAPTGHVFTFDFHNQRRQYAEEFFSNCKLTEYISAYDRDAYAPGAFLVEGAVCESSIDSLFFDLPSPWDALDNAKVVLKNFGKLVTFSPTVEQSQRISKVMSESGFIEIKTFEVLCKPWGIGFDDLGNFSCYQLAQVNHTGYLTVSTLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z6</accession>
    <name>A0A061D8Z6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0310790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769362.1">
        <property type="nucleotide sequence ID" value="XM_012913908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Z6"/>
    <dbReference type="STRING" id="5866.A0A061D8Z6"/>
    <dbReference type="GeneID" id="24565717"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310790"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="23550" checksum="BCF62006EFC9563A" modified="2014-09-03" version="1">MESSDQGALIAQGAEARVTRILYLGRNAVLKTRLSKQYRHPELDDALNSKRIVAECRAVARLRRHGIYVPLVYLVDVKNRQIVYEFIKGQTVLDALKESHQDICEDVLKRVGVAVAKMHDVNIVHGDLTTRNMLRTESGEICLIDFGLSYVSTLAEDKGVDLYVLERCCDANEFELFLNAYKQQSRSAAATIAKLAEVRLRGRKRDQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D902</accession>
    <name>A0A061D902_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767550.1">
        <property type="nucleotide sequence ID" value="XM_012912096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D902"/>
    <dbReference type="GeneID" id="24563905"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205220"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056351">
        <property type="entry name" value="Microp_dom_apicomplexa_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23522">
        <property type="entry name" value="Microp_apicomplexa_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595925" description="Microprotein domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Microprotein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="79" mass="8872" checksum="AE04582C68D89F10" modified="2014-09-03" version="1">MDLHAVCVAHCFLFLLSLWTPASIALRNIANVSYYYDISLFDTIEILPSDEEDGDGLLNFSTMNDVYEFSKNEGGAFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D954</accession>
    <name>A0A061D954_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768698.1">
        <property type="nucleotide sequence ID" value="XM_012913244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565053"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304160"/>
    <dbReference type="OrthoDB" id="367204at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2208"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1380"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1410"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2270" mass="255670" checksum="AC1A5AD693004E94" modified="2014-09-03" version="1">MAPQFKKLTDCPENLREAIDWLIQIKNGKTDGIKNLSEALQKFITDAIWVTQDGINSRKEKVEKIYDIAAKRSMLNKLGEQEKSFDKLQESLTPLLENLQLTSKYPEKNFLTQLCAGLETFIGYNSGNYTGEGIVYGDCDRLRDAVTMFLNGVFDSIKSDDAVGKYVVNVDEIIKFLNKKIGNGHAGFISAISSVESTLSMWNNMFTQRTNEVKGQLGELKDKHINKYSQNIEAVKDNGCTAINTSLMQSIVKLKAFLTGIRKNDEGFNGLDTGLKDKLNVPLEKIDEGIEMLQHALHDEDLSRAVKVIESTFNKLPAELYKFISDNVTITIGEYEKAIKKIKQKVKNDIVALRDDFINKRLALAQKDLQHAVERANSNASNLGGLRNGVVKSAIEIIEKMLNSADTVEDQKALLDLKAVTVGPQIEAIRQELSEGATNMTNALKTLNTTIEEPTETFKNKHQDELISLVEQARNDLTKALHCANEHAKNLGGLKNKTVEVALNQIEERLNTVDTHVNSLKTLQELAQDPVGVHIGHITDAKNPGGSAVEIHVTSLQGNIDGPDDAFNKHKSKLSGLARKAQTNLDNIIGKAQDCIMAHGGLNNVSFKNAIQKIQEKLDTVETDRLDSMDALKRLEKEPVGNQTQAIKLLLNKDAEQITKNLKNLEDKFANTDKVFAGYKRSLESLAEQAEKDLVEALVQADVYVLCTDFGLKKKIMDAFGHVLKTESKNRTGEAKNLAKQVVAKLNALNKDFNSSYRGDINNTFTKLPSYISTIESRIEAKLRSNGDNDTDIIAWIYDVTSSLLDYTLKEANADVIKSDQAYRKSVKAALQLIKVHIQTLKTNAQNDQLEGFLGGYERHFSTIQSAVTDHSVYDDDKKAREKYFSNLMQLFNDTISTLSVAYKNAYKSAAKSYLSGAISKINAEVKAAEVQYQMSINGLTSRIASEIVHLMEKARQDKLGEVISNIDAPLKQITEAIKQKSVFQSDIADRETYFDNLRDLITNNVHTLDTAYQNAYKSAAKAYLNGAISAIKGAVNKVQHTYVTKVKLDVDLSGINHEVFTKQATRAPLTGTLTVPFTEFLQQVEKNSIFIADFTERKECFNQLQKLITGTLATLSAAYKKAYQSSAKTYLSNAIYAIRQKVNTAELQYTAAVSREIEKLKGKITALQDDIFKDDKSKKKEPKEMLKRKQLGESFTEIFKELQKTVEENSAFRTDLNARRDRFTQLQTLIKNTTDTIAKSSETFDICVTLSDHYLNESFKDADHRFNMLGSSVKVRVKEAFDKITAEVRTMYAKDRIANIRALQSLVERQQINVGKIIEEDRLTGIKGLLQLLKTWFNMKNAELTNAETMGSVAAKFKGLYDILHKYVKFLYDGMEVEGDSDTDDNPVSRPAPPPISGGGYRARPAMLSVSSKDPNAPQPAGRAGYSGEMRRTSTGQQFLSAQPIKDPISDYFDRLDHHTRGLFGTLSSGYFNKSFASKLEEFVRFLEPMSPFKFGRHCDPLLYILKSGLQSFLRELGRAYISTYCGAAYVFKWEINGDKCAKVCLTMLEILFHDLDGLRNKVKTKGEWNDKHIRLYNIANSEKTDNHLGAWFQHRGFTVSVDKDTQNGELSRIKTGADIITRLVGDGTRVNDKIYAGPDKTDGALQDLHYHLEKYYEVCHRRDIPDARAPTTIYEMLHWLGGLWYNPVFVPLQESLKKLLEDVERENKVETDKLKVALPYRRSVSMTRTLTRKELIYVFNNSTIRANKMLIAILGHGQEDGRYACDFLTNPDDLLYPSNPDKCLDLLVEISLRVNHQIRFLFKQCHNGPECGGWRDCLYGKGVGGSRWQCNELQCSNQECDQKCRQYYSCGVKSPLQLFLEDGLPGFLPHPFEKPDCKITCSLPNHNGIPCKTPMGFRDLSIRASHQQKGERIKKVLDWFCGTENESLNLLCSYFLLLLRRPPQTLCDMFAFYYNFLDHYDDDRSTQKEHRRLAFNDAVTRANLGCPFDALNPSTILCTSKHNPTDGKPTHEKGDLFSLLSCNPEDSPTMPCGRYLQSIGDDIRLLYYGEHAGLYLSWIIYQAETFYNLLKDLSDRCCKSCTSPGSICYGTRCAKDCHVASVYKANKSTDNKEDLKALDGKKHNDECNSIVNCSNTHSILYTYGFTFGSPFDLSGGNNKMEKKRTCQDFCRALDNVLNKEKHVEAPLAKLVFDIIPEYLWVIREPFFWTTVALWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAGRVSKLGKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D980</accession>
    <name>A0A061D980_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0311490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769432.1">
        <property type="nucleotide sequence ID" value="XM_012913978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D980"/>
    <dbReference type="GeneID" id="24565787"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311490"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600171" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="823"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="953" mass="106971" checksum="2DD5BE5DF80470BA" modified="2014-09-03" version="1">MVKLRMVSLLYCAIWMHWIGCLDALLCDLSDPEEPLGSHALVMCHMDTDTMEDAIATCPRRINDNTEYVWHPQPTTDGHPHIKTYVNDNGSLRSRDLSDIVITEKQASFISVESNRSQTELYFNFPSHELFILTERRLIFICGPRDLVLSDTMQRHIYGLKDTYHMDLLPWNSSAPLVEELKEIRKGLGVFFVNIGRSHLPLQGCGSRASPLFSPDNVVTEDSFTGTRSCVADPMSSLPIGFVCEGRIQPENCMKSLLDKNGYTVTAPSPHKYWHFDDHRPWVVAQYFDQLALPPFTGECRCVDSETGQVKARIEIRQKTEYTCDITRMIFRNRIRPIPGPWCSVVLHPGSTLTIKVPIQKVYRQSFDGSPTVSFSQMMSLYDFETEFLPNDLMTLRQLHAIYDLASYDEIFYQESLVGDALELDVSQISRGEVKLKYNMGRPLALKGGSNSFLYHLTVRSRNVNIQESISATINVAFAFTHHYHAVGCDRGPQNLFAPSISKLFCSAKRWGNGIGETYECTSYSTLVISWAGIQCKPDEELLPANCDSTVYDFHSNGVVPLPKSVQHATVVRILGFQTLGFTDKTPPASIGCICVDQSGYEKSRLILETNKYESRRYTVNDGEVVNISQPHRLLYWHAIGLTGGLPTSRDYLVLNNVSHKVITLRGGKALFIRCSVAPGAQQGVNGANIRPMWLPSSYNNHHYTTKQTPDGPELVLAAHGDSVATTPGGFEVFAIITTPTNYELGIRSQRQAVVISRDPLHTHYVPMTFVCVKTPQQSDFSVVANDALTSDDDGQRNARRIESSQRYKWHVVDIHVETTDPYMQGCGVTYESAGLFKPETPKIYDADGREIGCKIDIQAAKEAAFYCPVPYVLDPPNCFHQMLVNGSVQNINDFSHSLVASHSNHFVLLYSFSKLSGHGEKLRQSPPLECRCVTVKGIVLSTIQIENYYCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A7</accession>
    <name>A0A061D9A7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0311740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769457.1">
        <property type="nucleotide sequence ID" value="XM_012914003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A7"/>
    <dbReference type="STRING" id="5866.A0A061D9A7"/>
    <dbReference type="GeneID" id="24565812"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311740"/>
    <dbReference type="OMA" id="YILLPCI"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="283" mass="32389" checksum="11EFEE8E6971CDD2" modified="2014-09-03" version="1">MAYKKQNTASAIGAKISQLLRLDRGENWIYCGFFVALIVLYKLFSDGDFSFLLTLSSMISCLSFIVVTYCITSAKSCKGISLETMKCYFVLLCSRLMSIVPFQGYLPSDSSGDFLYQFSEFVACCFAGYIVYLCAYKYHDTYEKETDTMPSYYVMLPSFLLALFMHPNLNRNKFGDTCWAFALYVETFCVLPQLVMFRASDRAKKSTVHFTAAQSAAKFLGFIFWLSTFRELNARGNMLTHYVGHWVIFTQCIQMLIIADFVLHYMQCITRGISVELVMTEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q2</accession>
    <name>A0A061D9Q2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0107580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766646.1">
        <property type="nucleotide sequence ID" value="XM_012911192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q2"/>
    <dbReference type="STRING" id="5866.A0A061D9Q2"/>
    <dbReference type="GeneID" id="24563001"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107580"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000501">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="6">
        <location>
            <begin position="382"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="777" mass="87165" checksum="B5A9A0DB3AB7F450" modified="2014-09-03" version="1">MLGLQEGTVYTSNAAHGVSEEVLNMPASLPSLDSVYQYFSLFLNTYSADSLQQGKLKRMLLENVKNNNYLLEVKLDDLFQFQNIAERNPNREDDSIANRLKNLQMNRADGGDVNMEADRALPPTYAGELVRVLTERPLIYLSTIERACYDVCKLHQKLDDEDEDFHFIQINLLNTFCKPTPIRALLAAKQERFVVVPGIIVQAYRPQHKMKTMTIQCRYCDHKMKLDVPLWISKPQVPRTCRYAATIKATGGEAAQMENQLGCFNAQNPYVVLPNECHFVDVQTLKLQELSEDVPTGDMPRHLQLNVTRYLCDKMIPGDRVMVHGVLTNYSVSTRGSEPTAIGSSYLHVLGIEKLTQGKGESIAFDLEETNDLVLLATQPDIHEKIFKSIAPALYGLDNVKKAVACALFGGSRKEVGSDNRVRGDINILMLGDPSVAKSQILKFVDHVAPISVYTSGKGSSAAGLTAAVVRDKMGVFSLEGGAMVLADGGVVCIDEFDKMREDDAVAIHEAMEQQTISISKAGITTMLNTRCAVIAAANPTFGSYSDDTDTTEQHEFKTTILSRFDLIFMLRDKENIRRDTTLCKHILSLHAKQAHAASCPIPMQKLRRLIQYAKQAVSPMLSSDAKDALRNFYVQKRREYHEDKRSATKKIPITLRQLESLVRIAESFARMELSPISTEKHIHMAIELFMVATGETMKQTLSVESMSQHEQLMVKQVEDYILHRLPKGHRLSRRYLIRDVESKGFAIQHVSKALAILIKRGTIQERGDLSLRRVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q4</accession>
    <name>A0A061D9Q4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase, GNAT family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0306110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768893.1">
        <property type="nucleotide sequence ID" value="XM_012913439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q4"/>
    <dbReference type="STRING" id="5866.A0A061D9Q4"/>
    <dbReference type="GeneID" id="24565248"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306110"/>
    <dbReference type="OMA" id="DAHDMRK"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="151" mass="17788" checksum="FB2F6883099EFD32" modified="2014-09-03" version="1">MRRMTFADIYAIRSIEKDRFTELYGFAEYLMFLVYYPNLCLVIDVDGELAAFIIGKTEIENGDTYGHVSSLVVRPAFRRQKFATRLMQEFERVCREELRCAFVNFFVNPDNKAALALYEKLGYRVHCRLPKYYNTENDAYDMRKPINAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U1</accession>
    <name>A0A061D9U1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar sorting protein 28, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0108030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766691.1">
        <property type="nucleotide sequence ID" value="XM_012911237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9U1"/>
    <dbReference type="STRING" id="5866.A0A061D9U1"/>
    <dbReference type="GeneID" id="24563046"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108030"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="6">
        <location>
            <begin position="110"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="24324" checksum="0E9480D9B77B0078" modified="2014-09-03" version="1">MASTIDVDHAANIYSLLQALEHLEQAFVSGDASNEDYTQECTELLSLCHILEEATPNVFAEFAAKHNLNCPLALNRLKKGSPGICSTSKPKAQARSEVGRYFITLTHVSLQTYIIFELSEHFITLLDALKLGSTHVEELFPILHELITCLDYVPTLDDKSSNSVNVVPHLDKLRVWCSRLENMPAHHALDANEIRQLTMEAEAAYSALKAFLRMKTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X8</accession>
    <name>A0A061D9X8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0208730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767905.1">
        <property type="nucleotide sequence ID" value="XM_012912451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X8"/>
    <dbReference type="GeneID" id="24564260"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208730"/>
    <dbReference type="OrthoDB" id="10657108at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600184" evidence="2">
        <location>
            <begin position="25"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="294" mass="31632" checksum="9521F90CA24AC18B" modified="2014-09-03" version="1">MKIHTLSLIALTALWHTFITYAHCDDLGSAYASDAIVDAALESAIADAAAGSANADAAVPKAPANDPAPGKEPATGASVGNGIVNGMLGAIAHVDGPGSVDANNAAIMGEAVGGWMARALINLGEKISDAISISIRRKKLNAKVEERKMKEKERKAKEKAKQEKEKAKEEAKLAKDEAEEETKEKAKEEQEKAKEKPKDETKTEDDSAEVEKSKPKKEVKDPAKDLKKVRKERVKPKKPVKKPSQKVTKPRKEVKKPTEEPKPSAEVTKPGKEVKTPSEESKPSAEIVSLDLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Z0</accession>
    <name>A0A061D9Z0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769717.1">
        <property type="nucleotide sequence ID" value="XM_012914263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Z0"/>
    <dbReference type="GeneID" id="24566072"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400230"/>
    <dbReference type="OMA" id="RYITVEL"/>
    <dbReference type="OrthoDB" id="361009at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056348">
        <property type="entry name" value="Microp_apicomplexa_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23513">
        <property type="entry name" value="Microp_apicomplexa_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="88" mass="9635" checksum="48C5715875CD2774" modified="2014-09-03" version="1">MGSISANSLLVKCGVAAAVYYLPQDLGVLSILAFNKRSCSRRITGSVTCGPPETQVDRVIFNYMRDRGFDPANYLVHKGNLNTTVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA04</accession>
    <name>A0A061DA04_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769732.1">
        <property type="nucleotide sequence ID" value="XM_012914278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA04"/>
    <dbReference type="STRING" id="5866.A0A061DA04"/>
    <dbReference type="GeneID" id="24566087"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400380"/>
    <dbReference type="OMA" id="YTNEMAV"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="8041" checksum="5D9E0506E52A0860" modified="2014-09-03" version="1">MWRSAKSSYSRYCLEMAEILCKCLKDPYREKALARYKLNVKQTDYTNGVAQSPQLRVNFDDAFGSKGPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAS5</accession>
    <name>A0A061DAS5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769844.1">
        <property type="nucleotide sequence ID" value="XM_012914390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAS5"/>
    <dbReference type="GeneID" id="24566199"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401500"/>
    <dbReference type="OrthoDB" id="2192661at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="10901" checksum="4CBB72837F7F3A99" modified="2014-09-03" version="1">MQAYDSIDHEYLARVIDTLYLPEWLSNFIKQTTKRWNIEIRWNKNTIMHKKVERGILQGYSLSPLLLMLWLAPLISYIECLNCPLHHRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAY4</accession>
    <name>A0A061DAY4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767066.1">
        <property type="nucleotide sequence ID" value="XM_012911612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAY4"/>
    <dbReference type="GeneID" id="24563421"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200370"/>
    <dbReference type="OMA" id="LDWRNAG"/>
    <dbReference type="OrthoDB" id="360650at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="213" mass="24206" checksum="57AFF587D2DCC6BE" modified="2014-09-03" version="1">MPVRGCLVIRRSIATRPTKEQLAPLPAAPLGRKPTGYRGNHQHKKDLNDPVYPTTKVPAALVPRFPLDWRNAGRFLITAALARLEDRRILRHPQSLRFQQEGPCGARCSLHCSKSPYRCLCAWRVRGSLQHAARVDNILVSFKGPIHNPKLFTVPRPVAQKSTHQARRLLIDENGVYRVEKKSYRYPVFSSRDSQPASAYHGQVPDYEPTFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB17</accession>
    <name>A0A061DB17_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L6e, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767106.1">
        <property type="nucleotide sequence ID" value="XM_012911652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB17"/>
    <dbReference type="STRING" id="5866.A0A061DB17"/>
    <dbReference type="GeneID" id="24563461"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200770"/>
    <dbReference type="OMA" id="YWAREKT"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="211" mass="23885" checksum="90D82438C691E82B" modified="2014-09-03" version="1">MTHQPKTQRPQIRLNRRKRVLTADGEMKTVGREFASLPKIRPTLKPGAILILLSGSYKGKRVILLKVFKESGLLLVTGPFLFNGVPLRRVNPRYVIATSTNIFEMEEVGGSRCQAAVEEAVASLTDESFGKTKETRMAEFKERKKRNKGAMFVDNADAEKVAEETKQKIKDKQDKVDGVLAPFLKNSPILCQYLKTRFTLRSGMYPHKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB52</accession>
    <name>A0A061DB52_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767146.1">
        <property type="nucleotide sequence ID" value="XM_012911692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB52"/>
    <dbReference type="GeneID" id="24563501"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201170"/>
    <dbReference type="OrthoDB" id="365026at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="418" mass="47290" checksum="F037543000B11AF8" modified="2014-09-03" version="1">MSTREAEPSTADLPPISTVEVCRMKSFILINVAACVTLLATLAVVFIPFPGLRVTRQIETIDINLNEHTLPALIYVEAKEEDDQRMNFYINTRYPYHSIGNVTLGEAVLPVSKHCRNRFVASYYTDKPISIPSYVNVYDLYSGAIAVTKFFKSNAPLVYVQYDSSAYVIPHELSDPLNLEADIHDLLYNDVQYAIKTRFEDADGKIVRDVKFTANVKEVTLKIGQISSKFTNDVATFAVRTVDMPKYEVIRIAVHPLTKTAPHKHVYYVHGSNWKLAYEGNQGLQKLSNDHNIKERLTEGMFDVHRVRIEDGQQIPMEWTTPLHSKLHYHEASADGWKYTFFFADKSHILGDNILGGVIHKDASTPAAVATDRIIIVYDQAKESDQPRGFICTKRELEYVYSPISGPGKSRPEMPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB62</accession>
    <name>A0A061DB62_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit I, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0201270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767156.1">
        <property type="nucleotide sequence ID" value="XM_012911702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB62"/>
    <dbReference type="STRING" id="5866.A0A061DB62"/>
    <dbReference type="GeneID" id="24563511"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201270"/>
    <dbReference type="OMA" id="DENDHMF"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="166" mass="18972" checksum="BE917D62E8595F21" modified="2014-09-03" version="1">MADAYGDDFGDNFGIDEFAEEEEEYDEFDEYDQQRVADVDIITDANEYRQHVRGIRELHIIIQVENAHRITSPYMTKYEKARIIGTRALQISLNAPITIPVDASTDAVDENVAMGFGEATDSSAMAIDPLIIAEKELYQKSVPFIIRRYLPNGSYEDWKIEELIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB97</accession>
    <name>A0A061DB97_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl peptidase 1</fullName>
            <ecNumber evidence="5">3.4.14.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cathepsin C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cathepsin J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Dipeptidyl peptidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Dipeptidyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0300890</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.</text>
            <dbReference type="EC" id="3.4.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.1" evidence="5"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768370.1">
        <property type="nucleotide sequence ID" value="XM_012912916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB97"/>
    <dbReference type="STRING" id="5866.A0A061DB97"/>
    <dbReference type="GeneID" id="24564725"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300890"/>
    <dbReference type="OMA" id="NAVQKSW"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="15">
        <location>
            <begin position="283"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR96184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="550" mass="62672" checksum="7DA73C4CB5C02134" modified="2014-09-03" version="1">MPLINQCSDVLGIWRILETETFHDEPQTCGGSLPNRNLDNLKLGDYRRYLQARYGGLRETVVELVDERHYRRSELPPRNQWRYLGVRDPASGHGFIGQWTLVYDEGLDIDIGPSRYFGFFKYVKIDNNDCPMVLEGSQEDSHGNVQCYRTTASEIGIGWATRKVFKNGKPAFTYGCFYAEKVKDDKRHSYVLDESSNAVLRNEKHSINKWVKRDYAEFRDLSPFRFLQLHKGTYFKSIHHSHLSEYRTSDTHFANRFMQKGAHGKYACKAVADAADYYGEMELPRHWSWGDSFSGETDIIQPFSQGQCGSCYAMASIYVLARRFDILLRKLYPETNWEHTARPSVRDIVECSPFNQGCFGGFPFLVGKHLTELGVLSESDSPYTMKLEGGTSSCHVKQDSPDDRWFAASYGYIGGCYECTSELEIMKEVYHHGPVAVAIDAPQSLFNYYNGVYDDEPANHGSNCDLPLSSLNGWEYTNHAIIIVGWGEEDVEGVLTKFWVCRNTWGNDWGIGGFFKMKRGVNLCGVESQAVYIDPDLTRGIAARLVKSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ2</accession>
    <name>A0A061DBJ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770267.1">
        <property type="nucleotide sequence ID" value="XM_012914813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBJ2"/>
    <dbReference type="GeneID" id="24566622"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405660"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="84" mass="9569" checksum="77D09DC92D86D97F" modified="2014-09-03" version="1">MIQRVIKYGVCNCSFDPLAENQIGIKIDYSPLTISSKQLADNIRWTTRELAKICDPITASCRCLPDMQRTSTNIKLREPLRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBL0</accession>
    <name>A0A061DBL0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769503.1">
        <property type="nucleotide sequence ID" value="XM_012914049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBL0"/>
    <dbReference type="GeneID" id="24565858"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312200"/>
    <dbReference type="OMA" id="SASQRQW"/>
    <dbReference type="OrthoDB" id="366363at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="802" mass="86192" checksum="76025471F99756A5" modified="2014-09-03" version="1">MKNNAGYAANGFQRSAPPQRRGPYSSSELLAESARQQDFNPISSSREMRKIMYYEHMFSKLDSQDKSKKSTSSSAQSSAGSSLEHRSRDEGEVSTSSKGASKNPKQGSARKSSAPPAAADHGYGMYNTQKTERGEKASKAEDRGSGSHQIPIEQPVKQQLMIAKRDAISIKIKTQSYKAPSTQGSQSAESVPKHETDRKPSAGGESGVGVARNLLNGVEDGASQSSSPGIHSMTDIAGTKISRLLGIDQITNSSTGLSASQRQWLVPTFDLRQSASKDGERKSQSTGFDSETRMVSSLDSSTDGESSKKGSGEASALHGSPGSARESSEIKIPRVSYQNDTYTTRVQLNDESRPRRVSRFSAPLVPATSHSADDTRIPRLKSEFTKDILPSLSAELKRDSLEAAVQGGIDFPPAPVYRHSGYRLPQAFQIKAVIPPDPASERETAQAYPASQPSDSAADTSVTAEPAEEAPQAENAAASSESHEPPASKEEPAEVKQEPASQDVQQGYELEGDQMDIIVNEEDMEIDAVMKDDVMDYDPVVKEDEDEEYIPDVSLPAVEATPSKKSTRRKVKKRKAPTPTVTPAASTPLSDAAPPSESATPDSTVAEEVYPEPPPVSRVTRTRASARNAGRRRKGGAIAQDQDPDVQPAVKTPRNASRSSGRSGSSGSRRNASESAGSKSQHHGGGHHAGGSAADRSQKPAYAASRIVSVEEAEKIMELYRQHSADLERLKKLLLAGDLAGFGREVAEQAESSQPKRTCILHPRLIVARPVDPAPAPPREQPPQNPLELSLKYRLLSKLMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR6</accession>
    <name>A0A061DBR6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0404980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770199.1">
        <property type="nucleotide sequence ID" value="XM_012914745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR6"/>
    <dbReference type="STRING" id="5866.A0A061DBR6"/>
    <dbReference type="GeneID" id="24566554"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404980"/>
    <dbReference type="OMA" id="MFLEFFA"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="7">
        <location>
            <begin position="549"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="747"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1165" mass="129221" checksum="A5A29195B3CDFFDD" modified="2014-09-03" version="1">MVRERLNAIDVAAVVGNLQKDILHYNLVNIYDVTSRVYVLKFSKNEDKKFVLFEIGHRIHTTQFLRNTDHLPSNFNVKLRKHLRTRKLRGIAQIAQDRVVDFTFSSDEYAYHLIVQFFLPGNVYLTDYQYKVLAVLRPQNAGEAFFKVGQTYDIPEATVPWGVPVSRDVINEALRMLAAGSGELDSIDGGNVDKGNHAASKGAKGNPKGKSQAGTKESKAESEEISNEVKDQGSLHALLKAIFPSVHVALMDHVLKTATGDAHMGSRNVTEVEPEKLHECVEAIRQAVLSVAHASTVVPGYLYKGAQEYHDFSPFDFGNAADMYDDFNHALDAYFTKFEIKKIEKEAQPKKPIKLKKIKDDQDRRELKRQKGIEKITSDIELVESNRVVFDQVLSLIRSLVASGASWREIVDQLSLQRERGHLLARHIRSVNIPERRVDVCLPSDDPHFYGSGPSQHGKLGKKSVKSTLETTDLDDRSSATLDYGLTCFQNLETLYANKKQLAEKLERTRIGREFALKRVDDQKEKEKQKKSGKSVSLVKVRKRMWFEKFHWFVTSDGFLVLGGRDSTQNELLVKRYLTKGDLYFHADVHGGSSCILKNPNGTAESFPNSIEEAACFAICLSSAWTQKMVVPAWWVHHDQVSRSAPTGEYLPHGSFMIRGKKNYVQPQRLEMAIGVMFHIDAPQLQDVDIEQQSDSDGVDDEFSDDSEASDSPVPQEGLGRIKRQGTSGLPLLGNRGKAGDSVSLIEDGDNDADSVDPDGDDQVYDDRGVASEEDASGADDDSNAEDDAESDDSDVTDDLQESGASDSSSDYTGESDLEDDSNLSLGEVVDNDYPTDKASVEGNEALINGHMNSSDTTSGTEVVEADPVNSSVGAAVDNKTPSKPRRSVRFDMSNIVPSTNKVSDSPHAHRLLRKGTGYPCQGFNPDELMDKLSQLGLVDADQSYELPPTVRFTEPEKVEHTPEALQCLRRRMPTGMFGKSKKQQGPSKLAGIKAARARKKYGEDDEETQELRRKLTGSKVLKHVEQQAAAATASDDRSDENKSRTVYQRKEIKPLDKKELSSHMDQLRMLSKEPGPADVIISAIPMCAPYNALKSHPYHLKLVPGNLKKGAIASQALHHFLKVDETKAPYVKLITTDQFALTLIENCKIPGGAPGPKRPSNTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBS8</accession>
    <name>A0A061DBS8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768510.1">
        <property type="nucleotide sequence ID" value="XM_012913056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBS8"/>
    <dbReference type="STRING" id="5866.A0A061DBS8"/>
    <dbReference type="GeneID" id="24564865"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302280"/>
    <dbReference type="OMA" id="HISVNLR"/>
    <dbReference type="OrthoDB" id="445594at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="582" mass="64651" checksum="7B034B4F23461C2E" modified="2014-09-03" version="1">MAAKKPISVNLRDLQRVLNEGKPEMPRFSGGATGEDDDEQQGSSFGVNRHKSGPVRWANEDDDDDFDERAARDDRPEPDFSTVRSTENQFSRSDSQTYAGGRGSSPDGERKPEDDVWRSGARQTTPEPVEEDDVWRRPSSGRTADGQSGDSKRDGGMANDEDDMFNRSAMQRETRGKKLYVPPSKKYESTSFNFGDGGSGGKSRFSCLDTGYERSYTTSNVESNKAWEAFSMQRRDSETRESGGYNGRDAFKDLNKENSRSSFFGEQQKSGAYVPAYRRAQTQKAVWTPKNSSVQDIFIKAAGLTETKAAEDKKKPTKPEPQKEAREQQQPQPDAQVQQMREAVLRHNRMYEANHETIKRVVDAAKTLLSGGAMDIQQVVPEDEEELVPAVVACLVAAKACETSSDLKDVHDKFRAVAGLVIELCERREENIEGKLLTEVTKFICAWKLPAIGESLYLLEAVFDALLHCKVVTPKVALQWLENIPDDVPDRVGVIIQAAVCKHGGKGVCNSILLHGSPHDKRALIYLQLLPWKKWLLGEALEAGAGASAHESDGDDEEEEEEDIDIEALVPKPVRISKTVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW5</accession>
    <name>A0A061DBW5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0204030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767431.1">
        <property type="nucleotide sequence ID" value="XM_012911977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBW5"/>
    <dbReference type="STRING" id="5866.A0A061DBW5"/>
    <dbReference type="GeneID" id="24563786"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204030"/>
    <dbReference type="OMA" id="MSAFQTG"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF79">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="27637" checksum="356C0586327FD791" modified="2014-09-03" version="1">MPAQYSTVEYWNKRYEEIDGTYDWYMDWHALKAHLPVEVNADSRILHVGCGTSKLAQDLHEAGIHDVKNVDISASCINAMREMFPHLAYAVVDAAQIGSYYPAESFDLVIDKGCLDTMLCNKNFDETVPAMLKGIHTVLRPVMYCRNNGTLVVVSVGCPDNRMMYFEPSGLWKIRVVKVPKRHMEYLEEASPTAALPSFGTFPPAHIEILSGEVSGAPLVETDTAPASSSMSEERSNHFIYVCRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC26</accession>
    <name>A0A061DC26_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0303780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768660.1">
        <property type="nucleotide sequence ID" value="XM_012913206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC26"/>
    <dbReference type="STRING" id="5866.A0A061DC26"/>
    <dbReference type="GeneID" id="24565015"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303780"/>
    <dbReference type="OMA" id="YNTQNVP"/>
    <dbReference type="OrthoDB" id="3446at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="6909" checksum="4832EDF2E4CBED0B" modified="2014-09-03" version="1">MAVKVHGSLARAGKVRNHTPKVAKQEKKKPPTGRAKKRQQYNRRFTNAVGMRPKGPNMQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCG1</accession>
    <name>A0A061DCG1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clu domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768875.1">
        <property type="nucleotide sequence ID" value="XM_012913421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565230"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305930"/>
    <dbReference type="OMA" id="YLHFEHG"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="1">
        <location>
            <begin position="134"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1372" mass="151629" checksum="93F7C72495C4A922" modified="2014-09-03" version="1">MDPSASRFADPLKDYGFDPYSVAQAAAHREVPLDETSIEILNGLVGLTGSLNLFPADPFEGVSTPGSCRSRRLDWLRDLGAHSGNSDSDAYEDVYPEDLFEGASLQSKLEFFMFGRHESSNEYHSSYDSWDIPPIHPVRPSLKTPGDSGFELNANWYERIQLAYRSALPRSKSHKSLNLLGSDAEHELLLELGRFSRAACYKATALVLSILQHGLSVYLPGYMSVTEDTLPLVNKFYQKKFACDLQYVHDGVVYTVVVGPVDADNAVPYTVAKKLYCNDQKGKQALCEALYSRGTHGTFAIPVQCIVDFAGIRVVAEPLVPLEDSPPVDLVSELLMDCRAPTGVLATDISSCILASSELFESFRNISSYLHMCSWPVPFDASDICGTSLKGDSDSGEWRSNANNVLCDGAVANVQRCDGVLHIRQAHEVLPPILERNATPDPLYSVRFRPEFCFAYNGSLKCTLKSASVFSDVHSGDLFYEAFKHLVVVLEDSVGRCNGLFDSWDLRQVFASHGVNMRFLGMAYERVVYIGLKNLLAADMVARAMKHLWNTQLEDFFSGNMIGCDALMRRMLKLVNNVFGLYAESAEFWSQRIIPEVARHFNLVKLDGISYRVIPHLLLKSALEYHLCILLPFPSEGHSYRSPITASDFRSVDMPPILGQHRAPHEVPEMHVSDASYHSVLDAFFPRVSVVYPQRELALTKAASSLCGKNGDSVLADLVLATSSWQNGLCRQIEARTLGVGYPCDPACVYSSRLACVNYQQPVTGVNLFCLTQSLLQVDPLKRSKLLLLMGYEYLRHRYIDAALECASYVAKHSPALCAKRLEAQLLALQCHCLKAHEAVSTDLFESLRDEVTGVESCQGLLSLQVFLFMGIAAWIRNEYEPCASYAARARAATLGISGIEEYAWLPVAVVSLLGHCQNALGNGVQAIKTQREVVRLCNVAKLPRFTLCNQTWLFVEYLLRNDSHDEGCALSMECIPILEAEFGSLSVECLRGLYVSAWSNHQVGCGHLLHPLLYLSSSDRVIDANASLGGIRGALLLEEFSLAEICDLRRTHCANALGLYNSLYERLCMVIARSRVDILEYMRTVYPDADLRPVESLHRLTRRRLEAAMEEVPVSDDVLLSGMAADCEKFYEKLLLVIRNMLTLRLLSLSSAESMAVAQRLYSAYVSQVSDKYIAQMFTHGDGDGDAAGEVARLDSTVVGRLPGRSAAANGVVSHALSMYGNSLDRQPEKFNASVSIKQNSVPHRGHELRAIEELLLMAPSTSVADLCETCRLALHGSSDSPSEWFDKIFDIGPSPHRPSERSLPLFLDVLRHFLTPSKRLIILGQVANLNGVEVDATLTFAELHDALVAALGGNRPSRGGPVGTRQQQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCG8</accession>
    <name>A0A061DCG8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767736.1">
        <property type="nucleotide sequence ID" value="XM_012912282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCG8"/>
    <dbReference type="GeneID" id="24564091"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207080"/>
    <dbReference type="OMA" id="YRTINKM"/>
    <dbReference type="OrthoDB" id="365999at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="603" mass="65292" checksum="42319527D28BFF06" modified="2014-09-03" version="1">MSVSKFGDDFASGRFIFELTIHEIRLSCKHSIDVDLIWTAGKQRSQTGAVITLLPNVSTHNVDQKLLIHQTVSSNRPSLKSLIQVVVAHRYVKSEVLAECVIDLADLFHVKHKSAISVPLDTKLDAEASLTFSVMVTNFSFPGSFHTVASYCGLEDSAVESSTLSSVAESVLEYQGLNATGEGTGSRPNGLRRLESTDIYRTINKMATKLSRIESDIQRKTLKLHKINRKNLDGVNGIRSRLENQIALKDQQIRILTIQLDEMHTALALSHERELELGGFVIGRREFSGNDTLEFRETGLSKVGGFTDSSSLRYDFHRNGSAAGSSIRGSERHLTKYDGAGARFTNKDDQLSLLHNQRRTPSWHSCDNAEDLNRRMPHLGTQVSKSGYGDTVTSGVMPANARCEKQVVPLSWVKGTISSDLNASRGIGRSTSATNPVTTALPFVGQRASMDRKATPLLSALQRGSGREIQASKASIIRELRAPCTTALPLGKAPSLIKRNPGARLPQEAGAVMPELPRSTIRPSAHSAAGAAAVVASTPAQQPAAASAKAGAEKATAAEVADDRDTTIVRLERDLISTKVALADSETQRDIEIAKFLTATAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCH6</accession>
    <name>A0A061DCH6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchored wall transfer protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0207265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767756.1">
        <property type="nucleotide sequence ID" value="XM_012912302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCH6"/>
    <dbReference type="STRING" id="5866.A0A061DCH6"/>
    <dbReference type="GeneID" id="24564111"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207265"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207265"/>
    <dbReference type="OMA" id="DIGCGFM"/>
    <dbReference type="OrthoDB" id="361585at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19549" checksum="E44EB88017E81296" modified="2014-09-03" version="1">MDIGCGFMIIQSGSMSSFSRSIRKRTFINILTRHWTLFLLGFVRSLATSAVSYDVPVEEYGVHWNFFLSLGVTKIRKSQFSLMRVLLLSVIPESLVNLVPFVIAFVYEWLLWLFDAVHTVPAIVRTNLLTANKEGIVAVPNSVSLFFIGYCGARACGKVYRVRGRGVAMVFSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM4</accession>
    <name>A0A061DCM4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767841.1">
        <property type="nucleotide sequence ID" value="XM_012912387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM4"/>
    <dbReference type="GeneID" id="24564196"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208090"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="92" mass="10498" checksum="27F3EA16AD9B4C50" modified="2014-09-03" version="1">MEIPPAVPGACYRCCKSGGNDESTPKMQARDSKQPADSYVIMVDATTVSLFIKCFSSLTRRKHLNARLRHEHLLLLIDTKLLNLYLNRERIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCS6</accession>
    <name>A0A061DCS6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769045.1">
        <property type="nucleotide sequence ID" value="XM_012913591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCS6"/>
    <dbReference type="STRING" id="5866.A0A061DCS6"/>
    <dbReference type="GeneID" id="24565400"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307630"/>
    <dbReference type="OMA" id="IHEIVKY"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="181" mass="19762" checksum="E7C335C019ABF8ED" modified="2014-09-03" version="1">MATAAKHVQLLLIHELVKYYLARSLRKRSSSPQSAEPQSQSSDGHASVKAALDLHGYYLGARIATRLTLGKGRIWDQNTCVIFVCKNVWTYLFGTNAGRLQSNSQGTYIIMCDQIPWLSHLGARAPVAGGSDGLGFSEDYKLFYLHLLAGIVRGCLAALGLSATVSPHMDDTYKFKVSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD29</accession>
    <name>A0A061DD29_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768086.1">
        <property type="nucleotide sequence ID" value="XM_012912632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD29"/>
    <dbReference type="GeneID" id="24564441"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210530"/>
    <dbReference type="OMA" id="NKCYPKY"/>
    <dbReference type="OrthoDB" id="365146at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="742"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="961" mass="106328" checksum="3A0C04B8C976158F" modified="2014-09-03" version="1">MEDSSATMSTEEKYKELKRKYVTLKDAVKQLHDDYERVKEELVAKTDACECLEEQNQNLKKAYDELTDEVSNIKSREPAKSAPFKWENALTLIKKGAQAASNGSSEDVSLLHSEIGSLKTQLEAAAHEKEELLKEQNALRTEKDSQSFEYSAAVAKLKERIFALEGILKELQESLTTSESKSSNYATEIAELKSTVASRNSKLEKLEDTLGSERKFLHRYVNLLESRLRSKVTYDIRRLPLVNTFNIYHHQHLHNWSLVRHAVDDMSVSLLLSLKGLFGAWKSAMRFIRGSDVVTESVLQRSPPRGAVDTVNAAKSSASQSPNPSLPNPGHSGDGEAVNSSAEVAGESPEAVELEATDNIASVDQPSSSNEGHLPATDGLFPFALHDGDNNKHIWLAMESYRQMSVATISDLVLSIDRLLEGEHLPAAAFRRSVRLVRTLSRNLRLYLCLEEYLSPYEDVEAVVMGPRRVRQGTVVFIRCLRELCNAVSRLFTIYGCALSRVDEISKEELSELANILSAEVGEPASSDLARARAPSDAIGATTRNLDSDAAHSLHNDTGIADDNVLEPGSDDASILGGVNSSERLRSLTDELSSSRPLRSLERRVFSGLKDVVGIVSLFKSVMSHRLCYPKMLDGFFFPLSGGSPEMIDLGSAIADFETHIARVTEHIVSLRLHGALQMRRNSVCCPRAELTSALTSEAITGKSSTTSKHVVPLFVGAVNAQLLSSPNRVCISTVSDRIRMAEEERREMSTCNERLSAMNEELMAARARCDALESRLAESYGLSLKEERLVSEFERLFSRYHYHDKQLSMGGFAAHSHHSDLLTELHALREDSGQKMKKLAVYVRHLVKSVEQLEDSNRQLRRALSLHAEQYAESKAAAESVHLNYNEQIALMSEHISELNNSIVQAEYRVSELSGAMITCPACRSKCSLGALLHLEALFAFQVTWSATTTGEGACPARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD43</accession>
    <name>A0A061DD43_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell differentiation family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769270.1">
        <property type="nucleotide sequence ID" value="XM_012913816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD43"/>
    <dbReference type="STRING" id="5866.A0A061DD43"/>
    <dbReference type="GeneID" id="24565625"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309870"/>
    <dbReference type="OMA" id="IFIVQKF"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000661">
        <property type="entry name" value="Cell differentiation family, Rcd1-like containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="325" mass="36714" checksum="72D2631E4F2E601C" modified="2014-09-03" version="1">MQNFSFDIDQGDGLPSNLLGEGLPPGNSMSQKPGVATAAPPAQEKVPEHILHQLILDLAIHDKREYALSELSKQREHYPDLPLLLWHSFGTVATLLYEIVSVYHYLYPVNLSMTDSTKASNSLTLLQCIASHPETRRLFLSAHIPLFLYPFLNSTCKSRRLEYLKLTCLGVIGALVKSDDEEVICFLLDTEIIALCLRIMETGSDISKTVAIFIVQKIMLDDRGLAYVCATAERFYAVAAVLNSMVMSLLESPSRRILKHVVRCYLRLSENPRARDMLRKCLPKPLRKIDPVFYPCLKEEPMLKKWLLQLICDTEPAQEPSSPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD93</accession>
    <name>A0A061DD93_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0212120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768256.1">
        <property type="nucleotide sequence ID" value="XM_012912802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD93"/>
    <dbReference type="STRING" id="5866.A0A061DD93"/>
    <dbReference type="GeneID" id="24564611"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212120"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar GTP-binding protein 1 Rossman-fold" evidence="3">
        <location>
            <begin position="541"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="648" mass="72803" checksum="3EE2899A2A2463D2" modified="2014-09-03" version="1">MPWFRIGSGNYDGALGGTTSHYMSQCGVSKGGFQAKSSVPAHRDDLNLGATDAEDGDVAEDSELEIQRFIEACGGWGSDEDYYSDTNAELQNTVDSESESYHELLDGSDEHPDAPDETSPDAVIPSAVRPQDVFGGEPYAADSTNEGAVASRSGTQDQELSYTTPPDEEDASDDSEPVPFRLITAEDKVKNLLSQRLYVKKLFRRIPQIGDTTSVLVRSKAHVKGKVGSRSELAMGNANKIKTVDTPEEPVYDGKPLYAGVYNGLTPQKHTKKRVLREIKVKVDWYAHSITHQIKNVTTFYEQLLRYIHPFQYQMLMTAIYELHHTRQIKLPFDQLMEALKALKTNIVTRANNFNSKIGSIKKCREAFALAKAFILQLDEAYKEAEPYINIYRKFATQFRKLPIINNAKPVVAVVGYVNVGKSTLFQKLCNLPMPTVTSIDVEEELPNPLGLISDVLGLKWQENSAPPVKVSQKEVKIADYNFTTKSLNLANVQYRVDNFIDEGQLLDTPGLLWRDKPKTNPYEKLTVRFTPHESHDPQYATLKDLPSGVIYCFDVSDKTKLDNQIKLYRTLEARFPHRPWINVISKGHDSQLLADEVRAHVAFQPHRMQGIDVIPEGQVLERLYSMFDTLDGLLRMQRDAPTAANEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDC8</accession>
    <name>A0A061DDC8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769470.1">
        <property type="nucleotide sequence ID" value="XM_012914016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDC8"/>
    <dbReference type="GeneID" id="24565825"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311870"/>
    <dbReference type="OMA" id="YHGKIIT"/>
    <dbReference type="OrthoDB" id="405860at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="191" mass="21867" checksum="15E5CC84C2E29109" modified="2014-09-03" version="1">MASSGLIRASRKLHNGKHLFIGNYRDFGLWEFVAPPRLQHVIVPIEKEVGVRSPLVPESGSVFMHMKDPLAHLNGDLPSKPLVTVDDITPPGKVLRGSGLHGPERTDVTRLVLYNRLKARQLQRLVPSKHEAEEDHKLMWCSLWFTLSSTIALHYMYKYGLDYSTIHEHYPWTPPRTDGSRGPGPMYWIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDD7</accession>
    <name>A0A061DDD7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0311970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769480.1">
        <property type="nucleotide sequence ID" value="XM_012914026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDD7"/>
    <dbReference type="STRING" id="5866.A0A061DDD7"/>
    <dbReference type="GeneID" id="24565835"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311970"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="401"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="601" mass="66839" checksum="EC99E11191127FF6" modified="2014-09-03" version="1">MATVEEITSRFVALNARREAIDAERAPKCAPGARIGCCTYPADLIEGYVALNECILGAPGGLNDAAAQAATAAASHSLSVLTDERVMCICENVLYVIVYHLIETKQTDAMLGALVRNEAFFCVLPQAKTAKLVRSVLERLSQEVKDLDVLYKVFSIYRGWCESKKRTFLGLRLDLKIAILLLLRRNYTAALSTLDRLQQEVKALEDKPLLLDIHLVQAKACLLVRNLVRMKIALSNAKNIASNINTPTYVNAEIDLLSGLVCLSEKDYSTAYSYFFEAYEGFHMAVGGTHSVLFPNLARSKAKAKVLGELTAADTAGPALVSSAAVSLMVGEGELYSCHAAISDISPVFFSFYNLTEYKRGAEADKAVGDVPAVDACSSHYLQYYGMLNLDLAANGPENAEQMHYESGEEPLDVSVLARADERKLVQALKYLLLTIVITGRNDEMIPLLAAKNKQKFVNHVECKMIQRISACYKNSSLVEFEKLLTEYKQVILMDPVLQQEIHRLYEALLERNITRILQPYSNVQIDFVANKLCLPQQKVEKKLAEMILDGKLRGTIDQGQAHLVIYDEEEHETFYEDVNQTIGHMTKVIDTLYEKAQRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDD8</accession>
    <name>A0A061DDD8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0312020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769485.1">
        <property type="nucleotide sequence ID" value="XM_012914031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDD8"/>
    <dbReference type="STRING" id="5866.A0A061DDD8"/>
    <dbReference type="GeneID" id="24565840"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312020"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="114"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="503" mass="56723" checksum="E1F4E2697D79D4B2" modified="2014-09-03" version="1">MEDAGNFIRVTVKWMGKRFNDLEISLDDNVEVLKAQLYSLTGVPPDRQKVMYKGLITESTNLREKGLTNGTTLMLIGSPDKLVERTEPVRFLETMTPQEKSAMLSSAKMKRIPCGIMNLGNTCYFNAVFQFLQPVTELWEGIELLEAKDAIDTKSDRYQLTKSLLDMRRNLPSTLTRYVPLQQMQLLRRVNPIFNRTDEKTGVYMQQDAEECLSCLLSCINGLSDNKLTDELFGYTLSTTIQPKERSDPAATEGSSVTNESNFKLNCYMGTQLKSVGTLMDGIMISLNEDIVKFSEQLGTDVPHEKVARISTLPKYLIVHLVRFEWKQESKVSKTDAVKAKVCRRVNFERELDITSICTEELQQLLHEANAVAMQLDFNMGKTNRTAPFKGYEMYPGMYATGRYTLQSVVTHQGRTADGGHYVCWTKDNNEAAPTEDSDSDVAVDDGWLMFDDDRVTEYRWGNFDLCGGRSDYHIAVLLLYKAQCVSVDAEEAPAGADDAPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI8</accession>
    <name>A0A061DDI8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD domain, G-beta repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0313610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769645.1">
        <property type="nucleotide sequence ID" value="XM_012914191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI8"/>
    <dbReference type="STRING" id="5866.A0A061DDI8"/>
    <dbReference type="GeneID" id="24566000"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313610"/>
    <dbReference type="OMA" id="GHINERM"/>
    <dbReference type="OrthoDB" id="366376at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="94230" checksum="52E3AF5608935268" modified="2014-09-03" version="1">MVGTTATSDQDGMMDYEDSMSTTEQEPEPIQVPKKSAVMKMLKKMELGDVYCVKCIRRKKIKPAMDSALTGDELGDLYDHLATGNETEKLETTRENDEASANRGTAFFNKVGDTHEHYMKHFAAGSLVDDVREDETTDSTDMHLDDEVTEPVNYPGVSPLQSSVFCSMEEIRSNESHIPPETSMSAQISIDMQSAQEGTPYTTGLVSTLSAIDEPVSDQPVDTASDDEGAMQSVDMVNDETTHSYIAPETATLDNIHCGSDSTVEKLDIIGTKESAPVGELMGELTAVMIRPTEFSSREKKDVPMGTTVTTTKADNSVTPSTAADAFATSVTPKETPLAPTAETKIKPDGPIGQHVDTRSNPASAESSSSVAQLKRADAKDYGAMVDADKKKSVASVLTATATQKKTAPKLLTMQEAMQVNAKAGALSAMTLSPGKDVLALGTERGILTVFITAEADMRNTRRKKQKPADVADNDPMPDSMLWGLMAISPQVSTEAHLTAINNIRIVDIELDGEGDARAHTNEIATIVTSGADTYVRVWSLHQVSNEYMLTLIGAQVMGNEPVAAVPNFAHDQMLVAFADGLIQHWKVTDRGSPEMNRQHKLMFSETKGGLDAMCDVLSVDVSPTGQTFAVESAAGWLVLYDSKTKKEVGSADCRNGRGKWSNGADVTGVDWSKKENLILVTTSDCRIRMLTATAYEEGELLDLEKFKGHHNVEMPFKAQFANNDEYVVCPCENGFIYVWKINVDTSKKNIGEDDMQPTNSQFVRFKFNAPKILPHLAIFDPGEWKHLRQMIMQQEKNGVTDVTQMPQASCKCLPFGKHFTTPQSIAVADLDTQEHILLVAPENSGFLRYSLISLAVLQRQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK3</accession>
    <name>A0A061DDK3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0302240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768506.1">
        <property type="nucleotide sequence ID" value="XM_012913052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDK3"/>
    <dbReference type="STRING" id="5866.A0A061DDK3"/>
    <dbReference type="GeneID" id="24564861"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302240"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="552" mass="60030" checksum="BC9FC18A4DCD3F2B" modified="2014-09-03" version="1">MASSQFYGEVTPEVLKGGAQEDKGETARMQYFIGSIAVGDLVKSTLGPKGMDKILQPMNMEGPRGENVITNDGATILKSVWLNNPAARILVDVSMQQDSTCGDGTTGVVVLAAELLRNAEKLIEQRIHPQIICLGYRRALQVARKRLEEITFSSVSNAEKFESDLFKIACTTLSSKLLRHEKEHFARLAVNALLRMNRDVKEHGGDLKDASSHINLSLIQVIKKPGGSLKDSYLEEGFILEKTIGVGQPKSMTDCKVLIANTPMDTDKVKIYGVKVNVDSFEAVSALEQSEKQKMKNKVDRILRHGCNVFINRQLIYNYPDQLFKEAGVMTIEHSDFDGMERLAKCLGGEIVSTFDTPEDVTLGRCDKIEEILVGEDKLIRFSGCARGGACSVILRGASSHVLDEAERSLHDALAVLSETISDGKVVCGGGCAELEMATAVFECAKTIEGKESLAVEAFGAALLKLPEYILSNGGYDAADVVSKLRAAHVSGNVHAGIDIERGDVGNMMELGIYESLKSKMSQVCLATEAAETIVRVDDIIKCAPRERQPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDL3</accession>
    <name>A0A061DDL3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0302540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768536.1">
        <property type="nucleotide sequence ID" value="XM_012913082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDL3"/>
    <dbReference type="GeneID" id="24564891"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302540"/>
    <dbReference type="OMA" id="CINLIIE"/>
    <dbReference type="OrthoDB" id="329761at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="262" mass="31032" checksum="D4DC382B7DE9E3EC" modified="2014-09-03" version="1">MTKQPLSTILAGRAREVWRESIRRARQDIFGRIKGMPGENEWLKPLRGRSRTRWYWPSKYLHMDFTLQHYLAMQLKRMEAREDHPSIKKLWDTVRIFAANKSHIEKFMETVDHETFTRSATLHDAQALLTMIGEKSGGQEQLNPATNETLDADRFRPFVQYALSPLRGIPRHLQASNLRKNNTKLRHMLASDGTITNLWTVRNRFVDALYLRRRAYYLAKLMRKKPISETIQKYRKHFTVHPDQKVIWPDNKGISQHSWPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDN8</accession>
    <name>A0A061DDN8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">-Protein CyaY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0400660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769760.1">
        <property type="nucleotide sequence ID" value="XM_012914306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDN8"/>
    <dbReference type="STRING" id="5866.A0A061DDN8"/>
    <dbReference type="GeneID" id="24566115"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400660"/>
    <dbReference type="OMA" id="GSIFANH"/>
    <dbReference type="OrthoDB" id="365372at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="119" mass="13552" checksum="45C7EE99644B89CC" modified="2014-09-03" version="1">MLRLYRLFSGVANLHRFNEAALNQLQALHDTLETVDDISSISFDGTVLTAEIDPKQYIVLNKHEASQQIWYSSFNGVDYFDIEDGKWLSRRTGRHLDAVLKYDVQQATGKAVDFANAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU4</accession>
    <name>A0A061DDU4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spectrin repeat superfamily protein, Extracellular matrix-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768766.1">
        <property type="nucleotide sequence ID" value="XM_012913312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565121"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304830"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1816"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="809"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1878" mass="210361" checksum="50CBA4F224752FBD" modified="2014-09-03" version="1">MAPKKLTDCPENLREAIDWLIQVRHGGDGRGLERLSGALKQLIDEAVEKAKETMKHKRRKLECANDYYERPYCTELDEMCAKAKEKLKEFVSGKNSVSDKNALESKIKHHESNKKDCINSHDIYDRRKDEIQKEINNAEQVVAKLKKFSDRLDEYKGTDDNILNTICDGLEHFLGYNSKNYNGHGIVYGDSDRFRDAILMFLHGVLECARNNPNIKNVDAYIFILNPVIQSLYSARWNGKDGFDSAVQKVIEGVGKYFDKVKEHDALVMNPITDLIGEIDEKLDMSDYTKTLTLAEQLEQLNGSASSYNSLATDAEEALSNIDEEHKKKLEMPIQIMKQSVENFKQAAGNIDLAKQCKDVDEKLKSLPSEVNSKIEQAVAQFIKDHEKYIEHLKTGIVHDFEKRLNGWISRVDAALEATKTKGVTSIENLQSEFEKAIKALHKEIKDRVNKIDVSNLSTNVSEFKKSFSVVEEQLKKLTKDDGGKIPKGLLQSTEETIKEQLQNFVIQAHQVNDQLTNIKRSLNGWLTKNNDADGNPDGLSALSKGVNEKIESFKSEYNTIHEKLDGIKKFVEGNSDNQTLEGLISNITAQVNALDDKVAGDLNGLKTRVYAAMKAVIVDFQKGVKALADSDSGSSSAHFIQDFRIGMRDERSDAKSLVAWTKAAESGGQLRSALEQLHGIDRDFTKLRGVLEALGDFKDYSTKTFFDAITYDLKDKVAQIALALNNADAVPVKGQFSTTMVQYKNHVGRRGQKSTTTIHGVISAVSESVMSLGEAYSGTTKADGVLKELVDTLPAQMKQLTTSVEEVISKLDNNNTHLEKIVEEAKRLHKELQEDYKNGLYKKFSALREAVNVSGRQFDEVKYQLNTVLTEAKLQLEALESLPDKIKNAERTGTNALVATFTKEVMEIKIAANKLGNEKKEHCINDTKNVLDSAHRSAAGYIRQLGRQCIAAVTHAFKEITQHVQSQYASSNNAQYEALKRCVAAQKLKITTIMENDLKTGLKGFLKTVSGVAANSQTISGTGNKIAELKDMNNVKDLSVKLKAYLEQIFYYVIEQLNLNPTSGRVGSSEHSARSKSPLNDPNVSDIYTIYKIVNDVMQSLAISNSFNHAIRDKIHEAYLAIPKFVPSKFFSMPSNPLLDILKSGFDGFAKELKNVYVSKYSGATDTFNWDIFGNSEKCAKVCSTIFEILHRDLTKLKTICEGGSNAKQINLQITLDSGRKVVNPLGDFFNQRGYKVPSGASTQDAELRNETNIKGEQIKDLLYENYNIFASLHSGDDNALYDGPLEQLYNNLLDYNRVCHLRSIKNATSPHNAFQMLCWLSGLQYNPTYHPLKEYMKTFFKKAEKHKDTEYSRIPFVDLKVEATSPFSARDTVSALRLVTVQSHDILTTLLGHGHASGIYACDFNSNPGNLSYPGDSGACFDLLVEILLRLNHQLSFLYEQCCHTTKVSGWSDCWYGKGIGGSNWQCNDLKCTECTGADKCRNHPICGLKSPLQSFLEDGLKGFLPHTFTKLGCKLECSVSNHNGIPCITPMGFSDIGTVASHRQTGERIKDVLRSFCGNENSPLNQLCSYLMCLLRTPPRTLGEMFAFYYSFLHDWNDSGAHRKDGFNNAVIKANFGHSSTRFDISSMFKNTDHADNHLKGDLYSLISCSNTYIPARPCGPYMRPLCLFSRDLYSKEYSGYYLSWVVYLTETFYDLLKKLYEDCNKSCGSKGSKCYDKSCVRSCPISRDPSSSAHDPLCKSMVDCTSTLPTLCKYGFYFGSATLASGSKGDTMKRTCKEFIQQLRNVCDGNSVLAKLVNITIPQYLFTIRSPFFWTTLTLWLLSLLYLIHIMVIRLDLLHIKSHLRSPSSHRIAAQSLLAAARVNKLAKITYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE10</accession>
    <name>A0A061DE10_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Importin beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0403470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770045.1">
        <property type="nucleotide sequence ID" value="XM_012914591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE10"/>
    <dbReference type="STRING" id="5866.A0A061DE10"/>
    <dbReference type="GeneID" id="24566400"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403470"/>
    <dbReference type="OMA" id="QQYQERW"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="859" mass="96086" checksum="69C72DF04DDEED65" modified="2014-09-03" version="1">MESNLLNILATCLTPTSATFAEAQRQLGEMRKHQLPEFVRALCDVIANAHVNSDIRQLAGVLLKNCFERDPKSSDPNANVLLQVPEDSLRYIKVQLLNVMKSGGESQSVLAACYVISRIAELELRRQGWPEFFDIIIGMMDSNDVEACRSSLKCVQYLIEDLSSVYYSHGTAFLSKSECDRLLTSIVKGACMADDRSRKTVMTCMQHILPFVGSNMAIPSERDAIVRAICYNSAPGNGPDVRAAANDCLVQLITDYYELIGPCLQFIVPLLWQAIDTCVDEIAIPAFEFWNTICETEIQLEFENPDANQHIIQQVISYLLPKILHTMTLHEYEDFDSDTWTLPMAAGVCLSLCSQTVRNDIVPSVLQFINDNFNHQKWNHREAAVLAYGYIMEGPDAETLQMLVRDSFDRLCDVMDDPSIAVQDTAAWTIGRIASFHCQVILPYLGHLDDSNSNLSKIMRALFKPARVAANVCWFLHELAENAVRASGNRDLIDAIFPKVCDALVRRASMDDAMEKNLFSSAHSSLCNFISNVSVRCRKQLGGMLEHFERMLSQSVSSEDQTSETRSRQETICGVVQVLLTHVEFVPSTQNLWRNLYTILQEDLSEDALLTVSALINRVGSEEFQPHLPQLMDIVLAGLRRPDMVDSCKACVELISDMSRVMDSSMRPYVPQMMDILLSALADFNTPQKLKPPIVTALGDIAIVAGPAFAAYLEPSMNLLLQAASISFEMGPVENEEWIWYITDLREGALLSFTGILYGQKGANQLNALRGYVSSILQFVQQVVDTPQHYYSSCNYRLAVALAGDLVTAFGADLSVHLVNSTLMNKIMERLEQLETENEPSVPECREKVNWLCKLLNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEA5</accession>
    <name>A0A061DEA5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769161.1">
        <property type="nucleotide sequence ID" value="XM_012913707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEA5"/>
    <dbReference type="GeneID" id="24565516"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308780"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="77" mass="7868" checksum="515AFFD181F4CE1F" modified="2014-09-03" version="1">MGTSNVILRDVTGSAADGSHLAANVAPVGDHQCPCLRLRGVGAAVVEGTGSGSGDWERQWLRSAGGEDVERGSVYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEB2</accession>
    <name>A0A061DEB2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769181.1">
        <property type="nucleotide sequence ID" value="XM_012913727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEB2"/>
    <dbReference type="GeneID" id="24565536"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308980"/>
    <dbReference type="OMA" id="TINAFFI"/>
    <dbReference type="OrthoDB" id="361979at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="387" mass="43376" checksum="2DB630CEE20B5475" modified="2014-09-03" version="1">MAFRNTTEHSYNLSVVTLRNGEFVGGLRHTTSYRKISGPGINTHRPTALGLFGSLTGWFSNAIGSRWYVPPMPTGKFASTILRKHGRLQTEQETKDFFDLIGAHPDSDLVEIGQAYEHAVETLPEDMREVLKRSFHEFLRKQFVEAFEHMESFIKRGPVAWEEYWDPSKDAYGNPVVSKFATPEEEDEAMAASMPPEFDVSKFREYWRKNSSQFNTMMNKVDMASRVRLTSDFGGRLLKCTTTMIPVMIMGLFPQFSSMSVAVQGLLASGFIFKGDRAVILEREKKSLEPGLAAAPPARSPSSRTLLTSAVLCVHSLLGIGAAKLMEHYTSVLDHLTPQILKVASINFQFLIAALLWDTSDLTPSGHAKREERRMSKITDTLGDIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEB4</accession>
    <name>A0A061DEB4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769186.1">
        <property type="nucleotide sequence ID" value="XM_012913732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEB4"/>
    <dbReference type="GeneID" id="24565541"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309030"/>
    <dbReference type="OMA" id="WYTSKCI"/>
    <dbReference type="OrthoDB" id="361873at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="148" mass="16272" checksum="D0082CA6D62CF84C" modified="2014-09-03" version="1">MASWAIHAAHESAGRGEAGAVDASGRGEVVEESLVLLDFPDFLTTSVFDGAVFRQVSEDATGSTYAIDNCNFNSLRLEGLDGAEPKCVLNGQIPFKGKRVSEGVTYFCFDIAEPNAESETNHNEPKRNAPYLREYWHTEKLIQFNTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE3</accession>
    <name>A0A061DEE3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769316.1">
        <property type="nucleotide sequence ID" value="XM_012913862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEE3"/>
    <dbReference type="GeneID" id="24565671"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310330"/>
    <dbReference type="OMA" id="NEYINFR"/>
    <dbReference type="OrthoDB" id="363392at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="23980" checksum="0F823279E37D2094" modified="2014-09-03" version="1">MSRKQEVVPSTHNSLDVLPEIFRNEESSLLIQTYPLEMVKRAVGEIAVCLSAFTHYAREYRDALAFAPGDTKKLFKQKLLMDYYALCYLAGSKNYYLYNTHRMNLIKELAVTYNGLYDVIPMNVIERLSDQEATFLRDTCNSIIKAPLPVRPKSYSIIAILKDIVTDDIADRNNPNMRYYPKGAKLTVPTDMAELLVQSNWIKVIKTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEH1</accession>
    <name>A0A061DEH1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0311730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769456.1">
        <property type="nucleotide sequence ID" value="XM_012914002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEH1"/>
    <dbReference type="STRING" id="5866.A0A061DEH1"/>
    <dbReference type="GeneID" id="24565811"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311730"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="409" mass="46215" checksum="C5FDE50B1D76B2C9" modified="2014-09-03" version="1">MLDFLILVLVRVFAQATVYAVAPALPFFVLRESRDVLEYIALDAASRLKFFENTSHFIYSFTWLLTSAVPQLPALDVTKVLILLVDIASAALWYNTTRLLSNSGLEKNKHASSPLFIAALHLLNPFSIMYNEGCNADSVRYFWVSLATFAAVNINVERGAGIKPYVIYQLAASGFLINGVFKMYAVLPALTMVAVHNRLQQSNEPSITWKELKQMFAVICPHIFLTLSIVILYYTARGESVVKRALELEYTGRGTGIDYSLYWYLHRVLPAAFEATNTFKSQMMIFVLPFPLLVLLRKRPMECLITTFVIAILQHPNLSLLGLWYIVCLCALHYPMMDKTIGFTKMMMVAIGAMCFSVTAYVTWVGRYIANPNYFFAPQLLIFATICILLEDYTKATFQLSNSTSQVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEL3</accession>
    <name>A0A061DEL3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769666.1">
        <property type="nucleotide sequence ID" value="XM_012914212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEL3"/>
    <dbReference type="STRING" id="5866.A0A061DEL3"/>
    <dbReference type="GeneID" id="24566021"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313820"/>
    <dbReference type="OMA" id="TIMDNAW"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="223" mass="18760" checksum="C7E43E0F3CA6535A" modified="2014-09-03" version="1">MRGLGAAVVEGSGSGSGSVAVGECVARLRGLGAAVVEGTGSGSGSVAVEGTGSGSGSVAVEGSGSGSGSVAVEGSGSGSGSVAVEGTGSGSGSVAVEGTGSGSGSVAVEGSGSGSGSVAVEGTGSGSGSVAVEGTGSGSGSVAVEGTGSGSGSVAVEGTGSGSGSVAVEGSGSGSGSVAVEGTGSGSGSVAVEGTGSGSGSVAVEGSGSGSGSVAVGDCCLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEP0</accession>
    <name>A0A061DEP0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769801.1">
        <property type="nucleotide sequence ID" value="XM_012914347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEP0"/>
    <dbReference type="GeneID" id="24566156"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401070"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="16987" checksum="AC138184B29C74CA" modified="2014-09-03" version="1">MDLGRHGSYPPPHVLPWVVRLRRAEQRLHAKQHRSYLQRGAPLVLQDVQAYPAELVDVRVVYAGEESHLRRLHWVLLGEKQLEFVHTSLVGCALRSQHPDVEVPVVSGVELGPDAGCCTNISVSGEMTSTYANRSPNFRFPSVSVWASLCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEQ7</accession>
    <name>A0A061DEQ7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0401920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769886.1">
        <property type="nucleotide sequence ID" value="XM_012914432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEQ7"/>
    <dbReference type="STRING" id="5866.A0A061DEQ7"/>
    <dbReference type="GeneID" id="24566241"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401920"/>
    <dbReference type="OMA" id="ARKMKEC"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000398">
        <property type="entry name" value="Calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="149" mass="16696" checksum="8EF3C599C91209D4" modified="2014-09-03" version="1">MADQLSEEQIAEFKEAFSLFDRDGDGSITTKELGTVMRSLGQNPTEAELADMINDIDSSGSGAIDFPEFLILMARKMKEGDTEEELVQAFKVFDRDGNGFISAQELRHVMTNLGEKLTNEEVEEMLREADVDGDGKINYEEFVKLMISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEX1</accession>
    <name>A0A061DEX1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770206.1">
        <property type="nucleotide sequence ID" value="XM_012914752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEX1"/>
    <dbReference type="GeneID" id="24566561"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405050"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="65" mass="6823" checksum="39ECD9F910BF5F45" modified="2014-09-03" version="1">MDKARNNTSGKNGSSQVSGTNVDSSTTKKSTKPRKQPKTVSAIGSKNFYYPGVPTVANLDAGSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYI0</accession>
    <name>A0A061CYI0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765892.1">
        <property type="nucleotide sequence ID" value="XM_012910438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYI0"/>
    <dbReference type="GeneID" id="24562247"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100350"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595788" evidence="2">
        <location>
            <begin position="26"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="284" mass="31592" checksum="C6D51DC7368BA6D6" modified="2014-09-03" version="1">MASIRYGGRLGLAYMVCFCLAVTNGLPAKDHFVYVVSDIAEGSVHYRKNIESVLRDGATLSVLNTILDTVKRIDKALNGPVFNERKVLSLIKALLPPVDDFSSAISTWYDQWPQILELFEGAMRTYKRYHEIDASLKDLDAMGPKRSELTREKVKLEFEFLRFAPIIDLYITFRFDLTAPILVHLIDDIERAFTFPTPLERPSWSLSNIPSTETKDASLSPGATNLQSSTTDEMGPRNAGTESYKWSTFGNVRERRNARNPSGAAAFSLGAIVTMTAATVTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZF4</accession>
    <name>A0A061CZF4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyltransferase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0103260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766192.1">
        <property type="nucleotide sequence ID" value="XM_012910738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZF4"/>
    <dbReference type="STRING" id="5866.A0A061CZF4"/>
    <dbReference type="GeneID" id="24562547"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103260"/>
    <dbReference type="OMA" id="RIYMFNH"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
        <location>
            <begin position="89"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="279" mass="31702" checksum="3594B1D1C8E82B77" modified="2014-09-03" version="1">MGAVDYARKLARSFVFYSICLVTYLTSVLVITLYVGLVFPVYLWNKPAVVKVTNWMFFTCFNLIGFVFNRSWKCVMLNDLPEDYKKKQRIYMFNHLSSSDPFLVTHIGMKLPLVCTYKDSLHKIPTTRLMMGLSGQLAIKFMYDKANDRKIPVRDSVGKLMKDCKDAMDQGFNLCVYPEGKRSRDGVLQEFKDGFFRFAVEHGVEIQPCAISNSAALWPLKSTFLIGSGLAYINIGKPISPEGKTVEQLKHATRKAIYDALRACPTFNPALETVPELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZH2</accession>
    <name>A0A061CZH2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766212.1">
        <property type="nucleotide sequence ID" value="XM_012910758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZH2"/>
    <dbReference type="GeneID" id="24562567"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103410"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="11669" checksum="10BD874A3CC1A219" modified="2014-09-03" version="1">MSRMRDSEEAISRMDTDSAIQVHDKLDAGASAHYDDVERGSSADSDHSAESSGITIYHVLSVVLIFLALLVLMLIILKRSTGVCDDELHVAVRRVEYGQALRIVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZL6</accession>
    <name>A0A061CZL6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L21, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0101670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766024.1">
        <property type="nucleotide sequence ID" value="XM_012910570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZL6"/>
    <dbReference type="STRING" id="5866.A0A061CZL6"/>
    <dbReference type="GeneID" id="24562379"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101670"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000002">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="160" mass="18304" checksum="05532772FF22750E" modified="2014-09-03" version="1">MPHSYGKRARTRDKFSKAFRRSGMPSVSRYIQQFRVGDYVDVLCDPSVHKGMPYSYYHGKTGMVYNVTPRALGVIIKKVVRGKQLLKRIHVNIAHIRKSRCREDFLKRVAVNDELKRKAKAEGKKITTKRQPAPVAPGYIVEATPDSIIAMDPVPFVEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D066</accession>
    <name>A0A061D066_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766412.1">
        <property type="nucleotide sequence ID" value="XM_012910958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D066"/>
    <dbReference type="STRING" id="5866.A0A061D066"/>
    <dbReference type="GeneID" id="24562767"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105350"/>
    <dbReference type="OMA" id="HNKAEMI"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="234" mass="26367" checksum="4F2EBA669A3E6F72" modified="2014-09-03" version="1">MEDLKDGITRKETLLKGHRIHLRKRSDIAKDIARYKSKSKTKKDVNTIMSLNAIFKQSKQKSLDVKRTSAICKKNDTPRQQSYKLLLAVRNQRSVQPSISESFLKDMGLSIIGTARFFSNSESSLKSLERVRPFVYYGTPTQRHVKELLNKRGTIILPNGVTRLISTNSVIEEHIGRNDILCISDIVKSIYNGDENAEDILSKLGTLNMSINSLECPLKCGDIGTSINETLDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0J4</accession>
    <name>A0A061D0J4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0106200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766497.1">
        <property type="nucleotide sequence ID" value="XM_012911043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0J4"/>
    <dbReference type="STRING" id="5866.A0A061D0J4"/>
    <dbReference type="GeneID" id="24562852"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106200"/>
    <dbReference type="OMA" id="YNTRIPK"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="267" mass="29548" checksum="D86D99190922F67A" modified="2014-09-03" version="1">MDFIRKALAANCRLDGRRLDAQPSLTVESNVSDVAHGSCRVTLDDTVVITTVSFTVSAPSQDAPDEGTVEITLGSPFSLEDAEVSHKRDERWERTLEWLQFQRQRFDRRLLCILSGQFSWAVRLHSTVLQRGGAFLDAISIGMVIALRTARVPNVQVLIRDELERSRRGANVRVRLAEGYNLDLQKLALQLPICVTVAKIADYHVWAVTHEEAECADGFLTVAVSPEGRCIGMTAVGSCFQLPSIATLVEKACRVGVEQHQYILSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0R3</accession>
    <name>A0A061D0R3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766577.1">
        <property type="nucleotide sequence ID" value="XM_012911123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0R3"/>
    <dbReference type="GeneID" id="24562932"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107000"/>
    <dbReference type="OrthoDB" id="365604at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="173" mass="19403" checksum="C445BE1F6A14975C" modified="2014-09-03" version="1">MEPQPSSGSTQQTYENPRKRRGIAFSQVSSSAVQHQLPPAAVLRNDERHGDISQLENTECYKGKQYTCSNKPVNDLRSDLQVHVNYPCHQVGITPSPTSDATIRIPARQPLSSTAHRKVLGPCGPLHRAVLQADSHNRALEKAEMWKRYRQSIKTVTPKKRDRDTLDRAQASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D109</accession>
    <name>A0A061D109_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0106070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766484.1">
        <property type="nucleotide sequence ID" value="XM_012911030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D109"/>
    <dbReference type="STRING" id="5866.A0A061D109"/>
    <dbReference type="GeneID" id="24562839"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106070"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="622"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="683" mass="77579" checksum="9FAF9BB3F44C0B51" modified="2014-09-03" version="1">MELSREYAASRRPSRLRDHFVSSAQSEPSEHVQDRFGRHTTGRGYYSAQERAHRDTPRRDYSRRYRSYDYEDSYAKHYDRTYIYARRAVYNHEYGEYNMRPKPTPIPITTSRDNGYVGNRVRSTPQAEREDTNFAHNNIMVGSRSTRRATSRWSDVLADPKHSNEADDKMQLRYSYKRRPLNEPVKPIMNDPVPVDSTADETAATLVRVRPLSPRISKRRAASLRVDEEPQATELYVGEHMVTDNEISAVDDGIHAPPDYVPVNLPETPQTHTPEGGDVVENTVIKAEFRTTNNNSPIKRKRGRPKGVRETAVHASPTPKKEKVKSAMAGNDGPVVTPVPKRTSARIRSHNATSSYANDDHLAGDTYEEQLQKAIAMSIIEVDNKPSDVDKTQPDDGDLSVDSNDKDQESSIAVVDDDSGDQDYVPDTPTTAAKKAAAKIKRKYATKTTAKTAVAKISGKVRNVKRVKEANDVEPGIVQEKELPLPDSTNEEVTVVNGGSESSRMLLFEEYLEMSERMYCGKPLCVREKHDSAEKKMESATEPDESSDEEASEIKRCVDRSISPTKALRPCIPKSIHSNANTSDNIPDNCGSDDPFEFQCSKLSLRFRVSFAMLTSDLRQEQMLDLWGPKEIVLFELGMFKHGKEFHEIQRNIPTKTVQEIVDMYYFWKKTNRYKLWKANRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D170</accession>
    <name>A0A061D170_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0108590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766747.1">
        <property type="nucleotide sequence ID" value="XM_012911293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D170"/>
    <dbReference type="GeneID" id="24563102"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108590"/>
    <dbReference type="OMA" id="MGEFWTE"/>
    <dbReference type="OrthoDB" id="363998at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="19837" checksum="C216AC71AF18FACE" modified="2014-09-03" version="1">MQDAREFDALCRDIYAYYSNQLVTVPGERLAMMLRATGEVWTKAELDRHTSAHGQYFSFDDFHKIARRKRDAALAATGVEGVPHVLVDDYGYVINLTVAECQEIVDAFKALLELRCAAGDELRGPVISIDYFRHLLTSVGDVIPKQLMQQLLSDGLAFRSEMSLRTLIKLLNRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D181</accession>
    <name>A0A061D181_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766757.1">
        <property type="nucleotide sequence ID" value="XM_012911303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D181"/>
    <dbReference type="GeneID" id="24563112"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108690"/>
    <dbReference type="OrthoDB" id="366203at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="600" mass="67606" checksum="B01A5FBB40EFF557" modified="2014-09-03" version="1">MYQGPFTTTIDEPALEIAVINKPIKDGFMAKTAVSMTEFLRLYCSIPLAIVALIAMKRYIGSIVSRFVLTRRNIEEGRYFWVKNTDVFDQHAQRKYSYYEGSDTDQVVSDVKAYQAYKTDGFWTNRSCYLLSTQLCNTYVLNIPCYSDVRFTTQMFPAVNRRFCVLTAEIKEVDLYETDMPLEGEYSPVSHTDYDILNETTASLELNVPDVVDVYPWDGPTPNTASSAVQPANPSVVKKRASPQKYQNVSPYGGLDGETPLWVQLDYIMRIDPRFWNKVIAAVDARHITYFITYNLVKNTARFSQDVIFNGVSKMRTVVQSRVNQLRADDSDSIGIFHRNMRQPLIGEAYAALKVFDGSPVGSEGSGTTSLHTDRNTRSSRDGLLRADNYFSLVCMLLGLSFTTLATLENTNSKWILAQNIILGIAIAYATLSTLAFVVDTAAIFWFEQDTDVPYSNVQVVVKDANAKVVDVIPADCRKPIDVALVTINNEQVTLMRSHEAYRTPTIAVSLEHVEYSSWYVPYITIAYLSNAADADAINQSQANRRFLKAHLLSRFSPRIAHSLARCVLPSTLCPMVLRKIVNHVADNPQYQCFCFYVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1B0</accession>
    <name>A0A061D1B0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766782.1">
        <property type="nucleotide sequence ID" value="XM_012911328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1B0"/>
    <dbReference type="GeneID" id="24563137"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108940"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="227" mass="25952" checksum="5130347A74E3E52B" modified="2014-09-03" version="1">MYNCGYTEILSELRNFVEALIHAVFHKHCIYPQESFVATKRFGITVKYHQKQPVIRYVQEIATLFHQLLRDKVLIALSIVVTNKVTKDTVATYHLQIEPVLYAPKLTHCDSNGLKNELAKALMRLELQTCPPENEHRALRGGHRLLHQTKIDRLAQRSIGAIVKELRRPESTPAAAYTATRPLLRLSDNDSIFSLPRHYISSIFVTTESRRQLGSVKLPVVQLFKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1H2</accession>
    <name>A0A061D1H2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766674.1">
        <property type="nucleotide sequence ID" value="XM_012911220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1H2"/>
    <dbReference type="GeneID" id="24563029"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107860"/>
    <dbReference type="OMA" id="VECCANS"/>
    <dbReference type="OrthoDB" id="364747at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="660" mass="75293" checksum="3840CB4CB75E50D8" modified="2014-09-03" version="1">MDVDGAENVGVIGLEGFIINNVQEEEANGRSPISDCLPVVRPKINWRRRPMRHARLRAQIYNFGTNGMTQYRDGEVKKRFDSICENLGIVDKEDLYTLFLKRLDTRKKLESSHKNLEILVEALHYIQSMSCKKTVSARDAINKLRKRSGTLNLRRFVKYVSKLCAEAKIEWLPVVPNANIVRQMLDDLILALRQSDKSEDILSNVKEINISPEVARLFQDPCLSGLDECLDIPCNKGEEDAMSHGSDSPHQRPTHDEDVVKFPKARRSRMAALIEEKYDLVSDTTLRLVEWTEKCGLKPNFNVLNARSRTKLHCRKTFLASALHVALLMERIQVHQKFLLNTWNVVRTSFYKNCSSIFMLVVQRIRNKYGVLVNSKFLTLTFLKHMLRNMDSPDTKTRVEPMQYDFRENYATTEKVSHDDLPTVFGDDGKNDKMSSNCSPEIRFLNNVMGAANPVDDTLWKFDPLSDQRGKTTSTPKNGAMHNTYEDAACYLTNMLGESDAGNGFPAKVPSEIGEVFDEKPWIEVPTYDDKRGDAQRLSCGQIRSLTLKLGYALGFVNKDEHRQPSMDPGLDAKLFEILTYYLDAFSMDRIGPLRKQPVNSYTSKQRSVVTWKQGKRKKYKSFAHVCYGPDLAHTMATTFKRGMAVALIVEEERKSGKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1I8</accession>
    <name>A0A061D1I8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766847.1">
        <property type="nucleotide sequence ID" value="XM_012911393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1I8"/>
    <dbReference type="GeneID" id="24563202"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109590"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="92" mass="10410" checksum="2317BFD760E19BCE" modified="2014-09-03" version="1">MASIVAAVLECDREDEHSDQCKENKNSRNTEYESGKHYCKLQLDGECLGRECSTFYYTTGRCRAKCQYCGTLCGQHVFFLQCTIGGPSLESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1J5</accession>
    <name>A0A061D1J5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766178.1">
        <property type="nucleotide sequence ID" value="XM_012910724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1J5"/>
    <dbReference type="STRING" id="5866.A0A061D1J5"/>
    <dbReference type="GeneID" id="24562533"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103140"/>
    <dbReference type="OMA" id="FQCFYKH"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CPL" evidence="3">
        <location>
            <begin position="611"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="800" mass="88038" checksum="092049CE40BD2FF3" modified="2014-09-03" version="1">MKLNVQTQADASQKRRSARLTHGSKDAKAQKNVKSARSKPSRAAAIKAAMRIKAEATQRSTRLVKSTKMVAKKTVKAAVSKPAADRAAGSKAAKPAAAAKGKGSAKSSSAVESSKGSKKDEKAVKSTTSKTTKAAHAKTVASKTTKTAPKGVSKTVKKDLDKTAKTSKATSQKTVAKESAVKKVKEEKKSAVASVKTEKGAKDKPVKKVTFKLDKSAKKAKPSGKVYKKETKAPASLTVNGKSAAKSTSAKGKATKSTAANNAKAAKSSKAPKGEAAASAAKSSRKVKKETKASKEEEKKGLNKLYSRLLVDHAKPDVVKSTTAQILKQTGSSKYPVMANKRHISRILQACLKYGDTQVRSAIFENVKKNFTLASLNAHSARFFVKLYHYCNTVAKDFLRKSFFNDHNKSLLFSRYGSDVMDVMYQKLKNKEQLAVLRLYALSNFFVLDKDAMRKVEATGSINQFISIIDESESRESCVETLKTSVIKMIDKAQLTAALSHDLLYIYWKLTDNKEQLIGQLYKVFGQLLSTRNGNTIMCDLFGYADKKMRKSMLKGLRTDFPEAVYNQINVSFLIKAILCTDDTKLSIDCLLRPFQDELQKLVSHQYGHLFVKAVLETPKEVESKTSMKDPAVRQAELQAFLLPLLVELFGSIELKEVIENKYASQVLMSTLRLSGDAEIMQSIVDAVRADCELSLMENIDTFRFIQTLVKKPSVPMEVLCPYGALWPAVKPNVNRILSRKSVFLLVDILEAAMRNADQQVIADIRETIPVSKLEETCKILEKRNEKHAGLDVLIKLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1P3</accession>
    <name>A0A061D1P3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0108660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Found in a nuclear export complex with RanGTP, exportin and pre-miRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766754.1">
        <property type="nucleotide sequence ID" value="XM_012911300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1P3"/>
    <dbReference type="STRING" id="5866.A0A061D1P3"/>
    <dbReference type="GeneID" id="24563109"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108660"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000369">
        <property type="entry name" value="GTP-binding nuclear protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="211" mass="24194" checksum="209D52052696BBCA" modified="2014-09-03" version="1">MAEEMPQFKLLLVGDGGVGKTTLVKRHLTGEFEKKYIPTLGVEVHPLKFRTNCGGIQFNAWDTAGQEKYGGLRDGYYIKGECAIIMFDVTSRITYRNVPNWHRDIVRVCDNIPMVLCGNKADVKERQVKAGHIQFHRKRNLQYYDLSARSNFNFERPFLWLARRLLNQPQLVFVGECAKEPEFKIDPELAEQCERNLEAAANVAIDDDGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Q9</accession>
    <name>A0A061D1Q9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766912.1">
        <property type="nucleotide sequence ID" value="XM_012911458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Q9"/>
    <dbReference type="GeneID" id="24563267"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110240"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7024" checksum="B07DE63481686AF3" modified="2014-09-03" version="1">MLKDIKRENAQPLYAVQGVTLSVEAHETQRGLCLINRPSRSHNSTATTDNSSNMRQQHDVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D221</accession>
    <name>A0A061D221_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766353.1">
        <property type="nucleotide sequence ID" value="XM_012910899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D221"/>
    <dbReference type="GeneID" id="24562708"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104760"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="7633" checksum="4681C853523301CA" modified="2014-09-03" version="1">MVVDRRAIRSGELAYQAFYDVAATKLTGLGRGDCAASSTKSVVGQPSSRAVTQCFVFEIHKSLLLRVNGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D240</accession>
    <name>A0A061D240_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0111040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766992.1">
        <property type="nucleotide sequence ID" value="XM_012911538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D240"/>
    <dbReference type="GeneID" id="24563347"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111040"/>
    <dbReference type="OMA" id="MNEVERQ"/>
    <dbReference type="OrthoDB" id="360190at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="378" mass="42130" checksum="D692D220990504C9" modified="2014-09-03" version="1">MSLNTLVGHHLLGAAVTHTLLPETGYAATRLGRKIRFSIVALIISALLWRELPDDSETLYGMVGLPTNATQYNIVTQHSKIKAEMQDNASMENADKIKEAFQILMNEEKRRGYDRFGDVQSSLFADADLHVVATVLSLAFHALSCIMCIAFFSSNQFALSRYFMFLYSAIAFALEMECRFVKNSSFFKNIYYVNELLPFQQVALMRRIAPSVALLLNLVCAYFFVDMDKFHLFLWHSAVSTNRAIIEKMTDVVDATNYVRTLPSHSTAGLRTPTSPAQKVMWHFTAQVPHDAIVDTPQAGGSDEEGKSEGGKSSGSSSKSANAVKEILDSMNEVERQKIAELLKITSSNRRPANNWYSVMQSSAVLVGIFLVVKYCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2P9</accession>
    <name>A0A061D2P9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767064.1">
        <property type="nucleotide sequence ID" value="XM_012911610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563419"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200350"/>
    <dbReference type="OMA" id="HEPCQHL"/>
    <dbReference type="OrthoDB" id="361818at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="897"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1714"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2343"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2366"/>
            <end position="2385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2693" mass="293776" checksum="DC49C10A2458CE85" modified="2014-09-03" version="1">MTSLFKQLEALSVKPNKAYSRFRRSYASKEHYTRVLVCESWEFMLGLDATIVECEVLFRSCLSDPSQAAVAAMAARSAASSAESTDSADVEMTDVATGPSWQDKEIEFMLESEFLECERTLQLFLDLCTPWLLHEPCQHLIDFLIYQFELASRFGEMLLLSLLPIHESAYFVKVAEMLTLPDGSELSYYIPPKAPAAKNADNGSSEVQNTRVGVSRDTILEGTVRSFSNYRRISETVERLALVRQRAGTYLPLYTVLSVAFVEQNRGKLGDSEIRLLLNNVFSGLKRPDVSAYYSAQLCTLTVLFCTVTVTISVQRTVVTCMLNPLLSELRDSDAPPFDLRMKLKDSVLVLLGMLHQQKERLDALPVNTTQLLLTVLHKYPAMVNVFRGIGGSGEALDFSRLCKVLTLSVVKACKPSARAAQGAESANDLDLIKWMVEFFMHLDYSILYVRVMLYTLIDDLVVFALSTCRQSEALFQWDPVTMTGSLNTHHCDTLSVYGRFFRQLHASSSAVFDDVLQRTLQSTNRSPEVLSVFLLICHSVSGGCPLHFSVLVHKCLGKESPTGPAALPKSVAADNLGSTLILYTDPNLPSKSRSQLYGMLSAIMNADLLSTVDHGALCEFVRVSVSDPQCIPLLYRDSRLLSLLPSSAVIRVLISQIGCLLTGSGLSFSAPASLKAKSKSHIPAMEPFYSKCFEVLNRDSPASRQLLFALSLFADFYGRATIDEQECMQQASHHFMRLLHVISRSAKHAKSSKKTSKSSEVSESGATEHSEDANSTSGSADAGPNDHGSDASDSTAIAAPSLKTICDNYFRSSDSGEHRSYCSTMSLLFGVLDSMMQLSTATTYVNTSSGEDTSATGANPISFGNDTVWFNEWLVCYGLYESSELLSAVLKQSASSTGNSKADNHADEVGEPGVTSKGNKASHPDITLSAEELRQLFSLSEVVLCYAIKLYRGSVLLGELTYFFAQCHFKVLTLCSISAPRFADVNGGSNPAECNDLPDAVFDRDALLLHAMLTLSSEEFTSHFKEALSTAPKSVQSRVHLWLKYYFEFGHLVRSVEHRPGLRLDLYGGIMDSQVEVNRSKMTVAFRGVIGDVLALGPAMVSEILNGKADLLWPSRELSEPLEDDCGIMQIPYASLSELDGIMKMYGRCMDMLSHLVCESLRVKAFNNSCLMIDVLVNSLAFLVDKEHLVRRPAVLMISRAMQCYVDTPGKSPARFVAACGYSVCPEFSTAIAALEYPFKGFDKTLRKLCSGLLENNAPFPNVMFVNQLFSHCASEPMVLSLLFYGCIFSGTSLQFNVDVLRRIGANLSSDHGADVFCTALAGLLPFVRDYKISSPSDVSVLHRFLLCFATSASSVAAFGLHGKAGCFATTLCPAVLDTLTTLVHGMSDMGESLQADIDVIRKVCSYCAGACMSTLSEGAFWSVKGEVQSRLLESFDRAFGSMEAATRLLCLRYLSSCYNKSKNGVKSVVSIIPRLQSCSNHFQELFVMGIVDNSPADMLPEVFNAVLQQEKSSKGWFHVSFLLLQRYLTRADLKSDSAVSLVCKGTASLLDGIVKAHKAGAVPTSAGSAAESSLSELGHVAVFINQLYLRLQQASGSLDVKSMQKLHADVCRCLRALCKFYGAATFDFVRPFLSKMCIIDYTLSSSSGDEANKGDNSTDADSQPAKTPAPAKSATKSCAAICHLLMQVFESDRSSSATLGFAELCTAFPAGPKHSSSATYNQGAGGKSRGATRDSLVPDMSFAYDEWLSYAIYSCICICRLDSSSPAVTRCVELLKSSGDPVGVLSTLVLTAVSASAEEEPRFPSWVSRLDVRGIIMGKHLDSSSKLGLAYDMQSFVHQIVVQSADLFEVAIDALSFNDRKSPEHRRYLSVSLLLQSLSISMVCFKNVGSDEALAAMNKKKKGLMGVCAPSTTASENTDLSSTSILKKSGEIIRLVYAANPEENYPRLALGALSFFWCKDLVSSPSDNFWSAACGIDFMKQPWVCDYVAVALASISKSIGHKFGLSTKPPMSSAAAAFSKELSIVLAKLAKVLSDFLSATDACILVKKQDDALQLLVGRSRKSAWRTLIGLCYGLSGEWVLHSFALARSRVELLLQLKAFNHYVVLDFVNAVKLCIRLVACGEAEEESFDIQLVQGLSCSLAKLTAQLVERHLSNVSLSACVLGLMLLLRRRFGKATGDELLEAIMNLLVFFSSPSPVEERFSLPAEEELLTDRKLASVCSDMFEDLLQCNSDKVSKAIVAASDKIILGKATPVRMATLLSFYASVSCKYYDILRLVLGLDFTQVLSAMRDGSRLLSLVSISLHYNRIKSRYVSDLDRLYFLNVNLLSEFEAASASVSNRKARKSGKSSAPAESDVTAGGESAASDSIATASGENDPNSNDPTPASGLMSAYLEDATGSPRLDLSCRLFSEPKLEFGSEKGVKSFEDCAIVFALQYFSKIRSSDLVEVLAKHIGYKSDTSAEGAASPLPRDGTRLLLRMIVAALGEYGSLGATQFVLPRVYQHLNTVLESTVEELCAPVSKPSKSKSSKSRANSGSSWKVFVNGVLALRAIRACVETWDSKQASVPDMCLNVWLPTLGKALGVFDFLSGAWEIQEWERALEGTFLHLLFACSGDADRIEQVLSGDLVSRSEVCKCRVLNILLSLWGKANFHLGGSVVNIMPVLGELADDESEEVQRLSEQLNERIQSFLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2S7</accession>
    <name>A0A061D2S7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767094.1">
        <property type="nucleotide sequence ID" value="XM_012911640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2S7"/>
    <dbReference type="GeneID" id="24563449"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200650"/>
    <dbReference type="OrthoDB" id="366012at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="770" mass="83778" checksum="D2B619D258577077" modified="2014-09-03" version="1">MWHPSTSRGHGLYVVQLFNDLTFAHRRGVRLASVLCGRRFAFNIRSPVPSQSVSGTLNRVISRRKDVFTSSVHCDVDVCASENLPRHLQVLIKTTSAGPASQYRQECRRFSSTATKEYAAAGAADDLGYGNGGQNGAGNVTKESPSTVNAEGTTAAAIGSPAAPEQSAPESCRGKTAQHVDDTQSGVSSMVNKSGAAPKTRKASAKSSAVDAAPSSGKRAKSKATKQAATADAELKCESAVDNGAIEPSVAEAQALALDAAFELSDGESLDWNNKQLCKVSHRNFLLYAYNQLDMATVVKITNQVLAAYQTLPRRRKASQRRQYVQRFLRCIRKHKPLEDHRQLARWLLRCIDLLTCDDLYSMLRVRHILNYDNSFETFRASFGMENFESFSNVRTSKVQQDKLIGEKALKSRTAQRNLLMRHLKINKFRFLKDQNVTKAVYEANIDWVDAGVSAASLEPERFAFVYNLPFIEHGELTAALHEVLTRFSKVRRIDIFSDRLPPLTTLVKRSAVARNSAPPPRDKRMADALQFIANALVEQPVPASADPASTEHLVKQPSTEPTSAEGLGAMIGSTVVMGDDTVTGATVGARGGTEGIEAEHEAGSSSANAAAATTVPSQCRITPSSKRKHGASGQSPVVTADAHGAVAAGEWPACSQPALDNHVDSSMLEKLQNKSATSDSMDPQWVVLRFSDFKHAYFARLRLLQKFADEPRSLVSFDTKRSIFHNGKYLDLPLFQYSPRTENDPSVARISQGVVEDNVGLGAVGVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3B5</accession>
    <name>A0A061D3B5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766763.1">
        <property type="nucleotide sequence ID" value="XM_012911309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3B5"/>
    <dbReference type="STRING" id="5866.A0A061D3B5"/>
    <dbReference type="GeneID" id="24563118"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108750"/>
    <dbReference type="OMA" id="RWPIYAT"/>
    <dbReference type="OrthoDB" id="360746at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="85886" checksum="54C642001B2567A8" modified="2014-09-03" version="1">MGAPPRRWPIYATKRMAEVLPQLCAVGDRHTLVANVVFHFVGSSNVPSERMSRYFKHGYLQALNYVYSDRSFKEPPLALSTVQHAREIIFSPLNRRLVREVSPAMRPQPLEDLAGNIEAALYRWEDFIGGITCGSRFAMYNTRAKESVCANGLFRAVGAREFPRTVTLLRLNHKLLSTLEAITVNEYFVDAFAAATEVAQLEAVDMALMLLQQQDRPDLYAPFVAGSWRAADVLQKVVESESKTALEHFFASAPQSTIAQACDMLRSTDVKTGMGAFQHMTNGCRNLITRRSTDAAAITGAAVPSANHLELGDDEDISDFGDYTNTPHMVDTVADLIHMLKALKRYAQQHAGARDGLVSVHIERDAAAFCTARSAFIVDLLVGDPLYQSTLFQLLAWLWSNSGLLKVGHNLLPKVAKLASQFDSPFTAYVNMVDLRNKRSSSGTSVGDEAVTRFRETGDSATPHFNVSAGISRTLKGLLQEYSIAVPQFDRHWGAEQRPICPSRARYMEQLATGILSIERQLREEGWMPTDFCDLSSYDNGRACLRGTRAAHRKCTAVSSCVKKRGRFLDSHNEETAHTHPFTTSMDIKPKSTAQPSEQLRPRLANWHSSSSASTRVTTSSSRESGGKRVNGFAPCVELPSGGQRRRCNAYAGPALPYSESGASLSRNHTPRCGQTIVRKDAPRGHHDLFLWDDESGLIIKYPMYEEQQNSRRSPYTCPWSLVPVYPENKKDDDDVQTDTRVLNWSLQVVEQYLKAAIEIAKSENGNERKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3C1</accession>
    <name>A0A061D3C1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD40 repeat myosin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0108800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766768.1">
        <property type="nucleotide sequence ID" value="XM_012911314.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D3C1"/>
    <dbReference type="GeneID" id="24563123"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108800"/>
    <dbReference type="OMA" id="GIIECVY"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="70"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="1396"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="921"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="163"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1665" mass="186810" checksum="CF34FC70D5F2F537" modified="2014-09-03" version="1">MAEIASSMAVGTHLFVSSETEVWQEAVVDSISDGKVFVRVKGAEPGELVELKGGNKYHPHTEDRFNTPSGYPDDLCNLTYLHEASVLHALDCRFSVDDIYTLTGKILIAVNPFKTIKGLYDDETIVRYLELRDHGVPHVFGVARDAYNNMTKNEQSQTILISGESGAGKTESTKFAMKFLAIAGAESMEKKSPAEVKVLESNPLLESFGNASTVRNANSSRFGKFIELQYRKESPIKARLVGARIETYLLEKVRICQQQDGERNYHIFHQLTAAATRGDKYSFAHPESSGAQSGTPWEFDLAAFRGSFRIVPADSERDFDLPTFDETLAALRTVGFSQEQVRVVFDIVATVLHLSNIEFVEKGSEGAMISNMEAGHCQTVTTLLNVDSVSLMNALMTRTIKTANEMYTKPLRVDEACDVRDAIAKNVYSMLFDHLVERVNESIGYVPDANLTTGILDIFGFECFKHNSFEQLCINFTNETLQNFFNNFVFRCEEELYSAEGISWNALDFPDNSDCVDLFKSRPYGLFAMIDEECNLPGGRDQSLCNKVVQRHSNNARFAKVKLDQSSFVVNHFAGAVQYKIDGFLEKNKDQLSNDAVSFILSTKIDEMRSIFQSYIDKKASTVRAGGRAGGVTKQKTICTQFSGQLDSLMTKIGATNPHFIRCIKPSPECRPNHFDRKTVDSQLRCSGMLQVVQVSRAGYPVRFPHAELFHSFRYLLEAKEAESALNIEDKRKQGEFVLDILVTRYMTSKPPEEGSLAIGKTLIFMKNGPYEQVCLAMQSLRNSRAIVIQARVRRNIQRRRYLEALWSIRTFQIWVRYKIKKLQRQRAIRTQAILLIQSMYRMYVQRKLMRELRDKVSRLQSLWRSVNSRVQTEEKRIHTMATKLQAAWKGYKCRCYYLELRSATIKAQLRWRSICARRTLRSLRMEAKDLGNVIKRAQALEEDLKKEKAMRADAEARVLQLTAKLSTIEKSLEELKGRVESLTKERDGLAERLHEAETNTQKAQTDLRMIKEFVSKEAVSSSQSDWLSNVLGGQGGDKAPGDSSAAAAAPRTGSIKSDKPSGRSIRSPPGTRTRSIEQTADIVLCGPPGCGKTRLLEMALIKKGDDKNLELLRSADEARSRKRRVAPAVFDFAVNPGHPISVTEIPGSYFDSDEARTILRNAHLVAICFDPGNQQTYEDARVIVKMLKQLVDCKNTRICLVQNDYIILESARPIVCDINQVQTFAVENELLYMRIRDLMEFVEQVTAYVEGKRGQRAAGANDGSKSGRTPNRGALSLFYEKFRNFWAGVNYSGFQNKLLVPTLVAQEGYKLPPLSLKRVAAIYNYTAAVTCLAFRPEDPSDPYIVLAVGRRDGTINLYHCFRTETELLALNSANFDESEPHPVNDNVMITESFTLAIHTKAVTCMCFSKVEVNELVTTSVDCTIRAWNVMTGQLIKVFNDSDPGLAVMFHPVDPTLFICCNANPTMRIIHYNQGTVLQKIRTKSELRCLVFDDTRFNCIAGNERGAICIYEAQADLHLKLSTTKSISRGPVTCVNFVPSPSPDVPPCIIANVCSGQITILNCLYEGSSGKISEITYRYTVNNAHVALPVRSCYSRFGGGWCISGSEDRNLLIFSLLEENMPYTVSFHQGPVVAVAVNRLDTLLVTSDSKGSVAFWRRVLVSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3N1</accession>
    <name>A0A061D3N1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0109800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766868.1">
        <property type="nucleotide sequence ID" value="XM_012911414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3N1"/>
    <dbReference type="STRING" id="5866.A0A061D3N1"/>
    <dbReference type="GeneID" id="24563223"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109800"/>
    <dbReference type="OMA" id="HDEAMLG"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="300"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="599" mass="67694" checksum="63A12D8F08452B31" modified="2014-09-03" version="1">MAELDEFQKRVIMWVQGAVKCSDGSVRQYSRNSRIHGDVVGSAYGNVALMVGGAKTGKTSTYLLALADLVNVERYGSDETGPQRDEYRNKTILNRSLKPCRSPAKPDVPKIRGLPKFDWDSLMVPLAIVLVPSREIGSKIFETCCQMNLRARLFAGGLGYKKQSSFTAGHAATGRKKQSDNVDLIVSTPEMLLRVIHGVFEDARIDIRYLRFLVMEEADILCEGFYLEQLNEVLNMIHSTELRTLCVTATKTDALMNHILHAHLDGDADGLARVTIAHPGSHTVAKNVQQVFTAIAQSDPLDRLIETLEELDIRARRDGRQTVVYCNTVKCCKFLEHALRERGYNAASLHGEMGYEQRSKSVKEFGTQSNILVATNVASRGALSCHVDHVISFDFPRNVTDYLHRTAGVAHNGTVNTFFAKKHLPVLKNIQRLNTPEHRIEYRNVSARVARVLQLQLEWDAKLALRNRKLKKGGRKALKLPPRRNILSPVNKKAMKRFYLREKAVKKVQFLQKRGMLRKGYGLPRWPDRAVEASDSQEFVRMQRSADGFLQVIPKRRSRVPRVSQEGAYDDDAVPIEGAPSYEQETSDKPRKHHRNIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3P6</accession>
    <name>A0A061D3P6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K+ channel tetramerisation domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767502.1">
        <property type="nucleotide sequence ID" value="XM_012912048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3P6"/>
    <dbReference type="STRING" id="5866.A0A061D3P6"/>
    <dbReference type="GeneID" id="24563857"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204740"/>
    <dbReference type="OMA" id="FYPRSQY"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="288" mass="31223" checksum="A644286AE40084D0" modified="2014-09-03" version="1">MVHSVKKQCSDGAYGQFDAPASYGTAAESAELPPIPASGLSEVVNLNVGGVSYVTTYRTLLNHKGSRFATYFRQLFAHLYQNAPASSLGDDFSYLANDRSTPYPTVFIDRDGRRFSYVLDYLRDGSVALPDDQTVCRGLLTDAQYFRLSGLEVTIAHTLQLSLGGTRTPSMSHSQDHASAAVGRAPCDRASLVTHDAARTLSPYHTASCSHRMYSVGSAASTSGIAYTCDESQSAFCSQQSYDEDLASSQKSFLQVGENDNIEDAGMFVQTTPLSRLGKTEFSTNFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Q7</accession>
    <name>A0A061D3Q7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-galactose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0110000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766888.1">
        <property type="nucleotide sequence ID" value="XM_012911434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Q7"/>
    <dbReference type="STRING" id="5866.A0A061D3Q7"/>
    <dbReference type="GeneID" id="24563243"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110000"/>
    <dbReference type="OMA" id="CGAIGQV"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="392" mass="44075" checksum="BFC4AACF27B43FBC" modified="2014-09-03" version="1">MVSRGNASHEDDGHYDAGDAQLDSNTARYRGSEKKGKMRIVIEDGATKADVRRKMVKDAGMAVMLFGLVCACYITYSYLQELMMRIPLMGDKKFDYPVFLAFTCFTTNLVTTSVLMGSMQLRLNWRRRKMGDSADGPKSVFEDFDKKVACLGMLAATSNVMSMLSALASIKYVGIPTQIVIKSAKMIPVLIGGFLIFGRRYPVYDYIAVFVITLCVFGFNYFKPKGRMDGENTLVGMLMCFFSLFCDGLTGPLEDKMLATKDLHPFMLLFSLNFFGFPMATAAVFVFEGTTPFKLLMQNPQIWMYLALLSLTASIGQVFIVICLKLYGSLYTTLITTIRKVASSLISIFMFNHYMSVMQWISMSGTFATLFIRQFFKYKMNTKNRSSNGDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Z3</accession>
    <name>A0A061D3Z3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0206040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767632.1">
        <property type="nucleotide sequence ID" value="XM_012912178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Z3"/>
    <dbReference type="STRING" id="5866.A0A061D3Z3"/>
    <dbReference type="GeneID" id="24563987"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206040"/>
    <dbReference type="OMA" id="IRQFCFG"/>
    <dbReference type="OrthoDB" id="277458at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="316" mass="35418" checksum="F65ACF4DC9E150A5" modified="2014-09-03" version="1">MANKGEQDDQKEEHLTIVRISGIVDSGDVTAAGKLSLQNAGIASSDDLFSMKSLESLSLAGNKLTDFEFLSQNHNLKVLDLSRNRIQKMPNMANFTNLTLLNLANNEIADMTPVTCLRNLKVLILNNNKIKVMCNLSKMENLETIILSHNEIADVKMPSKTMLKLKKITLSHNAIREFPITSKLPNLQELRLNSNKILALPQNIGMMASLKLLDVGNNRIVDMKPIINLNNLQNLNVFGNPEPQLKLEDIKQHLQFLKVFNSTNLCPDGGVERKLKRARRAAETPKRHREYSESSKQGASYKGSKNPRNTNGNIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D485</accession>
    <name>A0A061D485_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767043.1">
        <property type="nucleotide sequence ID" value="XM_012911589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D485"/>
    <dbReference type="GeneID" id="24563398"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200140"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1207" mass="135635" checksum="35BC210CAB2D7BFE" modified="2014-09-03" version="1">MEINELIGKRGGVGSAITSETFTGAFGNIEKELNQIAELVSDTRQSSFGGLGPNRHSLKEFLKRLKDGLDNKRLGDAEKGLGAITKATGNVQSNKFGPKSREIEKAVKDIKAHVEELRKKLLNERGKDIIYTLTDIKSVGLGYGEAFWTTVKGQNIGGLGSIQKHLQEQNEELPKQTKLIDAAIDDIRYELFQVGIRLNHKNETDDVIDQLDWLRRKIGIRDAKHGNLLKIQNEIRRLQSETFTEKPDAVDKAKTAIESELKRLRGVLEGERDNDVIVTLRDLRDVGLSENKWNKHKNTKGLKQIEEELKSQQESLTKQPEQINSGVNLITKQLDELRTALQSRNGNPKDDVINSLEDFLSFGLNGSNWQNGKPGLGQIKQDIQGQNAKLSQASDRIEQATDRVLRETEDMLRKVQNNLGPELVPYDTITSYLRQLKEKIGKENGNGEGLQGIQREISRMQGDAFKSNPEKIGQAEREIANGLRKLQSELDGHVTNPLRDVIQQGLGGGDKWNGHNAKSFDHIESNLERQQRVLTDQPEIISSGMKEITDELQSLRTELQGTDSDDPENRGVIKNLEFMTKQIGNNDDEGLKKIKREMESLKNDQGKGITDSLDKMSLAIQKAGAHAGWNLGQLEDPHIDGKLKDIQDGLTNLRLTDLAEAIKLCDNFLRDADEIEKNTIAALLTHVDDEVEDAIKDLTKVARTLYVDSVREALELFAKKVDEDLEQLPNEIDRDRYMGYKGFMKYLQGPLSSDLTGDEQSVAELSSAFQEVFEQMEKYVKGELTRLHDEQNRERNPSLPPTEDPYTPKLKDVYDALTALLAYLRDNDDGADKLTELVERLTKALGDFVPSDFKHPCTPLLDTVSRGLSKFACEFNNTYISAYSGQRCREEHAHKYAKVLLSLIPTTYTALTKLATKCESEWKSFHICELTADDRDNPLGNYLTRCGYRVCSSGSEQDAELNHMFTGGGIYELLTTPIEGVAIEMMIDGEPLNNGINLIHIISLLYNTLCHYFQVCHIYVSPEPRYPCTVRDMLSWLSGLQYTQVADKLPGHCKALLNRRCHDGDTPNRDDPIMAKCIGELPLTIARTCSNSTALLTVIQGNGHGFDLAAYPYSVDFSNNRARLHYHVDPVALLDMLREIACRLCRVLYFLYSQCCRSTARVKGWRECTYGRQVQSHHWQCNTLGRGFTNTTTTTTSTTTTSSTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4B2</accession>
    <name>A0A061D4B2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0200440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767073.1">
        <property type="nucleotide sequence ID" value="XM_012911619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4B2"/>
    <dbReference type="STRING" id="5866.A0A061D4B2"/>
    <dbReference type="GeneID" id="24563428"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200440"/>
    <dbReference type="OMA" id="VKPVFWD"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="132" mass="15407" checksum="9CCE69AB85447B2B" modified="2014-09-03" version="1">MPVLQRQVHTGCVRYAPKQKGKKGAADTQRVTAASTDSAGDEHLFNIYAGIPEDHVMLPDEAYPSWLWQLDKPDKTYGELLQMFVYGKGIEDAQMRDYNRFRRLHNRHLIKLNNIRLQKARKFQIKGHLWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4B7</accession>
    <name>A0A061D4B7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767078.1">
        <property type="nucleotide sequence ID" value="XM_012911624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4B7"/>
    <dbReference type="GeneID" id="24563433"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200490"/>
    <dbReference type="OrthoDB" id="367001at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="232" mass="26086" checksum="960F163E8EEA3EBE" modified="2014-09-03" version="1">MKLEAITASVEEYVKELGTWMDDAKTYIQDVKKYVDDIMEQLDGKHRQAIDQAAADIDSELGKKVGELNEWIEKAEAAVSVAKQKADDVFKRLDKDSGTKIRQGFEKISEANKKISEVNTQLGIVHKDLGDWKGVAKSVLRNSVQKVGEVSDKLDPGKRGAEHPIGENLNQIDTSNEDIKKANEQLKTQLEKLSKWITEADGLRQKAQEKAEDVYRSLAVHQQLSDKIKEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4R1</accession>
    <name>A0A061D4R1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0208500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767882.1">
        <property type="nucleotide sequence ID" value="XM_012912428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4R1"/>
    <dbReference type="STRING" id="5866.A0A061D4R1"/>
    <dbReference type="GeneID" id="24564237"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208500"/>
    <dbReference type="OMA" id="CKDHPKK"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00677">
        <property type="entry name" value="S15_NS1_EPRS_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="300" mass="34287" checksum="F81DA80692268301" modified="2014-09-03" version="1">MFALRSLVRGLSYAQAPRACHCSAPPQSRHVSHVKAFRIKGYPFEKVRAPKTEWYKRAEAAFLAERARVPHGLVGRWQPEDLSGLDPRISQALSLKCANGREIRRARTLILMKHLQKEPFDTGSAPVQLACVSEKILNLRAHLIRHPRDNCRKRAMAILLSRRHKLMKRLYNEDFQLYQHVCKVLKLKCVLFSVPDSRNRAKAINTIGVDGDICKFLIRQKLWWGRFRPRPIALPSGKKIAYTRHPIEPPPADFNKPKVHKDQLSPAWPYGVSPQRIAGKYIIYNPTAPGAGYCPVPILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4S2</accession>
    <name>A0A061D4S2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767754.1">
        <property type="nucleotide sequence ID" value="XM_012912300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4S2"/>
    <dbReference type="GeneID" id="24564109"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207250"/>
    <dbReference type="OMA" id="GISWMIC"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="199" mass="22587" checksum="0E3C75AF11844AAB" modified="2014-09-03" version="1">MAPDSDTLDSWDAYTDSEDEQQPEPPAPEDVAKLSEKLRALRIGISWMICSQCPVRVEAAGAKTRRPTFSRRTRSMLSEAQHAVPTDPLAHVSLKCLKDCDNVAKKLSQKIEQSQAKSAVWLQFIDTLFQACEKKIELKDLQTLKRKIEAAIKAKEAKQSQVTFSKKKPNDISSVKNYQDELDMLYGDLSDEDEPFYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5B7</accession>
    <name>A0A061D5B7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyadenylate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0210390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768072.1">
        <property type="nucleotide sequence ID" value="XM_012912618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5B7"/>
    <dbReference type="STRING" id="5866.A0A061D5B7"/>
    <dbReference type="GeneID" id="24564427"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210390"/>
    <dbReference type="OMA" id="YIGCLHH"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="108"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="215" mass="24542" checksum="7335F9B845483960" modified="2014-09-03" version="1">MLNVAIDKYHVYIGCIHNSIGDEQLLTLVKCFSDHVRCCKVMRKLSTETHLGYGFVQYEDPAYADEAIAKMQNLVVKGIPLYIRAAYPFTSTTINDRDEEEAKDIKNATVYVSELTATATDNDLRAYAEPFGDVEHVTVIPNRRFGFVTFSRREYALGFICHMDGWQVEDTIIACSWAYQSRTATLPGQFESSENEKQDAIFGQRYSYDLMPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5U1</accession>
    <name>A0A061D5U1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768272.1">
        <property type="nucleotide sequence ID" value="XM_012912818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5U1"/>
    <dbReference type="GeneID" id="24564627"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212280"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="74" mass="8191" checksum="BD299D7947F7BE14" modified="2014-09-03" version="1">MEQEDKEDDDENNYWSHNSGGSGSMEGSTGLGILGATTESYMSGKGGHIIMKDVLFLESDVYEPQPPRLLERPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6F2</accession>
    <name>A0A061D6F2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0300380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768319.1">
        <property type="nucleotide sequence ID" value="XM_012912865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6F2"/>
    <dbReference type="GeneID" id="24564674"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300380"/>
    <dbReference type="OMA" id="SQETYVF"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="406" mass="44471" checksum="E7301EE092569F5E" modified="2014-09-03" version="1">MRCMVSIICHVYLVLAAGWLCTFVYGVQWKVLNPDDKSVTRTASAFSATTLYTFGGEWQGTYSRDLRQFDFFKKTWTSVEVGGTAPARRAGATLTKLASALYLIGGHNENGTIGSIHKYDIITNKWHNVQISGDVNFIPRSGHAACTDGQNRIFVFGGYSDEGLFLNDLYEIHLSSKSNPESNAQQIDATFKLLSTDRTITCHTDLNAGALNPSPKEHASMEIVDGVLYLFGGYSYGGSCGDGMWTFDLKTSKWTALESEMSPPPMEGMSSITMGRSVLFFGGCDFSYNSSRCYNDLWRFDTTTNKWYIIPTADDKPAARAFASIAFLNGGLVLHGGSKMDVRAFGETYQLLDMPCKDPAHTCLGRGTCSLTSCVCSSGYEGHDCGITSAPEDAVKSDDVPFYTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6M3</accession>
    <name>A0A061D6M3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768394.1">
        <property type="nucleotide sequence ID" value="XM_012912940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6M3"/>
    <dbReference type="GeneID" id="24564749"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301130"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="10293" checksum="440DE597416D5E5B" modified="2014-09-03" version="1">MSRKVLRLYQDINKLCDEELGNTLVWILRSRLSNNRSEATRRNIPFPHPIHLFSDDSTTTSLNRTYVAGKFTHIAILSQMATLSQCRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6N3</accession>
    <name>A0A061D6N3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 zinc finger domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0302450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768527.1">
        <property type="nucleotide sequence ID" value="XM_012913073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6N3"/>
    <dbReference type="STRING" id="5866.A0A061D6N3"/>
    <dbReference type="GeneID" id="24564882"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302450"/>
    <dbReference type="OMA" id="YRIACHA"/>
    <dbReference type="OrthoDB" id="360633at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="28782" checksum="26907A4FD993A29A" modified="2014-09-03" version="1">MKRSRLLQKSYGCDSCGKSYSRSDHLKRHIRSHGRSRTQFVCGVDGCQRSYVNHEACLEHRAMHIRKLEDGHIYVKGFLVEKHIAEDVTSFVCPVQGCNKLYQSYGGISRHIARNHSGSLICGIDGCTRSFENKEPLEEHRKKHEQQSDPGICYIKGYAVKKIDKEDGTVLICPFEACSSSCHSTSGMTKHISRHISQSSLVDDIAKEPPAFLCPHEGCGRIFTKVGVCIRSHDNFLCDTISYRIACHAVNSTFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6P2</accession>
    <name>A0A061D6P2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide chain release factor 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0208410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767873.1">
        <property type="nucleotide sequence ID" value="XM_012912419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6P2"/>
    <dbReference type="STRING" id="5866.A0A061D6P2"/>
    <dbReference type="GeneID" id="24564228"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208410"/>
    <dbReference type="OMA" id="LNKKIAM"/>
    <dbReference type="OrthoDB" id="365940at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600097" evidence="5">
        <location>
            <begin position="28"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide chain release factor" evidence="7">
        <location>
            <begin position="92"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="208"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="338" mass="37784" checksum="E63175DBF762B16B" modified="2014-09-03" version="1">MRLLTSAVPLLQCVAVWSLLVLRTGCGSESLRQAPCAAFLGALGLFEAAIALIGPASALSRGFQTRSRHSILFVSRDGPFLHRRHAPLRAHNSSVAVEVRPGVGGTEASMWAQELAKTFKKFCLSRGCTVREELCGTTTVLRITGDDSKFRENGCSGLEERFLREAGIHQVKRVPTSEKSGRMHSSTATVAVLPTELTETQFDSILSQVVIDPRDIEWKTCRSSGAGGQNVNKVETAAALRHKPTGIRIECQEERTQSKNKEIALERLRLQLARERESDAREDAQSRRISQIKRAKRSERLKTYFFNTHQIINDRCGCKYNLNDFLRCRLDNVDCEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6R6</accession>
    <name>A0A061D6R6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat containing domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0109320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766820.1">
        <property type="nucleotide sequence ID" value="XM_012911366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6R6"/>
    <dbReference type="STRING" id="5866.A0A061D6R6"/>
    <dbReference type="GeneID" id="24563175"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109320"/>
    <dbReference type="OMA" id="EICCLEI"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="576"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1043" mass="119621" checksum="629D189CC04B5F39" modified="2014-09-03" version="1">MANVKQDNSASNGQHDVLSAKDKAAFKNMMDLYNQKLYKKGLKIAEELVNKYPKHGEAKSFKALFMSQIDPSKHEEILAIAREAIKNDLNSCHCWYVLGRIYKNKKQYKDTLKCFTMASKIDPQNERLLRDLYALAIEINDYEAFKKFASSGLQLRMKHYKEWMTFAFAQHLCGNVEGALKVLTEADRVFSGCYDAAPFELSSAILYWAMLLEDTAKYNECIKLLTDKEGLVLDKITRLEYVGRSALLGGLWDMAHNTYKQLVQLNPDNARYTLLFIITHRAVREAGIFQMPLPRHKSNVMDMLKPVQNELKSDSADVCNKAFVDKVKSGELPPILLSEEIMDIDGEYSTSNWCGENTVNRTFDHWVSAMRQKTESSASPTKDEQLFLGCYSYVDYTVKVAKALDMKALPKPKSVSIDEAESILEEYLKEYPIARCCIYSTRPKMNSWSRHPLFIFSRAITQSESRILLDALNEVKINNYLGKALTASFITNDHIRQFHDMLKPLVEVGCLSIFKFFVHGCTFEIVYHLLVLLEKYRKNLEDGLMLMDGIDKAQGETKGAITNNAQHNVASQNYLAVVLLVAAKIYDYAGFYDEALELLEQTLKTTPTAIDAHMLMGKVYRHMGALEKSKKAFCMASDIDRSDRQTSSKTAKAMLRTYDFVASRAKWRNFLVEDMTKEERDAQAKTNKYTPPEVKHMKYELMAANYHRMLYIQETTSGTTNEKNANSPEELLKNAHDIYAMVLEKQHEIYLHQLDFHSFCLNRLQYRTYYSFHKIRVAYATLVYFIRAAEGILWTTAEIKRTGLQHRTECEREIQQTTEDNSVNYCLDLIKTVSSQRVYNSGLYSAIERFASIVGMPKPHDIQLAKRAFRTCHRNPYHHHIYPAVFHMIVKSQYKDAAEALSQMLPVGGNLTFDRLQKAFKGTDGSVLTDTDAAYVYLEDVITHLQKMGVFDHRHSEAILRCVNECPDTMHRIMARMDHSYINSICTFGELESHYLEVKKLSVESRGCPHEKPLQDLVLSVERAAREKYPFSDLSASLNTTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D723</accession>
    <name>A0A061D723_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768494.1">
        <property type="nucleotide sequence ID" value="XM_012913040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D723"/>
    <dbReference type="GeneID" id="24564849"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302120"/>
    <dbReference type="OMA" id="CYYLLLY"/>
    <dbReference type="OrthoDB" id="360922at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="555" mass="63394" checksum="91AF768D4875B89C" modified="2014-09-03" version="1">MRVIITTMNDTHEFKYVYNYSIFNPICHNNVVDSARDATTFLERSLRELRDVLDAADNVTSGSEESIAKLSNIFSTFVCLIFPPHTPFVIYDEEQERSRLRLLTHELARTFLNVIHKLKDSSVAPSLGLCDSKFMVNVLNLYWRNNEEIACDIASSCKLVNSSFSHDLAELVKSLLESLQKECDHLHFILSSLKQGMKFESSRSVESDGVFAVRSEASPFNRNALFVDKETVISDILSYLETILHYIDKEEYNYVLSISLTTAEEDSCLLAALTNSYYLSSAIYDHILSQRTPLYKQESISDGYETQFQTCLFYRCKMQALRCILEAVKYNVVIGGDEYNFDRKMIMDDLRDVKFHEYADEWNSISGTCQIREITGITDVAIIREHLIKHDFDVSNAIMDLVNRPVTEAPSRPVNKTPMKPIVDANMSTYFVPKETRQAVLNYWDYVNRPAVYDDDYDDEADFEDLIPIKAKVIYDEIIDSSDDSSESAESDREPRNQSGTSSGQNAAATSEPKSRQAENRPRDAAPHRGRGSRGSNRRQNFNRKRNTINLDAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D744</accession>
    <name>A0A061D744_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768722.1">
        <property type="nucleotide sequence ID" value="XM_012913268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D744"/>
    <dbReference type="GeneID" id="24565077"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304390"/>
    <dbReference type="OMA" id="CLDSACM"/>
    <dbReference type="OrthoDB" id="439796at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="110" mass="12814" checksum="5FD02AC80BFB83DB" modified="2014-09-03" version="1">MGANNSSNRSRPQTHPFGVDLTRCLDSACMTLIMLLVSCAFLFMFGETLRMVERTTYAREEYVRRFLNRLFPFRLNFDFNLTHALLFCICMLLISFRYVQGTLCPDPVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7C2</accession>
    <name>A0A061D7C2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MYND finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0210250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768058.1">
        <property type="nucleotide sequence ID" value="XM_012912604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7C2"/>
    <dbReference type="STRING" id="5866.A0A061D7C2"/>
    <dbReference type="GeneID" id="24564413"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210250"/>
    <dbReference type="OMA" id="MMLQMDS"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="259" mass="29606" checksum="3D95BAC9ED558DCC" modified="2014-09-03" version="1">MDTLGAVVHKEFSYIHIPCDINSPVKVLRFQGTEDSFREEINKHFTRDSLLPEERQGFEKYLKEQLKDTQEKAGVDEKSKIDLTEDLLKTSIDAAGSTYQIIPLTLPTKKNGFIAINCYIDSIGRVKNLPTNARATKLCSTDIRGECFMSKTFDDEDIFKRVDMTMEEYGELFENPPDPTGRWDSSQALSNMLNPQSASALTALSPAKEEPMKHCENCKKEETKQEPLKICSRCKKVKYCSVECQKEDWRFHKRICNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7L7</accession>
    <name>A0A061D7L7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAB GDP dissociation inhibitor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768724.1">
        <property type="nucleotide sequence ID" value="XM_012913270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7L7"/>
    <dbReference type="STRING" id="5866.A0A061D7L7"/>
    <dbReference type="GeneID" id="24565079"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304410"/>
    <dbReference type="OMA" id="NAICRSQ"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="659" mass="72046" checksum="6A1574ED572FF6DD" modified="2014-09-03" version="1">MAELQVDAVITGTGLTAAVVAACLSHDGHKVLMIDRHVIYGQAMRTSTVKHLLEMPESRCLNRVDRLREQFEAMRAKIASEMAESARSEHVDGDQNAPGVSDDQHRQPISQKGSQADMRRLHVERLQETLNTMYANKESHPRVLFELAPFAQQGLNELEALDHLYSESNKYALDMWPKLMFARSAVVDLLLNSGAHNYIHFTDTKGPMLYGYEPAEEGGRITLHEIPNSRNAICRSQLLSPMEKRVLMQMLTNLAADHYLPQFSSMSLKASASKEESKSTLDTLTVDQPDSNWLQFLRDQGCTQNMIDMFSHGICLGGEDVVAWTKQDGIRRLLKYIQSIGVYGQSEAPFLYPMYGTGDVVQAFARVSAVLGATIMLGTGVASLEADAHNKLSAVTLTNGFKVRTKVLLIGDEVTAGDAAHFAPTAPGDSARSSRQARRLHVVTLILQQPLLAGLNMAVVLPRPAEADGGPQCRDPMYLLQTGFDADAAPANKYIIYLMTVDYHPPAEFNSFAECSHPTVSRLLRCCSAMASQSGFGLEATAMATYTSHELASDNGAAHYNVELHRGWLAEGCATERQAGNGIVVLPKPMGTPAVPLLEEIPAAVKVCDALVGRGERQLAPYDDAGLVGCLEVKRPEEPEDTHVESAAEKLQSIIDKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U2</accession>
    <name>A0A061D7U2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase, AAA family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0212040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768248.1">
        <property type="nucleotide sequence ID" value="XM_012912794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7U2"/>
    <dbReference type="STRING" id="5866.A0A061D7U2"/>
    <dbReference type="GeneID" id="24564603"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212040"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02656">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="6">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="148"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="380" mass="42606" checksum="1B99F33042F0BB84" modified="2014-09-03" version="1">MNDEERQQRAVELSQQAIDLDNAGNYRAAFDCYLRALDQWAVVCKYQKNPVLQERFCVRMKEYLERAEALKRMLNENAPVDEFSKAGDAGGGAGGPAFSEQVDQLSKIQRPNVKWSDIAGLEAAKESLQEAVVLPLRFPNLFTGALKPWRGILLYGPPGTGKTYLAQACATEIAATFLPVSSSDIMSKWQGESEKFVKSLFQTARERAPCVIFIDEIDSLCSTRSEGENESGRRVKTEFLVQMQGVSEGGNGVLVLAATNLPWSLDTAIIRRYVCSAVTLIRCSFDRRIYIPLPDFRARRTLVELGMRGCDHELRSEDFDEVARQTEGFSGSDLNVVVRDARMQPLRKCKDATHFKKVVRNSQTFYIPCSPGEWFATWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8A1</accession>
    <name>A0A061D8A1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">THO complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0306570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768939.1">
        <property type="nucleotide sequence ID" value="XM_012913485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8A1"/>
    <dbReference type="STRING" id="5866.A0A061D8A1"/>
    <dbReference type="GeneID" id="24565294"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306570"/>
    <dbReference type="OMA" id="DPCEIYF"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="362" mass="38903" checksum="9B5D1720EA2F595E" modified="2014-09-03" version="1">MATQLLNQRLFSGSSPKKTTADMPRSIKPQPIPSDALRLKSKVKDLCYNCSGSRLYVASRDGVTVLDTEGLTAHCALSVRCTRVLTHPKDPDLFALLLMEGGETPRAYVKVFSLPQNAGSEPVLKCTIWSGFEHPWYAGAWSSDGNTIALLDRGDHLQCADVSTFADCELPASSAISLTTEVYGLMYTSDALVLQKVDGRIDILSPDLTVRASEQAHSHIVMATAYNSSRDLLATGGSDHTVHLFSCADDYTCVGTFPGLEGKVSSLSFSNDGMLLAWGTKDTLYVSGDNPNQSDTSTTGDEYYMTVAGTDPCEIYIQVRMPVAVTHVQFSPCGYSVAYACDFDSMPKGSGSTGAVGIVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J3</accession>
    <name>A0A061D8J3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0301910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768473.1">
        <property type="nucleotide sequence ID" value="XM_012913019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J3"/>
    <dbReference type="STRING" id="5866.A0A061D8J3"/>
    <dbReference type="GeneID" id="24564828"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301910"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="198" mass="23734" checksum="932F4DD0D6102228" modified="2014-09-03" version="1">MQELWRKKQSDAMRTLLRIRTWEYRQLTAVHRVSRPTRPDKARRLGYKAKQGFVIYRVRIKRGDRKRNVQNGIVYGKPKHQGIRKQKSKRNLRSLAEERVGRRCGGLRVLNSYWVGQDAVHKFYEVILVDPFHNAIRNDPRMQYICKPVHKHREMRGLTSAGRKARGLRVKGPKAAKLRPSIRANWRRRQIQHLWRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D937</accession>
    <name>A0A061D937_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0303960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768678.1">
        <property type="nucleotide sequence ID" value="XM_012913224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D937"/>
    <dbReference type="STRING" id="5866.A0A061D937"/>
    <dbReference type="GeneID" id="24565033"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303960"/>
    <dbReference type="OMA" id="FNCRTIV"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="107"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="351" mass="40946" checksum="3BBCF896A6752FD3" modified="2014-09-03" version="1">MSCSVSRRVTKVLVSCGTLSAITLPVIWFCAYQWKYHVERMSYLPPVINLVLYVLLILEFLVMTLSNPGVLKKKHFPAQTYNHMTGTYRRVAPQRFLEIQINGQIITTKYCVTCHIYRPPRTVHCSSCGGCVLRYDHHCPYIGNCIGFNNYRRFYCFVMTCCLYFLAMLISSVYRFVGFFPRPWESFEKEAAVSIWTFVSIIWNVLVFWLVLGLCCFHILIILKGQSTYDRIKGNYMGFNPFYRGCKRSLVDMLFVRHRLMEFVNPWSPKHSAQYMFSPGAMFTSQEQCEEMRQQNEEFEDSATVPMLNTHEKNTLQYIKVFGNAEFTFLNQSSIDYDIVSDASVRTPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D967</accession>
    <name>A0A061D967_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0309910</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769274.1">
        <property type="nucleotide sequence ID" value="XM_012913820.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D967"/>
    <dbReference type="GeneID" id="24565629"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309910"/>
    <dbReference type="OMA" id="TWTQDFK"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="436"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="16">
        <location>
            <begin position="682"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1173"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1357"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1357"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1375"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1421"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1452"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1482"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1520"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1568"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR97088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1610" mass="180873" checksum="601DCA00AA38E864" modified="2014-09-03" version="1">MAPQQKTIEQRYQKKSQLEHILLRPDTYIGNTELQTQQMWVYNPETKRMVYEPVSFIPGLYKIFDEILVNAADVHARQQSDPSLHRMTFIKVNFNKETGAVTVANDGEPIPVQIHKEHNMYVPEMIFGELLTSDNYDDSEGRITGGRNGFGAKLTNIFSKTFEVTCGDSRRHKQFGMKWEENMKKIKSPAKVVPYHGKDFVKVTFVPDYERFGITAMDDGTLKVLLKRVYDVAGTTGLKVFWNDERLPISDFKHYVSLYFDEEAQLMKVYDKAYRWEVMVSATDGSGFQQVSFVNNITTLKGGTHVQHVLDPLVAAITNKVKSKNKDGVELKPYQIKNYIFLFVNCQIVNPTFDSQTKETLTTKPTRFGSRYTMNPKAVAQILKSTLLERIVSFAQHRLNIELKKKMKVTKAVNRLTGIPKLEDANRAGTRSARDCTLILTEGDSAKTSCLAGLSVVGRDNYGVFPLKGKLLNVRDASYKQLVQNAEIQNILKIMGLDISKKDQTTPEGLRYGSIMIMTDQDYDGSHIKGLLINLLHYFWPKMIQYRGFIREFVTPLIKATKGDAVVSFFTMQDYVHWVNSTNVSGWRIKYYKGLGTSTDKEFKEYFTNIRQHLIDFVYEDEADDDSIDMAFNKKRVDDRKAWMQSYEHGTTVDHTIKNLKYSDFINKELIQFSIYDTERSIPSVVDGWKPGQRKVLFGCLKRNLISECKVAQLTGYVAEHSAYHHGEASLQQTIINMAQDFVGSNNINVLEPCGQFGSRKEGGKDASAARYIFTKLMPITRLIFVEEDDNVLQYQNEEGQIIEPFYYIPTIPMVLVNGSEGIGTGFSSQIPNYNPYDIISNLRLYLSNRDMKPMVPWYRKFTGRIEPNDKGGFDCIGTYQWLGEEGLLEITELPIRRWTHDYKVFLESLEQGVGRRDPLILGFVDNSTHESVHFTVNVNADAMEEILNEGVEKVFKLRTSIATSNMTLFDGQKKLKRYSNELEIVRDFAAVRLETYEKRRLYMINNLQLTLKRISNQVRFIHMVINQELILFKKKKAVLIAELKELKFDPHSELVKSTAGSEVTPPVLPTEPATPAGQSRRTSTLDAQAADYNYLLNMPLWSLTLEQVQKLNEEHAQKEEQLRQLMVTTVTDMWLEDLDRLETAMRATYRQQETAAPTPSRAALLQLGKRKLKSTGNQKSGATPKVAESPAARTPASASNRANKRSKTKADSDDYSDYYDDVTLVSDTYTDDDVDMVEATPKPAKPAKTTRRQISIATAFSNANKAADNTPQTGQLACATPVATDRPAELPPNPMKAAMPEINAGTESFNPNHRQYAQHTDLDESDNASMTAESDDGFSLSQMEFSQDALAATDIERLMADARRKKQQREANRTKSLNAPQSAHTTPKGGAKTPASATNTPKRGARTPQRAGGTTPKGLKASSTSSPSPATAKSRSTPQRGGAKKLQYYESSEEEDYYGEDDEESGYEQEDEDEEYEETTTRSQSRSARRGGTAASQDTAGSRSRRNTAAAKADEAKSKPTTPAKTTPSAANHGEKASPSGAPGSGDKAGREVDIDFSLSQEPAENEGPRGDSSPSDKHTSALHRAGLAKFSVSLADRLRNLTPKPPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9H7</accession>
    <name>A0A061D9H7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0311010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769384.1">
        <property type="nucleotide sequence ID" value="XM_012913930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9H7"/>
    <dbReference type="STRING" id="5866.A0A061D9H7"/>
    <dbReference type="GeneID" id="24565739"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311010"/>
    <dbReference type="OMA" id="WKEYCAF"/>
    <dbReference type="OrthoDB" id="364906at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="791" mass="87453" checksum="3BD67A67AD3EB850" modified="2014-09-03" version="1">MAARVQHQLEDMVPELRRFSELQLFTESEVQDIVKCRRKYEYAVISTDPVYARNSFREYIRYEVELDRLLQERLRQAKSKEEKSDVRYNVPAEHGKVPIKVTVRRRIHRIFNRCLKRFGTEVELWKEYCAFCYRIKAFNVLNRAIMGALSKNPTCEALWKVATQYTMTLKGSVAARRVVKMALRANPRSLSLFTLLLELEVQVTQRLADYAKSGEDGSPGEVDPEEISTKTWSTIMRHALKSLKGSDIFKMLFFGATVCARVQRAPGFANALGDYGEFSSLVFNEMFNRRLPHPVLGLYVWQHRLLESLLVHRSEPSDACPPPETVFGEMVEDCASSPAMMPVVCRFINVVIASEDDTTPEAGATSGGADEPSWVMDVDGSQPDVTSTNKRSATESAPSESDDPEIDACCGGIDSVKDICFLRPTSDGFESSTQQCEYVRGMIDAKQLRALGALFRKHFAGVVSASASKLGPIALRSQGNDIAEALLSSDDDLLRLVALQVTQSTAKSHSVSGYSLAIEFSRHVDSACLAPFVAMVNRSILHSLRSTHIKESSKSGMLIRLIEWEHLSDAAKIEAARNVSVDLTRQQLLQGVTAAVKLAGSDAHLVEIVVHLLDLSAKVIIDDFTGSGDLVATVFNAVSKRIIDPVGHLRQYRTNNRSSRNAALLCVVISFWQVDCTMSSLKEKLGGNGFGGFTSKRSGASPAAYAKEAREVINLCDAAVMACDSVNVSDVGLKLGLRNRCWQLYVQCAKALEQLDFETMVLNLHSYNFSSDAVAARAYAQLGSAFVTNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L3</accession>
    <name>A0A061D9L3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0207690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767800.1">
        <property type="nucleotide sequence ID" value="XM_012912346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L3"/>
    <dbReference type="STRING" id="5866.A0A061D9L3"/>
    <dbReference type="GeneID" id="24564155"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207690"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="368" mass="41586" checksum="F21A1E86BD2B9A83" modified="2014-09-03" version="1">MGVIEKIREIEAEMARTQKNKATEYHLGQLKAKLAKYRTQLVEARAMGGGKGETFEVSKYGDARVCLIGFPSVGKSTLSNALTNMNSATAEYEFTTLTCVPGILVYKAAKIQLLDLPGILDGASEGRGRGRQVIAIANSCDLVLMILDATKDDSQKRKLERELENAGIRINRKPPNISFRQKKTGGLNINHLVPVTHLSERVVHSVLHEYKIFHADIIIREDATVDDLIDVVRGNVKYCKCIYVYNKVDMLSLPEIEEIAMRPNSVVVSSGKEWNLELLKERMWDELELMRIYTKNKGELPNFDEPIIMTPQRGDGRVSSAVEMIHKKMLDEFKFALVWGTSVKHNPQHVGLRHKLNDEDVIQVFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9M4</accession>
    <name>A0A061D9M4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768868.1">
        <property type="nucleotide sequence ID" value="XM_012913414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9M4"/>
    <dbReference type="GeneID" id="24565223"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305860"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600718" evidence="1">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="97" mass="10710" checksum="49C017B7C570A960" modified="2014-09-03" version="1">MKPSVGAVIRILLFAFLSIALHVQANKRSWSTEKARSHANYKPIGRGLPDISEEDKKAIADFKKLAKPAKTVNALGSNNMYYPWIPTVSDLNAAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q3</accession>
    <name>A0A061D9Q3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0208030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767835.1">
        <property type="nucleotide sequence ID" value="XM_012912381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q3"/>
    <dbReference type="GeneID" id="24564190"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208030"/>
    <dbReference type="OMA" id="RHISRYW"/>
    <dbReference type="OrthoDB" id="382094at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600721" evidence="2">
        <location>
            <begin position="19"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="667" mass="77044" checksum="116FEDF5B2355338" modified="2014-09-03" version="1">MPVAYYRLLLLLSRVVLLSHFYINDQWSATESHGGFCLGVSHVPRNTFRPRVSSVFSLNAVLYPSKVPKVPDVVARRLGVSRNLIDSRCVRSIYAFISAAGYGANAASAALPRRWHCAQSLDEEDNHRLLKEVALNKEEHLAKSLDPKCSFYRYFNITRSNVGEHLRKTMDEHFESEREQAARSLYVVDGNAFNGDYTNWRLPIPREMASYDFEGVNPKAGEPLSAQGDEVKPRFGDAMLDSIHTVISEADSADCVKGAEALCDLYDEVGDYEYYETCRGKVIKKDYLEDVDILITDETKREREMRHNVLSQPTAFPSYLDPVNPAHRTGRGRELQRRSDSGSCAVYLRHHYVGRLQRLRWNMDVDPADDILRGPRKTGNSVTKEFVDSIEWEQPMPTHHDRNFFKRSFAEGGFGEPDRTVDSYFDVQFIGSPDAYPYAISAGMQFTWPIYWVPLLAKKHPKRYCQPLRSPVFNLGGIEPLQLWFYPEGSASSTDGFCSLKLVSPPGWCLPYRIYLFVFSEYNRVVAGPMYRESAEYVARSLNFCRLLDKSDKERIRMRENDKDYVILGPAGNVYAGVGIVDEPVRSKDGAHRFAYDWDEGDYDFNQWLKKQTADPDDAFQQENVDRERTHSIWYESHKYKYVPDRHISRYWRSRYSKELDWRQPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA23</accession>
    <name>A0A061DA23_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Reactive oxygen species modulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0312760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769559.1">
        <property type="nucleotide sequence ID" value="XM_012914105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA23"/>
    <dbReference type="GeneID" id="24565914"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312760"/>
    <dbReference type="OMA" id="VKMGFKM"/>
    <dbReference type="OrthoDB" id="422939at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15200" checksum="75181F16C4AD745C" modified="2014-09-03" version="1">MWQYISGGSGTTIKPPVTSKYDEQVPPPPAGGPFAPPPNYDNTDYSGYTLSDTYGDSGSTGQGFLDRITSNPRARNCLASVKMGFKMGGAVGGIFGGITGLYTGLRHRNLMILPVSMIGGAVSFGFFLGAYKLLSYHDMQDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA70</accession>
    <name>A0A061DA70_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0109380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766826.1">
        <property type="nucleotide sequence ID" value="XM_012911372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA70"/>
    <dbReference type="STRING" id="5866.A0A061DA70"/>
    <dbReference type="GeneID" id="24563181"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109380"/>
    <dbReference type="OMA" id="FLCCCNV"/>
    <dbReference type="OrthoDB" id="5953235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF35">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595609" evidence="6">
        <location>
            <begin position="31"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="237" mass="25998" checksum="E129C5CD4C062091" modified="2014-09-03" version="1">MLSLGWVALRAAVKTVAFIAAVLLVCGADAIDTPCDGGHRCKNGATCIKVSRGGIEQNVCICKPQYTGWDCSVELDYCKTHCRSYRKNVNCQQALCNQGNCISRTEYPFYSCDCGAFYTGANCEVEYNPCSQPATNPCDHGVCTFVRGTNQVMCQCKPGWAPNPNQQVMKLSWNGADIFVAPPCSGKTRRGNPCMLCRAEAKAMWHFVFLLSLGILLWRLVSGVYVSIAYRNANTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA99</accession>
    <name>A0A061DA99_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0313750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769659.1">
        <property type="nucleotide sequence ID" value="XM_012914205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA99"/>
    <dbReference type="GeneID" id="24566014"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313750"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600197" evidence="3">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="24157" checksum="E445CD4A72D0F64C" modified="2014-09-03" version="1">MSGWLRGLGAAVVVLQLVEGSGSGSGSVAVEGTGSGSGSVAVEGSGSGSGSVAVEGTGSGSGSVAVEGTGSGSGSVAVGELRGLGGTGEDEWTVGLSIESAVGEEGIAIPMDVKSRAGFSSTSSHAASLPRVEQHSSGRELSASSPNSSSPAVIPYIIVPVTLVIVVICVMIYFRIRPFHRMISEVTTPSPPYSAIAAVIVAIIVAIIIFILIDGLWLMHRKHADDGACNKEFENGCKICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAC8</accession>
    <name>A0A061DAC8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769847.1">
        <property type="nucleotide sequence ID" value="XM_012914393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAC8"/>
    <dbReference type="GeneID" id="24566202"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401530"/>
    <dbReference type="OrthoDB" id="365950at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="265" mass="29465" checksum="1995E088ADA36011" modified="2014-09-03" version="1">MYGGIRRRAVKCCTAVLTLLYTVLAIIGIGGGIVLLPPLVRIQLPYEMPKALGTWHMKLDSAGNLITGSRFDFDITFYNPSLLPVAFTSQKAAFYFYPIGPTSECMKYHYKGEYVRASTGTGVISQLHREISKDTKDGLISIENLSVTIPPKRRHYDLYSTRVPVKAHFEVYRGNKGVLSALKPLYMDCVKYGAILLTLRIKEMTNRLWMLSKSVPVTYELLLPLRCEVQGSLAPLFSGPATFGVSMLQETTNYGERSDAAFGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAJ3</accession>
    <name>A0A061DAJ3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0110380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766926.1">
        <property type="nucleotide sequence ID" value="XM_012911472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAJ3"/>
    <dbReference type="STRING" id="5866.A0A061DAJ3"/>
    <dbReference type="GeneID" id="24563281"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110380"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="538" mass="57826" checksum="68DC2733D8016588" modified="2014-09-03" version="1">MFAQRFGPQALLRSGGRMFGPSDNAIVRNIEACTEIADMLKTSLGPNGMKKLIVNHINKRFVTSDCETILGGIEVEHPAAKVLAMAVQTMQNEFGDGTNSLIALAGEMLGNASLLLGEGLHISDIRLGYEIAYNRLLELIEDEVIWKVSNIRDEAELSLVVGTSIAGKHISRPQFITSLVARACASIIPPDPKCFDVDNVRVVKICGGSLDQSTVINGMAVVRDTSGTVKKVGRTKVLVVAGGLEFAGTEAKSTVMLHTAEELLNFSKGEEAEMEQVIRSIKDKGVSCVIAQGAVSDLALHYCNAMGIMVVKITSKFELRRLCRSLGATAVVKLEEPSEDDLGVVESAEVTELSSQKIIVFKAAEHRLSTIILKGATQGMLDEIERAIDDALCCISAAIRDPRFLPGGGAFEIEMARKLAKFAHTLSGLEQHAALKFAESFEVIPKVLAANSGHDATVVITELYAAHDAGDRFACVSSDIEHRLASAETGRVYDHYVVKLFCIKLAYEAVSTILSVDQLIMAKPAGGPKPRQPGPPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAJ7</accession>
    <name>A0A061DAJ7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spherical body protein 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0402070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769902.1">
        <property type="nucleotide sequence ID" value="XM_012914448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAJ7"/>
    <dbReference type="GeneID" id="24566257"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402070"/>
    <dbReference type="OMA" id="MNTHNGR"/>
    <dbReference type="OrthoDB" id="364333at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600201" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1128" mass="129335" checksum="8B2EB15EAF03FE33" modified="2014-09-03" version="1">MRSFLLLTLLAAASAVRAIVQRTGASLYHDVDSTYMPMFTEEQLRNPNIAPLDIASEKHLNEYVSRKFESNCGRVSRIVLHAPLDGLFKTIYYDAEPLNTPPAFLSYKAVVDYVDGAPTYIRLEGLVSRGVYGVRYFLKGDTAFTMVTRPDFIRSRVSNGTAYTLDLYADLDDFEEHNMVRANENSPQKIAIYYPKFNHYVEEVIAGTKKLWAYDPLSAEVCLKIMTYTYENKNFCVVRTMDWNGFIDEYLFVEGAGGYSRVSHNLKENFFIHGGSEAEGTQELDPNLITMVQVAPPTDEESDLFNSAKFIKANVREPPKRDEHWSSHTAYNASGNVETFGAAHEGYLIYRINDGQRVIWDRPGMGIKHFTHMVTLEGVELMQLTAIGDEGATYEYYMEKRKNGWAPITKSQMMELMNPSLVTSMFGEHVTIEAKDYTPEELEYINRCTTVTLDLKEIVYYAWYTDRVKIGNLITRKVLTAVDGYAFNRFVNGDEVVYNPKGKYLSTKVIHYKVKDMDLFGFDAIDKMTGKSEPHYFIKRNHLWLPVDEQSFNKTFLDMVVLTYYKQAQVADAIKEAEEAAARVDREIEEGAAKFIKDIDEAEASGTIGSLSDGAKPRRPIPKITRKPYDPYADPDEYMDLPLQQELDTHYGGHKLDRAANKEFLKKVRKHKFIRLELKGREDDRYKMHAIMGPDKTYRIVYNPAEGYLFDEVYESGVPVFATPGYIITEATIDQLPDGQHFLQIIAYDSEGNHVMLYFYKTNKYHNFKEISRATYTTLRFRSMVKTRIDVSKKNSHHRGVVKLVSKHYKKVSAFLPRYNCVIDEVRHRKYIIWRFDELNPEVVTRVVVFSRDNIQGVLLQLIDARANDVQRLYLNTNPKTDEYALFMHKGEMFALFKEYLMSRKTGIACFSSYRPNDIDWSKEIVEGSESYERIKAALTRSGRKWGKAPTLSPPTEDVEEEEPEADDELSGEPADEKAEKVEDDDSDSDDEEEEEEKKPADPDDEEDLTEEQKAAKEAAAAEAAKAAKLAAIQANLNRKADIKDSSYYVSIPFTLRKVVHKEGVVWDAGNTGSVCLDVRKYSKSQYRLVELEILTPDGRVEIRYFMNTHNGRGHYQEVELCRIGMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAL5</accession>
    <name>A0A061DAL5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769917.1">
        <property type="nucleotide sequence ID" value="XM_012914463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAL5"/>
    <dbReference type="STRING" id="5866.A0A061DAL5"/>
    <dbReference type="GeneID" id="24566272"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402210"/>
    <dbReference type="OMA" id="EPRDMFG"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="391"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="446" mass="50207" checksum="FD11793BA6370B3A" modified="2014-09-03" version="1">MDQDVLAHFDWSAYDNTAQSRFLEGREGVFWSNGFHNLVTLSVVCGLAWWAYRLWCSFYSLRCVQAKMQAMHKVLHLHGLAEYYDDLLMLTREHFNTIVKSHDYVVPLPVTRIRMPGHLIARSLRLQVGDGYDYKLPILPTPAAESAAASMCLDNLEVSFSMDCNRATFVSAHWGVPAADLHKICVDSTSAFREDPVTPFSVRRFLRRALFPNRQVQYESLLDTEGAAEPDSPDDTDHRYGRFTALDYTQKICSNEAVCYDAGSGIRCTVSPTIKTVEEDGEAKSIWDVLLSRQHAGRDIIPLVVVLYSPRTQDARVFSEGSVETYLGIAEITLITFRGTLKPTMFVLRGPNNPSGVVIDGVKQVCFSNDFGRPQEPRDMYGMGDEADKDCLICLCTRMDTVLMPCGHASFCYSCLQSLRTEKCPVCRAPFKSYVRFPLARTDSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAL9</accession>
    <name>A0A061DAL9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769784.1">
        <property type="nucleotide sequence ID" value="XM_012914330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566139"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400900"/>
    <dbReference type="OMA" id="CENCDIN"/>
    <dbReference type="OrthoDB" id="10692294at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600204" evidence="2">
        <location>
            <begin position="26"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1415" mass="152241" checksum="B1D57D79FF450704" modified="2014-09-03" version="1">MTTVVCVGIALTLSILNGPIGFTEAQFRGRTGYGGGADSISRTLSYDPTSYYGNSDATSAERETEMPVVLYPGTLRRYHESRKGKDLSESKDTRSTFGHSSSLPDYKASYGMKSSKRVTFDDSYNGTSNGYGNGGDYAYPNGIGSVHQPYIAPPTNFSTDEFNQNAGGVPSPAEAMVVNLPDAMLKQAQDTLHPNDYASSSTAFATQPATTQPVVVLPISNDSTGDTSKQNQAANTSLNIANPSGAALQYGQAGYIGNNVAYTGNAGAENRSELGLNFRGLKYDESGKPHFRLTVSCENCDINQDTGAPPNDEPVEDENTKGVHHSHHKHHHGGHHSHHHTHNDEKKDEDAASGEDASGKESTKDEPEKNDDTTSPDSEEPSETVEEKKSEAPPEKPPKAEKRKGNVFTKIVNHFKSKSKSKTDTETKPSDAEEETANEDGESSFIQMESSVKDPNAIKAVEDSTSINGEAADNAVKTTDATILGGVKGATMASVENPTGDVVADSNRMMVFAASQFLRDSVRFPSLFAREKDVTVADENPFAKLLRPFGDGTFYWFKSTKSVDSNDGCTIAGKVDSVLATESATNFRKSVSEEIVALPAPPSSEKDSHPTSEVDQKSTKQDPCKLTETGTDAEILTTSHSFLESSAEVEKKASKTNPVFSFFKKIGSTIRGWFKSSAPSGTEAVTDPDSNDVTPWFVEVQNGFRRLGRSIRKPFEKKTKTEKVSLLQTGAEVTGASERKNERQGLFTRIWGNIVDFFKPPRVTPPKRAEEVQDIPKFDAKSYFKAMEDLEKKAKKPNYSFLDTDSEAQYVVYDFGKEKDDTFYTNQDASKTDFVEAGSADSGYELTGVTYEPTDSDSAFVANRPYGTLEEALPSDSDQDTTLERSNEGDEYSSYNGLKGSTGEEQTHNITSPVYSKMCSNGAPNSVLQNSLESRGFKTRQNCVNGYLGRDCVKSKKTFDKCAPSAEDESLKKRKRRVFLNFIDKIVDNIENLLTTNSTPVSDEKTVDCSNESAAVDGPQDSTVSNDGNPIETSAETTAGTKVEELANFPDEADYEGTMKAMRLIGNVNDSVHSIVDGDTSKLLDGDRTNAENTLYYMPIRGNESSATSATEPSQAESEEALLSASDVNGDEPTEPELPRPEDTESIVSAGESPEYPIYTSDVESNSEKPSEISSESTSENGTPDPAVSPSDDGTVAKTDVDGTVGKVDVDGTVGKMDVGSHDGTLSEPAVNDAASKGTTGDATVDNVTNITDAPTSDATADVQVEPKSVDKVETIEITSQPATPTENKGITDETKSGDVATKSAADTGTVTANVTQSPMLVIVNANAGSGVVQKPSKLSVSEETEIPKLLRQLATDAVNQLKKSSDATPEDAETSSVSSALRGGSTLNMADMTDDERIQRRLKDYLRDFLKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAX9</accession>
    <name>A0A061DAX9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769894.1">
        <property type="nucleotide sequence ID" value="XM_012914440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAX9"/>
    <dbReference type="GeneID" id="24566249"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402000"/>
    <dbReference type="OrthoDB" id="10385355at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="319" mass="34944" checksum="64B73DCBA704BCEF" modified="2014-09-03" version="1">MVYTSLTEAPHNLKDGIDWLIALRGTDAEANLKAMGAAIHKLLADKPVGYTEVPGLEAVKQISKEFMEKPELKYHWCVERLLKRFNKPMGKAPSLLEKWFGIIAESDYANVVQNHGFDRQAMSDKLAQVVDSCDKFLNEMKDPDHYTSAYGSDATWAKSCAKDPEACAVILVGVAPMLYTGLRSLWDVSFFAAKKIPPFNSKRRLLDMLKAVGYGEPVCPAGIGASDVRKAFNLMEVDIFTTLYDLGGFWAFYGDKNAANSKSLRDVAPADSVEGEGRVGEEPEGEEPEGEEPEGEEPEGEASEGEASEGEESEGEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB68</accession>
    <name>A0A061DB68_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G10 protein family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0311250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769408.1">
        <property type="nucleotide sequence ID" value="XM_012913954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB68"/>
    <dbReference type="STRING" id="5866.A0A061DB68"/>
    <dbReference type="GeneID" id="24565763"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311250"/>
    <dbReference type="OMA" id="FGTSCIC"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="151" mass="17696" checksum="7CBDF0BDA6C6B30C" modified="2014-09-03" version="1">MPRIRTLNSRPPPEGWDMISDTLESLEERMKAAERESGEGKRRSEVQWPIFRIHHERSRYIYELFYKQKAISRELYDYCVREGYADAHLIAKWRKPGYEWLCCLRCIQTANQNFGTSCICRVPSRDLEPGKIIECIPCGCRGCASCDVKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH2</accession>
    <name>A0A061DBH2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0202520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767281.1">
        <property type="nucleotide sequence ID" value="XM_012911827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBH2"/>
    <dbReference type="STRING" id="5866.A0A061DBH2"/>
    <dbReference type="GeneID" id="24563636"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202520"/>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="337" mass="36400" checksum="603F48E81BA1415C" modified="2014-09-03" version="1">MVVKVGINGFGRIGRLVLRASLSYSALEVVAINDPFMTSDYMEYLLKYDSVHGTINEEVSVTADTLKIGSRTIKLYFEREPSKIPWGQNDVDVVAECTGVFTSSEKSQQHIEGGAKLVIISAPPSDSTPIFVYGVNHTKYDKSQRIVSNASCTTNCLAPLAKVVHDKFGIVEGLMTTVHATTANQLTVDGASRGGKDWRAGRCAGANIIPASTGAAKAVGKVIPDLNGKLTGMAFRVPTPDVSVVDLTCKLAKPATYDEIVAAVKAASEGELKGILGWTEDQLVSQDFVHDKRSSIFDVKAGIALNDTFVKLVSWYDNEWGFSNRLLDLALYICSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBL6</accession>
    <name>A0A061DBL6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769513.1">
        <property type="nucleotide sequence ID" value="XM_012914059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBL6"/>
    <dbReference type="GeneID" id="24565868"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312300"/>
    <dbReference type="OrthoDB" id="366441at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="420" mass="45886" checksum="D33A1A72ED8E9F69" modified="2014-09-03" version="1">MEHQTVLGVDSRSLSSVGGSRSNLRHVTAPFKPPVKESERPNTTVRSVNVTGAPATDPLVPSAHSYYSNVKEIPSALPPFVSFREADADTVQGDTNDLSVSSFSAAINDHISNRVGEVLKWKVMKPWEWSPLGDQAASYLQHYHSVTKGDAEAHASVVSKIYPSVFTFDDYGGGAHGKHASGVGEPVANVRMDSRRHMGAAIQKGELFDNLRHINNFFMADETRLPVYIAAFGSGFFSVLICLCAALYVKYLFARVRKSKSTTQQSDGGSALPLLDKRTIMAAQKKENLAETRAMNPNLARIDDYIRGEVKRWERRVLMAEAKAASPENFQEIMKELNSDAESSDSEEQEGGRVNKISPANAINASVDKLFQGNAQLEKALRHDSDSDEYTTDSSDSDASSSDDDYDSSSDDSSESDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBS5</accession>
    <name>A0A061DBS5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0313200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769603.1">
        <property type="nucleotide sequence ID" value="XM_012914149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBS5"/>
    <dbReference type="STRING" id="5866.A0A061DBS5"/>
    <dbReference type="GeneID" id="24565958"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313200"/>
    <dbReference type="OMA" id="LEPLPCK"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="585" mass="65996" checksum="A9CB4B1A2F02F735" modified="2014-09-03" version="1">MATADASETYDVDMDTAEQPGVAEGGEHAPEREKLDFAVLDYVNNTRFKHGIRSDEYGRYHAYCSKRLRILRRQGRTAPIKPNKYVKDEIDEENVDARSLEILTLTAERCWSHAMELKSRCESSQSAGPTERHHYVKRFERAFKTASRLEALCHKFGDTNSINNARVYRNFMEGNVHFEHGRFAEAYASLSSYANVMEQRKRSHQDDRVLQEAYASQLSNVNAAIKLCSFHMRAAGVTAAAKQPAREDDPNAELIAIVPDDSGNLAVYCRGSHVNVTSQFLLQQLLDAINATQKLVVTEDVLTRLVNAADVDAALKGELFDAFGTDALLSSYEEIMMPISEVIDAIHSEMMSSIDNQEPLRQVEGVVAYVKTLLEMEKCALVQVMTLHTMFHEHGKVDKNSGLPDCGEALRFTHMLKQHIATLMGDSKMGQIFLMPQEVTKTVNGLLLGMHKLATGEHNDGMALMNWANNRLQQQIEHPKKQQTLLIWRTLVCFQLLHNTARLCAARFYKRTVAIYARHTLQLADKEDDGEAPLDFAAVFGLEKRPLPAKPILLDLAYIHYQPPQMGKKTSFIGNVKSMFNSFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC30</accession>
    <name>A0A061DC30_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p29 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767481.1">
        <property type="nucleotide sequence ID" value="XM_012912027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC30"/>
    <dbReference type="GeneID" id="24563836"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204530"/>
    <dbReference type="OMA" id="GHGNIDW"/>
    <dbReference type="OrthoDB" id="448535at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="200" mass="23326" checksum="FB6EFD36BBEDE854" modified="2014-09-03" version="1">MQCCSRDTRLMDEEIDTQDVQVRTIGTVADRSRAQEIGQNVERQWVAVTTYQPVDTITKTVEIPVVKTVERVVPKPVIQERVIQVPREVTQVVEKVVEIPDVKFVEKIIEVPQVQYRNKLVPKVEVVEKIVEKPQIIEQWTERKVEVPQIKEVVRYKEIDETEEIIRYYPKGHGNIDWDKECEKAHIMIPNEVTESKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC77</accession>
    <name>A0A061DC77_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0205380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767566.1">
        <property type="nucleotide sequence ID" value="XM_012912112.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DC77"/>
    <dbReference type="GeneID" id="24563921"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205380"/>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="289"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="479"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1162"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1373"/>
            <end position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1927" mass="218598" checksum="C78FAC28B4C2C410" modified="2014-09-03" version="1">MLIIQKRPQSPYCARDPRCLYLLKHQVRNATSSNEGTNESDESIFRVYGNEARDTTIDGGDDLGTLEWCLRVCGSISEESDIPPLTLLGIILSLLQSANDDIIAATLAEKLGFSHLHFISRVIHFRKNLLQQWTLQLQFVAQGLIRNKTSTHMRTQLQSLLLKLTGNGMQHNLSNIDDMLSKIPPEELLTVLFTGSDTFKLTDTAPFIPKKVALDIDRDDNEIFERIVLPPIQNPIVANDEDLIAVDALPLWARGAFKGIAKFNTIQSMVFHTAFNTSHNMLLSAPTGMFIAVPLQRILGCGKTNVAMLCTLQNFGLFFTEGHKKGKVVYIAPMKALAAEITSKFSLALEPLGLAVREVTGDTEASLGSLVSTDVIVTTPEKFDVITRNSNSTGTQSDNSFLTKVSCVIIDEVHLLNDARGSVLEIVVARIFRLIESTQVTRRIVAISATLPNWHDVAEFLRVQPENAYYFGREYRHVPLEQIFYGVKDRDPSSVMLDICFEHMIQVVEKGKQCLVFVHSRKETVTTASKLIEKIQASLRAQTMFKPKKDVYRHFNSPLRKCKYESISKFAEYCISIHHAGMVRRDRDLVETMFKDGLIKVLVCTSTLAWGVNLPANCVIIKGTFIGGIGVDRHLNYLELTQIMGRAGRPQFDTSGTGVLITEQKNISNYVKMQTEQLPIESRLHRHLENALNAEIVLGTVLSDSDAVTWLRYTFLYVRMRKNALIYGLKSNKEEDVLLHMQRMVREAAGNLDKSKLIRYHESSGDFASTDLGRIACRYYVDFETIYNFAISLNPALHASSISHEDKSVHKVGVSHTRKQTYINEEYILERLCECKEFETLIYRNDELEELKELMDASIYKPRRGLNHITTKVSLLIEAHISRKTLRTSSLLSDMNYVIQNTGRLLLAYFEVSISEIVSGPPIGDVIYKWFLMFERQIWDIKCKQNSVVYHFCDPYHALYDKTKIQSSRLPTLSTLTASRLVKYDLDTLINLTHAELADSVKSKHEASTAQSYIRFIPYPQVNSSCQPITPRIAKVKVTLALKNCWSARWNGLSESFHVWICSEVRIINKASITLTADNQRDSVEMFIPLKEEDNYMTIKVFSCRWLGIVVENPFLTRRLQVADDGYTKLLDLLPLPTTVLKNNHFGYQYKYLNPLQTQIFPHCYFSDDNLLVGAPTGSGKTAIAEMSMFRLWRSQPQQKVVYIAPLKALAYERLKDWTIKFGKFKRVVEVTGDSHATASEIASSQIIITTPEKWDGISRHWKNRKYVRSVGLLVIDEIHLLGESRGAVLEAIVTRLSFISNFSATTTRLVCLSTALANTKEIADWLGVKPTKAFNFSPAVRPVACKLYINGFNIKAYCPRMNSMNKPAFSTILRHDLDAPVLVFVSSRRQTRTTAQDFLGLIQIKSVKWSRGNTLYEPFCDEHLNMFVEHGIGIHHAGLQDSDRTRIEDMFTRGQIKVLIATSTLAWGVNLPAKIVIIKGTEYYDGKTKKYADYSVTDIMQMVGRAGRKIHDKEAYAYIYTESRKVDFYKAFMFSPFPAESSFHERIVDSLNSEIASGTVASSEQALEYIRNTFFYRRLQKNSTYYLHMEFLSGCNEESSTDDMAQRVICLCLEHLLDIGCISINYNQSQALGKDNVLIPSVMGMLSSQYYICTQTVATFTVYLQQNAAGIGIFKMLRALANAKEFDEVPLRHNEDLYNMTLSSTAVMPIASADASNPHAKTFLLLQMRLFGLKAPIFDYNNDLKSVLDQLPRICQALIDIIACWRDFRLMQYTLLIYKHILSGANFLEQPLSFDGAADIIVKMVDVTSGRTLHGTVLCNLENWYQYDVSNAHELNVIISIRKLPSNNDVNYLTFGDERSNVLFGFKKLTSAGTHNFRYEAFLRRHSAQTETRLFARPSHYKGDPHFMRHPTLRPTTHPDTFNKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC88</accession>
    <name>A0A061DC88_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768760.1">
        <property type="nucleotide sequence ID" value="XM_012913306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC88"/>
    <dbReference type="STRING" id="5866.A0A061DC88"/>
    <dbReference type="GeneID" id="24565115"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304770"/>
    <dbReference type="OMA" id="KRSHRNC"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="347" mass="37792" checksum="67308F3E74EC210E" modified="2014-09-03" version="1">MVELLSSRQKRSHRNCVTSLGLDGGRLASGGKDSCVLLYDCSDEGLRNNGKFDVSPLASVRTNVLSVDLAGDRVLCGTSCGQVHLIDVRSGASGRILAHTSQVSCVKWLDSARNVAASTSLDGKAKVWDVRHTSVPLHELIGHTAGVNFCDSLPNAPPPDELAINFGDYYERVLTVGSDRTARLWNLNSGTHLAFKVPATLSQNVECGCVMLKRPQYIFAVGLDSEYVLVFSTKLKKHIGSISIGGPNVWVNCIRVFGPYLIVGTSIGKLYFVRYTFNGDHSSCTLEVESSFDYDGSVNDIRYGSVGGELRMYIALGTEMRLGRWSVCELESDSKPKNLINESIFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC91</accession>
    <name>A0A061DC91_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768765.1">
        <property type="nucleotide sequence ID" value="XM_012913311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC91"/>
    <dbReference type="GeneID" id="24565120"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304820"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="133" mass="14725" checksum="A1B6C99AD4B836CE" modified="2014-09-03" version="1">MSSWLRGLGGEDDGGEGCKKKTKECPDFKKCGCECCKQKCDEQADKCKPQAPPSRPGPQDSEASPDESFRVEAQIQEDDSPPFRPDPEAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCB0</accession>
    <name>A0A061DCB0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768795.1">
        <property type="nucleotide sequence ID" value="XM_012913341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCB0"/>
    <dbReference type="GeneID" id="24565150"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305120"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="8796" checksum="6BD70A7C20C1BF2B" modified="2014-09-03" version="1">MVGGPREIGCGGITLIGISKLAMKITRADAIRITGTISWKGCRRVMQRVVIARQYGGLRDYTNAIGCGGEKSVTITFTKPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCD1</accession>
    <name>A0A061DCD1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769913.1">
        <property type="nucleotide sequence ID" value="XM_012914459.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCD1"/>
    <dbReference type="GeneID" id="24566268"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402170"/>
    <dbReference type="OrthoDB" id="365479at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1738" mass="191217" checksum="AE2D815E36CE5728" modified="2014-09-03" version="1">MELAVLAELQKQLNEVILRWFRVPSPGDKTRCLQNLVDVCQQLADALSKLPSSTEEVRKIVRHNLLRAAQFTVLPVQSVGRSDLEQRHYQQQGPLLAKLLLLVTRNPSDDTKAHRDVMFCGIVAVWRVLFAQSDSNVHSSPEAFRRHSLVVDDLLEVSIALVGQVKNHESAVHVYMVLLEILTYSSAPQHKAAVLNALANAPGEGVLARVYPGLVSRIVRVLPRVRESDFRRAITVLEVWIRAALACNCGGIRCSAAKDSIKETWVLKTSEVVTLILDRYHAAHTQKLGYLCAACMSRNCVPSAFLTRLVAHVCAMLGTEDLWADARRIMTDATLPAKLALCRTVDGHLRNNPESDQALITYQGYAYLEMHVPDMEPLDEYVVLGMLYAAATPPKEDESAHLERQRLLALCDAPPDFAHFTEPREEVFSRVAAQYISRMPPSLQVQNVSEIVECFVGGVESGAQAAQLLTLLRGLLSHGPAALREVACDVVDVVVLTVVEPGCSSPKICLSALALLCVLFSRYRLTVPRHQVCDILFWLLPWCVSDSGPISQYARSLLLHIGVHHRLVSGELGQGNEVLRPPTSDTLMPSEKGAVLQNLLRFYKTLLVTRCVRELKQSQFCGTSMAHSVSDVLFVMLHYRLLGVKDVFDLALHLDRSWRLPELDLHANAALGVLGLDANSELTALYCYAFIAHYVNGQYEVLDNVESDVIEHFRERFHLGTLNGKAVSDLPAEVPGLSGNGSERGHSHLLPHDQQYVGSPLAGDEHITVESNERTDRTRIHVRKIREADQCPGSQLLDDTTPRNDQKHIGGHLRPESRPIRHSSLLDDIIAPPAQLGGLKRFQHSPLIEVIGEQPQTHVKRATQPASALRGDVDERMLRDLLRWHDMPLITPTQDGSPKRQRSVSGAPEQATITTNDRFSSRKLGYNSGETPSSTATTALSEAQDTERNEVLAGAEAADELPAIEATAADACDQLADNSSKDVAEVGCEGSSPELDFKDHRLAVVTLIATRCRYHLSSASSETRYVALFALHRCFCAFSRNVPVLRVRLYECWDALMDCLERSMRNLRSMSLVLGIMTIGTRHAYTFVERWMVDVFAKIADLVVSEAADNCVTSADETHGSIRFKFTTKLLEFVEEVSSRVVNRSLFGNLLLIALLMCKSTAPAVERATASVLRHLFQKNPSDVTKVLMHTGSCAADSAAVLRSVLERDVRRLLPQRSRVQALLPHGELVPVAPAGGFGVLRSLLWRGGSPIALEGCSAPRLILSQLEARGIPVQLSRANRVKSLAPSVCRAVNELYQSNSFFASRVAGHEVSPDGRRLTVKCTEQGVPVANFRFFVRDPDHGAEVDVGHMHLVMSSSSSMPRGKFRQEPNGALQRLLFGRSGTLVRLDPALFNSVKDAGLWSNLEYAIWRAPDGALYMHCYCDGPGVTRRVDYTMANLLSGGGAQLRAGVTDLDLFGTGIQGHLGAEIALAEWYTMSKKHKLSASLTYDSVRKAVWMDRAGDTAGLTVAAHCRARDLMRLLRLRKSAEGDGAPKAAVSATLYSSAGPGRYRVGVVGDAKTLELRGNTQSTGSDLFGRSACTQQAMSVKVPLETFSKRECSWRDKVYLRCQHRATAPVGSYDVTMGVRYGSEMRHSGFRGKPPGGRHYLMVAGEVTRRWFPQQPWTIIRPGMFLDVLYALGGGDTAKSPGVFAFSAGVIVKVLGLGVSLAITELPRNMPGGLKDVLTALKQSFYTHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCG0</accession>
    <name>A0A061DCG0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0402600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769958.1">
        <property type="nucleotide sequence ID" value="XM_012914504.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCG0"/>
    <dbReference type="GeneID" id="24566313"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402600"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="822"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="880"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="883"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1352" mass="145603" checksum="1C90CEC691E024CF" modified="2014-09-03" version="1">MANYGVKAKSTQCRGRTRGSGPLGTDIPHENDHLQVTEDVSATHDAGRLRSSSQAFLATTSDAASAESGRSCDSLEKGRATAEDLSGANLEAPTVDSEFDVKLLQSTPEECSTDGTTNCEIYGPSYPTCDTVKLRLTSCGRGDDVSPDGDIADVEAEPDARDSATVADSFSVSSDTIENVDIDCSEFGDMGSAESYMNDSAAASSYTSDADDPANKDASDDDNADVDIECSDIEEDYGAAFGVRTGGVRRGINCADSSDSLDCSLGYSDDFSDYCETSTPASVTRVGKGGGSQVSDVSKGDGSQVSDVSKGGGSQVSDVSKGGGSQVSDVSKGGGSQVSEASKASDVGASKVRKGDGSPLSAVNSGASKPAVRAKVERRAVRGAVDANGKIRSIDSNESVKAAYNTVELLSDAASAASGIESPSSAKVDQGDTSTISTPPARASRAAVTSRSTAKASSGSKEQFTPPNPLSANSFWRPSLPPNLDVSTPSNRKGGGTPRSQGAGVRSTNDSRKTQSTSNLRQMTIDSFKIKKPEQQAPVVETPVAAAASAPISNKGDDVTIDSIKPTSNEQQAPVVETPVAAAASAPISNKGDDMTVDNFNAATREQQTHVVDTPVAAAVPAPISNKGDDMTVDSIKPTSNEQQAPVVDTPVAAAASAPSSNKGDDMTVDNFNAATREQQTHVVDTPVAAAASAPSSNKGDDMIVDNVNATRTEQKAPVVETPVAVTVSAPSSNKGDDMIVDNVNATRTEQKAPVVETPVAVTVSAPGNSRGDDMTSDSASSLTSQLVKEDVEHYVGGVEKYCMWNLNPTTGEHEFDPGPLALDFYCNACQCALPLGTFRIRCVECVDFDLCIPCACKGAEKNEHKNTHKYIPIAPNSFAIFGDWNADAELLLLEGISKFGFGNWNQVAEMVNRRCTKNKSATECENHYNEFYIHSPFSPFPDVRRMRSPVKSQEAFQRLNSFFNLVQKAHSKEKPRAYRPSGNVDENVHHVDLIPRAVNMRATVGPRLKFFQNMNGYNVYRDELEMEHNNDAESLIKDLEFEPWDTPPEIDFKLRLVEIYNSMLDDRICHKRILIHRFWHDYPAREEAFKSMNQIEKAAYWRLSPLMRLHSEEDHIKLTRLIVARIEIEKRLRLVSTWFSLGLRTFSDVQNFDMQKFPSAHAAYRNAELQPIARNLLSSGSIKETALDDFSAQLCDRICTDLCITRDQVNDVLSAVNRLNGGMPMVREPSTSVVPTWDYCFDNGKLVDRNVQRIAAPHIALDELPDPSWHPRLVLEGNGPYALPPVDFTNISFSPLSSSAVQQSQVLPGIKSCFYIAKLLPQLKARVRKNVCKRKRSLLATEPIKRGNTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ1</accession>
    <name>A0A061DCJ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MYOSIN LIGHT CHAIN KINASE domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768930.1">
        <property type="nucleotide sequence ID" value="XM_012913476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ1"/>
    <dbReference type="STRING" id="5866.A0A061DCJ1"/>
    <dbReference type="GeneID" id="24565285"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306480"/>
    <dbReference type="OMA" id="RDKCHKI"/>
    <dbReference type="OrthoDB" id="365607at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="631" mass="69571" checksum="21EDCA11162F755D" modified="2014-09-03" version="1">MAQSNQGPAIVVIQNGMASKKSWKEWYGSSWIRYMAFASVAMCMYLPDQVTTVASKHLTVALNIPSANTGVYCTKLYATKTLVNFIGSLITVGVQMLFTKHITTISCISMVLMGITRIALVVSFFLPNAAVGFYITFIVHSFVRGSFESTFYPLGADDMSTISLSFKGSKVALWAIQVLMDVIIAEQATWMIASHLVIMLLITLLATVVWIVHCKFKDAQSEESNAVEEKEETEQAEHKAQPVAESGQPGKGADGGASEPAVSTKPAETPKPLSTTKPAETPKPLGNVKPAETPKPVAADTSSGTSAELNGASVSQDASPSEPKSSDAKTEEKKDEKDATGEKAPSAFKAFLMRLVGMRPVKPKEHQRCQNGCCNLSEKLVVKRDLTMWQVIRRVISPFFMCVCGWPLKNFFIPGLLPYTLVDRSLCHPINIVRMFFTFIVTFVIHFMKVNIESMGKPWGRAPRGWHMAWLFFIPTVACMPFIYIALHYPQGVIFQRLHDNPLNVGILSVMMSGSTTIIDTMGYIGISACSKNDQGERGNNSVRFIAINSFVMQLIASFTYRMSAGYQIIRRKYVDDVTNSAPTDDMSWIAGLWFWISSTLSQSGYDFVHEFDGNIREFVNDSSQVAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCK5</accession>
    <name>A0A061DCK5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0207800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767811.1">
        <property type="nucleotide sequence ID" value="XM_012912357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCK5"/>
    <dbReference type="STRING" id="5866.A0A061DCK5"/>
    <dbReference type="GeneID" id="24564166"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207800"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="588" mass="65519" checksum="2D4A03D3124427C1" modified="2014-09-03" version="1">MSRQSFGSSSGFVRIGSASALPEHLIPENIHGNLSATLPQGASMDERAVMSLSQNVYFSKCSVQINEYGIKVPALWRNAGVAVLTHHALLYEPNTVLNTTGAVCCKSGEKTGRSPADKRTVMDDVSKGNVWWGKVNIELSELAYAINRERAIDYINLQQRVYITDAYAGWDPEHRIRVRVISTRAYHALFMKNLLIEPTAEELAAFEPDFVLYNAGAFPCNRYTRGVSSSTSICLSYKRMEMVILGSEYAGEMKKGIFTLMMYLMPLKGLLPLHSSCNVGPNNDVTLFFGLSGTGKTTLSADPARRLIGDDEHVWTDRGVFNIEGGCYAKCKDLCREKEPEIFDAIRFGAVVENVVYDAVSHEIDYTDCSITENTRCAYPLSHIPNVMMPARIDEHPSNIIFLTCDAFGVIPPVSKLTIEQAMYHFVSGYTSKMIGTEMGISRPTATFSACYAEPFLAMHPMVYAKLLEQKLQKHSTDIWLLNTGWIQGPVDSKKGRRIPLKYTRAIVDGIHNGTLKNAMYEQMPIFGLMVPVEVEGVPADVLNQRLGWGSDEYDENVEELAQKFAENFKQYQSEANESILRGGPVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL6</accession>
    <name>A0A061DCL6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770043.1">
        <property type="nucleotide sequence ID" value="XM_012914589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCL6"/>
    <dbReference type="GeneID" id="24566398"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403450"/>
    <dbReference type="OrthoDB" id="360655at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1110" mass="121250" checksum="0330FA5BB4506611" modified="2014-09-03" version="1">MHVSGDDRGAARSPLDRPQTGHLHGAVRDIVLEFVSATDQCTVEALCKHLGVDRPDGVFRPSPGDQASASSAALEALLVTRELDALPDGDPWPALRHRIHALTSAAAALDKHLAEVTQSRHRDLMEACVRATQAEAMRNICESYVPRLRESFDAYSRSSLRNAASLSRTASHLAKVRRCHAMLLQVRGVGLYRDIVSCHGACIRHRILAAAVAVDTIDRLRTSNPETARLVLLRSSTDYFTSRLQSLVRNCAWKVESGLDFHSSLRLFHLLGLDTETAAARVLAGHRRQIFGIALITMQRYLNSDAASPEPWAGRGAEAGFTSPGGATAPSCSVSHLAHCARKLGPNMILLMVCKVLGEFTTFFESAAASLDHQSAQDGAIPKPFSAMLEPIYGYISELDENGVASYRERVLAHIRRDFASLPAYACSLLVAIINEFNIAAARDRSDYLKVALLLRFFVTAHTECIAPAGGSLGAAEESDNSESTCAVEDDVATVAATSPPEMGGVREVLRVHGQSALEAVPKDEFSCSSRDALGYLEALEDAIHDRILTPYVEHFYSATMEKLRMCVSGDSLQRLMSPATDAGERYDVFALHYMLTKRVRQSSRHTAGIRLCPLNPYNGWTPSSAFLGVNITSWQSGTAHPATTGWSHRRGGSESVGGDAESSSTSANTRHNTSERYEDSKGRVSNRHPQPPAGLHGKFDTSNVGGGNFERRNRASAGSVGASDTRTRENIKRLECAYVPTESAAQCPPSTTASHALRHSTQHPDHAHGASSADAKKPLRSPASHESVSSMDNPQSDRDQGHVRSEDELAAVYRDFGCVFTASSFTLWSQLPELHRVLALQPLRAHAHLQRLLSAFDWLLLQSIRSCGVPQDQRSMPKLGAFVLHHQHIETVDGSPSDGASSISILARRVNAVESVATLLELLHRKVDVTLVRCAEVADAHYTSRFGVVAELRAYVYPLCMLSLLNKKIPTEGILQALHSRHVGYTRQSSEISELYAAFVNHIRQIWEFVEAADGGSIPLPVKALLWRYACIVVRGALRPVVEVLKRLQVHYEVATAANGGCKWAQEICNEMYTAYRADALAAAAREQTQVTHLAAYVHLLADMRENWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD21</accession>
    <name>A0A061DD21_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768061.1">
        <property type="nucleotide sequence ID" value="XM_012912607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD21"/>
    <dbReference type="GeneID" id="24564416"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210280"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="243" mass="27229" checksum="F84BEB9AB91EFF70" modified="2014-09-03" version="1">MKCKCNDIRCGCKDDCNKDGYGKCKGIKNQSCQRCQRRCKPEGPCICYFCNCGTHCNGVICSCCKWCDPRNCSGEECNGYVIGRCPDGIECRGHVKYDIYDKDNNYGALLDRNDKNRIECDGKPHPGKKCTESNCNWLSGVRDINGNCVIKCTYCGKLCGQDNFRRCCTIAIPLVIIVLAFLIFRFMLPEKFHAITTKIRAAFPSSPRYPGRSLSNLSGGRIPEEMSVDRYPAVRPRAYAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD22</accession>
    <name>A0A061DD22_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768066.1">
        <property type="nucleotide sequence ID" value="XM_012912612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD22"/>
    <dbReference type="STRING" id="5866.A0A061DD22"/>
    <dbReference type="GeneID" id="24564421"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210330"/>
    <dbReference type="OMA" id="CPNIFWN"/>
    <dbReference type="OrthoDB" id="5560686at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="741"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="881" mass="98936" checksum="5C862CC6F7A9F112" modified="2014-09-03" version="1">MVSSPRFPHSRCSVISGIFSDSKESTNDDYDFGRGSPSSGRSQSSVNCTPYLIPPSSCTVDRSGPQTRSETDSCEKLFFSPGEIGSFPVTDELPDKAMDDEGADMEFSTPTVMMKAERGEEGDQLYGNTDGVNEEKLDSATDNDVVTRTPVLTRQSSAKMRNAKAEDTSEVDQPMGISSFVKAALYGQRGEKFRLFWLPNYEVSSLMRVPSIAQLSDTRRDSAERLYMVYTAGGMDILQDVSDIAGVERRPFETPFVVLYSYSFKSMYFKVVGKMVESCSTVTFENDGDSTKIVNEEDDDDEVEVTSRSKSKGAAPTAGYAFYRSCLYGLDDRKKPMRIKVSVRSIKDSELDLRAASASNEEASHYRAALNSRVAENDSESKNSLQSALLESLSRNDMRSSKDLASSRSLDSIQFDGGVPSSAEGSNKQVVKGKRRGTWVYATTIDHDEGGDEMVHGLPAVLLAELRWLLRLEDTSTLSQCNVSMVNPRIEAMIKQNFELYDRDEQQLTSNVKRDLVEVTTKEPDSLAMYNIGDHVVSEGDILTVRFRTLYRGYSEEDTMKVYSKKAIELFFETLSSLNLDGVTDLTMDIAQFCPNVFWNLALTGDFEGSLKRMVPNMVGNTRKRRRNAAKADSPVITSNRILPVAKSNYSPVFDNNFVIMQNLLERDAQKKIAHLDKIREQQRDLNGMLLRNTVSKYLDADELISTVMDADGFMLKSMQGLTAAQRNVVYKTYLKRGLFAPVRLDYIPAKGRAVFAAYDITKGDFVVEYKGQIITEKVAKIRDQKYDKSRSYKGSFVFYFRIHTKRYCIDATEEDITFGPARLINHSRRNPNVVPKALEIDGCPRLFFVAKRDIKSGEELLIDYGERDPSVIKDNPWLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD48</accession>
    <name>A0A061DD48_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-AMP-ACTIVATED PROTEIN KINASE,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0002850</name>
        <name evidence="4" type="ORF">BBBOND_0210980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK055082">
        <property type="protein sequence ID" value="CDR71627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768136.1">
        <property type="nucleotide sequence ID" value="XM_012912682.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770574.1">
        <property type="nucleotide sequence ID" value="XM_012915120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD48"/>
    <dbReference type="STRING" id="5866.A0A061DD48"/>
    <dbReference type="GeneID" id="24561850"/>
    <dbReference type="GeneID" id="24564491"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0002850"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0002850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210980"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="2">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR71627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="355" mass="38972" checksum="70D3AE7B0E11B662" modified="2014-09-03" version="1">MSSRERCAAGRLSCVQRSSHAAAMTTNGAFQGFVSSGDSMYGHAGDSDVSDVSAGAAAPYDPAAYALPSDSIPSQAYATASTAVESLGSVAAALPPAPVASATPTNLKADSVFEGLRWSEEIAPYFSEIRDIGNWVQPDPPAKDKVTAVFNWNHGGREVYLVYKEDGETKQIRMFRNGNSFMLVRDVPKAMVEYTFLVDGVEQCAPDQPYQRTADGVKNVMDCVNVLSVEAVVEADELDPFEGHFDQTMPDMRYMAQEAQVVPNALLYRSPNFKDGDRVDNDIHIMANHLYEDTMSEEVLGRNYKSYINIYCWETSTPDISLSRNSASVIYVTKAPYEAEPESEAQAQKWFNVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD55</accession>
    <name>A0A061DD55_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L18, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0310220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769305.1">
        <property type="nucleotide sequence ID" value="XM_012913851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD55"/>
    <dbReference type="STRING" id="5866.A0A061DD55"/>
    <dbReference type="GeneID" id="24565660"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310220"/>
    <dbReference type="OMA" id="MSKANRP"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="150"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="250" mass="27512" checksum="62C1E596B063FE58" modified="2014-09-03" version="1">MCVMSRRGRFQRGEGRHLCNLSGPPSGGSASPGSFLPLRGIDLKKGGRVKKPGRKALVSKDPYLRLLVKTYKTLARRTSSAFNRTVLKRLLMPRRFKAPISLSKLIKHMKGRENTTAVVVGTVTGTLLYRDMMMYVSTESRRSSDSAGEDDLRVNEVPKLSVCALRITRTAQARLLKAGGEVLTFDELVARSPTGSKCTLLRGATKAREAEKHFGKAPGTPGSSTKPYVRSKGRKFEKARGRRKSCGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA0</accession>
    <name>A0A061DDA0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0212320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768276.1">
        <property type="nucleotide sequence ID" value="XM_012912822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDA0"/>
    <dbReference type="GeneID" id="24564631"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212320"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="240" mass="25833" checksum="D63E386639B9019F" modified="2014-09-03" version="1">MRGLGAAVVVLQLVEGSGRGSGTCCSRLRGVGAAVVEGTGSGSGSVAVEGTGSGSGEGEGKMATYYKCECGTNCRYPNCYCCPWCCDKCNASWTCSGCWLHYNKRTSGLWTYDCETQKCAKQCKNKEYQCKCTCCRGKQERGEAVRPPAPQPPLTSSGAQDHATSERQQSGLSDLQPPTDDLHEQASTPFRPDPQAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFIVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDC1</accession>
    <name>A0A061DDC1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bax inhibitor-1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0300500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768331.1">
        <property type="nucleotide sequence ID" value="XM_012912877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDC1"/>
    <dbReference type="STRING" id="5866.A0A061DDC1"/>
    <dbReference type="GeneID" id="24564686"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300500"/>
    <dbReference type="OMA" id="SRDFIMH"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF32">
        <property type="entry name" value="BAX INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="28133" checksum="AE49E90C7EAE91C6" modified="2014-09-03" version="1">MFDNQFFQRSSLWQASTLLDFTPLSKAQREHLTKVYATLALCTVITFAGAIVPLRYLNHHSVLIGLAYICLALYVVFSGPRVGGQQQPISVKRCLALSGMAFAQGLLLRELVIFVLYLNPEILTTSLFATIAIFACFSIASLCMSSRLALYLGGLATSVSFYIVLVRLTNIFIRSKFVDDVSDIVMLLSFCGFIILDTQITLRAFDHGSRDYVLHAVMLYCDILNVFLKITKILCKKEEKKKEKSESRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDD0</accession>
    <name>A0A061DDD0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0300750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768356.1">
        <property type="nucleotide sequence ID" value="XM_012912902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDD0"/>
    <dbReference type="STRING" id="5866.A0A061DDD0"/>
    <dbReference type="GeneID" id="24564711"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300750"/>
    <dbReference type="OMA" id="YTRDVCL"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF6">
        <property type="entry name" value="FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="3">
        <location>
            <begin position="223"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="530" mass="59538" checksum="F4BCB87763303129" modified="2014-09-03" version="1">MPSAKLDTCVLVVGAGPVGVTLQLLLSRLGVPCVLAERNVLPRRHPRAHYVSNRSMEVWRQLGHIDKAIESVSEPLECWRYFKYGRHITDPHLNLYGTVDHFRDAYTYKDTYFEELSPSRITNMPQHKLLFLLKTIALRRSHAFPATSDDAYLSWVKTQYEYVMKTSKFDDAKLRKLSQVRGPTILPVDIHSMACDQELTDTGIPFIDGGLRFDRFVDDDMSSGVVSELTSTKDDKKIHIRSAFVVGADGIHSKVRRYIDGKRCDATSSRSDSNLLRDVMSIYFSSAHLGSLVESNPAMIYFIFSRGGRPAEFVVQLPFFSEMEDPVVYDEATCISHINEAVGVPLTDIRIINIKKWTVSTEIAKSFVDTDSYRVMVAGDAAHIVAPAGGQGMNMGIADTYNLAWRLGRLFYRRILKARTSDTPPSTSDIVGQKLSESEKRSILEYDSERRAVAEVSVMCNSCQWTQYTRDVCLAEIANGSKFASYLHYDHATMHSLMGLLPPIGPLASKVVCNAFDFVKTAVSTKLKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDM3</accession>
    <name>A0A061DDM3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor, CC1-like family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768566.1">
        <property type="nucleotide sequence ID" value="XM_012913112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDM3"/>
    <dbReference type="STRING" id="5866.A0A061DDM3"/>
    <dbReference type="GeneID" id="24564921"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302840"/>
    <dbReference type="OMA" id="RYFAGNT"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="247"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="401"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="490" mass="55350" checksum="62176B03B057825D" modified="2014-09-03" version="1">METADVADVGKVIPDRDRESREPRDKSPSRYHRRDRSMSRSPRRYHRSRRHSDSYSSSRGHRERSHRRHSRHSRSISRDRESSRRRHSRSTRRERSPSRQRSYRESEKRSRARDERAPVDPEERARLEHEQRRQREIEEAQREDLTVLVINLHLGADERKIYEAFSEHAGKVRDVQCVRDARSGRSKGVAYVEFYTQESVIKALAMNGFELNGQRIRVQSSQAEKNRAARAAKLIQQQTVEVADSPFTVQVTGLTGSLSAITEVEIKQMFSPFGTIINVEIMRDPHSGLPLGHAFLKFKRASEAKEAVSAMNGFDIGGQTIKVAYATGANATGRLASHGEVDIERLDEDGGGLISGANNKIALMHKLQRTSSSDTAGAAQSAQSVAHTGISNAPTCNVILNNMFSSSDPTVSEPNFFSEVEEDVNDECNKYGKVVKVYINRQAVDGKVWVKFGNLLDATVAYRSLNGRVFAGNTIKVEYVTDDHWQKMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDQ6</accession>
    <name>A0A061DDQ6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0303790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768661.1">
        <property type="nucleotide sequence ID" value="XM_012913207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDQ6"/>
    <dbReference type="GeneID" id="24565016"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303790"/>
    <dbReference type="OMA" id="SHDIANI"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="463" mass="50284" checksum="E85822E2EA52E243" modified="2014-09-03" version="1">MTKSQADSSKEKGDYNVLGKSLYNLVSFIEGYDQQVLSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCLIWGLLADTNESRYVLGAGLLLMGVASIFLSSASHYKVQKIVAESDDSKESNTSNGETGQQQTNKKPKSSSKFTIFQALNCIGRLLCAVITTIIARKVLLGYYGWRTSYVVLGYIWILFAIGVVFGMELKKSSTGDDSRAPSSSTSGTPSERFTDKVSGAFSAVFKCNTAGICIFTLFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSGAGGKIIDKIGEYCPEYGELASGIAVMFVRLVVCLLFFLGKPPCGRLLWYHYVELATLGGTLVTVGGVDRAIMRDSIEDKHQATAAAIIRTISGISSSVILYQVSAYLTESLFGYVPSRESFETMATDIKERNAEALRKSMMYIILAGTLLNVVCYIAMCFTYDNERQSKKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU2</accession>
    <name>A0A061DDU2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768761.1">
        <property type="nucleotide sequence ID" value="XM_012913307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDU2"/>
    <dbReference type="GeneID" id="24565116"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304780"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="62" mass="6625" checksum="63B8D2E4D0BCEF3C" modified="2014-09-03" version="1">MEIAHTVNNFMYCAKEETTQLSSAVVLYVISVTSTYVNVDVVGGGVHGVPPLPPLPPLSFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDX1</accession>
    <name>A0A061DDX1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769945.1">
        <property type="nucleotide sequence ID" value="XM_012914491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDX1"/>
    <dbReference type="GeneID" id="24566300"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402470"/>
    <dbReference type="OMA" id="VRICKSI"/>
    <dbReference type="OrthoDB" id="366339at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="520" mass="58310" checksum="E2466A5484D12D7B" modified="2014-09-03" version="1">MFGVTRSLARFLVLVTCLSVCLLTTYDWLWRHMPVVSLEDVSAFWRSNEANIACLRAGSCNLSFSSFWVSTVFGATNCTQTNKYLWNPDAVTDVRRAALPEAVAASAPPLWLEALCLTLSLFTLAVYTVILCYIIWVRHVRLLCDALSLLFRALRHVDWNSPLHAMRASYKFGCYLYASFVHVWSVISLRERHVLICASGIFCAIASIRIGLGRRGLRCVIPLGLASSLYYCAAMFLKRSSQRQLTVFFGSHLPPLWLLSMLFRRYRLLFCPTLKIVEKPESSTGIAHEMGCLIDLFIISTLLQIFAMVPLIGSFLLRPFYIQHIMCFMSVLMVLHCAIAKWFNRDLVVSPLGRVKTLIVVSIDTAVNLAVGWPRILSSRISSQRRSGGFMQDYGTRIRSAISLLFPSATDRFAGFKGLASALRWLTLMPHLLVFLLPNILSRLYFSYLTLLSPIIRGLMLGNCCSFRSQTVVALNFVLAGAARWLASSFRISLLPIHTVLCLALPVCMDLVVRCVEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDX7</accession>
    <name>A0A061DDX7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0305740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768856.1">
        <property type="nucleotide sequence ID" value="XM_012913402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDX7"/>
    <dbReference type="STRING" id="5866.A0A061DDX7"/>
    <dbReference type="GeneID" id="24565211"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305740"/>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000108">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="3">
        <location>
            <begin position="101"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="443" mass="50415" checksum="3E589FBCFA5B1FF7" modified="2014-09-03" version="1">MNNGLRSLFASVSRVASARRALRCSYFSSVAKRPENPRVFENPADFKPYVLGLRYTEFTNRLELIEDSPVIPIFQVMDVEGNFLGDWKNPFPSDEAVLEHYKTMVRLSIWDNLFYNIQRQGRISFYIQNQGEEAMQVGCGLALKHEDHIFGQYRELGVLYCKGFTVDDTLNQLFANKGDECKGRQMPISYSKKECNIHAICTPLTSQLPHAAGAGYALKLQKAAACAVGFFGEGAASEGDFHAAMNMAAVRQSQTIFACRNNGYAISTPVCDQYYGDGIAIRGVAYGMPTIRVDGNDLFASYIATKHAREHCVTRSTPICIEYMTYRLGHHSTSDESSQYRGPGEFDVWTAGGNNGINRVRKYLEKQGLWDEERDEALRKEARSFMLKKIREVEVVKHVDLSSGIFDDVYDQPHPMLEQQREEFLEHLNRYGENYKLERYEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDZ0</accession>
    <name>A0A061DDZ0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma tubulin complex component protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0402820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769980.1">
        <property type="nucleotide sequence ID" value="XM_012914526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDZ0"/>
    <dbReference type="STRING" id="5866.A0A061DDZ0"/>
    <dbReference type="GeneID" id="24566335"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402820"/>
    <dbReference type="OMA" id="EMSHFAN"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="6">
        <location>
            <begin position="229"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="774" mass="87217" checksum="5CDA7A6706EE5001" modified="2014-09-03" version="1">MLLAYHLSQINKDDIVLYNLDTLNTSRSLNSAGGGSVSGSARSTGHIVRLHASLQRHLEETTMRLLAECAELEVVEIDTNRIARDLELFCVDRSNVSLRRLKGLLYAGMQSFERLPASLQLLLHLKDGGGPIRMRTSPMLRDELGEDSLPPSPLSQHSPPTATAASPAPSQPIEVAPSSDGSSGYASPETIDSDPALSPAAGVQAEDPVASRVVTDRFEFAEIDEADLVSDLLFVLQGIEGRFIKRGAHGRFILTSSRKVSRGVRQLTERICSLGEVYNRIVDAKMPPGLISQALYQGVMDEVHQYNRLVNMLVSSRSTEPLSLRRLYVWVQQPYARMRLLHSALGLPQGFTIDGIFDLYCGRGDTMGRELYCELLRKCMVPYLELLLHWVYFGELEDACGVFFVRRVQGHYRLAPSKVPKFMPRSLAELCFEVGCCGSYYSQLKNGRPLKASVDIPGVLRQLCPEGQPWSVFVTVQRLCTLVRSVDTGAVLLQELVGKHDLCGYLRRVKGHLAMEHLGSDPSAPEFDDFECNAEYGFDIYVPKFSFPLALILEDEKEAREAYIISFRLEFVLQRALKILSISWSEYAWHSRCSHGSLELSRRLSWINLCRNEMSHFANVLQGSRSVQYVLDQLIRRVSSRDYPYGGATLADLRSSFSDVLACFRASNFLEIMDILESIVDFCKLVPRLFNRGSMQQLRSLVREGASPADITHFIHQNIATDDLMKVMSRYAERFRESVLLLLHRLSCQDSERRRFAAIMDYNNFYRLLSVIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDZ1</accession>
    <name>A0A061DDZ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769985.1">
        <property type="nucleotide sequence ID" value="XM_012914531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDZ1"/>
    <dbReference type="GeneID" id="24566340"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402870"/>
    <dbReference type="OrthoDB" id="366787at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600305" evidence="2">
        <location>
            <begin position="29"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="376" mass="42593" checksum="0199293313F95428" modified="2014-09-03" version="1">MAKSTLITGWKRIVLVVLVLTFANGTTAQINVKRFRHTLNDDLRIYVNGQRTLYSEIQFEKEPTKHYMFALKYEHLKKTTQFLRDVFTHYQGLHPFKPYLGMIVEFYERKLAEANGSSFFELKPNELCAEVAGSLTGITDTVVELSPLYHLNRPDVIDAISCFRSAPVKAQEDIMDFWMLLYQSLYTKCSETLQNFDMENTVNGFQVESGVTTPASLRGVGDAIGYDEPAFVDLIEHESDEAPWLREDEAGASPCIAGSLGAWKPETDRSLEASDASGEMAGSSNDDRGCDNISGACDSRTEHHDFDSSSDSYFKPEKPEEDEDPLWDEYFASFLMRLKNRSDQSGGDACRLLGERCRHVWNVPLSTAIHNYSYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE06</accession>
    <name>A0A061DE06_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770030.1">
        <property type="nucleotide sequence ID" value="XM_012914576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE06"/>
    <dbReference type="GeneID" id="24566385"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403320"/>
    <dbReference type="OMA" id="WHTVSYI"/>
    <dbReference type="OrthoDB" id="359818at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="845" mass="94413" checksum="07965E4970A79267" modified="2014-09-03" version="1">MAKLEDVLVDAEAVYTCNYLLKCYSDDFGVDVLTEVPDINVAAASFLSEVAGKSAEQVKATLDRLNHALLVVSALRHKGVLNNTSDIIKSEEEVNTFLGLLNEVSESVGVLRSDVESRYGHSISLYRSLEDDIACLDGICKAQAYVVECMGVLSGLRELKSESHSLETLDGYAALLNTSHKLGKIISRVAAMQKTDVSSIISRQCEELKAELVNLASEKGVSALIRQHMTSGSNDIVDEGTLKRLAICHYILKELAVTPSYTLRLVDEMVASTGRCINLDQLLRSGTRDDMWQQFLISQLAEFMAKYKSCLMALHTFCRSVNYRLSEHLNEEEERITKVCPLLSQPLRKQHDPLEVFAACELYVKRCVGILHTALTQLESQSPSSGRFDVAMLAPQLISIGECTHKELCHLNIPFNMHAHYFTVVCERYAKEFMTNAAARMLPASQTAFAACLKVLHQNGVRNFKGLSPDRELQLAASVVHSVPVDVGLARVMYDFLDKSHSCETLHRHVLEVANSALQHILRAAEDVSTVSGSRLLLSDGGSKISLKRPTDAHRINARIYHYILSFVDVIEPCLVMPMDKESKLYGTVQSCKNLKVIDCWADDVGATLWHTVSYISSGNCQEFGWQAQQVLTATQNIVKICNFLRENYFNPLVPYGRLRLFRRLATHAISCFVVYALTVWPLEENDKISLLGVVTELEMELAEILKESVPKLESDFLAALRRLLYLGDELYDVIDSPDFQTSACLKLPLDLISLHVMTRIVNSTHVSTSMREELLRSPLHQYWKTSSIHNVLDSFRNTMLRYDPSVPCSPMFGKKLAAYLKQFGSFESLLSGQLSGAFSFLDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE18</accession>
    <name>A0A061DE18_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0306690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768951.1">
        <property type="nucleotide sequence ID" value="XM_012913497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE18"/>
    <dbReference type="GeneID" id="24565306"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306690"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="827"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="963" mass="108424" checksum="446F94777D090488" modified="2014-09-03" version="1">MAKFIGAPLAICAIILQFIKFINALQYDFSSSLRSLVADALVASHINMDDLGMATLMCPRQINGIEYVWHPQPTADHNFCLETYVIENGEFHSVPLSTVVITEIRRLNFWKTSRPSQTDLHIDLMDDYIYAITENRFVFICGPRGLVLSEALQAQLASLDGFAEIDAHPWEPRTPLVDEIAKIGGSLGVVFLHRGRKHKLMQGCGSRPSPLFASDNVTVDSETGTRSCMVDPMSELPIGFICQGRIEPDDCMKYLLDKTDGVVTAPTPHLYRNFNHRGKWVIAQYFDGLALRAFKGECRCINPKTGRVKARIEVRWKTEYICDITSMIARNRFNPISGPWCSVMLHPGATLTIKLPKQTVKSAAADLEFEEDGDVEEDALTAPFSQLPSIHEYETEFKPDVSLILRQRQTIYDIDLYDEILIQDALTGGAFEVDVSQMEGGEVKLKYRMDKPLALRSGYNSFLYHWTFISRNENVLEKIRAVVNVSFAPTYRYNIIGCDRWKPGMFDPANDSESLAIKVVGNGMALTSEWLVNVSSGEQQAGIQCGRNEDLFPNNCESTGYDISSNQVAPFPTSVRNATLYPVRGFQVFDMSFQNVPVSHACSCVDEHGYETSRLVLRSNRYEEYTYTVSREAAYQWLMPYSLLPWNEVALFYGDHTHMQSIMLHNMPQIPIKLHSGTKILMRCVLDEGVYDDENDAVVPPTWLPDYPRHHHYKVDTTTYGPMLISKLNGERIAGTKGGLDISISEYTDEYCDLAITSNSGAILVSKDPDHSEYVPITFVCGKELSESDFGQVNDNALAADIPPPVAPLEDYTWNVVQIDVEMTDPYMQGCGITDSRDMFFKPETPKLYDTYRQLQFGCKINIQAAEEAAFYCPAPYVLDPPNCFYQVSVNGEVKNLMDISQSLVASRTNHFVTLKFDSARIGPGETLHQTPPLECRCVTIKGVILSTIQIENYYSKEWVAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE36</accession>
    <name>A0A061DE36_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768976.1">
        <property type="nucleotide sequence ID" value="XM_012913522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE36"/>
    <dbReference type="GeneID" id="24565331"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306940"/>
    <dbReference type="OrthoDB" id="10434371at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="194" mass="22099" checksum="03FA64E1C93B7F68" modified="2014-09-03" version="1">MASIRYYGRQVVTSLLCFYMIVFYESAMGNPGAERSQHAEKLRGKNIAFYAANAELHLNLEHLTTLYVSAEKLHRNLCAIADEISDSDAPEENKRIELEGCSGAIKLVEDVIRDAKYYVELAGILDEYITLSRESKKTGTTSERAAELKNALRSLEQRFKNKEQLALHLLTYGIGEYYVNFMREAEAFIHKYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE38</accession>
    <name>A0A061DE38_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770140.1">
        <property type="nucleotide sequence ID" value="XM_012914686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE38"/>
    <dbReference type="GeneID" id="24566495"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404420"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="7913" checksum="44AA7A2B76668147" modified="2014-09-03" version="1">MAAVTPSSQKALEMCDTPSGFLRNTIANVPIAIINQDILQGHIDTHVKWEDLMEMDFNCRTFQFVVLCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE41</accession>
    <name>A0A061DE41_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0404510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770150.1">
        <property type="nucleotide sequence ID" value="XM_012914696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE41"/>
    <dbReference type="STRING" id="5866.A0A061DE41"/>
    <dbReference type="GeneID" id="24566505"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404510"/>
    <dbReference type="OMA" id="CMARANC"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="14"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="278" mass="31161" checksum="B1265B3E42F785F6" modified="2014-09-03" version="1">MWNDSSGNASKAKFKRASCQENETFYLYQQSQKKLVFDRNEEPLLSLRYKDRNIRVLDDRLTAVGYKGWASVFSSHCARKGKWYYEVRILDGCDTINFIGSDGEITIPVQGHVRQVRHTLVGFACRYQKFQVPIGYNNFGYALSDVDGTVVNDGSKSPYAKPFGPGDVIGCYLSLGEPSGVIQDPRKDLKLLEHLQAGILCDPRDPPAMELNAGSYVGFSINGEKFGECGLKVWDGYYHPAAALYMGATVKFNFGPDFDFPPPDDFSPCRKMMLPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE92</accession>
    <name>A0A061DE92_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770265.1">
        <property type="nucleotide sequence ID" value="XM_012914811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE92"/>
    <dbReference type="GeneID" id="24566620"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405640"/>
    <dbReference type="OMA" id="NDELCKY"/>
    <dbReference type="OrthoDB" id="437309at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="290" mass="32959" checksum="F624C80666ED44EE" modified="2014-09-03" version="1">MSSAPAESSEVSDRKIVLIWQLKLSACLAGVVVSAYGAYVVISSGFQLDKCRRKFSLHWNGLLYGNSLPVRVSALLNSQYNVCLQPDVLRSLSTYFIKFDLTKENGFRRSDALMFLETVEIATDDPIVDRFIAAGVGESREHRMVSGCSLQEFAELLEALVLDSRMKGDDQLEIKIKQQLEEVNGEAASDAGQPLKEFRLNNPFLLNKAKSLSKELHKHMQEDFKVSEITDIQHELQRNYNFRDKLQRIGTSRKLTDAEVRRLENVNQEIYLLEEELSKQKHVCNLVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DED9</accession>
    <name>A0A061DED9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769296.1">
        <property type="nucleotide sequence ID" value="XM_012913842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DED9"/>
    <dbReference type="GeneID" id="24565651"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310130"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="74" mass="7972" checksum="8FD3C7E53F23D7FF" modified="2014-09-03" version="1">MASEAPPASNVTHEDEFSPPGLDHDALHYSKVHQDAVINDSEVPNPLAEVVYNPPIGLSTDEVNRRIIAILTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEF0</accession>
    <name>A0A061DEF0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0310680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769351.1">
        <property type="nucleotide sequence ID" value="XM_012913897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEF0"/>
    <dbReference type="STRING" id="5866.A0A061DEF0"/>
    <dbReference type="GeneID" id="24565706"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310680"/>
    <dbReference type="OMA" id="VGRFNEX"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="10">
        <location>
            <begin position="282"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="509"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="664"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="13">
        <location>
            <begin position="731"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="616"/>
            <end position="618"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="623"/>
            <end position="629"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="882" mass="97748" checksum="B58B5EF0CA4D7C45" modified="2014-09-03" version="1">MKKKVTSDIRSLVEHAVETGERCLFVIVGDKGRLQVSNLHYLHQRVSGNKAKVLWCYKKNLEMSSHHRKRHKMQKKLAYKGLYDEATEDPYELFLRTTEIRYCYYKESQKVLGQTFGFLVLQDFEALTPNVLCRTVETVQGGGIIILLLHTMSSLNQLYEISMDIHAKLVSHGHSTIEPRFVKRFIYSLASARNTIVVDDELNVLPIAKMTLSDLTKSRSDKKLSKLQLSLSSSEEDALEMKILTKISTLCIKHGQLKALITLFNAVSKGAEIQQRLNITTILSARGRGKSATIGLFLSSALNMGFRNILIVAPAVENVQTLYSFLESGLQLLGTPDNSKVVVSRKDGYVECLTLTVRGSTCVKFVESSTIDPKVGANNYLFDILIIEEAASIPLPIVESLCKKGIVIISSTVGGYEGTGRSLSLKLIERFRNTIPDALTEITLKEPIRYSKNDSIENWLNGVLCLGTPVDDPKERTTLPPPNKCQLYLVNRDVLFSYHSKAESFLNSITAVLSSSHYRNSPDDLLLLSDAPAHKLFVLMAPGLESEDQDSVSALESRVFCVLHVAIEGRISKLVAKEAVAQGTTKKSGDLIPWTLTQNFCSEDFCQLLGVRIVRIAVPQALQNMGYGSECLSQFISCVNGAVNQVPASDSLLVPVDPAAALEDGAEKVDYVGTCFGLNSQLLKYWIKQSFKPVYCRQVPNEATGEFSIILLRATDNAASASESDGAQKEWLSEFCSDFSRRLLGLSGSCWRSLPATLVLMLLTASSEHIKAHDDKTLLEVFTSFDLGRLERYSAQLAEFTLVTDLLPIMCRFVFEKKVDISLSYLQCAILLGIGCQGKSPMALSQELNMPLNQTMALLHKSVSKFSKKLSQLEKEQVANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEI2</accession>
    <name>A0A061DEI2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769511.1">
        <property type="nucleotide sequence ID" value="XM_012914057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565866"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312280"/>
    <dbReference type="OMA" id="EEELYGW"/>
    <dbReference type="OrthoDB" id="360640at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1670" mass="186056" checksum="387811A18D7AF579" modified="2014-09-03" version="1">MVVAARGESVWAVPRPAAACITELRLFQQHCDRVFHDLYARRSFARLQRQAERNIHAVDVLTGASYARRARTVVVDAGHRVPERAYDYSSHFVGVVRSTGAAQHPISYSSAFRTVVFTKAVRICREEFANIATVDLLLLAYDVYTALYLSLIDALIHLGSWDEATEVLMQLGVVLYFIRSDLNKKQRSLVGATADARTEFRRRLFNCVLAKRGISLDDMPCCTDNSAIVQHVFDCFMLELPLETWSRTVYLWLRDASLYSVLETLQALPLPQRSEFYRRVRRGLLFATDTEDTDSPDLPYFDAESWSSKPPVWKAARPRGSGGCFGAQRWGRKRGIPYDFVLGCVLSASNCCRRYALEGLVMVAKISMALDRELYAALCFTVCMVLRVLSSKIRLLDEISFENGVSQGAGGHEDAATDPPLSVDHLSSLLQYVGMNHWENQKSLCVMSSIDNVWVRRSGMRSLSVSLTPVASFLGTSRYNGHSWVGLDYVVMLDVDGMIQCDAAGLDGIRFVPSRRVDGQFSPLGEMKIVRSDHDKTKSPSGAGCTGSICLENLKVRNNSVDVQMDFTPLCNNMCHSGRRYKRAPPSRGTKLAFSVVSKPPDHVPQPLVLGFDHKLVLALFAFCVSVDREYAVLHFRQALEYLNYRDTLRKKRKAFLRKLMTWVPTPNSKEARNMMKFQKRIRTAFRHRSWLSYMTATGGNEDHAHDADGAEWLPPLPPTKGGDAVNVKEYLSMESAELRMHYNGNNCLKETMMAKNRVMDVVEKYRSAVSQATNYLYKKCINYRPFCKTGALRGSHYRLGIKYPFVETEEAEMGAAKPTRSSMPPCEHTAMTLSMDECTQCSTSQSFRQLDRMITLTEWISHLVFTGCIRPGKVHPRSLPIGTPVDPHRAMPSAASGGANRLAKKLAGKKRARRVDRRSYRIMEYVVDAYVPDRLAGTAMANLSDGLALLNEVVESCMLTSLATFFHEPYYKGLVLDLALVQLLQGRWSLCLALLKQLRGPPGNYSTPFGAETITLPIEVFRLTKVEKEFLSRLTGKIFTELIMEPQLSIEMLSQECEPVDIGLTDGNDHCATHSGKGPGVAVSSHPDNFGMGLSAKSLLLLGVSYLRLGIVQVDPLSASIGDTTGSWVHIDHPELDNLRSFECDAPNSVAVCREYYPQAPGDAAVADPDTPTGRLATASEHILKALSIDPLCHKAWLYLAHCGVLAHEYEFAYRCCQRSIDCYDACVAAWLTMAVALSSRSRSCPPVKLSDGVWTEYLVEQKRLTQRMHHDKPTKISIPSFVVPYDPVFPSRAETTDDLARHMNQAVGGDTAECLDVLITATRFGSVFAYAGVLQLLSRTVETPIHSFPWESSNVAASSSRVVLTQLYLVLHASIECASQSTLAKIPDEWLHPDPRKMHSHMRALVSRAVSAKLHVSSLPFIRAMCLMYSLDVVDVSRAAVLSRGEMSFEVGLTDAACFEDEVYGWITCLEVLMQSGHAATAELLFPLLELYLDVSSPRCLEAEYAAPSCDKLPVGPHAEESRWGAVRRHFNGRAFTYADLRAETVFLRLYMRCYTAAEGELDELLSDVQDAITQCASRKLRLLEARVLAGLRRYEQAARVFAAELRRGFTGSVSTDYMLECQAMKVYAKVLTALGEVSQSAAATAFAEQCYLTTPVLRCDLCLVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEJ7</accession>
    <name>A0A061DEJ7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769586.1">
        <property type="nucleotide sequence ID" value="XM_012914132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEJ7"/>
    <dbReference type="GeneID" id="24565941"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313030"/>
    <dbReference type="OMA" id="PEYIANS"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40710" checksum="CFCA7BE1275E0BB1" modified="2014-09-03" version="1">MYVLRLFGPLLRQHRRPLGYTALVPLCRAVDAGGRQSRRHFTTDDTTDRFRHVSESLPHRQSAHEGPEYTGQSTGQWSDESPGAPSAPSERGEKPKLDKAAIKSIPLETIEDAVLKFVPETIRESSLDDDFLTPGQAFYLENRDKLFDQLRRRYFEATSEGGGDQVTDGEIESMLPLLMEEEQFGCYDPEPVVSPGKHHLWDYNTSEVSAPRRNVHLRKGEMPTLQQVVEILEQERMSNVVVVDMDSCNRRDQAMYCIVATGMTKAHCRRVGRLIYRAIVDLEVPFVSRTAYCCHSRNDEWIVARLGPLCVHLLVKEVRERQSIEDLWAESRAADTDHVAGSITEPENSPADHTTHKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEV0</accession>
    <name>A0A061DEV0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal peptide containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770101.1">
        <property type="nucleotide sequence ID" value="XM_012914647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEV0"/>
    <dbReference type="GeneID" id="24566456"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404030"/>
    <dbReference type="OrthoDB" id="364620at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595772" description="Signal peptide containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="85008" checksum="724121933B737368" modified="2014-09-03" version="1">MALSGWCIALVALCLLETGKGQTETGGPPPNLGFLFERETLLSHDYTGFNVLIDLAMGNGAGEFFTRQVVAETKTHTRYVYKTKPSFSATRVIDGEQTIWECAYKHAEQVTIDEFGDCRLMQLQVDLGETPLELVYYEKTGASWTQIDRGKYVAEMFSRQVQDEIDMLPSAIKLLGSFKVTSIGNPIKPIGAQVVPLVGHVIKAVKCGRRTLWEYSPEARTLCIRVDKITASGVTLVILHFIETNERYRVAYMYGQGNRTMKMQKYRELYKVLSTVKPIRVPNVRLQFDVTVTADEAAKKVKLDDDGSEVDDDEDSDASRMGTPLIKIIEDGDVENALSHEQATLKTWTCEQLQADNSLVLQRAGGAVSWDMGSPQDQPGISISTIQQDLGDAKRNVVTPRRGTFMTYLVDGERKVYIAKDEYPHKVVKEFVANVGVLTVFATRLNGLVHRRYFLRRKGVWSETSKVGHYNSRKAIVLSRDIDIEELDTSNKIFYNNKFEGKWLAPYINIGPHDSTVDISPKYTYSFSRVIYKKQDLWVFNKAAFEMVTDIKIWQHGDERVLTIITVSGHDKRHERTFIMTNDKWDLVEEGAFVTAYKTPLVIDAAKSRQSGINKITAWPLLPNQDNTMRPLLGNYIHTVKYGDQVLWKHEGKDYMCDSVYNIKIRDVVIVTLKVFDRYGDTYYVYYLNDGTNSRWVEIDVVLLAFLVRNLQASRDFADILKKYEFTAGKFKDLIVKGATSQIVEPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEW1</accession>
    <name>A0A061DEW1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U3 small nucleolar ribonucleoprotein protein IMP3-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0404570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770156.1">
        <property type="nucleotide sequence ID" value="XM_012914702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEW1"/>
    <dbReference type="STRING" id="5866.A0A061DEW1"/>
    <dbReference type="GeneID" id="24566511"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404570"/>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="183" mass="21790" checksum="F8371CC58F8D0D16" modified="2014-09-03" version="1">MRQLKYHEQKLLKKVNLFDWKRVDTHRETKILRRYYIQDPEDYHKYNKIVGKITKLVSELRKLPEDDAFRIKMTDALLEKMYQMGLISVRGNLELCERLSASVFCRRRLATVLVQRKFCEHLKQAITYIEQGHIKVGLEIVNNPAYHVTRELEDHITWAQGSRIKEKVLDFTGARDDFELLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ55</accession>
    <name>A0A061CZ55_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0102350</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766092.1">
        <property type="nucleotide sequence ID" value="XM_012910638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ55"/>
    <dbReference type="STRING" id="5866.A0A061CZ55"/>
    <dbReference type="GeneID" id="24562447"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102350"/>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="364"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="582"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR93906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="842" mass="95829" checksum="34E22CDC79D60F5C" modified="2014-09-03" version="1">MLKGVSDPQNWGSLPFTVDGSEQWIRNFRDYSSLDLKKGHENRPVWVCPDGYLYLEQFTNVSRQAQDFLVTIAEPVCRPEFVHEYQVTVFSLYTAVSVGLTVEELLLNLNKFSKNKIPGKLKDSIIRTASFRTSGDGNGSQPLAYVPCIAVWQTSGDWPVVEAAIARGLNVLPNGKKSITAALPLHNVQAYLMLQAFGKIKLVLRDNRYWIESQDRKELDHLLTNAVIRSARIMGNTWDRGESHATNDTDYVTSAVFTADASSIMFNSANTGDAARPVMESNMPVAIEGMAKVKEEDRATSQVYSFEVYQEKIEELKREALKSMRRPLVMEYDFRKDKKTPTLECCVRTNIKIRYYQERALRRMFSNGRARSGIIVLPCGAGKTLTGIVAACTVRKPIFVLTTSAVAVEQWVKQFMDFTNISSEKLVSLTSDNKSDLWAADEAGVLISTYTMMAYSRKHRESTENILNQIKQRDWGLLIFDEVQFVPAPAFRRINEIVRSHCKLGLTATLVREDDLIKDLQWLIGPKLYEANWLELQEKGFLAKVICKEIWCPMTAPFYREYLRSDSAKKRRLWSCNPVKLATCEYLLKFHEARGDKVIVFSDNLFALLHVAKMLHRPFIYGKVTSAERIIILNKFKNENTFNSIILSKVGDNALDIPCANVVIQISFNFASRRQEAQRLGRILRPKSKTDENGFNAFFYSLVSKDTQEMVFADKRQQFIIDQGYAYNVTSSSEVVKDESNLVYCRPEIREELLQDIITACDENDDEEDELVHPDDPQSKVHTVDPALLVAGRERALSKLSGSLHKQSIKHHMANANRMKKGTRKLANQHPIFRKFFSGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZK5</accession>
    <name>A0A061CZK5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">41-2 protein antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0103700</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766242.1">
        <property type="nucleotide sequence ID" value="XM_012910788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZK5"/>
    <dbReference type="STRING" id="5866.A0A061CZK5"/>
    <dbReference type="GeneID" id="24562597"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103700"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="248"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="16">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR94056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="40822" checksum="29C625D595473F09" modified="2014-09-03" version="1">MDTAVSDPAASRQVLDQPLVRAKTKVSLSAFCFLFSEMVQYCMYTATRQATFTQRLHALGLDIGYRLLEMLSARERVAKRHANVVSVLSFISTTVWKHLFGHAAVLLKGKDDPREYMISDKELQITKFISTPKDLQHTSCAAFVAGMVEGMLRCSEFPAVVSAHNILEDNQEYSVTMLIKFEQAVLDRGGGEDRHSATFVVCTASRTQPFSELLFTMDAGGKIGGKIGGKIGGKVGGLGKGGKGKAGAGKGKKTPMSRAARAGLQFPVGRVHRMLKSRISADGRVGSTAAVYTSAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDTLIKATIAGGGVIPHIHKALMNKTPPQVLVKPPQPQPPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0L0</accession>
    <name>A0A061D0L0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766517.1">
        <property type="nucleotide sequence ID" value="XM_012911063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0L0"/>
    <dbReference type="GeneID" id="24562872"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106400"/>
    <dbReference type="OMA" id="CNHEARW"/>
    <dbReference type="OrthoDB" id="361942at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37091" checksum="71942E6C849FB7C7" modified="2014-09-03" version="1">MDRSRKPDFAKESRANANTSSRSRLLRAYSDLAFVCGCASDVHPGAAVFEPAASSARVRPPFRSSLECLLDRASEDSGVCADVSLRCVFDNLLRGAGIAEVTGASGSGKTSFCLSYANASPGVTLYVDTSGSVCLSRVVNRDKFILLRVFSCEELELVVSDFARRLSEDGYLPCFGDIRARSVAVLVIDSLWPVGLLDSYLRRRFLVRLCVTLRHISWQHNLAVLVCNHEARWDSWPSSVGKRGHRGWLRESFRSRCYVHVSLEQHACFGDNSEVHGIAYASGSSSGHSATGDSGGNPNSDGSSGSGFAVRRVMFICSGGEYGRRSIEFGVSNYGIVLHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Q5</accession>
    <name>A0A061D0Q5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MACROPHAGE ERYTHROBLAST ATTACHER-RELATED domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0106900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766567.1">
        <property type="nucleotide sequence ID" value="XM_012911113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Q5"/>
    <dbReference type="STRING" id="5866.A0A061D0Q5"/>
    <dbReference type="GeneID" id="24562922"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106900"/>
    <dbReference type="OMA" id="ILRMIMR"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="866"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="8">
        <location>
            <begin position="869"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="5">
        <location>
            <begin position="869"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="939" mass="103822" checksum="03002D66B304C6E6" modified="2014-09-03" version="1">MGSLLQDAISLEKRRKSLFSDLYAQIDSLKNLVEDAVVALSDTNGVNKTTVESAPTSTDKAAGNGSSEPSASVCNKGRANHGVSAAGAPGKATATAADKDQHDVGFRATLADLSKAVKSLDVYRRGSKITKEFKNQYLKLGKKCFKPGHNGDNQVLPPLDFDDQLVVQMIGMHLLHYGMFDVYEALKAEANERWGANCRAKVSGAVVRAYRILHDMLGKLRNNDINPLIDWVKRQVAGSHLHVDRFNALLLKLYKVQLLGDLYVFRDGEIQHQEFSLTPERISKVKSSGLSQMWNCHNANIGELLTQVLLGENLPSASEFLSLRLDTEKSFVRIFCESGVRIKRSESSAFSHLDSGKRTRRQRQGWDQKYEETSEKKSKALYAGNLSLEEELSQDDYLVRSKLPPEVKQNPVTVSWLGILEARSTSSGTSRNHEQPSRQSKRPTKILTKGWMNRLERGNPPRRSPRVNCSRLQSPSLSQSTDIYLAKMELIGYKTYRKQLYFMETLCAMNGDPETVCRQIIPDQPFRFDTFSLLHHDSDETDNQDDGYASSDDCEPEGDGHSSATAVLMNPGNNSDESFLNVTNVNQLALLAEYPLFLQTGTAQQHSQEFNVASSAEDPQQTLSLTVYTGPPVTSEEMYATQNAANESSTGGIAGRRIRITFPTRPSLVDVLPSHGHRIAFRGLRGNAEEAEPTSPGTGSSSTSRVEGERPTIVREPANINVRGILRMIMRGIAGDTSGSADTVVQLSPSTRTSLPSSGVRNESVATMRQAFATGLHAASRPKQGSFETAYVREDTDEYVRVFLPYESPISVLVCAGYLLHPRLANIVDIPHSNKQVLSELGSWMRTCKQLPIESDLGPAFCFHSCLTCPISKDQTCSLNPPVMLICGHVICSICVESFGNSRRKLEFKCPMCPRVMRPNETKQLFLDWNSCGLDEPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0R7</accession>
    <name>A0A061D0R7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0107050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766582.1">
        <property type="nucleotide sequence ID" value="XM_012911128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0R7"/>
    <dbReference type="STRING" id="5866.A0A061D0R7"/>
    <dbReference type="GeneID" id="24562937"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107050"/>
    <dbReference type="OMA" id="YEESFAY"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="861"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1138" mass="129265" checksum="D61607FBCA765B52" modified="2014-09-03" version="1">MDENYDEDEPEHMAAAEMEHLDADAGYVNDANAVDQSDPEIEGTYSRTSSVVDKLDDEDEFDDSKYASVVGQSGVEMKDEAPESSSDMEQADDESDRERSKLAADLAAPMVLGSGEYELDVDQQSQLAYNEERLLYERKRLSYTEDEGEQSFTDRSVDVSSRDQSPADMLRMSERHRDDTDDELYTRGEDQHAESPRSDQSVTPRNFDKTDDIMYGDQPSNADVAESSDDEQRDESPHTVSQVDRQKFEVIKGDSDDSRYSPNSSDSEEDFRADTPRPEKSTQSESLETDDRERQDSVQSDEPSGSETSKISAANSEAGAESTQGDSTPKLYNVSNKSSRKRSDNVTPGTSENPLDITDFIVDSGSLLQLYQNDYFDAYMHMHHLYYKKEAGVHEYLVNLLYSKRTDNEVMFYLPQLCQLSISKYGKSSLHRFLLDKASTSMHFALKLSWFYQAIISDQASKIGHLAQKMTQETEMAVVNSKLISPVATCLPPTEDRELNLCSKGLLIRRVIIRAIRAGHDSGFNTSTEVDLLDRPKLPSQLNNSAMVLTCATSKAKFHTPYAKIGNPLELDLHPYVDCPDSMQFELERLMLKQRRLDYFNMLSNFVKLCMDISKLLTTVSKRDARQPLLALFAKSMNEWMLMQRCTVAAYEESFAYKGLSLPMRKMGRDKRTGIPFQFLRIVEEETKIFLSKKRAPFVFYFEIANLDEDVRQISRSDDRNAITDATFRDLGVYVAIVKDLVSSGLLDVADVSCIQNPLDCIRYTMGMLPPDVLKRYEERKKEFKSGSIASWRGGDDEDASFLISSVHEMSLGAGSEYGDNSARSEHSPARSQSVVETKYPLISKMSAREAQAVIFPELLDDKKKRIRQYSPYGKLETWNVKAVIIKGGDDLRQEYMVNQLLTLFQQIFANAQLPLWLRPIEILVTGPNCGIIEFLHDTCSVDVVKRKFNVESIAKAFERIFADNLFEARKNFIESHAAYSVVSYLLQIRDRHNGNILLDSEGHVIHIDYGFCLSNTPGNISFETSPFKLTKEYVDVMGGETSDNFEYFKTLVIRGLLEARKYMDRIVLLVEMMTGAYKMPCFVAGTAYTLDMLRERFMLNLSEDVCIDRIMAMIDESLNNFTTVQYDNFQRLTNGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1M4</accession>
    <name>A0A061D1M4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0103415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766213.1">
        <property type="nucleotide sequence ID" value="XM_012910759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1M4"/>
    <dbReference type="STRING" id="5866.A0A061D1M4"/>
    <dbReference type="GeneID" id="24562568"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103415"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103415"/>
    <dbReference type="OMA" id="DYGYIQN"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14838">
        <property type="entry name" value="AP4_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="189"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="459" mass="50799" checksum="EED8FD684320BDD3" modified="2014-09-03" version="1">MALSHFFVISSCGDRLLLRSLRGEGAEGSVDEFYSAVTERGEDARPVFKLSDVLYYHVKRYGLYFVATTSFAVPPSFVFELINRIIAAFKDFCGTLSEESMRRNFVLAYEVLDEILDFGYVQCTNTSQLKQKVYNVAVMPATHSRPVVSLAPAFVKLRQVGMRSNALAYPMTLPSVVSQRPLAGGSTRGSEIFVDVVEKLSAVLGADETYRSVTVDGHIQVKSFLRGSPPVKLALNEGIVINSRRGKVPNVPVLDFCNLHQSVDTSEFEKSRVLSFTPMEGEFTLMTYRMSGSAVLPFKVKAAIELNKDSVVGAATQLTSMQASVTINVFCSINQNLDASVTLRCPVPRATSDATLSVMPPDAGTTSEYRASEHALLWTIKRFRGGTGMSFKAALNFAPQAASVSRREFGPINVAFEVPKYCVSNVHVRYMRVMQPQSSAQTYRWVRYITLSNSYLCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1N9</accession>
    <name>A0A061D1N9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with DnaJ domain, DNJ1/SIS1 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766233.1">
        <property type="nucleotide sequence ID" value="XM_012910779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1N9"/>
    <dbReference type="STRING" id="5866.A0A061D1N9"/>
    <dbReference type="GeneID" id="24562588"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103610"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="320" mass="35966" checksum="AA43ED149B8939A0" modified="2014-09-03" version="1">MGRDYYAILGVNRGCNEAELKKAYRKLAMQWHPDKHPDPAAKQKAEDMFKNVSEAYDVLSDPEKRKIYDQFGEEGLKGTAGPHDHSASHQYVYTGVDPTELFKKFFGADRGFMFNSGFGDDIGGFGETFGMHHGGRQRSHKSPNYELDLPVTLEELYTGTVKKMKITRKRFASGTEYKEEQILKIDIKPGWKDGTKLTFSGEGDQATPASPPGDLIFIIRAKKHARFMRDGNNLVYKFTVPLVKALTGFQATLTTLDNRRLTVRIVDVVSPTYRKVIANEGMPISKTPSERGDLVLEFEVTFPRTLTADQKKQITAVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1V8</accession>
    <name>A0A061D1V8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-like protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0104210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766298.1">
        <property type="nucleotide sequence ID" value="XM_012910844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1V8"/>
    <dbReference type="STRING" id="5866.A0A061D1V8"/>
    <dbReference type="GeneID" id="24562653"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104210"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="446"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="737" mass="81248" checksum="4A8BB75FD78C47FD" modified="2014-09-03" version="1">MANSGRDGKSDDGSSSPESKKKSFVKSMVKGGIFGGSRRPRAQTTDAEPKNDGKSEDVAPRDTVAADARDEQQKRAKFLAEKYEKIFAARNSAESKVARATQSSVSATTTGPSSAAAASRAAATSQASESAKSSVSAKVSAFSKASESTKSSVSAKVSVTPKPSESAKPSETAKVSLTPKPSESTKSSVSAKVSVTPKPSESAKPSETAKVSLTPKPSESAKPSESATVSVTPNESAIPQLVVTSVETSASKADAEKTESPSSGARIRTLADLQREENQGGHSSEHRASRARYQSSAGDQGVSRFWCFNRQINCPVRIEVRGRLFPGRLFLMISSTILMTVLFIYQAYLNMATFNGRCVGGADYSHKIENRGIFNPLGYTACENNLKTKASERHTIGLLTTDLGYPTDYVYKGYEGGMAGTADGPNVRTLYLMGAMSPNHVRLYKESYRIWTAIFLHSGYFHLLNNMLTNIVFLYILEPDWGFWRCLVAYLFCGYAANLVHASMSPCHATVGASGALFALCGALIPYAVEQWDKLRSPVFIILVSLVMFLLDGGYVFGLCYGFVTMETATLLDRGALFHRFVFRLFSSRMSEETQQQYRDKIAQGARSSELARIRYEQTARDRVDRYRFVKRLFGIYPLGRNRLRIRDIVLRVVFFVIMISMFVYFYVATYNENVYTKLSPQTNIFFGRNCYCGFLKKDPAEELLRYQIGDLGGQFMCFHRVKTRMEFCDPGDGFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D270</accession>
    <name>A0A061D270_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766899.1">
        <property type="nucleotide sequence ID" value="XM_012911445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D270"/>
    <dbReference type="GeneID" id="24563254"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110110"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7200" checksum="02AC9C2EA7C190BC" modified="2014-09-03" version="1">MPQSENFGADLPMDEPRKNNSDNQPKYDGAKSRFHRGCTTDHDRTKSAINAQNRDGRLPPKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2E3</accession>
    <name>A0A061D2E3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0110650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766954.1">
        <property type="nucleotide sequence ID" value="XM_012911500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2E3"/>
    <dbReference type="STRING" id="5866.A0A061D2E3"/>
    <dbReference type="GeneID" id="24563309"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110650"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF8">
        <property type="entry name" value="CYSTEINE DESULFURASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595697" description="cysteine desulfurase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="76"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="826" mass="91659" checksum="DB8139D91D1D0F91" modified="2014-09-03" version="1">MYTRGYIVCLVAFHIFSGALCLSPTGRLRTSFLHPPTRYNTLHGGRWRLKSDGAERDSPYVYEFPALNRPESRNLVYFDNAATTQKPRAVIEAILDYYSNPCANVHRSQHDLATSASTRYESARHNVSSFINASSPSEIVFTSGATESINIVAGSWWWVEKLHVPHRDNVGPGDVILLPLSEHNSNIIPWQLHANDSGCRIGFIKLTEDGSVDLDDYNRLLDQGNVKLVSLAHASNVIGRVQDLSTIVRLAHSRGAKVLVDACQTLGHIPIDVSSIGCDFLVGSAHKMYGPTGVGFLYAKRSILDSMRPHRGGGGMVKNVTTTRFELEDVPHRFESGTPQVAQVIGFSAAIDFLRDIGLSKIAAYERELLSYLRDQLCKVATVYSPALDPNSDEHCPIVSFNVDGVSAFDIAALLATHNIAVRAGQHCAHILHRDYLKVDHSLRVSLALYNTRGEIDDRRPFTHGVCTMTLTRSLARLKSRSPYLGFFRNTPFYRRSGGDSILRVNPRLVPSKQLGKTLLRIGTLGMDRAKLERILITCATQMGQALDDVNLSTCLSLMVRLQISNPQCLESLVPYCYRISDLERAIACCHLIGMVPGSRDSPSARAFVVHVSQRVPLEGHSLLLRDLGRLCESLRVLDLYCEDLGEFLASVIEDELIHSESSEDAVYITSVLGYLGRMGVGSVPLWRLFSRYTATEGIHSNPRVLIKALESFCDRRIKHESLLNQAGDALALVLDSLRPSEVARVADVYSRLGFYHKRLAEVLILGAERVTPFLDASDSVKLLRTFVQAYSQPGTHAAITQDPSLSHRHRRALYLTFNRCTTGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2N7</accession>
    <name>A0A061D2N7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0106360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766513.1">
        <property type="nucleotide sequence ID" value="XM_012911059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2N7"/>
    <dbReference type="STRING" id="5866.A0A061D2N7"/>
    <dbReference type="GeneID" id="24562868"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106360"/>
    <dbReference type="OMA" id="WKRIMKK"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="24817" checksum="4007B62B8744B719" modified="2014-09-03" version="1">MASRASANITEEPAGAPSCPIEGQFSDEKKLTKSSCSSSQTGDSVITLITKAEVKDLNATRTQSNIPGKNSNWIYPSERQFYRSTLAKGHRVDATVIPTVVQIHNAINEKAWERIMEYEDMHYDRCQKPVLAHFIGKKDQLTLRARLRHLMGYKLPYDRHDWTVDRCGKLVRYIIDFYEGRAPNDEPIAVYMDVRPELSMGGIVDRCRLWLKRNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D313</accession>
    <name>A0A061D313_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Elongation factor Tu GTP binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0203130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767342.1">
        <property type="nucleotide sequence ID" value="XM_012911888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D313"/>
    <dbReference type="STRING" id="5866.A0A061D313"/>
    <dbReference type="GeneID" id="24563697"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203130"/>
    <dbReference type="OMA" id="LMGHINH"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF5">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="642"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1165" mass="128608" checksum="9BC2C8B688AF652A" modified="2014-09-03" version="1">MFISAHARYLDFGGFGRDLLLISVLFATVTPAVSGIRHQACGHDSFWTPSSLGRCGFQRQLCTKDAYIPPPAYRNFVDQGWRGTTWEYGASADKEVRIHGLRSTPDGAAFGNVSFSAGPKFPSSQAYQAPIGQYSYSGYYVNEYDSGVRPHANRYAYRSFNDGTQGGYSYANMRNHAYGHPPFPGNSYQTQVSYDRAVGYGAYHSYPGYDRHRGPATRYGMQKWHSSSGFPNKRPYHPGMARFSPAADGRHAPFEATRDTRARGGVYGSENVREFSADDEKEQYGESGLTNREYFCSFRVYNQLTWMNDFTPHEEWPGVSKLKHGEVFNVMIRHWMTPVRAVALSLDKMAECCLVADGIPPELSTPTVKTHFKADKIVQVKLKWPQEFDDKGRPLVVMHFPNGDPPASYSAGDLAWSIPLMINGNQAIMKLEDSNHVALMYLCELGAPLIDNKRYGFADFLGKGERIQLQITHTPHHPDHITYRACVPWASPKRLEWARKFPEIKEMLAPCEYNRNFLNVIARSPAYRNMSFGNPEMPPSDYKPEPHGSNQKDIYSFLPTAEKPLSISEFTKSIGGKLKDVLRYLLLQTKSPVDPNTPIPVNLAKTIYNFVSGRTEFNDIDTYARAYEIDQLKEKSIVVSLERPPVVVLMGHINHGKTALFDMLTGTCNVEKEPGQITQMVRTHSLTGERAMTLIDTPGHEVFDAMRRCGATIADIALVVVDSTEGLMKQTRESINLCKQLGIPFIVAATKCDLPNARNRAEELALQLSEEGVVIEGLGGDIQFLQVSAKEDTDSAKQSIVDAIMLQAAASDDHVVTESPGTIGRGYILDSGKGNRTPPFCLAIVKQGKIAKDSYFVSGKTIAKIKGLKTHAGKRVTSAVPSQAILVEGFEDGILPTPGDSFVVYTDEESARVLTDDKIDTEREQVAATELQRIIYEGIDALAGRATEDTTVKRVPALVKGATQGLVDALKHALSALNVQGMMSTAVYEIVEATAGPIYQSDITSAYGANAVILALDSPLRVDAKSDAKKHNVTVVSSEVIYDLMEKARELLAQRLGDRLLTTPYGSARVLKVFDAAKVRLPSTEPYTALQNAKAAGCVVLKGRIPKNSAIRVLRNNRPVYAGKIASLRHTTDSTDEAVEAQSCGMTFEGWNDVQVNDVVEAYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3W3</accession>
    <name>A0A061D3W3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767592.1">
        <property type="nucleotide sequence ID" value="XM_012912138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3W3"/>
    <dbReference type="STRING" id="5866.A0A061D3W3"/>
    <dbReference type="GeneID" id="24563947"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205640"/>
    <dbReference type="OMA" id="PSMRIWP"/>
    <dbReference type="OrthoDB" id="365719at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54177" checksum="4E5245070A150E8C" modified="2014-09-03" version="1">MSPELGPRSFSLPALTTEPLPPREVLRRSSAREANVLRSDESSQTEPVVVETISQPSHIYKSQPVVATSAVAADSNLEDAEPPAVATTSTTDIITATTEPHVYVPLAHIKHSQQNISIYVVAVEMIRSNLRSVRTQADFLNYRAIDPSVYGTHEDQCIDYSVQILLPNASKHFHVNYGDIIRLRRVNAEFVTDKTGKKHVNIIMGLKNFPSMRIWPNEACRVNTERQDPAASEPVEEECDRKRRRTDDLKKLESEALVVYSGTQTRVDDVDLEMITKLRTWVRDTLDARELITNPEFARTIADAGPCGNDFVVCVLEVSPEPDVNLVVSDASSIALVMGMNDILVSNLLESHNRVQPGEWLKLRYVQRSVTPFKRADGSSHVVLTASKFSTVTRLPILNLPYVKPIPATSSRSKKSRRATRMKMWNEASGLNRQFPLRLRNTTGYVNRLLQFTCMEDGEFEKVTRVSDVEVEEGEIQPTVPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3X3</accession>
    <name>A0A061D3X3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765865.1">
        <property type="nucleotide sequence ID" value="XM_012910411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3X3"/>
    <dbReference type="STRING" id="5866.A0A061D3X3"/>
    <dbReference type="GeneID" id="24562220"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100080"/>
    <dbReference type="OMA" id="QVLWIAG"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="112" mass="12171" checksum="4D29DA5A7054D465" modified="2014-09-03" version="1">MIPIRPLARVLTQVLWIAGGSVVKATLRAYRESVANGAVAGTSILRRQMSPDEAAKILGLPSTAHLPLAEIEKAHQRLRNINMASSTFQGSPYLVERIDAAQHVLKEHLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D411</accession>
    <name>A0A061D411_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable fructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765900.1">
        <property type="nucleotide sequence ID" value="XM_012910446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D411"/>
    <dbReference type="STRING" id="5866.A0A061D411"/>
    <dbReference type="GeneID" id="24562255"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100430"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052700">
        <property type="entry name" value="Carb_kinase_PfkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320:SF3">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="5">
        <location>
            <begin position="95"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="397" mass="43676" checksum="7CF9A22641AAD71E" modified="2014-09-03" version="1">MRSITASAFKLCCTAALIFSKSYEHGNDHDVIEEGPSRLLFVGQAAIGLYVKYRPNGRRGEDFDISYTNESEEAFSSIGEKKGVDAINPDGPSVTTARTYAKLGGEAAYIGILGDDDLATRFEKAITADGVEDKTIRRDGETTTELHSLVTPDGERQTYKVFGAGGSISEEDIHVSVMNNFDYYVVSTNMLRSPGKLALTTKMVDATLNSGKQIITLLPTSDFEVRYKDALLNIVDKSAYVCGTKEEFARLYGINNISGLKLYFLKATSGDHPIHKAVIMMTEEFGTFLFYGGRFQYILPSTVLAVDTAGADDVFGGALLYGILNGYTVQQASKLAHAAVSDILTRIGITFSEELSTRFDEIKRLPSKKLEEEMQEKAWEDMTRSMGTPQLDTYESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D452</accession>
    <name>A0A061D452_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication factor C 38 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766998.1">
        <property type="nucleotide sequence ID" value="XM_012911544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D452"/>
    <dbReference type="STRING" id="5866.A0A061D452"/>
    <dbReference type="GeneID" id="24563353"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111100"/>
    <dbReference type="OMA" id="QCFELGT"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="363" mass="40339" checksum="80F8620ADF71CE83" modified="2014-09-03" version="1">MLWIDKHCPKQLYELNSHREVNELLTKLVEKSHGELPHLLFYGPSGAGKKTRIMATLRAVFGAAIDRVKTEVVSNVDTSNNVIVCQSDHHIHSESTVEQLHHRAVPCTELGSKDRVIIQDVIKNLSASPSASNYFLKGPAYRVFLFEDADSLSLPAQAALRRTMETYIRNARMFLHVKQLSRIILPLRSRCLCIRVGSHTIAEIVDVLRGIAKAEGLPPKQSSDEVLRSIANASGRNLRRAILTLETMALGGFPAAPGEFLMPWELQVAKLVKSVLENQSPSTISALRPQVYELLVCCIPGEVVLEKFVTMLSQRVKPELVPKLIHVAAHFSHTMQQGSRQIWHIEACIVQFMALLAGKGADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4G9</accession>
    <name>A0A061D4G9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0201040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767133.1">
        <property type="nucleotide sequence ID" value="XM_012911679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4G9"/>
    <dbReference type="STRING" id="5866.A0A061D4G9"/>
    <dbReference type="GeneID" id="24563488"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201040"/>
    <dbReference type="OMA" id="EGFKIKP"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="7">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="6">
        <location>
            <begin position="158"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="389"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="498" mass="55227" checksum="17EB12D885C7BE12" modified="2014-09-03" version="1">MPRKYTEVISEADGHRVMAQAAAEDGSSSLRYRTIGGVKGPLVILENVRCPKYAEMVNINLGDGTTRRGQVLEVRGNVAVVQVFEGTAGIDNRSCSVDMTGDVLKMGVSEDMLGRVFNGSGKPVDGGPRILADDYVDVNGEAINPMCRLHPREMLETGISTIDIMNSVVLGQKIPLFSAAGLPHNEIGAQICRQASLVDHKDVVDRHPDNFAVVFAAMGVNLETASFFKNDFEQNGAMSRVALFLNLANDPAVERIVTPRFAYTLAEYLAFDREMNVFVILTDMSAYADALREVSAAREEVPGRRGYPGYMYTDLASLYERAGRIQGCNGSITQFPILTMPNDDITHPIPDLTGYITEGQIFVDRNLYNRGIYPPINVLPSLSRLMKSGIGKGLTREDHPAVSDQLYSDYAIGQDTRTMKAVVGEEAMSSQDLLYLEFTDKFEQKFLKQGQYERRSITQSLDICWELLRTFPEDMLKKIKKDIIQKYYPRSHATASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D552</accession>
    <name>A0A061D552_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0203340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767363.1">
        <property type="nucleotide sequence ID" value="XM_012911909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D552"/>
    <dbReference type="GeneID" id="24563718"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203340"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="123" mass="13569" checksum="7F146C5370B372C3" modified="2014-09-03" version="1">MQGCGVTYELDELFKPETPKLYNAEGQEIGCKINLQAARKAAFYCPTPYAMDPPGCFNQFYVDGELNDLSEISKSLVPSRTNHFVTLKLNGNRVGPGEELRQSPPLECPCITIKGVVLSTIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D592</accession>
    <name>A0A061D592_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766325.1">
        <property type="nucleotide sequence ID" value="XM_012910871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D592"/>
    <dbReference type="GeneID" id="24562680"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104480"/>
    <dbReference type="OrthoDB" id="2192909at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="7114" checksum="43A266483063B4E1" modified="2014-09-03" version="1">MTWEGIVTKEHSKYRRDLGISDRMEAHIQRVVIQETHKIVMRDMKPREDYDSVEDPGAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D595</accession>
    <name>A0A061D595_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0208870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767919.1">
        <property type="nucleotide sequence ID" value="XM_012912465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D595"/>
    <dbReference type="STRING" id="5866.A0A061D595"/>
    <dbReference type="GeneID" id="24564274"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208870"/>
    <dbReference type="OrthoDB" id="162638at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.60:FF:000001">
        <property type="entry name" value="50S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_bL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_bL35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600617" description="50S ribosomal protein L35" evidence="5">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="142" mass="16123" checksum="85055D0D08E72EAC" modified="2014-09-03" version="1">MRSLPFLVAASVLVAQHQFGTTADAYRSSERNMRADTTLAAYIIYGGSIEPRKAARNVPLFARRPHKLKLTAAGQFRIKPKTNKSVAKRFKITGTGKIMYKRAGRSHLQRKKNQGAKRRLRRAVQLTNPKMIRKILSVLHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5I0</accession>
    <name>A0A061D5I0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0211280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768167.1">
        <property type="nucleotide sequence ID" value="XM_012912713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5I0"/>
    <dbReference type="STRING" id="5866.A0A061D5I0"/>
    <dbReference type="GeneID" id="24564522"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211280"/>
    <dbReference type="OMA" id="NEESWKH"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF8">
        <property type="entry name" value="PROTEIN HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="207" mass="24045" checksum="326B246E064753A8" modified="2014-09-03" version="1">MDRKEACSGLATGDVGSHSCPLDVNEANMMPVLPNRALEDAARGLDRTREQSSIPRADTGEKWTYPSPMQFYNALALKRKTSPDEAAYMREAVMAHNNVNERTWEKVLEWEKMHSSTCPNPQLRRFVGKYGHNSPRSLMHRYIWRMGEPFDRHDWFVNRCGREVRYIIDYYDDPRAQDDVQVYIDARPALDSFGAIMDRIKGLFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5L1</accession>
    <name>A0A061D5L1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768014.1">
        <property type="nucleotide sequence ID" value="XM_012912560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5L1"/>
    <dbReference type="STRING" id="5866.A0A061D5L1"/>
    <dbReference type="GeneID" id="24564369"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209810"/>
    <dbReference type="OMA" id="GYTVKCL"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="569"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="781" mass="84583" checksum="F5F9E63032E13570" modified="2014-09-03" version="1">MEAEEDFPRSSEVVLQPLGEPRRRSRAAAQQAQAPSLFARPQPKRSAKLADQRGRLPTLESLEAGSLVLGSVAVVAPTGLRIHLPGGLSGFVRSSDVVDGAQAAKSRPDHVTQGSFSVGSHVVCSVLEVKNGFAYLSMRPSVINKGLSLATITPGMLLPASLVAHEDHGILLSFNLAGADDVRGFAKYDDEQTAGTPAAASEDVDADDDAKDAAAEDAKSGKGVEASGGKQAAKTNGGKQAAKKGRSFDSLRSLPLGSTVYVVVDSVNVARKLVSCKWPWQCDVPVSTDCQLPILCVRPGLLLVGEISDIHYPASALSGNAEFKVNYGFDVKCLNGLTATVPAVHSVVSYSPRRPEDNTDDGEMESDDEKEADVDASTADGKSKVKRKSKTYALPGAESDSPLGLEDHVVGRVLYVNHWQKTVYVSLLSDIVNWKGPKGHPHQLIYSGRKTYGKVLRSIPGHGVVFALCRVRNDGQLARKGGPEALNYTYGDLGYCDPSNLCDEGKDDSDKSMGAKGTSAPQIALAFSSGSVHAAAELEFDYLTRFVRVSMRESLLTETALSPFQLRGGTSVKGVITKVSNSGVSVRLSKLVHGKVQLEHLTDVPLPHVPDNMVVGGTLKLRVLRYDHVHSVLLLTAKRSMRKDPAPLTSFQQTAVGKEFLGYIWRVKRTGEKDSKAKDKVDETVYVRFYNELQTTLDQSELREAELQGLDMSHGALVRAVVTRADARRRAFYVTVRHDKMASLKALARARSKRQREIRRAECKKVFTNYVSSRKRRKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5N2</accession>
    <name>A0A061D5N2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768222.1">
        <property type="nucleotide sequence ID" value="XM_012912768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5N2"/>
    <dbReference type="GeneID" id="24564577"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211780"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7646" checksum="9AC2BFB96E878FBD" modified="2014-09-03" version="1">MSSRNKTVRQKAVMPTFGLHFLQPRFMKSGHFLQGAPGHLALCLLRISVHKGHVSPFVTVPLQCLQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5R7</accession>
    <name>A0A061D5R7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0205050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767533.1">
        <property type="nucleotide sequence ID" value="XM_012912079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5R7"/>
    <dbReference type="STRING" id="5866.A0A061D5R7"/>
    <dbReference type="GeneID" id="24563888"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205050"/>
    <dbReference type="OMA" id="EFMMEIN"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="178"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="382"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="658" mass="73872" checksum="8C43FA48A0C5422E" modified="2014-09-03" version="1">MDDDNGNSIQNHEVLKEGADSEALNEFFKTLEEYEKDFEEDGSKFINNYVVNEVPEEDGSNNGDGYTHQDVLSQRSESSTNPNGQDNIAQSRPPYDIRTNIDCQNAVDIYKVDAEVNELTLIDIVNLKKRLGIETLGLRVPKPIGSFSHLTASVAAPLLKRLHKLGYSEPTPMQCQAMPILLQGRSAILMGESGCGKSLAYVLPLICHMLRLIRDTQAVAPMRSAFCIIMALTREVSNNIFTMLSKLMKSVVLRIAMISSGYDNYSQIVSGTEFLVVTPAKFGDLMNQHCLTLGATKYVVVEGFEKLYHKHPNEVETLLSHRCAIKVVLSNVILGVKTLAALRLYIKGAITVKYIIKHALSGANLKWIACLKEPSHVQKATFIGDLLSHFHQPFRMVVFANESTSVENICSYIQNVTGNVGFVHEAVEKDITAETLRRFSEGKLHVLVTTDTMLRYVNLPKVDYVVIYDMPRTLNKFCWNVGVASASEKSVVYSLITKHDHIICAHICNQLFDEGLELPRVLDQVALKWKPYRYSRCHRRESGDQERKHKEVEVMIRDPAQVGHAQERDAQGCVTSAVYGDVTKYAEAPGIQRCFETPASSGETQNYSGRCYNATDELPSDDDAEMPPKRQLKNASGLINLEKLKQRRLRMMEEQNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5V5</accession>
    <name>A0A061D5V5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase KIAA1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0205550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767583.1">
        <property type="nucleotide sequence ID" value="XM_012912129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5V5"/>
    <dbReference type="STRING" id="5866.A0A061D5V5"/>
    <dbReference type="GeneID" id="24563938"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205550"/>
    <dbReference type="OMA" id="VHEVYQQ"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="254" mass="28896" checksum="6BABE098C80A4AE1" modified="2014-09-03" version="1">MNDSSKSAASEDDKKCIPIDLTKEDRNTIESQYVHDLYEEIAPHFSHTRYNQWPGVLKYINAAESYSTVLDVGCGNGKYLQFRSDLLFIGVDRCSGLLKLAYDSKCPNVLRCDCLNLPFPSEVADLTLSIAVIHHLPSADQRRSAVTEMLRCTRSGGRLVVYVWAREQQKLTIGYRNFEGGDILVPWHMQKKYIKDRPIDGASTKTTGRATVYRFYHVFTREEVEELGASFNDVANVDSIEFEANNWILTLIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Z9</accession>
    <name>A0A061D5Z9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768322.1">
        <property type="nucleotide sequence ID" value="XM_012912868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Z9"/>
    <dbReference type="GeneID" id="24564677"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300410"/>
    <dbReference type="OMA" id="LWSWGTM"/>
    <dbReference type="OrthoDB" id="364799at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="601" mass="65737" checksum="D0DFF84B41FA2E25" modified="2014-09-03" version="1">MALHGSAPISSSLYLTKRARLSDALVKDRGFSEQGGVANDVTDLSHPSNRIQAKSGVTTSNEHEVHRGLVELARRRLKLASLDIHSDDSRTSICDGLSEGIKFLSQQRCLGDVSARMDFGYPVMSMPPKSSPLVGRVNDIAAMVNPDGSPRGKGTLSKRVAVGADYVETVVGPLSANEVAHILLLAQKLKETNQIDDTLERNIEMSANMWKQTGKVPNVVATAVVAGLYEGKAYQCATCGIRFSTYDARSRHSSSHEESRRDLLWSTLDEWISTPHLPSAVRSGQKVMMTLKGISNVLLKDTLSASPNLKWLREALFWRVGVENTTKDVEMESDAPIDKTDCIGGSSSEDRDESLQSLWSWGTMKDCHGTPAVNTYGGVVGTIGVESDVHIMLETCHKVKFNIARCKSNVPFPVNFADLTRKCCVICHDALEVKFNAAYNCYTYWDTACFKLDGDYIKRAFEDEQLSCKTLLATNGLSNMEDPFLILRKSAALTLVKSTLTTRRKKGLVGTSGREFVTTGSAAVPPERKTLWPDNQQLTGELVQKWNGPFAAASGAPGIPNSLMYAHSHCIKFILNAHIRRAKVLIDGNPCAQDIASISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D645</accession>
    <name>A0A061D645_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Actin I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0300760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm. Polymerizes into shorter and less stable actin filaments compared to ACT2/actin-2; this is thought to facilitate gliding motility and host cell invasion. Has ATPase activity. ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi. ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin. Plays an essential role during the asexual blood stage. At the segmented schizont stage, required for apicoplast migration and segregation into individual daughter merozoites. Also, required for the separation of daughter merozoites in the final stages of cytokinesis. Essential for merozoite invasion of, but not adhesion to or reorientation towards, host erythrocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer (G-actin). Oligomer (F-actin). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Unlike for mammalian monomeric actin, parasite monomeric actin is able to induce oligomerization in the presence of ATP or ADP. Mg(2+), which is used to coordinate ATP, is required for polymerization. Interacts with MyoA. Interacts with DNase I with low affinity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768357.1">
        <property type="nucleotide sequence ID" value="XM_012912903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D645"/>
    <dbReference type="STRING" id="5866.A0A061D645"/>
    <dbReference type="GeneID" id="24564712"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300760"/>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="422673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="376" mass="41838" checksum="C994793599E2E3D0" modified="2014-09-03" version="1">MSDEEPTALVIDNGSGNVKAGVAGDDAPRCVFPSIVGRPKNPALMVGMDEKDTYVGDEAQAKRGILTLKYPIEHGIVTNWEDMEKIWHHTFYNELRIAPEEHPVLLTEAPMNPKANREKMTTIMFETHNVPAMYVAIQAVLSLYSSGRTTGIVLDSGDGVTHTVPIYEGYALPHAIMRLDLAGRDLTEFMQKILAERGFAFTTTAEKEIVRDIKEKLCYIALDFEEEMNSAASSSEIEKSYELPDGNIITVGNERFRCPEVLFQPSFIGQEAAGIHTTTFNSIARCDVDIRKDLYANVVLSGGTTMYEGIGQRMTKELNALVPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQQMWITKEEFDESGPNIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D659</accession>
    <name>A0A061D659_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0206600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767688.1">
        <property type="nucleotide sequence ID" value="XM_012912234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D659"/>
    <dbReference type="STRING" id="5866.A0A061D659"/>
    <dbReference type="GeneID" id="24564043"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206600"/>
    <dbReference type="OMA" id="LPYCCLY"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="138"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="27450" checksum="A27D50E0F7953C59" modified="2014-09-03" version="1">MSRSWDQLKVFGQLLSVPLQRHVLGDEESAKLATLVNRAVTLLFKAYSNIGHDNVYVSFNGGKDSVAVLHLHRLASSFPDSGVAAGRPLNVVFFKDPAERLFPEITEFVDHVAKKYNFKVKVVEDVWHKGIPQIAAGRKAAFVLGCRSTDFEGSQISEIEEGSTGGVEFVRIHPLSQWSYGDVWNFLRLFSFDYCSLYDIGYTSVGSVDDTIANPHLKKPDGTYAPAYKLQNWSLERSGRTKTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D663</accession>
    <name>A0A061D663_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 8 protein HEAT repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766600.1">
        <property type="nucleotide sequence ID" value="XM_012911146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D663"/>
    <dbReference type="STRING" id="5866.A0A061D663"/>
    <dbReference type="GeneID" id="24562955"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107230"/>
    <dbReference type="OMA" id="HERRPQD"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058977">
        <property type="entry name" value="RESC8_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26172">
        <property type="entry name" value="RESC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 8 protein HEAT repeats" evidence="1">
        <location>
            <begin position="42"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="677" mass="75968" checksum="7ED20F6225DC6296" modified="2014-09-03" version="1">MSTVGRPIAAALTDAAKLVTRIKNAAKYGETDVDVWRKYSREVLDSAQTFDLAQVVNLLSSFSYMRYRHAGVLDALAARVCESSFKLKGTDIARVMRAYSVLEHRNEFMFRLMLPELSKRMDLFSLADLTSIFYSYANLGYYNRHFVACVESAVLNNIHNVSCKELCHALSALGKLHVRLPRLETVLGCHFCTRVDLCTYTELALITNALGRLDFCGHPHLFSVVETEVYRKSKNLPPHSFALMANAISRREDSSKALDFMSKQMPDRLREFDVHSLCLLSAAFSRRGAVRRELFDRMAARVGRISLALYPRAIASLSFSYGRAGHLHEPLMCFAGRHLERFVAHYSCNEVAMILRAHNMLTVRNEQLLLHLAKFICDNCPEIVPVRMADPLVRKRVAFAMGYDDESHEDEADVKAQSGSDFLAELFADTEDDDEDTNSSTSAPEGDSEITHINHLEVVVSDPFGTHRGGKHFLERGLMHSLLWIAQSFAVHGIWNEGDVKGAMQRIASEVATRVQELTPLTTVHFLYAYARLNYRLDTFLDVLLRELRNPRVNVIFEQDQLRTAFHALTAYGVDPASAGVYRLPSIEVKRLMEIHGNDVERVVRDILTTDYETTEGVKESIDLEIDVPFADSAAKAAIDGEPAITYVHIPACVGAALAAGRSPGSFAERVKYNFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6N7</accession>
    <name>A0A061D6N7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0301230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768404.1">
        <property type="nucleotide sequence ID" value="XM_012912950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6N7"/>
    <dbReference type="STRING" id="5866.A0A061D6N7"/>
    <dbReference type="GeneID" id="24564759"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301230"/>
    <dbReference type="OMA" id="CSWVVNQ"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="353" mass="39737" checksum="9319E342D3B7C67B" modified="2014-09-03" version="1">MIAYNTCSPPNFVSYCNDRLRSFLPVFLDIATAEIKSYDISDDDLAYYSNAIQYNLQGGKLIRGTLVVLTTRSLLGDGMTEHYWHEALVLGWCVELLQTAFLVADDIMDKSIMRRSNVCWYMVPTVGISNAVNDTMFLNTLVHRIIANQLKDSKHLVTVMNLFTEVSMITILGQHMDTYDAMDASVFDTPTGATSLYYRICKNKTAYYTFFLPMKLGMIISGIDQGNINYSKLESVSSLLGHLFQAQDDYLDCYSDPGCSGKEGTDIQTKKCTWLLATAIHVGDKSHLQTIKENIGKDNKDNVEVVKKIYNDLKLPHLFKVYTQDLKCNIQSQINDIGSKGRQLECAPLNAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6T2</accession>
    <name>A0A061D6T2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0303100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768592.1">
        <property type="nucleotide sequence ID" value="XM_012913138.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D6T2"/>
    <dbReference type="GeneID" id="24564947"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303100"/>
    <dbReference type="OMA" id="RIEYIIF"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="963"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1464"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="696"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1301"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1306"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2022" mass="228660" checksum="B22FD9BFD9F781A1" modified="2014-09-03" version="1">MADRFDDDIVAGSGAAKYGADGDVVREKAPAAAASTDEHIPAGLSHGERAQGADAISGMDYGSLGVLNVECVKSLGSDPDVPLKDRIRLWHAMCPTDFLNLLGSSGAKESCCVIHAESLIVHVVCSAEKEGNVLLDFAKGPQTLQLIYRVERILSQIVRCGGTFELVFFDVFKQLFDPTYCHAADGEDEEEQAQFFDGYLLLRELLLTHAKLNNIPHFVFRDWYDKDWIDHVNHCDPSCVLVEEGSSFLYKHRTVYELVDTTTTGELNEQNGEVVEEFQVQQRYIDRFTFAAHALVMHSLSMNVSVAYLFEIGPFAHNFKAFTSFPSNCTPPPALLEEVEAQFRAEYPYRSVQDGAAQDEEDAVVPELIEELAGLGVEPRLRQLVACNYLKSFTAMKQEAGDDLDEETALYIDSCLLTFKVLLLHNYLLDVLPLESRCTRRIDAENWEFFTTYVAATLDLMASTTVPVFNGIAKNLGKMGDSKRDVADLFDGNLFTSILHCMAVYAKDHGNKVDGAFISLDKDLSASMDKMYGHFSGNLNDTVFPIDLAPFADVGIYDCLEADSGVSDADNVDTDVLNVDNQFVNMYFGLNAFRDKVKFYNGDNSNLLTTFAGTNWRDPALVSEKLECIDYFFKVEKPDKFANMPKRTQRQEQRSMQRQTAFSHLLSRYMGSNNLHHPIVPKLDHPWLDVKQKALEESEQTKDEPTADARAGAKPGKKEKHGKEAKKEKAPKVKTSAKAELLKQKHTAAQESKGREADMKTLDRYSGRLVSLFSPEHDFDVIYTNILEHTAGPNRAVDLTDDFKWLKSVINTKAIQLQFVIKMIETLLRTFEGYRMRALNRRGARASLRRTICITLRLIHDCFKEYKTLIDGPGISLLQRFLIRLGMPVSARNLFEAWLKIHDDKKNKKFKVESEEAFDYAIPKGMEFEFQVAYMGDLMERTLGSTEDPRVLFKPDAWQKLLLDAVDARESALVVAPTSTGKTYICYYAMEQGLRLDDEGIVIYVSPNTALAIQVTYEITARFSSKNYTTHSCAAVLSATFLEKFHDPKWNCAQILVTVPAILEQLLISMRTSELGYAKRIEYIILDEIHCVSDEEIGPFLERIIHLSAAPFLALSATVGNPMQFHSWLSKVETVRMNTKNAKVHYIYFDERFSDLKLEFYSNKHLVPLNPATCLSYDNVKTSGFPKDLYLMPKDLMVLRRCTTAVMGNRCPDLDYLDPAVYFSGTPMITKRQYRYWLQTYITEFTRQVQSGVIGEDDFRNIMDNLKSVNTSVSPADAKAAVDDTTEGIFRLYPSLKPLQPKHSVGSNASDANGDANAESSSRSQGSALQSSITESRDYLDPAESLALLDTLEQTKRLPCLGFTFDRNHMEHMLISMTQLLKRRQWEKYYGTPEARAWTNAENKRRMDHYQMLMRQYEAETKMRGASREQKEEQGIGGKVEEFIELPEEPVDVAEDYDPEFNYYNRKIYVNYTEEVENFIKIAAASISGRKNVDIFIEAMRRGIGIHHEGLPHKFTMLTETLFRMGFLRVLLSGRSLAFGINVPCKSVVFMGDNHELNPLMYKQMSGRCGRRGFDLSGHVIFWGIPMKRVRQLLTAQLANLCGYASCSPTESLATLSAFNSLLVSVRSRPPQQHSKGKISTTDARVRKNEVIARSRDAVVNPRTVVKRLASIFMHPLKPQSDFSDDEVLIFRACVETLFKLGFIDSNGLVRGCCELAMLTREAHPTNLFVAHLAQRGKLHELAGRGEADSADKLMDIISKFAYKRKQLGTTITLRRLLPQRVRCGDRYTAKLVSNLDVRNKEGSVGVELLYPDSFPLLPATAGELRKMIDEYNAMVLGVLSKYQAHLKPMEAKLPLSNVDFRCTSQDAPSWFTERRRGMQFSSLYSPFVAINGIKGRFNTARELWLGTRASSEITLDMVPTIESFEIDVVQLDPHYNVLKQLAMSLDNSYVIDYWSHGRFSLARDANGLGQYAWFHLRKIVILLRQMKLTLNAYTNGGTWEDPLQLAVEEALDRYETAFNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6U7</accession>
    <name>A0A061D6U7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0303250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768607.1">
        <property type="nucleotide sequence ID" value="XM_012913153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6U7"/>
    <dbReference type="GeneID" id="24564962"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303250"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="90" mass="10264" checksum="2EB99E5E7D2B1BD8" modified="2014-09-03" version="1">MENWAFIRLMSICYLVAGALLTVGIQVTLRGRVKESERKDFYVLVLLLVPLGTFCLWLLWICMYMAQMNPMISPIKHVHEPAAEAVKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6V3</accession>
    <name>A0A061D6V3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0208860</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767918.1">
        <property type="nucleotide sequence ID" value="XM_012912464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6V3"/>
    <dbReference type="STRING" id="5866.A0A061D6V3"/>
    <dbReference type="GeneID" id="24564273"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208860"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="333"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="619"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR95732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="873" mass="97979" checksum="8ECE2D54ACD82B8B" modified="2014-09-03" version="1">MSLQMGFVKKLEIRKEKVKCVDLHPSEPWVVSGLYSGTCTIYNFQKQTLVKRVEVCNSPVRCCKFIARKQWLIAAGDEMCIWVYNYNSLEKVAAVEGHTDYVRYLDVHPTLPYVLSCSDDMTVSLWDFERGWERLCVYEGHQHYVMMARWSPKDVYTFASCSLDHTIKFWGVSPDVMDRRHSNQPSPKPSFTLKGHTRGVNCIEFSTIMSNPYIISGGEDTTIRVWDYQTKLCLQVLNHHTQPVTCVLHHPRLPLIVTAGEDGDLNLWHSSLYKIKRSMNFSMGKIWSVTSDNSNLAVGSDEGTLVVQFGGERPLVSMHANKLVMVHSFDIVSCNLSSATVVDEDSAGKPLALDFRNIGRCEFFPQSVSHHPNGRFICLCGDSEYVIYTAQGMRSKTFGKAMHVVWSFEGHYATWDGNTITVHYEFAPTHTIQPNVSVLGLHGGRLLGVTSNSSVRFYDWKTGYLVRTIDAHVSDVWWNVSGTKVAVGCMANCYILKYDSDALAAAIESNEYDAANGVAAAFEIEGEIMERVNSATWAMDTFVYITAGLHLNLWTAGASEIFHYLDRPLHMVGYSAQNGCLYLCQQDVVAIPLPVDYLSLHSLVASKAEAMAQGRAFADLDRLDALIGGFEGSMKERASKFLESVGDFELALRTSGEEEHHFELYLKLGKLDDCIRILHELQAKQVEKSREDTMRAKWKRLSTYCLEQNDYEKAVDCLVRCCEYSSAMLIYVAMGDRDGLAKIAELATKDGESNVAFTCHYMLNNVSQCIELLQRSNRHSEATLMARTYKPSALSDCFAKWKSSHNPKFPTLGEPEEDPAALEIESLLAERLRIGFPAASEYPKLKEAVHVDFGRGDDSVDKGALSSSWEAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6X7</accession>
    <name>A0A061D6X7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Patatin-like phospholipase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0301870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768469.1">
        <property type="nucleotide sequence ID" value="XM_012913015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6X7"/>
    <dbReference type="STRING" id="5866.A0A061D6X7"/>
    <dbReference type="GeneID" id="24564824"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301870"/>
    <dbReference type="OMA" id="MCNINME"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596028" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="817"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="821"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="853"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="855"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135479" checksum="43C3F9B7995BC11C" modified="2014-09-03" version="1">MWPIHAKLSLYILLTCLGMWSGKQTLQGARFLPGYLFAASKKANAQGFVVAATGGINAAAQDNGHSIGPGDDRHGKSSKKNILGRRRRCDTDSLLNCNPCGDTIVADTASDLAAPVSKSSTADSTVLGFIQELLARIGSTKGPPKQHVALNALRVLIESQPACINSLERLNIIDTFVSVLKQRYQRSFWSVLQSYFRSNSRLEEMQWKAMETTLLTILLTICRSNVKLRSVMAKNERFKSLLLTMYNHNKKKDDKNTNLAKKHGKRSSAKSNSELETDAEDAYQIPVARYDTSPYNMRDAAWLAASGERSGAMDVLSLQTRGLIRELMFMCGIDVESQNLKQQGASAKAKPAARQLVAVPVDTSVPIDAPAQGTNLPNQWQLPVPPMLLESSDGWWKGKAGQPKPRLLWIPYFYVPKNTKVEDAVKRHLLINLGDSAGEKVDLTNLLNVTIEHPRNKAANVVYGMLLLCKEGSDKSNGGCSLYTQTSSAKHKGNYVLISNIQVGKSKEINGSVVAGNLLKNMQRNESLKTITRVVNELWALVGSKDPDVLNELFRDLDFEFLAEVLNRSLVYTVRSDVFEQVSSNIETPSNGSGAYAMLQKLRRTVEGCLHKVMPKLRDSFWDKIFERSTDTMPATEQETTPSPENVLNNIRPCKKEADIARRLQTVVLGFLIDLIYMDGSRSLNKIRRATPLVDAVLRLRATFPAVHTLTEALDNELEDFAPLIDRRRNDARHTTNVIYKYIDRLSADDLTNMRSRKRDNFGNITTKASDWCKESWTRQKTIPRAIIGPFFNAHKLLNMLGHHEQDIFKGRGLRVLSIDGGGTKGVVVLEILEQIEKLLGRPLHEVFDFICGTSCGGIIGALLALEKGSIADIRRVFEDFMVKVFNKDSYHVTGRRLITRHAYYDEKMLYDSLRSVFGNAELIDYSVDPAAPKFCCLSAQLDVFPLNPIVWRNYNYPPDTVPGEENPMRDGSCAIMTADALRATTAAPTYFPLMERNGALYGDGALYANNPSLVALLEARLVYPNVPIDLLVSVGSGDWEREDIAQLSQNYVADKSKKTSAVESGCFRAEFSDGEDEVIAEAPLEEEQMLVTDASDCLLRSVNRPTNGKNKSVVGYHKIFNHLVCSATNTDTVHTALQALMSKKNYVRLNPVVPVVRIDDTNKEVLDDLKARTKTYMSGDLQQQALQRIKEAITHTHDWQRVAPEQHSTQTTQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Y4</accession>
    <name>A0A061D6Y4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L13,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0209110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767943.1">
        <property type="nucleotide sequence ID" value="XM_012912489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Y4"/>
    <dbReference type="STRING" id="5866.A0A061D6Y4"/>
    <dbReference type="GeneID" id="24564298"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209110"/>
    <dbReference type="OMA" id="SNVQWKS"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF41">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L13, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="27145" checksum="0BBAE9FD5359260E" modified="2014-09-03" version="1">MRLCSWLLARSLRQGFHESPVNPFAKVQWVSTPFLKKNMPTVSPLATPHRSLGVVTVMDTPTGHWHVIDADGKTVGGVASHIAVLLQGKHLPTYDSTRVSGDNVIVVNAVRVVMNGHSWDTKVYKFDRKAHPKGPKIITAKTVMARNPAMISPDPTQINMAVKRMLPRNKLRPLWYRRLFVYGGAIHPHWDIPQVVVPVSQSALDADTGSGSVAAPKPTGDPSATDLVSHRPAKAQPSVFGCYTLYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Y7</accession>
    <name>A0A061D6Y7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768657.1">
        <property type="nucleotide sequence ID" value="XM_012913203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Y7"/>
    <dbReference type="GeneID" id="24565012"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303750"/>
    <dbReference type="OMA" id="CLHIDIL"/>
    <dbReference type="OrthoDB" id="365908at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="526" mass="58178" checksum="7336D86FF9C663B7" modified="2014-09-03" version="1">MRGSHAVNLRRVLSLPTARRETFLFGRARARPRATRSGLAKPIRREGAPGTVITPSSLGNGVSNDTDYDTQSAWYGAPAPTGGRAALVPQSPQSADGKVSDSIAGRINASFDRSDIAYSASNLMEGRQSPLSVEAVLDLQIRQNVFNLPAPRLRVWLYNLDIGTIAQAALSNLFSATPSVDKVLVAESVLANKVGSEHGVRSCRDAFLLLKLQRALLLLGLRCELNLALYRPCIQLLNFKLDSMRSEHVVHVCQTLAWLWHRMALDGKLESIRDCHGLKEADDLQASLYSPLVSCLERAVLDIGPDTITRLLDLLVMLQRQLSKGKLMSSERVESNLPKPFYFVCKEVLAKLSKSVDYKDFHLVVRCLSRCSSVDPVSLNCVLLLYKSLATGSESSMYYPLERFVVEVILRGLEIEPVTKDANAELRRTQTEAASTYQAALTPLPSCYITVPKGYRRKVHSLKDISPLISWAVGTLKRSMDPSVADMCDYSHIKRHYRMRSSLQLPLTDLLRSSADRNNSAPATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7G3</accession>
    <name>A0A061D7G3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767000.1">
        <property type="nucleotide sequence ID" value="XM_012911546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7G3"/>
    <dbReference type="GeneID" id="24563355"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111120"/>
    <dbReference type="OMA" id="NLQCVAH"/>
    <dbReference type="OrthoDB" id="416353at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="472" mass="53244" checksum="71CF7BE89C6736E8" modified="2014-09-03" version="1">MFTLTNRRFSSAGLDVFISGVSRYRLLSASDKRKLLEAHRHKVRLALRGDMCVQSLPEAALKDAEKALDLRSEHAASPSPASATSAPSEQPTAAAASHRIAAELKRLKGRLPGSGRFHERNQPIGVGVSKFFMGVDPNTPLEPYDITSPLFDAERETETLVSDVKKAAAYDDVQSMLSALRPVRQDTLTDRFKDVMSRAIERNVARLERPVLFNELSDFESSYAMHRAALRNLLVNRCTRNAFEETRIERFLDRLKISDQRLDAPLPPEAVEPLMAFQGYCSYSFDPCVRLEQKLDNLQQLASATFDPSHSAGDESFLKRLGTPEEHPVGPPSKYPFKNYFAFDSCIPNDVTGSIRMGKRRASPSIRYPNLQSVAHSLPADRKYRAVVSNAIRVLERSKGWDHASKVKAINRLVQVYNNLAPSRYYSRVLDKAIPSVRAKGSVVRTRSRQETFNRGLHYIQSLTRNHWMKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7G4</accession>
    <name>A0A061D7G4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0210720</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768108.1">
        <property type="nucleotide sequence ID" value="XM_012912654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7G4"/>
    <dbReference type="STRING" id="5866.A0A061D7G4"/>
    <dbReference type="GeneID" id="24564463"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210720"/>
    <dbReference type="OMA" id="FVPCEHT"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="191"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="346"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="642"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR95922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="820" mass="91483" checksum="3CCE6475A94EE573" modified="2014-09-03" version="1">MVTPAQQIAQLAQGLALKPPRKNAAVHKAECIYSTDTEKSPDGLYINLKSFESFGKELLRFDRNAKGALYLHVVRRLVPRKPEAITENDSSANEEAVNHEASGDGVADDAGMSQEKEAVYVAGGSELMRFSFKQRKTCDEVVDYRVYAPSIQVSIPLDEAPDNVAAVCNAIIDHSGFNFSADDFVWKDYVTESKYAKHLIQVEAPPKINYENPQCERCGARTNLWLNLSDGYIGCGRKNYDAGGCSDGDEGAAIQHYQATGGVFPLAVKIGTITASSGDVYSYAPDEDTQVVDPYLADHLAHFGIDVKQLKETEKSTLQLEIEKNEKHDWSEMNSESHVVHGAGLVGLDNLGNSCYLNSAMQMLASVPDLASYFCEHYDSIATRVPDTVKPCDDVLIQFAKTVKAMTTSRVVDQQLELIRRYRTACEDEHVDFVEPEQYKNFAVKPSMLKYAIGIKNKSFATNDQQDAEEFFSYFLNVLADMEPEINRRAKTPCKIKKMFFFQYRQYIVCEALNKITYNDNEMHMLCLPLITGGMSQEDIDPNQPINIMDCFNYWEQEQEIDYLDKGQHHTGIITNALLTLPKYLVVKLNRFYFKADGTSEKITNNVVIPSEGITLETQGERPRGGYTVECNTREVKKAKKQMNPELLQTLMAMGFTEKLCRLAGEHADSHNVDACVNWILANMDTVSQDTATGENDASELAVNASVLMDLGYSLEQANRAAERFGSDVAAAVDWLATAELTVQATVKDKGKYQLLSVISHVGSKINTGHYVCHVNKNGQWYTFNDSKVLKYDMPSTGNGYLYLFKRSDDNKAASSVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H9</accession>
    <name>A0A061D7H9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0305650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768847.1">
        <property type="nucleotide sequence ID" value="XM_012913393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7H9"/>
    <dbReference type="STRING" id="5866.A0A061D7H9"/>
    <dbReference type="GeneID" id="24565202"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305650"/>
    <dbReference type="OMA" id="QFQMITE"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="858"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="931" mass="106595" checksum="367DBCB0E8F76999" modified="2014-09-03" version="1">MGIFRSETMSHGTLVIPQERARDCIDLLCRHTNIQFVDMNERCMERPYKKYLQRILNMQRMIRVLQEEITALPGTFIVKNKIDDFLQCDDVYRLDQVEESLFKLYGQFEKFKSNDLMLRTELEEVLNEYSVMLVALKQLNSSNGQSYLSAESPAQRGPGTDESAESNAKLLAESDANGDVVDREMVDIPSSIETDIQSATLAFSNIAGIISAHDKDAFSRAIFRAMRGNVYTFFQDSQVIREVMLARGLISEEEAAGHDKDEKIVFVIYCQSSSSSSTFQKLQKLCNGFQAKLFDWSKSQSHIRQRLGELEEIIRDKQKALNAFKKYFREEIACLLECPRPEGNSVVEEWALFCKKEKYIYYILNHFEASDITLRADCWFPEEEEENIRSYLLAEKSQGRVSALLLVDNQCKNKRLFDDPETMPPTYNKGGTFTQAFQNVVDTYGIPRYKEMNPAPFTIITFPFLFGIMFGDIGHGMCVLLFGLFLLIRHRKLKETYNGEIALMVINGRYMILLMGIMATYTGFIYNDFLSLPNNIFGSCWLSNPSSRVKVGEGQYLETLQRSSESFPVGFGLDVAWIHATNEQTMLHSFKMKFSVIVGFLQMIMGVCLKGLNAIYFRQPLDFFFEFLPQFVMMCCFVGYMNFLIIHKWITPLNNGFAKPSIITTMIDMCLMKDLTKDDIMYEGQQNVQRVLVILMLICIPMMFFPKPIMLYLAQRRRLVIGGGEPKREHELVYRQSDDIEARDQAVGGSSNTDANGMSESKFQFKRVSSTSEMQPGEFAVTIHSDGTVTEDHGSHGQHNIADIFIHQLIETIEFSLGVISNTSSYLRLWALSLSHQQLSSVFFKQTIYRSLEGEGGVIATVISLFITSIAFAVITFFVMLCMDSLECYLHALRLQWVEFQNKFFKADGKAFKPFNMKMLLESTDEEPSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Q5</accession>
    <name>A0A061D7Q5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division cycle protein 123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768907.1">
        <property type="nucleotide sequence ID" value="XM_012913453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Q5"/>
    <dbReference type="STRING" id="5866.A0A061D7Q5"/>
    <dbReference type="GeneID" id="24565262"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306250"/>
    <dbReference type="OMA" id="HKLYSFC"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="532" mass="59094" checksum="9BB5CF8C2FD5A8DE" modified="2014-09-03" version="1">MESLLIDYPLRPIFITGLWQCLGGHLRVKTSRGVGIEPTRLRNVLEVTKTANLSTTSTSIGSTSTNADAFITNHLTGDVKFLLFADGLARPDKGVQTVEGFHLSLIRASVTYNNEDGILEVVPTEATQMPPCPAGVTAWKHYSTYAEGMDNGSFTVESHCKEHMKRLLREYAFNEEKGSSMVAPQIGALDAVLYVLWNWVSESGEKAIGSHMYIMNNDEGVCFSHENVKRNFGSMLIPNSLQILEGSLLDYLKSDNMSMPPNIDQIKYKDVDSGSDFDGYESMSDSDDSFDWSAVEPFVEKLKALIAKYQSVVPSINGVFLDDALWVANMNVECTSAREVLLLLKSSTCWQDLEGSQCHLTLYPGIYFRGRLQLRCFLFENELVCVEQIFVNENFGFLAKDAQSLVGSLKSYSPSVMGVLNKGGVRSAIFDVTVSTKNGEIEMLNIYQFGSLPDGLLQLEDVYHFYYTGKSDGLKPLDLADMAVVDGVLVVFVGANSSRLQKHAWCPNDIGNLSFNTHDDLIDYLRFQAQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7V0</accession>
    <name>A0A061D7V0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosome subunit biogenesis protein NIP7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0201460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767175.1">
        <property type="nucleotide sequence ID" value="XM_012911721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7V0"/>
    <dbReference type="STRING" id="5866.A0A061D7V0"/>
    <dbReference type="GeneID" id="24563530"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201460"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="97"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="180" mass="20129" checksum="A9264725BFEF90EE" modified="2014-09-03" version="1">MRPLSEDEAQLVFKKLATYIGEKVLSLVDAGDSGPQHVLRLHRERVYYMNEAILKYSGCINHKNLISAGVCLGKFTKAKHFRLHITALHYMAHYSKSKVWLKSGEQSFVYGNNVAKKHIGQMSEDVPQNGGVVVMYNNLPLGFGVTSKSTEALKTALPDDVAVFHQADIGEYLRHEAEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7W6</accession>
    <name>A0A061D7W6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768278.1">
        <property type="nucleotide sequence ID" value="XM_012912824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7W6"/>
    <dbReference type="GeneID" id="24564633"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212340"/>
    <dbReference type="OrthoDB" id="365890at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="121" mass="14042" checksum="C8571003915061C3" modified="2014-09-03" version="1">MTTFYQYGFTFGDAKTLYGTNRKFCLSFHTQLSNLLKSQYFTKLFEECDNFIWTIREPFTYLVLALWSLSLFYLICVMVGRLDVLHIKSHLRSPSSHRITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7X3</accession>
    <name>A0A061D7X3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767205.1">
        <property type="nucleotide sequence ID" value="XM_012911751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7X3"/>
    <dbReference type="GeneID" id="24563560"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201760"/>
    <dbReference type="OMA" id="TYFQDQG"/>
    <dbReference type="OrthoDB" id="365269at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596070" evidence="1">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="302" mass="33004" checksum="A803AF58E997EC72" modified="2014-09-03" version="1">MQAFQAFAAAVCLLAQYVAAVAHNARNNPSPPELSAPSHGPTAAVNTAQLHNVKLPNTGSVLPSHSNFLSTIFQWISGEPETKVRNFTENVHSAAVEFTNIHRNKSIKKPFIEIQKSVAAYSDDQQRALVHFTLGHDTKAQSAHVTSAKLTLKRLSGGDEFGAECPNKKIKITRIHPPEGEGANEPKTVGNTYTADVTDSDVTCDLTPMFTADVAPADYHDFWLMLESEPLCYFTFDGKSTNAYVALVVNKSVTEVQQYKNSMMTPLALLGLVGVGTTIYLCTKNQTDYTYFQDQGEFIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8B4</accession>
    <name>A0A061D8B4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0308350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769117.1">
        <property type="nucleotide sequence ID" value="XM_012913663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8B4"/>
    <dbReference type="STRING" id="5866.A0A061D8B4"/>
    <dbReference type="GeneID" id="24565472"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308350"/>
    <dbReference type="OMA" id="YWMQETS"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="6">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="109" mass="12475" checksum="AE6BEFB5B5290C79" modified="2014-09-03" version="1">MDSDDGVVCQIRAGKCILEGNTARPDLRKGTLRLHRRDCDQVEDTFYVFEDALLERVDECKDGEVYALRFTGNDHKVMYWMQETSLDVIEAFVDTVNTAIGYKAMDTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8C9</accession>
    <name>A0A061D8C9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0301360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768418.1">
        <property type="nucleotide sequence ID" value="XM_012912964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8C9"/>
    <dbReference type="STRING" id="5866.A0A061D8C9"/>
    <dbReference type="GeneID" id="24564773"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301360"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="32"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="25007" checksum="19551E044CFBD019" modified="2014-09-03" version="1">MTADVALFRKWPYDSVSLSDLSLVDCIAIQGKARVFTPHTAGRYQKKRFRKTLCPIVERLVNSMMMHGRYLKNDDINSSNELFKRCNRFSPLSDFKLSNNGKKLKAIRIVMHAFEIIHLMTDQNPIQVFVDAVKNGGPREDSTRIGSAGVVRRQAVDVSPLRRVNQAIYLICTGARNAAFRNIKTIAECLADEIMNCAKESPSSYAIKKKDEIERVAKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8P3</accession>
    <name>A0A061D8P3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0308070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769089.1">
        <property type="nucleotide sequence ID" value="XM_012913635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8P3"/>
    <dbReference type="STRING" id="5866.A0A061D8P3"/>
    <dbReference type="GeneID" id="24565444"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308070"/>
    <dbReference type="OMA" id="NNKMMAH"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="159" mass="17246" checksum="6830087065AA3FBB" modified="2014-09-03" version="1">MAGKNTRMQQWLQYRVRVTIKDGRKFVGTFIAFDKHMNIVLADCEEFRITRGKGPDKKKVEIKRTLGFIMMRGENIISFTAEAPPAAPMVPYAMGGPGKATPAGRGTPIGVPRPGQPGMPHLPPGAMPLQAPMRGLVGPAPMQMAPQQGPMGTMPPRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Q5</accession>
    <name>A0A061D8Q5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abhydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769104.1">
        <property type="nucleotide sequence ID" value="XM_012913650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Q5"/>
    <dbReference type="STRING" id="5866.A0A061D8Q5"/>
    <dbReference type="GeneID" id="24565459"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308220"/>
    <dbReference type="OMA" id="FQPNSKH"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF197">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_38, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="419" mass="45948" checksum="C80A673DD88C5500" modified="2014-09-03" version="1">MGNALLLANTFIFPAPPASYTSQLYELIWIPKRFAFDTHSGRAAAPGSFPVLYLPSPAPSNVVMIYLHGNSCDIGQVKPELRLISHELNATIMAVEYPGYGVSPEVAVATGELINFRVRATVNFLISLGVDPRSIVLFGRSIGTGPAAAIAAEFKKRGVQCGGVVLQSPYISIHKIVEDYFTLGTWLVSNFWDTEKALRDMAPTTPLLIIHGLVDEIVPVAHGQTLFESYSSDLKMADFQPASKHNMYSIIEDVCVPIEKFLTTLSLSKDAPVVNLKLPQWCLYSCHKLVSGQTLMERNRKAGMAANQEKQICSARTHERRGRPQLVRNYSMNDGVRPHGKEDDLVPDDGGLVIARKIEAGSVSARSAPATEGAPRQVNRTTSKTSFQSSLQYLQEQNDINSDEISEIVNDAIARTTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8W1</accession>
    <name>A0A061D8W1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767495.1">
        <property type="nucleotide sequence ID" value="XM_012912041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8W1"/>
    <dbReference type="GeneID" id="24563850"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204670"/>
    <dbReference type="OMA" id="ENERKPH"/>
    <dbReference type="OrthoDB" id="428964at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30710" checksum="DF1C37A2B5E3F706" modified="2014-09-03" version="1">MLVLPLALRRRGLPLSRRWFTKLSDSSELRHGAAEEGLASPRDAVAEVTLSPLHTQRVGMFVEPGVLFKEHHRRRFLTFRLYFFSIVSLTVILGMIKIVPPGYVGLIVRRDGSIDQFNNEGRIALFYVPFLETPVALRTTPIRKKIIERFTTKDGKQVEAVIFLDLQAKLAYASHVYAVFGVNFSKGFVEKELLFDIEQVVKKFNREELLVQSDEVERLFASNGQRVATLKSHGATEEIVERFQDAGAFHKILVNNINVSFRDPSLVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Y7</accession>
    <name>A0A061D8Y7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766386.1">
        <property type="nucleotide sequence ID" value="XM_012910932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Y7"/>
    <dbReference type="STRING" id="5866.A0A061D8Y7"/>
    <dbReference type="GeneID" id="24562741"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105090"/>
    <dbReference type="OMA" id="NDTRYVW"/>
    <dbReference type="OrthoDB" id="365988at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="311" mass="35589" checksum="0791083529F5C633" modified="2014-09-03" version="1">MASLHDVRMSPKVMVPEYNFPIDYLKPTATAEQLDSLYFRERDGPTQVQPELGENIVYELCQLDASLEELFREGNADFTTHQQIHKFRLRVSRRISAFGGILRKLLLHSEESASANSLKFQSLHRFYVGRLMRHKNKLSGWWSRNERRYHTMCLSSFVSQAGAATELATEQDDVGDMCISSGVEGDESEVVLQLKATRNMMLNQISQMSATESSMLKSSNYIVRQEKILSALKQRFGSATRLLGSLRRKTLNRYGTVRLCYFTFLGMCLFIILRRFRVFKLAFNVSCVTYVLTFSVNEILHSCAAIFIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D900</accession>
    <name>A0A061D900_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0105190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766396.1">
        <property type="nucleotide sequence ID" value="XM_012910942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D900"/>
    <dbReference type="STRING" id="5866.A0A061D900"/>
    <dbReference type="GeneID" id="24562751"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105190"/>
    <dbReference type="OrthoDB" id="365867at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595583" description="Copper transport protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="319" mass="34438" checksum="8F81E8D29ED64AC3" modified="2014-09-03" version="1">MGGILRTLYAACIAHILFFCSESSGIITQKTNSLDLETATENGVALLPHLVTGDANGTKNPMLTTLREELHDSVTVTLDSSMKMVPSAHCSGKEVEECDPSRENCASKVENNNGTDIPLVLSATGYSCDGNKQQLHSDKGAGSVICNLKNKALPLAARGYQGRACCVTNANNLKDTTCRDAGASCGMAAYFENSCQATILFHFWRTTTVLNYTVTLIIIFLLSLFTVMLKALRKKANTALTNMNTCPYVLRQLAMFVIAYAVILMDFCMMLVVMTFNVGIVLVACTGYALGYLLTCFRPTSSTNVAESESPIECDADCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D918</accession>
    <name>A0A061D918_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0309460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769229.1">
        <property type="nucleotide sequence ID" value="XM_012913775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D918"/>
    <dbReference type="STRING" id="5866.A0A061D918"/>
    <dbReference type="GeneID" id="24565584"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309460"/>
    <dbReference type="OMA" id="MNIVKDY"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="349" mass="37888" checksum="C0C670B8E09305FA" modified="2014-09-03" version="1">MSSQKDDPASRLKALERMGVVKDYSRVYRSTVLVVGVGGVGAVVAEMLTRCGVGKLILFDYDDVELANMNRLFYTPKQVGMSKVEAAKQTLNAINPQVQVDAVHANICKDYSTFYERICSGALGGGQVDLVLSCVDNYAARVTINKACCQANQIWMNSGVAENATSGQIQTCIPGMTGCFLCAPPYIVAVKGDESTIKRPDVCTASLPTTMGVVAGLLAHNALKHILQFGNVTKLLTYNSLQDYFPSYSIGCNPECNENYCLQRQEEKRAEREKALEEERAAAEATSSAYEPVEHESNEYEIAVVSEDELQDVKATGTAAAEAKPSQAPAEKLSLKELRERLRNVSTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D975</accession>
    <name>A0A061D975_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0206170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767645.1">
        <property type="nucleotide sequence ID" value="XM_012912191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D975"/>
    <dbReference type="STRING" id="5866.A0A061D975"/>
    <dbReference type="GeneID" id="24564000"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206170"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="86"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="491" mass="54195" checksum="678332102A153763" modified="2014-09-03" version="1">MLNAQIQLYTVQALHRANGKLATFGTAAIRNYAHGRLGCRRIDEVHPVIGGGVGSVLRNAAAIGSLQRLEVCSARRQWRAYNEGRVYLDYQATTPVDPRVLDRMLPYLSHSFGNPHSRTHSFGWDAEHAVEEARSEVAALLNCDPRSIIFTSGATESNNLAIKGVTEYYSNLEHPDPSKIKDHIITSQIDHKCVLQTCRHLENRGYKVTYLKPDTKGVVSATDVAAAITPKTFLCSIIHLNNEIGTLQNLEGIGQTCRERGVIFHTDAAQSFGKVPLDLSKLPVDLMSISGHKIYGPKGVGALYVGRRPRIRLRPIIDGGGQERGLRSGTLPTPLVVGLGAAASVARQEMQRDLSNARRLWQKLVDGMRDIGHVHINGPVKDGERYWGNLNVSFEFIEGESLLMSLQNIALSSGSACTSTSLEPSYVLRSIGVGEEVAHTSIRFGIGRFTTEREIDQLLAELRSAVERLRSCSPLYEMFLEKESTENMIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D997</accession>
    <name>A0A061D997_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-type ATPase, D subunit family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0310210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769304.1">
        <property type="nucleotide sequence ID" value="XM_012913850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D997"/>
    <dbReference type="STRING" id="5866.A0A061D997"/>
    <dbReference type="GeneID" id="24565659"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310210"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="255" mass="28734" checksum="C001D49BF8A0737B" modified="2014-09-03" version="1">MPNTRCYLETQNEHRFETLQILKQKRTNAFLGYSLLKRKSDALTSKFRKLLKETIEGKEKVIEGFNEASYALANAVWSAGDFKSLVVESVGRSAVTLRVRTENVAGVILPNFELRVDPTVDVIANIGLTSGGNVIHSAKTAYLEFLETLTALASLQVSFMMLQQEIKMTNRRVNALDNLVIPTIDNHVEYIKRELDELEREEFYRLKMVRNMNQDDDVPMKPASSGSHDGGFDNNSRSSDPPSVIFDTVDDDIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K3</accession>
    <name>A0A061D9K3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0312540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769537.1">
        <property type="nucleotide sequence ID" value="XM_012914083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9K3"/>
    <dbReference type="STRING" id="5866.A0A061D9K3"/>
    <dbReference type="GeneID" id="24565892"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312540"/>
    <dbReference type="OMA" id="HTIESCM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="124"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="409" mass="46155" checksum="60B569FF3E4103B7" modified="2014-09-03" version="1">MKMKIALSQATTLGIDFVKCIETLQTSPYCKRNSNAELTLAILEDMRKKQNVIDAVSYKLAICTCAKCGYTDDALQLYDEMIRNKHAADHGVMRAIMAQLAKEGRGMECSRMFQDMKKLDAVTKGDETFVQPADYLKVIEACSKAQLYGEAFEAYKEMKQLKSYSPTPAVVNEMLSLCYMTGNWREAMELYAGLVKENKTPTLHQFKLLLSTLLMSRKFTEMESVYSQMQQEPIQMDAMSYQLLLDAYAKTGQFKKALKIIEDMERQRRLQGQYEPFISAVEACRQSGEWKLALQLLRKAHEHNTHKSIDMYNAVLAVFSVAEEWDSIISLHREIDNACKESTGTANSVAMNGDTVAYAAMAYFYTGDRTQANTLLQLPVTDTPLLVKIRSSIQAELLSEAPGRGEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9P7</accession>
    <name>A0A061D9P7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767830.1">
        <property type="nucleotide sequence ID" value="XM_012912376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9P7"/>
    <dbReference type="GeneID" id="24564185"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207980"/>
    <dbReference type="OMA" id="YFVELYY"/>
    <dbReference type="OrthoDB" id="361106at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="831" mass="93909" checksum="EB9849D32B35283F" modified="2014-09-03" version="1">MANPALALALVGRVGLANINDPVVLDSIKAELAVIEGQLQDAGEVGAAANNEHVPNVDLHVKGDVGAPVASAARESARKIHITVPEVELLMHLMQEQSDGDKTATITSSRQSKGIQLIMIARNLLQQARDQTAWCSLLSDNEESEQTNVKWEGMPRLIALLVLTVALESSAGGKTYVAVSTLSNHIQQAFRYSFQSPESDLCLIDHPEWAINYIRDVVKRYCAIFKLIKQEIHSNTDELFEALLPEAATLAHMEQRPDLREQFRKLCTEFSQHNFVQKWAKALAKEARWFTFTRLPLLVYEYRIALSDTLLTMQQVTIITRTADPKTRLNVSQALFNDDARANIIYSLLRAMTDLATTLRDLDNTAPYEVFADFDKNTTVPCLALKCDANQHEAQLELNYEHDRAYGALDALISLEKTAAINVVKKLLEGENILEAVKCNAVTQNNWYLQDGGFLTQPVKTFIALLKIFDERCKCLETAKSRGEFTTKVIAPIINSYVEYIKGKWNAEDDVFRSCSLTAFLIDATALLYEFLLRYPYSQYMPQVVTTVERVTTKMIAIIGDYVNDIIEEPFSRVHDKRLDIMYYLRDKMTQLAVHCSLKSYKQMLRHVVDNVERRLMAVLLPQRASQIILNTPAHVEMAARNWWVNANAHVNICRSEIVYNELKNLTDAEYCPEDMQTIEDVKAILATNVNELVDAVESIKGDAAFHPVLKDVNTKIYLQRRGVRSTEAGTRYLHTAETRIIESCGNEAESTKTLLDDILSLEESDDRESPRLSQPDKAPLNQNESGEQEVAEKVKKRFKVQKLDVKQVYTLSLHVLSAQIEQQQFIELVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q0</accession>
    <name>A0A061D9Q0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768888.1">
        <property type="nucleotide sequence ID" value="XM_012913434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q0"/>
    <dbReference type="GeneID" id="24565243"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306060"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="97" mass="11072" checksum="0836E5B4D84DE1D0" modified="2014-09-03" version="1">MHGYFFTLEWRGDESLWRGGPPVHITIATARVQSVLLSDGIARLLRMLFYQQTPDVAINAKLAIKECLWSVNRHSNQFNTLVTLPAENHIQPEQCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X0</accession>
    <name>A0A061D9X0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0306710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768953.1">
        <property type="nucleotide sequence ID" value="XM_012913499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X0"/>
    <dbReference type="STRING" id="5866.A0A061D9X0"/>
    <dbReference type="GeneID" id="24565308"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306710"/>
    <dbReference type="OMA" id="MCIQNNI"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681:SF26">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="162"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="945" mass="106946" checksum="6DCA56BF31D5376F" modified="2014-09-03" version="1">MENRESYEDLQAKIADYREKIQLVQEALEQDPDNDELKALQADLLEVIQLTEDLIQYKRQNEATAISTAAAAEAPEPEEATSATGGNAQFLGMSAAATTRGSCNAGRICVVLYNGKQKFGQIIQLLGDSPSDQVVIQLVGSGEQCALAAKDLKLVDAPAPDLCKPGTLVQVLYSEDGRWYDAVINRETETGYVITYKDYNISEEVARDWVRLKIRQDAKSKEVKEIVTPAGYRIPENLIIKQNDNEKEKMRKKKLVQTLKKQQKAERIESEANQRANSWRKFQEKAGSKNKSGYMTGKREGSIFSSTDQDTSLSAPNILYNSFVPRKKFDFNERQYIYRNTLKHMAESGTQSAAFNGVKGACHISDGFLFFETESGKFKWSFSTWIRSEKSKKAAKVRLTFTEGPLKLTPDDAHAEALEKAVIVVDFGDDRDVLERFCSQVSQESAPVKVPKVVPEVPEAPRKAPQEVVATAAPVLPKEDHKSIIHRNKQRLLQAGGDVAQLYQQLVEAEEGSAEGVVSPDDFWSHHSVDLIASLEQPEAPSHLDGFIAIPPSSEFVNGHRLYRYNPELGRALLAEDETIRTLHQKFVHERQYPAESFWKRILQSRHFYHIIGEKIPENQVLYDDIKGVPIKSFEQPQPAVGSVLQQVDPLSDVIRVDDLTKRKPSASSVAKRFGDQVAVDSKPSIVDRFNAHAAKIIDGCSRPSILMDCKVDPKTLEERAETERKRKIADVYFHDLSTQYDQSTDDMCIIQGLNMPGYASSRSNSFDEQRGDHREPVKKIAFKMRTNADMAREISQSVEEMRRFDIIKYIRRPMNDDTASRRMFILNTKLCQSEKITQTVPLEYDDTTVNRMRQYQMSIMEILQLYYKTLLPEEQKRLKLLIAIRQLKGKLEGQQEFGISAYAAKPLQTGLMNQITAVEVYDTKLKAFVADLRNQAQQRIVKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Y5</accession>
    <name>A0A061D9Y5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0312160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769499.1">
        <property type="nucleotide sequence ID" value="XM_012914045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Y5"/>
    <dbReference type="GeneID" id="24565854"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312160"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595943" evidence="3">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="236" mass="25828" checksum="087237D66444433F" modified="2014-09-03" version="1">MWLAILGTTGTWLMLKLVGAQLPWLRLRGLGAAVVPVVVEGTGSGSGSVAVGEWEGKGKMSYYWPGKPCTQCHNNCKRSVVCNCCRWCCEECKAGRCNDCWYDFNFKRKYSSHCHPDGCGKKKKDCTNPKCDCTCCKEKRSREPAASESLSSPDALSQTASEPHLSDIRTEESSSGDSNAEGSTPSPPPYSAIAAVIVSIIVAIILLDLCIFRFPVGRNIRDFLVRKIPVCIAFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA20</accession>
    <name>A0A061DA20_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769752.1">
        <property type="nucleotide sequence ID" value="XM_012914298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA20"/>
    <dbReference type="STRING" id="5866.A0A061DA20"/>
    <dbReference type="GeneID" id="24566107"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400580"/>
    <dbReference type="OMA" id="MSPGWEH"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="486" mass="53441" checksum="7F338A88EA86E44A" modified="2014-09-03" version="1">MNTAKTLRTSNFKERKKRNHDGSATSAVAGILLGGLRKHKIGLGDDSSGALCDPLLKNGNKRVVIKAGSIKNDWLGLWKAPLRNPFNMYGTVPSQIMLRDKRKTFSFPPLTDGSGESTDAVDIRECIDSIKISSVAGEDAVAGVCKDVADRLPVTGSLDVNRISTILSEPKSSRSSVTASTARSTIDSFRYSDSFDDLVPEGSAGPSSSSHLEVLLNNLYITTGNGFLSGSLPENPWKNKNQVDADFIAVSLARRRHSNPALLLFHDLEAIVSAPSRFCRCGFPHLPHHSVACSLCTGATSDRFGSVSANSISHGTTSPRLSSPALRNNQSHDARASNHKIPSEEEMLLWSASTDSARATIRRAGVIQRPVKFDVNDDFMVTDADDYAALQTRFGRIIYSPKFKDQHYMYRFVVLTKEAQEAVEALSRTLPNNGKLPCSYIPSMGGKRFLTEFEIVRQLGIQMSPGWEHFMYFKNTQKELVLRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA61</accession>
    <name>A0A061DA61_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0307410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAP2/GCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769023.1">
        <property type="nucleotide sequence ID" value="XM_012913569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA61"/>
    <dbReference type="GeneID" id="24565378"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307410"/>
    <dbReference type="OMA" id="EVYEIRP"/>
    <dbReference type="OrthoDB" id="365272at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040326">
        <property type="entry name" value="HAP2/GCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018928">
        <property type="entry name" value="HAP2/GCS1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764:SF0">
        <property type="entry name" value="GENERATIVE CELL SPECIFIC-1_HAP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764">
        <property type="entry name" value="PROTEIN HAPLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10699">
        <property type="entry name" value="HAP2-GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600734" evidence="13">
        <location>
            <begin position="35"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="684"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Generative cell specific-1/HAP2" evidence="14">
        <location>
            <begin position="83"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR96837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="759" mass="84333" checksum="45AAA4C3C5E2E7EB" modified="2014-09-03" version="1">MTHAVLNRSYKSPLRGAACLLALLIGAAVRPASAVIISPVRQCIDKGGRSVAEGDCEWRSHTNIDVKGGEETASYVLRRKDKPNSGLYIHIQTSLTTLSYELEYIMDVPSQYREHNRSVDYSAMTGGCNNCDALELEICSKPDALPPSIQESFNNKACCVCGVNVTDYSPRADFSCTGFGAAFMHGKCVSMSCLEVVGPWYSIFKPAYPPTIHRRVFVDVYAFDGDAGVVPDVAKNGYYTSDDADETRYLKEAVYKDKHLKATLSAEKQAVKNEELDVTLTIITQQWLDGNAPQKMDKFVAVPSWPETDKTVQGSSRKYNCDQEGRDPHECEHDDVRCRMEKCALNVRTIESDAIDTTGTQCDKIGVSMGTWGNEGRLCNTAPNSCIQNQLGWYLSERKERALLPKLYGVQPMLARREVRKSKQAAAMEEPEDLAEESRSPTAKSAWRGPATYGAEDEGEEDEDEDEDQEPDEWHDDTYVHAVAYSIAKADTSRIEINTFDATVTQIIAEAVGFIVSATMDGPCKVASHEACTMKIVTKNAGKIRAKFSHRIQCYEAEKPHTSPAASSEEQSVQVEPNSTTSSVVPIKILSGEGSDKLECEVQLYSSTVSLLETFVVKASLATPTITVGPDVRSFDKFTDTSKEDHALKIGAMLSDNMCTCNAGEVGCFFRNFGKCMRHAFNKYYTWFVLGITGLSFLALLPVFIPLARVVFGKISEGRARARIRREAAQEIERIRREFHHDEERYGRPEFRSRHSDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAQ0</accession>
    <name>A0A061DAQ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal recognition particle SRP19 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0402490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769947.1">
        <property type="nucleotide sequence ID" value="XM_012914493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAQ0"/>
    <dbReference type="STRING" id="5866.A0A061DAQ0"/>
    <dbReference type="GeneID" id="24566302"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402490"/>
    <dbReference type="OMA" id="ERTKCYP"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="14387" checksum="4BC45F86DC5698B8" modified="2014-09-03" version="1">MAAPPSSDSASTWSVIYPTYFDKKATISGGRRVSLPLAVENPRVEDIRAVCEKLKVPYVLEANKAYPRDFMNPGRIRVYFLHPNAESKALTKCAFIYEIAPLIAQLKLRQQAEATAASASSSKAGKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAS4</accession>
    <name>A0A061DAS4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0211630</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 12"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768205.1">
        <property type="nucleotide sequence ID" value="XM_012912751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAS4"/>
    <dbReference type="STRING" id="5866.A0A061DAS4"/>
    <dbReference type="GeneID" id="24564560"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211630"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="179"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="509"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR96019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="548" mass="62533" checksum="80C0E16B07AA82D5" modified="2014-09-03" version="1">MSSSTEVDAKQYHKARVATVQEWRSQNVAYPHKFQTNMNVAQFIDKYEHLVPGQYMEREEVRIAGRISRIASSSSKLRFYDMRSNGLRLQVFVNYEYHNSKSGDFNEIYNSIKRGDVVGIVGFPGRSKRGELSVFPRETMLLTPCLHMLPDKSGLKDPDTRYRQRYLDFIMNEDSMNVMHIRSRIVAFTRKFFSSRDFMEVETPTLNVQCGGASARPFISHHNELDIDLFLRVAPELPLKMIVVGGFEKVFEIGKCFRNEGIDMTHNPEFTSCEFYWAYADYNDLIELTEDYLSSLVLEIHGGYTFPYHPEGPEGPEIILDFKPPFERISLIDTLEREIGTTFTPPYNSEENCAKYREAIKNAGLEMPKPATPAKLLDKLVGHYIEDRIGNRPAFVMDHPQCMCPLSKWHRSRPDLCERFEVFICGRELINAYTELNDPFKQRECLQEQRKAREMGDDEAQDVDEGFCVALEYGLPPTAGWGAGIDRLTMFLSDRNNIKDVLFFPTMKPLPATNPTPNAPAEGKAADDAADAPAPSAGPTEGDKRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAW3</accession>
    <name>A0A061DAW3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WD 40 repeat domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0212060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768250.1">
        <property type="nucleotide sequence ID" value="XM_012912796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAW3"/>
    <dbReference type="STRING" id="5866.A0A061DAW3"/>
    <dbReference type="GeneID" id="24564605"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212060"/>
    <dbReference type="OMA" id="KQNICKF"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="251"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="562" mass="60975" checksum="1869E24B2389906F" modified="2014-09-03" version="1">MGTVKLLSYPVYSMATDGRYLVTSGGGGGKEYGIKDCVEFHKVTCAGRRTDMSLAASSNDKLGILDTVQHIPMHDLWMGACGQSTVFFTTCQTRGVRIYGRVIVARSKDEPQQTAARFCAGVDMFVTGNSDGTVRIWGLTDSFLEKVAEMEDDPDSNKHPPLGYTDDLVLTYDVTPGDAEYGMSPMNSDSPESRPSAMPDDSTSGFALSTPGELTGLNESNPSTGIVGDSAVDHDLVCSSLESAAPMEGAASASADISRSDTSSGDVSSITGESSIVLDSNSVGGENEENNPSEADERRPTEESGIADGRPLLSEGGSAGRPSTSSEGTPSRTDQTDFYTDSDTPHRHCDSPHPSNVALKLVEYKCHDNEITDCDIAHDGKMALSISREQMVFYQLSPPKFLCKRRSSMRFKFGRFVNSNCRDGHYQMLTVEWEPRKPTDCVVSMWRYNAESGNLMLVKSASVGRAACSCMSLGVDDRHFALGFGTGAVGVYTTRSLQCVMLEQRHQLPVTDVVFLEDKLASSGADFYVIIKSFKRWPLAVVLMALVPILAYIVHILRQRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB09</accession>
    <name>A0A061DB09_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770037.1">
        <property type="nucleotide sequence ID" value="XM_012914583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB09"/>
    <dbReference type="GeneID" id="24566392"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403390"/>
    <dbReference type="OMA" id="ERNGHHL"/>
    <dbReference type="OrthoDB" id="359783at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="24536" checksum="9F5EC85C30F8F52F" modified="2014-09-03" version="1">METSKKNHSQAQGSRDAGQKNEASPAAPSTSTSNSGSKRSGSGSHNQKNEAVEPLRGPDAFKYIGGTACTLYTRPHVHAVQVQIDLTTGERIKGELFYADVQRTPTIIIKGNQERNGHHLYIVHAQSIARLEALGPLNSSIDDIPRITPEQLAEARATLARFDEEVNPKKGHNEGHSKGNYNKKWHSRSSGQNSSQGGNANNNSQGQGNQGKAAYTASANAEAGRKSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB58</accession>
    <name>A0A061DB58_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768335.1">
        <property type="nucleotide sequence ID" value="XM_012912881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB58"/>
    <dbReference type="GeneID" id="24564690"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300540"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="81" mass="9049" checksum="48E8552098F95AE2" modified="2014-09-03" version="1">MCLDVACCESYGIFAIPVGDQHGARQEIRGATREPGELRGRRVHRSGARGIKVRERKAGKNKPKERGTCMKERGVSREARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBD0</accession>
    <name>A0A061DBD0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0202070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767236.1">
        <property type="nucleotide sequence ID" value="XM_012911782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563591"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202070"/>
    <dbReference type="OMA" id="DMAVMHH"/>
    <dbReference type="OrthoDB" id="365961at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="3">
        <location>
            <begin position="2504"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1471"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="588"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="692"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="862"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1685"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1770"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1358"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2553" mass="282242" checksum="6BFBF29483F16CA6" modified="2014-09-03" version="1">MAMSLLDAPSPASDPIGVDVTPPCLAGYRVYKDHRSKNRFYRDFRRRKRDLTVVESRFGDVLRKDGKRQSKSPQRLLDAFFNQLGCIRPQLVEYLRRNPGLLVERLQRYFGVSVHLTAPDNDVVASSAFPDPRSAEAAAAAPDTAAGEAPCEGASVPCPESDIGKELLTSVLETLSQKYEIISSLESQVYELSRENTELSLKLSDAYSELLQLELDRSGSEQRYLDALTSLTESVYISATQCSNLQNLVIKRGKQLTAQAHSLFLAENALAQQCLLNNVPCPVLSKACSRFAYDASSLENSGSTAPNIARFTLNDADCATSAYDSDLQGSLYDEGPTSAGVPSGEKGLLSATSFYESGGDSARSRQDQQPSNEGELIIAEFDGNKAVSVCHFPDAPSALPVQTASPESGAATNDAPVVEGDLVRESHVEKLLLDVSTNPPREGVEQASSQVLPPVLGSPALDSVAATAVMPSEPANATLPSPAAAPVSGYSGDHVRDDAKVRELIAEISVIQKKSQSYVRHIRALKRENERLRSRARLPEDLRAEVSTGSAGPFDYRMSGDVASIGSAFYAAAGAGPSRVSPEEDTKVKELKAEISILQKQIQRSQEASEDRQRLQDQLAAEERRNRELYSELSVARRKLVTYHNELEQLLRSYGGGAQAAADANQSSTVVSQDYDRSSKLGATVSELKTVLMTLNGRVQSYESDNDALRSELDHLRSKLSAVHDELGHLRSQNQALFADTREAGCLAFDRLLHCLTDALGGMTRTSLEELEAAPSEQGTTTLSQLGTDDLTAERITVLEFENKLFSDKLSSLLDIVHQSSLERFQMHTTIARLNSDLHSSHQQLLKFSNQSSVLLDTSNELAALRARCATYDDQVNRLKQMNTDLSDLNNRLGDDLRNLEEKSACASNEVSALREEVRQLQSLLVGDTQAAHDAIRDRVSIIRLEGRCKFLDESVSNGRVELESLRGKNSDLVKSVMELRYALEQERASNAEYLKQVNAMSEAEGRLRNQLDRQETQIEGLRASVASLTESLQQNAADMRAASERLLEKERSESALSSTIDSLGASLNSLLSSVRDAKPIPLAPADLGPIDLSSIPNFNLTVYYGVLDTIQKSAMDSHDVTDIGATAKVVSLARDKVCNILKCNYLLGALASGLCRQLQEFSASLVAAARSQDCSVTPLVKCLGESVNLELLRADFANRMSRAHAHTKELKAIIRHLYKNNPADVINRLKDHYEDALGKCQVKIEQLSSVIKSKEEDQLKLKQENSKLMSDCSTAAHALNEFDKRLELQAQERSSLCAFALSLLPPAAQTDCEQDDLRGILAALRNVISKLASYRDKYKKLLDNPPEPKVVTVTVPAPAPAPQPEPKAAPAPGAAEPAEQRAAKAPGHTSDDGRGAGNYIPSSVGHGHGHGHGPGHPNPLRDHAVRRAAPSDVPLRLERALKDVDANVRYYVKNIKSTLRDYVRNLAATQADASETDYESPRTRSVGRSDVTVGNIGDFSDTESESSELLFSDKPAAEDIIRSHARQFESICDLLDHARDVQSQVMERPPRVVYVDTPKPAPVRPALASTSDMAVMHHFHHLCAALKEYVAGRPIALSVDDVFYQLELVMLDQGDRGRRRAKWDHCVGNMVSVVIDVLRSISLDRKESVDGLRRRCSVASAALEEAQALCRLREEELHRRTTELSEACSRLESLERHCRKVEVELETLSAEVPRVNERDVRALESSLANREEDVRRLSKEVSKLHSVVFDLEEVNELLSQQLSRAKTDSERLGATVDKQQREISSLNSELALLERRTGRGARYAVWQPAFNVNMFLVRTNFAPYACRVAARRRFLSSGCPSGAAEAGHSDSCELGELRSACTSAPAAGAALSLDDLRQVTSRFRRLHRKGVVDAELCEKYSALLMSYADNAAGAAALSLDECFELFVSQCETNSSRQISLLASRLLDVIKANDAGSSLPVALKALVRLQRAKISYPELLDYVSGHVSALSPPQLADFAWACYSGGLRSKHHLDVAYGECLRRLSEFDLAELLRVLRSFSYFSYEYRAVFEQSQPALRGELGKLSQEDLLMLLNVCKTLHREGDFVELRDGILGHLMDDLGQYPTRFLLQCLAHLTRGRRTQVGGRFVSHVLRNEAECAREYARMTVPALVSVMQCLELWRTRMSHLTVILRLLGERVRELAFSRNLGLWAEVYNVVYSTGWFSPEFMRAGVEHIIAEPQILHRVSCHQVVRVLQTFYKLRYYHRGSYERMLGVFLEDFDGVSGRLNVVCEALLAAADANIEMPQLYERCLAHLSSALSELSLTDCEDPLSVMEQSHLWPRNVVTSAWSFCVMGYNSDPRFKVLLDLLGLPCVYEYPHQSSVVLMALEAAESTLVSGNWAGECEALLETYGDRMRDLERTDPASTLHDVDPEDSMRDHVDARMTFAQCQDAHFHKGRMRATKHISDILYHLGRRDVLVRVAPHYNSPYLIDVCLSNESKKGMVLFSGRELMRDHVEGKWSVVETGSTRLKRSILASTGWQVFEISCGEWAQLQTSVERKQFVRAALSALDIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH4</accession>
    <name>A0A061DBH4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-complex protein 1 zeta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0403810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770079.1">
        <property type="nucleotide sequence ID" value="XM_012914625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBH4"/>
    <dbReference type="STRING" id="5866.A0A061DBH4"/>
    <dbReference type="GeneID" id="24566434"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403810"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="538" mass="59245" checksum="B528432819901DF4" modified="2014-09-03" version="1">MSVNILNKQADSLQAMAALATNIHAAKSLCDIVKTNLGPKGTCKMLVNGAGNIKITKDGSVLLGEMMIQHPTAMILCRAASAMDEITGDGTTSNVMLSSNLMKNSEEHILYEGVHPKFVADGFGVAVEKALKCLEELKVSVGSREKLDWEILASVSKTCACTKLPRELALHIAHEVVEAVKLIYRPDQPVDLFMVEVLHMRHRLASETQLVRGMVLDHGSRHPDMPKRIENVFILTLNCSLEYERSEVHSGFSYSSAKQRERLVTSERKFTDDKVQKIIDLKRMVCPPGSNRSFCVLNQKGIDPPALDLLARDGIMALRRVKRRNMERLTLCCGGTACNSVEDLKIADLGFAEKVYEQMVGEEKYTFVEGVSNPRSCTLLIKGSSDYSIAQIKDAVRDCLRAVKNAIDDGYVLPGAGATELHIYNRLMRNISEVKGKARYGVQVFAESVLAIPKTLADNAGLDGREVVLELLDIDQEYGRYVGLDLDTGKFLIPAAEGIWDNYSVKKQTLTIATTVAQQTLLVDEIIKAGRSMSAKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBI0</accession>
    <name>A0A061DBI0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768445.1">
        <property type="nucleotide sequence ID" value="XM_012912991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBI0"/>
    <dbReference type="GeneID" id="24564800"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301630"/>
    <dbReference type="OMA" id="AKWSGYE"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="853" mass="97955" checksum="4711C547E404B898" modified="2014-09-03" version="1">MEDLLQVLSSLVSDRVRHFELVKIKKGSEHRKAYILVADGGLHLVTCSLGGLLKGGRFLYDCVKRVVKRNNVITLHFNNSPSLPVESLDIATPSDTHLYAKIKVAMGADHMRCHHEEAESSSDEGSNDSSDTEDRERTLLPFRGYKKVTLRGYFFFMRDSFEHTSFTSGRLTRLQDVGRGMSINVNIREPMSVHSPHLESLQTLHQYTRGFLNDLSLADVLIDGYYNKRMNLNNDLATWSCYHVLVKTDSSLLAYFIFRRLYIPPMFDICQDISMRFEVPLSSVEDKNLSVIYNEMCTTANSLTPVDEYNVWYKDLIQVRLDTLRFDHTMHAFLSRKGSIVPSYNKLIKGFILSALRLLPRDCVDIHVIQAIKEPMALTSDDPMDYIYHVKALVFGIGDVDESPERRELMNRFDMRLADYIAICIDELLMGSHLSLAIFTRYLNAMPDDAYKKKLYEVTAYLIHFRSSDFNEDYSSSLLNNIIESYRFDMSQVSWNSIIFNHYATSRMIEEGFFIYQYAADLRHQDGKYNPYLSLVSDILEQCRGDLIVERVLKKFLDIPQPIDASYLPLLKCLIGMLRRNIGNYKVVMIITAILTNFSFHSGAFKDHMIRQGVASVLIDNMLSSEEQIVISTLKLMVNITKTTEHQEAFISQGVISNFISLLEVCVNRNYRCTACIQTYYGRNMEIVSFSAAVLGQLFNYKLLRMTANQLEFITEVMIYSFHIGSCDPNHMVMIMFCLKKVPKTGPVYIKIGKHVIRSIMLNLRVYRDDDFVVNALELLMELSKRVQNCIAMRHVGLLDAIAEIPLNDTLVQIANKLKERITLKTRCLTMRLQDCRMQQVVPSGVNTFTSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBI8</accession>
    <name>A0A061DBI8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770262.1">
        <property type="nucleotide sequence ID" value="XM_012914808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBI8"/>
    <dbReference type="GeneID" id="24566617"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405610"/>
    <dbReference type="OMA" id="DLFMILN"/>
    <dbReference type="OrthoDB" id="446247at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600234" evidence="2">
        <location>
            <begin position="24"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="520" mass="58568" checksum="19AD0E8A0833057E" modified="2014-09-03" version="1">MKKAALHTPWVLAFTIALSVVDALVLELRVDDGPRKDVISPIYSMPVLATTSDHVDVPTYVFAVAEGGSIEGTVKVVSIEDSPVMVSAGNETNGGITGTLGGYWNSAVQLRQRIKSYKNNRDHYSWLQLIYNLFNWAFGGGRGKDDNNAVSSVSRDPTQTLDNVYIVIISKLKWNLYVKARSEYVMEPAKGSDQFIVSGYFVADMRIPIPAVGQSVNFTYKVKSTDTFVILLFNANESKLIMDGKITLKNPNNDHLSVEMMYYRGILAFWTILYATTGICALLYLIFWLRGTAKGLNYMLALNFVCVAIYLQLDRQLIQLIVDTGTYPNILWTMAHLVKRVHENCLLATLVLLSLGWQIIRENLTPTEFRTVIAVAVFACVNEFFEILVNGTDVARFAVGSVVFITTIIALNINQLIIRASITDESFSEQTGIAYGQLKAYNIFKASIFAGAFKPIIYSMVRTFCFRSSTEQMFIWDEHFMLFMDLMFDYALYCTYFGAFMLISQPPLFKHIFTQCSELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBN9</accession>
    <name>A0A061DBN9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SET domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0312650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769548.1">
        <property type="nucleotide sequence ID" value="XM_012914094.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBN9"/>
    <dbReference type="GeneID" id="24565903"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312650"/>
    <dbReference type="OMA" id="RTWCTHC"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10531">
        <property type="entry name" value="SET_SETD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="1283"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="1330"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="1460"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="942"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1115"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="981"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1187"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1833" mass="197879" checksum="E370183DEEF3F992" modified="2014-09-03" version="1">MVTTVGIKGKKPKDGIYALKQLVLESAPPEFLPFREDVLGYIRSVGSESEASDVWISKLAPRLLGDDEPVPDLAAVHRASAKRSGTAKGSNADLNAADGSVLASGTPDVRPALSGDAPVPEGNSWDIENALGAAIHSFMAAGAAKALGNTTSSHAPPATQGTPFGAPGVRSMQSQVLGNITENQRRASFEKLLESLNNSGDDEKDPSGPAQKAKPATGMDGGKDALPGGLGAALTHAATTRVDNAAVLASNAIKLPVPPRVNPVPAAVAVGSIAGAGLGSTAVVVDPSQLADPAAALSRSHAQPEKQALERGKERPRSVRAKSKESSQPGTPFSRKDEVIDCGSPVVGEHLAEVDTDLLGGDAAGKRGLRKLNARRIVDRKLVWPLNCWVCREPMDRMHPYVVCNSTCKRAYHASCEAIAALKLRLQIKPIDVETPALPRGRSARGAARGRGRSSVRASSRKGNVGAPDSLSPERVPGSADGNYTAGMEGSSLQEAYASAGRIGSTDSAPRLRASGSGSAASRAGSVSEHATGLSGRDASLRGIGAVDGTRNRHAANDNDKNELEVSTEWRKLVPSSTGWTRVTPNCISRECSFCINSYAGCSACFKFVAIKDLCRCAMDGCSTFYCYPACLRQVRLVVPDVQIMEIHQLVYGNVDRLLDENKRPIFICHGHTCWSCYDCDRYSYLWETLWRIEANRSETDYMNTAWQDLRKTCRGKVETAHFAKGKKLTRPLVYPDLRLYKTYMQSRRFAIHGVSGSTASKTLYPPSDDEDRATFHQVTSNVLMRCVRCERTWCTHCLHPDVRILQNSGKQMICQDCIHVEMVQALSQDRVERSSQHELIDPKVMVPSRHPLDVYNTVSSYIASQGLYQSKLAVKPHFLDPGSFYHVPDAAELAATCPRKIRSDAGKTRARGAAASKAVNADGADKVNDCKREAIDVVPRAKADGASASGGKRGAQNGPKGEKSSANATGSAPGVKGASGTKTNVDTNAATTPKNLVKTEGSSSASLGNAGATRVTSGSVDGGAVNQPAMAEKANGSELIRQGGMAAAVNTVSTGLNLSNAMGQPPVMPGGLPNPAAQVTAAMSPTNATQAGAGGAQVVVGEFGASVEIPVGSAEALDGQQLPAQGEKRRRGRPRNSTEKSPSSARQAKLPQEGGDTPVQEGEEVQRRKYVRRAKTEKGLKPAKTTKASKSGRSEMSSDDEGDARPKRATRPTAVRHPLIASSRRELRAQVRTRLNRMHSKEFNVMVREVDPLVVLRLCSEFRYMTSNLITDDSLRSISGVQASTKCSCTYGCSSTCANIARHVECNNVNCNLGDFNCGNRRFKHMGIPKLRLRMVEGKGMGAFAAEDIDEDELVCEYVGRVITQAQFQRCVSSWSFAELDNANQSHWYIMKVHKDVYIDSTNMGNVARFINHSCEPNCSSVPFYVNGTFRMGVFAQRRIAKGEEVTYNYGFSSRGVGGGFKCLCGAKNCRGIVGVQPDTTAETLQEIEIAKASGLEYDTLSQLMYDIASMHGCKSDVSSMKNSPSPIDILNGIRTTGDLYRYEKSQTRLRLKGESDLGSGLVMPISPVTLVVEDSMQLKHSQLNYAKLLVLGGRTMKEWDMANTKEFAAGIPWGIIALENNKATMTKSLESGCAFPDFYSRAKRYIQTMCMALSRQCAGNQGCENVQSLMDLTWGATEPCYVCNGYGDCKNCDHCGDVLHDDNACGDFYVNRAGMNLCNVCQNSDHRLAWLLSSDIAKESMAMRLWRLRMEMAYRQSRATFRSLVAQHKASANESAETGGSQSRVYLRPEALLCTRRELERFNKSPTAFYDMQVKYHTQCQNALSNYECFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW7</accession>
    <name>A0A061DBW7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769658.1">
        <property type="nucleotide sequence ID" value="XM_012914204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBW7"/>
    <dbReference type="GeneID" id="24566013"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313740"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7025" checksum="61C3A6AF9F5383B5" modified="2014-09-03" version="1">MVRLCNNSCSKGDCAICVGGSIAIGVVAFPALAVLVLYILGIFYNKSLGTIFAEIRDGFRGSKPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC01</accession>
    <name>A0A061DC01_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL3c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0405970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770299.1">
        <property type="nucleotide sequence ID" value="XM_012914845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC01"/>
    <dbReference type="STRING" id="5866.A0A061DC01"/>
    <dbReference type="GeneID" id="24566654"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405970"/>
    <dbReference type="OMA" id="CTICEFM"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595999" description="Large ribosomal subunit protein uL3c" evidence="8">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="323" mass="35711" checksum="07BFF9DB55716524" modified="2014-09-03" version="1">MQQHVHIVLVILAVTFLPFNAVLSAYIRREVEPCPKGFGDRCAGRGKLLVSFLASDKIPFGAENELFRRCAIKEPLPSDFALTPKDRTIIANDPCAPRPYLWNVRWPETERKIELRAIKYHVGQIWSPDGHVETVTALKVLPCTICEFMDFGYALVTYGRPAWEKRWKRRSELGKLIKNCENFSNMKPVKLQPPQDFVLGQILDISMLVGCTHVKVTGTTKGKGFAGVIKRHGFARGPMSHGSKHHRGPGSIGASTTPGCVKPGKRMAGRLGGTTCSFRKLKVLGINPETSLMYVKGLVAGSKGSYVSITSDMQPPTPENILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC03</accession>
    <name>A0A061DC03_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767471.1">
        <property type="nucleotide sequence ID" value="XM_012912017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC03"/>
    <dbReference type="GeneID" id="24563826"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204430"/>
    <dbReference type="OMA" id="YLWKRIN"/>
    <dbReference type="OrthoDB" id="365869at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600252" evidence="2">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="26018" checksum="8090138682E4DCC8" modified="2014-09-03" version="1">MKRVALMGALAALLSAHKAAALHLSKDTFTSPHDGDLQFSHMGKVYGPDANKGADNATEVSGSAPATTTPGSSGNTDDVKGGSERSMDNVPVADLKRADSGSGGTNNTSTNNTTSTNTNTNNSTQSDNNSKTDQSQSYQHQTTHGATNYRGDTSTSVTNNFFNPPMPEYASEVYPKGAKLELQYLWKRINVIDDKLDRLMPIAAGDPRLDPSKRKGLIITFDAQSDPDSPTLNLEDSYSDNDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC55</accession>
    <name>A0A061DC55_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0204980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767526.1">
        <property type="nucleotide sequence ID" value="XM_012912072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC55"/>
    <dbReference type="STRING" id="5866.A0A061DC55"/>
    <dbReference type="GeneID" id="24563881"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204980"/>
    <dbReference type="OMA" id="CTILQIH"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001922">
        <property type="entry name" value="DEAH (Asp-Glu-Ala-His) box polypeptide 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="204"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="668" mass="74662" checksum="9EB6C03BB6AF0CB8" modified="2014-09-03" version="1">MDATTELPIWFHKDEILSKLRSSQVLLLTGETGSGKSTFLPKILHENGYSDSTIVITQPRRVAAVSLARHVASLFSCDVGKLVGFAVRFLNCCGEETKIKYVTDGVLLREVLVDHLFSKYSVVVIDEAHERSIRSDVLLGVLRTCIPQRRDLKVIIMSATLRSSAFANFFTDCEIVRVAGRTFPLDIYYAPQPQEDYLEAAMLTILQINLTYKNGDVLVFLTGQDDIEALDHMLQNKVAVITQFLKSSGVQVGGNVADVMRATEVLLGDTPYELKYWKELEIVSLYAALPLQQQSKVFKPTPDGHRKVVLATNIAETSVTIPGIRFVVDSGLMKQKLFCAKNCFESLVIQKISKDSADQRAGRAGRMGPGKVFRLYTTESFTSMRVSRIPEMQCTNVSHVYLELKMIGIKNPLDFPLIDPPSKNALLAAAMELYRLDALDCKGNLTETGKKMGHIPLLPRHARLLLCSAEFSCTSEMLTIVAMLSTDLTLFSSEKHDKEAFKMRKNLANPSGDHLTLLNMYTIWNDTPNRKETCKQFGFNAAAFERASEIRSQLVEILTKRVGFINIPSCKDSSEWDNVLKCLCKGGWMNMASINSDSKSYKIEIQNKTVVIHPHSVLFSKRPLPPLVVFDECTSTRKAYIQNVSEISQDWVTQLLPRLSLTGSNTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA1</accession>
    <name>A0A061DCA1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768780.1">
        <property type="nucleotide sequence ID" value="XM_012913326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCA1"/>
    <dbReference type="GeneID" id="24565135"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304970"/>
    <dbReference type="OrthoDB" id="367212at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="140" mass="15514" checksum="A86FAC27F32FA4AB" modified="2014-09-03" version="1">MLHLVIYAVCAENVKDEFRRCSQLSPRSLGIGQHCLATCEGVCNQRVAIPGTILMRVDDVGPIRSDCGNGKQRYMCISTPATPHGYPLCTLLDPDYYKDPSAACWTECLQRKCPEGMVPKDSHRTNFGCFDSNSRVLCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCK7</accession>
    <name>A0A061DCK7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770023.1">
        <property type="nucleotide sequence ID" value="XM_012914569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCK7"/>
    <dbReference type="STRING" id="5866.A0A061DCK7"/>
    <dbReference type="GeneID" id="24566378"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403250"/>
    <dbReference type="OMA" id="TADPMAN"/>
    <dbReference type="OrthoDB" id="366394at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="880" mass="94293" checksum="8E69404E5ED2001A" modified="2014-09-03" version="1">MDGRGDPWGGNNPAFTRKVLHTKMMPKGLPYMMQMVTPQGMYPKGGNASNMMMPPGGKTAPMPPSRMPLYPESVGHMPKMLGKLGPGYMPTSMQMDPRGVMPQDRMPNLPAHMSYRGSTGNSPVGMAHQRVPPRQLQPGPGAMAHVPSPTSVGHGIMAPGMHPGMSPRGMAPNMSPSSMGQNHQAPAAMPSNVSPKNLQRYTPDPRHPHAVTMGNTGRGTASPHYASQMMGPPKMGPMAMPMGGMKVQPGPASGMGFMQVPPPGSPHMVMSNRRPNMMMAKPRMPMDMGPGSHMKSPSPVSGVNFPVVAAQPSGFPRPTSQPPKPTRTPPKRTGESRADRSIGTPQSGSSDGALALPKDVPMVDSDAAEKRASQIIEQMEKCLLELLSEQLKKAEGLYGKTFTVDESEVTSALIKGFLPILGALWREIKESHKYSLDELYLELNNPDAADKCGVVVNRELRSLEEYYRTKRDIEKVLNMYRSRTKPANKDNNNANAAEDQAATAATRAQEYAEVGYNQRHLVQKITALDYRNALAGDRCKSMMPESFRVQQIKMASSLHFDIRTPPQCISPPPEAADSNAAEIALSKCANSMDTSQFPSIALKLLDRSKHNRMDKGGDVPMLPMDMRYAKTPGMALPPEVMMQMPAVKPGFAGMPMHFPKGMNFPMMQMAGMMPMGPGVPPGMPAQFGHMGMGGVPGKQVVAPVKTPTGKQPAGVPNMQGKHGGVGPQNIPGQPGGLNAPGVPPRQGSMGIQMPPTQLGAKSFQGLHGKQNAMMMQGQPSQLGPMGFQGAPGKQVPKGMHGPPGKHGHLGKHFIPLMPGPQGKHGPLMPQMSGVKPGPPKPPIHMGMKAHSQQVGAPMPPPTMHPMMLKHPPPVFGSKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCK9</accession>
    <name>A0A061DCK9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotide kinase 3'-phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770028.1">
        <property type="nucleotide sequence ID" value="XM_012914574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCK9"/>
    <dbReference type="STRING" id="5866.A0A061DCK9"/>
    <dbReference type="GeneID" id="24566383"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403300"/>
    <dbReference type="OMA" id="TPDEYFY"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="365" mass="41311" checksum="352DBF28C44C95B5" modified="2014-09-03" version="1">MQLSKAIVICSNQSQLFEVPRVSKLIFARIQLLLNELDIPLYILLGFRRDLSRKPGPGMLTFYEQHLNEGIEVDRANSFYVGDAAGRVWTDELLDAHCERVMALLKAEDFSNRSYVRKDRYFNDEPVDANAIIAKLKPASLRNKFEADFSDCDLKYALNNNVGFYTPEEYFANHPSMPLTVDFDPKKVGTNPAPLDVTGGMVILVGPPSGGKTFLCKNKFASFTRINEDELRTRDAGVRAARECLQRGENVIIDGANAIPEKRRDYIAVSRAAGVSCTVVFLDVSVNFSLHFFRYRKVSCDVGTQFTPPQIVEPQEYAHLSQNVVRTYFKQMQPPDESEGFDRLLRITDETFPVQHTPVSQMHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN6</accession>
    <name>A0A061DCN6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767866.1">
        <property type="nucleotide sequence ID" value="XM_012912412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCN6"/>
    <dbReference type="STRING" id="5866.A0A061DCN6"/>
    <dbReference type="GeneID" id="24564221"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208340"/>
    <dbReference type="OMA" id="VFYCAWQ"/>
    <dbReference type="OrthoDB" id="364432at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="554" mass="62684" checksum="274E1B4E66727707" modified="2014-09-03" version="1">MTLLFSCAYLVFGVVLYGRSVRVCTDPGNAAFLPSVGVKNRGDHARAASPFDEAEVRKVNPPLPPPPPREPAQYVLDDALSAYRYANFAQNGPTTRHLACLPFTEVRYQDKGSLVPFRGVDEVVSCYSNKLVTLISNFREWTCAFNPSGDGLLDLSLYNPLSTGSYYAVVFYCAWQRESIALKRAIHQLAGRYTFARDPPVVHGKKPKEKLDDLLTRLDEVKQRHDELVAEARSSGLPDPPRPPLVEPERVTLTMRSHNAAELSRILEVLHDRYSYRWWMPHVGKLKYNKVFCRAYNELYNTSYRKVRSESSRLKYKLSDTGRRDVEPATSTQRSPQVDGGRNLTRVNLILVRLANSLMLSNSRRGLQRMRSAAKGHEKEMHFNEIAMRLLLNMGVLYKDMPLICLYKCTNPVDEIAPVFARKSHKALPFSDYPPFYRPDPFEIARGVLYGLPTLRKVSHLAIPSDFACLGGIRGLANLDKPPSVDEILGEVDASLHCDFQRLLQPLEKGEPADASDVDRLAPFLSTLEVLYKLNLRQYIDAQPVPVVYRFLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ4</accession>
    <name>A0A061DCQ4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">-DNA excision repair protein ERCC-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0404250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770123.1">
        <property type="nucleotide sequence ID" value="XM_012914669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCQ4"/>
    <dbReference type="STRING" id="5866.A0A061DCQ4"/>
    <dbReference type="GeneID" id="24566478"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404250"/>
    <dbReference type="OMA" id="PHCVLVH"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="7">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="208" mass="23554" checksum="3DBFEAB51ABB992F" modified="2014-09-03" version="1">MDPEAATPGEKHCIVVSPRQRGNPLIRHFVNVTCVEGDTPYDYKLTEGIQALFLSLKYHRMHRGYIGARLKQLRGHRVKNPFIVCQVDIEDPQDTIAELTVITFTLGYRLLLSWSPRESAAVLEALKIDGHKGLEFLNPRLEQPHLQIVQRIIASVKHVNNTDAITIASRCNTVKQLMHIKSDQLENIHGLGKRKVKSILAAFNDAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCX9</accession>
    <name>A0A061DCX9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770258.1">
        <property type="nucleotide sequence ID" value="XM_012914804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCX9"/>
    <dbReference type="STRING" id="5866.A0A061DCX9"/>
    <dbReference type="GeneID" id="24566613"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405570"/>
    <dbReference type="OMA" id="IFKKCPP"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="299" mass="33939" checksum="10F2425A5A175250" modified="2014-09-03" version="1">MGIADNPKYRRINDDIAAGRFYDSLQHVLSASQRAVIAKRYSEALEVLHHFAEVYIRAGEYAQSLELMKEYMKIASKSDIEFTEANIDQVKSFFCTVKDSLSCAQEPLSGPLAKDAILEKSLAIADSALELNPHPKLQLCIGQHHWDEGQLSEAQGYLIQGQDIEVLSKFLESWASIVQEHERPFVYLRCILIQLATGDDATAKCLLLMLNQDFESSDTLAYIFTELCENPDYLLYKVACKVYRPIIDADPNFPRLVHHLRERLFPGHHDPTDPFQYDPSSWDVQPSPATAMEPYSLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY6</accession>
    <name>A0A061DCY6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0209680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768001.1">
        <property type="nucleotide sequence ID" value="XM_012912547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCY6"/>
    <dbReference type="STRING" id="5866.A0A061DCY6"/>
    <dbReference type="GeneID" id="24564356"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209680"/>
    <dbReference type="OMA" id="GPNIQAC"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="9870" checksum="BD111E67AAF32550" modified="2014-09-03" version="1">MYFVVEQWKIINVKPSQLGPSYQQNIEEMLRNQVEGHCSSKYGYVVCVIRIIKNEIGRVQDGTGMIVVNVKYQAIVFKPFNDEVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCZ5</accession>
    <name>A0A061DCZ5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770283.1">
        <property type="nucleotide sequence ID" value="XM_012914829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCZ5"/>
    <dbReference type="STRING" id="5866.A0A061DCZ5"/>
    <dbReference type="GeneID" id="24566638"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405810"/>
    <dbReference type="OMA" id="NYEHITF"/>
    <dbReference type="OrthoDB" id="361350at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="581" mass="65208" checksum="EED0D2316DE4786D" modified="2014-09-03" version="1">MWRCRWLSSGTSTKILKTNAATKMHNKLDQLLRLGAQDAAVKHRNEVMDIAKTLLENPLNVNEEAEIVAKLKRFKQLGEPFWLDYMSRLENRIKSTHNIAPPNHNREASGAASVGRLDTNIRGLLKLARSLSDENVSSTAVASFFAKWIKKHIYDLVPGQLELLNGLLEYILRTGQQNQLSPADFDPLAECSWEAETHLLVDTLYLLGKLGIKNDTVLTTVGRAIHNDIAIGKLSAYHKTKLARAYALLKHSHITFYSHVAEELRVIFQGKDIGKYSMAGVTRGSDYVEGLGSAALAHPSGVICEILPRINTDSNVAGQQGTAESIAFKGLTEQLYSDGQIIYILDSMLYLNLHHLERYFVRLLSSAIKHCYTTQSLAQFDVEQLRSAITLLAQCGKTVDDTVVEFISRRFMQSYVDGHASNAQLTLFLKDLVKYTRHVTKKVNRRGRTCFKSAFHAPTWLRKPLSEMEDAPGGNAAPSMLESLCTAICQNVHSFEMVDLTSCIRSVAYLGLRNENFFKAFIPFFKDKIASVNHLGITNLTQAFIKAQIRDDHLFYLMGQQHQLSLLADDKAHKLYVKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD25</accession>
    <name>A0A061DD25_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769230.1">
        <property type="nucleotide sequence ID" value="XM_012913776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD25"/>
    <dbReference type="GeneID" id="24565585"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309470"/>
    <dbReference type="OMA" id="WAESPHE"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="97"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="234" mass="26988" checksum="83D728B0CE39DA69" modified="2014-09-03" version="1">MQSLLAFYTLATAAITPAIKWFSYLSLKPVEYNNMEAAIYSKTDRYVPNERWVIIGGRLTRAGVDLSYRVRQSVETVQKQSAELLQLLNKHYDEVDVVKVAFQWAESPHEVFLAVKFSNRWSSPGALVVSDESLEVKGNKLKYVSMGTQSDKKKKYILELELYDEVIKDETRVSPVSMGRFTITLKKARPSVWNTLTKGNEKIPNQQIWWDMKDKHQIACDTFVEEKPEEKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD27</accession>
    <name>A0A061DD27_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphorylase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769235.1">
        <property type="nucleotide sequence ID" value="XM_012913781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD27"/>
    <dbReference type="GeneID" id="24565590"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309520"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="OrthoDB" id="416752at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="262" mass="28988" checksum="CEF302276BC34D05" modified="2014-09-03" version="1">MEQNGGVILNRTSIPKDRVHRVAIICGDQKRFEMFKREVTNYREFGYYSCWKAAEFEYDGEYFLLACHGVGSQPTAVLVRELIELGVKCIIRSGTSGTFMPQKHVIGDICICYGCIRGDSTTRNDIDIAFPAAAHPDVVEALRNASEELNVPTHMGLCYTTDLFYRTGILGEDPKMPFVKCGVAIEDTDNSAMFTLCNIYGIRCGAICTIDGCPFEWVIGNYGPHTPQMAKGKEFMIKVTVRAAAEVTRQIKAEEAQVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF8</accession>
    <name>A0A061DDF8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA large subunit methyltransferase L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0312620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769545.1">
        <property type="nucleotide sequence ID" value="XM_012914091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDF8"/>
    <dbReference type="GeneID" id="24565900"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312620"/>
    <dbReference type="OMA" id="IGIERDW"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313:SF1">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="4">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="559" mass="61187" checksum="863C3DCEF3F03A86" modified="2014-09-03" version="1">MSSHWQKPYRLFARCVRGLEGALSSELESLGFPRHCLIKGRSGVTVEEGSLRRLYYLSYFSRLCNGVFVEAASFPLRDKAAFTDSCADITWPAFIRSNGSFLVESRVSEGSGFIHCGRYASQLVKDGVSHHFGRSLGMPTPSVSFSDPDVKVLLHVGGGEARVLVDAVGGATSARRYRYKPAISDIDPTVAVALLHDIGFASLHTSHSDLNEYERLCTGMSEDGIASVRGNEHQMDAASPCHPAATKLRSPECPLADGSNIASQSSDPCTGFTKLHSPSNSASDKTIAPTDGSVVDLFCGCGTVLIEAAMMAARIAPGSLWSSFAFQKFGIYDDVSFRRLQRYAAGTTLPKDSEAYQSLLGSFVGIESCWEKVEACLYSAERAGVLDLLRVTQSDYLKDGLYTSHRSRRNGERWRYLIAQLPRLKCKFNDVPDHDGGISVDSTCNRKSASGVNSLPPAADRHTKHTRPTQNRKAQRSSSAVSALDPLRYYKLVHNISKFRQRFFEDDAKCVLVAPSLLQLPDLEAAYGGPLRGGRAFVKSGVPSMAYHSHQKDDPNKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI4</accession>
    <name>A0A061DDI4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0313410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769625.1">
        <property type="nucleotide sequence ID" value="XM_012914171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI4"/>
    <dbReference type="STRING" id="5866.A0A061DDI4"/>
    <dbReference type="GeneID" id="24565980"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313410"/>
    <dbReference type="OMA" id="NKWDNAT"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF124">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="257"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="693" mass="76617" checksum="DEFC610D628E3EAC" modified="2014-09-03" version="1">MDANKAVLPSASSAAGAASAASKMPRYTYYLSNYQYLAPSVNHTFSADDDKSHSLSPKFGTDATCDDASSTFGDPQPSYVGPALLSSHTQATAHVGVVTSGRSMASESNYGMGEISPRFGRSEGTSSSSDRRIGSKVGSVDAEDELGCASVADEYSGDFSEASARMEEQRNLNTGLYMGHPLAAKMERWMAKYACGNMEEFRRRQKEHMRTLWRGTNRGESLDEFPIRCVFPWGETASEGNFDPLYIKVGDVLVRRYYVSEILGNTAFSVVLRARDDRDGGEVCLKISMPDTVNQAIDEINLLKILNTTNPKESRAIVQLKDYFYYKGCVFLILEILGPNLYESSRELYRRCKGPMCMPGERPPRMVPAEKAGWSLSTIRKVTVDILRSLKYMHSLGIINCDLKPENIVLNNGLESPIVKLIDFGSSCYIQERLNNYVQSRSYRAPEVILGLPYDTQIDLWSLGCVLCEMYMQRILFPSDNNATLMASMISLLGVPPVYLLEHKMNSTFMVLPNGNVADLGVSSDILKGQQKAMHSDYQSSLQCNISVSNSSRGSAVGAQLGSKADINMHADYDSMIDLNESNDSNGSPEYTNITPRKYSIMQEAVVSRRSGVARLHRVNKGIKLDFGHGRSKAKCVRIIEPSRCSIDEMLSTSTSPALEAFGDFIKGLLQYDPLERLTASTALSHRFITQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ3</accession>
    <name>A0A061DDJ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, NUDIX family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768481.1">
        <property type="nucleotide sequence ID" value="XM_012913027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDJ3"/>
    <dbReference type="STRING" id="5866.A0A061DDJ3"/>
    <dbReference type="GeneID" id="24564836"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301990"/>
    <dbReference type="OMA" id="WHRATST"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="219" mass="25024" checksum="A5015F2182C91117" modified="2014-09-03" version="1">MTQRYADTIDKTRLDSMPESTEVVVMVDKDDNEIGTCTRKEMRQFNKWHRATSTIILSNPDEPTIYYQVRDDQKDYCPGYYDLGFGGVVTIGESYLDCALRETRDESGIDFSENDLVEVAYIARDDEHVRCHYKVYVYSLFSSLDSKHIVKQVALYDGTPATNESEREDARCIKTALLSDVDKLMEQHNFTKACELLVGPLKRFVEEGGLAKLADSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDM9</accession>
    <name>A0A061DDM9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769740.1">
        <property type="nucleotide sequence ID" value="XM_012914286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDM9"/>
    <dbReference type="GeneID" id="24566095"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400460"/>
    <dbReference type="OMA" id="TRFVKNM"/>
    <dbReference type="OrthoDB" id="364923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="440" mass="49805" checksum="8EFF002465D8621A" modified="2014-09-03" version="1">MNNDGLEAEVAQEVPLVDLFAGESDYEDDVYRANEVTGGDIPANVSTYVQKAAKKGYLLSLDHLWHNTSDSTYEAPRERKNVLWDFLVYHNLREEREGRYMASVQQLEAEAVLAIKKAKVAILSEVSEGDHDGMFANDVAEAFDNQVTKLVHRFRLNAMDGSPLFSRMSDDAADAERKVSIYSYLTKNEEFCKLKSKLAAIRTAKKRLISCSLIRLLSSVDGLRGRVVSGIFEPNSRGFKRVTLTRFLRHLDKISNRSEFAGEYRFDLLKTYVQNREDFEAFIQHNATFAENSDDAAHFGDFVNRFTPDYKDLDVPSSAPKTGEEHRDSPANDDREEPSPYDHMMEFMNATPPDDIMMPPTEFDEPMYSDESHLPPDGPEDPPQGASDEVPQDTQSQLDAPREQDDAQLKLLEEARKRAAEILRKKRLSRVNVSSESGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDR2</accession>
    <name>A0A061DDR2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0303940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768676.1">
        <property type="nucleotide sequence ID" value="XM_012913222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDR2"/>
    <dbReference type="STRING" id="5866.A0A061DDR2"/>
    <dbReference type="GeneID" id="24565031"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303940"/>
    <dbReference type="OMA" id="QGILNQP"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="125" mass="14996" checksum="4BA6D45295C3B9C4" modified="2014-09-03" version="1">MDELIDSPTTPQDVKTSAMIAAENDDQLRFEAELEFVQCLANPHYLHYLAKAGYFEDQRFRAYIVYLQYFRRPEYVKFIKYPYCIRILELLLEDSFVRSLSNKQAIEAIEQQLSAHWICFKYDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS8</accession>
    <name>A0A061DDS8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA recognition motif containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0401510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769845.1">
        <property type="nucleotide sequence ID" value="XM_012914391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS8"/>
    <dbReference type="STRING" id="5866.A0A061DDS8"/>
    <dbReference type="GeneID" id="24566200"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401510"/>
    <dbReference type="OMA" id="PMAVNDY"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="179"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="264"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="387" mass="45856" checksum="9328B6F8707E4C77" modified="2014-09-03" version="1">MHRGYGGRDMYSRRDEYDIRGPPAPYDRERGYERYDVKRERSAPYERPRGATYRDVPEDYPRYRDEPPRYKDEPPKYKDEPPKYKDEPPRYRYDAPRYREAHPRYRDEPPRYRDEPPRYRDEPERFRDDPGRFRDEHGRYRDEPPRYRDDPRYREPLHPIRGGPIRRFDGRPYPEPQKSKVFVGNLDGRVSEEELTSAFGKFGPINRIDFRRNFAFVDYVKVKDAEAAMREMNERVLMGSKLKVVPHSERTRRIDINREPDFASQATVLNLDNSASWQDLKDFARQAGEVVYASVIIRDQKRYGLIEFANPSAMKAAVEVLNGKKIAQNDLQVVPMAVNDYLKEQMREAIAGRAAAQEQPVGGQQDEPDTKKELIYQDEQLDSVDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDT3</accession>
    <name>A0A061DDT3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769855.1">
        <property type="nucleotide sequence ID" value="XM_012914401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDT3"/>
    <dbReference type="GeneID" id="24566210"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401610"/>
    <dbReference type="OrthoDB" id="10675672at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="417" mass="46020" checksum="0CF16F7931B74CF0" modified="2014-09-03" version="1">MAVSAAENEQNYQAVSDSTDCNSHAKHDEDENYDEDGNDGMLMDISEMKATLKDMREMMESLKDMREMMASLKDNRETKEIAETIKSLLDLLQRGALHKDVVAPCVLKTPHPDGGAGTSPSGGGQQQLCSAPPQSQHASSQAQSVNIPETCVVKKSPNLTAHQQVVYNSLMYVPRNFKEAVDWLIAVRGDDAERNLATLGAAIYDLYVHMSGRSTEWSNLDKAIRFSIDFLEQEKLKKHLYVKMILAILSYRVNITPNVLTNIIVSAYDTENQRFLHKNGLTADTIAEKLCYVVDACAEFLGRIKNRSHYNSAYSPQATWDALFSAHPETGAVIFVGIAPMLVAGLLSLRSASLAGKLKSSPLIASKRMQELIQALGYVEPQLCAGMTASYVGRALGGFTYETINFIFDLAGFWTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDZ6</accession>
    <name>A0A061DDZ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prefoldin subunit 5 (C-myc binding protein), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770000.1">
        <property type="nucleotide sequence ID" value="XM_012914546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDZ6"/>
    <dbReference type="STRING" id="5866.A0A061DDZ6"/>
    <dbReference type="GeneID" id="24566355"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403020"/>
    <dbReference type="OMA" id="RNTEQGQ"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="166" mass="18175" checksum="947EC3D80C34D47C" modified="2014-09-03" version="1">MSIPMDAAAKAGADSPAAQVPNLSIQELNMVILRLEEEVNQMQTLVNVLTVAVERFQESKSCLDELSDRKHEIQVPLTSLVYVPGEIANPGKVLVAIGTGYYIEMSMDKAHEFYERKIGVVEDQLRKLHAICSSKNKQITQTYSLLDHKLNILRNAQAAAPAGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE05</accession>
    <name>A0A061DE05_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD BOX ATP-DEPENDENT RNA HELICASE, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0306440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768926.1">
        <property type="nucleotide sequence ID" value="XM_012913472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE05"/>
    <dbReference type="STRING" id="5866.A0A061DE05"/>
    <dbReference type="GeneID" id="24565281"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306440"/>
    <dbReference type="OMA" id="WGCVDIV"/>
    <dbReference type="OrthoDB" id="432247at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="531"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="682"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="771"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="771"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="826" mass="91155" checksum="8232F4A9F80348BC" modified="2014-09-03" version="1">MVRRLARSVYGRLTSTSFGSRPLLEGFRKGRPPAVRLRASGDAAGSSSAVETAVSADTCAPDSRVKLHPLLRLALLRSKGISQLNEVQESAFLSILSGKDVTVHAPVGEFRFSLSLKALLGAGKTLAYLLPVVNNIYNIHDLLEDLQLRSGSGPQRDKEDAVRLNALGYSRRVPHALLPRSMSDLRQDPSELDAAAAAALQSATTAQKLVDTLCKVDPRLLARGGSGLPVISRRLWGRRCRNSVFRALLTNPLGAVRCCMVVVPNKDLVSQVVSELAAIDPLGRLSVQTLTHVHRAPPRAPVVTDGVSQAAPGEQPFYPSPHTLHYLGGMDGKLRLSLEDERAMVQSVPTVPVSEGTMETVPVNMGRGKRSVVKVPMRTAPGNDLALSQLSPAIYSVDGLVPRSVEFLFLNDLLSSRRLGVVPACVVFDEVDALFENNASRSAMMEICSILRPRPRLYNPLVHHRRRRAQQPPPCQFVHVASTLNYGGLQTAGSMLYERFTSSRVISTCLNHHLASCEMRFVDVDAEFESKLRCLMEVIVANPLAKTLVYIDSLEGVRKVSSLLREKEWPVLSFHSRSSLPTRLALLETYRSEEVAILVCTDMFARGLDVRADHVINFSFPRDAATFVHRTKGTPTLVTNLVEPRDTNLASELRSSYESGRPVNQLLSRKRSFGNRYRRALQAKGAPDQGQASHFRSRRTSLRGSRVRRASDSDDDESPDSRRPRANLGRSTGKYKNATTTEEKSMESQQKYMASELPIDDLDGIFERSSMDTQSTADVGDTTGSQADEKTPVSAVQRQRADGVKYRRLSMKRRGMEFYDNFRAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE20</accession>
    <name>A0A061DE20_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0403770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770075.1">
        <property type="nucleotide sequence ID" value="XM_012914621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE20"/>
    <dbReference type="STRING" id="5866.A0A061DE20"/>
    <dbReference type="GeneID" id="24566430"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403770"/>
    <dbReference type="OMA" id="PKTLQCE"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="394"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="596"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="952" mass="104960" checksum="47D4DC2289992235" modified="2014-09-03" version="1">MVKAVDGDKAARKAKSASEFSTENMLRDIKKVVKAFGGGIMKSSGKSKKSKSKSMSLPVVKGKSSMASLISPNEDGDDGDEDTAADVAAEQVKPTKGKKEKPADRKKKTGDGDNAPADGSQQAEGKGAKISKDAMAASKKVASLRQSKRVSTAAVKTAPAAKTSVKSVASSKGASKSVPLDERDDDSSSSGNATLPQSDVEMTKKTSVEKTPATKLLFTNVKASDEAFKTLINSRTASCGPYLKCFMASAGKCVVLVASEEIAKAYVSYFNGYELNGEAMSVDISTRGPRGTAKKLHMPSKESFKTVTLKNIPKVFERDSVAKALESVDGVKYKSLKRDLEGNWAVGFETVPDCVKFTSLVNGCFLTFANETKTKKVKVMCGGPSFGTKASHAGRVFVQNLKFTTTAAQLEKLAHRFDKGAKVHMPKSGKKGFAFIQFSNIQVAEKAILRLNGTDFEGRKIRLALSLPTELYKDQVKTVDGKAEAESAAAQDKKKDLDEGDEVEEDEEADADDSDDEEEEEDEEDDEDESEEEDDEDEGEEDEEEEEEDDEDEEDDEGEDEEEEDEEESEDQKTSGKGKPLRSSAAKTRKNDESDRTIFVRNLSYESTEAALREYFATFGAVESCNICKDAKGVSRGTAFILFQNADDARKILAMEELALERDADFSLEGARSARNKVKHGPAAGLGFSLNGRRLILSRALSRDEASTLAKAKEQKRSTAPNSKKRNDLLMEGVILETSPEFQKLTAMEQKLQTSSFKEKLEKMKNPNMFLNPKRLCVRNLPPNADVNELRRAIVAHFRRNVDLSSICGSKKVDASRTIGKVTFLSDEKRKVKVGESTMRRRMPFAFIDFNHEELALQALRFLSCNADVFGARYRLFAEFAIEDSRALYIQKKRKEQYEEKLKERIAAQEDEEGAAEDGKKRKKRKTYSRGKLQRMKRRKLREAAAEQPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE59</accession>
    <name>A0A061DE59_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770190.1">
        <property type="nucleotide sequence ID" value="XM_012914736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE59"/>
    <dbReference type="GeneID" id="24566545"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404890"/>
    <dbReference type="OrthoDB" id="365900at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="375" mass="41901" checksum="A10872013FE590D3" modified="2014-09-03" version="1">MHDAAATSVAPGHEEIDLTTLNEPEVETERHESEPVTTDLPDQGSRHFNTHVAVLYDAFTNFKDRASRRFKERVMTFMRHENNTNTTTNASSTSRSRRDVEGGEVRRASDVTYDSLIFKITLILGFVLQFPVLWVAGSVLFMMTSNFKASTIKWGCVNIFLSVISIMYMVQQWQAHSSKLLYNPVADEAIIFESNRAQQHWYSAISEDNQLMVLKEFHALKGQRWVAQADGHSTSGFTTVELGDDKCLANPDNVKDGYGIYISNGKEVEIDGWIQFGAILSNSFTTKRSDLLVRYGVAGKYPVTFQPYDSPIFDIGLKCTNGKGKVVWIGVSASKANQKGIESNVFRLQGAHSCLLAYTTTGSRPLVHSAYIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DED3</accession>
    <name>A0A061DED3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0309830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769266.1">
        <property type="nucleotide sequence ID" value="XM_012913812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DED3"/>
    <dbReference type="STRING" id="5866.A0A061DED3"/>
    <dbReference type="GeneID" id="24565621"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309830"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="146"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="481"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="724" mass="79821" checksum="20E482638E7672F3" modified="2014-09-03" version="1">MPYNVNRLCRSLSGLSKFQRQPRTLCTPTDPAGWAASRSEIGREAWRDIAWVRHRRRISTQKATPNHVSAERRQYEGAGAAFHCGWSCLGGKQAPEHAALLSAKRAHSTGPNIERSEEIQRIKAGKVLTLRDLLWPRDQMLKKRIALSMTFLVLSKLSTIVIPLCMSAMIDAIAANPAANAGLLMNVGLGGLITTPLGIAQVYLVAYCVARISAAFFTETRNAVFSTVMERTGMLNASKMFMKIHCLDIDFLIAAKSGEISNVFTRGIKAISQVLRILVFQIVPTVLEFAMVTALLCYKLGPTIASLTVGTMIVYVLFTALVTQKRMVLRKQMVNAEQSAAGVFTDSITNAEAVRYYNAENRELQRYASQQSDYENNAVRVQQSLALLNFGQNAIFNTGLFFSMWLTLRGIAEGTANFGDLILVNTLLFQLAIPLNLIGTMYRETKTSMVDLQKFLSLMQHEPKVHDKPGAKDLVIKAGKIEFKNVCHAYENSVGALKILQDFSLTVEQGKTVAIVGNSGTGKTTIAKMLFRFYEPSAGQILIDGQDIRDVTISSLRNAIGIVPQDVVLFNETIEYNIRYGNPDASMDDVVAAAKRAGIDDTIRHLPLGYNTVVGERGMKLSGGEKQRIGIARCFLKNPSILVFDEATSSLDAMTEHKILAAFRSLSADRTTIVIAHRLSSIIEADEIAIFCNGKIVEKGETEQLMGNPNGYLQEIIRSNQIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DED6</accession>
    <name>A0A061DED6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769281.1">
        <property type="nucleotide sequence ID" value="XM_012913827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565636"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309980"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1677"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1739" mass="195346" checksum="49BE86E447F12DF1" modified="2014-09-03" version="1">MAPKNLTDCPENLREAIDWLIQVRHGNGDKNGLDELAKALKKLIEEAIEKAYTTNFDALLKLLHSAKSYTCCKEKVTEIEGFNDSKNNAPRSFEELKSKSEGIKNCYKGHLDSSQQKAYDEIQSKLEQLKSLNESLKGITVEKNCKELLTNLCDGLETFLGFSSDSKGYTGQGIVYSDLDRLCDAVMAFFHGVLSNIQGNLGQHNGQIDEAIRFITANIHGSKDSFNKAINAVVDGVRNYNREVKASNEKITLVITTLSGQMKSYSKDALNKILPGKNELGRPLVHSSEKIQEAVEAVDKIRETECKKPISEFFIDMLKADKDIKDLSPELKIQIENAKNLVKEHAAWLSSIHKHQKSDRDGVIKHVEKQLEDARDQIKERIRSDINKLLDDLIRRVQSILQLLKRIEKNVQQYVNDLDLWIMEADAIVREAESKVDRILEEVDNPAKCKEEVKAAAEYIKGHGLTLHEKFTELKDKYNNVFTIIKGKEGDGEDDTCVVKKLSDAQTKVNEPDDLETWRDDNGNWDVSNSIDPLIRKIKENFSNYLDTLNDALAAGVAEQKGITVNADSTPALDVLVDNVGEYELKNKLGNLGTLLETAKLDKDDGGLGNNIEKVLKHLYEAKKGWNARKHISDIYHTLKASMQEKITAVNRELGQLLQAAAITGAANLHSAVMEIVSSDFKTIEMLNGDIVIAAQETQSMIDNKAEEVKTNLHKLCEIVKIYAEGGEVSAKGKLLELKKKMGKTAKGTLAEGVLRKIHNDIDAILRGDLKDSIRETTEFLSHAEQEKKNTIQVLQHLVTTTIDGARDTITDDIKTRYVQLIKAQLTAFADKVSTAIAPLPNEITADADKGVKGFMRVMQDKLRDSGLNTVLDEYATLQTLSRRAKTFFTELPKTLNTRSKIMPPDYLSKLQNKLHPLFTGLTKYNRKFVAGLTALNSLLTEMNSKSYAHQNNPLLEYLKQGITDMHGELDKAYVSVYDGAEPISQWVDGKNKLTTDGKHGAKVCITILEMLFNDFNDLRIKCNQGNEYKYKTVCARNGTVENPLGAFLARCGYVVSEENKQNGELRYMNDFRGQNIHDDLLTNKHGIGDAQYKLVSDDDEKEEIKVDGEVRVKTTNLPDHGVLRKLLGYLHDYYRVCHFATSGSKKLPCNIYDMLIWLSGLPHNPVYHELTFSSFDELFDKPEEQNVDVRGTVISLAYVDNVSFAAYPETIKVSQLTSALGDVCSKSHSVLTAIVGHGHSDGVYACDYNTNEYKLQYPNSASACFDMLVDVLYRVYHQLNFLYNQCCDTTEVSGWRHCWYGNAIGGSSWKCNELQCPDQPCNPTCNQTCRQHPKCGLKSPLQSFLEDGLPGFLPHQFEKPGCKLECTVPNHRGIPCKTPMGFSDIATTASHRQSGRYLCTVLADFCGGKDSCLSKICSLLICLLNRPPQTLDEMFAFYYHLLNEWNGKSGAHEAAKKHKKYAFEDAVRKASFGFYGHLDNTTIFKSRNHKTHTNGDLFTLVCSDISEVKCGRYIKPLSHNIWTVFSQKHAARYLSWVVYLTETFYNLLNRLLNECIATCGEGNKCYVKCCAATCPVKSAYASKTPIIDLIDKHHTQDCKSITHCPSTRPTLSKYGLVFRSPYDLSGVNNVVSKRTCKDFCYALETVLNKEMHLERALAKFVFETIPEFLFRIREPFIWTVVALWSLSLLYLSYVLIGRLDTLHIKSHLRSPASYKIAAQSLLAAARVGKIAKISYLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEF1</accession>
    <name>A0A061DEF1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769356.1">
        <property type="nucleotide sequence ID" value="XM_012913902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEF1"/>
    <dbReference type="GeneID" id="24565711"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310730"/>
    <dbReference type="OrthoDB" id="365712at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="146" mass="16014" checksum="286B5717205053E3" modified="2014-09-03" version="1">MDKLIAPLVGQARAVRAGVARQALGATGGVRHVATSAGAAIADSGYVLKPVPGETGRYYLAFAKDKMEALKDLSFIDFTKQNKVQKDEFLLSVESAKTMFDFMSPATLEIIALNKKFAEQPSEDTLKQLKEQPELDDNYLMIVKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEJ8</accession>
    <name>A0A061DEJ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769591.1">
        <property type="nucleotide sequence ID" value="XM_012914137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEJ8"/>
    <dbReference type="GeneID" id="24565946"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313080"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="66" mass="7365" checksum="FF8D81C41BE43E24" modified="2014-09-03" version="1">MERLDSAWAAFARTPAPPATRLCMAGIGPPNRVYRLAEPHLRMKHDVYMDLPLIISCPSERVSDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEU4</accession>
    <name>A0A061DEU4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770071.1">
        <property type="nucleotide sequence ID" value="XM_012914617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEU4"/>
    <dbReference type="GeneID" id="24566426"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403730"/>
    <dbReference type="OrthoDB" id="361063at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="326" mass="34937" checksum="85804B4B61FBEC2D" modified="2014-09-03" version="1">MSCVHSQLLQRLNSAGVDGVAAAIRRCIFYPSILAFIFSSGLTGKEELAHISAAVLRHLPNLNASATTSVLASLSKAHYRNFQLFSAIVSHLDHLPSLGLKDARSVIRSFSRVHFTNTAVVSRCAGIVKTNIEQLRPLDACELLHALTRLRHCDQELLELLVSRSVADIPSFDDVALANFATAAAKAGVETATVAVICRELRSRAGKLGPLETVRSLLALARFGPQSDTVPTANTVLKGLNCSRLSLIQMVLALEAVSQLGCEGAERIRAALVAKRDAYPRVPHDVGFDVCAHILRQLATRIDSALALPTGERAPDSRPAGSEADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061BK77</accession>
    <name>A0A061BK77_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0005470</name>
        <name evidence="5" type="ORF">BBBOND_0308170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK055226">
        <property type="protein sequence ID" value="CDR71885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769099.1">
        <property type="nucleotide sequence ID" value="XM_012913645.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770827.1">
        <property type="nucleotide sequence ID" value="XM_012915373.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061BK77"/>
    <dbReference type="GeneID" id="24562102"/>
    <dbReference type="GeneID" id="24565454"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0005470"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0005470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1780"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="967"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="967"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR71885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1853" mass="202136" checksum="FCEECA0CEB1808F7" modified="2014-09-03" version="1">MTAHGIDLSTLKDCLQFLKWLNDSQQSSMRGKVAEELARRVSDKYNSVNTREIQNALSQFLGHVTKFHRKLCHNPAAGIYRGKNANDITEALLECIPKFLTALYYLWYDVNATFGTLGGGGWKLDYPGYEREWRMWSSSGGDLQKYFRATVSDAENYGGIIPGGFGFQEIRHNDDWYGYYQGYLMEGDIKNILDKQKNQFFRDIFATSVVSKSGLHKVNTANALALVGTFCEIVADAEKKKQVDQLKNVVKPPDKCINWGHLKDHCAQLQRQFSKIFKRQRFSHTGESPKLKDLNTRKFAQSAADWLRTNLETVRTNLSNISTSGPNIQRYRDNLGEYFTKHFFPYGFTFDNHYGISSNVAKNLPKELNGVIVEFVKRKNGLEKLREILEGENCPDQPKSSSETVSPNAKGSGTSVTTGGGGGQKGGTQGNATPGSTSSVTSKGAANKTEATTPKAAEPTAPKSEAVKPPATTTTATPPQGKKADGTPDQGTAGNGPQNTGSRNQGASNQNNGQSAAHPATSSVVKSPTSPSPGGAGASGTPGAKGDKGKQGSPDSKPTSVVQTGQNNVQKQQPLPPPQPALTPQATPPRAPAVPGPNGSPSGGGGAGPKAGDTSSSAKSQPSSVQLPGPQSSSASGNSGVKGSASVPGPTGAKGQDTQGGSNAGTQPAGASQSVTTQRSSDSSPVPPSSGGPGIGGGQVSTAVPGQQGDNGLGARGGVTDSSRPAISTSAGQLSTPGASTSGPQPSGASGSSGGQGPGGQGPASDPAQSRDQVVQTSQISNGTSSGDSGADSGGGGDRAGGGGKQKPVAAITKSIQCSANQIESVDMSGKPFCRNKPNTSYRKPLSENAVNKITNAYEKTVVENILNELNTKHPNRRILQSRIPPTPPSQPSRPAPGPYPLPPGGRDVQGRRYYEPAEGRGRHDDGSMAVNQPSEFDGQPIPDTASKELQERIKNKVEGIKFLKSLESKAQQEEVEQLRRDEKTVNAEQEKKAKAEWEKRKQQGKGVKKHDEDLDRIQKTLQRSNRANEARLRQEEEQRKFIEAAPQLDGSQATDDAYGERWPWWYPGLLYREVTGKPIDDDLPEQLQDQRERLFHEKIQDDLGRHIDERKELKTLERQEKDRIEQHNKDAEEKLRQGRIQHMQLNPPITTVLPPLPDPRELPDSLKHPDITFKVVDDTDGQSFAQKSQDAAQRIKDYYEEQKQRVEDEKKVYKEELEQKMKNATQAHVESIKRAGEIVQSEMLQKKFHGGDFDIALAPSLKVDDFEENAHEAYRIYGPSPKKTPDKIFEYNPKWNNVINYGLIVDPNPNMCNNPWNYAHDSATSSTLPPPPDSDHLPPPTNVKAMLFWLVGLNTYGLIAKMERHMENILNEINGDTFYPKYALQVNGDLSSLSASHIADTLTEACLYSAHVLNGIMRMQSGDALSDIDFKLEYDKLHYSPDPACLLCQLRDYVYACCHQLQFLKSQCSRDKLSGGWQDCGYGSDITASKSPLQAFLTDGWDSDFDTHPFDPCNLCHKSRVRMGFQANDLPKSSQQGSAISSILTPSCGGDDPLLTLCSYLNCLTRRTPRTTGELVSFFHHFGIELHDFDQSKLSKLGTSLCNPHPDCPDWDRLKNSSLHAVKGIRGTEALISKHNSNHNNEHPRTLSTLVGCSSATANCPQHCSPITYRAYALYSQSFAHTYLSWAAYLPDRLWESLDKLHYDLQKHLGSGKCSSLHSCPYAMPLLYLHGFTPPGVGSQPKLTCSDVTAKLQEIVNGGPIATLMTAMDNFLYNIREPFIFTLLTLWSTALLVLANTMLYRLDVLHIRSHLIRTKASHHIDVKALLTKGRKMLSLYKDVDYFDEDPIGQLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYX6</accession>
    <name>A0A061CYX6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765992.1">
        <property type="nucleotide sequence ID" value="XM_012910538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYX6"/>
    <dbReference type="STRING" id="5866.A0A061CYX6"/>
    <dbReference type="GeneID" id="24562347"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101350"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="367" mass="39092" checksum="8FC59669BBFCB846" modified="2014-09-03" version="1">MADSTGEDKPTHLATTVSFGKGEEGNEGIYGTCKGSTEIEHKDTNVGNMGSQVAGAGGTLALKEAVRRRILASKAAVRGGPFSSQSAVISDLLASKAAVISELLASKAAVISELLASQEAVISDLFASKAAVRGGPFSSRYACMMNIMASKDACMSNIMASIDACMSNIMASKDACMRDIMASKDACMSNIMASKDACMRDMLASKDACMRDLLSSKDACVRDMLASKDAYEGRPFSSRAAVTGDILESKEAVKSDIHASKGAVIRDIFASEEAGRGGGKDDSEAGYKGVRCKALRKIRKLIKKRYRFRSEYDRNSSSTSESRERDKNDNAREDVEHRSNDTFSAGSEDGTEDLPPEDHNSESEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D098</accession>
    <name>A0A061D098_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766279.1">
        <property type="nucleotide sequence ID" value="XM_012910825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D098"/>
    <dbReference type="GeneID" id="24562634"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="94" mass="10508" checksum="5C4FF24F4DFC65C1" modified="2014-09-03" version="1">MAAAHQTRIGTDLRDTRGTDGFWQRFTVKMLASLSSAAGLLFALFLVEKQVVLLLETTRTYALNLSHLYVQLLTPVKGVYKHTGIRCVRAGFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0B4</accession>
    <name>A0A061D0B4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766299.1">
        <property type="nucleotide sequence ID" value="XM_012910845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0B4"/>
    <dbReference type="GeneID" id="24562654"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104220"/>
    <dbReference type="OrthoDB" id="366173at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="135" mass="14869" checksum="5535FFBA5E0DF397" modified="2014-09-03" version="1">MELSDYDGRLEHDTFYKLRPLLSCTAICAILAAALHGVSANRVNCSVDLVCGLTLLCADILLLATGLAYEKLVWSPEWSKNTGIAAYVVDIIYTAAVFISLNFVWEKPSKSDDLDDQESALYSEQDDVWAPFSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0F2</accession>
    <name>A0A061D0F2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DSHCT (NUC185) domain containing DEAD/DEAH box helicase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0104620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766339.1">
        <property type="nucleotide sequence ID" value="XM_012910885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0F2"/>
    <dbReference type="STRING" id="5866.A0A061D0F2"/>
    <dbReference type="GeneID" id="24562694"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104620"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="92"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="310"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="986" mass="112308" checksum="5F94F5DA286ED378" modified="2014-09-03" version="1">MDDALSMFDAFAAATTNKVSDYENEGFAKAPKFVDAAQHRLAAQVVLEKLPGGKNCTHHRLKPANYEIPDQPTGEPARTYPFTLDEFQKKSIDCLERGESVLVCAHTSAGKTAVAEYAIAMGLRDKRRIIYTSPIKALSNQKYRNLCDEFVDVGLMTGDVTLNPDASVMVMTTEILRSMLYRGSEIVQEMKWVIFDEVHYMRDAERGVVWEETIILIPQKVHLVFLSATIPNSIEFAEWICRIKNMPCNVISTDYRPTPLQHYIYAPQSNGVYLVVDDSGRFRQDAFLKAVSTLDSVEEGRRKRGRNTKDIESVVAMCHEKKFTPVIVFAFSKAECEANATAIRTLDMTDEAEKNLITEIYQNAMATLADDDRTLPQAVFMLPLLRKGVGIHHGGLLPIIKEIIEILFQEGLIKVLFSTETFSMGVNMPARCVVFTSLNKWDGQTNRLITSGEYIQMAGRAGRRGLDEHGLVIIMMEKGIKPEEAKSIFMGKANRLDSSFHLGYNMLLNLIRIENTTPEFLIERSFLQFQRDTNARSYQRELLAVRKEMEEKKALLRHEDLLELTNVHALRKEIADKKDAVGRLVSKDLRMLNFLNFGRLVKLENEGHVWEWGIVFATPKVKVNRSTYEKQKFYIVDCLVLCDRASVSGNKREAPLPTSDVADGLFVVVPFSIDCVKEISQIRMQVQQDFRVNSELSQMHMRAKYTQLLEYLKTLPSVPMLDPVEHIKIDTPEMKGLLSQITDLEKRLSGCKVLASGDYETKYNLFMDYVKSQTKEREVLRQIEMSNQIVMKEDLRHMKAVLKELNYVDENGVVTIKGNVACEINATDELVVAEMFLRNFFENMEPEYICASLSCLVVDEKKEDKLPSDLKLVEAFKKIQEIAREIATVMAAKHLDVNVEDFVKKFKPAMMTVVLRWAKGHSFTEVMAESNLFEGSVIRCVRRLEELLRQLACTSRNIGNLQMEQTFVTCIKKLKKGIIFTSSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0S8</accession>
    <name>A0A061D0S8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0107150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766592.1">
        <property type="nucleotide sequence ID" value="XM_012911138.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D0S8"/>
    <dbReference type="GeneID" id="24562947"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107150"/>
    <dbReference type="OMA" id="CMGVSAN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="408"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1641"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1646"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1689"/>
            <end position="1718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2044" mass="227135" checksum="9A37A257621DDAEC" modified="2014-09-03" version="1">MLRYDTTVSTEVTGLSFELLSADTIRQLSVSEINNAVRHGTECAESSCIHDSSLGPSDICHICSTCNEMSACDGHMGHINFPIPMYHPLLLPRLSKLLKAMCLYCRRLKMTQHRVVKFIKMFDLMQAGLISDMLLFDDLCPDSSKSKVDLTRMKRSGNTADNQLAESADGNTASEGAAGETNLKQKYIRGIMNKLRAHKRCESLIRDTSAPDVDAKRKATEVSQEDADEAVDISEFGSSLDHKAPSKKAKSIVALPNTGNGGKSRHFDVTIWNDLRNRFVAEAGSVVQCPHCERRDMFYIRPSTDMSCIDVSWPQDIEGPPIMDHLTSYNFDFENDASDAATASQDSVTAGRQGVDLPVMNRLSATGRSVRQLQLQAFHIVPYMRELFKQNHVVLGHVFPQSRKLGWRMFMMFCMGVSANRFRPVLVTADRQLALHARSQALLDILVAKQVLCLLLKIENDANLTRFMTDADFVVGLLGNLDSRQLQSFREFVADCGSDFNSAVLGSIHALQRKVSAYADSSKVSNTMNAKVAQRPGIKQSLEHKEGAVRQNMLGKRVNYAARTVIAPDCFLDSNQMGIPLLFATELTIPENVTSYNVHLLRRLLVNGPKVYPGANFYRDEHGKLYNLGALSFNERKAKAKLLLTDNSDGRLPRVVYRHVLDGDVVLMNRQPTLHKPGIMAHFVKVLTNEKIFRLNYVNCNTYNADFDGDEMNLHLPQDPLAQSEAQLIANADCQFTVPKDGQPIRGLIQDHCLGGAYLTCRDTFLTRDQYFNLVYVAVQAFFKWHRTIYIKPEEGRKHARDGLKIDVHLHQVTRRLKVLSDPYARRCANSNAEIHIEEPAIMFPQRLWTGKQVITSLLKTLVDGIARGLHRTDLNFLQKYRGINLVSKSKTPGDAWGGVFDGNREESTIIIRQSELLQGVLDKSQFGATPYGLTHLVYELLGPRASGCLLNAFSYLFTSFLQMYGATCSPMDFILTRDAENHRSRILRRIKHCGIHLQELFISAISNKTGNGEDSKTKSESKDDSSVSEALSIFKQMTAELQEFPLLQSKLQSMPHESPDDISAVLMTVMDYLTNQKIKAEHQHKLAGILSNTIEALCSLQDLRGFILGKLPGIAEGKGKPVPPNDDKVIKHFPSWHKPYDGDSGISRASDDRQYRLADFNETCSSMYRLINEQFKGNEHDFYRMFDRFFQGNITGASNEASSVVDRTLLKFPRNGFAGMVSTGAKGSKVNFSMICSLLAQQTLEGRRVPVMPSVRTLPSFAFGDLGSRAGGFITDRFLTGLRPQEYFFHCMSGREGLVDTCVKTAKSGYLQRCILKSMEDVICCYDSTVRSADGTIIQFAYGEDGIDVQKSAYIDRPDDIINNAPLIKVDQHDEPPLKFEKLIKSFMDSKYTAPETHATLYQHYKRSHCEPGEAVGCVAGQSIGEPATQMTLNTFHLAGHGATNVTLGIPRLVEILQTTGNASTPYFSAPLLGDTDEEMAQNAQLAINSLRTVPLTDVIHSVAVEEGVYVDANGTKFYEYEASVQFENLATFQRAVESIRAFDILRITAHCLLNGFLKKVTGLMIVTMDSNVPYEITENTDYLHDCWRRLVLQEQAHKKDKLSERIRKMALNTGGSSSAGLGGSSARMAMYAGEGVEIVGSSKKRGDDDDKDGVGESQDDDANEDVATAAADTAEDDSDQEKTSDHEDSDPESQDEAEDGPNADEESVSSDDDDESQTLLADVGDAEVSSNTTASRDSEVDTPKASKSNARSKGFASSKPAELRSDASAGGESYRGFESDIKVGKQSITSLNAKVFQFAKSLRYCQDTGRMVLKFGWPFSKCPYHLNLLPLLQQEISAQILRNTPGVRQARVVCNTQNGREVYNLHCDGNNLQRLFLLKDNLVDFNRIQVNDIGTVLRYYGVEAARACIVSELQKVFSVYGINVDYRHLSLIADFMTNKGDIRTFNRYGMARHCSPLLQMSFESTMKFIMDACERGGYDNLGTPAGSIIAGRPIMLGGGLCKVLPRIDLRSRADSVSHSLSSAYDYQMSASRRLGVNSFVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0T2</accession>
    <name>A0A061D0T2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766434.1">
        <property type="nucleotide sequence ID" value="XM_012910980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0T2"/>
    <dbReference type="GeneID" id="24562789"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105570"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="78" mass="9014" checksum="5AE95AA4A93F821F" modified="2014-09-03" version="1">MFENLLYRKSENIQPILTQMQDVIATIKKPFLDDRSNVFGALKVAISVVEGHMARDGECRLLSERYHDIQPISSFIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1F8</accession>
    <name>A0A061D1F8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription factor TFIIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0102770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766138.1">
        <property type="nucleotide sequence ID" value="XM_012910684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1F8"/>
    <dbReference type="STRING" id="5866.A0A061D1F8"/>
    <dbReference type="GeneID" id="24562493"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102770"/>
    <dbReference type="OMA" id="DHDQRMK"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="324" mass="35830" checksum="D6CE33B789F87B6E" modified="2014-09-03" version="1">MSTAISARDKALARRKKLQCVDCGDAGVIVIDHTEGNQICVNCGRVAESVLISDQQEWRNFSSESTGGRGNERSRVGEVNDVWMDGGNSTTFIGGSRKMQHIQNLVGNFESTDRYLKSAFTMLRHVGDIINVNDVVLDRGKEIMKELNDLNQLKGRCNGLNTLAVIYMASREVGVCRTLKEMVVYDSKISQKDLGRAINRLKRILPMRGNAMVEDTAQLIPRLCSRLKINSRAAALCEYAAGKATIILRTSHRTTSLAAAIIYFVTQVAWSPVFGNKVPEIAEICMVCGTCESTIKATYKELLKITHRILPPNFNRETGDSGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1H4</accession>
    <name>A0A061D1H4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EXS family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0102950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766158.1">
        <property type="nucleotide sequence ID" value="XM_012910704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1H4"/>
    <dbReference type="STRING" id="5866.A0A061D1H4"/>
    <dbReference type="GeneID" id="24562513"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102950"/>
    <dbReference type="OMA" id="WCQNYLE"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="660"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR93972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="867" mass="99917" checksum="9BF17B95FE169821" modified="2014-09-03" version="1">MKFGAKLQTFVVPEWQDKYIRYKELVRLLKRASRLRSANIPGVEDDEERSLLHNLFTIDAQVVTPAFITSAGSADFSSKTEFIEEAPARSQSAGHIVNRSDHCVINIDESELIDTKLFAGASSESFVPSNPRIATQKSHTWPREDTIFRIADQYEREGTFSTSGFRTTPETDSRLNVALHNLDRVASVFEGDTRSNTQPCEHNDQYSTPVRKVVSAIVHRQLPYRSAVVYGHGDDATSPSNKDGCAAGNRRSHVTRHRLLTDSRRLSSKVRFCFSIKGFRICTSGIPRPRFNLKKNTPQMQDECLSVFDKVLRDDIRVVVSHYVTEMDYIKSLISFLKADIRRRGSQLDGSYAGLIRKACTAFWDAVDKLQFYLNLNTLAVFKVLKKKDKLMATGDIFNLYPTYKSIMLSLDNSRGILDDVAQMYNSLMEVPVIEFGVLKSDMESTLDSLRPKPAHGLFFIYGLCTVLMANSLFLCSFEFPLPFDTKILSSQIAAFRFFFVVSLIWFGFGWCQNYLESYGVNYQFQFGISSNYSATEKDYYLMGALQTLSCLMLFVFFLLDCKLHVVPTHHMYCFYPVLLILSHVVTVTWPNRNLKLKLRKRLFICLLRVVGAPFGAGDKVTLSDSIIADVLTSLTRPLRDLVCMITYFAIGVTSDHKVVSPVVQNWIVPFVMCYPYVIRFSQCLRRYINEKRLLHIGNMMKYVSGMLCVVVSSIDWVAIFQMRAWVRYLVVISCYVIATLYQCWWDYVVDWGLNIGWNIFRTRQNRMMYRRNAYYMAVVFNMLCRCTWALTTIPFTILHDKDLSSDIIFLIVSVIEIVRRVVWVTFRLESEHLLNSYKYRTALWVPKLYNCKNLIVKEMKMLNEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1T5</accession>
    <name>A0A061D1T5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MORN repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0104005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766278.1">
        <property type="nucleotide sequence ID" value="XM_012910824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1T5"/>
    <dbReference type="STRING" id="5866.A0A061D1T5"/>
    <dbReference type="GeneID" id="24562633"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104005"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104005"/>
    <dbReference type="OMA" id="EEYYLFF"/>
    <dbReference type="OrthoDB" id="365384at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31165" checksum="A2B17DD0AF865A3E" modified="2014-09-03" version="1">MGQVQSVSSSSFQEEYYLFFDEKQREEEPSSAAKRCEHFYGKSLPKTVSASGVSEVGSDPRLVRRGHGGDVFNVSTNSGVVHCGDLYSIGNTASLDEDMDGSANLGWSVDDCQGEFDCTLREYRSPSGRRISGRYNGEEFVDGRIVWPDGREYEGALKGSVPHGFGTYRTSTGKEYKGNWHLGLQHGTGCYVTDREGCRVSRHGIWETGQLVRWLDEDEQGEGTADSVRRSLLDKIMATPTTTPELSPSSREQTPISYSAKPRAAQPRAFRAACSGEDPGVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1V4</accession>
    <name>A0A061D1V4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766804.1">
        <property type="nucleotide sequence ID" value="XM_012911350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1V4"/>
    <dbReference type="GeneID" id="24563159"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109160"/>
    <dbReference type="OMA" id="IASDFMY"/>
    <dbReference type="OrthoDB" id="364825at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="300" mass="34386" checksum="DF2B4D78B7E3D688" modified="2014-09-03" version="1">MYDPQRKRDTLAEFRIHCDLMTDEFTSEFCNLDPKRQSQVLRQLNGRIKRVDMTQLLWLRRSCAMPCVDMIYILIAILVGWTNKDNESTVGTAPLIASDFMYNTLTDRMSQESFYDKVIMTQLKQKTYQLVVDTYDAISACKIKSRVFGTHKVLFATLFPKHAVEHIDELRFLGFMISSLHSRGNSDEGFCRVLVFVRNPDAEETLAYGYSPEVSGNFPDIWPLVFSSIAHDDTTFVFDVFRPTCLDIRSDDVESAKNRIADRLRIALEAKQVSYFASNDVHSDEEASFVGSDEGTEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D204</accession>
    <name>A0A061D204_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766338.1">
        <property type="nucleotide sequence ID" value="XM_012910884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D204"/>
    <dbReference type="GeneID" id="24562693"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104610"/>
    <dbReference type="OMA" id="AHAQIMK"/>
    <dbReference type="OrthoDB" id="360385at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1136" mass="128171" checksum="03C69E6EDBFD2A7B" modified="2014-09-03" version="1">MDMLDQDSEACLEWFRPWLESIAASESPRSSTWDENIPHYTKLQNAASLNEIAIELYHEIHKGDLSLQELTQHIGQIGDVLNQVDLRQLATQPKSRSNKMLTAFLDSSDISDALQECHQQDSYAYVYLLVRLLYEVLLYTKSTSVRLFCFYQIVRNTKVMRILFGLFTREVCIRGAEGYVEGKTPAVVDALDTIGQLPRQFSVNVMDTILMQMLEAHDINLKVCGFELLKLCPRIVACNPQLLGELRDALVGPVDDFATKSAVALIGVLEYVPKEVAQIFLRCSHEHTLAVECSPQRVQSFCCVALGCRLQPLYKTAFRMCWNIWIHIESCREQRQTSETLIVRESQFYLMLTSTILCLDRPDLEMRQRRRLESLFYDQRERESGMEVALCLNLLYKHYADVKELTKLCKMEVKGTNVYKDMNCILFKMIIRQFKESKSSKTFVNAVALFESLVFTDAANIKLLRDIKDAFKHLKANYSEYMLRILRVAATQYPALTGELSYLQTIVLRMMANIIKMCYVVEPQKLARMMPEIKEVVELTDLRFLFKPLLSTEDFGTLDDGLTATQVNLWVGTLYDLTHIKPPKIHNFVTVPVTIDLLTGKLRNVGETGPVRVTVITKKDGFNSSVLHGHVRSLFVDGFERIGSGGVMGLAINLALRLGLYDEAANYLRQLELWTSETLLWFHALHLYAKAEIESDEIKAVQLRVQCLDALETYSHQCTSWAVGDSKNDVMAPELNYNVPGLVTHVWCVLRLVFQVAVGHLQQALNESPYGPTALAPVFVGLFGHFKTLRWAFRDLCCETTHILQVYEGLCILLHAICSVEPAPEVKKEEAGSQNPEDSQHNTDPDEALRNYITNLFSEDDVHMPETFAIVELIDPAIRAQLYAAPAIMAAHKTLIGAVTKPCSDVAAAKVEPAVPQVMPTHVSQLSLESVLKEFVLFSRVRTNKEKNSTRKSTVSDDSNAVAATQCDAFVSYLSRDMDPLAPLLLLAKTCDTHNKNAKAVEELLKAIRALQLPMPVGVIKTFPLPFAALTALVVYEQRSGDGPAAVHIQGSMRNCACRVAWIKIKLEVLDDGASSPVIFRKRFKMHRNVIDKYVHLYLDLQYVEALSFSCLPLNSGGYPCGVPTHFRPTLREIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D209</accession>
    <name>A0A061D209_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766343.1">
        <property type="nucleotide sequence ID" value="XM_012910889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D209"/>
    <dbReference type="GeneID" id="24562698"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104660"/>
    <dbReference type="OrthoDB" id="365538at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="353" mass="38812" checksum="CB68215F57A664AD" modified="2014-09-03" version="1">MVMDTSNIPNLGVETQPVGTRNGADYLKKRISTSTSRAMAEDGAWQIRCIAGALSNSRGAFPENLTYEINGGVLIWIARGYQSELKVRCKNALEVVDGFYYAEYFLDTSKILDEHGEFQASLTVEASEPEYEPKAMVSQQTIVETVMRMKRQRQMRAKLKESEEGTPETQNGDATADENHPDAFEASSADPSSGQNTTQPAEEQESKTACPASVCVRVMNNTRNVYGKTVENLSAAPKKEAARFIKSNSASPRTRSDVFNTAVIKRDVRLVDVSSAHNKRKKHTRMLENPTSSKPIFELAETEGQSGDPTHLVSTLGVAEASRKTALLQNCLVSIAKNECVGETFVKVNKIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D288</accession>
    <name>A0A061D288_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger double-stranded RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767052.1">
        <property type="nucleotide sequence ID" value="XM_012911598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D288"/>
    <dbReference type="GeneID" id="24563407"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200230"/>
    <dbReference type="OMA" id="ENSIDKH"/>
    <dbReference type="OrthoDB" id="10568507at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17681" checksum="A5F5E6D345172D23" modified="2014-09-03" version="1">MFKRAYVYACTAPLPEADTAEETDYAVLTEIAAHLQSERTQKPSKRRNVETVESDETAEQSQKDDDLIVYMTGGKVAKCKVCKGKTMLNEDAVKKHLDSKAHKKNRKKGEKEALEAEEVRRRFMMRMESLERRTKQNDRKRDKRADADEAQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Q2</accession>
    <name>A0A061D2Q2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0202130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767242.1">
        <property type="nucleotide sequence ID" value="XM_012911788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Q2"/>
    <dbReference type="STRING" id="5866.A0A061D2Q2"/>
    <dbReference type="GeneID" id="24563597"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202130"/>
    <dbReference type="OMA" id="HRQTDHL"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="35"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="237" mass="26594" checksum="831D7C6302A3E94E" modified="2014-09-03" version="1">MRAFRVRNPATTHSAEWIRRQITDRYTLQAQVDNYRSRAAYKLQELDDRFLLLRKSQVVVELGCYPGGWSQVCLERTLAGASDARVIGVDRLQMDPMPNFTFIKGDITDETTHAHLLSAMGGAKADVVLSDLAPACTGVKQDDHLNSTELCMQAAQLMERLIAVGGAFVVKIFMGGQLTNYRTYLQSQFKTVHSAKPKACRSESKEMYFVCKGFLGARNLRSDVQTRGSFYPKEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2U0</accession>
    <name>A0A061D2U0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767277.1">
        <property type="nucleotide sequence ID" value="XM_012911823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2U0"/>
    <dbReference type="STRING" id="5866.A0A061D2U0"/>
    <dbReference type="GeneID" id="24563632"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202480"/>
    <dbReference type="OrthoDB" id="366767at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050189">
        <property type="entry name" value="MFS_Efflux_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124:SF3">
        <property type="entry name" value="CHLORAMPHENICOL EFFLUX PUMP RV0191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124">
        <property type="entry name" value="PURINE EFFLUX PUMP PBUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="172" mass="19151" checksum="15FB03F329CED158" modified="2014-09-03" version="1">MADSETQNSQTKKQPEKTYEGFARILYNFVSLVEGYDQQMLPMCMRAFEITLGVSQSQLSTMATMSTMSQLGCCLIWGILVDNNDPQYVLAAGLLVVGMASILLSTASHYKVILFLRFLHGFAFACIYPSQQRIVSDSQDESKFSMATTAGVRLMLCWDICGSWLVSPLHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Y3</accession>
    <name>A0A061D2Y3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766638.1">
        <property type="nucleotide sequence ID" value="XM_012911184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Y3"/>
    <dbReference type="GeneID" id="24562993"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107500"/>
    <dbReference type="OrthoDB" id="10412911at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="28500" checksum="91589E8729154D39" modified="2014-09-03" version="1">MVYYSLTEVPRDLREGIDWLLAVKGTDGHGLKELIAAVYRFLYRQPVGLIRLTPIEDIKRIFKKFLEQRALKDKAFAGAMLKRLKTPMEKNPNATLKVLKGIKDSDHMTLKTRGVTYDSMANDFNTLVDSLEKFLDDIKNPDQYRSYYSSEATWSDSCSERPEDCAMIFVGIAPILYVGMQAMFDASSNGVVGLKMFRAKDHLERVLFALGYVEPEIRANMSSADLRSALGVMNKAVMNTIYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D322</accession>
    <name>A0A061D322_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BolA-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767352.1">
        <property type="nucleotide sequence ID" value="XM_012911898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D322"/>
    <dbReference type="STRING" id="5866.A0A061D322"/>
    <dbReference type="GeneID" id="24563707"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203230"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="9633" checksum="DD2E7A50B13070FD" modified="2014-09-03" version="1">MITKAVVEERLRALLAPVFLKVVDNSGGCGAAFHAYIVSQQFSGKRLLERHRLVNGAIAEEMPHIHAFTMQCLTPDEWEAKDRPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3H1</accession>
    <name>A0A061D3H1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766813.1">
        <property type="nucleotide sequence ID" value="XM_012911359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3H1"/>
    <dbReference type="GeneID" id="24563168"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109250"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="62" mass="7260" checksum="F35E91CC69D28BF4" modified="2014-09-03" version="1">MLQVFLLRLGALRIRSHFTRSRGSHLIDVKVLLTLSRNMPSLYDIDYFDDEELPQTSKILVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D418</accession>
    <name>A0A061D418_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribokinase like superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765910.1">
        <property type="nucleotide sequence ID" value="XM_012910456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D418"/>
    <dbReference type="STRING" id="5866.A0A061D418"/>
    <dbReference type="GeneID" id="24562265"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100530"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052700">
        <property type="entry name" value="Carb_kinase_PfkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320:SF3">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600585" evidence="4">
        <location>
            <begin position="22"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="5">
        <location>
            <begin position="95"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="367" mass="40189" checksum="FE0C92F3807BC179" modified="2014-09-03" version="1">MNGSYLFAAFAALVAVASAAAHDRNLTGKEMVEKGSPRLLFAGNASLDLFAAVDESVIKSLDKSKARPKGITMKSIKKVADKILIDTKTPTEPSANAARAYAYCGGKAAYFGVLGKDDLADEFDNYLTYNGVEMKTIRRPDMHTSRLYALATPDGMYNKYYLPGAAETLTVDDLDESIMDKFDFYVVNGFMLGSPATVEFTNKMVDAALSRGKKIITLFANTVCVKKYGDLLKPIAEKSAYLSGNLEEYLRLYNFDTAEELFEYFEDLTSVKKLQHKTVIITMGTNGAVIIFRGRRFEIPATGVTLINTTGAGDFFAGAMLYGLLNGYSIYQAGEFARAIVGDVLSKMSRRIGDGIRHQINHIKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4C5</accession>
    <name>A0A061D4C5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0200590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767088.1">
        <property type="nucleotide sequence ID" value="XM_012911634.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D4C5"/>
    <dbReference type="GeneID" id="24563443"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200590"/>
    <dbReference type="OrthoDB" id="366326at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="613"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="813"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="985"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="372"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="449"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1136"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1190"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1194"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1217"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1238"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1275"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR94902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1353" mass="149458" checksum="8C3F07BC7A18A1FA" modified="2014-09-03" version="1">MHKKTGSGDKANVFNKDRGHVLDMVESHMGSQFTQDSADTFVGSKKVPKVTLPLPDSALIKGAAVPECDDVANESKVIRLRTGSFGNKHTIDDHLDVEEVQDLGSSTHKGSDSSAKTDIDDIASAMDDMMGIDIDTAIDVGDDADLDKATVYSSKPWGDETLKSHASSITVVDLDVVDDVAENVTHATNDSTSRLGVDEEAHDFGVNASDEKLDEGPIKPSARKWSIESTAESICATDGAQSNAESRRHSLSLESKSSHSPKIESPDESQSRKPLRRRSISSNGYKSDSSVITEAVSFFAVKHLVALLREVAECLNAGEDAEERWEHVLGMQSRAQRFINEAVRVNFEYDDLSQYQLVLPKKLNLNYAMPKTRTPQNDLLSQQSKPKTPVVRRNTQPDTRIVSTTERSDKPLSVTPVPSNMESTKVLVVDDSIPMDVDIDAEIERFITQQTHQQARQQEDPVNAATPVESDTESHSFPKIRTMNELKLSKEQERNAKRAKTANAESQSKKKTKKSEDLFDDEEEDIYGTEDFEQDAAGDISHLSDPLSEARKIYMEKVNSCEIDGMDLRVPKEVLQSNMQLFREQFEFSQKVNDVNTRVFGYSSFRGVQLAAINAVLLGRDCFLMMATGGGKSHCYQLPSLLLGGVVVVFSPLISLMEDQMRVLRSYGITADTINAGTSAATTRQIAKRYLDKQQEFENGSILFITPEKFEKSAVLLKLLDDLCDSERLKLFVIDEAHCVSQWGLSFRKDYRQLCNLKEKYPYVPILAMTATATEDVATDIMRVLRIPRCVKLRTTINRPNLWIECREKTKDYLKEMTDILKTTTGCGIVYTLTVGDSEKVAEALQKAGISAGVYHARLDINDRKEIQQKWTSGVVRVMVATIAFGMGIDKPDVRFVFHTSAPVSILGYYQEIGRAGRDGKYSTTILWYNMRDFERHKNLGHKTPKTKGIPGEEIADYPSLSNMREFCQNKSTCRRLMLFRAFGEDPTGVLPDNCNGCDNCCLSCMTERVDATDDAVTICKFVHETMERRTKGILTINILCDALRGSNRSTLIKYRLQQNSNHGALKHCKPKYIFQVIQEMVNLRILRECRRSSNRFGRTVLLLGPGAGKLRRGQISVYIINYQFAQNPAPAGIDAPDATCQVEQPTTSGAKKSQRSQKATAQESGEAKTTSPTLKGVAVAKIVEALKAASAPGRHDVERADTHEKRPVVQGMALTRDNQFSLVSQGTRAPGDVRRGSPTSAAVTNPATDTAETVKRKRGRPAGSTKQKSKSEQQDTSSSINGSSVNQQKAGGSNTPPGLVTSDAGGATWRHANTRALKLTPPGCPNSSVDIQAALHNNIRRKVPPDLVSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4E6</accession>
    <name>A0A061D4E6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PA14 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0206110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767639.1">
        <property type="nucleotide sequence ID" value="XM_012912185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4E6"/>
    <dbReference type="STRING" id="5866.A0A061D4E6"/>
    <dbReference type="GeneID" id="24563994"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206110"/>
    <dbReference type="OMA" id="YYDNAYF"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.182.10">
        <property type="entry name" value="Toxin - Anthrax Protective Antigen,domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595783" evidence="2">
        <location>
            <begin position="42"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="255"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="860" mass="93977" checksum="6CF69754B183CA0C" modified="2014-09-03" version="1">MALSCESGVWRGVAGRCAAAALRLLAALLLCRCCLLPLAAGTLDVDKNVGAPKELTIVSATEYDREELQKLTEFRQRHRKTVDGMLCAAAFVRNGKTFTDCTTSEAPDGSVGREWCYVEVQLVGVGFRDWDFCAGVVDYDVLRSKATLLSQLKASELAHSVLQLSSEESRLTRTLSHFHEVCGRGAESHEIELHELSHALHGLERALQQVKANSRTLQTLTEQHEALEERLAIARKNALNDKRNCAFVQGYTPAAVGDGIRASYFDNPYFRGPPVGFFDHPHLAVTFDEVLPVGGVDIRSFSVRFEGYLRAPVSDTYTIWVDADCNFRLFIDGELVVEHGLEGHAKFTAAFSPVGVVALDGRSTSSSHLASRKLLLDGGKRYPIVLEYSHQSVLKYRDEKVARISVSWGTATRPQAVIGGEHFFRSRESGEALVISGIEARLFDLAMLENGAQAFLHVTNLVVADVPDRFRGARMIRTVLRPDFDSVTFHISHDAVVYVALSAHASFIPTNAEDASLFERSSEVISVYGVGDNCEEALSQQEFVVYYRRVKAGVVKLQLLAETSFFIFLQPTMANIVCQDDLEFLPFKNGDQCAASSSSSAAFDCTKGFGGGHWRSGSSRSSAQWLTRTFANPVELSYFHFSALDGSGPMRARVVFPDGAAEEFELQSQLRYDLGYHGVIDSLRIEIESANTGDSVEAGESDWTLGGTFALYGRQCGSKTVVEDAIRFPIHIDFCQANESCGSQYVDLGHAKGAHGRLSYGWGATNIITALGDVPFCTSRYHTATAEGGIDSSSQTAFGRMLKGRSGLPLGSGQWWTLDVPEHGVYIVEVLLAALCTHVQSASLQLNGVEVLEVSAVSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4E8</accession>
    <name>A0A061D4E8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periodic tryptophan protein 2-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767113.1">
        <property type="nucleotide sequence ID" value="XM_012911659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4E8"/>
    <dbReference type="STRING" id="5866.A0A061D4E8"/>
    <dbReference type="GeneID" id="24563468"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200840"/>
    <dbReference type="OMA" id="VYEWQSE"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="454"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="988" mass="107161" checksum="65B1C280F146EDD8" modified="2014-09-03" version="1">MSAYTLADICGAPYTGGRICFSPDGGCILAPVGNRITVYDLQTSKSTTLSSQTRSDIAIVSYHPTLPLAILIDCHGYGYILNLLRDRILHRLQFKSSSTVATAKNKASILPANESQRLVRDAAFSPDARFFAVAVGRKLCIWRAPEEHLSWRMTLHRELTGHMDAISSIDWSSDSRFICTASADMTVRLWSVNPIEGFVPCAFVDHRRSVKGAFFSRDMGRIFAVSKEGVIIVWKAADEGSPENANAAKPIGRNKARARKASAEGGAEAAATSGAAVDIATAVWVKETQAYCNQAKNTVVSRVSFNKNTNLVVIGFTGGLFGLYKFPTLDSIYTLRIGNELPVVDSVDVSTDGDWLGLACSETGTIVVWEWKSETFVMKQQGHHSGVRCVAFSTGGGDAIKLGGVVDKELRTDVDQNYSGNNLGLGSRYVVATGGFDGKVKLWDSNSGLCFVTFDEHTASVEAVCFTPQANAVITASLDGTVRAFDLLRYRNFRTLTASRVQFISVACDSSGSIVCAGSRGDANSVFIWSLQSGKLLDELHGHSSAVTSVAFHPSLAFSGFLVSASWDKFINVWNIYGRADKGGATEPLLNSSSVVAIAFDPRDNNILAAAVLCGNILFWDLDNSEQIGSIDGLRDLQTGRDPTEFFAANNSRGVRGHKGDLQAGLNRNQHFNSIAYASSGRMLIAGSRNSAHVCVYNTESYSLLYSLTLTRNRSFTGINRELNSRYMTEYGSSLQEWDLSDDEEVAEGAAERRRIQSHYALPGVQQGELSRKSRRFHVWCVSCAPDGRQFAAATSHGLYVYSVDAYIKTPNYVNEVLKSVGSFQPQLLTKNVTTGNVLSALEAGEYSRAFVLALALNDFNTLLRCYESVPIGSIGQVVASVAPEFVCVCLNFIRAVLSPDSPCGTVHLQWHLLWLEEIFSIHMHTLGGLDGSGGAKSIAPVGQMDMRTMLLLLLRQLRQTKATVSGVLSSNAHTVGYLASLAGRNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4H7</accession>
    <name>A0A061D4H7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767817.1">
        <property type="nucleotide sequence ID" value="XM_012912363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4H7"/>
    <dbReference type="GeneID" id="24564172"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207850"/>
    <dbReference type="OrthoDB" id="366552at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="238" mass="26455" checksum="96B42EBD62EC3C13" modified="2014-09-03" version="1">MAHNSLTDAPRNFREGIDWLLALKGRYPDESLKGMGEAVYQLFKSDNVSVEASTALQNVHDICKTFLDKEGLNEQFFVKEFLHRLARPMNKKPGALDESPEVSASSVTKDLVHVVGRCEKFLKKSKLYKQYPDAYTRSATWNSSCAQNPEACAVVLVGIAPMLYTGLRSLQVASAGALEDESDSAAKERMGEVLKAVGFDDSECPASNRNAPVHRALRRVDERVFTILHNLAGFWVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Y8</accession>
    <name>A0A061D4Y8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor, arginine/serine-rich 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0202690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767298.1">
        <property type="nucleotide sequence ID" value="XM_012911844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Y8"/>
    <dbReference type="STRING" id="5866.A0A061D4Y8"/>
    <dbReference type="GeneID" id="24563653"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202690"/>
    <dbReference type="OMA" id="PREPAYP"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000623">
        <property type="entry name" value="Splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="239" mass="27533" checksum="73C5D7B841D2A9A3" modified="2014-09-03" version="1">MGGAEESARVYVGNLPDTCSPKDVEAEFQKFGKLTSCELKKNVGGAAFAFLEFEDPRDARDAIKEKDGADFLGKRLRVETPFGSKDDGRGNRRRGPGPPRRGRYLIEVTGLPPSGSWQDLKDHMREAGECAHADVFRGGVGEVSFYSRSDMEYAIDKFDGSTFKSHEGEKAKIRVREWRPNYRSRSRSGSHHRRRRSHGRERERSRRSPYSRGRSIDRSREREREHRHRSRSDSYGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D511</accession>
    <name>A0A061D511_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0202890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767318.1">
        <property type="nucleotide sequence ID" value="XM_012911864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D511"/>
    <dbReference type="STRING" id="5866.A0A061D511"/>
    <dbReference type="GeneID" id="24563673"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202890"/>
    <dbReference type="OMA" id="MPCDKCE"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="10301" checksum="000BF88ED734C1C7" modified="2014-09-03" version="1">MPCAKCEKKLCKLATPDTKRDGNRCAVGVNKLVEKRIKKDKVEPNKDQCKNCKAFLHIKGKYCNVCAYKQGRCHMCGKKMVDVSKHLMSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D593</accession>
    <name>A0A061D593_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LamG-like jellyroll fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0210040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768037.1">
        <property type="nucleotide sequence ID" value="XM_012912583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D593"/>
    <dbReference type="GeneID" id="24564392"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210040"/>
    <dbReference type="OMA" id="NNHMHKL"/>
    <dbReference type="OrthoDB" id="9987655at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058332">
        <property type="entry name" value="DUF8019"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42535:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_146, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42535">
        <property type="entry name" value="OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26058">
        <property type="entry name" value="DUF8019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600064" description="LamG-like jellyroll fold domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="LamG-like jellyroll fold" evidence="4">
        <location>
            <begin position="140"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="357" mass="38316" checksum="456869908DC970C8" modified="2014-09-03" version="1">MAGVTYYHIVCGCVAVVASVTLSLVLAADVAVESTPAVSTTSHTYLERLVKRVSGSFASCFEVGNAICLGKQVITTRAPERGLVAFWTFDKLYPIDESGYGNHIVDHVTAGPPSTGHGSSATFDEDTGCRVVASPSLEVAEFTLNLRLYLLDSNSLGFRNVVSRRSYSAQSPTVMLYPLSNKLSVRVSTENSANEGLTSNAAIPMRRWTQLTVVAKGKTLKLYVNGMLDSAIALRGELVPGSGDLYLGRKFDTPGFNGYLDDVKLYNYALGPGLVAAFANPSLTGFGAPFRVQLASTRCTLQEANANGFCAPGCRLCTLDQLYRSAAHRGGVRTVAKRTRQVQSALHGRRLIFPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5A0</accession>
    <name>A0A061D5A0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0208920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767924.1">
        <property type="nucleotide sequence ID" value="XM_012912470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5A0"/>
    <dbReference type="STRING" id="5866.A0A061D5A0"/>
    <dbReference type="GeneID" id="24564279"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208920"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF82">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="177"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR95738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="514" mass="55125" checksum="7DC186B10E55A893" modified="2014-09-03" version="1">MSSLLRSFGSRVGRSFGRTLSPCRRSFSAQPAAAGLQQKGSISQVIGAIVDVKFDGAPPPILNALWVETPEGRLSLEVAQHLGNGVARTIAMSATEGLTRGQEVVDSGNPITVPVGEATLGRIMNVTGDALDGCGPISDSKRLSIHREAVSFSDQRTDEALLITGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKKHGGFSVFAGVGERTREGNELYHEMMETGVIKRRQLEDGTFDFSGSKAALVYGQMNEPPGARARVALTGLTVAEYFRDEDGQDVLLFIDNIYRFTQAGSEVSALLGRIPSAVGYQPTLATDLGALQERITTTNKGSITSVQAVYVPADDITDPAPATTFTHLDATTVLSRSIAELGIYPAVDPLDSTSRMLSANIVGEEQYNVARGVQKILQDYKSLQDIIAILGMDELSEQDKFVVARARKVQRFLSQPFQVAEVFTGKPGRFVELQDTISGVKEILDGECDDMPEMAFYMVGGLQEAKEKAAEMNRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5X3</accession>
    <name>A0A061D5X3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="5 12 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0211100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5 12 14"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768149.1">
        <property type="nucleotide sequence ID" value="XM_012912695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5X3"/>
    <dbReference type="STRING" id="5866.A0A061D5X3"/>
    <dbReference type="GeneID" id="24564504"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211100"/>
    <dbReference type="OMA" id="ADDFHPK"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000032">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7 12 14" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 12 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="177"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR95963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="473" mass="52312" checksum="9DC01D9863A3EDD6" modified="2014-09-03" version="1">MGKPSFEMTSEFGVIGLGVMGSAYTQNLASRGIPVAAWSIQQHETQKMMEQNIPNLQLFSSLPDFVKSLKRPRKIIMLITAGKAVDQTIDSLIGLLREGDILLDGGNEWYENTVRRLARCAERGIHYCGVGISGGERGARESPCMMFGGQPEDYEAVRPFIEQEPGRSFYVGPGASGHYVKMVHNGIEYAIMQVLSEVYMIMRDIFELQLDSIHQILAEWDQGDVGSFLLGITANILQVKASDGVTYLVDKIVDSSGANGTGKWTVKEALDLGVPVPTITTAVEMRHASNSFRSTVVMSNKKIKEGHSISEGDLRRTLFGCIIVCFAQGISLLMKASENFGWGLDMGKICRIWSSEFAIITPLTRAEDAIISCKLLEPISEAFEENETLANLLEHPDIRAKIGDSVESWRKVCKACLNYNLSAPAIIASLQYIQTMSSMNLGHNLIQAQRDYFGAHCFTRNDGPGKHHYNWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6G6</accession>
    <name>A0A061D6G6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase, AAA family domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0300530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768334.1">
        <property type="nucleotide sequence ID" value="XM_012912880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6G6"/>
    <dbReference type="STRING" id="5866.A0A061D6G6"/>
    <dbReference type="GeneID" id="24564689"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300530"/>
    <dbReference type="OMA" id="YNICEAD"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001054">
        <property type="entry name" value="ATPase, AAA family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="434"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="681" mass="73748" checksum="9BBCC3C954802127" modified="2014-09-03" version="1">MENVAIKLAAAAARERIPVEYAARYTDLLLEESRNRNDSNADSYHADTIHDTVSDFLLQFEEKIALNLDATVAELRPDLSNVQHRRNRYTSIYDSSTSDSAVLTGASSITGSRRQCLKSFFDGKSFVGSIPLKNAARRYILGELELDAVRNIARLSGLRARQTRVAASNAVGAQNGAVSTPATATPSVAPASRDASTNVATASQPTSKSTESRVSGGVANAVPPEASPVISRPEIKPTPKAAQPKQDPPAYLNTKKEISESHGATKDDEPNPSGTVKRQWEAGATKAATDGTRLAAKNTKRTNNTDPGFKSGMDVLVNDCEEKKAPLNIGSDKPRQSCGLSYPSKTNLNSLVTSGNTNQSSKQKPPVDERYVPLVGADLTPEIINVVLNMKLDASLYNICEADIAGLNEVKKTLKDKVVQPIMRPDLHTGLLRAPKGVLLFGPPGTGKTTLAKWIANLSRANCFEVSPSSITSKFHGESESIIKALFKVAHFDSPSIIFIDEVDAVLGKRSTNEADLSIRMKNQLLQMMDGLHCGTNDGTVVVIAATNRPMMLDDAALRRFGKRVLIPLPDLETRKAFLHDTLRKNCNGNCELSSDELDQIAASTEGWNGSDLLALCTKAAEYSYDDTVEAYGGIENIPDASVFRGLVIDDFIRALRRVRPSNAASSDFSFEEWQRLYGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6M1</accession>
    <name>A0A061D6M1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-tRNA hydrolase ICT1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768507.1">
        <property type="nucleotide sequence ID" value="XM_012913053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6M1"/>
    <dbReference type="STRING" id="5866.A0A061D6M1"/>
    <dbReference type="GeneID" id="24564862"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302250"/>
    <dbReference type="OMA" id="NVDTAKW"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="19231" checksum="1245995F3A51D15E" modified="2014-09-03" version="1">MLRAINDVLRISQRRIATGVPINKIKLTSSRSSGPGGQSVNKSETKVQARFNVEHDWWLPPEVRDKFRTPKIRQLHKNKITRTGDFVVESDEHSSQEQNRKACIEKIKAAIRQAEQYEPEEKLSFLEQIERDKTPKEIREYKQKRRESKRKLKQIGHKTMHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Q4</accession>
    <name>A0A061D6Q4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766810.1">
        <property type="nucleotide sequence ID" value="XM_012911356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Q4"/>
    <dbReference type="GeneID" id="24563165"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109220"/>
    <dbReference type="OrthoDB" id="2193044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="143" mass="16836" checksum="8AAFBEC4CCB18D8E" modified="2014-09-03" version="1">MNVTHMKYVIIIVEIGITNRDYLLDTDKFKKQKYEDLIEDLKARQFNQQTKIRVIPYVMTWEGIATKEHRKYRRDLGISDRMEAHIQRVVIQETHKIVMRDMKMKEDYDSVEDPQAQTGWMPAWMAPVTSGNGPAWIPQPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D729</accession>
    <name>A0A061D729_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Cell division protein metalloprotease FtsH, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0110270</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766915.1">
        <property type="nucleotide sequence ID" value="XM_012911461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D729"/>
    <dbReference type="STRING" id="5866.A0A061D729"/>
    <dbReference type="GeneID" id="24563270"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110270"/>
    <dbReference type="OMA" id="NNVEFAA"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="20" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 20" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="264"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR94729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="680" mass="73741" checksum="C734FFC7D7C5CC5B" modified="2014-09-03" version="1">MDGSGLRRGALPGHLYNERTFDEQGAVTDDDDDKMSMSRPFLGPTAPANRGAAPYGLATLISSSGMEAPSPEHDSGSPASLASNIGTTLASKWHLFRSTISGTIPSDTPKSDMATHYASDQSSSSLFGQAGGLVSFRSPSSLFSSTLSWLWRSSMTVLSVGQWLLLQVLGIAVGVILTGLIISAISGLLMGGDGEFGHVTPKERQEPKNTKAPPPPPPPSRPPVMLERVYFKDILGIDEAKEELTEVVKFIKHPKLYQDIGAKIPKGVLLVGPPGTGKTMLAKAVATEANIPFIYTSGPEFVEIFVGQGAQRVRNLFAKARKQAPCIVFVDEIDAIGAKRTSGAMSGQNREHDQTLNQLLVEMDGFNISTGITVLAATNRLEALDRALLRPGRFDRVVHIPLPSLDGREAILRRYLSDVKYDKEGVDIRALAKLTPGYSGADLKNLVNEAALICVRNGRTLVGTEDLQEARDKVGMGAKRRTSQPELQRRMTAYHEAGHALVAYHLYPNTDPIHKATIIHRGSALGFVEQLPEGERHSYKLAQMKARLAVCMGGRIAEELVFGRQNVTSGASSDITAASELAYRMVTEWGMSPRLGPVNLRRIGGIQTPHGTRKLSHDTAQVVEKEVERLVEEAHHVASSIIRRHRDQLERIAERLLEEETLTGEQIDKLIRGSGTSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D750</accession>
    <name>A0A061D750_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING finger protein 157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766930.1">
        <property type="nucleotide sequence ID" value="XM_012911476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D750"/>
    <dbReference type="STRING" id="5866.A0A061D750"/>
    <dbReference type="GeneID" id="24563285"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110420"/>
    <dbReference type="OMA" id="VYGMNDS"/>
    <dbReference type="OrthoDB" id="10261999at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="297" mass="32944" checksum="DE09E8FCF909C8C9" modified="2014-09-03" version="1">MGHAVSRVRHARLFARPELEEGSNPAPPQQIILEPEISNLTSFIVDAAATPKDFTEKPDLPVSRSSLEGIRSMGAAVAVLKSSITVHQFTLSFEYSSRAPATVSFLFQQKHQGLSNGIPSFSKAELRLGPYQLPVGDKLQYRLDRNDVLAHRRLTYEFSSFKDEPAFVPILLLFAAPANDYELFIMGGLAFSSTSNRWEFVTTKQRVRQGGVGYELQEVYGLNASAFSKSFNKADDVDTDSRCVVCLTNAKDTFVMPCRHMCMCSTCAAGMGNMYKSCPMCRTTISHIVHMSQMTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D751</accession>
    <name>A0A061D751_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768539.1">
        <property type="nucleotide sequence ID" value="XM_012913085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D751"/>
    <dbReference type="STRING" id="5866.A0A061D751"/>
    <dbReference type="GeneID" id="24564894"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302570"/>
    <dbReference type="OrthoDB" id="366771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595854" evidence="3">
        <location>
            <begin position="28"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113529" checksum="79174BFECD61FFB5" modified="2014-09-03" version="1">MVSTYQRFTLSWALLSSLLICCELVRAQLDPEDTNDRPISWRFDSSSVRPPLNPRNMEQRDEMQRVGAVADDAKRYIVIAEDALKIVFPQSSTNNFHVTKLLFDANYANNAVNVGRWENIRAMVKAITDGNNTIRNAGFHPAPVKTVKTGVFQSATVMQDFDGYQELISQININYLRKYLDNLISSSKLYMQLKMLKALPPYLLNEVEPFMLIRKLSTVYSITGVYNYTGLISEALKAFTDAESPESKEYKTWINHQRAQLKELAALLLTYDVDKAEEACSSLQCMGYTNSANVALWYELYSAIDEQTVLMRSSDELKTAIHLTLARRGNTYYDYCNLSKIACILSSLLPQRVMTQEERHEFEANMNRLRASMMAAGIKIDASAPTATDESIVDHFDPTTPINASRTELTLFIVYTKSMMRDTVKAQKWIRTHLYNVANGEIIPRESSGKDDWRTEFDRLRGTSDIIQEMIDASRVLNKESDVYIDRYLTSSANGYITEYGGNLILKKAHRVMSNTSAVRGLMLDFYARLNRTFVAREAQMKLYAYPSLLYEVANLVSTSCRALNAYLTPYMELIGAVTMDMAKADAALSSAPPSVSSSDRFEHMRARYQSLKDDVQLVLNQFGDLGVNAERILGLLRFVDGNAVSESEDSREQLWYSYFELREDIHNGILLGSAFESIRYKCEEISKFADELAALVDGDGGSGEASRRATAVPGESTEDSVSGDAASSDESAADGPVDAASVAGGEVVAPTEAEHGDADGSLAESDGRDGADEATGSVPSERAQEAVSASTNDHVTPEPTFGMPSEESYTTLPAYEEGVYEPATGVFRLSREDERTPIDGDVSTGTTAADRATESTTEKSAEELPRAFGGVEVPSGGTPGGEVPAMWGQSDGETPTDSSATREVTKASDSEIRKNAPTADQSSSEDPSGTETAAIASEVEVAGGAAVAGEVEVAGEAAVASEATVAGDDWADDDDISPSTPEASGRVTGVDEVPSEVIVLSGSVDERGNLRDKLSSGFGAVCVCVKAVLSLFLWAVMWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D772</accession>
    <name>A0A061D772_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768569.1">
        <property type="nucleotide sequence ID" value="XM_012913115.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564924"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302870"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2203"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2265" mass="254652" checksum="737DEAF209706A75" modified="2014-09-03" version="1">MAPKKLTDCPENLRESIDWLIQIKNCGDKKGLQNLADALGTLINQAIEDAQNSLKAEEEKLKCPIIYEGNLTYCQFNDRSLKEAEKKLEELKDKQDLESESQKQRLEKEIEQFKLSKEKCIQHTHPRYPDSKALKDVRAQLKASQELHEKLKPFLNNLQRTAKNPNDGILHNLCSGLETFLGFDAATKGYTGKGIVYSDLDRLCDAVMAFIVKCLKENKSLLMHYYSEIVDKIGLLEGSIGKGLSVEGLRRAIDTVRDGLEGYEGGMDVRIQNFLDNVKSLNNDLYVKVKTIESFTDKDFIKVSTSFRDSVEIAIRSIATLRDNEAGFKNIDKHLKGKLNISLEKIDERIKGLHNALQDDIFVKAVNTLQSTFDTLPDEVERFISNNVTGTISGHRDTVVDLKRKVKEHIDVSRDNFQVERLRVCKVDMEKAIATFRKNAKNLGGLRSDVVKKAIDEIEYTLKDEVDKVEDESALNSLKINPVGTQIGNITKEINRHCEGKCMGGLRGLEKSIGEPKKLFDTHHQRRLSELVKHAKTNIEKTLKCADEHAKYLGGLRNDAVVGAIKVIQEKLDEVNGGSYDIDTFVKLTNLKSQTVDVEVKKIQNVLNDGAETIIVGLRGLEGSIKKPEDLFNKHKDTLLEFAEEVQNDFQTAVSKAQECITRHGGMHNNKIMGAFNSIEKTLKGIETPNKNAEDLSQVVALVEGQLAQVNGAVRASAPTLQSTLTAEFTELKHKIGGVSTTLTDSELKSLITTTRLYIVDAICAIECHGTNTNGTKNNGAFAIVTALYGILGRLNEPFRDFITTLHITINSDLITLQDVNGAFKEQVKTSGTTTLLKSLNVGNLQPEFDKSRKAALKPLLDRVKNALTGAAEGVESMLLGMQSSHKDELGSALRNLKRPIESLNTTSKLMDFESQLGVVDAAFDKVRTQMSIPLFDQQILIHVQKSIAEIKRELRRTIITAQATAFQTAIDIARAEVGSVVQKAKTAIQTAESEYQLELNRLCANIDAAAQDLQNKASKHQIGDATAAIIKPFSNITNAITSKSVFSADIAERQQYFDNLQSQITNTIATIHEAYKNAYRSAAKSYLSGAIGSIKKAVGDAETAYGSAIDTHIKAIGGKVVHIKEEKFKVAAERNKLAMLFEESFRQLEAAVKEKSAFRKDLTGRTECFNNLKTLIEDTVNTLSTAYQKAYQSSAKTYLSNAISKIKENVNNAEWNYVDAINVEIKKVKETITGIQHIDFKEKATRDGLTERLTPVFKTLQEKVKTCCAFKTDFVNRATCFTSLENLINSAIAGIIHASETFDNCTSMAENYLTESFNDASIKITSLGNKIHDRIKQAFDKIILEVYTMYSKDKIAHMKALNTCIECMMQEFKSIIEEDKRTGMKGLLKALSGVNPNYTNPENRLEKLKDKPLAKELAQEVKSYLDSIFIYVWNDIYAVIGSQFTSKNLYKTKVEKIKNNLNELFNHLIVEKGKIYNYDHKFVDLLGNVKSVLINMYPQEFGATEYPVLDGIREGLNGFTEQLGYAYINKYVGSKPIEWHVDKQQTKLSQDATRCAKIFLTLIPEWHKHIPYLNRECNKGCTDKKISLQEQKMNSGITKIVTNPLGLWFDCRGYKVSGFDKQEGELRNNSGCTGNKIGENLKTFFDKKNTFGNLLYYLYEYYKVCHIKHIPSPKPPTTICQMLYWLCGLEYTPMYENMKTYLQEWYNDFKKEHEIEKALSATVPRRTGHEVVTDLNLGNLLGSYQNVTLRASDVLLTILGYGDADGRYACEFNTNPYNLYYPTDKSKCFDMLVEICLRLNHQLRFLYMQCHNGPRSSGWADCRYGKYIAGSAWNCNRLQCVEQGCDQNCKWHNDCGVKSPLQSFLEDGLKGFLPHQFSSPSCKLECSVKNHNGIPCKTPMGFADISITASWTRTGHDIKKVLDPFCGTLPDSLSLLCAYFLCLLRRPPQTLCDMFAFYENFFEHWSGHYDSVHKEQVKQHKHDAFKAVVASANFGVEYDGLDPTTMFRSSSHSGDDATHLKGDLFAIVNCKPNENPVHPCGSYLQPLSYEVRCVFTEKLAADYLSWIVYITETFYNLLNDLYNKCTKCCIQQQADCYGRICAKGCTVDSTPEPAESKMLTDKTHGELCNSIVQCAGIHPTIYAAGFTFGSPWSLCGDNGIGKKRSCKDFCTALGMVVAKYNAIYNLVNKHIPNFLWEIRHKFFYTLVALWAYSLLYLLYVIIGRLDTLHVRSHLRLPSSHKISAQSLLATARLNNLAKLAYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7A5</accession>
    <name>A0A061D7A5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768038.1">
        <property type="nucleotide sequence ID" value="XM_012912584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7A5"/>
    <dbReference type="GeneID" id="24564393"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210050"/>
    <dbReference type="OMA" id="WHVWDTM"/>
    <dbReference type="OrthoDB" id="360335at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="408" mass="45858" checksum="12DB1B8E89964180" modified="2014-09-03" version="1">MAAARIGDGRVAIQVAVADSYHVSGGPFCCFVRVAPVESQWSDDDTPVSVDFISLNVYGLVSFGSRLLAPSKIQNSLHFGFLKEARRRLKPNEGAHLICASDAVLFHTCTEIKRTSPESYCRSTPHPTDSGADRYTCTIPPFVPPTVDGENVSCNYFVDVTVQHSSNRLSLQRETLRRRLEFRVQGSIYPGVPTLDDALYPFLPKKGGYRLDGGRVDEAVLPRVCRDITSGDYGRENMFFDYDSTLVRLEAESPAVEITADRSTDASLLSRDLNAFWHVWDTMNGSGFLHEPEESYVLRRYNRFVEQFTELVLNDATGKELEKYRPWFGSMLQVMQPSGDQGPAGGGRHEALRKFYKVVEERIAQLQGTTMDNLRHAAGDSLEMQYEQAVDGKVVVQWRHLCQQVRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7G6</accession>
    <name>A0A061D7G6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768674.1">
        <property type="nucleotide sequence ID" value="XM_012913220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7G6"/>
    <dbReference type="GeneID" id="24565029"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303920"/>
    <dbReference type="OMA" id="RTSHEIE"/>
    <dbReference type="OrthoDB" id="364798at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54729" checksum="3BC872766F745350" modified="2014-09-03" version="1">MVLRLVRGTGGSNDARSGQSASGAGNERLTDFQREMILAEQHAENLRKRQRRNLLNEDFGPTVSIDANEEEDGLIEEDPLDMNNLNDIIEDTTTKADAAASDDVALFDEETDQQSLAPTSLVNKARVSKTRALHILEHPHCSKYLVGSLMRIWITPDAAPDSVSSQHPHLVNTHAIFKVERLVKTNEYVVYGDSVGNSCDHEIREFLGKTSYSILGRLMTDRRSDTLNKIGLNDVCSAPILQEEIKFGGEWLIRDLNQAATNLRNVSFPHGIFIMMQFTFTDEDVQLILERKLLKESVEQTEFQGGRSSLIAAIQRTSHEIELLTELVKNDTSKIDHLRALEARKAKMDEQLQTMKALTRNPLFIKTCPVLRANAEPSARGGAVRKTTQPTPMIMFNNIETQEIFPTEIRRRERKTVSEFSYEEQKELVIAYITVSISFTVICILLQNVDKCDPDQWLSPSDDVNAGNPGKPDQAGVISMKEYLNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7I5</accession>
    <name>A0A061D7I5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0210950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768133.1">
        <property type="nucleotide sequence ID" value="XM_012912679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7I5"/>
    <dbReference type="STRING" id="5866.A0A061D7I5"/>
    <dbReference type="GeneID" id="24564488"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210950"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="35"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="465" mass="50579" checksum="AF7953788FB3D939" modified="2014-09-03" version="1">MAQPTQDSSHLRKQDLSSLDVTKLTSLAPEVISRQATINIGTIGHVAHGKSTVVHALSGVHTVRFKHEKERNITIKLGYANAKIYKCTNPECPAPDCYKSYGSSKEDEPPCPRPGCGHKMELKRHVSFVDCPGHDILMATMLNGAAVMDAALLLVAGNESCPQPQTSEHLAAVEIMRLKNIIILQNKVELIKESQAIQRQEEIKRFVSGTAADNAPIIPISAVLNYNIDVICEYLVTQVAVPKRDFVLPPQMIVIRSFDVNKPGELVENLQGGVAGGSILHGVLKVGDQIECRPGIISKDSNGNIQCKPIISRIVSLFAEQNDLQFAVPGGLVGVGTAMDPTLTRADRLVGQVIGHVGKLPDCFIEIEMSYYLLRRLLGIKAPDGDRSTKVSKLKKGEFLMINIGSTSVGGRVSGIKPDMAKFELTGPVCTRVGDKVALSRRVDKHWRLIGWGQINKGKALTLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N4</accession>
    <name>A0A061D7N4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765916.1">
        <property type="nucleotide sequence ID" value="XM_012910462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7N4"/>
    <dbReference type="GeneID" id="24562271"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100590"/>
    <dbReference type="OMA" id="REIKHYI"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47430">
        <property type="entry name" value="GB|AAC33480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47430:SF4">
        <property type="entry name" value="GB|AAC33480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="476" mass="54924" checksum="B3AA7E24A90687D7" modified="2014-09-03" version="1">MVIRKKEVDGLRVGPFSKEEESTLRGAIENYVNEQFGGDKEAAMRNLVTQRGREPSDALLIGRSALPHRHPKSIYNFIRRRILQQKLGRWTTEEVYMLLDHYFKNENSQDDESKNKQRWRGVAHQIKRLPEQVHDKWKEIRPHIDVYRRIFEQDDLSKEERLDFIAQVCSGKSYPAQHLWKSANGESLSVSASKGAPSSISVQRSHLDEETRKRVHEYIVQLVEDGTIRPPVVYNIPWIKVRDKFTAFSESQIRLGWTLTTFPVAIKKHNPAFSKLVVARCGIYLMYKSRKIPDRLSHVDFADWFPQLPHLYVSMCVNSLLNKCISRFRRGTLRNADVRYANEAVVSGADLSALKNAKPPEIQCSIKAIENKEPSKWKESTAFFNDEGTRNLLSGHCRSAGSRWVEVKGGRLYLSLKRQIKLAYCETRADKHFESDMSILASISPCSLPTMSDDDPWWDYWQPDSPETTSSNSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R4</accession>
    <name>A0A061D7R4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768218.1">
        <property type="nucleotide sequence ID" value="XM_012912764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7R4"/>
    <dbReference type="GeneID" id="24564573"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211740"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="124" mass="13845" checksum="7238578F3340DC6E" modified="2014-09-03" version="1">MVVSKSTTGCICNYIKGIGCSTSKCECCRWCCDKCNTSGPRKCETCGKSTGTDDNTDGKKCTNLLKCRCKTCTPRSGIVIFFGIIMVLLVIGIIMYFLAWTSIPDFETFRNYWKNGMPSTHFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7V3</accession>
    <name>A0A061D7V3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0306650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768947.1">
        <property type="nucleotide sequence ID" value="XM_012913493.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7V3"/>
    <dbReference type="GeneID" id="24565302"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306650"/>
    <dbReference type="OMA" id="DITRMAT"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="3">
        <location>
            <begin position="2868"/>
            <end position="3463"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="2">
        <location>
            <begin position="3667"/>
            <end position="4040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2121"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2397"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4005"/>
            <end position="4036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2399"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2415"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4005"/>
            <end position="4014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4015"/>
            <end position="4026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="4100" mass="461741" checksum="21DFBEBF89B0884C" modified="2014-09-03" version="1">[encoded data, 4100 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Y9</accession>
    <name>A0A061D7Y9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">YEATS family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0305670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768849.1">
        <property type="nucleotide sequence ID" value="XM_012913395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Y9"/>
    <dbReference type="STRING" id="5866.A0A061D7Y9"/>
    <dbReference type="GeneID" id="24565204"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305670"/>
    <dbReference type="OMA" id="ENMTHYV"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16887">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="313" mass="35280" checksum="3092A092B2EB2965" modified="2014-09-03" version="1">MSTKSGKRVNVRVGKQIAIGTYAFPLTPVEKKRYGSMTHRWTCLLRSPTNENMTHYVKKVQFDLDPSFLNPRRVLTSMPYEVTEVGWGEFYIGVKIYFVDESLEPVQLQHLLVLNPSDNTGSNATTATNETFDEIIFNEPAAWFYKHLMCSTTDCLPPHKYQEHFWDYSMRDKETTCRYICCQSYFQNETYRLLAEASELSRQIQYLQEKANVIKNPTILTKTNPNSTFWGSKPTVIGTKNACSTPTTTPQDAPTKRDAVDSNSPESSILSSYDPKLASLSPSATVVSSTPSMAAEEKLQLDDKELGDSADGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z2</accession>
    <name>A0A061D7Z2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767230.1">
        <property type="nucleotide sequence ID" value="XM_012911776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z2"/>
    <dbReference type="STRING" id="5866.A0A061D7Z2"/>
    <dbReference type="GeneID" id="24563585"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202010"/>
    <dbReference type="OMA" id="REIHQQC"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="234" mass="27754" checksum="907981DBE4D05867" modified="2014-09-03" version="1">MSFLRLFRVYPSVSAVPRRGIDELWKGGYLDPHTPFSTKERLARAGHAWPSFLLRRKSFEDLRSLYFACLKEKNLLLGERWAAHQQGTRAPKHGRLKKVKLTMKRILGVITRREIHQQCLQAKDILRAQEEKEKYETRVFQLKELQKDLQHKIKRLGSADSVAKVGWSNALCGIEAELEELDLKLQPLRKETLQLRAPNWRYERKYSDLPGRITWNKDYVPALRRNMHRQFKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z3</accession>
    <name>A0A061D7Z3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0300270</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768308.1">
        <property type="nucleotide sequence ID" value="XM_012912854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z3"/>
    <dbReference type="STRING" id="5866.A0A061D7Z3"/>
    <dbReference type="GeneID" id="24564663"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300270"/>
    <dbReference type="OMA" id="PAYPAMC"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="14"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="213"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="369"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR96122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="520" mass="59757" checksum="7ED010928B696001" modified="2014-09-03" version="1">MTEPNANSSEDRYGITEPVSVDGPAEGDREATAELLKFLRAQNLYETEEGKLKREKVLEALNRLLQQFVRKNAARHLGIPDDEAAKISAKLLTFGSYRLGIVAPDSDIDCLCLCPQSVTRDAFFTDFYNLLKQVNLITKLHAVPDAYTPVIKLTYDGIDIDLLFASLPASTVPEEIDVLDDAVLRNMNEPTARSINGCRVAALMLALVPNKENFRTTLRYVKLWANRRGLYTTVMGYMGGVAWAILTARVCQLYPNFLPNQLIQKFFRVYAQWNWKFPVMLCKIKEVPNLPGYMAFKVWDPRNNPTDRQHLMPVITPAFPSMNSTHNITLTTKRILTEEFKRAHELLKSQRKASDMSRVWQQVLEKEDMFASHKHFLVIEVMAATEHIHGKWEGWIGSRMRFLIKKLEVVPSILVRPWPEFFKYKHHEWDYASCVFFGFKCNVSGKDTTTGTTEPTAKTFDMRMSIKGFKEIINGWTEMEAYKDQIAVNIRYLKNSQLPHFVNPRHKRTIDEVDRHAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D817</accession>
    <name>A0A061D817_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0305920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768874.1">
        <property type="nucleotide sequence ID" value="XM_012913420.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D817"/>
    <dbReference type="GeneID" id="24565229"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305920"/>
    <dbReference type="OMA" id="NIKSVFM"/>
    <dbReference type="OrthoDB" id="372022at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1245"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1299"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1324"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1400"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1596" mass="174358" checksum="7EF738194EB29CE3" modified="2014-09-03" version="1">MGTYNFGRVIDSYIATVFPPRHPVAPPAVAAASDQRADQDEEAKVPRRQLVLQCLQAAVIIAGLVALCMYSLHSRSSYYSKISLRSALKEPIAPNEAGVSKLLEGLASLSGGAQSQDGDAASIRSVLDVDLSAGTDVLRYSSISSRHDVALWLQFGLVPSLVAGLNSYNKLLGGTIRLTFLRTDYSDVEYAVAVDPAPPVAKPDPLQVSGVWRMGVAADEDDDDDDDADDSERGDSASDAEDAGGEEADVVKMDPPPSVGASEPPEAAVQGPDEEGGGDPDSVEGNEKSTPKVMLKLPYAPEGTYHTFSKSGGNFLYIPGTSLYAAMAALNMGCQYATRAPYFPLWAILSEPTTTSVTLEAFTSNAHDYTVGYVNVSFTFLTLPDGSANLVKVAKASSISSPRDGLTHGIQQGIFGFVVILAVIYVAHSIVIHRRYRVYTSKLLYGLDVVSKVALGACIIAYAARLYWFTGSAPYIQSVMGAGGDYENVVTQGRNGLVIDAIVLRAGFNNLRTHLLGGYVSMGVLQIASFGTICLLIVLCFAMMCSGGRVGTMMWLFVFHSIYHLGLGTACVLSALALMALVNMCILDHTAAGDGSFMHHFVTLAYILAGASGSRVDAYYRNHGALHTVSVIALLIVFWYCGVVTVLPIMLTLDADSEIRSFESTKPNGPYDESRYFRTKYALARLFRRFSTRSSAVFIRHLAFSRNNGCSGPGSPGQPSSAGFNGMQTRSGTMSSLGQNGGHAADHPKIAQASAEGVAGGYGNAPATQMQAAQNDVPEHVATVIPPDVEGQPVAANAPQRIVGARQRFRIWLFKFRSDHRNFRMLFYWVVVIAVMGFAVRDRQYRTVRRLLQQTLDDHLTTDVAQLPCALHAFVLQQPADEQLPDEASAKEPKGPSVDVPEDLRPSAFWGISGAPNSENQSVAGVEGADDSHVKPPGMNRGSPLHAFQLSGVGPSQDDGGMGAGADGGGAVQGSRDDGSASQESDAPGPKGTQPPPKESGGEPDGVKKVTVRVSQLPRRIATRKDVFQWLTAGGFGSLFTWLPFSNDMLNPMGESKQFLAIKNRFFAAPSQGAVYVELKLRSAAGFKCPMFSTMQHDAKYVTVRGLLHSTSVSIGARELFGSHSTDFPDVVERVQLELLLVDSYAQSKLYRATIWFDIRASGAVVPKVKVRSILGVHLDTAYNNWVFASVAISSLVMFVAFAWWFVVDCRKFFSGYDRRYGIANGNLLFWRKVFVFFVNDRLRFLDLLVIILIGAICGIYATIYFNSNSIYEHVPGLSTTEVRVIVNAAMRDVRVAHSSLWVLLGIIVCLILITQVQLVRDLFVILFVCLECALILYITVVVAMLMLILTFIFVIMTFANDYFNDMSKDEGVFVGSVRLLLGQAQLPSHVLDSSLFVTVMYPICLVTKTWIINMIFVYLWAIWPKEELDAKDKDLAHTEEMFRRDSVEGYQVSANSTNLTTVADDQLEMIPDDVKQFCAEEARRFNDMFKEFDERVEAAGSGKFEYVQQLHDRLGREMHEMLKSCEALQMQLEVARKRCEIMESHDDRNLEANISLLEIALADKQDELASVFAHYKSLMEESEADLDDRRPKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D840</accession>
    <name>A0A061D840_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0307350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769017.1">
        <property type="nucleotide sequence ID" value="XM_012913563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D840"/>
    <dbReference type="GeneID" id="24565372"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307350"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596075" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="819"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="946" mass="106286" checksum="185164CB97E92ED1" modified="2014-09-03" version="1">MRTLLVLGALLAHSIGCVIAFRCDFVKQDDLLTRNALAMCKMDVDDDSSLALLCPRRVNETEYVIHPQRTSDERANINTFVNRNGKFRSVPLSEVVRNEWSHKLAELESNMEQTTLKLTLPAQAVFAITERRLMFICGPKDLVLSEALQRHLYRLKDFDRMQALPWNSASLLVQEIAKIGKGLGVFFLYRGHIHLPLQGCGTRPSPLFSLDSEVTVDPITGVRSCVVDPMSQSPIGFVCEGRLEPADCMRSLIDHEGEVVAAPEPHSHLDFNNNKPWVVAKYFNGLALPPIDGQCRCVDSETGEVKARIEIRSKSEYVCDIADVVNRNRFGPMHGNWCSVVLHPGSTLTIRFPGGDVDSESGDDDFDEDVSTPPFSQLPPTYEHKNGFWPKDLTMLRQLSTPYGINVYDEIAYHKAVVGDALELDVSQMSRGEIKLKYNVGKPFALKGGLNSFFYHWTSISRNENVFERIRAIGNISFAFTHPYKMIGCDSGAERVFDSKRNVRYCLTKSMGNGIGDIHVCWLYIRIDDSHAGIRCAPDEELLPNNCEFSGYDLYSNTIMPFNRSVRSRVSHNIPGFQVFDFDPNDRSALSYACSCVDKLGYEKSRLILEYNLQDRYTYTLRREDASIPLLPTLILPWDEFRLAGEWSTSPISMTLNYKPERSIKLEVGTTLFLSCKLDEGLCDDEDNCKVRPAWLPTLPAFKYYAVKQTPGGPKLVVTRYKDVIAGTEGGFEVLPTVSKPTYYNLRITSNRGAIIISKDPVLKHQVPMTFICGKQLDRSDFGLLDTGIYSPSIPQSTATSQRYTWHAIEVNVETTDPYMQGCGVTYESDELFKPETPKRYDAHGKSNFGCKIDIHAAKEAAFYCPAPYVLDPPDCFNQVLVEGEVKNLSDISKTLLASRSSHFVTLHSFSALMETGETLCHTPLLECRCVTVKGVVLSTIQIENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D847</accession>
    <name>A0A061D847_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769027.1">
        <property type="nucleotide sequence ID" value="XM_012913573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D847"/>
    <dbReference type="GeneID" id="24565382"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307450"/>
    <dbReference type="OMA" id="NGCTEDI"/>
    <dbReference type="OrthoDB" id="361532at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10226" checksum="24993B70D1CC878E" modified="2014-09-03" version="1">MLTCFTRAWNRVKGLKVPTGGPAGLVYTCGVLNMIIFGSGLIILGITNNCLEDVLIGVAQLLLPIVGWLWSLVWGVLIIIGKYRKGPGDLTNEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D890</accession>
    <name>A0A061D890_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766131.1">
        <property type="nucleotide sequence ID" value="XM_012910677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D890"/>
    <dbReference type="GeneID" id="24562486"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102720"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="96" mass="10994" checksum="6E066A5D6FB76055" modified="2014-09-03" version="1">MAGVQHLLENGSGECDGKTKFCKNNCYQCTLFCSCACAPHIPGIVAFSIMLTVFIVLLLITWYSNWYQKPIENVRNYFREYRNTFNAEPLIKNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8A3</accession>
    <name>A0A061D8A3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766146.1">
        <property type="nucleotide sequence ID" value="XM_012910692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8A3"/>
    <dbReference type="GeneID" id="24562501"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102840"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="185" mass="21303" checksum="64F1CBD1EC3B2867" modified="2014-09-03" version="1">MRKANLGSEIEQNQGNLPSHVNHGNVRHAIHELQHAEVKVAHQNIAADIHEEPGVVVDENHHQHERRRQPPQGEENVAKAFQPRGPHEPLTWRQFRKLSVLHYVVRLELENVADKGTSEPEWSIRLVRFSVALCGRALVDRSRFACFQFCLSLCLLRILLLLAVIVKPKRRIGVSENLHRFTKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G3</accession>
    <name>A0A061D8G3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769182.1">
        <property type="nucleotide sequence ID" value="XM_012913728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565537"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308990"/>
    <dbReference type="OMA" id="AIYCMTD"/>
    <dbReference type="OrthoDB" id="365881at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1545"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1574"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1611"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1988"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2144"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1951"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1988"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2144"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2173"/>
            <end position="2185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2272" mass="254332" checksum="5C4CCDFF80560297" modified="2014-09-03" version="1">MASSFDYDDRDRRLRGVTPVFSCVAYFFVGISVTLVYALGYVCSIALLDGLGINAELSNAFYKTRQLIIFCAFIGASIALLFGLGGRISLAVEQCMLTVCYCGAAGYIWANSSDLHLRVNSLMRFAPATAMLSGMAQTAAIYCMTDYSMPGGVAYTYYRLTAFFVGTAMAGPLLSCWFVGNWLLGGDSKDVAMLFYISRSRMLLMFLCCLAAGMCAIAAAFTIYMFLCSGEKTCLDKECWFPLITCAPCHISRDSLKKQINSLYVPLLWTANPLFIAFVIAMTHNSSSSVELVFTQFIVYAVAAIAPAWLAYFENPPPQGAFFGHNAAMRRMLGVKYANRREVLKTTGADALLSVCRQGGRLSGVATYEESIGNSGMRAVSHLKNRKLNVARVSSNTQWTLLQGELWAQWQTRDATYLLCTQAVEKIYHTLYDLGNLYSGSLYDNVDEIMKQYCDFINCNGTLYGIPFSIDPSWDSIQLLHKMLLHQKTVLTLQLERTGTMYADGLTERVGVASCSFINRIPTLGECCVSILKPIVNTKKDKDEHHEHGKITIKHSANAGIRAISHCSCCFLSTQENIRKFLKSSIGSVKERCSSLSKDIYNQEMFKERGDAPEKLSLELEKRLMCMLRSFCESVLLLIDTLCLIDELLLLQEWLCRLCWDVKDLYRKLQQRPECSCEEHDHDSDSEHEHGEEHHSDHEHHDDDHEHHEGDNAGEESHDEEDHDDHGHGHGHGHGHGHHHGGGSGHREKTPKCVWKLLEKLVKMLCKVIVMMHSYKNELIRRIEEMSKCHAGSKHSEALYDDELSAVGLMNTTRVMVIVTRSISDLLQLNETMEKRGETTQSDKKSKADYCTGAYHLLLPSAEYLHDIMTRMLSPGETFLETVMDDVVFWYSGLTNTIGQLCPDIERKDKSSYSSLFHKDKEVEMKMPKDEILKEYGNTTKELLNACLKGSGDTARLLEERVKNYKESYGAVGADSMEKTKCLSSKSYAFTSQLNPCLKTVEPSKSDTCDSAEKIQNHAKSCIDHLGKLLSCTKEATVDCSKIDELCNQFDVIACGESPVASCSENCCKDGSESSRFAAVLTKLLECVSSLEKLKCDASTHSGAECSCCADEQGSLGAKDICNALYAILRYCFCCDNCTPGTYNTLSCGVLYIFHSVCTSSGKGLKCAKSPPCSVSGSMSHQTCLCSSSSPECQLCAKLKTVCSDSSDECCRNPVCWRERIRCYVLCGETCCNSHEMSKPLDCEGNCACSTNTCNDTCKLRGLFDSLFHCKTCLQNSQSSIQQVEDAPPAYKCNMKDCQCNITIAMKSGSNKKMGTTCCSHRLGCALRIITDDVTALKHNASQLKGGLEKLTQCAEKITESVKKVNESLTTLCKLLQFAHCGLQKRMAKVGKMYEVANKVRIGFPCYKTEINQIALAEKQVVDVLLKLLGFCLKVAHQHILFIQNITWTLATITMQCLRLNFLNKKITRIKEQINRVWLSLIGMKGSQKSALGVVTSSPGFSTLSTEDKLSVVYNARLKGERASQRFKPNLDNYSDATPFACLKYIWVLLCFWAVMGFFHWFGVQRSVANSKTLLTAITALSAMHLSSAVMSGTLHRGAGNGAGGKMGTRINLMVLLGIAVIFILSWISNITGTYRDTANSLNYVTEKLRVVGIYDNGQPPATQLIKSTVTKTFLSDLQSAFGIWGLSGPSRAGSIPLWYVLGPLSHTTAGANPHYTRSIPRKEVTFHDFLVNQSMRPIKSLEWVLNLMSFLQLFPDDAQMINVSAPFMRNLNPDAQLLWVGWETNTYLTDNFMNSMAFFHNVLHDLNLDLLDELHHLGKMEYKLKLISLWNTFYKGQSDTVPLQATKFNVERNMVTSKQRQLQQEEIAVRYINDWHKYHTWLANCSKYVYERKRYYEKRLAEEEVAAETDIVEEPKVTVSWLESVRRSFSSGESSTDVSQPTPKAPIATEDWDSDGDDSDCGNSDLDWVESPGCWKLRKRIAERFSGKKNKSERGDAISHNKNPAAPSRTGDGYHKRDERYPNLVEPADPLEWLLVNEPCTECVEHFKRQGSQVFSDGSEKAILVLSTGRLYEDIQDTGELLEEAAGWRRKKEAFCNNSSEFQEACLAAVRETYDRVVEFAEDDNEGNLVKLLHDTITEMKAAKGDSHTHDHSHGHDHGHDHSHSHGDGHGHGHSHHKKIKAPKPKAYLPSTLRDKNEVATLYREALLTAHHEQSGKSRSEASEKHRRAIVRATQTEDPTRDWWQLLTWMGQWSIFNGMPVSQRDVRYLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I0</accession>
    <name>A0A061D8I0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNF7-RELATED, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0301810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768463.1">
        <property type="nucleotide sequence ID" value="XM_012913009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I0"/>
    <dbReference type="STRING" id="5866.A0A061D8I0"/>
    <dbReference type="GeneID" id="24564818"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301810"/>
    <dbReference type="OMA" id="RAKQPAM"/>
    <dbReference type="OrthoDB" id="366288at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="225" mass="24927" checksum="12432735DF425D1B" modified="2014-09-03" version="1">MGGVISRCRRERASTNVTSQIVQLKGQRDVLEEHRASLAHRLAELEETTRNHVRTGERDKALMCLRKKALINDQLSKVDTYLYQVLQVISDTEMAQVNFDVYKHLKIGTELVAKISQDMKLNDIEELMELKQRCNDDMVEAGQILAQGLADVDESELLRELDTLCGAAASPAPEAVALTPTDVREATKEDAQSSSEPAHTLTTNLPEKLPDAPRAEPAQKVAIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8W0</accession>
    <name>A0A061D8W0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766366.1">
        <property type="nucleotide sequence ID" value="XM_012910912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8W0"/>
    <dbReference type="GeneID" id="24562721"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104890"/>
    <dbReference type="OMA" id="QYLNEWR"/>
    <dbReference type="OrthoDB" id="365521at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48650" checksum="D9A249842FAEF073" modified="2014-09-03" version="1">MVLHFYSGYSSSMEPTCGLQKVFTSDPTTRKIIIDNNINCYTQDVCYAQPELIDRLEITTVPVIVGVYRGRKVAEVNSDNVTSCGSELCRKLVEASSSTSPDSRISDEKELEERINALVSDKSCEEAHRALDEFANAHIQRLEVDDILRQLLARARLQLYHSNFNRSAGNGVRLSVDILRDQLKEIEQLISDLRKTHVEDLIASFPSDGRVNPQPYGGGKTNMAVGSHCSGIKVAYIMPHRDAQDTNNHCNDSGTMAEKRLEGFLAECSFSDIVNKSMFQDVTLAQLIKVELLKRISIVLFLDGNVDVAMEEAVRAYEELVKILKSDSIPVQVFESHEIGSVIECMLSALPWRHPAVLGARAALETMDGPRLLNRMRQSNRPLGGPVSKRRGFGGRYVWHGPDYRPKKYRPRDPEQYLNEWRYQADSNLPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z8</accession>
    <name>A0A061D8Z8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768633.1">
        <property type="nucleotide sequence ID" value="XM_012913179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564988"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303510"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2049"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2111" mass="237162" checksum="C4A6C1B545A9FFDA" modified="2014-09-03" version="1">MAPKKLTDCPENLREAIDWLIQVKNGGNGSGLDKLGNALKILIGEAIQKAKDSNKHTADKLRCAKNDTYDRPYCKELDERIAKANVELKISKSVQNFDKTSRDSLSADIKRFESQKADCVKSHYMDDQGMNDIQNKISQADEVISKLGNVSKELTNEDNTNILWRLCDGIEAFLGYAAGNYTGNGIVYGDCDRLRDAVLMFLNGVLVTVKDDENFRTYVLNGGDISKLVENKSGNGRTEFNLVISSVRSMLSLWDEMLTARTNKILYDIESFKDGIEHCYHNIDKQQGKGCMAMHASFMRSVEMLNRTISEIRCKNDGYAGVDKNLRSKLDVPFGYIDEGVNMLINSANNDGLIKAVEMIQNMFNTLPDELENFIRERVISTISDHSDHVEELKKYINMQIDNYRNRFVQERLSVVTRDLEMAVVTFSKNAYNQGGLKNVEVGNAINVIQQMLENVDNNVKDEVTLNAQNADTQIALIKKALNTKSQLGFTDALNGLSEAVGDPGEIFNEKHKNDLKAIVIKAQTDLKQAASRAEENAKNLGGLRNVKVAEAIQVIQQNLGRADRVTNMELLINLKKDIMDHQVRHIMDALNPDKPLPGVVKRLQSLNSIIEEPQQIFDRDHRNRLEELVAATEKEFLGALNQAQLYTTCTNFGLKKKVDEIFELVLKNVKSGKILISEIKSSITPALKKIGEGITENFQSGSNNISSKLRTLETSIANAIESNFERKLVTEITEHDFNGWFHSYMSHVLKEANEVISKADKAYQLVSEQLGMISSAVKHIKQKAESGTLNSVISGLEIQFAPIYLSIDTSSFYEDDRKSRRAYFDDLKSHLKNTLNILQVAYNNGYQSAAKTYLSEAISKIKAAVEEAERQYGDAVVSDISSIKSKLNKIVGDVFTKSDQREALQTLFDRDFDSLEDKVTSNSAFNDDYIARKQCFESLKALIKDAVENLSIIYKEAYQSSANTYLSRVIKAIEDKVKEAEGTYALAVHIELEKVKEKFKEITEENIKDKESKYEENQDRKKKHTLGTLFDKPFQDLQTAVLKHSAFKKDADCRKMCFEHLRALINNTVKTLIKAAKTHDTCALKAEEYLGKAFEDAKGKINTLGDSVKHKVKEACDRVIAEVCAMQAAHHKADLAALKSLVQKQRDNIFNIVNEDLKTGIKGFLQILKRWFDIKSDQLTTVQDLNRLSGEFKDLYDNLYSYVKFQHDGLEVEVDSEEDASQPQTQVPPLQAVPTPMASGGYKARPAMAAVTSQTHGKSQGKPELQNSGRAGYLRPVKRADKSVSKDTIATYLVGLEYHSRKLYNALTVGNFTHQSANICHDFAKFLESMRPLMFGRQDNPLLDIIKSGLKSFLAELGKAYISTYCGAAHMYDWNLNGRNCAKVFMTLLEILKTDFDELHEKCGENGVWNNKTICVLAGSNSYNDLGLCLKRFGYGVPSKDGKQDNELQCKSNMNGNEIFTKLVQQTVTVKDDYTLMTTIENLSKCLATYYRVRHYSTLQSKTYPLSVYQMLNWLSGFPNNPAYDELTLNGFSALFDKPDEEAADDTNEGVIAVAGDAAENSMHDLPFKFADDDVLEAYPENITPTTLRDTLAAVCANSHNVLTSILGHGHSNGIYACEFNTNSLSLWYPADTNSLVCMLFDILKRIHHQLYILYHQCSYETDLGGWRDCWYGRDVGGSDWRCNRLQCAGQMGDQKHNQTCDQKCNQSAGCGLKSPLQSYLEDGLQGYLPHQIKYEKGKVDCALKDHSGGPCKSPIGFPDISVTASHRYIGKHIHVALASLFGEKSSPLSQLCAQLNCLLPSAPKTLDDMFGFYLNFIGGWSRKQKTAFEQTVRDANFKRTNATLDICPVFESIEHKPAKPPGQKNSHITGDLYSLVKCRYNESSTVAHPCGPYLRPSCYYASGIFADKHNDKYLSWIVYLTETFHRLLKQLYEECNGNCGGERPKCRISKCVEKCAATTSPLSPESTHKASCKSIVHCKYTRPTFYKFGFIFRDCKILSDQSSRRTCQDFCTALNHVINDKETVGAALAKLIYVTIPEYLLEIRKPFMLLTLTLWLLSLLYLLHIMVIRLDLLHIKSHLRSPSSHRIAAQSLLAAARVGKLAQITYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D939</accession>
    <name>A0A061D939_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0205720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767600.1">
        <property type="nucleotide sequence ID" value="XM_012912146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D939"/>
    <dbReference type="STRING" id="5866.A0A061D939"/>
    <dbReference type="GeneID" id="24563955"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205720"/>
    <dbReference type="OMA" id="CYAISVV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000004">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="5">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="151" mass="17427" checksum="79C813708F90CA1B" modified="2014-09-03" version="1">MARKGKCKMQRFILALDMFESDHLDKEDEEDEYEDLNGGKFDFVPRRTHRQRQEGESTIFKLRACISCRLIMSEDQFFERGCGNCAFLQMDGDRRRTLDCTSSNFSGLISIMDPQKSWAARFNNLGDVIPGCYAISVVGELPETIHDDVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9B9</accession>
    <name>A0A061D9B9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="2">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0310460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769329.1">
        <property type="nucleotide sequence ID" value="XM_012913875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9B9"/>
    <dbReference type="STRING" id="5866.A0A061D9B9"/>
    <dbReference type="GeneID" id="24565684"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310460"/>
    <dbReference type="OMA" id="KPVRGIC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="341" mass="38766" checksum="685C5AAF1B148193" modified="2014-09-03" version="1">MKCASCLVEHPALRRSVNRLPYCKKCFVEAFEDEVYQVIQEQKLIEDGDVVCIGVSGGKDSSVLAHVLATLKERYKRNWTLVLLAADEGIRGYRDDSLNVVMNMKNPNYKELMILNFKDRFGFTMDEIVSLIGQKNNCTVCGTFRRQILEIGARLLGANKLCTGHNLDDNAETTLLNFCRNDLFKLAKSLNERSNASIAARQPDEHNAETRPHEDSKTESSNGTAFTRIKPMMYCYEKEIVMYARYLGLEYFSTECSYAPEAYRGYMRTFIKQLEAVDPRIIQNIAHSSQHLYAHYPTNRELKSCKKCGIEGLNDLCKACVTVEKLSSLAKKSQSNSNIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9E2</accession>
    <name>A0A061D9E2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0310710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769354.1">
        <property type="nucleotide sequence ID" value="XM_012913900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9E2"/>
    <dbReference type="STRING" id="5866.A0A061D9E2"/>
    <dbReference type="GeneID" id="24565709"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310710"/>
    <dbReference type="OMA" id="ILEHDEW"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="173"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="590" mass="67501" checksum="4CC690693DCE007E" modified="2014-09-03" version="1">MASGTQTYNFKGITTIPTATALLDTVLSETQRRTPTEVHKQFKISRIRKFYMRKVKYVQQAFRDRLQRILSQLPQLDDIHPFYSDLFNVLYDRDHYKLALGHCNAARRHLDKIAKEHVGLIKFAISAYRCKSLKVAGLGRMAKVIRKLAGSLKYLEDVRQHMSRLPSINPYTRTLLLTGYPNVGKSSFMNKVSKANVDVQPYSFTTKSLYVGHFDHDYLRWQVIDTPGLLDHPLDERNTIEMTAITALAHIYCAVLFFIDVSESCGYSIEQQVALFESIRPLFKDKPTLVVLNKIDLGPFDMNRMVSLEGLRWVKVSALTGENVDDAKIAACRLLLESRLEKKLSQAPQSAVLKLAYVTNVTPNPARPPTERPEHAGSGEVETEKQLEAMGGGPGVYSVDQRKHHILADDDWKYDEVPEIYRGRNVVDYAYPGNEETLRRLEKEEELLLRQLADDTIDDEWEDLAEREAEMHSRIRQVKFENSLKRKKGGPVLNETIKVKKMRSKGKDRIKLHQRASRLAPMPIDTIEGKLEEAKSRQRQGQGESVSFSRPKARVKVPKGTFSEHDRTIAVKRPKHMFTGKRTLGKTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9G8</accession>
    <name>A0A061D9G8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallothionein like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768823.1">
        <property type="nucleotide sequence ID" value="XM_012913369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9G8"/>
    <dbReference type="GeneID" id="24565178"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305400"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="214" mass="24023" checksum="4A49A7DFAEBA4AF3" modified="2014-09-03" version="1">MTEKQVEGNKCKCLNITCDENINGPCSKDACKTCKSCCSPGCKGCIKNCSTNEPCPCDGYVIGRCPDGIKCQGHVKYDNGKPVWDRKEYENNCRKLHGVNCTYNCDRWAIGVRDMNKNCVIICTYCNKLCSQDWCRIWLGVLIIGLIILSCFIVMWGMFPETFHRMTTGIRAAFPISPVSSCRSPSHLVGDRIPDEVNIDRYPAFSRRTYAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I1</accession>
    <name>A0A061D9I1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768833.1">
        <property type="nucleotide sequence ID" value="XM_012913379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9I1"/>
    <dbReference type="GeneID" id="24565188"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305500"/>
    <dbReference type="OMA" id="TYPCIVI"/>
    <dbReference type="OrthoDB" id="360455at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="993" mass="113995" checksum="6ED86599BF8D5CD8" modified="2014-09-03" version="1">MVVNSAARPCSTLPTTSRLLLIILLCTCFVNEVALLGVGALSISTANGATLTSGNALGGHHGFAGGEGVGASRRLQNARFGYRALPAYAAPTVPVSVSKVRCGEIVVGVPERRNEDGTVEVDIGAEAPLVVARESLVFLSDEERSRFDKILESFGQPEFVPQKSVDELVGDTLIRARQMPVRKRMTHMRPRLIYPDDCKKDTTATQILSYDLGVGGEIRPRQLSTPRIAGRKQPHCWFRDDQMEFIVTDVDVYGNKLLGEVWSPSIVETKRQAYMAMAVESVKPTCPISPYMAVIKERDGDLLVLQLLDEHLEGFNAYSMALPKDNPGDRVMVYLAAADPDLQHVYFTRNGIGNEQLREENLKVLYDEMLHHYVKTGRWFRAQYEEDHGESIQLRVAGKPIPESNYAAHIFLSQMPYFSPEGLLNETFKRLNMPNEHFYYHDTMINVGKLNYGFNYDNCMFVRVHEYKVPQTLYSDGKVKVSRSVQSIELTTLNVCKPQGQLEKAFKKLTEQKVEEMKDLKMYTSYPSLVLGQDDGYLYLAINYLRKPDFTLADDYFVGIMKLVPKSKTAAPGSFVNARVAAISQNQVNMRYMQTRSEIGGHDSFKYTAFTHWLNEVNEGKQSFGFSRFEQQKRLNLIWMDGLCIPPPGSPQYDKYLALQPAITETAFVHAIDESLSPMGTENVLDQTINGRQRPLAPASLTTSLLRVARQYREETEKRRHVPIDMANFGSYTIEFDDHPDYAIAPPRYYLHNREIRMALIEELLNGRELWKFKRTLDMARLRTEGEIKAFFYDSRGRSFYSLLERMRDPLERRQVKPKEPLYFERSIKLLLSGIQDFYLEAIYDATDREKLIFASLVPRSGKIGDFVQMDELEQYDRYVRNDFVMDKEAREALQRVLRILSHPNNSLMSHMRHRHRTIPDDLFYAYRKTLHYETWVDYKMPEEELREEYFSSKGKPLLPAVSELVKEPDKFPMHLEKRGMTQIKGLYTQLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9R3</accession>
    <name>A0A061D9R3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ELONGATION FACTOR TS, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0313330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769617.1">
        <property type="nucleotide sequence ID" value="XM_012914163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9R3"/>
    <dbReference type="STRING" id="5866.A0A061D9R3"/>
    <dbReference type="GeneID" id="24565972"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313330"/>
    <dbReference type="OMA" id="VIVELCC"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="4">
        <location>
            <begin position="152"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="400" mass="43804" checksum="27BA2DE2F25DE3BC" modified="2014-09-03" version="1">MWFKCRLTAIVLLSQVNEDVRMACNVIAGLMKRPSLHLISVLSSWNARLNLNGGVGCNSIAAFRGMQNLAAIKQLRKVTNAGVVECKEALSRCNGDLDAAIAYVRRAQHNRQLEIDTERPVFGMFNFLVPSISLHVGKIAIPSDIRTREKSVIVELCCNCDFVTSSDKFAQLAHDIRRTIQRSIDNSRINVTHSNATKAAAPLDIGSCNDIISDGDDGLTVSQMLQRSSAEFKTKIVMPTVIAFQRNLRNDHVGIYVHQKTSTGEGVMGSILGLVSLRHHGVNATLSNHLSDTLGDIARHLAIQMVCNPLNTEQWQTEEGRPYRMADVNHILQQPWMHLDSVQSKMHDIATKVGLGKCDIDSEASVGRTLDEIAKLIGAASITVPGALYMKSGATPVICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9W2</accession>
    <name>A0A061D9W2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767890.1">
        <property type="nucleotide sequence ID" value="XM_012912436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9W2"/>
    <dbReference type="GeneID" id="24564245"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208580"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="79" mass="9009" checksum="FE5C628830BB934C" modified="2014-09-03" version="1">MKDVDGAVKTAKNKATEVCEKLNVSHTVSNNFVEIVKAIDKFNEVHRELIDVEDTMKCVFGVYDNTTKIFHNDIYISMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA03</accession>
    <name>A0A061DA03_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0108730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766761.1">
        <property type="nucleotide sequence ID" value="XM_012911307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA03"/>
    <dbReference type="STRING" id="5866.A0A061DA03"/>
    <dbReference type="GeneID" id="24563116"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108730"/>
    <dbReference type="OMA" id="GHVVETN"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14832">
        <property type="entry name" value="AP4_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="146" mass="17037" checksum="2F86473AD8682EC8" modified="2014-09-03" version="1">MIEFVLMINRQGQTRLSRYYKDLSVAEKCALEGEIIRKCICRDETQSSFMQIRQHKIVYRRYASLYIVIGATESENELALLELIHHLVETMDSYFESVCELDIMFNLEKAHYILNEMIANGRILDANRSHILQPMHLLDKAPQSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA48</accession>
    <name>A0A061DA48_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cullin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0307210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769003.1">
        <property type="nucleotide sequence ID" value="XM_012913549.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DA48"/>
    <dbReference type="GeneID" id="24565358"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307210"/>
    <dbReference type="OMA" id="DEWEYKY"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="9">
        <location>
            <begin position="386"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="8">
        <location>
            <begin position="1818"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="domain" description="Cullin N-terminal" evidence="7">
        <location>
            <begin position="1938"/>
            <end position="2382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2248"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2248"/>
            <end position="2263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2615" mass="295046" checksum="DFD66770F3FFD8FE" modified="2014-09-03" version="1">MLGAHRHVFHRITAEIDHALPAYVQAVRDEEYDDLHGCVRSSWENADWSDITYRFERFAYYCFDHGYLGDVSNIDTLAMWARRMWMLAAHDIDGVDASLWQALGSQEVLDELSHIVKSQKRLTMKFRIRLLRCVSYVLHSIVHVLPSIWEVDNHNCRDEMERRFNFITIDVLLKLFEYYIAEQPVCTSSTVRKFWISAVVRIAGCMRRLWVYRDDVGIDLVYKVIGDVDNLDLRSKEIFFKFRLILLMCPSVTLYRFLMDGTLFKWWNLVPEGTVNSWNSMMLLLIVRAIKFAWAAGKPYLTDDITTNLPSIFHIFSSSLSIPNSGNANRSRESIPGEYTVLLLHPLYSSKLFGQLLAYLVCSINEQGVPVVPFATEIMDYLSSAVSVMYPYTHPSNGGKWSSNIANFVKHFVLTYTVRVGRERGSPQITASTVGTVNGDTRYRLTRANDVAVVDLFYSMARQGIYCKNLTLAPYYEDAIKRLCTLLPDRTLSELVDHLIMSTETLTEPHRILSCMRIFGQLMPTILAYTPIALLPILDACVKGIDAADLFKTGQALTLVNIIFSHMPCRDLSDIELTHQAKVDLIRSVYMRVSAETSGDVDMTGQGTPVQCTAVDLHNSVFDVASPLVAPNSEDNFFSREFVVLRTTKNMDEAVAALDHVLSQRKCISQNLPGWCQDWFEAVLRLSENSSRPDADRESMMNAVEMGTFVLLRSALATILSQTDAHTFGCICETFVRWVCDNAFRENALKYMVAIATAISHSNSKMAMEMVFDKLFERFSREVENSYAVLSEDQLAWYIGCFSGLVRRANVELLPRLPKLRYILKAGLSHASKKVFKGASKLLQRCVESLVGVYFTDVKCANNFKDDLCRGLLLWDVPWFARDAEFVNGRCDITGTLGVKWHIATAQEMDCAVDLCWCFVDLMMRLTEGTVDMAVPTKPIGAVPLEMDIDPSCTLYVRMNRACMLAKRLLRSLSQFSVDDRPVRAKGLLTVTPIDRPEITEVQQFVLQFILTVLSKFGGIESTNDLVVANIYTKLLKTAGEYMCRCVQQNDSNSFENVSVVASMKNECYIGTTVTAARAMLSWTSSYHGFHKEGHWQDAPRVAWLLMVYERFHYRLNLRKLDHECVGPRKELLNMILQCATSQFKDLAHHGRNMIKPLINLHRRVRSHVAHFVLNQGIAVYPTSADGSDRAIKTLTNISDSLILSLLKHIGSSDIAFDKFCRFICPAVMTVPNKDSLMVKFDNRLVDVLKNREVMPPTETTAGTMNFILDSLLDSNSKQVAAASHWRFQLYATSLLVCFNDLIPVDSRGRYIAWLMEAVDRTVKQPCVVTVALHGIYRLLGDPANRGSLPAELFEYKFAETLMRAICVANHEDLTDDNTATLVRVNKIVTSVIKLDRTWPRNRMAANSGSFSLHNFYLMYWYFSAMLDAGKVDTIEQCKEVLAGLASCPPIMRDDHCAFAEITAALMKASLRAERSVRERIWEVLHPVIKIDLETIVQDRIVDFMDGLRLALEDYDIYGDACIPIINVGINFRAPLKMDALQACDLASDNTTSPRIVKQLKLYRALLQQLTTKHRGIFEILCDAILKEDVICNSPLQIVEEVGYLCSFMAGLCRMYGELHEFKQSVHSHISQLVARVDANGSAEGTDDMPIKGLLSVISMLYSASVPVQDLSHPYTGQFLSFCLKHRNHSNTVVGDFATRAVSQIALSPFHHQKDLSTVDAVVSILDNVCKAQSYNTKEYAINVAKKLQRNMCMYLRRTNAVKVLLEMYISALQHRQARDAARDALTYIVLSSGDHLYIELTERFYSLIKENHDETASAGVFGLAALIGTAPYHVPKWMPYTLTRLASCGASRFPDIVRRVVQTTLQDFFKSHMDAWYQVHVHKFTPEQLDVLEMYKGCPACAIFTASNCVDRIADHVDSMDIRRPPKPIFTPNDFLAGYSIVYRLCTAKNSRNEEPLYRRVSQLFVDFINRKVALIVAEKDVSQIPVSAEAPATVEQIVDTWARFRVYAEAVGRLFSYLDRFYVNYSSSSPVKLIALEAFQRIVFEKHKERLKRRLLELLDTRRSETDVDEFEVGALAQMFHELDGSGGLQYKNELESEIIARAARYYSTMGPLWVQDCDLLDYLSIVDHCLEQERADCARWLSETTLRPLTDTVLKALIQDRQSDIIQKVGEIDSLIDQGSEADLQLMYRIITPIQGGVPAIAESLNRSIRRSLSSTVSFDEVLSGWLRKRAELLKSCFVKNDTPTASGSGENAASSATTADQENASSSPADPAVDPAISNAVRRAFGNVIAQLTDFTKDLVDHWDSTLVSADPGSVTRLRNCCGLLEALHHRDDFYQCYKFKLAGRLLYCRSSLNMERTSIHMLQGLGASDEVERLRRMIDESSEARKCGTPFMVISKFNWPCLRDYSEDVKLHSTFEDGFSKLKEMQRAHLHRTISHNRMLGRVELELECGGATRTLICDLVQASALMLFEGPSLALDDIAAKLGVNRSFALQILQPLFDKGVLSLQAGDEVELNSAFNDGCDVTLDAVPSYRDLRSNSASAETSAGSALDPDAAIDASIVALLKAMKSMKRDELLLQLPRFSRENVLARLQSLRERDYITISDDTIAYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA63</accession>
    <name>A0A061DA63_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769028.1">
        <property type="nucleotide sequence ID" value="XM_012913574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA63"/>
    <dbReference type="GeneID" id="24565383"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307460"/>
    <dbReference type="OrthoDB" id="364157at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="41494" checksum="A85D12371AEB53F7" modified="2014-09-03" version="1">MAATAIWKSFHLEEEYRRLMGDRAAALECYPSGEGRRVIAATNVFASDPYALPHGTDARVRELYPSLVELSRESCYVSEVGLEKMAAELRSSGTYAASMAAPRSLPPIEPFMMSSPAVTRRMRPEPRLSTRPEPQSVVRPAYLRSDTGRMPGTRANDVLNESVDRFATNAAATLVGNCNIFDTDSYRRGALGSSIPLNEQSLLTPVRAPRSQFNFQKEFLSAFQPGVESGNDYGALETPVVDRAASNNATVNVDTLVSPFPWEKSANLARAQEFGYTPRGRAGEASEQKYPSYLSGDLNRANGSVVRPLRRVEDPVSLFDSTRPRRISSTVAPGGRDSSATGFNVRSPLRSLMRESDHSYGYKNSHTTPRSLYHNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAC3</accession>
    <name>A0A061DAC3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0314000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769684.1">
        <property type="nucleotide sequence ID" value="XM_012914230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566039"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0314000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0314000"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1735"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1797" mass="200343" checksum="993306F73097FDFE" modified="2014-09-03" version="1">MAFLHRVLGAVKDDEAVKKYNEYMPVNNKLEKVLEEVNKNIGSGRAGLAASVGAVREWLEGYEGEVKEKNGMVVGPLKILDKDISVVLNAIKRKNASPYSDEVLKSWMEEVKKLPQKSAESLEKLSKIDKNLRTQIEPNVKVIDQAVKDLARSAELDHKGLEKVAKDTDAEIRALESVVKQVATREEKKCIGELQENFGMNIIAPMEQVKNQLETINENLERWIREVAKVVEAAIKKCDEILQRVDKKTGGGDAEILEKTRLLKYKSLTLLAAATLAKEKVQNLVPHALEQVKQMDDALKNDLYKVKDAVQEKVTGIKEAIGKLYKVVDITNSLSDSERKKKIATVLGYIYGQLNEIKGHVGESKKRGENKPNDKSIYYNWCEVKDKIEDYVAKIKGVPGEGLLHNKDGLKQIVDGIKDYATGFKSLLEGSIVATVTAVVDSDVMQKGYLLWYARDNKQNFQGPSSIQHAARGVTQEDLLKKITPLVKKTITEEMKSYVDTVRITDYDDPEHMLTAISRCLTTCSAKVEGQENKIVSLIETAMMSNDELRLTMSTTYPNKYQPYNLNCAVKTIVYAVSHLAKDADTELKSFISASHIINLKTAIVNADNINAQFRSGGTSYGSKIDTSLKEVHTQIETLHHQLQTATQAGSDGDASNTAAADVDTAIEWVTNTLDAEIGTTTDKTVQLPDRADKFGGYKNFVNQDSTKLTGDAGKLEGALPQKIKDIGDEIKKALNIIAPSPSVGEQIKQQTFDEPFTKIAEELREITALVKKSNSFMGDDKADKGVLALLRDLGMGLNRGLAGVFSNGLKDIEKHLENIIGHEDDTTEMPTTVYGIINACRKFYELMRTKINTCISTITDSLATHVKLRIAAIRNSALSQFAQSKAAALQKLQELVERENAAIKKIIEEDLESGLKGMMGKMKDNQTFLDTLQTQTELRTATPQVRMFVDVLLQYVESEVQTSTGQTKKDTVASTKIADVKAMLGLLLDDLSSSNHFDHTFSRNLADFTNTLSALQPSTFAGHNHPELPDAMRGGLRKLVGELGRAYVSRYDGSPAITDWLLKDPKQQSAQKVQDSDQNMILTTNGNNCAKVFLTCVTSYVDELHHLFYHGGKTWKEHFVAGTDTGNQNTNMLRDYLTIHGYGIESLKKTYTGKEVAFRLSRGFTRHKTFNKDPSELNSVGECFEYFKEKGGILAQLFTHLHHYYEVCHYGTMFATKQPSSVYQMLLWLSGFPYNPVYQPLSFNGFSELFEKEENNAANSEGDDILLETDDADTLPAHPENITVGGISGMLTEVCHQAHDVLTSILGHGHADGIYAVDFNTNSQGFSYPSRYGQCIDMLVDILNRLYQQLYFVCCQCCNDESCSGWRGCLYGNAIGGSDWKCNSKQCADQKCNQKVNQTCELHPKCGVKSPLQSYLEDGLPGFLPHSFKKPGCKLECTVSNHRGIPCKTPMGFTDISTMASHTQIGEHLRKVLAEFCGKQGSPLTKLCGYFNCLLQTPPQTLGDMFAFYYNFTNRWSMGNSEHREAAFNTAVNNANFGVNYEELKVYYIFSFSHSEAWTGHSAGSLGSLVCTSNDAVVCGPYLRPINKSIYGMFSSKHADKYLSWIVYLTATFYDLLKKLYDECNSKCGFKGSNCHEKACIKECTTTSTTYKPPRYHDPKCKSIVKCNSTLPTLAKYGFVLGDPERLNRDGQSHTKRTCRDFCDVFAEAFDKDSHLVQFFKAIDNFMFTIRAPFLWMTVALWSLSFFYLICVMVGRLDVLHIRSHLRIPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAE6</accession>
    <name>A0A061DAE6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769709.1">
        <property type="nucleotide sequence ID" value="XM_012914255.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAE6"/>
    <dbReference type="GeneID" id="24566064"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400150"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2072"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2147" mass="232457" checksum="01571A118E8ABB65" modified="2014-09-03" version="1">MAGGISVATLKECFMLLAELNRREGIRLQGQVAHQMATRVATLYNSHGFEWQLQLPLNTFLRKVSELRIKLCKQLPRPKVVISGQNLSIFVDSLIECIPQFLAAMYYLLYRVDAKYVSVGGGSWANLYAGYYSYGHDELNTYLYTRASGNKYGVIPGGFNFGDIESWDYKAKEWNEGKNLVKHIKGILDSKGNIHFRNVLFLSFNGRSEAVYTGNALGVIYVFCQVVVNDSKGEVKKGLEDHVKRLNPARCLDWPNVKVVCSNLKSIYDGLITKGPFNTIGEPADIAHLNHTTFAETFANWYANESASFLGCVKSMHSWVTTGSYSSQSFVEKFLFPRGFVFREDKLKQASNALNQHTWVETLVNLVDKENGLLKLKELLEGCNCVQKAANNPDVTSNQDKKAAGLSPHDTHSESGSPPASVAQFISPSPPGEKRQTVAQGSTGQLGPELKVENGLSGRTGQLTPVSSKSRVSEQQPFVQTSPVLQPVSPPSAPRASVVESKPSARDVSVTVNAPQVLEPIATQDLAFTKFQIQSGPASQSSGSSSPNSGQGDFKHSQQSGRSSTTKPDSFTNTTAPSQGAVVGSSGEAGDTDVKSQDGLNSTQPPAQSHTPSDPNAVSAAPLDDSSQVVPTLSLRSSSQEDSHGHAAGTSDNSSATVSGNQSSDLFNTADAAATEAQQSVENQDNGSVHQPGPTPPVHASQPPASSTSPPGPTGPGSMAGDRITGLPPVFSEGHDSAASAPNVLHQPPSASGTGLPSSGPPGLGSGSNLRGPGYRSESIQRNDQRKSTDRVSDTEGHATQVPGLSGDVGIGGGGGQQEGQDSVTHEQELGSSASAKLQTRQVESLGSERSHSAAEAGNLRHNDSGLPPNSGIVTTQTHVPNQDTVPPTSSVVEPGQESGGGSGGNGLDDSHDNLPSHQQLVTFSTSAFPSSVDVKIQDPPPSVLHPSDGSEGTGDHTSSSTTERNSRVVQLSRISQTPVNPATMTSEDDEINGGGGDLSMVQAADAMNQVSTGQDHDALQAPGRQIPDVSTSESSQSSTTNSSKGVTQFSRTLHTTVNLDSLGSDTEQDEDTGGGDDDSDDGDAGTDLHGSQSEDVSVPRGVGNTGSPMSKYTVTPKPGDPIQGPQDNIQSGSFIGSADPQAVSIQHPNPQSSSTLTSSRSPDVVYPAPPVSDPPTTPTSKHVPASPVSDVGANIDDNQGTVGGWNNQGLRANAGSFGMPSTGVSRGTVGGSSSSGAGAGYLIRSSQQAGVSDLSPSNTSANLGSYASPQLQPKLANPARTIFTFKETTDDQIWDEIKKETLPMYLLTDSTTPHTHHASIARSHSGHHRPETSRRPNGGRTVTGRQNYGTQANNGRWYSSHLSHNDFMNLRFDIDGAEVEDDSDIRMQAKVDRILTDNAVYKDLLRLIAHQNNEDKERRQKEAEENYKKDLQRFEERRDKSILDSVEEALVPIERKKNPLYYDVPQIQLTVRTPETVFPIIDLMSFDQNPIEDSFGVYNMYTNEINLSSIPTVHIGHPIRKDLVLEPQDLQPPRSPAADLIIDVPKRTLPESVPDLDLRVDSLPRQSASPHQPFPLFNPALTVDIEVSEISQHALLPTDSDTDVYKTPALDFCVPMWTSQTPNDNLEETPEIELFTAEPPCTVRDMLRWLAGIRRPKHLEVLEKCINRALGKVPDVIPGNPTLCVSNTKLKSEDVIKALKLASIFSSSVLSAIEPDWKQKSSRSGTVKRMHTDHDQDPDGCALLCCLQDYVYACYHQLAFLRSQCAGDKFRGGWMGCQFGRDVTADSPLQAFLTDAYYSRFKTHFFDPCDVCLKSRIRMGFRKGDFSKSPKDASYFYYLLSPSCSGDDDPLMTLSSYLNCLTRRTPRTTGEVVSFFQHFGSELHKDGIGILSDMGTALSTPYPNCAEWDHLGRHDLDAVRGIRVSESPISKHDNDHAGTLSTLVGCDTTNVQCTKLLSPITHRAYAMYSPCFVHTYLSWAVYLADTLRESLDRLRYDFTRHNVSKCGSIHHCHDALPYLYFHGFTPPEGTPSSSLTCSQVITKLKEVVNGGPIAKLINCMDDFLYRVRWPFIYTVITLWSTAFLLFAHTALYRLDVLRIQSHFMRSRGSHVIDVKALLTDGTKMPSLYDIDYFDDEALAHAWNRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK4</accession>
    <name>A0A061DAK4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0309150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769198.1">
        <property type="nucleotide sequence ID" value="XM_012913744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565553"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309150"/>
    <dbReference type="OMA" id="YQRDMRC"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2988"/>
            <end position="3010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="688"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="877"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3062" mass="340654" checksum="52F278D1FD935025" modified="2014-09-03" version="1">MAPKALTECPENLREAIDWLVQVRHCSGVSTLSGALSALFDNAAQDAEKSLPSLLDTDRPSARDVVSKLRAFQSTLPKDSENPNKNIIHNLCASACSFLGYRYRGTYDGSGIVYGNASRLCDAILALLYAVFSDVCDNQPYVAGRSVLHDVIVQLKSQLWRGHKGFCQAIPKVATGLQRYNAAVEASNERVKEPIQTVLEYVKPDGELCRGINILQITETSTSAEDEKAVESAVSLVEGCKEVARVLSKSLMAAKDAINDLNPKLKKKLENARRSFFNHVDWLSRWSKKGQKKMLDKMIQKIKNRLKQLANAVKDKIKQEVHTVVELLKDRVREVKMKLEGITVSLEEYVKELGQWMDEAKEYIQDVKKYVNKIMQELDGENRKAIDKAAADIDSELSEKVEELNQWIETADAAVNVAKDKADDVFKRLDKDEKSGTKISQGFEKISEAKENVSEVSTQLLSVHDDLVGWKDATQGVISKAAGKAGEVSGQLDPSQKGDGNPIGKNLKDIETAEKTISSANEQLKSQVDKLSKWITEADKIREQAQKKAQEVYNSLDVHKDLSEKLGQIKTANQEIKSVNKELSEVDKNLEEWKQVAGKVIQDVVKKAEDVYKKLDHGDKQQLISQGITQINAAKDNVDGVAKGLTSVNEDLQKWREAAKAVLGTVIDKASEVHKQLNPDAHDASHPIGQKIKEIGDAKQEIDKANQTLGQQVKLLNTWINEAESIRAAAESKAKEAYDKLSVHEELSKNVNRIMDASKAIKGVNNAVEKKLKELGTWNEKAKEVLDGAIIKAQEVHGKLQDAVVEKIDEIEQHNKEIITANNSLEKEVGHLGKWRAAAGKVIDQADEKCDKILEKVQNEHPKNYDKGNKTVIFQQAEDLKNQGKRLLDAAKNAKQRVEKNVKSALEAVNEMDSDLKKDLFDVKTKIKQGITEVISTLQVNKLGERVREDLVKLRERIGNLKGKVNKNEKNGGTLVKKELDALDQAKNTLTEESRKIKEQKLKEMDQRFNSAIKESLNQEVEKVTTAIQTLYGKINPKNDSASETDKKQLHKIFEHINNEVEKIKGKAGSSASDPIAKGLDGIVSKTKGLVRGFGDRNKSGHGFSQRVDGWIGNILGINQNTGGKQIKGMEAVISWIKEYDSRVNERNNALKDQFKQKIKEALNEQITAGQDKISLRDVKESIVENLTKVKEACDTFADALDAKLTKVEIEKTIAPIVRNIQGSSGGAGTSGGNAEHLTTAVKTALIALCRCVKQVASEIDFLGVRMFGGIIDETKKTVDGLNTNLTNAAKTGTPAIGTAQAVDNAIDKVREEVKGLEQKFEQVKKPVEEAVRDLDTAVDTFDKQAQQQVKDAAEGAIKAAAKEISNSDNVDLDEALSKMQNFHEAHQKINDELPTQLESLLNEHIGRDGKVGGGDTVSLKHTLSLGAYRKHIKQNGGDEGKLKQAIERIRDGVDDALKMADPSVKKTIEELTFNSAFALIASELLGITHLVNGTNSFVDGGEQGVKALLTELHKGIGKNKLADTEKGLEAIIEAIRDMQKEAFGTKPKAIEKIATDIKAQVEDLKKKLKSGDKDPIINALKDLKDAGLASGQWNGNDGRQVDGLLRIYEDLQMQSGKVPDQTGIIGEAIKKIRWELLKLGYKLDNLFTDDDILDKLKELQRKIGKDAHIDGDNLRAICSIIEKLQNGQLTRQPTVIEGAQEVIAKELERLQGELRNGNGNGVINAIENLRDIGLSENTWVKAEHNKGLQLIENELKEQQESLAQQPGQFNSGVEKIITMIAKLRKELIDGNSGKDGVIDVLVRLKDNGLTEGEWEETGIHGLGLIQKEVTKQNKKLSNANKIIDKATDSVLSYTQSVLKTAKQKLRDDIATDDVLDNLEELQKKIGLIGSNDDATLRGIYKKISGLQEDAFTNNPKEIEEAKIAINKELEEQRATLQKNVTDPLKDLVTNGFGKSDKWNGNAKGFDNIQKRLNTQNDTLSQQPQNIQDGINEITDELKSLRAVLQGTGDDNPEKRGVIKNLEHLRTQIGNKDNKGLKKIKSEIDSLNKNQIPVITQNLNTMSTEITNAAGQLGLNLIQLGDPHIDVKLKDIQDGFDNLRLTDLAEAIRLCDDFLNKADEMEKNTIIALLKHVDDDVYDAIKDLTKEARTLYVDSVKEALELFVKKVEEDLEQLPNEINRERYIGYKGFMKYLQGSLTSDLTGDEQSVAELSSAFQEVFEQMEKYIRVEITRLHDEQKKEQNPSLPPTEEPYTPKLNDVYEALTALLAYLRDNDDGADKLTELVERLTKALGDFVPSDFKHLCTPLLDTVSRGLTKFAAEFGNTYLSTYSGQRCREEHSHKYAKVFLSLIPMTHKALNKLMMKCEGEWKHLPISMFTAGDRDNALGNYLTRCGYRVSSSRGEQDGELNNVFTGGGIYELLFTPIESVDIEMMIDGDPMKNGINFVQIISLLYNLLCRYFQVCHIPVPPEPRYPCTVRDMLSWLSGLQYTMVADKLPGHCKALLNRRCHDGDTPNKEDPIMAKCIGELPIIIASACSHSTALLTAIQGNGHGFDLAAYPYSVDFSNNRARLHYPADPDALLEMLRDITCRLSKVLYFLYSQCCRSTARVKGWRECAYGRQVQSNHWQCKQIGTYPSTISTTTAATTTTSSTSNPGCPPTSPLQSFLSDHCQGLLPHTLTAADMTIQCANCAANQPGQQCLTPLGFWDLGFAASISGTGWDLAKRLGDMCRDADSCLFVLCRTLFLLCPTAPSSLADMFSLFTQVLRRWDSHDRVQHRGGTYTDASDFISHLNTDGIDSLFPLWKELHGSYENHKLTSAIASLAGHDHISHDALSNLFNDFTCKSPSGCAPYLQPLGLHARHTYPQKHARLYITWIMYMAWQFWELLFDLLQALDNIDCTASGCATCPCKPGIHGGKDTCHCPSIVHCAGPLPTLYRHGFTYRNANLLVTDNRAMRCGDLNAQLKRALHSDHFTELFRQIDQLMWHIRMPFFYCFIALWSLVALYILHTSLYRMDVLRIRSHLLTTKASHLIDVKALLIPSRKMLSLYNASYFDDDPNELLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAS6</accession>
    <name>A0A061DAS6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RIBOSOME BINDING PROTEIN-1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766981.1">
        <property type="nucleotide sequence ID" value="XM_012911527.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAS6"/>
    <dbReference type="GeneID" id="24563336"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110920"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1609" mass="179869" checksum="C5E816E83558D8AB" modified="2014-09-03" version="1">MVDKGNIPEFRTLKECLEFLEWLHHNRGAQGQLANRLMRLLNGKYNTVDQQQIEPALSQFLTNVSKFHTKLCKNPQRSYTGERKAKNTLNALLQCIPKVLAALYFLRYNVDDGFTRVGGGDWAGETVGMIELYAARGPEFVRRMIASAGKIDRYLIAQDDVEYGVIPGGFGAGELQPGYKNGYSPASAMAGDIIKILNKETNKNNLLLDVYSTTVLSTTGSDTANIANALRLVQDFCRIFGEVRDEQDFRNHLYSRDKCINLDELKRQCKKLIVPLEKIFTKDRFSFTGYAREYQYLTKENIAKKMASWFKTHLNAVNEKLKRIDTQSGVIKKPRKDNLAAYFNKHFIPYGFTFYGYDFGKGSSQQKILTDNWVNVINELKREGDGLAKLKTILDGEGCLMEEEDDNEVEDEEAKEELEIPDEDLEDVESEDHTPFTKPDAAKPVVTKAEAAKPTATKTEAIKTEAAKPVVSQSEVTPNQGKKSEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVDSPQSQNNGQSEEKPGSSQVAQAAQTNTSSDSRGGSESPGAHDPSSGQGPGDQAATSGASQQSGQKAQPGSGDSKTASSTAGSGPGGGGKGDHSRDPVTCDGGISATLNGQNYCQPKSHWGNRTPFVPTEITEKMWDDFKNRHHPTTMQSVPSIHTPSSSQPLHYVHGDRVVSQRQPFETRKRVRGQIGQGELPKVTGLAIDDPFFEQQRIIENEYKTVLKDNAYKWQTDRMKFYDELQERLTREAETEKEMKEEQRKVERRLEMDAKYKTAIERLTKQNLQREADAKALEKRFEEATRKTDERRRQEEAEEREKQKEEEHRTRLQQQAYYDHANSLNGKPAPDPTDFTLMQNEAINRSRAYKEAEKIEREKNLELKKALYAAQKINLPQHIPKPRSIQPPLVNLDGHASVFVNQMEGIPLSSSSKGNDNVSGLRQITFSTSSVPTTATLSGQTPHNPTESPATATLDDSIIPAFTDVTAINIKTPADPNKYYYGEFTGNVVKDHSNVTRRKELAANAFKVQRKLFEQREPQLLAVDNQIKQSVQKKEEDVENWQEARRSDFLKGIQRDIQSRVTSADGDAVFMSGNPITYQKPVLVIGQVVKNNPDTNGKRKQEAYNILRSQNFDVTGDKILIPNIPPKPLPLLPSIGIPAGKPLKEAKQIPPLPPLPYPLSVPAIASEPEGIDLTKQKRTTERTPVILPEVIPPLTGQLDVLPMENSTDFSGSTIVHTPAHIPTVYIPQDSAFETFVPSEPTGDPIADPKTKPPRKSLTPVEIEAHPGVMIDEPICQLYSPELVTKKVPSTDHSIAPPRTVREMLCWLSDLPHALGYANLINYILNLFEGSESIEAIPESISSDDVTEALSQSCSHASSVLAGIEGPVPIDLNKLHYERYGAPLMYYSEDPYTLLCQLLSYVYATYHQLSFLRTQCRRDSDQGGWRECQYGKNVKASEYWLCTKDPLDPMKLQSHGCDPSPLQGFLTDQSDISTYWYQRNDVCQKSRIKMGFLQKHFRDKHKHGFYTYNLLTGACYNNVDPLEKLCRYLVCLTRRTPRTTGELVSFSHHIGNELQGMCQGCLYLAPPSPSRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAW4</accession>
    <name>A0A061DAW4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769323.1">
        <property type="nucleotide sequence ID" value="XM_012913869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAW4"/>
    <dbReference type="GeneID" id="24565678"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310400"/>
    <dbReference type="OrthoDB" id="10485851at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="11995" checksum="6D0D22D6F6949F22" modified="2014-09-03" version="1">MVDSSSANLASGSNVSSTRSAKTQGSVKAQRQQDNSDELQFVKQHQGINRTRVNTTDVDVILEENAKLIQQLRHPHLTKDSYRYVQTFAQLQRNLVFIARLADQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAW8</accession>
    <name>A0A061DAW8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769987.1">
        <property type="nucleotide sequence ID" value="XM_012914533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAW8"/>
    <dbReference type="GeneID" id="24566342"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402890"/>
    <dbReference type="OrthoDB" id="366618at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="235" mass="27195" checksum="10AF1C4EC33E1558" modified="2014-09-03" version="1">MQLVITTVGILRCINSTLESYFAHELCKQYLLTSGRKKSHLFCYSKCRNKMLKPQDNANHAKPQNNVNQNDNLRDMQRMLYHSLTDVPRNLKECLDWLIAVKGTSKFNTQALGYALYNFLVDKPVGMKYVPSVEKVKRLSREFMQKKEFKDLPAVGDLLRRFTERMNKTDFVDIKRFFALHESDYENIVKLNGVTPDSIAKDVDKIADGCEQFLNEIKTPGQYESAYSSEATWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAX8</accession>
    <name>A0A061DAX8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769997.1">
        <property type="nucleotide sequence ID" value="XM_012914543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAX8"/>
    <dbReference type="GeneID" id="24566352"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402990"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="27744" checksum="3F4BDFC4BC226E67" modified="2014-09-03" version="1">MVYNSLTNVPRNFKEAIDWLVAVRGDDAKSNVAALCAALFSSLADKTVDKMEMPALEEVKHVTKTFLDQPELANQWFVGGLVKRYNDLINTSPGGLAKYFRVVDESDKNVVKGKGITAGAIVENLDKVVHGTEIFLDDIKSPGEYESAHSPEAAWSKSCTQKAEDSAAVFVGIAPMLRASMSSLELASFLTKLRLPPFITYKRMQQLIQALGYVKPERRTGMTASYVGRALGGFRYETTNFIFDLAGFWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB01</accession>
    <name>A0A061DB01_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0310700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769353.1">
        <property type="nucleotide sequence ID" value="XM_012913899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB01"/>
    <dbReference type="GeneID" id="24565708"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310700"/>
    <dbReference type="OMA" id="DMWSDDI"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="406" mass="44765" checksum="70DD89177215FBFD" modified="2014-09-03" version="1">MILDLSGQSLYSLWDSAVAKSMDGVGLSFGDVRELHVQMCGLKSLEGLERFVNLRVLDASNNNINAFKPLWKMGSLRTVKLRSNRFKTVCLRKAGEATVLATADEVDYPITVVNTAEYSLLDLEANDITCVLAEPDTAATVECLLLANNRISEISGLSAFSGITLLDLTGNVSVDAEAILRIPFGSGPRIFLQECHITNEHRLMDLVEQDKEAELVVPGHITLNHPRVVKVGPIDLGKLLQKEFVEYESEFADFRFAGDQLPRELKTPRDYSDIRLDAAHFVVRTHCPRQHIETITTMVDLSEADKHGFKGRADTAVSSTLGSGSETNSPLSINALDTSTDQDDDTHSPKSFIRGKAYPVDDNQHISMVRGGRRVIEAAWAERIERDLSSHFAMPDTIVRPTDSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB49</accession>
    <name>A0A061DB49_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767141.1">
        <property type="nucleotide sequence ID" value="XM_012911687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB49"/>
    <dbReference type="GeneID" id="24563496"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201120"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600760" evidence="2">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="224" mass="23322" checksum="A54A9A5C4746A5A0" modified="2014-09-03" version="1">MGWQLQRLRGLGAAVVVLQLVEGTGSGSGSVAVEGSGSGSGTCCSRLRGLGAAVVVLQLVEGSGSGSGTCCSRLKGLGGERERWVIGGSGVTVVEDVRQTIAIAATCVVENVIQYVLNVASSRKIAEVDSPAAILRDVQSVTEADVNVTVVTIDAIMLVLLLRSVNSIPPPHTSGQQPSAVTSDSPSSPAPYIIVPVALIIVVICVMIYFRIRPFHRVRYLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB2</accession>
    <name>A0A061DBB2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3B subunit 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770172.1">
        <property type="nucleotide sequence ID" value="XM_012914718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB2"/>
    <dbReference type="STRING" id="5866.A0A061DBB2"/>
    <dbReference type="GeneID" id="24566527"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404720"/>
    <dbReference type="OMA" id="NMIANDS"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="290"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="554" mass="61894" checksum="379F8EFE5627C722" modified="2014-09-03" version="1">MGQDSANAGGQSTVLRELRKRSGSAAKNYLKKLKRKQKPVGEPELAEKQSRTARLRDVLRDHFGDLEALQKDAESVDVEYVVPTGVGGEFQEVFDRFAQLERISLDLEPTPEEPEAPVENEFDSSDEDEVDESRRTMGSKKKLKLMNRPTLAQLKQIADKPEVVEFWDTTAADPKFLVWLKAQRNSVPVPSHWSEKMRYMQTRRSYDKPAYKLPPYIEDTKIAEIRSALREKEANKTLKQKMREKVRPKSHRMDINYQILHDAFFKYATKPAMTRYGDVYYVGKEMELRMRHYRPGHMSDRLKKALGVGENAPPPWLINMQRFGPPPSYPNLKIPGVNAPLPEGASFGFHAGGWGQLPTDDSGNPIFGYIDSTYYEDGHINKELWGELPKDETDDDASEYSDSSDDEKAEEGTAVVAPSVETPIPVVSTGLDTPLDMRAPADPPRAVPRKAYTVLEPKATNRSANALFGSQITYSMPPVATPITPVTGKAGAATPLGGMVTPSLQADGAMSADGVMRQLKFYENKAKSVQEAAGQIVTEAAEPKRAKKKKEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBC5</accession>
    <name>A0A061DBC5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767231.1">
        <property type="nucleotide sequence ID" value="XM_012911777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBC5"/>
    <dbReference type="GeneID" id="24563586"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202020"/>
    <dbReference type="OrthoDB" id="366393at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="367" mass="40164" checksum="36AB11E5A031A471" modified="2014-09-03" version="1">MTSLAVKPTRIRGGVTLCCYGSTKAQRLANALRPQERTSVYDAGNYQTVAKPAYGAADREWSYVNTDVYNKLLEKALKRNGNVKAARRSPVSIGSKPEKHAKVLDALNDAFWNAVRERNRNSVPGSITKRSSATTQDRIAVPRGNASSTQGAEKRVRTWLKSPVSRGAAYIDDLPYVNDLPLTVWELGTPRYEQNTAGRGDGSPTDDRGANANKTVVNEGPMESPIYVNADVIGRSEQSVVPNEYRLDLDYANQSRIGNFVDTFDGATAPHMGTAAQPDVNMDTTMELNTPDRLVLDGATLDAKLGAALMPEVTPVREERQAPAPAARRDRSLKPKKHGIRPTLRSLDLDSISGYFVVNASADWEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBD4</accession>
    <name>A0A061DBD4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770197.1">
        <property type="nucleotide sequence ID" value="XM_012914743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBD4"/>
    <dbReference type="GeneID" id="24566552"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404960"/>
    <dbReference type="OrthoDB" id="2193044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="186" mass="21734" checksum="A0516C58EC7A4882" modified="2014-09-03" version="1">MLIYVQSVIPSAHCFEPLIGLPNKQSATRHRSKPWICLIPSGCLRNTVTIVEIGITNQDNLVDTEKFKKQKYEDLIEDLKARQFNQQTETRIITYIMTWEGIATKEHRKYRRDLGISDRMEAHTQRLVIQDTLNSDEGHETERRLRFRRRPSGPNWMDACMDGTSDDRQWTDSEPADGASVRRQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBD6</accession>
    <name>A0A061DBD6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0202120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767241.1">
        <property type="nucleotide sequence ID" value="XM_012911787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBD6"/>
    <dbReference type="STRING" id="5866.A0A061DBD6"/>
    <dbReference type="GeneID" id="24563596"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202120"/>
    <dbReference type="OMA" id="KPQDGIV"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="191" mass="19925" checksum="AFB141E8EE36DB39" modified="2014-09-03" version="1">MFSRGRGASRGIRRGGSSGRGGRGGGHAGGAGGYTGPPAEVIEAGTVVHDCEEQLLVKSTLQSTVPYFNGRIFLANKQEIGKVDEILGPVNDYYFSVTLATGFKARSFEPNSTLYIDPQQTLPVARFLTKPGTAQAQAKKRVIKDQSFKKPGLSRGGRGGRGASFGAGRGSSAFRGGLSRGRGGSFRGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM1</accession>
    <name>A0A061DBM1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767331.1">
        <property type="nucleotide sequence ID" value="XM_012911877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM1"/>
    <dbReference type="GeneID" id="24563686"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203020"/>
    <dbReference type="OMA" id="NMCENPS"/>
    <dbReference type="OrthoDB" id="349484at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="250" mass="27218" checksum="24D051930C8E63D4" modified="2014-09-03" version="1">MGCVEASSDCVVPSDTQVVGLCDVDLKCLVDEEESTCSPFSNPPGLRNSESIFSDDPNYLWFVKQRAEMLRGPSVSSRGNLCRCASDVDSDAGSTCVMVNIQHDTCVNLCDNPSDMWHGLKMSDGTPVVIRSKRPRARRYVGKKCRVFGAEGEATSRTAADVSPAAANNGLFAGLNGPINYGAGFLSLQNYVGRGNGASVIYRVMQVDARLAHSSRRKEIRVRQRRQHVQQHLAKARGIMFKRGTGTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBV6</accession>
    <name>A0A061DBV6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770244.1">
        <property type="nucleotide sequence ID" value="XM_012914790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBV6"/>
    <dbReference type="GeneID" id="24566599"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405420"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="282" mass="31582" checksum="E28099CC6DB19DBF" modified="2014-09-03" version="1">MVYNSLTNVPRNFKEAADWLLALKGDDVKNLEAIGEAVYKFLVDKPVGRIHLPALEKVKRISKDFLEQRELRNYWFVEELLKRYNDRISKTPGALAKCFRVVDDCDYKNVVKSKGITAAAIAEKLDRIVNGTEILLDSVKIPDEYKSAYSSEATWESSCAKDPEACATIFVGIAPMLYAGVRCLHTATIAALLRLVPVTKYEYGLEKTMKALGYVEPESRTDMNMLEVDAALRDLYTSGVLTLCDLAGFWAFYGLESSVHEGEPSAEPSLRAKAREFFLGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY5</accession>
    <name>A0A061DBY5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768590.1">
        <property type="nucleotide sequence ID" value="XM_012913136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBY5"/>
    <dbReference type="GeneID" id="24564945"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303080"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="10084" checksum="852F9DD6A68FCD24" modified="2014-09-03" version="1">MAERAPNLSATRQLKALKRFEHAIREALHLERKAQRRSRGTCNTLALNESAVIAVALVTLNFATTYQVVTSLMQGTEHHHEAAGEVVVDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY7</accession>
    <name>A0A061DBY7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770284.1">
        <property type="nucleotide sequence ID" value="XM_012914830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBY7"/>
    <dbReference type="GeneID" id="24566639"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405820"/>
    <dbReference type="OMA" id="HESEIMD"/>
    <dbReference type="OrthoDB" id="10571511at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="267" mass="30213" checksum="8A8505EFF48F0DAC" modified="2014-09-03" version="1">MIIAVFAWNIQTQKDHQLVNSLHLLVNELTPTHLVISRSTAENLLKNLHHWLSATGAAISAIRQEMIHADIARQNTLMLIQMVTAVLSIIKAALSPETLDKNMTLLHCIVNTCTMPPIEDLLFDIKDSKFDATSKLLGLEEMRPKTIELLEFLSLILRTFMGYKLNSMYELNNTKVRHADLNITLLQAGYGNHSVTLVVSNVIREIYESDNQTKSALALAIIMDIEAPSPPPSPLTDVMQYHMSQIWIAAYRNQSRHTLWRYDLGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC09</accession>
    <name>A0A061DC09_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">-Vacuolar protein-sorting-associated protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0406070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770309.1">
        <property type="nucleotide sequence ID" value="XM_012914855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC09"/>
    <dbReference type="GeneID" id="24566664"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0406070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0406070"/>
    <dbReference type="OMA" id="LEIWHKI"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="28287" checksum="C220A350C0DCB4C5" modified="2014-09-03" version="1">MAVEPSGVVGNFRDFPPLYTEQINDATLSKQLEVWEGLICWQFNSNGLHIINSNIMDVYPFSNTKINRRVSRDFMVLIAQHMVERGFGFYLHSITEFCKLNDCSVWGALCFGKTGKSNKVRSLHEQEYQKIISKAKNGGSLVENLKERRKYMVTNTIAVGVFGKTIDETAEEVLCYLKLQLSGNQVETPYYLFYAERESTRQFRSWPEEHVAFIISTLATQKRIVVTANETVYCKNLNSKELGVQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC10</accession>
    <name>A0A061DC10_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0400240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769718.1">
        <property type="nucleotide sequence ID" value="XM_012914264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC10"/>
    <dbReference type="STRING" id="5866.A0A061DC10"/>
    <dbReference type="GeneID" id="24566073"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400240"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="333"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="630" mass="70233" checksum="8B31C6E5C058549A" modified="2014-09-03" version="1">MEEPTKQVNNPVGSIASVVRPLRSDVRGASSFVGGAQDLQHGITSIDTMSTYRSDIYNEILADVKDQHGKVAMIPNDYSLPIGSHANDCGSFHSTMESDNHTGCRYTRCSVVRDEKDAWAANSTVLPLNRHLNDKRDGIGVNYVRNADDHDPLLVTGEAFASLNLKCNSMWMHRNANSQIYNVEGSKLKPSTYLRRGLVSPQFHKPGNLIFRHNKYDKDALTSNKGCDVELSSSPTRCRDASTSPNDTPFLQSKTSKGFFWHKPFGVSRKDKVMFFRGLPYVETLNPGVQKSWHLEAISALTRDQYASLKMTMFRLSNGSTNLDPKLLLILSSGSWEVLQEGTFGTVYIGCVEGMGNCAVKVPVSVMVQQDPVGVMRRYINEWDILSRCDHPNIVKLRGGLIFGVFDIWLCTELIRGADLHSIKYGEHTKRFISPKVGLKMCRQLADAILYLHTPTEERGKIVHRDIKPENIIVLPNWDIKLCDFGDACENSDGNVDNISGATWLYAPPELLTHKSIMVDIVGLEGNARRVPNELSEKWDIWSMGCVFQEMFGYSGPFHYLVDAQDKPARICEKMVASAIKGLVPHIPHALAHTRMGQLIAQCLQNDPNARPSAAQICAMLRVPDTALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCI6</accession>
    <name>A0A061DCI6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0207500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767781.1">
        <property type="nucleotide sequence ID" value="XM_012912327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCI6"/>
    <dbReference type="STRING" id="5866.A0A061DCI6"/>
    <dbReference type="GeneID" id="24564136"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207500"/>
    <dbReference type="OMA" id="MGRHPET"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="226" mass="25003" checksum="6EB94F4CE1C10D15" modified="2014-09-03" version="1">MEEEELRKKTLVELRAMLSERNMKTTGKKEELINRLLGEEKEESTGASSSNLTVMGRHPETKALAEVELEETNENVEDDEAVKKAGGNSSPDSPSSPDGVSIRASPSSPTKTGSPKEVAKEEPKHVAAGASMPSEIGALTMEERMALRAKRFNITTSDAKPAEKRSQSSDGRQKRRRGSRGGMTQAERTKRRLERMIKRDGVKGEVPLDDDERARRQKRLERFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM7</accession>
    <name>A0A061DCM7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphoglucomutase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0403700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770068.1">
        <property type="nucleotide sequence ID" value="XM_012914614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM7"/>
    <dbReference type="STRING" id="5866.A0A061DCM7"/>
    <dbReference type="GeneID" id="24566423"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403700"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="7">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="9">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="8">
        <location>
            <begin position="363"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="6">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="607" mass="67314" checksum="22F1564A106F31A3" modified="2014-09-03" version="1">MPNVGSLPASGAEAEDFISIRPGPDIPEGYVDLDYGTSGYRGVADTPPNHLDHVVYRCGALLAALPFLRNSKSLYNVKLSLAGPLSSVVVAGIDRVQSAGAVITASHNHATENGIKLLEADGNMLETAWEKEFTALVNFRGPISHAVARVLKKYGVVRVQRNRVPYTILVGHDTRESSPKLAAIFKAGVEAMADVMRLERITCVVLGAVTTPTVGFLLNNSLLSASNDDMYVEALRRSFHATLDSLVALGCIKRSLKTDAHQSLFYDCSYGVGGNVVYKLFECLREIAIIPHLCHSPIWLGEQMQHMLNHECGANYVLSEQRPPALVESRITVYEDKWFCSFDGDVDRLVYFSPHKGTIRLIDGVRLLLIKMKFLNFALSNWVREGDEVLKVGVLLNHYANGAALNFIKQLMTEWNEADPRVHWSMQLCKVGMKNMQAKVPNYHITILYEANGHGNVVFSKDSPLHRDNGDCGYRRLMINVSAMFNNPIGDAIANSLFIELALRTLELSYEDVLQFYEELPYVNVSARIPSEKRSIFRTKPDDDSVLEEPAELMRLVTEAVAKVQGARAFIRPSGTEALCRIYSEAPSEAQARALANVIVEHMTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCT3</accession>
    <name>A0A061DCT3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770173.1">
        <property type="nucleotide sequence ID" value="XM_012914719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCT3"/>
    <dbReference type="GeneID" id="24566528"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404730"/>
    <dbReference type="OMA" id="HNRAMDI"/>
    <dbReference type="OrthoDB" id="10330401at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="127" mass="14035" checksum="CFC1072AED7B1AD0" modified="2014-09-03" version="1">MMLSFLSLTSAPPTSTAGRNDEKGVMSLLFHGPVAPRHISFGIEDSNEGVAKEIAIAEGSLNISRVQRAVDMTTLENTLNRLQENEQNQLDAVQESMFLQNAQIDELQRFISRPPRNTTAVSKHVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCU1</accession>
    <name>A0A061DCU1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">-tRNA-specific adenosine deaminase-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0404870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770188.1">
        <property type="nucleotide sequence ID" value="XM_012914734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCU1"/>
    <dbReference type="STRING" id="5866.A0A061DCU1"/>
    <dbReference type="GeneID" id="24566543"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404870"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="150"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR98002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="314" mass="35491" checksum="46D63240DC75BC9E" modified="2014-09-03" version="1">MGDSGGGCVPSDPDLAAEYDVQEVLGEQFTRDLEFLELRAVEIDRCNTQTALKLTEATRKVLLPGNLQYVRMCKPIDQQRLLLIYGRDSEAPFRSEFEQNGIQIHSERTVKVPRHSPSTLEQYHQWSKHWPLKYLKPSVTPLKITKALKDKMLGMIQTALKESRNNQGKAVCIITHNDRIIAKAVDERDANILDHAALLAIRKVAQLQKNDPKRMYNAKRRFTGSHNGSDNAAEPEAEEPADDVEIPDYLCTQCEVYMSHEPCCMCAMALLHSRVASVAFFHPNALIGALGSVHSIHNTRQLNHHFRAFAIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD15</accession>
    <name>A0A061DD15_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768051.1">
        <property type="nucleotide sequence ID" value="XM_012912597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD15"/>
    <dbReference type="GeneID" id="24564406"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210180"/>
    <dbReference type="OMA" id="WMIRILK"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600806" evidence="1">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="117" mass="13272" checksum="2BE31BE566983172" modified="2014-09-03" version="1">MVYFFSRSVLLVVVVSLVGRVGLALKEKATAKSRNAFLDFFKLTGDVVPSTYPVLKFNQSANNDSTFAALRRRELQELQDEAARLLPLQRRNFEGISDTLFRQSRSVDELATAMERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD86</accession>
    <name>A0A061DD86_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768236.1">
        <property type="nucleotide sequence ID" value="XM_012912782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD86"/>
    <dbReference type="GeneID" id="24564591"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211920"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="88" mass="10144" checksum="4EF7AB7B3FC0DC32" modified="2014-09-03" version="1">MPMVVPNVVTWKWIVERQYNMHLLALGISDRINSHIQRDVRATNSYVAKSDVKQRPSSPNWMDARMDGTSDDRQQTDVDPATGFSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF5</accession>
    <name>A0A061DDF5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769535.1">
        <property type="nucleotide sequence ID" value="XM_012914081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDF5"/>
    <dbReference type="STRING" id="5866.A0A061DDF5"/>
    <dbReference type="GeneID" id="24565890"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312520"/>
    <dbReference type="OMA" id="YTIPRWE"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF1">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49081" checksum="511FA8B3965C2693" modified="2014-09-03" version="1">MGSVSGDSILQEDIEFYDSIQRYTNNQVDITSEDSGFYPYDIRIVKRHDIRNMAYMDTASTEVYVSQNVVRGDPNSAIDADRLMTVSLPYDDECDTDYENSGSESTLASQYAQQGQENDDENRSTGTQQKAFSINMELAIYMLVFVITNSAQPLLICLLRQKGGTPNGTYTFLIPTYMAMICVGYYPTTKSIWEESWSYPLMLSGLDIVHQVVEKAGLVACGPSIYTIASSTNTMFLALLSSVVLRKRISGMTWASISLISGAIAISGLTQIEEITTTQILGFLLVVAAALVNAFNSIISEDLLRKKKIEGPNLVCMMGMISLAIFFVWSLIFTIPQRHMLFSSKNAINPFDLSSVLSILFALFISNFFRSSVYYYIVKEAGSVCCGVLKAVRIIIVVAGSHALFSYADKSQAMTTGKFISSLVCSLGVIMYSVEHASIQKPKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU8</accession>
    <name>A0A061DDU8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2 8">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0304930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 8"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768776.1">
        <property type="nucleotide sequence ID" value="XM_012913322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDU8"/>
    <dbReference type="STRING" id="5866.A0A061DDU8"/>
    <dbReference type="GeneID" id="24565131"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304930"/>
    <dbReference type="OMA" id="NGLLMCD"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="10">
        <location>
            <begin position="233"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1161" mass="129477" checksum="D51813CFBAE1B0B9" modified="2014-09-03" version="1">MAPPGRLYSVWLEANLGRFLHGVSVRRYTPLSDGRQEQTAVKRDSSSLCSVFSTRRCLNTASAPDDAAPAELLHIADRSCRDQAELLRRVQAAFDSHTPSIVCWLRTNRQSYMRDVDPSTVDLLRNAERFASLHGLLLCDVPPHDLQEHVRSASCLRDLFSPKFIEAQKAALYRHQHLPLLKRPPVDRAVEPLENALNGTKEQPADTCDKMECAAEGEDARVDCVGPNYVNYKRQVLIERQSFAEALETARVEASSLMELEKPSQLPALSQTCEQWVQDIAEFIKLDRLKLTDSVLPSNLDDQTLARATVNIALQLMCFPAYAYNSKGQRGGLLRRRPQQTAGNQVLLAHAAIRLGDEIGRMYARKLASSKPPEAHAKSEPKFDVPRSPETAVTTHSSTSDATTGGLSRGVGTVFDIPKLLTASLSSLTASAFSGASKARVMSNTATGVMEPTPQLHSDGTLTDDQKQWNSKQSAAVGGYLLHALVQSCYVQVDLTTALRQTNSFAELDTSMLLPDVHNAESDHTAIAKKKRKWLNKAISRIRQSRFDAGKVEIAAFAHKVHRHGVKVYGVLEMRECCMIHLRDAVARGLVNLSCLPMVCEPKPWTSVSSGGLALLKHYFIRTQSRPTFDVRVYDLSRVLNVVSAFGRVPWKVNGDVFTVLRTLWTTDTLLPVRSFLPDKSLIEDESETAVSTMERANALSECSLFERRLRVAEDFLLEPRIYFPQNIDFRGRMYPLSPHLNHMADDVCRALLKFAEKRPLGERGFYWLKVHLSNLYGMDKVPFSERVEWVERNTGVIQQLVRAPFSEVSQSFWQRAECPFQFYATAIDYVAALGSGNPHGHLSDVPIHQDGSCNGLQHYAALGRDLNGGAAVNLTPSDRPQDVYHQVLLEVIAKVRAEYSSTPGSANDPVNSKSRMARLCLEHGILRRKIVKQTVMTICYGVTRTGAVAQIEARLKELSTLESLDPHTVHNLAGYIAGKVLGSINTVFAEAMAIKKWLDDISAAHNRLNVPVTWISPIGLPCEQPYCKAVTKVVRTPIQAINVSEQAHSVVDKRRQKLAFPPNFVHSLDASHLMLTAESLLKVGLSFAAVHDSYWTHACDVDVMNVAIREQFVNMYREPILENLYHSCIKRLRGEVVIPPPPRRGQLDLDLVRQSAYFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDW9</accession>
    <name>A0A061DDW9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768831.1">
        <property type="nucleotide sequence ID" value="XM_012913377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDW9"/>
    <dbReference type="GeneID" id="24565186"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305480"/>
    <dbReference type="OrthoDB" id="364501at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="139" mass="16071" checksum="44D464C99C6E5EA9" modified="2014-09-03" version="1">MTSDVMEQLASIAAGGMSLEEARQMRETQARRLEAKIERRKAQVKETMKALRQHKTALATRLQKRQAEIVELKNEFDMVMADYKLECRKLAEQDSKDLHEFYLWAKDEIAKCAQSALERAPVEDNTEIMRALNVILKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDY8</accession>
    <name>A0A061DDY8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein serine/threonine kinase 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0402770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769975.1">
        <property type="nucleotide sequence ID" value="XM_012914521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDY8"/>
    <dbReference type="STRING" id="5866.A0A061DDY8"/>
    <dbReference type="GeneID" id="24566330"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402770"/>
    <dbReference type="OMA" id="RHHIQSF"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="171"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="500" mass="59403" checksum="1D788588FDCC6C6E" modified="2014-09-03" version="1">MYRRSYSSRRRRSSHSRAHRGRRRHRSSSRGDRGSRRRHGSYGSRSSSSSYRRSTSRLRRVDSGHRRHSRRDALRDSRRCYDDRRDSHKISDSRYERRDVSDHDSRRRRYDRRTRDRSVSVSRRRRSHHKDQWHRRHRSPTRSPSDHKRYRESNDRIVHFKWEPGMMLDDYRVVQKIGDGTFGRVLHCEKNGEHFAVKVVRDVEKYVSSAKIEVDILMDIRKVDVAGESHCVVLHDHFMFKRRIMCLVFEQLGDSLYDFLKRNDYKGFFMADIQKIAYQLLKGLAFLKKNRLIHTDLKPENILLTCGREEFIEVPFPRSMTGMMTRRPATADIKIIDFGSTIYEDDYHSTIINTRQYRSPEVILDIGWSYASDMWSLGCILIEIYTGDLLFNTHSHLEHLAMMEQTVGRLPASMLEKARTTDGRRYLHPDKLSLNWPDGARSRSSVERVKYCSGIMELVKPEHRPFAEFIKYILNPDPEKRPTPEDAMEHEFLVLTLPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE60</accession>
    <name>A0A061DE60_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769036.1">
        <property type="nucleotide sequence ID" value="XM_012913582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE60"/>
    <dbReference type="GeneID" id="24565391"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307540"/>
    <dbReference type="OMA" id="WVPEFLN"/>
    <dbReference type="OrthoDB" id="366281at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="204" mass="22716" checksum="D07966D0240FBE7B" modified="2014-09-03" version="1">MLLSRDPQYSPPNDDSCDSLSDDLHDYDYDISPLSTGIPVPVFDISDSMSMAEPSFREYKRGGRLAPARSLAAESNRISDDALSVMRDEYYANSAVTASAFDQATFYKLQAEILVSKRRYKEALGAALVAESAEGRSRVIDAVKMICMYQLNDEERFKELKQELTATGLGGLSESLKKQALGTIEVSEWVPEFLNCLDQMKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE84</accession>
    <name>A0A061DE84_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0308190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769101.1">
        <property type="nucleotide sequence ID" value="XM_012913647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE84"/>
    <dbReference type="STRING" id="5866.A0A061DE84"/>
    <dbReference type="GeneID" id="24565456"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308190"/>
    <dbReference type="OMA" id="SHKQLMM"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="114" mass="12753" checksum="137A218A480C9B7B" modified="2014-09-03" version="1">MPWPLVAVACGSGILLGRYLYRRLPAQWKLLSRNPGQLTGVGIMGGRLGRMNLRGFEQKMTYSEACSILNVSSTASKDKIRENYKQLMMRNHPDNGGSTYIASKVNEAKDYLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE96</accession>
    <name>A0A061DE96_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769136.1">
        <property type="nucleotide sequence ID" value="XM_012913682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE96"/>
    <dbReference type="STRING" id="5866.A0A061DE96"/>
    <dbReference type="GeneID" id="24565491"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308535"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308535"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="322" mass="36604" checksum="2CFB8F9FAF556B12" modified="2014-09-03" version="1">MDLNEYSHKNLNHNQAKFIYENEKNYYYVVKSFSDRNVRAALEHNVWATTPKNEGTFDEAFKKCENVVLFFSINGSSRFIGYALMRSRPGNCSVQNNVFCLPNGRQFNGKQFDLLWIRVVELPFSDCVHLKNSFDDGRPVKVARDGQRIDQSTGKELCILFENRFLQKPIPWQPEMYGSQYGAYVINPQGYQCVGVAPGAQTIPPLSGFPVIPISHAPVDLQHIGVVAPYYQVPPVSSPRNQKRSRSGATPQNGQAEKPTDVEGGYRMTEDHALKAAEYNPALAIFPVDLTNLSYEHYISLYNVSHQYWIEQQEPDVKPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEG4</accession>
    <name>A0A061DEG4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0311380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769421.1">
        <property type="nucleotide sequence ID" value="XM_012913967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEG4"/>
    <dbReference type="STRING" id="5866.A0A061DEG4"/>
    <dbReference type="GeneID" id="24565776"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311380"/>
    <dbReference type="OMA" id="IIIWRTK"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="311" mass="32880" checksum="CC534402B2FDCE3D" modified="2014-09-03" version="1">MLLIAGGYEGGLVGLNVDEDCDSSASSTTSTAPSQPSFAFRFICSQGSIRCLALGSDFLCCGGSDETVQVYGLRHRKKHGDLLLSAGCITALGARGSIANGLLLVGDEHGSLQVFDVLKLSLKKQLKGHKSAVTAISVHPNGELALSVSEDATLRLWDLNTCLCVFFSRLNEPAIGVQWHPGGEDYFILFESQLLKLSLSEGAKPSVHKANNTKYCCASWIGDSIAVGCRSGAVVIYPPGEESGTDFGGVHSKRIKAITSLSGRVVTADSDGTILCSAVVSDDSEAPKLVEAWRFNVEMRVNCLTCSTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEK8</accession>
    <name>A0A061DEK8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0313570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769641.1">
        <property type="nucleotide sequence ID" value="XM_012914187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEK8"/>
    <dbReference type="STRING" id="5866.A0A061DEK8"/>
    <dbReference type="GeneID" id="24565996"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313570"/>
    <dbReference type="OMA" id="FEALFNC"/>
    <dbReference type="OrthoDB" id="361275at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="615"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="862" mass="95584" checksum="808501DBD7F81940" modified="2014-09-03" version="1">MFLSDQSHLLAFSGFKRLRLVRSEPPGRRDDHEAAGVDNASCSSQCQYYRWLSDAAVEGDCATKVNLSDTCGIGEVKNSHFRRAMVDRLSRKISDWRASLSDDVGELDVLSSLNTSIARYFLQMYNGHEPYTMRHGFWVSCANEHEAWDFCSRICSNAFWLRGKQPWGTRNRRIYTVDLYESSTSGFPKGCCYSAHGYICCCCQVCQAVCGMLRMDDGGLEPQPRCNALYNIIANNLADILTFLEHNSQQHNIEHRLLCASVDSYVSKRRSQEICNSLWDFKDGRLSDPPNYCTRQLKKGDKSHKIPVNVRNDKSVYGDFGDQVTHGCGEHVSCESVAEELLGDCGCFLFLKGANKLFSEPNGDDVSVNNWSVVVDLLRDYSSMWSAYNMPVYVFCCYEAEADNAPSSDAMVENFGAPDVHIDGAEYMLGRLQCFEHRVDLARSVEERDSRRAHYLTSSLNVAAGEKRDHLLNYLVSLTSGYGMSCLDTIVRMASCEYLTAISDRGRGVSGRDNKLFADIQLTARAFEKAVAIRPPLALSVGLPGLCVLPHNAGKTVGASAGFPPLRVDNGAISVRQGFDSMVLGEPLLANLRDFVSACLSPDEACETPQPFVTIEGPSGCGKTLLSIALAHELRSTLILSSVLDFLRPQVGVSEKLVHSFFSSLSSQFMDVNSVNSQHDSGLLSGNSETAHSLGKASTRRSVPRCVVVLEGADSLAETCGYMRSLLYALCSELERFRDLWEWQRSCSVIFVFTCQSLSSLPCRLREACRSRQHYSLLGNVSTDSEIEACFELYLRGRGTLLDRFRELWPRWRLDAAVMSLRPCDIALLCRTAAVWSVSGVVPLPSSSAVQRLAESLCAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEQ5</accession>
    <name>A0A061DEQ5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769876.1">
        <property type="nucleotide sequence ID" value="XM_012914422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEQ5"/>
    <dbReference type="GeneID" id="24566231"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401810"/>
    <dbReference type="OMA" id="WYHDFIA"/>
    <dbReference type="OrthoDB" id="63891at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43869" checksum="8687BD781F5AFA12" modified="2014-09-03" version="1">MEVERITSYDTASGEPADALDSEHCSKDQLFESKYFTREDFAPFTLPYGTLCGSDGGNTENRDTSSEGSADPKAWAASVFQDCISFIRGNHESNETFEWYHDFIAFTNLQAAVYSDRELLKDGEDLYLILDYTNKHVRNLRSSVAKNALFFVGCIIEATEHDSTLFVAVALRLLPHLFKCSTSEKIVYRKPAIHNIVSICQRCRSSESIAIAWMLMDHARDRSPKICAAATIAMQTFFDNFDTDMLVTLDLEDVAEHFEPCLGGRNAALKKLCSGLVIKIAERLPTDTLHAWVESAASKPNLKKLLKPYVPSPVLSEPSVDEPNDQTAISASSEMLTNNVVSVEVKEVSSLPEEKGEVETTCPAATETNDEPNTAETTEDPATEENEGEHDSAQSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEY9</accession>
    <name>A0A061DEY9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770296.1">
        <property type="nucleotide sequence ID" value="XM_012914842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEY9"/>
    <dbReference type="STRING" id="5866.A0A061DEY9"/>
    <dbReference type="GeneID" id="24566651"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405940"/>
    <dbReference type="OMA" id="AICVRAY"/>
    <dbReference type="OrthoDB" id="372061at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="86643" checksum="F0080CC557AA4685" modified="2014-09-03" version="1">MAPGIWLRQYHQLRYATSAVNHDIPTSRNRLHDYLKDKEVMELTGEIAAPTEQRCHSICDDLAKLSRNRNIEIELLPEKIPISCHEVENVLLSAPKYPKVSFFPDGYINISLARRGSHSDFIRDARDFRNEEVASSSRLFPMHRTRGRKIEEADVKMLQRNLDANLSDIIGLKNPSDLVEMLRQMHALDLSIKINKFAEVSKKISKGLVSMSTRELVDVACLIKSYLGRDYESGSFLIGAIGGRLDKRSGALYYMSACDILACILPILQMQISFPRTKWTILTNSQLLRRLVTDVNLLDANRKADLFILLTVSNTIVQLSEDLAESTKFIAGKLAVEVSDISDSTMHRLLSVIDIFETRFPILRDVLYRNSFHRSRSIQPSQLASVYLRMASTKDVPKHVKNIIGRRLVEITTSAVIDLYCRHLKDGVQNARQLKAFEWAISKKRATLTMRDMSTILMYHSTHGTSISRLNEVIKARFLDLKSTGNVKHDEVLDFVLSMSLVGLHNDLDVWAGVDLVHLVYSTPNNILVYLGYALLLTGQRNRGIWTILLERYAYIESASINSCRILYDSKHYSCELYEVLKIAQVFGIIRDDMESHLLNRALWVLQHTKSQHYAKVSRQRYQTHAPIEEALNLTGLQYSKGVVVDELYEAPFYITSHKIILDPLRESYMHVTTGLEVGEAHLRHTVWHKQGYRPFPLNAPSLNKFKDTNSDTWNIPALAEFICKVMKMEKYGPLHGKVSIASLMRDRSGPSQSVANKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061BLL4</accession>
    <name>A0A061BLL4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0004240</name>
        <name evidence="5" type="ORF">BBBOND_0005070</name>
        <name evidence="6" type="ORF">BBBOND_0200010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK055156">
        <property type="protein sequence ID" value="CDR71766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK055199">
        <property type="protein sequence ID" value="CDR71848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767030.1">
        <property type="nucleotide sequence ID" value="XM_012911576.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770710.1">
        <property type="nucleotide sequence ID" value="XM_012915256.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770791.1">
        <property type="nucleotide sequence ID" value="XM_012915337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24561983"/>
    <dbReference type="GeneID" id="24562065"/>
    <dbReference type="GeneID" id="24563385"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0004240"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0005070"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0004240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0005070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200010"/>
    <dbReference type="OMA" id="KSANNDR"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="615"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR71766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR71848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1347" mass="153627" checksum="13A7AE98C6F3D0E0" modified="2014-09-03" version="1">MESSQEVQLSSQIDEDGDLMVIDVDVPDGMDIDAPLATVGRRECRQPERRHESRKPVQSGVQGPKGKPTNSKGAGRGGESRPIPQASRKRHQPGTTPAVKGAGNKARNGGPQGQKGNNRKAKKTGNTAQTPPVVVCNAGPSSSERAPVCVQTLSTLQPPAGEVVGNGGCRSPTVYSISSDDFMDVDEEEPEQVGPVRESNNSIAPGTASEVALTETAALPRAPEGHAPQAERAGNTPQMPPNYARLNAKLQFLHCVMRQIDGPWCHWVPDVYKAVVTKYQRMPRGGWKVLAEYANEHFEFHKTHKEVEQMARQVVAKAARSQPTDVGEIASLHDVDSYNALQEDFDRIMAQRLREPGVIRTVKNKRHTMDSLDFTAIRSLDLVVHNYVKHNPVTDMGMLAVLYQTAQDCYDKYSAKPSSSSGKKEAAERRIKELEEIGALLLKYKQKVPLEKEDRKRVYRQMDKYNMIADKPQELSYVISRTQEELQKEQDKLKNAKFKKELYNDNRMFELYTGHFYRTLENKQDADESAINEGMMIEYWAQMWVKPNAPHNGEGYLVERPPAENKAGFPTYEEFVTIVKKLRDWKSPGADGIYNYYIKWLTSLHRVIYRLVEEACQQGKVQDDWFYCGITYLLPKNKKPKSAAQYRPITCMSNLYKLTTRCATETLKREVDGRGLRSENQMGTRSNVQGAKEHALANIALNEKHKGKLLATWVDVMKAYDSIDHAYLARVIDNLNLPGWLSNFIKQTIKRWNIEIRWNKNTIMHKKVERGILQGDSLSPLLFVLCLDPLSRHLTRIFPKVELSVTGGRIFATNHFLYIDDLKFFAHEESTMRGMGREVEKFFNDIGLRINRDKSATNTEACASIAKQMEGPETYKYLGVTETSNSLTSDGMFDIILQEICRRTELLAASKLSGKNLSMAINQYALSVINYYIGVIPMDITHFDKIDLAVRRIINAKHGHKKWANTQRLYLPRKEMGRGLHSMVFRAEAMLLRLWLTLSADEVTSTRRAAIMQHFRDTYAHISHIKMHLEGRYGMEFGMEDTTDKSLRDLRVAQNKWLYNRMHVKSTHKVLYAKREDPKLDIEASSLYLTCGILTPEEEANVAEVQDRNLQWMSSSKKCTRCNNGKNVDHLATKCQKLLHLEYTKRHNEVAKRVHSVLGRQIGLPKEKIDAHKIESEVHGKYGWIAYDKTVKTQKTKEYNRPDIILADRRRNTITIVEIGITNQDNLVDTEKFKKQKYEDLIEDLKARQFNQHTKIRVIPYVMTWEGIVTKEHSKYRRDLGISDRMEAHIQRVVIQETHKIVMRDMKPKEDYDSVEDPQAQTGWMPAWMAPVTSGNGPAWIPQPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZS8</accession>
    <name>A0A061CZS8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766104.1">
        <property type="nucleotide sequence ID" value="XM_012910650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZS8"/>
    <dbReference type="GeneID" id="24562459"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102470"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="105" mass="12651" checksum="ABFD86C2E33AAF92" modified="2014-09-03" version="1">MVKHRICRYDDTIGVDYVRDFVALQQRTHLTALKLYHQEVFRKSREIERKFEKLKSSVKGEISDYNINVHRIGNFKPSGNNTLLFYDSEIRSDFHVDVIYWQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZW4</accession>
    <name>A0A061CZW4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0104550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766332.1">
        <property type="nucleotide sequence ID" value="XM_012910878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZW4"/>
    <dbReference type="STRING" id="5866.A0A061CZW4"/>
    <dbReference type="GeneID" id="24562687"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104550"/>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="546" mass="60431" checksum="6F33E1EB9582B04D" modified="2014-09-03" version="1">MEAPETVSEGLVQVSSRSLDGKPLFYNPPQVFNRDISLIVLKTFVESEKERAKECRSSTGESRVGAFVGVNVLEMLAATGIRSIRYLKELGDYVNHIYINDLDHNSARAIAKNCDFNGIPPSKYRAICADGNQLAQMLTPPADILRLMLMNGNIQKIPCGFVPSKTFSAMDAYNSTVERFLAVIAASECSEDVTRYRNVIDVIDIDPYSTATVFLDSAVRCVKSGGMLMVTSTDMPTLCGNNPLVSFYKYGGSSIKATFCHELSLRILLYTVMTTAAKYQRVVEPLISCSADFYVRVFVRVSNNVQQCKHLSENCALLLMCAQCDSFRLLKLGEYSEPKQRPASVPGDLRGTCEECNGRLKIGGPLYVGPIHNRQFVSAALKNATEAHESLPGVTQNAKIIGILTAISEELEDTPLHYSIPCLCQKWNLTTISPSAFKACLEKLGYRASHFHRDPQSLKTDAPNKVVMDILRHHAIEQNKVGSHEFFKTPIQTEGIDLTPPETSTRTAVARWLNNPSKYWGPKKMHRQVATSRPLEAETPADNANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZZ7</accession>
    <name>A0A061CZZ7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766357.1">
        <property type="nucleotide sequence ID" value="XM_012910903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZZ7"/>
    <dbReference type="STRING" id="5866.A0A061CZZ7"/>
    <dbReference type="GeneID" id="24562712"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104800"/>
    <dbReference type="OMA" id="NWHWIVD"/>
    <dbReference type="OrthoDB" id="360074at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="765" mass="85430" checksum="4E64A151AE0F659A" modified="2014-09-03" version="1">MTEQHPSTLPPPNAERAKGDASDEYAADDTVSNTGQNVQSEPKAPLDEETQLALDEVESEISQLLATGIQDTSVLGRHDECEAVWQRIRQQHGELRSTVDNELGIDPQLRDVVRAFAEGSVLPISGLITQLREHIAAHCKVANQDIGSTQLDTVVPLLVTRKNLGEAFDGDNEMDRLESVRAECMWVWESPSVDVFPDTIQERVNAAREARNLISRRYITLVKVRDAINSGDTAARNAANEELGAIYKKMLLEREKRERLEAVNKTKKVKKHESSPPQAKVSQAKDSKAAPNTKHEKATAKATAKPHAASSKQPNMLLNWLKSSSTTPAASSIGDDNAGNAPSTARSSPPATKAPTSSSGTGPSLQPTEVNADDYEDMGASEVQMVEIAKLMEALPRNRRQQSSPNASAHGVSCDTAERVSTADDGDGSSPDFDEFKKMCEDHRNAWMRYFTYVNTNRKFYVEASTNTASTDEGAAEPVSARESGSKGFVVDDLVNNIRDTIYGDKALKQERSARLFYMSDNEWKRPSMRLLISRSSQIVKPTEPLAIEPAMDYYGDSDEEWFEQYDVDDVEESGSEEEDDDEDENDWIVQDNPQQELQKHTLNLCEVVKVYCVNKNWHWIVDGVPQNNDECCSIEEAKKNGMDIAPCDYGFGYEGYTQNPISEFVSNMRGHQIIMTKEDVQEFLKLCHGKHTKKEVLISEFKNKKPFCSTVELREKFKKYICRMKVDHTPQRWLVTTEAAILFGIRHELDAILAAAMEQVLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D096</accession>
    <name>A0A061D096_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766437.1">
        <property type="nucleotide sequence ID" value="XM_012910983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D096"/>
    <dbReference type="STRING" id="5866.A0A061D096"/>
    <dbReference type="GeneID" id="24562792"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105600"/>
    <dbReference type="OMA" id="IIPQYMS"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1186" mass="134178" checksum="7E18C51E6444EC21" modified="2014-09-03" version="1">MSDSNSEDAVAEPRSKLIEWIDQYTSNDSETRCCDLRNHILVAVVNSKHLAFVQIVVRTYDHVCFYINTTNVHQENDPVRKRNICRLLYDVISRTENLFSAECLVPFLQKCLTVTVCTNFAILAIRALLERHIKIEGGTIHVLNILQPLYDALVAQNIASMAQQPRMDFLWITHFMLQLHRSKNLNLRQNFVASFCSAVLGEKDPRNLLVLFDLVAKLCEDDLADHDVDLLAKLCTPYYPIQFQPPKNDRIGITPLELKQRLLRVFKACSKFGPHAMEVLFDCLYSGYATEDDHAVILGDTLWFIKECAPIYGVPCYSYNLESFIDVLVSEFFTDAASRKNGNDECLDDTPGGIIVDGVLSDLESSVFSVTEANKLGMLYYEGWKYVSNQLKIFGDIVKVYMDVVDVYMCKEVVIKLLRTLKNNFTADNSKIADANGYAAYFLDILCGMPKYHDLLLEYVFVPLCNDIIVMFAQFKKGLDSEDSLCKQLALMLPVVTNTLFAKLVSYCVQPIPTIYAKQIVVGALCSLQLNDNTICSRGLKLLTLAISSSTCPVLEHVLIHCLKESQLFSKKRVCRDGMDIRLYADALLAMLKSHYVHCDPIVEQIRLMMDCLVVSSDIEDCILAYFSNDVDLSHEMAEICAIVLNKSTDKALVKQIFAAYCKCFIHVCENPESKIGHATFVFSLAITANRKTLCALLNEEFSFNQLLGYYKVLSEKAEDRKMSQSVLKLATFIIPQYMSMTLDHPSADIARQLCEDGLIFLLPLLFNHISNEIVAVIIEHAKRDQIKIMELESIGWLLKCWVKQDCNKSEALNFSFESSGDYFDNQNRMEVSRSAINLEEISNSRFSSLLSEGLPSIILSYLLEDASYQTLVSRDMKSHMLSLPPSVISATVARMYPFQVENMSATLEYLGYNPATFIGPSITYSDVFFVDGTEVELVPPLTRMQHKILMANFRNSRTPDASVAKYLINVLSESKDNLAYAVAITSVALRLEHSELLYDNAEIMQFVMQQYVSQWPKLDAVKNKRAAVQRAAVVDDSIQTNLHSPYEKWLQREFLFLSQCLLLKVICLLEQSSSSGSEVRHSFDYLWSQKSREAVNLANRCEFEPSYSQWEQLTEVAASVALESSLPVCRVFGILLVHCIVKAAPKTISASNCRSVMKRMSECLGDGCQRARAVAIKCRHNWLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0L4</accession>
    <name>A0A061D0L4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0100160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765873.1">
        <property type="nucleotide sequence ID" value="XM_012910419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0L4"/>
    <dbReference type="GeneID" id="24562228"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100160"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595312" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="823"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="954" mass="107162" checksum="02CC345CA51FA8F4" modified="2014-09-03" version="1">MGCPIVMKFMLALCATLLYSFRPIETFICDFGDPHDLLSNNAIVSCHTYFEFSEFPPVICPRVVNNTEYVWHPQPTKIENGYRNAYVGGNGKIRSVAIAEIVVTDRPVELVTVRSNQSQSRLHFDIPRNELYVINECRLIFICGPRDLFLSDILQRHLDQLESVTQMRQLLWNSATPLAHELGVIGKGLGIFFLYRGGTHLPLQGCGSRPSPLFNADYEVNVDPVTGTRSCVVDPMSNARIGFICEGRIEPADCMKSLIDDKGKVVTAPRPRPYWDFRYYRPWVVAKYFSDVALTPFSGECRCVDPETGDIKAKIQIRQNSEHVCDISSMIVRNRSQPIRGPWCSVVLHPGSTLTIRFPTVDGAADYDNSMLRTSSRQTSINEYETEFLPKDLKTVRQINTYRGFNVYDEVSYQEVLVGDAIELDVSQMHRGEVTLKYHVDKPLTLRSGFNSFLYHWTLKSKNENLAKKIQATVNVSFALTHEHEIFGCDSRQTKLFNEDISRQHCSTKRMGNGIGDTYECLLHNKAHIHQAGIYCRPEERLLPGNCQYTGYDLHSNRIMSFPETVRSITPQPITGFQVLNMEIQNLPVSYACVCVNEHGYETSRLTVESNREESRKFTVRRINGLQKILPYVSLRLNIGLILEGLRSGMFITLQHVSKKTIKLHVGTKLLLSCALGSALQNGSNDTISPTAWLPKLHGKYHYNAIVTFRGLELITRSHNDVIAGSHGGFSVLFNDDHSSAHQALILELRRNAILISKDPVHKKNVPMRFVCGKAAQLSDPSAVSDYALHSDASVQSTSSITDAAGKYAWNIVKVNVETTDPYMQGCGVTYASDELFKPETPKIYDSYGQRKSGCKIDIQAAGEAAFYCPAPYVLEPSYCFEKVLMGGIIMNVKDISKSLVSSRTNHFVTLEFDSARIGSGETLRLKPPLECQCVTDKGIVLSTIQIENYNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0L9</accession>
    <name>A0A061D0L9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">U4/u6.u5 tri-snRNP-associated 65 kDa protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0105120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766389.1">
        <property type="nucleotide sequence ID" value="XM_012910935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0L9"/>
    <dbReference type="STRING" id="5866.A0A061D0L9"/>
    <dbReference type="GeneID" id="24562744"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105120"/>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="11">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="164"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="475" mass="53894" checksum="9F656975BE32FE8C" modified="2014-09-03" version="1">MTLDNLSEGYENRIVLGCDARYGSTTLDRHKMAVERSRMQPIKCPYLGTINRHLLDFDFEKVCSITLSNKHVYACLVCGRYFEGRGKNTCSYVHALQERHYVFINLHDCKVYCLPENYQVEDASLNDISLFLKPSFTKEYVDYIDSKIVYGKALDGTDFIPGCVGLNNLKCTDFFNVIIQALCSVAPIRNHLLLLDVEVIQPPDNVITALVELVRKIFNPKNFKGIVSPHEFLQAVGVASGGMYKIGTQGDPVALMSWLFNKIHCRLKNKKNNASIISSTFGGQLIVMTQDEQGWKEDIVSFRMLSLEVPNAPIFKSAQDKNVIPQVSIIQLLQKFNGRTEHVSAKGLICRYRLWKLPKYLIINVKRFTRNNFFLEKNPTIVSFPMKNLDLSAYVDDRAPDKYHTNGRYDLVCNVCHQGSPAAGHYKIHVLHGPSGDWFELEDLLVTSVLPQFVAQSESYIQVYKRQDDESGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D177</accession>
    <name>A0A061D177_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766038.1">
        <property type="nucleotide sequence ID" value="XM_012910584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D177"/>
    <dbReference type="GeneID" id="24562393"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101810"/>
    <dbReference type="OMA" id="TNMNSAK"/>
    <dbReference type="OrthoDB" id="10340461at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8942" checksum="56197985E40F228F" modified="2014-09-03" version="1">MVTLTWRSKTLLSLIAFVSIFVFAASPPWDKFWLVLLFIFSLFLMFDVLFVTPRHFDFDPFYSNWEARQNDKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1D9</accession>
    <name>A0A061D1D9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0107510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766639.1">
        <property type="nucleotide sequence ID" value="XM_012911185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1D9"/>
    <dbReference type="GeneID" id="24562994"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107510"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="619"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="749" mass="84388" checksum="87AD2042A883603F" modified="2014-09-03" version="1">MEVSVDRVTGTPSCVVDPLSVSRIGFLCEGQIEPHDCMISLLDGDGGVVKPPRPRLYWKFVHHRPWVVAQYFDKLAVRPFYGECRCIDPQTSRLKARIEMRSKTDYVCDIASMIFRNRLRPIRGPWCSAVLHPGSTLTIKIPTQPVNSVSIDVDSDGDISEDVSNVPFSQLPSAYEYESEFLPKDLTTLRQRVKHYDFESYDERFYKEVLAGDAIELDLSQMSRGEIKLIYNANKPLALKYGTNSFCYYWKLASTNPNILDKIFAPVVVSFAYNHRYILRGCDRMQRGVFDPEISRKYCSIKLMGSGIGNIYECSLQVITDAANAGIYCGPDEELLPNNCNSVMYDLQSNSVVPYPAFIRKTSAHYFRGFQDLQFLFRSYVPISYACMCVDKRGYESSRLVLGSNNEVTHAYEVNRRTLFDTLLPYISLPWQKVVLLTEESNSSMMVDLHKPRMHSVELDVGTTLLLRCELVFDVPSPVNNEINLVTWLPTQVDEFHYSIHHTFHGSKLIRTSREAVMVSAKGGLQAVFRKYLEGAVYQTLKITSRRNAVIISKDPTNTKRVPLAFVCGKAPEQSSLSSVNGEGSTSGASGDANLQNTKLSDEHNWHVVVVNVETTDPYMQGCGVTYASDELFKPETPKLYDADGREIGCKIDLQAAKEAAFYCPVPYVLDPPNCFNNVFVDGIVKKVNNLSKSLEASRTNHFVTLAFKSKLVGRGETLRQTPPLECRCVTLKGVTLSTIQVENYYAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1E6</accession>
    <name>A0A061D1E6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Breast carcinoma amplified sequence 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0102650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766123.1">
        <property type="nucleotide sequence ID" value="XM_012910669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1E6"/>
    <dbReference type="STRING" id="5866.A0A061D1E6"/>
    <dbReference type="GeneID" id="24562478"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102650"/>
    <dbReference type="OMA" id="MNIHAIS"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25543" checksum="0215CF1246A0B482" modified="2014-09-03" version="1">MAASRSQSADAEAPLYRNNRYHGLVDSLAFVDAVPVELEGHIRELVDAEKRAILEEFGGDEQSLLESYIKPLGPAPDHSGSGHLYHAEVERRSRGEALQAIDVERYAGYEHVKDVEERLDHVHILSEYAQGAHLNLELMDRYKEAAWLSHLDNLVSMQSSMSREKSRLESAIEQLNKERKVSNVEWASRLRALSQEQEDYHARNLQLLAAIEKLQNSRQSSATEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1H0</accession>
    <name>A0A061D1H0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766153.1">
        <property type="nucleotide sequence ID" value="XM_012910699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1H0"/>
    <dbReference type="STRING" id="5866.A0A061D1H0"/>
    <dbReference type="GeneID" id="24562508"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102900"/>
    <dbReference type="OMA" id="HESTILN"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="711"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="949" mass="105100" checksum="E85E1FEAE3D6D7A2" modified="2014-09-03" version="1">MFHPRPFGGIAGIFAKSARSDPTSRSDGSAGHVPDGEAAVIDAPVPQRSVSLHRNVPSEDSVKGFQRLLEARRSIDEPRASADTKVFTELKLAADLKSFGERRPFTSSKPMAEHRRFPDFRQPPESKPLADIAALTEFLQSHTSVTVTPAASRSEPPKPQLKLEIPADAEQKAASEAIYDKLYLLHLMFNIQRISTEQGISVVDSAAPKLKFLPSHSFTQHSAGARDTVHGHREGLMGLYAQTAQSLFDQGEGGPKSMHIASGQRRSYFDQRIPKGKESFLLGREGYDLSDYPKRGDLHDGDSHFTDGPPRWKTYESNPMRSESKFGFDRFKGSDGLGLLDGEPDFHLKGLEHFKPRASPFASSAGTSGLHGAAEMSMQSLLQEQSQQDRFDMSEHYPQFDGGQVDTDALLLGLERHTMHRPSADVHFNNSMMMSDPYSTVESADQKLLQYTALAASAAQAQPTGGRTSDSSPWPSSTASDMKTSIKADDVFSSPLLKSSSNSISFLERLLDKSFDNSDAALESSIAEATAQFQKSLQLSAEQHLHSQPRREVQTQLQSHLILQSHLQSELQAQMHGRHGHSHGSLNMHHKLKSHIPLKSQHHLRSHLPSKTQQLKSHQPSKLHQLKLQSHKLQPLKSQPPSKLQLPLKIQPPLKSHPQIKPPMGPKSQTPLPFQMQSPSSLHASLHLTMHPQLPLQLQPQPNQPIPKTIDLQWQYMDFHGLVHGPFSSKQMYTWYINNFFNPNLKMRYNQSMQWTPFRELYPVTSRAFVENPVGYSPETPSTTTQQQAPETPNVVVTAPTTENSEEPVAAEAEAPTNESPQISSHRWNKPDELKVDSLLDIMEKQKLQSAPKEAPKAAASPDVPKPSPGWKVADSVAEPSPVASEDFPSLALGVEKATKPRKKLTGTPSQQGSTMTLKAFMKHQAQAPDNSRVQPRESFASKLMGNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Z4</accession>
    <name>A0A061D1Z4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766972.1">
        <property type="nucleotide sequence ID" value="XM_012911518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Z4"/>
    <dbReference type="GeneID" id="24563327"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110830"/>
    <dbReference type="OMA" id="WHRNENC"/>
    <dbReference type="OrthoDB" id="366086at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="984" mass="107504" checksum="77EC7A377A0EAF29" modified="2014-09-03" version="1">MILGSRSSAGISAAKAFSSATAAESSTQARGHVSVLHALVEAKSRADLLRVATRWEDASGRGGYNVLEPGGSPEQTAGNSRWPCTEGSNAPALNGFHAHRGRLWHRNENCTLHDNSLFKAAVCNVIRQGCSDVTVWSMLDKHISQLTNSRWELDFNTAHQILHGLCQFRCHDHILKSKVERIAAGLLDKVAAAAKRELRRGVIDLKLEPQRHIGSLDNIIDGRGDESSHAVWYADSPSSGLDLDCVWKLWHLLNTSSTICNREVAQLLMEVMESRKQELCSFDFLRTLCTMSVILKHGDRLAKVEEKLLLKLFKRLLMLLNHRSDGEFKDITSSKRINDDSYAADCNADATERPLAYDHEEEPTSIEHPQLQSSTEVKDVASPLTQHGALSKQGNVYLTLGHVRSFFEMLSCMCDKMPVSSFASTLASSGCVAGLSRLLEAASVLVVRSTALKKRLCSASVTSGPAGPSAIARGIEDCPDDFKAVEVSHMKILNSAVAFVKHVDRISCMDGHHSTHLFPIRGHMLKFVSAFFDDISCAKIDHNVAQLKAGYYMVLSAAANGQCSDDHVMTLSKWSLAMLQRISESTLPPTQLRHLIHLMVQMDKFVSLLKDLGVAVRLMPEQARVTKNVLNRFLTSDAIVLGDGSVRIGGRVRALSLLQKHGMLSTSQLSAFLKTLQNNSNTVEWQPHDIACLCELVREHVNEGVRHIPVPGCVSFVIRERVDGAALSITTESRVDKCEATTEHSVVLALLVPALARVLPVVVRNLNHDQLLSVLRSHVALGGVLDLCVTGDVCGRCASMNLRQCVDCLSLRCESLDEMALQRISYLLASRHTVLDITPLLNMLCATATASVSDGDAAHVAMCIKRHREDASVTIRGASVLNRTCCTTKLRHSTAQRLELALSLADRHLVVLDDASMLQRRIGKHMQRIAHCVHQAGGQRAASTVDAPVIAARSAVLDYAACFGGSTAHRNGKLHSALLNADQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D214</accession>
    <name>A0A061D214_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0104710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766348.1">
        <property type="nucleotide sequence ID" value="XM_012910894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D214"/>
    <dbReference type="GeneID" id="24562703"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104710"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="828"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="958" mass="108542" checksum="2A30CFBD7C08AA79" modified="2014-09-03" version="1">MAQCMRVQLAICAIVLQLIGFIGAVEYGFINNMSSLGANPLVVYHINMDEIGIATLTCPRQVNGTEYVWNPQPTADHDVSLKTYVIEDGKFHFVPFSKVVVTEAPRPYVRKVSKESQTDLHIDLMDDDIYAITEERLVFICGPRDLVLTDALQGQLARLPEIYETDIYSWDSTTPLIEEIAKIGISLGVIFLHRGLNHQLLQGCGSRPSKLFARDNDVTVDPITGTRSCVVDPMSTLRTGFVCKGRIEPNDCMKYLLYEDRVVTAPRPYSYRYFNTHKPWVVARYFNDVALPRFNGECRCIDPKTGHVKARMEIRWKTEYVCDIASMIVRNRLKPISGPWCSVMLHPGATLTIKLPKQTDKSAATGEEYEEDVDDIDYDPSTVPFSQLPSTHAYESEFKPDTELTLRQIQTIYDINDYDEIVTNKAFTGDVLEVDISQMERGEVKLKYHTGRPLALRSGYNSFLYHWTFISRNEYVLEKIRAVVNVSFAPTYRYNIIGCDRWRPGMFDPANDVGSLTIRNMRNGIGKIAEWLLDVMSGEEQAGIQCQPNEELFPNNCESTGYDLSSNQVAPFPTSVRNVTLYPVRGFQVFEMSFQNVPVSHACSCVDEHGYETSRLILRSNRREEYEYTVSREEANQRLLPYSLLPWTEVAFLHGDRTPMQSIKLHNTPHRPMKLHSGTVLSMRCVMYHALYNGENNAAAMPTWLPDYPGFNHYKIYTTAEGDRLIKRPHDESIAGTRRGFQVTLSEYTEEYSDLLIKSNSGSILVSRDPDHSEYVPMTFVCGKEISESDFDQSNDNAAAAAIPPPVALLEEYTWNVVQIDVEMTDPYMQGCGITDSRDTLFKPETPKLYSSIIRHPRGCKIDIQTAGEAAFYCPAPYVLDPPNCFDQVSVNGEVKNLSDISQSLVASRTKHFVTLRFDSELIGPGEKLRQTPPLECRCVTVKGIVLSTIQIGNYYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2K7</accession>
    <name>A0A061D2K7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenylate kinase 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0111260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767014.1">
        <property type="nucleotide sequence ID" value="XM_012911560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2K7"/>
    <dbReference type="STRING" id="5866.A0A061D2K7"/>
    <dbReference type="GeneID" id="24563369"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111260"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595704" evidence="6">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="269" mass="30348" checksum="0C942AA660D1BE14" modified="2014-09-03" version="1">MNSCRFNFRHLVLSAVSVCLATMSGLSAYDTETLLQEVRRRYNCLRKPEGNFIFMGAPGSGKGTQALSLRDTHCYCHLSTGDILRSAVRSGDPVGLQAKEFMDKGMLVPDNIVIKLIEGRINSFECRRGFILDGFPRTEGQAEGLKSMLSQIGKKLNSVLLLECPDDEIERRISGRLVHLPSGRVYHKTNKPPKVPMMDDITNEPLTQRKDDTPEIIRTRLEAYYKQTAPLISYYDKLGLLRRVNANRREEDVKADIDSIVEKTGSKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2L5</accession>
    <name>A0A061D2L5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Symplekin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767207.1">
        <property type="nucleotide sequence ID" value="XM_012911753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2L5"/>
    <dbReference type="STRING" id="5866.A0A061D2L5"/>
    <dbReference type="GeneID" id="24563562"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201780"/>
    <dbReference type="OMA" id="NINFVFG"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin C-terminal" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1255" mass="138780" checksum="59C3D106E582869D" modified="2014-09-03" version="1">MSQEAEILNLLRLGRRDAFEARLQQFRRLQSRAGKGKLCRLINHVVHSDGQYATVLIEDISNLLNDADTLVRIDALAAFASSAHLFMFHVLLARAVHPSSQTARDAVADLACALSLVRRAAVDMDASDCRGKNGLASVADLVHSGTRSPVANAIRVVMMELAILAQLGVAPGKSARPSPGPATSEAKESDVPQPELPQEAGATHRNYVEANGRPNRRYDSDDWRCIVRDDAELMAQITPWSASATRLLVGCICAATRSNKPGTLERSLIAAESISTLVSHYPHQYFHALVPALIATHTHLFRTVGAYESMILRVFTSQEAQPFHPQLVAMLNAAGYKCELAEMYKRAHITASGNKCYAADAEAGVREDDAVNFVAMIAESGDAEARFQLATKKLENRLDDEVLKGYKAAQVFECSALAVKNMTTADNVFNCANAQLRVGPPMLPADEPALELDCTPNPKYTMPASVAQIRPTPCEAIREHHKLYSLLLATQMMDTAVSYTWHLRAAVALGNRRDRFDFFNRALLNRLFMSVTLPKETQRNLLDALLDHMAQMVMINSKLGGPVQERQGGRQKAATLESSLADARNMGVKELMTHVASSHQSALLEQLLDSVSQLLLTKACIELAKGVVRGTKDEVIRELNEANSGDAAGQPTGGEIQESAAAGRLGYGELVEIVISKLYVPWILEVVEIRDAYVLQICKFLLNMPFIPLSLVNQISEWLLDPTSRRLAFSLISNILKKSQCTDLKQRVLELFLRSIVSEDGEIRGLFLKLVSSPKGLYRVNAEGRRYSVFATEAAHDALVAWARSGGGCAKCGVGPYLSKEVIEECDELAGRPVWQWTKGLITEIAGAHKSAGTLTSTKCKGCEWQELYDEVNKAPEVDTQLAIEWSLLPSVWLEELFALMAMPDALRAHPFLVDLIGAVGLEERDVDTMEPVIVAAGKNAALVPFICQISDKFDEDTTAKAGRNCCAHVAEITRVLRHEPQMNAFLVTLLGEVRAMWLDPKYNLVESWQRESSPTKRLVEVALGHLETCEEYVLQLTPFLGVEQLEAVVTHLFTKSTEEKLQRCLSLLLEVPATFRKEQKELNLALPQHFMYHCYGMKPNKELLKRQTGLLDLCVECCVNGQMSVESALSACTLIVESPEDVSFVFGRVLCQLVQKVPQTRSVVVQAILPALFKRRAWEDKMLWRGVVICMTSLWPGHKEQLCRLILLLPQQQGEATIKTLQTQHNIVAFMESTLPQLDQTVHIPAYIKTMLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2N9</accession>
    <name>A0A061D2N9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767054.1">
        <property type="nucleotide sequence ID" value="XM_012911600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2N9"/>
    <dbReference type="GeneID" id="24563409"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200250"/>
    <dbReference type="OMA" id="LDECYTI"/>
    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23546" checksum="B3A14D37F1FBC984" modified="2014-09-03" version="1">MGDRRPRHRHKDAKVELDTLTRQILHEITDVFALNCIKPWQADEAQAHSIGTIKAQDFVNVARQLGCVFTAAEDRAIRRQLAKHKIEYINVDQFVQLINNKIVQDHVDIQHEPATTPNQLIVPKLEELYDVLDWQKQDKLTTSDLKHFLAAPNNGEFDQKVLEVLLKHENIKFKRNINKEEFVKLFKPVEDTSYLSLKIVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2W0</accession>
    <name>A0A061D2W0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0202680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767297.1">
        <property type="nucleotide sequence ID" value="XM_012911843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2W0"/>
    <dbReference type="GeneID" id="24563652"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202680"/>
    <dbReference type="OrthoDB" id="361599at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="400" mass="45815" checksum="980AFC66ACE5B4A9" modified="2014-09-03" version="1">MRCVAPGSHCGSEVDPSLTACSTPTRRMSDSAWDEKWQAMVQHQRLRKEQDAQLHQKLKEKQELEEFIECTFTPKTHCTYKSRSSDELLKLMEPLITEEERILRELAKLNAEEQENIQLHSRALRAHIAANQGGEGDDLIRICERYREERLKEIARVKNRKLDIVGLLHEVERKYNIICVKEHLNEDDMLRACFSIDSCRLIKKEILDSVKGVDTLKDRSRVTSEIDAIIKRAKEDAQRQRSRPPNGPFMPAGAMPGYPVAPQWMQRPSNGLPYPTMQQPGPNLWYRPAFAKGHPPMNPQQQPMMKLNPAWMGMRPQQAQPFMRQPQTVAQTAKMQTQGAQQPAHIVPRPVFQAPQMRAQPGMMPHPGFVPGNPPLGLPPQMQHAQPQTLRRNVPKKVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D380</accession>
    <name>A0A061D380_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767392.1">
        <property type="nucleotide sequence ID" value="XM_012911938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D380"/>
    <dbReference type="GeneID" id="24563747"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203640"/>
    <dbReference type="OMA" id="AGMYNRR"/>
    <dbReference type="OrthoDB" id="439961at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="161" mass="18347" checksum="0F680B9AD5A59C6D" modified="2014-09-03" version="1">MAKGLRAKTLRRFRTAKRQIVAEAVEVPRLREANKKVRLLQRGIDVTPKLKPNKFLEPDNPEAVIPQRVVQPAIDLRSEAVPLSGLAGMYNRRKFTPEEVRESHFLSVVQKHLLPEKGEIAMDMDEVPQAVSSTAREGNYRRGKAHAHAMKKLNALKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D397</accession>
    <name>A0A061D397_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0108600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766748.1">
        <property type="nucleotide sequence ID" value="XM_012911294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D397"/>
    <dbReference type="STRING" id="5866.A0A061D397"/>
    <dbReference type="GeneID" id="24563103"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108600"/>
    <dbReference type="OMA" id="DYYVHFL"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="14">
        <location>
            <begin position="164"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="445" mass="51310" checksum="F8A162AA810DBE49" modified="2014-09-03" version="1">MKTAGPITRGGSVDAAVGQAPQKAMGSPGAGPQAKSHQKSREKSTVIAKAREHYTSQFPTAFPMESELWGFDRSREQWRRCTVVHARSRFPDRNVAELGPKDYDYYIHWLGSDRRLDCWLDVSDVRTIEEGPEPGQDVCHDVEVEAHDHAGMDEEYLREHEMNTKLKTIQRIKLGPYLVDAWYFSPYPKPYQNLDTLYICEFCLLFFVHESELQWHTKRCELRHPPGNEIYRDGNLAMFEVDGALSSVYCENLCYLAKLFLDHKSLRHTVNLFIFYVMTEFDDNGYHITGYFSKEKHSTNNVSCILSLPQHQRKGYGKFLTAFSYLLSRKEGRTGTPERPLSDLGRASYMSYWSEVLLEILFDPKLENVSIHTLSQMTCFEPADIIMCLEELGLLHTLSNGTSVITLLPEKKNELMSKARTKTRKLYMEKLHWIPYDAHNEATPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D419</accession>
    <name>A0A061D419_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767672.1">
        <property type="nucleotide sequence ID" value="XM_012912218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D419"/>
    <dbReference type="GeneID" id="24564027"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206440"/>
    <dbReference type="OMA" id="YSMKETR"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595763" evidence="1">
        <location>
            <begin position="31"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="215" mass="23788" checksum="A711F24B82A53AE1" modified="2014-09-03" version="1">MDFTRQYIYYLMLLCALTVSLFTYATPTEAEGVQPSKPDSGSFWRGKYSRIRASPGLDRMSILFGGHMCTIPENAILTETPPVIVVHGRLSSLTAVLVGYGQNEASGTFRSNKGYIYGVGYAGSYFPKFANRVSFTYDYRPPMHPRWEAEEFCALIFSPALKPGPTIISTVGNASNSPARYIGSTETIVKLLINESVGTKSKLVTQCCFLMRRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D442</accession>
    <name>A0A061D442_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0111000</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Sodium-independent facilitative hexose transporter. Can transport D-glucose and D-fructose. Can transport D-mannose, D-galactose, D-xylose and D-glucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766988.1">
        <property type="nucleotide sequence ID" value="XM_012911534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D442"/>
    <dbReference type="STRING" id="5866.A0A061D442"/>
    <dbReference type="GeneID" id="24563343"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111000"/>
    <dbReference type="OMA" id="VTCVLVY"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595434" description="Hexose transporter 1" evidence="16">
        <location>
            <begin position="21"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="17">
        <location>
            <begin position="8"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR94802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="472" mass="50861" checksum="FD33AE3F44B65095" modified="2014-09-03" version="1">MKPYFACSVTLAAIVAFNFGLNTVNFNASKEFATVDFGWCKGEGNANEYECTKATLYGSLIGGGSFIGGILGSLLIGVISKYGRRRAMIIIHAINIVGSLISTAAQCFSMLLLGRLIAGVSVGMSGMIAIYLTEICTVENRGTYGTAYPMFITMGQLLMSAWQLLHMRVLGATENAAGADAITMMDRFVWRMAQFWPAVFSMIALAIIYVVVKHDTPHVLLQEGKEDEAKEVIELLHGSEKADTVFAEVRGDVEALQSASTSLGIIAALKVPKYRRAIFIICGLSIMQQLSGINVFVANASKLFVSIMGRSFTASAMSLAGVAALFVTTLFLAFVIDKFGRKTLFLFGIAVSCVSMVPAVIIKMSSAEKWASYVMVVGCIGFMIGFAIGFGGIMWLYFAEALGTEYKDAAFGVATSVNWLFAAIVVISSDPLLAWNDKVAYSLYTGFGLLGFAFVYFFLKETKGMPLGQAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D460</accession>
    <name>A0A061D460_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 207, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0111250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767013.1">
        <property type="nucleotide sequence ID" value="XM_012911559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D460"/>
    <dbReference type="STRING" id="5866.A0A061D460"/>
    <dbReference type="GeneID" id="24563368"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111250"/>
    <dbReference type="OMA" id="KMGDIDT"/>
    <dbReference type="OrthoDB" id="365530at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="445" mass="47700" checksum="BFFB17DA0A57063F" modified="2014-09-03" version="1">MGRKSRKRRMLKPFCYFCNREFDDEKVLIMHQKAKHFKCGECNRKLETANGLSVHMQQVHKVVQRKVPFALEGRDNISSIVQGMQGVPFDAIEEHQLKHQKKMGDIDTCKQQRISWAVVMTAPTPEQFLAQLSMGNVYFPGFTAPHETYIPPKPYLLGQNPYATPIPPAPPYGHDGQPRRHGGPGGTHHAGGADDRRGRRLSTGVGAGSYQPHDEIARQKGFAPSGTGPLILGPTGMPIEAPSSGGFSDARGGSRPMVARSLSIGTGAMGFTPAPKGFSDGPAAAAVHTAARAEPSDAHGFRKVGGFSDAPAGPTNPAGFSEAQGPSRPQQELHKQSPGFSDAPQPPASAVAAESSSPTLPEVSPRPPQVDDHDTYMALESSEVEVAAPADNAMAVDTQIYRASGVAPLFIPPPTLVNTKLLHEADMESIEEMRAARLYGWQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4D7</accession>
    <name>A0A061D4D7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0207560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767787.1">
        <property type="nucleotide sequence ID" value="XM_012912333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4D7"/>
    <dbReference type="STRING" id="5866.A0A061D4D7"/>
    <dbReference type="GeneID" id="24564142"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207560"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="544" mass="59433" checksum="0AD5EF6B4497E301" modified="2014-09-03" version="1">MSLGILGERITGKEVRSRNVLAVQAIANVLRSSLGPKGLDKMLVDDVGDVTISNDGATILKQLEVQHPAAKMLVDLSDLQDQEVGDGTTSVVLLAVELLRRANDLANMGIHATSIIAGYKMAIRECVKYIKEHLSKRMSDLGEDVVVNIARTTLSSKMLRVNLDYFSEMVVKAIKAVETADEAGNRRFPVDAINILKTHGKSTRDSYLVNGYALMMGRAAQGMPIDISGAKIAFLDFAIKHYRLHFGVQVQITDPVELEQIRLKEKNVTKERIAKILASGANVVLTSQGIDDMSLKYFLEAGVMAYRRVPKKDLRRIARLTGGKVVLTMSTFEGDEAFPEDSLGRCDKVYEERVGDVDFSFFEGCSTSRAATIILRGANDFMVDEAERSVHDALCATSRALEQDSLVPGGGCVETALSLHLERFARTLGSREQMAMAEFAESLLVIPKTLALNAALDATELVAKLRAFHAKAQAEGPISPEDADYRWYGISLADGELRNNLSAGVLEATVSKIKSIKFATEAAVTILRIDDLVTLEPEKEPVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4G3</accession>
    <name>A0A061D4G3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0101480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766005.1">
        <property type="nucleotide sequence ID" value="XM_012910551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4G3"/>
    <dbReference type="STRING" id="5866.A0A061D4G3"/>
    <dbReference type="GeneID" id="24562360"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101480"/>
    <dbReference type="OMA" id="PYRPTGF"/>
    <dbReference type="OrthoDB" id="118154at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03572">
        <property type="entry name" value="ENTH_like_Tepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035802">
        <property type="entry name" value="ENTH/VHS_tepsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039273">
        <property type="entry name" value="TEPSIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21514">
        <property type="entry name" value="AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21514:SF0">
        <property type="entry name" value="AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="66811" checksum="4359850B098696C4" modified="2014-09-03" version="1">MAQQEVLSASQRNLLSRATSATSEPTPGYVYKDITDMVLRDPAILPTVEDYLLQKLARNEPYIKFKCLKLLKNLCARLPHEFNRNKVCHCHAVIEARTYKAPYSEHNGDYLCQMVRNEVEDLLKVIYGQQNASAAGGVPPSIPPQNRMIGFGNMPMSQSSANNQFGSTNPANQNYSLPNTYSVGYGNQGGIASTGFGNTAYGNQGGIASSGVGNMGFGNTAVGSPAYGNAGAGRKMEGFGNFKSKTPVNKSTSNQAFKVISDVANRFIPTSIMDKIERVSSAFTSTTLDQIERHVTSAFDKRKSTMQEPYAGSFANTHRPVPAFVQPSFNTQPERTLLPSLIPDAHAQHSTVEDVSGEIESKLVKDILTFSGIKVSPSQQIIDDFLMQLKDANVRYVVDELLRSINNRANRWQLQLRILCIFEALIVRANMADDVISHLATELQPILVKCREESQLKNKAYRVMQLLNSAANVPPRDVNLISTTSPTERKSPTAGEGVNTSSASELDLFASDVVKADDNNQNEPLRSIPSDFTNPAFDLLDSFTPVSSIRTPQESQASNAPKTTIADDILDFENLAISTAKNRTSTPEHDLFAALDTVAFQPQARGTNDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4G5</accession>
    <name>A0A061D4G5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein mdtL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0207760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767807.1">
        <property type="nucleotide sequence ID" value="XM_012912353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4G5"/>
    <dbReference type="GeneID" id="24564162"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207760"/>
    <dbReference type="OMA" id="DKDKPFW"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="461" mass="50324" checksum="336756B8224B5963" modified="2014-09-03" version="1">MVEEQAYSVTTDTITYVEYTALGKALYSMVSFVEGYDQHMLGMCMRAFELTLGLSQAQLSMMVTVSNMSRLGCCLIWGLLADKFKSNHVFSAGLLLMGMASIVLSSASQYISILFLRFIHGFAFACIYPVQQKIVAEEFSDPCSNLVFGIMQALNCIGSLLCAIITTRIAPKILLGYYGWRTSYLVLGYVWIIFGIAIVFGMTSEKCGNNGMCTAKPKTNMKEVIDGAFLAVFNCRTAGVSIFTLFVAETPMCAFSYMTIYLQYLGVSDTMAGVAVAATLIGGAVGSGVGGLIFKHIAEKYDRCGELCSGIAVLVIRLVVCVLFFVWRPPSGPLLWYHYVELSAFGGTLVTVGGVDRALLKKAIEEKCQGTAAAAIRTISGIASSLILFQVSAYLSEKVFGYVPSREPLETMQMAVKHRNAEALRQSMMYIILSGTILNVLCYITLICCLPSKKRQTSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4H3</accession>
    <name>A0A061D4H3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767664.1">
        <property type="nucleotide sequence ID" value="XM_012912210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4H3"/>
    <dbReference type="GeneID" id="24564019"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206360"/>
    <dbReference type="OMA" id="HLEVCAC"/>
    <dbReference type="OrthoDB" id="365359at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="97755" checksum="2C49D9A236D4BA44" modified="2014-09-03" version="1">MITRKAMCRRAWRGGCHASALATRRYSGLANSVSLEVARACSLWARREPRVVAGKNSAGSDIMLLAARHLGLPDSEQLWRLSPQSRQGRLPSVVSHTKIVYQDAVAGDRDGQHNDIWLGHARYRSYIALTMHGPSGVGGLDWWAGLGDKAATLEAGECVDSLMRSDATSGEGVNHAEGDPTSRTDTTIFVYPYSRKSSQLIVETLNKHRKGLTETDIRSLIYLCGSTGSSRALRFLGQLIREQCRGKETASAIHRVEEHAWPWMNHGSMDNVAQIGVPVVLDALASAAIIQYTFEKESAVFDYIGSQLQKLDAKIKEEGAAVADEVKALDEAVLSRVVNLLVLKRNLSQFNSDHIRVFSDFICDRLHRIDPRSVANIAFSLGHSKHLDEFWMFMMAKRIQDSPHEFGPDEVAAIMDAYSNACLEDHEFYATLCKQVADNFEHHNLQHLTVILRALARVRVRDEWLLENTLNRLQAHLKERENLSDDKGTGRELAYMTANCVVAAGDLGYVGNCNFDVMWRLLTTRIRDSSFDICAINWLPLAAMTFASRTTLQTFMPVWLRHVLHTIQKLRSKTFVLTIQRRHHLVRHVFRLGILPPQLLPRHAQSILDDICDREYVTGKVPEEYVPESSTFHLEVCACLRALDVAHQREINIVPFVMDIVVPPKVRNHANAQTYAHRKSTASSRHKYAKHTDCLTRSEAGIPTNSAPPGSDSSTHDTHPTTANASRKSTSTTKTMDEIESYRNRHHQAYLARKSADEKAQARETHSQRPAPAADCGITPPAQQPHQTVGYGEQPVVKGEIPQGYDYMDYEGDPMYESSVALARRLQEELNGPQPQRDEVRPPDSVYQERMISSENEDDDLQAAIAKSLIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4K6</accession>
    <name>A0A061D4K6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767168.1">
        <property type="nucleotide sequence ID" value="XM_012911714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4K6"/>
    <dbReference type="STRING" id="5866.A0A061D4K6"/>
    <dbReference type="GeneID" id="24563523"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201390"/>
    <dbReference type="OMA" id="DEANMIP"/>
    <dbReference type="OrthoDB" id="363951at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="536" mass="61566" checksum="5D1B7F289E179D6B" modified="2014-09-03" version="1">MHLPSALWRYWQAIWPAGFQATAHVNMGCATRPGRAAEEDVFSGTHWSEVLLETRGNGLFLFEPEVCVGAAARVPTMAWVLEHVRLELHPGKPYMTLPAGAAASDGGCGALLYFFEGRDEDSAFLAVHYPSMKDAEYACMRFRRCSLTYVRSLVDGCGDDDVSAGDVAHTIESLRHSREELAQQKDMLRLDNTLLYSQYTSNKQAFSESSAMQMQENAALRSQLERCMDRIQSLEGDSQARDGTIRALKEEREHLMDLTMRLQSELETSKEAVQASANSSEETLRQDFKSTLADVYRLRREVKNLRKDNARIANQFHSYKREVNLEYERVEELMYHSTIYEMLMHWILCNDLKVEYYETCHQMRPEEHQAFCERVHAAQEEFRVSVTLARASYINCRTHLFNELLSSISGHKLELPRSKRLLSLALERLDWIFQPESCRLDVREPIWMNQEKFDGLVEALLYKTSDHAWYNKLSYVSALKPILTNDGASDSMLLTLKRQLYESLNQNETLKRQVASMQKALGSKEHWQSILSRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4S5</accession>
    <name>A0A061D4S5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0208600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767892.1">
        <property type="nucleotide sequence ID" value="XM_012912438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4S5"/>
    <dbReference type="GeneID" id="24564247"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208600"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="806"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="936" mass="105835" checksum="D2E374C3590E259C" modified="2014-09-03" version="1">MCDFDGPDGLRSGNAIVSCHMDADIMNSVTVMCPRQVDGTEYVWHPQPNVEEQGHLKTYVSDDGAFSSVSISRVVHFESMNKFFWMQTTPSQTSMHVKLPKDELVVITQRRLIFICGPKDLVLTDTLQRHLHVLHELGQMESVPWIPTTPLTEEMLEIGKSLGVLLLTRDRRYLPLQGCGSRPSLLFAPNNVMVDSKTGIRSCVADPISPSLIGFVCEGRLEPNDCMKSLLDDDGAVVAAPKPHAYLNFQNYGHWIVSRYFGEVATRPFSGECRCIDPETGHVKARIEIRQKTDHVCDIASMIEGNKSHPKRGPWCSVVLHPGSTLTIKVPTQPSNPGSIDKEYAEGYGSDVGSGFHALPLSHLPSIYDYETGFMPKNLTTLRQQTDFYDLEAYDELSYDEALAGDALELDVSQLDRGEVKLKYHVDKPLTLRNGQNSFMFHWTSQPGNYYYTDTTRATVNVAFAFTHDYEMVGCDRSTPSVFDQYASRKYCSTKRMGNGIEDTYECSVNVVSDNKPAGIYCQPDEELLPNNCDSTGYDLYSNKIVTMHGSVENTTPYPITGFQALYFHALHDSPVSYACFCVDQRGYEKSRLVMSHNMLKSYFFTTEHINNVQMQRQISDAPIFSSRRSNEERMPLRSLIAEYITKKSVVLNLGTHLTMTCNPGLVYRDFENEPIVPSIWWPRQPDMYYYSVNRTARGLQLIRNRYSDSIASTPGGYSISFKPKLHKWREIFTIQTFRDSVLVSKDPKHRKYVSMIFVCGKELEQPHSSILTGNSYSYQRLRSLLYSSLYTWNVVEVNMETTDPYMQGCGVTYESDELFKPETPKLYDADGQPQFGCKIDIQAAKEAAFYCPAPYALDPPNCFNHVSVDGELKNLSDISQSLVDDSSNHFVILRFDSELIGPGETLRKTPPLECRCVTTKGIVLSTIQIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D522</accession>
    <name>A0A061D522_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766250.1">
        <property type="nucleotide sequence ID" value="XM_012910796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D522"/>
    <dbReference type="STRING" id="5866.A0A061D522"/>
    <dbReference type="GeneID" id="24562605"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103780"/>
    <dbReference type="OMA" id="YMREPLM"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="504"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="865" mass="93195" checksum="8FE01289017A6A88" modified="2014-09-03" version="1">MGVYRTLALCTVISNVAWSFEHRAHGGGAACFALYAGRRGARCSRRSPLSPDQRSRIAELERELASEMPADKPSPADELHFDRNLGSSYGARHLGRDAEILLDELMRDSDHCGDPPTSLGANKRDAIDVAEPKLNETGTRNGPSPQLRVVKERACKRGSRDSGLSKEERHKRTAANHAGRGIGSPEGPFHAASGAVEDALGSVDATARAASGAEPHDRTSVGDLSNSDSIENVLMESVRAAERWESDEHRFRNKVAEVPDNITDKEMLRMAELAEMEENQEGPTMRQLLKKLNEAPASKAPAAHWQGLVQRFDIDADTSHCVGCGIRLQSGSAAHPGFVEPAALSGVLEAKGRPRCQRCSSMRSGLIFRDPAIALGDSATAAARETVAIVRNALALSATRHVTVAYMMDALDIHFERGLADLIVARRGQRRAETHFYVVLNKVDLLPPHSRKRLIMYVHRFVQSRAPALRVKPRHIFLMSARTGDGVNLFLSVLLDEAYRKRSKVFFVGATNTGKSTFINRLSRFVDAEEGGDSGAGATPPKRQLLSTSVIPGTTLRPLRIDAGPGFNLFDTPGIVVPDAFTSHITSSELKIAVPASLGPAKPLRIGAGQSLLLGQFVRIDVLEGRPFFFTPYLSKHVNVVVKRTRNVGDFLAKLPFGDGRVFYATGSPAASSLMPGISWGSEARPGAAKNTSDNEAGVYNLATGSDTQWNPPSADGHPAAPTPEAEPNAEPAASKPPTDVDTCNHHTVNATGTLNAQGEIDTTTNYVRTFSDGGDAVGRGCKETPPTTSFEVSVIGEGWERATADLCIKGLGFVSLAGALELRLRVETLEGVSVYMREPLMAYDGIPFARKRLPTKAPKRRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Z7</accession>
    <name>A0A061D5Z7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0106430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766520.1">
        <property type="nucleotide sequence ID" value="XM_012911066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Z7"/>
    <dbReference type="STRING" id="5866.A0A061D5Z7"/>
    <dbReference type="GeneID" id="24562875"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106430"/>
    <dbReference type="OMA" id="RREHKIP"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="69"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="578"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="656" mass="74140" checksum="B586E418745D4CBB" modified="2014-09-03" version="1">MSDVADSYSDGLSEASDAEDDDLWLAQPPSNQEGLKQSNLFFVARQGDEKSLFRSNQIYKRNHYEKGLTKDKRTTVQQVLDKRTYIRLRKLCGQGVFHYMHGVISTGKEANVFEAETQPPSSSAISHNASSDVNEVVTVGQTVPCVCANHLVEAHVSAQSNGTGAATCHPGEGTNVNCDEVADKISACSIKETLQPKNTDESSRSTEKQTPGRVAIKVYKTSILVFKDRSRYIEGEFRFRRAYLGTKNPRKMVAQWAEKEFRNLRRIALSGLYSPIPIALKDHVLVMDLILDGSAVAPKVENLGALPLFEWQTIYVQTICALRTLFQECKLIHGDFSSFNLLYSNGKVYVIDTSQAVENDHLNAMPFLKRDCENVTRFFKNADVLHHEHEQMIPYDELKLLTAEQLFCFIISKVIEPIDDVIDEDNAKALPLSHDHELWQDDSLANVKCFWNINESEIALDVAQSVEKMTKYYKFGATKDIPEIMMNKRKMYLSLCKATYDFLTGPTFANEECYSHIAWLRNYNFDKQLPINISQMPLDVAESLMEQKENVIIGINAIVDKTSCESVEEACCYVDDKGEADSDESESDGTSDTEELAKQTNDVGGNNTDQRAKFTGKIPDGVEPREWKKMVKEYNRERRKSKIPKHIKKKYGSNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D606</accession>
    <name>A0A061D606_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0106530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766530.1">
        <property type="nucleotide sequence ID" value="XM_012911076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D606"/>
    <dbReference type="STRING" id="5866.A0A061D606"/>
    <dbReference type="GeneID" id="24562885"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106530"/>
    <dbReference type="OMA" id="PHMLEPI"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="314" mass="33922" checksum="18FE5C49BA12A553" modified="2014-09-03" version="1">MKLKIKTLNNLEAEVDVEADITVADLMKAVEAALPALPSDRQKLIHSGKVLKRELRLSDYSDIKDGDKVIVITSKQPPTVSTAPVVEQPVSPPEVQPSATAVSTEPLASASSRFVTGSELEMNISRICEMGFPRAEVEQAMAAAFNNPERAVEFLSTGNIPSPGDFLLNPGVDDHQPSNNAMHAASQDVSLQSIQSHPAFQQIRQALNSDPQMLQQLLENIGSTNPELLQNIVEHQDEFMNMLNSAGGADPLLSGDDGPAVVQLTEEDVAIVERLEGLGFPRPAVIEAFLACDKNEEMAANYLLENANDFASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D653</accession>
    <name>A0A061D653_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768224.1">
        <property type="nucleotide sequence ID" value="XM_012912770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D653"/>
    <dbReference type="GeneID" id="24564579"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211800"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="134" mass="15302" checksum="508DD7403D80F16A" modified="2014-09-03" version="1">MVQKEMEAKQKCECKYSENKNHHTKCGTRGKCICCPSCCALCKPLPGKKPCGVCQKIWQEHNCNVPKCDECPLYYKNGCENCKPKVGITAFCLTVLFLLLIVAVMYFFAWKSDPGFKQLRDYLNNGKDLSQFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D669</accession>
    <name>A0A061D669_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767698.1">
        <property type="nucleotide sequence ID" value="XM_012912244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D669"/>
    <dbReference type="GeneID" id="24564053"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206700"/>
    <dbReference type="OrthoDB" id="365268at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="239" mass="26555" checksum="E2FA88EB24AF46FE" modified="2014-09-03" version="1">MNFVRTHNYSSDKASGGHIDFTKGSLFSTDGAAPSTKGRQRERADKPDVDFKPKELFCDRDLEFTAENLTSATAIASAFSEEDIAHLDQLERRRNLLWKRRSLEEEEFIKEAQRLRSAQPDEETQESKKPKKDAEQGKERRHRISLFRTTRADTLTFEKGSYPAIQIAVVGTAPSNYTNEGKSVDNEDKEGHKSSSVSNLGITERSHASVSAKGGLVVPQKKSSSALALVSGYSSEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6B9</accession>
    <name>A0A061D6B9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767748.1">
        <property type="nucleotide sequence ID" value="XM_012912294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6B9"/>
    <dbReference type="GeneID" id="24564103"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207200"/>
    <dbReference type="OMA" id="DCEQFAT"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="199" mass="22288" checksum="E8C5360207466197" modified="2014-09-03" version="1">MAPDSDTLDSWDAYTDSEDEQQPEPPAPEDVAKLSEKLRAQKLSESADRDFVDDLFSVPGKGRGGGSEDAEADVFAQNPIHAIIPTDPLAHVSLKCLKDCDNVAKKLSQKIEQSQAKSAVWLQFIDTLFQACEKKIELKDLQTLKRKIEAAIKAKEAKQSQVTFSKKKPNDISSVKNYQDELDMLYGDLSDEDEPFYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6H3</accession>
    <name>A0A061D6H3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767803.1">
        <property type="nucleotide sequence ID" value="XM_012912349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6H3"/>
    <dbReference type="STRING" id="5866.A0A061D6H3"/>
    <dbReference type="GeneID" id="24564158"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207720"/>
    <dbReference type="OMA" id="ARLWKEC"/>
    <dbReference type="OrthoDB" id="366075at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="233" mass="25307" checksum="93FC81EC7C893BE2" modified="2014-09-03" version="1">MSSHGVTGFRLFYNEVVGDVRAELLARLGSETVPLADVQREVARLWKECPHQEEYRKKAAAIAPANGAADAQGKPEPGDIVIPPHRLKRILELDDEAPRMTKDASRTLGQATFAGHVDKHIVDTGASYPVKPEHIASVINNPLYPKYQFLAGSEEQLFNSTATHPKDRPSAASERAPTESEADKPNSELTESPGKLADNSESTLPERPVAPQQPVKARQPSILSYFGGGRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6K3</accession>
    <name>A0A061D6K3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766760.1">
        <property type="nucleotide sequence ID" value="XM_012911306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6K3"/>
    <dbReference type="GeneID" id="24563115"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108720"/>
    <dbReference type="OMA" id="CWWHFER"/>
    <dbReference type="OrthoDB" id="365048at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="930" mass="102894" checksum="4A5137A1033E7B34" modified="2014-09-03" version="1">MDPAALAQLLGATSFKVSDAAADDGSTRDGRWAALSESSCSSRSSSCDGFLPLPVDLGIPNDATAGAVKADKEYREPRCWWHFERHFDYLVDRNLRPVMDYALGRSPAHSNKHARSRTSGTPYMPQSHAAAYSGSNGTALQVSLANLVRSYKLLWKELFGGYECVDNERLSTLQCGVDRDFQQLMDYATSAESPWVGALVEEVAAAAAPFAPSTANIPGDSQMHMSTATAPTGSLFSDSSASAPLSAASPSDPAEPALPVSGTTAKRQARLPPRYQRSHNAAARNAQHCPGYKRKESEMVALLRKRGFDPFFVFLDQLLCGLEGCRLGARYAYATDLLTSLLRLMPELIFLLIGPRTGGGEGVRKRCYFKRLITLISCFLKYVWTERQFSLPEIYRDASCGGVTPFYLLTGEKELETRHAKSAMTATLLHRLFALTRLIGEKCMEWVLLSCDGGLPARAIGQRLKRFVYLPLLSIKQVHELVIPLIGQFTCVHTSLVDFDYMQWVRLYLFPPPPVYRLRAELVALLRLCIATTRLSLRGCCRRLNEELCANSVAQSAQDCDEELLRQVFLLVTGLSFFLAPEFLSTCVRNPEYFLGSYFILLPHAQCGLQRLSIDTFAEREVYPLQEEVLGLLKSAVDGDMLSRDDLLGLNDFSPVRSTILRRILALAWHYASAPFIRDDEHGVPLRPVVAPLGDAKHGGNTCSGWCRTMTPYSVQCSVDFLGHMALTPLRFRLRRVSMRPVKCIFTTADELEAKVRAGEEFINHSRVAANDYVYIRGGVSRSNPIEMVCESDDVTRGGGKDCDLTKAQGHDTAELQRSGTLPTKRCTLACMLRLHAPAADLHRVDDLRQSVLLQCAGTLTRYMNKHSDPKIPYANSAEAAFGPLSPIWRSLVELLCSTKLQGQMPVRAGSGACAKREVFLGHPVDRDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6L5</accession>
    <name>A0A061D6L5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab1b, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0302150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768497.1">
        <property type="nucleotide sequence ID" value="XM_012913043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6L5"/>
    <dbReference type="STRING" id="5866.A0A061D6L5"/>
    <dbReference type="GeneID" id="24564852"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302150"/>
    <dbReference type="OMA" id="YHESRID"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="234" mass="26084" checksum="65B9C201C6BDB0D7" modified="2014-09-03" version="1">MKEYDHLFKIIIIGDSGAGKSSLLLRFAVSPSTHRHIAMQDDTYSESYMSTIGVDFKIKTVKIDNATIKLQIWDTAGQERFRTITSTYYRGAHGIITVYDVTSRVSFESVKKTWLTDIEKYSNANITKILIGNKIDLEDQRAVTTDEAREFATQHNMDYIEASAKTAQNVEKAFESIARTLKDKATRCTTTAPTPNTFNLGSTTRVAANRNIVSDKCQEVPVLGPMAAPLNKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6U8</accession>
    <name>A0A061D6U8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766845.1">
        <property type="nucleotide sequence ID" value="XM_012911391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6U8"/>
    <dbReference type="GeneID" id="24563200"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109570"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="120" mass="13431" checksum="A20C392D1328FEA1" modified="2014-09-03" version="1">MRGCTSADCINCVMANQWGNNKYQCAPETCRVTISDAHWQMQQDDLLCVLSGLFCRLNVRAYFAFSFGTPALVPLKLTQPGTADLSQLFTFRLQSIKELSITFVIFLTVQSSLAYFTANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D747</accession>
    <name>A0A061D747_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWI/SNF COMPLEX-RELATED protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768534.1">
        <property type="nucleotide sequence ID" value="XM_012913080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D747"/>
    <dbReference type="STRING" id="5866.A0A061D747"/>
    <dbReference type="GeneID" id="24564889"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302520"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="1">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="226" mass="26149" checksum="AE7B641A46F244E6" modified="2014-09-03" version="1">MPLRRNCFVEFMRLEPKRDEREDAKCRISAPVQHWYDEKELNCIEREYVASILHDYCANTDDANSYYVDIRSKIIQLYNRDPARHLTSTDCIRCIDADPSTIAKVYCVLNYWGLINHGALRHLSSADEYLHQFKREIDTISHASSDADVGIARKEVDGASNVTPTENYLDCVDAINAPFTLERSLMDREISKKHLPQRTCQSCRSPCKYMYYMVETPADGMFTTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D779</accession>
    <name>A0A061D779_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768757.1">
        <property type="nucleotide sequence ID" value="XM_012913303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D779"/>
    <dbReference type="GeneID" id="24565112"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304740"/>
    <dbReference type="OMA" id="TRRCAQN"/>
    <dbReference type="OrthoDB" id="366256at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056320">
        <property type="entry name" value="Microp_apicomplexa_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23501">
        <property type="entry name" value="Microp_apicomplexa_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="103" mass="12074" checksum="19BFE06EC2E03E6D" modified="2014-09-03" version="1">MVDERRKRARDEDSDEEDPLSKNDPDRDFAEDLEPKRPRSTRRCAQNRKPITEEPTDSEAEEPEEEVAEAEDEEEEDAEEEYNSEDFQEEEEEAGDEEPLAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7C0</accession>
    <name>A0A061D7C0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768624.1">
        <property type="nucleotide sequence ID" value="XM_012913170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7C0"/>
    <dbReference type="STRING" id="5866.A0A061D7C0"/>
    <dbReference type="GeneID" id="24564979"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303420"/>
    <dbReference type="OMA" id="VKWYNEW"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="138" mass="15786" checksum="A7ED7AE7CC7086FE" modified="2014-09-03" version="1">MSGGGNSHDAAISGIPGHGTFKPDSAWQRALARNAGLYRYPHIDSDKNMTETQFEKLVREDDPKSACTPLLVQEFRCLNRNDFGSDAAHAATKCVKWYNEWMQCKWDEEKMRFGYSYLEDLPARKHKAYIAAPNYQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N5</accession>
    <name>A0A061D7N5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0211470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768188.1">
        <property type="nucleotide sequence ID" value="XM_012912734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7N5"/>
    <dbReference type="STRING" id="5866.A0A061D7N5"/>
    <dbReference type="GeneID" id="24564543"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211470"/>
    <dbReference type="OMA" id="YEFRLVT"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600124" description="Prohibitin" evidence="3">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="273" mass="30337" checksum="43374A90B5BB50C8" modified="2014-09-03" version="1">MERVLRRLAKLSILTGSVAVVPSTCLVDVDGGQRAVMFNRFAGGVSNTTLGEGSHFYLPWFQMPHIYDIRTKPKVINTTTGTRDLQMVSISLRLLYRPITENLPRIHQKLGPDYDDRVLPSISNEVLKAVVARYDAESLLTQRDKVSSDIRSAITARAKQFDIKLDDVAITHLSYGKDFSKAIEQKQVAQQESERVKFIVQKSEQEKLAAIVKAEGEAEAANLISRAIQTHGTGMLEIRKLEAAKEIAETLSTSKNIAYVPNTTNILLNATNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R8</accession>
    <name>A0A061D7R8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768223.1">
        <property type="nucleotide sequence ID" value="XM_012912769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7R8"/>
    <dbReference type="GeneID" id="24564578"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211790"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="8172" checksum="C5A717B6166B37B1" modified="2014-09-03" version="1">MLVDLHPIPTLFAASISVALWSIEIDAHKRKQSHRMPNVDILRLSLLHAMYKQTQMKLYSLMQLIFAPIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D893</accession>
    <name>A0A061D893_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768934.1">
        <property type="nucleotide sequence ID" value="XM_012913480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D893"/>
    <dbReference type="STRING" id="5866.A0A061D893"/>
    <dbReference type="GeneID" id="24565289"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306520"/>
    <dbReference type="OMA" id="NIMFRNP"/>
    <dbReference type="OrthoDB" id="5794026at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="469" mass="52752" checksum="B80024413D50E2E4" modified="2014-09-03" version="1">MQQNTATAGCKAQLKEPCYSTQRRDASSRTSTLDSESYFYDSCPGGDMYPSGMKRIRRLSAGSKLSAYYYIGSELRVCADCNKKSTSRPVLRDIIDRRTGEPKVLKIISKSRLPPGPDGLVNWRMLCEKLLNFEPCANIMRVEQVWESETSFYVVTEKLVGGELFEFLLKEKVIPEDICKYIMKQIIQAVELLHNRNMLHRDIKPENIMFRNPTNSALPVPERYELVLIDFDTCKMMDNANSENIEIVNGKRRLVGTYGYLAPEILRGEEYSTASDMWSIGIVLYILMTGVPPVSMEKMYDAKSSHAVLTAAETNGIDFNMPPLIEFPLARDLCRRLLSFDRNKRIASATDALAHPWLVGLTSIFDRRLKIKNYSMGGNSQDRRHGPADSAPGGHIRALFGKSSAKGGNHETSSSSTKAEGTRKMPLLECDTAAESPRSKKRACMLYSVAVKSTVIQKHPSIKRSCFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8A5</accession>
    <name>A0A061D8A5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768398.1">
        <property type="nucleotide sequence ID" value="XM_012912944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8A5"/>
    <dbReference type="GeneID" id="24564753"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="55" mass="6263" checksum="5B9BF380B567AEA3" modified="2014-09-03" version="1">MSRLFHYEAVLMVPLNNSNFIHPTLIQQSCHLCILSHFLTQPIRLQAVDEPGDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D9</accession>
    <name>A0A061D8D9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0306870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Hydrogenosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768969.1">
        <property type="nucleotide sequence ID" value="XM_012913515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8D9"/>
    <dbReference type="STRING" id="5866.A0A061D8D9"/>
    <dbReference type="GeneID" id="24565324"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306870"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034492">
        <property type="term" value="C:hydrogenosome lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000006">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000277">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0377">Hydrogenosome</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00084108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="34332" checksum="5BEDBCA5D566B548" modified="2014-09-03" version="1">MVTRSIVRFLGNRAVYRRGPGRRTFSSGASVYVDKNTKIICQGLTGKQGSFHASECLKYYGTKFVGGVNPNKAGTMWRCNDDKHSLPVYATVSDAKKETGADATVIFVPPPRAAGSIVEAIEAEMPLIICITEGIPQHDMIKVKNMLKDPACKSTLIGPNCPGIIKPEECKIGIMPGHIHKRGSIGIVSRSGTLTYEAVTQTSSNGLGQSVCVGIGGDPFGGITFTDVLKKFVADPQTKGIMLIGEIGGSAEEDAAEWIKANPTDKPIVALIAGTCAPPGRRMGHAGAIVSGNTGTAVGKIKALQEAGVLVAETPALLGATMKQALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J0</accession>
    <name>A0A061D8J0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769212.1">
        <property type="nucleotide sequence ID" value="XM_012913758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J0"/>
    <dbReference type="STRING" id="5866.A0A061D8J0"/>
    <dbReference type="GeneID" id="24565567"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309290"/>
    <dbReference type="OMA" id="CLHTNLA"/>
    <dbReference type="OrthoDB" id="378649at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="690" mass="73901" checksum="A1FF5478922B99BE" modified="2014-09-03" version="1">MDNTSLEQVDVHSAVHQDRRYSVESLKESLHAELLSHIDLSVVFLLLLRGELFLYEPKSVKTLSSLLARWRGLGEQKACGGTPACEGTAATHVTTGDGAADNTDNRDNGDSGSFDLSWSPNINRILHRVRQRFHCPRRRGTSECSAMTLSESDYEYCSSCIGREAVGMLSMPPRCVCKVRQGSEHKYHRKRADTGGVPSTADHESSIVKNGNSITPDTAKGDIITGVNVGADIRQPGENHTEAMADGNGTDAATATVDDAGRDGEASAKPTGIDKGSASLVSAARRLVANAKLGGPATSNYDHSGCVTCSSGGTSAKVVAVISPFVVKGVKKPGKNSRRSIKRSSRSAGCGVGVELDYHGNVEMYTSHNFPLNSFFEADVSGKYSVHQPVVTDSGEAPNTVADAIFDVVEAILCPDTDAAPTFSKNANIVAHMLHQKLAETYAGESSPSHPDDAEPNGAGESGAMLGRASRELMDLSEQGAFTSDVESKLLKEQGDLVGKVGSLVPFPTTYWLTDPELVAQVSALEGGGAIMHLQREIDMHAHAYEREGVPESGIFVRRLILDNLAYICQRFALLHPVILTALYTMLVNSVLFSRFYDSDYGSEDAVRSSYISLSSTPNGQPAESRPKNRSSLEKALAIVNTPRVYGIGGSRSFVHIKCLHTNLAFELAEGCALGSLVFEALADRTSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8R1</accession>
    <name>A0A061D8R1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769287.1">
        <property type="nucleotide sequence ID" value="XM_012913833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8R1"/>
    <dbReference type="GeneID" id="24565642"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310040"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="84" mass="9360" checksum="D7999FA136F3D5E4" modified="2014-09-03" version="1">MEQEDEGDKDGYDDSGDDVDKRISTTITVTTPHIFLCALWTLMKIMIAVFFSEVFANFAFVFSSTRFTTPRTAIIRGANTVSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D910</accession>
    <name>A0A061D910_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L7Ae/L30e/S12e/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767560.1">
        <property type="nucleotide sequence ID" value="XM_012912106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D910"/>
    <dbReference type="GeneID" id="24563915"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205320"/>
    <dbReference type="OrthoDB" id="10442608at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600169" description="Ribosomal protein L7Ae/L30e/S12e/Gadd45 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13779" checksum="1C4AA146C8B7B9DF" modified="2014-09-03" version="1">MSKFACGVINLFRILNLGWVSVKADAHWGVNRATRAIENNIDVEAVILFKGNVCNNMIWHIPAACRLKGVPFVSIEKKVTLPHTIPVKNISVLAIKKTNVRMGCLSEAVRYNYDDMTVKYAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D938</accession>
    <name>A0A061D938_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769397.1">
        <property type="nucleotide sequence ID" value="XM_012913943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D938"/>
    <dbReference type="GeneID" id="24565752"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311140"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="98" mass="10610" checksum="97E3C830C228FE8C" modified="2014-09-03" version="1">MLGYEPLMEADEACCDKSAAVLRDEQWMVWLGDSDANTICEKRINQQHSRDVTDPASDGGHLAANVAPLGDHRCPSLRYLVNVRGLRGPGGEGEDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D947</accession>
    <name>A0A061D947_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769254.1">
        <property type="nucleotide sequence ID" value="XM_012913800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D947"/>
    <dbReference type="GeneID" id="24565609"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309710"/>
    <dbReference type="OrthoDB" id="10383819at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="141" mass="15756" checksum="25F5ED63E3B52BB2" modified="2014-09-03" version="1">MKTCASEDWKGKVDPLQTCLCNVDVHENHYSIEERRCDEDCGGCGFICACRCCKPRQRGIYGGLATGAVVVAVTIGIVIYYVVTHHIASLKAVGNYVSNKLWGPRKLRFIPRSELDLPKSTHIPESMDIDPYSFFPSKDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D976</accession>
    <name>A0A061D976_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769284.1">
        <property type="nucleotide sequence ID" value="XM_012913830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D976"/>
    <dbReference type="GeneID" id="24565639"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="464" mass="53447" checksum="B29FEB99CF8F9824" modified="2014-09-03" version="1">MVMLLRDLSPVIQLSIGRVHYLFPLPDINYLLLSAAQPPILHNMWMTVRRKITSKTQRNKLLQKKSSDDRKISEAIHGARDRIEKYEREAENRFKSELRTKEIIERIRKRNEKQMQAANELDKNLEKTTEDIWKTQLQQNVEHIENDVKNEDAKKRLQQKRSEQKKKLEQQNISVDPPTSTVAAIPSQPGSPAPGLTPQPTGGRNAHGRDYYELRGRDRGQGDYIILGGKAIEDQSYEQHEKERKQKAAEERKKLWDLETKREEDRLREAMQRGLLDDVMEEVFDNDEMIVDVKGVVDIDVEGTDVSGGGYTALFTIEQRPLVNAEDESHSIDSQVVGVDESQLVFPVDGEEVKEKIGDEEGGLDDDKAVVIDGTMVSDADHAIFRHYGEIVVDIGGNEVTEKCDKQKDEERRMQLLYQNHHNHAKSLDGQPVPDPTDLILRQQEVTNMRRAYKEEEKRQRMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A0</accession>
    <name>A0A061D9A0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768748.1">
        <property type="nucleotide sequence ID" value="XM_012913294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A0"/>
    <dbReference type="GeneID" id="24565103"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304650"/>
    <dbReference type="OrthoDB" id="365683at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="255" mass="28823" checksum="3EE029027F4A1461" modified="2014-09-03" version="1">MVVYDSLLEAPSNLKESFDWIVAVRRCSGIPILAKALYLVLLRGAANLPDVKNMKGGNVSNVLSDDADYDDWDFDDGANKIIKGSHLPRRGGLTKPTSWVDNVMIKLNLMDEKETEVKMNELYRHLSKASIRIQLILLNLINDSTYVESYGRDVTWDNSCAENPWECADIFISLLIPLCDDLNFIQSECNKRSNLDSKLNGTGQRSVGKMFASVGFNLKDFIPKGTCRDFLKYYEPLKTQLEFLDGIVCKYTVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C1</accession>
    <name>A0A061D9C1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Syntaxin binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767705.1">
        <property type="nucleotide sequence ID" value="XM_012912251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9C1"/>
    <dbReference type="STRING" id="5866.A0A061D9C1"/>
    <dbReference type="GeneID" id="24564060"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206770"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="594" mass="66620" checksum="AE56892D80974AB4" modified="2014-09-03" version="1">MSLKAAAKERLLWAIRQVVVPFGRVVMLVDQHSLRVVSACCTVSELLDEGVDLVELITKRRQPMKKKVAVYLLSEDMRSVEHFLEDFKPRSEKYKSAFLMFNCHLDDDLALRKIAEEVDTGRVLGCVELHLNFIAYEERVFHGNMGFTLLSLYPTHIGSIAKSIASRLASLCSVLGSMPQIRYQAVASGLPQLVAKATSELIMATADEVARKPGDVLLVLDRSIDPVPLHIHEYTYQAFVYDVLRIPCCSDPVEQRKDDVWEFDYVACTGKRENRGVMLSGQTDVLWTRFKHLHIQKVNEVISEEVEKFAGEAANGALNNAKNTREVLKAVRELPKTRYLVEKYYAHITLTERSFEQLEAKNLVKVGELEQDLATNVDRNGNKLSHTKALQQLNTLLEDVGIDDETKMRLILLYVSVYRNVTQTHVAELLTTARLSSLDATVVEKFVELGLGSVATPSGAAISPRSASSSKVSHRLHDKCDAHTYYKKHARGGEYELSRYMPDIMHVIGRVVSGTLEDDKFPRVQTDAADKQQSPRGGRVIVYIVGGITFSEMRTIYDMAEKMQADLYLGGDSILVPSNVLENMKHAFSAVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9H2</accession>
    <name>A0A061D9H2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0312140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769497.1">
        <property type="nucleotide sequence ID" value="XM_012914043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565852"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312140"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1952"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="1846"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1846"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2014" mass="223539" checksum="B01227B2FEA5FB1E" modified="2014-09-03" version="1">MMNGSTDNPIEQTNCSLHTWWHEEKLTDCPDNLRESIDWLIQVRYGNGEGGKGLTKLSQALKKLIEEAISNAFYSLCPDEKGTSTPPSTPSPSSGVSPSSPSSTGWTTKISDKIQELNKQKDELEKRKNANNGYLTEKDSKSLDSLPTQVASLETVQKLAEFADQLDTNKRNHNNILNNLCVGLETFLGFNSTSNGYDGSGIVYSDLDRLCDGVMGFLSGVLEAVKNENEVTTYDNNLQTNLQTVLKEVNKQIGSGRAGLAESVDAVKEWLEGYGEEVGKKTNAVTNSITTLSNNLIGGYTEIVKSKNVDNLKSQLEGWRDTVETISNEVSRINDERISELDDALKSRINNEMNVIVGAAKALKASSMDGTLQGQAIYVDEALKQQESDIRKKIQDGCEWLRKTMRAELFSMRKSVTVLEVRSINHIRDINDCLKKARESLDSALGNSGSTRNEIHNMFTKIKDSLKDVDPAKSRSKQSELRDQVQMIKLAVENVDDTMHKHVHEIYKWMKDTNKIIDDVKRTDLQSLFDEVDNPNKCERKKAIDDAAEQIEKKTGTFNEQFMAVKGRLDEEIAKVKGADGLTGPLKQLSELHNKINVPNDASEFQKDAWQLDSRALKNTLKSNVTNYIMGYVEKVRRKVGSIKGLSNDVGLQGMKKNVWQYAQKFSNKNDFTNTVLNDWIADILKHNAEVMRLLKKYVEDEKQSGTARNKLKSSNLEHLISGEDSALHKPIKDTITKHLQAYAYGGHELTFPGRTTQNIVGDLQAVRSICEAFAKSLNANIENGVGSVANDIVRAIDTPGTWGISSSDTFPNFYLNRAVEQTLVALSSAASEAANELGAILQKCNIGNVDVALQTTEDLLVDLHKALQRGAAAHVGASLHSVGKDAEIDDKLDDAIATEVERSEVQSQLGELLQNAVKKGIAVLNDRIQNEVVSKLNSVDGAVGNSILDASAARQAILGGAELVRTKLAELCRTIREAGKTVQLQFDHLKNDKIENELAEIKSSIASLRSTNVTRVTTNIQVVLTKIEELDKVPGAVDKCRDDAERLMHQLYNDLFDKLNTIGVTAAKADDSINEAIQAVLVTLETSLRTLDSDIETLKTQLIEQVTSSFAILTGGVRKLFTAERHADLRGLEMLVETQHLEIQKIIDNDKATGLKGMLKTLSGVPANFKGSVSDKNNLLSQLEKAVPKKDPPTKGDFTALVQHVRAYLTPLVVYNKDEIKRLLASPSPSADYSPQLKSIFDKLVELLNHLEKDKLYNYDHNFVNSLTSLNSLSGLSAFTEQLGHAYVNRYSGQKYTALTVTKTVKEPSKTGESGSKVTTKTVTDLTPEGRNCAKVCLTIVEMVSEDLKYLREQCDSKWSTSRICSSRSLGAFMQKCGYRVAIKDAEQNGELQNKGTMTGLEIHRKLVGDSHTYVYNKGKDTKNALENFHSYLNLYYDVCHIAASLSTRRPCSISEILIWLTSLRHNPVYFNLITDSFSDLFDKREKKKAAVADDDFIEVEDFTELSLAAYPQNLTPSDLHDAVMHVTSLAPVILTTIVGFGDEYTTYAVDYHSNAAGFAIPSSPSSCLSMLLELMRRLFPVFRFLHSRCSNLASEYGWYHCAYGSDVESAGWQCKDHSKTDVDCRPRSPLMSYLRDSLPGHLPHQLTSVDCKSECKTCPKSTPGMPCITPLGFKGFSGSKRTGKDISNVLTKFFDKGVASCLLSLSPRPPSSLPEHYAFALSFVKGWSHNGGNGLQDAINKSIKSVSMELRESPNEVTDALRNAYGDARGTHNTGRHPEPKNAAVSSLSISTRCRGANHCGPYLSTLYSDTYPYFGNKHCNAYMSWSVYLPWTFWQQLNSLYDAFLQIFCQDWGCTGCLRGDTCKKGAHGMLNPDVPGDGCKCQSIVGCKGVGPTLYQYGFTFQDVHCLISNETKCFNLRNQLCSVLNSQYFKDLFEKCDEFLWIIRQPFSYLVLTLWLLSVLYLIHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9J7</accession>
    <name>A0A061D9J7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0207540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767785.1">
        <property type="nucleotide sequence ID" value="XM_012912331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9J7"/>
    <dbReference type="STRING" id="5866.A0A061D9J7"/>
    <dbReference type="GeneID" id="24564140"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207540"/>
    <dbReference type="OMA" id="TIWESTW"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="169"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="401" mass="43178" checksum="B259A6DD7B8EC40F" modified="2014-09-03" version="1">METRVNYSLQSLLNSCQRYSVDVATCRVSTVDPKADATSGDGPASHPASNHGSSLTIRVAALPTEKQSATVKRRKYEGGFTIWESTWFLAAFLHEEMKTRSGGYAIDLGRPLRNVASLVSGCGNGICGIIGTQHRYKVLFQDLNWDVLEESVIPNCILNATSIYGTVSAGRGQKQGPRGQQAGSPPYRNSSAAVTRNEGATTEEGKNEGAARKAGPEKDDPPSTETDGGNGETDFGGKLDVEKGSNYHFGTFIGDSLHGTSVSKEAHAVPLTDDRRHELEFELIACCWEDMADLCTGVLAARKAACDIIFASECLYRTESYPAIAAVLRSFLRPAHGVAFIATKRFYFGLDGGTFEFITFINGTSEGAPPDLKASIRKSHTPHGSTNVIDIIEVRMTGDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q8</accession>
    <name>A0A061D9Q8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swt1-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769612.1">
        <property type="nucleotide sequence ID" value="XM_012914158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q8"/>
    <dbReference type="GeneID" id="24565967"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313280"/>
    <dbReference type="OMA" id="FWANQEI"/>
    <dbReference type="OrthoDB" id="365277at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041650">
        <property type="entry name" value="HEPN_Swt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18731">
        <property type="entry name" value="HEPN_Swt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swt1-like HEPN" evidence="2">
        <location>
            <begin position="548"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="910" mass="101094" checksum="07C01A4929FFB29F" modified="2014-09-03" version="1">MGSRVFQFVLCNETSIVIHRHSHSIKHGSWNTWLPERVFGGSEATISCSFSRAFSGVCLTLNYGAILNRERYLLHIKLERVGGDEVLSAVFAPEGECRQSPRSMSARLDSTCPVIFKVHHEILDCGSGGRFNKTFRVRVQETADGSLYIKGLKECIEELVLRRDDGLKCQVAQGGIEAFQVYESLPDDFTWSWSTSSWLHRLRKSNRSILIRIVNLSGKHMKLLLGDGGTALDDGHWVEYPAEDLPHLCCTEFGVRSTGFFGGTGGKCVYNILGESGTLNFSWEQPSIGSMVASGVHSKGKYSIAKHFEPFNEATLTYHIYDVVPPAIDLWAAKAISPNVPSKMLDVMSLPVDPRGYHTFDHITASQPATNSKFEHPPISVTNVLHLLLRYHEHGCDNAGDGVGFRTESIGGTEGDETANMGGCIGTDLFLKSPRHFFNSAILGKRRDMPTVSANCLLYLDWGIGNERFCKIFQPDERIHLRSSIPGGIKSKKLLFQSRMMYFRCDRPEVFRDASDAGTVSSARDRRARPFLQSLSQTELMEYVLTIFHSLCEGLQPYVTKHMVRKYGANWIDDVRMPVGHVWRSEDQVRIDIEGMVYIITAYWMEMFEDLFEGNSGTLHIIQTAAIYWANQELHRFDSDYVWDMLKATERLLHRLRADGPLSHIEFISHKMIAGVQLFLQRIFAAKDDVVDGLVRGISRGTGHDYGGKNGFVQEANRALADIGYMLVRVVFNGSPYYVLKDLESTSYGGAPGGPSTDNEGDMSPSHSSQTTTGRQPDSVRAFDCKFTSGEVSVYMDAMSHIVRESGCPASTSTSVAAGTPLPMADPSAGATSWKSLCSRHAISDSAAQQALADRFKRDGWLVVDPAHAALMPGVRFHVEFLENYDLSGHPDCVFCGGKIICMVSGDNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q9</accession>
    <name>A0A061D9Q9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0208080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767840.1">
        <property type="nucleotide sequence ID" value="XM_012912386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q9"/>
    <dbReference type="STRING" id="5866.A0A061D9Q9"/>
    <dbReference type="GeneID" id="24564195"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208080"/>
    <dbReference type="OMA" id="HFVNFQR"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="273"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="732" mass="82335" checksum="472F9D2C21B59EC0" modified="2014-09-03" version="1">MLKISSLYAIYLVCAAAKYATRGFSNTPTVLSRGSIRPSPAYRTEPYGRFGHTKAYLGARQANSETASTVRRRSSTLQTHRTTIPKMEASQLSELLKKNKTQCENLLKRRFFYTNSFEIYGGAAGLFDYGPPGCALKAQLEDLWRKHFIVFDEMLEVSCPCITPYSVLKASGHVDRFTDLMLTDLSNGECYRADKYLEDVIDCVISTLEGKNVTDNVNAKNVALMQLGREELQKLQNLVGNMTSEDVDALIQQYGIKSPQGNELSKPFPFNLMFQTTIGPKKDQKGGTNSVVYLRPETAQGIFVNFGRLLESNGGKMPFAAAQIGLGFRNEISPRNGLLRVREFLMAEVEYFVHPENKTHARFHEFKHVMLNLLPKETQERGEATLVSMTVEDAVNNKVIANEALGYFLARTRLFLEKCGIMGEGLRFRQHMSDEMAHYACDCWDAEILTSYGWIEVVGHADRMAYDLKAHSQAANVQLNASHRYPEPIVVEKVTPTYNKSLIGKTFKDKNAQLLRILDNLPQDEALQMEQELNTTGQTIVKGDGGLEFVVTRDMLSFKVVKSVVCEETFTPSVIEPSFGMGRLIFCILEHSYKIRQAQKDQEERTYLALKPILAPTKCCLLPLSSKEVFNPLISKIQRHMNDLGLSYKIDSTGASIGKRYARTDEIGIPFAITIDFQSVNDGTVTLRERDSMEQVRLESEQVGDVIADLIRGRTTWGDVTKAHPIFTQQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9R5</accession>
    <name>A0A061D9R5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769622.1">
        <property type="nucleotide sequence ID" value="XM_012914168.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D9R5"/>
    <dbReference type="GeneID" id="24565977"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313380"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="741"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1691" mass="187427" checksum="49C7DEBD83E0508A" modified="2014-09-03" version="1">MASGKGPEFKTLKECLEFLEWLYTNKQGQPLQSSIANRLYRLIKDRYIGVNQGNIEKALSTFLSRVSNFHKKLCKNARGHYLGNKSPKDVLYALLESIPKLLSAIYFLRYKVDANFKALGGGGWTENQVGYGKRMRSPIDAYITAKANERKYGVISGGFDEIELKMGHQSGYSQGSNMVNDLRMILDKHFSGYNYFLDVFATSVFGKHGSDMSNVANALRLVQDFCGIFEKVTGEEDFKNNLQARYHCISWQDLQQHCSKLKKSLEKIFKGNRFSFTGYAREPQVLSTENIAKKMAKWFKNHLGGVIEKLNDIQAFDTKRLPLNSRLFRNTAVLPPKYPEAFTAYFTKNFIPYGFTFYHNQYKVESTPYQVLFDNWNGAIHELKNTSDGLDELLKILNGKQCASRQKVKKTEKKPMTKPDAELESDTGHENKPKPDAETGTEPETEPELEDDNELEDDLDSEIDSDEELMNQPSDEEDASINESEATKTEAAKPVVTKNEATPNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGTTNQPGGQSDGNGSSAGTPSPGDPVPSSGQDLGGQGSASGRAQQSSQEPHTGTGDSTPIGGVNNREGPVSKDKSDEDVKREQRVRQYSERQEQRRKQAEQKMAAMLQRVTDEKKQNEEVIRKHQEADMERQRQWQQLQGSDVPLLTGILIEEPPDLVLDGEIVKNDNDARLQDQMNLLEYNNGSYENSLRVETQREIDELRRIMTRSEQLREAAEHEWKSEQQILSSYVTGKAIKNDNGISAGEFTSLFPDIGVPRVYTIKRPKAPNTSQQLHQPPAHTSPPMSKHGYQTGVGVNHKLSPISYIHPSPITANSDDIAMPGIAGVSITDTSLSSTIIDDLPISSQNDPSFQTMVGLKGNIIPNPKRRASLPPLPSLKPPDQVSNTPSKLTVNIPVDGQMIGKMLNVAGVAIKTPSSQLIGDSNLATSAIQEPKGQPIIHTILENLAPPYQTMRLTGKDVADPNIKDSRFPDIPNLISVRPAVSHSSNPTQDERDLNVPHVSGNAIEFPPDTLAAGNTPAVLADSDASVVEPMETYNPAEVPDLESKTLPETVAFDDHIMGNMTSFTGTVLTEPSKMKRKNMVSLPSPLMPYISGTTVKENYIDSPISPHSVEYLHPARPPPIDVEIVRPPAHQTNSNKLHTSTVTPKSRDLRFQLPEIIPLYRGSQSSQNSKIPDVELIPVPPPDDKLQISVQPKRENVDLTEQDIYGVDLSETFDVDVRKPAPPAIIVPDIPSQYSRALFAPDLRVEITKPSEPFQATVMDMDPFMDGSNVEVSQPTGKQNSDPTAADVYGKEQYDVDLQIHVPDRTIQDDSYDVNIDEPPPLQELQPLNPIDPATTAISLSIDPLDPPESLPNRYVDPYTHDAQSVSMCTAPWMTQAETGDSTDIPETELFPSRAPRTVRDMLQWLAGLRNEQHHNTLEKCIAKAFSGPHSDPSQLALSINHTNIRPKDVFDILQLTAMFTGSVLNSIAPKWKANVSSRTVKPKLSNQSDEPDCCALLCQLLDYVYACHHQLQFLKAQCKREKSHGGWQNYNYGNAVSPSDSPLQAFLTEGWDSAFDTHLFDPCNLCHKSRVRMGFKKEDLAKTSQQGNTLATILTPSCGGSDPLLTLCSYLNCLTRRTPRTTGELVSYFHNFGHSIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9R8</accession>
    <name>A0A061D9R8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RIBOSOME BIOGENESIS PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0311710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769454.1">
        <property type="nucleotide sequence ID" value="XM_012914000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9R8"/>
    <dbReference type="STRING" id="5866.A0A061D9R8"/>
    <dbReference type="GeneID" id="24565809"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311710"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="13">
        <location>
            <begin position="83"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="422"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="431"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118444" checksum="84654621DAA50378" modified="2014-09-03" version="1">MDGLAGAVPHQSHKRSNSRVKTEKKKKKDLERKGIKGKQARHNPKAFSFSGGRHAVHRRVQHASEVEEKRLRRPRVFKAAEVPPPFVVVVQGPAGVGKTTLIQSLVKHYAKRNVAAVKGPITLVSSKERRLTLIECGSSMVDMLDCCKVADLVLVMIDCSFGYEMETLEFLNIMQTHGFPRVVAVVTHMEGFPDNSVLRKAKKRLKNRFWAEIYDGAKMVYLNGLKYGRYKKNEIVNVARAIASQKPTTISWRQSHFYCVCLRHEVLGPTSSKDSGKVRGSSGKAVNGKGEEDGDDATVRVSFYGYVYGSRIVGKQALHIPGVGDFIPESVTNMQDPCPVQTEGRTLKDKNRNIYAPECDVGNVMLDDDAMYIQLARAKEHFTEIADEEPIQSEAVKMVRELQKSEDALKSQLRSYKFKPVGAADARADGDDGSGSDGDYGDDEDADEDEEGDYDVEDGYGDYASDDEDGDGDDDDDDDGDDEDYDDDDDDDDDGDDDDDDDDGRDMGSSISQKSASRTRSRRNDHEGSPDGDSSDSDGVGYNDIDGAFSSSEDESDSSVETEEEREALSNLTDEIATKVYGTESVTPTDLVFVDFSRLEDDKFDMEWNEEAMADLRSECFQNYTDEADVGADDSAAAAVAGNDPENEKLARIEEAEQKRLYNEALALSSVGNVGQFVRITVNGLPHDFLKHRDANRGRPIIIGGLQMGEQSSGYIQVKMRKHRWAPRVLKTNDPLLFSIGWRRFQSLPVYCMDERNNTRIKMLKYTPEHMHCLANLYGPLAPPSLGVVAIKDWSRVPHYRISATGVVVGTNQEFNIKKKLKVQGYPYKIMKNTAFIKDMFTSELEVIKCQGSRVVTASGIRGEIKKPVGKNGSFRATFEDKILMSDLVMLKAFVSVRTKRFFNPMVDWEAFRRVRTMAELRTESGINPDSVYEPKALLRRPTRRFNAIRIPKPILEKLPFSSRPKVYESDPSKETMGHSEYEASVAAMMQRLMTIRKSRLEKRKADQEKHKAKLMIEEEKRAEAAKERLKSVKKQRYMKRGMAEAAKRAKMCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9R9</accession>
    <name>A0A061D9R9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0313430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769627.1">
        <property type="nucleotide sequence ID" value="XM_012914173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9R9"/>
    <dbReference type="STRING" id="5866.A0A061D9R9"/>
    <dbReference type="GeneID" id="24565982"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313430"/>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="345" mass="37981" checksum="1EC96A8EB4826DCF" modified="2014-09-03" version="1">MLRIPYADDLHCHLRQGELMSLVTRRIRQGGCDRVLVMPNTTPPVTTCAQAGSYRQQLLAIEPRVDYLMTLYLTHDLSADDLRMNARLNNVQGVKCYPVGTTTNSQHGFRSLEEFYPIFSVMEELGLSLHVHGEQPGSSPLSAEAEFIPHVEHVARSFPRLKVVAEHVSTKASLDAVSRVPNLAASVTPHHLFLTTDDVLSELDGVTLDNIASHIKNPHLYCKPLAKSAADRDALLQAVKSRSAKIFLGSDSAPHTLAAKSSANPPAGIYTQPFLMNYVATIFKQLDRLDFLEAFACRNGAAFLGLPQKELNCFELGDDTFTVPPTVDDILVPFLSGHELLKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X6</accession>
    <name>A0A061D9X6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768958.1">
        <property type="nucleotide sequence ID" value="XM_012913504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X6"/>
    <dbReference type="STRING" id="5866.A0A061D9X6"/>
    <dbReference type="GeneID" id="24565313"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306760"/>
    <dbReference type="OMA" id="FSERGIM"/>
    <dbReference type="OrthoDB" id="361041at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1212" mass="138813" checksum="DDB54D5F41A5DC90" modified="2014-09-03" version="1">MTSHGGELQCRRDVNRLDEHSSPSDYLATAGKKGIRASIKGDQIASIDDIVGQPGAEDAAFTDTSFASSLTRESLNELQMQEDMSRCAKGANRTGQGMRRRSDIDERQQYTLLHYSVPQQLELLDELIRSLGQCYPRWKHRRFGLQRFYCHMFNIHMDPIARSNYVQLFCNIWDGFEKTGINSWSSGNIWLQLLTHEYQVHRAKPNDFIVQREYSNSKRVEEVLQQLDEISSCFCNERCAMDFMRHSSYWGPTAQTTVTHEEEPVKEPISACFANTDNLKKGLHTSKINTIASFYQERGIIHNFTRPYEHGVQVTPMPGFRRSVVCLSCGRVCWCSCERKLFRNYREEKEPEEPDHVSVATESGESQSENRDHEYEEVEKECREAEAPEEDEEEEQEEITDIHEFVNTLQNKKQSLHPNIAKTAITVSNARKVDSGIILCYHTNEAEEYMSEPASPSDLKQQLLRATVLRGSVEDIFDAIKPRMGDFQLPEHTHGIFEEWRKVPLYRSWRRCWWRLVGKGAMDTSDDAVRPFVQRALERLDALGNVRYNLECGYVAVGYLQKRSRTCSYWRHFYVRQHGLWRAFTKAAEYNLMICTLPLELQLDPKAMNWTVCKCHQGDMYRKSFSTVKRGLVLGYAMAISWYENLLQELNGVATSFSDFDEESDVGCDEFDEQHFLKRDPAIYEGVNTVERAFLSAKRRKMVLAGDRGFGSMGRSGSRADSDLVDPRIIASAKEKLMLDHNLWYADIQNLFPEVTPDGFVDPEPAKGMTLRNLVAQYSELKDYFTLSLKHVDECVYTLKMCVNNALTKGNMDLVEPILRLNDDKKLADVIPQVPMQWVSFQQANDSWTCVLECHACITCAPRACTKQNCTKFQNGKEVIELLRKKFGPCSVEFTRNPFQANEGESAEPAPEADECCVVGFSAQKFGFNGAKALATEFRKRFIQIVFSSMKYDGSFSDALLGMIAEEIGLLTSTDAYILPNKANEEQRQNLIESLTCGVCSTFGDRMQHRNGTVLLKQLVKSSVPGKRLSEVFALEQMAEAILLDFKLDIKFCPVHMAWVVWWLDCMQQKRVMFYRVEDLISVNSLEEALAELEKHWMDAVSAHVEYTVGHAAERCQLTITYRFEEAFHHLTGLQKNLYDAFHTAFAMALRAITDSRQEFKLIKRLWQINKNEPEDLVAQDVNAQSFALTETVVFPFGALHDEGTPPLSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA13</accession>
    <name>A0A061DA13_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UFSP1/2/DUB catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0312610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769544.1">
        <property type="nucleotide sequence ID" value="XM_012914090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA13"/>
    <dbReference type="STRING" id="5866.A0A061DA13"/>
    <dbReference type="GeneID" id="24565899"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312610"/>
    <dbReference type="OMA" id="KGGIGWK"/>
    <dbReference type="OrthoDB" id="417506at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF2">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="4">
        <location>
            <begin position="549"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="768" mass="83940" checksum="D4481E647587CB1F" modified="2014-09-03" version="1">MAVSVSLGLFKGLPVNEEGHAHRKIARCLFAFKDETNGPKWICSYRNITVGAKELASAHTVPNYLQPCGVLTTGVNSDEELKELLPNNMLGQELHVFKWNPKKEDNPSLQEAVQCFIMTIQNEKCEMKEVLSADITWIEDDMAEIGRRGYTPIATSLLANVPLHTSEDVELSMELLGLKKMEILPQALRNAATSFLKDQLVQFINVENEGLSMDLTDIPMSKGLANGSEPSYAHLTFGATKEYKKHALIYTVPREEEAEDESIAELQVVLQTTCVAPTDIVGDEPTEELAEVTLEALRHIATLSFGSESLLNQASVYINSEERSVVKDAEQDATVSKAPAKGKGNAKGGKGKSGSSRSKKPTAPKPSKTEESTVVTLLKSEVPVEISVGDFTRNVHLTMNLDKVSGKLDVAVKNSGDDVKSQDIEKVKISVITKAFVPSEDTHDPVFPFGGTTLNVLGLLRNTGGAVSECVTDANPATHLKLLFSSKELCDRSALISVRFNWHYSKMSAAAPGLRHVPAVDEQQNLKGDTSEGAVPVGGLAQTIIADQGGKNDSGWGCCYRSIQMVASWYLLQYHTIRPVPTHDEIQRYLQEKDPSHVGMVVGSSTWIGTVEAGYFINWYLKYDAKTFYLSGVNDFRNYNCVIANHFQKVGSPIIMGAGMFAYVILGICMGAQTGKGASNRRCDCWLLASAAPECCTLAQPQHLYGEYHKIAGDVAYLIADPHYVGEDSIKSIKTKGAVAWKKIDFITKAANGSFINLCCPQLDRYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA65</accession>
    <name>A0A061DA65_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769792.1">
        <property type="nucleotide sequence ID" value="XM_012914338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA65"/>
    <dbReference type="GeneID" id="24566147"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400980"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="148" mass="15901" checksum="05D2F237CD1C5889" modified="2014-09-03" version="1">MSDKKPTESDANGALNTIINFLGIDSGKLVETLGSKIADRINKGEIDYNQVVVICGNKIDYLVGIYIIVPIIAIFVVGAICFVLLALLNMAFNGLENFQDWVEETWQSFSDEEILMNNASKAATGGSNVVNKVVWIGGGSNSANSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA1</accession>
    <name>A0A061DAA1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="15">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0209520</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="15">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="15"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767985.1">
        <property type="nucleotide sequence ID" value="XM_012912531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA1"/>
    <dbReference type="STRING" id="5866.A0A061DAA1"/>
    <dbReference type="GeneID" id="24564340"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209520"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="13 15" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="16">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="17">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR95799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="287" mass="32445" checksum="775238BCB5AAF7C9" modified="2014-09-03" version="1">MASCNYGLIRRCAARFSPREITFSVFRYGPERYQRPRMQTYSVDTASCGPMILDALIKIKNEQDSTLTFRRSCREGICGSCAMNVNGENCLACLRSIDSCAKPGGQIEVQPLPGMFVLRDLVPDMTNFYEQYRTVQPWLKRKTPKPGEAEFLQSKEDRARLDGMYECILCACCTTSCPSYWWNPEHYIGPAALMQAYRWIADSRDEYTVERMVDVNDTMKLYRCHGILNCTRVCPKGLDPAGAIRKLKAEVEASADESWTAVAASEIEKRNARLLDSGKARSTEGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAE3</accession>
    <name>A0A061DAE3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0308510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769133.1">
        <property type="nucleotide sequence ID" value="XM_012913679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAE3"/>
    <dbReference type="STRING" id="5866.A0A061DAE3"/>
    <dbReference type="GeneID" id="24565488"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308510"/>
    <dbReference type="OMA" id="SIFIEPM"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="370" mass="41821" checksum="B8C77864690DE56F" modified="2014-09-03" version="1">MSRVVDGLYVGDLYTAHRLFDDVRLPPDRRPPNRFESGSAPDNLRGVISACFDAPEWCSESAGCFYQCDGHESAAYSHLIKSPRFDSDYINLHVDRIPHYRAHQASEPDSDENQSTYVLHMVVNAEDASNEKLFRAFPFAFDFVEAVSTLCNGSTFVHCMMGMSRSCSLVCAYLMKKQDTTFTSVIKQLKSVHPIASPSAGFMCQLLLFYKHGFEVPNRDVFWSEYIHLIRHIDLDKPEEYEAKCRDPNSEADNGTVYSCAKCRQTLFYGYNVIQHEGVADSRDAASEPCSSVFVEPMDWMNDVDSQTGKIMCKNTRCSSKLGYYCWYGRRCSCGHLQVPAFQIQLSKVDKLVAESRLGGTKPVRNEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK0</accession>
    <name>A0A061DAK0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MIF4G domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0400700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769764.1">
        <property type="nucleotide sequence ID" value="XM_012914310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAK0"/>
    <dbReference type="STRING" id="5866.A0A061DAK0"/>
    <dbReference type="GeneID" id="24566119"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400700"/>
    <dbReference type="OMA" id="IMHTCIM"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="78"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="370" mass="41852" checksum="2436EFBACFBFE519" modified="2014-09-03" version="1">MDKIEPFTPAYATAEAQGIPEEASGLARSSSSASESRDCTDDALPRMANRGTSYADAPPGLWRTLPRQNTGSFVEVLSRQLKSNLNKLTIEKFETLAEKIATQCEALEDYNQLQVAADLILSKAVQEPEWSEMYADLCLILFWRSREYELSGKRATFASALLTKIQREYEATPRDLDAVRATLGDDPEAGMKRLKTRILGTVKMIGELFQRRILGFKIVSKVVMDLVMSSDEPHEHLIECFLQLIYSTGYYIDQHPNLRPVLDMWFGRLKELMLKTCYTKRIKCVMQDVLDLPKAQWRKKIHRDTAQALSDLRDQVQTEDILGGSAVAAQYGNIVVVGERRNLGAKCTYGDYMVRQEDLYKAKKSAGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAL6</accession>
    <name>A0A061DAL6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768130.1">
        <property type="nucleotide sequence ID" value="XM_012912676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAL6"/>
    <dbReference type="STRING" id="5866.A0A061DAL6"/>
    <dbReference type="GeneID" id="24564485"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210920"/>
    <dbReference type="OMA" id="YFEADIN"/>
    <dbReference type="OrthoDB" id="366473at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596152" evidence="2">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="305" mass="33938" checksum="7573BCA5DDE699A2" modified="2014-09-03" version="1">MYCWEILAALILSVWSHHLLGNTLDVPPTVTEGAQPRKLFLGLILGAAKAIFNPIVNAVGSIIGGGSPAPPPPPPPPPPPPQEEDTNKDSSRRSRRRRSGSYDDSDDSGSESDDEDYRRSRRRRRSRRSRKSSDKDDDSSKEKDATDDKTGDAKPDESKDESKDSKPEENKDESKDSNPDESKDAKPEENKDESNDSKPEENKDAKPDESKDVKLDESKDESKDSKPEENKDENKDSKPDESKDAKPEENKNESNDSKPDESKDENKDSKPEENKDEGKDSKPDDSKDSNNTSESSEVKDGQKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAR2</accession>
    <name>A0A061DAR2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BT1 domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768190.1">
        <property type="nucleotide sequence ID" value="XM_012912736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAR2"/>
    <dbReference type="STRING" id="5866.A0A061DAR2"/>
    <dbReference type="GeneID" id="24564545"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211485"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211485"/>
    <dbReference type="OMA" id="ALNQMYH"/>
    <dbReference type="OrthoDB" id="367250at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596158" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1035" mass="110972" checksum="2DA0C1F59F3AF212" modified="2014-09-03" version="1">MRFLHSILCLLVVGSVLAVSGSDNPDQPSKPNTAAQPGNSDPNVVQQEVSAAGSAVGGPKTQSPGQKGEPGSAGEGQQIQESGKSVGAESHGASSHELQLKGQSSVDGSVGQNSQNQSTGGKGDDRTDGQAQITQKANPEAASTEETLTPKGTPENTLPNSSGTTSSTSAPSGQTEMQNGVRAPAAASKAETPDVKHGQGSPKQTAAPAEEKKIESAQLQDKGPSADRKEDEEEKEEEKEKGDEEEHTKAKLTENQRDQKQSLQPGQVGPKGQQDSNGRTDSEVVAGGREQTPKEPAPTTPHGEEKSQLLEQKEQGPESDVSVQLPTGQGADGAPGKDGMPASGPKVTKPALPEPSTSSHQKPDVPDVDVKKPDTSEDHKVQASAGAGDSEGDQHSDEEEEEEEDDEEDEDMSGEYHATDELPEHLKGRQGKVGVATRREGGDSVARRARRNTGSGSSSSATQTEDNPAGTQPSGKGAKGANQQGPENGSSNSQAPQQPTLETLVRTGSISEKQEIVTAFLKKDLAEGPLRKIFNYKDTSKTLETCRHLTQRKPKVCKAGNIKTEAPSANVELNRLVGEYLTHSVCTVEAALNQMYHSVHQGEYISNEIHAALKILSNVMRMNTTMRERYGESEHILENLLQLFHAAEKALVSQSVQTVLYNRWALLDSVLCAVASGESNEVLDKINMDASNSSATAVVNLERFINSSTEVFVKAYKPFAELLRVIENGVLIKALELNKNEFREQAERVVQTITERHVSGISPATLTPLAQIPHSGMNTADIQRIAGQMGNSVSLVQRGQDVTQAGAVSATTALRTAVLSLNIFKISGDHITPEIDESAVRTMVRSALLSFSEEEMVSKLIVAPQAALRVIYETIKLLVPIPAENGATAVTSDDANSRIKEIERLMDENFRQVNQAVSRSLSTSARATLPEAALIQTAVNHLGGAAPAKADLQTRATFTVDSRQEGANLEDNTNKYIEEQQFQKNMDNLVHIKSYSSVSVYQTSKHLRSGHPRRNRRYSSTSPRCHLLINTRNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAW1</accession>
    <name>A0A061DAW1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0401840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769879.1">
        <property type="nucleotide sequence ID" value="XM_012914425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAW1"/>
    <dbReference type="STRING" id="5866.A0A061DAW1"/>
    <dbReference type="GeneID" id="24566234"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401840"/>
    <dbReference type="OMA" id="KNPEDHI"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="205"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="572"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="651" mass="73366" checksum="C6C56C24EDC12CEB" modified="2014-09-03" version="1">MVKVRKNRIAKRSAAQPFPAFRASTAITNPHRTGVKGKKEGQYRDKATIKRLNMYRDKPNLEKMRVQATEPARICPDRRWFGNTRVLTQEQMTNLRSELEEAASHPRTHILKRSKLPLSLLKNVEMADDNAKILSLEPYEQTFGAKAVRKRPKLAASTVEELAELASSSSYDVSKDAYLQRENVAESSEEAPNVVFKKGTSKRIWGELYKVIDCSDVIVQVIDARNPMGTRCHRLEKYIRENKQSKALILLLNKCDLVPTWVTAAWLKHLNRTVPTVAFHASVTNPFGKNTLVQLLKQYSQLMKDRKHFSVGFIGYPNVGKSSVINTLKGEKNCKAAPIPGETRVWQYVSLTKRIHLIDCPGVTPIEDSDEADRLLKGVVRVERINDPENYIDRVLEIISRDVLVQRYGVSADFTNDNFLDLVAEKFGKFRKGRVPDVSTAARIVLYDFQRGRLPFYSEPPPADQSVDQAAEIKDHIAELGRLQLGTDLTEPVGAEDVESGAACVESCPEAEESEAAPAKKHHVRESSVPSQIAGIDYNSFLCAFAFKLRAVCGIPEDARLFRRSVRAFALPGTVERISGILATKFEKKAEEIDPECDFLKEFGADNLDEVEVLLAVEEEFDLTIPDYDFSELRTLKALADYIDRRKARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAX3</accession>
    <name>A0A061DAX3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0402940</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769992.1">
        <property type="nucleotide sequence ID" value="XM_012914538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAX3"/>
    <dbReference type="STRING" id="5866.A0A061DAX3"/>
    <dbReference type="GeneID" id="24566347"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402940"/>
    <dbReference type="OMA" id="HRTPRYN"/>
    <dbReference type="OrthoDB" id="366325at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR97806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="432" mass="46457" checksum="86DCB14AA216A9A7" modified="2014-09-03" version="1">MRQPGDLGFAARAGGGISNPARHRFTVLPSLKFEVVLACLLGVPYAVVATLLCMCDDWSTRTAFLLSTCFPLAITSYSALPKLVKALQLKGLCNINLHQKEGSERVAEPGSLWACLLYLIYLVGLGAANAGPNDIAIFNCALVAITTLTILGLVDDIVQLGWFSKVAVPGIVAIHICKAFPRETVLTVPRVLPLIGGHAINIGSAYYASLVLLAIFFVNAINIYAVGESAIIAIFVVAHNCLELSQLIGAHNGLEAAASLERHLVSLKLTLPFLAVSAGLLCYNWYPASIFVGNIYTSMAVITQESFPNKVQGALLAANALLCGTSALMLLLFLPQIANFVLSIPQVCYKWLQAIHICVAYRNQALSAFQDPVVSYVPDLLEYSNNYTLLNALLWLLGPMAERDLSVLCLGIQVLCCVIGLAVYHFAVKHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB00</accession>
    <name>A0A061DB00_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anonymous antigen-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770027.1">
        <property type="nucleotide sequence ID" value="XM_012914573.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DB00"/>
    <dbReference type="GeneID" id="24566382"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403290"/>
    <dbReference type="OMA" id="YVNGVHD"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2592" mass="283408" checksum="03523FFE9AE01B4C" modified="2014-09-03" version="1">MAVSRMRRTADGGVAQAVASVKEHQKFKKMLMFGMRSLSDFCNPQLQIHVDNALDALNRNVLPSIVTALSNFGDDEDIIFSCSQILQAMARACMEESENPEISQKFLKEGGMTAVELILNQCPQDDTVLGYCYAVIECFSASNSLADGGASLTGTICKSVRNKESMPVPVATRALVCLSAICASSSGPAKMKQHEGMAVLLQLCLLLPTEQPSIGVVERSMKAATAVAAAKMVDQSSLDPVIQVIEKFKTSKIVLSHGSDIVKSLVSTASLKQSLQDIQKCAAGSPEHKAAVDTLRSLSYISSVGEQLAKDGALGLMVDLIKNAVSQMETHKEVMVNVISVAARILGSVAANRSYCEEVVNKGGVDNLVAAMQVCMEYPSCIASIGDALAQLLQAGPAAYLKTDAVAVALPILYQLSDKEDVASSLMAFVAAASQKDELQPAFISNKVVEIMCTCCQYHSENLPLHLNIIQVLNRFSSQVKDLSLVYEYGGLQGIAMSMAAHYRSDKYCLEVLALLLTFACTPEAHQYMTTGEESIIDIILQLMLEHQEIEAITSSAVKVLEILSTEEDVQRTMKGLSLSLQTSRDNPDGAYAKIAAVTGLSRIARLRPSILSSGMPKEIMKSVSTWVESSNFEGRSKLTKAAMQSAVVASEDAAECVAMIQKVCDLACLPQVKRVIDLEGADDNFLLHCTGALRQMCSVERTYSPEECTTVVESINRVMRKHVDIKNAETQCIEALHDFVQVTGKNGIEALISTGAIVGVVGYLIKIPMYLPCQIAGVGFLLACAKMDYRALECLKQCNCYQLLRALNRTHKKSRKLKAMVGVLMTMIMPPEAFEAELTQLLIDMAKGQETNDIVAVHTALMSMNQLLVAKECIRIAARLGVPEALTKACTWTLKNKALAAKVQVVEPGDLAGKDLVDGILFEVAQANFNMGQNRNGLIAMTKQQSHLTSLTVYQSLESPVTTMVEDGACAALDGMTLLFLHNRANVEEALQNDVLAKVCRGFTMFQGCPNVIRSICRCLASMCITEARVKSLVESPDFVKLTNNLVSLVNSDNNEVALNALKAISELLKVNSDVLLNYFATKTNTIPVLFHKIEVHPEDPKIVALSASCLNCYGKNVGNGRKDIPAVLSNITRALKENKNVGTTVLPILRLLLNLANQETKQALKSSGVMEIVSDVMMIHIDDEEIAAAGGELFGFLGAEAQIRALMRSVIDTVKVQQDDMAQQVDSMCIRLAMYLLSPLENRADALAETEEFLGALNTCIAYAADNKNLVANATLVSRRLCDSVIEDFEDQFGAWAVANSSNLQQIISVLNSEYGASNVKFLCHAYRVFTCCAVNPYVTDLMQAECETVLPRSIELLDRYQGNAEVCHAILEFLNHLSKSPATENSAQNSGSQLIYSVCQQNNADMISIASNLMINHKNADNVVIPAMQLIGELVGGGSYQADKAAVAAAMSAAERVCLGDVSHQRKLAYMEMVARVLGSLETKDAHRLMENVVQMMNAGVIERNPATLAAYARLLAGAILADPENKDNMQQLNKMGAIKVLADLLDDRSLFDKATVLTVLQSLQSCVNGAPASAVLVLKEALPKLIENGSDLLTNDPDCSNAFCDLLLDAVKIEGVGRVLGGMEPVMNQLHNLQMKAKDAGNKELESRVLQILKGIAADQPKIRNCKSIYLMLEERKSEGQTISIAQAMELADDANFLLKTMTAYNNKVLAYEEDNGKDFIYGSMAFELLYSVVDNCQYLTDNGVLETQMDSLSKQTHLNISNSISAALCAGCLHPVFVAKILTRPNSVKQIGDYLKRVHSGNGMIVPATSEGSDNIAEVVLINALLLVERSAVNRRIYLKSDVINTVVDVWDAYDQHKYETPRLLRQTFRTLRKIVAEGHLDIMLKCNMVARIKQILATTEDVNLIPDALFLVGSMAVVKQIKTQICELGLLDGIVHLMERHVGNPDSPNAIITNTCLALANACIGHRQATDRFLQLKGPELNVRILREYAESHEITNGASILLCNMLYKNDNLKGTYGKLGAPEALVRCLRAYAGSNQGFAIRCIESLFKAISNLALYASNVALFLSAGIEDSFRAWLADLEPSFSDAQLKTGLQTLSNLVMDNREENMRKFSVVLPPVLKVLAQDRQDSKVALLLFDILASLCRLPDNSNTFLESGGAEMCIQTMRRVSYDLVTLTLGINLLAIQAGNPAGARKLLELDVFSLLVANLTFEEHTPEMNDILIASLRCLRKLVNCAEMVYLFCSQDGLAATIAVSRKTQQHPVILIESLRLILGMLQLTEGKEAGAAPAWENIGMEKEDIDTLLGIVCVCGANEQAQKMARLQKILFSVIAYFLSQGLGNEALIVNNFSAIGNTYLTNFPSAIDVITLMTVLLENVFTAPVEVRNNLLSREMVKRYRDVVSALPKKKPEEKTFYTRCQTLVNALASSEERTLESTGHFDIALSEWNVDPYPHGIHDLPEPVKQSLRTGGRVKGYIRDSTTRVGIRWRSSQDLNYLEWGPEEEEYPYRIAIRCIRNIARGLRHPTLEAANAKEPRKVNNNNCFCILGSATEDFPDGFALPIKCKNVKERDAVVELLVQWRDAATYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB06</accession>
    <name>A0A061DB06_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767091.1">
        <property type="nucleotide sequence ID" value="XM_012911637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB06"/>
    <dbReference type="GeneID" id="24563446"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200620"/>
    <dbReference type="OMA" id="HAGQREQ"/>
    <dbReference type="OrthoDB" id="340921at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596166" description="PH domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33571" checksum="3A836037778BDD64" modified="2014-09-03" version="1">MRNLASVAFDAALLLALAASCLGRLPPGVLAINRPNASATLGSEAATPKNTEVEHVEEAEIGQSQGVHNLDDEIRNHEMLDLGRQDDFFLPKNGGGCDVLLDDVIYVALEPRDILKTQQFVGSITPSELRLYIPDRKKVNGEAKKLGKLFARFSLGAIVTPLETLRSSRDCFRMFYKSDPILFCARDTGHRDFWMHALLKAKFCHTAHTVLGKGSAPDVAAGPAELPDLSTKAQRLYDLLHPKSSTEDAAIAAHRDSKITNIDITNINSGEPQIYLNGEEVKSEEPTKEQEALLKEQSERSQNDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB26</accession>
    <name>A0A061DB26_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Optic atrophy protein family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0403640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770062.1">
        <property type="nucleotide sequence ID" value="XM_012914608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB26"/>
    <dbReference type="STRING" id="5866.A0A061DB26"/>
    <dbReference type="GeneID" id="24566417"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403640"/>
    <dbReference type="OMA" id="KMYVMNL"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="158" mass="18205" checksum="BE07D5CD52B23335" modified="2014-09-03" version="1">MIPAFKLLAVFLKQVSKPLASYLKKRASRNDRFRRICISIGNRSYAFDRYITRRFYNAEQGEPDTTPWISPEKSVVIGTELFGEIIVFTVATLLVLSEYARGVRKEAKKEAKLQERLGTLESKHAAIPHLIRDEVSRQLAQKWNELEKRKNETSHNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB45</accession>
    <name>A0A061DB45_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mov34/MPN/PAD-1 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0201070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767136.1">
        <property type="nucleotide sequence ID" value="XM_012911682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB45"/>
    <dbReference type="STRING" id="5866.A0A061DB45"/>
    <dbReference type="GeneID" id="24563491"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201070"/>
    <dbReference type="OMA" id="EYFVHFH"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="4">
        <location>
            <begin position="32"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="314" mass="34932" checksum="35E10BE8ED8533F6" modified="2014-09-03" version="1">MADGKIPQSLLGDISDKLGSKCFQLSSLPPVKWKLHPVVIFTILDSYMRREEGQHNIIGTLMGIVTEGNVVEITDCFVDRHSLTDEGLLQIIKDHHESMYELKQKVNPKEQVVGWFSTGGEMTELTCAVHGWFKQFNSVSKFYPQTNLYEPVHLLVDATCDSGSMVIKAFVQLPLNLTKEACFQFHEVELELVTSPNDSIGISTLLRSMESAKSRKADRPREASTFDIALSKLSDLLDACIKRVEAALSGQKGAELDPEVGRFLLRATTTESIISQAKLEKLSELALQDNLMIAYLSNLANLQFALAEHLNASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBA8</accession>
    <name>A0A061DBA8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768380.1">
        <property type="nucleotide sequence ID" value="XM_012912926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBA8"/>
    <dbReference type="GeneID" id="24564735"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300990"/>
    <dbReference type="OMA" id="CHEVETS"/>
    <dbReference type="OrthoDB" id="366312at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="231" mass="26065" checksum="A8861863701D30D7" modified="2014-09-03" version="1">MFASGVDVGKVVLPKFSLRSTRCYRSLNLKQKRNCIVAKLAEIPIHHQSPEELLKTVVGGKARFALFSVRNAGSNCIVVNRNFWLRCANAVLHHSNNFTATELIRIADSFGKVKHQDSSLFKEIAVRLLKCHESWRLNDIPRLLSAFRACSVFDEQLFSSALLIIQKNLESIGADDLTSILHSLTVTTEQALFRQILDDLVSPIFTKISNFSLEVDIQTHSNLTRRISLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY8</accession>
    <name>A0A061DBY8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0204280</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767456.1">
        <property type="nucleotide sequence ID" value="XM_012912002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBY8"/>
    <dbReference type="STRING" id="5866.A0A061DBY8"/>
    <dbReference type="GeneID" id="24563811"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204280"/>
    <dbReference type="OMA" id="MIMPIEV"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="65"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="349"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR95270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="644" mass="70506" checksum="2C840694B1F79565" modified="2014-09-03" version="1">MAACATGGFQGVSNAIVGKRLCIRNVSFTVITAVLATFVSQTLQVTATPALAPVEVPVGSFLTLTKQVSTLGPSSNDVDALNELFDAGTDVFRLNFAHGSRISKLRLARIVRQLEQTDASGARSRDGSTIVRAKALLGDVQGPKLRVGRFVPNPDAKGVSPNSAKAEFVNLKKGDLFTFDTSDARGDSRRVQFDFPEILRQLEVGNVIALDDGNINMRVVGVDRLGPSVQTEVMNDGVLSSRKGFSVPNVALPVDLFSAKDVKDAVFCYAAGMDFIGVSFVQKKQDMLYLKNILLDFAESPFYPALRERMDRIDAATLDADQEDAEIEAILEQYYTERFLPNKQAMMTEVPKKEEVGIGLIPKIETQPALDDITGILEVSDGLMVARGDLGVETEITNLPIIQKRLVQLCRLVYRKPVIVATQMLESMRTNPKPTRAETTDCANAVYDGADAVMLSAESAAGQYPTHSVLVQRTLVYNAENDPYFRAMQITREMLLNDQLLANLKGATASDVESINALVQLDVKFAKEWNSRHSALLAACEQLSNDIVTKGVDAIFVHAEDRGELLQWVSTKRYTIPIILITRNVELARRLQLTWGVKAHILPSGGDPSKFAQELAPIYVQPKRKALMVEAHSNVVDSSVSFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC46</accession>
    <name>A0A061DC46_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768695.1">
        <property type="nucleotide sequence ID" value="XM_012913241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC46"/>
    <dbReference type="GeneID" id="24565050"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304130"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7036" checksum="73572E97AEBCEA85" modified="2014-09-03" version="1">MVKLCNNSCSKGDCATCVGGSIAIGVVAFPALAILVLYILGIFYNKSLGTIFAEIRDGFRGTKPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC64</accession>
    <name>A0A061DC64_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769808.1">
        <property type="nucleotide sequence ID" value="XM_012914354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC64"/>
    <dbReference type="GeneID" id="24566163"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401140"/>
    <dbReference type="OMA" id="CVTHDTF"/>
    <dbReference type="OrthoDB" id="390285at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="172"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="390" mass="44166" checksum="292EE516A402F4EC" modified="2014-09-03" version="1">MSASSSRRFAQPRLFSSHAESVGGSGSSYKALGVTAAAILGSGIYYGYRKGVLPGFSIPLQLIDEEGFDSSDNLVVVLLASKRMQDYPKSQIEKLKSIVPDGVKICYTVKGGSDSSKPPVMLYKGTRKKFYAEIDLLEKSQFEDMASEVSAFFEAVSQDFGALRQDPNIPEYVTHDTFREKVIKEATAKSPIVLQLYEDSCFLCFLMRPFINSINRHLREIKSNVRIKRLNIERNDFPEGCPVTRATPTFIVYDGQPQGNKWSEFRPKDFVAKLVELAKLDEKSQAYLNQLTEDISQRFMLFGRWARWVGEAQIIQESVLTEAPVDEEEVNTRALRLLMDMDMDRTDDLETNLEALRKEIISAEEDCVAVSEVMINEIIKHEQKYRSDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCB7</accession>
    <name>A0A061DCB7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767641.1">
        <property type="nucleotide sequence ID" value="XM_012912187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCB7"/>
    <dbReference type="GeneID" id="24563996"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206130"/>
    <dbReference type="OMA" id="AFSHEIN"/>
    <dbReference type="OrthoDB" id="365768at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="512" mass="56481" checksum="2A7ED30A82CBD589" modified="2014-09-03" version="1">MPVTDTPQTRVRAFVGETPRPRIPLKKPCAASGPQLSSVSRIRSALGEHGSASAATNGGAATASAQGRGYASVPRWPMPSDYADASLSATREAQSATPMHNPASSAAETTYAPAGSAARQRIGRPSRPPGSFGAEAAGVPMYASTSRVHSMPRPIGGGTSVGRDDHSATSTTRDGFPASRLFGDEFASATTSRMFRGSPNSQEVVLFAVHPQTVVRPLRRAVRQVYTRLLEWLLDVLRRRGMQRRVALARLNRTRWFARLFDYTALERMLNIFKLYLSQSDALAVPREFVDVYDAFSHEINRYCLSDSIRPRGENARAHRALVVGGIDFTEETLKSMTRSFEPVHHPSQQTPMMPMHMQSVGLSGSTGAANAGGIASPTDPSGASTSFSPEVSKASINRRYLVTQYNISVLVSIISRLQGIMRQRQKTLDDLNKEREELGSRLCERRRALFERCRSLTERHILSDSTDMEKTLQDIQQQFDCTGTNRTSKVLEDIERHMRVISRRAKSLSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC5</accession>
    <name>A0A061DCC5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767656.1">
        <property type="nucleotide sequence ID" value="XM_012912202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC5"/>
    <dbReference type="STRING" id="5866.A0A061DCC5"/>
    <dbReference type="GeneID" id="24564011"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206280"/>
    <dbReference type="OMA" id="SAFKMDL"/>
    <dbReference type="OrthoDB" id="363546at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="148" mass="16801" checksum="8C0C9BB4677B98EF" modified="2014-09-03" version="1">MGHAGGGSDGLSSGNLEDYSHGLQQSGIYWETGHRTYVPFWWRWVQKFTPKLIDDQLRAIIGHAQPVAYEPFVFYGNSAYFRSYVGDPDVSTVHALRRRTNYCFLPTGGKSLAVLESELQKRGDAHHELREKVFHEVLRSAKALDMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR3</accession>
    <name>A0A061DCR3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769020.1">
        <property type="nucleotide sequence ID" value="XM_012913566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR3"/>
    <dbReference type="GeneID" id="24565375"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307380"/>
    <dbReference type="OrthoDB" id="10357014at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600273" evidence="1">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="11427" checksum="CD57736E3AD135D8" modified="2014-09-03" version="1">MKASVGAIFRVLLFVLFAIALHVRANKRSWSVEKSRKRKYSEHGEYSTPEVEFYVKMKPINAPKKIRLRKPPSTYTAIGSNNIYYPWLPTVSNMGAAIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD10</accession>
    <name>A0A061DD10_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769205.1">
        <property type="nucleotide sequence ID" value="XM_012913751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD10"/>
    <dbReference type="STRING" id="5866.A0A061DD10"/>
    <dbReference type="GeneID" id="24565560"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309220"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF276">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_53, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="879" mass="97190" checksum="C38323080BF04E9D" modified="2014-09-03" version="1">MTSSVLAVKKTGSGFSGVSSGPLPLRMLSVLVLMVTVSLNVPSSVALETRQRFSSPIGIVNNVNVASPNNFESPIIVQEENQSWNVAEPHIATINAHRVDTHSQKTESKTVPAWDYARHGADWTSGMCKIGSMQSPVDLHVDGLVSRRPENLKQVFESVLKGDTTVNTLSDGWKRGDIVYSYRHLISSVQVMRTDKVFRLSIPANEGSTFGALFTTDRPNLYMATHIEFHSPSEHTFEGSANRRQVEVQIWHYYGDDSGADSGIRSLELNEHTDMNVLVSTHDADMINRVNKVGAQRMDAESKLSSKKAEESHKSEEPAAKNDKSNEVDDSKSKSDEGDKTSSHDQADKTPHVDHFADSHQNDKPVADDVTKDVHSETYVQPSTSDKPGEHGTAEVSSASDKSTPPVVNESQSEGADTKKEEKSPYVIVDIDGNKIGQNKPSGSASATNNTRGHSEDVKSATKSVAVAEKHEEHKDSDPDDYEDIDDEEDDEVDDGEDIKDANFVNDEAGASFIEVLSDVEMADGHHVINPNFANTKPHDAVVHSVRNGSYRGNLHQEQNNTPLAISDKAENISDMHAQSTGEKLTDKHADAAKPADSADGKKKNDGTGHESHPLKSEHSKVYSDMVESEQFELLHKYLLDHLHKAAYDKEGDRRHVSEKRRARETGVHWGRWAVLSMTFMSEEMERTRIETLKSFPSERFMEQVLSVGSEVDVSADPNSSGVGDLGADNGSELPVVELDVPINLSSLLMMLETKNLNYFAYDGSFTRPGCEETVRWYVAKESLPVSTELMLQIHRMLNQTRDQTAHSAPINKYRELQNVNSNLHNSGKVHLVHAYPMEYFIAASLDHARQTPVHHESGFYTCSFGLWAIIAAVTLMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD72</accession>
    <name>A0A061DD72_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Apicoplast import protein Tic20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0310570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tic20 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769340.1">
        <property type="nucleotide sequence ID" value="XM_012913886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD72"/>
    <dbReference type="STRING" id="5866.A0A061DD72"/>
    <dbReference type="GeneID" id="24565695"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310570"/>
    <dbReference type="OMA" id="LAMFYFK"/>
    <dbReference type="OrthoDB" id="365983at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005691">
        <property type="entry name" value="Tic20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16166">
        <property type="entry name" value="TIC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600810" description="Apicoplast import protein Tic20" evidence="7">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28242" checksum="9169031E862F9C1F" modified="2014-09-03" version="1">MLFRLLYTAVLVARWSVFASAGAVARPSRAFILAAGRDLPPCTRLRHRQGGASFGGVAVRKAERPFEIRSLNSDTASILDRSSNALYETLSQGSYASPVECLAASAAYVLPLMDAVEGIHRLSQFYTQVPFLSYTMSTLIYSSLVKKNQLNTSYFVRYHFLQSLILSSFQNALAMFYFKLLPIDASSQDFVSVVCMMSAVMSSFGAVFYCVFHAIIGRFAALPIISDAVQLHIGEIPSNEILKRRTTDTDSAIAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD97</accession>
    <name>A0A061DD97_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0212220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768266.1">
        <property type="nucleotide sequence ID" value="XM_012912812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD97"/>
    <dbReference type="STRING" id="5866.A0A061DD97"/>
    <dbReference type="GeneID" id="24564621"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212220"/>
    <dbReference type="OMA" id="GKWSFAN"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="172"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="856" mass="95387" checksum="6FC5267647BB5E7A" modified="2014-09-03" version="1">MAIPKVLVVAEKPKIAEVLASSLCTDGDSLRKRKGKSNACMTWECRGRFLSSAADFVVTSTAGHVYSAAFASRYNNWSSTDPLDLFDADIVFEEATPENHIPQHLAYEAKGCSYLLLCLDNDREGENIAFEVIGICRPHLVDLGRKQIYRARFSALSKDDILRAMGSLGAPNKLESDAVHARQIIDLRVGCAFTRYQTKFFQEKYGDLDSSCISYGPCQTPTLFFCVDRYNAILRFQPEPYYKLTGEALCKGTRVRLTWSRGHVFDKSVIQIFHKAVCGIHPSVTLEQLRDATHGKVTAVSVKKSSHSPPKALNTVTMLKEASSRLGMGPQRAMHTAEHLYLSGYTSYPRTETDSYPTSFNWEDLVRKCRSTPEYGNLVETLMKSGTPLGPHGGRDAGDHPPITPVRLVSQGVLTGDDWRLYDLIVRHFLASIAGPCKVETTTYTINVNDELFQFSTSRKLERGYTIVSPSSDDNVVSTVSLAKGDKCEVANFSIEEGVTSPPPLLSESDLLDSMEKKGIGTDASMATHVHNIIARNFVKLVGNRQVEPTKLGKSLLDGYMQIDPELVLPSVRATIESYCNMIAEGKAECADVIRHVCRMFRLKFEYYTSKIELMNSLFETHFTRVENFGTPMSRCGICNRYMLFLNKAPMRLFCRNCSREYSLPSGGTIRLYKGLKCPLDNFELVQFQSRSRAFSLCPLCYNDPPFEDFGKKGMNCIDCAHPTCANGPRSVVLTCCPEECEGKLVLDVINGAPNWRFFCTVCAYKLHVSDNAKKISIVPDSECETCGSHYAKFELKDGTPLEGCVFCSDSMKKYLVNPLVLTRCSVTCAQAEEVQSPPEVQAHRTTQPRPRPPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB1</accession>
    <name>A0A061DDB1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0311470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769430.1">
        <property type="nucleotide sequence ID" value="XM_012913976.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDB1"/>
    <dbReference type="GeneID" id="24565785"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311470"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1724"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1797" mass="192993" checksum="E9C6E7A0CE31E39A" modified="2014-09-03" version="1">MAAKNGIPPLNTLKDCLVFLEWLNSGKGPKKLVVTSFVQKLKHYFPGMPGLKGPLQTEFFRFLENVSLIYKKLSSQQVTRWGTYTGKPNDILDALLECTPKLLAALSFIQYHVDGAFSGVGGGDWASLSPMSGNFQTFLTSGNNIIEGGFDAGELSSVQGGTLVEDLKKILNKDAAKGKTGYDHHRNVIMTTLEKQWNTFNTGNTALLVYAFCQLVTKTREPEGGAFKKALEKGHGNKICWQDLKNHCQHLHGHIEILTGAGFSFTGMWIGPKNVVHFAEKAGRWFRENLQKAASEMKGMIPHSIHSQMTVLQSFAEDKLYPHGFIFDGSNNSVRSKPRNLDDWNPIFQKFNQLDAMLTRLKDILDGYECGSATVVTKAEAAKPTATKTEATKTEATKHAATHVKAVQPPATTTIATPPPGGNTKGTPNQGQTVRGAQNTGSRNNVAPSQNSGQSEQKPAISSAGTSSFKPPGGIGAPVSTGAKGEKGPLGHPSTVSTTSFPRQNNVQRQSPSQPQPAQPPQAPPTGPPAAHGSTSQPGSGGGSTNGGGDAGKKAAASPAPKPQTPSGTSSRPRASVVPAPGGAPSTGGSQGLPAAGQPGVKGQGSQSGVPQSLQPTGAHVPASPQSPSVKGSGALSSVDSASGGGQGSSGAGQQYGKGQGSPGGGSQDSQSNAYPQAALSQPPSAPPLGPSLSSVPAPGNGTGSTSVTGQPGGEGHGAPGGGHKGQQPDSASSSGQSSTPGGTTQGPRASNVPVTSNGPGQVGQTTSSGSAKPGYQGTSQSSTTAATTTSTGMAPDSGGGGGVGGSNGKVDPEEERLREHLEVYGSKVQKRNYDARKNMENIWKKAQEKFEKINETKFRAKLDERRNTQTAVNRPQPPPIPRTQPIPHAPAPYPLLPGVPPGRGRDYYESRGRDIGQGNRGVQDAEIPISLGGEAVVDTDLKKLQDEWNNRIEADEKRKPLDWLNQASADLKQLMAFSLDGAEVSDVTNQVGKYVKNTMGSDVTATLNRNVVTSAMYDLDGDVVAGLDDPDMVAVDGAEIAEQKHVYSVYPAYMDGLEVDAIDGDAVMSDSDDSLVPGIDDPTVAELNGTEIAEVVHETQDKEWKAELQESYDELLRNSGFTGMSIPNSKGIWRPVDPQARTYDNPVSGDPIKAPDRPSTLEITGNPISAPNLNVRLQPLPIDIEVRDFNSRDHVLKSEINHRPALPVVENMRLASTSITHPRMPMASPDVNGNYDDSSTWGEFKDYAFDIAPNPNMCNNPWNYVNNSTTAATIPPPPDSDHLPPPTNVKAMLFWLVGLNAYGLIAKMERHMENILNEINGDTFYPKYALQVNGDLYSLSASHIADTLTEACLYSAHVLNGIMRMQSGDALSDIDFKSEYTKFCYSPDAASLLCQLRDYVYACHYQLQFLKAQCNRDKYHGGWKSYDYGSDSKVQSPLQSFLTDGWDSTFKTHLFDPYNLCHKSRVRMGFKKSDLPEKSQNGATLSAILTPSCGGDDPILTLCSYLNCITRRTPRTTGELVSYFHHIGIELHEYASKSLSPLGNSLLNPHPDCPDWDHLGLYDLGAVKGIRGSESLISKHNSSHDNDHPRTLSTLVGCGDDSSNCHPRMSPITYRAYALYSQSFAHTYLSWTVYLPDRLWESLEKLHYELKKHVSIKCSSLHLCSTALPLLYTHGFTPPEVGSQPTLTCQQVIAKLKEIVNGGPIATLMTAMDNFLFTIREPFIFTLVALWSLAFLICAKTMLYRLDVLHIRSHLIRTKASHHIDVKALLTKGRKMLSLYNDVDYFDEDPIGYVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE8</accession>
    <name>A0A061DDE8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small GTP-binding protein domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0312320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769515.1">
        <property type="nucleotide sequence ID" value="XM_012914061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDE8"/>
    <dbReference type="STRING" id="5866.A0A061DDE8"/>
    <dbReference type="GeneID" id="24565870"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312320"/>
    <dbReference type="OMA" id="YVIDHRL"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="371" mass="41238" checksum="E08515D1ED334187" modified="2014-09-03" version="1">MRNAIHTQATTVSWHAPQQPEDPKLVRVALVGLPNAGKSSLLNALLSSTIAAVSPKVNTTREDIKGILCADNCQIILMDCPGILESHRRRRFCAPLVDTAWRTYREADACLLVLDTVKRPDAELFRIVRLLAGAAPCDTGAVSEAGDGHVGDMDHRPSYPEAAGADDADPDGTELFDEDEPAALAGGEIAAGGHEPCERRKPVALVLNKIDLVQHKKWVKARTREMKNHGTFDDIFYTSAKHGIGVERVLHFLKAVARPGRWVYPPDMLTTMSKVQVVEQLVRTYIYCWFNKELPYQVGQKVIGWTPADNGSLIIEMELYVRNDKAAKIICGIQGRIVKQMQKNVSHRLSKMWQQPVFLYAQVKVKPAFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH0</accession>
    <name>A0A061DDH0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA large subunit methyltransferase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0312970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769580.1">
        <property type="nucleotide sequence ID" value="XM_012914126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH0"/>
    <dbReference type="STRING" id="5866.A0A061DDH0"/>
    <dbReference type="GeneID" id="24565935"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312970"/>
    <dbReference type="OMA" id="VNRNPFR"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="465" mass="52702" checksum="25497D163A15EE98" modified="2014-09-03" version="1">MGKRGRHESKWLSDSELCQQPPRRSEPSGRSCMHHRSRHTNRDDFIALSRVFPVLKQHLVANSKWKSSMSKHLMYHYDFSHPDAVYHLSRAILKITYGLNFYLPCGCRNGACDPFLRVESGEDDCDTYLDDSECIDVQRYLAPCIPGRANYVHYAADLLHVSHNLPDPPPEGTDPPFPDSSNISFEDIPRGQGVKVLDVGTGANCIYPLLGCSEYGWSFIASETNLEALTLAKHNLRLNGMTGIVDLRHQKEPLRMFTGALQPNEFVHLTMCNPPFHASLDQTNMNPRVSTCGTTSELTFQHGDVTTFSIDGVDLHNLQKVRFGVTGQVNYTFSSDPAEQGELAFVEIMLVESRFFVHNVLWFTSLVARLSTLKRIKSHIHADMRLYHASSSKQVAFLDARVSDLLREEGSSAGCEDTFHIPVSNLHVCELRTFTLSQGRQTRWVVAWTYFNAEQRYKILKKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH2</accession>
    <name>A0A061DDH2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768451.1">
        <property type="nucleotide sequence ID" value="XM_012912997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH2"/>
    <dbReference type="STRING" id="5866.A0A061DDH2"/>
    <dbReference type="GeneID" id="24564806"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301690"/>
    <dbReference type="OMA" id="NDEHAFT"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF" evidence="1">
        <location>
            <begin position="18"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="368" mass="40629" checksum="755812DF85481AB1" modified="2014-09-03" version="1">MVLAPVTLATKHGKNISSELKSTITQGKIPAMEYLGCGYDILYGNPLIDDGSLVDPGYRNPIISFTLTQYRGKARKDPKYASVPGAWIRPLVSCRRSSERTVVKSMKDYQKALAVDSEVGFGSIDDSVKFALSAGYAESAGINLSKTRRLHIQRNYCFLLEAALPVNGQYAFKKSFEIAVSLLTPNFRTSSETCTTIRYSMNPDHPDCVEHVKPWMNLFELFGTHFTYNIKIGGRLTELEQVNASKSGKRSNAQAKARADIQVTKSVAAGSVGVDGTKMSNNSNMTNVSFSYVNVLGGSPIGNADDEDEYLAWIHSIPNNPMPIRSQLAPLSKLFRSQALKEAYDDAMEFYMALNGLRNYPEKKEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH6</accession>
    <name>A0A061DDH6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytosine deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768461.1">
        <property type="nucleotide sequence ID" value="XM_012913007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH6"/>
    <dbReference type="STRING" id="5866.A0A061DDH6"/>
    <dbReference type="GeneID" id="24564816"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301790"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="18595" checksum="327B0263BB63AC44" modified="2014-09-03" version="1">MLSEEDVDRFMAEAIAEARSALESGEVAVGCVIVDKESSSVVARAGNSTNKTHNSTWHCEFGAISTVFELVPGGKVGCGDRDSLHSFMSRYALFVTCEPCVMCVTALQIVGLTEVYYGCPNEKFGGCGSVLSLHEGYGGMAPLRCVKGIRADEAIGLLQAFYSSGNPKVHMIPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP3</accession>
    <name>A0A061DDP3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0400760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769770.1">
        <property type="nucleotide sequence ID" value="XM_012914316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP3"/>
    <dbReference type="STRING" id="5866.A0A061DDP3"/>
    <dbReference type="GeneID" id="24566125"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400760"/>
    <dbReference type="OMA" id="SKINEYP"/>
    <dbReference type="OrthoDB" id="366141at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="264" mass="30649" checksum="F10EBDC04A06C4CD" modified="2014-09-03" version="1">MTTGHDASCCICGEAAKYRCPACLKQTCCLKCVAAHKERYECSGRPQPSYVPIQEMTDQTLSNDVSLLDRISRVIESTSRAFVQRQIDAHVKASKRIKTAALRKCCDDRGIILQLCPSHLSRHLRNYTCLRKGNMYWTVEWYFAKPDILLFERRVSEKCTIAKALERVLMRVAGKRNTANLLREYLDIHNVVILIRDIGEINNKSRYFMCDTHFTLRESIEKTRILEFPRIDVVLKRDLHLYKIVERRSQTSPEDGKIVEEPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDZ4</accession>
    <name>A0A061DDZ4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769995.1">
        <property type="nucleotide sequence ID" value="XM_012914541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDZ4"/>
    <dbReference type="GeneID" id="24566350"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402970"/>
    <dbReference type="OrthoDB" id="10427525at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="282" mass="31393" checksum="9E670410958A1D8C" modified="2014-09-03" version="1">MWHNTFQTARTLPAGLVRPMSCNASVRAYYKAAGNLNRNKGRSFLATGRAAVASPYNTQFIKDVKGNECELLMRKYSFMVHRLYDYIKKLTMQETSSRTGAEYSTDFPNTLLPMPSKAAQEGEGFHPLSSGMVGPNEYKSYMGVQYNHMANNSYAYTQPCLNTPAMLNVRQPPYGNVLPVPSSVMPQCQPYLCGPTPTLMQDGAPVQAVMQHPQCAPMHGMMPRYSPLFGCSYEEKYYTPALMNTHVAGPWNAHPGDMNNHVHYPTGYTPIIDCLGGVPRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE51</accession>
    <name>A0A061DE51_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0307290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769011.1">
        <property type="nucleotide sequence ID" value="XM_012913557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE51"/>
    <dbReference type="GeneID" id="24565366"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307290"/>
    <dbReference type="OrthoDB" id="364982at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="10144" checksum="0DB0267D9B88D73A" modified="2014-09-03" version="1">MVIAARIGSVSCGDLTYRLLAVGCEARCRNMFPRQVTKDTVASPYDNATYADFGDIKLFSCLEACRMALTAYPKDEEEIRRNDEISKSRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEL1</accession>
    <name>A0A061DEL1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ubiquinol cytochrome c oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0313720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769656.1">
        <property type="nucleotide sequence ID" value="XM_012914202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEL1"/>
    <dbReference type="STRING" id="5866.A0A061DEL1"/>
    <dbReference type="GeneID" id="24566011"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313720"/>
    <dbReference type="OMA" id="TICKSVH"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="352" mass="39629" checksum="82D753E157BE48C7" modified="2014-09-03" version="1">MACTYYIMAARRNFASILHHEMKKSAHMPAASERPLYRNAFDRAEHASLWALDKTKFERTKPTESLADLITPHAHGHKFTNSGITKYAHYVNVWEPVFPRTPDVQKGELISGANFTRTSGWHLPGEPAIVSVGKLAPDNQRAIGYAENAVVPDSIAPDVFPDFSEYRLPKGTDRRAAIYLMSATAMFFFLALGRSIVCKVIHFFWVARDVAASGSIEVNVSQMIPGDQITVKWRAKPVFIKRRTREEIERSRYENIVLSYIKPCRKDDEIVDSMRDPELDSERNVNPEWLVNIGICTHLGCVPTKGGNYGGYFCPCHGSHYDASGRIRQGPAPSNLEVPPYKFIDENTIKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET0</accession>
    <name>A0A061DET0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0403030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770001.1">
        <property type="nucleotide sequence ID" value="XM_012914547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DET0"/>
    <dbReference type="STRING" id="5866.A0A061DET0"/>
    <dbReference type="GeneID" id="24566356"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403030"/>
    <dbReference type="OMA" id="DWVVFNE"/>
    <dbReference type="OrthoDB" id="360515at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="5">
        <location>
            <begin position="429"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="712" mass="79020" checksum="FA285DBC5458215E" modified="2014-09-03" version="1">MANAILSQRDEIVAAVEGHNVVAFSGPTESYASSYIPSFLYKAGFTSSSNCRKNPPRICVAHSRHQEVKSSAESCSVLINNPSKVACHLGSAASLDSTADIVYVTEDCLLRRLVADPLLSDYGVVILTGLQDRLLCTEILLALLKRILSKRSRLRIVLIFEGGNVDDVLTFFRRRATEKDTAAETSPSCGDEVSKPNPGSLLPLGDVYHVHLKCDSISYKVQYLSAPCPNYLDAAVSTVWSICRSEPSGNVLVFVPSSEELELLHTNLLESAKSFREQGAGSLNVVPLGVGGSTEQHIKKNPYASRNIYICCDLKDYRSKVDSIRYVVDCGFSRRMVSDHVNTGSVACTVTATRDEMRRRSNIIRGSGKCYRLLTEAHFMDNSLVMEFPISEMKTTDLTTMILFIKSLGVADFSDFEFVVQPPIDAIEHALTTLFLLGAIDGNGDVVYPCGNVMAELPYTAMLSNFLYRSTELGCSAEALTICAMLEVQDIVLKRGNVKSTYQTERLQAAMRGFAASEGDLFSYFNVYQLARYYRDEDSKWLGRHMVSGSGIRSAEKIRSQLAALLKKYQLPEVSCGDNSAVLLEAVFKSFFLNVACKEHLVRTLLTSRHLDVGLKVKSKVLDDEGNAILTNELQPYLLVASLDTSKTRRLYIHSGSFLADEQPDWVVFNESMDIDGEYFMRDVTAIQPEFLQKYAPHYYGEVQVRSYLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEU6</accession>
    <name>A0A061DEU6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770081.1">
        <property type="nucleotide sequence ID" value="XM_012914627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEU6"/>
    <dbReference type="GeneID" id="24566436"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403830"/>
    <dbReference type="OrthoDB" id="366437at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="187" mass="21665" checksum="5C5D5D5D713ACF0E" modified="2014-09-03" version="1">MVESPEVQEAVKELHGDVQGVLIKASMVLYKHYMKRNGSKMEKRGLNRNSKSTNETACTLDVDIKQLEDAMTKEHTCEGRRACQDKMLQLRVVRAERERKELQKLKEQIAVTQEQHKKLRNSCLMKVNELLSSFDNSQIAAYQNAICEKERLSKHGEELMQRYANLCKIQDNLKICYDGMLKENICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEV7</accession>
    <name>A0A061DEV7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770136.1">
        <property type="nucleotide sequence ID" value="XM_012914682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEV7"/>
    <dbReference type="STRING" id="5866.A0A061DEV7"/>
    <dbReference type="GeneID" id="24566491"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404380"/>
    <dbReference type="OMA" id="LERKGQW"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="66111" checksum="72C203B8192CA274" modified="2014-09-03" version="1">MSTRQIRRLRRDLEREKEDDTTPPPKLVISINKPKFSFAMLRDALDSDDESSSDAEEDSSSDDDSSSSASDHEEVVPCSTPDRYTQPPKNGRLGNKRASKPQNDDESSDEDSDMHLLESCKETNTESADVSVSATMENRFECLRIEPRAFRVVGVGTQASGKARMGKGFGGYLQGRNWLMPGIAPKTADKLRAAVVQQVRLKGNYDSKNERERFTLELSDRYKNIQSVCIAAIDTQDPALFRRVLETNPQHLEVLLRASSIHTLQGQHEEAFKLITVAVQILQAALPPRFSPFRLDEKGCYNTWLPSSCGSNLIVYRLLLLYMICLERQAQWETCLAVCKLMLQMDFPNDVSHALLHIDLYLLNYAGVGVAEFATGYAKALEYAVPLYWVLPNFAFSMALEFFAKDTNEAVTATISESYLDLLQEFLTLKEDELGFRFNPVEQDMRKYTNKRSELCLIRALVKYPDIIRMLTRENFAADLVVYTQTEPFASWMSDYDTDDVHLIKCYLAKTADLWRNENLSLLINTASLIADIYRTERGATILGTFRDLWSAFRLDQPLPLTPKEVIVSEFDLTSHSLPTALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEX5</accession>
    <name>A0A061DEX5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770226.1">
        <property type="nucleotide sequence ID" value="XM_012914772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEX5"/>
    <dbReference type="GeneID" id="24566581"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405240"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28005" checksum="DF002C947CBCF6AB" modified="2014-09-03" version="1">MTFHSLTTTPRNVKDAIDWLVALKGTNAFGNLKAFGAAIHKVLSEHPVGFKVYPSIEDGKIFTKRFLEQEALKDQPFIQELLERYNKPLDKQPSTFSKLFGLVKECDFQNVVQARHTSPADITTDVRKLVDGCENFLKKVQHSDKYRSTYSPKATWDSSCASYPEGCAKVFVGIAPMLYAGLRALKESGADAASKGPKSKAAAHLEEVMSAMGYEESRLRPKLGASDIVTALRGINGHALDAIYDFAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEX9</accession>
    <name>A0A061DEX9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">-Solute carrier family 22 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0405440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770246.1">
        <property type="nucleotide sequence ID" value="XM_012914792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEX9"/>
    <dbReference type="STRING" id="5866.A0A061DEX9"/>
    <dbReference type="GeneID" id="24566601"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405440"/>
    <dbReference type="OMA" id="GCFIMGQ"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="487" mass="53030" checksum="352F2EBA31DA1E27" modified="2014-09-03" version="1">MASLSDSETQTAKKCRFEIVDPAVMPAPHINPVLRLAIYIYYILSSGCIYWGWNGIQEILYKAGAFAELCKAGEGATTKIIYDVSYTAREGGINNLYTLAYSTHFICSFVSGWLLDRFGPRVCFMTGHFISGSAWLLIFCFPTNGRLLQFAFVLVGLACEACYIPMLSVSKYFPTASSTVIAIMGACRSLSFFVPTLLALIYHKSGVGSEMLFAVGIGYLLVANVLCFVSGFFILPKVIPIAPSEKDARTEMESTPACEVVTDSAVAESEDKKSLTIIDSIKNGFKSPLLLEFLVLGLSVALFMPSIEFVNKSQGNLLVASNGGDATGVFKYFNIATFVPGPFLGAVMDKVGPAIVMNLLHNCAILYYACAAFDIYAMKIAACCCYLIAGSLCISTAYCYVNTRFPSQYFGTLVTIIFGVAGLFSLLNIPIYNWGLTLKADIPQQRFRPLAFLFMGYMGLASVMSAILIYISVIRPKRMAALSMAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEY7</accession>
    <name>A0A061DEY7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0405840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3 12"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770286.1">
        <property type="nucleotide sequence ID" value="XM_012914832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEY7"/>
    <dbReference type="STRING" id="5866.A0A061DEY7"/>
    <dbReference type="GeneID" id="24566641"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405840"/>
    <dbReference type="OMA" id="IELPQHM"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000010">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR98100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="830" mass="94572" checksum="CECAC67B90807554" modified="2014-09-03" version="1">MQQTDTSVASSEADAALKVMYVINRKGEREEVQFDRILNRIRKLSFGLHSLVDAPRVTQTVINGMYSGIRTSQLDELAAQTCAYMAAMHPDYSKLAARIVVDNLHKNTKDDYGEVVTALFKYKYIYDSNASLISEEVYNFIMENIDRINAEIDYTRDFQYDYFGLKTLERSYLLRIDDKIVERPQHMLMRVSAGIHCGDLERTIQTYHLMSQKYFTHATPTLFFSGTQRPQMSSCFLLDMKDDSLSGIFDTLTQCAFISKCAGGIGLSCHKIRASGAYIRGTNGKSNGIVPMLRIFNATARYVDQGGGKRKGSFAIYLEPWHADIMDFLDLRKNHGAEDTRARDLFYALWIPDLFMKRVEANGDWTLMCPDECRGLYEVWGDEFEELYTKYEKAGMGRKTIPAQSLWFAILQSQIETGTPFMLYKDACNAKSNQQNLGTIKSSNLCCEIVQYTSPDEVAVCNLASIALPMYVNKETKTYDFKKLYEVARVITYNLNKIIDRNYYPVPEAKVSNHRHRPIGVGVQGLADTFMLMRYPFESEEAKELNRRIFETIYYGCLDESISLAERDGPYETYQGSPASQGKLQFDLWGATVDNKLWDWDDLKRRMAKHGLRNSLFLAPMPTASTSQILGNNESFEPYTSNIYYRRVLSGEFFVVNPHLLRDLVDLGLWDENMKQKLIAYNGSLRHIEGIPQHIKDLYKTVWEIKQKNIIDMAADRGIFIDQSQSLNIYIEQPTFGKLTSMHFYGWKKGLKTGVYYLRTQPATDAIKFTVDTNLSQMAKAANQGPRSKMAEVVSTTDGSAVSVDEIAGFPVCRLRTDPNSNEPCTMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYX4</accession>
    <name>A0A061CYX4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765987.1">
        <property type="nucleotide sequence ID" value="XM_012910533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYX4"/>
    <dbReference type="STRING" id="5866.A0A061CYX4"/>
    <dbReference type="GeneID" id="24562342"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101300"/>
    <dbReference type="OMA" id="QKNMNIK"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32200" checksum="812762DA87166696" modified="2014-09-03" version="1">MRDLKACGVCGNAFTLMSRPKICRQCKRSCCVNCVDTNYVSPRGVSPRNANKPNGQADSPGLCVDCVLTEATSHSISVQEDLDRTEEINRGLKLELKRQLVAMEKFRGFLVEFCNAFAPESALFQEGNTSENNDVHESDADKKLDQTQPIANLVARGQDSLQNLYARVRRLRSDLDAANNDGNGLKRALAETRAQLEAVAAERDSLQSSLYEINESLLRLETERQQAADLRRDCEALRARCHKMERDYNARTSPSGTQTLLQRGDAREEQAENWRWFAMCCPRFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ19</accession>
    <name>A0A061CZ19_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0100270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765884.1">
        <property type="nucleotide sequence ID" value="XM_012910430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ19"/>
    <dbReference type="STRING" id="5866.A0A061CZ19"/>
    <dbReference type="GeneID" id="24562239"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100270"/>
    <dbReference type="OMA" id="VCVVMTW"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="103"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR93698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="314" mass="36141" checksum="EC06620B12CDCD5D" modified="2014-09-03" version="1">MVAIVMPSSGRRSRLAVPVDSICVFLLTYALALQAQWTTTALALKLWPDHRFVTVLTITCHTATLSLAMWSHWMCATTDPGYIPALKDEHLIYDALRWGFTDCNKCRSIRPRRAHHCRICNRCVLHMDHHCPWISNCYVFLTGSTELALASVIGYEMYDLYHRDIDSLLSKYGVFMIVSTTVLYFVAILFTMFTFILFVDQMYQIYRNTTAIDKLKNISNREQSFMQTLTHLFGCRFSVTWFLPLPMKPRYFGAELTCADVVALSVFDESDAVLADRNHELQGLDAKDADAPRRVSCFHKLLYRREISDDVDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D088</accession>
    <name>A0A061D088_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766269.1">
        <property type="nucleotide sequence ID" value="XM_012910815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D088"/>
    <dbReference type="GeneID" id="24562624"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103930"/>
    <dbReference type="OMA" id="SHWIPEH"/>
    <dbReference type="OrthoDB" id="364746at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600475" evidence="1">
        <location>
            <begin position="18"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="799" mass="87470" checksum="BBFDA4CA59702D03" modified="2014-09-03" version="1">MRHWLLLYLLLAANAAAFVRLQHSSSISAPRAGLAYTRLCAKSLLDDPILLAPSPEPGKENEVIVSDSPAFGLQRTLYNHRRKLRARGALFDPGDCVYLASGPYRNARGTVLSTFRRAPGEPYLVSVVLDCRNERGIVRGSLSGYHGTCVTVRESQLTARPLFTPYAPPPLSSEENHGLDRRGGARNGSTVKPLTSVLLARVFNCVRISELKWIFDRMHRSGVQGALPYQAVAIQIARGLNAPQDAVDVAALLTAVLERVRLEVKKGYSDEARTSTPWLSWALGVFRNSGLVKDEALLLPIYRFIRDVLISGKLSDLTQGEIALLASGFRHCFRYCNDVLHRLAMIYSYMPAKGVVPRHATSLAAALAHAGIVHPAFSRLMFEVVKGEHALLCPSGAVHLLEYLSNDPATPQAIKDELLACCSVAEFLKPNSTPDGPDHNLALRLAWLSEREMSELLHALRTGECEMPPSAAAVALLNPRCRVPNHELTNLLLVRASRLFDTLSVKARKALLTAARLMKQCPREVFDAVDRYLSGLGADRVLDSATAQALAQFLPSIPDSRPESQRLVLEHIERFIAFTLTLLREKAIDVKQRKSVMAKAATCLQYIPMLGFELDSLARQSAELLRDGLPFASDRLSVLLGMMAVQSISPSYFDAAADAARALIADPSVGLPQEVAPLAELLLILGMHAEGCKKLRDDLMHLGLPELPPARTKKVAKPLPHRDVRDFSVLFALLVRSRLCEDWSGLLATAYVFAEDNIEALSSADLLLLRDSLVSLGAFDAKWEGLIASVAKGIDAVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Y1</accession>
    <name>A0A061D0Y1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766469.1">
        <property type="nucleotide sequence ID" value="XM_012911015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Y1"/>
    <dbReference type="GeneID" id="24562824"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105920"/>
    <dbReference type="OMA" id="KAWFCSG"/>
    <dbReference type="OrthoDB" id="361871at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599924" evidence="1">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="21822" checksum="709E85FB9F982504" modified="2014-09-03" version="1">MVDSRLCGFIAALGIILGQCVSGVPIGSAINSVFLHINNVSVDCSEDLGRMMPYNDALLECAHDINCCVVVVEEVDAHSEAPGMSRLCASCNLLNARSVKNARVSIKGHQSFIAKDFDVMLNQQGVCERDQLLGELVPVLSSTTAARECGRTDCDYFTMATLEGIENLPGTVNKAWFCSGDAKTVPAEGFITAVRKRRNYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Z7</accession>
    <name>A0A061D0Z7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRY domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766677.1">
        <property type="nucleotide sequence ID" value="XM_012911223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Z7"/>
    <dbReference type="STRING" id="5866.A0A061D0Z7"/>
    <dbReference type="GeneID" id="24563032"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107890"/>
    <dbReference type="OMA" id="RERVCDY"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="459" mass="52333" checksum="303B48AE0E60962C" modified="2014-09-03" version="1">MNELISMLYGAEEYPKQLNVRIHQHYVRVRKDHLTIEYNGKGRYCDPGSVQSELPAPKDCVLYYFEVNVVSSESPAKVVVGFSDGSYHLNRYPGNDPFSVGYRGENGHVSLGSGKWESYGSAYEQGDTVGCGINYLKQCYFFTRNGKYQGEAGRLHHCDNFPTVGLGQFGDHVTCNFVGPFKFDIANEYRRALASEQKEINAKHVDMESLDVLVYSYLLYSGHKRTLEAFSRERGAIAADSAAAATIEDCASTAADALQEEENTPEEEGSDDGSNDEIYAESIYITDEVFLRFESSLDVRHKLSNLVLSGRSFDALRLLHSAYVDVDKQSFYYCRLLTQHFLELVMNGRVEEAIRWFRGVYDFSVNKYPCFKKLLEETMEILCYKDVEAHAVRDYYGARRRLCVAREINDLAHGYDFWRNSLRVLVQFLTMGRRDLRVKRGYSGPTYSAAYICQPLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D129</accession>
    <name>A0A061D129_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0106370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766514.1">
        <property type="nucleotide sequence ID" value="XM_012911060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D129"/>
    <dbReference type="STRING" id="5866.A0A061D129"/>
    <dbReference type="GeneID" id="24562869"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106370"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="77" mass="8463" checksum="4EE06705E8F8C986" modified="2014-09-03" version="1">MDAPADPVNVAVAELVGMADMLKRMRDSCWSKCIAAVKVERMDPGEQSCVDRCVNKFLDVHTMVGTHLQEASKNAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D188</accession>
    <name>A0A061D188_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0107070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766584.1">
        <property type="nucleotide sequence ID" value="XM_012911130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D188"/>
    <dbReference type="GeneID" id="24562939"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107070"/>
    <dbReference type="OMA" id="DEPEFIC"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="476" mass="51607" checksum="A812C9A6D28BDE69" modified="2014-09-03" version="1">MAHQSQVGTPVESKYDTLGKSLYNLVSFFEGYDQQVLSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCIIWGLLVDSYNSNLVLGGGLLVMGMASIFLSSASHYKVIVFLRFLHGFGFACVYPVQQKIVADSTSSVGDKKERESKASGMFTIFQALNCIGRLLCAVITTLIARKVLLGYYGWRTSYVVLGYIWILFGTAIIFGMKAERLQSTDGFTALLRGSFEGAFRRSTTWILIFTLFIAEAPMSAFNYMTIYLQYLGVSDTMAGVAVAVTLIGGAAGSGAGGEIIKLIAKEADGPGELGSGIAVMVVRLVVCLLFFLGKPPCSKLLWYHYIELAALGGTLVTVGGVDRALLKKAIEDKYQGTAAAMIRTISGIASSVVLFQVCAYLTEKVFGYVPSRESFDTMATDIKERNSEALRKSMMYIILAGTLLNVLCYGALFATYKSDRGNVESTNKEHEEKAKPLPVSSSSPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1J2</accession>
    <name>A0A061D1J2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAJOR FACILITATOR SUPERFAMILY MEMBER protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0109640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766852.1">
        <property type="nucleotide sequence ID" value="XM_012911398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1J2"/>
    <dbReference type="GeneID" id="24563207"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109640"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="490" mass="53659" checksum="7FF433CD2F8D2184" modified="2014-09-03" version="1">MVGAGTQLAPAAPTEKVKYNAFGQFLFYLVSFIEGYDQQVLSMCMRAFELTLGFSQSQLSTLSTVSTMSRMGCCLIWGLLADNHHSNYVLGGGLLVMGMASIFLSSASHYKVILFLRFLHGFGFACVYPVQQKIVADSTGSEDSNQQAEEGQHDAADSAEEGEEEEDSKETKDANDMFTTFQALNCIGRLICAVITTLIARKVLLGYYGWRTSYVVLGYVWILFGIAIVCGMQGKFKKSKEELPELIKKAFEEVFQKKTTGISIFTIFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSGAGGVIIKEIAKKQKYYGEPGAGCVVMIIRYVVCLLFFLGPAPQGKLLWYHYVELAVLGATLVSVGGVDRAIMKKSIQDKYQATASAIIRTISGIASSVILYQISAYLTEKVFGYVPSRESFETMATDIKDRNSEALRKSMMYIILAGTTLNLVCYIAYFVTYSTDRIKKKKKAQASKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1L0</accession>
    <name>A0A061D1L0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-binding zinc finger CDGSH type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0103265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766193.1">
        <property type="nucleotide sequence ID" value="XM_012910739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1L0"/>
    <dbReference type="STRING" id="5866.A0A061D1L0"/>
    <dbReference type="GeneID" id="24562548"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103265"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103265"/>
    <dbReference type="OMA" id="CDGSHMW"/>
    <dbReference type="OrthoDB" id="15717at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="118" mass="13728" checksum="22A2B4EF76EF0582" modified="2014-09-03" version="1">MVWSNWWPHDPVPESKATDPYIVKVKPSQVYWWCSCGRSQRQPWCDGSHKGTQFKPVMYVPRHNATRLMCGCKYSYRKPFCDGSHMWVKAHRNVPKAAVAAFGFFFSVGVFTSWICHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Z6</accession>
    <name>A0A061D1Z6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766839.1">
        <property type="nucleotide sequence ID" value="XM_012911385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Z6"/>
    <dbReference type="GeneID" id="24563194"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109510"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="6502" checksum="10FB66794CFB088A" modified="2014-09-03" version="1">MRSVKPREDYDSVEDPQAQPGWMPAWMAPVTIGNGQTRNPQPVPARGGSLGKLNSSTSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2H3</accession>
    <name>A0A061D2H3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766473.1">
        <property type="nucleotide sequence ID" value="XM_012911019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2H3"/>
    <dbReference type="STRING" id="5866.A0A061D2H3"/>
    <dbReference type="GeneID" id="24562828"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105960"/>
    <dbReference type="OMA" id="HTSKHYL"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1230" mass="136534" checksum="E15D859C6AC1E2BA" modified="2014-09-03" version="1">MSQLSAPSPEHALVAELLSNSVAADARVREEAYARIVELESRPTFLATLIDVAYLGDAQISKLAFICAKNALARLRGFAAIRAASGVDVDSIDPALNNLMAKLLSVFEAHLKDETKVIGKDFALLVRKISRRYYPQNWIPMHDLLVRGVEAALSDAVTSTRTFNCIFLLYHIFKEKSTLRLMRDRNDVANLAEVLYPLVSRLWIKHWLERWSSGSLDASQFASVISNVDLELSRYLDSLLIILYTRGLRNVYQRTELLEILKLIWVKMKLHMFLLQSELSSNAQLQKNSRRLIRGFAEMLDKEPMIFAFVDPSLALNPIFDYLAVGTVDAVISQCMEVLCTAFKSPVVNNDRYMHQFYALHGESDGLRTLRKPREANFTVCATFDEMKSQCELAASCTKGGSVTSSFKKALSPMKGSYNAVGNVAENMSRQATFLFWECIYARGGVLQLLDFLRDKYLTLDPEAIAEWSEETVPLDSPPQAPAQPVIEAMKVTGLPILNWVAESIVGVDCRTNFPQLDSYLLLYSIAYPSIANYHTSKHYLTILGAFKKALSEFDAPMAKLLIYRCSGIVNAWAERVNLFEEQTKREILHYLVSCLCCEGDSIALINLRAQHVVPFHCLYSKTVDEPFWDVLRQGTNAQRIMASLATIAKLNAPVIQHRSIDLLCKMCLEFDTELNNFGHQLSDVLAVLSDGPGDLQLSASLLQTSLGFLNSIHWRRFYVEESTLNSHLLRFLFHLLFRTVVVGPATNDKATTSCQRLLSLCKYAELEEDLLMLWICLLRVLPRTVDTVDQEMLNNALSLFPLLIAYLADGDHGGAPGEMRVSSVSPIALDVVIDYLAVALDLSKFQLSGARPATGMADPSVGIYESSGEMWFQLRATASHSVAFSLYQLQQLSVETLKRPDGDPLRQGGLRLLSMLTCGFGTFCMSSANLLFHMHDILLQFLVTLNEAAILPENAPQEYQRSGVVCLKNGSGVESACMWQVATVSSEVANKVSSVIPVICRWGFDAPASFSEAVIRVLGSGRFSSMDAIILSLLHVSKKLVNNAYLRLGALVCCCLLVSTVASHYSGFNLFVLNREAHSQSNGSESDKDGFSNNPHSDVQGVYLPCYLLRLVHPVAPLYLDAKRAFCFSTMKAPLMEGGPTYVLPPSKRLHIFTNVSATYQSTNLPVFDLSPQELFLGALKSTISCIVSLSRTLSNRGVTRSAELMLADGARLHAKLREILEGCTNGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D326</accession>
    <name>A0A061D326_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0108000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="9"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766688.1">
        <property type="nucleotide sequence ID" value="XM_012911234.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D326"/>
    <dbReference type="GeneID" id="24563043"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108000"/>
    <dbReference type="OMA" id="IIIFPEE"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000050">
        <property type="entry name" value="Acid phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="933"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1301" mass="149278" checksum="73DBF82287F7B900" modified="2014-09-03" version="1">MNRIFTLGICAMANKVESAPMRSILHHLRATGDFEIIIFPEETILHLPVTEWPIVECLIAFYSTNFPLEKAIDYVRRYKPIVLNDVERQRVFKSRLEIYRELQLCHIPHPNYVVVDHEAVRMGKATFEENEDYIVYNNVKLKKPFIEKPVDADNHNNWIYYPTNTGGGCKKLFRKVHDRSSQYCADINTVRRDGTYIYEEFMSTFGTDIKVYTVGCMFAHAEARKSPTLDGKVNRNTDGKEVRYPVILTAKEKIIAYRIVEHFRQVVCGFDILRTINGPYVCDINGWSFVKHSRHHTDLSQIIRIMFLLKLQMKYNITLDKVIPARIITNETVEALKKTFVDIDQTIDRSESQEELCSVVVVMRHADRKPKQKVKIMTQHPLILGYFDGVTDKQINLKAPEDMRRFTAINKIILEELEGEMLMCNSPTYSDDSSDTENPQTRTLSERLTLHKEMGNMLNTSEGFAGINRKIQLKAKFDDEGKVQQVLVVAKWGGELTSVGQCQAEDLGRRFRQSLYPTDCTGLVRLHSTYRHDFKIFTSNEGRCQLTSAAFTKGILDLEGELTPILVAMTIRDKRAQMLLDDNIEVRERNQCKNRLSSLMENWGNKHEVDKLLRNMDADEAKYYRKALEKMNFQNEDMNRLNKLLNDFMNSLDHEITKWMYLYSVDEYATSVLEILQDMATRWKNLTAKLYKGPDCKFQYTMVADIVDNLRYDLIHHHTYLGSGLDTAFDIYNLVGPLSAILSPCEYGVTPRERLTIGMKVAGRLLQKIVHDVTLHKNSRDVTNNAVYQQRNRDQLYAKLVEQNAICHERRNSIHEGFDEYYGNKLPHERTSSEPSDFVPKSEKLDIQNMVHTNTGDPLKKISLIASTSASAASVAASSIALGSDGINCIPDHSRMTFIGGIKPNEMKYSCRTNMEEIWDLLTSGARLPEPVEINSGGTLTLSRTKSREHYSDDMDNTSSSDDSDIVRQEVSEARKMSSDRSHRMVRSRYYVTSASILFSLLNFLKYAHYLDDDADNSEPLVHYNTRDLHYLSHVVLRVWWSCKENGVPKYRVEILVSPGARDGFGQNYDILASNARSQKHKYRRHISRFNLDYVRGQVLCKHCGDVIDPAFVRAQFMDNIRVKSYQSGMRRSASTANLQYMTKNVKGAELEFDPKGAATDNAASRESARKGSWWYRCQRCAASNVSAIIRAASNVRSTRSSTASERSDSPVKSRSTSSSRDASFSPTFGFTDEQLKQHRSDNGAAVPPYCELSRLAIINYNCDINRLEQLVNKVSLFCSLCMWCFLWMFELNVVHKSYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D369</accession>
    <name>A0A061D369_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U4/U6 small nuclear ribonucleoprotein Prp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767239.1">
        <property type="nucleotide sequence ID" value="XM_012911785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D369"/>
    <dbReference type="STRING" id="5866.A0A061D369"/>
    <dbReference type="GeneID" id="24563594"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202100"/>
    <dbReference type="OMA" id="NPQHRFK"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="111"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="397"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="534" mass="61929" checksum="F99D532E374958CA" modified="2014-09-03" version="1">MNAKEALAAAKKEELVRQQIKEKLSKINITKKLLPTTTKLGIKPLTVDSLGRVLDETGNVMQHRPMMHSRLKINQNFESERMQKEAMTAANAAAPERQKLEKASKKAEQSQYVDPSLMTVKKRRRMALNFVEPGSYIRQERQLQRQMEDKAMGINHRSIQAHKKQLLEQQERRLAARQKIELAGERGVAIDEVTDNVEEMNPNLIPLKAGSRLDKKDSWDDDEPWLEWWDRGIIILKTGEDPFKTANAKKHQTLDVQPELCMINEKKFNNYIEHPCKIDGKKKRAKEAPAIMLTKQERKKLRRRKREEKLKKIQDKIRVGLIPPPPPKLKLSNLMRVLKDQSVADPSRVEKQVREQMEERLRNHERRNEERKLTPEQRSKKHAKKWQVGKNEEIEAALFTIKSLTDTKLLFKVDINAQQFHLTGCCIVASHGPSVVVVEGSKLSVKRYIKLLMRRIKWEESEAAAASDTPMPLGVPAGQFCKQIWTGSVKRRNFSHWSVAFAECDEEITEILRPFKAGHYYEMVQKYRDPLEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3J3</accession>
    <name>A0A061D3J3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767472.1">
        <property type="nucleotide sequence ID" value="XM_012912018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3J3"/>
    <dbReference type="GeneID" id="24563827"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204440"/>
    <dbReference type="OrthoDB" id="10312371at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="8204" checksum="0C75D46E6191395D" modified="2014-09-03" version="1">MARYIEANGHRCESDEDPPRSAESPAESRDFSDISASRNQTSVICTKINILKTKTQMAFSSLKERFQKKKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Y9</accession>
    <name>A0A061D3Y9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767627.1">
        <property type="nucleotide sequence ID" value="XM_012912173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Y9"/>
    <dbReference type="GeneID" id="24563982"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205990"/>
    <dbReference type="OMA" id="RRHEWRS"/>
    <dbReference type="OrthoDB" id="363204at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="8378" checksum="F99CEEA7E4C37D85" modified="2014-09-03" version="1">MTHDHVHKRTLSKDNLKSAAMIAGGYLIFSAAVWSVFANPRRHEWVDVLMDYCNHRRSQYSGIWARFSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D431</accession>
    <name>A0A061D431_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0206590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767687.1">
        <property type="nucleotide sequence ID" value="XM_012912233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D431"/>
    <dbReference type="STRING" id="5866.A0A061D431"/>
    <dbReference type="GeneID" id="24564042"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206590"/>
    <dbReference type="OMA" id="YYRGQHP"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF92">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="18410" checksum="C092CEBA1DE61D62" modified="2014-09-03" version="1">MEAKGGEITILEDELKKLQGITESEMAEDAMETEENEEVDRRSIYVGNVDYSTKPHDLQEFFKASGQINRITIMVDKWTGKPKGYAYIEFANEDAVNNALMLNDCVFKERIIKVTPKRKNIPGFGKKRAGHARGRGRGFRGGRGGRYPSHYRGSNRGGYGKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4E9</accession>
    <name>A0A061D4E9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S8 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0101330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765990.1">
        <property type="nucleotide sequence ID" value="XM_012910536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4E9"/>
    <dbReference type="STRING" id="5866.A0A061D4E9"/>
    <dbReference type="GeneID" id="24562345"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101330"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="14858" checksum="5D886ADE73975BB8" modified="2014-09-03" version="1">MVRMSVLADCLKTIVNAEKRGRRHVLIRPSSRVIVKFLLCMQKHGYIGEFHIADDHRSGKIVIELLGRINKCAVVSPRYDIALDDIEQWSSNILPSRQFGHLVLTTAYGIMDHEEARRKHTGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4P5</accession>
    <name>A0A061D4P5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767867.1">
        <property type="nucleotide sequence ID" value="XM_012912413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4P5"/>
    <dbReference type="STRING" id="5866.A0A061D4P5"/>
    <dbReference type="GeneID" id="24564222"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208350"/>
    <dbReference type="OMA" id="FNMEFCK"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1002" mass="114813" checksum="AC30B7BF92E91C76" modified="2014-09-03" version="1">MDPIDVDIDDRGDALDNNEEWNQQQQRKNDQQLHGQVSPARDGAANDNAVERGDGHTGKGGDEPMLGGNREVSPKSSKRKRSVSVDNAEGGEEPQGNAAGQKERGKQGQGREGRRRHKFRRTFNESDNRMPQGSEQRHPRHHSTWNPELGKAKRWDTAIITALDAYDNAKQDIIEAANILEEVNDTSKPAIATFERCVEAFPVKTAAYASVVGILKAKGKATLAEHIVQRVLHNLVSSISSGNRIAAIHNMRFLIGTHCAGFESCQTMQIIEALIKIAKNIEEAEFESHRKYVNAVVAADNLIYIVMASLPWFSRDEYTKHKKQIHAFCDEIAAYSDRRSYKMERVASDLKRADIDPSNDDHLHNPYAYIAAYNTYTDDIRIQDRLTTGVECLRSLREHDWINTTTFRFYQSKGIAEHIFVENAEHVVADEVAQVTQEILQAILQIEHDKTWNFKPVPFMPLKFEPLDEKHDKIKPHDRWIFDEHVIHTIHVFMDDTALCARQLIKIPFNHQYADCAIMEILFNMMLSPIYRQHFSMFAILVIHNLCNIEHKLEGVFHDLYSQLTDDIPRLDPAVVSDLLTVGAYWFSVEFCKVRRLPLAMKLYRSKHKADGSGMDVEDDRNDQADTEQVKEAIRMKNKNLFNVMFKYNIKSPLNFNERLLDKISRLVYMDRLLVFSPEDLKDSVRAAVQLPPPNVQHAFRDKPIEHKVFLNLFHFNKLTAEENELRNRRIEGFINNLVGKEPLKELPPNVFAENKIPDVEMTDEADAADPTVKRWSREELILIFWESLLIFGNKSLTHLMRLLEFHGEVLKRFVDNDREGAFQDSITFKALKLTQQTLKNTKKFELVTGELLKLNVISPADACRLVFHHFPSAEFFSNHSLCIMDTAFEVARERVEHARTRIGDSTGNPELQRVALEERENWMRQLTLTLLELANNFMAQRMGEQLDSSLASIVKNVLLKNATHSYALAYARNEAAERGFHRSLVAAVDLALLVQSIQTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4U8</accession>
    <name>A0A061D4U8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767779.1">
        <property type="nucleotide sequence ID" value="XM_012912325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4U8"/>
    <dbReference type="GeneID" id="24564134"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207480"/>
    <dbReference type="OMA" id="YSYFLEN"/>
    <dbReference type="OrthoDB" id="366299at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595464" evidence="2">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="284" mass="31250" checksum="6F62067D1FB6AD6F" modified="2014-09-03" version="1">MKTGVCSGVLALWLLSVADVYAIEESAGSGALAMQNEESTPYSYFLESELDNTYERGDDSSLYEIPDDDALTTMSLLDLAGAPDLLESADGEFSDESDFSFLEERDEEDEFNGESFLEADDDDMFDFDASFMEAEEDENPADELSSGIDEELEDAEATNTEFLDSEPTSYVPIRHRMTAKKCNNHLNNNVQPAVEGVQDAKAAMLQQDEVAETSSSGSFFKRNRAVIIVGVVLLISAAIGICTFKYPPPCVAAAKERIRGYFNRENDRNSVLPEVTETEPLVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4W2</accession>
    <name>A0A061D4W2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase-like protein 14 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0208900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767922.1">
        <property type="nucleotide sequence ID" value="XM_012912468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4W2"/>
    <dbReference type="STRING" id="5866.A0A061D4W2"/>
    <dbReference type="GeneID" id="24564277"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208900"/>
    <dbReference type="OMA" id="FNSELYQ"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="453" mass="51927" checksum="B0DA6DF072B8EDFE" modified="2014-09-03" version="1">MVDSDGKDGAGNLPPVLPFAPMMMNMMPGPMMPPFPMGVPFPAGMMPGAVPVGIKKRGRSRRKNDAFGRRTGDSTSGAKDHEEGRQDGKRGEKRSFISTRGRERIQNDYNQRFVETGERPQNFVRDVGEGKRFGEYPKLDRLSNLKREIITKRATPARHIRADLRTFDFDSLRVLFDVVLINPPWRTFKMREMNQNFGWTLEDLIEHVPVDKIVDAMSFCFIWCDSYTLDDARNALRHWGFRKCEDICWLKTNANWSSLDPYGDTTSKVRDLDSIHPPALLHKTTERCLVGLRGPVRRNEDDYFVHSNLDTDVIISEERDPRERLRMELELQLDEGENMQMQMDTYLTNLNPKPHEIFDIIDRFCLGRRKIELFGSDSSIRNGWVTVGPAVSTTNYNADEFLKWTSGSGCWPQIQDYRGGRLMGTSEEIENLRPKSPAKLSGKDASELRDAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D540</accession>
    <name>A0A061D540_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767869.1">
        <property type="nucleotide sequence ID" value="XM_012912415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564224"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208370"/>
    <dbReference type="OMA" id="YMALCAG"/>
    <dbReference type="OrthoDB" id="361597at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1563"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1643" mass="175433" checksum="6BAA2206BB170BB0" modified="2014-09-03" version="1">MLDSESVLELRRPSVADGGESSVGLPGLSRSSAAARLEMVSRDAGHAPSPHSAHASPTSEMSSREPKMCAYALSDSPDKVRTAKSQRTQSTAYSVSEAAPAARPVKRSVSVDGEPAGVMSEDSTHTERGKTDRVHVPGAPRRGVVDVMTAPTASTMPGILPARYAMSKMSTAACSLTPEEALKMLSECDRSTSPSSSSIGDSRSASQADGAPANTAVAASHRPIEVKHAPNSGKGTFDDDLLNFLRSQTIQSLQASRAHPFDDVAGLNTRVDLSRVASGAVPPPRREPFIPDHDRLRKNSPRVPSQSQPSVFAAGARSAAKPVHSPHAVRREPDYASHFQEDDSVFSQLRTVFAKVKSQDSDLPSACAERAADGLSDDVHGVSPLLEWFPEEPSLPISPSDPAACDDNQTSLFKDCHDVSEYDEFGDPFFVAEIPDGKNDINNRIRMLRRVHESLYTTSDMASLGTIEKFMLELMQPDSDFGKLTAYGRLLAFINLSVLRRFISQLSALYRHPEMAVVRQVMRCNEEGSIKKVLNISESVASGQLTDKAGLAAIADLMSRLDRNEFYGSDRGSGYGKAFDSSSSSYVSSKSGSGSSSISMQTSRQLLAVLDDLSGLYLPGGEPHFPRYVCGGVDRKCVDVSDTLSIPFDKGDRRTLHVQFERVSPSYRGYWPGTTLIPQTITEGMRIQVLPTKQQTVMHWILGRVTSISSGVLMVAVDNMAPKEVGRGSSADRMYMLRNFVPPNVPTSRLEKAQWRLLPRAFDPDRDIYVGSCLSVFDPAIGGYTDRVVVNVLFGDDYDCGIAPVKSPADDTLFGKPPSPAPPSSQSNATHAKSSADGSDPATLTTQADSEASARGAGAPTATTAEDDTIPLDGVTSLPGYEGGNISANLHVAPTSRIKVDPNGKSNQAAVHNADKFESISATTSDFPTNASEPTNSKNVSKPNRCAVAVAAPAPAGSIPTCHCNGHTLRVFEGRAATKFIRRPKRVVLSSLYDRRDVVVNVEGLRAYKLNYDLQSHFDSQPEHLAGSTGTQAAGAPAGQFQHCVWVVPRNLPFSDAPNEAVSVGKTGSQWFFKPQRCLMMLPYSKSIDVLQEAPRVVSFLHPELNYMALCAGIWSVRGAGRGVGELNQAQAESGHSTESTTGRSEPISLTRSQKAATRELTANDIVNEACSGVVRCHLSLLRRLFGCTAVISLWIALEGVDLDNVTTGNLTLSIVIPPKPACASCGGAVYARDDMMKILPQDPPLMLPQAGKDSAAANGGAAEAGAKVAAPGNAAAETAKVGGEAATQAAAAPNAAPNTNVASQNHAGPTVPNVAAKAPAAPATETQATPASGTSTRVAGRPVITGSAVRPDVAGHAREMPIFNDLETTEEVIRRFQSLATGRWRLTRDCIASYTVDDDVLPAPVRNQQNALTSPASRVYGGKSEFINKLAQFLTSARRARETKIDDSLYRGAYSTAREHFNPRSIESVLLRGWGTFILGQSANLAAHKATSAGRGAASGSKNVNAARASAAAAHQHPRPMPGVTDPKAVGKLDPAMRHLAAAGRAEAGVPGASNTAQRRKPREEKRPRPARGESPREDRPSPADPREPADRSKKPRRTTKLSRMADNEYCEFNDKEIRYKLVSVVKWDEDLEPSAVVSGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5L5</accession>
    <name>A0A061D5L5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0209860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768019.1">
        <property type="nucleotide sequence ID" value="XM_012912565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5L5"/>
    <dbReference type="STRING" id="5866.A0A061D5L5"/>
    <dbReference type="GeneID" id="24564374"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209860"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="535" mass="58047" checksum="07DD4F293678204F" modified="2014-09-03" version="1">MSKVAAEAPAPAAKSGVWNRNEKQTDVRKQNIIAARAVADMIRTSMGPRGMDKMIQDGKAGVVVTNDGATILKELRLAHPTAKMMVELSKSQDVEAGDGTTTVIVVCGALLEMADNLLNQGIHPQTVANSFKMAVEKCEELMEEIAQPISLDDKETLTNIAAISLHSKVVSTNASLLAPIAVDSVLAVMDEKDSTNVDLNNIRVVKSIGGTVEDTEMVNGLVLTQQKIIRVASGPTRVVNAKVGLIQFCLSPPKTDMENTIVVKDYQSIDRIMREERLITARMVKQIAATGCNVLLIQKSILRDAVTDLSLDYLAKAKIMVIKDIEREDIEFITRAIGCEEVASLDHFTKEKLGTAELVESEFEGGQQIVKITGVNMKKTASVLVRASNSLMLDEAERSLHDALCVVRCLVKKRAIVAGGGATEMALSQRLGAWARTLHGVEQVCIKAFAEALEVVPYTLAENAGLHPLKVITELRNRHLEEGGTKFGINSKKGAVSNMMDDKVIQPMLVTLSALKLATETVMMILKIDDIVLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5P3</accession>
    <name>A0A061D5P3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767503.1">
        <property type="nucleotide sequence ID" value="XM_012912049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5P3"/>
    <dbReference type="STRING" id="5866.A0A061D5P3"/>
    <dbReference type="GeneID" id="24563858"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204750"/>
    <dbReference type="OrthoDB" id="366090at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="405" mass="45975" checksum="877F688FF3ABCF25" modified="2014-09-03" version="1">MTRFDIPYCSVCYDYLTSGLCVLTKCGHVYHRKWSHIAFKNIVELKFECVERADENEDKAIEDVNGVHTENAAENTGNQVSLSQYEATKQELEDLKRRLSKAAADMLELQERCASAEVSHRILRISGDQNKSPRRIGGSRAVRCYTWVVTPRTLDTCLRTTVTNDPLITFPSTTADLVQNENTSIREAVLRMQEDNAALIGENKNLRVIAAAHKTSIAKLNELLAKNKAKLKKLEEVHNYLKADEIGIQAFESCLKTLSSSEKLALLTNRIMELEGINKTLTDMKDVWKKKCDEISGDYLVLEREYKALLMRSSSEHQEPTWDPFSEVESSIASVRALEAEHEYNRRIPRSINVARIGSSRSREVNTGSPQRRVRVEVFESPSERAPTRSGRTRTQKISDYFRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5P8</accession>
    <name>A0A061D5P8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0210260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768059.1">
        <property type="nucleotide sequence ID" value="XM_012912605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5P8"/>
    <dbReference type="GeneID" id="24564414"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210260"/>
    <dbReference type="OMA" id="MHHNRAH"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="497" mass="54078" checksum="8464DA2BC93D8D8C" modified="2014-09-03" version="1">MTQGAQAPPTQTQTPKLKYGALGQALYCLVSFIEGYDQQVLSMCMRAFELTLGFSQTQLSTLSTVSTMSRMGCCLIWGLLADTYSSNYVLGGGLLVMGMASIFLSSASHYKVILFLRFLHGFGFACVYPVQQKIVADSTGSKGVEEHSKKADGTPNQGKKAEGAQDQAKKDEESEAKSMFTIFQALNCIGRLLCAVITTLIARKVLLGYYGWRTSYVVLGYVWILFGTSIIFGMTSQPNNAIAKSGDFKTLLKDAFTEPFQRATTWLLIFTLFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAITLIGGAAGSGAGGEIIKKIAKLNKEGYGELGSGIAVMVVRLVVSLLFFLGKPPCGKLLWYHYIELATLGGTLVTIGGVDRALLKDAIEKKFQATASAVVRTISGISSSVILFQVCAYLTEKVFGYVPSRESFETMATEIKDKNAEALRKSMMYIILAGTALNVFCYIALFFTYKDDKEKAEKANTPTSEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5V2</accession>
    <name>A0A061D5V2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768282.1">
        <property type="nucleotide sequence ID" value="XM_012912828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564637"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2050"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2112" mass="236052" checksum="6FAFF00D2BA58707" modified="2014-09-03" version="1">MTSINFYNNLSLVTLHFPSSTSCHCPDHVHPNSKSAELPCLINAMTSINLYNNLLILTILLLMMLLEEPCRTLTPSSLALVTLLDSLADLLVRVRVLRKPLRMLLSLSVNSAGLSVDTRKISELSQRVTQEINDINQRINSPNNLNNLPSSPSPSAELDKLQSKLQALKEVEELCGFLTNRNNASNEPKKLLENLCSGLETFLGFHPSSKGYDGTGIVYSDLDRLCDAVMGFLSGVLSAVKDDEAVKTYDNYMAKKLSEVLKEVNNNIGSGRTGLVASVGAVKGWLDNYLLESGTRTSRVTGNLGRLKDEIAGTYTNNVAGNADQKLETQLTRWTETLQSIELDVNNTENQYVNLLDHKLKNTLLHETNVIMKSVQVLQKSAGNAEFKRKVQAVDEELKWQKEKLDASVKDETAKVQKTLQNEFENIFNEIRRLTHCKWEHFKTLRPNVIAAKENLVNLNVEFKTQIIVALSDIKGRLDVLDRSKTYVGAETGKSKLQVDVVNIRRELGSISDTLEKYEYALSAWMKDANKLIEKAINVAGDILNKEPGRVIRETMEGKAGQLKNWKDEIGRYLESVKTEIKQKVEAANRLVAPLEKVYKKKLVDIKKAVLSTVGDHDDSKEGSDGKYTVLGLLNKLDDHVKTGLIAARDEMNKKLKTYIENELPGEVQKVLDELVKPIYEMRSSEHAGELGLFVKNVSTYAGQFKATFEQKIEDMVTAIVNDQKGVIKSYLNWYVDRCHRCFNKSGFNGNPSDIVTKLTPIISVQVKKLIQTPLTQTIGDVHIVLGSIGTYLAGVADAVDARKVFTVVKGIEDALEVREQDKTASPYKSNQKYLTMSLQTILTAMYQAVKGAADRLQTFIAQSQISALHTAIGKVQQLGSDVKRELGTGGNAVSSSSNGANFSKTVAAAIDSSLKQVITGNGTDISGIDFKEKTGVDAGLMSDYLKQTQKGAAKNDDTLRGKIENIKKHFDDIKRDSEYGPITINGIEHEANNELKSAITGITTYADAINVEYIKNALDTLSTESTDNLNEITKAFSDAGSFVRDKLNTLRTYKIDDYLNKTMEDIKALRTTELNNVITTSIKSILVVIDSLEQTPQFIDEKRQHVEDVMDKLKNEIGDKLDAIDSALNEADKYIQSGIDDVENTVRGAKKHAVEAIENLKHNLLCMTEYSFKSVTAQVRSLFAESHRADLSALKTLLSTQLKIITCTINKNLNTGLKGFLKTLSGDSIDLYAAGHDMDRRVKKPSTRNLLDEVKTAIDGAQQHGEKVKSLSSTFNHYSEHIFTYLLKDMAKHFTSQPDVNGAYTTNVTAIQHHLTALLDHISAHKHFDHQVPGKLETLKTSLTTFTSSHFGNASYPVLDAFPQSLVRFVGELERVYVSRYEGEVFTDTLMKKKKDSDEEEKITDYGTKLSKVCLSMISIINSDITLLNSKCDYPCQKDKINEYTELGGIMRKCGFGVSTTATKQDGELRNKDECTGSHILEKLGRVTASATNNTNLIHKLDSLNQHLHDYYRLCHIMYPSKRQPSSVYEMLVWLSGLRCNPVYDELLLNGLSVPFEDPEKETKEAGEDFEFTVVDPQSLYLNAYPKEISYNHVVASLEYICSNAYDLLSTILGTGNTYTLYSVDYCTNALNLRYPSVADDCLHSILDILRRMFPVLRFMHVQCMIGAAQHGWSDCRYGKDIPSAKRPCIDHLTDKEKNQLDCLPTYSASGQPTCQPNCQPNSPLMSYLNDCLPGHLPHQLTDIGCKAKCSTCPKSTPGMPCLTPLGFRGFSGTSKTGKEICNALDKFFDDIHLSSLFSLVPKPPSTLPEHFNFALSLVTCLNSTTHVDNKRRLTFGDKFGATIIDTSINLYDQSTKLTEALRNAYGIVQSSHTGDHSSYELTPLSSLSMKKSCVYPNRNVHCGPYIQSLWNDSYTYLAEKHADHYLSWALYLPWTLYDYLRRLLQDFQNISCRDWGCSRCQHGGKCMPGKHGVDYNCKCRSLVGCRGVQSTFYRYGFTFGNSMTLLESNGIRYCRDFSNQLTNVLNSEYFKTLFEKCDEFIFTIRQPFIWLNVALWSLSLFYLICVMLGRLDVLHIKSHLRIPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D623</accession>
    <name>A0A061D623_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767653.1">
        <property type="nucleotide sequence ID" value="XM_012912199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D623"/>
    <dbReference type="STRING" id="5866.A0A061D623"/>
    <dbReference type="GeneID" id="24564008"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206250"/>
    <dbReference type="OrthoDB" id="366993at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596006" evidence="2">
        <location>
            <begin position="21"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="646" mass="68940" checksum="E66229D4AA794701" modified="2014-09-03" version="1">MKFVISLALLVFNQIHLIAAWETDSRHAGSKYGSVAAPNSRNMMSRTRKGFRVVTDIREMDGWHPELLSQRDMAFKNAFDDVLGRFTSNVIRTPYVRKAPAVAKPPVECTPDDVTVSDDTTASGVISTPDDVTVSDDTTASGVISTPDDVTISDDTTVTIDVPTPDIIETPDDLTISDDLTISDDLTTSDDLTTSDDTTCPNAIAIPYPEYGDRMNPDYETVSRPATNDDVQKTLDYLKGRIAEGAKRSVKPKPEYTETEQESEGSDGFFSSLFCCGSGKKNAKQPKPVVIGLEGEPVRGVDGEPIDLPDNEELLDGNDDYDFDDIEDGDFDIDESQFFDGTPRTDGSNKIDDDADSGAVEGETIGDVADDQGYTDFDGEELEDADGVEVLDASEKIAVDADMETIDGIDGETVGDVVDTEVIDGEESVSNELSAADEEIGQVDGETGDADLTEAADAEKDYSSDHGEASTSDVDGSRASDVDSGAVDGNGLEVTEGDENDTFDLGESLPSLADEDQMKPTVSTSCATEAKPTKKQGGFGQFFANLFCCGSSKTHANDEEQITASVSKTVESSLRGIEEDDAPENAVSEADQSTVSEAEESAVSEVDDSAVSEADQSAVSEAEESAISEGGDDDEENEDEEEEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D640</accession>
    <name>A0A061D640_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767668.1">
        <property type="nucleotide sequence ID" value="XM_012912214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D640"/>
    <dbReference type="GeneID" id="24564023"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206400"/>
    <dbReference type="OMA" id="CASWANE"/>
    <dbReference type="OrthoDB" id="364048at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="392" mass="44390" checksum="6BC8FB70204ECC91" modified="2014-09-03" version="1">MSQASDLKARLVELRDQLRSISSTYSALCLYLREVDTLSALVASDYYELQRPSEEMTQRLDEWRSLERRIFYALDRHSRSNFESYRKTEAQFLKRLEKSGEGVPTKRDTGIRLKVHRFKEGVIAMKYATEARRRATNIADFIVAVKKQSGRDVSDHYDNLIILQALTEWTKDVIRDCVRCTASSADKFTNEESNGQIVYTNDVIRNILEFCDQHTAVDGSAKKCVGTQIVEYMLDRSPAARKDSAGPAVTTGSSDSSHITYYLFNLLRDLDSGHPVAVRRLEQFRSACKKQGVVLSIPRQIHVYQLHEYFYNFSKSSNFVSLIHATQQTALQTVSASFAADLLRRILAVVEDGDFAKLDAVSILTAIRAAKFLTTPGDKKLLGIWSSPPFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D667</accession>
    <name>A0A061D667_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766605.1">
        <property type="nucleotide sequence ID" value="XM_012911151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D667"/>
    <dbReference type="GeneID" id="24562960"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107280"/>
    <dbReference type="OrthoDB" id="10312282at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="27830" checksum="7EA0CCD369C27CD9" modified="2014-09-03" version="1">MVYKSLTNVPRNFKEAIDWLVALKGTDSEKNLAAIGVALYYFLADMPVGYTNLPALEKVKLVSKKFLEKPELKNQPFVKALLDRFSNPMNKTGLFARRSQTYTNSEYENVVQTRGAKCETLAKNFGKVVDATEKFLASITNPGEYKSAYSSEASWDDSCAKDPEACAVVFVGIAPMLYTGLHSLRIASKATTNKLLFDVKHTLGDVMKAVGYKEPGLRASISGSDVLKALEGVDKRVLDIIYDFSGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6F3</accession>
    <name>A0A061D6F3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Diphthamide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0108120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766700.1">
        <property type="nucleotide sequence ID" value="XM_012911246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6F3"/>
    <dbReference type="STRING" id="5866.A0A061D6F3"/>
    <dbReference type="GeneID" id="24563055"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108120"/>
    <dbReference type="OMA" id="TSNSRPM"/>
    <dbReference type="OrthoDB" id="361972at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="429" mass="47796" checksum="06DE3EA961B3B733" modified="2014-09-03" version="1">MDTFYVDLIASEIEKSGYKRIAIQSADLSVGSQFCHAIQARFRSSTERPEFYVLGDVFIDFVVHIGVSCHSVMDPPMPVRRVFDRSAADGGKLCLYLRDVLAACSYTRLILVYDSSMHHLVDAFEECLNSSGKLSFIAECVERSGGNSDRPESDDYFCGRRLFVCTADGQRTQASSVEASVGDSETLVLYVADGPDRDVTTDYLALSSVGSQFHVITVDSNEFSHRVIDERGHRLRMRRYQKVEKVREASTVGILVIARTLRGSSALRHSLSQLLESHGKRCYTFSVNCLTEAKLANFPNIDVFCLLSCGESVLSLPEELARRVVLPFEVLVALERIEWSAPYEFDFARLLPHAQVEEADALPASGGEIRRLRGNFELRTQVESFMGTLQDNSKRTFGGVDPLHGMSDQVTVVSGFHGTASGYEHERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6G8</accession>
    <name>A0A061D6G8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0301800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768462.1">
        <property type="nucleotide sequence ID" value="XM_012913008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6G8"/>
    <dbReference type="GeneID" id="24564817"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301800"/>
    <dbReference type="OMA" id="FFSDGEC"/>
    <dbReference type="OrthoDB" id="365572at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="186" mass="21078" checksum="ABB74C06BBDA5418" modified="2014-09-03" version="1">MARKVQAPAQKGSGDTPQLSDLYCTQEISKILHGVTLEELTKLGFKEDVFVSYTRIVLYLLLCGIGAYSGAFITVEKNKHLLKVAVGAFFTLLTFTMFYDKVVLRGTAYRLLVTDNLKVYIWCGVNWCEGTYDIKYAFSDSPKHIATYRVPLSETFFEDGKLDEEWYHNSMVRLSNEIKAASKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6R3</accession>
    <name>A0A061D6R3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767888.1">
        <property type="nucleotide sequence ID" value="XM_012912434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6R3"/>
    <dbReference type="GeneID" id="24564243"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208560"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="65" mass="7159" checksum="64759EE963B5E963" modified="2014-09-03" version="1">MGIPCNLENTARSLLTSATALWGKTMELPIRPINGKITSIIDAVMIDQLVQIRAPMFTNFAIIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D709</accession>
    <name>A0A061D709_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0110120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766900.1">
        <property type="nucleotide sequence ID" value="XM_012911446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D709"/>
    <dbReference type="GeneID" id="24563255"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110120"/>
    <dbReference type="OrthoDB" id="364732at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028078">
        <property type="entry name" value="ACDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14733">
        <property type="entry name" value="ACDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="364"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="AP2-coincident C-terminal" evidence="8">
        <location>
            <begin position="545"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="74612" checksum="4C9D601CCB0641F2" modified="2014-09-03" version="1">MRDNATPHGGEIHTANYGREHFVPDPMIMTRSSEEQPGAMLMPPFAMMPEDVKGSPQMPYDLEMQQAYKHYCMAMAASAAAQRYNLGATLGYESLPLSAWSREQFGEHMMLMKQQEAAAMQQARPWAPMSAKRTFNDMNMREGYGTTGARMASMSHAQERSDAQKRRAMAEIHMQQRQKHFNTFMPCDPHQVATFVGQVVPASGHRANVNSAAYGEDGERSAKAMQGGVALNETVIVAPQAPMCRMETRLISTDEGSQLSTVPSDAESEFEFNQSSAVQTRKKAVHRASYALTRCDSTLTGTAADNEYDWKRYKPNESSQEEDKLGFSQTLSGNLKQDYINFTKHGVLSNELRQEYIRRSKLYPKVRGVWFNSTVRRMGWVGQAYKKCKRIEKIFSISKHGFDGARELAIAFRNSQKPTGGASAVTEDTMLPIDTTYSAVTNDDFAVAETVDPVKTRDAAELYETDEEVTQRTEEFAEQTTEYADAIAQQQGFDRPGKPLSREDLESNGNHTDEEQEERANEEANATGIQESMFDQYKSKLTEEQREHRDHLCKGALRLMLYELAALVELDVPIPRLGREACCRGLKYHINALEACKSASDMLPYTAIFGSYICRGITPVDIPFGELYTMLQALSFCRPLGGTFDSAISTPFVGETDDANLSDLIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D730</accession>
    <name>A0A061D730_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ESF1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768504.1">
        <property type="nucleotide sequence ID" value="XM_012913050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D730"/>
    <dbReference type="STRING" id="5866.A0A061D730"/>
    <dbReference type="GeneID" id="24564859"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302220"/>
    <dbReference type="OMA" id="CDWDNIN"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="2">
        <location>
            <begin position="96"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="942" mass="106117" checksum="E4D29C3A49E2EB5E" modified="2014-09-03" version="1">MEQDERFVPTVRFKRAPKEVKPRSDARFARLFESDEGPRKGGHKIDPFGRPLGDAYDEDVSSSDDESEESVEQLAADSTTEAEEKKDDIEYGEASNRLAVVGCDWDNINASDLFVLFETMYRSITSNHTGCVRRAAVYLSDFGKERLEHENLHGPSLQSSEDLRDEELDETARQEALRKYQAERARYYYGIVEFESEEQAKLLYDEMDGIEADFAFSGLDLRFVPSEIAFEREPTSECFEIPSNYEPPLASTSAFRHSRVECKWDMPSMKRFKTLTKKFKEQDIESLELQEYLASDDDEVDVSKYKSLLTDKPEPSEPVKTEDGRVKTKVGKYTISFGAPEGIPDLAEIDLVSKKTRKTKTKSKRDRESADLEADDVRDFDARKPQEQQPGFQGEFEDRRFNRVLKDPDFAIDTRHPKYRVRACAFCNDVVSEHGFQQESAAQEVGVKTFAMSLNFDTSLLRRFLLAGGDGTAAEELLRNVSVEEIVLGLSQLGDECFPGSYDEESDVASSASDQYLGILLVRTLDKLLTKHRTVTLLQNQQVAELLSQRIPSSAYPVRRLFASKCELYFSETGVGSEFLEDVLWRLLLDPEYRIFEHCSRAICAVNNNSRHITASQLLRRRPGFLDDKRLETIRGAMCNADSDSIISVRMAEFCAYIGGASDAVFKTLLDAGLCRALLDLYMSADSLVKLNILELLDRSSVFVSRLLASNTITHDFIAYAISVTTDEGDSYDNVLLAPYLLRMMLSMLPHENILTSEDCKSLSRAVSGVIMEGNAQKASPLFLCAVQNFGALYLLGHMSAEVCRNLEGKVNSTVDDRVVSSAVATLDVMCEADLESDRFAFLRDMTRCVVAALSRFPFSDVRETAYRYLLKAIKFDEVARDLLDHESKTRLFSSEENLHANTVAKKQLTRQLVKRFDELSSGSASPMGDGGIAMLRKYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7B7</accession>
    <name>A0A061D7B7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768053.1">
        <property type="nucleotide sequence ID" value="XM_012912599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7B7"/>
    <dbReference type="GeneID" id="24564408"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210200"/>
    <dbReference type="OrthoDB" id="354856at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="215" mass="24246" checksum="E4E88E8C871BCA2A" modified="2014-09-03" version="1">MGSRTAMLAVRAMTRRLPSDLASTVVGIWPQKPASTSSDMPKHAIMGWNSGTTHPISPIRSPPVLCNAAGTAQWSALQDPFVRLSDGVFTHISQIECPVPIHVNLELPNGPRPETRRQPVQLPAVTTDSHHVVEDQQTGVYHIYDVGPAYLFNKVRTDTKHRKRAFTKRGYFRQSRSITRKENRMKFAYALQGIDYEMLEGLKRGEIPDIRAYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N9</accession>
    <name>A0A061D7N9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0211510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768193.1">
        <property type="nucleotide sequence ID" value="XM_012912739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7N9"/>
    <dbReference type="STRING" id="5866.A0A061D7N9"/>
    <dbReference type="GeneID" id="24564548"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211510"/>
    <dbReference type="OMA" id="CGRIAEC"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF16">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="734"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="770"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="805"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="875"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="946"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118208" checksum="BB06AC5C475E9948" modified="2014-09-03" version="1">MAREVFDSRGFSSARSGRSLFGEEKPRPFGRPARSEATEDLSTADDLIFTRLKTIFRGPVSCVDRDLNFENAFSRSLSDPEDPLVRGLYAGDMSGTCNTSLTSFDMSSCGVMAGVDSVSKLGFGESVMCLDSLAQALAADSASYADKEKAATQTETPLTHLASIETVATQDVLTPLGAGSVELGCDFADRVGKLLGRCMDGDEMAQKELATLCANEFNLPDAVLSPASVSALLRFCMLKGQLYFAGQLLQVAWHSRLYLAPSDQSQVLLSLCSSEAVGLLRSLLAKLPLDVPESEEVMSLFVKGVIKASRDSTSEALSNFASVLVDCGPDALGERAIRLVELFFREVDDASYSMDIVGTVQRICALDVFNEVSTACRFQACRLLCCGQPSEKADGCIKSILEGEGANVSFMEYVVKHETASYVTVVSRLIAMNAIGALDFLCALSLGHHLSQSGATVLKICLAAQQNLRSIVPEELCMPEFGDFEFLSCVGVNSFIQQIGPNIPSTMLGVCTAVSGIGKEVFTPLVETCLLVTDHAAAESVIRYMNEYYGHIPSTLVVSCLKIHLLRGNFRYVLERLVKKDRLGSIFRDRMNRTVCAGVAEFGLRVAISVLNFDIGFEFLRHCDTMDRISEELSELLQLLPPHLHSRSKVDEFVTLCERLNLDENAFSVALDCCLRLKNSKRLLRLINKFRRMGLQPQLQTCGVIIKSLACCGRIAECREIWQEMTANGSHEPNEVTYGIMLDAYVSNNRMDEAMALLHEMKHRGNVRPNTIMYTTLIKGFGQNRQLSRAMSIYDMMVSEGVARNTVTYNSIIDACARVGDMKSAAALLEEMMMNQIEPDLITFSTIIKGYCVQCNMDQSFQLLSIMYERGIKPDGILYNSLLEGCVKSGRLWLCEKLWEQMRLHGIAPSNFTLTILIKMYGRSGQLDKVFDLVGRLPVEYGFTINAHVYTCLMSACITNGRYSTALDIYRCVKDGSIKPDAKTYETLIQGVIRGNLYAEAADLLRDMYHLDGSMSEIGSDLAVLQKINTRVLENLFHKLQHVRLDEDVASTYRALSRRLQSMGVNVHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R1</accession>
    <name>A0A061D7R1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor E4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0100840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765941.1">
        <property type="nucleotide sequence ID" value="XM_012910487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7R1"/>
    <dbReference type="STRING" id="5866.A0A061D7R1"/>
    <dbReference type="GeneID" id="24562296"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100840"/>
    <dbReference type="OMA" id="WVIWEQI"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="242" mass="27775" checksum="F6E698F2938DF21E" modified="2014-09-03" version="1">MAEIAASVSGDAPEGDGAYPHLTFNKRFDDYHRLSNLFETCNIDVTAPLPLKNKWVIWEQIVKNHDQRHNTDYKCHTRPLVSFDSVQSFWNLWFSIPQPSELSTSQRLYRECTDGSQHIVDAIMIFRDGIEPMWEDTMNKDGGHFDYRFKPGEVGQFVVDEFWNNIILGLIGGDMPHAHLINGVRLVDKLATRFPVVRIEVWFQNLGEDNDATQLMKSIGNCMARRLDGTIGNVPKGDLKWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S9</accession>
    <name>A0A061D7S9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768927.1">
        <property type="nucleotide sequence ID" value="XM_012913473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7S9"/>
    <dbReference type="GeneID" id="24565282"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306450"/>
    <dbReference type="OrthoDB" id="10401213at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="120" mass="13540" checksum="651E015C68732EB0" modified="2014-09-03" version="1">MTGSIRAFYYTCRACNREISHKIAINLIAEKSLPKVTTAAASTKSDAPNSNKSDANSHLEDTLRARLQQQLSGPTSGWMMKQHKVNLSDNFRRIVNMMNSSRLPCPHCHSRGHWIWRGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D828</accession>
    <name>A0A061D828_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768884.1">
        <property type="nucleotide sequence ID" value="XM_012913430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D828"/>
    <dbReference type="GeneID" id="24565239"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306020"/>
    <dbReference type="OMA" id="TEATTQC"/>
    <dbReference type="OrthoDB" id="365828at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="290" mass="33070" checksum="BA0C9961B3F6A340" modified="2014-09-03" version="1">MELRMSPREFCRARSYPSENELSSGQHGWSTSECSSSTCDTSGSRSHSNNFRYCGARSSPFSSLKRSTRPKAQQQTETKVTVICANCDALRMQLTEATTQCYDQWISRIKVLEDMLQEKQKINDELQAACLEQRQLFEEGQRRIALLQREAEADTQVALNLKNQNYQLSDAIRQKDDLIEELCAEIKQLQEKNRHNAKLQELDRHTIDKLRRMVAAKGVQHKGSSSSAKLNRKVHRRETIAQRTRHQLKRRRRMKGLSGTVGPLILLPADNATSWETDVAGAFVTSGMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D839</accession>
    <name>A0A061D839_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COPI associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766071.1">
        <property type="nucleotide sequence ID" value="XM_012910617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D839"/>
    <dbReference type="GeneID" id="24562426"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102140"/>
    <dbReference type="OMA" id="AKHRIMI"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31321" checksum="5E91C6A107A92BC4" modified="2014-09-03" version="1">MDSHKVDPVDMSYGYTEAPGRQPYDMERASTQRSLMPLSDHMDTGAARLEQTLEMLNVRYQSLFFASAACIVANAVMTFLSSFGITQLPCLIMSVFLIINGLMIMILDVPGTPRWAGKHRRNIRKNMRFLTRLTGKSLWLALLGATSLMTTKATRSVNIFRIFMSTVSTIFVFAAAGTGMLIAIRKSLRLERVKGIIKENSKGAYIDCYRKYALGDPDYGMQFQEFNRMCADHTSGTHQFDIVDLYIIFNVLDEFQKSAINEREFYEWMAGSLVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D841</accession>
    <name>A0A061D841_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768894.1">
        <property type="nucleotide sequence ID" value="XM_012913440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D841"/>
    <dbReference type="GeneID" id="24565249"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306120"/>
    <dbReference type="OrthoDB" id="365216at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="207" mass="22403" checksum="8D068663E8A212C4" modified="2014-09-03" version="1">MKTAEAIPAGQRLEELSQEHDLSSLPLCRTLLPGDSAALSYCLNGSTCRIGTGQGGYAQVVCDCSEIATSDYFFAGPQCATKVARMYRIQQARNLDSTVQVVNTSFFEDVLGMNQWKNDVNSSATDQISELIAANTSAGVSTPISARSREYSAILSRVARITATFSDTNMLTRLCSEPSYTWDKVPQLCLLTSALASSERSVFNSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D873</accession>
    <name>A0A061D873_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766111.1">
        <property type="nucleotide sequence ID" value="XM_012910657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D873"/>
    <dbReference type="GeneID" id="24562466"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102540"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="29905" checksum="F563BDCBDFFDA32B" modified="2014-09-03" version="1">MESDRQDNNTPPLDNTVLLEANVPVVYPDMPIFNVLTQTQKILLLILVRLQIMNPRWASYSENFLVHYRNLTSSGPSVRRKPYARAFRDLHEMYRRLDPIIMTAARKMSPRDMQWISEIVAESYRLLDILRIGEEPTFVPMQLTAIIDGLSVNPPRHMFHHLRGCMHDMAYFNVRRGSIEGMIRFRNARNEICWSRVHELIRDGSLSFVPAIYYTRLNSPLQFRNGSLRASIGNNCPPLHCKFHQLYYTFPPSNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D879</accession>
    <name>A0A061D879_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769072.1">
        <property type="nucleotide sequence ID" value="XM_012913618.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D879"/>
    <dbReference type="GeneID" id="24565427"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307900"/>
    <dbReference type="OrthoDB" id="367203at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1442"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="648"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1442"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1458"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1722" mass="190468" checksum="173D03AFDB5A21EA" modified="2014-09-03" version="1">MAKSNVPTFKTLKECLEFLQWLHTDKGMQYRVTRRLVRLLEKKYITYNTKDVESALSTFLRSVSTFHEKLCNRAGQGNYNLGKATHALYALLQCIPKFLSVMYFMRYQVDEKFGAVGGGGWKNDWTGWGALGPNFESRGGELDKYLYERAGEAYGVIPGGFDKGGKEVKYRGGYFQGRDMASDLINICDKKIGQLFRDVFVTSVLSKTSGVDVSNVANALRVVRDFCGIFEDSTNEEEFKSHVQSRDKCINWNELKKHCLTLKEKISKLFTDNRFSFTGYGRKYEFFDKSIDKRMASWLKKNLSGMKNNLEKIKPFSGVIRFNSRTFQKGKPLPPGYTEAFKMYFTDNFFRYGFTFFGNTYDTRNAPYDVLQTDWDSVIGDLRKDNGDLDELKKILDGTPCPIKEKRKDKESESGPKPMTGPEPEPEPEPEPGFESESESESESEYSEEAKSLKKSRVEAPPAKVPETPKEVVPEKKVAAPKKPEVPLEINSAGNQNQGKKAESAQNQGKKAEGNQNQGNDHSVANTSISPVSQAVRTQSSSVQSPDSGSPGATGPSSGPGPGGQADVSDAGQPGVQKAQANGDANGTASNTPGAGSVGDVGNGGSGGPGHQGENPQVPVDNCPSSKGFMKIKLWRDGGTYCVRQADYNEQEKRNKKWDEQQREYDKRMEQIRIEEQEAQQKQEVNQGRKDARAYRKEVVNDQRETLESMERKPQQIHDQYPSELRQMQQEQLLALEGSVITNTKPRAHMDVDKVYRHTLSDVDGRMISDTDRAVVAFYGDEFGRGEIPPVEAVPSTKSHVSDVIGMPTASIAVPAPPVSYHPSRENRLGMIPPVEAVPSTKSHVSDVIGMPTASIAVPAPPVSYHPSRENRLGMIPPVEAVPSTKSHVSDVIGMPTASIVVPAPPVSYHPSRENRLGMIPPVEAVPSTKSHVSDVIGMPTASIAVPAPPVSYHPSRENRLGMIPPVEAVPSTKSHVSDVIGMPTASIVVPAPPVSYHPSRENRLGMIPPVEAVQSTKSHVSDVIGMPTASIAVPAPPVSYHPSRENRLGMIPPPVEENPSTNDQRDSTLKPDDISVGGSVIPMMPFPGVYNIELSLPQKPKVQVIPNPKQRSPLPPIALSEYSGHHYYIPSKYPFIATVDDQTVEKMLNVTGTSNKLQTAQIVGDSNVATLSTPELTGNIISAFKQDPRTSRFPPTSKPYGDDDDASVEYASAVTFNDNIMKTMAGVAGHPVVGTNGQVDISQIPTAISLDAGDIHHLEGQEIEDSFTMKRQEQDLLNFQNEELKQGSQNAQRERELLALKQESDHINEEQKKLMQAAQVDADRIRAFKDSQFDISSAPLRVDEMQFDIQIDVPKRPLQDSSYDIDLDDPYANTADILKDELKPSDDEGFSGLPNTNFDLNFAPERIGLDGYEDPGMPSDSPRKASERVINPFSTDECLNPWSVDTSTSSTDTIQPPTSPPPASDHLPPPRTVREMLYWFVGLNTYGYIGIITQHIKSILKRFKNDAIEVTLEPYTLDASHVADKLTEACLYSATVIYKIKHTNVSDAFKDFFKDKEKYAYYYSPDPACLLCQLRDYVYACHHQLQFLKAQCKRDKLSGGWQDCKYGSDIKTPSPLQAFLTDDWDSKFKTHPFDPCNLCLKSRVRMGFKKDDLPKISQQGSVLSNILTPSCGGEGDGDDDVRGGECYSHLAAHLIDHQCNHHFVYNIRCQLPVGLLRSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8A6</accession>
    <name>A0A061D8A6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769107.1">
        <property type="nucleotide sequence ID" value="XM_012913653.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8A6"/>
    <dbReference type="GeneID" id="24565462"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308250"/>
    <dbReference type="OMA" id="LKGCWVK"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF3">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="101"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="553"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1303" mass="146194" checksum="F0FA7D83447B6094" modified="2014-09-03" version="1">MSRMESVRQEPEDSGRSSLQRSMDVFWAVSNLSMEWNKKLLMGSFVTSDKKDRYWKESHRAMAQLIVDSIKNLKGCWVKVGQILSTKPGMLPRCYVEALSQLQDRMGHSDFAEIIDTLEEEVGYMDDIFKNFDSIPLASASIAQVHKAMLHDGNVVAIKVQHRCSEQNLRNDLEILKMILWVAQSMGQYKRMFASIDDYTSAAMQEIDFMIEAESCRLARVDAELSGIPIVVPRVFEKYCSKRVITMEFFELYKMTDVKFFRDNNIDASGIVYDVQDFAIYQILSSGRFHGDPHPGNLLLTRSKVDGKFYPVLLDWGMTQSLTTKQRVGLCHLTYALCIGDTIGCFTGFVEAGFDMTARKDFSYERFLESLLKIFSSDFSKVMDYCAEDGSMNLTSEDDTPGEWHYMGRMFIKDFVINAPNFFPILLKVVSEYRNYAIMLNVRLPFLQILYKNSGNALYNVYYTPLLHLMLSESNKAKFIRKARRVKQVLSADCVEVTDEQIVTKVLMEVSSSNKSKVRLSEPISFRKPRGLLEAKVSAFLSHIAKDSSLLVAAQVCVMRNGVVEVDLAHGSMGKYECRPVKSVALFQVSHMMNGLIATAVLNLTTHYDVSLDDPISKHWPEFGQNDKEHITIREMLNHSSGLVMPYPNILLVDNLDYETMIKEIQQTNLHKEAIGMTNYGYLYFGWIMAELVRRVTGKSIEEYILDLARDVSVPLGQLVFPSLQINWDVHAPEAPVNDGSYEVVHLDPASAMDLDEQMIDIPLGSPGCHESSEDSTPAFCKSPAVALDAVSPLAGSMQAAPAIKSDINLNDSVGSASKLMVPDPHQAYGDGGSAAADKRTSAQDTTTTLFVDIESSDTRLQSSAELSKFTSEEVMGTIVADGKEIPMSKFTMIQTQSWANKSLDSSGSHDMLDLLPPDVTQGSSPDNELANPQGDVECVGLEATVDINEVLMSKDEFLALPQKSDALPTAEQNINNAKAIKRSKRRRCVGRMLLRLGAVAREAVETAAPQRRCWCTLTADSDELTYHRCFYPSSRCPVQTRFVRHHRTPFMRLEELDVAETEKMFNQNIAEGTNGRYDPVLVSDNDVVTDDEELSELDLMEEDQRLSRLRLRKFIMKRNPVQRVFHHSNYDVINYRCIITDPMSLEYESIYQKSVPGLNGRASAVALSRFYQAVLDGTLVDRRLLAEAERTVAVDRSVITKVMTAMYTPAWGLGYQRFHLRRQGSGEELIGLGAVDVSGSLTLMVPKLKLVVTMLFSSTRSVAVSHVLLSLVLGHYGLELAHANLNVGDPTSLYRLLATIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H9</accession>
    <name>A0A061D8H9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769202.1">
        <property type="nucleotide sequence ID" value="XM_012913748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H9"/>
    <dbReference type="GeneID" id="24565557"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309190"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="62" mass="6751" checksum="4FF5AA7577DF4811" modified="2014-09-03" version="1">MDFASASGVVFAVLAFILFTSLIGYAIYLYKTKSTAYLIPKEVYEWTGYTSACTGPGSKHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I8</accession>
    <name>A0A061D8I8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0307220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769004.1">
        <property type="nucleotide sequence ID" value="XM_012913550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I8"/>
    <dbReference type="STRING" id="5866.A0A061D8I8"/>
    <dbReference type="GeneID" id="24565359"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307220"/>
    <dbReference type="OMA" id="TLFRGCP"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="123"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="225"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="321" mass="35580" checksum="5C174A488A1741E7" modified="2014-09-03" version="1">MGQDGDAASVAAEPRGTLTVEQLKSHPTFTALANAVAGATCTLLLQPIASLRTRLQSLNIYDHGIQGGNRSKFAAMLRLSWRDGILRLYRGGGCSMVISGAGWFLFRYSFDMISHSKIVDFDNKNATKLVNGSLSSLITTAVLHPAWNAKLNMELQTSSTMVDGWPQYRGATHYLLSTFKNEGLPGLYKGWEANLIGVVYYGMVICVYESLAEVDWQQHRFLESVQYAKPIANGMIARIIPTTLCYPVYVSRTMQQCFATELSHRSLFQVFAWTLRNKRLRGLYAGFQMQLAKSVISGGITFGIYEALLASAARCYNFIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I9</accession>
    <name>A0A061D8I9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767415.1">
        <property type="nucleotide sequence ID" value="XM_012911961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I9"/>
    <dbReference type="GeneID" id="24563770"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203870"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="141" mass="15390" checksum="D186E439F9F78748" modified="2014-09-03" version="1">MASTVKQPVAVRVTPIENVSHLYKDATAPQFVANDTDFQIEFADLEGRTVLQEPSRKVVMCYVDRTTTAPPPAPPQPTPSVNVTLQQPQAPPQLVVQPAAITIASVQRTSRRCVTLLLSIFMILFVCAAIAFAARSKLMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8X3</accession>
    <name>A0A061D8X3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spindle assembly abnormal protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766376.1">
        <property type="nucleotide sequence ID" value="XM_012910922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8X3"/>
    <dbReference type="STRING" id="5866.A0A061D8X3"/>
    <dbReference type="GeneID" id="24562731"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104990"/>
    <dbReference type="OMA" id="DYPAICI"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230">
        <property type="entry name" value="ASSEMBLY ABNORMAL PROTEIN 6, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="176" mass="20442" checksum="A1D937EC68848067" modified="2014-09-03" version="1">MCTLFLGECKAEVRGTVSDLGGTKGHFNFKVTRGNDVVELEITSESDLFFNYIHRVTRDDYDVICKRQRLTAEFADYADTLSRMILSCIESESFLAFIFLNGGEGTLQFVQNADYKFIELLECNLQRANEFRIVENITYRYNTLKERLNHFGKHLEDVSTYLKTKDPECTRQRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C8</accession>
    <name>A0A061D9C8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769339.1">
        <property type="nucleotide sequence ID" value="XM_012913885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9C8"/>
    <dbReference type="STRING" id="5866.A0A061D9C8"/>
    <dbReference type="GeneID" id="24565694"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310560"/>
    <dbReference type="OMA" id="NCFFRET"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="227" mass="24969" checksum="44FEB58C7FE19390" modified="2014-09-03" version="1">MAAESGSAIGSGGGSVSSQRIKIVLLGEQNTGKTSIVTRFVYDHFVPAYAATIGIDFLSKVVTVNGKTMRLQLWDTAGQERFRTLMPSYIRDSSAAIVVYDITSRESFDKVGDWIKDIKELRGDKAVIVLVGNKTDLLDKRKVSYDEGEEQAKKFGCLFCETSAKNGDNINDLFNPIATELLKNMEPVPVNDKLVDIDLKASNEEAPNNCADRTKNTYLTITKRCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9E9</accession>
    <name>A0A061D9E9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767740.1">
        <property type="nucleotide sequence ID" value="XM_012912286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9E9"/>
    <dbReference type="GeneID" id="24564095"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207120"/>
    <dbReference type="OMA" id="GRIFNVR"/>
    <dbReference type="OrthoDB" id="365009at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="739" mass="83808" checksum="30038D17B0E95CA9" modified="2014-09-03" version="1">MVFARRLSAKKARFTCKKLAFLEVQRFQREEYGRWLTRRKRAERVLFLPSVKDEVGELSAESMQRILHQGSAFHFSKHLVVERQDSLHHLLFGGVLNVRRLDPIDLVLLVSVLTKLPSTNNALLSRALLQCDLHFESLSLPEVAQVSFLIRELPESLRESFIRQWLPKVVRLLSRLNLDGVGANLSSLAKLCFTISHFAPHLRHPLFVMLTSLEVGDIPDPQLFSRDCSLVCESMSSSGVVNYGFLKDACHFYESQLNKTVESLSDRLRRRQALSGHNVVFHLEDGGIESAVDIEHLLTFVSTCERFGYHKKTLMEALDRYVDCCSVVFVNECRAAEHYRRHGTSTSDQLPRKFAEAVRSGRYRHPVSGKQQLQKLLRDLLASLSTEKHGYWCLGAIHSIGTKYVTQRRTFARFLDFVMRNINKDMLTTAEQRILRGLCSSYQPFLCELTAHLGALMRDSAIQAAEQPQTQPHHNCTGEMRSVDFCNIASTVNSFRETCASYIADRRPESLTTLLSLFPILAAKLPDIVCWDCVWQMLNVIAESRCIDMLPLVRSFLEESFLAFQPLSQAAGDISTVTAHLIGSECTTDGYLLYLDSCVRIVELLSEADLSRDDADLSMFGHFFELLTKVGHVLQRHSDGFDADRRLAIERLHSLLQRYLVKFSEVKRYLPGVEVPNAVYVQVMGGIYRQCGLDSTPAAMSAEKAVELLRCLRVAENTAFISKNTDLVRHILFQGCLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9F4</accession>
    <name>A0A061D9F4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaK family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0310810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769364.1">
        <property type="nucleotide sequence ID" value="XM_012913910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9F4"/>
    <dbReference type="STRING" id="5866.A0A061D9F4"/>
    <dbReference type="GeneID" id="24565719"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310810"/>
    <dbReference type="OMA" id="APVHIEC"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11732">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSP105-110-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="705"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="741" mass="82398" checksum="5F55ED716669FD04" modified="2014-09-03" version="1">MPVLGIDIGDGSATVATIAKGAIDIVLNEVSQRYTPVCASYTQKRRLFGDQATPQMISNCRNSCRNMMSLLGKTMGGDPELEVSAMDDFFSPNGISICSNGYAGYNVAISSEPYEVTKVLAGYISFLSEMADNYTKGPCREVVLACPGWYSEVQKEALKVAAMAAGLSCLNVLDECTAMALDYGVYRVKQLSDEKPTTVAIVMIGHSHASAAVCDFYQNHVEILSKVSRQNLGGRNLDHMLMKHMADGFERKYGCNPLDNRKIRLKLEAVAIKTKRVLSANSESGYSAECLMEDNDLQGNIKRDDFEEMCKQEFLPNITEMLMECVNLCGKAVEDISCVEIAGGVTRIPCVQKTISDIFGKQLSRTLNSDECVARGCVLDAAMRSISYRVRKYHVVERITRPLSLACIPGGDISQMASAETVEILPANSSKSTPIAAKLAVTAPAILIASLGDPKDPSDAYFLGAIQIVKQVQPTEEQGVTTVSAVFDENGVFFFTAVEGHEFVTMPRSSAFTVEAYAQAEAEAKAQDSIENQRLRTLNDFETLIYSVKEKMQGSHREYVAPEFVGTINEELNKWSNWLYDNYEASLEVLQDSLKRMQSDWEPIERLYGIQKAKENELDVFLSGLQSRHSMCCEDGPMWYGAPEEERLEFAQKIQAFEAKVRQQAEEEKAMPRHAEPLFTMEQLQTELRQINSEIDEFCRRMRVQSERRKEEEMAASQKAEEAEPAQNEPAEEQPADQDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9M9</accession>
    <name>A0A061D9M9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0311410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769424.1">
        <property type="nucleotide sequence ID" value="XM_012913970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9M9"/>
    <dbReference type="STRING" id="5866.A0A061D9M9"/>
    <dbReference type="GeneID" id="24565779"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311410"/>
    <dbReference type="OMA" id="AGWFIRN"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="527" mass="60608" checksum="41B661F18D363091" modified="2014-09-03" version="1">MSSGEFVRRIQGGESPQRGLGGVIPRESEVVQFLLNLYDGLYNRNAEEVKALYEQDLAIITDNHFKTARWPSISEVAGFYSQSGRLHSLIMALYSEIYYRHVFYLGDVTYEDRLDSWEKYCKLLGYFVDELEKGDESDSLSGLVIPASWAWDIVDEFVYQLQECCRWRSRLSRTEDANVDDGVKVNAIWKVPTVLEMLHRLAVNPAYKNSTHDLQTDGLETAGLGYQLGYFASISLVRLHVLLGDYYTSVRMAASIDYSSKFLYWKVPSYYVSLSYHLGFAYMMLRRYGDCIKILSQILIFLTKQRSYLVTQSYQQGAMAKLTEKMYIILVLCHTTTKIRLDETLTQTIKEQYANRFYQLQSDNEEAYRDAFLKCCPKFIDASSDNVTSKVDDSDITGGVLIEPVLRQLNLFLKEISNQRRVDEIYSFAKLYHNISLEKLAALMKMGDDPELVRSCVLSVKHQTRQFANAAGGSDSMPAGNEGDIDLYIDQNVLYIKSKQSQKLYVDYFLQQINRCKHTLRNLQSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9N6</accession>
    <name>A0A061D9N6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0207880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767820.1">
        <property type="nucleotide sequence ID" value="XM_012912366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9N6"/>
    <dbReference type="GeneID" id="24564175"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207880"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="811"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="941" mass="106895" checksum="8399669A7D506672" modified="2014-09-03" version="1">MYALRCDFGVPADLLSNNALVRCHMNIDLIGSATIICPRRVQDTEYVWHPQPMSDGQSHINTYVYGNGKFRSVIFTDVVRSEYNTALIGFDSDASQTKLTVNFPIYDIYSITDHRLIFICGPKDLVLSDALQRRLHRLDGYGQMQSLPWGSSTLLNKEIREIGKGLGVFYINRGLLHLPLHGCGSSPSPLFNDSEVTVDPVTGIRSCVADPMSTFRIGFLCEGRIEPVDCMRRLLVNDDVVDAPLPYYYWNYDNYQPWVVARYFNDLVLPPFHGECRCKDPNTGKVTARMEIRPKTEYLCDITTNIFRDRVRPIRGAWCSVALHPGSTLTIKVPTQPVNPISMRDDHNIDIDEDVSSVPFSQLPFIYEYVTEFMPNDLTTLRQLKTLDDLDVYTETSYHRVLAGDALDLDVSQMNKGLVKLTYRSDKPLALIQGHNSFFYHWTLGSKNMYVLDRIFAIVNVSFAFTHIYKIIGCDRSTPGVFDQYASRNYCSTRRMRNGIGDTYECSLHIVRDDKQAGIYCGPDEELLPDNCDSVLYDLHYNKVMPYAASVRKAVSQSIRGFQVFEFAFINNAPLSYACICVDEHGYEKSRLVLESNRHDRHVYTVRREAPVHTLLPYILLPWRDAGFSTEWLTSPKSLILHNIHPKSVVVHAGTTLSMTCVFDPYVPNGANIGYITTTWLPMQPDVFYYTVNETTHGRQLIRKRYEDAVATTPGDLEVKFQEIDRRPWYHILMMISNKRGIIVSKDPKNTKYIPMAFVCGKAPEPFDLSISTGDVSPSDLSRQEFYRTTVSFARYTWHVVEVAVKTTDPYMQGCGVTSSSDELFKPETPQIYDADAQSQFGCKIDLQTAGEAAFYCPVPYVLDPPNCFEQVSVDGEVKNLSDISRSLVASHSNHFVTLRFDRELVGAGDMLRQTPPLECRCVTIKGIVLSTIQIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9T3</accession>
    <name>A0A061D9T3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bromodomain/ankyrin repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0107930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766681.1">
        <property type="nucleotide sequence ID" value="XM_012911227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9T3"/>
    <dbReference type="STRING" id="5866.A0A061D9T3"/>
    <dbReference type="GeneID" id="24563036"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107930"/>
    <dbReference type="OMA" id="CNPNDAD"/>
    <dbReference type="OrthoDB" id="448960at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="6">
        <location>
            <begin position="341"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="464" mass="52938" checksum="F745D0A22EDB696F" modified="2014-09-03" version="1">MATVYAESYIKSPLVQAIGADGVQTMREVLERDFSDCSAEHLESNPELLVSEEYMNKKNSLVEPNTRITPLCQLSRKTEDEALEIAKMLITEYKLVDANHVDLMGQTALFYAARDGWSKFCEFLAQNGCDPNHQDRLGQTCLFYASREGHHETLEALIACKADVNLVDTNKQNCLFYAARDGRMEAVKVLIKHGINYNLKDAQRRQAITFAKLKNQTEIVNLLKSMSKSESQHVKRPLTDPADVQGLLQSASTADEIKSGVPVVVKEAGKPRKYRLQFRPFEDDANLWVDAPLVKIREFELRFPELATWDKTAPFAPLSTLRNPLVKQWHQIGLNLLSMMGKQEGGYVFERPVDPKKQNCPDYFDIVKKPISYSCIRSKIKKNVYTSPKEFVEDCQLVFDNCFKYNKPDTWVAQVGRNIETFFKEQLKELDFEAFINKHDKLNELLETANQYVESNEVPAEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U4</accession>
    <name>A0A061D9U4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768928.1">
        <property type="nucleotide sequence ID" value="XM_012913474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9U4"/>
    <dbReference type="GeneID" id="24565283"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306460"/>
    <dbReference type="OMA" id="ITSHRDK"/>
    <dbReference type="OrthoDB" id="365196at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="136" mass="16006" checksum="A62BAD9EBA262E98" modified="2014-09-03" version="1">MSDLMHIVDKLREAAMQAKRECDTQVEQVLTRMTKKIKDDITSHRDKLLQQRKTLVEQEEKEHVTQKQQVSGPCQKAHHAQLDANIKEFERLKRSLIELLETHKVKQKKMNHCKCLMLRDDETLVKVHHMLTGNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U8</accession>
    <name>A0A061D9U8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0306510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768933.1">
        <property type="nucleotide sequence ID" value="XM_012913479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9U8"/>
    <dbReference type="STRING" id="5866.A0A061D9U8"/>
    <dbReference type="GeneID" id="24565288"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306510"/>
    <dbReference type="OMA" id="SAWKNDP"/>
    <dbReference type="OrthoDB" id="364387at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="196" mass="21650" checksum="13C677A5ACCF63BF" modified="2014-09-03" version="1">MKNADSFASDTEDSPADIANIHRNVLNPELEKEVEDAFALFDRDGNGQIDFFECQAAFRALRLNASRDAVTTMFAEINKGQHDAITLADFKTLVLKVIHKRYTAGEAAKIFALLEDGSGKITMDSLRAVVADLGRGYPLWNLTVAVGSSIDDEDLGLMISEASGSKDYVTYEDFRKVLKAAWRGDAMDRMEDATQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA06</accession>
    <name>A0A061DA06_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Homolog of Putative histone-lysine N-methyltransferase PFF1440w</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0312510</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769534.1">
        <property type="nucleotide sequence ID" value="XM_012914080.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DA06"/>
    <dbReference type="GeneID" id="24565889"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312510"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10518">
        <property type="entry name" value="SET_SETD1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838">
        <property type="entry name" value="HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="1782"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="1875"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="2162"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="4842"/>
            <end position="4962"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="4970"/>
            <end position="4986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="600"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1126"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1173"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1482"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2291"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2642"/>
            <end position="2690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3297"/>
            <end position="3340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="4438"/>
            <end position="4458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="4499"/>
            <end position="4526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="4540"/>
            <end position="4564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1200"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1510"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1528"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2291"/>
            <end position="2305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2663"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="3314"/>
            <end position="3327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="4438"/>
            <end position="4447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="4514"/>
            <end position="4525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR97348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="4986" mass="549873" checksum="240A5DE7B92F33E0" modified="2014-09-03" version="1">[encoded data, 4986 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA69</accession>
    <name>A0A061DA69_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769797.1">
        <property type="nucleotide sequence ID" value="XM_012914343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA69"/>
    <dbReference type="GeneID" id="24566152"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401030"/>
    <dbReference type="OrthoDB" id="366174at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="331" mass="36744" checksum="29EDAE180911E90E" modified="2014-09-03" version="1">MAEKEVVISRLQSALLRLPKDDLIKLLRSTYQAMRIKHGIPYERPESNTHSSAAQRETAARGVKATAARSKRKHSVGKRKPSDTPSDKGHFAKVEQPTFRQIDILADDFKDLNLSYDSDAFDLAEPSADNQQHASSPTHGGTVDRASVQESTLDDREFAIQTLKDDARQIVPPLDLSGISASAKEAYKVTDFLPSPEVCATGSFSESKNNVLLDPYVKLKHVTCPEAHPVGEFATDNFSGHWLRDSPGYSMPDNSKMPHPRTVVRGNYTVTPRPGQWVRGYPLPQHVYDPPYLHLPQAFGTMPGGQVAYRDMQRLGPCAPSQVRGRSVQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAE8</accession>
    <name>A0A061DAE8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769138.1">
        <property type="nucleotide sequence ID" value="XM_012913684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAE8"/>
    <dbReference type="STRING" id="5866.A0A061DAE8"/>
    <dbReference type="GeneID" id="24565493"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308550"/>
    <dbReference type="OMA" id="HEYMENL"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15036" checksum="665445B11D2276EF" modified="2014-09-03" version="1">MRDTSALSSVNIDLNNFPYCPLDGSGVRTAYGDTLSVHPMHDIDCKNLMKEEMAKSERLQKTLGYQAALKNSIELNTCSKSTRLPGMKSSMLSVEILMDKLDSLESYEYMNVEKPRHEFGIGGLHSLLETKFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAT8</accession>
    <name>A0A061DAT8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional regulatory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0111080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766996.1">
        <property type="nucleotide sequence ID" value="XM_012911542.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAT8"/>
    <dbReference type="GeneID" id="24563351"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111080"/>
    <dbReference type="OMA" id="IESITHT"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="16"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="251"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="692"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="11">
        <location>
            <begin position="1400"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="1809"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="873"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="880"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1153"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1173"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1205"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1307"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1329"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2152" mass="241192" checksum="D58473356073457B" modified="2014-09-03" version="1">MVAATHTPAARTNILQQLEQAENMTDEERVNKYFYNLYVSNITTDEMIEVMHRLDSSPDGSRNRDTYRTMLTILFNECRFFPKYPVQELAITAELFGKMIKEGLLTCNGNLLLLALRCIIESLRRGKSSKMFQFGTVALSQFETSIANFPWFASQLLDVPDVRETFPQLYKTCEKLQTIMTEAMLTTTYVDQYRGIILRPEDCFPGPILDAPDSEAPNIEMLLATADRDRLDVGEMESLMNGVAEEFTITVPPGPVVNLIYAAFNNMAADSAAQKAREVNEVLSPENVSWLLVYIIKTRASKEQNLHEVFVIFIENVKIPKIFDMAIQITYACISACLKNIVEFKGLASYRTLLRNLGSWIGRITVGRNMPIMSRHLDLKQVIYHAYENGAMIAALPFVCKIIENIKHSKIFKPPNPWTTAMLNFLVEVHRLKALKTSLVFEVEVLFKHLDLNMNSFANKTRLLESKVRPEDSPDFDISVIGHRVDKGAHQHAREPAPRKVKAPPLTSGTQTSTLTKAAQHAMQNALLTTMPPRQPVRSGGVYGSAPLLYTRGLPNYFYDLEIMRYMPLALQGAFVNDESVRDKLNILLGRVMRDKGNPKGEQGSLDSISEELLLALSSSFLGIPPESFKPGMSLPANMPSEQQSQLSTPPPPPVVENLANMPLSSYGERLLQKLHGAVIISPAIAIFEIQPQLRGCVPVAIERAIRRVLPIVSEHSISIARATTRVLITNDYAGEDDEVTLRGAIHTMMETFATSLVRATCKEPLRIAFHESLRAALQTYRTQDCNDQVLIEQLVQIISQDNLLPAVGVAEKIVGERAIREADALVPDIAKTCKTVPKITITLPPLLQQWNKLNVFVDKRNLTLYRSLFQRPNRPVAPPQHSQSQPAPQPKSQHNKQQQGQQQKHQQQQQSGQGQQQSHGQAGSQKHQQQQQQQSGQQGQQQSHGQSGNPKHQQQQQSGQGQQQSHGQSGNPKHQQQSGQQGQQQAHRNQQQQQSGPQAQQQVHRGQQQQQQLSGQAQQPKSQSLLGPNQQQKTQQLLGQAQPQKSQPLLTQGQQQKAQSLLTQIQQQKSQQLLGQAQQQKSQQLLGQAQQQKSQSLLGQVQQQAHRNQQQQQQQLLGQAQQPKSQSLLGPNQPQKNQPLLGQNQQQKSQPLLTQGQPQKNQQLLGQVQQPAHGQSGQPQKNQPLLAQNQQQKSQPLLAQNQPQKSQPLLAQNQQQKSQQLLGQAQQPAHGQSGQPQKSQSLLGQGQQQLHRVPQQQQQKHQQQQPQPQPPQHQNQQMPPQQHIPPVNHHQRPPMQQPQPQPPQRPAQQQAPQNPPQALAPASMPPSARGPPAVPMPMPMAPSNGILSRFEEAFGEVREPLRDIALFPPILYSQSPAERGKKPIMFSTHALLVLYSLPVDHEIFTCIANCLNVMQNSKDMEMASLAIAHRLIMFLCEGIGSHAGLNVEVLLCVLEGLARLNVAVKQAICSIIYANPVDESNTVFTVATITGLLRYNLLDWQQLTHFLILSMDKGKNVYAVEMTIVITAIAVVDQRSIHPERATQIIREIANTKCGQDMCENYPGIMLKDARSKLLKDYMDLHRDARIVVSSLTPIIKDNLSACVPYASFNIMCPESDTDPVPEVFLRETMIVNLGFGGVRRVSPPPAVSDSHRAIITIIFAKWIECSLSYEGDNLLLAWRQFFQRFNLQNLFKMDGGTDNFFAICVGSAVANSPSHGTPYTSAQLADSAFPYHPVDNMVALAKMVDVMQRLVGGSDVPPSSALQKLLSATASLIVYGERYMGYYKLWVVMMNYFDKIETLNGQIVCRITFLNALKIISPLRAPEFAYYWIRLVGHKSLLPGAMAVPRCWQLVAKLLLQATCFMQSTNAMEHTPHLEQVYYELVQRLCIDYPHFIVEYYFCIGGSPRIERLVGCCSIEPQSTPFGTLKTPVDHLPAMLYMPRVAPFIVTILFRHEIKPQLDILLRVMSHKNRLPPVSSINIYGADFEELLEVLEDVVINDPAQAPTLFTALTFYIGVEFPHAMAGQVQTDDTRIYLYMDLMRSLSMAGKYVFVNALCRHMRFPNAHTHFFSCLVLWMFDELREPGDEESRDVMLRVLLEHVLAPPECPWGVKLAVLELFSNPRFELSGSAFQLLPDPLQSIIDSVARVCSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV3</accession>
    <name>A0A061DAV3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767021.1">
        <property type="nucleotide sequence ID" value="XM_012911567.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAV3"/>
    <dbReference type="GeneID" id="24563376"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111330"/>
    <dbReference type="OrthoDB" id="367147at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1397" mass="154856" checksum="B9CC7FAA570A024E" modified="2014-09-03" version="1">MAAHGVKLDTLKDCLQFLEWLHSDKDMQYGVTRRLERLLEKRYEKVKEQPIAKALSQFLAHTSNFYKKLCHKAGQGEYKPGKPRDALYALLLCIPRLLAVMYFLRYQVDDKFDKVGGGKWAGNAPGWGVLGRSFEIIGGELDKYLHAQSTENKYGVIPGGFTKGDIQRNKSYAQGSLMAGDLEKICEKQNGQLFRDVFVISVLSKTSGADTANVANALRLVEDFYGIFRGVTGEKDFTSDLQSRDNCISWRALKDHCIKSKDPLEKIFKKHQFSFTGYAQRYEYLNKEKIASKMAKWLQKNLGDVRSKLKGITPQVDAKTFATTSLFPYGFTFYDSDFKKKKNPYQAFKKDWDTVIGDLQKDNGDLAKLKDILDGNRCANGQKKKEPKPKPKAKPTPDAGSEPAPEPEPEPGPKHEDEPEDDDYLESDVDSDEDLMNALSDEESEATKTEAAKPVVTKTEATKTDDAEPTANQGKKAEGAQNQDKNAEHSSTALQQDAHTQSPGAPGSSSGQGTGDQRSASDADQGSGLKSQSGAGASSSLPAAPGTSPGGGGGGGGGESGEKGDGKAKQGAVDCPPKFTPVELWQGSGKYCIRDVDYKEQGKRHKQWDEDLEKTQRNVQERIRKAEDKLRRQKEAEERIKEDEKQRMEEEEREKEKHRQLQREAMLPEIDVYKQQDGRLFDIGENDKSNFHQFFRNDLNVRGEVIRESPDVTLEIMHPTVPAETEEEELPNYPMPQSSQPLSPPTVDGSAVTSNSDNFIRPDSPAKAFSAISITPTGFDGQPVVKQIPKRNHSGANKRLRQYLTKYADVETSVIEPIKLTHKPKHIMVEGHTTPNSKGVQRSMPPEFFASIGIPQGQPLKPSDTRVYMPPKTDMMGQATADSKGIQNFAVPQGSAAIGIPMGYTIKDPKTPTRSTIHLLPAPKLSTKPIRMKPTGIAMPAHKHPPILRHAPITTETSDDPSMARFLNVSGTSLTKSSKANAKAPVLQEIDPPVPQSMLSGSHVPDAELPSSPLPRDTFLTEPQPTMGFQIEFPKRTVRNVEPEIGLSIEVAHHGDRTINDIDLYDPYANTADIIKDELRPAEDKGFSGLPQTNFDLNFAPERIGLEGYDDPGMPRDSPRKADERVITPFGRDECLNPWSVDPSSTDTAPVTHSPSPATDHLPPPQTVREMLCWFVGLSQYGLIGVVTEHVYSLLRELNKDTSHPTDAIEVTGDPGQLTASMVIAKLTEACLYSATVIYKVRHNNDFKAFSTFDFKKEYSQLHYAADPACLLCQLRDYVYACHHQLEFLKAQCSRAKLSGGWRDCHYGSDITASEYPLQAFLTDGWDSDFETHLFDPCNLCLKSRVRMGFRMEDLPEKSQLGSVISSILTPSCGGEDPLLRLSSYLNCLTKIQGHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAW9</accession>
    <name>A0A061DAW9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0212110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768255.1">
        <property type="nucleotide sequence ID" value="XM_012912801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAW9"/>
    <dbReference type="STRING" id="5866.A0A061DAW9"/>
    <dbReference type="GeneID" id="24564610"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212110"/>
    <dbReference type="OMA" id="VLIHNNC"/>
    <dbReference type="OrthoDB" id="361321at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="460"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="569" mass="63646" checksum="099D6FCB2831F290" modified="2014-09-03" version="1">MKQLQSVGRPVSSSALMSLLEVYDSSEWHEIASQDLPALPSKAKSAGTVDNAKLLRSGKELMAVLARAYSRHVCDTDTEKAWMRAVAKDPFIPPDKKNTATLCDSLDAMAVLASESCALNYKFITLLLGMCQNTATRVMLCSMERMHALFMEVLPGRKLRYIDQLDASRQRYLQHHLLTWEKGGAATWDSLEPLARVVLHVLCFEDFLKGAYAAFIQLVTDQLDGGPPFVQRKMLHYVLEMLAKKPEQEGLLLDILVGRLFSNDLKLSAMASAKLTSLLECHGGMKDIVVRRVGSMLLGSIGKVHTTFASHNDAAATKKKKKRRSKALPSELIPILRSIHRGVLFLTEIHFTRKDTKATSEALKCYMCVLSFIFKPSTGDKRSRLLPTYEYDEFSRIIRCISSGLERCISLVRHREGSFDIFDYGSGEGDASRESMEKSIASLFRAARKPISCSTNIGLLSLIAQIQRSEDRFYNLLYERILDIRMYAAVNRRALLTLAANCMSNDKDTCRVAAFVKRLLQVCCILGCRSHSSGCVVYCGRRGVHGHLPNMPRRNMRKYTASCDDKGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB23</accession>
    <name>A0A061DB23_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767111.1">
        <property type="nucleotide sequence ID" value="XM_012911657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB23"/>
    <dbReference type="GeneID" id="24563466"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200820"/>
    <dbReference type="OMA" id="GKFPLIW"/>
    <dbReference type="OrthoDB" id="390891at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="359" mass="40939" checksum="EFF367C9DC097E8D" modified="2014-09-03" version="1">MDDNEAAITNNCSYSLRKRKRPVIVEPVEYDDDDGSDLDSFRVEDEAKAWDMFYSDRRQSDEPFSGVNAKEAVSMIYSAIRRIRSPPLVDSRDFIMEVGHGKHPLIWDLQRAFKNFGSYTGVEFSGDSILEAINLRARTHESEEASDLADNVEFLRATSINYFNSDGSCNAEVIIPADRYTPRLTAGSVTLVLAKSTLDYITCRLTGSVSTLNWDENPRISPAVVEMFDSFSTALGKVSESRPKAIIFVEPGDFIKFRDHIATIARVIYDATFRRNSPAKWLRLTHVRRNKTYKAAIYTLEKTNQAYESYQEMRDDIRQLTARIYELSGAQDDDWLLPTTVPPRWNTHNHGDFEQLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB44</accession>
    <name>A0A061DB44_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0311050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769388.1">
        <property type="nucleotide sequence ID" value="XM_012913934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB44"/>
    <dbReference type="STRING" id="5866.A0A061DB44"/>
    <dbReference type="GeneID" id="24565743"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311050"/>
    <dbReference type="OMA" id="AMASFHK"/>
    <dbReference type="OrthoDB" id="364386at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="8">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="537"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1102" mass="122795" checksum="2C8FC092AFE17539" modified="2014-09-03" version="1">MSRQTSLINRPETADMMELAQGVKKVEWITDSRSPLCGTFIVYLEDHTFGTLMRSRLSKDERVAFVGYRVPHPLENKLEIRLRCKVDSPFTVMLNALSSVRSNVAHLKKVYMVGYCRSCRKDGVDIEDWKVCISPQVEPYITTTHITALDVCKAPVTLSNYNFVVVLGYANGIICLSGVDAQGQFHIVSHNDRNSAQVLHLEVHVDIEADKRGKAALHSFALFEGGTIVRFAWDTLQQISIECGYGINGMHASLAHSVIAQYAPDRMVLRCLDTDSILRTFENIGSDTWEEWALAFHPHRRLLAFAGTNAIRYTSAPRWEIYQFGDGVVHSEPISCLQFTALGDIVVLLTASQDNIAVWDFDTQSVLYRRTGCEFRLCFLTDLRENEVSLAILGHVYDRKPWTLTRLTLPADDRMEEVGVKRLAEASSSSKGADAQVNKRLRRMVDDEAEDAGDDVAEDAGDDVAEDEGGLFDGVDNIDVDAEKPEAPASPSRHRRRNVDVFDVLNDESSIALMEDIERLKRRVAQLERRTEARYNLTPGSCPAPHDESSQWLMYWDDGGQITKQGSGDSTTLHVHLYSGPNAGYIQKHDSHNCHTAALCGRALVTGSELAVDNAPQGLLTVYNLGTNEIWQRRLRHESIASVAVSDEFVAVLGDGVLYIFSFAGSMLGVYRLKGAPVGLAAKGNILAVISECTSNPRSSTVYSTRLLWVNGLRGLARNSLNRVVDLYDDVLVLPPNRHVSWLSISDQLNLWVGDSSGQLMSLVPAMASFHKLGGVSFEWVPSLHLADLGGESSSEEKSNRIRAFPLYVNEQKLCYIRLKEGERYPHSHAPVNFLGYTLRKAPLRIEGASGAYMPFNKFHSVMTRDPKLKEVGPAGIVEDVAAIPWQQYDEMRHSLTLQGAQLELLMQLQQAYGFWFRDAERVTQKAATSMGNVELVHDKWLLRMLRKVKGQRQDSNVLYDVLRMIRYQRCLDTAAEILSDQMDGRQRRVLREASMLLANGPNRDFLFPSRENKAPDANDAQQPRADGEPDAGRGVHDVTVLNRTVVADKDTVPVSVAAPAKAVPPSAAPKPKAPAKPVHGFVEVDGNPEDKSNWMEQVFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB61</accession>
    <name>A0A061DB61_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0311200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769403.1">
        <property type="nucleotide sequence ID" value="XM_012913949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB61"/>
    <dbReference type="GeneID" id="24565758"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311200"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="563" mass="62178" checksum="DAE4E642A8B4CFA9" modified="2014-09-03" version="1">MSGPQAPSPASATGELQQAETAKKIKAEYGTFGQVLYHLVSFTEGYEQQVLYLCMRLFESTMGFTKQQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSSTSRFSSILFLRFLHGAAFGCIYPVQQKIISDEDDDQEGGSSSAFTRIHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYVWISVGIAIVFAMHTDKVVTTPYQSTTDFINRISGAFKAVFRSWSSFLCIFTMLISEAPMCTLPYMITYLEYLGVSDMKVGIAIVVTTIGGAAGTAAGGIVIENITKTHKEYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIEDKYQASASAIIQCISGISISVSFVEIFAYVSEKLHGYAPSTQAIDDMDAALKDNNTEALRKSTMYMIVIGSLLNIACYGALFATYKKDKETIVPDNKKEWEDRNKRQEIRDEMKKKKPEEVAILEVPADPETRSRVEVEVKAQGDDEVNMLTELPRPEGRSDDDDEVLSSDEAVRNYLSTTGRSWERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB85</accession>
    <name>A0A061DB85_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767186.1">
        <property type="nucleotide sequence ID" value="XM_012911732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB85"/>
    <dbReference type="GeneID" id="24563541"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201570"/>
    <dbReference type="OMA" id="NPFTVHA"/>
    <dbReference type="OrthoDB" id="345964at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="294" mass="33057" checksum="549CDB4C278971E3" modified="2014-09-03" version="1">MDNLEVFARRIAESVKPEWQLIPDPNSAEWQKSFDSVVDAYLKGEGASCDYYKDITTPVAALPHANLDGTTPEERFALACRIHAIMEGLWLAGRRNIDAIEQCARSSPLKLDDVVSYALRLRGTTYSPPENMNVHDPTQHYDMFPRYHFLGMPDVAQMHASRLFALSRLAQQSSAPRVIFEAVGEDMHRMRLECATPGAEVHYQTQRVNTQQINPQTGQPAVYTTAPAIYDSTKKFNFKTICNPFVVFAWSTCEGLRPSEMVKAEYVPPSVAKQETGAASKKTFGFFLGRERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB94</accession>
    <name>A0A061DB94_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769433.1">
        <property type="nucleotide sequence ID" value="XM_012913979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB94"/>
    <dbReference type="GeneID" id="24565788"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311500"/>
    <dbReference type="OMA" id="GAANNIC"/>
    <dbReference type="OrthoDB" id="365846at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="355" mass="39203" checksum="D6CD58A1C45A6E38" modified="2014-09-03" version="1">MPPAPPGIRQRAVYSELLVSTGLLFERRHKARQLADLAQLHLQAKCYLDRWVNSEQEAREVEVTLEDEGEQSPGISDVPGDDLNVGGPVIRSVASDAAYTSEDNWNVYHRTGTKVYLTKTNNLNYEATGYSLQSDFADTDCIDTPTQLAASSSVDSIVQVYSVATAASGDTVVSICGEENTVVGASAETHAAENKERYPNRTVAKIIWTCCFLTQIIVSAVIVASLHLSNRWNWHEKFRSFHIVYPFVTYFSTRVIAQTAIDWALTRYVRSYNTPAKTDTRLELYHLINGAINNTCLVLAVAAASLPNIASEELIVYATETSAYFGIIAAILAINLIATVYQCCSKYRLLRDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBA6</accession>
    <name>A0A061DBA6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770167.1">
        <property type="nucleotide sequence ID" value="XM_012914713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBA6"/>
    <dbReference type="GeneID" id="24566522"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404680"/>
    <dbReference type="OrthoDB" id="366407at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600227" evidence="1">
        <location>
            <begin position="22"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="473" mass="52278" checksum="ADE6C79B990EADB8" modified="2014-09-03" version="1">MNLLSKHCIAASVLAGCLVSGIVIDLASDVLPDCVEVFYGTFPNGGIYRFIRGTDEMITGLHYDGHYSHHFSLKITGLVYSYVEDFRRDEEHYVRHHVARQSGGRVVRRSKTGLRVGLELIPQWMPQLATFISGWVLLPVDARLGFPQHPLVCVTRDYLKSGSVRCRLTQQFLTNTGLIVKTFPKIFKLGEIHASHINGIALGCKCRLLMASNFIVSYREDPYFYIVTDTTDVQVDVTDMLERNVSDACITSPTSSGPLGYKGSEGGAPSFDLTSPEVSDANGLIEVNEATPGAAHMATRSIYVLVPTQLGYEPRFEEYATYDPSSNTVTYDIDFLTTHYAPQCEGEARTYIRMRAVRAVVRSDSTCVFFCAASTDAPIDSRDDAQPTESVSTSTDDANDLVDMDNFIEQMMLPGMDTISDLLNASGIPIDDAEDFELSDLQPTIGDERPALYQSAESSYDTLWAIYDGAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF1</accession>
    <name>A0A061DBF1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768415.1">
        <property type="nucleotide sequence ID" value="XM_012912961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF1"/>
    <dbReference type="GeneID" id="24564770"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301330"/>
    <dbReference type="OMA" id="MEHEENC"/>
    <dbReference type="OrthoDB" id="343184at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="511" mass="58280" checksum="3FBEAE733B856A1E" modified="2014-09-03" version="1">MEHEENCPWNQSRPLINTSIQRPCESRKCAVWKDLKSWFGYVGSGLSKLAFEEVFRDVAHGGSGLYERMAVEGGDMLREASRAFAAKKAEDNQILISAVRFIFHGVRQKKALELFKKLFVQKEVTIMNETSLLNYFAKSYLSAAQFLNSPRSVSNYVRVLLSYSLNEIAGQDFHRKPTEWLPTLLQHIYHSQTFRHLQCNSDNLLLRDLHLIFDYKYDYFLPRIQECFDNPDAAHHVSFVVAGCKHDVQCTQTSGVELLSNFASKYFCELYKAHYGHDNAALSAEYANNQSREFIRSNAIEVFACVYMRLHLVYIGEEVDYMRLRSSQDCRTIFLNLVGACWSISQKETRTAWMANLFHSLRQVQLAITMNGLVHTASTTDENILASGDAVLENAASHPLDFSAMFCNTKPVQEGVRPTGCFLDRVVEKTMDLFSRPDKTCVEPDVRQDNTLPIRVQYDQDSGDASVHIPLGKLGDMEPVNYRTVLKRKGERVMEIAVSNKGTLPLLDIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF4</accession>
    <name>A0A061DBF4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767261.1">
        <property type="nucleotide sequence ID" value="XM_012911807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF4"/>
    <dbReference type="GeneID" id="24563616"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202320"/>
    <dbReference type="OrthoDB" id="366500at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="27285" checksum="9278FC821ED11E49" modified="2014-09-03" version="1">MVYTSLTEAPHNVKEGIDWLVAVKGTDAEKNVKAMGAAVYELLADKPVGFTDVTALWNVKFATKKFLQQDEIKDMWPVKELSKRYYEFMDKSPEAIAKAPAMVPKSDYENVIKTRGLTAEVIGQNLGEVVEGCEKLLQGIKVPEQYESAYGSEATWDASCAAKPEACAVVFVGIAPMLYTGLGAMWDASHLEMSKKSAGAARVLQALGFVEPQCRARMTVSNALRGLRGIDLHILDTLYDLSGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBG2</accession>
    <name>A0A061DBG2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD domain, G-beta repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767271.1">
        <property type="nucleotide sequence ID" value="XM_012911817.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBG2"/>
    <dbReference type="GeneID" id="24563626"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202420"/>
    <dbReference type="OMA" id="YEAHELT"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1624" mass="182161" checksum="46ECC2AD1349C4FD" modified="2014-09-03" version="1">MMDRNCVSIGNCLFPDLRWRCDVTCTALSGDGSFLASGTRQGYVVLWKVRRRRQPRRRCPLSIRRFKEAYESTADVSLDPYFLLVASNNPIAFPVVQVAFASGSRPLSSLHHSSHRVISSYCGVEKAEEVLVSLHRDNSIAIWSLVDCRCLNKVKGPPFAIKRMCVLPDDRFVALVGRTKINVIDLWRIKLIGMLDLDGSCYFDKVTYPSRAHESAAGEAACSYLAMDTSNADKFSMSPRSAHNQPVYTKPRRILRAQSGLVPSDCPFALDDVTADLRHGPGPGDRADQITLISPILLSALLDNQELVVWDLTEPIMNYKQKHGVAGGPIAVVTRWDRQNEQFINLHRRPHHVHRGIFRGRHSPTKAGASSKGVVSKNGGVEADAEFPTLREWIPELKDAASDLVTVDRYVFLMLDVRILVWYYDTDGSLTRVAELLSLGADGVSIESPWRGFECVRVSQDLTLLAAWVDSGRVSIFSVPDVYSPSKPFQLVANHQLPAFITPSRSDECIHVHASLGSRHHDDLDFSKNASSSLRFRLFRRTSAGDICIGMPRHKSWLRICTSSLLSDCFSRHADGVVSSALFHDGDFLQRVDMLRCGSLSCTNVARGVTRELGSCRAIEECMLMMSGGYRLRPVALPGSKVMEWLAASPSANSASASHHTGRTLLHCLGSSYLVACTGASCMMVYSLTSFELSAVLCDFHRAPVTAVHSVFSIAFYGPKNTDAVLNEIEDTYLSVDRDGFLVLVQLPVLLNELSEDSLRPAIDERDIYSDASISDDDEPQCSSRGSFEHYVSLSSERRGIQRMQRSVELLEFPIERVALNRDTETLYVLTNRKILLWRITDGRFLRSLPYLATYRQAVWVSSGTTAELDRKQPGITLASTLTSFLTTEWTSATASPHTEEHHRLYLEHRQPHDLLAPCVFQEKCFKKRVSMSLHMSFLRMEFCVSPSSDSDVGREAPEDVYKRSSNKHPSRFCAKMLRQHGQPRHMHNLWRVTIRRRRGHVHSGFRAACSRFCRSSSHEANPRTVPTVSHSVPLVLFPLQKVLSHLSGSGGSLMPKLKDDGAVCYLGIPPGTVSIPLRYRKTKPDDSQPHVHRNLSVTTYFANDYLHKETRWPGIRRSFTFPCMFDERKIAAPLRRFSASKCNRYYSTCMYIRDLVVGFHANSKGGSYWEGSSDAWLLLHLLVLCTCKTGYALLSNSVLGSLRQLSCDDLYFHVCRALSALRCFHTKSGSRVPFPEMRVCRCHATTFSFGRRCGFCLQPAHFVDVGYASELAPPPPWQEDASLLLLVMITTDKRLSALCNYVCAGDKIQTFADYVSQLMFRHMLPVEEAPRASGDYPPEDRIFDPRAYCLEMFASGFASVWTLKSLDSSRILPASFGKNRVHALARSLYQSSDGKHLSSAQFVMSALSLYRSSRSEHWLSILRRCYLLDTSLMIRIIRWIVRERRVDKWYIETSVKLLLEFVTENRDRVVEHLPDVVVIVVRCLDPSDSSVRMLMLKSATSALFQLVKNFPMAAFYQDTQRFAVGSVSGHVVIYDLRTATKCRILGGDIKGVASLAFSSTGDYIAAYYRDPPCLVIWNCSSSGLLGTLLHSGKRDQKVIKLKRVEANPSTTAMVGFARFGVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM7</accession>
    <name>A0A061DBM7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0404505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770149.1">
        <property type="nucleotide sequence ID" value="XM_012914695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM7"/>
    <dbReference type="STRING" id="5866.A0A061DBM7"/>
    <dbReference type="GeneID" id="24566504"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404505"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404505"/>
    <dbReference type="OMA" id="FDRRDLW"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="37119" checksum="6489C78C322360F4" modified="2014-09-03" version="1">MDGNRRYARQLGMNIEQGHHDGLTKLFEVSKCNFPHHYIQVIEVCHLLGVRVVTVYAFSLQNFRRSAEEIRHLISLAVNSVDEGGAIRDFALRDSCRIRFCGDLNLVSEELRQLLAEVEADTAHFERYLLSYALWLNICCRITLNICMCYGGRSDINSALKKSAICEREGYKFSHVISIQSFALCMNMLYTFWFVCTACSSTCHGILFIFRIQAKFLMDAYLLVSLLCVSCCISITKHYPLHYFHLAAGDAPPPQVLIRTSGVTRLSDFLIYQCSEYTTFYFYKETWPNICMWSVVGAFIHKTLFDSYNRSTRSFTFFPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM8</accession>
    <name>A0A061DBM8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0406000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770302.1">
        <property type="nucleotide sequence ID" value="XM_012914848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM8"/>
    <dbReference type="STRING" id="5866.A0A061DBM8"/>
    <dbReference type="GeneID" id="24566657"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0406000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0406000"/>
    <dbReference type="OMA" id="GFCIHEL"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR98116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="397" mass="43612" checksum="DF5E6B6E4EF76AAF" modified="2014-09-03" version="1">MKLSSGLNSALTIIALFSAIWSPFNVVRCQLRFASLGNWGTGSKVQKKVADTLKSAIAKERVTFIVSPGSNFEYGVTGAKDEKWQKHFQSIYSSDDGSMEIPMFTVLGAGDWQGDFNSQINRNQQAYLTTQISENVETKGLPRWTMPNWWYHYYTHFATTASMSLLKSGHKDMSVGFIFIDTWILSQAFPYKDVSNAAWADLKKVLEIAPKILDYIVVVGDKPIQSSGPSKGDSQLAYYLLPLLRDAQVDAYISGYDHDMEIIDNNGLAMIIAGNGGRGGRRPVMKASNSLFFSEKPGFCIHELGADGMETKFINGETGDVLYTHKQAIKSRPQRQYGSEIQNVSAFPAVSLYPIGEMASPTQMDAFVKIVGTIGLIIAGIHILLLSGTTLGKATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBQ8</accession>
    <name>A0A061DBQ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770189.1">
        <property type="nucleotide sequence ID" value="XM_012914735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBQ8"/>
    <dbReference type="GeneID" id="24566544"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404880"/>
    <dbReference type="OMA" id="TWEILDY"/>
    <dbReference type="OrthoDB" id="433917at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="133" mass="15565" checksum="2AA0582B66CB75D1" modified="2014-09-03" version="1">MQRYALIPPLHLLGALRRLHISYSNRRLDTADIARRLVVYATGDKLKLKFPQLYVTWEILDYDAPAALQVEFLDGRKRRYLIEGYSKPERERLVDKWKFDAKLEPWPETLAPTFAKQDDKPNTVNGRNEGGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR3</accession>
    <name>A0A061DBR3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0302030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768485.1">
        <property type="nucleotide sequence ID" value="XM_012913031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR3"/>
    <dbReference type="GeneID" id="24564840"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302030"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="98" mass="11283" checksum="A97807EBE99F92D8" modified="2014-09-03" version="1">MGENATINNGSGCVQLIFLTYNLLFVKRRFLNCDRTSVIQCRIAHRSVKLDTSVPRYQFARQYDNIAICCGLVAYETPRGWTCVMKQCDDLRARMAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW8</accession>
    <name>A0A061DBW8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleavage and polyadenylation specifity factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0405580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770259.1">
        <property type="nucleotide sequence ID" value="XM_012914805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBW8"/>
    <dbReference type="STRING" id="5866.A0A061DBW8"/>
    <dbReference type="GeneID" id="24566614"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405580"/>
    <dbReference type="OMA" id="DNREVIC"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="7">
        <location>
            <begin position="281"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR98073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="736" mass="81311" checksum="25432AE9BD9E1129" modified="2014-09-03" version="1">MQAADTVYLNQADVAKSTNITVLGAGCEVGRSCVFAERGGYNVMFDCGLHPALSGVGALPVFEAIDLSKVDVCLITHFHLDHCGAVPYLLSKTAFKGRILMTYATKAICHLLWTDYARMEQLQTVKSIFDRSGPKSDQAGPDQKEGLMDELICGSGLYSFEDVEFALEKIETIDFHEEKDIGGIKISCYRAGHVLGACMFLVEMDGVRILYTGDYSTELDRHVPSAEIPPINAHLLICESTYGIRVHEERLQRERRFLRVVLEIVTRGGKCLLPVFALGRAQEILLILDEYWEANSNLQSIPIFYISPLAQKSLRVYETFVGLCGEYVKECVYNGFNPFNFKFVKYAKSVGDIEPYLRSDTPCVVITSPGMLQGGPSLQIFEKIASDNKNGVVLTGYTVKGTLADELRRDPEVVSIGTKTLKRKCAVEQISFSAHADYNQTKDFIRKLSVPNVILVHGERTEMARMRDKLTEEIPELSVFTPEVLQMVTLSFPPDVAINAVGQLADDIKEKMLNGAVGSDDGQLASVVIVKDSESKVMYADDIENCATMAINYLDQEMAIGFNGGLEQLKTAVGAVYDDVKVVSKNTIVVAELVTVIVTADRMTLRWRASPVADLIADSISMLAVQLIVHPQQSTEEAEMINKIKDEEVFFSVAEMQLATKFGQPTQVKVEEEQAKPNADKTLTFHIYNPLEENARVVAMEVNLSKCEVTCEDADAAKVALDIIKTVKAALQPINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC96</accession>
    <name>A0A061DC96_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769858.1">
        <property type="nucleotide sequence ID" value="XM_012914404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC96"/>
    <dbReference type="GeneID" id="24566213"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401640"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7835" checksum="C8D089CCE4464DC7" modified="2014-09-03" version="1">MCNDSITASENDFTPQQYKCKIKPQIDNLLYIVLKVSVSSRCRLFLLQLLKPFPSIHVSAQRIIIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA6</accession>
    <name>A0A061DCA6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0205930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767621.1">
        <property type="nucleotide sequence ID" value="XM_012912167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCA6"/>
    <dbReference type="STRING" id="5866.A0A061DCA6"/>
    <dbReference type="GeneID" id="24563976"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205930"/>
    <dbReference type="OMA" id="DSCDHVF"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="4">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="225" mass="25069" checksum="9F717584F4CC6E25" modified="2014-09-03" version="1">MHDPESGDTSDEIIELTEGWSVCNDDIYSIANQLLSLAFAVKYFGDDSSRSRLLGVCESFYSELGALGEQVEPRPAFNYDRVYEWLRRTLEDRSAAPESEDVLVDEDKSTLYAICPISRRGISQPVSQKFSYGDDSCDHVFDQTSIKELIRASRCTSVSCPVAGKCIMLLVTAYLPLPFPIHVHHVVLFSGSMNSKWYGMTVMEARDVSLQSPSPIARSEVHAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCD2</accession>
    <name>A0A061DCD2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768830.1">
        <property type="nucleotide sequence ID" value="XM_012913376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCD2"/>
    <dbReference type="GeneID" id="24565185"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305470"/>
    <dbReference type="OMA" id="DPLCHNG"/>
    <dbReference type="OrthoDB" id="363639at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="448" mass="49910" checksum="066D7BE9FCA74F89" modified="2014-09-03" version="1">MGPFDGLIASSTCLNRVKLLTSAGLEKLLVGEISGISSDCNILSGGPCYVDARASLYHVWKLMLESRLCEQLWMHVCDPFPVRHSRTFLRTLNNAEWKGFMPFSANLPPPYVRVNCKDSTLYHTGMIKKMVHQVIKGHCHKSVQLQGDSLPEIMQRRGHLPVCPTLMVNIDNDMCEVLANASGDIGERPWTTASALDARISPAAVSAIANKIDLIQRIRNNSITAIWDPLCHNGSLLLELYSIFRGHRLRAVDHVYPMSNFPLNVRNVYEDAYESCAPNGYSGAPLKLLGTDVFDKHVADAKACLGRYLNSPIHSHKRKQNKFTSSEGGEHAESDPDAENSAPSTESADGVTLTFSPQPMEEVDVSCGNTMVLTNLYYGDKGRRKEFLEAHRRFEEVLMRSPRALLQNVYVVATEGLRTRSRFSWEPELHFNNGGVLVSLLKLRGVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF1</accession>
    <name>A0A061DCF1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768860.1">
        <property type="nucleotide sequence ID" value="XM_012913406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF1"/>
    <dbReference type="GeneID" id="24565215"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305780"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="176" mass="20184" checksum="BC31B008F1A77EA1" modified="2014-09-03" version="1">MIIVPQQLHQINQPTTVRAFGHPTPLAKIKLESSSFAHSVFTAFHIITIRKAEFPVLTALNIHSPQLDGMDEGKLQSDSEWDVKCEKGDTCVKNTASVRWILVLQREWQNAHTRQEMHSLNKRYMGQAQQHKGAKSETVMVDPSMRLYRKLLDTNQILLRNTERVTEFSQCTVMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCP9</accession>
    <name>A0A061DCP9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0307130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768995.1">
        <property type="nucleotide sequence ID" value="XM_012913541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCP9"/>
    <dbReference type="GeneID" id="24565350"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307130"/>
    <dbReference type="OMA" id="NKGLMRK"/>
    <dbReference type="OrthoDB" id="364627at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="374" mass="41923" checksum="805D8D3102E9C7AE" modified="2014-09-03" version="1">MAADKGTGRRDASSNNNEDRMVPSALLQSADTHETRLHDKGRSRSGAYDHRQRLEGDVYSNDTELYMEPLASGQFSTIQDIYGQDHVATPKGRPNVPPMGSEDGSFLMNRIADHKEQALHYAAGKYGHLMGYNKPPKADQFGFPVGGDFYLPPPAQTAPSQPEISFTSWNPRDFSMYQLRAVCGNDSGNSTVDGESVEDSDEMVGPDGTMPPANKRDPIYTAISGLKWKAKSKKWVVRWDNPITNRRVYKYFSGLRYGFMEAHKRAKYYLEFLNASVGRLEAPSVGNPFCRRIEGPPKGKANKGLMRKLMNRNRTDAIFKPSNMMYGYHAQAPYSNPMKFETPRESNTPEQPMYRFGSSMNDPYCLAEATASGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCS4</accession>
    <name>A0A061DCS4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">-Mitochondrial substrate carrier family protein W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0404590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770158.1">
        <property type="nucleotide sequence ID" value="XM_012914704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCS4"/>
    <dbReference type="STRING" id="5866.A0A061DCS4"/>
    <dbReference type="GeneID" id="24566513"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404590"/>
    <dbReference type="OMA" id="DIWIAGA"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="109"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="196"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="300" mass="33491" checksum="D1B8854B77C8C673" modified="2014-09-03" version="1">MDHLVNVVCGGFAGFVADALLYPLDTLKTRSQLTRNLQVERRHMQRLPRYRSLYTGFFVLALGDVPSSAVFYGIYEFTKEVLSDRNISEFPLELRHAVAGLGDEGTKLPLPLVHLAGSSCGQFCSLLIRNPFEVIKQQMQAGLHPTSYATFQSIRRAQGYRGLYAGFFPTLMREVPFDGIQFMLWERLKTLESAKSSVLRIWPMGGCAGIATVPLDVVKTRLMTQGSSRMYSSATDCVCRIVREEGLRALFSGMWIRTAWITLGGFIFFASLELGKLKVRPLFRPGEDASLPQAPRAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCT5</accession>
    <name>A0A061DCT5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CERLI1-like PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767941.1">
        <property type="nucleotide sequence ID" value="XM_012912487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCT5"/>
    <dbReference type="STRING" id="5866.A0A061DCT5"/>
    <dbReference type="GeneID" id="24564296"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209090"/>
    <dbReference type="OMA" id="HSPRAQI"/>
    <dbReference type="OrthoDB" id="359169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056293">
        <property type="entry name" value="PH_CERLI1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23634">
        <property type="entry name" value="PH_CERLI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596223" description="CERLI1-like PH domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="CERLI1-like PH" evidence="2">
        <location>
            <begin position="225"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="344" mass="39367" checksum="F1EB824194B0ACC3" modified="2014-09-03" version="1">MLRWAALAITRACCRAAERCVCNSVGCVGSLIKKSVDCEPLASLYYYSGIHRHRAFNLLVEICAIEGAFVRQQTVVELIVGDQKVAMTALPTDPNGMIESVGSRGSVFISQRDCEVQLAFYRKHLVTKKHIATMKFDVDRDILSAGLPKSKWFILRVESRAVGRVKLSFHRIDANKSVVDCLVLQQSLLCMQDYRDEGKQVEIDLSGDGLLLYHEKLHLFSFALEGPLIAKEECASEMRYYKVMLVDGAWRWCYWSSKADCRSGRRPQGSAAILAISTVIRHPTNYTSFYVKHYTRERSHDVILKAVDRSRDIWTDALFLFIAETRRYLEHFENFDAYERHCMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCV7</accession>
    <name>A0A061DCV7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769100.1">
        <property type="nucleotide sequence ID" value="XM_012913646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCV7"/>
    <dbReference type="GeneID" id="24565455"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308180"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="77" mass="8262" checksum="11262074A62254D0" modified="2014-09-03" version="1">MNVLLPRSVLAALGVVKNVEVKDAHTVNNFTISVQHSANIMSAMRWDVPSVTSTDVNAGVAEEHVRSVPPVPPHLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCW2</accession>
    <name>A0A061DCW2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769115.1">
        <property type="nucleotide sequence ID" value="XM_012913661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCW2"/>
    <dbReference type="GeneID" id="24565470"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308330"/>
    <dbReference type="OMA" id="IDYNEEP"/>
    <dbReference type="OrthoDB" id="363960at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13907" checksum="1316C5E16C7BCD4A" modified="2014-09-03" version="1">MPRYDLFARLPLLAYVDRVHIRYRPGSRNSETCRRLLLTLMRPETSRRFPQLSYAYELLSYDARPEIIVHISPNIEHRFFADSCSLEDIRRAIDTDQYQAHLNHLRSRSLEASRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD02</accession>
    <name>A0A061DD02_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770293.1">
        <property type="nucleotide sequence ID" value="XM_012914839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD02"/>
    <dbReference type="GeneID" id="24566648"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405910"/>
    <dbReference type="OMA" id="IMPYFWQ"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52792" checksum="88F8AF1DD05169C1" modified="2014-09-03" version="1">MSSFAIVYARYAAALSRYNCPSAVKHFGTGSFLQSRLKTIRERAIEQQIDWIKSAHVLNSTTQNSGCSPRVHSLTRSRQVCNVQGTPDDTAAVAETSLKPLTGLFSGVLEKLELGGFGTISAEHDDILNINADCILVPVPPNLTPYSGFGMCIMAAIPQNNIIGLNVLERGGKKLIEALVKRAKVVVAERLKALDAVRSQFETSQKFEEAVAVAKTLNIGDVILTPPFGTTKATIIGFVITPFFWGMHLPVVNHISSENSTRDATLKLRFAFKTALEHINRMHIQTIVCPTLTDALSGYEPRNAAVAMIEEAYDVMTQVDAIKPLYGINCLRLVHRSLPEARQIANAIVAVAHTRRPEYKFDESVLKFCSKPRKITYKSHKVVRNSKRIHWLRNIKPFLWRNGLINVPPPLLVHKATGQMAMNQLRPVPFYKDRVTHVLFPLMRSSYKRLKMGSSGHWLGTAKQEPVYTQSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD30</accession>
    <name>A0A061DD30_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0309570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769240.1">
        <property type="nucleotide sequence ID" value="XM_012913786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD30"/>
    <dbReference type="STRING" id="5866.A0A061DD30"/>
    <dbReference type="GeneID" id="24565595"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309570"/>
    <dbReference type="OMA" id="IIICQHI"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="120" mass="13441" checksum="70E649CDBFDA45E6" modified="2014-09-03" version="1">MHRLKELTEAKVYIIGDEDTVVGFLMAGIGSKDGLGRTNYKIITAKVGKQEIEQTFNEYKDRRDCGIIIINQHIAEQIRTAIDLHSGPIPAIIEIPSKEQAYDPNKDSVTQKIKVLFGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH5</accession>
    <name>A0A061DDH5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769595.1">
        <property type="nucleotide sequence ID" value="XM_012914141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH5"/>
    <dbReference type="GeneID" id="24565950"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313120"/>
    <dbReference type="OMA" id="GQSMYTC"/>
    <dbReference type="OrthoDB" id="364998at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="367" mass="41922" checksum="3EC31A2BC30B105B" modified="2014-09-03" version="1">MSQLYIRRSRSIVNDESLTESVFTTPGDWDYSMNLAAHRKHRSEFKIECVFPSAGFLKQLLLPINPSLGGRNTAVFKVNALDYANNQMKSLFYIHLVFDPNCMMMQSMMSGQAMYTCVRVPKSRLLKYSITSMDGSDYRHIVDIAVPLQSLMVCLNMYSHKVSAGAPCYTPPQQEMVMSYDSDDRQIVLNGRCVSYAEYWHTSDIGQSMVCRLKTINLNPLQLPFDGSDFNFVDVDYFSISPKLLYPCLHDIASDSASSKLVLELVPPDETNNRCVLGLARGRSSMALEWDFSYDTNVFDEFNVHTQHMHTYSMRCWQGVTNGIKLARRIRIAIKDDGVLLIQVSMMDHISDGIYFYYQMHPLLDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDN2</accession>
    <name>A0A061DDN2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0303090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768591.1">
        <property type="nucleotide sequence ID" value="XM_012913137.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDN2"/>
    <dbReference type="GeneID" id="24564946"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303090"/>
    <dbReference type="OMA" id="ALHIDCP"/>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2979"/>
            <end position="3025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2979"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="3001"/>
            <end position="3025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="3599" mass="398693" checksum="E5AC82881AA94D4C" modified="2014-09-03" version="1">MFEGLVKRLLDTYLAPYVDGITQNLQLAVWSGNIVLENLTLKTDITEKLALPFDVHFGKIGRLSLTIPWASLGATPVKVLVDSIYVCIGGIERNKTDEELRSYVRLAKEKLIGVLENEYSAFLNSLNQRGNSTSSYLIRLSQKVLNNIQIDFTNIHLHCSDTQHAFGFIIDSISVRKFRKEDGKDVLKVDTSDTVKEERVTHVCSLLGFSIYERATKDSDGAEESDAESSRRDRAVEGAAGTVDSCENDVDDDYKRFDTPFEADPAGGSADTESPSVDDVQQPTGDAQGIASPSQTQRAETMLQKFSTGKLDCNFLLDKLSFRLFLAINVKNKSIFASLSVGAQDSSDGADSSVPDSLRVVLSVESLRAFVAMWNDFVSEHERSERLLMEKAYTVDQTPEGMKGITRTEYITLYAKKLNALHSGGEQLSPLEEERLAILTDVVSARHLARWRFAAHKLTAGAAAADSANKAPAKESSEPGPTSPAATTTTWFGWLRGLSSSSKKQTTATPNAVEDTPPGADAQGAQASDEPPTDAGGDTNDVIVAGDVPAIAEGGLQRSISSDSENPPVSARDTMNPGDVMLSDAPNEHRDGAPVFVDSTSTELPSSAMYPEYVEGAAVKGADQVECLPGGLVLTGEEVEQLMDAMALGEMFEDSMATSNYYFECALPHFDFVVDVGGLTGSPNDSLSVSTGNLQLQVYLNAAVDTSDRDTYNAYLYVNLDSFDVRYKNKVIMAFIKSEDVSSTDEEADVYDAQYEPAPVADSFAIDLRVVHKVTNQGNLLMVTGELKPMETHLIPVVISEFIEMLVYIQPNATRRTTYTIPPSVVDACKTPGAALDNISMVSSVDDEMWAAERNAARMAVDHLPALFAFDIKFAAPILMLYNGEGDRMNVRFGTLNLKSNGPCPLSNMSGTIELKETQVSCLRKNSGQTQWYNFLRPLPVKIHYDCDLVAHNLNVDIIFEELFMQSTPLDTAVVSCVLAEIAACLMGARASLRRDREVKPAVEVEPTKKTFDKIPFNLKAMIIFRHSGFSVSNTDGCDVFRLEVHNVSLELELSRSSFRAVLGLERVMVSNPAMDMPLFFTHLDTMPVGRSAWFNEDDDNEFEDALEETAKSLQVEVTRNESCQYRINATITEMEGNWQHSSVKLIIDTIEDYKQLYMAKVLNEHDKTQEADLPAEDAGSMTIGVASGSETSTPILKAVDASGGNAEKVGFATTQLLSDERASSSSVGEEMSSVASDTEAMYRFNSALIRGETVAYPTDGYVWREVEDCNIDLKELPTLLSEEERHEHKALITVSIKGAAVVFWNADSQVEARLSVSGIGYKLLKYGNGESISNLEIRTGKLTYGGRCLLSYTDTKTLEEGSNTDEPPTADKPLMTLRWKMYDSAKLGVPYSMCMRGALERIVFVYFQQDIVRLMDYLDDGILSVFISRSYHKVVQVAASTHMFYSFSVASPCFLIPENKAILPTASKDHVAPGSTLPNNVTRSSAARICVPIDTGDEFCAQMAKRLSGIVDTWYFGSYLLFELGHLYFRNGYTQRDDISRKSTIYLKMLGTRASIIEQTDGSTDVMGKVLQSTDLAVCYIGGGMLELGIDSDAWILKLTRTQLSFIIDVFNENICGSSYKTRSHVNVSSSAKPPFRCGIRLSLNRFEFDTLFSPEKPLASLKFDGITVCLNFGVDTVRMTSCYQFGLCGKTLTVDDERPNSVNVHRRLINCFVHDGDAACADLDDDARAMEPSVTRLLHNWLRQYKNSTGHDFFSNASSADIYGIKVVVVNENNQTGVDCMVANADISLLCIHAMDLLRYFTLSYSSSSMALCPKQSHSTQTVSNAKIYTFNFKATNGKFIAFTRMDSTSYPQLELSTDFFLEMTMQNGSFNFLKVDVLGCKLERVYPVTAKRQVLCSCLEVYGSGQYVSQPQGYKMFFNFTIPPSNLTLYTKDLSVILAAVTAVLTDGPSAAPPRDESDTAGDGAGTPGRFLSVSFNIKGIKVTFFDDMRKCLIPMMRLSVASENIEYMSLPIEKRYTVVRCSTRLEYFNAIIGDWEPCLERCNCSLEYTNNIGTDRNRRRQGRVLRPGSEDEWKDFIPNKVLKISSAHNILINITPSLCQLLLWFIPMLTNNIQRGLVYTDTVEEEADPQVENSAYRYVNLTGHDYYVFALQSTGDSTGGIKGLRVVEKSCVPQELDSVVSFVSTDNSSSACIYVIACPPPAQVTEICNELGIENREPIARDLMVTRNAAKTRANMVHSKSYLPSSYAVPFENGTVAAMVPLARNCCVSLKCPIEDLAGTYNKNTLICEVKSPHPSHKLLMFTSTVRVYNRSGMPLLLCFLDQKMNVMSVSSLKTRGAPISILDKGGPAGDEFGETTTVHFPESNVNYLRLQQEEVGYTMLLEHNHFGSVPECVFQGPAHAVMSFLPAPLAMNRPFMEAFFDRAKRQDASRTEAWMKLSNTSGWSKLIDSSRHLGTRVRQCYCPGFTKSSFLYYVVSVVKRKSAFPANVEMRDIVIYPALSVMNTLPMEIDVCFGANDRVTEDNASSSKKAGNYIEESLTLLRESITHIYSLPPNESLSFMAKICYSGSNVWSDRVTKIYGTSETHTMLNLPIKGMAPVEVELIRYPGGLPASSTSFQGHLSLIINAPWWFIDRTGLGISFQKRLPRAVMRGLSFLSSENQDDTLHLCVNRKAIDKVESNVRMPAVGGYAYTIVESGGKRHSVCLVTEKISISGLSNHVTCRITSAIPSFVFINNLKTPISIRKDSRTPHIVVEPGQNVAVPWVLSKTVADPASVVSNVAPIEFKTSDEAQWSSPIIPSESHSGKTYMCVKQDKSNKPLVFCISVVPKGGTKYCSIAYPQCNNEGFVLCNQCPYIKAAMVRTFHQGGDSGSKGNGVYFTAKYGQTVHFGWQQPFLNKTRLCQVMLWLDKNTVAPIKPLVINIGSPAFRYRQVEVTTPEYASNHAVLVSAENRGDYIAIDIKPSGQYLEVARTLNTHRSENTASTSSQPESGSLSRSRNSENGDNTPDHRHAGDPRGPLDLDTEILKNSEGILESNESEYDVGTDTRSMQIQVQLSQIGLSLVSHNLHEELFFLEMSTVSFVSLFNGDHQRLELRISDIQIDNQAEEKHADEDQCSTILVNRRKTSGQEHQRHFLQIYVDRPFASCKDLCLKKVFIALDDLEVDISDVLLTRVYNFYKECMKCMGNWGPQEKIDLRTIDSWVQKESQEKLSSLEKNPVPPRTLVLDFLFIERFNLVLWCSFDLEKLHMLGDLMRVGLRIICVSRHFELMGAPLQFQQENFCNSRGSIRSFYEEIKDKYVHAALSCIGSLLGYSSLLNIPKIPINVGRNTLEFAAEAVDSVSSGIGSLLSKFTFDNEYINKRQRDRMNKPSGNMRDSIVSAGKSIGEGFMSLTNIVTKPIEGAQKGGMGGFIRGLGKGLAGSIVKPIDKVGQAVSHVSRTIKVNMSRQLDGQRWSAEPCRWPRMLWGEYSQLKPYSLSDAEIKQQLGHKFSKHIVHCETVSKHSHPPSHIALLFYPSKVYYVDLKPKPTILWKASIADIQECRASCYGVIIRVSDTTLQVPCTNAGIVYSIFVALQNAKRQSKSSIVIGPELFESYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDT8</accession>
    <name>A0A061DDT8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768751.1">
        <property type="nucleotide sequence ID" value="XM_012913297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDT8"/>
    <dbReference type="GeneID" id="24565106"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304680"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7332" checksum="EDC1E8FE0C07BB59" modified="2014-09-03" version="1">MAALEKSSSVSAEATYYYYALSAYRLPPNAETGCGIHVGPLPILTGAVHASIQNRVHPVWAPGLFTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDV7</accession>
    <name>A0A061DDV7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ALDO/KETO REDUCTASE, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0305180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768801.1">
        <property type="nucleotide sequence ID" value="XM_012913347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDV7"/>
    <dbReference type="STRING" id="5866.A0A061DDV7"/>
    <dbReference type="GeneID" id="24565156"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305180"/>
    <dbReference type="OMA" id="YNLLHRN"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="157"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="818" mass="93066" checksum="FD84F8C962724D6A" modified="2014-09-03" version="1">MVPGRELTEEEIDRIFDNLFSNPIYEAREPDTPPEKTGSATKNENRLKGLGTKHYQGILDEIRTEVAVRVRREQGGKSQTVDTNEDVEDTVSSAVSDSAPPTTASPLPVDTAASAAERRVKFVARNNFPTAKVLNSKHYVEGLKFRRLGESELVVSELGIGTSMYDNPELIDHDHAVEVLETAHKQYGINFYDTCEYDPYPYEPRSYLEGQHRSMREFLRRVKREDVVVSGRISSSNLGKFRTRGRFLSWVRGDISSPPTLSVIEKAVDKLLDRLGTDYLDILSFVHPYRYVPNAHLGEDTYCWGNERDVFSGAASENADECTYDADELLSAQCEIFETLVSKGKVRSIGLSNETVWGLCHLKNKSGRKFPVACTQQMYNMLHRNEVESSGMSEAVLKENLNCPIVAYGILAGGILTGKYIDPERHNPMGPDKTKENATFADKHDYPGDYQSCLILISVEIPEDYGHLSFGPANARCNLFPDTFHTHRTIWCQHATAEYLKVARTHGMTLAQLSMSWVFSRPFLHETIAALNYPMTREIENDVHEIFLRYRAPTMGGPQLLTRLDDDFAVPMSQNDRMRKGAVPIWSGGSHWDMDSIPPISRIAEERKHDEAYVETASLFGLFDKPNDECWRNYRCWVERTSEGLPGEYFAVKESKLFGWDTMKLDEFTVVPKTPEEVARDDTSDFHFYWKGGQVYVGPTSDAIRAFYDDQIAVCNVMRAREDSFKRGLEVEELPEGCKVWSSLDADLVFKRLRDKFGIDVTEPRLLERLLLDCGREVVALSAAERRCEKFAYFEDREHLLKQEVEVSDVDKRRTTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE73</accession>
    <name>A0A061DE73_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BBBOND_0405180</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770220.1">
        <property type="nucleotide sequence ID" value="XM_012914766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE73"/>
    <dbReference type="STRING" id="5866.A0A061DE73"/>
    <dbReference type="GeneID" id="24566575"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405180"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595748" description="DNA ligase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="572"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="48"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDR98034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="841" mass="92902" checksum="892E37B3CD825E5C" modified="2014-09-03" version="1">MRCRIAAWLFALIFFVSALSDSCKCFRLSQSSIISGPMNIKQFFAVQPHPARSTPTSPPAGEQTVPARNDGSSSNEGLNGPGCDITAASPKRRIGAVSDATEEATIDEGLSWSQDDPSESVGDSAVASQVSECAPAEVGKASKKPKKSPKRKVDADEPAVGTLFNRTMKPGEGCADIRSAKFDPSLFDISPYIPKYPPSVQQNSLLFIFLAEILQEVDDMFRSGVGSRKCVSTILSNFFRVLIYHSPSDVIHSVYIMINRIAPEYEGEEIGVGDVLVMKAMAESYGKSEKSIKEMLTKHEDLGIVASMSSCTSQTIVRLPDLTIEGVIKQFKALAAESGKNSVERKKNGIKRLLACAKKKEAKYIVRFLQQKLRVGVNSITLFQSIADATYLTKAAKGDQPAIGDVRTAGIKQADTIEEMEKAVKTATTHLACIETIIGHLLDGDNCQQLLEHCKIRPGIPVSPMLAKPVSKTAEILPAIGGPGVAFTCEYKYDGERVQLHMMEGRKVRIFSRSMENICEKYPDVIESFLICVKPTVMNCIIDLEVVAYDPENGKIMPFQQLSTRKRKGVSVKDISIPVCMFPFDILYLNGESLVTKSLSERRAALESAVSERKNLLSFACRKDMNSLDEIDDFLRQAVSDSCEGLMIKSLHQDATYEPQIRTNNWLKFKKDYIEGMGDSLDLVPIAAFSGTGRRTSVYGSFLLAVYDPVHEVYQSVCRTGTGFNDQMLTDLHDGLQEHIVAHKPAIYDVPASIEPDVWFLPVRVWECKAADFSLSPIHTAGQDFTPSKKGIGLRFPRFIRLRHDKAPVDATTSEQLYEMYAKQFNKTLFKEKNTSSSFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEG2</accession>
    <name>A0A061DEG2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0311280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769411.1">
        <property type="nucleotide sequence ID" value="XM_012913957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEG2"/>
    <dbReference type="GeneID" id="24565766"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311280"/>
    <dbReference type="OMA" id="CVMLEQQ"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="583" mass="64517" checksum="0B8B983A8822EAAB" modified="2014-09-03" version="1">MDEAEPSSESIHEVISEVGHQESAVEAEPSADNAPEVDADEIEGVDGSEQPSHVQEVGVVDGSEQASHVQEVGVVDGSEQASHVQEVEVEEPLGQQSVDMEHPSEVVDQMQFTSAQHAPTVFVDDLSETVDEMQFGAAHHAPTVVLASSSGEVDETQLETVRHTPTDIMEDSSDIIEGVEAGDSHDQGAAEEVPETSHMEEMRVDDQPGGNDASEATLREIEQKLAEKEQHCVMLEQQLIQANQQVETCYYQLEENGERLRKYGSEVEALKAENDRLGSEVDKMKADCERLELLETEKRNLSEMTATLTRDMEAKEREAALSLQSATALEERVKALEGDNTSLKGQLQSIESECQAHKLKSSEIYAMYQQLQKENVSMVEQLKQRSISATASVSVDTAAANYKELTGELERATQRCKEQEALLNSKQAAIQKLEQELAALKRERREAAAQAQENESAAASDADVRRMSEEFRMMKMSNAGLVSEVASLKAMLAEKTSRIDNLNCELLALRHPEEAKHKGELDLEDYMSNRRMGFSSNVASRKRRGLPGFMDALRLALGHWFMRLLVGMYILLLHVAVVVILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEK9</accession>
    <name>A0A061DEK9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin conjugating enzyme E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0313620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769646.1">
        <property type="nucleotide sequence ID" value="XM_012914192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEK9"/>
    <dbReference type="STRING" id="5866.A0A061DEK9"/>
    <dbReference type="GeneID" id="24566001"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313620"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="164" mass="18912" checksum="956A9869BD218920" modified="2014-09-03" version="1">MVNIAREILRRQYIELTRDDNCTFSVGLEDDDLFQWRVCFEGPYGTPFEGGIFTVVITFPDTFPNNPPQMKFEQKMWHPNIYPDGRVCISILHPPGMDIFNDQEAPEERWRPVLSVESIILSVISMLSEPNAESPANVDAAVEFKNDPQGYKRRVQIFARNTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEL8</accession>
    <name>A0A061DEL8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769691.1">
        <property type="nucleotide sequence ID" value="XM_012914237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566046"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1638"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1700" mass="190386" checksum="B43B987DC7A01CF1" modified="2014-09-03" version="1">MGFLSGVLEGVKNTQTYNVGKNTLNSVSSVINKHLCSGHDGFTKLLPRLTREVEKYNKEVRESNKAVSEPINELIKYVKDRGELLGSINKYQVTDNIEQDVLDAAEKTMAEKLKECQKKAETFNSVFNLSTQTDMKNAISYLNSTLSERVRVALRAVSHETERLKTMSGKERKDLDGLQAKIQSALSALGNCVNDKIQKDIENLVKQLKEGVNTILKHLKDIDGRLRQYVQKLEEWMESAKKEIDRIRNEDVKKILDETTDGVTGTKYLIEKDAEKLIRWKESLSDEIQRVKKKLVELVQQALKEVATMNRAVQMDLYLVSVAINDEIRKYVSQYVKKIQAQILQITDQRNGLQGVETKIVKEYAERFKEGSQGFQAIVKEWIDGIFKNNGLVKQSLAEYIRMSKKGGYTLKQEYVDVNAATLTQDKSLRIATAIKDALDISIENAQIDGDKKNNVEGNIGAVHDCIIQFVVQLNDKITQGKQDSGDTNKLVSSLVDAFERTVSQNGDTHSTARSYLIPAMAAVLSALYSKANQAAEELQSFTGDGEGGDNIGKNLDTALDVALKLNAGLTTALTESGQHGYNTAKPYPGLGPIELDANIAMTINRELEELLPQAKGSDGREDAKIDLEKVRNFINYPTYVKQPKTSTENPSEGQLPESIGAIKEEAAGIYITHITDGLTTLSSDLTKHLGVIMDAITTTTDRVKSKLDDFKNKKIGNAAHSKPAQKDTLQELHCKFLELHKYFEKNALKTAEAFAAYADRSGKNIIDPLKQHVNNEVKKAQDSIIAEAKKNYISSIQSLLQRFASKVHSELETLPKSIEDDLTLGFKGFMVKFEQHFVDTVKHIQNISSKSAVQTTEKGRKIYPFSQAVLKLRTAFSSLMSHLESQEDFTSDFERVKMANSVLVNLLNKLATSQHYDHTFSNDLDELKKVIEGFKPSTYGEAKCPLLLNTLKNGFTTLVSELDKAYISAYDSETFSDDLVKEDNTLTKYGKYYAKVFLTALRTLDVSLYGLKHECKSLTGQKINSSTDLGRLFVRLGFKVAEENREHWELQNRTVISGQYVANRLTWRVSGANDNQHLKICESKKRDDDYLNVFDILRCLVTHAKQYFEVCHQALRPKSRLPCNVNEMLVWFTGLPHHPVYEELIQNGLSAPFENPSKQRVVDDDGLELTLTDTRVESMTAHPSNITYNSVNTALQHLCTKSRDLLTTVMGHGNAETVYAVDFHTNTFNLKYPTSGEECLQTILDILRRMLPPLRYLYYQCSLGTNHGGWAQCLYGRDIKTSKWPCKNHSTEQPKCHPTDEVTCQPNCQPTSPLMSYLGDCLIGHLPHKLTSIGCRSVCSTCPSVAKLGMPCVTPLGFRAFSGSTKTGRDIYEILRLLFGSGLVSSLLCLAPIPPSTLPEHFQFALALTHVLHNTKNATAQAVTTAFNTSTNEVSIDLYKEPTKLTGALSAAYGNSQSSHNASNHIPKSADMSSLAMSQSCMLAIEDNVHCGPYLQTLFCDTYYYIAAKHTNVYLSWAVYLPWTLYGYLKSLFDSYCSISCQDWGCSRCVDGISCRPGKHGDGYSCRCRSLVGCRGVLSTLYGYGFTFGDAKKLLSDDQRRYCRNLYSQLQNVLKSQHFTKLFAECDNFIWTIRQPFTYLVLALWSLSLFYLICVMVGRLDVLHIRSHLRSPSSHRITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEM8</accession>
    <name>A0A061DEM8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769741.1">
        <property type="nucleotide sequence ID" value="XM_012914287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEM8"/>
    <dbReference type="GeneID" id="24566096"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400470"/>
    <dbReference type="OMA" id="HSGANET"/>
    <dbReference type="OrthoDB" id="10550051at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600841" evidence="2">
        <location>
            <begin position="25"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="769" mass="83631" checksum="2CD85852AAD0F5F2" modified="2014-09-03" version="1">MKARFVFSTLLAVVAHHQVLECFAEQYEMHNGEGDTSLLNEPYDDSVRNEESGLVGSAPQDFPLYSSRNTSLKGKKSSAKLPESTMNRTSSLTNGRHILQKMRSKSAVMKSPSSNDNADEKKVFRVKKTVEILIDAPTSSAKGDGDAGRNMSTKSTVVEVPDSSRSDIDVTAEVPSAETQSERPVYDETVVPKSSPPEFGMEGDTVKNRLPQSAMQYEDEKTGMVREDEDGLLFNNGVKELDYSETMSSQKVEPTLEPDADGSATYETFPLSTEDGYDSQNAIRRSPVESDSDVYESSSGMVMPHHRSSNPLHPEDGTGDDEGHGRRDGSIVRGNTRVKHGYRLGGLNEPSNYFAPARYADNTHHRGLHKGGVKAHHRKRSTKKHYNKLGDEYLTNYRSELKENSPRRKKMARSDSTGDVTTEAAERSIDPESSSIEVDVIGDDNSDGDMTNEVSGVPVYPQMLEKEATVDTETANADVDEDTMPIEEDSDAIETSDSPKMESELSSDSSDTVDEIEPDEISDGTALRGLRSKGRKAPKKIAKPAKSKAPKKNKKKPVNKRKRGDKKAKRSKRLEKKRMARAERKRSEKAAKQAKIAAKKSRKEAKKAAKDVIVLENSTTDDVNVIAAPSETAAPKSTSDSPNDGKTGSDGNDPPISVKAIADSTEKATTSEENSADAGKGPADSATSDNTVSLNGSNKASVASFEDTSMSADDTAEGNAAEKDNTPDVESPSSDEGDEDEMSDSQEDLDEESEADDVDEDDSEEVTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN4</accession>
    <name>A0A061DEN4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0400770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769771.1">
        <property type="nucleotide sequence ID" value="XM_012914317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEN4"/>
    <dbReference type="GeneID" id="24566126"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400770"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="14422" checksum="0C815D2BB46DEBF8" modified="2014-09-03" version="1">MQGCGVTYESDELFKPETPKIYDADGQEMGCKIDIQTAKEAAFYCPAPYVLDPPNCFDQVSVNGELKDLSEISKSLVPSRTNHFVTLKLNGNRVGPGEKLRQSPPLECRCVTVKGIVLSTIQIENYYSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN8</accession>
    <name>A0A061DEN8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769791.1">
        <property type="nucleotide sequence ID" value="XM_012914337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEN8"/>
    <dbReference type="GeneID" id="24566146"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400970"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="6626" checksum="85F581471EA5FEBF" modified="2014-09-03" version="1">MPLSILRGKNVADAQCPGTLAVDPPRPKDPRRSPNFNFNPTLYYMTAYESCTALILISKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES9</accession>
    <name>A0A061DES9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769996.1">
        <property type="nucleotide sequence ID" value="XM_012914542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES9"/>
    <dbReference type="GeneID" id="24566351"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402980"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="6557" checksum="A9336AAC5D4BFD4C" modified="2014-09-03" version="1">MVVGLKEWLYLPAEFSGLRFAFTSPDEISALNTDERGANASKGIETEECDCWSDKSILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET1</accession>
    <name>A0A061DET1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770006.1">
        <property type="nucleotide sequence ID" value="XM_012914552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DET1"/>
    <dbReference type="GeneID" id="24566361"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403080"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="77" mass="9345" checksum="CDEFDE36CCE2169A" modified="2014-09-03" version="1">MGAEMRAALYEKRVPAQTITEWYPYLTAHTRFFFRRQLKWMNDTGQFNYYKHRRYDAHGLDRSVQQQLAKVNSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DET9</accession>
    <name>A0A061DET9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770046.1">
        <property type="nucleotide sequence ID" value="XM_012914592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DET9"/>
    <dbReference type="STRING" id="5866.A0A061DET9"/>
    <dbReference type="GeneID" id="24566401"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403480"/>
    <dbReference type="OMA" id="WLFGNPF"/>
    <dbReference type="OrthoDB" id="409619at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595769" evidence="1">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="84" mass="9453" checksum="F692AA2FDB93A06D" modified="2014-09-03" version="1">MSTAPGLAFANLTLLLDVPQLPAIFAANCYHNYRTYARELKLVLSGAEDLVYPFNRINVQDRYTNKMGRPRKYSSGPCPLGKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYW9</accession>
    <name>A0A061CYW9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765977.1">
        <property type="nucleotide sequence ID" value="XM_012910523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYW9"/>
    <dbReference type="GeneID" id="24562332"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101200"/>
    <dbReference type="OMA" id="EDSITHN"/>
    <dbReference type="OrthoDB" id="361525at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="414" mass="45870" checksum="803A846DFE3E8D4E" modified="2014-09-03" version="1">MNAPTSADYAPKSIDKRAQCSKYRIVWSDQRWESGANARRRNQNTDDDLIVGGDIDTPPGILHTAETPELQEFTKRMWNEQVPINEAVERLSLLDDTQKDGVINNFMRGTDAIKSNGDTIGDDSTGKTNSAEESVPDMLQEGLETAGGTSAGRSDVANNTAGSNEPKRAENVGVEQTAEEVVGYVAPVDYIDEEQYRKETQDQRHGTDGARGVDDDAFDSDEEHPTGIYEVNYAALTESELELVLTLIQSTLEDPESHEQILKELLAGDTGGLTEAQCREYFDRFRRIGDILIALSETVGMKPLDTRWIPEIQMRIRDFIAQSGHEVSSIRWTERDVIVALKDVVAEKEAGKLHEALAVYLRTDAGEGFCPGIKNVGLLLYMDTTGSYDDEVSKASKRKSKSTAKKRNSLSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZG9</accession>
    <name>A0A061CZG9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0101170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765974.1">
        <property type="nucleotide sequence ID" value="XM_012910520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZG9"/>
    <dbReference type="STRING" id="5866.A0A061CZG9"/>
    <dbReference type="GeneID" id="24562329"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101170"/>
    <dbReference type="OMA" id="LYANEQK"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="317" mass="35746" checksum="0D59C6674623747B" modified="2014-09-03" version="1">MENSLPALCAPDLPRMMPRFTCSVLKKPLLGYAIPHMLTSCTLRWHISRFAHTYKSLQACQSDFFINGYTMKPTLSDSGARGTLEYRGFFRDESGQTVSPWHSIPYKCPSSGLYNMVVEIPRHTTAKMEIATKLENNPIKQDVLKCGSLRFLDCPYYWNYGAIPQTWEAPIQYGADDPHMKGLSLVGDNDPVDAIDVSQTTMPFGSVVQVKVVGALALVDEGEIDWKMFVVRSDDPHFDDIKDFEDIDRFYPGTTTGVMEFFRWYKTPKGKPINQFLAGKTFVGRDEAVKVLEEMHDSYQKLLSGELSAGGLWVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZK3</accession>
    <name>A0A061CZK3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766004.1">
        <property type="nucleotide sequence ID" value="XM_012910550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZK3"/>
    <dbReference type="GeneID" id="24562359"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101470"/>
    <dbReference type="OMA" id="KRVHVWI"/>
    <dbReference type="OrthoDB" id="432990at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="262" mass="30165" checksum="C892CC93103B8809" modified="2014-09-03" version="1">MASRRGGNVTATTKTIYYHSAIGTHRLHPRPLKNILYPYYWQYKPVYRARNPRTPQYYWPSIDKYPWHSHQKRFPKPEDITISIFSDFARREPQIRTLFETLHPLPLHGVNCLLWKTDRRSANENYRNVHNDGHSDSSCSSTDTGRVVSVNGKFYVTDMVTRNNLCYMVKHVQFKLRPFKARVLADLYAVGEANGGRCDVATATLLRQNVSPVGSVRGEWRWSPPYKTGKGADGDAADVERLSVENPYLYIYGLKEYAATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZM6</accession>
    <name>A0A061CZM6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766039.1">
        <property type="nucleotide sequence ID" value="XM_012910585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZM6"/>
    <dbReference type="STRING" id="5866.A0A061CZM6"/>
    <dbReference type="GeneID" id="24562394"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101820"/>
    <dbReference type="OMA" id="SHMICKS"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="376" mass="42755" checksum="0052B0A858F4C1B9" modified="2014-09-03" version="1">MAAKSGGGLCFLKSSAKAEAAPKERSIKCVTCAAFFPDVADQKSHFKSEWHLYNVKRKDSGIDAMGHAEFLQLKERLVQMMELKNNELENKSKAKMLRRLKDASPVAKYRNQESSEGCEETCDASTVKSGVTSVPYCPTTCLFSGKKSATVEENLQWMAKTYSFFLPEQEHLVDVNSLLTYLHDKIYNKYTCLCCHRIFKSIYAVMHHMDQKQHRKVNDDDFLELAQFYDFTNTYADLIPSKAADESSCGSTADDDDDDWEDVITGTTDSNEAIQRLAYFGVVRAKITDCGNLALPNGREAVHRDVSYVYKQNLVVRSSYGISKSPAGFQFLRVSEKRQITRAEKQKRTRLDHVRLKMQYKSYKLFVPCNQIAYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D023</accession>
    <name>A0A061D023_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766377.1">
        <property type="nucleotide sequence ID" value="XM_012910923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D023"/>
    <dbReference type="STRING" id="5866.A0A061D023"/>
    <dbReference type="GeneID" id="24562732"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105000"/>
    <dbReference type="OrthoDB" id="365445at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="277" mass="31367" checksum="4C738D7C329D29E3" modified="2014-09-03" version="1">MGLFNAIKRLPLICVQQAFGLCCCILKLARWTTVSLCKRTRRFFEHVLTGIVNEPERVLIIGIRNAGKSALLYRIKLGEFIQTVGYNYTLICSVQVPTNSFIEEECYLCSVCLIPVDTCVHCKMNNAKGIHLQLCEFGIADEGDTVENHLRVKSPPLTNNQLQYASKVVFLLDGSEYPYRDATLRDIVKIVTQHNFFHQSPKYVIFNNKTDIVGSSTNCCLDFIQLQEHIKIRTLWVNGSALTGQGIVDALSFLLFDDPLKGILRENKQKEDLIQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0C1</accession>
    <name>A0A061D0C1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sel1 repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0104320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766309.1">
        <property type="nucleotide sequence ID" value="XM_012910855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0C1"/>
    <dbReference type="STRING" id="5866.A0A061D0C1"/>
    <dbReference type="GeneID" id="24562664"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104320"/>
    <dbReference type="OMA" id="MYAWETR"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1201"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136173" checksum="094DFF1B061DFB85" modified="2014-09-03" version="1">MEEVERSIFESWMVSRLAVREFGRFDMVEQGNGRLLRWGTVMVPRRLEIMLHLLNSPVLHESTLSNTDMPHGTMNHFQLLSTPLRVPAGGTAHVLAVALLRNDRAKLKQYEGFKRDSASWPTYLDNEAAYTYLWRVLSQQFKVYRQPLPYNGAQLKKQLIYCYRNYENEVLIFKYHVALDTSKHNKFARLISHWSVDKMPVNQDYAFMLDGLLAGADRSYYPEEMFDNIGHFSDFVSTFGTTDEKLLKMIMRRPLLKPRMTLDECLDAEAAHIAKITIRLAHVLMGRMLVNHGIPAFMAMRSRRHVWRVHGVLGTLRRIRAVVNEHLLSAPGDEGAQSLPLPNEIDEIEEILFESSKTFHPYWAMKNDTLYHTVSGTLNDDGSNPMGLIFDPNRLLQRLLNVKAENIDFQMVHDVLHRVTALSTPSRGRILFRSPDTCRIVDNMLDKIAEQYESLPAPVRSKLVAKCRCLLAFLYMFGIVSPNGRLELPGGWPRDIARSLAYITDGIGSSCGMCNSILGFLSGIGYPPVAENMYAWETRKTHLHSTVYQMLVTSGRAIRKRHTEYYDKTLLSYLSGHYKEDDASSLAVGYYLYSGIGAPSRLLDDIHVRSGVERSPKAVGSQCIEALPYVLDAAKSAMRTRMYVINDEGSAEYRSRRYAEFIKKLALMGDVDGLRVMGDFHFNGHEAGNIGIDVPRALEYWTRAAHRGEVISALTMANHLINLLNYEGNGDASPQPGERIGDDIIVTAEQLQLDGTSRADIERAAERYLNIAAESSNQLAAATARYYAARYGIGQPRDPTVAARHLQDAADRGDTNSQLLMGHAYAGMLSDITPADGKNVFMALEYYRRAARSGNIVAAFNTAVLTLHGYDLKYTSSIDRCKASFTYFQQVGRQAPLPAVVRALSVRAARHGDELGHALLSMFLSEMGDPQAHIEAANHFKNNHKLCYVGGEVTLVKTAGRGTTSNTAVIPSPPTGVSKSSEIGDAKKLMGQRKAGDGNGAAKKAGAGSDSGSSKAAVPGKASKNALAEMPKRSVGIFTPYVQNEESSVTSECHIFYARRSGHAAMGGSPLLLAEALMDRYPDESAKWVLEAKIRNEPKAAYLYATMLEAGTGVAQDCQASYGYYSSMTESREHTNKMLGFLCIQRTRISHLLHRWHYPYGWFVSNFYDAAVVPHLLAEDYKPCHFALPAIKPLETVSDKFITVTFAVAVLLSSLVYIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D112</accession>
    <name>A0A061D112_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766489.1">
        <property type="nucleotide sequence ID" value="XM_012911035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D112"/>
    <dbReference type="GeneID" id="24562844"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106120"/>
    <dbReference type="OMA" id="CYKTRIC"/>
    <dbReference type="OrthoDB" id="361691at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43925" checksum="EFB125BF69B9D7B7" modified="2014-09-03" version="1">MRNDAGKRQGGAEPSKAFKQQRTSNTLSKEEHLSYSASEVNTDLPSAVSETCGSSPLRERIRLNMRARFHLVSHFLSRKPTSNDVEEEKCEHEASDTILTLCKVLNQPYSVVLTSLVYLQMYRNASDRWRESLQPSAGSPRKMERHEQFLIAASCVLLAWKYREDDVRVNKSNGKIFEFTSVLYKVYVAQSKNSSSPPSVSRWMLQDEGKEILKLKSQLIEHENHLLHALNYHVGPVPLPHKLIPSYVRRFLIAIAKDLSDLQDLALKMDDLVGLLVLDCYKTRICLDYTPGEILVSCIFKAVSLLTVAGAYPRVLSPQLEHEGYLGHIKETEARLNTFISALGKSDITADRIAQCLNDMRRYVRPPRKGEVTRTDGNIGEREIKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D115</accession>
    <name>A0A061D115_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CwfJ C-terminus 1-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0106170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766494.1">
        <property type="nucleotide sequence ID" value="XM_012911040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D115"/>
    <dbReference type="STRING" id="5866.A0A061D115"/>
    <dbReference type="GeneID" id="24562849"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106170"/>
    <dbReference type="OMA" id="CETHMIS"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="380" mass="41505" checksum="D8C7CAC168D54CF8" modified="2014-09-03" version="1">MSSGQAPDSAPASEEAAGTADSSPSAKGCIVRVYNIPAEIDESSLQEVMSHFGRVRRCQVMLGESAHSAAEAFVLFKRPEEAAAAVRADEKLECGGCTLKISLWQGEFPPEKPSVAKRASSGGNSDACWFCLSNSACEDHMVALVADHSYIAIAKGPLAPLHSIVTPIYHYPSAAAASRSVLEDMQRLIDCLFDQCLKSGSGAIAFERYMPMQNPCAMHTQIQVIPVPLDRAMDAFNYVNSSEHFCGTRVERLGAEDPTSIACLEGKLDDIERSYFYLQAVGRDNETNRGFMHSHCLWTLGHRGGGRRIPITFGRELIIHLLPDSAADNIPCKNSEWSSLGRSWREMALDWRNCLTSRDSEAQLSRDLTAAIMGTDKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D144</accession>
    <name>A0A061D144_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tubulin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0106570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766534.1">
        <property type="nucleotide sequence ID" value="XM_012911080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D144"/>
    <dbReference type="STRING" id="5866.A0A061D144"/>
    <dbReference type="GeneID" id="24562889"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106570"/>
    <dbReference type="OMA" id="CGIQVAS"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="498" mass="55494" checksum="7BF6C0E4D9DB9618" modified="2014-09-03" version="1">MKEVLSINLGQCGIQVASCFWEMLANAVRTCSDKPTLDVEQVSSYFSDTNDNLTSDKMSAANREDYMSTLKARCILVDTDLGTISEILQRQHLHHIDSGNIVCGTEATGNNWSTAYCNYGPQYHEAMEELLSTNLEICDESFQYFNLIFGLAGGTGAGLGSYVLDLLSDEYGKVPRVCNVITEGTMAAVSPYNTVFCLKHLNDLSSITNLFSNEALSQQKIESSEQELLNTLKSKPSKEIGFNHENGLISSHLKEFGLATVSKNYPGFNMRSILNTLIPLPGLNLTCPSMAPKNIINEGATTETLINELVRPSNRISPIPQKIKSAPIAMAIHGRFNNDSFKYIKRLKLKHNMVGWNRDAVKISLPGVNYTEDASTKYGGMYGITNDSSISPFLQTSLSNFDRLYSKRAFWHHYSDVFGEDDFSTAREHIERLRADYETTSNFMMPPPHLLNETSLASLGVKVNNLSDKACTDVWNETPGIIESNKQYWWSLNGSPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1A3</accession>
    <name>A0A061D1A3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RIBOSOMAL PROTEIN L7AE FAMILY MEMBER protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766599.1">
        <property type="nucleotide sequence ID" value="XM_012911145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1A3"/>
    <dbReference type="STRING" id="5866.A0A061D1A3"/>
    <dbReference type="GeneID" id="24562954"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107220"/>
    <dbReference type="OMA" id="KKDTIRH"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="309" mass="35087" checksum="155A262AE355E387" modified="2014-09-03" version="1">MAKPELYRLNRTAKAVSVDKKTRKEIAKDSGKPASKPIAVIPKVGVSALDNEKISVSVPTLEKAIDALQARAAAERESRTRNLLEDPSGSYVYLQVFLRKVFTETHVRPLQIKLGHPIYRGKDVCVFVKDPQKHWKKVLTELKVREVKKVIAVDKLRKKYREYKDRRLLVNSFDLFLSDKAVAPSLPSLLGKIFMEKKKLPISLTLNRDGMRDRIEEAIQSTFYRVSHGNCSGVKVALTSMTREEIVANVLQVIEAVKKFHMRDEKFKSKISGIYLSWEGSESLCLYSEELEAVEDIIGAAKEKKSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1I1</accession>
    <name>A0A061D1I1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAJOR FACILITATOR SUPERFAMILY MEMBER protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0109540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766842.1">
        <property type="nucleotide sequence ID" value="XM_012911388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1I1"/>
    <dbReference type="GeneID" id="24563197"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109540"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="570" mass="63204" checksum="EC5C423D6D739E4F" modified="2014-09-03" version="1">MADAVDSASEAAKESETPKKIRPDYGAFGEVLYHLVSFTEGYEQQVLYLCVRTFESSLGFNKQQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSSTSKYSSILFLRFLHGAAFGCIYPVQQKIVADEEDEGDESSNSTFTRLHALNCIGRMLCAAITTEAAQNVLLGFVGWRISYIVLGYMWISVGIAIIYGLQAKEEVVSPYDSVNYFVTQLSGAFQAVFTSGTAFLSIFTMLIAEAPMCSLPYMITYLEYLGVSDKNVGIAILVTTIGGAAGTAAGGIVLEKIASLHTDYGEMIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYVEFAILGVTLVTVGGVDRPIMRKAIEDKYQASASALIQCISGISISVSFVEIFAYVSEKLLGYAPSTQTIDDMDADLKENNTEALRKSTMYMIVIGSLLNIACYIALIFTYKKERPIIEEKNKVWHKAVAEKQREMKRKKEEVAVEEKPSEVAIEMPTSKGGKVEIEVQPEEEEEEPVQKDAHLGTPRSDESEGLMSDEEERRRREENQRREDEITQRMREQRTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1K0</accession>
    <name>A0A061D1K0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 2, beta, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0103170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766183.1">
        <property type="nucleotide sequence ID" value="XM_012910729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1K0"/>
    <dbReference type="STRING" id="5866.A0A061D1K0"/>
    <dbReference type="GeneID" id="24562538"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103170"/>
    <dbReference type="OMA" id="WPDYTYE"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="121"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="264" mass="28631" checksum="65D2BC903629CA5A" modified="2014-09-03" version="1">MDDNMSLKREDGLSESFSPSAAHGPAEAATSSGGISEGVGSSGANVTVQNGTVRPAATEPPKYDFGEKKKKKTPAASEAAKAEFIDGTGKVFVRGHIYPYEELLARIQTLINAHNPDLAGSKRYTIRPPQVVRVGSKKVAWINFKDLCTVMGRSMDHVHQFVLSELGTEGSIAGDGQLVLKGKYGPKNIESLLRKYITEYVTCSMCKSPNTTMERDSRARLFTQHCEACGANRNPTVTAAFRSVNPIKSGFHALNRGERRKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1R4</accession>
    <name>A0A061D1R4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766774.1">
        <property type="nucleotide sequence ID" value="XM_012911320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1R4"/>
    <dbReference type="GeneID" id="24563129"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108860"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="116" mass="12673" checksum="51D0213E4CEB2F20" modified="2014-09-03" version="1">MSQCQCNSSSESCSGSSCTCCAGCCPKCISKDGCSQCKSRITGENKCNPSTCPRCKNKWFCECTCCPKKHAWICISILIVFITVVSCYYFGLLNITSQKLSNILPTSQRSSYRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D278</accession>
    <name>A0A061D278_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0105210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="8">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the 2Fe2S plant-type ferredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766398.1">
        <property type="nucleotide sequence ID" value="XM_012910944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D278"/>
    <dbReference type="STRING" id="5866.A0A061D278"/>
    <dbReference type="GeneID" id="24562753"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105210"/>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000014">
        <property type="entry name" value="Ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010241">
        <property type="entry name" value="Fd_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02008">
        <property type="entry name" value="fdx_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43112">
        <property type="entry name" value="FERREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43112:SF3">
        <property type="entry name" value="FERREDOXIN-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599955" description="Ferredoxin" evidence="9">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="10">
        <location>
            <begin position="80"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="179" mass="20338" checksum="F64530853C6EBD63" modified="2014-09-03" version="1">MRLLEAFSLLCVVVLNIHLVVNVTGERMLHHCTLPWQQFRVGYVTHCNRFRKYRMWSTSLVPLANDRRYFRHLRPSGLFYSVKFVTPQGDVTVDCDPDEYILEAAEKAGIDLPYSCRGGSCSTCAGKIVNGIVDNEEQSYLDNEQMSQGYCLLCTCYPRSDCTIVTHKEEELHASGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2I5</accession>
    <name>A0A061D2I5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0201480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767177.1">
        <property type="nucleotide sequence ID" value="XM_012911723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2I5"/>
    <dbReference type="GeneID" id="24563532"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201480"/>
    <dbReference type="OMA" id="NRTFGFQ"/>
    <dbReference type="OrthoDB" id="333966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="447" mass="49684" checksum="A949F8F14CB302F2" modified="2014-09-03" version="1">MSTVDVNVATSVAQANHPDLMAANAPVVDSTTQVSPIPRSTNSRGGGRSSNRKAPIPPPPRASPSSSSGYPGVSWNKRMGAWLSFYYDADTRRSRTFHPKYYDFDVEKAKQAAIEFMKSIEKHPRCSLRKSRRDAKNAAFLNGGYNFDPQYLDIPGRTRKRSAVNHLVNNEYKTRSSKNQMNMTNNQTSMSEMYDMESLKRNFQMTSNFLDPCYVGNSGSMDSEYVSANNALENNYLSGSFESQQDFDKGYQSPMTWPACQSFFGNPEYYMDSQNYSVPFLEGDMAYTSPSNVYSEGDLPYAGNSASSSQQVQQTEQVIPENAESQSQNMFVGNYEMSPTNEDAEIHMLMQSIALSPSESFDGLRLTTYNYGDGTSGSSGSANPQQAFNNGGNTPLGSPYLSPYVQTIYNQFPEDSELNRTFGFQNLILANEAQPSQQTQPVMHSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Z3</accession>
    <name>A0A061D2Z3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767327.1">
        <property type="nucleotide sequence ID" value="XM_012911873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Z3"/>
    <dbReference type="GeneID" id="24563682"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202980"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="417" mass="45418" checksum="BA1BB78BCAA58571" modified="2014-09-03" version="1">MVFNSLTEAPHNLKEGIDWLVALKGDDAESNIAALGAAIYNFLVDKPVGHTEIPALEKVKLNAKDFMGQSELRGLPYVKDLLTRYSSPVKKPTGLGKVFNNVDESDYKNVVQTRKMKPEKITQYVTEAINGCEKFLGKIKTPDQYESAYGKEATWEASCSEKPEDCAAVFVGIAPMLYAGLRSLRRASNVSPLQYIGIRKKPEVGGILTAMGYEESYRRSPLNASNVFAALQSVSHRTLVTFYDLSGFWAFYGSGKIGAVREEQPVEPVIPEAEPSVDGEGEQSVIPEAEPSVDGEGEQSVIPEAEPSVDGEGEQSVIPEAEPSVEGEGEQSMIPEAEPSVEPAGEEPVIPEAEPSVEPVKPEVDDVEQPVKIAKAAKVARSVKAAKKAAKKVSKKARQKKEKKQKKQQEQQESAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D319</accession>
    <name>A0A061D319_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767199.1">
        <property type="nucleotide sequence ID" value="XM_012911745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D319"/>
    <dbReference type="GeneID" id="24563554"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201700"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="9916" checksum="EF0125DF3656D4FB" modified="2014-09-03" version="1">MAIVSAVRGVVRNVTKTLNAVSRAKLPEEKTRLAILRNVKVVKRSVCGIFLLSFIWCVIIKEWGPYLKDATQSVTRHFQNVRSFTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D330</accession>
    <name>A0A061D330_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PCI domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767209.1">
        <property type="nucleotide sequence ID" value="XM_012911755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D330"/>
    <dbReference type="STRING" id="5866.A0A061D330"/>
    <dbReference type="GeneID" id="24563564"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201800"/>
    <dbReference type="OMA" id="VCLKALW"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="243"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="441" mass="50134" checksum="65378D066FD39E48" modified="2014-09-03" version="1">MTTFVPLSPDTEGAVSSAALGDWILSIIKVREPSKTADYYSKLLNLFQEVDGEQVIKDSFQLFELLLSGNEMVFAFLNDAMKGETTVIAIDANTKEEVEVRDGRGKYMAMQLQVKYNDALRQVEEYFTVLMYMLQLRFTSNAQIEKAGNLLLKAITMDDSCAELRLRLLQMLYNSVDPTLPLRVVVYIALLEFAARNDIFHTLIPVIQKLDDWMKDWALDNNTKIHICRIISEQLDKMGKTEMAYKYWEKRIACCDGPAMMTPENVDAAANFCIRSIKAPDVLYFDRLRTMPAMEHLGRTNYAALKELLDLLVEGNNDDLEAIVAKHGEGSLESMGVPIDICRWKIQLLTLATICQNEPHVPIARVQQQLRLTREQVEELVVTAITKGVIDGLIDQKSEQIIIRSVMQRHFGEQQLKQLHSNLMQWKGCINNLIAVLGTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D393</accession>
    <name>A0A061D393_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0202300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767259.1">
        <property type="nucleotide sequence ID" value="XM_012911805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D393"/>
    <dbReference type="GeneID" id="24563614"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202300"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595929" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="838"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="974" mass="108660" checksum="B72BC063B06CBC36" modified="2014-09-03" version="1">MARDTIHGSLWIFCAIWLYFIRGIYAIDCDFGGPRALLSNKALVACHYDLNIAYNVSASCPSRVNDTEYVWHPQPRGGRTIDLNTYVGENGKINSIAISEVMPSEAPRPLIWLESIPSQSILHLDLPSDELYVIKKRRLIYICAPKNLVLSDALQGHLDGLSGPRVVEIPWTSNTPLTDEIKQFGAGLGVLFLYRNSEHLPFQGCGSRPSPLFAPDNEVDIDPETGTRSCVADPMSESPIGFLCEGIVAPYDCMISLVDKHGKVVKAPRPHSHRTFGRQSPWVVSKYFSGFSLPPINGRCYCIDNKTYRVIAKIDIRPKTEYVCDIASMLKNKHAKNISGPWCSVVLHPGSTLTIKLPKQIVKSGTINRNSEEVSDTDYSTDALSQVPSAYEYEANILPHDLNTMRELNSYYDLESYDEILSPQTLIGDALELDVSQIDHGEVKLKYHPDMPLTSKGNQNSFFFHYVLKCRDEKVMERIRAIVKISLALTHEYHIIGCDRGPQSIFDPNISTKHCSVKSMGNGIGDVYECRSRIEKGFKPSGIHCRPDEELLPANSESKVYDVNKNKIVSIPVSLESSNPRGIPGFKVLKFKNLDRLSTYAFICVDKNGYETSRLVLERMYESMSAYNSPNQKLYNRMMQSMLFPPVKVSMFIEGFASGMSLRIRYAHMDRLTLFEGETMTLSCENGSDGFRVPNLLKVHNSQQRTLKWLPENPHEYHYTGNHTIDGLELSLTGHNDSIVTTPGGFSVAHHYATAKEHLLKITTRMDAVIVSKTSSRKLYVPMMFVCGKVPKSSDSSTITGEAPALGASPPSSPVVLGSSSEDTWHVVEVDIMVTDPYMHGCGVTYESTQFFKPETPKLYDAIGQNVGCKIDFQDSNEAAFYCPAPYVLDPPGCFNNVFVDGIVKNVEDLSDALVASRTSHFVTLKLESKRVGPGETLRRTPPLECRCVTIKGIVLSTIQIENYYAKELVTVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3G0</accession>
    <name>A0A061D3G0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM76B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0109150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766803.1">
        <property type="nucleotide sequence ID" value="XM_012911349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3G0"/>
    <dbReference type="GeneID" id="24563158"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109150"/>
    <dbReference type="OMA" id="WRSTSEC"/>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF1">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="30709" checksum="AED92F403378A869" modified="2014-09-03" version="1">MATREELRTGVKIAKGNPKPAEDFEPKSRSVWDKIGKLEDRGLCMECERRRWKTSNIQVCLDCAKSLKSLTCCHCKISYVNHKFCAKASKIYKRELCLSCASNWATHNCDPKLCRLCNQWSAWRSTSECDRCHDLLLKYGEPSKCESCNNNAAFDRGESARQRVNDLRLCFLCTCNYKKNDYYNRKLLMHMGQDAGSGKKVQRTSSAQEDSPTNPDLAKTKAEGAEASAETAAQREVADLKECIKNLKRKYAELQEENIRLKKRLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3K9</accession>
    <name>A0A061D3K9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766848.1">
        <property type="nucleotide sequence ID" value="XM_012911394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3K9"/>
    <dbReference type="GeneID" id="24563203"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109600"/>
    <dbReference type="OrthoDB" id="10326809at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28831" checksum="379E1B4D7AD19E1D" modified="2014-09-03" version="1">MVYNSLTDAPHNVKECVDWLIALRGAHPDNNLKAMGVALYDFLVDKPVGKMEVPALENVKKISKEFMEQKELKNMWPANELLKRFSKPMIKNNYKLRNIFTTIYDSDYKNVVNSKDATAETVITGVINLTYGCERFLNHMKVPEQYKSAYSSEATWESSCSKKPEDCAVVLVGIAPMLYTGMLSLFDASNPPIVRCRANTVSERLKRVLTALGYVEPESRNSLHRAYVRKALVNVNFELLDTVYDFAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D448</accession>
    <name>A0A061D448_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vesicle-trafficking protein SEC22b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">SEC22 vesicle-trafficking protein homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0205010</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767529.1">
        <property type="nucleotide sequence ID" value="XM_012912075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D448"/>
    <dbReference type="STRING" id="5866.A0A061D448"/>
    <dbReference type="GeneID" id="24563884"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205010"/>
    <dbReference type="OMA" id="FIYWRFF"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="18">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="19">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR95343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="239" mass="27055" checksum="07A7D32F8CAD6AD6" modified="2014-09-03" version="1">MGDLTLLCRASDGLPLVEIWEDRISPESLDLNSNEVSKVTQSIKINARMICRKLPPNSTKCSIMEGDVCYHYMVEGGICYMTVTSTEYPKKLAFLYLAELCAAFEKELETQRKSHSPNDPLRAIAKPYSFMTFDRTIHKIKANFKDPNSSKALHMINNSLNEVTNIMRRNIDEILQRGENLEDIGRMADGLKAETLKFKTSSKLLAQQSLLEKYLVFVIVAVVIIMCYYFAFGSTKGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4J0</accession>
    <name>A0A061D4J0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767679.1">
        <property type="nucleotide sequence ID" value="XM_012912225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4J0"/>
    <dbReference type="GeneID" id="24564034"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206510"/>
    <dbReference type="OMA" id="YTCDELS"/>
    <dbReference type="OrthoDB" id="366080at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37175" checksum="46B429D30C6C8DBE" modified="2014-09-03" version="1">MWNRFQGRQLISAFRSRFRRFTSLSFNRSDLSELKSLHAKQLGKIALDVSRCSNSDIHLWRSFVECCALKVDSFDGKDTLRVWKGICAFYRNYDYVVRDEDADFINQLIFRSHEVSRAYTCDELSQLAEFVCDFAATNSHFLEGATALFSKISVMFNLRLAEASPYGVVRLLVSFSRLGIRDCHLLESLANFICKSDGFSAHDLRTILTSYALSSYRNDALLKHATDSFNAHPGLTLNELAILSFAYATLEYCTADVHALFQRHLVHEGEGSGTGILDADGPQVDLPLFCSNLDRLGVKVPRTVIDRINIETLPSESFFKVTVRHKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4M6</accession>
    <name>A0A061D4M6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767188.1">
        <property type="nucleotide sequence ID" value="XM_012911734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4M6"/>
    <dbReference type="GeneID" id="24563543"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201590"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="125" mass="13819" checksum="251BAB5EDDED87A8" modified="2014-09-03" version="1">MSCDLYATYKVDCLRMQTGVGEDTLTQQLLDGINSLVAPSVISPYVLDPPNCFDQVLVEGEVKNLSDISQSLVASHSNHFVTVRLYSSLAGPYETLRQTPPLECRCVTIKGIVLSTIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Q1</accession>
    <name>A0A061D4Q1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydrolase, TatD family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0102530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766110.1">
        <property type="nucleotide sequence ID" value="XM_012910656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Q1"/>
    <dbReference type="STRING" id="5866.A0A061D4Q1"/>
    <dbReference type="GeneID" id="24562465"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102530"/>
    <dbReference type="OMA" id="CSDIFFE"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="318" mass="36289" checksum="4E36F6B9C6E0A3B8" modified="2014-09-03" version="1">MEDSTSCTPSYDFIDIGANLVDKMYKGVYNGKQRHIADLSGVIDRAKKVGVTKMLLTAGTLGDIYDALDICEEFDKEGISLFTTAGVHPTMCNEFIRNKFRKTAEQYMQALDEIIEKHRNRIVAIGELGLDYDRLNWCDKDVQKKYFEIQLDLAAKHKLPLFLHMRNATEDTMDILMRNKEKWVEAGGVCHSFTSDEASLQRLIDEGFYIGINGCSLKTSDNLEVLKKVPLDKIMLETDCPWCGIKPTHASSQYVKTVFPVVKKAEKMTGETIYNQRNEPCHIMLVLSQGFSFQRRQVAEVVHQIVAPEMEFKEFCDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4V0</accession>
    <name>A0A061D4V0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0202290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPPC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767258.1">
        <property type="nucleotide sequence ID" value="XM_012911804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4V0"/>
    <dbReference type="STRING" id="5866.A0A061D4V0"/>
    <dbReference type="GeneID" id="24563613"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202290"/>
    <dbReference type="OMA" id="HFPILRI"/>
    <dbReference type="OrthoDB" id="365629at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055428">
        <property type="entry name" value="TRAPPC13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23643">
        <property type="entry name" value="TRAPPC13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 C-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="364" mass="41113" checksum="21DC65D1FCD2C555" modified="2014-09-03" version="1">MSHNVAPNLVVMRLSQPSYECAAWQIIDASDALVALETESLDTVKQTAYTPTLVLPEYVNECFLGETLHLSILLSNSNKAACNNVKLKVDVVTEDAVQDPFVMEPLSGVTLEPHRKPYQTTISYLCNKQSQHNMTFIVTFTVGKRNYQVVKRAIWNVVNPIDIHFKSEKDSTGRPHLEATVTNICKHTLTVKDIKLVTPQDSTFQDPIYEQHKDVNGVCVLQPNGAYSVIFKNVKTTRPMQIKVFWHCYERGVGEINMPPIAYETIQHPGTVSLNDEFTIKFRVTNITKESLQCRLKFNQKQLIPLVVQVEDYLDFGGMAPMESKIIEVPFMSMEKGLHSIRGLEFCVMPDLIIPVTDLQVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Z2</accession>
    <name>A0A061D4Z2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0103430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766215.1">
        <property type="nucleotide sequence ID" value="XM_012910761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Z2"/>
    <dbReference type="STRING" id="5866.A0A061D4Z2"/>
    <dbReference type="GeneID" id="24562570"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103430"/>
    <dbReference type="OMA" id="REWTANV"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595980" evidence="2">
        <location>
            <begin position="24"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="43"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="4">
        <location>
            <begin position="324"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="682" mass="74315" checksum="074D78E9D05A9091" modified="2014-09-03" version="1">MSFARSGLMLFGVLAFSVHALTARLPRLCSSRPLALGLNRNHLYFNRLQKELANFRKDPPPNCTLEVFGSRSDIWIITWTGLPGTLYAGEKYRLKILFPKEYPLKPPVVYFLQPSPVHAHVYSNGDICMSSLGSDYVPTASVASFVLSIISMLSNAKEKRLPADNHLLLVTMAAWTATTLCQRQVACALKTLAVILFFHLHLVKIAVAVSDAHQFRPGILTAVNPGNRTSIPSLEYLGLGYDVVEKAHKDALGSYNNDGSEFKAPIVRLVWPESGSRRYNNTLRWKLPRNVYAWRVPFYSIRENTANSKYTKTFSDQLTANFEAKSGPKPPDDGNTDDEVATDGEVAADDGNTDGEVAADDGNTDDEVVADDGNTDDEVVADDGDEQPAGEDNDALAEPDSAGHDEVAAEDEYYDDLFASLLDEGAASADSPYIEDAEDDPLSLDDDPETASSEDEENPASDEASLSAKLSIGNSASAESSKSQLSRQETCVAFVAGVLINRTTFDMAVIHLLRALGRHDACTLRHYGHARCGAVRMIWFDFFRQWGTHAITRITLGGEVTLITQKSQSESSGGKQNSAALSARAKAINAHVDAQRSDVQASSAADNQSSCAMDMLGGRPQAGLDRGELDTAWARTTQFSPMPIKMELTPLAFVFKPLGHEHHYYRALALYARNGTGTSSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5E7</accession>
    <name>A0A061D5E7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0210860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768122.1">
        <property type="nucleotide sequence ID" value="XM_012912668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5E7"/>
    <dbReference type="STRING" id="5866.A0A061D5E7"/>
    <dbReference type="GeneID" id="24564477"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210860"/>
    <dbReference type="OMA" id="FCIWPSP"/>
    <dbReference type="OrthoDB" id="6049624at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000004">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="51"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="250"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="440" mass="48483" checksum="89C5C66A98064F0D" modified="2014-09-03" version="1">MREVIAVHVGQAGVQVGNAVWELFCIEHGIAPDGTTENKEASGSGDEDKAFHAFFAETASGKHVPRCLFVDLEPSVVDEVRRGAYSGLFHPEQLMSGKEDAANNFARGRYTTGSEIMNPAMDRIRKLSDACDSIQGFLFFSAVGGGTGSGTGSLLLENVGAEYERKTKLNFCIWPSPQVSTAVVEPYNSVLSTHSLLENTDVAVVLDNEAIYSICKKNLDIGRPIYKNLNRIIAQVISSLTTSLRFDGALNVDMNEFQTNLVPYPRIHFMLSSYAPIISSRKAKHEFMSVAEITNSAFDTASMMAECDPRLGHYMACCLMYRGDVVPKDVNSAIGHVKSKKAVRFVDWSPTGFKFGINYQPPCVVPGDDLAKVSRAVCMISNSTSISEVFIRMDSKFDVMYAKKAFVHWYLGEGMEEGEFEEAREDVAALEKDYEEAINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Q3</accession>
    <name>A0A061D5Q3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766460.1">
        <property type="nucleotide sequence ID" value="XM_012911006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Q3"/>
    <dbReference type="STRING" id="5866.A0A061D5Q3"/>
    <dbReference type="GeneID" id="24562815"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105830"/>
    <dbReference type="OMA" id="WVDCEIL"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1201" mass="133462" checksum="2FC119993C76B665" modified="2014-09-03" version="1">MGVPVCSQASLFERLWRRYNGSCMLVKATASAREAIAAGGFKSCTQLIEEALDSDTSVGEAAKHEFDCEETLEEGDLDTHLLNVIADNTPDFCAQDIDFDGYPPWFIQWALTLATIARCARNKTLDIDPAGRGIMAFCTSTEDVENVTNMLKGSESTTFRCLVVIGETNSDEFMDRFKSMYQDLNHHVINIDDKPLRSCITDTAFLAFISKMVELYLSGMRAADNQLKDTTTAPNVPSKTAKGKPANTDTCDVRSLLLLMNSELQSTEATGYIEEVCRGTEQEIQGVALVYSAVLHMKAVKNASTSHDNKTDDAVENPITADNAIADLDKAISIFQKYGAKWDALLTAILMATIGGDLEARRLGSISATMDLKSNADYARAALSLELCTFFTDKLRKKMFHLVMAGHLYLQAGLLNLTKRCYMLAVPLYKEKGWGLASDFLYGTLSRYDPLYCIDALNGLADRCEMINCHKYMKNYEDDFLKSPWYSGEREMTHLRRLMKLSVAEHGEEAIKNKNSAAVVSCAYGPYPALVYGRNDGCPLGESLPYLVRVPVVLLRNSQGVPGQNCGLLRMSALYCAGGDIRETSYNTADDFEEQESAINKEVKKKAEANDAWKPYYEFITDYGNISYRVDPDSGYTLPKKRTKPATNYQSGEDSVIKLELVNPLHIGIHCDDFHVLINGANKNWWEKATVISVHAGMAEVTQSKPKDNFVYLSEGERRHVYLRFKVTNPGVFQVKGLGWKLFGCVSCWVPLYLCGQRKTKGAPLDHKEAETLETYLEGRLNHAGLSLSVRDYHPEVGVALSKVTRLPSNARPLDEDNEHFNNVKQFMSACGEGGNYAFEDGYLTMDDAIDGEFVITELVIKNLGDIAINSATLNVKTSGRCRLTNRPIAYSAESRDVRVVWEDMARCNLGSISGHKSYQVTLQNDSDLLISPKGTLSIFMLVVPRVIDGPEVICIQGRLKTSSIQHKSEGHVAFWRFYGADRGINVCYDFDHSLPKIIRCHLANNSKKDVKSLSFYDVSGQPLQTRVRSPTYMQTFDAIGLRKGSQLSSVIPFNPEDAKLTLRWECGHAFGVITSCINIDSSARVLVKVRSETRNMKYKKAPMLARVEFIFENPTDQTIPSMQLEAMPNRPAECHHKWFYVGSLTAKVPAIPPKCSKSVSFDVLLPLPGVYLFAGGCVNIAAASGVFLRPCEQFMVSVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Q9</accession>
    <name>A0A061D5Q9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0204950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767523.1">
        <property type="nucleotide sequence ID" value="XM_012912069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Q9"/>
    <dbReference type="STRING" id="5866.A0A061D5Q9"/>
    <dbReference type="GeneID" id="24563878"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204950"/>
    <dbReference type="OMA" id="AHMNSFY"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="24265" checksum="820F9B0ACAB08579" modified="2014-09-03" version="1">MTSLGVWQLKSVLLRYSETGHSSRGLRFYMRHLLETFKWRHPHVDVKTQHEQYELPSALFSYLDGSKYDISLKDLEARHIEEIMTLHSNSAGGMEYMKHGQAKVWTTNRSIQGLWKPTHESQAVALAWFKSKDSLCTRRKITTRSLPKYSSKSLNLNCEAVKGNGRWGDETIFPRGFDQQYLKDIFTMPLINPEALKRQAENQKDETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5S6</accession>
    <name>A0A061D5S6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768257.1">
        <property type="nucleotide sequence ID" value="XM_012912803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5S6"/>
    <dbReference type="STRING" id="5866.A0A061D5S6"/>
    <dbReference type="GeneID" id="24564612"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212130"/>
    <dbReference type="OMA" id="ADESDCA"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="1">
        <location>
            <begin position="145"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="726" mass="81353" checksum="3D7AB94B89219996" modified="2014-09-03" version="1">MTDLLKSLVSRLERQEEAILAELRDMEAPTMSSLDGCKEALRTSEIAQKAFSLNDNFERTERFSERLLTAADTSSLALAKLECSLKVVDSVSQLYELGSRVLSSYESGDTKRGGEDISRFVAVMEEAKRDGHWDELLKVISCGHVKEVMSGLRAFVIEQLRAERPSEHSQLFTRLAVTLQAGSEAYESYLKTIREKTIGIGSASHEGSDRVKLERLVKNASSLLLGKAQAVHSELGSADYIRICREIHSLTSTEACEILRSFLLSDFAHFIKDPEGDIDSLLSQVESGFGDGNLFGAFLVDLKTVDHVLDNIATLSSLWLDYEFSFRSVLGPVYQTLLIQGDLQSEFGNDCLGSVSAATRAMQSVLSFYVRLEHASVTRALMHAINCDSIYVSSPEDGFTVATSTLVDDSFFVLQKAQQRAVATGDVQAACATLNQVIGIIQSSLKEGLVGNLLASQNIYKVFIENADNLVNGSWYVMLQEHFERCKQPFPESVPSRFSFIHCVNNIEECVNFLGKFKFEISASFEREFVQLDNSKLLVESTLESLDGVLGEFDELLELACKCSLNIIKFHIADPLNRFNDINFNLDEESYTTYLSENPFVEEFIVVLRGVFGHLSTFYSPTTRSRCMDMLIERICKFMEQNVLAKRFTMYGAVYLDGVVRSLMKLCTSYDPQIRHQFTSLLLISDVLNCGSLEELVQFEGQQQSEYVERYFALRTDIPSETPDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5T1</accession>
    <name>A0A061D5T1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0210645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768099.1">
        <property type="nucleotide sequence ID" value="XM_012912645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5T1"/>
    <dbReference type="STRING" id="5866.A0A061D5T1"/>
    <dbReference type="GeneID" id="24564454"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210645"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210645"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="78"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="167" mass="17797" checksum="8F7E7A9CC6276365" modified="2014-09-03" version="1">MTNRVVLPGFCLGASAAKCADDNVHVRNTLIHSAVLGTATVNQDSKDGVSGCAAVLPHRFQVPTIALRTCATAAPAVGAIVVAQVSKLTANQVECCIVCIGDKPVPEGLKGVIMSSNIHESKAIDSTVYEWFRPGDFVRARVISTKRMVPISWKFFLGYKSGVVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5V1</accession>
    <name>A0A061D5V1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767578.1">
        <property type="nucleotide sequence ID" value="XM_012912124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5V1"/>
    <dbReference type="GeneID" id="24563933"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205500"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="97" mass="10852" checksum="94A21504ADFCC224" modified="2014-09-03" version="1">MSIINNHGTLNLPRIQTAIALVIAVYCSSKMSQSELCSDWSHWADVSSVKNDFAIAYEDMQSASDVVVEVNDCTLLNLDPMSGKYPQRSDKERRKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5X4</accession>
    <name>A0A061D5X4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiolase, N-terminal and C-terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0205750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767603.1">
        <property type="nucleotide sequence ID" value="XM_012912149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5X4"/>
    <dbReference type="STRING" id="5866.A0A061D5X4"/>
    <dbReference type="GeneID" id="24563958"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205750"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="267"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="385" mass="41003" checksum="7BE1636C76F71699" modified="2014-09-03" version="1">MSYIIGLARTPFSPVLGALVEESSIALGATALNGALSRSLTSRNRIDRLVLSQVFSAGAGSSPARQISINTGLPSSTRCFQTSQLCTSGLKAISIAKDALDLRKSQLTSVVGAESTSQAPFLLTKARAGGYGVGDDVLVDSVTSDGFTKMGIDVDSFTKNARISKLEMVQYAAESFRRAAACYSDGIMQIEIAPVIVKNKRSAAREGEAWISHPHTKLVEDTLPRHFVPKHASASTIKTKSTMADGACSLLLCDDGFLRESGATPFARILDCCELSTDSDRFPDALTDVIRECSRRVNSRIDIYDINDQYAFLPIYVAKALNIDHSRINVHGSTIAIGHPMGRCATGIRQIISLVTALRSQGLQYGCAAGANAVGDAIAVILEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D636</accession>
    <name>A0A061D636_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="13">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0211660</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="13"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768209.1">
        <property type="nucleotide sequence ID" value="XM_012912755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D636"/>
    <dbReference type="STRING" id="5866.A0A061D636"/>
    <dbReference type="GeneID" id="24564564"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211660"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="754"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="503"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="627"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="825"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="631"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR96023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123423" checksum="59C7A731479B5870" modified="2014-09-03" version="1">MAKEEGRRLKRGLSLVHPSNHSYYRFLLSELERWRRIGNRCKVSSLNRAVNALERYPMPIYNTDNAVAMSGVGLNTTKVFERAIEKHGVPVVNRTQCAAYVETVLGRIRSFIANTEFDDETVATSKEWRPVRYSSAWTFIMVLGLYADGDTKLSVETILQRSKELIERMPKCRLTNLDFVRTLVEKSIVDFVYPAKQDEGNVEFNSKKRRFYLYGLTQWGQTLAEEIISGCEVPISNRRLQADVFSQTQRSQQVPPGVYAAIPRSQAGTGDVVDISDDQEHTASASDYYSEYLSDSDEEMEDILVASGNSLNPPGNGSPTSSQCQKDTDVKLTQISIDEQAIEQVDPNVLLSFKCNDPSQYVGDGTVGKLKIKGAYTSISNYRYTSNSNHPSATGKMVPKVETRPLPITEVCVISDSTQSLDSVPKTAGSNKDATSPLQSQASSRLGAASQVMGSQAGAEQVSAMAVGSQAGEATLQDINCETPKVSDANTAHIVVKTPVAAKDRSVAPKMECGSEGFRTPDPSSSADEAAPNQQTNDDAIGKTGEYLSPQNGEDESVYSDSPYSDDSLDITDVTSDRYRRLMDDYHGASQCYSQSSDHNGAPMLELGSQMVGAERDTAANDLGAVDHEATQPTRQHTIQSSQLEDTESYPNHPSRSSQLVDTPLAARLTQSQVKRTGLEAQEQEPIEIDSSSSSPIDSPIPAPKSATRSELLQLTIRSVAMSPQKDPPSHLCRRLQSRQGIAVPDGPEGYEVVTVVDNREVNDADGRYKRRIVDLFSAAGKPVVFRQLPLGDVIWVLRRKNQGAEGDAPAVTAENDLVDLIMSQEEDPDEKRANAATRSGARNPNATAAPKTANRGAKRRKASGANDQLADSFVLDWVLERKTTVDLAASICDGRYDDQKIRLLRLIGFKHVCYVFEDIDARAVVGRTKMHKGVNAAAITSARVRTQMVTGFNVLRTTGMPHTAASILAMHRHIESRTHEYMREANTTSGEFLQLWIQSRYMPLAQWKVRNRKRNQLTFRDLFGKQLRAIPGCSEATTEAMLAAWPTPYAFAHALSNSNLAHINETLGKHRRRGKRAPVNSSSALLQDEATSAARSAEVTAHAGQLALVAAMWSWQVQAGHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D649</accession>
    <name>A0A061D649_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767678.1">
        <property type="nucleotide sequence ID" value="XM_012912224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D649"/>
    <dbReference type="GeneID" id="24564033"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206500"/>
    <dbReference type="OMA" id="ACVISSW"/>
    <dbReference type="OrthoDB" id="367248at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595821" evidence="1">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="153" mass="17107" checksum="0B2226DA848DB880" modified="2014-09-03" version="1">MWYIKFVATLIGAFLTVSAATGASDPGGIHLNIEYPKDEQKGKLDVATGDGVGSSDIRTPVVIIAPKPLVDYERLYKKMMHSAPSEKGRANIEKDLLYNKKVAYSDPSSRRQLLFELLKEAEADLAFYRADYSEMELFYLITYAACVISSWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D684</accession>
    <name>A0A061D684_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767713.1">
        <property type="nucleotide sequence ID" value="XM_012912259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D684"/>
    <dbReference type="GeneID" id="24564068"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206850"/>
    <dbReference type="OMA" id="FGFMERH"/>
    <dbReference type="OrthoDB" id="364744at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="54465" checksum="2ED396A157439A2B" modified="2014-09-03" version="1">MDREQRVNGARLVGEHAHGLDDVDRGPAYNFDLQFRGGLTAPGAPPESSARGAKNKLIAGQCSYATWVERLRVLREMREDVLHEPALQHMMNGLDACIGALASVVGTPVTREPPRIPNSYDIPAQSGSVTDRAVNYPSVTTDPMESIYKPAPLSARCTPVAAPFEEQALPGHQSYTMDDLIGSLDNIEVSTADDEIPPALRLEANAAAAYFDDAMVSKLYSRRWMRRFEAVGDIVALVDSDEILATNDDSIQRAVGGIYCALARLFRDHALKVLIKSLELLDSFFGFMERHGCSVASSARCATERGDAPRSKTERGAAVSGGAEFLEALIARLGDPVSAVVNCAVCALLKVAESNTIPTYEDIVNCLIRSLGGYNSQPGARSICNRLRLVSTLLLRAHLYNSHGVARLAVKQAPFFETVGALCRHSHGSVRAVAVEVLAIGTKIYFSGATPNLDPVICDAAERIQPQSASVYEGTAEERTRVMIAEAQASWPADLLRARTARQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D692</accession>
    <name>A0A061D692_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768397.1">
        <property type="nucleotide sequence ID" value="XM_012912943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D692"/>
    <dbReference type="GeneID" id="24564752"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301160"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="149" mass="16689" checksum="559D505C05BF929C" modified="2014-09-03" version="1">MEVSALEEVKLITKEFLEKPELRNRRAVRAILRRFNKPMRKVGFCHRLFGRIVDSDYENVIETKGLTAENIAENIGEIVDGCKTFLHHIKNPDYYESAYNSEATSDASCSEKPEDFAAVFVGIAPMLYAGLIAPLVASRAGFCNVAVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6M6</accession>
    <name>A0A061D6M6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766785.1">
        <property type="nucleotide sequence ID" value="XM_012911331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6M6"/>
    <dbReference type="GeneID" id="24563140"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108970"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="164" mass="17177" checksum="6271558A7AAC1EE0" modified="2014-09-03" version="1">MRGWLRELGTAVAEGTGSGEGRWEGTCGRVYVILDVEGNEYKCKCKCCLQKCSSKEKPGICIPPPPAPPPPLSSTGSESSSASSSVIPAPGVAGARSGGPGPDGEDMSTTSPTFSPSPETIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6S1</accession>
    <name>A0A061D6S1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768577.1">
        <property type="nucleotide sequence ID" value="XM_012913123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6S1"/>
    <dbReference type="GeneID" id="24564932"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302950"/>
    <dbReference type="OMA" id="CMSARIL"/>
    <dbReference type="OrthoDB" id="361705at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595505" evidence="2">
        <location>
            <begin position="21"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="643" mass="72414" checksum="862560239C1437C4" modified="2014-09-03" version="1">MKPATYLLLLLAAPLLLIRCHDDVADLAKAVASDLEDGEVDELDEALYEGFVQGVALNFDYVSFGKQSNNHTELTPQEKETEHQHNLHKAEIEADYLTKHRPLESSVVDETESDLYSLFNILMHYLSSRSQPWKLVEPKSQGLEDGMEHHMIFISEAVNSENKHIPRNMVLSVGDIAKSKLHANGVYRVAALPQKGGKSPILLTCLETFIVSKLAFNLMSRLVKSPAPIDTKLKYVDRWIHLVQNHFVLYLPYITITAQRCVNMLSEDGQLKSEFSGQHYETLLKNCKVMVDKRDDESDLQTFVMLDAELHSALIERCIHQRHIIPSLLEEKETHLKRIHNVLDREMSWETFSNAVNMVFGDVERNILKADDYLMKPSTWGCGLSKSEANEAEKKLIGAFIKSHVELNLKVRSTIVKLNRVIADAAPDKGASLAEALLAFVEHEHHAATEEAQRNNELSQCIDDAKRKFSEEADHYGENVTKESYKSGIAVDMKKYQNEGWMPCMSARILNTIVDTCSKKTQYCKVLLEVLRDFIGELEPDSTSALVMENLHNVVSVSLLKNKDITAEDLRSYLAKVAKNELKEVNSLSGGSDQAKPSESEPKETKTEEAASGGSEHDKQAPTEESKQHEVHSESSEQAIKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D711</accession>
    <name>A0A061D711_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768479.1">
        <property type="nucleotide sequence ID" value="XM_012913025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D711"/>
    <dbReference type="STRING" id="5866.A0A061D711"/>
    <dbReference type="GeneID" id="24564834"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301970"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="790" mass="86771" checksum="40FB6FB468858DD7" modified="2014-09-03" version="1">MLAALLAHLERSNPRECAILADLESLESRLDELLLSQSHSASLKTIGVCPRLRLHISNTYEEQDDYPNRQGFVHTTPSSFTIYIRAYEVDSDGNLADGEEGVLSRYFRQILLCTPDRTVLWDRDGVRDLSPNSRRRCVAYPPVDAAASDAAFPEFGHRRDTLGGLIRDRVSSLYGGERRGRPVGNGAEKGRDSPTACVGMYGANDGRCLNGDPLYNNPGDYGEVDGEYYEPGFDFWRHSDSKQRDVGVEERGVDPGPYNGYDELQISQVCYSECQVTLYFFPTQLTMMCTISDLLESFLLMVNDGVAVTDSSRQIAFYRIISFLWIYAFERHLVYEIEEGTFFRLDGTLSQLLEMPQGSELTVQDVQQAVMVHVMPPKPIKVTHDIVLSGDSWKSASFVDVHLDSAIRGRKSFGKTEFEKQVDSLLPELRDLIHVRNIYDSYSRDPAKFVKFALSSSNVTIDKPFSDDLVRSSEKICESWLPRAIDKYMTLRDRSLCDILLGAFNSAPKSTTARDEVSDLSAREMFVNELSIEPVDQDGVPISAASDAISVVGEEDANARPSKSESISTEAKFDTSNDAGEPVTHDAVPAENGETANAATAVSAAYAQVEDNRMDSVSPTDIYNVNGVPPLGANDGIAAAYTACLPAPGTVQIVPKVPGEGDFQVPSFESAPHVSPYLGGGHDFSRPGKNVVVPSSSLVNPLGNYVSPDGVETTCVRVDLPGPGVTQQPNRLCIDRKLKETVDCMVPGNMIHHPSYSVETRYVANSVVGEGSRSMEGDFEMYGANGNEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D754</accession>
    <name>A0A061D754_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768544.1">
        <property type="nucleotide sequence ID" value="XM_012913090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D754"/>
    <dbReference type="GeneID" id="24564899"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302620"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="302" mass="33424" checksum="72DCDF311BCBD4E0" modified="2014-09-03" version="1">MVYTSLTEAPHNLKEGIDWLMALKGSCGESTLKAMAGAIHHLFSKHSDGYKQLPALEKMKSISREFLEKPELRDNLFVKQLLSRFYTPASTANTGFKHLLARYSEEYARVVGVKGARPEYIEESLRNVMDGFGKLLNDIKNPDKYKSAYSAEATWEASCAKDPEACAVVLVGMAPMLYAGMQSLSNAVFSKSGWWSTTVEYKAAGDVLRPLGYEESECRAGMNGSYIYETFKGLDADLFHKTYDLAGFDIFYGSDIVQKLPVKQPVVEEALVAETAVDPVQAAKSAKTRKPGQSGRRRKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D785</accession>
    <name>A0A061D785_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0110660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766955.1">
        <property type="nucleotide sequence ID" value="XM_012911501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D785"/>
    <dbReference type="STRING" id="5866.A0A061D785"/>
    <dbReference type="GeneID" id="24563310"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110660"/>
    <dbReference type="OMA" id="VWFSHNG"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="352" mass="39358" checksum="98E6C652A2D19E96" modified="2014-09-03" version="1">MRPLVLRGHRRPLTCVKTNREGDLLFTCGKDASLLLWRTDNGQQIGQYNTGRGAIWACDVTVDSKMLIAATGDARILILDTFTGEMIADIKDEGACKYVEWNRNPQKQDKFVMIHDDFGESVFMALKVYKLDFEQTEEGGLAVEHRILWTQRGYRSRAIQCHWGALDKDVITCHENGTIQVTHALHAGKGAQVWDAENGTNLHVIEAHTQTVTCISFDLYGLFMLSCSSDGTAKLWETLNWTTVKNYKTDRPLNACVISPCFKMDRVEKAHILLGGGQSADEVTTTAASEGKFQALLHHLIHEVEIGSIKGHFGPINTLTFLAEGNGYVSGGEDGNVRIYHFDKDYILDKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K7</accession>
    <name>A0A061D7K7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768714.1">
        <property type="nucleotide sequence ID" value="XM_012913260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7K7"/>
    <dbReference type="GeneID" id="24565069"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304320"/>
    <dbReference type="OMA" id="IHLHMYI"/>
    <dbReference type="OrthoDB" id="411646at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41358" checksum="B9E0943E08237D79" modified="2014-09-03" version="1">MHQKCDEISANALMCVLQKSHGDLYRALFDQHAHQKLLLLPVAQALVNVHISRKFVECHILRETEVPGYFLNLDGQAVEVNAAKVTTSFGFKNHVAANIVRDDKIHDLQNAVRVCLIDDYLLHAEHTCKDMFEIDLNDVEATVTRWCEDSAEFHKALYGALDRVKSTFVMVPGYENELCSMLCTQVENAVNAYIANKNDELKCSKHNMCELTLNFAFHYLNEHIMEHFRNTYSKQEDIVQNRIIKLRKEMNPNSTLSLLDGKRQATNHNLNPSCEALKMMAKTKLPQDKLKHLARAIQFNKPESRDEAASLFILTLVAGGLTDAVANYALVDMYASAKFCKHKVQTQHLDTFREGLQFLLEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7L0</accession>
    <name>A0A061D7L0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765896.1">
        <property type="nucleotide sequence ID" value="XM_012910442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7L0"/>
    <dbReference type="STRING" id="5866.A0A061D7L0"/>
    <dbReference type="GeneID" id="24562251"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100390"/>
    <dbReference type="OMA" id="MFHNFVG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="441" mass="48882" checksum="11AA3A798B98D9A8" modified="2014-09-03" version="1">MTTKPFIVDFGTVTVRVGRVGEKIPPFIAPPYFGQPNLKVDQAELCDFSGGNVNNWLDYAIFPLNPREKHDNTLPIPAVTYEQGRYKLKYSVMDKLLECAAGSKFVDDIMEGGAVIATEPNIHSPEFRKTMAEILIEGQRVDKFYMCKRAALSCYATGKGSAVVVDVGGACSNVTVVSDGYVLQETIQEQPMGGTLLDRILLGHLNRSGTKIRPSFEYIKASKSDDNAATKYQKKNNEARAVSVRQLPFVREEYYDYARLYATSRVKETCCIMGEKLEVDVEASDSCFALPDGSYIDTEMGKAMCGVFCCCIFSEPEYLQDVEDFNAFQLETLPKLPKDPEQLTLGQTLRNLRGLDVLLANSYSTAAEMEPAACLPEALRAVIMSDVEQPLYMAVGGDEQQYSSFIGASILGSLGLFESLCVSREECQEHGFERILQRKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N3</accession>
    <name>A0A061D7N3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767090.1">
        <property type="nucleotide sequence ID" value="XM_012911636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7N3"/>
    <dbReference type="GeneID" id="24563445"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200610"/>
    <dbReference type="OMA" id="VSYATHQ"/>
    <dbReference type="OrthoDB" id="361676at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33962" checksum="5B26199A47A7CBDE" modified="2014-09-03" version="1">MTLKAIQKKRAANILRSYAEGIHAELVKLRGEPGDHADQELKLTTQLEANLARVAMLHKQAELMQHQAAQAKEELSNIRSSTDRSRVVGVGRCRYAMWPTALNTECNMLKIGPLFYSARSDDVEHKDKVPLMAKLNGNALVLYHEKEPQLTFYLVDVELPTRPVESAPSCFSFTYRGAEQALCAGSEMSCHTWMNALTEAWFCKNQGIRGVMTNTRHEKKEEPSKKDGKKKKDKEKADDNTIMKHAVKEDPNKALVNMEVYVDDKNKTHMIVNGKERPVTAVADLINIKEIMQQVKDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Q9</accession>
    <name>A0A061D7Q9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768764.1">
        <property type="nucleotide sequence ID" value="XM_012913310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Q9"/>
    <dbReference type="STRING" id="5866.A0A061D7Q9"/>
    <dbReference type="GeneID" id="24565119"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304810"/>
    <dbReference type="OrthoDB" id="367189at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="392" mass="43630" checksum="60D07AF00B844EC0" modified="2014-09-03" version="1">MTYVQPLDVISPPTSAIDLNIEPFDAAPHSIPEDFDENTIKRPDIGLCISSWATSTPTNGSTDIPETELFPATAPRTVRDMLQWLAGLKNEKHHGTLEKCINRAYSGQRSAPSQLALSINHTNIRPKDVFDILQLTVMFATSVLTAIAPNWKANVPSRTVKPKSSEEPDCCALLCQLRDYAYACHYQLEFLKAQCNRDKLHGGWQHCHYGSDITASKSPLQAFLTDGWDCPFKTHLFDPCNLCLKSRIRMGFKKEDLPKESQLGSTLSTILTPSCGGEEYDALLGTKCMICTIMVPSKNYEAAITASQYHWLYNRLYVTTCGTNVSAIGSHHIDIRGYLATVGLCGIGDAIILLEFRLGITESITYLAEYFAKAYVINFTHDVKDQDKEGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7W8</accession>
    <name>A0A061D7W8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Nuf2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0101190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765976.1">
        <property type="nucleotide sequence ID" value="XM_012910522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7W8"/>
    <dbReference type="STRING" id="5866.A0A061D7W8"/>
    <dbReference type="GeneID" id="24562331"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101190"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="332"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR93790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="463" mass="53745" checksum="A3673341DBFD865A" modified="2014-09-03" version="1">MDLTDETRVIDELFRKVRFDEILEDLKVLGVDVREQTLKNPTTEEALGLYGLAIQVIFGKTRTDIRPEDVYSQIHVYSSGVEGLEITSDNLDFLKRGVGNLRFWRYCQKLHETLGLPDIERYELFNPTPESFHRFISAFVVYLRFREALKSLFEDAIARLNFCAEQEEQLEDNIGKVQQELQNFKRLKDENADDIVRSAGDREHLEGLLLQAKSVFNEHKEEKAKLDADINRVKQTINDVQLKKTKARHRNEMLCEQIVSEPDSLHAQKDELEAQEVVQNATLKNLTEEFDEAKRRFRLLEDCSHYVEGVKAKMARHLDEVLKPLAENLSASRTLKARNETLQQQISRQKEQRDSARAELTAKQQLNEEKRRLLQEAADNELKAARKFSEDTHNEVVEMQQAISQEKKKVESLKHDLAEREERVTAVFSAAQASWKKVTDAADSYAQRMDEIMDNVEKVIQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D819</accession>
    <name>A0A061D819_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor Tu GTP binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0307050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768987.1">
        <property type="nucleotide sequence ID" value="XM_012913533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D819"/>
    <dbReference type="STRING" id="5866.A0A061D819"/>
    <dbReference type="GeneID" id="24565342"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307050"/>
    <dbReference type="OMA" id="CHIFDLW"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="128"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="647" mass="67677" checksum="191C75527A06ED72" modified="2014-09-03" version="1">MAAARRYAGADSEYSCSDSDYDVSDYDDFVVPVHKKGQGRRGGAPAANVQPKSRSAAAAPKPHVAQKGAAGRSQEPAAKGVAGQPGARTTSSVVAGAKPVQSQAKPGSGNAPVRSNKGASAQGERGSFPVLNVVVCGRVDVGKSTLLGHLLTLLGAVESRSLRGEFAWILDQGEDERSRGITIDPTKASAVVDVVPPPEADGSGSRDGTVRQSAPAPGTDAVAPVPAPSTNRRVKLNFIDTPGHHELVSSLVRGAIFAEAAVVIVDVLDFLKEDTNGYFEQHFFLLWSLGVRHFVICVNKVDRCAERESVEKAMRMARERVSSYALSTLLVVPTSGMSGLNLVHRDSGWGDGPSVVDALRGIAQKTAFSDESACISPERQIPSGATLCHIFDMWEMSKTNVGCACFLETALNTPCKLVALPSRSAVTCSEVSCLVPASEGALSTAKSGSNADELTARLGLMSLSATPSASRRDFADSMTLRGQEIQALTGDRLLVDTATLEHLKAGSGNLAEMPILVCHVLVHRGSSHKLTLGFGVTAFVGYFQSNGGISGVWERVGAGKWKRVTSLWPGKEGVLVLQLSAPLFAQPVPLSAAEALVPRKAPQASGGEPRGPPSQHNAPRLSLLSRVLLKAGGDVVAGGTIVDNPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D821</accession>
    <name>A0A061D821_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Formate-nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0300520</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetate(out) + H(+)(out) = acetate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71803"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>formate(in) + H(+)(in) = formate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:80887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>pyruvate(out) + H(+)(out) = pyruvate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64720"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768333.1">
        <property type="nucleotide sequence ID" value="XM_012912879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D821"/>
    <dbReference type="STRING" id="5866.A0A061D821"/>
    <dbReference type="GeneID" id="24564688"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300520"/>
    <dbReference type="OMA" id="MIWFPIM"/>
    <dbReference type="OrthoDB" id="4829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR96147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="278" mass="29880" checksum="A515484E937092F9" modified="2014-09-03" version="1">MEYVCQLRKPADTLEVALASGEAKVKCPLYILFLKAVMGGYFAALGGHAAMVLASHFYLEHHYAASKLAFGLIFSGALVCIVFTGTDLVTSNCMNFALLAYTMRIGPGDYAIRMATSLIGNYTGAITGAAMLSAGTGFFMENVGSGSPYLKAVYDFKLSLPFWRVIFSAIGCNCYVCMAVWCSYASLDSSGAILSMVLLIASFAVAGFEHIVANFYTLHAALMSCKETSFLTVYGSNLAPTLIGNYIAGSVIIALPIFLMYGRKHDENVTQTYEDTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D834</accession>
    <name>A0A061D834_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0102090</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766066.1">
        <property type="nucleotide sequence ID" value="XM_012910612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D834"/>
    <dbReference type="STRING" id="5866.A0A061D834"/>
    <dbReference type="GeneID" id="24562421"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102090"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="60"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="241"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR93880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="402" mass="45601" checksum="E2680244A1A95420" modified="2014-09-03" version="1">MAPSDNFENQPAQSNAVDAMESNYDEVVDSFEALKLNEDLLRGIYSYGFERPSAIQQRGIKPIIENHDTIGQAQSGTGKTATFSIAALQLIDYSLLSCQILILAPTRELAQQIQKVVLALGDYLKVQCHACVGGTIVRDDVMKLKAGVHMVVGTPGRVYDMIDKKALLTHKIKLFILDEADEMLSRGFKGQIHEVFRRMPPDVQVALFSATMPNEILELTTKFMRSPKRILVKKDELTLEGIKQFYVMIDKEEFKFDTLCDLYESVTITQAIIYCNTRRKVDMLTSKMQERDFTVSSMHGDMGQNERDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPMSPDNYIHRIGRSGRFGRKGVAINFLTPMDMEAMKNIENYYNTQIEEMPAEIGEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D835</accession>
    <name>A0A061D835_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn finger domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0300620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768343.1">
        <property type="nucleotide sequence ID" value="XM_012912889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D835"/>
    <dbReference type="STRING" id="5866.A0A061D835"/>
    <dbReference type="GeneID" id="24564698"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300620"/>
    <dbReference type="OMA" id="HCGNANW"/>
    <dbReference type="OrthoDB" id="430695at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999:SF17">
        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999">
        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="88" mass="9892" checksum="499077EDF576E504" modified="2014-09-03" version="1">MGKGHGDWVCPVLTCSNLNFSKRDSCNRCGFNRSQGGGADAPLFRHRKYNDWLCEHCGNANWSRRRQCNICRQDRPGCNSDGPVQCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D843</accession>
    <name>A0A061D843_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766076.1">
        <property type="nucleotide sequence ID" value="XM_012910622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D843"/>
    <dbReference type="GeneID" id="24562431"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102190"/>
    <dbReference type="OMA" id="VKHISQY"/>
    <dbReference type="OrthoDB" id="365976at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="639" mass="70542" checksum="A1BF305CB5D1E33A" modified="2014-09-03" version="1">MTPENYGHSGRKEVTVGCFQAKSKQHADGLTKVMASSLEALKLAPSPAPRSVLAAFERPSATLPEHCYYCGAQGVTNLVPQISFNLQRRTATLVARRVGSMYTVVNAHQGACARCKQILCLSDINDHIIRTAMSRSKAVDEVYEHFLDVNDIRKWSSLKLQGVVLMRRRAARAAVQLTGSRPELSYGRFMGTEFYMSALKPKIVSKSGVVHCGLYSMKPCSPCAGEGIAHPPQTDIGKEPFNNSNSPPVSYKRAIDAAIHLAPALKGKRIPYRAREYLQRCLLEEAQGINISNILPLINATLDMRIMSESMRQVFLEKMEEMHRAPAGTTEERLRLSEAALLMLSLPGIQDLMATKYVELCLSILKSHTQHAPGDVRLRTGLLYASMLPSGLISLEDIRSIILTFTGNRDIPSHPMALNDCSAVVALLNVTRVYLAVRGKGWDSDPHGNEIKSYVTQVMIPQVVSNIYVFTAAHLTDVLSFFADTGLEAWATPEHADAPISLTHLLGGCCKRFVRDVSQFSISDMLSFHLALLRLNHRDEWAILALILVLPRRAQSLDSVEQLVRLLEFAHLAGIESQFLVEFASEQLMQLAHKIGRRHCQMLADLLSRRPVGGPVLLDSSALQALDSVGAKYGFNLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D874</accession>
    <name>A0A061D874_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768373.1">
        <property type="nucleotide sequence ID" value="XM_012912919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D874"/>
    <dbReference type="GeneID" id="24564728"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300920"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="17281" checksum="AC3AF0BABD8B095B" modified="2014-09-03" version="1">MNLTGSASAFTHQLNVYNLVFSTVVFAIYTCCGKFHVFYGPSKLFYVAALVQCAFSIWLLGFPASYVAIYTVCIWSMIVRGLQATMASVEIFHRNKQHTNRILCGMNDDEDEIILNVTRLYTLPFPSAPCSLDNGMFLRRFRNLETAELRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D886</accession>
    <name>A0A061D886_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769082.1">
        <property type="nucleotide sequence ID" value="XM_012913628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D886"/>
    <dbReference type="STRING" id="5866.A0A061D886"/>
    <dbReference type="GeneID" id="24565437"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308000"/>
    <dbReference type="OMA" id="QTTHNIF"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="794" mass="89262" checksum="D3679CAC4389B3E4" modified="2014-09-03" version="1">MAHQLSLVSIYDSTTSSVNAVAFSPCGQYIAAARQPFAVEIYNVETRVHITSLRESDEHAAIRTIIWIPKTDGLVGKTLSGYRIITIGLHAVITDWDLELLLPVRSCCSYGGAIFSAALTQCGTRVLIACDDGRVRAFRLWSSDDRHTRDPELEFDKVYACHTKSILSVCALPDGSFFCGTADAIIFRHGPSSEAPATKIKVPGLKKQGPPVSKKRKTGNADSEAEAEAETDAAAEENRLANTADDQQEPQIWALVFIEKHQMLASGDSAGNVILWDVKTCTMHKMFTQHCADVLCLAVGADGDTLFSGGVDTQITVYAYNERNYLKQNAPAGWSANGVKYYHKGDVRCFAVHPNDDRIVSSGSDGILTISRGLKHQNNKRCRTNLILLNIPSWVGSPVVMSKDKTLALCRYRDHCDLWYVPRESPDDTEMPYKLAAIKLKREGGQIVAAQLSPDASVMAIANQKHMRLLRFCAENLEIRSSDQQVQEMIVHAMHFVSNTELLLSHLEKGDTKFRLSRFNVETGEMRQLQHHISDPIIKIDVARFNLDEKLQRRLITLYSLEGFVYLLDLETETIHELPRFENGYRVVSTCASPDFKYLAVFSKGSLYYFYNVEMRTIIAYDGETIHRVPNRICNSNVQIYNAIWYNKDQLNRIFIQTSNNLYAIKIEEELFGVEGKSNREKPATENARINTRQKIYIGPRKFSDAPCIKKYLHQPPALFRASLQHLKQLKSAEPEDDAEVAQQPLAIGRYLGINKSKFLVHMELTAAEGGLKIIAFYMAPPHNSIFHRKRYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G9</accession>
    <name>A0A061D8G9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768979.1">
        <property type="nucleotide sequence ID" value="XM_012913525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8G9"/>
    <dbReference type="GeneID" id="24565334"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306970"/>
    <dbReference type="OrthoDB" id="10421066at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595555" evidence="2">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="34285" checksum="910A1D136DB1E811" modified="2014-09-03" version="1">MGGTRLSSYLPVLLCCLLVAVTIGLPGNAAREVGQSTGGARVSLQLAKKKPVKPGKGEVEAEIQPDDSASVRKGTVKKKQTVHIKRSDHEALYKNIKAKVDSFNASHGLANSFEPITLRDRLHWLACFAEQLAAARRFLTSLENLMEYNKGKTPATLLKLFKDYSATVYNLSRTLLIRTPSVKDCPVKITENNLIPTFRRVQDMRHELLADAADMREMAGWLAINFKDVDIVVPGSEFFRNWLTTAGYREELFKSNINFALVAKAFEELAGREGEEDSGYISQIFSYIEPIVETPAPPVEKQRSKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H5</accession>
    <name>A0A061D8H5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769197.1">
        <property type="nucleotide sequence ID" value="XM_012913743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H5"/>
    <dbReference type="GeneID" id="24565552"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309140"/>
    <dbReference type="OMA" id="DIVMSHE"/>
    <dbReference type="OrthoDB" id="360496at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="797" mass="88476" checksum="0C14EA64519953FC" modified="2014-09-03" version="1">MDWHMLTASASALAPLDAGIQHTSVVNIFKLSKEWANAAGADEAFAPESAGQPSGRHDKEKTGYVVDLDDGIVDEEGTQWCDKDLQLWERDKAAVVESLMNRLRSSGSSARIRDKHDRNGETPAQSKAEPAREAPDIVMSHELEMLLSWLDRHAHNTASISEEARRIFVDNMIPLLRKCDANAHNFISFMLDIARLGDGKKPDFMKSYLRVALKHLQKHAWGSLHLAILNTKGIFMDALIAAPHQKPQEILKMCVECAQLIFPSQTAHISSGAKPQNSEYYFFIAYLLFRAGSEEGLRILIGKNGRYELPPGMESERYPPMYTDICQLLIGVMQDKEPDANKQVLLGKFTAEYFPTKQANSITLLGKGSNFYALLLLSIIYPDYYLPCDADSLHTKEDYLWYQIHIILAGSSTSLSMSAATLCHNLTQEVNTIKATDANVVERVFTYAYSLALVGGVMEALRLLMSAVHDPNVQAVALVFLVYFENTGLLGADDLRYIASALWNMEEGTGKLEEVPYLTQLAFSRKRNVSPELKILIATILPQQKATACMKYVVSENFNDAVNTCFIGTATTRNGMLVIGPLLQKLIKLATRRSAAKLAIQLMAQYSAHVGLWAAAFKCFYCTQDVENCVSVLEACCCYLYDNAEQSGATAVTGDDLCVYFSLVKSLAPGNKRLAELSSLFDCINVSVLVKKGDYAGAVMDARRNHIFDSVAHVLRNESHQIYFNALVDYIRALKHMVENGHQPGTLLTQPEAHNLVDLLESAYQNCNADKNRTVDAIHMLMTFITIVPPKPGQDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I1</accession>
    <name>A0A061D8I1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent RNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0103690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766241.1">
        <property type="nucleotide sequence ID" value="XM_012910787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I1"/>
    <dbReference type="STRING" id="5866.A0A061D8I1"/>
    <dbReference type="GeneID" id="24562596"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103690"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="82"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="262"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="424" mass="47539" checksum="8AF43B5E22F12519" modified="2014-09-03" version="1">MAPVISPGDLPPAKLSAVGRCTVDSAWKKEVLEKNADKRYKTEDVTKTKGSQFEDYFLRRELLMGIFEKGFEAPSPIQEESIPVALAGHDILARAKNGTGKTAAFVIPLLEKLNTAQNHIQGLILLPTRELALQTSAVVKELGKYLNVQCMVSTGGTSLRNDIVRLYKPVHVLCGTPGRILDLTNKNIADLSKCHVIILDEADKMLSAEFQPIIETLLKFLPTEKQLILYSATFPQSVQKFKEAYLPNAHEINLMDELTLKGITQFYAYVEERQKVHCLSTLFSRLQINQAIIFCNSVNRVELLAKKITELGFSCFYIHSKMMQADRNRVFHDFRNGACRCLVSSDLFTRGIDFRFVNVVINFDFPKTSATYLHRIGRSGRFGHLGLAINLVTAADKDALFRIEEELGTEIKATPAHIDPALYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K1</accession>
    <name>A0A061D8K1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0307420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769024.1">
        <property type="nucleotide sequence ID" value="XM_012913570.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8K1"/>
    <dbReference type="GeneID" id="24565379"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307420"/>
    <dbReference type="OMA" id="RRCEYER"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="1126"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="919"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="942"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1639" mass="180903" checksum="C160FD1CBEE6BF26" modified="2014-09-03" version="1">MASDGAAQETDSCPDQTPVPESFMGTLSAPPTDYISALAQYGSISGASEWSRGDKYASVSNERLFYDSGSFAHPSYEGALYQGFEPSAWLVESEVLNRTRRCCLTGEPVSLAADERCDACLGLLIGDACRCDACGVVVHPNCYGPESRSWEWYLGSSQNAFPQTQGDLFSYDQATFTTLHSPFESPRRRRSASCDADGPCESDESTAHLSDRPTAYRDFTCDVCAAADGAGTPQCALCGLPGGAMRHSPDCDRWVHCSCVAFAPESSGIAFRRMLRMRDPVGIQAFIAQMTPGGNACDACGKSDGLVAPCSFAKCSKFVHSRCTTFQEGYRGCAFSDQVYYRLDMGEQYFDFVGAFCAQHSSYDHVVMGIQMQLRRRQVLREQGSSSYRKYQGEVADIIRMASAVTASALHDDGEDEASEALSPELVLRMKSFIGGPCEGGDGDDDDDYDDDEDEDDEEEEEEEEKWEDDDYGIGEENWDDGYEDYDEEYEENWEEEYENGDDEEEDKGQEEEEYEENEDRKGGSEMDECDSELQCEEWSFDEWRDYLLSPAADDADTYEVAAIQDVDCDEIDVNMPVDVASPCDDVPVVDVQAASGDGGLDSSGSQFRSQRMMWQKFDIFRPLPYGPASDDLLANMDQNARKKSVAEYWRLEDNVLTCSDFLEPRDLSEMFLQQVMLGCNGVMDLLQSLKDDVDQELQSSAKANNGMPADERRYSRFHVLVDTGRTAGVLIFKVNKWLLEVLQADAALTERTDKSAISAAGIALDEEVRHFLSHVQGEVARNTYSNTSFYTNSGALKEIDFSSGIGEYGLRDDIRQLHQTVNAVTSESELSRIRRKMLKKGKGDPSLNSMELEKFVVLSPMESELLRRCAFEMSHANDANVKLAVLKNTVDASVNTSCLQMIDWAAVMAKIKTSTHFTASIKGSSKGSSRPSHSAKASRNSNADKAANSEAAATAPEPSTSGSSGRTSAAAAAAAAAAAATPNNDSGVTLPPVPMVHLGKHTWPVVDDTNFVRRQKEITECDLSIVSSQLRKIRENIRENVLEMNSGPPTMNQRLGYASKLLEQYESVERWTTLVTNFCRGLSDSQDSLTPTVAAAPRMQSPVVVTPNTPDIRNAAKKAEGIAEGAYCSVCFVNKGNNLNPIYTCSRCFMSTHRNCYGVNRTGKESDNSDYICRRCEYERRTMGGQWQTAFRSCSILCSICGRGGGALKHCDLEEWAHVFCLLCLMPETECSNYTTMEPWTLAGIARWRREAICSVCGVGWGYVMRCSDCEVAAHPLCAWLHGYRVQAVSTVGYLSHEPQDSGLMRELHVRVQCNAHDKSRQWQQFVTIRNKRFLNRDTAYWLFEGCDKRRKSRAVFLESLMSSESMDPGSMVADPAYLAQLSGDRRCGVCFGTGMLTECGHCNARMHYNCYVELDAKGASSILSDKLNANKHVTCDVCSNGDEGAICAICRVSTGLLKQIPTARGGADAHRRYIHAICGVCFPEVLLRVYTGEHDVDGTTPQNVDSAAASANGAAQCACCRSSEGLMVRCFREGCSVVFHAICGMINRYVVESHNMDIAAGPRYVAFCQQHSLLSRSVGNNVKLMLRLRPALKLLKEAVDDLASQDVVMRAWYRKRQELLNAECPLGTLIQKPANKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8N8</accession>
    <name>A0A061D8N8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766301.1">
        <property type="nucleotide sequence ID" value="XM_012910847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8N8"/>
    <dbReference type="STRING" id="5866.A0A061D8N8"/>
    <dbReference type="GeneID" id="24562656"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104240"/>
    <dbReference type="OMA" id="FLLFREC"/>
    <dbReference type="OrthoDB" id="408698at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16492" checksum="BDE198C270C17A13" modified="2014-09-03" version="1">MADERACAPHLSDFYGCLGRSGRDLSQCARELGALRQCSDGDKNENYCVGELTRLIRCTGEPDRTGCAKEFIAFRECHRPGGAEILIKDNMYKISKDHMHKYNVTSDVICPASAPKRDGKAIRAALDKLRAACGFKNYEENFTPKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8P5</accession>
    <name>A0A061D8P5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766306.1">
        <property type="nucleotide sequence ID" value="XM_012910852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8P5"/>
    <dbReference type="STRING" id="5866.A0A061D8P5"/>
    <dbReference type="GeneID" id="24562661"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104290"/>
    <dbReference type="OMA" id="HDLFFHK"/>
    <dbReference type="OrthoDB" id="348318at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="374" mass="42309" checksum="2F948948DC4CBCD6" modified="2014-09-03" version="1">MAFDSFDSPSRREFSSHCQRMLSLSEDYKEVGDSDCGASDSSYLNSHCYRSRRISASYASDSASVKLPDTSDASTPRSLSGSVYGRDAAKAFKTKSVRDLECEESLRRLHSLVAGDSVYFCRAVLGTSEDSDDSDIGEFVEGKVTCFSYDFMRRYVIVSLDGYGSLKFTYGDLHAMALDGNVHLQRLQQSVVLSKAQRQKRPRYFEDEYMTRRSFSNQNTADDSEDAAHDSAYGSSHHAYSESSAAGGADFYGIRTRPVPPGAESICRCRFVNKVDLVQKLRSAINKNKQEFYERTETMQELRLITTQNVRAYELEMVAYLLGEDPWAYAANHYDRPTDEQIKEIVEQYGAAARNAKYLAHFANWQKFQKQVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Y1</accession>
    <name>A0A061D8Y1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768613.1">
        <property type="nucleotide sequence ID" value="XM_012913159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Y1"/>
    <dbReference type="GeneID" id="24564968"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303310"/>
    <dbReference type="OMA" id="DNLFSCY"/>
    <dbReference type="OrthoDB" id="365161at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="657" mass="73360" checksum="8519B9B05820D852" modified="2014-09-03" version="1">MSVDNGVVDAPKLESGAVVHCGLSEQSSARGAHTERETSALSFVDIFRDEVGVEGRSVQGSHISGAPIADNVDRTRGDVMALGREPRKLTFSDRVLYEAKKLRERMQRTRSEDPGHVTAENHYANTSAVTQPAGAADDFSPYTTWSSARNRLPFDCETGGLGRSRLRAAEAYSELVLRSNAQVMEWFRNRFNSIDAAYSKRAIALVDLERSVIPIRLVQEPVEAVNRDTEELELLRQENERLKSLVESTTQLKQRLEEAKLNVEELENSLAIERKHNEENIRDKMTLQQRIAKYAEELKNSKDELDVVKVMHQNELEEHEKRKAEMLSNMAQLQKDITHINDNLFSCYKVIEAQKTEQTFLRKENEELKEELKKARGDLRRLYETNSNLKSQNLSLIEINNRIRTKTLFKTDTADTCSTRGSCSSKASCVSRDEFVFFHVFNDTPLAASEFASTTRSGNDVKLNDCCSDRAVEGTMNVETLGSMSCMTKRAVTADGGPKALCDAHKSIFETTEGLPYGAGPNPLGATATSDNGDEQGGKPAEDNRSTTVYGKITPSTRDDMSARNTYTLDHSTVYSVDGSTPNYVEMSEGRGLTTDDLSEVPSPFKPKNWLLEKVSRVSNRDSLEYLREKIRLITSQECKNFSIVGDQGSQPGGCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z9</accession>
    <name>A0A061D8Z9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769209.1">
        <property type="nucleotide sequence ID" value="XM_012913755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Z9"/>
    <dbReference type="GeneID" id="24565564"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309260"/>
    <dbReference type="OMA" id="EFFFKFQ"/>
    <dbReference type="OrthoDB" id="361236at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="24066" checksum="DF7CDC8A591FEB01" modified="2014-09-03" version="1">MENSNMGLFKTRTDCRLLRNRNTIATGPFGYSVMATCLAIITAATLLFICIWPLENAVLYHLFGMGMPLVFKIWSAGTTVILFSILCRSVTPIYLLIVSCLLYFMNHMMLLAGLVQLYMRQHAANYTLFRMMYHSPQIFHFAIFMVLSILRLILTLPLLYYVMVLASIRTFGGTGWECLSSLKLEEKQLEGQRKQLEIRSEWLNLVNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D936</accession>
    <name>A0A061D936_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767595.1">
        <property type="nucleotide sequence ID" value="XM_012912141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D936"/>
    <dbReference type="GeneID" id="24563950"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205670"/>
    <dbReference type="OMA" id="QVQMYIN"/>
    <dbReference type="OrthoDB" id="365246at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="369" mass="41160" checksum="A4C51EE94C1CF0A4" modified="2014-09-03" version="1">MGANGRDLRLELVSLAVVVVTACLLSPGSWRQNRFVSWLLSSNSSFENIYQLLPILQKNSRVLFVVFNDLASAINSVAAPHNGDTPLSKESVRSLLNQEWVQLKLRKAQDSVLSEFGLDAATLDKAIDRFRSDDQVQMYINGVELMYNAVLDGGYPQCPGVERCEGVTKQFALSVVEKIAAAKQRLVRIPCSSERLADSVEVDVVFREMQRFGYTTPFDAYIAFKNAENCYLYDFAFVQARQSIYMGCKSPCSEAASSHDPDVPRVTVEELQLMLETMDADAPFFLLLFDTEHLIQEFLSFVKGSAESEPKAVVAWMYSGDSTPEYSCDRYPAALRFRGGRVEEVLYEPSGVAPYAWPAPSLCEHKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D958</accession>
    <name>A0A061D958_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766441.1">
        <property type="nucleotide sequence ID" value="XM_012910987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D958"/>
    <dbReference type="GeneID" id="24562796"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105640"/>
    <dbReference type="OMA" id="KCYLRYL"/>
    <dbReference type="OrthoDB" id="332524at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="275" mass="31565" checksum="6BA9488B429563AC" modified="2014-09-03" version="1">MSFYLMRKRCNPFIIYITTLSLWVTVTAFRYCAWNPNSLTSIDRSLLRDQRVPSVVFLPSLVGSNRRISNLRMIWCYPIVNDGPGRRNRHKVNQAFERGPTKVNLSLTYEYANRLAQNQMFAPFSGLLPFYPEEGLGRTQDVYTPVESACGRVDIDIDEFEKIKDVYRTFNDQGCGVLELVGAKGGHFAFKYCGPLKEKYGIKAYLSYLLNVVYPGAKVTILTEHAVDEVDRIGVDPWLYAKQRRLICTGSDYTESFNDGKPHEMSYPKKFDMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9D1</accession>
    <name>A0A061D9D1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor P C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766486.1">
        <property type="nucleotide sequence ID" value="XM_012911032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9D1"/>
    <dbReference type="STRING" id="5866.A0A061D9D1"/>
    <dbReference type="GeneID" id="24562841"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106090"/>
    <dbReference type="OMA" id="RSRGHYK"/>
    <dbReference type="OrthoDB" id="10259892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043043">
        <property type="term" value="P:peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="ELONGATION FACTOR P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053:SF14">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR KOW-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor P C-terminal" evidence="1">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="308" mass="35340" checksum="D0B8063DB98C2586" modified="2014-09-03" version="1">MFLMLQYADSLIFDLFVAKRFFAKRRRDSLLVSRNNIIQMYKPKHINLSELTSQEKRKARDDILEGGNEKLIKQLLSQIPLATLFKRAETRRLEPVKDLRRYPERTVRTGIADVEENVVDDTEETDVEEPTHINKIRASNFVLHKGDVHLILASQHVSQARSRGHYKVKMRNLINNKEISHSFADGTKLSVITPNKVSCTYKGVDERSGDHRFQSEGFEILVPKNSSLEKLKYLKLELKVTLSRWRGQIIGLLVPHQIQYKVTDVNPGNYAATLENGMVVLVPSYIKRGDSVDINTAKGEFLRRSIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA38</accession>
    <name>A0A061DA38_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein,Nop52 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0307060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768988.1">
        <property type="nucleotide sequence ID" value="XM_012913534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA38"/>
    <dbReference type="STRING" id="5866.A0A061DA38"/>
    <dbReference type="GeneID" id="24565343"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307060"/>
    <dbReference type="OMA" id="ICHNLAN"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="528" mass="59118" checksum="F325500D7C0AA783" modified="2014-09-03" version="1">MDAKIAQRLCHMLASCEEATRQRALRSLGKLFAQATEKVDELLLLKICKALYYMLWMTDKPLKVRRVAVAIVETQSRFTDRANRMHFFSCLFRSMSMEWPLLDKHRLDKMLLFVRVVVASLLEVLNGGGWEQGDMREFARIVLDKQGIFNKRSLGLAFQFIQVFWEEFRQNREGLLKSGEFTELSREVFLRLTAPFLQLMVTLDNKQVLNTLEMYVLKPAPGVPGMPVQGYVLACERLAESPAIRGSARKVFKQIPQGHEGAVDADQDLHKLVDETVAAIEAAVAELRQADAMGVAVATHAHGNAAATNAGASAERSANRSKESGAVSGIAADGSAEDGDVEMVPELEDVSAELQRHGADGRMELDPGEGFVSLAEAFLPRTSKKGLGKHMREIATLDRVRKFMVASGLDDHEMLKKLNSPKVRRQMALLGLHAIRSLNPDRKFKCARKLHRIVNITETAQALPSRRRSVDVAKALHNIKHTAPEKSIVRKRNRVSTETKRVVFNLKNNQVATIPKKTKSTLTMPMWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA4</accession>
    <name>A0A061DAA4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SET domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0308060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769088.1">
        <property type="nucleotide sequence ID" value="XM_012913634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA4"/>
    <dbReference type="STRING" id="5866.A0A061DAA4"/>
    <dbReference type="GeneID" id="24565443"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308060"/>
    <dbReference type="OMA" id="ISRTQMN"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="738"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="866"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="885" mass="98785" checksum="FD92F3913B221FFF" modified="2014-09-03" version="1">MRESGVCIKYPLEETTNVTRYSWFERSNLVAYEPGMRRRVSPKTSAWLSVSVAHQSKSQDVKSDGTGVSPGLSAVHREESSPVKDATSEDRYSVDDDGEGDCDLGSKPANSNLPTVLVEHRWSFLFPRSSRLGKPLSTPLFKQQVAGFGALGTSFSHSAPLRPVDGMTRGVRNEEGSSSTDGDTESSEHKVTTVQEAFNSPAFGGRSSVLRCLIMDLEMRYISRTQMNYAFHLSAIAERVIHQGVYHLANFSRRWNPVIINEPIDTYGMLRLLRLLKDVVTDDMREQEGQYDDNEDVADDVDGEPPRKFPKVSEDTGIESRMFSTGVSENVATESGDDVKDEVEGGQPFSKIRPIDAICADPLNPSTLREIYSSLIASYGGLVEDDVYASVDFESSRVYNLIKKLVGIDCPDSLISGVLECIIRDSAVDGGERKTGDLLRRHVLIERRLVLFECPPQPPSSDVDAAQSSVYCDGTEAVERICLCCSKYAVCPTVFNEYIIFGGTPAIPLDMELGIWIFDSPFTRLKMRDVPVVYHQQVQYSTRKYITIADLNDAILSTRVLNLRMEFCGRGDWVFDDGTLPLNETDKSRTIYGKVVSADDLMQLEFSGTVNQIAKKFFVLQKAFLSTGKEGTSRLIFMDPYASIDASICEDKDYVDHLVDLLTVMYKESPGNFLASCNGYYYYEDGFLPESIDVQRLRNTLFNLESSHYRTAMLADIVADQKHVLGLSQKMPFLTKCKRVMIGKSRIHGYGLFAVDTINKGDLILEYAGVVISDHMADIREAIYDRLLCGSIYMFRLDLNHIIDSTFYGNCARFINHSCDPNTATTNFSYIDEDGFGAHVGIYASKVIPAGEEIYYNYRLSAGSANREVCHCGSYMCTGYMSLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK1</accession>
    <name>A0A061DAK1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766931.1">
        <property type="nucleotide sequence ID" value="XM_012911477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAK1"/>
    <dbReference type="STRING" id="5866.A0A061DAK1"/>
    <dbReference type="GeneID" id="24563286"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110430"/>
    <dbReference type="OMA" id="WNTHESI"/>
    <dbReference type="OrthoDB" id="366470at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595619" evidence="2">
        <location>
            <begin position="23"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="992" mass="106749" checksum="5D52B68078AEE5D4" modified="2014-09-03" version="1">MVCHRAFAAVLFAACVAAFASCEQPHTSLEVYSSFQPIFLELRDESSLERRRSKRRRKSRRKHCSNCRLKSERHAEKIKAHAHDALGHSNDTKSSDSDHENHSSTSGEHVTHEGSDHASTTSEAKDHDEHKKEETSSDHAPNAEHKDDHAASVSDEHDHNKDTSGDAHSTDTTTEHSTTTDADHSSSENKHSDASASESESSNNAGQSSDSAAHGSDSSHESPDSHHESTSTSHESPDSNHESSSSNHDSSDSHHESPDSHHDSSESSTTSSESSDSKHESSDASHDSSDSHHDSSDSSSSSSESNHDASNNSHDSSESSHGSSENAHDSSESNHGSSDANNNSSDSSNDSANVNSSSSDSHAESHSSDEHNSSTSSEDNSASNDNDTSKSSENTESSASSDVKESSDNNDAAKSNDNESGEKLESKSSEDSDKSEHTAHTEEHKESGESNSESHEHKDSTSESHDGEKHADEKPADTSDSKDAHGGEGNGNESHEVKEPVALSLLEHSYEHESEAETESEQSESDSNEHHDSSDGETCTLKNGCKKGTHSSHQDSSDSVKEQESAAEHVAEDDGNSEHKADDDSDKKDGNNAHKEDDDNGDKHVEESHNTKDEDKSEKTVEHGHDMKDDDSGDQKGDNESGSDTNTENTNGDITDKDAEGEKSHDDTTSSSEETKKDSPAADSEDAHVEEHASDRVADEQKTPGESADHHAEEHAIRAVSSEAHQVALHADHRAASDVAHEGEGKAAKYASAKGEEDKSSKDEAEHEAAHHEKENAHASSEAKVEAGAHGTPQLFELRKPNMTCTIDCADNCQSMLGGKTQCFSNDDGAPRCTPFDNASTLECEGAHRPCVMPHVEPGQAFELRASTEAAPHAGEFSIKGKGFNDCISMLLISMDQACSKDNIHENMEATRAVLDPVYDVVRGDDSLKFTGVKVRSPGKYRVCLYQQYEPAGAKWSFAGLFVSLLELVHLKHHSDSVRTVYSMDAGSLVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAQ2</accession>
    <name>A0A061DAQ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAJOR FACILITATOR SUPERFAMILY MEMBER,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0211360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768175.1">
        <property type="nucleotide sequence ID" value="XM_012912721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAQ2"/>
    <dbReference type="GeneID" id="24564530"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211360"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="482" mass="52562" checksum="C1337CC6DDFDB0B2" modified="2014-09-03" version="1">MAELKSESSTATVDYNVLGQALYHLVSFFEGYDQQVLSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCLIWGLLADRHNSNFVLGAGLLVMGIASILLGSASHYKVILFLRFLHGFGFACVYPVQQKIVADSTGSGDTNNQQGTSGSAGVQSAQTSEDPKKKKAKSIFTRLQALNCIGRLLCAVITTIIARKVLLGYYGWRTSYVVLGYVWILFGTAIVFGMKNELRKNGEDLQTLIKNAFEAVFTRKTVLISIFTIFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSVAGGECIKKIVVLSEDYGELASGIAVMVVRLLVCLLFFFGKAPCGNLLWYHYIELATLGGTLVTLGGVDREIMKKSIENKYQATSSAIVRTISGISSSIILFQVSAYLTEKVFGYVPSREAFETMATDIKERNAEALRKSMMYIILAGTLLNVVCYIAMFFTYPEDKEKVNKPAQTTSGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV5</accession>
    <name>A0A061DAV5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0211960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768240.1">
        <property type="nucleotide sequence ID" value="XM_012912786.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAV5"/>
    <dbReference type="GeneID" id="24564595"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211960"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1880"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="951"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="659"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="965"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1396"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1423"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1434"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1991" mass="223978" checksum="2095399F576FC7F7" modified="2014-09-03" version="1">MAAKGSVPDFKTLKECLEFLQWLHSDKNMQYRVTRRLKKLLEKKYAKVNEQQIDTALSTFLTIVSKFYTKLCQKAGHGKNMPDKARDAFYALLQCIPKFLSVMYYLRYNVDSNFAGVGGGRWAKQQVGTLALYARLGSQMVERMKSTASDIEKYLIEKGNSNFGVIPGGFDPSDLKQIGDRDSYSEGSIMLHDLINICDKKDGQLFRDVFVTSVLSKNSGVDVSNIANALRMVEDFCGIFENVEKDDFTSHVQSRGQCINWQTLKDHCTKLKETLGKMFKQGVFSFTGYGRTYGFLDKKNIAKKMANWFRANLDEVRINLARITPFDSKQYNLKTRNKKLPQYYAGLGAHLAKYLFPYGFTFEGRSFKTGTTPYEDLKKHWDAVIGDLKKDDGGLATLKKILDGNQCANGQKQREPTPKSKPKPGPEPEPEPEPEPGPELEPEDEDDLADDDEVDSDEELMKELSDEEDLAAQKTEVTKAEAAKPTATKTEATKTEAAKPVVTKAEAAKPQAQNVENAQNQGKKAEATPNQNNGQSEEKPGSSPVAQAAEHKDSSAPSPRPASSGADVPGSGRGPGGTGSTSDSAEPGSEESHTEKNNASTLAPTGHSTGSSDGGDGKGGGSEKMCSDGSPPVELYPYGFKYCRRGDKVWDASEQKKMHDDWDEKKRNYELKLERNKKKIEERLRRQKEAENLKMEVEERIKEDERQLQREAMLPRIDVVYMPQELSENLDVAYNTAAQRHLNQFVSPMPFDIIKPTNRDAVIDDDHGTGEVNVNGSVLDGASGTQFEEFEGKPVQNFDEQSKRQQDYYSAVDITKSPGVEGYEIPDPFFSDKRQTEIDKELGKNQKDMASELQYQYYQGLGDTQSKWKQSIVDTEQAEKKERKRQIDARIQNVIERVRERNERKNKAAQNLDKKYEQTTEKIWKTQQQQNLDYIEENVKDDDAKKRLQQKRLRHQKKLEQQNISSDTPSSTDSTLPSQPSRPAPAPSGQIPFSSQPPSGIPANQSPQYVPQERSSRERVGDIEPFDLPMISVGGSAVPDFEHEEKEAKLKKLSLAKQTTEKWDWDAKQAELYKQMQKEKVNWNTQVREYRDNLHRQSHETSRTPFLSRKSSVPIVQNVDILVPPITARNISGAAIEIPAVQLDGDSALTAAAIQQPTGHSIPDSKINFRKSPFTPSSKPTGRDDSLTQSPHTVTFDDNIMLSMTGASGQPVVGVNGKVDTSQIPSDIRVNAGDRYHLEGQEVQDDKLIKRQERNIQNLQNAQMQIDSENKQRERKLQALKEKSKHINEEQRELMEAAKSDADRIRAFKDSQFDISSAPLRVDEMQFDIQIDVPKRPLQDSSYDIDLDDPYANTADILKDELKPSDDKGFSGLPNTNFNLDFAPERAGPMDYEDPGMPRDPARKTDERVINPFHTDECQNPWSVDTSSTSPTSLPSPVPTSDNMPPPKTVREMLYWFVGLNTQGYIGLISEHVKGLLKGYNTDALEVTGDPQQLTSSHVTTKLTEACLYSATVIYKIKHNNDFKAFSTFDFKSEYSQLHYSPDPAGLLCQLRDYVYACHYQLEFLKSQCSRYESHGGWKNYDYGNAVSPSDSPLHSFLTDGWDSDFDTHPFDPCNLCHKSRVRMGFKIEDLPEKQHDGTILSSILSPSCGGSDPLLTLSSYLNCITRRTPRTTGELVSYFHNFGNELHGYALKALSSLGTAITKSHADCPDWDCLGASDLQAVSGLRGSEALNMISNNNHDNEHPRTLSTLVGCGSDPANCHPRMSPITYRAYALYSQSFAHTYLSWTVYLPDRLLESLQKLHYDLQKHLGSGKCTSLYLCPVALPLLYTHGFTPPEVGSQVSLKCSDVITKLKDIVNGRPIASLMTAMDEFLYGIREPFIFTLVAMWSLAFLIFANAMLYRLDILHIRSHLIRSKASHRIDVKALLTKGRKMMSLYDAHSICQDVFVFVIFYRRSHILVYDGWQCTTMVIGCIRSWSAVPWYVEKLIKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV7</accession>
    <name>A0A061DAV7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767026.1">
        <property type="nucleotide sequence ID" value="XM_012911572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAV7"/>
    <dbReference type="GeneID" id="24563381"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111380"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="428" mass="46629" checksum="9C2F95DF2D1E6B89" modified="2014-09-03" version="1">MTLIPHPVEGPDAEVDHDADDDDDEGYGDDDVRGGNYGHLTAHIPHPVEGPDAEVDHDADDDDDEGYGDDDVRGGNYDDEDDEGDGGDDVRGGGYGHLAAHVIDHQRNQHYICNIKCHLPIPHPVERPDAEVAHDADDDDDEGDDGDDDDDDDGEDGHLTAHIPHPVERPDAEVDHDADDDNDEGDGGDDVRGREGYLADEEIADVAAHREADDAQVEQDDGDDEGNDDGGDGRVGRGGNTLDVSCQLGDQWDLDYDVCANKLLRLAVERDAEGYLAYEKIADVAAHRESEYAQVEQDDGDDHGNDDGGDGFRGKRKRRAGGRLRIAVFGTRRILLTGFKMLRIGGRIGRVLTGERLGGDRITTDSNHTVETLHIQYHTYTDPPKPSSPSPPSPLNLQTYQSPSNALTNCNTYHCRYHSPQPASISIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB08</accession>
    <name>A0A061DB08_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768290.1">
        <property type="nucleotide sequence ID" value="XM_012912836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB08"/>
    <dbReference type="GeneID" id="24564645"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300090"/>
    <dbReference type="OMA" id="IYMESEN"/>
    <dbReference type="OrthoDB" id="365580at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600218" evidence="1">
        <location>
            <begin position="35"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="785" mass="88518" checksum="949C06C06D296F3A" modified="2014-09-03" version="1">MAFRGGLPLREQSLKLLRLGVVCALLIIGQVARSREQNGYMLPIAYQKYFRNYSINLCYIPIADHPSEVDVSTAAACVDGERGPGLGIDNKEIIPAQSRANVPEQTDMQRAKVQLNFTESDLVEIMTQPKSKWYTYHLGNVYINDRPLIRLWLQNSQGVALLAHDRRSKLVFRKMDGDESNVLELQYTIRIPEADVEQNIIFKLNAKTGEIIDDTDIDRCHHAKPEMYGEYRVDTCSGDSYKCLTEMKRVNTFNQTLHVIEHFLLSPHQESRRHILYSVLYDTRNKAVIAMKTYVEYTDGFYLVNGVDHVLFDKPIAISNAASVSLGSNNEWQAPTLHPKHSGNVTVDGEDVYSVDIMPFGTMSRPSNALNAVYYLLNGIKRTLVIPKLQSRSGVNLLSEDASSYVVANIENENNQISVVYKLNIPGCAAPEAVVVRFEATQTCINLKAPDQTNLMELASVPICKSDIPLGCDAQCVVYQIQMQSKSKENAVLYTFIYDAKVRHLTAVMHRISLSKDEKINNAITEEVFYKSASYTAKVNIDINRNGFVKVSQIYAGYVSKGVYGQNIRAIVLPDGIKNFGKYYTNRFLYRGTKLVEIYMESENGVSLVNRASPPVVTKEANGGIDIVHITYSLKLLEYNTPHKVTLDFECKQVMAQSGGKKTEITLSNKYQRYRMDIDTCVIDASVWTEDTESFGGKCTVGMGEEGLYIVMSRIIKNKDDPTTGHFYKFLYETQHAIFFCKSVPIRAVEQKPNKSCRWIRAGDDRSYTYSLGGSKLIEQDISTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC89</accession>
    <name>A0A061DC89_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769848.1">
        <property type="nucleotide sequence ID" value="XM_012914394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC89"/>
    <dbReference type="STRING" id="5866.A0A061DC89"/>
    <dbReference type="GeneID" id="24566203"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401540"/>
    <dbReference type="OMA" id="YPFDVAY"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33241" checksum="25193FEF3D8030F9" modified="2014-09-03" version="1">MADITNDRLERLKQNLLKLNYKKHKKRVGEARIHLTQYLAHALPMASQRFLLAPIYRSCVASQSGNMTLYNMLRISHPTPLKILIGLHESVGFKKLWSLARVHTLSGAIYPGVLIGSRVWLGNSYSNANDTFSYAYMRTVMLCSFAHLFSYPFDVAYGRFASTLAGEVSVRTYLRETISKYGLARLYSGYTICAASTSVHLMIALPLNNHLHGKLKERLSLQIERNPAYNSTIRPLKPRGMDNSFMILLELKPIEMYPWNVIFGSFAAFIARTATYPLDTMRLGITTDGHDGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC94</accession>
    <name>A0A061DC94_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation initiation factor SUI1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768770.1">
        <property type="nucleotide sequence ID" value="XM_012913316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC94"/>
    <dbReference type="STRING" id="5866.A0A061DC94"/>
    <dbReference type="GeneID" id="24565125"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304870"/>
    <dbReference type="OMA" id="CEFMITQ"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="114" mass="12750" checksum="A4890F2AA51FE417" modified="2014-09-03" version="1">MFLDFDTAGIKDPFKQSASAENGGSNAASRLVHIRNQQRNGRKSVTTVQGLEETLDLKKMVRALKKEFSCNGTVISHAEYGSIIQLQGDKRHDVVRFLERENLVSPDQIRIHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCD9</accession>
    <name>A0A061DCD9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767681.1">
        <property type="nucleotide sequence ID" value="XM_012912227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCD9"/>
    <dbReference type="STRING" id="5866.A0A061DCD9"/>
    <dbReference type="GeneID" id="24564036"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206530"/>
    <dbReference type="OMA" id="FTIRCNG"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36824" checksum="D924518B47BB7A36" modified="2014-09-03" version="1">MAERKVLNKYIPPDFDPAALHANRDMLRNDGYGRGKTTFARRIKGGMSARMLDIRMMFPFTFRCESCRNFTYIGTKMNSKVMRLKEDTYLGIEKHRFFAKCPHCSHQIIFKTDPQHGDYLLESGGTRTYDANRDAELAAEAVSKEEDEIAEKRDKTEKMMEKADHAYAEYEELERLTALKRRSGRMRDRENAAELSLQRIQKEKEIQFVPPVDDEDVALFRKQQQEIFLNCSEEDDCDAFISSTRDDNPTYRSEYLEEIVDEGDETVLEDGKQTFSNDKKLEHNLYTSSAVKQAFSIVSVKKRCNTIVNPFEAYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE6</accession>
    <name>A0A061DCE6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0206680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767696.1">
        <property type="nucleotide sequence ID" value="XM_012912242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE6"/>
    <dbReference type="STRING" id="5866.A0A061DCE6"/>
    <dbReference type="GeneID" id="24564051"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206680"/>
    <dbReference type="OMA" id="NCIPSKG"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="585"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="688" mass="75485" checksum="A1B0BDF16E756E42" modified="2014-09-03" version="1">MTSPHCGFLFGSADNGSGDSVVLERLHLATRGAGDWESLARTLGEYRCSRRFLTEGSTLVVRRTKRSFATLARAFSGVTSTDGNDVVSDVHRRGLLSHKGDSGSSFSLTDGSIDEDDSGDPRVSQSVDEPAADAGKHLQSSRGSDAVRDSSNARGSDAHSEHAQRPHSTGASTAFYNVCSAAYELTRSFSCREPPASAGDSIEYVVVKCEPSGGYIGKNTVLYTDERLPVLSRVDLLWDVENESHVQRCVGHLLGSHHSATLTRASLLQQERIFGPYKVESIGTASKASCVRKTIFLNRSDEPRADDTTHSHGSTMQTLSATENLFRNMFSSVLMGTLSSDFLVFYPGRTLTVRDLRMFVSRTVPCTRPGIIGPSTKIYLGVDTVGECAAVSVAPLRDTLPTTYEYNLLKDCIEPYFRGRRSRTFQVDDVFRFGGVQFRVVGFEHHCEEPPLFLDFDLMSPFARRGSCGRVGARSAIKVADPVDPRLTDLLSAEQLRHLRRCAPNQRELLMFKLASQLDADSIGRLYGDGDDAQRRVPLERLETSYSGYHPIMPSTLADMVHQYNIGDTSAATVTPISGGYDQMCTVCCEAIDTTRISEIFTYACGHVFHKKCAREWINMCGTSCPNCRHCSMQMSARCDTGDAYVFHTLSDCDNTEISDNCGDSVNHESGSSSGASELLQWFNSQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCH2</accession>
    <name>A0A061DCH2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0207180</name>
        <name evidence="12" type="ORF">BBBOND_0207230</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767746.1">
        <property type="nucleotide sequence ID" value="XM_012912292.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767751.1">
        <property type="nucleotide sequence ID" value="XM_012912297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCH2"/>
    <dbReference type="STRING" id="5866.A0A061DCH2"/>
    <dbReference type="GeneID" id="24564101"/>
    <dbReference type="GeneID" id="24564106"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207180"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207230"/>
    <dbReference type="OMA" id="ANDCAIH"/>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="136" mass="15391" checksum="E72B8CF01C03C780" modified="2014-09-03" version="1">MARTKQTARKSTGGKAPRKQLATKAARKAAPVTAGIKKPHRYRPGTVALREIRKFQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSQAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM0</accession>
    <name>A0A061DCM0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane skeletal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767836.1">
        <property type="nucleotide sequence ID" value="XM_012912382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM0"/>
    <dbReference type="GeneID" id="24564191"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208040"/>
    <dbReference type="OrthoDB" id="365974at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51491" checksum="58DC9941EEED423B" modified="2014-09-03" version="1">MQYKDENHAQMHDVMGAMQYANNGQAYTVQEVGMGPSGDDMPKLYQANPFTPSFPPQKVKKNKATFPASLCCCCCCEEDVSGRGIVPQSNKSIILKPIRRERIVEVMREEVHERIVNVPQVQYVDKFVEVPKPVFKYKMKEVKRPVMVEKIRRVPKIVEEEKIIEVPEIRYVEKEVTVPQIIQKERIVEVPLPVVRERRIPVLRVHRNETYQEVDNINYNEFGTAITSVREGAEAPNNTPIKRKTEGRTNDDKLYVDTKVYNETERPHKSKQMDEVVRSSRPSIAEKPDSPTHRSSRQTHDLAQTQQTKDVKRWLQNVNEVKQMVGNNERESKQPGPGVNASSVGVQEIPFDHLQRMENNGDMKHSITVTEITSGREVHRHSKAHDTYVHDIVIENIGEGAIPGDFHMREEQKDDTVSIYPNIDALSIKSNSSDVNRHQHQVHTEGNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN8</accession>
    <name>A0A061DCN8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770093.1">
        <property type="nucleotide sequence ID" value="XM_012914639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCN8"/>
    <dbReference type="GeneID" id="24566448"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403950"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="9764" checksum="52A575B6023C9D99" modified="2014-09-03" version="1">MKLEQTSAASIQPRDILAFIRQLSISSFQWATGKSGVQPRPNRHNPMLDTPTTASIGRGGSRRFSQSVLLSDVRADTDYVHSPAAPREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ1</accession>
    <name>A0A061DCQ1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0404200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770118.1">
        <property type="nucleotide sequence ID" value="XM_012914664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCQ1"/>
    <dbReference type="STRING" id="5866.A0A061DCQ1"/>
    <dbReference type="GeneID" id="24566473"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404200"/>
    <dbReference type="OMA" id="EYSFVGY"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF4">
        <property type="entry name" value="TRANSLATION FACTOR GUF1 HOMOLOG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596221" description="Translation factor GUF1 homolog, mitochondrial" evidence="9">
        <location>
            <begin position="21"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="109"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="721" mass="78944" checksum="6EF763CB314CBC6B" modified="2014-09-03" version="1">MTVGAVVGLGMLVCLGWAAAASFHRNLTIAAFAQNTGTNGISYRNDIGPAFTLSGFAPFAPPRRAVSGLYGRRAVLYAATAEGGTDDPDATHEADQLEDQAPEEEYCGSRMRNFCIIAHVDHGKSTLADRFLELTKAVQPHEIQDQYLDNMELERERGITIKLQSALINYTYPKDGKTYKLNLIDTPGHIDFNHEARRSIAACEGALLVVDGTKGIQAQTVTTSMIAIEKGLKLIPIVNKIDVEFCDYDATASDLKSLFNFTEDEILMASAKEGFGITDILDAVVERVPPPKIDTEKPFRALVFDSQYDPHRGVVSYVRVVDGSVKKLDEVVFLGHELEAKVTAVGVMMPDLRERETLRWGQRILPDTACRSGEVGWFCCNTKDPSRVAVGDTVVLKAAAKSGDVEPIVAFEAAKPSVFAGLYPCDGTDYLQLSAALDKLKLNDHSLVFEASESSIAGHGFMCGFNGLLHLDVTVQRLQREHDVGVVVTSPSVPYRCHLKNGKQVVVSDAAHWPDDGLVKLAEEPWTNVTVRVPGDCQRKVMSLLHQMRAEFKTKNEFAGGKSVVLEYAVPMIEIISTFFDNLKSITNGFGSFDYEGAFYRAIDLCKIRVIINGEEAPGLAMIVAKDKAYDSGKLLVETLREVIPPKQFKIHLQAAIGKRVIASVSIPAMRKNVTERCSGGDPSRKKKLLDNQAKGKKFMAEVGNVSIPIDAYKAVLKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCW7</accession>
    <name>A0A061DCW7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0209430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767976.1">
        <property type="nucleotide sequence ID" value="XM_012912522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCW7"/>
    <dbReference type="STRING" id="5866.A0A061DCW7"/>
    <dbReference type="GeneID" id="24564331"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209430"/>
    <dbReference type="OMA" id="HWHKRIK"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="22682" checksum="048EF82FFFBAD80F" modified="2014-09-03" version="1">MKHNNVIHNVHRVKCSGKYIKAELDQAGRKKTRLLARRKKAAKAGITPVGYLRPLVHMPSRRYNYKVRLGRGFTLQELKAAGVGKKVAMSIGIAVDHRRTNRCAESLNLNVQRLKTYLSKLVMIPRKKTANKGFCGIPDDTPREKLATMVLSQQKIKDVMPVVQPFTAEAPRPVTSEEAAALSYKRLRQARKAAKAKKTAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY3</accession>
    <name>A0A061DCY3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767996.1">
        <property type="nucleotide sequence ID" value="XM_012912542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCY3"/>
    <dbReference type="GeneID" id="24564351"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209630"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="94" mass="10715" checksum="84FFF9B8F745D9DA" modified="2014-09-03" version="1">MVDEQRILRTLAGGWSLLSETLKSYGERVWHILILKSCPLCKVGSYGNGDRTSKTCELGCVYFVSLFLSMMIGLIYYVAKHPIFFLKGIFCCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD53</accession>
    <name>A0A061DD53_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769295.1">
        <property type="nucleotide sequence ID" value="XM_012913841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD53"/>
    <dbReference type="STRING" id="5866.A0A061DD53"/>
    <dbReference type="GeneID" id="24565650"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310120"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="10197" checksum="EB64D37278ED99F0" modified="2014-09-03" version="1">MSGYDRFNIHAQLEHLQSKYQGTGHVNNTKWEWTLNIQRDTLASHAGHYTRLAYFSICENESIARIRHRCLQNMAKPITRVKSQPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD63</accession>
    <name>A0A061DD63_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase, alpha subunit, N terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0211320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768171.1">
        <property type="nucleotide sequence ID" value="XM_012912717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD63"/>
    <dbReference type="STRING" id="5866.A0A061DD63"/>
    <dbReference type="GeneID" id="24564526"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211320"/>
    <dbReference type="OMA" id="KKKCRAF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="319" mass="35797" checksum="11E5D27C487A5B1B" modified="2014-09-03" version="1">MPGNVRLEASGVKPIFETEEHSSGRKVIDEIKNIKIKFIKNTRCHAIAEIEGLNVTIANAIRRILLAEVPTLAIESVHIYQNTGVIQDEVLAHRLGLVPFDCDPDLIPFRNIEDISGKNSVCFHLKVKCTRADLGDRPNLPIYSRDLKWVPLSTEQAELFKDHPPKPIHDDILLTKLSPGQEIDLKAYLEKGIGKTHAKWSPVCTAVYRFKPEITFSEEPLDANEVEELVQICPMGVFGAENGVFCDSNVRINYRAHYTDKAIQLHVVPRMRREVSPTVSVESTGAVPSGKLFLKAIGVLKEKTQKLKRRMADTLSYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD73</accession>
    <name>A0A061DD73_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768201.1">
        <property type="nucleotide sequence ID" value="XM_012912747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD73"/>
    <dbReference type="STRING" id="5866.A0A061DD73"/>
    <dbReference type="GeneID" id="24564556"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211590"/>
    <dbReference type="OMA" id="CNCINIW"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="177"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="440" mass="48573" checksum="E4A04EA1038BCA5D" modified="2014-09-03" version="1">MEVELSPLSDDEEGRSEDEDSTFHREIILQDNYSEADISDVPLDAEETNSNRSHTAVDEGSAKEETAAETGNNAPERRVRFASDVIIKPAAPENPPSVVFTPTNLGLHIATNYKDHAPAQPATETPNIGLLSFLPSSIIGNAVEMSKYLSEYVAAHPDLEDKLRHIPDADKRKELGEEIFPESALTNKFRTLDTTQAAIEGAASLAAKYPYPPGALMQLMHDVFVSIPTNAAVTRLGIFYVYNHLIHKFGKAWSHPISFLETGLKRFCIPAITHSNRIKCSNSVHIITCINVWRQRHIYDAATCDHLEALVTSSDPKSSVMEMQTDTNTYTVNSEVGGVNTLRHLFNMPLVDDSFKAATEGINEEDLADADAPMHNQAVADAAERGRYEAFDYASRLTGQELILLHSSSLDLAALIEEGNKQFEILQNEIAQLEAQIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH3</accession>
    <name>A0A061DDH3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0313070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769590.1">
        <property type="nucleotide sequence ID" value="XM_012914136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH3"/>
    <dbReference type="STRING" id="5866.A0A061DDH3"/>
    <dbReference type="GeneID" id="24565945"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313070"/>
    <dbReference type="OMA" id="DLWSNRW"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="303" mass="35207" checksum="3A4B38882150D3CA" modified="2014-09-03" version="1">MNRFETYRDLKLRWKRTTKSRKNRVRLARKWRQPRYVNPANPPTCTFVLHERLPQTRSSRGYGGRSGLNEEARPSSQRPYEPGEVVFDTSHNFSVYPPPEVVQKLREGYEELFCVFKSSAMHQHKAPISRWVSSVLKRQLNTGEKVTFGTVLLVASRDWTIIGKPTVPYAKVEATIEQQTLCGEQISFRYRKSRRISRFLRVRHWVTVLRIDDIVVDPEMRVDTTPVKPLRLLDLWANRWLYEEELGGVKYSGDRTVAEGTSQRSAVEMPSAIYDGTEPKAGSYNRLGLTEAYRYHPDPYAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI6</accession>
    <name>A0A061DDI6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="10">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0313510</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="10"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769635.1">
        <property type="nucleotide sequence ID" value="XM_012914181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI6"/>
    <dbReference type="STRING" id="5866.A0A061DDI6"/>
    <dbReference type="GeneID" id="24565990"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313510"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="12">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="13">
        <location>
            <begin position="129"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="14">
        <location>
            <begin position="265"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR97449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="421" mass="46105" checksum="5CC06AFEEBAFBF2D" modified="2014-09-03" version="1">MAPLDGTRCITRRDGNFLFTSESVNEGHPDKVCDQIADAILDACLEQDPQSKVACEVCATQQLVMVFGEITTNAVVDYEAVVRQVLANVGYTSDEVGFDASTVEVLVKLAQQAPEIANAVHMGRPLEETAAGDQGIMFGYASDETPELMPLSHALATKLGKRLTMVRKSNIVPYLRPDGKTQITVEYRGGTNGHLEPVRVHTVLISTQHDPAVSWPIAVDIARQVTLDRLRSDLMEHVVRPTIPAKFLDNDTVYLLNPSGTWAHGGPACDSGLTGRKIVVDTYGGWGAHGGGCFSGKDATKVDRSGAYYCRLVAKSLVANGFCRRVLVQVAYSIALSSPLSLHINTFDTCADGFDDRDLEQIVMRNFDFRVGCIIKQLDLTRPIFSRTSCYGHFGRHGDDYTWERCKDLSHEKATANHVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDN6</accession>
    <name>A0A061DDN6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">-Telomerase Cajal body protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769755.1">
        <property type="nucleotide sequence ID" value="XM_012914301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDN6"/>
    <dbReference type="STRING" id="5866.A0A061DDN6"/>
    <dbReference type="GeneID" id="24566110"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400610"/>
    <dbReference type="OMA" id="IRTWILP"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="378" mass="41748" checksum="4FCC2ADD2A72C678" modified="2014-09-03" version="1">MHLSLCCNTLLNPAVIGDSNEDAYVKSAQFSPDGAVFLAIFNDSRLSIYHTPEVDHREDKNIPDYAPATVSSMLELRCNDDIRGACFFPNFNYAVPDSCCLLIASRGNPVHLHDTQTGKRHFTYKPISRQEELVETYSLDFHPLGKYFIAGSRGTIHIFDIESPGSDIEASETPTQGVRKIYAKIGGTFGIVSSISHNPHAYNVYACGDYNSLIGVFDHNISRHESLTKPFTDSERQMGPITHLRWLNEHILLEGGRTDAYVRAFDIRGTSNAPIMRCKRTVVNNQKVTFDIKDGALVSGTSNGDVVAYETATAECQMVTKISANPVTSAQFHPTLPLLLTASGTRTFQSYKGDIDSDTDTISDSTVKLWFVSTDSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU6</accession>
    <name>A0A061DDU6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF7-RELATED, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0304880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768771.1">
        <property type="nucleotide sequence ID" value="XM_012913317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDU6"/>
    <dbReference type="STRING" id="5866.A0A061DDU6"/>
    <dbReference type="GeneID" id="24565126"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304880"/>
    <dbReference type="OMA" id="TAHNDMD"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="224" mass="24988" checksum="E31CE18834DE145D" modified="2014-09-03" version="1">MVFGLLRRAKKGAIGEPSADNKQAVQQALKMGNEAIRDMNKRMTHLDERIKECVEEAKRKHANNDKQGALGALRRKKLYEEEVARISASIMTLESQNITLEGAQMQQLALSALSTGVTAHKKLQQHMATREVDELMEQLEEQRDAQAEIHDAMTQGLSLPTEFEDELEALIQEEKMKEAAESQQLEEIATEPAERPTVQPAQPVATAPLPQATERAKTEEPIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDV5</accession>
    <name>A0A061DDV5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0402140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769910.1">
        <property type="nucleotide sequence ID" value="XM_012914456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDV5"/>
    <dbReference type="STRING" id="5866.A0A061DDV5"/>
    <dbReference type="GeneID" id="24566265"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402140"/>
    <dbReference type="OMA" id="FESNNWV"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="232"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR97724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="386" mass="43012" checksum="CC49B0B597DAA4CD" modified="2014-09-03" version="1">MTADGEAPKKRIYVDGVFDLLHWGHLNALRQSQELGGSIIVGVVSDDEARNTKGIAPIYTASERAELIRGCRWVDEVIVDTPYEVSLDFLTNVAKCDMVAHGDDVAIGSSGKDCYEEVKNAGKLVHFRRSRGSSTSTTLGRLVEALTSERFSHLSSTERHGHDALSQFRRLVEQNEAQMSREQFSDDGLQAIEMRQQKNKMHVMFPRCRTSATLFAKFIPNTPKLPNAKVIYVDGSFDVFHVGHLRFLERAKALGDYLIVGLYDDQTVRTIKGNPFPVTHLMDRALTVLAMKCTDDVILGAPFIPSKNYLENLGVSLVVTGNYSDLPLMTGGFDTHSVAREMSIVQKIESGCTLTSADILQRVSSRLDQITSNVEQRCKREKALYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE64</accession>
    <name>A0A061DE64_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0404990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770200.1">
        <property type="nucleotide sequence ID" value="XM_012914746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE64"/>
    <dbReference type="GeneID" id="24566555"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404990"/>
    <dbReference type="OMA" id="IYNDQVF"/>
    <dbReference type="OrthoDB" id="365740at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="3">
        <location>
            <begin position="194"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR98014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="288" mass="33364" checksum="5B29682540AEDC1F" modified="2014-09-03" version="1">MKSVVNQGQRKVRAVRQQCATYQNLIRVRVQLQKCSVNTSRWPHPWLSKAVSSIELAPEEATYEDTTAIQRNVGNIFLRLYGRLASLKKLNLADGDPFESIDILPRRRDEILERLDHWNQKTNVKVDKSFEVLNKSISSQVHYFLENNVDFLKKARPSKIPDNVIGYGLLQDKLGLQDCRKIILSELYNDQLFYVQLLRFLIQTGAESDANLREEEQQLRNDHSDKPRMSVAKTSKSRRLRYTVVEKLQNFVVSASFVLTKSEQERTRNKAITSPDVVDLIIRSLFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEB9</accession>
    <name>A0A061DEB9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769201.1">
        <property type="nucleotide sequence ID" value="XM_012913747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEB9"/>
    <dbReference type="GeneID" id="24565556"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309180"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="6959" checksum="E3DD04A1F850C430" modified="2014-09-03" version="1">MMTIQCTATHITTMQLSQLQYYRVSSIQYRPHNVGTAYDSCYMSCNKYLPKPHRPGDISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEF2</accession>
    <name>A0A061DEF2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769361.1">
        <property type="nucleotide sequence ID" value="XM_012913907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEF2"/>
    <dbReference type="GeneID" id="24565716"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310780"/>
    <dbReference type="OMA" id="RRLCMPI"/>
    <dbReference type="OrthoDB" id="330093at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="489" mass="54170" checksum="4E4C82EA2F33521F" modified="2014-09-03" version="1">MTVGGALEAVAKEVRSLSQALLQAERNPELFPPHVRRLRTIAAEVRQDRAKRGFNQDSLNPDSLPLERAGRVVYGLYDSRSPHLFFLASRQPAGLDVHRLFLTALKQRGNPLLDYLARTDFSLLGVYPIESIAAPGVPFAAMLRLTGVLRGPGHASCKELSVVTQDGPARHIRFRLKPIKHDFGKVLCMADAKTLRKTADEVLRLEGASNTSKVPLLEWEEKRTGAASQTQQKSKAFWTVFSKRFKASMPIMSAVDTVHVLRAFHESNKDTGVYVVAAPLLRHRTQELDKKGLVDALHILSRRIKHNTQQQLFRAMADHVPNVLWQMSAADVVATLWHLSRAGLADRDLAAYMQPKFCDTDHTLDDIGRGTAALAFARHGHTDAALFRRIEAGMSQDCSGEALFRAAWGMHMAGVDVDALLRSRVLTCLQHIQQSDSRATEVWRAILRDSDLYHTAFGQARSERQPESANPGAEGDGGSSAHYTQNVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEG8</accession>
    <name>A0A061DEG8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L24e, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0311580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769441.1">
        <property type="nucleotide sequence ID" value="XM_012913987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEG8"/>
    <dbReference type="STRING" id="5866.A0A061DEG8"/>
    <dbReference type="GeneID" id="24565796"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311580"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="22967" checksum="83D178372E2DC7C6" modified="2014-09-03" version="1">MATVTTTIKTELCSFSDYRVYPGRGQKFVARDGKVYFFLTSKAASLHKQRVKPAKVKWTPSWRKANKKFQTVVSHRRRSKKAAKYQKAFLGLSLDELKAKRATATKSDSKLAEWSLAVPPASDLVPFAQQRSVSCVAVAAVTTSNISTRSRGTSWSTSLTRSQNPKQAMLAEAKEKAKKLKGGAPKPAGAVPAKQVPIPKKITKTAMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEJ9</accession>
    <name>A0A061DEJ9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0313130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769596.1">
        <property type="nucleotide sequence ID" value="XM_012914142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEJ9"/>
    <dbReference type="STRING" id="5866.A0A061DEJ9"/>
    <dbReference type="GeneID" id="24565951"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313130"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596082" description="N(6)-L-threonylcarbamoyladenine synthase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Gcp-like" evidence="9">
        <location>
            <begin position="127"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="654" mass="72980" checksum="8487DED326213940" modified="2014-09-03" version="1">MNAVNLDGRLLIHSFVLAATCLLQLPVECVDCRARALAPSRSLLPLAQPGFLTRPSRPSPQRLLGARALPPTAHGTDVPSTYSEQVDYYEEHLRSQAPKPGSRYYILAIETSCDDACAAILSSDGDILAEERAGNPESLIKFGGIKPDELYRFHLEHLGSIIDRVVANAGVRMADVKRIAVTRGPGMTICLKAGYDAAAEISTRYGIPLVAENHLAGHCLSPFIKGHQFGISAGGDAHPSQELRYPFLSLLLSGGHSQIYVVEGPAKFHMLTDTMDTYAGNVLYKCAKELGLPISNGGGPSLEEAARKARGDPIFSMTEPCKDMAFTSFCFSGVHTQLRAMLARLRKEYGQDVTTKNPDVVNHLAYTCQEIVFQQVLRQLNKALDICDSLFGIDQLVVVGGKLLLRFSTLCAGVSCNERLRELIADLLRKRADSAGSRIRAFATRMYGNVKKAWPLKDFERNDADENILVRNLVDRMRGVRELPELLRLLWSHDLYPDLLQRREGIHLSVQHKNALYSALMQAYLSLLSDTEAYHLHRNLLDKSREREVDLQPDPRVLEELVNLERQQRSSLIAGRRHAKEEKREWQLFTTSGKYCTDNAVMVAHSLLEKHRAGLDGIPGSVFEHRVVDQWDLASRRHWEMLSNIALLHSLTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEK5</accession>
    <name>A0A061DEK5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769626.1">
        <property type="nucleotide sequence ID" value="XM_012914172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEK5"/>
    <dbReference type="STRING" id="5866.A0A061DEK5"/>
    <dbReference type="GeneID" id="24565981"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313420"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="585" mass="66998" checksum="90C84E45E8F3E002" modified="2014-09-03" version="1">MDNHQATVYLPAEDYRRVCAGDDSRLLVGWHIPVLRSTVAISSYPSCQERSLRCALQELAELPTLRHEFCRHGNLRILDISLTREHGGICMQSSDGNREPVQVVKYAVEDFGVVSFAELLTICAARQERIDAHDGGLPRQMRLSSYLITGCALLEYLDTQMHARIAESDVPKGSGDLAAFPPAHRKRHTRCEIAVNVVCQWMVQLVLYMSLCAQWVLSAASVVRCKPLHRTLNQLTIVSVISKRLTQMQQWQERYRELYLQDDIVDYLDARHSLRQSAWSVVTDVLVGVLQVLFFRRTVVYAVNYVRAALREVYVSTFKYTSYHFAMRIGKYCKLNNEVAVFVSRLLLSVLVVWRIIKPRIQAHFTVLSNIFQYSALFGVTCHTAVLVDILTIETMHVAYAHCIMLYLTKWMQRYLYSLLQLFKGKKWNVLKQSLDSNNYTREQLFLGTVIFTLLLLIYPTIWVFYCVTLLVYLPVFVARAFMRSVIEVMTKFPWYFLAYNALFPRRYKEGVYFVAHNHDTEGSSHAAADGADSDAGLDGEGLQVARPGLLLEMRCTPFSPRTVVQPMLKTLKSCCGSLNFWKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEK7</accession>
    <name>A0A061DEK7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769636.1">
        <property type="nucleotide sequence ID" value="XM_012914182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEK7"/>
    <dbReference type="STRING" id="5866.A0A061DEK7"/>
    <dbReference type="GeneID" id="24565991"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313520"/>
    <dbReference type="OMA" id="QPASYCG"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="193"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="622" mass="67049" checksum="341E197EF334D914" modified="2014-09-03" version="1">MTHSPDDIDPDSGVSYRHLNHPAHKYTLSPKFRANGGEFIALLAISAHILGIIYAILFVRSSTPPATAWITGYYGLLHRQKDVVINPYGSWRARRGGAAAASPEDARPYADLLDDVSRPAVERYLQITAQRRQSADRGDGCLATRYLEERLRNVLNGVSNDGIAEKFALDRFQSFTYVMSDAELVAQVVNAVKRFDTHGADMRLFGEPVAVKDNISVRDVPFTNGSPLLVGYKPSYTAPAVEMLLDNGAIIIGKTAMDEFGVGSATRAALNPFSTDRLTGGSSGGSANAVGGGIIELALGTDTGGSVIVPAGYCGCVGYRPSFGLINRFGMSELAAKFDTIGTCTRNVLGAARLAAAMMGPGAEVTTNDHTEHVLRGLEELISREGADDREYPLKGLRIASMDTETLVRDGLLDEDVAANMRNVEDALRGLGAEVVLVPPLPLRLATESYHTYVAAQMASNLQRFADLLYHPAGHHMSLDDVTDKMSADTTNRFLAGISILRGKHDVEAVLKRVREALVAWLEQNAIFKDIPLILSPTSARLPPYRDPAKNKSHDLLRDDLYATFAPFIGACAVSFPTGMSADGMPHSAQLVGKRFGDALLLEVAATYEKRASPFKSTPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEW8</accession>
    <name>A0A061DEW8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770191.1">
        <property type="nucleotide sequence ID" value="XM_012914737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEW8"/>
    <dbReference type="GeneID" id="24566546"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404900"/>
    <dbReference type="OMA" id="NFFEMKT"/>
    <dbReference type="OrthoDB" id="166018at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF1">
        <property type="entry name" value="PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="310" mass="34338" checksum="E4612658AA6AD428" modified="2014-09-03" version="1">MIEVVAGNSSRSLSSGGHVPGATLRRLEDESDVNLPPKSNAVVRVVDAVQRCGTTASDCDAARESSESFPVKGSASSAEPDDGSYSDDSSQSLESEQSSDLVIFDYDDTILPTYALACAQKHSVGQQLVDPNTIRDELDRLTDAVLVNLNNVVRVATLVVVTNASSDWVMQSCERYLPRIGEFFAEHNIRIISARDRLDNSLLAQKHWKYFVFIDLIEEQFIDKLKSGEPFTVTSIGDGAEERQACMKLASIFKNQKWVFKNLKLLTQPTLGCLIQQHLLLAKSFDNFFEMKTSADLCILFDKKKSQSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEZ1</accession>
    <name>A0A061DEZ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0406040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770306.1">
        <property type="nucleotide sequence ID" value="XM_012914852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEZ1"/>
    <dbReference type="GeneID" id="24566661"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0406040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0406040"/>
    <dbReference type="OrthoDB" id="361325at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="204" mass="23337" checksum="89FEF53137C7B1D1" modified="2014-09-03" version="1">MYRFENLRDESCAVESAEICSFPAYRSVEWLENHRLMPAPHGCLDHLTINPQSLSNYAHIRAYEVKANAVRTEIRNALFRQALFKIQNIEVLADNKCKKDRILRQIIKKAQPWFACSILKNKSIISEDIWQIDRCGSVQNYSVSIREVCGYIASGAILPRRGGRISLQSVSDESKKFIQPFEILLVNVKIPHDSKKTCLSLDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZG1</accession>
    <name>A0A061CZG1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0103340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766202.1">
        <property type="nucleotide sequence ID" value="XM_012910748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZG1"/>
    <dbReference type="STRING" id="5866.A0A061CZG1"/>
    <dbReference type="GeneID" id="24562557"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103340"/>
    <dbReference type="OMA" id="HKTNINY"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="556"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="710"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="752"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="7">
        <location>
            <begin position="860"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1024" mass="111948" checksum="7BE546FF3D92D86D" modified="2014-09-03" version="1">MAYNVSSLVTALSESRRFTSFASDSFRLLPSRQLIISQHGDTLFALPRPRSDKTEDLLLSEDFVQGEGREVAQDYFQRLAVEDRSAVCLLDANEENLYNETARSSKCVYSAGGLAAYAVNHAEDTLAVALCSGILALYDIVHEGSAVSLKINREFKTNTRNVTQICFDSSDAYVACGSVDGAVVVFHEGAPFAAFHHQQGHISVLRFYPKGLRLLAGTQNGDIVMYCLKHKAPIATFQDHLSEVNDIAFLIAEDDAQSGFVSCARDSYVCFWSLDVKKKDVKGAVASHNVLVKKPFKRLMQFESVIGISIVNQGLKNKGTAPWALFVATESGVLRLIDPITEKALLKRTAVYGQGDELRSATLCKASNDIVVLGSAGTLAFYSVNLELQHQLLCNVDGAFQFHLFQGPLAVDARALRRPQAEGTTRSDAPAVGNEGSVPDSTKKPSKKKASKSADKNADTRGSSAKDAMDVDSPAESGDTKNEVHSALGKVGAETRAGARDLQFSQQDWLHSLEWLNSQVAKCVPVVFILCGDDAIRLLALDGWGSCVTLGLANEKHRHMDTVLSIAYSQSGNILASGGKDERVLIWDLRTLTAVITIPLDGLNVACIALPSGISTDTTTFRLIATGNNVMKSFDVPTSWALSAPDASTVLSACSKQPLSIANAAATAVKHKKPINAVAFSHNRKVIASAGSDKIVVIYAAENLIVKGECVGHRRSVLSVAFTTVNKTVVSASIDLTIKIWNLNDFSCIKTLQGHTKAVMRVVVLPNDLQLLSVGMDGLVKVWNIKTSDCIFTADNHSDKVRYNRRLCGISVQVWNVEVAGSNLMTISGNGVLIWWRDVSAEVEAKKLMDEREEELKRTQVECLAADGKYSEALCLAMELRKPLMASKILQRRASNQLFRVEKEMPQDDLFRSWVAHLKKVEDRKKMLTIAFDFVQLWVSKGSTSWMANCLLGELIAQFTPTELFVVEGMAQRIESILSHQSSHLTRFLNLSEKSHLLDILLGYNKELSAGLNAVKISHNILYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZV2</accession>
    <name>A0A061CZV2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766129.1">
        <property type="nucleotide sequence ID" value="XM_012910675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZV2"/>
    <dbReference type="GeneID" id="24562484"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102700"/>
    <dbReference type="OMA" id="NACHEHN"/>
    <dbReference type="OrthoDB" id="365691at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="341" mass="37590" checksum="EE6E4726CCB0FB7C" modified="2014-09-03" version="1">MALNRDKEIASLKKVFKKLAHKGPLSSSYMLPVKSVFGSSNCILEIKVPRGYPDKDVEIKMLNPMPHVWANSYGVITCPDWLRKLPLVYVVEAVLTQFDGYNSSAAAAATAPNPNQHHVAQPVGQPHTGVAATAHNPNDGPEGGSTGAMRTEDNDHDASSVGDTTPNVAAESSTNVDERMLRVCRNPPTGVFQTLLSADREEVMSMLSNEDTRWKILYSCPQLAPMLAELHQLLEENEAAALAVIAAVNKKQDRLKSIEEKIKTMETMEVKPADATKMRKQYVNACHEHNKATIKALKQQIADKVKAIEQGDLSFDRCYDELSKMHLKCNELSAIELSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D012</accession>
    <name>A0A061D012_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766194.1">
        <property type="nucleotide sequence ID" value="XM_012910740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D012"/>
    <dbReference type="GeneID" id="24562549"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103270"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="8143" checksum="BEB9D6BDEF2BBFF6" modified="2014-09-03" version="1">MSLVALWRGTYITGLNSALHKRPVMTTYVCLCEIHRTTAAFANVHRSTTSTPEQALQRQSQFLTWDGFTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D078</accession>
    <name>A0A061D078_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 17">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BBBOND_0105450</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 18">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 17"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766422.1">
        <property type="nucleotide sequence ID" value="XM_012910968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D078"/>
    <dbReference type="STRING" id="5866.A0A061D078"/>
    <dbReference type="GeneID" id="24562777"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105450"/>
    <dbReference type="OMA" id="GPETNKK"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000006">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="67"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDR94236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="416" mass="44547" checksum="6010EB25FB213CC9" modified="2014-09-03" version="1">MVSTLSSKLGLADITDKLPGSRVLLRVDFNVPIKDGSVRDCTRIKATIPTIQFLLDHGVHSIVLMSHLGRPNGERVEKYSLRPVAAELSKALNNRKVDFLDDCVGPVVEKFCQEAPLGTIGLLENLRFHAAEEGVKDKVNVDGKVIEDFRKSLSKLGDIYVNDAFGTAHRAHSSMVGVDAPLKVAGLLMKKELDYFAKVLETPRRPFLSILGGAKISDKIQLIESLLEKVDVIFIGGGMAYTFKKVLHGMPIGKSLYDAPGAAIVPDIMAKAKERGVKVYFPVDYKAAADFSNDAPFKMVTEDEGIPDGWEGLDCGPKTSELLKSVVDGCQTIVWNGPLGVFEFSNFAEGSVAALDIVGEATKRGAITVIGGGDTASLAEQTGRSHLFSHISTGGGASLELLEGKILPGVAALSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D176</accession>
    <name>A0A061D176_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766752.1">
        <property type="nucleotide sequence ID" value="XM_012911298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D176"/>
    <dbReference type="GeneID" id="24563107"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108640"/>
    <dbReference type="OMA" id="WRSQRAP"/>
    <dbReference type="OrthoDB" id="361001at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="696" mass="75756" checksum="B0D293281A202C47" modified="2014-09-03" version="1">MESSADVLQRARARYADAKLAAESIMSEHMSRSSSLLKQFQGRLIAMQPHMSTKSQQSYLRSLKCGSGAPTDDNPCSSDKTPKLPTFCNQDALSSSWPSSSHAPKHMTQAAWISQTATVHSKISEISYWDDAVKIPEILMTDPADVLCGKTTALKKSHDEERDTLSELLKDTSYEMALEADVDNSHRAAQTFSQHVASVVDYSKSTPTSTEPRRDSVASQPLLGTLVNDTCTRLEGLTREWQPAKGAGTRLVDANGGLLRVLKDSCEDNKLYDIDSLYLKTFGTRSGVFNSDKGYTLTHALLHINQLDNSREAELAPKICVVRPLNEVSATRKATAPSRLATAGAVTPPPLSETAGPSNLLESVNILCEDKYAVRLHKMSEFNRSFAHVSGKGGSDVEIQTDLVSLPEPKSADPLKSAGRVKVVYSGNADRVPGLWEDVKTIAPSNNEVAAEASATALVSNVRPSLSEPSNGRAPTPTEPVPAQPPDVRARRDAYRSCLDLLDESERRSWQQKRAPLYDRMRAVERCGMRMSAVCRGGRRGGSRLTHGAPPASSAQETAWVSPTAKLTDNSPPSTLIYESPSERIRKQQEAESLVAPSVPQQVELGSPRFTRGYYGYDDMPAIKAKSAQLLDGSDFFATPGRRPSSPRAGNLKSAVKGPKRSPAVASGHNPFEDFDGWWNQHSIPLSSLRQQLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D194</accession>
    <name>A0A061D194_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Retinoblastoma A associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0108790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766767.1">
        <property type="nucleotide sequence ID" value="XM_012911313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D194"/>
    <dbReference type="STRING" id="5866.A0A061D194"/>
    <dbReference type="GeneID" id="24563122"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108790"/>
    <dbReference type="OMA" id="PHEEGCL"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="325"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="369"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="456" mass="50555" checksum="545D8BDAC0D0FC74" modified="2014-09-03" version="1">MESVIIKGNAQCKIKRRYPAPQGTVTFANRTPAFSESVPMPGMPADFPGEPPEEEYDDYYVWRRNAPFLYDALLVHRLDWPSLVVDFVADAVYKSRNGITAHKVLFGTHTSNSDVEYAVVGEIKMPVAGVRSNLTCCENFNGFFSYHKTHRLAVLGHPLPALDIKANLVHPGEVNRILHSPTNQFHFVTHTSFGDLLLFDYSRHPSTPRITSRAAPQLVLTGGHSADGFGVSWADDNKIVSVATDGSVCLWDPNAPSQAVEDTGRYVEGTKCVRPLTRFEMKDSPFNDVQVMPTRKQLYMAVSDDYVARLFDMRTDNSAGNAQVELKSEAEVNCLSFNTFNDNIVATGESDGTVCVWDIRQPKEAMLWLSHHTKSVTQVEFCPAAAGMLASASEDQHVCIWEISTEDNLRFIHAGHRGPVSDLSWLKAASMKNGFTLASVGADNAFHCYTPNFTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1T3</accession>
    <name>A0A061D1T3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766789.1">
        <property type="nucleotide sequence ID" value="XM_012911335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1T3"/>
    <dbReference type="GeneID" id="24563144"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109010"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="9838" checksum="AC9454601496FB5C" modified="2014-09-03" version="1">MTGCKCMSDQIACNKGCNTCKKWFCGCECCSNATWICLGVAVAGAIGFFGLFILVLYICSKVYKMSFGTVIDQIDYALTGYKPAASKCNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Y0</accession>
    <name>A0A061D1Y0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766962.1">
        <property type="nucleotide sequence ID" value="XM_012911508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Y0"/>
    <dbReference type="GeneID" id="24563317"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110730"/>
    <dbReference type="OrthoDB" id="365966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600523" evidence="1">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="217" mass="24697" checksum="21E6CFB174B774F3" modified="2014-09-03" version="1">MSSFVAKLYVIFYLVFSIGSISVFGDDHASTNSHRGIKLCSKYDKRHIHLGTYDGLDRKPLVITVRKSDLKEPMYYAVTADCERATGNDWMSIGVLNEEEHKEVKGHHQKYYQKILTKKFMRVITMTGRRAHGINAQPFISRNVRKPQDVNCRGGNQDNNDAEYTFPPPEGPEYAKGAIIIYPGAMEGKYYVDFAYGNPYEGPKMVCFKEVIVKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Y8</accession>
    <name>A0A061D1Y8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766967.1">
        <property type="nucleotide sequence ID" value="XM_012911513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Y8"/>
    <dbReference type="GeneID" id="24563322"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110780"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="83" mass="9316" checksum="49D16AC5357D3CBC" modified="2014-09-03" version="1">MSYVLVGEKAVDGDNTRIRAKSVTLAARIPHRHAPLIKQIRTCYEKFRRWLPTGAQYVPTVITWPGAVATLSPKPWLSLDEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D230</accession>
    <name>A0A061D230_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHOSPHATIDYLINOSITOL GLYCAN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0109810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766869.1">
        <property type="nucleotide sequence ID" value="XM_012911415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D230"/>
    <dbReference type="STRING" id="5866.A0A061D230"/>
    <dbReference type="GeneID" id="24563224"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109810"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="270" mass="30564" checksum="6B68AFCFFEAB22D5" modified="2014-09-03" version="1">MEPRPRWKRITYKRQPYPANYVSDDFLRGLSENVCNNYTLKDVCPKTMMLTQHCSTMLIMGHMFMLVKDDAIPLQYVEVAAMLVNLLFCALMYAASRTKIGEWHASPDIMQSDRFRHVIFAFVVQLALQLLQPVFQTLTSSFSYDTVYEDYVRDVDALPMNCLILVAILVSSRFGCPQKVSHSQTDVTRRRTFSVLPLLQRFLMESKSVPVIYGSTAAVVLATCSCLYACHPALVPVYILGRAATYPGDGIQTRSPKIGNTIARSPRKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D256</accession>
    <name>A0A061D256_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion degradation protein UFD1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0110010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766889.1">
        <property type="nucleotide sequence ID" value="XM_012911435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D256"/>
    <dbReference type="STRING" id="5866.A0A061D256"/>
    <dbReference type="GeneID" id="24563244"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110010"/>
    <dbReference type="OMA" id="SDKFNPF"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="215"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="295" mass="33821" checksum="9BDB8CC97C631978" modified="2014-09-03" version="1">MVSTCPYWRVIPQLWICVVVFLLRSLPLCQTLRKSHSSRPVAPQGHGFLSFDRLWRSFDRARVESYVRDVNLQLQQRPGIERLLIVLELGEPFARHCRSADGDRLLLANSDKVSLPESILTQLTDTNAAVPWQFVIQKVHRCQLTNKSDAKGAKLPSTNNDFFSKEDGPKERLSCSSLEFRPQDNFIFMPRWMMESLQLKPYDVVHLSQHKLPDATFVKLAPLETSFFELPSPKSVLEEHLKHYSTLTRGSTIPITHNGVTYHLRVLRIETEEIKDAECASIQDTDVSTDLVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D273</accession>
    <name>A0A061D273_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767032.1">
        <property type="nucleotide sequence ID" value="XM_012911578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563387"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200030"/>
    <dbReference type="OrthoDB" id="366456at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1508" mass="168804" checksum="F4011B50F91FDC56" modified="2014-09-03" version="1">MQLRYLTRKNTPVVEGVGRYNKAVEQSNKKVSEKLNSFTGELTLLKEASDKILREHDDSRQKINYKDQQVEDATKQIDAKLKEFQQRAEQFTSDIDTTVADNELKKSIVELNDKLRDKLDNVRATVAYESERLETVRAKQQSELDTTKQYISQTLSSLQVNVECNIQDQVRALLDYLTKEVRPILAKLKQINNSLQICLKHLGQWIDNAKDAITTAETQVNKILECIDEGSLYKYPNQITQAAQQIEASTSILHGKFEELRNQYNAVVTKVKGPEGDGKGECAVKKLKELEENMIVPHQFSVFNQTSGEWDVSTVIKPLIEKIKKNVGNYLEHLKEALVAGMTAQNGLVVTSKKTPGLDAMIKKLGENNLKNKLGTFGVLFTTAQIANEAGNLGYCFEIVLNYLNSITTMSNSGWNTFAGRAGTTLKSSMQEKAAGIEPDIGTLCNAAAITGAAKLQKEVTVIVEKYLDVINKLDGTLEGNAEVEKVALQTHAQDVMNKIKSLCKDIRNVTSEDPDSAKAKLFELKTKYFADSELATNSINKIHSELGHLRSDLESGPIKAVEKFLKDAEVTEKHYVQAMQRYLKTQVNVAETALTTHARRRYVDSIKWLLEQFVEKVKLELSELPTQIEHDQHIGLKGFMEAFNGNDSGDNVNRLLSNSDIPTLCRSLETFFAPVKSYIDSEINRLDEEEHKKHPSLPRSQDPYTSKLTKLYAALSGLISHVYTSNKYDRDLPTKLDDLTAAVADLTTDGFPNPVTAMLQGVSGGCRELVGALGKVYISRYDGANVRWEHDEKAVNNCAKAFLTIGPAYFHGLHHLFYKGATEWTDYKVTGNAKSARKADELKKYLQEEGYDIDQLKDQTGKEVALRMSRGFARYQSFNENPENLGTYKEYLAHYRKYEGLLSRLFYYLDAYNHVGHLVVHPRPRHPSSVFDILLWLNGLPYNPVYHALSYDGFSGLFEKEEKIGDATADDDGPTFEGEEADTLPAYPKDITAASLADKLTEVTTYAEDVLLSILGYGHNDGIYACDFYTNAGKLAYPSSAAKCLDVLVELLYRLFHQLRFLYEQCSNSTQYSGWAECWYGQGVGGSSWKCNEKQCADQNCKQIADQTANQTCKQHPKCGVKSPLQFFLEDGLPGFLPHPYNKADCKLSCSAPNHFGKPCKTPMGFADISITASHTSKGSRLYKVLKEFCGTPSSPLTVLCSSLVCVLGRPPQTLGDMFAFYHLFITTWNDGGKKHKKEAFDEAVTKANLQRPYDELNVASVFNSSHSGKSKTHTSGDLISLVCSSKTAATCGKYLSPLSNDISATFSFKHADKYVSWMVYLTETFYILLQKMYEECNSKCGGATPKCRVAKCPKKCKANEKSPGSTHHSLCDSIINCPSTSSVLCTYGFTLVDRKKLSGTDDVDYKRTCNDLCNALKKVLDGESVLMQLFHSIDKFIYTIRFPFMTLTLALWLLSFLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2A4</accession>
    <name>A0A061D2A4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translation elongation factor EF-1, subunit alpha protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0200430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767072.1">
        <property type="nucleotide sequence ID" value="XM_012911618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2A4"/>
    <dbReference type="STRING" id="5866.A0A061D2A4"/>
    <dbReference type="GeneID" id="24563427"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200430"/>
    <dbReference type="OMA" id="IERYEEC"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001202">
        <property type="entry name" value="Translation elongation factor EF-1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="107"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="546" mass="60897" checksum="9EB437603A2EC2D1" modified="2014-09-03" version="1">MADGGINHAPKSTFTFNVNAAEFTPSGSWYNYDQQEEKEKEQEMEKEVTEKLETLNVNEGEPAPEETEAVIAEVAEEKPAPPTEAKELSTKKKGGPTDSGVPPPDPRQHLNIVFIGHIDAGKSTTCGNILYLTGYVDERTIEKYEREAKDRNRESWFLAFIMDTNEEERQKGKTVEVGQARIETANKRFTILDAPGHKNYVPNMISGATQADCGVLILSARKGEFETGFDRGGQTREHTLLAKTLGVSHLIVAVNKMDDHTCDWSEARYNEVVQKLRPFLKTCGFVEGRNLNFLPISGLVGQNLMHHVSDPSYKGYCPKASWYPQTMPTLFQLLDGIDTAVFDDKAALRIPVTGAYRDNGVICMGKVESGTVTSGQTCIVMPHKVKVKVQNVLFDEEEFAYAKPGENIRLRIVGLDEDQISKGAIVCDVDRPCPVVTEFIAMVQIIDLLEHRPLITSGYFCVMHAHSVVVEMQFHKLLETTDKVTKKKKLNPTFVKNNTLVTAHLKVSSPICLEVFDTCQQLGRFTVRDEDKTIAVGKVLKLLNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2B2</accession>
    <name>A0A061D2B2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb-like DNA-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767082.1">
        <property type="nucleotide sequence ID" value="XM_012911628.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D2B2"/>
    <dbReference type="GeneID" id="24563437"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200530"/>
    <dbReference type="OMA" id="SCSCYCK"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47340">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47340:SF1">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="1341"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="1758"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1821"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1643"/>
            <end position="1657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1841" mass="207066" checksum="0FAA178FCE3A62ED" modified="2014-09-03" version="1">MDRRDVPRGTPASLECMSPSLSLLRLMSGINHRAHELFMNRLSQRSSDKSVRSPMSRGYGSRGRQSPRASGNTIMAPSPRAALNTTDDAVTSPWPKRMHTPQESPMARTSGGSGSQGVADTAQVGSTATPTRKQDGYSLLSHCRSSSSSLRFNPASLVSLPFGYCNNTFVKIRVDDVIDPRVGRKRTKRDYSSSATATQQQPARRGSRQAAVQAPSLAHMTDDEDLLTHYEYSSNPYKRRYCSSVKYRRRTERIDTGGGEDGMQAVHAQRHRQQRPYTRKTSEHADVGVEEQLPEVSGAESGTDTEDILPVITPATQAPLPLHDQDRGHLKNMESAAKRVKREMVDQMMDVVQAVSVVKKRLIGKDGDADACPEQAGLPMDSETLAQLEDALKSLVRETRHNIVALQYSKLLLNWHYSPDVVDGVKQTRENSPGRSVDITDDAENGNPELNDSFSQYRGVVTASPCITFSDGLACVQGLCSTSKQSFEAQALTDCYTAAGCYVWEHQNEKVPEGKLPNDGKHCTGDLEPSICKVESADAICNINGASATRQIQPSDYAEGAEYGEALEESDEEGLGKTGPWTSDPDFAKSILDSNLKAQFNAYAGFLKDVCHSAIAEVRIPRPEWVGSSEHSCNNDMCCPRCCTCKDTCTTEYKRTKHSGSSNANDAESLRFEVETALARTDMLASMLGKCVCFCNCLSDRRLIDRVIHDNSKNRRQGNSGIVWHDMECPENMLDAEYPNLPREGVLQERFTLRIKAEHIPLSWKQRSPFVCKLDIITDAIKDDVHSNETPDHTDCGKDMPSELGLHGAFNTNNPSDGHTISQPLTCDGGNLSGGNCALFSQGSPDTYDRNANPEGITQVEDAPMLKLKEFKDLSSFTLWDAVDTLAKEQRELHRILRKNEFTDCFDALEIDVSQLTREKLKLSSECLIDDPNSEDYVEIALYLPYAPSCIMPWRFESIDTLEIMSQRFKRAPRVEVHRSYGVLEDLEGMCPPDSDERTQSEDIMLDECIMDRSLVMLHHLDELVSNTPTNVRVYDDVSSNSGAGTLVESSATPYADDASTIGTDTSSPTIIKDFVDANTNGDSETLACSELLRDMVVVPLCVKRVLQVMREHILVRNEILNAEAHACKLYKRRWHHYLRRMKAAAPKVDDFAWGVLPVRALDEPNNFVPLPAGFKQNDINWPYITNNVLSPFEVNSYGIGDICNQQQRFSTLAQNARDDKEMEMSDYQQIHTTRKPNAGRRRLGPEAAVTDNYEDDGSRAPVWLAPSYSNLTGPGLRWTYSCMDTLSDPLHCIPNFKTVPIYQIMTSPDYNYYKLDHCVQYDRRNSLPSEAVLAEEINGRISNVWTRNECRIFVEKYLMYPKNFAKIAQFIENKTCGDCVSFYYKYKYRLKLKERINDMKSKPKNKYDVSRFVRRDAHVMQAIDSILDDCYTDSVKSLCEQNSFAFTTVNDHLLSTAVVDNVKPYDVALTEHRGNWSPMEDSFQLMLDNLNEGYFVPTKFRCLTTRKNMQLPLKTMPGDAETTLRRGCLIMNGCRDFGDPQQLSSVMSAVKTDHFMSLKPICSKKVAGRSVLEAVMQDTIADQQRIDTRVGANVMQFKRRYSATLVDGTSDMEDTESHDMNYADDSEQYDSPSPDWNRAEDTPEYSAEEEEVEDSVSEPVTPQYETQSDEENVQDPMGYDAYDSNVEESYQAMDESHRSSGYPINAPAFTAHQESRTSHVVENPRWMERSQLQDVHVGNYDDGESAEEAETYNPTQAPQRTVVDWSEKEVAAFVRLYRIYGEDWDIIESQMARYGRTKEDIINYYIARLTTNALKRDGNRYQGSDYGYDKDDDGDAYHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2H9</accession>
    <name>A0A061D2H9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0201380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767167.1">
        <property type="nucleotide sequence ID" value="XM_012911713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2H9"/>
    <dbReference type="STRING" id="5866.A0A061D2H9"/>
    <dbReference type="GeneID" id="24563522"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201380"/>
    <dbReference type="OMA" id="AKVYFYF"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="270"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="518" mass="57512" checksum="5CCE9D77DAE58B85" modified="2014-09-03" version="1">MAADEQKAPAAAASSLPCDAFRELLAHSTALLEAAVARADGRYVVRLMRHFKTLRSLLKNYAASTLPVLRQAIAVYAHGSPGCSLASLALELLSEDVVMAPAKEGEVNVRVHLTVAPVLGIEEYLAKNTNLDETKILLLTLALIYLMDTAQIAEAMRLAEDFAKYVLDFNKRSIDRLAAKVYFYYSRVFELGGRLPETRTLLMSAYRKACLHHEPMTEAVTLNCVMRYLVQHRLYSAAATLLSKTSFPDNLSSNAQYARYLFYYGKILAVQLEYSEAYNKLMQALRKAPQADKTAFGFKLAATKMTIIVALLMGDVPSKSTFTNPQMKGSLAAYEKVVIAVMNGDLAAFSNVCDNYRAQFEKDGTLFLIARLRHNVIKGGLRKITLAYSRIPIEKVAQKLGINSIEDTECIIAKAIHDGIIDATIHHDEKYMQSKANVNIYASDQPMRAFHKRINFCLKLHANAIQAMRYPDEPDIAKNTTPSDVIDEEQIAAVGGRRTPVMTWQIVEEEGLGDGDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2T4</accession>
    <name>A0A061D2T4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0106960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766573.1">
        <property type="nucleotide sequence ID" value="XM_012911119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2T4"/>
    <dbReference type="STRING" id="5866.A0A061D2T4"/>
    <dbReference type="GeneID" id="24562928"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106960"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="10">
        <location>
            <begin position="251"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="9">
        <location>
            <begin position="329"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="504" mass="57630" checksum="54DA9DA8FDD03535" modified="2014-09-03" version="1">MGDWYTGTFAAAEPSYAPMRCCLCGDVVAKPTASRMCHLCISKNVNLSQEVATHCTILQCGTCKKFFHDRWLNCEMESRELLSICLKKVKGLDAMKIINASFVFTEHHSKQLKVKICVQKEVDNSFVVEQTFVIDFAIRSSQCDYCKRMYTPHTWKAMVQIRQKTKDKRHILMLEQVIIKHNAHENVSSILSRRNGFDLHFQSKTCAQKFADFISDKIVSQVKNSKKLITQDSVNNKWDYKYTLQVTLIPICADDLVFLPPKVASMNGGVSPFMLCVNLTTTISLIDPFTLRTLEVSGDKYWKNPFSSREFSSPNAAHQIVPVFTKFNLCNFIILNVEKDRESKNTHPYYELVDVEIMAVNSSTVIYTKSHLGKALAVGDTFSGYDIRRINMNGLAEEETDITNKIPFDVILVRKVKNKRAFKTNWVLKRIVQTKGGESDDEIEEDELLDFKEELMNKKELQRNVDFYQNPKMQVSKDGSAEGGELDVLASQLKELSLQDTNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D360</accession>
    <name>A0A061D360_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767377.1">
        <property type="nucleotide sequence ID" value="XM_012911923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D360"/>
    <dbReference type="GeneID" id="24563732"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203480"/>
    <dbReference type="OMA" id="FTNIVHC"/>
    <dbReference type="OrthoDB" id="365248at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="498" mass="56776" checksum="29ED15AB44137066" modified="2014-09-03" version="1">MATDVRPVNNAAYRGRNMERIYPLILCACRFVLSLTQFSVAMDTFVLLREMNRMPEYDYDMSFNDLASTAQDYDWVPTYPKSGSMPSNYGQNKLFNLFIIRLTHFLHRQLGQLVIYPSTLSLFFMTILSVYDLFEFLQKRWSPVRVRRLGALMQKIFYYTTFLVITVQLVTMMYESSEICHMEILYPYLFRFRSNTKVHQMLIDGGVRSLKGRLVACILFNLGSLVPDTYLILVRTLQPLRLYVIINALKVAGGTLLFSTFITICIVRYFINAGTDPRLFADDTPSQLMNKGVAVDPSVANTSFISDNLKYLPVYNLKDTVYSRVARTVAGMEKNKLSVPDFLKTPASKPTEAAVTFQNKLAIYNFIRSNIAQVVTTLDVVLYQSLYLTVVCMALGLYGFVLVIKRHKLILYVNFMVDVIAACVHACHALMLMYGMQVAEYFCGIDVYMPAEGTLSLGTKAVFTWMCRSKALYILMFVIAIIEAALSVTDCVALYLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D381</accession>
    <name>A0A061D381_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0202200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767249.1">
        <property type="nucleotide sequence ID" value="XM_012911795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D381"/>
    <dbReference type="STRING" id="5866.A0A061D381"/>
    <dbReference type="GeneID" id="24563604"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202200"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="325" mass="35634" checksum="2B83B536D1C8B982" modified="2014-09-03" version="1">MGVEATLICVDNSEYSRNGDFSPSRLAAQVDASGLIASAKLSEHFENTVGIVCFAGRGSRLIAAPSNDLGTFLSGLQLVTPYGESEFIKGIQTAQLALKHRLNKSQQQRIICFFASPIKEDRTHYVMLGKLLKKNNVSIDIINLCNDVATEEKLAALHAAVNNNDTSHYLHCKAGGDMLLSEMILNSPIMQGTDVGGMAAGYNSNLGDFGVDPEMDPQLYMALRMSLEQEEERVRKETAKHAANNGAEHPTQTLTIADVENQIKDMAAIQIVPLPRVMEMVMTSEGNPELLESLIYSLPEVDLEDERFKELVDKLKELLPMLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3N2</accession>
    <name>A0A061D3N2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767379.1">
        <property type="nucleotide sequence ID" value="XM_012911925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3N2"/>
    <dbReference type="STRING" id="5866.A0A061D3N2"/>
    <dbReference type="GeneID" id="24563734"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203500"/>
    <dbReference type="OMA" id="TMNIHIH"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="622" mass="69173" checksum="2B23831C2944BA2C" modified="2014-09-03" version="1">MEMDLHSLQLKAVSEMLQLSGDDDADGQQLKTWKVLIYDDEARKLLSPILKVGELRSLGVTLNMAISDRREPIPGVDAVYLVSPTEANVDAILADAQSHKYKQLYVNFTTYTSDAFLSEFARRFVEAKAHGSIAAVADRYIHFASIALSSFSLNMPKCFAECYGGRTEGETDPLLDTIVDRLLSVVVTLGTLPFLVAPRSMSPAATVAERLNKKLFELVSARHQLGISLASSYNRPMLLIVDRTIDLGSMIQHSWNYQPLLHDLFGINFDKLVLETGSEKSKKVTYDLEAGDKLYQAIHRLPLSDVASHIATSLEGYNAQLSQINRGEDEAAGSLVNAMNAIPQLTEQKRLLDMHTNLATALVDAVKSRDLDRFYEFEYDLDLLSEKNCFQQFEDLLGSDKSTAMDLYRSLLLVALNRPGVAESRFDELEHRIKLRGELKHDSLRGLRNLMKMKAFSEGLLKQIQNAKTSDLSTAKQINEGMTSAEAPRREFSQGHKKLAEYSSKLIDTGVSLFKGVRRMLPRKKQPCIVSVLESLLNNSEAISSEFAYYDPRTSESALAPSVRRSTSRRCVVFVVGGGSYNEAVALQDLASRSKYSIVYGSTAFDRPEDFMEQLGGAAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3S0</accession>
    <name>A0A061D3S0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0110100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766898.1">
        <property type="nucleotide sequence ID" value="XM_012911444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3S0"/>
    <dbReference type="GeneID" id="24563253"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110100"/>
    <dbReference type="OMA" id="RHQTIEY"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="249" mass="29105" checksum="C4AFE549936F5C83" modified="2014-09-03" version="1">MSFLSRILWAPPKSPRNIYFPWQTMCVHRSGAFLERNRLALRVPINLTKFEIREYLRKLYGAQVIKVNTLIKVPRIKRDLASRKPKYYRNGPMYKKAIVTLEHAVPDEVKMLGRDFELGVNPAITKKNVHYGKKKDFSYLPDRRQDPLTGEIPYGWRLPIANLLADDDWEMHPELRDESDHLRMSPDPTEPHVHGGAYTGTKKPEIVPEQTYTMINLTPWRRKLQRQEAAEKDAVGPATPTPWRFPKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D410</accession>
    <name>A0A061D410_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766973.1">
        <property type="nucleotide sequence ID" value="XM_012911519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D410"/>
    <dbReference type="STRING" id="5866.A0A061D410"/>
    <dbReference type="GeneID" id="24563328"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110840"/>
    <dbReference type="OMA" id="FYPQCNK"/>
    <dbReference type="OrthoDB" id="70850at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38585">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38585:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595762" evidence="2">
        <location>
            <begin position="26"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="434" mass="45845" checksum="2BC0F23D4CEC0931" modified="2014-09-03" version="1">MYVIGSCCVAAAVIVSSTQLSAVYARTSDVGGSLPVVTEGLIGCADGSEGVRCSPESSEQPGSLEDRGITDAPVTFRQADLPMLSSLIGRCTACTRYTRTAAYGGQAIALNAIFTALALLAQRLQELLDIDTGALLLGRLTGLLTVTIGGYAAYKLSEQLLELTLAALSSGSASRTCKEILAHLRRRASRSITAPLGAIAAVGHAAQTCTVVRSAAKGLAPRLTPLAAAMRDVSGVRYARAAVPSWLSYSDTSVKEAAVIAAYCISTFLLLGGSLHSFTPSNVTHPGAFAVPSTSLSAEGYTYANRRQKRVIQQLGRTYGCHSCGRSSASGQYIADHQPPSGVIKRRLRRPVVKLLVDHHIVPLSLVRPRQYFYPQCPACSAEQSNAVRTNRKKVVTHYGVFRPYYLCASGYLAAARHALALPVPAPAESFGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D476</accession>
    <name>A0A061D476_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767732.1">
        <property type="nucleotide sequence ID" value="XM_012912278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564087"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207040"/>
    <dbReference type="OMA" id="QGNRQTD"/>
    <dbReference type="OrthoDB" id="367101at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595439" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1389"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1610" mass="170723" checksum="5BDFAF17CD067A31" modified="2014-09-03" version="1">MKWRISVLLLLLRAIHVSAEISAPAAPSHTEDKPKIEPFIAPKLVDDTTPPTKKPSTPGRKPAASNGNPTPSDPREKGEIKPSKVLPLVDDTTPPTKKPSTPGRKPAASNGNPIQTDPRKKGEIEPSRVPRLIDDTIPPSKKPSSTGHKPVASNGNPTPSVPREKGEIHFSRVFPAVDDTTPPTKKSTNSGKIVTVSDFNPGPADPREKGEITPFPVPHLIDDSTPPTKKPSIPGPKPVASNADPTPTDPKGKFEIVHSEVLPLSDDTDPPKEEISTDDATDNAPADAPSPSEHREKGEGRTSHVLPLVDDTTAAKKPSSPGRNSPAPNGGSEPSDAKEKVEIERIHVPRLVDDTDPPKEELTANGDAVDTAGNGDPTPEDPEGKVEIRRIVVPHLIDDATPPTVEQSIHGKNHDVSNGNSAPTDPRKKAEIKKIDVLPLSDDTDPPKEEISTEDGETDNATADAPSPTDPKKKGEFRRSGVLPLIDDTTPPIKKPGSTGRKPVASNDNPTPTDPGEKRRITHKRVLPLSDDTDPPKAELSIDDSVTDNATADATSSTDPQGKVEIEHFHVPKLIDDTTPPTKKPSTAGRTPVASNGEPTPSDPKGKVEIRHFEVQPLIDDTTPPKKPSSGGHKPTVSNGNPTPSDPREKGEIKPSIVPKLVDDTTPPTKKPSSTGRKSVAFNGNPTPTGPKEKAEIRHVDVLPLSDDTDPPKAELSIDDGVTDSAANGNSTPSDPKRKPQIIHSDVLPLIDDTTPSKKPSSGGHKPTVSNGNPTPTDPRKKAEIKQIDVPHLFDDTDPPKDELSTDDGVTDNATADATSPTDPKEKGEITPSLVPRLIDDTTPSTKKPSTPGRKPAACNGNPTPSDPREKGEIKPSIVPKLVDDTTPPTKKPSTPGRKPAACNGNPTPSDPREKGEIKPSIVPKLVDDTTPPTKKPSTPGRKPAASNGEPTPADPREKGKVEHFSVLPLSDDTKFPKNEPFADAVAPNSDIAPSDPKDKAEIEHIHDLPLSDDTDPPKEELSTDDDATADTPSPSAHREKGEFTPSDVLPLIDDTTPPKKPSSPCGKPVASNGDPTPADPKEKEEIVPSRVPHLIDDTTPPKKPSSGGHKPTVSNGNPTPTDPRKKAEIEQIDVLPLSDDTDPPKEELSIDDGVTDSAANGNPTPSDPKEKGEFTPSGVLPLIDDSTPPTKKPGSAGHKPAASNSNPTPTDPRKKGEIKPSGVQPLIDDATPPTKKPTNSGKIVTLSNVNTGPADPRENVEIEHFHVPPLIDDTTPPTNKTSTPGRKPAASNGDRTPADPREKGEIEPSIVPHLIDDTTPPTRKPGNAGHKPAASNSNPTPTYPKEKAEIIHIDVHRLSDDTDPPMEELSTGDDATDNATADAPSPTDPKEKGEFIHSRVLPLIDDTTPPTKKPTNSGKIVTLSDVNPGPADPREKGEIKHFRVLPLIDDTTPPTKKPSSPCRKPAASNGDPTPADPKEKREITPSPVPRLIDDTTPPTKKPSTAGRKPAASNGDPTPADPKEKGEIEPSGVLPLIDDTTPPTKKPSSTGHKPVASNGNPTPADPREKGEIKPSRVFPAVDDTTPPTKKPSSSCRNKTAIRRRIRCRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4F3</accession>
    <name>A0A061D4F3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L44 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0200890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767118.1">
        <property type="nucleotide sequence ID" value="XM_012911664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4F3"/>
    <dbReference type="STRING" id="5866.A0A061D4F3"/>
    <dbReference type="GeneID" id="24563473"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200890"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="105" mass="12001" checksum="71517B7EDBE39C0D" modified="2014-09-03" version="1">MVNIPKSRRTLCSGKCKKHQLHKVTQYKKGKDSVHVQGRRRYDMKQAGFGGQTKPIFRKKAKTTKKIVLKLECTVCKKKHFAKLKRCKTFELGGDKKSKGSSASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4K3</accession>
    <name>A0A061D4K3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0101980</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766055.1">
        <property type="nucleotide sequence ID" value="XM_012910601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4K3"/>
    <dbReference type="STRING" id="5866.A0A061D4K3"/>
    <dbReference type="GeneID" id="24562410"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101980"/>
    <dbReference type="OMA" id="VQDENMA"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000826">
        <property type="entry name" value="Replicative DNA helicase Mcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="424"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="772"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR93869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="946" mass="106810" checksum="40D27184963A663E" modified="2014-09-03" version="1">MPGESSARADSAVYNSQTQRRQHTHSQGMTAGDVDISHEEDAANIQDANISTVFDFFLRSYVAEGEQAYDEDLEEFDDSLSDDEDTTGTYCLNGDTSKPLFYMKRIFTLVSRMSHFSEVLVVHLDHVLNWRPPQNEASLNLNMQLYKYLVKHFLRVQDALEDKLQGIVDSIAQSLNRESKKLFLQFLHSPSVIHPLKEVRCHMIGELIAIRGQVTRTSDVRPELIRGTFKCKACGNTIENVRQNFKYTVPVKCTSNNCLNMRDWELVMEQSLFCDWQKVRIQEMAQESDTSAMPRSIDVILRHRSVDRLNAGDRVIISGTLIVLPDVPTLLKPGEMPRKVNKQSMRRFESYLISQGLTGIKGVGVKDLNHKLSFLATQVRRVNDFKSTAGDVIDTTSDVQVRADDILNLSNFDWIRRVARGHNTVERLASCIAPKIWGHSEIKKGILLMMVGGVHKSSSNTKLRGDINVCLVGDPSTAKSQFLKFVESFAPRAIYTSGKGSTAAGLTAAVHRDPDSGEFVLEAGALMYADLGICCIDEFDKMNDRDRVAIHEAMEQQTISIAKAGIQATLNARASVLAVCNPRYGRYDTSKSFASNVNLPPPLLSRFDLLYTMQDEADEMVDAKIAWHITGLHGPGVYKSSDLIEDHAEIEHQESPFDQEFNPPLTLDELKLYIELAKRIKPLMQDAAKHKLAQYYVGLRNGDAQSTKRSLRMTVRQLESLIRLSEAIARLKFSDFVEESHVEEAYNIFKSSLLRLSNKDLVVLDEERARTDDVDDGDEEWTTSTRRRHGAETGADEPSATAHADLMKISMSEYEAISAVLLDHVSENQLMENEIASNELVEWYIQNVVVPRTPEDADAWNLRLQRVVHRLLYVDKKLLARRVQTDIPNVFRLRVHPNYYSSAHVWRRDTMAEEQDVASVDEDDHSAAVASDVDDVEVIEPTEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4L1</accession>
    <name>A0A061D4L1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767173.1">
        <property type="nucleotide sequence ID" value="XM_012911719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4L1"/>
    <dbReference type="GeneID" id="24563528"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201440"/>
    <dbReference type="OMA" id="VANSHIE"/>
    <dbReference type="OrthoDB" id="366212at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="525" mass="58099" checksum="6E7D2C2105A75113" modified="2014-09-03" version="1">MNFIKGIVDGILAEDADPDDRRTAGYRAAHGAPRAEHELGSRYTDSLARELESVYREERRNCITSLIVRYGEGCVQQLNELLKTNNRTIADLSKQLDDAYRSLGDFNSDLEELSQENVALRRRNAELENQLELLNSENVSLKSLVEQAEIEAKSQERRIGGMAELLKQNAATFDGMRDRCTAVAEYAAQIESLKAQLAVANSHIEALTKERDALVEAAPDAEHRIKEAMRKQDRALSIAKLMAQEAFYLSAQNAQLRNQPAAEISQQQYSQAVLQAEELRTHVEKLNDENGHLKDVNEKLHNMYADLSKSSKQLKDSFLAEAIQALGARHLKQLAPVQLVFIQPTRVLDLDLDLDFVRAELARSMRSPYQQSSVRMDSGAFDVAREAHLMRPASAEPATPASSSAAFGAASHARAPQPAPAYAESVTPTARPARPNDFVGKKSWDDDFDLYDEILHEEDAAAEEPQPQPAVAAQAAPMPDPVRSPVQQLVSMPTTPVALAADVKLDLTKSKGAWDDDLDELLNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4N1</accession>
    <name>A0A061D4N1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767193.1">
        <property type="nucleotide sequence ID" value="XM_012911739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4N1"/>
    <dbReference type="GeneID" id="24563548"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201640"/>
    <dbReference type="OMA" id="NEREWQD"/>
    <dbReference type="OrthoDB" id="366021at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600046" evidence="1">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="437" mass="49064" checksum="2641F2D3CEFE720A" modified="2014-09-03" version="1">MLIFPLLFHVRCTPVVTAVRIELENRAGSRSNASFTPSSLPLYPLDFQDNWQAAQPIPVDVNFSVPHFGPRDLANHLEELSRSSGALTKQVRHDNSQLTLRQLNEREWQDQNIEAAEDRSAVLMPYPDLEFMPLQSLRVLASSMEKMKHGMAAPYNMPNLHADAVLRLHAIQKVNHDLLTENARLRHRTRDMLKRQKESAPLPARSRESWKQLESKLKPVNPAQAAAKAATDVCAPPNRTDPMSVDITMGPDFTAVVEMRIGLDAPQLRDFFQAEPTDFQYKLILIETKNGIVENASTVITRNPKVTLRKLQNDVVYHVTVHVTVPNAEYRLTKDAKFVYHQRHSPSPTPEPVAVTPQAVQPPINVGSAMYTLNVQVGEKDYATCAFADGDDFPVVARQFIQDNRLKPVLLEGLLQAMQQLRASGVTIRSVDVSDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4P9</accession>
    <name>A0A061D4P9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767734.1">
        <property type="nucleotide sequence ID" value="XM_012912280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4P9"/>
    <dbReference type="GeneID" id="24564089"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207060"/>
    <dbReference type="OMA" id="ITAHMAK"/>
    <dbReference type="OrthoDB" id="10492335at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600049" evidence="2">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="183" mass="19533" checksum="2D2F338B657572E3" modified="2014-09-03" version="1">MNAFKKVVLLLVGFATVNFASVCVAQAKLDDSTPEEWVKAIDSADDHLKAEVSKLKAEDAYTKDVGLSASKGKIDSFESAVKLFSAARVKVDAAKKALDLKGKTDNTAEVAAVIRESNESIALYFAALKAHIDAIYDISKYKATVVGKVALLKYVSEYDKKIVSGFAAVVSTVALFATALATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D503</accession>
    <name>A0A061D503_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0202840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767313.1">
        <property type="nucleotide sequence ID" value="XM_012911859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D503"/>
    <dbReference type="STRING" id="5866.A0A061D503"/>
    <dbReference type="GeneID" id="24563668"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202840"/>
    <dbReference type="OMA" id="CHTCNIY"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="139"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="386" mass="43545" checksum="3F69BBE30BEE8F1E" modified="2014-09-03" version="1">MSRCCGSRDHVDGVQEGAAPRHAAQRFVDAVKQSVHRFIEDERIIKLVTLLLLYTPVIYFAATAFGWYTTYHGPGVPTVIYIIAALALICFHAVSCMNPGIIPKMADSSDAYDAIRMKRKYSYAPPCIEVAIAGKFLRVKYCHTCNIYRPPRSVHCNVCDVCVHRFDHHCKWLRNCIGGNNYRVFYLFITCTCLENILFAAFSILRIVMVSTNYWDTAAIIHSAVLLSYMLLCGWFIVGLTAYHTYIIGMNKTTNEQLKALYTEYNPWNRGIMRNIADTMFSRAKMQLLCNATLKARPIYDPGRSVPIHLTKGPLVGDQTLKGRRPAFDVTSEEPWERTDHDDSENGQTDEAESCPQPEVVEDLVVGAVVDDAHVHDESCTNVDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5C0</accession>
    <name>A0A061D5C0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0210440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768077.1">
        <property type="nucleotide sequence ID" value="XM_012912623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5C0"/>
    <dbReference type="GeneID" id="24564432"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210440"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="780"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="910" mass="102982" checksum="52CB8BA537BF3217" modified="2014-09-03" version="1">MDDMWVATLACPRHVNGTEYVLHPQPTADHDDTLKTYVIEDGKFRSVPFSSVVVTESPRPYGWKATNESQTDLHIDLMDDDIYAIAAERLVFICGPRDLVLTDALQGQLARLPEIYETDIYTWDSTTSLVGELSKTGKSLGVVFLHRGLNHQLLQGCGSRPSKLFARHNYVTVDPVTGTRSCVVNPISTLRTGFVCEGRIEPNDCMKSLLDKGRVVTAPRPYLYRYFDIHEPWVVARYFNDVALPRFNGECRCIDPETGHVKARMEIRWKTEYVCDIASLIVRNRFKPISGPWCSVMLHPGATLTIKLPKQTDKSAATDKEFEDVDDIEEDAFRVPFSQLPSIHAYETEFKPDTELTLRQIQTIYDINDYDEIVTNKAFTGDVLEVDISQMERGEVKLKYHTGRPLALRSGYNSFLYHWTFLSRNENVLEKIRAVVNVSFAPTYRYNIIGCDRWRPSMFDPANDVGSLAIKDMGNGIGKIAEWLLNVVRGEEQAGIRCGLNEELLPNNCESTGYDLSSNQIAPFPAAVRNATLYPVRGFQVFEMSFQNVPVSHACSCVDVRGYETSRLILKSNRREEYEYTVRREDANQRLLPYLLLPLIEVAYVYGYSNLTSSIMLHNIPQRPIKLQSGTEFFMRCALDDALDNGENNGGATPTWFPYYPGYYHYNVDTTAEGSMLIPMRNEDRIAGTKGGLEFIMLEHNNQYSDVTIKSHGDAILISMDPDHSAYVPMTFVCGKEFLESELLQFNDEDFGDTIAQVLPPLEEYTWNVVQIDVEMTDPYMQGCGITESRDTLFKPETPKIYDAEGKAIGCKIDIQTADEAAFYCPAPYVLDPPNCFDHVYVNGEVMNLSEVSYSLVASRTNHFVTLEFDGRVVGAGEMLRQTPPLECRCVTIKGIVLSTIQIENYYAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5N7</accession>
    <name>A0A061D5N7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768049.1">
        <property type="nucleotide sequence ID" value="XM_012912595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5N7"/>
    <dbReference type="GeneID" id="24564404"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210160"/>
    <dbReference type="OMA" id="CKKYTHD"/>
    <dbReference type="OrthoDB" id="365497at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012768395" evidence="1">
        <location>
            <begin position="16"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="621" mass="69293" checksum="A2372EC85FB50947" modified="2014-09-03" version="1">MKAALVFLLAALAHAQPEMDTSAATIKLQAEKAFEHDIAEYTLKVLSCPSGTGLTITKAEWIATFSGQLDTDENTPVRLDRTSDVRKICRGLNNCILKPIAHLENVVDKIYHFFGVPFSNAKYTLNISGMCQSTARRPTGREMVASIDPSRDLVMGCDEGEVINLSFVRGAGLFHTWQYRHNYCNRSFMENAFYICQNQRSCTVDKSLYISDTVCNYQVIDAQYFCRPSYHNAYVDVIRKNGNDEIILTAEEDSFVTVKAPAESLLSVKSAVWDVVGKELEEDDTRRNRLDLLQFFCEGRSSCTFSPRRTSNGLLDLHLGGITSDNQKPFVFKAKFGIVKGTQNAADSNIKTIPCKHGQTVAMTCPSDRYIRVVSALWGGEVTDTASQPTNIFWEEKTVDGKLYRTTEIGAFLDKQVFNKSEFTFDPFAVVKEKRLLPNIEGIRENDHSLTVKYTCVDLASKPSVSDLGLVDIKSLTSDYDEEYSLSKEKVIPFGFKKNNQLIVMIEIQGTSEVQVGKFLSIQLPGGAEGNYVATLPQNNAAAEHKVEQPCDNAVINVLFAENKTIHVTTNLYRGTELVATLVDDLTSASEIKFEEEVKDIVHASGNVLGMRVFYKDFTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5W1</accession>
    <name>A0A061D5W1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768134.1">
        <property type="nucleotide sequence ID" value="XM_012912680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5W1"/>
    <dbReference type="GeneID" id="24564489"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210960"/>
    <dbReference type="OrthoDB" id="366461at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="475" mass="53067" checksum="D15E9B59AD14EF98" modified="2014-09-03" version="1">MELKRKSHICEGVEAAVAEAIRRELRNHDDIARLVWWASAFSRADLTGAARANRPWMADRRLAAQLVAANLEAAVPLIDSEALTLHQRGTVTKGVAVLMFAQCAILLKDARHACKKAYSNINSNSRGAPAAATLPRSKTRGRHVASAATPEHAHEPLWNRSVHRVLTDKKLRLECLDTRMKTPNAHDGFAYNKIIMGVGIYSQFEFDEQNNIRKQLTQVVKWNAPAGAKSPAAGLLGTDDVMRTAPALCNAPSKLPRQMTYLHDLDDAVGEQERVQLRRVKRAALEAFDDCVVVAPELLLPKRRSHHTKTAHTASAAHAPQCCPEPRRPSPGQTCTWFDIRETLLHECELKYKMFLVMSVEQECPQQRPVTDRGPRTRRGVTRQSECLVDPPHTRLNPLIRLRVLRREQAEVVPAAVHQGACRERRALRAVDVCPSRVCLMRSQQSPRVLPSGTRRGALLLPRGARQRRSRPPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Y9</accession>
    <name>A0A061D5Y9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767618.1">
        <property type="nucleotide sequence ID" value="XM_012912164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Y9"/>
    <dbReference type="GeneID" id="24563973"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205900"/>
    <dbReference type="OMA" id="ARYIDFK"/>
    <dbReference type="OrthoDB" id="366161at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="345" mass="38169" checksum="6D71C0FFEE5BF805" modified="2014-09-03" version="1">MLIAQLFQNPGLLRHLPFLCSRRLFSASPIDVFSFGYSGRTVTFEFRGVPSLCKKRLGTTDYVSNKKIVEAAVSAVPTCDLVALGVGSPELDVIRRYLVFEESKQSKNASVRKFKGARHLLNGYRQHIHVVTGADAAGIKVVAIGRSKRSEAISFGEAATGHKFELLRLLSLYLRKGDVLKVPEIREDFKLAAPAIYQAVVTEGAVYCLCRLHESIYNIDTITLSRRRNVKVLVVVDDWLVRELAHMVRRKLPQLIGENAPPARETLENIDNRSSAGWRRFLLRFVVLPLIVVVGTVGYKLCVLLGAPFMDCVARLSGRTALGISASPEMQLGSSKAQSSNTSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D603</accession>
    <name>A0A061D603_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767633.1">
        <property type="nucleotide sequence ID" value="XM_012912179.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D603"/>
    <dbReference type="GeneID" id="24563988"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206050"/>
    <dbReference type="OMA" id="MLDEMCD"/>
    <dbReference type="OrthoDB" id="345453at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020035">
        <property type="term" value="P:adhesion of symbiont to microvasculature"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005553">
        <property type="entry name" value="CLAG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03805">
        <property type="entry name" value="CLAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600634" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1351" mass="151881" checksum="60B2528597606342" modified="2014-09-03" version="1">MTRSMRGCVRLIAAAIYLAIHCDVYAYRDVKGGGIGANGAVSVPVGAADYAKLKFLDAISGTKSEEETKSAEWIETPEGMIAAPKGGDQENNQTEVAPEGDNVQADSLEADLSAQPLRDHAAVGSGENIAVLERSVGIKGFMEPFINSLSTDLRYMLLKQTGTNFLHVYRKYALKLETLEAPVYRKMVKLVEEKADAIGFVDFSEKRRNNLMPEVNQEAMKVAGITSLLQIGTEVAFPKLKKAAKSKKENNVTKVAEVKEQPKTVKEEPKTVNEPQPLPVFEPWRKNTEVLEAMLIKVLFLLGGDKHTLDVSDRLRNMARALGFRKKEESEKKAEKSSTAMNLGMELFAACGNNPFLLGHLATNMLAYTQYKLFFDGDQGRPFYTWLDLVKSGNLDMLDRMCGTIRGPKYKRDSNGAVTVNKNRKRKDDPQLNADGVFLCNLLEVLLVSIDASIDAMGQLLSQYGVPYEHSVGAIANGRRMQAFVCSDPRESAIVVRCDFMSSTLNSSKIFEGKSKYEGEELWQRLQDAFDLFKLLSDVSLDGEIPTTWLRMISDPRKYATVFEYAVKFDNRMFAGKKKSWMSEYKKVEDKFISSNYSGNIDLNTAMSLLKSGGQKAKTGTDDSLKRALLYMSASGIKTWVSGNLEGLQKNFGFSPSVLLAGNLAPYFRQVAQTTSGGLSHIFLYHMLTSPTPAYHFQSDLSSFRGGNLLYNIVESSNMFIPASLKRGIKWLLKGGLAKEFRREKAKHTLLQLLPVELLRKAVGAITFVTHSLADMQINQNAPIWGRGMMSAKQREHKHFVNGGYVNHVDTIIKEWSDEGYTDAIAKKVQHGDDLNKEDLKNADMHHIAHSESLKWDKYLNARILEGYNAFLDMPSMKVLEGKHSLVYEIVKDTRDNLEQNLGDTVFFGRVVPPPVYNNKWKRFLQRASKVKKIVFHRSLQNVEHAVWFGIKLNYKHVVEVVEELNKISNLISSTESYNLQEAFGHIIDDAVAVVANEEFRRPSGTQENFGIPSVNPLYTRMTPDERKVEFQQGMCGQHCGAIWRALLAFTMNTMRSPASIKTFEKSLSQNNTLQDMEKPEFVNSMRFILKGDAMLHMYDSMLPKKMKNELRAIKYGKAFYFANIMKVASNVLGILGYRYTSNMLRIQAPYFGNFVVQWDREREKSRSKAIFAYLSIGTMAAYSVMQCAEITQHAADVGQGPVESCFMLIKPPRMHCLLQPAETIVKTALSIGVQDALSVTVMAVIGPYFFLPMAAYASWQILKHHFKVIHRLDIALSNTFKRMWSKISASSIGKKLTAWFKKRREHRKDIESKGLLAMKNQQPTNEESGAVAVADEMLKSDDYFSYTSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D662</accession>
    <name>A0A061D662_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RBM22 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0300910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768372.1">
        <property type="nucleotide sequence ID" value="XM_012912918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D662"/>
    <dbReference type="STRING" id="5866.A0A061D662"/>
    <dbReference type="GeneID" id="24564727"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300910"/>
    <dbReference type="OMA" id="PYYRRNK"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="28157" checksum="A2D7836D39E2F79F" modified="2014-09-03" version="1">MDVSGFGIARDVRKQTSESSEFPTLCETCLGPNPLIRMLKERCAKECKICERPFTMFRWKPGPKARYKQTIICQNCSKIKNVCQTCLFDLEYGLPVQVRDEFLKNGIELAEAKANLNHQLGKLENGTLELPRSENNPMLEKLARVAPYYRRNKPRVCTFWLRNACNRGEECPYSHDNDDLHYHDGALAKQNIKERFHGKNDPVAAKILKRIEDSKKSSSEEEPNTQVKDGIYPSMLPHEAQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D665</accession>
    <name>A0A061D665_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768234.1">
        <property type="nucleotide sequence ID" value="XM_012912780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D665"/>
    <dbReference type="GeneID" id="24564589"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211900"/>
    <dbReference type="OMA" id="EATCANT"/>
    <dbReference type="OrthoDB" id="367099at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596009" evidence="2">
        <location>
            <begin position="26"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="293" mass="31705" checksum="521E7894F23A53EE" modified="2014-09-03" version="1">MKANMTAIFGIFAFVFVSIVPQVQAAEDDELANALTWEKIMTKLYGYYGPIPVPGVDYNMVQQPLPPDHPRNRRNMRGRPRARPNDQVAVPVAPKPTKPVAVVEKPESDKVVEPVEPTLDEKDSVVEEVTPDTEETDAGESAAEEEQSSVSEGDEDDDDDDDDDDDDDDDDDDDDDDDDEEETAESGLEEQDVAVEDNTNADGVDDVVEATCANTVSAMNEAEVEAEAEVEAEAEVEAEAEAEVEAEVEAEVEAEAEAEAEAEAEAEAEAEEVSAPVEPTPAKKGGFFSKFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6D0</accession>
    <name>A0A061D6D0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0107870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766675.1">
        <property type="nucleotide sequence ID" value="XM_012911221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6D0"/>
    <dbReference type="STRING" id="5866.A0A061D6D0"/>
    <dbReference type="GeneID" id="24563030"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107870"/>
    <dbReference type="OMA" id="GIHHCHR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="352" mass="39904" checksum="8AD6E2E842BD354B" modified="2014-09-03" version="1">MESKGSDDGPGDLEKRFKPLGKHLGEGTYGTVSMFLDTLTGKNVAIKKVKNIEWKGERQVVGMVGIHFTTLRELKVMRELHHPNLMDVVAVFVSQGFINIVMNLMAGDLKKVIDSRVRLTVPQQKCIMWQLLKGLEELHANCFAHRDLSPANVFITDGGVLKIADFGLARRCVYSPMVPPTTKRINPAELDKYCVREKMTYRVVTLWYRSPELLLGAEAYHFACDLWSVGCIFAEVLDHKPLFPGTNEIDQIGRIYKLLGTPSETNWPNAMKLKLYTPFSVEQPKQLDTVIKGHTPEALDLLQRLLKLDPNERITAKEVRRHVQALAHEYFTTPPLMCKPDQLPFDFVAGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6D3</accession>
    <name>A0A061D6D3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 associated polypeptide p18 (SAP18), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768432.1">
        <property type="nucleotide sequence ID" value="XM_012912978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6D3"/>
    <dbReference type="STRING" id="5866.A0A061D6D3"/>
    <dbReference type="GeneID" id="24564787"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301500"/>
    <dbReference type="OMA" id="HTSQRTH"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="383" mass="44622" checksum="748FF8423E4724B2" modified="2014-09-03" version="1">MRSISSSSRSMSVSRSFSNDVKRSSSHYSKNRTEEPRQYARSSTESSPELRTRRRQSDSRGSSSRSRSYSKPRRRYGRDISESRSRSRSIQRSRIRSRSPVRSRRKRVSRSVSSYSHSSSYSSRSRSRPRRQLSKSRTRRGRDHRKSRSISVDSRSNYRRRSSTSTSYSPPRRRGRDQRAVDSRDNRRVARAPLKPYRSRLDAVDRDRTRMRQLVTRGREAPIRPLRPYARRVGQKTRQELQKVASVDRKVHSPFLLRIYAFMDEAAGKPCDPDEDHESLQRRIESSDSIEKLELYIWADNTLRDLVNLVKDLCEASRHKEGTWTFHRNNAARDTLGAIHSYKLHRSTDTITLRSVGFRVGDSLLLSFSGVAPPPEENTQMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6D6</accession>
    <name>A0A061D6D6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0300230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768304.1">
        <property type="nucleotide sequence ID" value="XM_012912850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6D6"/>
    <dbReference type="STRING" id="5866.A0A061D6D6"/>
    <dbReference type="GeneID" id="24564659"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300230"/>
    <dbReference type="OMA" id="TICNSES"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="6">
        <location>
            <begin position="72"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="7">
        <location>
            <begin position="294"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="358" mass="40524" checksum="E1E213F930B42097" modified="2014-09-03" version="1">MDNSDLESQLFSAVAANAAKTDESSGNHNKLDEKVIDLLGKGDVVGFSKIVSCIPETKVKLPPHLLYDMLIWKSWLINGQHLCFYGAGSKRQLIKVFVEFALRDGTCLTVDAYRVKGSTGEDFWQLLKRELLSKKTTMTVPECKRVFKRVLTHDVFEQAVLKRIATVRKPFYIIVYNLDNLATIGASKLIRTLIRLSNVRVVGTMDNLRSSMVVSSFDQILNKYKLIRLNTGMDYRSELAALWDRSPPRIIARDETQKSATEMQAIIGALSVNHRQLFSLIAQMQLDGLKSRTRFDGVEKYGLLREPRAITICNSESKLDALLTEFITHNLIEQSRGRGGRLYLTIPFSMWVVLPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6I9</accession>
    <name>A0A061D6I9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0108520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766740.1">
        <property type="nucleotide sequence ID" value="XM_012911286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6I9"/>
    <dbReference type="GeneID" id="24563095"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108520"/>
    <dbReference type="OMA" id="LPENMWC"/>
    <dbReference type="OrthoDB" id="5334309at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="Filamin" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1244" mass="137927" checksum="C3AF8D04A3F2752A" modified="2014-09-03" version="1">MTGCSVRQADGSAAAHGRHVPGVDHVIAQPSTTYVDGDGVYGGECGKWLKFVVRKTESITRGVLRLNLEYADDAFLRASVFLTSNHDERDLLSNVPACRNNTLVNNSVADALEHIFSWDVCVVDRCTFNVRYRVTRKGTYSLHVKLDGNPLPGSPFRIYISEGAPSTAACRVYGRNVGTCCAIPYVPEIMNAIFPNASPCAATSRDDARTKRNAARSASDDAPTKGSSCKSDFSPIDNFNRNTCGYFSNRSAVSIGGWLADNSTPDDIVIPNHSAPDAFRPGGTSCADNSNRSENAISYAKQSVADPDFRDVERGLPAAGNAVGRGVGCTRRSISSDGSLSVNLSGDSAATAHSHIKESPRTPSFNPYQATNRNCTADAGGRGNVYSARSFGPPRASMNSSEADMLPMEFTLGADTSAVPEGRTTLANEPGAVGSCTRSSAMTSALWDGLDDRRSSDATRKRRQHALQQLERRGLLNEIEIRLADAHGNAVTHALPYVQAWGENYARVVSVDNRPNGVVIVKYVVVVPRDGLESLKTAQSHESDSVMPHALRVGGVPCKIHVEINGKPVFGSPFHPQVGNVNEVEHYFETTVGTTECLMQTFTELVRNNDFDGCAELYSMVETDEVKDKLTGILLTRLSELEKTNIAATSNIRLVESLKLQSLGRLLELVQSQYKKMLTYKTSSIVDCIRELKSFENIAADQKGNKAASDQKGEAAKRFNNLGDVILNYRLIGDELRKLHRYELADKFDQINNQMCDEIDLGMWTSIIGHKESQVQKLRAEVESAADRLTRFKDDVEERYKSFTRKDLADFRGTPGFAFDHGTQTEAPELLTTRLSSLVRGRCVPTTAHNEVDKIVEAYWRKCNNYDIQTTVAKVLKSSVRLKNSISELFMYYSTAHPRESGGTMLGVSRASMELFVLQLRLNNYLTANVQKLDWLFERFSLELPSGQADGSTPPQRAIPEHMWCAYLREIGYLNLLYTIAESGDREILRDHQHPSRLVAFHHLCKEHLIPLYEMLFTTKPEFQKCLKFTDSKVDNGSQRVNKSAKKAATPSEQYFRSRQDILGYFNVHALEHVLNVLDIDVLQRVFKHYSRISMFGRQQVARDWFDEKTATISTATFVVFARDFQIIPGHMDGESVHTIARGVALRGTGGANKLVLRDFVSAVSRTLARVVLASCLAKHDAYERIRDSLTETMETAPRCVQSKESVKRDIMVLLQLLGICNLQFVRYTIDAIYGSEAVEQMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6J9</accession>
    <name>A0A061D6J9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768369.1">
        <property type="nucleotide sequence ID" value="XM_012912915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6J9"/>
    <dbReference type="STRING" id="5866.A0A061D6J9"/>
    <dbReference type="GeneID" id="24564724"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300880"/>
    <dbReference type="OMA" id="WKLIQHE"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="198" mass="21921" checksum="BC8AC3AB27F92A7D" modified="2014-09-03" version="1">MADDAETALSTYAGTFSNIVRKLHPTSATGDVTQEETNLSLINALAPGDALSTEPVAEKARTQGELRKEVEQKWNPLTEREPTVQDEREWRAIQLRGFMDPKKFYKGSKSGKMESLPRRYQVGILTGSSGVKAGSGEESQAVGAANSRRSRGVSVLSETLASDQTWTKKKYREIQAEKTSGSKGWYKRQRKKLKAVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6N4</accession>
    <name>A0A061D6N4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S19, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768532.1">
        <property type="nucleotide sequence ID" value="XM_012913078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6N4"/>
    <dbReference type="STRING" id="5866.A0A061D6N4"/>
    <dbReference type="GeneID" id="24564887"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302500"/>
    <dbReference type="OMA" id="WAPFVKT"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="171" mass="19722" checksum="5050CAD596DC30D2" modified="2014-09-03" version="1">MELALDKQMLRVGRLDADVPYRRFNTSLKDCNPDVFIAAFAQQMELKNYVDPPKWTDYAKTSVAKELAPQNPKWFYIRSAAILRHLYFHPDEGIGRLRHVYASRKRRGCAPNHTCPASGKIIRTIVQQLEANGFLEKSKDNKGRRLSRRGCNIVNEFARHLTRSLMEQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6P8</accession>
    <name>A0A061D6P8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766805.1">
        <property type="nucleotide sequence ID" value="XM_012911351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6P8"/>
    <dbReference type="GeneID" id="24563160"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109170"/>
    <dbReference type="OMA" id="MPLCTID"/>
    <dbReference type="OrthoDB" id="364825at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="269" mass="30218" checksum="592FC1CC9A1330ED" modified="2014-09-03" version="1">MPLCTIDEFEKEVLDIGANASDAYEESDAPFAADADDDEDLGVFVFYQGDVDGVCALFILEHHKRLSHGLKLTSYPVHCEADIYSYIKKNLSIITTYPDVQHEAYLRVVLLGVHGWDPELLYAIKVHFSQKLPESRRSELKICIVPASRPLTFFNVSFDADWYFFVGNEEEVALEQSIQERELVGGIYMSTSVASLIASITKTTHESSRAAIMYASAVATISRMEHSCSLDTNVNTQITRLFQEISMLDGGPYVQYDSERTPFPLISFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6S4</accession>
    <name>A0A061D6S4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766825.1">
        <property type="nucleotide sequence ID" value="XM_012911371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6S4"/>
    <dbReference type="GeneID" id="24563180"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109370"/>
    <dbReference type="OMA" id="HPNEGTI"/>
    <dbReference type="OrthoDB" id="366352at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600650" evidence="1">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="435" mass="49353" checksum="8F7103BD553D6685" modified="2014-09-03" version="1">MSAPVKLLWFWFALFSGQAFGGRLLNLLEDPLPNHVQVHRGIFDDNGLYRMFVPESYSEKWFYYGDIMVPIVHSCRQLTICVEEYRSTTTFLEVITVCLDDINAIRRYTRLYEVRNNILTCQSLAKLQHVVKGSILLTLDLSPGASLHPYIVKKVNTSDHVIQYQVSPASIEGRKKSSRKKINYAILFTHDSSSSQDRGYPTSLVVFHAKSVVLNILTGYLFLKRFVPNQFYIYTVHPNEGTIKLVTPSIPSENLFVNPAMSPFSGTPQVTAVTINVTSVENPSSNVLVIYNVPKGDWLYSRHEVLIFSHVWRVACYVKDRMTDIPIFVSPEDVMVKHVETYNNLKDNKFFVVIKTVKRTPGGFITSDKLFQRVENEGMIGYIPHFTHKKLLYEMMLKEVYDTPAAPAGEARGALRYEMDTSGASLPPATPSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Z0</accession>
    <name>A0A061D6Z0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proliferation-associated protein 2g4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0209160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767948.1">
        <property type="nucleotide sequence ID" value="XM_012912494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Z0"/>
    <dbReference type="STRING" id="5866.A0A061D6Z0"/>
    <dbReference type="GeneID" id="24564303"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209160"/>
    <dbReference type="OMA" id="SRMFYSE"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="30"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="394" mass="42688" checksum="13DD8B5D57A889DB" modified="2014-09-03" version="1">MASTGASNTGADVKVEGNENDLSNSDIVTKYRTASTIANAALQKVIAAIKTGASVKSLCKLGDDTLLQETAKIYNKKENGRKIEKGIAFPTCIAINELCDYFSPVDDGACVADGDMVKITLGCHVDGYVGIVSHTVFNGESVTGKAANVLAAAWTCCEAALREMKVGNSSQKVTKVIEQVASEFKCTPLMGYVNHEMKRHVLDGSRYFPSSTRIEEKSEPFTFALNEAYALNVLVSTGEGKPKATEHKTTVYRMDVQNRYTLKTTLGRAFISQVNSRFPVFPFHISSFEDERVLKVGLPEAVRHKLVMPYVVETEKAGELVAHFRFVVLLLAGGTKKISGVPFAQQAICSPEHSVQDEALKKLLSMALNPKVRKPKAAQDGEDAAEKEADKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7D9</accession>
    <name>A0A061D7D9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0305290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768812.1">
        <property type="nucleotide sequence ID" value="XM_012913358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7D9"/>
    <dbReference type="STRING" id="5866.A0A061D7D9"/>
    <dbReference type="GeneID" id="24565167"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305290"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="167" mass="19125" checksum="A7D256FBCE031FF8" modified="2014-09-03" version="1">MCRHALTYAQRRRLLLDLRKLQQELPESVCASPTDGDLFNWQAVILGPRDSFYITLAGIFTLSLKFPTDYPHKPPTVKFTTRIYHPNIYQDGSICLDILDREWSPVFDICGILTSIQSLLTDPNNRSPANKEAAVLYTEHRAEYIRKVKEAVLESIEAAETQIENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7M6</accession>
    <name>A0A061D7M6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768178.1">
        <property type="nucleotide sequence ID" value="XM_012912724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7M6"/>
    <dbReference type="GeneID" id="24564533"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211390"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="307" mass="33754" checksum="0178ED4877CDD178" modified="2014-09-03" version="1">MTNKKISISYDPLGKHKMAEVKNNKCECKPTRCGKGDEPCANPQCIECKYGCDADCKGCEKNCKDGKPCKCCTPVCGCPTNCYGDDKKSKCKGQNSCERCKVKCKDSDKCICHRCSCGKQCTGVICSCCSWCDPKNCSGKKCDGYVIGRCEGNGPCKGHVKYDNDGNDNYGAVLNRNDTNRIPCDGKPHPGKKCTGNNCNWISADDIKDGCCLKFCTYCGDLCGQDKFRRCCYIATPVVITVLAFLIFRFMLPEKFHAITTKIRAAFPSPPRHPGRSLSNLVGDRLPEEMNVDRYAAFRPKAFAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N6</accession>
    <name>A0A061D7N6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-dependent metalloprotease FtsH family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0200660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767095.1">
        <property type="nucleotide sequence ID" value="XM_012911641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7N6"/>
    <dbReference type="STRING" id="5866.A0A061D7N6"/>
    <dbReference type="MEROPS" id="M41.A21"/>
    <dbReference type="GeneID" id="24563450"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200660"/>
    <dbReference type="OMA" id="KYDSDPM"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000352">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 7, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="249"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="688" mass="75469" checksum="B06089A059E83C92" modified="2014-09-03" version="1">MLGSTANLACRSVRAAVAARQPAGPFSLVFVERFTTHRMYRLRRAVADDLASGRLDEHTLREANRVDPRITVNAVEARHSNGFPNDEGVLREYLKALTLTNAIDSRSLKDLVRALPSRSTPAADADSPPDPRVLEQLRHVFDRNEMYLKSDAKHPVHVVVTPAASSVFTRALKALVSVGSIAFCFGTLYILTSQNIQRGLKHSFKVVDPDDLDTTFADVKGCDEVKAELDEVVAYLQNPERFDRLGARLPKGVLLAGPPGTGKTLMARAIAGEAGVPFIQASGSEFEEMFVGVGARRIRELFKLAKSVAPCIVFIDELDAVGSRRSATDHNSVRMTLNQLLVELDGFDKREGIVVLCATNFPESLDPALVRPGRLDKTIHIPLPDYKGRYDILKLYSKKISVAPDVDLSTIAKRTVGMTGADIFNILNMAALRCSLQGLAAVTSSAIEEAFDRVVVGLKGKPLTNEREKKATAYHEGGHTLVSLHTPEATQVHKATIAPRGRTLGVTWKIPEEKSDTRMSELRAEIAVLMGGMAAEEVIYGKDNVSTGCQSDLQKATEIARTMVLNFGVGLENVSGPMFLDAKGYSDLSEEHRKRVDAAVQQVLDGGYQHACRVIRGNLVQLHNLSDALVQYETLNADEIHHAVQGEMREIDDARQAQQVELRAQVKRYSQTQGGKDLIPEPQHSYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R5</accession>
    <name>A0A061D7R5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767130.1">
        <property type="nucleotide sequence ID" value="XM_012911676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7R5"/>
    <dbReference type="GeneID" id="24563485"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201010"/>
    <dbReference type="OrthoDB" id="365655at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="618"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="777" mass="84516" checksum="43131D846D331E5D" modified="2014-09-03" version="1">MRPSSTSSGTGRMYQVLFGQQSHLYYLCLSVNPYRSIAVLDHNLRPIRRIDVKDVLSFQRRVLSNDPSHHSGSVTHSDVSLCRHCLQLVQVFELQLSSDKGGWLRFGLPTTEECDQLCSSVQLHFGVPVYNYGSLSTNFRASLGPKAAACSNTVDKGPNSVCKSYRLVRDDFYASAAGDFLTQLGITCGDNDQGLGDPPAEFSTDYPVIMEGPLEAASYVSFRSMRKPQMHPFSVYRAEWYLSTHRGDPGEFYPAASCSNDIFYLNDWTIGRYVQLRVYKAVGTGVNRKFVFTTATRGPVRFSNVLAHNILLNVSKDNEAHNVLICAKQFRAIAAHLKKLPFAPTGGTDNFDRRLSTKLSLMQIKSSARSLHLPGDSVEELSGENVDNKGIRDSVTASMETAIQPAVTYESTGSFGSYADDNSDFLGELEGNAGTATPRSGAPRPTEDPELFHTKSLLSADSATVLCDSDGARDSAASASRDASDAAQPGAEVGVTLATWHQPVTQETGKAEDRPAKKQQPATADSAPTAPKAKPPPKVAKATPPPKAAAGGAAKPPPEAPRMGRVRGFFKNIFGKARPDKGRNVPAKAVAKSVSPVTASKAEPLVKAKQQGLLPPGPNAAAGPATPGPTKPDEDFVEVQLQCRCAGLYLWNDEVELELKWTRIDVQDCYEPSQQPEPYPDPASCLEVTLAYKCKGDSEQRLLPLTIRLSSPQQRCTLYHAMLFNKYRGPFYSIDQGERDLQRGLYSDVKDAYAKICKHVARRLARVSSASPPTCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T5</accession>
    <name>A0A061D7T5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c oxidase subunit Vb, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0101040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765961.1">
        <property type="nucleotide sequence ID" value="XM_012910507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7T5"/>
    <dbReference type="STRING" id="5866.A0A061D7T5"/>
    <dbReference type="GeneID" id="24562316"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101040"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="338" mass="38795" checksum="64CB44717BC3577B" modified="2014-09-03" version="1">MLHSPFVGGEIEQIIRVATNRAFRETAKAIFVTRQPSFGTWRKAESPHFRAYAREEWSYPQITHMTPNMAYRIVASLSRPVRPTFAVARSDFLRNNARGYVHFSRTQTHDFELPIDTMPKDIDALMKTDPKMMDYFGSYWYWRIRGESTLMDADSLPKKSYKQLAVDLGMQVVNEPSEHMLGLLELYEYLKTSPFVGPFGTIKNPVLVPSVLTERVVGCTGGAGEHEHVPLWFRCREGFLYRCGECDQIFMLVRVLYSLPDGEDPFPVDPDIDDVFNKDVLAKGHLKWNSGEYLRWPVGNATYKQLFLQGKWGNPVPEITASKDADADPNRLSEFRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z5</accession>
    <name>A0A061D7Z5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ISP3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0101490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766006.1">
        <property type="nucleotide sequence ID" value="XM_012910552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z5"/>
    <dbReference type="GeneID" id="24562361"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101490"/>
    <dbReference type="OMA" id="HRNSCES"/>
    <dbReference type="OrthoDB" id="364474at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041296">
        <property type="entry name" value="ISP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18045">
        <property type="entry name" value="ISP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISP3 C-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="174" mass="19473" checksum="503FC7CEA61964BF" modified="2014-09-03" version="1">MGNQPSSAQGDGKYDPNALFARDESLQPEEETYFMNHMVNGCETHIVFADGSSLPCSVIYDLAEDCLHLQVDDKRRVIALSDVEEILGVDNVEGLSNVDKALIIDAHIVAFRLSSTKKAILLRFNDLKESKGFYHFLKEIIQENAEKAPNPELLGADETAEEEEPNEWSQTIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D800</accession>
    <name>A0A061D800_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0101590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766016.1">
        <property type="nucleotide sequence ID" value="XM_012910562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D800"/>
    <dbReference type="GeneID" id="24562371"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101590"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595883" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="822"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="952" mass="106732" checksum="0304087B41EC0B14" modified="2014-09-03" version="1">MEVFNTRQYILTFCAILLHYVTSTNALICDFGSAYGNVSNNALVMCHMDLDKHKTATVVCPRLVNGVEYVVHPQPTSEDNAHVNTYVGGEGTFTSMPFSDVVRSESGHNFVWLESTRSLTIMRFNKPNDELVAITEHSSTFICGPRDLVLSDELQRHLESLNGARSLKLPWASSTPLTQEIAKIGKGLGIFVLYRGRGHLPLQGCGSRPSRLFAPDNEVTVDSETGMRSCVAEAMSKSPIGFVCEGRIEPEDCMKSLIDDKGKVVTAPRPRPYWDFGYYRPWVVAKYFSDVALTPFRGECRCVDPETGDIKAKIQIRQNSEHVCDISRMIVRNRSQPIRGPWCSVVLHPGSTLTIRFPTVDGAADYDNSMLRTSSRQTSINEYETEFLPKDLKTVRQINTYRGVNVYDEVSYQEVLVGDAIELDVSQMHRGEVTLKYHVDKPLTLRSGFNSFLYHWTLKSKNENLAKKIQATVNVSFALTHEHEIFGCDSRQTKLFNEDISRQHCSTKRMGNGIGDTYECLLHNKAHIHQAGIYCRPEERLLPGNCQYTGYDLHSNRIMSFPETVRSITPQPITGFQVLNMDIQNIPVSYACVCVNEHGYETSRLTVESSCEESRTFTVRRINGLQKILPYVSLRLNIGLILEGHRSGMFITLQHVSKKTIKLHVGTKLLLRCALDTALQNVSNDTISPTAWLPKLHGKYHYNAIVTFRGLELITRSHNDVIAGSHGGFSVLFNDDHSSAHQALILELRRNAILISKDPVHKKNVPMRFVCGKAPQLSDSSAVSDYALHSDASVQSTSNITDVAGKYTWNIVKVNVETTDPYIQGCGVTYELDELFKPETPKLYDSYRQRKSGCKIDIQAAGEAAFYCPAPYVLDPPNCFYQVSVNGEVKNLSNISKSLVPSRTNHFVTLKFDSARIGPGETLRQSPPLECRCVTTKGIVLSTIQIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8E6</accession>
    <name>A0A061D8E6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768433.1">
        <property type="nucleotide sequence ID" value="XM_012912979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8E6"/>
    <dbReference type="GeneID" id="24564788"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301510"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="88" mass="9806" checksum="B43BCF50D4D66024" modified="2014-09-03" version="1">MSLIVKLEKRCLLRSLEALTVATARAQHDIGISDAPRFYGKFSVHEQYKAIADSFALNEIQMSASRARQATHNPRHGEDKGLVRATDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F3</accession>
    <name>A0A061D8F3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769167.1">
        <property type="nucleotide sequence ID" value="XM_012913713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8F3"/>
    <dbReference type="STRING" id="5866.A0A061D8F3"/>
    <dbReference type="GeneID" id="24565522"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308840"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="103586" checksum="0A30EF9479FC9CF7" modified="2014-09-03" version="1">MTTIPFRTLKECLEFLQWLINDKRNDVRTRLAGRLKRLIEGKYKSVSAQQIENALSTFLNHVSHFHKKLCRTAGQSKIKSITGRDALEALLQCIPKLLSVIYFLQYHVDTRFAKVGGGDWAGQNVGMVAMYARFPPAVAARYASSASKIDTYLITTVDGNQYGVIPGGFAAGELKEVARDGYNQGSLMVPDLVNIFDKEHIPNNLFRDVFVTSVVFKNSADEISNVANALRLVQDFCGIFGNSKNEQEFKMHLEDRGKCINWEELKQQCATLKTSLGNIFTLNRFSFTGYGRTYEFLDKTIDKRMAQWLKNNLETIRSKLIRLRSQTDFNKFVTTNLIPYGFTFNGTNFNTKMKPKIVMQQWDAIIGELKQANEGLQKLRQILVGSMCPQNKQDKDEDDGDEDVESEDEFGDDDDDDDEVYVDEDLDDEDAVRVSKTVELPPTKVPEIPKKPVTEKQSEGTSNQGKKAEGAQNQGKKAEEGQGKAGGQSDGNVSSSPDNDDTSLQPAVILQDAATQPSSVTSQDPQSSGDPVSSSGPGPVDQRSASEPAHESVHEASKRPVGDTAAPTGTPSGSGGGGTPVGGVEQDPAMVEKNSPTCSGDTIASIDMSGKHFCRTKPTTSYRKLLSDDAHNAIKHAYEKTLLKNVHDEHNMKNHNHRIMQSQNPTTPPNRPSRPAAWPSRQIPFSPQPPSVSPVNQRPQHVPQERYSRDGDDIVLDGKAIEDPSYQQREKLRRRNAAEERKRLWDSESKQEAEKLRQQMENLLRDETLLTETLKQQPTQPNYAEASALQEHIFKNRLSHKSHVTGHKISKQISTYPKPFPQDHKFRSILNRASLPSNRSVGNIRTRGIRPITGKVAHYPEITGTIINSPPVGNAQVKLNNGRVQGPDLIPQTNLSSQSAIIPGVYLDPIPLPSDTALKLHRQIETQKISHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8N9</accession>
    <name>A0A061D8N9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0308020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769084.1">
        <property type="nucleotide sequence ID" value="XM_012913630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8N9"/>
    <dbReference type="STRING" id="5866.A0A061D8N9"/>
    <dbReference type="GeneID" id="24565439"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308020"/>
    <dbReference type="OMA" id="FYAGDEC"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051305">
        <property type="entry name" value="tRNA_2-thiouridylase_MnmA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43052">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43052:SF1">
        <property type="entry name" value="TRNA-5-TAURINOMETHYLURIDINE 2-SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600700" description="tRNA-5-taurinomethyluridine 2-sulfurtransferase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-S metabolism associated" evidence="13">
        <location>
            <begin position="195"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="15">
        <location>
            <begin position="536"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="14">
        <location>
            <begin position="623"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR96898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="710" mass="77972" checksum="E99789F6E39EA9AF" modified="2014-09-03" version="1">MFVAVVAFAALYIFPVCLSVSPSRLHIGVLGATEVGNRRRAAHNHAHRNIKSQFAPLSSLQRCDGATVTGVRDHCAFLANSGAFCGKTIIRRAIDAYGDEGCLVEDPRDVGVDAPSTESIASTRERIKSLSEQLTGASDHRERVQILATHGASLFKGAPEPSVLREPPLSLSESKRFRMPDSGQVSSTSRNYILFPPPCEVDYNLVPGCVSSIYVAVYVDNHGVVHVDGTSDSLITKATLALILDSVELRHSTEVLGMQARDVGHESTLAGLGFMKRDGVGTILNHIKSEVRSQSDRLKIVNKPQRRISKRSAKRVAALLSGGVDSSVALWLLKSRGYDVEAFYLKVWGVEKAEDTGNCEWATDVDHAMNVCSTLDVPLHILPFQDLYHEQVLRPYVEGTRLGETPNPDICCNEFIKFGAFADYATRWGFSHVASGHYASVVEDVSKIDHPSCGPDATPKSCGERITRLQLCKDLKKDQTYFLSRLTQRQLQQVIFPLCRLLKVEVRAIARTLGFTNHARKDSVGLCFLGKVDVHSFLAERLGQMPGPIVDCDSGECIGEHPGLYHFTVGQREGIAEYLSSVRETHRARYVVRKDVATNTLYVTSSYHCGRYVTEGGVRRRFEISDLTWTVPDYSRHITCEGVGAPILALKLRHSPSFSRGVIEFDDPKNPTRASVNLYRADVGVASGQYAAFYAGDECIGAGKMVASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S5</accession>
    <name>A0A061D8S5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768543.1">
        <property type="nucleotide sequence ID" value="XM_012913089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8S5"/>
    <dbReference type="GeneID" id="24564898"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302610"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="13767" checksum="24E91A5718999211" modified="2014-09-03" version="1">MLHNLKWLKGKINKTQDGDAQPNDKTGASQRSENIKSETKSDDNASSPDPAIQDEATPTPEQNQPKEPNPTDVKQPTPSPVATDLQTIAVGDVTDALCGLPGNKVCGKGAMVVQIMRVSNATSAYLLTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D928</accession>
    <name>A0A061D928_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0205570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767585.1">
        <property type="nucleotide sequence ID" value="XM_012912131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D928"/>
    <dbReference type="STRING" id="5866.A0A061D928"/>
    <dbReference type="GeneID" id="24563940"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205570"/>
    <dbReference type="OMA" id="YLMHCAL"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="5">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="323" mass="36520" checksum="356217DB22E8DCF8" modified="2014-09-03" version="1">MKKGTGKKCKKSGTEELKTEPEAKKQVLFMLSSSHSAETKQLLKDLFQLCKPSGFFRENYHNDVDFEDNVKIQINQYNHRIAAMVCNRMDCGLYVVASSNKKRPMGIGLGRIYDGKMLDCCQLRVTKYVPFDFFKGPNDLEISHYSYPLVLAQGAHFGEENGPMRTTRDILLDVFRPPATGMVSLESIQQVIVLTSVDADATNTADAPKQILFRRYQILFRKSDDDPKIPRVDMKEIGPQIDFELVDCMEADPEVFKHATAVARKPKKLVCGVDTETSTAIKRRKNVSTTALGHTEGRVYLDRQSLDKLYTPHTKTLKSKRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D951</accession>
    <name>A0A061D951_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP1/OBG family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769259.1">
        <property type="nucleotide sequence ID" value="XM_012913805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D951"/>
    <dbReference type="STRING" id="5866.A0A061D951"/>
    <dbReference type="GeneID" id="24565614"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309760"/>
    <dbReference type="OMA" id="SYMTRIG"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF44">
        <property type="entry name" value="GTP-BINDING PROTEIN OBGC, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="1">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="395" mass="44228" checksum="CF3F1C5F5ED1A3E4" modified="2014-09-03" version="1">MRSPWRASGVARTFNKDVAKVFGELMAPKHEETFPRYQTPFVDYLRVKCRGGHGGSPLPNVNRSQKLAGPGYGGHGGDVILKPTHLVESLLHIEETIKANNGGDAEGTSRGKHAKHTTVNVPLGVIVRKRIKTMAGYRSVFWHQFQEERHSIVVARGGKGGLGPSTFKKHDNRLPEVGETTHIELELRLINDVALIGRPNAGKTSLVSALTSYMTRIGPEEGSTTRPHVAVLRFVDGLDVRLMDLPPFSAENEQIYARILRHIYRTKVVAYVINAADDQGDPVDTLQQLRAIVKASNMYQQDKTELVVMTKCDMFHKEALYNLDKVYYKLRNETPHVRVVGTSATHRLGLQRLVNTLRELVHPKQVLYTPRETVESQEIKFIKQPDEPPGEIMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D981</accession>
    <name>A0A061D981_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769289.1">
        <property type="nucleotide sequence ID" value="XM_012913835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D981"/>
    <dbReference type="GeneID" id="24565644"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310060"/>
    <dbReference type="OrthoDB" id="10356972at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="27693" checksum="740604E0AC13AFDC" modified="2014-09-03" version="1">MWDLYIQDSDPSGGWESDSASENVNYIPLSPQYVNLRECSDCASSDYGHCCDYGVDVIDCCTCDQSAFDIPVVAARGSCNACHHATYDDRPKVLQFEGEAAFTTEKPAAAGLGAGTPSLQERRSVDKPKFTKKAVTIERGDQTVKIEVPSPPPSRPSIGSNNMPTRTPAPRRSVSAASKRNRAYMFCGRPLAGTQNTSYRNIVLPRAPGEKDVEIIAKRATNDRASSHEARIKPPQRGPKIRLAIEAPRRGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D988</accession>
    <name>A0A061D988_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768733.1">
        <property type="nucleotide sequence ID" value="XM_012913279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D988"/>
    <dbReference type="GeneID" id="24565088"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304500"/>
    <dbReference type="OrthoDB" id="415052at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="10107" checksum="AED11842527F1442" modified="2014-09-03" version="1">MRLSRALQKSIPLPRFSTSRLSRRDNMAEQERATFYYSNMFCVAITALPIAYLLKANYWSSPEQENLHFVLTHNEHHIKAPKQLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9J3</accession>
    <name>A0A061D9J3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0305600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768843.1">
        <property type="nucleotide sequence ID" value="XM_012913389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565198"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305600"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2224"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="861"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1459"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2288" mass="255981" checksum="DA2A8FDFF5FCD09E" modified="2014-09-03" version="1">MAPQFKKLTDCPENLREAIDWLIQVRHGNGNGDGLEHLGKALKKLIEEAIQKAYTTNFDALLNILNSVKSYTCCKEKVAKIEALKNPKMLAQNIFEDLKHFCESIRYCSENHLESSQQKSFGDITSKLEQLAKLKEGLTGFTNETQCKDLLTNLCTGLESFLGFNKDSKGYDGSGIVYSDLDRLCDGVMAFLKGVLEGVENEDAVGKYVVNVDEIIKFVNKKIGNGHAGFISAITSVESTLSMWNNMLTQRTNEVKGQLGELKDKHINKYSQNIEAVKNNGCTAINTSLMQSIVKLKAFMTNIRKNDKGFNGLDTGLQDKLNVPLEKVDDGIKILQNATQDDDFIKAVYVVQSTFAKLPKEIESSISENVKSTISGHESAVGVLKETVKKEVEKSRDAFLTERLAVFKEDLVKAITTFSKNAYNLGGLKNKTVRQAIEAIEKKLAKLNNGEETVEDSAKLQELRTVTVIPQTKSIKDALNEHAGEISTKLNTLDDSIDAPQNLFRTYENDLLRLVEKANDDLQKALKCARDNAKNLGGLNNIAVKTAVQQIQVKLDDADNITSMEKLKKLKTDLMDKEHIVTITDALNPKGSAVNNTIRDALNHIENPEIVFATHNKDLDTLTEKAKADLVAAVTNVTEYIETHGGMNNKKVKAALDKIESALQEFETLSIGVESLFRVVNAVDEEISGKVPSVAALSGLQAKLTGELEILKQRVRTLSDKNTTELKSLITSTRLYITDAIYIIECFGTTSEGKKEEEVHGVIGRLEKQLKELDDPFKGKNLRGFHSSVNEHLAKLKSDNVDFQGQGLPQLKNPHMPDISQKLIEARDAALNPLLDRAKGVVEKYITNAENYINISRTTSLNEFREALGRLKGNIQKLNANSVLTDFESQLTEVNSQFDSARDNPQGAAQALLPHFQEYIAQIKRQIRQTFIHAQSTAFQTAIDISRVEVGAVVSKAKKAIEAASQEYQAAMNGPRSRIDKAVSDIKEKASSDTLNTVTSNVSPDFEIIIQAIKQKSVFSDDSNERQKYFNELQGLITNTTNTLSEAYKNAYRSAAKSYLSGAIGKIRVAVTKAEDQYYQAIQHVNFDLTQISHDNFTKETVRTSLSATLTKPFATLLPKVVEYSAFSNDCSERVNCFTQLQSLITNKVSTLTAAYKSAYQSTAKTYLSKAIGMIKHEVVETEKKYKTVVAGTVMEIENIIIGLKADAFKNKRAHSALKTLFDAPFRVLQSTVQEYSAFKKDLDNRKTCFSKLHDLIAHMVQTLVEAYELFDRCAIKAIDHLRQSFDDAKSRIDRLGVDVKEKVRKAFDKVIGEVYDMFSKDKIALLKSLRICVEEQRKEVERIIGVDLKKGVKGLLQLLKIWLDKKSGDLKNAQNLKSLADLFKHLNKHLYRYVKFQYDGLELEDDSDDDDDDSLSSTPAVRLVPPPISGGSYRARPAEPTSQPKGNPLGRVGMPYKTASTDQQHPSQPTKNPIADHLDRLKVHSDRLFGTLSAGYFSRSFATKLEDVTEFLSSMRSSNFAGIGSPLFDILTLGLQSLTHELGKAYISAYDTQAYNFQWDTDRNAENCAKSFFTLLNNVYEDMATLKEKCVDKSKYGWKDKKICKTQKGTGNSLGAFFERCGYRVPTDDQGKQDGQLQCKDNMKGSDIREKLVESMIDTLNNSHLNACIKQKYYPEQTARTMYDLFDLLKCLFHHLDEYNEVCHLAIFTARRNPCSVYDMLIWLTGLPYNVARPAMMREGIGGLLENPNKALGGDDDGLLAYELDDFYLDAHPSKITYHDIDYTIHHISSSAYDIITCISGTGDDATFYGSDLCNNSFKFKYPTSGEECLDMLLDILRRLFPPLKFLLTQCSYPANLNGWSQCEYGKNVSTTKWPCKKHSTCRRNGQPNCEPKSPLMSYLNDCLPGHLPHQLTDIGCKYKCDTCPTSTPGQPCLTPLGFRGFSGSTKTGKDICRALNKFFDDRNLSALFGLSTKTPTTLPEHFGFVSCLVKGWVQKSKLVGDNIQQTFHKSISSRSISLYKEPSELTDALRNAYGDARPAHVDQSHLAAYAALSHLSMTTCSDPNQKAYCAPYITSLCGDSYTCLPFKNSNTYLSWAVYLPWDFWQLLNNFYNDFCDMLCQDWGCRTCLRADKCRRGKHGLVEKLDNKADSPHCKCPSMVQCRGVSPTLYRYGFVFGEASTLSDGNSKKLCSDFCTQLGNVLNSQYFKDLFTKCDEYLLAIRFPFMTLTLALWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLAKITYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U7</accession>
    <name>A0A061D9U7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767875.1">
        <property type="nucleotide sequence ID" value="XM_012912421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9U7"/>
    <dbReference type="GeneID" id="24564230"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208430"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="77" mass="8550" checksum="A608DD753E8B1C10" modified="2014-09-03" version="1">MTKTVTRSRHVCIGHGTCNADTCSCRRPKAKIQATSERVATAVSGIYYEITDIKRQSEVALPPVLKNEYITDTFETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Z4</accession>
    <name>A0A061D9Z4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0400280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769722.1">
        <property type="nucleotide sequence ID" value="XM_012914268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Z4"/>
    <dbReference type="STRING" id="5866.A0A061D9Z4"/>
    <dbReference type="GeneID" id="24566077"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400280"/>
    <dbReference type="OMA" id="RVSMYMH"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="3">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="259" mass="27801" checksum="407FE515EF0CA1EA" modified="2014-09-03" version="1">MSGTASGYDLSVSTFSPDGHVFQVEYATKAVDAAPTVAAAVCCDGIVFLSDSVLCGYDETTTTGRNVLQSKPALRLYALDEGVGCAVTGMIPDAQCIVRRAKAESKSFFEEYGVKIPISLLAERVALFVHAFTLYWHVRPFGASMILSGVDSNGKKSLYCIDPSGACYKYAGMAVGKCKHLVKTEMEKLDLAALSCREALKELSLAIMIGRDGDSSKTNDIQMAWICGESNGQFEQVPSDVATEAKLEASKRHAMLHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA60</accession>
    <name>A0A061DA60_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAJOR FACILITATOR SUPERFAMILY MEMBER protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0109280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766816.1">
        <property type="nucleotide sequence ID" value="XM_012911362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA60"/>
    <dbReference type="GeneID" id="24563171"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109280"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="578" mass="63892" checksum="B3DB4876C781F5DD" modified="2014-09-03" version="1">MAEAEDSASEAAKESETPKKIRPDYGAFGEVLYHLVSFTEGYEQQVLYLCVRTFESSLGFNKQQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSSTSKYSSILFLRFLHGAAFGCIYPVQQKIVADEDDEGDESSNSTFTRLHALNCIGRMLCAAITTEAAQNVLLGFVGWRISYIVLGYMWISVGIAIIYGLQAKEEVVSPYDSVNYFVTQLSGAFKAVFTSGTAFLSIFTMLIAEAPMCSLPYMITYLEYLGVSDKNVGIAILVTTIGGAAGTAAGGIVLEKIAGLHTDYGEMIAGIVVMGVRLIVCVLFFLSPAPDGRLMWYHYVEFAILGVTLVTVGGVDRPIMRKAIEDKYQASASALIQCISGISISVSFVEIFAYVSEKLLGYAPSTQTIDDMDADLKENNTEALRKSTMYMIVIGSLLNIACYIALIFTYKKERPEIKKKNEVWHKERVEKQTAMKRKKREEVAVQDPSVKAVEMPVPEETVSDKDTESSSDEKEVPVVEGGDTSPTSMSPTTRSDYSEGYMTEEEETKRREERQKLEEERTALARQKQNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA74</accession>
    <name>A0A061DA74_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Minichromosome maintenance protein 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0401080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769802.1">
        <property type="nucleotide sequence ID" value="XM_012914348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA74"/>
    <dbReference type="STRING" id="5866.A0A061DA74"/>
    <dbReference type="GeneID" id="24566157"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401080"/>
    <dbReference type="OMA" id="NVYPQED"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17706">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="6">
        <location>
            <begin position="410"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="833"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="961" mass="106807" checksum="3D7A201FFFDE78F2" modified="2014-09-03" version="1">MSRMRGYLMRDGANPSPSQRSSLNSERLLTVSELGTSKSMGTYSEDYSSLTSGYSSHRRGSTNTSTSDAERQLQLDRMHQQILAEYEGGRETLMIYQRSYRAAVERFLSFASENKQVYTKVMDLHQQVEKQFEKNQGSAAAQLAVHLRVIVNVSLLYFRSDDSNSSLAHMLIKSPYMTYQAFQDAIQEVWRTHTSKLSVAPPKLGICGWLGRHHVTPRGLCSSMINTLTAVEGVVNKCSTVSPKLAQSVYVGEPIYDMMHESEKTVHLRNHYDLTDFTKTAKDNGLPPSADPEGKVVHRQEIGLSSYRNYQTFVIQETPEDSFTGQMPRYVSVIVQDDLCNVVQCGDRVRVWGVYRAGCGRADDTNNGIGRGYLVANYVAIRNKLASRLSNEITDDDRAKFKQLAQREDCLSILTRSMAPSICGHEIVKRGLLLALAGGTASDESSDHRIRGDIHVLLVGDPGCGKSQMLRFVMNLLPGTVSTTGRGSTGVGLTAAVVVDQETGERRVEGGAMVMGDRRVVCIDEFDKMQPSDRVAIHEVMEQQTVTVAKAGIHTTLNARCTVLAAANPSYGCWSEDMDVSQQLCFERSLISRFDLIFVVRDSATEAEDERIAEAVLRNLTQKSKVITAHKNSAQSGRPGGAPSCVIQPVEGDMNQEAFANATFDGYHWEEQWVPTSGDSARAKKAKSAGKATDGFLKSRTEMTYIDCEGVEHDVVDSSFLRKYIHYCKHLFYREMEAMEGWRASPEISEVARRAIVSLYSQLRTRAQQSEQHRLKLPQAVTPRTLEAIIRLCVAYTKLQLKRWVTTDCVAAVGKLLNYTLFGDAYDVFETEREPASDYEDESMSEDSPKRTRPSRSATTDSAAAAPVGEITGGGEHRPSEGKAPRTAQSSEVDNNNTAILLSCLRKLDTGDGVDLSDLYIEFSRSVRMSMDDFKKFLQTLHNQEPSPIVYSEDAFMVFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA95</accession>
    <name>A0A061DA95_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Apurinic endonuclease (APN1) family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0307960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in mitochondrial DNA base excision repair (BER) pathway induced by oxidative stress. Has apurinic/apyrimidinic (AP) endonuclease activity towards double-stranded DNA (dsDNA) with a preference for C as opposite base. Has 3'-phosphatase activity; removes 3'-phosphate from blunt-end, recessed, and gapped DNA templates and thus, removes 3'-blocks for DNA polymerase activity during BER. Lacks 3'-5' exonuclease activity and does not cleave damaged bases by nucleotide incision repair (NIR).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769078.1">
        <property type="nucleotide sequence ID" value="XM_012913624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA95"/>
    <dbReference type="STRING" id="5866.A0A061DA95"/>
    <dbReference type="GeneID" id="24565433"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307960"/>
    <dbReference type="OMA" id="HPGSHLR"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="14">
        <location>
            <begin position="118"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR96892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="383" mass="42247" checksum="34503FC73AB1C9AD" modified="2014-09-03" version="1">MCAISNLEAASTTDSLVDVPEGETPSPSKPSALKTKKTGIEKKAPKKAVQTKLSFKAAGEKAVPWVTLPKLDPNEDRAAAFAEIAAASKRSGLYIGAHVSTAGGPDFAVLNAYNTCGQAFALFLKNQRRWDSPPLSDKSIKKFAENIEKCNYDLRYVLPHGSYLINIANPDPEKRKKSYEHFVDDIQRCEKLGITLYNFHPGSTVGMCDKSEGISNIANCINMAMKETSSAKIVLENAAGQKNVIGSTFEDLRDIINLVENKERIAVCLDTCHLFAAGYDIRTKTKFEEVMKSFDKIVGLNYLVAVHLNDCKSDLGSGLDRHENIGIGKLTRETFEFIANSGYFRNMPIILETPDIHGDETIYKQEVKAMYGLFNEEKSEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA8</accession>
    <name>A0A061DAA8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769093.1">
        <property type="nucleotide sequence ID" value="XM_012913639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA8"/>
    <dbReference type="STRING" id="5866.A0A061DAA8"/>
    <dbReference type="GeneID" id="24565448"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308110"/>
    <dbReference type="OMA" id="INRMFTL"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="438" mass="50046" checksum="D775F1AA11237F2B" modified="2014-09-03" version="1">MPATLHTQVQSWATEFVRAVDNRDGRALAILIRSKCDKLRLKGARGFDEAKIEQVCQKSFGKFDSVYGAEMRLFLSHYIKVAILISNGLAPWDEILKRSSKLLDIWMDLYLGLTTVDYNWLVPALHSICNLISKIGLMADRSSEDNGEFDNAEDSDKDKYMKQVLSNVRSKMGRVRGDDTRHPAYIILLGQSIKGCIQTTEPPTMLIHTAAGQHADGRGVPEDHRIANARSAINYSRALRGPLINYRYYLGKLHMQKGEYVEEHLVWAFSNTLQESIKMRRHILECIIVVRVGLGKLPSEKLLEKYELTHYSDIVRAIKLGDVKLFTDTVRRFSDVFTVQGTILCVEQLKYIAYRTLIKNAKSWWNTNVPETKPNMLSVELLTAIVRWQLPHMTDQEMLCICVNLIRRGLVKGYVSWERLMIVFSNVQPFPPIQSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB7</accession>
    <name>A0A061DAB7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769103.1">
        <property type="nucleotide sequence ID" value="XM_012913649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAB7"/>
    <dbReference type="GeneID" id="24565458"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308210"/>
    <dbReference type="OrthoDB" id="365505at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="134" mass="14449" checksum="4970989EAA295FAE" modified="2014-09-03" version="1">MSYRLREAGISSAEIVQMLRTLRCNTSTSPEAEVDPSLNERVCSILRRGARDCQLRKLHQSVANLAETLSVFTDAGVPEPMARDIVHNNPTLLALSKADVEALCSELLASGVDLGDFASILSQHSPHAAVPNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAC7</accession>
    <name>A0A061DAC7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0314050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769689.1">
        <property type="nucleotide sequence ID" value="XM_012914235.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566044"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0314050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0314050"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1684" mass="187663" checksum="69F287E229DFCDF9" modified="2014-09-03" version="1">MTSINHHNNLYGNGGSDGLTKLSQALKKLIEEAIEKATNSLNDRQSKLLCRGKPTDESSKDHPSVQPCCKQQQKTIDDTKEQLKSKLANQTDDSKKQIDELNAKIKKAEASKNDCAKTHYLPQEERQKGLQEVEQQREIVKKLETFAKELEKHANDNLLTHLCDGLQTFLGYSPNSKGYDGTGIVYSDLDRLCDGVMGFLSGVLEGVKDDDAVKKYDKSMSPNDFNRIINLLNDNNGKGAEGLKAVLSQVKSHLVSYQNKVSKEVTAVSGPLYELEDSVNENVKKVEEQKSMTLDKQFTAWSGQVKGYGDKVREANEAMKNIDEQLKKQLVAPLAKIDGAVNVLEKSATDDLKAACRVVDSSLGSQKQKLLSDVNKRVPELRIKVENKLDEVIKQIGHIGHIRTTRLTELIASTKEALESVKQAVDSAYDLSTIYERDIVQKIERIERQVEKIDTDDVASDLQEILMTVGQHLVTLGKLHDTITSELEHEFYDLKGKLYSDVQTLYGDIKQQVGGYLQELATAIKAGINTSSGVGRPRFSALVSTLNKRNPLEPDTDVGRKLSQANNGNLNFANAMESVLVYLKNASSANGGDPKPSDVFHALTTEFDSKIDSAQNQLNPLLRSAALRGTAAFKEALNLRINGRTHDVTGGIKKDIQDQIEKLDVASDDDMTEDGEIQKKIKTLQSSIDETEELIKKLRENAGKKDSDKDGVKDLVEALKDKVGGTLTNIHDVNVDLEAFNASIENAIQAAESTANSARQEIASGLETLISGLTAAIEVVFAGVKSDVQAFFATVREGQLSTFRGIIVEQNEQIADVIKDDEMNGVKGLLGKIKDGLNSLKSNNNVKTVTGLSAKAYSLLKNIVTYSNGDLQKLDRNFDQLQNFEKYIEKLASALNLYAHFSHPVSLRLSALSSATSALDPQALPDAGRPVLKALQAGMLGFVEELEKGYVNRYDGGESIKQWVKKGEKDVLTPEGKNGAKVFLTVVDTLFHELEDLRKGCKTNGKWNDEHVRQYEMDNGGDITPNSLGLWFSTHGFKVSRNEHEQNGELDRRKTGAQIMQYLMKQLNMPPNYKPIYDNQNQQEGTLNTLHEHLETYFRVNHYYIPPNPRAPTTVYEMLQWLCGLWYNPVRNGLIKTMVDLFGDNGELDVYMPEEIKKYLKRPALYPTTFMRLLPAVCAQSYTVLVGVQGHGHAEGRYACDFYTNSDKLAYPTNMNTLLCTLQEYLKRLHHQLYFLYEQCSHDSELSGWQDCHYGRHVGGSAWNCNAMQCVNQEGNQLGDQTCKQTCDQHPNCGLKSPLQSFLEDGLQGFLPHALSSKGATLSCSTCLKTPPGMPCRTPMGFPEISSTASHTKTGDHIYSALLDFCCTDASPLNVLCAMLNTLLPSAPKTLGDMFAFYSNFTYRWGMDGNEHKYKAFNDAATAANLEREYSKPNVGYLFSESHSAAWKGHSAGSLASLVCTSNDAVVCGPYLRPINKSIYVMFSSKHADKYLSWIVYLTQTFYDLLKKLYEECNSKCGSKGYNCHAKACIKGCPTTSSKETTPSHNEQCKSIVTCKYTMPTLCKYGFTLWDKHKLNGDDNINKKRTCKDFSTVFEETFKKDSHLVQFFTAIDEFIFTIRAPFIWLNVALWLLSVLYLIIVMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAGRVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAT2</accession>
    <name>A0A061DAT2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ubiquitin / ribosomal protein CEP52, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0110980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766986.1">
        <property type="nucleotide sequence ID" value="XM_012911532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAT2"/>
    <dbReference type="SMR" id="A0A061DAT2"/>
    <dbReference type="STRING" id="5866.A0A061DAT2"/>
    <dbReference type="GeneID" id="24563341"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110980"/>
    <dbReference type="OMA" id="CGRCSQL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="131" mass="14911" checksum="CF577C2F02EB86C0" modified="2014-09-03" version="1">MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLVILAQKYNCDKMVCRRCYARLPPRATNCRKKRCGRCSQLRPKKKIKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAU0</accession>
    <name>A0A061DAU0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767001.1">
        <property type="nucleotide sequence ID" value="XM_012911547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAU0"/>
    <dbReference type="GeneID" id="24563356"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111130"/>
    <dbReference type="OMA" id="HYYTFGG"/>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="361"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="428" mass="49210" checksum="CB557120487A729D" modified="2014-09-03" version="1">MTTNVTTAVVGTASAAAARRGRQLDPLTAGLKELTFRELAAAAETLAKTRVTDGNLWSRLCDRLKPELKSVHLGEALRVVHALAKVPYKKISLMNVVEKLVLQRHHAVGSRALTQYFIDVTRLQYIEPNTFQAVVQSRIDDLDEFSAFDLCFLLHVAAKLRLADSAIIDKVSHEILNNDDKYDVVCKVRWNPVDHTLHQDKALVAMVIRSLAFLQHRNRLFQKLVYSRLPGYIYTLGPQEMCNVVFSLVVALQDEEYGPEATNIVKVLLDRVSTHLRDLVDIEVNQLCISLFNLKHKLKPFDDKYQVLLDDIVTLNLTFPPSTSKMQYKIARLLDDLKVKHKSEQRIGPYVMDYVLPQLKVAIEVNGYSHFYHQTKEFHAITRLKYQIVRSLGWKVLSVNYFDWKNRSRQRKLEYLGEQLQELLRDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAW0</accession>
    <name>A0A061DAW0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition motif domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0310350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769318.1">
        <property type="nucleotide sequence ID" value="XM_012913864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAW0"/>
    <dbReference type="STRING" id="5866.A0A061DAW0"/>
    <dbReference type="GeneID" id="24565673"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310350"/>
    <dbReference type="OMA" id="GGFKKHN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="423"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="516"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="685" mass="73329" checksum="CC949C571321C8DB" modified="2014-09-03" version="1">MAKEAKKTKKQEIAAVEGSNATTSSESTKAVKGKKADKKRSWFSFGTKKDSSSSEDENPKEAMVQKPVAAQGSDGSDSESDTEFVVLPKGKSAKSAAKKSNASAGADQKKGKDVEKSTDASGAKKASAKKAAPKKDVIVEEKPVDSSEDDSDDTDSSEEIVPAKVAPKAEKPSPAKQDDSDEDDSDDEDSDDSDSEDEESEESSEEDEKSAKVDQKALKKAEEDSEDSDDSDESSDEEALPAKTSPKMEKKQEQKPAGDDSDDDSDDDSDDEDDDSDDEDSDDDDSDDSEDVVMAPAKTTGGKEKKAKEEQSNKMDVDGESDDSDEDEDSSDEDSDDEDEDDEDSEESSEEEEEEEKKKAEAEENEDGADGDDEEESDDSSDDEMVKPTPPPAAKAQKESKKPAKNAEKESDSAAGKAKGGRNEIYCGGLPFQITEEEVKELFESDCGPIVRINILQRKGIAFITFASDEAAQKAVEYNDTTYQGRTLKINITADRPKPARQPGFGEQDDVPQSGTEVCIRNLSYNSTEEGLRELFSECGEVVRCVIPKFEDTGKSMGRCFIGFASEEAAAKAVEYDNTEIDGRTVSIQYARPRAPRGDFRGGRGGFGGGRGRGNMGGRGGNRGGRGGFGGNRGRGGFGGRGGFGGNRGRGGFGGGSGDFKRRNDGGSIEIDPKKPKSIVFNDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAY6</accession>
    <name>A0A061DAY6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769899.1">
        <property type="nucleotide sequence ID" value="XM_012914445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAY6"/>
    <dbReference type="GeneID" id="24566254"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402040"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7998" checksum="4991F21EB2165483" modified="2014-09-03" version="1">MQRKYLHLKTGRHAVPQNETLLYFNALTGVSQLKHRYKNKDYLLAIYVASSGTYWGPNVLSVVRQNMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ3</accession>
    <name>A0A061DAZ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">-Vacuolar protein sorting-associated protein 11 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0402090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769904.1">
        <property type="nucleotide sequence ID" value="XM_012914450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAZ3"/>
    <dbReference type="STRING" id="5866.A0A061DAZ3"/>
    <dbReference type="GeneID" id="24566259"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402090"/>
    <dbReference type="OMA" id="AYSYYIP"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="920"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110386" checksum="3A37EEE434AC7938" modified="2014-09-03" version="1">MAASRRFHFFDKCFIAVSEAGRGSVGFEAVVDTAGDDAVLWVLESSGRLNALYRDVGAAYSEDSLRCVSVKAFEFEAQRVFSCSEASAVVVVGKDEESDSMLKFNTYKVTPQFDLENNELLHFVQSVPVFSPSQGLVLDHVQAVAVSPCASVVAVATAGGCVYVYRNYVIPPVDGSPHDHRLRSYSVGDLAGAHHLGTIRALHVSPLSSGVFGLAVCCDSMIVSLRLAPDPEIAYTQLIESSFESSCNLGSKGQFVVAKSGGMLDIYDIESGFVNAVKGSESCASICAYKHYVATASLECRGGLEASYATTLVNVQSIVPGVDFVAHSQYIPVVFKFERALRSLYVFARSGTSSALILFELREKGIHDRLQILIRKRMFEWALRIAALERRPLSECEELHKIHANWLYDKGHYDLAIEAYCRAGSAVEPAFVIGRFMSLRARFYLYKYLLHLHRSGSVSRIHTVVLMRALQSLFEDRVNGGCRLDAATPADSVGATGASEPDSNEVDCQQLLSAFLSEFGDSHQDGIMAALSDCRSSGGSDFARVVALAQQNHDQYVDILVEDFHDYSSALDYLMTVDRQVACNAILRHGRRLVKHNSDAVLSLIRKIGESMPHSNGNVHDAFVPIFCMEDRFLSEMLGSDGPCTQLLIFATRLHLMLDQFASHRRRVMDDTSAAASSAPTNGQSTQQHPTTPPPPSDGTQAHKASALDECVGSAGPLAVAEAPSAAHADGEFDITGLENRMWKLLNGNTQHAEYQMIALILCLLYSYQRGANLMAIKMGYYHLPLVLAGMGNNEINSNKFDLLNHALSYGYNEPTLWIGALSLLVGASNDTSEEIRGTLRHIQTHRLLSFPGVLAILKKKQTLQFGHVKEYLRNEFRRIEELLQECIGDIAQDKIDCGQMNRDLQRLQHSYFVINNTNCSRCELCLEMPSLHFYCQHSFHTYCIGTDGVCPKCAPATQDGPDGGRPQKGSGHQDDFFKFLSGATDPFVYMAQQLERFAFARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBC2</accession>
    <name>A0A061DBC2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768390.1">
        <property type="nucleotide sequence ID" value="XM_012912936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBC2"/>
    <dbReference type="GeneID" id="24564745"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301090"/>
    <dbReference type="OMA" id="FKWWCDE"/>
    <dbReference type="OrthoDB" id="364495at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="588" mass="66543" checksum="294BED5B8CC8947C" modified="2014-09-03" version="1">MSLSLETSAGYIDSEYSDFEHVDPLSTIEKSSPKFGRDDMKYLADRNVAPGLLCGIEAISEKTPKTSGRDNMTLSHNYVDHTTTKSFISGRHNSRRDDRFSSNREFSVEYFSDESCRADTVNNGFKWWCDEQEASDFSVANTGEDVTPIKFESVVPIEERKMLDALHAVQLGNPQQMSDRTRCGSTSSDDCESNESLCSAMSSPRELPEDQEEEWSSFMKPADSDVEVDLLKEQILHRLGLKLTNVRMKGPLEKQCNRKCDAASQTSEDGFVSAYKDYEIVWLRNVNGMLSKQFIELISGGKLMAYKTDQRFIESLQSHLSRSQTEIDRLLRINPDPLNCKDECPNDSNLIDELAMIKAQNLNLKKEVEVLKAQLRQANETDSFVERVKALEQKLREERLSKMALMEDFNKTLGYMRLMKDRLKTLSEEKCARLLTPSSAMTDFPGRFNAGECTSKPAVKPNTLKGCVKRSNTTSCAPSKQDRVKFAETSDVYYLPKRSNSELGPFLVDSKRQMPILPCKIRPVDPKAKSENNSGLMGFIKSIKQTFSNKLDQTSPRANVLKIPNGQESQTQQKLAMYKRHLLSRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBG5</accession>
    <name>A0A061DBG5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0301480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768430.1">
        <property type="nucleotide sequence ID" value="XM_012912976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBG5"/>
    <dbReference type="STRING" id="5866.A0A061DBG5"/>
    <dbReference type="GeneID" id="24564785"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301480"/>
    <dbReference type="OMA" id="IMEIWNE"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="8">
        <location>
            <begin position="277"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="854" mass="95445" checksum="FCC2F621D20A6392" modified="2014-09-03" version="1">MNTGEPTNVDTEDDLEDWLESELLPAGAITVPEDLHLPSKIRWIVSDGANVVENQVLATFSFVENASGIGKEHVKSTNSDDGVEVASIVSGREDTDTSRSLPSESGDACVSTKAYELDGPSHRSSLSNTQADTTDSKAVISALTNGSRGVSIELVGRATEGSFVLRSVRHGTLRHRVPTDTVIEDYSAVLGTIESVQCEHSVVIHGLCVTCCQVVDDASTKRRQDVAPGNSKRQSPGDKPSDAPEMVVPGFITNNNAVLVDAKMSNEMELMELLRLLRKKKLCLVLDLDNTLIHSSCAKPPDDIDIPFIDMYSRSQGYKLHFDSEEDNRRYEAELESSILITRTLNEQDGRFFVNYYKLRPGVYEFLRNASERYELYLFTMGTRTHAQAALRILDPKGLLFGSRVFSRSETNNSYKSLCRIFPNYRNLLLILDDSEHIWMNPPGLIKVYPYYYFTDMSLIRNRDSRNLGRVSAALQAHCNYSNYVWHSLIMEIWNESESRERVTRDDDGFTIPMNLKMPKKRSPSFRYNNLLIANCRPSNIYRDTAGADSASVTQRLSDSAAARAEPAVLQEVRPAEPRPSDDKRVLSEVTNTGINTEADTRAHSADCNKDTKGTIPQAERVAVTQKDMEPTADACKRSESGDSSKTLPPNQVASPVDAPTDFAEAAPPTAPSTQQNSCMRKLRKIWVRDYDSQLPCVTRLLIEMHRRFFELVNVAGLTLERLKQLIGGNALPDVGVLLNERRKSVLRGVVLGVNRNDFRCPRTGEDVDFFNKSDLGYLAVRFGAAPPSVECSMTHYLNNNTSAVAPKAGVKRVHSQWLEACIHTWSRVDESLFDPETWKEPHRTFWDVMNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBG8</accession>
    <name>A0A061DBG8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase, group 1 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0311950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769478.1">
        <property type="nucleotide sequence ID" value="XM_012914024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBG8"/>
    <dbReference type="STRING" id="5866.A0A061DBG8"/>
    <dbReference type="GeneID" id="24565833"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311950"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="4">
        <location>
            <begin position="74"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="219"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="471" mass="53174" checksum="BB1D3555DD90CAC9" modified="2014-09-03" version="1">MARKRAKDPPKPTDPAEADDGAGSTPLKPRRRRTILMVSEFFYPDIGGIETHICALSTGLIELGYRVVMVTRHFGDRRGVRYLSNGMKVYHIPTIFYIKPCGMPGFFDTFLLARNIYIREQVDIVHVHQTTSRYASEFVHVAYIMGLKTVFTDHSLFSFTDLGPITTTDYLKHQAVVLNHTICVSTTHKENLVLRTQMDPTAASVIGNAIDPDIFLPSETSRNDGRIIIVVVSRLTLKKGTELLTDVIPIVCKRHENVDFIIGGDGPLYASIVECVDKLYLHKRVTLLGAVPNYKVNAVLKRGDIFLNTSKSESFCIAILEAVSSGLLCVSTNVGGVHEILPHDMVLLANYSPESIANRIDDAIEMLPSVDRQKLHSRVRQMYSWARVAGEVSRVYENVVREPRRPVIDVISIYWEIDTIFRGLLIAIIIFLYAEWWIAELLYPREEIDIAPDWSIHGSQMREETSETKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBN6</accession>
    <name>A0A061DBN6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Replication factor C subunit 4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0404600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770159.1">
        <property type="nucleotide sequence ID" value="XM_012914705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBN6"/>
    <dbReference type="STRING" id="5866.A0A061DBN6"/>
    <dbReference type="GeneID" id="24566514"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404600"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="306" mass="34377" checksum="78393E9043E44B1F" modified="2014-09-03" version="1">MTTDIWIEKYRPSSLSDVLGNPEITRRLEIIAKEGNMPNLLLCGPPGTGKTTSILCLAHEMLGEHFKNAVLELNASDDRGVDVVRETIKNFAKKSVVLPENKHKIIILDEVDSMTEAAQQALRRIMEIYSKTTRFALACNQSTKIIEPIQSRCAVIRYGRMKDEMILKRMVDICKMEQVQFTQDGMEALLFTADGDMRRAVNNLQNVSSGFDLVTKENVFKVCDVPSPDLIRKMLQDCLNGQWRPAHEKALELLALGHSPLDIVVTIRSVIKAFKAPEHVLLEFIKTVALTHMTMVGGLCSQLQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBS3</accession>
    <name>A0A061DBS3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768500.1">
        <property type="nucleotide sequence ID" value="XM_012913046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBS3"/>
    <dbReference type="GeneID" id="24564855"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302180"/>
    <dbReference type="OMA" id="QFPDPIL"/>
    <dbReference type="OrthoDB" id="361154at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="314" mass="35177" checksum="213629A5F6ED9435" modified="2014-09-03" version="1">MSMENNNGPVTRVIRLPQGHYRRVGSDEAPEFLKDVNLDVPSFEDMKQCCENTCFISDEEYSKLKPNSELYTGDASLTIEEEAAVDDAQLFYEVYSKRLMTGVSETGVQTSFQQDNSVDVGVGTPRENAEQRAGDVEKQDGEGQGEIQMTGAQSALIAEGETGEMTEEMKAKQLAATEKLNMIGGPMHIDCNSPDVFKNGGVPTLFYTKSRESPTLVMLSIDYEMQVIYLSRNDINRFFPIKLISRLVTNTTIIAEEFERQIEADKGIRLDNTIVLNAANFTDSVAIQFPDPILKDRFIEDLKQLKNEIRAQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBS6</accession>
    <name>A0A061DBS6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L36, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767391.1">
        <property type="nucleotide sequence ID" value="XM_012911937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBS6"/>
    <dbReference type="STRING" id="5866.A0A061DBS6"/>
    <dbReference type="GeneID" id="24563746"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203630"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="25649at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="116" mass="13066" checksum="F7B6BE271613D201" modified="2014-09-03" version="1">MAAKKEMKIDPARSGIVAGLNKGHINTAIPLVKSVRASRRKGLKTNRNALVSEVIREVCGFAPYERHMIELIKTGSASAQKRALKFAKKRLGTLRRAKAKNDEMMRVVELQRKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC07</accession>
    <name>A0A061DC07_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769713.1">
        <property type="nucleotide sequence ID" value="XM_012914259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC07"/>
    <dbReference type="GeneID" id="24566068"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400190"/>
    <dbReference type="OMA" id="PFKACRG"/>
    <dbReference type="OrthoDB" id="364703at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="586" mass="66323" checksum="344153C81246C5CD" modified="2014-09-03" version="1">MSTMQVSSNDAKEYTVFPSADSIRKSGFLDVDVAGDERCALMLSEKASKTYAMRHTPVNTDDFNSFIEDSMNHLDHINASRGDLNTKTIGSSVLSTVGQRSWEDAVVDCRIELFDQSLGHNAIKPTDNRFGKNVDEVFHHNFTRQRTLYDTGLEDDDDLIYLPSSNGLHSSHLSSHPEDSADNNISPTRCFSRIPKRNRIQPDTHLTASEFWRSQPVTPLTDKAIASVFAKFTHVETGDRGFDNYYAYFHDEDFSKITKEPNMISILPRGDWTPRDIKMCGPFKACRGEASKISKSGGPIYGDGFNNGSNKPQDSAVSPLEGLFMVTADIDSDDDVESYEHLYKAELDLLVERGEQVDLQEMDEWLYQAGLTAPQVKNHQMAFRRLLRLNCNYFGKRVYPYRGEFDSLASKTLHVLDPDTNSFEVSPAMAKPEKLDLRKLKKRPCMDRESVIESPTNDGAAGISVNTTIPLSTHRLFDYETEPRFIRNPTLKVGASNVRHLYGEETSCSFMKSQSFGLRHGIADFQIADTTRQEDFQVPPTLKQLFPTKDKYINSEVALMNQRNFILKVLLRFPYLDLKQLGLTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC80</accession>
    <name>A0A061DC80_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">-Poly(A) RNA polymerase GLD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769833.1">
        <property type="nucleotide sequence ID" value="XM_012914379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC80"/>
    <dbReference type="STRING" id="5866.A0A061DC80"/>
    <dbReference type="GeneID" id="24566188"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401390"/>
    <dbReference type="OMA" id="CVQIPNV"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="172"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="509" mass="57033" checksum="C08EE318A81204A0" modified="2014-09-03" version="1">MTRAMCKESVKVAWSRVLHSHVYGAALRLLDQFVRLERKQFQYCRSAKLSSARAVDIKDENRGTDKLENQIEDDAYARETFNGDASSHYPFNLADVDRRRNWRTAFSPFKKRAAEIKHVSANQGRSICQDVDLKSIKIAGENESVSTEASRKGGVTGSGTAERSSEPSYTNKSALTAEQQSLRNKSIASCIESYLRERLNPKCSVGVFGSAINGLWTDASDLDICVQIPNVTSRSAIIRNLRRIAFLLQPLAPGRAFENRFTAKIPILHWKNEKPNKRIGDPLIQSLGSSIDISVNNVLAISNSALLGTYVACDSRVKDLVLALKKWARCRDLNDRSKGTLGSFALSLMAIHFLQRCNPPVLVSLQDLAIADNESPKYVSGIDVRFTTNMRRIKEELNWASKGVPNGMTVAELLQAFFYYFGWTYTKNTQLPICIRSVDFQYMDTPLSFAHKSAGIDLDEKFMHVDNPFEVGVDVANISFHQRIRIVTELRRAYQILRAGGSYDDILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF0</accession>
    <name>A0A061DCF0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0402450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769943.1">
        <property type="nucleotide sequence ID" value="XM_012914489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF0"/>
    <dbReference type="STRING" id="5866.A0A061DCF0"/>
    <dbReference type="GeneID" id="24566298"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402450"/>
    <dbReference type="OMA" id="FVICRSH"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="4">
        <location>
            <begin position="494"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="650" mass="74040" checksum="B4924625DD95629A" modified="2014-09-03" version="1">MEAFMLVADDGLPFEPLASEVPVCDLYLGHNSIFHETLENLWGSGITRVSLVVEKNKESLYKKYERKYQFGRRQGHVDVAVLALNVDKVLPGNVIRELTAVLGGLEDFVMLYWNTLLTIPLFDALELHQSRTKERQRYSMSVLYFEDDRQKRFSKLVDDCMIILNAQSEILAYGPGADDLEINKEWLRRCGNSTQFSLRYDLCRTGIYICNKQVAEHFGNWYEHQEMDEYIVDCLNREFKTDEVYATILKADIMFPTYPPAIRIETPKDYHTVFMEYIKRFEGDEAPSQKLTATHNPQCGPLVHEGVVVSKNNIVGKNVKVGEGSDISRCIIFDDVTIGAECSIHDSIIMNGVVIEDATVIPSGSIVCSNANVTRDMVKGLTHGLRASKMPTRYIDLTTPEGERQSLLEQGDGVHVWPVHAFGKLEDTYIGKSFYDLVDFKVPSQQSTALGSDDESNDEEDEREGSRRRSDDLDSDDEASLSDSESSDIYDETTNPQKLMKDDVAEEFKTLIVECLEAPSQLPNKVLEIKSLKISHNLKKADMVKATLIYALEWVVERASDEGQLQGLIEAAQLKELLDTFEHEMDELDHYDDIFRACSEKQKDVEFFSYLCEALYHSDIMEFEMLHDWLTRNGISGSRINSFAQWLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCP2</accession>
    <name>A0A061DCP2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770103.1">
        <property type="nucleotide sequence ID" value="XM_012914649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCP2"/>
    <dbReference type="GeneID" id="24566458"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404050"/>
    <dbReference type="OMA" id="NADSAMC"/>
    <dbReference type="OrthoDB" id="366159at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54935" checksum="28460482BD744955" modified="2014-09-03" version="1">MIRPAQNLIAKAFGQLAKAQYATSAGHQASFVWKMPWQQCSIFETKKDTGSPHQPRAARDEIRKQANRSPPAQSNASDHDETQYIHQIFRKQALPKWNASVYVKALQNFAYLQPQQVDKAADVVAQLVRTIAQNINGLNNYEITRIIFACSKGRLLQNTYITRSFVRLLENEVMQRLDTLYAIDLFRILHSVTHINADSAMCPVEPIYSFAEPDDMPFDPSMVKHIIGRIVDRIANLGAMDIANLTCLIAYNGMEDDKILRRLNSAIRRRLWGTKDTIKVLTPIIALAMFGDLSTDTAVGVLSRLVNAEQNCALKAMRSISTLPVYGLKNPAARENWKILQVVNNQLYPLKLLEMTLRVDYQQVYHSIDADNRAYLEQIRYLMPTLVNADDWDYVKITDTPERPNANTQQKHTDLNLVAHIYGPYVLRECDPVRKVVVQDQVAWKNMNSWQRFYVHHYHKMQQRHLEHSGFKIVCNTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCV3</accession>
    <name>A0A061DCV3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770208.1">
        <property type="nucleotide sequence ID" value="XM_012914754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCV3"/>
    <dbReference type="GeneID" id="24566563"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405070"/>
    <dbReference type="OMA" id="CEECELD"/>
    <dbReference type="OrthoDB" id="365137at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="487" mass="54007" checksum="4F74F80A33DCFEC9" modified="2014-09-03" version="1">MPYFQLTPHQKRGCVVVETLLCGYKGNVRVTFDRNNGRLLIEGNDGSQHLEFVPTVRLRKSDAEIPFKTTTYIVELSLEHAKYSCSNTSVRCHQTFASVKSPNPHLPDVTQGNTSDHQRTISPDFSVSSLPRGRTGCNILSCGIPPGLKDCSGQPTWVANFLGGTFEGHSEVPCEKSFTVAIRDLHISSHSLQDIAVHTRDGLCFLTWSIVVYTPNLPHLDLRIATLRETESNVGLKKYRLLVLRCKRCKHILESVEDATIVPLPTEFFSSITGSTFCEECEPQLLSRVPSLARVGHIIYQGEDVITLYRPSAVALKERAALCAQCGYKVGLYSDCDHQFVSYSKRSISASADDRPEDIFWRHTEERAAIEALQYNNGVKLFIAGSVEAPAQISANCSVAAVKEELTNGSCCIELIKVTSQPDAFVATSDTVIDASRVLWRLVKKPERASPIIWSQDLYDHLVDVLRYFSQPTDPVTGFTPSLLVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCW5</accession>
    <name>A0A061DCW5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0405310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770233.1">
        <property type="nucleotide sequence ID" value="XM_012914779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCW5"/>
    <dbReference type="STRING" id="5866.A0A061DCW5"/>
    <dbReference type="GeneID" id="24566588"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405310"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR98047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="488" mass="53610" checksum="4EADFB85F5E3C18C" modified="2014-09-03" version="1">MTTSVAKPATQKSTKKGDYNVLAKALYFMVSFFEGYDQQVLSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCIIWGLLADENDSNHVLGAGLILMGIASIFLSSASHYKVILFLRFLHGFGFACVYPVQQKIVAESTEQKESEIEQTQQPSESQSSTGETRKRKKKSNSIFTYFQALNCIGRLLCAVITTIIARKVLLGYYGWRTSYVVLGYVWILFGIGIECGMILQKGKNVQQCDSQDGKLAQRIADSFSEVFKKKPTALISIFTLFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSGAGGEVIEKMSEKYDHFELGSGIAVMVVRLVVCLLFFLGPAPCGKLLWYHYVELATLGGTLVTVGGVDRAVMKEVIKDEYQGTASAIVRTISGISSSVILFQVSAYLTEKIFGYVPSRESFETMATDIKERNAEALRKSMMYIILAGTVLNVICYVAMFFTYTNDKEKGSSETKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD44</accession>
    <name>A0A061DD44_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable rRNA maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0210890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768126.1">
        <property type="nucleotide sequence ID" value="XM_012912672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD44"/>
    <dbReference type="STRING" id="5866.A0A061DD44"/>
    <dbReference type="GeneID" id="24564481"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210890"/>
    <dbReference type="OMA" id="HGMLHLV"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596233" evidence="8">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="30909" checksum="43A46784D6D46B0D" modified="2014-09-03" version="1">MHFDVYIILALRVLWLGYWACLRCSQPVAGFGGRIRSLLPYNHAYIHASHPSIQRCCRQPRSSSLCAAGESTAAAPPNDITVVNSQSDHGVDERLIHDACELYRSKLGFPDFSVDVLILDADDMTEANMRAFGKNCPTDIISNAANSQHTRKQYHLNRSPQQVAESRHLGEILLCPSYVLAQMTERQGSPLEGSMPTRGQPGDFNDLKHRGVAVRMQAISDLNERLCYLLAHGFLHLLGYDHVADSDYEEMLAEEDALIDAFVTFYRSRSADQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD76</accession>
    <name>A0A061DD76_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769350.1">
        <property type="nucleotide sequence ID" value="XM_012913896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD76"/>
    <dbReference type="GeneID" id="24565705"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310670"/>
    <dbReference type="OrthoDB" id="10383786at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="156" mass="17705" checksum="DBBDAD383EF9A968" modified="2014-09-03" version="1">MVSFKNRFMSVNSWVQGNQHAKLRRQLDRLHRQIAKEIKLRVKVARNELAQCDYSRVLSNAKNALVTYSTAIINGATRGTESVSVTGSVDHKSLAKQKVLCSQSEKKSRSSTFKKEESEFNNFINGLIRRVDKCAEVHRKADTYDEDILDALCATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB8</accession>
    <name>A0A061DDB8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0311620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769445.1">
        <property type="nucleotide sequence ID" value="XM_012913991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDB8"/>
    <dbReference type="STRING" id="5866.A0A061DDB8"/>
    <dbReference type="GeneID" id="24565800"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311620"/>
    <dbReference type="OrthoDB" id="360484at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="113" mass="13032" checksum="2443AE4D0345EF33" modified="2014-09-03" version="1">MEKLDFSQAAQNAQAIPHNQQEKQMQEEAKREGILEARRMTMRTLLTVDAQERLNRISMVKPEKAAQIENYLMQTAFRAGRSHKMDDAELKNLIELVEAKGQRLGHMQSHMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF1</accession>
    <name>A0A061DDF1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone-like transcription factor domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0301300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768411.1">
        <property type="nucleotide sequence ID" value="XM_012912957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDF1"/>
    <dbReference type="STRING" id="5866.A0A061DDF1"/>
    <dbReference type="GeneID" id="24564766"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301300"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="196"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="290" mass="31632" checksum="4EE7C1A35E9716ED" modified="2014-09-03" version="1">MTPICGNVSGDGYDHTDPMLAARSYEELLISASKAPGEAYENTIKSASSPDLSKRRDNLSSSFTYVSVEHAQGSQAHDAINARAVNDNVENTDIAANTMVSYSYTSDAPRKYSVQNLDTMRPEGTPSGSFRKSDSTARSSAYMSRPAATSCNDTQIPFSYEPTAYASHSGVEYDSGSQGDVSFAAFERRDVENDLTLPIANIGRVMKSVLPATAKIAKQAKDVIRDCVIEFILFVSSEASDICTHERRKTLSADDILVAMSSLGFGHYNDALRCYQAKIKEREPATMFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ6</accession>
    <name>A0A061DDJ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769670.1">
        <property type="nucleotide sequence ID" value="XM_012914216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDJ6"/>
    <dbReference type="GeneID" id="24566025"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313860"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="193" mass="21421" checksum="5B060932CE62C233" modified="2014-09-03" version="1">MDNTCHNQDNPMYGIYHFFAAHSRTHDIRDKTDILYKTRSSIDNHAAYNHYDTYICSNSSSRFPPSPLNLQAYQSPSKALTNCNTTTAAPVPSTCEHINHLAKHSPTATLPLPLPVPSTCKHQSPMQALTNYNTYHCRSQSPQPANINHLCKHSPTTTRTSAVPVLSSPRTLTAVSPQSRPPTPTLPRIPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDL8</accession>
    <name>A0A061DDL8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mak16 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0302690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768551.1">
        <property type="nucleotide sequence ID" value="XM_012913097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDL8"/>
    <dbReference type="STRING" id="5866.A0A061DDL8"/>
    <dbReference type="GeneID" id="24564906"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302690"/>
    <dbReference type="OMA" id="WHCIRHG"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="214" mass="25080" checksum="824F8A3DFC2DEB54" modified="2014-09-03" version="1">MSDDVVWQLIKDDFCAYRKWLNWRSTDTTSFCTNAYNVTGLCNRGSCPLANSNYATVIEDQGSLYLCMKTAERCHTPREQWERLKLSKNLKESLSQINEATKVGIAAYLTQKCRLRLKRWREVLQRMRREALSQKTKVAPIKRKTERREAIRERKAEIAARLDNAIEQELLNPKRMQRCRVLTAADHEVCFSANAPRMHMEIEYDEDFARDVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDX4</accession>
    <name>A0A061DDX4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768846.1">
        <property type="nucleotide sequence ID" value="XM_012913392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDX4"/>
    <dbReference type="GeneID" id="24565201"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305640"/>
    <dbReference type="OMA" id="MRISEWI"/>
    <dbReference type="OrthoDB" id="2192644at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="222" mass="25755" checksum="61EE35C07173B16C" modified="2014-09-03" version="1">MGGTRGNNGKNVDHLATKWPKLLHLEYTKRHNEVAKRVQSVLGRQIGLPKEKIDAHKIESQVHVKYGWIAYEMTVKTRKTKEYNRPDIILADRRRNTITIVEIVISNQDNLVDTEKFKKQKYEDLIGDLKIRVIPYVMTWEGIVTKEHSKYVRDLGISDRTEAHEQRVVIQETDKIVMRDMKPREDYDSVEDPRAQTGWMPAWMAPVTIGNGPTWIPQPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE24</accession>
    <name>A0A061DE24_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase, GNAT family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0306790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768961.1">
        <property type="nucleotide sequence ID" value="XM_012913507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE24"/>
    <dbReference type="STRING" id="5866.A0A061DE24"/>
    <dbReference type="GeneID" id="24565316"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306790"/>
    <dbReference type="OMA" id="RGDLIIW"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="244"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="366" mass="41958" checksum="F61A31F6CAD687F5" modified="2014-09-03" version="1">MFDFLKRWRKPAETQQPRGLRRTASLRRINQSFLKIREIDTDDEGDVRKLLFDHFRSLTIPAMVYWVVQHVHDLVAIIVIMAFLLPIKSLLYFCVCFLVYLYIRARVEIERHIRWCCPDLESVFDTYRTTEGSNFWVGYFSKHEELGTATESNTEAAATPVYTRAEGGGDDNNEEREPALSGRTEPDTDASGTQPAGEGSAARHDSVPLKAPESESQPQLRLKRYNTMSESSVVLKDVLMPNCKENEILGCVGITPYRNKSTVAQMVRLVVSKKCRNMKVGSKLLNHLETFAMDFGYTEIRVYTNNLNTAYLQFLKQNGFVIQQIVRRGFMRGDLIIWNKTLSQPNDLLVTEMPLLRKVDASFIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE62</accession>
    <name>A0A061DE62_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769041.1">
        <property type="nucleotide sequence ID" value="XM_012913587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE62"/>
    <dbReference type="STRING" id="5866.A0A061DE62"/>
    <dbReference type="GeneID" id="24565396"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307590"/>
    <dbReference type="OMA" id="FVGIGSC"/>
    <dbReference type="OrthoDB" id="361911at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="678"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="842" mass="87620" checksum="A3247B06B0A59836" modified="2014-09-03" version="1">MSDIGFSGGSQDPWQQLSGRSSKLRVPNRAVLTRNVPFGRHRPAPEVIEHMLDDLEERMRNYFTLYNRERELRRQSEATAYRLEQELVEERRKLAEANTQIEHLDGKIRALVGQPLKIRSTIDKIELLYNQLDTLVQAFVGIGSCATLQSQNRAAFLRLFLEYLYPCRDLDVRLNTLYTAIYASMPHVGNALDQQPLPTPAAPAPAPMPSSTEPATPSAQLRGLSVTVHQLMLKSSKFTNETGYYSCAFRYDNETAEFALSTPSRVMKVTARPMDNASGVIEVDGCVSVQQLPPRIPNVLPMLILDVYSGNVLLGSCQMSIVDNRTLNSREPWQIMDAGGNHCGDLIVSVRGIPDGAKLPAVNFIRRTDELMMSQVPPADANKPSQLEPTVPDKVSAAAPATNKAPSVSKPEVKSKLPPTRATAPPSTPADSPFQPKQKAVLRKPLFLKSNKPTPLGAPAKAAPASTEPAAAAAKSPAPSKAAAPSDAAPKATPSITKAPLLGKSSLPQAADSKAKSPAPEAAASKALPTKAAPMVASKSNASADSTPQPDTAPATPKVGLKAPLGKALLTPKVTFKTPLTTKAEPPSVATKAATKSLATPTKAPVTPTKALATPTKALATPTKAPVTPTKAPATATPEPAEAPAPAPAAAPKAEFVPAKKAPLLAPKGVSKAPLGIAPKTAPTTDAATPKTAPTTDAAAPKAIVPKVATKSAPAADTPAAKEPAAVTKGPLIAPKGKTLGVAAKTALPLLAPKTAAPAVAPKTADGGISPKNAMKSIAPKVALPAVTPKTAPAGITPKVAPPPQPAGSGDAPAGADDKKPLVPIAIKPKFQLKKPLAVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE2</accession>
    <name>A0A061DEE2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769311.1">
        <property type="nucleotide sequence ID" value="XM_012913857.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DEE2"/>
    <dbReference type="GeneID" id="24565666"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310280"/>
    <dbReference type="OrthoDB" id="10533248at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1770" mass="193024" checksum="D73488B4D147601E" modified="2014-09-03" version="1">MANIQLNTLKECLQFLEWLRQDANMRAQVATVLHGRIKNYYKGKNTEHDIKQSLNHFLNNVSAFYTRLCYNPDAGKYRNQNPNDIVNTLLECLPKFLAAMYYLWYCVNPTFDKLGGGGWKHDWPGGSASWAGDYGGDLDKYLQAQSNETKYGGMMPGGFAYGDIKYNKASGYYQGYNMAVGLENILNKYRNMHNFFSDIFVTSTLSTAGIHKVNAGNAVALVGTFCGIVKQKDESFRNNVESPGKPICWQDLIKHCAHLQRQFGRMFTKKRFDHTGQSPESRKLNEAIFAKETANWFRINLDNVKRTLEGIKPYYGDLGGYFTHNLFPYGFTFFSDHRYTAQSKDVETLKNDWNTVIGELKKEGDGLAKLKKILEGEYRVSCPVRPPPEPAVPSAKLPNSPKQVIPENKSSPPTETKSTTTKAKSPQGKKANGAPNQGTTGNGQQNPKSSNNASQNQNRGQSGGKPPTSSTTTTSPSPPIGSAGAPGPAGPQGGRGNKGPDSTTSTTSTLKNTVSPQQPSSPQPVHPSPASPTGHPAGTGSPGQSGGGSGSSNGGGAPGQKAAASPAPKPQTPSDTSSRPQSSVVPAPGGVPSTGSGHGLPGAVQPGGNGRGNDTQGGGLKTQQPATSPQNLTTQLSSVQPERSGTPGASAPGAGNGGVPGSSGGTGPSSSTTQQNGRGTPQAPTTATTTTTTGSGAGSGGGGGVGGAVSSPGTAGKDQGAGNSQIQKKCPEGKSLMSLWPDGPEYCVPKYDFNDPKTTDPVWDKVNEKLRDEDIQKTVERNIQKQNSQMPHPPRRQTRPDNPNAVLPAHSNSRHPGPQHHPIDPLRSGDVQVDAIDVPTPVLGGNIIKPKSQQFPPYDLDALTGITVSVAPDLKLQSFNDIQNMNASHNKMSTIRDRLYSRSHMRVGNVDISRPSPPISVEITKAVSVDKDDIKKPLMAGGYPLAALDVQGEVLHGFDDSLAFELSGEEIPEESDHILQKEISAQAQWQEMQKSDMLTGIQRDITQSAKRLDEGAVFVSGDKIEFPQPADMVGRVVKNNANSELKRMQEAQKYIRSNDFAVTGDIIPIPNIPPKPLPLLPAIGIPAGKPLKEAKQISPLPPLPYPLSVPAIASEPEGIDLTKQKRTTERTPVILPEVIPPLTGQLDVLPMENSTDFFGTPIVQTPSHIPTVYIPQDSAFETFVPSEPTGDPIADPKTKPPRKSLTPVEIEAHPGVMIDEPICQLYSPELVTKKVPSTDHSIPPPRTLREMLCWISDLPHALGYADLINHLANSFEGSESIDVSPESISSEDVTEALSETCGHASSVLAGIQEPVPIDLNKLHYERYGAPLMYYSEDPYTLLCQLLSYVYATYHQLSFLRTQCRRESHQGGWRDCQYGKNVKASYSRQCTEDPLDPMKLQGHGCNPSPLQGFLTDQSDLSTYWYQRNDVCRRSRIKMGFVAKNFRNDSKHGFYIYNFLTGACYQNHDPLEKLCRYLVCLTKRTPRTTGELVSFFHHFGNSLHDVYSNELLSLGSSLTRSHADCPDWDHLKNSDLQAVKGIRGSESLNVISKNNHNHNHDKEHPRTLSMLLGCSDDHKNCPPHCSPITYRAYALYSHAFAHTYLSWTVYLPDRLLESLEKLHYELKKHVSIKCSSLHSCPDVLPLLYTHGFTPPEVGSQVSLTCSDVICELKDVITGKPIASLMTAMDDFLYNIREPFIFTLVALWSTALLIFANTMLYRLDVLHIRSHLIRTKASHHIDVKALLTKGRKMLSLYKDVDYFDEDPIGQLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEJ6</accession>
    <name>A0A061DEJ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition motif domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0312980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769581.1">
        <property type="nucleotide sequence ID" value="XM_012914127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEJ6"/>
    <dbReference type="STRING" id="5866.A0A061DEJ6"/>
    <dbReference type="GeneID" id="24565936"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312980"/>
    <dbReference type="OMA" id="KKATHEP"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="355" mass="38127" checksum="CE7BC380756FD564" modified="2014-09-03" version="1">MAKTPAAKKKAPKASEGKSGAKKTKKAAGKSESAVPEGVRKLRALLDQASKSAPVANAASTAEQLPPSSESSAASAPQGESAGKAKTGRRADEPGARKPKGAARPIKKKSKGGPKEYVDHPNVVFVGNVPLSVDKSELIKSLGIDPKIVKSVHFRSLPVESKFAYNKRIGVIRGKLSDAKPSQNAYVTLVDEKYVDELVAKNTMELRGHYLFINKSSPSSFSKFNRKKTVFVGRLPPNTTENELFEVFSNVSQVQGVRIIRDPVTSESKGFGFVLFDSRTAVPEAVEAFNNYSFKGYTLHVTKALDHEAASEHKAKSSKKKAPAGKKGAKHAGANKGGKPAQKRTLKAKPKNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEM3</accession>
    <name>A0A061DEM3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0400220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769716.1">
        <property type="nucleotide sequence ID" value="XM_012914262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEM3"/>
    <dbReference type="STRING" id="5866.A0A061DEM3"/>
    <dbReference type="GeneID" id="24566071"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400220"/>
    <dbReference type="OMA" id="GHNSAIG"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SEP" evidence="9">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="129"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="204" mass="22298" checksum="614F645D9CE12C8E" modified="2014-09-03" version="1">MSNIKSFGDYVEDRREQAYSYAGGHNSALGVEDGHTVHLYAGGFTVDEGPFRPLSEPENALFLSAVRNGVAPPELREHGKDAHVYLIDDSHLTYNPPESHTNEPSTTKTTGTAISVQDIRIGTNSGNVTTLRIKLCDHRQINLKVSPETTIGELRSIISAKSGLSVSSFRLMYGFPPRELIANDSDTLNGKDLLGCAIFQHMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEM9</accession>
    <name>A0A061DEM9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0400520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769746.1">
        <property type="nucleotide sequence ID" value="XM_012914292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEM9"/>
    <dbReference type="GeneID" id="24566101"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400520"/>
    <dbReference type="OMA" id="WRRETCI"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596086" description="tRNA(Ile)-lysidine synthetase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="284"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="726" mass="81806" checksum="7D4001FEBEDD53DF" modified="2014-09-03" version="1">MSSAMRSWTWIVQSVICLVALCAHKSFAYRVTGVSNSLNLSIRNPTELRSSLTENADLGDSFSSKYLVVQPPLKVLWETISEYVVPLCHSKSDDGKAKPVPVLLSCSGGQDSMAMLHALGLIKQHAGSFVRSSPWGRIFGEKGAVDYELIHITLRKLLANLHVVYFDHRVRDDTSKDIDVIRSACSEYGFNFIVEVATAPIVALGNGESSGNFQRTARKWRRDAYKRLISELPVMELAQASGYGYADGAENAQVFDRNVLTRESDSLLDKHADRAHFHKGIRGVVLLAHHANDNVETFVFKLLRGVHVSNLSGIERVCYLDEDKDIVIARPFLRLSKAELRSFLENVGGKYCEDSSNASTKYQRNRIRQSVVPELLKATSNDSNVDTSLKGLDKRFRTVSAQSRGVKQFLDFETYMFSKYVSAKYNLPNCVAPPQEPHYGVSGHSGANLSRLEEAYSTFYDRMYAATYGNTVCEKTRKYMRSLQFLRNLGFNTMEVLLLREWLLVQSELTRQDILYKFIQRASGTDFQLDYTLLERISMAWYENPVSETPKVHSLRGDRAICHQGSMIKICRPTSSEIPAHGCEVYDDGRCSFRVFDNFNARIGPYHHMDLGTGFHLRLSIPHEGEGGRPAAYDIRQLRDDDIVPCDTLWNRKAASVLAKMNFPHILKDELPVLTVRDSSQVICFYGVNILAPYYVNAPQHVTVSFGKKAAASRGLTDYYIRITGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEP1</accession>
    <name>A0A061DEP1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0401120</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769806.1">
        <property type="nucleotide sequence ID" value="XM_012914352.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DEP1"/>
    <dbReference type="GeneID" id="24566161"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401120"/>
    <dbReference type="OMA" id="GRNLLQH"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="14">
        <location>
            <begin position="271"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="13">
        <location>
            <begin position="578"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR97620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1322" mass="150081" checksum="608C42EC1DE974C5" modified="2014-09-03" version="1">MRGTIGMGMGMGMAPGFAMSYPRPPVPQHFQYHQQYSTAAKEFYEPRPQTPMEEQRSVDAPQSMIVEPTPPSQDLSEGIDMDKVLQEADMMSQEPAEVLDESIVADFGEVDADVVDVSTTSPNEKVASELETALPKDSKDVAFYILDVHEDLGGLLRLFGKLHSGGGRTESAMVTVRQFMRCLFFKARMDLDLSDMPEAENSYERAFMKRFFAEFEPIRKSYGIKKVKYKLVKRTLLRYGPSEPALYVKVCYPFSHPQLRNEHYQGTTYSDVYGATTTPAELFLVKRKIKGPSWLRIIDAQRSSENVSTCKHELDVETHKNVELWNARESENLPTPTLCVASVSVKTFFASQTNQEVLQIAMIYDNVFPVDASEIKSLNRCNQYVGIRKINKQPWPTEMSAFLAKRPYFRIFEQERGLLANFMKTLEVIDPDVVVGHDITQNVGEVLLKRCNLLNIPLRVSFSRLRLLRKAPHPFFAGRIFCDTRVLTKELHHNRSNYDLSSCVSDLVYSSQVKDHSFYTKNSFNITELSPCFGEDSMKNLLVLAQANSKCCLDSFNLLIKLQALQLTKELTNIAGNLWSRSVQCARSERNDFLLLHEFHRAKYIIDHNFEKYHKHSSTTADNEEDEGDKKKKTYEGGLVLEPVTGLYDNFILLLDFNSLYPSIIQEFNVCFTTVKLNEDESVEVVSDVGGMLPQILRRLVELRASVKAAIAAEKNETRKSQLGVRQLALKLVANSLYGCLGSVYSRFHARHMAAYITQQGRMVLQATREKVEKQFALRVIYGDTDSLMIDTNIRDDGSESAFEAAHQIAGTLMATINKSHKKLEIGMDAIFSRLLLLKKKKYAALKVVDYKNKKFAREIKGLDFIRRDWSILTKEVGNALIAIILSDKHNENKEQGVENTVEKIHDTLKEVNKSIVEGQIPPKAWVITRQLAKNPEEYAANSNLPHVTVALRLNASGASFAAGHEVPFIICSKESIERYMKSQNAEEGEGAESLDAKLRSLCNRAYSLTEFQQKQLEADIQYYKTQQLLPPIMRLCGVIEGTDPQKLASCLQIEDSVSRTILNTNYSSFDYGEHESKAMSLINKSEERYKEVEMTTSVPCQFCNTAVHANYFLKHMSCSNCGNWLPLHAMRNWITRTIYEISMQSSFCIRICNICNTTTPSVCIGDNDVCPQPTCQSRDAMEVVLPASKIYLYYEYLIFMTEGALKNEAGGEREETLVNVTVDVNGKMTVLNTQNPFRKVRAFRDILERTVQLSNLRATSGFRVCGQYILGILEALPFMQYHTVDYRAERAELCKLVKQLQKRNAYSVVNLGEVFRTLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEU2</accession>
    <name>A0A061DEU2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0403630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770061.1">
        <property type="nucleotide sequence ID" value="XM_012914607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEU2"/>
    <dbReference type="STRING" id="5866.A0A061DEU2"/>
    <dbReference type="GeneID" id="24566416"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403630"/>
    <dbReference type="OMA" id="VIWIANK"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048422">
        <property type="entry name" value="NOA1/YqeH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21516">
        <property type="entry name" value="YqeH-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="341"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="NOA1/YqeH-like C-terminal" evidence="2">
        <location>
            <begin position="463"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="600" mass="66422" checksum="3F02DAF80A736893" modified="2014-09-03" version="1">MRCLQLCKLIGNLPTVQQRLLPPERRWKRIHRRTTHIQLLSTAIGRPQRSRHIATEVQKQSLNDFGLDNDTDTFLPGITVDPFFKELNLPKRCIGCGALFQSADASKPGYVDAGILSDFGARGAAKVPRVGGVEVERVPDGVQVDKCDDGRFQRLKRRAVCRRCYRLQRVDLQCEVDSHRQSAAGVSDSRMSTERIVTATPSNAGGVLQMPEEAERRRTSASARITTAPEVISNMTRRLKSDGVVLYLVDITNVEATALPELYIAIRNKAMEVIWIANKVDVLPHRTDLPEVKRWLRSMVRHIGNAKNSDVFMVSSTKGTGFDALERRLKEFIKVGDARPIYIVGAVNVGKSTFVNRFLSYISYGDAGTLQMKRGIGGATRSVIPGTTLEFIEFGLFGGFKLIDTPGIPVAATVTQLLRRPVDMVAVALNKTMDTPTVRLDAGQSLLVGAMARIDLVEGSAASVRCYIGSGVTLHVCRSVAAADVMRNKAGNAIFPPHTKDDYELLGPMKKYRLTVNCNGAIPVDDIVIPGLGWLSPTGVGPKVIEIYAPKGLDVLRRPAMIRQQPKRVQKPYVLRRRGKLKKLMKMRREIVEKNVHRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYX1</accession>
    <name>A0A061CYX1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765982.1">
        <property type="nucleotide sequence ID" value="XM_012910528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYX1"/>
    <dbReference type="GeneID" id="24562337"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101250"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7269" checksum="4C90046DC702D5C6" modified="2014-09-03" version="1">MQYLKGESSACTSFRQKGYILKVQIAIEDELPSDNMPMSCYVLHLTGANHLRNWYAPSYTKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ40</accession>
    <name>A0A061CZ40_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0102200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766077.1">
        <property type="nucleotide sequence ID" value="XM_012910623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ40"/>
    <dbReference type="STRING" id="5866.A0A061CZ40"/>
    <dbReference type="GeneID" id="24562432"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102200"/>
    <dbReference type="OMA" id="CEFVELK"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="129"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="413"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR93891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="709" mass="78523" checksum="CE5E02D0318403F9" modified="2014-09-03" version="1">MVGRYTVICGVVLALICAVVPWFVSGTGRAWYNVQHGLASGGFGTARSARSSRHNALAFLPRSPKQPERKYAYENTSYKQRNVRRNIYEVDAPASKEHAIAFFSHVLQATANPAFAPVEAPVGSFLTLTKQVSTLGPATSDAASLKSLIDAGTDIFRLNFAHGTRTSKLKNARIVRQLELTDAPDGVKSSGSFLFRARALLGDIQGPKLRIGRFMPNVDAKGVGLKSAEAEFVTLKKGDLFSFDTADVKGGRTRVQFNFPDILRQLEVGNVISLDDGNISMRVVDVNKQEPSVQTEVLNDGVLSSRKGFAVPNVVLPVDLFSAKDVKDAVFCYTAGLDFLGVSFVQRMQDILYLKNILLDFAESPFFQALRERMDTLDANTLNTDEEDPELEAILEQYYTERFLPNKQSLLTKVPKQEDAGIGIIPKIEKQPALDDINGILEVSDGLMIARGDLGVETEITNLPIIQKRLVQLCRLVYRKPVIVATQMLESMRTNPKPTRAETTDCANAVYDGADAVMLSAESATGQYPAHTVEVQRRILYNTERDPYFSTLQVTREMLLHDQMLTNLKGVRAKDAESADSLLQLDLKFAKDWNTRHGDVLAACEQVSNAILTEGVDALFVHAEDRGELVQWVATKRYTIPIILLTRNVELARRLQLTWSVKAHLLPSGANPFTFAQELSPSYVQPKRKVLMVETHDNAVDTSIVFEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ78</accession>
    <name>A0A061CZ78_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765924.1">
        <property type="nucleotide sequence ID" value="XM_012910470.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061CZ78"/>
    <dbReference type="GeneID" id="24562279"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100670"/>
    <dbReference type="OMA" id="NHNIKAY"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266:SF17">
        <property type="entry name" value="BRWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="1908"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="785"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1263"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1416"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2028"/>
            <end position="2056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2085"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1286"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1297"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1307"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1344"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2031"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2139"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2171"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2185"/>
            <end position="2209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2221" mass="244281" checksum="81F6BB3100910A6D" modified="2014-09-03" version="1">MKRQRSPQINRPYAAVLDGLDGVLRRYHHSVKTWHAEGSVCAQRDAATDVSSTQKGFGANVGASFDEEAAPSPESATSRVMEASNALPDLLGGILYDFGRVMQRESSRFDAFDVLYRAVAKVRDREAAVKAVKHRRRSAVPPVNVYHQLLARRMGRGSAVSALGDRPYRKVAKRFKRAANVWGHHCCLDEIDPSKPYNEPPQVRCIRFDRTGDVLITGGDEGIIKLWHTFNCTLITSLRKHAGGVVSMDVHPNNYFILSCCDGGEMWLWEINGNLYRPHKRVSSPFKYLWCRFASFGGSVGGVATGFSDRCEREIDSTLVVCVTTDSRLSVYRMRDLVVSSSGNNVVREVAPLYVVELFNHNIKAYDVSRPLMHDHSFLIAIGIEPMFLEELRLADDAASSALSILQGEAASRSADRAQGQYGKITSNALCALFNISTGSFLASFGDSAAANSASGMDLDTTAPSVPERRSSVPEGEVGTEFCVCDVSMDAFLDVAGRCRCCLKPVRTFTFREVPRSSPRDCLAHSEESSPNARGSKADAGPFSRPSAPHFCWKVDANELETYIRRELEGYAIHEESQVAASVRFGTNSMPFGRLTSTVVFPSYMDTPYLLFDALDAEQRDTGNFDDLIYHVQRGHELSPDVCFANHSLNHVTGSDDGKVFLWVHCGSTVKFRSTPLPTRCINRWVCNDSSETAPCRQAPAIFDPAFIAEPPVTVAECAADAPIGLFPDTAFSSTQEGADVGRGSTFAPMDVDIAKSEDTSMQNTDLATEAVDTSANVTELDLTVINSGTSEPAPPSSRDDASEKGKRHGHGAASLASGHLPKDGDSNAVAEMEVEECHDYCRPPWLTDLTSEDLDVCDTFLASDRVKPSMREKEVYQSRNAPSKLFKEGDSSKQHMSESGHHYMVTAIAWSVNDEYIFIADSIVTRFNVKKLITASRTILSGVSVFTSQGIPVADFLHNEISHHVGCVKPHPLTDDLALVITYGGVIYVLSVESKSVVRKLDCGPNAVWLDADWHPGGMYFAACQSFGCFSLFTVDGLLSNYRATLNNQCGYSDMLPINTSAFYSGAENESVDMRRYHYGSNLMPPLELDGKGCSESLRFYTASSVHTVLDDNHCEVLYACSPVAMQVDDTKLWRNRLLDMSVVPAHLWLPISVLSRIPLDINVVEFLQWHFGVYGKCDVPELIAWFLCVNKLDVLGNFTNRVRRVVCPYGGVTCVACQHIITSSDRAERYAELSVEQHGAKSKVNERGDIIACLPIALRPQSSTAPHPPAAPIERRPQAVSPLNRANAAATTTRYNQGSRAQVVSRSSEGGRSGSGTRHTSSSRLPPTRVQPPRGAAARPSTGASSTTAQTFTDAAHTRASPRRTAAPVATSPAPGSPKETPASNRATSQMQMGLAEIDRALARVTSDERTVRRLRREMRVNQSSDDESPTDRVSSSYSFRNRRQCVEGGVKRELERATYLDGVLGPIGLSKAAHQASSPLDAVCLLCGFGSDSSKSKRNTGVKVYIGGSTLVRNTLIGPFAVSKRYMDMMEQEFPKLFDRMGNEVFMHVGCLAAATNLVLDSSGHKIANLLEVLIRGMHDKCAYCGGSSATLHCSGTDCNRAFHYPCSITCAEDEAYQRQQPTSRRNPSFWSRMNNPVDPLLCDRFLCLECTLKDWIDGSPSVEPLCTGEHFLSDEPRAWFYSDARDMYPNCYVPQGGDLIFIPLQARSSIKANSAIPWSSALHTHILEVKKIDYRFCGPISGDIGICSVLWVRQMDNNKRQSLFYRPGDLTVLTLVDVLVGVWRLDKVNVGDSVKVLCADGWKDATVSGIKDPLVCSANYNLVSGDFSTANVSRLGRAAIDLGTNCIQAKLVSDSSEQWYSAWQFRIDPASESSLSDELHQRLFPAEAKEELINLTLDGSFEEFNILPNWAECDESWVRTYWSTVACPMSMEKVRQRILNSYYMCPQGCLSDLEVIVRNCRFFNPPSSVLCQVAQTLERAISTTRDEIRRVMNAEKYAKLLIQHLRPFLDRLFVAPSASDHEVVGQDSITPTQPDSMSQSQPFDADVSPASTFGAISPTQAADCFDDDDMPIRRSARLLRSRASVSDDIQAHRPPQASTAPLRSEIQEETGDSLGSESRQISSREDAGSVIRHIGTSSSSRRSSVPSGSTQVQHPDSGRPTAAGELQATNRRTSSRLAAISEREAEQAKNAALERQRQEEEEKLRRTSASRYNLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZC0</accession>
    <name>A0A061CZC0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0102940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766157.1">
        <property type="nucleotide sequence ID" value="XM_012910703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZC0"/>
    <dbReference type="STRING" id="5866.A0A061CZC0"/>
    <dbReference type="GeneID" id="24562512"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102940"/>
    <dbReference type="OMA" id="AHEVETW"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36962" checksum="87F5C6ECE9C041F8" modified="2014-09-03" version="1">MASNASVNVIHTLHTKGQPDCIKLFPSDILQDDTLTGTCLAATYDYRPETKSREGSLLAFNPWCAVHQYVPLAFEIRLNRLLQNDVKQDGSIAAYSVTEQRSHGILSCSWIKLPDHHGASCVTSNLTIETFKVEANNRNNDDSPMLSMERLGEIQLDNKNDVDGFMAQKWCGSLLKAHEVETWISTFQPDNSNVLLTGADDSQIKLFDRRIATEPLQTLKCFDRHLMRFDMRNMKSPISVWQTDGAVWYIDFVDWNKLHVAGCYDGALVYASEETGEAQPLSATSCELKKRFAPDNALIYGASHYELPSGNVYISCNFYEKQILFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D061</accession>
    <name>A0A061D061_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">T-cell immunomodulatory protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0105300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766407.1">
        <property type="nucleotide sequence ID" value="XM_012910953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D061"/>
    <dbReference type="STRING" id="5866.A0A061D061"/>
    <dbReference type="GeneID" id="24562762"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105300"/>
    <dbReference type="OMA" id="PGDWIPW"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595832" evidence="9">
        <location>
            <begin position="22"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="512"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="659" mass="73695" checksum="62557EAF58D903A7" modified="2014-09-03" version="1">MSRNIINCVFLLHTFVWLVLGYDIKQIPNTFVYNGQIADFGDFDGNGQLDAITYHQKGNDATICVFKVSNRSDKPVILATAHLQGNVAGAVGVDINLDSALDVLVIIEESKHKYRLLTFYQEKKSGLLVQGWDSTKETNGHNQKKEQSNDRDSQLGTLMKRGEYEYSSIHPLVLDINGDGFVDLFCQTEDKRLFVWTNYGGAFLPYLLENVPSCYFEGTREGYVPSPHSSAFVDINGDCRADLILLVQHENKRYLQIWETEADNNRMKYIRNPNKDIVLPTNHGQVSFADFNGDGTIDIVVPYCNQLNAERSCIQGSRIFITFNHQKPFCSYIWNNPNSDMCRKATELCTKSDFAFHPVDGLSSVDISLPVNVGFKDSEGQLMSVSLGDLNNNGYPDVIVLGWNLATLQPVVCVYRNVENNESSVVNARSFVQSAIIEVTEPDIRYIRVAAVDLFEDGITEVGIFTSKVSIGNDSIARFYTTVNEKIGLFMKAMVRGVAENETPSSVNVLSTGSNVNGAVFKITVIDVYGAKSPRCSTIRPQSAHSPLLPPYSMFGLGKTNNYVEEFYLGMPSTSKSYSNMWISIIPNCSVIAIPHRLLYPNEWTLKLSLSPSKDIYKILVATLICLVSLGVIIVGFDIKEKREDSEQEKGFRQKFIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0K6</accession>
    <name>A0A061D0K6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766512.1">
        <property type="nucleotide sequence ID" value="XM_012911058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0K6"/>
    <dbReference type="GeneID" id="24562867"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106350"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="78" mass="8713" checksum="1B8BC4ED2562FEA2" modified="2014-09-03" version="1">MATSYHPNRCAATVVRYRRQFYVDIRASIAGCILLAAATGLLYIKSLSAQTRSDRPPRRHNPATHHGSSESQYTLSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0R5</accession>
    <name>A0A061D0R5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765913.1">
        <property type="nucleotide sequence ID" value="XM_012910459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562268"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100560"/>
    <dbReference type="OrthoDB" id="365924at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1886"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="1912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2089" mass="228253" checksum="C488960A64D18FC8" modified="2014-09-03" version="1">MAQMQHIPRSEAEGGRPARGTHPGSAVAETDPPEATHSAPDYGYEAVSKLVTLYGVDSTGLADFYRHDKTAFAKAVVDRFHRRDRSKGLLLDTRNSPLVDVTSYFTLGEVLDSDEACGTAASPSTTDVAEVTRLTTHSPSHDKLIHEVVADYGSDGGVLPLPEVADVGESPQGDVALSEAPPQEREQAPSTAAEDIAASTAAEDFAANHVDSEDVAASSEDPPSLPEEAGASTEPEIDASNDTNYQDAMGADACQSQPQPASGEQNRMLPTAAMLWAETSELDEVERQDPHNTPVDAHIKIGMKESLDWIEDTVSLRSESQPSHALQEAEVDEPHAETICTPGKSEHCHEVSSSIADPSLPLDCETTSIGDVMPPDGVAVNASDSLFHGHDERPVAVHAVDEPLVGNDTEEMRTGEEGAMVSEDTVLQQCEINVDTETSTNDYLVSEDVHQVDSENAEDNVYKTDGNLDNRSEPIGEAEDSQENHDLPTIANGEADIQDVVMLDDSAAVADSEQPQTVITQDIEQDAPGESAESQPDLPVKTEADESMAQDPMLDSSESGNEVFNEIQGVTNHEYSNEVDFYNETDADTVMKVTHEEEEGTQQPADADDDTGYCAVTQCQIDIAPSTVDKDALSPVRNDETMVTDMVDSSDTFVENRHRVTEILRTLDLKQVENLRQSVENAMQLASESCGIEGAHLAFVLLLFLEMGQREPVRLSLFVTLTARTLATVADRDWDAIDSEILHMLVGALPPLISKELPFEVARPLMDVCVELAFKTPSHLAGILTSLRTHMIVVASRCTNMEEYSALLNMVVTRVDAGASHSRLITTLLLRLFELMLSGVHMSNAFHDCRNAVQTLVDTSLSANFAFLKALVESLIAAPNEIAGHFMLLFIAQLMMECARDPKSSVLQKRRCLRVLQTISGYVFSVLNAVEESCGFLPEYVSCFKCMSTPLFKISVFDLNLLEGCGDGHAASDPRHFDAQALHEVAERYMTHLGVHALREGSTSDLVLLMSLKHIARVNSAGEILTSRPLKRRMESRPSGAVGSTSLSPEHAGDLKRLKCTDDMPSSAMSESVALSPDDPPCATQTDSQSHEEVAESVDDTEDDEEPSSIVDAADAIGATNNRDEGFLNLSPSIGEFDVAVQERLTTHDTLDHGLDNHDDRLLRFARIVYRLFKATRGHRLDGPMDAQLGQYFLLPPQRLLHLEDASEAGLCFKVVLYHIYNELYLGIWRTMTNVLYTTNEYSQLSSASSFLYEVVTRRFDYLRYHVVRKLLVACMGDQCYMVRLTASRLMCEFFSRPPDSAEGIGDQLMGRVLLSMRDVNWKVRLAACKAVFQYVRRQGVDMGVMPAISAVAERTCDLEREQPPVRDMVLNTLAYSLFSTANPLLKSTGRMDEGTVALAERFVKVILYKMCAFKARENYVQRVLEHYKSHITDVESSSDTGFLRGLAKHELHEAVANHAKSALEKWMSLLLDLFLLRRSDGASFHVLAEVLCVLKLFGQVCPELFASYLTYFLPYLSCDSEETFDASRMEVVVLVCNLVAIASGYSNDLRKVESNVVQLLSFDAPALTRAAIQLLVALGSAHHITAVFEEAFTYLSNLQSVLGAEHMAPEDIVRVMSYNVLLRSAWKLGCVAEFADLSMELSGGKSRAQGLFDVLLSLIEVFYGAGLYNVAGMLVQSVARMFINLRNIVCIEFKGVKRVARMFNNENMTACVMMLLYQLLTAYGRLASPSEPDSAVASADALRTAHNEVFCCLGGFVEGFVALLAVDNNVARSLSVCGGADPVMILEICNMVLVNRLTNPEAVIPFVFCHIVSQELNSQRLAEQALKTLARNDPDIFLCRLASCLQSLLLCVIIDSFAVSLRAPPRPVTPRSSAELCGNAAGEHKTGGGGGAADGAVTPTAAGEVSPAGASSGSGKGQNRGFILGYESEHTTARVRGIVRLFVEALAAAKHAKRVVIALVAQLSVCFSPDFRQAVSAAVDSQHIPAEALHGLRASSGARLPRQLMKHIGRARKGDPEGIVHYFILLYVDLLATVLDHLTFRDASIARFLLKRVAECDKTAAMTGPEDIRRYRDARLTALSSRIRQFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D110</accession>
    <name>A0A061D110_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765978.1">
        <property type="nucleotide sequence ID" value="XM_012910524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D110"/>
    <dbReference type="GeneID" id="24562333"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101210"/>
    <dbReference type="OMA" id="NEIKHNK"/>
    <dbReference type="OrthoDB" id="361479at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="610" mass="68260" checksum="9288CB1942EB99DE" modified="2014-09-03" version="1">MPLKLKEAVTLFISVRRGLEGGLLNEIKRNSHLNVIERIHFKRQDIVPDVDPSINEGEGRIINAPVDLAGSRIRSSDENKWLYIQNVAEEPTTVRPKAVAPPHCGTKLTETCTLRLQSGGVEVKCNREWLIKCVLGLRAAESVWLRVGSPFRCHNSEQLVQRASALPWGEYLPNVNVESICIRVISRHSTVWSKHVIEEAVRQGIQSHFACNPVLKVRSAKKFGEICVSVTLNRNTCYVAVQCSSRLSPREYNFANATQQLSRLVGESAVPFWSLSKTRLQARLEASSISEGKGFRVAPVECPQQDGRDADHIKAIRREDYIQQQHILQGDKYDTADALVAGFLQTGSVFKALSSRPLQIWNPFCSNGLVTSEIVGLILQLPNFTQHNTPRALFRLLSAGNAADVYDDTIVEYLGGKKREARGVHIIASDTSLLKLSQTAEKLNKLHAFYEDLLDGMRNRTCTNFSAGDSEGSAITDQPTLYRNYRNRLPIQLSLHHAPLGVVAPLMYRPLVIAKIPSVRNRAYKERVYDTIREYKAFGHIIGSRSDWRGVFAIAKGTAFEHFSGLEWHCVAKATNSTGDVIKLLRWSGKSQKLGDPQDRLEQIHALDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1L6</accession>
    <name>A0A061D1L6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0103350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766203.1">
        <property type="nucleotide sequence ID" value="XM_012910749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1L6"/>
    <dbReference type="STRING" id="5866.A0A061D1L6"/>
    <dbReference type="GeneID" id="24562558"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103350"/>
    <dbReference type="OMA" id="LYVHPCG"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="431" mass="47348" checksum="1FADE3FFA2BC552A" modified="2014-09-03" version="1">MDSEKLLFYEALLQQLHDDDLEDAAASIKQKLKIEPNGLLRRNHLFDLFRNNAYLSSRVVAAAGGSDVQTAENAYELRLQDVLDEAHQSSAPQDKPYRLTGFAPFCDFPTYRPCRCVAESHDGSLMATAGAGGALHVIPTMPANGEAIRRKPNWQNTTRLQGHQEQIDAIDFHPRRNIIASGGAGCNILIHDVSIANGFVHSVTDIQRLSDSSQIRCLRFHPCGDFLVVGTSSPVVRLYDITTRACYTSNQSRRQHQGGSINGCDVLHTGGLIFTAGDDGSILMWDGKNLDVLRTMEGVHGGSPVLSVRCEKYGRYLTSSGQDGTTKVTDLRMMRELTSVGRVSRGVMRASSDFMFNSRFVTTFSVVQTGRRVTNEVLVYCVDTGSQEADISSIMGRAAVFDVLASKHDMALYLLIDDSSCKVISFFEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Y7</accession>
    <name>A0A061D1Y7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766323.1">
        <property type="nucleotide sequence ID" value="XM_012910869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Y7"/>
    <dbReference type="GeneID" id="24562678"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104460"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="36525" checksum="FC02A25562EA7A09" modified="2014-09-03" version="1">MVYTSLTDIPRNLKEGIDWLLAVKGADAEKNLAAMGAALYDFLVDKPVGFTEVPALENVKLISKEFLERQEFKDMWPANELLGRFNNHVKTQNIDHLKYPFPINDSDFSNVVRARRAVPEKIAEDLGRIVDGCESFLEHIVLPEQYLSAYNSEATWKKSCSEKPEDCAVVLVGIAPMLYAGLRSLKVACDNERLGGVPGAKAMSSLGSVLLADGYQEKQWPTAMTPSYVAKALEGVSHEVLVTLYDFAGFWAFYGLHDPNNVPAVKSGELDKDAQEFIDFYVNMKPINPPKKKLQFIKSPSTYTATGSNNMYYPWLPTVLDMGDTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D232</accession>
    <name>A0A061D232_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766363.1">
        <property type="nucleotide sequence ID" value="XM_012910909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D232"/>
    <dbReference type="GeneID" id="24562718"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104860"/>
    <dbReference type="OMA" id="LMRAQCY"/>
    <dbReference type="OrthoDB" id="363620at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="964" mass="110454" checksum="34B2943F9115C8B7" modified="2014-09-03" version="1">MDFYISSLAARIPCTRLHRQVQDPRGRPVAAFAISRDGRLAAMATYPREYRSVERSVNVLFKDGKALRTSNYHKAVQRQRRLTEQHHELEYNVEQYIRHSLQMDTFGSLVEEVAMSTPSLSAIIRDNNPEPAPEPRPIVPCAVVIYDTMYFNPVEEFVYGYKLNDAVYMKNSATNTPSAGVVEPSAHLPPHIASAISSKCLFRPTKMSFVCNDSVLVISSPDDGAKLFSMDTEYVELLCHFRPQLRDDVNMESLKILTVNVVMADLTDHCSELPSVFVSPYVFCHACQQAVLKDVEACQGDAVPYTVVIECVLSLSSHPPLRMVLHSRWPSGDVAVHSVHQMYPYVEQLSAPVDYVVSVFRARLTDTEEFDIMNRVHTYWAMEPYMHDKTEFLIHSDKPIACGYTKTLLASKVNSRDYLEDYQLIAMYTPDSQLYVMDTECNVLGQTEVHNAEEGFFTIDVDRTGSMIALIGTESIFVYRLHVSRDEDGAMSVAFQLQMKFPHVVGVGRREEILSACLGRDLGNRWMYVSVARGSVDAVMYVVDVTPSKGKDPIKRTLNMNSVIFPCITDMVALEGSILLMPRHQRFLVQLTQEHLDSTDDTYSRQFCHFPLLSTNKEALMLNSAVENCPQPAREKFEILLLERERQISSTMRTSNRLSIGRWLDALYQYNALCMYKGRGVVEGMDPHDYLLPPLRRTRQQFPFGYDAKQFYDPLLGIEFTGSPALMRAQCYEWARDVITRSGFINPLYPMEVVYDDKLQMLDYVCAKICISQWDNPADILFSMRSNDFLRLQLCNFLKISQRLELPCDAQGMIPCEKTMIFKKVSEVMPQMLVDGVQIPVRQSRASLEREAFEFIRQQLVPELVSIPANKLKKIIRDRLYRLRKKLTVLERYKQEHDLLDVRPDFTLDEIARNDCRLPTFRDSVDTREVLLSEFAMRVRIKVLTTFYKAHKDGGPDLDEFDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D284</accession>
    <name>A0A061D284_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766909.1">
        <property type="nucleotide sequence ID" value="XM_012911455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D284"/>
    <dbReference type="STRING" id="5866.A0A061D284"/>
    <dbReference type="GeneID" id="24563264"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110210"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="76229" checksum="80B3F8424BD5859E" modified="2014-09-03" version="1">MAGHGVKLDTLKDCLQFLEWLHDHKSAKYLVAHRLVRLLKDRYKTVDSSQIVEALSQFLNPVSTFHKRLCNKAETSKTIPNNNKEALNALLECIPKMLAATYFLRYNVDEAFKGLGGGNWASEPVGAVAMYAILRQPPNMYMKLASKIDEYLIAKDMSQEYGVMPGGFAADALKPDYKGEYKQGKVMTGDLIRILHKATNIQNYFLDVYSTTVLPTSGYDTPNVANALRLVRDFCWIFENVQQDDFKSHLYTREKCIDWQKLTEHCKKLKGPLGNIFTGKRFSFTGFGRDLNDLKKHNIAKKMASWFKKNLGIVKQKLEEIEPFTSKSRKQNLNNKRSVLQQYYTELSKYFTKSLFPYGFTFDGTKFEAGTTHYDDLKRHWDSAIGVLKDKKEGLDELVEILKGQQCSLKQHEKDDEESEDEHDDDVMLIDEENLPVTKTEASKPVITKSEAPKPTATKAQTAENGSAQNQGKKAEQGTPAATPKAAVTQPSSLSDSNSALPRGPDPSSGQEPGGKGSASRAAQGSDQNGPTAAGGYTTAPTVDASSGGGASGGSGDNRPQGGQSQRSDGSVTCSDGVKIQNFFKGGDQCFRQPNMPYRKPFSTQTLQNINKIGPRNYSPTASKNRTTPPTPTLSTLPAVLIPDFTLDLPVAVLVMGVITMNQVVGETYSGIGIFQVMYLQMVHQWMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2H6</accession>
    <name>A0A061D2H6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767162.1">
        <property type="nucleotide sequence ID" value="XM_012911708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2H6"/>
    <dbReference type="GeneID" id="24563517"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201330"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="305" mass="34199" checksum="B9F0E4C868775A25" modified="2014-09-03" version="1">MVYTSLTEVPHNLKEGIDWLLALKGTDGENNLKAMAGAVHHLFSKHSARYQQLPAFEKIKSVAKEFLQKPELKDDLLVKKLLSRFYTPDSRENTGFRRYWHYHYDQDGRVVGAKGATPEFIEQTLSKFIDGCAKILDDIKNPDEYKSAYSSEATWEASCAKDPETCAVVLVGIAPILYAGLQSLRTTAEFKVGPFHTHTTHRNLGDMLKALGYVDPECRNGMNGAYIHDTFRVLDNDVIHKMYDLAGFNIFYGSDIVESLPVEQPVEAAQPVVEEALVAEKSVEPVKAAKSRKPGILRKLRKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Q1</accession>
    <name>A0A061D2Q1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766533.1">
        <property type="nucleotide sequence ID" value="XM_012911079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Q1"/>
    <dbReference type="GeneID" id="24562888"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106560"/>
    <dbReference type="OrthoDB" id="10675672at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="371" mass="41437" checksum="95EF1DD7DAEC70D0" modified="2014-09-03" version="1">MAVSAAENEQTYQAVSDSTDCNSHAKHNEDGNEGMLMDISEMKATVEDKMETRESLQDISEMKATLKDMREMMASLKDISEMKATLKDMREMMASLKDMREMKEIAETIKSLVHLLQRGVLHKDVVAPCVLKTPHPDGGAGTSPSGGGQQQLCSAPPQLQHASLQAQSVKIPETCVVKKSPNLTAHQQVVYNSLIYVPRNFKEAIDWLIAVRGDDAEGNLAALGAAIYDLYVHMSGRSTEWSNLDKAIRFSIDFLEQEKLKKHLYVKMILFLLDERLRVTPNILTTTVVSEDDTKNENHYKSAYSPQATWDPLFSAHPKTSALMLELIQALGYVEPECRAGMTASYVGDALEGFEETIIFLYELAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2V5</accession>
    <name>A0A061D2V5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HISTONE RNA HAIRPIN-BINDING domain containing PROTEIN,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0202630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767292.1">
        <property type="nucleotide sequence ID" value="XM_012911838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2V5"/>
    <dbReference type="STRING" id="5866.A0A061D2V5"/>
    <dbReference type="GeneID" id="24563647"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202630"/>
    <dbReference type="OMA" id="ELSDSWH"/>
    <dbReference type="OrthoDB" id="265795at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="3">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="208" mass="23349" checksum="F9E85D1EC9DF2A4C" modified="2014-09-03" version="1">MRRAQAFRSDFAVDKGEGVGNAEARAATRLKNINLTKLHASYERYIRTVPRHLRSPALRQSWHPVTPDHRSRSSISQWNREIGAWRRRVYLWSNVADSQCGQLSEAVSKGDVDAFLSICERPPAPDTPATYAQLVDPGCTDVALAPVLYKPSWFNGQLTHAGFQTVEESEFVGRAGKVYDSSENPEFRAFYVDYIKSYTDREPPVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2X1</accession>
    <name>A0A061D2X1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767307.1">
        <property type="nucleotide sequence ID" value="XM_012911853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2X1"/>
    <dbReference type="STRING" id="5866.A0A061D2X1"/>
    <dbReference type="GeneID" id="24563662"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202780"/>
    <dbReference type="OMA" id="NTEGHWS"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="135" mass="15344" checksum="1B4D0ABBF0FEF833" modified="2014-09-03" version="1">MEVEGAIIKAAGIIVYTVDALAKEVKYLLLKASNKPFHWTPPKGNVYSTTSPDERVTPTHQAYRALRPRYKAHDRDKECVYYLGKLTDPDSKITLSHEHIDHAWVSASNINEYCDKESLCNMIAHAEEHIKGKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3M1</accession>
    <name>A0A061D3M1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0203400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767369.1">
        <property type="nucleotide sequence ID" value="XM_012911915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3M1"/>
    <dbReference type="STRING" id="5866.A0A061D3M1"/>
    <dbReference type="GeneID" id="24563724"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203400"/>
    <dbReference type="OMA" id="ARDIKHM"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="366"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="595"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR95183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="753" mass="83792" checksum="1B32F4DF9E087B0C" modified="2014-09-03" version="1">MITFGGSGAKRGLAAGASTGSVAKRPMGGLLAGREGLKAVSARPGGDSAAASQPPKVVYIPKAQREKRLEEEAKKAEDEMRQREEAIKKVRMEYIKQAESNRESERRDRHKRREIERIREGENKPKHEAGEGAQSQTNAHNLANSDLAGLNLLSLPEAEVRPRLIEKELEQIRQHYLGIRQEKKKVKKPSEKFKTVFNFEWDNSEDTSVNDNNPIYQNRPEPQLLFGRGCRAGIDVVEQRKGSNFYDELSRRRGASGTGSDSGRSVSLSVHSADRTVRSRVSKGGLDDADTRDQEAIDSHWSSKTREQMTDRDWRIVREDFDISVKGSRVPPPIRTWSESDLPWEILQAIKKAGFSSPTPIQMQAIPVGLQMRDLIGIAETGSGKTLAFVLPMITYVKSLPLLNEETARDGPYSLTMAPTRELAQQIHQETVKFSALCKTRAVLVVGGHSIEQQGFELRNGAEIIIGTPGRIKDCLDRSYTVLSQCNYVILDEADRMIDMGFEDIVNEILDCIPTSNLKDYDEDVALQEELKTKAGYRRYRITQMFSATMPPAVEKLTKKYLRSPVFVAIGDIGSGKKSITQRLEFVTEARKKQKLEDILEGLEGPIIVFVNMKKVADVVARHIVNMGYRAIALHGGKNQDIREGAIESFKSGEYDILVATDVIGRGLDVKGVTAVINFDMPKDIQTYTHRIGRTGRAGAKGLAISLVTDDDSAIFYDLKQQLITTENNVPPELEQHPATNTKPATANQPPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3N4</accession>
    <name>A0A061D3N4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran binding-like protein 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767487.1">
        <property type="nucleotide sequence ID" value="XM_012912033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3N4"/>
    <dbReference type="STRING" id="5866.A0A061D3N4"/>
    <dbReference type="GeneID" id="24563842"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204590"/>
    <dbReference type="OMA" id="NFKDSFM"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="46"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="205" mass="23841" checksum="66E85670075BFE2F" modified="2014-09-03" version="1">MCDDKKDAEVASGAAETPEQTQNEENGCEDTKTEGTSVDRRPQAEEEEEVVEGNWNTRKVEVKEIKVVTGEEDEELFWQQRSKLYRFATDTDGEQVWKERGLGESKLLRHKKTGKIRFLLRQEKTLKVVANHYVLETESLCRLRPNIGSDKIWVWTANNTYDDESKVEQMALKFGHIEHARIFKEKFEEAAKINKKIFESENSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D415</accession>
    <name>A0A061D415_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor 3a protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0206390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767667.1">
        <property type="nucleotide sequence ID" value="XM_012912213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D415"/>
    <dbReference type="STRING" id="5866.A0A061D415"/>
    <dbReference type="GeneID" id="24564022"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206390"/>
    <dbReference type="OMA" id="GPKAFQK"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="533" mass="63007" checksum="71CDB625581A7B6D" modified="2014-09-03" version="1">MTFMLERIRASQEELEYLEKAISVLMNDRRRASGIRLATIERAIKQLVEQSQSIAQKCIAYYKDEDGLRKEEIRYLAGQQEGGRAAASKDDDGQLWTNFYSNLKKIKDYYKRNEGLNVPVEPQTVNNVINDAMSKVNVDLEFTPDENYGKCVDLQEHYRRFVNLQELRNYRAKQHQQQEVFRLNKKSIPESELEANILPFNEIDYVTYLNQFDKFAEIPRYCKYRVKEYYDYLEKLMDYLVGFFQRQNPLATTDSLKKSYQDSFEAEWIADRAAHWKDHTEQMELYLKPVDRLFASKGVFQSFQNGKKYKKIAEAFSKKTSQEMEEHSKASRDHDKSLAYMEYMIQHYKEFMTSTIQKTIEFIEKRESRTSRELEASQSLALQILESVGTDKQLDIDDVSSGEEEEQPIYNPLNLPLGWDGKPIPFWLYKLHGLGQEFKCEICGNYSYWGRKAFENHFQEWRHSFGMRCLKIPNTPHFKEITKIEDAFALYEKLRNQNEKNTFKVAQEVECEDSEGNVMNARAYEDLRRQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D436</accession>
    <name>A0A061D436_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765930.1">
        <property type="nucleotide sequence ID" value="XM_012910476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D436"/>
    <dbReference type="STRING" id="5866.A0A061D436"/>
    <dbReference type="GeneID" id="24562285"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100730"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="382" mass="44543" checksum="D0A8E72D15558961" modified="2014-09-03" version="1">MTKCMFVACLTSPTESREQQHVLLRKQLIKSKMCHEVGLVNVPHNMRFTTFDDLLMCADELEKQDPIIETVLKRSETLLRGVDSAAITIHFQGRQVAIETYMSRFQWDDGRFPRYCTVAENLQTLVQLVKKLDDDVMNKASAYADLNNRRLAMKNEAENTYLYRDLTYLITPDVVEDPQDYIDTEHLTTLVVFVPISMEGEWLSSYMTLSEMVVPNSAKKINVSCSRHTMWRVLLFKSQMKHFIEECENRGYIAKQFIYSEERYRAMMEERSKLETESHRQEAFLSRIYRVAFSDIFTCWMHLKAMRAFCEAVLKFGLPINFACFAVWPTERADEDTLRKALDSLLPRRKGEKNSGSHVTNELEGETEYDSFVSFTFNVVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D450</accession>
    <name>A0A061D450_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0100830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765940.1">
        <property type="nucleotide sequence ID" value="XM_012910486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D450"/>
    <dbReference type="STRING" id="5866.A0A061D450"/>
    <dbReference type="GeneID" id="24562295"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100830"/>
    <dbReference type="OMA" id="GIIKHWD"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR93754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="322" mass="35052" checksum="862A1D8DD2D25DCE" modified="2014-09-03" version="1">MHTNGFYISNEFYVNSLDFHGTRDLLLAATISGALVLYNLNKDGSELQESWSNQTAHTKSIRKATFSKNGRDLIAVAADKRVSLLDVEGSTVKWYGRGHRAGISTFCILDNNTIATGDDDGEIRVWDTRLAKAACRSKVSEFGDSVNAMLLGKESKELLALCDDQLGCFDLKNGKVSLQGMSDNVEDEMQCMTYAKGTRKVVCGSNTGHLCIFSYGRWGDLDDRMTVHANSVETVVAFDEDTVLVGGDDGKVHVVSIHPNSALGTIDSIHRLGLDISSTDSLCINRDKSHLANIENICIVPTDVVSALIEGEELESGFFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D493</accession>
    <name>A0A061D493_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0101130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765970.1">
        <property type="nucleotide sequence ID" value="XM_012910516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D493"/>
    <dbReference type="STRING" id="5866.A0A061D493"/>
    <dbReference type="GeneID" id="24562325"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101130"/>
    <dbReference type="OMA" id="CPAMESE"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000003">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="105"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="245"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="432" mass="49833" checksum="302F97A9DC474C8F" modified="2014-09-03" version="1">MEENGKHDSSSESTSKNLDALAGSLESMHLEGEQTVEEEPKSSTKLLDILMRAFGRKTHQDKHHAFWNTQPVCKYSEEVDSDQIGAVDFNTKTENVRDAFGFGMTTQLYYLLYENYVEDDGGMLRFDYKTEFLQWALASPGYKKDWHVAVRVKSSKRLVGFISGIPVTINVLGTSMEVAEINFLCVHKQLRSKRLAPVLIREITRRVNRCGIWQAVYTAAAMIPKPITTCRYWHRTLNIRRLVDARFTSIGHRMTISRAQRLFKLPPETDGIVMRPMEPRDVDDVLELLQNYLPAYKIHPVYTREEVEHWFVPRGEVIYTYVKENSDGKVTDMLSFYRLNSSVLNNPKIDTIKAAYSYYNVATTISFKKLMEMALNFANEHEFDVFNALDLMENDAIFEELKFGPGEGSLHYYLYNWRIPSLKPSDIGLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4A5</accession>
    <name>A0A061D4A5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767594.1">
        <property type="nucleotide sequence ID" value="XM_012912140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4A5"/>
    <dbReference type="GeneID" id="24563949"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205660"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="165" mass="17508" checksum="0A0508A1F58FB92D" modified="2014-09-03" version="1">MSNHAVQPKAVKHRVAAKRKDVIADKKQSGATEPAVDAKTIAAATSVPAVKAQPAGQVKGRNKAENKKQQTGKSSVSEKVPASPRQPAEGSKRSGSGKRQRDKTVNEVDKKGPAAKRHAPTNAFSETIGSVFSRIRSSFEQMTQRVTGVSSSLLSSIMSPFSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4D8</accession>
    <name>A0A061D4D8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767103.1">
        <property type="nucleotide sequence ID" value="XM_012911649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4D8"/>
    <dbReference type="GeneID" id="24563458"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200740"/>
    <dbReference type="OrthoDB" id="10350120at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28054" checksum="C88CE501F6402461" modified="2014-09-03" version="1">MVYNSLTKAPRNLKEGIDWLIALRGTEADDNLTALAEAIHNFLVDKPVGKMKVPALEKVKRISKTFLRNPDLGNLWPINEIEARFEAPLSKHPCIIAKLLGLVDYSDYNNAVQGKRLTAKTIAERLGNAVNGCEKFLENVKIPEQYKSAYSSKATWAKSCSKKPEACAVLFVGIAPMLYAGLRSLRKASYTATRRNAPFTAHDNMGKILKALGYVEPDCFTDMNASNVSLALKGLNARAYTILYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4G8</accession>
    <name>A0A061D4G8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="9">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0206310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767659.1">
        <property type="nucleotide sequence ID" value="XM_012912205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4G8"/>
    <dbReference type="STRING" id="5866.A0A061D4G8"/>
    <dbReference type="GeneID" id="24564014"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206310"/>
    <dbReference type="OMA" id="NNMIGAC"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008774">
        <property type="entry name" value="PRK11815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907:SF1">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9 11" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="12">
        <location>
            <begin position="47"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="389" mass="43436" checksum="7D1EA60FE69883C4" modified="2014-09-03" version="1">MAASPSLSEGDARMRSELPAAVAADPRPWLQGEARRGAKHQRPLVQIAPMLDVTYFEFRQFMRLITKRAQLWSEMMPDMTVIHGERKTVDDMLHCGANEPPVVLQLGGNNAETLKEAAAIAVPYGYDEVNLNAGCPSARVSGKGCFGAALMNDARLVRDILCELRKAVTVPVTVKHRLGVDHKDSYEFLREFVTTVAESGCDHFIVHARKAWLNGINPKKNRSIPPLDHERVYRLCQEFPQLNFTLNGGVKSLNEVKEALGRGAYGVMIGRMAYDNPCELARVDTDIYGEAENPATCKTRRALLEAYADFVDATADRNADMHVCMIVKPILGTFYGEHGTRTFRQALSDMAAYEDLNFHKGKTKHAQYIHRAIEIMEVVNPDALDRNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4J2</accession>
    <name>A0A061D4J2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3'-5' exonuclease domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0101830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766040.1">
        <property type="nucleotide sequence ID" value="XM_012910586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4J2"/>
    <dbReference type="STRING" id="5866.A0A061D4J2"/>
    <dbReference type="GeneID" id="24562395"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101830"/>
    <dbReference type="OMA" id="KQQCSNW"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="3">
        <location>
            <begin position="63"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="262" mass="28897" checksum="D1C5064EE87AC2FE" modified="2014-09-03" version="1">MCRCGAGESKAAATLYVTVAAHAGARLAASCPVVDRDGALHQPQPSELKQAAFNGRIVVVDDRNVSRYVEPASDLLSSRCVGFDLEYVPDYYASALRDRSARTRPAVIQIASNDICLVYLVYKIGHLPESISSVLRDPAVLKVSHGAPSDMRLLYRHFGVQSQNFVDLQQVCQEMRLRPCSLKNVVEHVLGLRLTKKHQCSNWEAASLSQEQIQYAATDAWVTLEAFLRIKPRSVQKLLVNDHGDVEFVDSKASDGKTSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4J5</accession>
    <name>A0A061D4J5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766045.1">
        <property type="nucleotide sequence ID" value="XM_012910591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4J5"/>
    <dbReference type="GeneID" id="24562400"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101880"/>
    <dbReference type="OMA" id="CEGHIFR"/>
    <dbReference type="OrthoDB" id="365382at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="655" mass="72666" checksum="E8F1B93F4AE6B25B" modified="2014-09-03" version="1">MSLLCRIDDGRPLSGCHAISRRSIAAASEDNQVVIMHFNHAYVVQTRRQYAEVVSKIPSDARLDVKLATRNASKGALKPMDSTPEELRKEQASHPSTRFVAFAWTPAAIPVDGRLTSALCTVTINERFEMWLPKSTHSEEMYEVEKICDLSEAVASHLTNIAPRLHNKKAPANDHHSSALLHAGVSMCHFAPQHTVHGFAGLVGIGRHLVALWISTLPVEQTDDCSDDGSNGSVYSDGGPQYEAADENAEEAAESKIVRIIADSHVFNQQPDDLKRFDMVNIKCLFPTPISKTTKRRVGCHAIATMESGHVCSMAIAVNAVERHRLVYDVFVGTGDGHIRTIELRIPLDGDRIPQASAGPWRNLVAFPHPPEMLRVRVFHGNDADARLLIALVHNMAVVYNLEDGTHQRHRCGGHPLVSYHTEPLFMRGGDLASMVFLDAMGTRYFFALSADMRMRATGITPASRNDPVTVFLDETDVAHLQVAIDRPALQIRRSLRSPNLVATALDILMSGGNLLHMAALVQHHVHRREMPTTDSMFTLKNRKGDFTLDSVTMQQFLQVASTSPVLQLWREFHDLLQHPQKQRVATLLYLIAYAEAGGDASHRTAEVSLRERCRPLVRRLTRGLTLTNEGVAGLQGLAECLYTRKQLQKLINTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4L3</accession>
    <name>A0A061D4L3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766065.1">
        <property type="nucleotide sequence ID" value="XM_012910611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4L3"/>
    <dbReference type="STRING" id="5866.A0A061D4L3"/>
    <dbReference type="GeneID" id="24562420"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102080"/>
    <dbReference type="OMA" id="HNGENNA"/>
    <dbReference type="OrthoDB" id="10606186at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="777" mass="81819" checksum="6007B7CA02C4AEB0" modified="2014-09-03" version="1">MYILSSPLVASPPKLKKRLPIAFRCKDDKRILVTMAVIGYVQFSMKKKKPLNVANEVRKLCQFKEFCYLILKPQFRDALSDVEDNMIFRFSCISVTDKCYGMDCGKNAHCIHKRSEVECVCDQGSVMENGICVDKFFESAVVERDLVLQEFESGPFDIAYDSTASFEADYQYHESNSAPVSNPYAKKYADGKSAAIKSEDDDESGVVKPDEDTTVGVADDDTTVVKLDEDTTAGQAADDESGVVKPDEDTTVGVADDDTTVVKLDEDTTAGQGADDESGVVKPNEDTTVGVADDDTTVVKPDEDTTAGVADDDTTVVKPDDDTTAGQGADDESGVVKPDEDTTVGQGADDESGVVKPDEDTTAGVADDDTTVVKPDEDTTVGQGADDESGVVKPDEDTTAGQAADDESGGESAGLFGQPSSAGDIDAEGSPAGSSEVDPNLPNPQDASEGRSENNPLPNPRKSGSNAPVDGSAGSRSACNADAGTSDSTTDNTDQAPGAPHGRPVNGDEHTAADDTSGSSGSLSSPWSRHVTPRPRERRHVGMTPDGTGLPFPWPPFDSASSDPSSSSRTNQPPPPTAGSNHDAHRTDERSMRTYPSHPSSEPDEALHADGVTDGSGASSGASKWAKIIRSNHLLSAIVRLRTGVKPKVDGGAQGDASPDEESIHVSPQPLIGQGGQSSNVPTSPGISDPGALPFISSTAIPSPITHFDDSTEAGLHPRGHPSLGPWDFPHVVKDAVTTRSFKCEIPGSSRYAVLVFDAQSPQKRSLVQPAELQRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4S7</accession>
    <name>A0A061D4S7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenosylhomocysteinase(S-adenosyl-L-homocysteinehydrolase), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0207290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="5">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767759.1">
        <property type="nucleotide sequence ID" value="XM_012912305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4S7"/>
    <dbReference type="STRING" id="5866.A0A061D4S7"/>
    <dbReference type="GeneID" id="24564114"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207290"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="6">
        <location>
            <begin position="245"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="277"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="491" mass="54387" checksum="82ED72A8B3F7C055" modified="2014-09-03" version="1">MSDLWNDLTPRTEGVCKDISLKDAGKILLKLRMEESPGLNSLLEVEEKGKPLQGVRISGCLHLTGEVACLITTLNRLGATIRWSSSNPFSAHDGICAALKAYHSDNTTIFAWKGETIEEYWWCVYQSLRWPGQDGPNLIVDDGCGAYSMIKHGVDLERMHAKDGSFLNPADFDENDRDTQCLIKLLNKLVVEQGYFWEKLASQVTGLSEETTSGVTHFRNIWKKCGLLFPVMSTNDCVTKQKYDNIYGCRHSGIHGFFNGADGFLIGGKTAVVIGYGNVGKGVAQGFRGQGANVKVTEIDPICALQAAMDGYDVVLLEDVVETADIFISCTGGIDTITVEHMRRMKNNAILGNIGQGDQEIQMSELNQVPGLEIINIKPGSDYFKFPDTGKGVIILAYGRLYNLGCANGHPAFVMSASFTDQTLCLLELWRNRDNDKYGKCINRLPKILDETVARYHLKALNVKLTIPTAKQCKFLGIQPEGPYKEDTYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D510</accession>
    <name>A0A061D510_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0208070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767839.1">
        <property type="nucleotide sequence ID" value="XM_012912385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D510"/>
    <dbReference type="STRING" id="5866.A0A061D510"/>
    <dbReference type="GeneID" id="24564194"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208070"/>
    <dbReference type="OMA" id="LMECYIS"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="261"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="514"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="603" mass="68929" checksum="C73205BEBA63EB2B" modified="2014-09-03" version="1">MTEAGTGNQDDIAKDTSITSLVKNVVYLYIADCKARPDPFVPELSPKRETSAPTVFPHLRLSGVDVTDLVNFSLERVPGPKRKPLVELRKVLADADNDGIMVLVKSVCAIIGYQQLLTPEARKSFNDEHLQDWIKSHDAEAFMDKNYESVYLRWKNFLKRQTPLGTNLCDYFCGDFLKSVLIINADRVRSELEKTVFKNHPDMIITLLCKECGLTDEQAKTIGTMSSADGYQLQSLLPSETGLGFLHRDAGGAKEEDLGIISFDCITNDREPGHLIKLVTVKNIFSRQLPKMPREYIVRLVFDRNHYTFCLLKKGEVIGGICFRPYFEQRFAEIAFLAVKSTEQVKGYGTRIMNHLKEHVKKSNIEYFLTYADNFAIGYFRKQGFSQKISMPKERWFGYIKDYDGGTLMECYISPNINYLRLSDMLGKQKAIISQCIEAIKPLKVYDGLQFFKDNPGQTLSPKDIPGLVEAGWTEEPIGAASKHGSDNLAYSDDPEGGRRSLKSCILDLLNNLEKQQSSWPFRKPVKQSEAPDYYDIIKNPTDISTMKRKAKNGEYKTKVQFGEELKRMFDNCRRYNTPHTIYYKYANELQAFIWPQYESIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5K0</accession>
    <name>A0A061D5K0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0209660</name>
        <name evidence="2" type="ORF">BBBOND_0209700</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767999.1">
        <property type="nucleotide sequence ID" value="XM_012912545.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768003.1">
        <property type="nucleotide sequence ID" value="XM_012912549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5K0"/>
    <dbReference type="GeneID" id="24564354"/>
    <dbReference type="GeneID" id="24564358"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209660"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209700"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="88" mass="9953" checksum="AAACAB672F86C075" modified="2014-09-03" version="1">MDMLMLTCQHLYVQCSTKLRTLVTESRFHNHEGKAASLHPIISETVITSDAVMGSSQEGCGSDEIAEWYDYHNQLYRYLNASNASPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5K8</accession>
    <name>A0A061D5K8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">12D3 antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766430.1">
        <property type="nucleotide sequence ID" value="XM_012910976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5K8"/>
    <dbReference type="STRING" id="5866.A0A061D5K8"/>
    <dbReference type="GeneID" id="24562785"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105530"/>
    <dbReference type="OMA" id="DCPSPYA"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595814" evidence="1">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="347" mass="38340" checksum="A29FE31820DB5343" modified="2014-09-03" version="1">MLLPRSLCGLILFLLYKPASGYLYRAISMYENKGTLTADPTNVGQADVVVEKNGVGKVCKSMRSGRYIVNPYIQRCPIGTTKCGPEFDATLGTCADFSGCYTVSNNTRVCTCMSGYFGNPYVQCFKYCETDLDCPSPYAECRQGPGELFKRCKCKQGCPGDGVICKPQNICTDTQENTETHRKCLQTSTTEKSYVCDDGYYLDTYYKCVKIVAIENDKKISIVANNFVDGSRIDIGKCFSMEINKENAESRFYQMNSGDAVVVKGKIVTNPQLYLAVEVKANDVIVFAMLEDDHSKLTKLFSISNGLKGCQIDGVSKYDPTGIRVNPSQVKVEIQNLVESQGASEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5R8</accession>
    <name>A0A061D5R8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L38e, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0210510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768084.1">
        <property type="nucleotide sequence ID" value="XM_012912630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5R8"/>
    <dbReference type="STRING" id="5866.A0A061D5R8"/>
    <dbReference type="GeneID" id="24564439"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210510"/>
    <dbReference type="OMA" id="RCHRFIY"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="79" mass="8900" checksum="93D20C87CF859D66" modified="2014-09-03" version="1">MPRALKDLRDYLAVLKRPDATSVTVYRKTRKGGVQLTKFKVRCSKYLYTLSVPNQAKANKIEASIPGHIKKLVVAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Y0</accession>
    <name>A0A061D5Y0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766500.1">
        <property type="nucleotide sequence ID" value="XM_012911046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Y0"/>
    <dbReference type="GeneID" id="24562855"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106230"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="141" mass="16372" checksum="D4A4BB83A1BB7248" modified="2014-09-03" version="1">MSGRFQHVQNCIALVVVTASVFIHLLSFMQLDRSEMSENGKSRAAAPWWLNALAQRYTIKQWAAFYACFIIYYAVMWFVGTKFCYTEELDREKYSNHKTALHRLEAVQSRLKQLKTTQQYNGGSDDALPRRRRQVASGQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D607</accession>
    <name>A0A061D607_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768179.1">
        <property type="nucleotide sequence ID" value="XM_012912725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D607"/>
    <dbReference type="GeneID" id="24564534"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211400"/>
    <dbReference type="OMA" id="KPCYNNY"/>
    <dbReference type="OrthoDB" id="74703at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="207" mass="23561" checksum="7A256D9E53C37136" modified="2014-09-03" version="1">MGEDSSDDKEYDTHQLLDTDMASPTNGSSGAVNSDEDVAESEPGEPVTQDENGQSYVQEEDMQVGQYSKNRTDKDVLVAQLLCRWWYVLPDWPPKDYNYHEQLQKNMLKCYPVKEFEDRENVDSNGYRKCYQLSAFPGVFRDFKGVAYDLRPLEGKPCYNNMIQKSESELKSLIKKAIKNQIAKLSSSPHDEAALIKSLKEELTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D618</accession>
    <name>A0A061D618_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768337.1">
        <property type="nucleotide sequence ID" value="XM_012912883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564692"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300560"/>
    <dbReference type="OrthoDB" id="10516787at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1651"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="640"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="765"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1713" mass="192161" checksum="08ED62FD78639AF6" modified="2014-09-03" version="1">MTAPKKLTDCPENLREAIDWLLQVRHGNDNGLGELAKALKKFIDEAIEKAYTTNFDALLKLLNSAKSYNCCKDKVAAIEKLKDSKNLTPNTFENLKSQCEGIKNCYKSHLEDSQQKAYDEIECKLEQLDGLNKSLIGLTNGNQCKDLFENLCTGLQKFLGFNPTSKGYDGSGIVYSDLDRLCDAVMAFLHGVLESVKTYDAVTTYDEKLNEGYRLSNVLERIERSIGQGVAEFGECIKEVDTWIGRFEKEIKKKTDAFMKPLKNLKNDVLVDRNLIDYDKEHDIAYQISEWKKRAGQYIAKVGRSEKALKDIAGNLKAKLSPKISLLKQATENFLKSVRNEDLNNMFKLADEQMFAVMSYAGSKAKQRIKNLQQSLILYIRNLQSKLGKLKSEQFSNLLKSVNSGLHSSLNAANYAIDHFISTYGKDVVDGLTPIVSRALKLKDKVAAEKAVLKAQIKLMGDKLNEVNNLYTKVRIPEELVGFQGGGEWDMNTFIVQVTKQIENNIDLYVDNFGKALYKGVDMAVTLTPGHVPGLEALEGDKELKEKLGYLGSLLESAVADKNNGGLGYNIETVLKYLNDAKKVINGEWGNFSMIVGNAMKTALKGKVIAGVNDPQIFKLITNAVRTGINKLQGAVDGIITNHLNEIKRKLTELQTMDEETTTSGSLSDLQQQADDLNKAIDSFLSNTVGNTRDTKKDAKRTVFAELNYVRDQVTELGRSIADVMEKVDDVGKELTSCIGEAEALLIMAPNEAERVMETLCKEVNSKIERAFTELQDKAKDLYSERKKTEVEALEDIIEKQLRDVENLIKDDLANGVNGFLRKIKKTFIPKAYEIKSIPTTSGSKARNTAIIVQNAFTQFMSVLLMQEEVMRLEIDVSNFASSLDSLLREIYKNQHFDYVVTDKLKTLDDALTSFSAETLNDAPKYVLYPLKVGLLNFTAQLGHAYVNRYSGVKMGKLLEVKPSSKNQKPAENQLATTQPPHYDLTPEGRNCAKVCLTILEMVNDSWWKLIKACKNNSSNQINLDEGKRLGFLFYSRGYNVVTGRNKQDGELRNKDAAMTGDKIRELCEKEVTISNSNALLGVNKTGTVPIYLLLRYLNDRVDDYTRVCHLRHIGSPKAPTNVNQMLHWLSGLSHNSVYGPLCKYFKQVIPKPGKYKETPYDKIPDDELNLPATIDIKYNNLKPTLAEVCAFARRVLICILGHGHADGRYACEFSTNADGLDYPSSSSACFDTLVDVLNRLYDQLYFVYVQCYRESDDISWRDCWYGRYVGGSDWRCNEKQCPNQMGGQTCPQIANQNADQKCDQHPKCGLKSPLQSFLEDGLPGFLPHSFSKPGCKLECTVSNHRGIPCKTPMGFADISVTASRTSKGERIMKVLGAFCGQQDSPLTKLCGVFICLLQKPPQTLGDMFSFYFCYLNEWGKNSKEHKKDAFDKAVAGAYFGVSYPQLNVSSIWLTSNHAHKTHGTGDLYSLYSCDCEGKSEITCGRYMKPFGLNTWLVFSNKNANRYLSWIVYLTETFYDLLDKLYKNCCNNCNSPGTKCHGRICSASCEVKSAYESDNPSKKVEGKHHTKDCKSIAQCAFTRPTLYNYGFVLNSLTNLSGRDSVETKRTCGDFCRTLEKVISKNISDGAPLPKLIYVHIPEFLWKIREPFSYLVLALWSLSLLYLFYVLIGRLDTLHIRSHLRSLSSHKIAAQSLLAAARVGKLSKISYLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6G7</accession>
    <name>A0A061D6G7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766715.1">
        <property type="nucleotide sequence ID" value="XM_012911261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6G7"/>
    <dbReference type="STRING" id="5866.A0A061D6G7"/>
    <dbReference type="GeneID" id="24563070"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108270"/>
    <dbReference type="OMA" id="RIRTYAC"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="130"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="394" mass="44388" checksum="4250E384ACDADC46" modified="2014-09-03" version="1">MTTVETAEERKPRHAEVRSTMSHFRNKEGMLIRTYASIVSDAKGSIVLVHGNRCHYRAEFAAYNMNWYLDTFKIGEPQVDDIVAKELQAVYPRGADNLLRKASSKGEKGFDIDGQNFFDLSPRFVYEGSFINKLNELGYNVYGLDHQSHGMSEGLKGRRNYYLDLENIVDDVIQFIDIVKRGQFENTEERYTEGVIGGPSQIGKIYLAGISMGGFIVLRTAQKTAIYNQDNHMFVDGLIAFAPMCDLSSYTASLGRKIQLLVTKMLACCCPAATCMVPNDRIINNMNTFVRGQDPHFFNGKQCYGVILSLIAATKTLHKNYHLYPENLPTLVVHCDGDDTVSVKGSRELTGKILKDHKDLKYVELKGNVHCLTSVLYNENIMPHVSEWLARVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6U0</accession>
    <name>A0A061D6U0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767908.1">
        <property type="nucleotide sequence ID" value="XM_012912454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6U0"/>
    <dbReference type="GeneID" id="24564263"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208760"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="78" mass="8658" checksum="282E1968515186E4" modified="2014-09-03" version="1">MCDFDGPDGLRSGNAIVSCHMDADIMNSATVMCPRQVDGTETISNHRLIMRYHTPETEHSSHDSGIEGLKFMRLGFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D720</accession>
    <name>A0A061D720_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spherical body protein 4 SBP4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767973.1">
        <property type="nucleotide sequence ID" value="XM_012912519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D720"/>
    <dbReference type="GeneID" id="24564328"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209400"/>
    <dbReference type="OMA" id="HTHCHET"/>
    <dbReference type="OrthoDB" id="364290at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007480">
        <property type="entry name" value="DUF529"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04385">
        <property type="entry name" value="FAINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600106" evidence="1">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="277" mass="31339" checksum="0309D950AF5AEF35" modified="2014-09-03" version="1">MVAISAAFVACIFGLTAVRGFDNVIEVTFQEHGESDNMVLDLSIPSESDMMIHRQTDGCAPRTPVVYTPVRPNKLRHLVWSDTVIHGVGDDDEDTIEKVTVHTHCHETLIEVSLGSTKVHYLGRDGEFEFVSEHKYQEELREMTKTIVVDINDVNDNKYLSYETNTAYGITWYNIVPISCFYSDKVVAGNVTVWTGVGCHQRFAGASVYVNGHEKLVALIYHDVDGMKEALYHGKNEVYEELTLEQFDEQFKLLEEKFAAGKNSVDAEVRKEVEEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D741</accession>
    <name>A0A061D741_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768524.1">
        <property type="nucleotide sequence ID" value="XM_012913070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D741"/>
    <dbReference type="STRING" id="5866.A0A061D741"/>
    <dbReference type="GeneID" id="24564879"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302420"/>
    <dbReference type="OMA" id="CFNKCVP"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="9787" checksum="EE5CF86000A67BC3" modified="2014-09-03" version="1">MDVSSAFKNIKDEKEKAEILISFQKAVQSQKLTLKLLGVCFDRCVPSPGEVLTTSQQTCLWRCGQRNVETQYFILKRLEGMASNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D769</accession>
    <name>A0A061D769_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0302820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Apicoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768564.1">
        <property type="nucleotide sequence ID" value="XM_012913110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D769"/>
    <dbReference type="STRING" id="5866.A0A061D769"/>
    <dbReference type="GeneID" id="24564919"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302820"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020011">
        <property type="term" value="C:apicoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF22">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0933">Apicoplast</keyword>
    <keyword evidence="5 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="114"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="499" mass="54172" checksum="8141A9ADB405B6D7" modified="2014-09-03" version="1">MLKRYTKVLLATFSSNGYAASTASQLLSKGSLRDVAKRHVASATRAVSSLSVAADGLMASQWSCQRRLGTAASHVLASRERCSLGRLQHGDLAGHTSNPSGRRYFAVGTFVRNKDHLNIGTIGHVDHGKTTLTAALTKVCAMDGHGEYTPYEAIDRAPEERKRGITINSTHVEYETQNRHYGHVDCPGHADYVKNMISGAAQMDGAILVVSCVDGPMPQTKEHVLLAKQIGVPRLVVFLNKLDMLEDVELLELVELEIRELLSEYGYDGDATPIIKGSAMKALNSAAEEDVKPIRELLHACDTYLLTPERKSDLPLLVAVDDVLAIPGKGTVVTGRVEQGKIRCGDAIEVCGGPKSGKKTVCMGLEMFRKSLSEGIAGDQIGVLLKGVKRDEVERGFVLIQPGTYKCHSEFDADLYVLTTEEGGRKHPFVSNYRPQAFIRTGDICCSVHLLGDLEMAAPGDNVRCNIKLLHPMPVHDGLRFALREGGKTVASGLITKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7F2</accession>
    <name>A0A061D7F2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768659.1">
        <property type="nucleotide sequence ID" value="XM_012913205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7F2"/>
    <dbReference type="STRING" id="5866.A0A061D7F2"/>
    <dbReference type="GeneID" id="24565014"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303770"/>
    <dbReference type="OMA" id="VHQLNNA"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="556" mass="62459" checksum="2DA05946A846661E" modified="2014-09-03" version="1">MNDVNPYHFGSLTGLLRENYASMLDRVKGLKLLILDDATAASMSLVQTHSYLLEGGVLLTTNISDENLFNEDPQNLSNLRHLKAVYIIQPSHANVARLCDQLRGGYFKEYHLYFTSMPLEGQLEMLAKNDVLELVCGVYAYHTDLMAVCRYCFLLDAGTSDLYTSVHSGEAARVSQGLFNVFRIIKQIPSILHVAGSPEARELGLKVQSLLNNDLLNSEAILKTYSKFGTGESYGCSLLIYDRKCDCITPLMNQWSYQAMIYELLPMSRNSVRIGEEDYILNPDFDDFYGANIFKDFADVESALTEMIQDNKKTFSDAMNILQNIPQQTKICNETKRHVAILHELSQIIQSRDLLNTGLLEQDMGTHVRSSAEAFEAVVEYLNNPDLDPFEKLRLAMLFCLEYRRHEDKVNMIKDNLRMNGLESMVGKVDALLQYADVTDSGSDSLAILSRARSTLNKSLSGDSSSPYMRYTSRLAYVVQSLLKGRLDSRQFMLIPSSYDLDFSYAARPLSVVVYVVGGVTLAEYRDLQNLSAASRVPILLGGSCLLNSHSFTNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7F8</accession>
    <name>A0A061D7F8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CHY zinc finger domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0111070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766995.1">
        <property type="nucleotide sequence ID" value="XM_012911541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7F8"/>
    <dbReference type="STRING" id="5866.A0A061D7F8"/>
    <dbReference type="GeneID" id="24563350"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111070"/>
    <dbReference type="OMA" id="CHTKLAV"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="207"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="475"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="591" mass="64785" checksum="E32954AF716CBE8A" modified="2014-09-03" version="1">MSDLLPVRDDGYVELFKLQRLFGATFSDCHGGAGSGEAAAQPLPIEHAWCRGEVNAAVVLRPTDPAFPVACLGDDRAIAMRLTLRRQWPSEGASQELGAEKPACPADPGDAAPSADGGGAAPTPASCYSVNAAADIAIDNASISHELKLVIKKVMLTFVSKYRASQRYVVYECLKFLDRELARIFALYGSQQSKKEAKEPAAAASATPSSDPDTWSLQEQKSLEFALAKTKSLADPAKRWAAVASVVKTKTAEECRRRFQRCREQLLNKATEEHKSLATMPKDFETVLAKSDELRLLELELEKVSVINVVSFVAQLACTRCEALFDATFAMGDKKTAVVQRSCSNCSMAQRGEFQPQIAFGTQPVIGRMSLENCVFRAGCRRHELTALQDLINGEFYLTCEACDTQCKVRDVQNGLRKRSSCRGCFASLTLQFNTVEFGHEAPSPQAIAVKPKFVPPRAPRPKAQQARGLKVGTPLPDNGACKHYRKSFRWFRFPCCGKLFPCDGCHDEASDHPYEPAHMIVCGRCSTQQPVSNSKCRGCDRGFTASSSSYWEGGKGCRDAVKLSRKDSKKYGLMRRQANAMARDSSDRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K0</accession>
    <name>A0A061D7K0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765886.1">
        <property type="nucleotide sequence ID" value="XM_012910432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7K0"/>
    <dbReference type="STRING" id="5866.A0A061D7K0"/>
    <dbReference type="GeneID" id="24562241"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100290"/>
    <dbReference type="OMA" id="WIANTEW"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="518" mass="59864" checksum="2C43A5A62AE83009" modified="2014-09-03" version="1">MTAESEPPSAGFPEESALLRVFGDFVDPVPMVQFVGPAAYERHKYVESLLSRNKVPFGVVESAVYAECQNGTPSALMHWMWTRFVRRLVVGFCALYPKEAPRYGKLRQTEVRTCADFVRIINTFTLCPGEPVPDKDELCMAVVVQDYHELLAHEPTLLNTLMRLHEKLHRVPIEKGYRRNKVTVIMMGPYPLPPEVTRGDFCIPLVPVELITPEGAEDLIRSSSHNFALEKARTMLPDYSEATISFLWSGFVHYFVDVVYAWYKFDTSSMEFYSRLLWSNFLEPLCGATEPTGDELPERLQFLCKSVDEHLRSSTVYTRSRFITELHDLRVSNMRLLRKQLYKFHGSRLTKYLLLGAVISAFNTPETMRRRLRNKNVRTNLHDVALWRRQRKFDLWSWIANTEWALASNESESINMDPGFFTELMWLITEGYVKPQCTPETWCRLPQSHSVPLWRVSDMMPSADLQWLHTICYNEDTEIDQCLGQMVNTTARFSLSVTKGLVISIINDLNVDIDEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Y2</accession>
    <name>A0A061D7Y2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0201860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767215.1">
        <property type="nucleotide sequence ID" value="XM_012911761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Y2"/>
    <dbReference type="STRING" id="5866.A0A061D7Y2"/>
    <dbReference type="GeneID" id="24563570"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201860"/>
    <dbReference type="OMA" id="YWARRTA"/>
    <dbReference type="OrthoDB" id="193243at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070828">
        <property type="term" value="P:heterochromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000026">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR95029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="142" mass="15268" checksum="44F35085964F92EF" modified="2014-09-03" version="1">MTADEKSAVGGGRKKTVKSVTKSAKAGLQFPVGRIGRYLKNGRYAKRVGAGAPVYLAAVLEYLCAEILELAGNAARDNKKSRIIPRHIQLAIRNDEELSKFLAGITIASGGVMPNVQAVLLPKKKDGEPVQSGMDEEEHHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D808</accession>
    <name>A0A061D808_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766031.1">
        <property type="nucleotide sequence ID" value="XM_012910577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D808"/>
    <dbReference type="GeneID" id="24562386"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101740"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="9816" checksum="B0AB3EE2FA7A995C" modified="2014-09-03" version="1">MLLSPQPAESIEPPRFLSPILQSSTHGVIRLSSQQLMKLPISAYAYALAQLLVWASYCVYFYKGWILFFVASFYRALYFLGAPTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D825</accession>
    <name>A0A061D825_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766056.1">
        <property type="nucleotide sequence ID" value="XM_012910602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D825"/>
    <dbReference type="GeneID" id="24562411"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101990"/>
    <dbReference type="OMA" id="CGNINCI"/>
    <dbReference type="OrthoDB" id="408098at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="21080" checksum="C50873103AA440DF" modified="2014-09-03" version="1">MFKCRVCSIVPFASFLGLFESDDDDENKHVRKSGGSDCDSTPSAIASETPHSVAESEVERDRRSAEEVAYLVKSWDTYVHERAKAMYKTPAKRYSILASIAKGCGRADDPILGNDVACVRWYGDTEDGNPVISYSSTGDAKGKITYVTRMMVFLFADQQSYEIIDKAGCRSFKMACGNRWCINLTHISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D880</accession>
    <name>A0A061D880_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766121.1">
        <property type="nucleotide sequence ID" value="XM_012910667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D880"/>
    <dbReference type="STRING" id="5866.A0A061D880"/>
    <dbReference type="GeneID" id="24562476"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102630"/>
    <dbReference type="OMA" id="MENTKEQ"/>
    <dbReference type="OrthoDB" id="366353at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="456" mass="50940" checksum="2E47AE8A77139DB5" modified="2014-09-03" version="1">MPKHIAKTADLAKMAGKKSMSKQEGREAVGECPVHSHRKRGGRVSKQLNDAPEKPTIDLSALSSGIEDDVHDVIVDSLLTTTSAPSTTDAPKSLADAAPEFEVRLPDDGSNDVDIEPRGYVEEVTGDWFEAWSVQSLLTPPEELMRTLSVAPSKKGATTIKALEYTKERSERIIDVLKTQIAERDDSLAKMIKYVDVLEEWKNELSHGQSVLAVEQNHTLEAQMALLQEKYTTKSQECQTLKSKLQAMEQEHMLKDTELKKANKTISELSQKADALAAQIEAAMADRGTFSASLQQLKTSFKDRQNEMKLALDKDYQSQIVYLLDQIEVHKKQSERKDKKAEQMAAVLRKAEQECCKLRTTIMHLNKALEDKIEEIKRLREAMLDLEERIFKDDQNASSRISAALAAVDGARKENAELKARNRELRKELDASLVKLAMVHEKAMAATGGDFVKPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D899</accession>
    <name>A0A061D899_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768393.1">
        <property type="nucleotide sequence ID" value="XM_012912939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D899"/>
    <dbReference type="GeneID" id="24564748"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301120"/>
    <dbReference type="OMA" id="REWGTEN"/>
    <dbReference type="OrthoDB" id="365936at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="20908" checksum="A1037F6E5CC4685A" modified="2014-09-03" version="1">MKPTLRFWGRRHAGGGPVPLLRNPVKRWLHLLIFLHLVLLLLSCCTISFPFIYDLHCSILFNSLAHIIASAVGSFVMAAYYTAIAARDWGTEVEWATTAIITCSMVVVDIIISGWGIYALSNASLKIYRALYNDLELEPECLQTKAASVFVVAFAVICAHLVVAGICAVVSVLLSKGIKRQLLELRDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8E7</accession>
    <name>A0A061D8E7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRN3 domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767375.1">
        <property type="nucleotide sequence ID" value="XM_012911921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8E7"/>
    <dbReference type="STRING" id="5866.A0A061D8E7"/>
    <dbReference type="GeneID" id="24563730"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203460"/>
    <dbReference type="OMA" id="PRCVRYL"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11523">
        <property type="entry name" value="DUF3223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="940"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114344" checksum="A1F438E409B49F65" modified="2014-09-03" version="1">MATYLSHLRKLKLPRAPGSLSGAGQPSPTQDNKAIVRQLYDIVSKKSIDETALNQFLKLFSEGFCWSSATDQEVRDCRNAVVDLVVADNTLVTAVIHEFVLRFRGVSEDGAKIDLGGRVFDSLVDLKKRLRQILIDSPSGVCLEGDDLSLLLSVLRNHPRCRDAMDAVDGVFPSVHLNPKYRGLRCFFYRRKDGQCVDFSYARCADYVKPRAARYHESLCEVIIELCRLFPGVVGTVADSLEIVYPHYNLGIEQHIAVSRSMLIIARHVPPLRGVVYRLLIKKMTIIDAEIRASDPTSFCEVKLESMRSDSLKEMAEKLRSGELGVSEAKQQMEGDAWYKRMQDLRTDEDFDEMTQKLDSLMSIVLYELRDLLMANLNTVACESGASHMHSSDAGSSHVEDHALSSSDSESDSDEEVSRQGRTPSNGAVGRVKQELDDGGGPVQGPRSAADVGHAAAGAVKSEYNGNTVTTVSDIIISELFDIFEDIILPTHNCKYVQFIYMYVISFHTPWTHLFLQRLLLILYDEEAHSIRRKVAANYIASIVCRANFIDGQLVCSIVYYLFSMLTKFDYLLSQCPDSLASSIGSDTTPRSRNRFGESMNSRSTAQLKRCYSLQQDLLHIIGYHGGTIGMSPRCVRYLQEGRNSLCAFIDSRLHPIGHIPEKIIDDAIAATSIVPNLRKLHICLARAKEAIFSNDSSCLKGFTARSVESRYPFGSFTLYHSGCFVRDKYRLTTYFESQRDAVSSSIKAEPEELPVKREDLCHPSDVPAASQSSAITVAPAAATGATRVYESVVAQATEVKHERDYATCSATCGREQGQVEPVKSDVIMDSSLSSTDENAAALRIAVNTNASSPLKEDSASYGEQYEPKSQHSPTDSAASVANAIKDRLQKKHRRRWQSLPADVEPDYDFWGFNYATQSSSHSHGDTDTSTEGSYKKLKSDAAGHLGDPNAPAPSTTTTTTTNRHGSSDNNRLIVIGIDQLDDFELSLSSSILVNAPRRSSTRIFDMLTSTAAYKSAIINSAATKNNHKQSRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H7</accession>
    <name>A0A061D8H7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766236.1">
        <property type="nucleotide sequence ID" value="XM_012910782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H7"/>
    <dbReference type="STRING" id="5866.A0A061D8H7"/>
    <dbReference type="GeneID" id="24562591"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103640"/>
    <dbReference type="OMA" id="FSQGMWS"/>
    <dbReference type="OrthoDB" id="367249at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="27319" checksum="430D30529C4245D2" modified="2014-09-03" version="1">MSHTFYCSGAPTMKNYVFLYGIYLSSLLTAAERRVGQPVPHSPSSPPVGRSASVASHPHFKPKVRGSFIYREELDACPNLLNLLESSTEEGPKWKFVLHVVTCTLCMVGSCCLIFLSLLQTGRLFSQGMWSLKFYQSGGFCILGAAFAGLLLGMCLGFSLGTYYMAYLISGFMLLGAAVIYVGRRGAVLGAVGGTIVGLTLGVSHSGSVSAVVVEGVLCLFAGIAIGFIPIFPNLKINVRYIQHGVRANAMLGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M3</accession>
    <name>A0A061D8M3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767445.1">
        <property type="nucleotide sequence ID" value="XM_012911991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M3"/>
    <dbReference type="GeneID" id="24563800"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="62" mass="7466" checksum="F4775514290F9A80" modified="2014-09-03" version="1">MALLDTYTTDVYTLISHDCSLKLRDCFAVVKMAYWYVAFFWTETKQRYNKDIKFTTHNCKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8T4</accession>
    <name>A0A061D8T4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S acidic ribosomal protein P2 (L12EI), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0308560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769139.1">
        <property type="nucleotide sequence ID" value="XM_012913685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8T4"/>
    <dbReference type="STRING" id="5866.A0A061D8T4"/>
    <dbReference type="GeneID" id="24565494"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308560"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="66" mass="7016" checksum="F2252B79B16A49DC" modified="2014-09-03" version="1">MALKYVSSYLLAVASGNESPSVADLKKILDAVGSEVDDDCLEGLVASMSGKTVHEVSDRHVFYALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D985</accession>
    <name>A0A061D985_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766461.1">
        <property type="nucleotide sequence ID" value="XM_012911007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D985"/>
    <dbReference type="GeneID" id="24562816"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105840"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="7337" checksum="E36795A7708A11C6" modified="2014-09-03" version="1">MHQLEVDEMLDAWVINLYSNSWQKSYDAYDKLFKIDKKMRYVIWYRQLSSWRNGLCPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A3</accession>
    <name>A0A061D9A3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CW-type zinc finger family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0311690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769452.1">
        <property type="nucleotide sequence ID" value="XM_012913998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A3"/>
    <dbReference type="STRING" id="5866.A0A061D9A3"/>
    <dbReference type="GeneID" id="24565807"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311690"/>
    <dbReference type="OMA" id="SCMTHED"/>
    <dbReference type="OrthoDB" id="366391at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055300">
        <property type="entry name" value="CWZF3/5/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46524">
        <property type="entry name" value="CW-TYPE ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46524:SF7">
        <property type="entry name" value="CW-TYPE ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="5">
        <location>
            <begin position="217"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="664"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="896" mass="96079" checksum="BE973B42FB429F1B" modified="2014-09-03" version="1">MDLSKLAQPIPKQDAPPGPFEADGLAQLARKLDSVPLPSPSAVPVNGPGGEAPSTRPEYRTMSDAARAAMYPAAGGVNPKSKAVAPVKKAPGKLIGKLPSALAQAARATLAGRAESLSMSASLLTASALLAPIPDKLYDDDIPSPPVSGRTNSNGGRSAKPDVAADAAARRKAEAHAPPPTSPMKTRGSTRNTRQSRRAESKSSRSSRTAARQPSPVTTVENWAQCEKCKKWRRLPLSVDTEKLPDFWVCSLNVWDPAHNSCSVPEETFPDLKHHSQPATTPKAKVHASTGKKVTLPVRPVEPRPTSRGFNDRLMDHEVLELLFEKRSDHPLHKRLTVHSLGANSLLATELPHNVLLIDELPTAAALSVANDTSRPPSKLLHPAEELVKDDNVPRDDGTVSIGLARKTEWPTGDNDASTIDTVEEIDPGAEPPRSLLAAMFPKLALQVPKFGKFPPVKREELIRFEKSYNPDEHRPATSTSRSSGRAPPAVANAEVKTPNVVRSGRRSVSVMNAAIKTPGASPIDGKTPVTKATSATASTGKSPRAAHSGTKSASASASRASNAVASEAASAEHKGAALSSVSREDFRGLLSVFVNRKNKQPNGVARKHCLLEDKLRASTLPVESFLQPLSLLAMPIVYPTPEAPAEPAVKRSTRYSVRSAAMQASGVATSAPPEPAPVETKRESKRRMTTRSSRVTVPQSDRQLRRLREEYVRNSTGKSYVKKAKPSPPEPEVPAPATRRPVRRSTSRYARGAATPVAKPPEPEPVATQPTLSKKERMLMMELSIPIEHTAPVERRAASRGRSHRPMSSFGVDASKAMEMLTQPIDFVPDVKKAPGAASTTGSVPGVQPRMCTLDAPAMPALNLQLLSEPIPEFKPEPVEINVDVYKNPRLLTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9B6</accession>
    <name>A0A061D9B6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767700.1">
        <property type="nucleotide sequence ID" value="XM_012912246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9B6"/>
    <dbReference type="GeneID" id="24564055"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206720"/>
    <dbReference type="OMA" id="YEMECAR"/>
    <dbReference type="OrthoDB" id="364960at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="783" mass="88082" checksum="C1A706B7C8C2B698" modified="2014-09-03" version="1">MKQQAASGTSPTERGSQPPPVQRRIFEGRYECWSNEVSPSCSDSVYRENKSKYRNVQVGPVISADEVDALLCRKPNAVKNFINSLNEQMRQRLSPSVAADASVSFESRDYEPEFGRELQQCNVSVKNRITIFDRKTQQGDNGARLKTSAFRSEDSSDHAASPGERNMATYATEADTVVVGAAPKRPTFISSTPYEGSNWFAASTAFPRYVREEPASPSCLGTKLDLDRMAQLSQVGFNFGPPPQSTERSLTDVVRRISAPCNQYMPPMQRCMSDFSHEAERDPFDSARVRRKAVDSGRDSARYRFPGEWSPYGRGFGFADMNDTLNCHQDRSAWAPSLGRRTFADAPVERVELPLELVGRGYETKSDCSDGYADSADSGSQNCLSDNVAPYFTIHSSGRDIRIHTTNVIKAGWTWMHSAKARKWFPKYLVLFYDEPQCTRPYQLHATISGRTTNGNRDAASPSSFWDIYKIYSHLGQTTRVTTASENRCKDRDPSRRLSYNKGMPRDAPMRDPYDRPRHIWDADRRESIVIIPDNATIYLTILSGETDDVAGALRRGEFRELMEVDVGFMPYTKQHAPNHWLTGLLTRSMGRDPLNLIHIPLVDGYECCFMPLCAAHFPGVSLTYEMECARRNRVGREYEHWLFSLWEFVVRRGGSSLGSCTDAGQSFIIPVTVKTALGRLLRGAAEFFSNIWQRAKGMNKIPAEREEASDAHPFHGDFEVPEEQESLQSVLSGGGKTRCEVGSPAHKRALTRGFAQWINSRGFDDLSVSMNIYTLTSRFSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9E1</accession>
    <name>A0A061D9E1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766501.1">
        <property type="nucleotide sequence ID" value="XM_012911047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9E1"/>
    <dbReference type="STRING" id="5866.A0A061D9E1"/>
    <dbReference type="GeneID" id="24562856"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106240"/>
    <dbReference type="OMA" id="TMIGGQR"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9892" checksum="C8E2747B80BCE58A" modified="2014-09-03" version="1">MLSLTSLQADKIPTQSTMIGGQRMAPRKRAQSETNTAGTRTNMPVNSGFQRYYGFATSSIQMGPQAVLLLAIIYMGAVVVMHIVSRIKTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9G2</accession>
    <name>A0A061D9G2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0312040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769487.1">
        <property type="nucleotide sequence ID" value="XM_012914033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9G2"/>
    <dbReference type="STRING" id="5866.A0A061D9G2"/>
    <dbReference type="GeneID" id="24565842"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312040"/>
    <dbReference type="OMA" id="RGAESCY"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="92"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="330" mass="35323" checksum="7F7BCADF7687D627" modified="2014-09-03" version="1">MTISRALFGRSFLSPKLILERTPFGSLLSASKKKQFTPTLRQGAYQVLPPQPIPAHITRPPYAASRNESELRAYYSQPCVHAEVKNAQQIAAMRAAARVAADCLKRCMDATAEGATAEDIDRLGQEFIVSRGAYPAGVGFHGFPKAICISVNEVACHGIPDTRPFTRGDVVSYDCTVFHDGVFGDCAATAIVGEATEAVNTLVRVAKECADKAVAAVAPGVEFARLAEIVTSHAAAFGFGVVREFGGHFIGELMHMPPMVQFKHPSSTPGVMQAGQVFTIEPIICQGDPAIYTWDDGWTIATCDAGFCAQFEHTVLVTDTGCDVLTLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K2</accession>
    <name>A0A061D9K2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stomatin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0207590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767790.1">
        <property type="nucleotide sequence ID" value="XM_012912336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9K2"/>
    <dbReference type="STRING" id="5866.A0A061D9K2"/>
    <dbReference type="GeneID" id="24564145"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207590"/>
    <dbReference type="OMA" id="YLQMLPK"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="76"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="380" mass="42035" checksum="066234C5BEE64E48" modified="2014-09-03" version="1">MTSRLRAMSGTVLLNHCRDTLRRSIWSPNRFYSSLVVTPRLVARAPFAQAASSPAGARHLTTVNYMREKAGKRSHFGFVIVPQQTVYVVERFGKFSRTIGAGVHILLPLIDRISYVHSLKEDAIVLPNQTAITKDNVILQIDGVLYVKCVDPYHASYGIEDPIFAMTQMAQTTMRSELGKLSLFTTFLERDNLNKKIVEAINAAASNWGMVCMRCEIRDITLPKNIVAAMERQVEAERYKRSTILRSEGDKESEINMAVSQRQTSILKAEGEAIAERERADATAYALQKITSTLRETGTVDAVGLRLAERYIAAFDNLAKQSTTVVLPANVGNVNEMITQAVTLFKALGKDSQAPEQPVELMPPPPPLERAPANESSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L0</accession>
    <name>A0A061D9L0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair and recombination protein RAD54-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0107190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766596.1">
        <property type="nucleotide sequence ID" value="XM_012911142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L0"/>
    <dbReference type="STRING" id="5866.A0A061D9L0"/>
    <dbReference type="GeneID" id="24562951"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107190"/>
    <dbReference type="OMA" id="CKDSGYP"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000021">
        <property type="entry name" value="DNA repair and recombination protein RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="159"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="490"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="758"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="952" mass="105269" checksum="8D577CAB6CC4B8F7" modified="2014-09-03" version="1">MMRFNLGDRRKPGAEATEDALSTYSASYQQNSVQVCLIRAPLLSLLSVDEGPVTLFQPFKSPLQGHLPGISAESQRKTLGCKIRSFGRPFAPGAAEIGAFKKDGEDPDAGLPPPNPLVLYTSPEDAEVQITIEVDPMLSRFLRDHQRQGVQFIFDCLMGLKEFEGQGCILADDMGLGKTLQSITVMWTLLKQGFNGRPAARKCVIVCPASLVNNWESEINKWLKGKCPCTAVADGAKEKVISKFTGFKYDRRSNVLISSYETFRGHMSRLEGVPIDLVICDEAHRLKNDKTLTAVAIQKLPAKMRLMLSGTPIQNDLNEFYALISLCNPNVLGDVSEFRRRYANPIILGREPDATKDQQNLAAERLAELSYITNQFVLRRTNTLLSKVLPPKINMNVFCNLTETQQTLYKEFANSATCRKIVNSDDPVMAKTLGAILNFMKLCNHPCLIKPGSAMKSAAADATLKRIHETCPWNANSRSSYPELSAKTLLLFRLLHNIRATTNDRIVIISNYTQTIDVFERLCKQCGYPCVRLDGTLSIKKRHKLVTTFNDPTSHSFAFLLSSKAGGCGINLIGANRLVLFDPDWNPANDKQALARVWRDGQRKTCYIYRFFSTGTIEEKIYQRQICKDGLSAMLVTDGANELKDALSGECLRNLFDYKDTTVSDTHDSISCERCTEGVGYVPQTPDFVEDDLLTWAHHTDLQTVPDPCLKRAIFDNNPPIDVPEGYKPVSFVMSCLVEFKDVPPPKKPEQPAPQVKIENKTEDKSDNADEADVKTENTTDKVNKVKEEAKAIEPTVAAETTPAKRGRRGRKPKAEAVTEVPQQPEAVAEAKEDATATTRMSTRSGRGRRKRNSVDATAQVAPESPKAKRKTAATAVAAKPERATRRSPRKAALEEANVDRTNTASTDVELGDVAAEGELTDGFITDNEEPVAAEDGDVTEAELTDMGDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9N0</accession>
    <name>A0A061D9N0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0305910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768873.1">
        <property type="nucleotide sequence ID" value="XM_012913419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9N0"/>
    <dbReference type="STRING" id="5866.A0A061D9N0"/>
    <dbReference type="GeneID" id="24565228"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305910"/>
    <dbReference type="OMA" id="RPRNVNE"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="133"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="399"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="590" mass="65112" checksum="99155DA65378EF43" modified="2014-09-03" version="1">MNVHGLYHLCTFIGYGVAPGPAFHDAGVTTAVRATGFHRSRPPSGFLGVDERLRDASPAPRPKRRELVQVPDIGADGVVSYAGVFKDADFLPRRALEDVDPGVLAPTGAPTAVGRMLAEVGIERLSRLQLALFDELAYGNNALFHSATSTGKTFSMLLYAALRYYYGVPPDLLCSRKVHQLFEYATTAPPSAAGLFQPPDSRALQRVMVLCPTKELAIQSAKQLIAFAGGDKDCVRLIIDDQEHLPEDIGPRNVFVVGSANQLNVYLLTKSKSYVRGIMQHVGLVILDEVDRLLKVTNQYASERKKLMYRKHPTASFQICQALLALSPNKLQLVGASASISRNHIRFFDTLIQSYRTVRCPLAIIRNRDEQTAANRYVAVPSSVQHYFAVSNTDSLGNKVGKLVELVRNRAGERAIFFVGSQHSLLSFTHYMDQYGLKCKVLHHEFGIRDNVSKRFSGEVVKGLYDHRESSEALDMFEELHNELDTDGGDCRLYAASMDSARGLHFPTLDTVYMVGVPRNVNEYVHISGRVGRCGRVGNCITVDTIANVKKVLAWQKGIDCTISPLDASDATALAEFRGYAPHARNDDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9T8</accession>
    <name>A0A061D9T8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A', putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0208330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767865.1">
        <property type="nucleotide sequence ID" value="XM_012912411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9T8"/>
    <dbReference type="STRING" id="5866.A0A061D9T8"/>
    <dbReference type="GeneID" id="24564220"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208330"/>
    <dbReference type="OMA" id="PNYREYM"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="24498" checksum="85BC7DE2A28741A5" modified="2014-09-03" version="1">MELKSEQIAQGRQSLSPGGDRTISLRDLRVTAIANLGVTRDGYDCIDLSNNEIRKLDNIPLLPRLRTLVLAGNRISKISDTLGDSVPNLSSLVLAGNNIAQLSDLSPLFKLIKLERVSLLDNPVIAVPRFTEYMVFRLPSLRYLNFCKVAQKDRRSAAEFFRTEEGLSLLREHGYDPFASLGGVKERADVLAMMEKTTDVGSLLELEKRLMQPESGVPSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA31</accession>
    <name>A0A061DA31_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP synthase subunit C domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0312860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769569.1">
        <property type="nucleotide sequence ID" value="XM_012914115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA31"/>
    <dbReference type="STRING" id="5866.A0A061DA31"/>
    <dbReference type="GeneID" id="24565924"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312860"/>
    <dbReference type="OMA" id="TSPYMWG"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="9">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="172" mass="18272" checksum="2B5E95FC05498223" modified="2014-09-03" version="1">MAESWSEVFSRIPPHFWGHMGIFLSLGLSVLGAAWGILLCGPSIMGGSIKEPRITVKNLVSVIFCEAVGIYGLIVAVLLVNASLHFTAIECPKDFKADLTVTGKYFVEVYRGYSMFATGLIVGLSNLACGSCALADAQKPQLFVKILMVEIFAGVLGLFGVITGVVLISTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA51</accession>
    <name>A0A061DA51_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769008.1">
        <property type="nucleotide sequence ID" value="XM_012913554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA51"/>
    <dbReference type="STRING" id="5866.A0A061DA51"/>
    <dbReference type="GeneID" id="24565363"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307260"/>
    <dbReference type="OMA" id="RAKRCMY"/>
    <dbReference type="OrthoDB" id="364669at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1148" mass="132335" checksum="FEEBB8856CC7A502" modified="2014-09-03" version="1">MTSRLLFTNQAGGIAWRAIQLVIVMLCGYCAWVAVAMSTSESAVINPHAPVSASTRKSTRGSHPAAYIRHAGSDAMPVHFSMGDMRVRRLWMMDDYAGDNYGYNEYRGTGRRYHTRGDRRRLGRFEQTFRQLRPESRPWVTEDFGGIPKLPLRTPIEMGRDPVIDEFLEMRKRQVPHSLLKDYYMQRLDGSDEEEGNGDHPRRIFRRNYEDYYLYLLGEGIMPQLQSDDEGERHSETRHDAEGGSAEEYTGEITPDEPREYERQRDRLTRNEEYIKMARERQGSYSHKDKIFQFLLAAMKDYERANVNSEPPEDIPENLEIMDPQLEDYFLTDCYGSPIYIAQWNEEYLKGREGLEGKALIDYDNMWYERIDRLNSHFDHLHTDDTPGDVLKSYFVDADAGDIPIRRSKSGHRKPPRVVIAGKALKMKWSEHLSPSILELLAKNSLRRHRDKDEQARKRRMLDFKADIFNACVNASMNRLVHERGLRQDEEDRLKYIQHLHDRRKVHNDRFGCQPNTPYWIWEEFWKDRSSILQDTMVEILRSVRCVEPDADVAELTKGTVEHIKSPKLQGTRFEVPMMLDPDSSPKVDRLEAYIKRFGRRSDASTSSPPEASTAPSEGSPRSIGTPSKIDDGSTSGQKRSEIDGLPVPKPLGYYFRDVLSFDKFEEEYEKFNMECFGTKDYGVSVGQLVKGTVEDVKPKRLLVDIHTSKLAVMRLVDHFNSPQEVPSGGFTSVFKKGDVMYFEVISKYGNDINVSTLHVQEMYKHREIYRKHFKREIFKVRAIQRYSSGLLVQYQGDDVEDIEDYQMPDEPRRLENLAFIPYRELDRTHRSEVQRIKLGIVGKVLPVYIADWAVCDGVPLVSNIEALRRLPLGQIQPGDIIRAKRCMYGKDAVWVHFGHTIGTLSVMDMSKEDYAKHVRGDTESIVAAVRDVHLLAGSMELYTKGAKTSGVGIAVNEWKERMRLDPDPIKSFNDAVAARMPDILKSSVPGRVNPKNVKLNPIHSVPNRRITLSSTPSLPPGKSEAGISRFEPIRWDFSPTASKHKDEDELQHAYNTFTWQVLTEHGWADLTPAEQRVFNRARFQNDEVVYYQHDGRSYRADLLDMVRQNLTDLVEQPLRNDCYVALNEKEMRAVHGINLPNSDPGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA97</accession>
    <name>A0A061DA97_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0209470</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767980.1">
        <property type="nucleotide sequence ID" value="XM_012912526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA97"/>
    <dbReference type="STRING" id="5866.A0A061DA97"/>
    <dbReference type="GeneID" id="24564335"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209470"/>
    <dbReference type="OMA" id="NKSWLMT"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="271"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="600" mass="67793" checksum="BC189E58CB71B9F1" modified="2014-09-03" version="1">MSSLRNFRSALDSQTSSTARHQAQPAAAKSPLTNKRECVQCILAFLAARDFHPCTAKELLRSPPLQTLLDIWNFLFSYIDPNAHITKENMAVEVPKFFKEFGYPHIMKTSHLRTPTADHQWEANLVALSWLCKLLLYEQECFDKPFEVTKKRHGSPYMGLDFGAHGKATISNTMVAQFVTEQATKHFQLYLKGEENSVQLVEQFHRDVTELVAGVQDSVDGKIRELEELRGQTLELQEELESFARTKEWIEKANVELQRIEELTASVRGTCVQAAETLKRHKQTLRDEEAALAAQEEQNADIEKLIEQQDINKNVVQELNNTIRALKVRIADGNRKIKELEHDIASSKTTAQTMESQLVRLQKALASTHESIRNFLVNNGRHAESWRSLGQLRINPQGINESEILGVEPATYNGVLQDVINKDREATHESSEARTELEQANQHLEALGNEIARETSEILRETSSLIKNQHVEEKDARVQLEASELAAVIRAAANDELVSRLDNRDLRGLTGAQESTKRELEAVEAEVAVAHAQLQQQDAAAQEAWQVFVNRFKEMFQIARSSKESNCHALRGDRRLIGLEHRLFSGGDDTQHEAASETTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG6</accession>
    <name>A0A061DAG6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769877.1">
        <property type="nucleotide sequence ID" value="XM_012914423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG6"/>
    <dbReference type="GeneID" id="24566232"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401820"/>
    <dbReference type="OrthoDB" id="366186at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="105" mass="11408" checksum="142F7D1B7F01C619" modified="2014-09-03" version="1">MKKDNPEPSDNTISEPEDAEGAAEAISVEELMGSIMKGVSKAFSTTIANKTRGPVKSSEPEPPKQPKRPTRVSIRKQPDEFPEADEQRYKKIANNGGGQHSCNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK5</accession>
    <name>A0A061DAK5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769769.1">
        <property type="nucleotide sequence ID" value="XM_012914315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAK5"/>
    <dbReference type="STRING" id="5866.A0A061DAK5"/>
    <dbReference type="GeneID" id="24566124"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400750"/>
    <dbReference type="OMA" id="MEDERAW"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47455">
        <property type="entry name" value="ADENYLYL CYCLASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47455:SF1">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="467"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1132" mass="125726" checksum="C48248F32C3F30C9" modified="2014-09-03" version="1">MFTASGLCCVGRGKSGDDQLADSDFLDIDDAMREADDVREEWQWLSIRCERRLNEQLHFYQQEITERCDELLANASTPTDPSVYGSYVPKLIRRFIHGRLGSTNPSPRHIANCYAVTVFCDVSGFTALAEAIEKSGDPEAAATLGRSLNCFFDPLICIINRWGGDIMKFAGDAVLVAWFINENYETSDCAVDLENNAEESEENYISPIYSSKPPSGDVWRQCALALRCCEELHATLHEYPTNIDGKTLAMHIGVGLGEVAILHVGGLLERWEFVIAGKPLEEIAVAEPLASRGQTVMSRSVYEVMQSHVKVQPIDGHPDYFLFTSFNTELEVEPDATVHESFEFPPDSVTEFRHYMPSYIFLRLISGYGVFNNEMRRLSTVFVCVSGLDVASPSGRETAQQLMTICQRATYALEGSINKFLVDDKGVVLLIFVGFPPVYHTDDPVRSVFVGLKIVNDCLKLGLTPGVGITTGSVWCGTLGNDIRREYTCLGDYVNLAARLMSKAVTSTDHKILVDEATANEAGSILEFNELESVKLKGKEVWVKVFSPTGKVRQLDLQSLEECTPLETWKRWEAYNTVKKRLSGSGLLEHGGVMLINGHSGCGTIDLQSAITRLVKRQGYSNCFSVSTMKDDSSAISIASDSHLAWRNLCSGLVSTWAASSSRKAMMGVYHSKYQHMQSENCVSKKAVSDVVKELLDPSLHWRLGSLKPLVLGLEVEPLRNVVGHRLTPRSQPNSRIPGLMQGLLSENVDTNVESKTGPRGNDVNRSAQNTSTCDTTLLDQRIVQESTAPFVTSMVDGFTMSEGLCVILNIRLGSSVYATMEDDSWETVCSLTRLATERREARMAGATNSKPFLFIVVSCPQHVFLRWHDEIVQHAEKCDARIKLSKLSRSQLTDFVAHTLQLEGAASVPDELVDHLYRNTSGMARFVYKTLQELVESKAVILEDVEFSTSASSEVEEESTPSNSRAMLRSQIMDFFHIPRRRGAGIGGLQQIRELGVSFEETPKHRKRLVGLNLPTDGLIDEILSFAMSLVDRLQPDELFVAKVACVVRSPFVRQDLLVNNPQNFSEEYFDSILRSLLANEILESVSNMPIAEAMAPNVELRLCSSAIAKVLSQRIMEDERAWFASQFVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAW7</accession>
    <name>A0A061DAW7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767041.1">
        <property type="nucleotide sequence ID" value="XM_012911587.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAW7"/>
    <dbReference type="GeneID" id="24563396"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200120"/>
    <dbReference type="OMA" id="DCATNND"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1477"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="931"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1477"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1766" mass="197910" checksum="51D129D7E7EA03F9" modified="2014-09-03" version="1">MAVDRMIPEFSTLKQCLEFLYWLHTDKQGKGMQYRVTRRLKKLLEKKYISFDPNDVEVALSTFLRRVSTFHEKLCKKAGQGDYNPGKATDALYALLRCIPKFLAVIYFLRYQVDDKFGAIGGGGWKDYWLGYGALGGVLATRGGELDKYLYAAATETRYGVIPGGFDIGGQEVNFRSGYRQGSAMAGDLQNICEKQNGQYFRDVFVTSVLSNKSGVDVSNVANALRLVRDFCGIFGPETNENEFKSHVQSRGNCIEWDKLKSHCFTLKESLGKLFTGGAFSFTGYGRQYKYLDKNIDKRMASWFRANLNEVRKQLAKIESFTSKNYNHRKRNVPPEYYTELGAHLTKYLFPYGFTFDANSFKTGTAPYESLKKVWDSVIGDLKNIGGGLDEFKKILDGTACTNRKKDKEYKPKTEPESNAEIGPEDEDQLEDGDELEPEIESEDESDDYLDSESENEDLPDDKTEATKTEAAKPAAPKPEGAQNQGKKGEGAQNQGKKAEGAQNQGKKAEGAQNQGKKGEGAQNQGKKGEGGQSNATSPDLSAAEVVQTQNPSASSPDSEASGAPSPGSGQGPGGPGSTSDPAQGSGRGPQSGATDSNTVSGPSSGSGGGGAGGGGGKGDDDLPQKVTCEGEQVSLYDIGGKPACYPKPHNYTSNYYNPDWDDVWNAQQRGMLKDENITIPIPSEKSKSRHRITPSTLPNQPSRPAPGSSSLYPGSRDGHRRPYYETGEGQQKQGSGSVHHNAVVDPPVFFMDGKPVQAYYDNKQRDAKDRMAQQYKIYEALRQSRERQDMEEEVNLRNEFDQKQKEADAKWNIEREGEGKRAKKYDEEVDRIQKVLDKGRRDTEARRRQEVFKKKPIVSPPYVDGFRPTENRQWQWWPWWYHDLPNSPISGSPVDDPTNADDKEMENLYHKELQDKITAGVDNRIHMLKMEAEEKKLIEKDKKYAEYKLQSEIRTQEAIERIKKRNELKNRAAEKVEETLKDTTEAIWKTQLQQNVDYIEENVRDADAKKRLQQKRLRQQKQVEQQNVSRDSPTSTVSALPSQPSRPAPSPSGQIPFSSQPPSGIPANQSPQYVPQERSSRERVGDIEPVDLPMISVGGSAVPDFEHEEKEAKLKKLSLAKQTMEKWDWDAKQAELYKQMQKEKVNWNTQVREYRDNLHRQSHETSRTPFLSRKSSVPIVQNVDILVPPITARNISGRSIEIPTVQLDHDSAFTASAIQQSTGHNIPDSKINFRKSPFTPPSKPTGRDNSLTQSPHTVTFDDNIMLSMTGASGQPVVGVNGKVDTSQIPSDIRVNAGDRYHLEGQEVQDDKLIKRQERNIQNLQNAQMQIDSENKQRERKMQALKEESKHINDKQKELMQAAQVDADRIRAFNDSQFDISSAPPRNDQIPFEIQIDVPKRPLQDSSYDIDLYDPYANTADILKDELKPAEGKGFSGVLQTNFDLDFAPERIGLDGYEDPGMPRDSPRKADERVINPFSTDECQNPWSFDTSSTDTPPPPASPSPDTDHLPPPRTVREMLYWFVGLNTYGFIGMITEYVECLLKNANKNVFDMPDALEVTRDPYNLNSSHVADKLTEASLYSATVIYKIRHNNDFKALPPVDFESVYSQFRYSPDPACLLCQLRDYAYACHHQLQFLKAQCNRDKLSGGWQSHKYGNAVSPSDSPLQAFLTDGWDSTFKTHPFDPCNLCHKSRVRMGLRKGDLPKISKQGSVISSILTPSCGGSDPLLTLSAYLNCLTKLHGHCHQLGLSNHSLNSDQSQSPCDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ0</accession>
    <name>A0A061DAZ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767071.1">
        <property type="nucleotide sequence ID" value="XM_012911617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAZ0"/>
    <dbReference type="GeneID" id="24563426"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200420"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="108" mass="11984" checksum="412B4A5057280F90" modified="2014-09-03" version="1">MVPVDRERLSVTRAQTSLHKTTKMGYENRGNAAGYLEAHRATYAVAIRLSCCGATTSKTPPKQTQMETYIIKATFLWLSLMLKTFCLLVKCRMGHGVGMPGAGRFAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB34</accession>
    <name>A0A061DB34_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0403740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770072.1">
        <property type="nucleotide sequence ID" value="XM_012914618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB34"/>
    <dbReference type="STRING" id="5866.A0A061DB34"/>
    <dbReference type="GeneID" id="24566427"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403740"/>
    <dbReference type="OMA" id="HTYVLYY"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="269" mass="31291" checksum="C55DC0C9782870ED" modified="2014-09-03" version="1">MLKSGSKYDVAVVPTRSTKQRFAMVPTEERNETSLSSLLDSREHWWISRYIKAIQRIPPVTGVYVALSSISALLAWALNENYMLDALQFDLQRVKRGELWRLITPFLNFGPLWLAHMFMLQSVVLYMSSVEISHCARPEKFVEFMAFGLALLSSYGVAEAIAGRHEATMSSAAYHLHTYVLYYWSRLNEGSVVNCFDLFTLPAESVPLMFLLQNYLLYREFYFADIVAIGGAYIYFYYLFDTKPVWPLRRLRGGRFTRLYQRFNNEISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB75</accession>
    <name>A0A061DB75_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0201420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767171.1">
        <property type="nucleotide sequence ID" value="XM_012911717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB75"/>
    <dbReference type="STRING" id="5866.A0A061DB75"/>
    <dbReference type="GeneID" id="24563526"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201420"/>
    <dbReference type="OMA" id="TGPTIRY"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="4">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="410" mass="47082" checksum="9001253E6982E2D5" modified="2014-09-03" version="1">MAAAAEELEEQELEETEAEESEELISGDEEGGDDDGDDDEDEDDDDEDDDDDESESSFDEMSVGVALGLPKRQNRGKKYTQLVGEELEKDQQFWGHNTWEEEAVDEDYNCSEGEEQYAYSTDSDFDDPETDKSDEEVDESQFKEKKKRKYGSYVDPALQRSKLARKTLDKQNAEKSRGDESERTRRQSLQGPEPGADRSVRASTKWKTEITNKMERIRGSSKQAGGAGAQKKTPKKRSSMTQEQLMANALQTEAANARSLANLQAWEDEKKYYEDIKKWNYKGSYDIWVCWNSLLSIVTKNNEAEQDAQPSPSSHVTEKPLKLYMFTSGKLPEFYTQQEEARRRRDLAKQPLCAITGKPARYVDPLTRHYYSDEDAYNAIRMDHADRENQQMAAELDHLEEMLETLYDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB91</accession>
    <name>A0A061DB91_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tat-binding protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0300840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768365.1">
        <property type="nucleotide sequence ID" value="XM_012912911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB91"/>
    <dbReference type="STRING" id="5866.A0A061DB91"/>
    <dbReference type="GeneID" id="24564720"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300840"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="182"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="405" mass="45677" checksum="BBD7772419A728BC" modified="2014-09-03" version="1">MAATGVQSDDIQSHEAENGLIHYYRYRIEDCEALLHRKEQTRRRLVAQRNELNAKVRELKDELHGLLESGSFVGEVVKQMCQDKVLVKISLEGKYVVDVSKDIDISKCTPSTRVALMSDSYKLHKILPTKVDPLVALMKVEKVPDSTYEMVGGLEQQVKEVKEVIELPIKHPEIFESLGISQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKYIGEGSRMVRELFVMARAHAPSIIFMDEIDSIGSQRTDSGHGDSEVQRTMLELLNQLDGFEPYQNIKVIMCTNRIDILDEALLRPGRIDRKIEFPNPNAEARAQILAIHSRRMNLVRGIDLEMIAREMVNVSGAEVKAVCTEAGMFALRERRVHVTQEDFLMAVAKVMKKDADKNISFTKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBA0</accession>
    <name>A0A061DBA0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPPDE peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0201770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767206.1">
        <property type="nucleotide sequence ID" value="XM_012911752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBA0"/>
    <dbReference type="STRING" id="5866.A0A061DBA0"/>
    <dbReference type="GeneID" id="24563561"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201770"/>
    <dbReference type="OMA" id="WHTSIAV"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="98"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="257" mass="28065" checksum="7C064402F5DB70A4" modified="2014-09-03" version="1">MLGRLRLTPGSTSFARALGILVLAVLVLRSLGPVVDSAAFRISSAPSALRIPAQKLPPPSATEVNSCECPSKSHLASCSLKRASMSEQLKDDAGAGLTPVYLKVYDLSRGMASMISMPLLGFQMDGLWHTSIAVFGNEYLFGQGISYCEEARCEEATNLPLTRKILLGETSVTKELFHEYIDSLQVTFSPESYHLLRWNCNHFTNTAAEFLTGNGIPDEYVKMIDRIEQSPSGKIVLGLIEKSFNRDPSSFSVPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBE5</accession>
    <name>A0A061DBE5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0403410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770039.1">
        <property type="nucleotide sequence ID" value="XM_012914585.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBE5"/>
    <dbReference type="GeneID" id="24566394"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403410"/>
    <dbReference type="OMA" id="WTPYELV"/>
    <dbReference type="OrthoDB" id="409931at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1491"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="731"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="873"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="951"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="841"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="880"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="954"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1863" mass="207618" checksum="0FE856B85921F3E8" modified="2014-09-03" version="1">MADYISPPVGMAPFHDGTELGRVLSKAKWITMLNTLEAGGHAEQLLILSELSTYLSYATEDTLLGFPAWSYLKVLMHMIQHPRVKYASMKKRKNANRAEDLTCLDPDLPFCKMIESQRNRAQRQEAEQAAMLESSDDEEESDTGAFTHPDLPPHINLLPHELKNRPTIRDRDVDLISEDMAVNKSITAASCVNIILDILPHAASFFMSNSAQLDALQRQLEDIEYIDLAERILLIYEKLVKEIPVTVVKSGALITMMRFIDFFPLDVQVGTLTAIVLAVKRIERGDSVRNFLIPLVPYATQALRNGNKKIVQLACCMWKSIINTMLRASYKNTSHLSEVMGSMVRSVVSCDAVRDMCTVVFKSSGKLNRENVEECIYCLAVVTNESNELMSQIATIDVLPIMSRWLGNSCDSVVLRLVDLGLAMLGSYHSIDPLVIDCNQLYHRADYYSDFTTHLQAVAETYSIRTLVDIFDNTASQQLRNRLLLMILRLLEMACEVPICVGHVIDDLPLFKVLDAVCYTLRFQSQEEHSEVAVHIITCLMRLMEPRNIADTLGRYGLSALLRVLKRPAVQHEVRYIMDSLPPPPTHIVTKSEFEMIAAIKDNSVALTHHELLQYGLMEMNYAKLVSPKALPELLGSVIKDAGQYFAPSVNEAGIKALWRAFGSVLEAQPEFKPRIVKDFDSDDETTDGSPMQIGWYEEAMQPESSETSSLTASSEALAMLDTCSLTGGSVSLNRHPAGEGANTGGSTSSGRANNSGVGASSSSSSRSRSSGRQLLISTTPGSEMALVSDLPECRVRPEDIRTSPSPIEIRRTMLGTPGTYDSIEVVEHVQVTPLYDDDQPQQQHPAAPSQPVANEPTLGVAEDGHMVPVQDAPSVVENPAPTDAPTDAPTDAPQISSAETPSAAAPEQSRESSIHAELNGVIAQMREDGLGMEDVLDSVEMLAQHYQDNPLLNARTRANTTTASRTRSRRSESRPRKNSDDRTRRNGDQHRKILEEQAQFRNRLRHALSFITSYTRSDALPYPLNCVTREVKLQISCIDTDELLVGIAPLSIRTPSLVSVSKIETYVLTYLNTHIKEPPKDLVLSPNKRARLYTDDGRFGGYYLGVQLYYKDRPLAPSMCLYQALIMLNGGEKGAIWEEINELSYTATRRVCGPTWSLLLSGRHSPLVAQLCEDRHSPFGLFLGLSSYVNGVGKAALPEMIRVLKERLVYVDGREDAVEMRAILNEVMKIRPPADASSRFSLDADATESFNGMTISSVDKKSKPVKHADINTPEMDYYVDCVAQALERMDEILSGRTSDDVLIATRLTAGEESELSEDSRNQLQMMVVIYTLMTELSLFLDEDPIRVPFSKRMTFGMLNLLSNVGEALCYHTPSWFVQLMLICPYMFSFETRRMIFDVLATGPHRLMSQFQTRLCALFDTGTVFSKYSEAHTADSLDEILRQRLFTHKTVKPSALVDIETTLRLPKLKASCSRLHVVRDAMIIMDQVARSVADLDAVPRLEIEFDGETGTGSGPAQEFYTMVIESILGAESNGCSPVEVINGYVYPKVYHPPSDWVDDFDLSVFKRASKCTMNGRAADGYGPIIEEMMDDNVTTRVFRLFKLLGQMCASAMLDNKLLEFNLHPLFWKLCQNPYSPKNCSMYALSAVDPMLACSLTNLLTYENVADAGLYFMYQGIPLVEGGENVLVTTENVIDYVRGVIRVRLYDGIRLAVWSFRMGFAMMVPVDSLALFTPLELADEIFSTGDNDAFWTRDHLLTNIVPDHGYESTSAPYQTLINVLTELSEDERRKFLRFCTGAPTLPKEGFAGLRPLMRVVKKCDSSNDLPSVMTCSNYLKLPEYEDLDLVKTKLLQAIAEGQGSFYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF2</accession>
    <name>A0A061DBF2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Triose or hexose phosphate/phosphate translocator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0405160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770217.1">
        <property type="nucleotide sequence ID" value="XM_012914763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF2"/>
    <dbReference type="GeneID" id="24566572"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405160"/>
    <dbReference type="OMA" id="SYPLAVW"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="47"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR98031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="361" mass="39596" checksum="B6858FD159D5100B" modified="2014-09-03" version="1">MSESALTIHEVPQVVEINALVEESATKLEHNAAAVEKPNVDWWSHIKLWVAIGVWYGLNIAHIMTSKSLLNVLPLPWSLCSFEFFVGWIFAIVFWGTQFRPMPHFPSITTFAKMFVPLGALTVLLHCGTILSMALGTVSFTTVIKSAEPVATAALSILILKDYLNIYVYLSLIPIVAGVALASAKELDFNVWAFLAALLSNIFEALRTIITKGLKQDDERIGSNLTPTNVYMLFTLVAAVLCLPVALAIESPKWRQVWAESTASMTGGEKAFVVVRFVACGFLYYVYNDCAFYCLGLMNQVTHSVLNTMKRIAVIVVSIIIFKNDVEVLGYVGMGTAIVGGLLYSLAKQGVCMRQKAVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF8</accession>
    <name>A0A061DBF8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767266.1">
        <property type="nucleotide sequence ID" value="XM_012911812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF8"/>
    <dbReference type="GeneID" id="24563621"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202370"/>
    <dbReference type="OMA" id="SHCERIL"/>
    <dbReference type="OrthoDB" id="419431at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="74381" checksum="4D514D26D5C75D96" modified="2014-09-03" version="1">MLPCSRILRLCSLLRSHCRVSRRGFVGIDRPLPDDLFQDTAVVGTEPSASFGALQACETALVPSLDSCSSIEDVCSVFKERRPRLKPAELILLLSRVVQLGCRHRRDAGDSLCELWPRTDFCLVELCGWHGRLDVMRLPSGVGDMYTDVISRIDCFTPTELLYLVRMGTYIRGYHNRILRSHCERILSTCAWRLDHTDLCRSATALACSSDSVPFAKLIGHVCTSRLLEFAPAQRMMVFGALAAARHGATLFLQSCARHALNRDVFTGTDAVKALVCYARKPSACSPAVFENLLRRCVGLDLSCLGPLELCDLLWVTCKYSDMSREMFRRCEPLLLQHCSDLPGRSISMLLWALADSGFESPALLSALESAATAAASSMSPANAALCVNSLSQLKGAGAASDFHVKIEEEVIANIMHFNGLDLAMLAEGYARLGTGSATLHQCVQEYALRYADDLPADCLSKLLWAYGHLVGRESFFVGLQFPLLQRVNQFSAHELCRALWSYAVQRFFDVTFWSSCLTLLDVNQVRGNRRCALLYPALSDLVAVRKELLTADVLRLLNLTKSMFMDDESAAYCAATGERLASALGSLGVTASTAEAFEGFLLDASFEHQGVRHAVLVYTRTNTVDSGSRPSGGMILKARHLRRHGIKVLHVLRDAFMAMDERQRAALLSRQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBI3</accession>
    <name>A0A061DBI3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome A-type and B-type family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0202670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767296.1">
        <property type="nucleotide sequence ID" value="XM_012911842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBI3"/>
    <dbReference type="STRING" id="5866.A0A061DBI3"/>
    <dbReference type="GeneID" id="24563651"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202670"/>
    <dbReference type="OMA" id="CSGCWCD"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="217" mass="24117" checksum="EB45B9D99CB43BCE" modified="2014-09-03" version="1">MERHTDFNPYVNNGGTVVSAVWNNCAVIAADTRLSVGYAIHSRNASKLKKLTSTCVLGTAGMQADMIALQVTLMREIEMYKSKQYKEPPFRVIAQLLSTILYSRRFFPYYTFNILCGVDENGQGITCGFDAIGNYGFEPYMAKGTSAALITSVLDNHLTSRNQEKHEEVKSLEELINVVKGAISSAVERDIYTGDCAEVIVIDSMVHEPIRMPMRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBN4</accession>
    <name>A0A061DBN4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0301930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768475.1">
        <property type="nucleotide sequence ID" value="XM_012913021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBN4"/>
    <dbReference type="STRING" id="5866.A0A061DBN4"/>
    <dbReference type="GeneID" id="24564830"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301930"/>
    <dbReference type="OMA" id="FNRRNYE"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="214" mass="25466" checksum="741AB0A6A95E9866" modified="2014-09-03" version="1">MILNIFKLSERLASWHNATGIARIQLSAPGHCLRLPRANFGTKRVTQKRRHMLRLIHPEEKHTNKELRDGWLSNDDALPKSLLCNSAIRKLVYSNTVEAQKLARKVDWDAYKCNVRGVRWHPSGSWYVQFNRRNYEKNFFVNCHCYFRVDEHGFHDAKEKAIAYRKRLEAEYDELQETWHEMDKKRMEERARRHGDRQMALEEEEFLLADSTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBQ6</accession>
    <name>A0A061DBQ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768480.1">
        <property type="nucleotide sequence ID" value="XM_012913026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564835"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301980"/>
    <dbReference type="OMA" id="WCNGNYE"/>
    <dbReference type="OrthoDB" id="360842at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1669"/>
            <end position="1689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2261" mass="251970" checksum="DECA983141D44E7F" modified="2014-09-03" version="1">MAAGGVTPTEYISQWCHGNYEVMHSCLEQLCRASKSHLPESVEEEGATDSGGFWSRFWRRPNSRDTKSASPPSRRDSINWLSGLVSNDSVTVDGTRGSRPLTSVSDPPEGDVTNDALHKMRCGVISGFRKYPFHRPHLIPRRNSSITEADVRDYVRKKFACVERSLDQIDLFSTLANVDQYLCCEMLYEGICYYGNESQSMSEFAIIDGMLHVQSRCQLKSLTLLLSFVNGGKMLSDATAAADAVFPEGVSILRDLLSRGLIKNICLLLLTAIKESSRYKSMVSGDLSSFIKALYESTIDLVNDLLRFLESYFLRFHPAKDELRCLVALLPNVFDLKALFDSSDYGALLRSVFGGSSDALSPWYPSSDVLLSKCVGVHEFDEMTKNVCNVGNRLSLIVILSLHPQHYRLLAISENGPPLKAYLNKDSDSLDRFKSTSKPFLEDNDLIKVLEFVVFGMYVNDTDRMIKGLDCGVFAHMGSLWVMSTPLNYRDTVVEILDTILNAFLFSNGVLGKRWYDIVDYEIRCKRIAEDRARLPYTGVRDEALYRNPGRSIIELLTLVTKLGAKGNKRYAFEIWRSCAESYRSLIPNVNCHVYTYNSFENDLYNCCDDSNVDKKTVERLIVPSDGFSWWERNSALLDLVTVAAGDGNTYVETYPRLLSCLLEFALYLCTVEDVEGECLSHLVGKFLSTSASREIRFPFLLERLISQIGGMTEGHYSRLPGLIYEKLLARDDQIETAEAALMIASTIPAHPSQQSMGVGSCLRKLYTFPLISGAPEVKIALGTVGLGGRCPFGLIETSIAAFKLVSLCDRIPEGPNPVLKAPVHLDVNIQHSTDDGDRSFLSAIFSILSRSRMDGLELLTASVLSSLCSSHIRDSGTACAALRRLAELVQASKNVAVKGYATKGYVLSVEELRAFVSCVRKLFVYVPRVERFRYEGVDWLHSLVQFSLWILDTHCFRNECVHWSLVSDVFEFLSEVAQGPIETCDNSSRASQYLLEQFLLPASSLCVSLVRAASEAKLLSAISTMCIIFKRDVLLIMSHRAATLMSTHRNGSHCSHCGLPYCRVERQRPHLTNSDMDVDASSASLDWWSNKIRKINSIFSSSSARDIADEKTCKCIQFDMQSMSLLLAHDAVLEAMNTLCLKNENAICPGKSCEFIGCFDPNVSEEIRMKSVFLLLLVVERMGSASLVVPSDVLRELHRYYSLLHPCEERSQYVMYRSMESEDLVLYNKVATMVANFNRMDVSEHWYYCTSQLCDLNRCGLDNLVLLVLKQCALKAAFTKCDKDFALRLLGSANNVIALIRLASGGGDMWRFSDWRRMDALSAVVSFAKIYPHVLELVAHHWSSLADEASRIDFANLPHESYVMQCQRLSNMLQLLILLAERGAVCISSDDMTHYVKLYSRFVKCMSEVTLSMRDELDALLNAITTGKGGIGAKDFVNLWKVASFPSNLCLVFDLQLCTKLLNPQSCEQLHQGTQRYALRVNSSNMVIASSIGLISCLLNFLSYSTKLGIVGLSEKSRTWLELSCVEFNPEDTCELRLALHAALIKQLGSIWLASRSDILGNDCTLSISIVLKLLTFVLTHETSTHLRSKIYACVNLFLMNQHRTNGASITELVVAHLLSPSSDLSGPPTDDRPALLHLLSSDATAILHDIGMSRYYSVLDVSTTNEGVVPSPEDMSPEATDRSNGSIYPMSSGVDAPYAVSGLRRIFVGQDYTYLQAPHLDGMVVSDVAELEANRSSEVLFIAVDSGVRIDYRVEALDLLSLILRALRKFEAGAIEYDLGAVNYGSLGSISTDSVSLLLHNRFLDFKRCKQCLLHSPYCHLCLKLLTGTARVLKAASELQQFSAFWYHVQPTSPSMCLADLFLSCDLLLGFTNCDKLPTELFNPFICILENLLGVPSVKTRNALIQWMNRHSELLGSLIPLNASVPLTDDRVTLASSLLRIYRVCVLWILAEYRRAKFNSEPLNNFSLILADLQCKFPLAMSMPRSVPALLELLTAELSTSSDCYWQCILLGLQSVFPELGAFEADLDFSTQTPIKALAIEKAVTVATVLTRCGSSLLCFINHLNFLDPKSRRKSLGRFALRVATVECAATLLEYILALVLTNCSSASTNLLGSSPSEQAKDIMQSVCLQDEHIAAVRAPEGGSEQPGMLPRLRKAVDLFRIELFLDKIARLCEDNGAQMGETVGPRRKHVLGDQLVEYLAPYDLEHVASFGSIQRHTYTYRSLYALLLTSVCNLAMVLRQYYGCKFSSPLLSRDDVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT1</accession>
    <name>A0A061DBT1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0203680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767396.1">
        <property type="nucleotide sequence ID" value="XM_012911942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT1"/>
    <dbReference type="STRING" id="5866.A0A061DBT1"/>
    <dbReference type="GeneID" id="24563751"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203680"/>
    <dbReference type="OMA" id="MQVEQVM"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="282"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="442" mass="49635" checksum="C49AB057776E49AC" modified="2014-09-03" version="1">MADDSEPLQDPGDRTPSERPRSPELVDLGDDEEEAQFDRSDDESSPTNNELPPSSNDLSQSNNETTPAADQEEVVEEPVDVTPSQTSSVPEPAPEPDTPESEERPTPKHRRLRKHGSSSREASANVSQEAEQQVDDSIKIPKKKKTQRKKSTSKKSEDQDGDFVPSAGDFSKNHLDADYYDDDEVEERKIPKKKAPSAGKLYFDEVLKRVKERKKKNVQITTEECQHYCRQLIDKMIAAATADVEAVQQGKTGLNKLKMLNDISEFSKPAWRNWCIAEGGAVALASWIAPLPDGSLPTLSVRTKVLQIALQLPFQSTDLRDNDLGRNVVALWKHPDECDSNRVLIRAIVQKWVRPMLGLASNYAEMQQDYSMPMKSSVLSIEGDDKDRKQLQKFSQHKNQMGSIIVNQERINSKLTQMFRVIEARRKTPSKATKVNMDGALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBX9</accession>
    <name>A0A061DBX9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767446.1">
        <property type="nucleotide sequence ID" value="XM_012911992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBX9"/>
    <dbReference type="GeneID" id="24563801"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204180"/>
    <dbReference type="OrthoDB" id="366797at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="633" mass="71662" checksum="6BCF9B71C937BC22" modified="2014-09-03" version="1">MTSIRQYMRLNVAFAFCLYISTINCMAMVVPGRGDISNTATPPATGLALYAGNADFCRKIKILETLSQPDTQLCGYLNFMLLVMQNSNDSPKIKDENTNECHKIIQDLQNMNNAHVYFGEMKHLLNEYRGITRRLQRGRMTSERLEQLRSSLTNLEERFKIREDSASEIAKFDHAPYYRRLAKKAQYCIKKHTHRTPTEADDPRSSFIIFGNPPPVEADLQRRVGGLPTVLPQHIPASVAGNEKMRRLLNDGSLLITLGKVQSDVKKIEAIIHDPLLNDTNVCATDGSSHPRNAMILKIQDQYDGNCDSFTDVTNAWNIYRRYDDINDILKTMVRNSAQAVELIEEQRRLELAFEEYGTIVQNTYLGDIDRIASNMLYMLEKVGYSGETFRDVRSVKEDTPRALIHRVTPLPETNKENDSTSSAETVETIETRTASATTVTNGCSTQQLSDREVSDTANTVSDESIVGKAGRIHCHICKTKRATTSSGALKIGNTITRMMIATLKAPRLPVADRYWYHVLASTLFGNNAHSQCSNNIRESHALSQKYQLVSCLLRERPLSELRQVPVNPHIASLHLHQIFFVNCFYSNDLDYYVLLICQYYVIEVIPSRAECRCVTIKSIVLSTIQIESYYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC27</accession>
    <name>A0A061DC27_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activator protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769748.1">
        <property type="nucleotide sequence ID" value="XM_012914294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC27"/>
    <dbReference type="STRING" id="5866.A0A061DC27"/>
    <dbReference type="GeneID" id="24566103"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400540"/>
    <dbReference type="OMA" id="WESWKVA"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="64"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="414" mass="46939" checksum="A7906DE2681674D7" modified="2014-09-03" version="1">MDQHALCEQGSASSTKRDFVNELLSIGEPFSQLREEKWISMKNRGLAAFAKAHWNTFVRRTNRGIPQKYRWDSWKVALRFDVYAGTLAPKYETFANTTNEYTSIIQIDVPRTFPELKVFDVEAQQQLSRILHAYANYSPEVGYCQGMNFVAGESTSYSRKLLSVPWLCTLPSESVSNTCEIYDDYEGNYHLTTGLLLLVSGFNEVESYVAFVGLMREFGLAEFYMPSFPLIQKYIQAFEALTDDMWPDLHRHFQQEEISVAVFLHQWFLTMFVIILPLRTVVALWDYMLYNGLSSVLAVSLGLQYLLAPQMKQLKFEGIMSFLKNIKDADSKDDIRVGRIIVNQAYRITTTRGCLDSFILAQQAISLTNLPSFEAVGSGDATKRTASSAGRSKPNPLAAIVSQLGLSESPRDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC78</accession>
    <name>A0A061DC78_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768745.1">
        <property type="nucleotide sequence ID" value="XM_012913291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC78"/>
    <dbReference type="GeneID" id="24565100"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304620"/>
    <dbReference type="OrthoDB" id="364836at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="144" mass="16874" checksum="55AD4CE4CD85FC7D" modified="2014-09-03" version="1">MCRNGHTLPEKTRQVIQEALQYCETADRNLKVALIEAEQRVKQAKQEFLELEREAAKVSNTFAATRLSRIMHLTNLIVDKRRVNMSELKPTEMEAIYACFLPYVKQMKVIEMREQEFDLVKQKIEANAETYMLYKNDLETKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCB4</accession>
    <name>A0A061DCB4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767636.1">
        <property type="nucleotide sequence ID" value="XM_012912182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCB4"/>
    <dbReference type="GeneID" id="24563991"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206080"/>
    <dbReference type="OMA" id="WIRDSAT"/>
    <dbReference type="OrthoDB" id="366342at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600266" evidence="1">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="321" mass="35321" checksum="D0644B11806EC443" modified="2014-09-03" version="1">MKLVTSFALLVFSQINLILAAAEEQASAAPAKAENTPSDNINYNDVIPTVEKRFKAVMKLMKGEGFKTELLEKANAEINKVSTQFLSRFTPLLSEGARAASGQVVEPVPSWIRDSATNRVISHQAGAVQNALLQSGKSIHKLFVNLFENFSEQVQSAPVKPEAGKEAENLAQGNTGLTGSVATSETTVAENDQNDEDFLNLRFVMPPFAKDIAALYTLIKDKKQQTVEERNALVEEIKKWLTENVRSVKPKEHMVFETVREVLEKLCGSEKHLADTALSFDAYNHVDSKLAESIERCKNMNAASFGTMGLLLAAVIAFTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM2</accession>
    <name>A0A061DCM2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="10">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0306880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="10"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768970.1">
        <property type="nucleotide sequence ID" value="XM_012913516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM2"/>
    <dbReference type="STRING" id="5866.A0A061DCM2"/>
    <dbReference type="GeneID" id="24565325"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306880"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="10 11">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="240"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="416"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="442"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="519" mass="56470" checksum="1937953A121A78A1" modified="2014-09-03" version="1">MTKRKTYEAERAFIEPYPAARHMYRVRKGFVPGMNVEGYVFANDNLAKLLFQELQQYSTDAGTFLPALKQLANVAALPGIVKGSIALPDAHSGNLPRTSVHCGAGYGFSIGNVAAFDINDPDAVVSPGGVGFDINCGVRLLRTNLTLKDVEPVKEQLVQSMFDHIPVGVGSQGMIPCTNAALNEILEYGMDWTVMQGYSWAEDKEHCEEFGRMIQADATTVSSRAKKRGLPQMGTLGAGNHYAEIQVVEEIYDKYAAKVMGIDQVNQICVMIHSGSRGLGHQVATDALIDMEASPSASSIKVLDKQLSCAKINSDEGIKYLKAMAAASNYAWVNRSAITFLMRQAFSKTFGQTPDDLDMHLIYDVSHNIAKVEEHMVDGKCKTLLVHRKGSTRAFGPLHPLVPADYQLVGQPVLVGGTMGTCSYVLTGTELAMDLTFGSTCHGAGRALSRNKSRHTLDYKDVLNNLYEKGISIRVASPNLISEEAPESYKDVTEVVQTCHEAGISKKCVKLRPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCP5</accession>
    <name>A0A061DCP5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770108.1">
        <property type="nucleotide sequence ID" value="XM_012914654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCP5"/>
    <dbReference type="GeneID" id="24566463"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404100"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="232" mass="26415" checksum="5C76359FF530FD69" modified="2014-09-03" version="1">MRVLCRVFAYVNNELQPTHSSFLIFLTIVLSYACEYDTRESVICAFHRLCDLVGVCRHRDPAYSRRADMAGNTPQYLSNILHRYTIIALPLMRLPAAVRQLRLHVSPSQLVHDKQLRWAAALIFTMSWATRVAPVTCAALRQLPELWTGALAPISSYPSQFIAIHAPLAKQVQLAHGGDSLPTIGSPSCYLPLGVCTPLLTRTWDTNMRRRTYRSRKRKRFIRVGERILRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCS1</accession>
    <name>A0A061DCS1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MORN repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770153.1">
        <property type="nucleotide sequence ID" value="XM_012914699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCS1"/>
    <dbReference type="STRING" id="5866.A0A061DCS1"/>
    <dbReference type="GeneID" id="24566508"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404540"/>
    <dbReference type="OMA" id="DNTQDDQ"/>
    <dbReference type="OrthoDB" id="203073at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="353" mass="38490" checksum="13E5FF8FEEC49876" modified="2014-09-03" version="1">MGSGNGVLGCLRCHGRRAVDEKRVRSSVVENGSPKPQATARPIQPEPDVTPVKEEPVPAESPKGFELTGFVSNDAGEWDDKALASLLGGQPTKLDELSDVDAGAGPVQRVPVVLRDGSVYSGQWLGRARHGMGKHFAMDGSRYVGSFANDLYEGEGEVKYINGDSFRGIFKGGMRNGKGVMTYANGDMFDGNWRNNVRHGFGVERFADGSVYMGMFNNNKREGVGELKMSNGVLYEGTFDNDVTGKGRMVWPTGESYVGEFKNGYKHRYGVTTYRSGPVLSEKGTYAMGRMHGLFECVMRDGHVLRFMYKNGKLMEDVTNKKKAGKLMAPPPVPEVEAGGLVLVDELPDNKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCT2</accession>
    <name>A0A061DCT2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0307730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769055.1">
        <property type="nucleotide sequence ID" value="XM_012913601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCT2"/>
    <dbReference type="STRING" id="5866.A0A061DCT2"/>
    <dbReference type="GeneID" id="24565410"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307730"/>
    <dbReference type="OMA" id="YNDMMPL"/>
    <dbReference type="OrthoDB" id="359787at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="153"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="612" mass="68480" checksum="0F3128EFD2190CB2" modified="2014-09-03" version="1">MNLLGHGAGADNQGNGFLKLRQAAAVRRSSRSGHSDGQVPPHLLANAAAAADHAYARTASNTARTARAGAITERDIDMAAAETFREGIRARDVTDGGILRGCDLIGDIESELSHSVDDSLDLGLSSSCRLDAAESNYFRDPENNGIRNITDVLSFDKRLGQGVYGDVFLCHLRADRTKRFAVKRIQQAPSPVEKIFGLDQNIIKELHALRALKRPHANIVRLYDFCSAMETLVPRNSSKPSPKDAKKKCVAFYLIFELCDMDLSQFVKEASLKYKAHEMDLFSTTSEHVDGEYHIEDIINQWCTLYLKKRQDDAFKDGGPGIAVRSERIPLPGLPEDIVKVIMYQMLQGLAYIHSNRIIHRDIKPQNILLKKTNGVFDSLEALKSPSAWQVKIGDLGLSTIVPARYLTTMTEEVVTLLYRPPELLLGDCKYTTAVDIWSTAASVGECLLGKPMFRARTEFSVLMRIICTVGAPLVDEMPDFAKQLKYLTDSMPKVTRDARSSLRKMFTDHFGRQLLSETGLDLFVKMLQFVPDKRITAEQALKHPWFDDIESLLKPSIAKSYHSLERAFPKGQRDMLPLPFKGDLAEFKTQLRKATLKPASIDEPYMQFVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCU4</accession>
    <name>A0A061DCU4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine aminopeptidase I, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0404920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770193.1">
        <property type="nucleotide sequence ID" value="XM_012914739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCU4"/>
    <dbReference type="STRING" id="5866.A0A061DCU4"/>
    <dbReference type="GeneID" id="24566548"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404920"/>
    <dbReference type="OMA" id="CETYMVM"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="212"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="488"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR98007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="662" mass="74065" checksum="C5E628E3985CB962" modified="2014-09-03" version="1">MNIPLFGIAATFTGLAFRDAVPGETAAVSAAHVAVNRPLWTPKPAFGVTNAASIAFLGHIADEGRGGGGRCFRRRECGVTQTASCRPKRPADIASQKHVLEKERYIRRQAPKGFGDPKTQTPEPVSNKSKEVLQELKKDYPSATIKQIWDIYSYTGPIKKGVVSGRLLPAKGVERPNYYKSGIPTYVEYPRDSDYRGQDDPRGTIKNAQEIEGIRKACRIAREILDSINPLVVEGVFTDDIDRLVHKMARIKGVYPSPLNYHGFPKSVCTSVNEIACHGIPDSTVLSAGDLLNVDVTVYADGFHGDVSETFIVLPAKDPKRVANRKTEIGMYERNKMRYHASLHDNVWDAGATIMMQLNLLQALDAAVRRLQVNDGWGEWFEYLYTDDTDRKPLFLSNKEDDFKRIGTRVAMDVETLYNTVNQESSYDGRIVGIPATQIPTTISPPGQPKKFTTIPNPDIIRHIFQKADPNRHLKPYLFSHTFEDDVALMKVAYDALMRAIQICAPGVRVNEIGRVIREWVEANNCNVLPNLVGHGIGRNFHENPIIHHADNESDVIMEPGMVFTIEPIVTRSRHEECVTWPDGWTMATRDGKKTAQFEHTILITDNGHEILTKRLPSSPNRKDLNKDRKSESCSKGDKNVQAFFVFADVATTKRLSLTIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI3</accession>
    <name>A0A061DDI3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769620.1">
        <property type="nucleotide sequence ID" value="XM_012914166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI3"/>
    <dbReference type="GeneID" id="24565975"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313360"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="6525" checksum="983606DEA79C2556" modified="2014-09-03" version="1">MDYDVCASKLLRSAVKRDAEGYLAYEEIADVAAHRKAEDAQVEQDDGDDDGNDDGGDGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI9</accession>
    <name>A0A061DDI9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malate:quinone oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0301940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768476.1">
        <property type="nucleotide sequence ID" value="XM_012913022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI9"/>
    <dbReference type="STRING" id="5866.A0A061DDI9"/>
    <dbReference type="GeneID" id="24564831"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301940"/>
    <dbReference type="OMA" id="NFLFEVP"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008924">
        <property type="term" value="F:L-malate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006231">
        <property type="entry name" value="MQO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF2">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06039">
        <property type="entry name" value="Mqo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="489" mass="54260" checksum="7048B24732E6F5AB" modified="2014-09-03" version="1">MRSCRVNSGILSISRSLYGTSGVAPGYYQISRRLASSGAVRQSSSNEFDVVIVGGVSGISNKHHLLADIKRIALCERRSGYALVASHLKNNSQTIHCGDIETNYTPETAVKVKRSANMLRNCLTKIPENDLYNIARKGQKMVIGVGDSECQYIKDRYAPFKQIFPTLQLLDKNQVHQVEPNVVRGLKGGMRPEDVNALYVNDELTTCNFMALSEHFVKAANHDGKELQPMLNTEVKNVTREGSTYKVTTNNGTLSAKFVVFSACGYSLLFAQRMGIGLEYSVLPVAGSFYFAPNVLQGKVYTVQNPALPFAAVHGDPDIGANNETRFGPTALPLPLLERYNMRSLPDFLRVLRLDTRVMAVYLNLLGDRTIRNYMLRNFLFEVPLLSRLLFLKDARKIVPSLTLKDLRYSVGYGGVRPQLVDKVNKKLLLGQSKLSNGEGCIYNITASPGATTCVSNAEIDMREICAYIGATIDENKLKQHYFEGEYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS2</accession>
    <name>A0A061DDS2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0304240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768706.1">
        <property type="nucleotide sequence ID" value="XM_012913252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS2"/>
    <dbReference type="STRING" id="5866.A0A061DDS2"/>
    <dbReference type="GeneID" id="24565061"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304240"/>
    <dbReference type="OMA" id="NHIFAFM"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="203" mass="22973" checksum="E16C526E9FDB6A68" modified="2014-09-03" version="1">MESDSGNCYISRHEKRAAFMDLCRKNCTVVIDCEFDSYENEKEATSLANQLMQSYAFNRRADKPVNLVICGIQEGSHLAEAFKKISGTENWMCTLEYKSLEDMFDPQNVTYLSADAEEVLDDISQEGIYVIGGIVDRNRLKGIALSRARYIGATCKRLPIKEHVQLTQSHVLSITACVSIILNYTANKNWTKALVESIPKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDW4</accession>
    <name>A0A061DDW4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0402330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769930.1">
        <property type="nucleotide sequence ID" value="XM_012914476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDW4"/>
    <dbReference type="STRING" id="5866.A0A061DDW4"/>
    <dbReference type="GeneID" id="24566285"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402330"/>
    <dbReference type="OMA" id="VPFIQNP"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="32"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="288" mass="32001" checksum="04E4A5AB27F0098D" modified="2014-09-03" version="1">MSTELPKILRGIAGAGSALLLAGGGAAAAYNSLYNVEAGHRALVYNRLTGVGEAMVGEGTHFLIPWLERPIIYDVRTRPRTLTSLTGSRDLQMVNITCRVLSRPDERRLRDVYRSLGRDYDEKVLPSIINEVLKSVVAQYNASQLITQREVVSKSVRDQLVQRARDFNILLDDVSLTHVSFSPEYEKAVEAKQVAQQQAERSKYVVLKAKEEKKSTIIKAQGESEAAKLVRCRNLCFNLCQIGSAIKDNPAFITLRRIETAKEIADILSKSQNRVMLNSDSLLVSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE48</accession>
    <name>A0A061DE48_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770165.1">
        <property type="nucleotide sequence ID" value="XM_012914711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE48"/>
    <dbReference type="GeneID" id="24566520"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404660"/>
    <dbReference type="OrthoDB" id="366407at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596260" description="6-Cys domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52460" checksum="8910F1506956E271" modified="2014-09-03" version="1">MNLLSKHCIAASVLAGCLVSGIVIDLASDVLPDCVEVFYGTFPNGGIYRFIRGTDEMITGLHYDGHYSHRFSKMIENLVYSHVEDFRRGEEHYVRYYIGRKLKGRVIMRSITEQRLGLGVIRKTTSQLETFIGGVLLLIVDATAGLPQHPLIHTFRPPSTNGSVRYKVKSYFATNNGLTVNIHLRIYNMGEIHLSQINGISLGCKCRFFMESNVIVSYIDDRYFYILTDTKDLQVDVTDMLERNVSDACITSPTSSGSVCFKGSEGGTASFDVSSQEVSDANGLMEVNEATPGAAHMATRSIYVLVPTQLGYEPHFEEYATYDPSSNTVTYDIDFLTTHYAPQCEGEARTYIRMRAVRAVVRSDSTCVFFCAASTDAPIDSRDDAQPTESVSTSTDDANDLVDMDNFIEQMMLPGMDTISDLLNASGIPIDDAEDFELSDLQPTIGDERPALYQSAESSYDTLWAIYDGAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE90</accession>
    <name>A0A061DE90_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770260.1">
        <property type="nucleotide sequence ID" value="XM_012914806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE90"/>
    <dbReference type="STRING" id="5866.A0A061DE90"/>
    <dbReference type="GeneID" id="24566615"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405590"/>
    <dbReference type="OMA" id="WILGNLM"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="421" mass="46815" checksum="8C31AE8D90B992D4" modified="2014-09-03" version="1">MVRDFVIGCVGKPSSGKSTFFNAVCINPNAKTAAHPFTTIEPNHGVAFFTTDCPCVKYNVTCAPSFGSCRDGVRKVPVKLLDVAGLIPGANEGRGIGNKFLDDLRHADVLMHIIDVSGRTNEKGDATIGYDPSGDHMWLVEEIELWIFNNLQPKWAPMARRHAMKKDNAVTTLHGKVSGYMATEALVSKVLDIMEVKHSQFVDLSQWDEKEIRRFVSVFVQERFKFVLVLNKVDSEGDTDENCLKICQRHPDVPSVMCSALAMCFLRKMQAQGYIDYFEGDNDFYMNGDDADDPRNKVLKQVDDKLRHRLRNIRDLVLYRFGSTGVTKALNEAIKAAGIVCIYPVKSLKTFGDDDDSTKAFRTCMTVMPGTSVRDFANMLGPEIGRNFCKAVGVSGMQLAEDKVLTEEDSVLSIVTKAIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEF6</accession>
    <name>A0A061DEF6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">METHYLTRANSFERASE-RELATED, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0310980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769381.1">
        <property type="nucleotide sequence ID" value="XM_012913927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEF6"/>
    <dbReference type="STRING" id="5866.A0A061DEF6"/>
    <dbReference type="GeneID" id="24565736"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310980"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="11">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="205"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="281" mass="32019" checksum="9A54440BCB0EE8CA" modified="2014-09-03" version="1">MATRPEHLAPPEIYYNSEEARRYTVNTHIRDIQVEMSQRATEMLLLPEDECCLVLDIGCGSGLSGSVLNDHNNFWIGIDISAFMLEEAVRNECDKEGDMILGDIGEPMNFKPQSFDGAISISALQWLCVANKSSHDPYKRLLTFFKWLYRSLNYGARAAIQFYPENAEQIEMITSAATRCNFGGGLVVDFPESTKAKKYYLCIWAGMTGIPQKMPQALMDVESDEEETVKTGGGMPKRNKRQKKQESLRQRIINKKQQQRRRGIETRPDTKYTGRARPGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEI7</accession>
    <name>A0A061DEI7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIP18 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0312530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769536.1">
        <property type="nucleotide sequence ID" value="XM_012914082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEI7"/>
    <dbReference type="STRING" id="5866.A0A061DEI7"/>
    <dbReference type="GeneID" id="24565891"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312530"/>
    <dbReference type="OMA" id="HSTKSCI"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="199" mass="22633" checksum="79DAE1B4C47CBA6F" modified="2014-09-03" version="1">MDNVNPVLYKKTNGPSTIESQERFILSKKATSYFYIDHHMALDSDEEAKAEDKAANSLFQPTTGFEPFEVQEIFDIIRDIKDPEYSYTLENLKVLEEHNIHIDNDNSIVTVHFTPTVPHCSQATVIGLMIYVKLRQSLPPRFKIDVQIAEGSHNNEKAINKQLLDKERVAAALENPVLLELINDGIYYNSLSQNGLINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEL6</accession>
    <name>A0A061DEL6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769681.1">
        <property type="nucleotide sequence ID" value="XM_012914227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566036"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313970"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1737"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1799" mass="201163" checksum="8CAB305DD6E370EC" modified="2014-09-03" version="1">MTSINHPNNLCLVTLPFPSSTSCHCPDHVPPRELDKKFDKIQNLKNTSNNNPTNILNNLCTGLETFLGFDSTSKGYTGKGIVYSDLDRLCDGVMGFLSGVLEGVKDDNNVHHYDTNNRSNDIHALIGTIYTCIGKGQKGLQTAVAEVVNWYGTYQNNVDMKTNYVTDRLTTIYTEHLTNPQKGFKKALESLKNANNTTANEVSAALHKCIKQAKKLESTTLENTIQSVKVVDRDLKKRLQEHFDKVEMFVRVFAASAQNNDLLDVLSKLDEALKQLPGHVETQIKTQGHNAVEEFKSTMEALHGEIATMKRGEFEALKVSVEKDLFEAFVDVRKGIDKLEENYGKVIVPGVEGILGQARELKETIIGEKEKFALQVKALSEQMAALQNIYRDITAEVPKDFDAYNSRGGDWGVNQSHEIDALIQQIETNVKTHIREMLGDISSDVKSILNGDAEDDNEEDGLEGMKRKVHGYVQKFDENGFQIVVQSWIEHTLENNEVVKKKIAKWIGTYSMDYFKPGIIDTSTKAILKGQCNKIAIAITKRLQNLIGNAFQPVKIVDQADIVGNVSKVHSCINTFAERLNERIETENFDDTSNAFISSIAEAIEFEAVNPLRGPPLRSPLTVAIQFILTGLVSAASKAAKELYNFALQTGSSKLNFATNAKNAWVMATALDDDLEKAIKKAQGIQEEDHGNTILAQVTAIKEKATFGEFNKKLATVLHEACIKGLGKAQSKVSSMVSERFEPIRKVFAELLDESESTITSLGAFKGMSKLKGDAEQLCEKIAMFLSDTVGKTDRDTEAKSGTLYRELNDLLTHVKELGRKFNDVKKKCRAVDETLTQWTSKAAEQLSSAKLKANHAINKVANEMKNKITDDLHAVIQKVQNVYQRTMETKLEELKSDVDAQFDKIRIVINDDLESGVKGLLRKLHTNCERIVANDVSVEALSSAFQTVIGPLKDHVDIEVKRLNKESNDKSNPVKHHNAKYADELNQVYRVLRDLLNHITTKKGYDYLFPRLLDELMNAVNRLTPQDFADPNTAILDGIRVGLVGFVNEMRKVYINMYDGATPIDKWETEDPKKKKKEANKDAAENMILTKDGRNGARICVTIMYMIYQQLHELYYFGGKKWKDHKIQGEADRIELERHLRRVGYDVSNLITKDGTGWNVAVRLAKGFVRHNEFNKYPTEFKSLDASMGFAKNHGGLLTQIFEHLETYNAVSHMVLQPKPRSPCNAYEMCIWLTGLPYRPVYDAMLHDVLPSLLENPDKQAKDDDGLEIPLVDSGIEPVTAYPHDITYDGLVTSLHEMCSKSYDVLACIVGTGDAATYYACQYCDNSFNLRYPSDPASCLDMLLDILRRLLPALRFLSTQCSLDAEHGGWQQCEYGKVVPSGKSRCKDHSSDEATCQPKCKANTKANCQPTSPLQSYLNDCLPGHLPHQLADIGCKSKCTTCPAGKPGMPCVTPLGFRAFSGSTKTGKAICDILEDLLKNNVASLLSCLLPRPPSTLAEHFGFALSVVKGWKLGVSADKKGMQSHIESSIDKVSISLYSKPNELTDALSKIYGISQKRNDHSHRVAEPADLSTLSMDQSCMLANEDNVHCGPYLQILCSDSYCYLAKKHSDLYLSWAVDLPWSLYSYLKSLFDSYSSISCQDWGCSRCVDGISCRPGKHGDGYSCRCRSLVRCRGVLSTLYNYGFTFGDAKKLLSDTERRYCRNLYAQLQNVLKSQHFTKLFEECDNFIWTIREPFTYLVLALWSLSLFYLICVMVGRLDVLHIRSHLRIPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEM0</accession>
    <name>A0A061DEM0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">-UPF0667 protein C1orf55 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769701.1">
        <property type="nucleotide sequence ID" value="XM_012914247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEM0"/>
    <dbReference type="STRING" id="5866.A0A061DEM0"/>
    <dbReference type="GeneID" id="24566056"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400110"/>
    <dbReference type="OMA" id="CRNLQGQ"/>
    <dbReference type="OrthoDB" id="365631at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="2">
        <location>
            <begin position="144"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="29980" checksum="A11E6CE570C00B0F" modified="2014-09-03" version="1">MSTYLVCLPNGVTRSLWVDYEALCESVGSREALCLHSCAQGDPCRRSVPCLSSDIFPSLIEQNFGIGRESSRLSIRGGIRTKVAVDPHATIDPSRTLTGASSQAESDCRGDYAQNSYDTELCTGPAHQLLKDDVVISVSCRLLGGKGGFGALLKAKGNRKKQSSNVDSCRTLTGERIRHTRLNELAQRQRESTVDPGVARLPLPKEAPEPAVDASTQATHLKHAKKVRKESKRVKSTVVKGLTNSTSVEGQTPTDAERQQLVERALNQCMDVYDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN9</accession>
    <name>A0A061DEN9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769796.1">
        <property type="nucleotide sequence ID" value="XM_012914342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEN9"/>
    <dbReference type="GeneID" id="24566151"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401020"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7018" checksum="F6A74BE22DAF9631" modified="2014-09-03" version="1">MDILSQPIRNTPEHQCSCAAGRASRKTRDASTSEHTTGTLTYPQLKLDNEICRCVTYTFGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYI8</accession>
    <name>A0A061CYI8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bidirectional sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0100400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765897.1">
        <property type="nucleotide sequence ID" value="XM_012910443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYI8"/>
    <dbReference type="STRING" id="5866.A0A061CYI8"/>
    <dbReference type="GeneID" id="24562252"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100400"/>
    <dbReference type="OMA" id="FRWIFES"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF30">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595578" evidence="12">
        <location>
            <begin position="24"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR93711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="444" mass="47796" checksum="358F51D34ADCBB4C" modified="2014-09-03" version="1">MSRCRRLVYLLLINIAATNLVESQQKVLQNTGNPESAAVLDKPVSDNAHTSPQAESDALRPITSTVTIRDATLVDGRAADAAPNATQQATPPADGTANGGADAQTATPVDGTTKEAVDTPAAVETIAKEKGDEQPGPAVNANDNAAVPTAHPGETAEATTHDADAYISGAKVLMAQQPEGAVASAYNGEAMSQERGFFRDLVQGILEIIQTDFNFLISSGTIFSSLLTQLIPLHTVMTIRWNKSTGSLKTLNFVTVAFANFLWSLYGVLSYNMVIILSSLPGLLLNCCYIMVFHKYCKDGQQKHILHVSYKVFAASCLVLACAYLGVESEPYLKFIGLFGGSIQAFSYIAPLLSIREIMKNKSTSAMPTEISLANFIGSFFTLCYGFIIWDYIVIAPNFIGMVSGIVQITLLILIPNNEQIVVTEVGILEKQHFKPILKPEVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ04</accession>
    <name>A0A061CZ04_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765869.1">
        <property type="nucleotide sequence ID" value="XM_012910415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ04"/>
    <dbReference type="GeneID" id="24562224"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100120"/>
    <dbReference type="OMA" id="HPLISHY"/>
    <dbReference type="OrthoDB" id="360741at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="371" mass="41573" checksum="7C9AB39020CBBFBD" modified="2014-09-03" version="1">MSQAAPVSWLKGIWPRQTEDNQVPKCDTPIVVHYTRYWLPPPIEPSEDSEGDADVAVAVEVVLEPYVLWCCLLRSVTGCKLRFSPSLYDEFVGGAMPAAFVGDSACYGGAPLRQESLLSHLLLNLPTASAEVLEQLSSRFALYEAFKKPDGSAKITSDSQFYHSASSILPVYVEKHLRYAVLFFIWVFPKISQNVTKRIVVNSTPWPYGYYVFNKRSKEIARTCAQCGYSDIAFTIKELALMLRELQRILQNDAPSLNHSAGPVTGWKAPYSQISRYSSAYRATVGYAFTKTDITHSGVEELLALHREFYDLKSYCAVVNRTYNVADLPPPYLCGNTFPVSYFVKEPSACMALLGSVWEHIKSIPQLTIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ50</accession>
    <name>A0A061CZ50_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0102300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766087.1">
        <property type="nucleotide sequence ID" value="XM_012910633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ50"/>
    <dbReference type="STRING" id="5866.A0A061CZ50"/>
    <dbReference type="GeneID" id="24562442"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102300"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000151">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR93901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="569" mass="64319" checksum="8CD9AA7C705D735F" modified="2014-09-03" version="1">MANDEHRLAQFKALRRIGAGRFGEVFQVQHKVTGELYCWKVVAYKGLTEKEKEQLVMEVNVMRDLKHPNIVRYVDRVVDRQKHLLYIIMEYCDSGDLAENMRQFRKHYDKVNEQVIFDIALQLLFALAYCHNSSLGPKQGKILHRDLKPQNIFLHSNYRNKTRNGYICKIGDFGLCRSIGLESFAHSCVGTPYYWCPELLLSHSKNYDDKMDMWALGVVLYELSYGKTPFHKATTLAELAQQMKNGVPLPLRGRSRQLNTLLYALLQRDPARRASAIQCLGLPIWDGPVSDWFWDTVNPRDRERIYDNIIRRNMQRLPVSSHMLSEFAGSDSSQICTPKPRKIGRLDARISTEFVESDDEDSHILGMASTPCDDINMDASSVSHSFPAAGPHRAVDIAFSHPGLVDEETPDEFDCIEAHLSTCQEDYGALRSTERRSDSGHPVQDSQTLELPDNPFRRAMSKPQYDAPGTPHMYVRTPTQVRGMDRFGSRAEEATVYTRATEASLSADSQASTCVRRPALYRPIFGSGAGSSSSFGVGSPHTLPSDVPPPVGGSTICSRRKYLRENNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ92</accession>
    <name>A0A061CZ92_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0100770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765934.1">
        <property type="nucleotide sequence ID" value="XM_012910480.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061CZ92"/>
    <dbReference type="GeneID" id="24562289"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100770"/>
    <dbReference type="OMA" id="DAMTMSK"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1319" mass="147561" checksum="2B7045EE7BD7B3CC" modified="2014-09-03" version="1">MYFDGSIAPKRVVSLSGASAFGRTNTLGRSQPGFLRLQQEQDRACRTIVPFLRHVVDVKRAVLRWRELLPQLLARSTEYVDKISLPPANYWNDRQSKLCDNGQFVWGDGANFGGGAGISLELHGESGGVPQPGCATADSVTYHPVCQLMRAVAALARVDWRNDYSHYVRLCLAHFRRWYFSDQHDDATRAMISDRAQLAQLVRLFLNFFRILFRSKKRNLANSGAHASPANSAAYGTAYTSFGTGQGAIATQRGPPYAQGFGLASLGRSGTTGYAYGTLGKPSGLFSHGSFRSGVDSRTWTYKAEEDDFDLNLTLNNSIDDMEVVTARLSFDEAEIVHFVSALFRLVSRSQAQELNDEFGIATEWYPAMVGRALANLEYDSHALLALLEIATPLRDLCTTKESALRMFVNVWVVPNLVKTNYDVKLLRCAFNATFNSAFLQGLCFIGCQVKDDQPYGATSNTRNTVPVGTGSPDRVTTIVRNLTRMAGTKSRKAVSLHHDKCKAFEQNLRMQVESFLGASDLMMLIRKVKLDSGTHDSSLMERIEKSVNSQYARDSGVPENVEPFPYVRLGSPHSAGPSLLAHTDSSQNPTFTNGFAGHSIFTNLCNLLKLLSDRKHGYHDKDTIASILSVTLFCAQLLPVPELEAAGLWKFDSTEVFAHLLHTYRKDTYIVMAITLLLVPVVKWDYFVTDPDAVAIANAARAADSIANPPVDDFDHDSYRSVWERATKLLFTWEIMKTMLTQFKRHHANCCGGSFNQFGMIATPELSNDGALCCLWRAFATVLEHCMLVMNDTELVGDDDEPGLFDADDVAFLVAALNHTSWYHTPYSHVTEEMGNYGRCLNFPENSVCSCGIEVKVNALFHHTKGHGSFTAEYWGKLAYNFNLRFLRQSDGSHSPSVITEVDRLVLNKVRTKQFKAPILKFVHCIPQTVTFETRLQLFMAYVAYDKSMNRANVNISESVMYIIRRSHIVEDGLSTLGTMGSTLLKQIFRVIFVDETGVREEGVDGGGLFKEFLTSICSIIFNPAYGIFEESQFDGSMAPSPNSAMFHEGHLSVFNFVGKVIGKALYEHILIEPVLSRLLLNFILKKRNTLNDLRFVDPELYRNLVRMRKMTSQEIESMGLTFTTTISSLGNSSPVEIMKGGSDMVVTKENLNLFLFMLADFKCNTMIEKQSSAFLQGISSVIPLDWLRMFSYSELVYLMSGSSEAINLADMRANTTYSAGYTETSEVIVWFWEIMDEFDDDQRRMFLWFVTCCKRGPLMGFGQLQPPFCITRDRNTDNLPTASTCINLLKLPEYESKEVLRAKLLDAMTMSKGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZU2</accession>
    <name>A0A061CZU2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766119.1">
        <property type="nucleotide sequence ID" value="XM_012910665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZU2"/>
    <dbReference type="STRING" id="5866.A0A061CZU2"/>
    <dbReference type="GeneID" id="24562474"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102610"/>
    <dbReference type="OMA" id="KCCQSAV"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="135"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="523" mass="59480" checksum="910C45264087246E" modified="2014-09-03" version="1">MAEIKELGLNNSANAPKKGQAAEPRPTQPPAQEESTSLISMLDIFGFGTRSVLGRPAAYGMVPSMPQCECLRIAVNPPGVPEKPIKNAMNKPIPRYTKGERCARFNHWWLKCCQSAVLRKAGVYWNVVQLLENKIVVEGVKMTVADLVLGQKTTTAITLDIRRTYPSLRFYTRYGRLMLRRILMAYAFFDPEVGYVQGLNFVVANLLWHCVEEQAFWAFISLMYMYDCRCMYLQGLPGVFRRCDVIEKCMETHVPGLIEHLRKIGVHIPMIASDWLMTLCANSIPIRPLGRLWDFFFAEGWIAIFRFVLFRLKQLEPYLLTMQDVADVMKVIKYGHAKQAEAWSFIELIPGFGPTMENKGMKLVKSAYYSNCENLTNDPNKNCNNRDWMEIVVGSLKFNLTADVIDKLEQQTTDELYFECATAHKLFPNEEADCKSEGLVSHASSENDVHENVLDRDSQSAEECSRLPPNIANDKSPYETLRMHGFEDIATKLEQLAEAFQKQLADIGVSNAYALHLKALRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0C5</accession>
    <name>A0A061D0C5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U1 snRNP, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0104370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766314.1">
        <property type="nucleotide sequence ID" value="XM_012910860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0C5"/>
    <dbReference type="STRING" id="5866.A0A061D0C5"/>
    <dbReference type="GeneID" id="24562669"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104370"/>
    <dbReference type="OMA" id="PPKFYDG"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000132">
        <property type="entry name" value="Small nuclear ribonucleoprotein U11/U12 subunit 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="28604" checksum="72519232356EE466" modified="2014-09-03" version="1">MSALGMPPHLLVLFQARPPLEYVPPIENGMKRKLNGIADFVSHFSNEHIPPPPPFETPHQRADRRKRQKLIEFQNQQRKDREAYDPKYDPALARGSTNPWLTHDPYKTLFVSNIPYEVTEKQLWKEFDVYGRVRRVRMINDRQNRPRGYAFIEYSDDRDMVNAYKRGDGRKISGRRVMVDVERARTVEGWYPRRLGGGRGRSRSKPPKFYDGKPLTVEEVVKETKPVVTYTDDMMDEIEEGQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0N6</accession>
    <name>A0A061D0N6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766547.1">
        <property type="nucleotide sequence ID" value="XM_012911093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0N6"/>
    <dbReference type="GeneID" id="24562902"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106700"/>
    <dbReference type="OrthoDB" id="365648at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595330" evidence="1">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="230" mass="24842" checksum="408FC8D64159987F" modified="2014-09-03" version="1">MTHTKIPSAVVAALAFVVASRNAAASTNGENRVSVIYVENEGPYEIKCKADENIEVVDAFGICMEDFLSNKLDAKTLNLRLSLSNAFTRYCTALFRANQPCILNINKKKPGPDRFNTTFGLECQHGNVFVGLYSCCAKASTSIAQGEEVVLYKEKSTPLTPLCPSGTKISVLNAGQRGTVMCDKGHITSTLTRASDKCNGKELCSIPFDESQLSSCTGSSASHFVKYICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0X4</accession>
    <name>A0A061D0X4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amine oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0107590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766647.1">
        <property type="nucleotide sequence ID" value="XM_012911193.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D0X4"/>
    <dbReference type="GeneID" id="24563002"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107590"/>
    <dbReference type="OMA" id="CRLPNID"/>
    <dbReference type="OrthoDB" id="406280at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF415">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_56, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1309" mass="147646" checksum="0D429F122EDF7D31" modified="2014-09-03" version="1">MAASGNSRGERKINILRWIFLYHCLTEGQQKELLQSIGEQKQPNYATDRNFTLSVDRPAYVLYYNIALVLRERLFCKYMHLVWNKFGRAVILKLAITETMIRSKDPQLSVDLLHMFRSLDYYRKTTTTYEKVLTIKPGRVNAVFAEMLEHRLSLFMTLGLAPPKDIATLFLSPDRPSQFPYPPNFNFDETMLRLFGTNTEEVVQSDRFKKVRLQGPEGPQVDFPLPWTNGVPTSKEAGLYEPSRPEQTWNMSKIHMALHTDFHPSEVNKKFRNNFNNLVPRETDVVVVGAGIAGLVAASYLKSCGVDVVVLEGRDRVGGRACTTSFPARRCGGKNVPEVNIDLGANYFHCCNVTDAGEGEHRPDAVKDVRARRAHFKSLMGISSEIKPAVADVAGGANWESTVYTRWCDFEGKQIKMESVIKANMIAEKIRVRAARKVQCMKKFMKNPPGNPNPTNSSRHLWYVREGLYREIFNRPPQNTGSMCPEAFDFSSRATASPFPSSHVGYAPLVEDYNPTGIPSVQYAPQYPNMFAHGSDSAVLHGYAPIPNYGAVYAPAGHKPVGVVDKTVSSIPPQSQCTYNGGAPGGVYVEQPYRNWSPPPGCSLPTNQHCTVNKPDYSKNWDAYGVMEKLLKNSPLGVPRHINVKAPCDSNAYLYDEQGNRKSLWDIYIESITEVFQENVLSPQNVTDTEWSMIFVILQSRIGYNSDLRETCISMCRLPNIDEEFDDSLYYLSKENWILNNRYVWQHYTQHTSVNKKPFACQNDSDKLVIDGWDWLLDAISQGVEHDVYLKSTVTDIHVQIGDMEYPVSVQVCGPKGTWHPPKLIRAKYAIIAVPSSMISPFSNGRQYPNQIVLSPPLNSLKSMALLRYKMGHHNKVILRFKEADVFWSAQTPQLNTLDPRFQFINLHMYGKLGCILAHCFPPFSTTWGAVGAEAEIVRQCLEVLRMSFGIDMANMPYPIDAMVTSWYRDPFAMGSYSYPGVNAADDDIIHLKSPHPIEFPRVLFAGEYLSSSYYQCVDGAYDTGMRAAEDVAHLGLCKPYPFPLTADSPSLDGMYNPMMREKYLGIPVPLPEADLLGYYLTDGSDDRITDDEADDRILGNSGLLGDELMVMERARCLLDVDTLHVNSYQRDAKAVIDCMEVLRGRNHWNSPLASLLNILTAVIQASQTPGEHVTGGVMNMRCQSAANAILQKFLALEGVRHDYVCHACLAGGEVIMCDSASCNKVWHEECLPPQLGELVKDTNAQWLCPCCRGMDIQRGQYSVPRALAQYWRRRGVWWCVKALMRHCHTVSRRITFLHKRVSHPKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1B3</accession>
    <name>A0A061D1B3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U5 snRNP-associated subunit, putaitve, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0107320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766609.1">
        <property type="nucleotide sequence ID" value="XM_012911155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1B3"/>
    <dbReference type="STRING" id="5866.A0A061D1B3"/>
    <dbReference type="GeneID" id="24562964"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107320"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="8">
        <location>
            <begin position="53"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="474"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115822" checksum="283F7DAD4D0A2046" modified="2014-09-03" version="1">MSLLPGARKFVPPPASSAPAHYAPGAGRGATAFTTRADFGYAAATASDPFGKPPPGYVPGRGRGATSFAGGVSRDDVADALDRSVVGGEDTVNLENEHLFQDAEYDDEDREADLIYESIDMRMDDRRRSRRESQIKAEVNRQRSEKPTIHQQLAPLKRELEALTMEDWESIPSIGDYSLKRKQQNKRQPQYTAAPDSLLYSARAHMQSDTSIGTSTPLGFATPLGIMGGSATPLGARSVSVMRTPAGTTSSLNDLGEARGAVLSITLDKVMDNLSGQTVVDPKGYLTDLNAMNIKSDSDIADIKKARTLLKSVIATNPTHAPGWIAAARIEELAGKLSSAREIIAQACEKCGDREDVWLEAARLEKPEYAKAVLAKAVRMVPKSVKIWVEAANRESNTNDKRRILRKALEFVPNSVRLWKDAISLEDETNAYIMLKRAVECVPDSVDLWLALARLCPYQEAQKVLNEARKQLPTNPDIWITAAKLEESNGNKPMVEKIIARGLENLTKKGVIHVRSNWLKNAEVCENNSFVATAQAIVKCTMTTGLDPSMYLDSWLQDGEQFEEKGLYGCARAVYRSALDQMKTKKSLWLALAELETKHGSPTDVDDVLTQATKYCPNSEILWLMLAKHKWLQGDVEAARAILADAHSKNQESEAISLAAVKLEREHDEFDRARELLVRARKQCGTRKIWMQSVQLERQLGNYSVAIDMCEEALQLHPYFDKLWMIAGQMRLELPEPNLLEAVGIFKCGTENCPWSTALWLLALEALMRNDEQAKARAMVDMAKTKIRCILGPRLKQSEKVVTVNTKRLSQTELVRIAKAASNHPEGEVTSQEEDQELVDGLVETIMKTCDLLWLRAIDIELECGSATNAHFMISSALQEFPESGCLWARAIFLEEKNAQNSKAVDALNQCPNSPIVVMAAARLFWRDKKTLKARKWFQRALALDDTNGIVWGTFLAFELEGGDSEAIKEVINGCVKAEPNAGYEWCAVVKRVANWRLPWPHKLYRFVEEYHHDILSNALEKLPPDIKSVLIPGEAPVENDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1F9</accession>
    <name>A0A061D1F9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0109340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 13">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766822.1">
        <property type="nucleotide sequence ID" value="XM_012911368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1F9"/>
    <dbReference type="STRING" id="5866.A0A061D1F9"/>
    <dbReference type="GeneID" id="24563177"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109340"/>
    <dbReference type="OMA" id="EGQYGHK"/>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004863">
        <property type="entry name" value="PRK06223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="157"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="322" mass="34797" checksum="06BE07CE64AB07FB" modified="2014-09-03" version="1">MAPVVRRNKISLIGSGNIGGVMAYLAQIQELGDVVLFDIAPTLGAAKALDIMHANTVYDTSQKVIGTTKYEDIADSDVCIITAGLARMPGKKDDEWTRDDLVGPNSKIMTTIGENIKKYAPNAFVICITNPLDVMVKMLLKSTGFPKNKVVGMGGLLDSSRMRHYIADKLNVHPKFVHGWCIGGHGDSMIPLVNHVKVNGLPIQYFIENGQITQADLDAIEKRTIGSGMELVQLYGTGSAYFAPATAAIEMAAAYLQDKKSIIVCSCYLEGEYGHNDVYLGTPAILGANGVEKIITLKLSPEEQAKIDASVKDIRRLEALIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1K4</accession>
    <name>A0A061D1K4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SF-assemblin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0108210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF-assemblin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766709.1">
        <property type="nucleotide sequence ID" value="XM_012911255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1K4"/>
    <dbReference type="GeneID" id="24563064"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108210"/>
    <dbReference type="OMA" id="EHTANDM"/>
    <dbReference type="OrthoDB" id="436841at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008374">
        <property type="entry name" value="SF_assemblin/giardin_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40412">
        <property type="entry name" value="SF-ASSEMBLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40412:SF1">
        <property type="entry name" value="SF-ASSEMBLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06705">
        <property type="entry name" value="SF-assemblin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31701" checksum="455EF0F643F0794B" modified="2014-09-03" version="1">MEDNVVQIADGKPLSAFHSQLKAFELAVAKEGERRKAEEDQKFKHITQQITRLSAELRLEVQERLDAKELLQKTTFEAANRMLNDLQTKLTRRVNSIAERLDALVARCASVEGAVNDLSQRINQSFDFKMLQNDLNELHRNIKNDIAIKVEKDTSLVNKLMHMEYAIKSRLNDIVFLGNESIKELRVEMMRLSEWVSSWQSCLWNVRRIASDVGPMSPQIMEEINTLKTAMELATRARKESDEGLFEAFEQIVRVLPRNIQNEANGMRRINAFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1M0</accession>
    <name>A0A061D1M0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766208.1">
        <property type="nucleotide sequence ID" value="XM_012910754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1M0"/>
    <dbReference type="STRING" id="5866.A0A061D1M0"/>
    <dbReference type="GeneID" id="24562563"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103380"/>
    <dbReference type="OrthoDB" id="365030at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="3">
        <location>
            <begin position="47"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113887" checksum="88C2B0E5955BA7DD" modified="2014-09-03" version="1">MAESGGETPDAQDVAMTYLEQLRMLHSSVLNRQMVRTAAAGDVVDALKQLAELVIWGEKNDFEPLFDYFCEENMMDFLTAVLPNSHFRLVRIQLLQTISMIIHNVVNERMLCKCPNYLLSNNYLNALITHPNMHTGGDVSSWTASLLKTLSGILNQTTIKFFCQEGNETFPLLDEAVKLLSSSDSMKRAHAMTIMLNILRLNDPSVTRYLLDKSHILTQMALYLRYSWRRLNKHVKNATFQSVGQTESILLTQCDDVFQFLMDVMDVGNADVNEALLRRLFSTCFFPLLCSLLRGRDTEASLLDAVDVPELPQCGFFRSAYQQLLTQNGLLGVYATNKSDLFAGTVLRLEADGEAGGTSPTCEGDTASQGGESASTSSTPRSMADFQNMNIPAMLLANEMLPNVAYYLLVTHLASARRDDVRRYILLLTMCPFIPRKVLEHVAFFNVCNSNGEKSAEASADDKAALDAQTADAKVAAVFSCMNAWERHVYGPHSIQLQDGHGQKERSTSGDYVPNLVMGEFVRIGICCVSRNDSRLSMLMALMHSLQNSFMKQAPSPDIAGDFPFEQFIAVPSTAQGLHVVVQGINSVAKHLSSPSLRVQTLSVVLSVALNSIDIIQQYNPSEIASMVDEIRFHLDTGFNELALLIDSELEHCTSLHISVFYDEWLRLEAGVTRRLNILEYPHILLDPERNGSVRRRLRRSDRSLTRSSSLPTIASSAKDGAEPQSKEHVAAAGAARSIYPEVLNEVMTHRTPISLWLFGDWQDRKTTADRASNQRNQQDLVAESRLVKAQKYDTWEVMREPLQLFRRHLQVACLVKDTLEELGSCVPSQDGTTLSPRSRRTAAYDRCPLLKEEQIAINGTPVTLGALVSLEKVRKYPCVMVLDSERKRRFVVCNDTFFLLVREKPHTSLFEATCIHPLWNVEIRRLDVSSRTCSVVIMWYPESKESPREGQSYCEPMRSYSVTAFDIVFNCEEDIVEYARRFNIAVSQLTAACASAIRNYLVPSHQAANGSTASIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1N5</accession>
    <name>A0A061D1N5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">OMP decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0110040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766892.1">
        <property type="nucleotide sequence ID" value="XM_012911438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1N5"/>
    <dbReference type="STRING" id="5866.A0A061D1N5"/>
    <dbReference type="GeneID" id="24563247"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110040"/>
    <dbReference type="OMA" id="QSAFFER"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375:SF1">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="301" mass="32725" checksum="0A9F12F3146F9D69" modified="2014-09-03" version="1">MAFIDKALSRAREVGAPLCLGLDPRDEIVERFSRTGLYTVLYDRYVDGCPMEGFRSRDISSVYVKLKLYCCFVIEATAEHICGVKPNLAFFIAHGAEGIQALMDVCEVIRDMELPLLLDAKLGDIGSTMEYYKKFIFDILNADGCTVNTLLGTDVLSVMGTDSNGQYVNDLFVLARCSNPSSEQIQGAMLSDQTPVYLEVIKCCESFYKANNVTTARLGYVVGATCVGVLAEVRKAYPDCTILMPGVGVQGGDLGAAMKAALNENGGGVIVPISRAIIDMQNPGQAAVYWKEQIRSHLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1X5</accession>
    <name>A0A061D1X5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0104360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766313.1">
        <property type="nucleotide sequence ID" value="XM_012910859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1X5"/>
    <dbReference type="STRING" id="5866.A0A061D1X5"/>
    <dbReference type="GeneID" id="24562668"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104360"/>
    <dbReference type="OMA" id="CDSTDIH"/>
    <dbReference type="OrthoDB" id="365188at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600520" evidence="2">
        <location>
            <begin position="20"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="545" mass="59874" checksum="D2E3BF6E3EE83DBE" modified="2014-09-03" version="1">MWTILITSLSALFLASSTAKDIHRSQKAIFYPRTDGLGTITRGVESLETVQKARANIPATPVVSRIATRKAATGSTIRHNSTPSYAYNSEENEAHVYSNENHSHSELPVSDLRLLKCSSDSFQESVMSPVVGSKCAITSFQGFHALNKGAHVRQVATDDINAPFAIFDSRWTELKGKTELAIPRVSTAVVRRIGNMQPYCAIVPQPNAFSILGNLLASLRLLMLDQKPLQSERPLSLMLMAGASTLPLVVAKLASMPCIMDYLRKRWAFQGECGDLSVEYVLQSMIRILSAESALKLVLRAWFYGRTMQWSNMLPAPAGNVFSRLSQSLSFVPHTVGMLGSSILGGYWNLDVAKSVVHVLVHTAVLTRVAVFTAAQYAFFRDNYHTASFIISPYASQIASVVTGVLCALSSAATVVTLMLFKNLANAVDVEHLLDSAGFRATESQAAATGYARNALHNIPKLFKSVQLDLLVQLTYYHDYLVRLFPRGIEWPVLLLHMTLALNANSAAGLYLALVNLLYSVVNQRLSNYERSILTRDIDAIVQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2K0</accession>
    <name>A0A061D2K0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767192.1">
        <property type="nucleotide sequence ID" value="XM_012911738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2K0"/>
    <dbReference type="GeneID" id="24563547"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201630"/>
    <dbReference type="OMA" id="ERCKECR"/>
    <dbReference type="OrthoDB" id="444121at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="29412" checksum="C840C4FCBECA6EFC" modified="2014-09-03" version="1">MAYLAPRRYAVLADAAGAVGRVFNLSNRRQFSQLACSDTVQPAERPKSLYEATAVPNPTVRGDRLSSEHQPGYQSCRIFDNPNIIEVVREDGRETIGDRIYRYMDIGGTLSMLNSRKFHILRSPAECRKSIMMLTELERKQGIFMNTVISGLMLYVLYYFVQHKRHVYDKPPNVEVVPREFNNNRLKDFTWHGSFFLQYPKGRCKECRWLELECKKRCYDKLLQEGHKFILHEPMQLPRSRLFPSPYPPSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2K9</accession>
    <name>A0A061D2K9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP synthase F1 delta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0106060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766483.1">
        <property type="nucleotide sequence ID" value="XM_012911029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2K9"/>
    <dbReference type="STRING" id="5866.A0A061D2K9"/>
    <dbReference type="GeneID" id="24562838"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106060"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="230" mass="25206" checksum="7C6C705998C0C986" modified="2014-09-03" version="1">MTMIWRRLFGRLPKQLRGVPPLCGTSHISHRSFANTSDAKALEMMDGHGVMGSYAKALYLAAKDASCVDSVMGDLSTLHDAMSTCNEFSVFISNPCLRSSTKVAFLRDDLKTLGLPEMQKETLNCLEVLFTQRRSGDFAELVKLFETLYMATKGQVKCYAHSACELSPKHKVALENALKKRLGGSSQPSVVYKVNPSLMGGLVVRIGDQVIDASVSAKLDRVHSRLSCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2N0</accession>
    <name>A0A061D2N0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767222.1">
        <property type="nucleotide sequence ID" value="XM_012911768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2N0"/>
    <dbReference type="GeneID" id="24563577"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201930"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="326" mass="35736" checksum="E0280AE60FB39644" modified="2014-09-03" version="1">MVYTSLTEAPHNVKEGIDWLMALKGTSGESTLKAMVGALHHLFSKHSAGNNPLPSLDKIKCISKEFLEKPELRDNMLVKKVLEKFNPVDGTANTEFRRYWHRQFDEYGRVVGVKGAEPEYIKDCLSNVMDGFGKLLDDIKNPDQYESAYSAEATWEASCAKNPEDCAVVLVGIAPMLYAGLISLWGTTESKTGEFHRFAGSRSFGEVLRALGYIQPQCRADINGSKLFKNFKGLDDDLLHNTYDLAGFDVFYGSDVVQDGQVEQPVDAAQPVVEEALVAEKSVEPVKAGNSAKGKTSGKSGKHGKSGKSGKHGKSEKSGRRRKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2S4</accession>
    <name>A0A061D2S4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Micro-fibrillar-associated protein 1 C-terminus containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0202330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767262.1">
        <property type="nucleotide sequence ID" value="XM_012911808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2S4"/>
    <dbReference type="STRING" id="5866.A0A061D2S4"/>
    <dbReference type="GeneID" id="24563617"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202330"/>
    <dbReference type="OMA" id="FHNERAG"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="201"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="460" mass="52364" checksum="7DEBA6EBF9F4B2F7" modified="2014-09-03" version="1">MSALELFRFLGEDLNRPPSPSRDALKRRRVSQAPRATRYWPGKAPEYAADLPASSDDESDAAPEVAQAALENDRRYSRYATASESGDVAARSGRRRAPAATIVIDREPEHNADYEAPQPSSPGLAGAAVGDGDGSVANTSEVVEAPRNRAAIRSRAMAYRREEEAVAGDHEDRVASVDGEEEEYSDSDDDADGSEHISIQESKEHSGVLEKPVFVPKNRRLTVLEKQELEREEQRRLECERQRALERQKQSKELLVQTLVAAETQQEVENAVEVVDDTDELTEKEYELWKIRELKRVLRDRDERTAHERLAAEVERRRHMTEEERLADDERIDREKVQRAPRSKMLFLQKYYHKGAFFMDKLDDGSEPLYNRDFNAPTADDRIDKSLMPKSMQVRRGLYGKMGQVKHTHLTAEDTTRFDMPWNKVPEKFTPAGTQQTFDRPSRKKPGTSRSGSDKHSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2T8</accession>
    <name>A0A061D2T8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0107010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766578.1">
        <property type="nucleotide sequence ID" value="XM_012911124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2T8"/>
    <dbReference type="STRING" id="5866.A0A061D2T8"/>
    <dbReference type="GeneID" id="24562933"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107010"/>
    <dbReference type="OMA" id="YHLRTIG"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="642"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="954"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122583" checksum="8325FFE4D6A02849" modified="2014-09-03" version="1">MDQPGFWNEFSKLNLVFEHIKLTGPGIDAAGDHGKGVVAEAFHYLRTLWHPNVCCYTDMLRTAEGTHILVSEGYSLTLDDVIRSYAQSSNAFVSEEVTSGLKFDAIAHQIICGLQYLHAHGIEHGALGPHNIYIHSDGTAKIGCYASHYLHRVASTSNVKANRGNAGTSGTAVRGGATVVKRSTDNTADISGLDSYGSMRCYSSPELLTGACRPTAWMEAVKNDIWALGMTCLQIIGVIIAQEAAVTSRKDSSAVEPQISAVRTYEEMVKISHCTHTPSLQDDAFRVSGSLIRLANERLVGVGDLSAVGINIVGTCAETRTSDDGDHTQQSGEDLLDQLVQKMLDDAAATPVVVHFDLTDEAKSGVGRQRTIESNTTETESQDTQDSAEVGDDSSRRKTIVGVVREILNWYTGKSVVEDLLDFVGIDLRKGRTDPTRENNATVQQVYTIFHIATQCLIIDPIKRPTVMDMLIFQQPKARGGRIYRDSREDTFGWSLISAQRGGAKYSLGLRIPINEFLNRSYRKRYLNIRELDKLELHIDDLFYLWRLMGNDPLDLVEDAQYSNKDKGATYSRQNVPLHELMKICAKADLFPIIIEHQIRPTCAYARQFSFLYQWIRLRRFDKLLHNGLESKYQISTEAQLDIPPMRRKHIWCVLLGLDAPFGLPMSDVEMDEPVQESVAVEITKALKRFDNDILHSRRCVELMAKVGCAIQQDHGLESLPSSLYVTFGPLVVQYYEFSELFMDAAMNIFDKYLKSYYVPSGSFVQNDLEEFNTMLNFFDPEVAAHLQRVGAFADSFALLWFMSLFAETASLQQLNVLWDTMLNFPRNYVKYLAVGVLHSARDGILQTTTAPNAISYISSLIEAVNAPMLNSMCIILYTIWDHILFPKESARAKGIPRFDSIPEKSNALDVGFVATEAGVDGIVDVERAMFTFRADVYPRQRCFKLALKQFAEVFDGCLVVDLRSADAYKLGHIPNSCHIARLLACLEKRDEAVLKSLVRDLVSSNPDNASGLDPNSIRRKHQLGKNCETLLGLGDKAWSQEGLKEACILLAAGDGSDLDKEQDALQRLIFEFHVAHVCYYRINADDWPKLFTLSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D316</accession>
    <name>A0A061D316_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766678.1">
        <property type="nucleotide sequence ID" value="XM_012911224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D316"/>
    <dbReference type="GeneID" id="24563033"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107900"/>
    <dbReference type="OMA" id="YMCWRCD"/>
    <dbReference type="OrthoDB" id="418622at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="114" mass="13197" checksum="D8B4035FF8020993" modified="2014-09-03" version="1">MAKKTEYKKSELLQILSSSTASLKDKNRAVKLLKKFDPNPKKHLDSSFQTSQATVAKYPSLQSFLCWRCDKIKQTMTKVKWESKEGLKVICTTCYTNLAQYLEVAKVRRLNNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D374</accession>
    <name>A0A061D374_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MIF4G domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0203580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767387.1">
        <property type="nucleotide sequence ID" value="XM_012911933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D374"/>
    <dbReference type="STRING" id="5866.A0A061D374"/>
    <dbReference type="GeneID" id="24563742"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203580"/>
    <dbReference type="OMA" id="ICFRIRC"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="723"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1195" mass="133903" checksum="3FDA1BC3F4814AE5" modified="2014-09-03" version="1">MTSTDEQEKAKTAETRTSTFNPDAPVFKPSQPRPSGQLNANAPEFIPGQLGTYDGGIGYVSVPDVKHGKGYNKGGYHRPISYMHPADGQYPPAWSPPHQQYMPLWVPCPQDMYGGAPMYDYVPYRYGGGRGYEGPDGQPRPMRGPRHGTPTVQGHKREASVSHAMGMPPPPHGPPKRVDPVDRRKENKDQGKVSEGKVKAEPKAVTKEPAVRVPEVLVAPIATPPPDAKPKQFTWADRFRQSSVKEEAQDVPKVEESNLTTSIWKGRPTFADMMKKAAEAARKEEEVKIAVAKASEAAQKLEMESESQKSPEKSALGVSPDVASEPARASAALATDERTVDVAEDTLHKTAKAIVAENEVVEVHDETPNHRQPKSEQIPGKDQRIPVNHIDVLLTAERQKGAVEVKPEQHILTKQIPRAEESIPSKDLSEPLPSTPSPAVQPDMSSHSFESNRSEGVTPSNRGVPSSPSVHSHVLDASRFDKMNGVKATTPELSKDEVQSAEYDASLDHYQTLESSPPQSSNELPELSESETSEQWHESRETMRSKQLDDAASSPLVDSGDEVEEPIADASDVSAAVATPSDKLEPEPFAKVKQYSPPPSDLVFPIDTLVRCGFELMRVGLEFNSELVFSLNINRDTNAGTENRRTGGARYEEKNYAQKYKGDNWVMQRRHAKPEQRGFGGWNKSSMEFSRDQLESLSRPQASESSWIRKQAKLKMDKDHQLTRRLMGLLNRLTVEKFDTIYRQVLMSGVETVQQAFMLVKIIFEKAITQHHFIPMYVELCAKLSCDLDNFLAVDPQQGSQSQQDTQSTAAAGERKAAKRSEFMRILLNCCQDSFENNLKPLEFPPELEGDDKFEFELKYKHRMRGNMIFVGELFKQKLLAAKLLITCLDQVFAKRNECIASTGSIDTGDNHLEGMCTLLQTVGKSFDTDKWKYASELERRIQMLTDLGRNPQICFRIRCLIQNVLDSRHEKWVKSTPYKLEGPCRLQELRSKVMEQEKQQEDHAWRTKRRGKSYEVRAPSPRQQSPKSSAAPNVLSATSIPPPMTADELKRRTRGIVREFVMSHDPKEASLCVSELNLQPTRDWELYAYLFSAALEACAKLTADQDRRIVAKWMTDLAIGRSSQDALVKWLHGFLKDEPADHGYSMMIEDYPVVPLMLKELLNCMKESYSNVRGFAEVEKIIEGEIYPAVGLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3H9</accession>
    <name>A0A061D3H9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767462.1">
        <property type="nucleotide sequence ID" value="XM_012912008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3H9"/>
    <dbReference type="GeneID" id="24563817"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204340"/>
    <dbReference type="OMA" id="NDPMITA"/>
    <dbReference type="OrthoDB" id="365288at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="36474" checksum="B8E207B4124A8BDA" modified="2014-09-03" version="1">MSAASGLLYAQKAMFICRVGVCARFAASQRRWELVRQTKNHNANYQVSIPENKAGVSKYVIPSDSGALLVDGRRLTRGERIYQGISIGMSPLEGSNQCLGLPVIAFVAALAVPVGLVTLFAFNGRRRIEKDITKVQQIPHVVEIPSPIKLLAAKELAKLIYVNKPTIVVYYRPGSNDEESNRLNLLFALLTEIAAVEGSPLNVYRVNVQNEFQHFNQHLREEIKQSPTALIHLVIPQEKESMVTAVLPPVSATSFVDHLTKQLGNAGIKFTKDKAATKILDDKLVSIKRCMFDLKIEGEVLFVGGHNFLQLERECNRLMRCSDKLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3V0</accession>
    <name>A0A061D3V0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767434.1">
        <property type="nucleotide sequence ID" value="XM_012911980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3V0"/>
    <dbReference type="STRING" id="5866.A0A061D3V0"/>
    <dbReference type="GeneID" id="24563789"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204060"/>
    <dbReference type="OMA" id="EIYWTSE"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="33329" checksum="A76FBB0A0B1F0B23" modified="2014-09-03" version="1">MAKQRETLCTELREIQLQEDDAVEQFNDRINEIIAQYSDTLNELADKRVKLLTDPTVVDTLAKKRMSEVERCYSELSLTEISGVNRPVDERYQAHGTTAWPMFWLHALMGCYVTKKRVSCLDKRLLGYLRDIRCRTVQVPNPGDTFDVEFHFAENPFFSNATLKRRFNANGYFDETHSSSVAWKDNAEKIAEELPSFNSDDDYEDISDDGLARVSFVDFFQPYGYDPDDLLVAMAIKDRICRDPLKYVLRFESARRGDDVEYTDDEGASVAAETNYDSAGGRYPFSWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D441</accession>
    <name>A0A061D441_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767519.1">
        <property type="nucleotide sequence ID" value="XM_012912065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D441"/>
    <dbReference type="GeneID" id="24563874"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204910"/>
    <dbReference type="OMA" id="FEPCDFN"/>
    <dbReference type="OrthoDB" id="432817at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="66084" checksum="8C251B6569A3ED31" modified="2014-09-03" version="1">MPGISERRQGEFSCTGSLYSRLRFKRSNRMQRLFSYYRFHKRVGKGNWNRYVERYTVPRSIENTQRITFNYRASFQAAKSSASYLWEFPKRIAAATSADGVLDAWIHFRHKRKKAYHFVLALKRLSEAKNVDTSDWRFQLIAKKLLKRSKYFIDLPGICHYLGSLRAVPILDKLSIVLSENIDRYSPPQLAQIAGAFGSCRLSSKHLFSLIARRLENNIQHASNGELATVAMAFGRCAIYNYRLLASISQEVQKRFSPALHVMNSHRDLVSAPSRHCLFSLQQEVTVHAQRPSLADLLQLVSKYRDSQICDIVSQMVRRNMSSLTATDVANPDVHRRIVKAFCSLKINDIPLFLSILDNIASRPYNYTPACVAEIGKHLSLVLPRDADRVSKVELKTSKIQRSQAFGVCLEEVKRHLHRMGRRELCDAAVFAFKACSSIAAKSDFMSEVSTMVVRQCPSNVKYDAPKLMEVLSMHSSLDQECFNLICRDIYRLVDMFEPVDFQRTSRVLRKLKQSGLSNLKMVNMLSKRVAAQWEEFSEYQYHCVARDLTLAGPPFQSLLMDIWNRNKSVYALSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D466</accession>
    <name>A0A061D466_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0111300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767018.1">
        <property type="nucleotide sequence ID" value="XM_012911564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D466"/>
    <dbReference type="GeneID" id="24563373"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111300"/>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10305" checksum="E2F5CA43B4A61819" modified="2014-09-03" version="1">MQPRYFGFLNDSRWRLLLKGAEPTGTAIVRFASEVEAVRALKDFRDVYLRKRKIEATLDFTDFSQRIQRVHKPIAVDRYRLPLRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D484</accession>
    <name>A0A061D484_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767569.1">
        <property type="nucleotide sequence ID" value="XM_012912115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D484"/>
    <dbReference type="GeneID" id="24563924"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205410"/>
    <dbReference type="OMA" id="AIQYEGF"/>
    <dbReference type="OrthoDB" id="363962at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="543" mass="61318" checksum="D3E4F85CAF6CEA53" modified="2014-09-03" version="1">MDITSKSLSDDGNKAMVEINTSQVCRNTHSEGSRRAMDSICAISCGDSIDGATINVNRADVKPVIGQLCAVGGTSISQRLPGLYSGLDDTDHVKGQSDPNAQLNFPGNAIDIKVPTNGTFDLGFTNKKSLEFCFSDYKPGTRNRNPQVSNDSGTVKVMGYGRCISAFYTVVWMSCMLVALLAPALFHVCCQFRLYGGFIPTHDRNVDSDDIKLRGSYIISDARSIVNQLSEFENFFLIGVFLYLLIQIIGFYVTQARIRMYLWRLCEVSVEMAKHDFLYDCKQRAVEHFSDYTKSISRNQTHVCTQTERRLVKAFDEAASNFGNNETGNIWRKTSLMRYRILLTRVYIPIIINLLISIGTSVFVYDRRLRMHHRVPLAHPDIVANFYWYAAIQYEGFWCIFTLMVLNFTTWVYLCYVNLHKTLFGLLEEAHNQIRTVAADYSSKLAKDIWDNQMLLFSSTVCAMDTNKVGRSVTCAPLRVETFNSQINFNTDVANKGGRQCLCRFLCMPSTERGVGIASPFVGGTPFEELHTPLMESGLHRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D497</accession>
    <name>A0A061D497_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0205560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767584.1">
        <property type="nucleotide sequence ID" value="XM_012912130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D497"/>
    <dbReference type="STRING" id="5866.A0A061D497"/>
    <dbReference type="GeneID" id="24563939"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205560"/>
    <dbReference type="OMA" id="NEITHTY"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="301" mass="33882" checksum="C4EA8FF4934D237C" modified="2014-09-03" version="1">MENDASSANTVFAHDFSASHLDLISQNAVADKGVGICVETRRALYSDDLVDPGEDSSGDDTSNEITHTYKETELLSKIKDISTKSDGKALPWVETLDITSEKKCSDELNRNEILKLEEHFKVIASDCAKRGLQRLAKMGFSFNRPSDFYADMVKTDIQMARVVKKLANRSNIIQEKKRRQSMKVKKVFDKQVKQRQMKNKFVKDVDNLIRNGTNNDSIEKQIDRLIDNHSMDERKSKSAGSAMKSQKHLPQRKEKATNKPTKKTKLRNSKVKRDSGGKSIKGLKGNKGKKGNGRGKAHGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4H5</accession>
    <name>A0A061D4H5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766020.1">
        <property type="nucleotide sequence ID" value="XM_012910566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4H5"/>
    <dbReference type="STRING" id="5866.A0A061D4H5"/>
    <dbReference type="GeneID" id="24562375"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101630"/>
    <dbReference type="OMA" id="DAYYSMV"/>
    <dbReference type="OrthoDB" id="361161at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="236" mass="26595" checksum="A3BE9422273E9269" modified="2014-09-03" version="1">MGRSGNSAAYFERTPEVDEFLGEFVRVRTRYLLETARAAKILRSRAAEAPYRRLSELNPVASHEDDVPNDEMIDAAREMEKGKSINLDAFIRLVVSHHELCDSFDDNTNAAIQPRRFELYQIMMNTTIKNRKALKLVDATDLKSALREAEERRYQRLVADVSKKLKRDDKTSRPYRPPIIGGINAIVGVFLVFVGAYSVAGVIGVKDVVKRAVIAAFMASAALLVDTLLFVMRCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Q2</accession>
    <name>A0A061D4Q2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PWI domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0201840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767213.1">
        <property type="nucleotide sequence ID" value="XM_012911759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Q2"/>
    <dbReference type="STRING" id="5866.A0A061D4Q2"/>
    <dbReference type="GeneID" id="24563568"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201840"/>
    <dbReference type="OMA" id="INIMQKC"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="5">
        <location>
            <begin position="419"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57635" checksum="8AF6AEF270E70956" modified="2014-09-03" version="1">MSAPDMNGMMMPPCPPPPGMEISEAAYPAPPAVIAKGPSAPTAPVGYSSNVVPGLIDTLMMPATVALPVQDPEPPPMVNVVYVGGLHSGTSSDFVINIMQKCGKLINFKRHADPSSGLLANFALCEFESPRGAYYAMECLANLPFGDGQVKVSCNDRVRGLVEEWVTEQISGLRDDHPDMSDDELREIFKAPEAELRRSFENLIKYEVRDIQAGGPSAASSRGDVVRAPRRTDHRSDSATTVKNSDAANESQHLTSKEYTVHPKECARRSKFKSRQREKDDIFRREEREWLMEEASLLRKLQRIGTVRRSTRERLVKEDLEGFARSTSSRERDREREMDLEDAREEALELSSSEARCTIPLAAPVVQQPPAEPPKHALPTVFGNAADEDEPIFNRSHRPQIQLGLPDAEIWARVPKDEADVFAYPLDWDRILSDGGLFSSIEPWMRGCVSELMGDDESVVGEVLEFLAGRLVERPGPTELLSDVEQFMDDESQRFVLELWRRLIYHQLRLGEPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4R9</accession>
    <name>A0A061D4R9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0208550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767887.1">
        <property type="nucleotide sequence ID" value="XM_012912433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4R9"/>
    <dbReference type="GeneID" id="24564242"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208550"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="81" mass="8742" checksum="037774597B9876CA" modified="2014-09-03" version="1">MSNSSEGQTMQILTYVGYAVAAIVGTFLLVVACAHIAIQTHPHLINKLRDMYSYLTGSSSSFTATNSINFYDPGQPTLSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4T8</accession>
    <name>A0A061D4T8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0208700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767902.1">
        <property type="nucleotide sequence ID" value="XM_012912448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4T8"/>
    <dbReference type="STRING" id="5866.A0A061D4T8"/>
    <dbReference type="GeneID" id="24564257"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208700"/>
    <dbReference type="OMA" id="ERRGFHD"/>
    <dbReference type="OrthoDB" id="366059at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="27918" checksum="73B8B7AD15BA925D" modified="2014-09-03" version="1">MPNPVEAYRKLQKKREKEKHRKDRQEAREAAKLVQDPDRLKKELDELSHKSIIGRIDDVAAERKAKLEKLWAKHETTIAASAQNIRPPSEPSDKSESDSSSSEDDSDSDEDKPKCVIEIAGGTIISANPKRKVKKEKLPDDFALELLQNAPPLPPKEDSTAAPNKRGTTFPDRDMHMNHAKRRLDVHPPKHIAVNRGMNVAAPPPPPPPPPPSAPPKKPIAIQIPQKADPPKAAAPLSSYFVPNQLRVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4W4</accession>
    <name>A0A061D4W4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767273.1">
        <property type="nucleotide sequence ID" value="XM_012911819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4W4"/>
    <dbReference type="STRING" id="5866.A0A061D4W4"/>
    <dbReference type="GeneID" id="24563628"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202440"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35318" checksum="1B2512440F05B11D" modified="2014-09-03" version="1">MEEDNIEPRELEILPMKLVQTALQKGLLDRAALSGVEASTVKGGKKHTAIRNRKFSRDAVNVLNRAASLFVLYITTVAQDIAKTKKRWDVLTELCTVCRATVYETDILEALKSCLFWEIEREMSEEMVAVNELIKIRQAQILREQKHEADTEIVANDDNNAEAHDAVDKHDEEYHSDLDAAPVDELEGAFDYDQFPEMDATAQVEYTSDEQVTDAIEPEMPEHDGGTHDYDMLGADDHSDAAHGPKLPDYTEDTVMADNGDANHAANTTTSCGGPTQLDDMEVSMEFPDEHTQLVDDDPSQAIETEEMQDASTQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D529</accession>
    <name>A0A061D529_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="1">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0203090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767338.1">
        <property type="nucleotide sequence ID" value="XM_012911884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D529"/>
    <dbReference type="STRING" id="5866.A0A061D529"/>
    <dbReference type="GeneID" id="24563693"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203090"/>
    <dbReference type="OMA" id="THQVSEN"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="481" mass="53906" checksum="A2C02F45A5813A62" modified="2014-09-03" version="1">MYNTEYELVVRLLQHYFGAQVAKVGGAILLRGQVTLQRLLSQPHFDFKSVRNSLIILIHHGFVDYVLQPPQAGGRRSAAVLYSMNCERVLAFPLLPFGCVMAKKELTEACCAILALAAKRGTISQRRLCELCVADLSLRPEDVASSVASLMQAGYLSSCESYRHRLTTAEVTSRGTDPNDPLAAMNSAIYHVMQGAELTGADGPMLRVNSQYVVDRLLKEEIVNLVCRRVGDLPLLRAIMKVLLDNPRKEWPHVVEYTQLESNVLRVLQDEFGKSQSGEQVMRLLSALNKHPDNLVRYEAVTRSYYFDWDKAKGMLRRKTIFGCVRQLCGLKSARVWSLLVSTNEKNSHATFDAHMVSTRALVSMQTARGILYGLTLRGLAKHHETDAVVTTMPATNTSDRHVLSFSSSVESTYLQLMKHSFKFASNLLERLGCERVGVLKSFFTATGKSEEVYSRNLKACDTAEAHLFHVLKFVVLMQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5D4</accession>
    <name>A0A061D5D4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0104880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766365.1">
        <property type="nucleotide sequence ID" value="XM_012910911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5D4"/>
    <dbReference type="STRING" id="5866.A0A061D5D4"/>
    <dbReference type="GeneID" id="24562720"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104880"/>
    <dbReference type="OMA" id="KMCTIQY"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="424" mass="47789" checksum="387EC71D96A52ACD" modified="2014-09-03" version="1">MTLDGFLNSYLCLALVWNTLLVSLVISTHVLLQHLVHYNNHRLQSYVVRIVVFMPIYGALTFLLYLLPSLGNMLEMLRNIWEGLLIHSFLCLLMEYCGGENQCGEIISRDPAVLKHLWPLKEIKAFSFSDDIPLNVGFVKRCRMGTMQYAFVRPILAILSVVFRLTGIDKFTIVAAFNWIAINVSVAVALYALALFYLATKKHPGLAKANCLTKCVSLKMMVVFTFYQGCIISWCTSLERQVAEQLNTVLVLLELPLFAILLQKAYCVEEFIQPLDLDLNLEVPAKPRSEQQEQADVESPQVSEPKCIFDERLLQLCSAIGLDADDLRIAGTAEGMEKIVSNASMALNMTDLLKDLYYNCSDKYRQHSLLSQATVKPTDTESSDKASGSNPSDNVVENFAEFEKEQNKQNMEEKANTLAKLQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5I2</accession>
    <name>A0A061D5I2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA recognition motif (RRM)-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0105330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766410.1">
        <property type="nucleotide sequence ID" value="XM_012910956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5I2"/>
    <dbReference type="STRING" id="5866.A0A061D5I2"/>
    <dbReference type="GeneID" id="24562765"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105330"/>
    <dbReference type="OMA" id="CEYADIC"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="365" mass="40982" checksum="3C2E53468A998E2A" modified="2014-09-03" version="1">MDTYHTSDNSKSELPNNTGTTKRRRRTRESKWDIPDEAPETVGDLADKSANDGQKKRQRRLYVGNLPPDNALDTNGVSPPISKTEIFNVDQGYCFLEFSTAELADMCFKLDGINYKGQTLKIRRPIEYGTTSSSDDTKVFVQNIPPTMSDADIKALLEKHGKLTSANLVKDLKTGQNKGYGFFEFDDSRAAKMAVCHLNGHVVDKHVLSVKHAAFSYFASGGKLTDSKATNLPNSVTQTILSNPLLGLQMQSGRRTGAQPSRVVQLLNIVFHEDLIHDRKYHELKNAIIEEAKKYGHLEDVVIPRPNDDLSYREGVGKVFLKFGDDVSGRRAQYMLNGRVFDRKRVVCAAFFPLERFTRGKYTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Y8</accession>
    <name>A0A061D5Y8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766510.1">
        <property type="nucleotide sequence ID" value="XM_012911056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Y8"/>
    <dbReference type="GeneID" id="24562865"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106330"/>
    <dbReference type="OMA" id="NRMENVT"/>
    <dbReference type="OrthoDB" id="365427at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20253" checksum="ABB2057393CB6076" modified="2014-09-03" version="1">MTPCVSDKKALALLVATNILYFATYVLRLNLLRVLINVGTFAIFLGGVCQMLCNKTLCNDGEDEEKHEFVKSETIAGVLQCAYASINGVCGYIRTVLLWRYPMMSVNALVVLYIVGLFARILSFPVLVFLLVWALCGWLSFREHYYDMVHPQVKPIYEVIGNAARGVYASIPKFKESQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D655</accession>
    <name>A0A061D655_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dephospho-CoA kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0107130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766590.1">
        <property type="nucleotide sequence ID" value="XM_012911136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D655"/>
    <dbReference type="STRING" id="5866.A0A061D655"/>
    <dbReference type="GeneID" id="24562945"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107130"/>
    <dbReference type="OMA" id="RWEMYRA"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="30607" checksum="57C446EC7D315547" modified="2014-09-03" version="1">MVAERTVLSLITSHPGDVLCLMLFAPLALLQSKLQRRRGGKLWTAAVVALLISLETFLYINGRIIVILLSLPLIICSRRMCVPAVTGGIGSGKSTLARVLADNGYTVVDCDAINRELLLPGSPAYASIIRKFGAGIVLDNGEIDRAQLREIVFNNEARRLELNKCLHKYIGLRVIWNIFKYRVLLWRSRVVLDVPLLYNTPLVFVSSPVVVVVSPVESRLERLMSRDGTVPRATLQNIIKAQVSDDVLCAWGDIILDNSQSQEEFVEQVESLISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6E7</accession>
    <name>A0A061D6E7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0300330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768314.1">
        <property type="nucleotide sequence ID" value="XM_012912860.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D6E7"/>
    <dbReference type="GeneID" id="24564669"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300330"/>
    <dbReference type="OMA" id="QMVGGVY"/>
    <dbReference type="OrthoDB" id="366121at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="NOV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="834"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2877" mass="319269" checksum="57E187B7640DB80B" modified="2014-09-03" version="1">MAENPFVQAWPARSDGSYPAPHALQRPLNRPAAALSAGLPKASATHITPSVQIDPGCTPPQVASNDTLSQQCSDTKVGEPSPPIGGAYQSKEPENTDPFSQKSPIQERAPVSATDLEDGAWMKCMEKFNGFNKASVIAQMVGGVYTHLYTDYYVVHSQSENCRMVDMLFFNCSCPKVTFPCSHIMAAALAFNNRRYVGKVVLMKNIEQHVIKVLHKSKSKHATESVVSAIAAKVKTLCNNAQEEGMLLELLLGVVVRLFQVAYGLVPHDADIMGRSKSRYIERMGTGCWTGDAGGSDKPSAAHTAPESSQVLANLEKSDNNATSTTNVECSCDLTPDKSVEFLSRQLLGRFGFLMEDIGPLPEPSNEQDMVQNITSMVPMFRRILEEDYGINARSKKGHKALRKTISNALENHCKDQKVSPIVDGYALGYDYIERRKPPSQLMRAEDDPKSAVKMRELYDQIIASPMMADIHRVTKWSVTHQMNHGTLKGVLENFPLDVLGDMMFITLKNDSAIKVPSPKGFASPCDILQVMISAINNNDPRSFCAHGLTLLVSVKKISLLPPMSALTNAVNSLFLSQSLNVPGALFVAECIGLMPEMLILPFCSAYFDNTDAFGNKSMRHVAIHMYNLITKGRMSDSVREKLLLIGSFFNIPASVYCEKAKGILATSGTGCEEAPKVSNEQTAKYKSLKTVNKGSCTPSPIVYSAALPRADVRDAVIPEVQQTTQVSSICAAPDYKSSETYCALDNKQGPVTVSPSVSVNVENAHHNKAENEQVSAYVLLDQVDKWPTMKFSLAQEKRYVDLIVEKAHDTDNGGIDTIPKPEKGVPTRGHNITPSTPKTGGTPGVTASDAAHLHSQLWGTTDPELATRGKMLIRDIRYQEFGLAMNPQPGDNKSSQTPDNRHIAAVLSKQRQKIARSIERLAEDLYINRTHFQLELLQNADDNDYDVESPEIAFLLDQGGIVVINNERGFSEKDVRSICDIGASSKIGSNESKTGKFGIGFKSVFLVTQSPYVFSNGYHFMFSTNPNMLYNTDYILPHWVSLGKKNNPFGYVRTMLSDPGDTVYSAFVSQFVQRHGAIPNTLMYLPFKEDVASGKHGFFSDFQQLYPLHLAFLRKLTTITLVDITQCTVTRISKKMLVRKNVRMVVNSQAQPEVSLTTASSVVLPVNMLDARFQAIMISTEVGNIFNNISTVQDTCVCMLTHNFMLGKIERLSVGLSKKSSKGCAVTVGLPLLPDVVGGKTYSVYNVLPVADYGVPFMVNADFVLSASRQNIIGGDPWNIMLTKRAGEAFALMVLIISKAFRHLPNVYRNVLYAIPGKYAGTGGFEMCCAEARQLLQHMPWVAVEGESNLTVRPSNAVIPPDNTCLMSQKDAREITRAVFDPQLLKDCCDTYYASVEFHDPYLRAAMLDVGINEMDVAFICKLMIGLRTKIDVSIPLSSQPQLAQQFFRNIGVVLCLLERMALPSDIDGIREVLLLVDSQGMLIFVDDCTVFARSGMQTEIRGVHKVVSSSLFENRWEIEGYENRVACLLERLGCIELTEKGTLSKLITTNVRKILNSRDCLSCDDILKQGRDVLHFLALNCDKLASLGPKDIEVIRSMPVVVNTGKIARLGDPLIRFCPDHISACKLMTEDNELVKHYDNIRTFAAYKDLHHMFLSDEYLEGIAKYSKPSHDGFTFKDFVDTLAHIGVFSFITYAPLHLSVDACGKYELPVFPDDIGIAVQHRITKLDSDLRQSRQFGVHRTVKDWYSPDFARVVAVVRQLHGSDPCESRGGEQTSEDKGNDVELQLRRQCAHQLSTLMYHIMIKELEIHPDYCLATLQCGDRQQPLGRSLLYYQLRHIPWLPYEECVYKSGEQLRSDGVWQVALPIALENDIGYSCTLFKRLDAQVKNELLLPKKSYDLLEILDFLCAKCGKADIESRHSTETQTDTSQWLQHWTDAPTLHRLNHSFSKEYFDSILFNEPGVLRRIIASIYNGLYRAMQEDCLFALRVRTTFHCRNLVVVFASYFKSPGSPKKPMLCTSKDPKLAIYKSIIGCEGLAVLTEDYAEFPELTGFWKALGIKQIISVEETLRILDGVTNENVCEHLETVFECIIHLYNVMDKVTFIRTIWKRECIPVTCVYADMFLCGQEGSTRSSRMDRLVAPASGIILARSWDSGSIIQKFPLDPKLGIWVASRPVVGLLYSNTSQYLKRYSTDGNLNVDDMWERVLKTLGASEFKDYCQLQCVAGSTVAQCPWPMNSYLLVALLPYVNHYLKHRMIDQYDLCCQRILYLLHRIAIVITTSEVMMVYQYRKGDVLAKSARLSGESFVHCEGIGTMKIYAVVDTMPEHFAYTADVISSAQNAAKNGKLKSLPASFFVNLAKVLLVDPAASPKDINRRFMETNEHERMLGEFMCTVYEMIRSQPKDAVDVFVKGNSNGPSGKCLCADYVAAYPRKPLGSSTTIAAGCNVTGKDTSVKKDSKADADITIKKCEAPKQLTDKVTSDPAAAKKLPLMDGYGSHLDSGDTCLKKVMDPFIYHWLYAPPVGDQFLKKAASNSGLSPAGVNARSATTAKACLPDTKNKEASKSLVPFKCDVAGSAAQTSVPVDVVNKSAQPPSAVMEVTQPVDAADDSTILLRSEVCAPHVEAADAKGDGGNVERSFTPAAKHTNVILTAANDSMHSPLHVEQNIVSVPRKDPTDHGTTVQLYHGRSTSCKEVNKHLAYMLVLSDELRSAVGSVSLYEHIPSSKYVKPTKMNRQLADRMLSKTPVDVQRITAVGYLGEEYVFDLLQVLLKSELDSKKVAISWYNKKAESGLAYDLTIRNTEGEEIFIEVKSSSCANRNYFPVTYNEWCFAQQKGARYEIFRVSGVGLDDVNVYRIVNPYSMWRSGKLKFCLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6N0</accession>
    <name>A0A061D6N0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0301180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768399.1">
        <property type="nucleotide sequence ID" value="XM_012912945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6N0"/>
    <dbReference type="GeneID" id="24564754"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301180"/>
    <dbReference type="OMA" id="GDPQKKY"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="10">
        <location>
            <begin position="92"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="164" mass="18675" checksum="359AA3958C5C2259" modified="2014-09-03" version="1">MSRVTQICCRAELESVEYCNTELQVTAPVLRTNLDDTKRIIESYNRKQKHLINLYNRRREDVNHMLRETRCNYWASNLQCLNTLLGFTLCSEGDTLVVTFTHLGASNPTKLAFVTLSANKGIFEGISCVPMIRQFNALTSQVNEGVAFGLFVCNIRKEFKASFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6W0</accession>
    <name>A0A061D6W0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766855.1">
        <property type="nucleotide sequence ID" value="XM_012911401.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D6W0"/>
    <dbReference type="GeneID" id="24563210"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109670"/>
    <dbReference type="OMA" id="DSINVMF"/>
    <dbReference type="OrthoDB" id="329794at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595508" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1582" mass="171451" checksum="0D9437FE115DE99E" modified="2014-09-03" version="1">MELYWLLVSVISLWSVQAAPVLHNPFQVDAPLPLINLLQIGGIGSDAVTDVSPSATENTASGSFAGEGATNGQGAPAEAHASSDAPAEGNGVPAASADVTQPGNSMDTAGLATNSNYGNVTDAASSLVEGEAAAPGLPNVGGLDHEASQPPTMAAAEAGQANSMPADPTTTENVAASSSPVLSQGTDLSSGNIPSIDSDADDSILSDSSATTAQSPAENVNGGVASGDGSVEETIAPSVAPLTYAGQGSTEGTDATDSPSGSATDSTGQPETSTEASPASDTPTSDNAQPAEGTADATQAGEAGTTEPGATESETPATDNGESADASAALSTEAPPSTLIGEETPTEQAPEIPSDSYNKEDMEKNSDATKIDLGDVIEGGNQNLSNMTEKVDQEWLNKESTAESIQEKLPEGTGYTYNKSARMLTPVVQEPKMMGGVLQTLIDKEAEIRRRTEQAVHIEHDLRLRVTRETAEVVALLTNEDLFELKRSHPLVFMRIVEPLKVAVAMGQLNKSAHTIVSTYDRSWYVRATPKEKADLLANIRRDTGRAYLFASKVKKPKQMTPEKSSVYQKLDEFFNDYQCQKIIRGNQVAKQMLRMFSESSGLYVAPFYTDVVPTLGSLWMIARFEKFYSQSEMLRAEVLAKSLPQMVGRFMVMVENGTLLPTSINLQANLYSLATMLSKIMDGVAGSSKFMGKRKFYGFMGMCDASCARGIETDAIDGDASKKFVLNKQREILRWVSFYLRDDLLRIDTTVQKTMLELMFRTTNSEEFILSPKNVKLHLKSEIVKNNGPSMLELPRRRSKQPKEPKAPKQKAQAKDDDKERKVLMGRFMSGYRLPGRRVNNNADFRDIAPYNSFKTPAKLVASLDNGLLNMLEVISDVVNLTTAGDSSNLYFQAFNTWVQLQSFHAAIHAFEPNTSRRKTTSKTLGAVFRFLNMSASAHIESMPRQFLPFTSLILQLSFYFQNSVDGYERGKLKGLKTFFKGLMKFGLRSRLGPSNFDELHSYFETQVVYNKARYSIGRAVVAKLTSDFKMMFLGKPAVPTPIIQLITVYVGLWTRGSAAALDFADYTIDPVRKAFFLGYLSNKSDLSTYATEIIVQHCASKAPVLHLGCLKASDKGRRSCKQVSFRTNKSDVLKLMQTLDATLENPLDTVRIASDTARRCNAMPARTGIRSSGKKATSRDVTMLFSELAMRYQCYKAQVTAAGQLVKILSNLKDQSAVQSTIDNFFSSMRTITIKHSTVSENGPTLVCPFMDDAPEELRNRHRSRIVEYVMNRVKARRGALGIFKKIGSIFSGDKSSGVKGTVTSRGPLDNIAGCIFVGTRSYDGILFHGGFAPPEKIPIPESVAVRPGEGRVVYNGENFVSEIEALGPSTGVKAVTLEQRNGETRRKYVMESGDKFGEISFATKFKDFVVRAHVLTTASALRGMGYDIGKFIWCGYEHGWVADFALNNVIGNSDIPVFNGDYWVLSKQMVVADVVGQKVPIKNGEQIKDASVQNVNVEVKSGDGNSIARYPSNQGSPSSFITSGDETTFTFDTGYGNVSPAAVRDLVRNAEFDSATNTLVINLDAPVTVLQESPISSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D793</accession>
    <name>A0A061D793_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">STEP II SPLICING FACTOR SLU7 domain and N-terminal domain of CBF1 interacting co-repressor CIR containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0110710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766960.1">
        <property type="nucleotide sequence ID" value="XM_012911506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D793"/>
    <dbReference type="STRING" id="5866.A0A061D793"/>
    <dbReference type="GeneID" id="24563315"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110710"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="259" mass="29045" checksum="529175C40D1C13B7" modified="2014-09-03" version="1">MWMGKIGNKSASFINHKHFHPGNRSNLEKVWLAEEKHKAELKRQKEMREKLAEEIRMTQLKRQLREQEDQRYKEYLLEQRPPSKYQVPAAGSKLDGSEAGLIITKPATEAQPRSRDAASHKLVIRSSYREDVHECGHSSVYGSFYDRATGQWGYRCCGSLKRGAACPLKRRAGSRKGAASDPKDAQQGHTPATDDGNDNSGHEAAAEDDRKSHSGKRELEDDTGSPAERCPAKAAKHKRRGDLSLAEALDKLKKMEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7D1</accession>
    <name>A0A061D7D1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c oxidase assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0303570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768639.1">
        <property type="nucleotide sequence ID" value="XM_012913185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7D1"/>
    <dbReference type="STRING" id="5866.A0A061D7D1"/>
    <dbReference type="GeneID" id="24564994"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303570"/>
    <dbReference type="OMA" id="AFVCYSW"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="446" mass="49206" checksum="38FEDCF7D5539CDF" modified="2014-09-03" version="1">MMLNIARLGGVRLDVVRSFLHGRQRVPLCRQALQLRAGHSTNGAFRHYKEAVNIGRTDVSGASDSSGIKGSSEALFSREGEATPGHSGNHRSDCSRWFRIARPGKEKTVAYWLLGSAGITAGVMAIGAYVRLNESGLSMLDWHLLGKHLPKDEDEWDREFERYKATPEYKQVHYDISLEDYQNIYLNEWVHRMLGRFAGMCFGGGALFLAIRGALAPGGHLLAMGISGIGLSQAFVGKWMVESGFKEPETENKTPRVSPYRLAIHFTNALAIYSLCLWNGLRTLRAGNELASPDTTALRRVRRMGKATLASLFLTMLYGSIVAGNDAGLAYNTWPKMLDSYIPDDYAQVNCINHLFEKTGVVQFNHRCLGYITAVMSMATYMAARAQGVPTAVRKLAMGTLHASLLQVVLGIMTVVKHVPLHGAMTHHANALALWSVLIMMLAKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7E6</accession>
    <name>A0A061D7E6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 4 regulatory subunit 3-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0303720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768654.1">
        <property type="nucleotide sequence ID" value="XM_012913200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7E6"/>
    <dbReference type="STRING" id="5866.A0A061D7E6"/>
    <dbReference type="GeneID" id="24565009"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303720"/>
    <dbReference type="OMA" id="HFFYKHC"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="61"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="212"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="494"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="887" mass="99844" checksum="01FB0B60933BCA0C" modified="2014-09-03" version="1">MAVEPGQDELEAIEVELRSEPRLQKAHPVNGIPASCRRVKLYEIYSSNVGSAGYGNIDTQDTWVDKGTGYCHIKEPTDQGSPQIVIELEQEGMTVVVISNILYNTNYSSQNDSIIIWQEGGEGRLYRALSFQNVVGHKSFWTYISGLVDEQCIQSSDRDGGSGSETELDGDGDGGSGSGSGQNGSSSPNESSKFNVMYRVLPVPTVGELRKLETTLDAMLSQNSVSDMVYMDLLDKRWLMETFAIMRNCVEIEDLSTLSAIAAIMSRLILNWCGNLELMHVFVSDEMFIDLLQAFEYDAELLSQNISLEHVKFFRQHVKHHDVIMLGNPAFYRLVHSSYRIEYLKDVVLPRQLDEFSIQRLNTVLFSNTNEILNILSSDGRGFVESLKEQLPHKYMAALLLRELLGAARCSQGVNQPDRISLLLLVKHSQLLIELIGYLDGTAPACRDFREHLLPKNESMDREYTALKGALARMQDYRPDLLGTRRHGLMDPVSLAVEIFNLCLEVFPSIVRTAVFADAEAKSEPSLLFALCDVIATNPDGGVQAQTRDIFLRLLDPKNMDLPEKDEMCSLFYDNGVLDRLIERVFGDNVPDSPTIRVAKVHAMELLSLCAREHRHRFKLRVQSHKLPLRVLASSLRPFDKFVTVGAMKFLHVCIKMKDMSVERHIIKYDVLRPVFWILKTKISAGRDGGSMLESVCLGILSTIDTWALDGLVEWIFQDPVCSTLFEDLKRAYSHCCENFVFNNLERMYNYSRSGGMSNKKRHVIVDPDRWFEEDDEEEVEPIKRHIINISGSLVDGYDDDDYTGDIDLADITATAPGASSPLLRPADMEPWGHDSTERAKDEAEDVFEFSFKGNKATKINVFLDTCRKQPSAGGKIANDFVLDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7F6</accession>
    <name>A0A061D7F6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768664.1">
        <property type="nucleotide sequence ID" value="XM_012913210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7F6"/>
    <dbReference type="GeneID" id="24565019"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303820"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="95" mass="11164" checksum="1C4205F0BEB49FE7" modified="2014-09-03" version="1">MNIVNKYLGPYTLYNTAYSIYTVRRHTFCDLDGTYRHHSSFLIYLALNLQNHEPRTSAKDTAFSHRLHHQQGYLHPAHLQSHHNYAAITTEVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7I3</accession>
    <name>A0A061D7I3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768689.1">
        <property type="nucleotide sequence ID" value="XM_012913235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7I3"/>
    <dbReference type="GeneID" id="24565044"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304070"/>
    <dbReference type="OrthoDB" id="8015698at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="306"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="948" mass="110094" checksum="A61B312C08F9DCDE" modified="2014-09-03" version="1">MARQVVAKAARSQPTDVGEIASLHDVDSYNALQEDFDRIMAQRLREPGVIRTVKNKRHTMDSLDFSAIRSLDLVVHNYVKHNPVTDMGMLAILYQTAQDCYDKYSAKPSSSSGKKEAAERRIKELEEIGALLLKYKQKVPLEKEDRKRVYRQMDKYNMIADKPQELSYVISRTQEELQKEQDKLKNAKFKQELYNHNRMFELYTGHFYRTLEKQQDADESAINEGMMIEYWAQMWVKPNAPHNGEGYLVERPPAENMAGFPTYEEFVTIVKKLRDWKSPGADGIYNYYIKWLTSLHRVIYRLVEEACTQGKVQDDWFYCGITYLLPKNKKPKSAAQYRPITCMSNLYKLTTRCATETLKREVDGRGLRSENQMGTRSNVQGAKEHALANIALNEKHKGKLLATWVDVMKAYDSIHHAYLARVIDSLNLPGWLSNFIKQTTKRWNIEIRWNKNTIMHKKVERGILQGDSLSPLLFVLCLDPLSRHLTRIFPKVELSVPGGRIFATNHFLYIDDLKFFAHEESTMRGMGREVEKFFNDIGLRINRDKSATNTEACVSIAKQMEGPETYKYLGVTETSNSLTSDGMFDIILQEICRRTELLAASKLSGKNLSMAINQYALSVINYYIGVIPMDITHFDKIDLAVRRIINAKHGHKKWANTQRLYLPRKEMGRGLHSMVFRAEAMLLRLWLTFSADEVTSTRRAAIMQHFRDTYAHISHIKMHLEGRYGMEFGVEDTTDKSLRDLRVAQNKWLYNRMHVKSTHKVLYAKREDPKLDIEASSLYLTCGILTPEEAAKESAMDDFVQEMLKMQQRQELHSLLGRQIGPPKDKIDAHKIESEVHGKYGWIAYDKTVKTQKTKEYNRPDIILADRRRNTITIVEIGITNQDNLVDTEKFKKQKYEDLIEDLKARQFNQQTKIRVIPYVMTWEGIVTKEHSKYRRDLGISDRMEAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T8</accession>
    <name>A0A061D7T8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768794.1">
        <property type="nucleotide sequence ID" value="XM_012913340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7T8"/>
    <dbReference type="STRING" id="5866.A0A061D7T8"/>
    <dbReference type="GeneID" id="24565149"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305110"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28670" checksum="1A924E6A51202FB0" modified="2014-09-03" version="1">MGYPVFQPCSSLLCQPIFGITVFMGSLPSSPSQSLISKHNSSHDYAHPRTLSTLVGCGSDPDNCPPHCSPITYRPYALYSHTFAHTYLSWTVYLPDRLWESLQKLHYDLQKHHDSSKCYSLHQCSTALPLLYLHGFTPPEGQSQSPLTCKQVITMLQETVNGKPIASLMTAMDDFLYRVREPFIYTIVALWSAALLVIANTMLYRLDVLRIRSDLIRTKASYHIDVKALLTKGRNMLSLYKDVDYFDEDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z8</accession>
    <name>A0A061D7Z8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768313.1">
        <property type="nucleotide sequence ID" value="XM_012912859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z8"/>
    <dbReference type="GeneID" id="24564668"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300320"/>
    <dbReference type="OMA" id="YLCFPVR"/>
    <dbReference type="OrthoDB" id="365860at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="141"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="521" mass="58208" checksum="A185769AE6CF207E" modified="2014-09-03" version="1">MVTIKGDHFRFDTIAIQREGVTPPKYDTFRVPVPLETELVMPEEGTFRNTRESSMGKAEPQQYDTEKVSVVHSMTMDQVAVTVRPAFNDFIRSHIRELEKRMDVRMSLTPRDDVHCLIASGSKSSEAIVEMLNMCRTSRIYNYYLCLPVRGADFQRVFSEFKQEVIGLLGHEVAFEKRPHVTLALLNLVTDEDVDAVVRALQATTLAVSSLSTGADGKRKPYTIELAGVKPIVYKGRAAQRSVFMTHALPEDNLSDIASEFQDSVKRAVNNIIAASKKRVAQKKASKTKNTYNPGRWTEAEAAARGIYVTKGGNIEVTYADVALVDPNGAITDQELNDMLAELRSKYIDHDEPANKRKGKASVQIKQIQGVDPASRRQGNAQNVVPRDTKENDEDNADTTQPANVGVVDQDFPEYETSVTHEFHVTLLRNSKVERLQRLGFKTRGDVCCVELRPRGDETCNFKAYTKTRLVQFVGNRYDGQQSEVDDASYISGSAQPELPSDLVTDPGASDGSTERFVFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D829</accession>
    <name>A0A061D829_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768338.1">
        <property type="nucleotide sequence ID" value="XM_012912884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D829"/>
    <dbReference type="GeneID" id="24564693"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300570"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="132" mass="14599" checksum="177AE2229EB32CB5" modified="2014-09-03" version="1">MVARAIRPVWARVALTECYYSLGVMSLSTCSNIRLRILVKCALPWSYSTESSCLLILDMPVCQVCLAGDPGIEAMLLLFRRSWMSILSSLGGLVPSVFAYDLHRYHGNPPHLTTLNSYNCLSSALVFGHTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D845</accession>
    <name>A0A061D845_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small GTP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769022.1">
        <property type="nucleotide sequence ID" value="XM_012913568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D845"/>
    <dbReference type="STRING" id="5866.A0A061D845"/>
    <dbReference type="GeneID" id="24565377"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307400"/>
    <dbReference type="OMA" id="FWVNQIR"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="26776" checksum="CD39C0072E6D40C0" modified="2014-09-03" version="1">MSSKKSYKTVLLGDASVGKSSFAVRLTRGEFSDSTNSTIGAAFFTHTVRCSVPAAAGAADSAAAPRDRASQPGRDQASGRGVPGASSYSPDDAPAGQVSVKFDIWDTAGQERFKSIAPIYYRGAACAIVILDVSSSQSLQHAASWVNQLRVANSNETIVVLVANKVDLLGANEEHARTLENARSYAQEQALLFVETSAKTGQNISAVFEMLAQEILRNPKRFEHPSASKASRALNVNESSSRMIKLNCCDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D863</accession>
    <name>A0A061D863_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768909.1">
        <property type="nucleotide sequence ID" value="XM_012913455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D863"/>
    <dbReference type="GeneID" id="24565264"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306270"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="64" mass="7027" checksum="054E1FBD4DE58896" modified="2014-09-03" version="1">MTMTDHEKKILAPLCAILSLLVLAALTILVCKILNSNGIETIFDKMFRSKSTISYPANTTNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K4</accession>
    <name>A0A061D8K4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769227.1">
        <property type="nucleotide sequence ID" value="XM_012913773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8K4"/>
    <dbReference type="GeneID" id="24565582"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309440"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="129" mass="14672" checksum="A6BF0D6137A378CE" modified="2014-09-03" version="1">MTNGKFYQEPVNSTPEKNCECNGDPPVATYCSNCEDCKYLDCVCSCCVRRKVKIVGGVVVGIGLPIIIYCLATHPLPDFRKWHDYFSNLLGTRKLRFIPRSELDAPKITHITEEMDINPYSFFPSKDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8R5</accession>
    <name>A0A061D8R5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769292.1">
        <property type="nucleotide sequence ID" value="XM_012913838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8R5"/>
    <dbReference type="GeneID" id="24565647"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310090"/>
    <dbReference type="OMA" id="CVANHER"/>
    <dbReference type="OrthoDB" id="373479at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="143" mass="16818" checksum="267B03A60F1744DE" modified="2014-09-03" version="1">MSVLRYAVRGRVQYYPVHIASELQYKRMRMGQWPPEGASPLHPVDRALGQAVLRLQPETLLCVANHERKPLIAFDSIKEALEKYENEEQVSLNAMLRKGVQEPDMRYEMRRLEVLEDNYAMQRMKTGRHSSHTIMRARPRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8V7</accession>
    <name>A0A061D8V7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0204620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767490.1">
        <property type="nucleotide sequence ID" value="XM_012912036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8V7"/>
    <dbReference type="GeneID" id="24563845"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204620"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="97" mass="10581" checksum="52CAF009458D6C10" modified="2014-09-03" version="1">MAGSRGKTTAVVLVLYAAVWVYVFRQPRTLPVLAFLLSPAVLVATLGVYAACSIIRGVITFNRSYTATAELKEDLKTAVLGLDRLGFNFDKFGIPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D943</accession>
    <name>A0A061D943_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0205770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767605.1">
        <property type="nucleotide sequence ID" value="XM_012912151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D943"/>
    <dbReference type="STRING" id="5866.A0A061D943"/>
    <dbReference type="GeneID" id="24563960"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205770"/>
    <dbReference type="OMA" id="YNCKRDL"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="4">
        <location>
            <begin position="294"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="4">
        <location>
            <begin position="481"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="616" mass="69722" checksum="50EFC5BD9E534F29" modified="2014-09-03" version="1">MLKQGVDDTQDFFTLKDICFDCWRALVFHNEGFQNLEDILEHPKLHQRFEQLCTFDRSDGATCRFCSASTLPAAVTVKDDVLFEPNEALRTINFDGWNLENLFSNTAVAAETCAAPNKIVSRECTVSRGFNLCVLAVHFARTFGRDKRYPATFAKNCIRLNLTENAVAHFNSMWRSRIAIASNFVRETSAITSDADDLTLLIRAYFDNADNAVKPNLEIYEKRLKAVIIGILENEFDTFVSDYQPLFRYIDRIYHEDKLLFEQLLRIQIHVSFDVHDRLKITQFDMSRDVVTFAGFYNKFARGLSQTVWTLDRSVKSDLSVEECLCLPLLTLCNADAYKFMASGREDCDVRTTGTGRKFCVEVYNCKRDLFLVYELIHKLGRKTAMSHDHNHEESCQHIACLGELEKVKDGLQVSVTGGPRDHYFLLAGKQSDDQEATHRITIAGVPKMSLTEAFDGGSYDGAAVPSAACFYGIRVVFNSKTERQIVQRDAENKNKMYSCVVIAEEPITLEDLKALPQGPITISQCNPIRTSHRKSQCKRERQIHRISAEPIHPRMFLLHLTTQAGKSGVLNHLNNAGTYIKEFVSGDFGRTTPSIKAMLGGKTVYVAHLDVVDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D957</accession>
    <name>A0A061D957_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial processing peptidase alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0311290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769412.1">
        <property type="nucleotide sequence ID" value="XM_012913958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D957"/>
    <dbReference type="STRING" id="5866.A0A061D957"/>
    <dbReference type="GeneID" id="24565767"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311290"/>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="105"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="257"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="520" mass="58143" checksum="81EB741545927992" modified="2014-09-03" version="1">MILTRDLIFLQTTAASGAAEISRILTKAPAAYVNVPFVEEDVEQIMEEVPDFKFYYVGRSDGGDNPYRKVPLTDRIYIEGSEGRFEPVDDSVKLAKLPNGLRIASVDRGGMDSLVGLYVGAGARYERPEEIGVSSMIENMAFHSTAHLSHLRTIKTVETLGGNASCNAFREHIAYHGECMRKDVPIMVNLLIGNVLFPRFLHWEMKANKSRLDDRRKQIHETPDMIVTELLHSVAWHNNTLGLPNFCPEASMANYKPEVLRNFMLRHFSPDNCVVVGINTDMAELSKWVMRAYNEYNAIEPVKREVERPVYTGGVRYHEDNTPLLHLAVGFEIPGGWNKPELVVFTVLQALLGGGGAFSTGGPGKGMHSRLFLNVLNKNEFVETCMAFSTVYSDAGICGLYMVAAPHASRNALEVMANEFRAMATVTPKELERAKNTLKSYLHMSLEHKAVQMEDIARQLLLCDRVLTVNELERAIDSVTAGDIKSCVDRMLKSGKPSAVAMGNLTYMPHPEEMLKYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D963</accession>
    <name>A0A061D963_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767630.1">
        <property type="nucleotide sequence ID" value="XM_012912176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D963"/>
    <dbReference type="GeneID" id="24563985"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206020"/>
    <dbReference type="OMA" id="THVISKY"/>
    <dbReference type="OrthoDB" id="361833at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600711" description="Derlin" evidence="1">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27822" checksum="97D489CD49DF9629" modified="2014-09-03" version="1">MLAISVFLHSRWILRALFLCLAVNNVNVYCAKVSDLTPRVGHNNAIIPRFHHLERPSSSLRDLKRSVKHVLDRCAETPVSSSLGATSLLISSSVWIGLVRPESLMNYGSRRPFLNCCIPLASAFLIPELNGSGVLNLLSFYVLLRQSEDANGSAHLLRRLIYNLLTTTVVSGVFGMPPDFHKFSRAFTVANALENPNHHVQFQGVISMKQWHLPLALLLADYLMTLRMDQAIEGSKATIAGAATYILCNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D989</accession>
    <name>A0A061D989_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766466.1">
        <property type="nucleotide sequence ID" value="XM_012911012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D989"/>
    <dbReference type="GeneID" id="24562821"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105890"/>
    <dbReference type="OMA" id="THENACG"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1001" mass="109811" checksum="0872A2EB00073437" modified="2014-09-03" version="1">MKTRKGKKGTKQATPTKRARNVGSDDDPVECEQESVPPQEEAKSLFFPATAVKEDGSIKEGEHGIEIVGAAAESGVSKTGEDKLLSHWLFADEGTAAIPPKRGPLGTVRAATPQNFKLGSFNQPKSDNAAERTDEVTNDVRSVPPSLSVPTTVTENKVSSGFTMASGKPCPTVKPEDIARIKSLLGLDASDPSATESSGPIQNASEKTQPADIASTNIAPLNPMTAIGSRTKIKRPKTTSMEQTQRPSPAPVGATQTDKLKEEVNPKANKPSTTDTFTVSSSIKRDAPCINTDCKSLLPPRTKSVSLLDMWCRNCVLTNHDGSSVSPAMLSRLWNIYGNPLTVTYSNSEKFTFIMYSPCDASITVGGFNEIQKCFKQMMEQCVEPSMERMRFDEEWLRGKYCLFTTAQCRKFRKSICKRMRKSGNLKDTLRKVQLPNVLTVLAQIIKSFNKEYGGNESILMRILHGDAPTNSPVVIRVEDVHGDKVYITDGESVIAANAADCYVRQLLKTQRILPGNKLQLHGISIGTDTSRSEGCAAVQINLNAISPASKKPLGLQNRHSNAHVRELKAGAGRVAQLDLTVLGVMPPVFKVFYKETGSNATKVATFSEWDFNSLFADPVYKPPVTIESVYVHHTLAVIDTIILLRIKDYQQDPQRFEKALVKSCALLTLRNIDETIMGMIKPTTRLIVSSLTVKNSGESRRYNTLTESSAHIGNYLCFETSTQSRLDIKERDTPLQQIRKTVAEFQKGIKNGAANGADSDAAKGGAKSIFHTLILGEPALSISVHSEQEFFDILQQGGNQSAYESGELFIDQVCSLTGLVIEAGEIVNMGRDTRAFRFFVLTTRFQLAVIKVSERAVLLPTHSGTHENACGKLERIRRRLLAQRITVARAPEKPTRKKEALLIACLHLQYAGYDEAHNVYNFNTTSSRLQTRLHNGLVFAEGTGFALSGNALRAAGDTQLDRHCRLFAKSIAQTKLKVCHLLHTSVEDVKVCEEMAAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9D8</accession>
    <name>A0A061D9D8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769349.1">
        <property type="nucleotide sequence ID" value="XM_012913895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9D8"/>
    <dbReference type="GeneID" id="24565704"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310660"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="162" mass="18784" checksum="2CBEF4C4C4E2CD80" modified="2014-09-03" version="1">MSYEGKLCPKCNNECRSLQVCNCCFWCCIECRDNDCTYCKNFYYERETGTLSDHCQPPECKKQCNKCKKPNCECPCCRLRRSKFAPSQSTYSDTTQYVTSEQTYSSARSFAHDSYSPNVLPIIIAVVALIISVCVMIGFRIRPFHRVRDFCARKMNGLRRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9F7</accession>
    <name>A0A061D9F7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767750.1">
        <property type="nucleotide sequence ID" value="XM_012912296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9F7"/>
    <dbReference type="GeneID" id="24564105"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207220"/>
    <dbReference type="OMA" id="CRAFASW"/>
    <dbReference type="OrthoDB" id="363299at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14246" checksum="CEBD5D7A1F055929" modified="2014-09-03" version="1">MTQAEGFDRASTVVLSGFQPEYTVDDCRAFASWFSPVIHVEQLPIVDGKVRFAVVFASTAHVEQLLKYKEISVENGVVEVTAPDESDTVWNSVGDMMTYATAVPIFQMAQDGLNVALNQLSLSWGGYLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I3</accession>
    <name>A0A061D9I3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769389.1">
        <property type="nucleotide sequence ID" value="XM_012913935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9I3"/>
    <dbReference type="GeneID" id="24565744"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311060"/>
    <dbReference type="OMA" id="INFKCKN"/>
    <dbReference type="OrthoDB" id="361235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="332" mass="39844" checksum="E20EFB0B3F5800DD" modified="2014-09-03" version="1">MTRKVVFGYRYNAERVKRKGEVRSKIYFDMYKDKHPLYVIHRFMHENDPDNPNFKYDVELATKPPCTRHIFKHYKKDNKLRFFWYASGKKMPNGPCSRYINYARSYNEFRFSKLTSFYHILPYVHEHYKDDPRYIYFMNRFLSFHGRVAEAKRELAAQAEREGLEKPNEYRRTISWKEMRAKRKQEEAELYEKYGIKDKIVVNMGDGKSFVVKPDGFKVHGEYYSRIDKAERDSPYDIYAPYYRTKHSSKRRRFRERGVPLDPAERCKTRRERLLKRKAEREARDGPNAHAKKFMKQKKSFKVPRPPGWLPEECADLADILTPAPDAGAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9R2</accession>
    <name>A0A061D9R2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S18, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0107680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766656.1">
        <property type="nucleotide sequence ID" value="XM_012911202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9R2"/>
    <dbReference type="GeneID" id="24563011"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107680"/>
    <dbReference type="OMA" id="FIWRHTH"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="364" mass="42833" checksum="BA8C4475CD91E012" modified="2014-09-03" version="1">MAPLCDIRPYAALIRRFCAASARPGSTQPSKNPPTSDMSFEEIFAKAKPTQQHKISEEGSYDALYQECMSDIYRRRAEADGYTDETRDSPEVLEFTRKEREITRAIFKRANPCQHVMMQQLMPKLDQRNEYIDPYWDPFKRLDGLKLQVAAEFNDLARLISAAEVRKQRKMIRDAAESFDKFGDPYANESEPKEASEPLASNLNDRFWDPDVDRRLVLQNNRRPFSFRGRAATKCINALTDLHVLHNFVAENGQILPRRLTFATRQQQRQIFKAIRVARQMALFPYEWKPRYRDRIPLMDPQQYLADELFHRYAYLGDLRAKAMLHVVMRKYPHVNCFRFLKHEAQRFTNGANFKETLDEHRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA64</accession>
    <name>A0A061DA64_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0313300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769614.1">
        <property type="nucleotide sequence ID" value="XM_012914160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA64"/>
    <dbReference type="STRING" id="5866.A0A061DA64"/>
    <dbReference type="GeneID" id="24565969"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313300"/>
    <dbReference type="OMA" id="YVQTSYE"/>
    <dbReference type="OrthoDB" id="372718at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="521"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="579" mass="63641" checksum="1172BFBCE1BFD177" modified="2014-09-03" version="1">MSHNSSGLNPYGSYGDMAPSLPLEKCAGAEGSLGTKEGESLSFEPYDETTTQRSTSLVDDSFGNVESYPSDANYYGDRTGCRSSFTDGFADVDTVDMAIETNLFADTEYPGDCLDHYVNTYGNGRCVGSTCGFRGFTPISEEGSVDAVHPSIRPLSTPEASSIMDDFSRYGLTPRFRQVDTPCQPFTRQGTFIEPNHHLENFVRATSQLCQSMESSFTRPSSECTRSDFSGFGIGGMRVTTPPAGSSLEQRGTSPADSSLPTQYFQSSDAQAYDSELFFTPTLSNKDTRMCNNYSVASNYCVYVGSDSNVQTCGCNMSRPCGGNCHVSGCPLVTSELEPSTEHWPVSGSSHLQSLVRRLDCVVESYKTVPRACADSTNFRRLKSRSVQHHNKGGFSSARESISSNSGEFVKRSSSIPAEFSERREESPSSEYYVQTSYEDSPYNNDMLGEVDPPAKHKKTSSIPAGDSAAEIEMPSRNEYGRFVPSRTTSVDSGTDGRPHHTTPKSSKKKSNPAANHTGEKVSGVWYDTNRHLWRVVYMKGNKRKTQGFSSIKLGYEEARRKAIAMRHEMVAMRRPDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA68</accession>
    <name>A0A061DA68_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769619.1">
        <property type="nucleotide sequence ID" value="XM_012914165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA68"/>
    <dbReference type="GeneID" id="24565974"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313350"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="200" mass="21726" checksum="D7BAE83BF870A054" modified="2014-09-03" version="1">MGLVSLYCMTRGCRMAAGRRGSVAWPCENRLAVTAVEGTGRGSGTCCSWLRGVGAAVVEGTGSGGKMVTGERYLDNQCNTNCNIATCSCCPWCCDKCNSRSKCSICSEINTPLRERKVCRPSGCGAGDYTCTSEACECNCCEQKRSTSRAQHRVSGQQSTTDSSPIPYIIVPVALIIVVICVMIYFRIRPFHRVRYLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAJ4</accession>
    <name>A0A061DAJ4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxysterol-binding family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0309050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769188.1">
        <property type="nucleotide sequence ID" value="XM_012913734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAJ4"/>
    <dbReference type="STRING" id="5866.A0A061DAJ4"/>
    <dbReference type="GeneID" id="24565543"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309050"/>
    <dbReference type="OMA" id="DIKISMW"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13293">
        <property type="entry name" value="PH_CpORP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="825" mass="93886" checksum="AC2D929963798DDD" modified="2014-09-03" version="1">MASRNKKRYLHEGWISKWTNFIGSWRPRYFMLEPGCLKYSLEKDGLVKESFILSQCTMRLCADDPVRLDIDVVGRGVVCLRTDTPAEKQKWFVAFKKAQKILFQAYQKKVLTPSGVYSIEGRPGAYGNSDTAAEQEGTAVLESPQHYISVEAPAAVPGKASDEPSVVSPEGDDLAQDSGRKSVDVSELFIKTRFGQEPQTSLNCMLSNTSCFDEITTKILAELREVLSGDSLKKVETLGLIAREYYESTQQLYLEEVRSRKELEQSLFRVTRRNMKLEQQELTRSAGVVERKGHLAEMHVSEKSHTVDSEDSDSSDSAYCGHVEDEFFECEDFAQRTHSESFEDELVATNDVVPAEEPRQESPKGAMSEDNATVDAASAPAPASGKVPRGAVINRRTRLPRPRTELKVSIWSILKDLIGKDLARISMPICLNEPTSALQRDCEAFEYSHLLDTAAQQANVIDRMAYVTLFSITPYGSAVGRAYKPFNPLLGETYELTHRGFNFVAEQVGHHPPICAFHCHNQYFEAYGSTNALVRLTGKSVEVSIIGPFLVNLMVGGAKEQYSLQRCYVVIHNIIIGKIWIETVGTAILRNITSGEFAVVQYLRKGWFDKDFHKVRALVFDRYATPHYHIYGKWSEVVYMESVRPRSVRRQKPLLKPDGRLDYDTSFYKNEEDAWDAFVNEIDWEKIDVVPGTKKQVWKPHPRPPCHENYYGFGYMTMELNELSPDYDPNRGVAIPPTDSRFRPDMRAYEAGDMDWAVQEKQRLEDRQREAAKKRIDGERSYKPQWFNKKLDPHTRAASWEFTGEYWFRKAEGTVAEGVPDIFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAJ6</accession>
    <name>A0A061DAJ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768105.1">
        <property type="nucleotide sequence ID" value="XM_012912651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAJ6"/>
    <dbReference type="GeneID" id="24564460"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210690"/>
    <dbReference type="OMA" id="DVAEINW"/>
    <dbReference type="OrthoDB" id="366202at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="174" mass="19177" checksum="750DD669346ABCB8" modified="2014-09-03" version="1">MRLTGSAVSRRSSACPTRSSSEQYIQRVGGNGPVVAYVCKGVCKALWAACSPRAGLPFADLLAEEESKTICKNVALPQSAVQIREARDSQCIGRLITLSEADVAEINWLLGGRVNWHFIKLKGYAIAIILLIALLAAGMVYTKRGYADRRRRAIERKIAEKESESFLELNVNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAT1</accession>
    <name>A0A061DAT1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769288.1">
        <property type="nucleotide sequence ID" value="XM_012913834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAT1"/>
    <dbReference type="GeneID" id="24565643"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310050"/>
    <dbReference type="OMA" id="HENVHSY"/>
    <dbReference type="OrthoDB" id="364180at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="27525" checksum="F7406B98BB8208EF" modified="2014-09-03" version="1">MTHIIGANDTDNYRVCLPLDLNGDTCPLDVTKDLQKDGHWYRVVNQFTHVLGDVTFGNRVVKGDCRYTVRNVYEDTNETGRKVVKVRTLHTDNTIELEEYVETEPGSTTYVELKRIPIDLDMNAVEFPNHVYPLYNPSTRSTDIDIHPTYRNTYRIGKVTIAQQVVPDTPCIGRSVTLWGRRDGRRIADVATVHFDEVITNDTFIEQSAGHANFVPYDPNNGTEDIRIGLIEDDLDFDMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAU3</accession>
    <name>A0A061DAU3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769864.1">
        <property type="nucleotide sequence ID" value="XM_012914410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAU3"/>
    <dbReference type="STRING" id="5866.A0A061DAU3"/>
    <dbReference type="GeneID" id="24566219"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401700"/>
    <dbReference type="OMA" id="YLHCIGT"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF23">
        <property type="entry name" value="SPHINGOMYELINASE C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="320" mass="36384" checksum="D03FCBB9BA868835" modified="2014-09-03" version="1">MAQLVPVTLMSYNVQGIPSFLLPIADLDSRISAIAQYVSHVVRRYNVDVLVCQEMFSYTLYNEVKKALKDYMGLDSGILPNPFTKSGWKGFWDRVLRTVNIIGSGVIIFSKHPILNREKLLYSDGVYTDVYAAKGAVATRISVNNRLIDVVGTHLQTFREKMAHTVRVAQMAELREWMGTLFGRKGRLNPRRNGEEGVPIVLLGDLNCCIKNQHDKFWEVFSAFRGELETAFGFEGIQPTFSTRINDFCRYQQRPDEYDDVYDYIFKPPQVEVLQPQTVVRDSLKEPIYVGGSSISSCLSKPQPIHHASDHQPIFAILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAU7</accession>
    <name>A0A061DAU7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0111230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767011.1">
        <property type="nucleotide sequence ID" value="XM_012911557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAU7"/>
    <dbReference type="STRING" id="5866.A0A061DAU7"/>
    <dbReference type="GeneID" id="24563366"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111230"/>
    <dbReference type="OMA" id="NWTITHA"/>
    <dbReference type="OrthoDB" id="5600060at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="807" mass="91278" checksum="A5ADAD5ACB99E84B" modified="2014-09-03" version="1">MEVRVICDCTDCSSRLVEIGGVNVLCNLPTRLLKQCKTELGQSYYCHSKGYHNQELYAKLLCLNIHIIVVTTPRGLDGLDTLRKFYDLSSTHIVCTRPVYTIASLSAPKTIEEGPIAAIATDVKNVQHYNRNTKVATPRRNAATEDYQETPRSAAHLMDYDDDYYDEYIYPYDKYGYVGGRNRTWHTLESVGHMLPINAGRGESTRRVDHIMRRGVQETQPPHVNTQESRDVMAYSMRKALVKEKIQVLASASTKGMERQPPLDACFNTPNSYVRHRASSAYSMQEECFNWRGDRSEDLEDQPMIKDPNLPNTQLLHAVSYNEIVTIVIDGADVYKRSRRGERSRSMESLFDRSRFVFKATIELCAFSSGFSLGSSNWTITHAETFTRVALIGETGEIGYHRYCKPPDLSFVYKADMLVLLDNAVAARNVQQQFKVEPHLRREVKRQRDDVQNAQLDNLCKQALEGLQNAEGVVIVADPYGETIFDLLEHLELYMQRYLKHHERVLIYALGEGMVNILSYADKCAEWVEPRRADRTMHHETPKSPFTVLAEMRDGNRLFIGNTTEDIKDVYRYPSIVVATYDQVTIPYLAGRMHAGATMIATAVHYSDELLHLATEMGIQARIMNVTLDFRVMAEHLALMLGTKCQIITSKNMKARMSPSLRLIAGDNVRMPIAGPSGLLTTDTRAEYISRALARIRPIIGGTGAVPVHITVADGELQQATPINLPDDEPRFTFGTFTPTQLLEKLRMLGLNQCHIRNPTDGYPIEIIVDEECSIILESPYETSVNTASSEKRRLVTRALEQLCTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB65</accession>
    <name>A0A061DB65_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0201320</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767161.1">
        <property type="nucleotide sequence ID" value="XM_012911707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB65"/>
    <dbReference type="STRING" id="5866.A0A061DB65"/>
    <dbReference type="GeneID" id="24563516"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201320"/>
    <dbReference type="OMA" id="NVKWAHD"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="331"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR94975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54783" checksum="CC845DAA9383E468" modified="2014-09-03" version="1">MEGKRDAEASAGEHGNHDDVNSDHSTAHRGQDSIANSPKRARTNLSGHTAVRDKVASVEEPGTVTGEAVHPSAEGSADGADEVEQSEDHSTSEEPQQNACEDVENAADVADASQSSDDGNSADDVSDSQGVKAVNTYVGRIREKIEAGELDQSIVDSLQLQRLVDGCAVPLGQEDVEVVVAAPDEEQRSHLEVLMSRPARQQIKAFEGNAYIQGSEEYNIWYNKWSGERTNTVNGRATLMPAMYKCDPERDTGYTRGNSKNTLDDCGTKYCCLFFAKGCCTLGSKCNYLHRVPTVEDEFFLDSGVDIFGRERHAKHRDDMSGVGSFMTDCKSLFIGDVYPDNAEYNPVENLKQVLTEEFGRFGRIVELNIVPAKGIAFVTYESRVIAEFAKVAMASQPLGNYSTALNVKWAHDMKKENRKKGHERAAFEARVKQHESQLEVFQEYFLKNNFHTTGPSAAEQANAERAVRERERLDKLHSILRGAEGADEDRFEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB81</accession>
    <name>A0A061DB81_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0201520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767181.1">
        <property type="nucleotide sequence ID" value="XM_012911727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB81"/>
    <dbReference type="STRING" id="5866.A0A061DB81"/>
    <dbReference type="GeneID" id="24563536"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201520"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="223" mass="24922" checksum="F293D31B8C105F9B" modified="2014-09-03" version="1">MFGTTGKSKRRKFLNDGVFNAELNEFLSRVLAEDGYSGVELRITPVRTEIIIKATRAREVVGEKARRIRELTSLVQKRFNFSPDTVELYAERVEHKGLCAMAQAESLRYKLLKGLAVRRAAYGVLRHIMESGAKGCEVIVSGKLRAQRAKSMKFKDGYIISTGQPAQTFVSTATRSVQLRQGVLGIKVKIMHPHDPEGRLGPTTIMPDTITVKEPSPELEYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ0</accession>
    <name>A0A061DBJ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768455.1">
        <property type="nucleotide sequence ID" value="XM_012913001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBJ0"/>
    <dbReference type="STRING" id="5866.A0A061DBJ0"/>
    <dbReference type="GeneID" id="24564810"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301730"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="332" mass="36584" checksum="A43F2EEDA273E724" modified="2014-09-03" version="1">MVYYSLTEAPHNLKEGIDWLIALKGTDAESNIAALGAAVYDFLADKPVGFTKVPVLEEVKQITKEFMEQEQLKDLWPARELLWRFDNSANKHSSYLGRNFIVDESDHANIITAHGVETKDIAQDLTEVVDGCEKFLTQIKSTDLYVSAYNSEATWEASCSENPEDCAAVFVGIAPMLYAGLRSLRSANNTGALEYIGIKKETNLETILDAMGYEESDLQSDVDRSYILKALRSVNLRMLSTLFNLSGFWAFYGLYNKLPVAGLSVKTSGHGKARASVIAGEDKYEIPFVDVDMGSNSKFAKKPAKTDNALGSDNIYYSGVPTVADLGHAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ3</accession>
    <name>A0A061DBJ3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0202770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767306.1">
        <property type="nucleotide sequence ID" value="XM_012911852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBJ3"/>
    <dbReference type="STRING" id="5866.A0A061DBJ3"/>
    <dbReference type="GeneID" id="24563661"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202770"/>
    <dbReference type="OMA" id="DNISCTD"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000053">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="11605" checksum="6F603DECA80C33DE" modified="2014-09-03" version="1">MLFFNFFQTLVEKGANVTIELKNDLQLTGRLHAVDQYLNFKLSNVTANDTERYPHLLSVVNCFVRGSVVRYVFLNSSDVKTEELQELCRREAMKQSSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBS0</accession>
    <name>A0A061DBS0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0405030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770204.1">
        <property type="nucleotide sequence ID" value="XM_012914750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBS0"/>
    <dbReference type="GeneID" id="24566559"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405030"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600779" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="831"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR98018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="961" mass="108693" checksum="DAEA76140A4B3DC6" modified="2014-09-03" version="1">MGAYHVLRALLALCAIWMDFIPYIDAMICDFAGPDELLVHNALVICHMNMDDFDSASAICPHRVNETEYIWHPQSASDDHSHFNTYISEYGAFKSLALSNVFITDAPVKFVSMESHQSQTAIHFNVPIHDVFAVTDHRLIFVCGPKDLVLSAALQRRLDALDGYAETQKYPWSPATPLTEEIEKMGRTVGLGVLFLYREHLTVLLQGCGSRPSPLFDPDVEVTVDRATGTRSCVANPISRSPIGFLCEGKIEPEDCMRYLLDQNGEVVVAPEPYSYLKFYDTRWVVARYFNSLALPPFQGECRCIDSETGQVKARIEVRSKTEYICDITGKIFRNRVRPIRGHWCSVVLHPGSTLTIRFPIDSATTISGEDSDEHRQLGPPSQKRAKYLFETGFQPTDLKRMRQLKNHDGFNLYYDVSYRRIIAGDALELDVSKMSQGEVKLIYHMNEPLALRSGPNSFFYHWTLNAVSKYIFDRIRATVKVSFAFTHRYTILGCDREQRRVFNDKISRKYCSTKWMGNGVGNIYECLYQNTPQISIVGIYCSTGEELLPNNCESTAYDLNTNRIMPLPAYVRNMTPYPMQRFQVFDIAFHTTNAFSCACVCVDQRGYERSRLVLQSNDHKHYVYEILRKDAPHPILPYAVLPWREVGLWSDERSLLRSFVLYNVYTTSHILHVGKTLWLDCGVGSETPPHSAPNDVASNGRRAASWLPYYTQHFYYTVNHTASGPEIIRKTYGESIASTGGFRIVDNDPQIRSYQRMMIQSHMNAVLVSKDPVHKKFVPMTFVCGRNPDPSDLTVVSGDVSASTISHVTASSAQYASYLVQVAVEMTDPYMQGCGVTYLSTELFRPETPKLYDADGELQFGCQIDIETAKEAAFYCPAPYVLDPPNCFDQVYVNGEVKNLTEISKSLIASASSHFVTLLFDSARIGPGETLHQTPPLECRCVTIKGIVLSTIHIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU7</accession>
    <name>A0A061DBU7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">-Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0405320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770234.1">
        <property type="nucleotide sequence ID" value="XM_012914780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBU7"/>
    <dbReference type="GeneID" id="24566589"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405320"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR98048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="513" mass="55904" checksum="5FB97F7AF4D55CAF" modified="2014-09-03" version="1">MAEASPAQMTTPKTKIGTYGPLAEALYYLVSFIEGYDQQVLSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCIIWGLLADKYASKFVLGGGLLVMGMASIFLSSASHYKVILFLRFLHGFGFACVYPVQQKIVSDSTDSKEAEEAAKKGEGAQNQGKKAEGAQNQGKKSEGTPNQSKKEEVEDKKKESKAASTKFTIFQSLNCIGRLICAVITTIIARKVLLGYYGWRTSYVVLGYVWILFGVAIVFGMRLNKCGGGNSDTTQQKEDFLQRVSRAFQEVFTKPTAVISIFTLFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSGAGGKIIETIAKKEPKYGELSSGIAVMVVRLVVCLLFFLGPAPCGKLLWYHYVELATLGGTLVTVGGVDRAIMKDVIENDYQATASAIIRTISGISSSVILYQICAYLTEKVFGYVPSRESFETMATDIKERNAEALRKSMMYIILAGTILNVLCYVAMCFTYPKQREKMKNTGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ4</accession>
    <name>A0A061DBZ4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767461.1">
        <property type="nucleotide sequence ID" value="XM_012912007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBZ4"/>
    <dbReference type="STRING" id="5866.A0A061DBZ4"/>
    <dbReference type="GeneID" id="24563816"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204330"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="338" mass="37373" checksum="A103751FC8F0E263" modified="2014-09-03" version="1">MVYTSLTEAPHNLKEGIDWLMALKGTSDENNLMHMVGTIHHLFSDHSAGNNPLPSLDKIKSISKEFLEKPELRDNMLVRILLSRFYTPASAANTGSRHYWHRQFNEYGRVVGVKGAEPEYIKDCLSNVMDGFGKLLDDIKTPDQYESSYSSEATWEASCAKNPEACAVVLVGIAPMLYAGLISLWGTTESKTGEFHRYAGSRSFGEVLRALGYVQPQCRSDINGSEIFKNFKGLDDDLLHNTYDLAGFDVFYGSKTPVPEKAEPSAESTLRAKVRKFYMGSREVYGIPGVDVDMGLVNAWNSKTYHNKRPKISTASATGNFQSPGAPTVANMDAASPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ7</accession>
    <name>A0A061DBZ7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0405920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770294.1">
        <property type="nucleotide sequence ID" value="XM_012914840.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBZ7"/>
    <dbReference type="GeneID" id="24566649"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405920"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="14">
        <location>
            <begin position="1083"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR98108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1650" mass="188604" checksum="78D89AF418CDA457" modified="2014-09-03" version="1">MTQCLDIIRSQNVSKLLEWLVEDDSCRWIELMSTLREHVDKKDVATFCCEHVRFLATGRFSKVRQLFDDENLNAIATGLGNGSIHSTIDNPILPEQEQITVKRYTFEDFDDLLEAACDRVEPSLAFVAAIEYLRHCHSNIERILRLLEKTITRCTDRAPRITTAAAALSQVFQHYKDLSPCIGFLQRMWVLDMNDMHNVSKASLTSLVLQMHTSVICGKASFEDRDAGVHLANLLCCWKNDVLSWVSRICVYSSQTTLCTLDTTPLDEALCCFWLLTDDRSVMPQVYSLQCLVSMHIKVTYVLVSNDVDAQFNLCDMVSKLCARVDTMVEKSGYLLASPPDDIIMTLLRCCSLKPLSECALKTIQTFMQLLPDDGQVDLFCRVSSRCSTDASLATCLRTLGPHLLSITPRLQMSIIMALKSLLKRIIPDVCKFHESLDCILTWIESLHPLVEADSQGSKLSLDIHHALTQLIVDGDLSAEHNARLLTVIEPQRSCKRLLQYYGQVVKAHHHLVEICGDDVDFLSNVCGLGSVCDEKVEDEHYLLAVIVSRCILVQTEPTNVRNVVDVRKEVHNTLNCNLRSTTGEQCKRKGHCFMNLQRDSLITGVSLAHRIRNPGIFLRSAIFESISKFAGREVIHGILHNRRVLVPDYIFKFSRDVGCSLLLGENATPEELKIIRSFLRDVVIRMDSIYIRQDTGNLVSRPFVFIQLTGTVMYNDNFCVSMAKGTWSHITLSRNLMLYKDSFNGKFGFGRASLLEAVVELFTRHGRESNSTDLRSNEDAFQLNYSTKNNHIRTLFNPAKNNRPFIASNANDRFYVPLENNTIHSSVVWKLFHFVLFDKGFVHSQLKERYNRVRNFIGNLTTVHRETVKRHRGLMSSIYPHFKKLLYNIRCLDLRGEYWSYFGDQTISDSEKNSGIDHNRVISFVHKVVERVVPRSLLGCEENFARLKDVCRSIVVLNKGENLDMSQVMQGFKATGCPWYGDKSVRLSRSKVRTILEYICRLVFLILEHMVIPLLRRHFYVTEADFSMYRLLYFRKADWHRMVMLANEAYTSDPGSIPHERGHRRERMSAALEDMTRPVTVSDPDLSRYGALGGCIRVRWIPKLSGMRPIMNCNTANVTRFGKYTNCSVNSMMRMPFQALTAHIRMNPRFLGHGILGYTGVFRSIKQWWARFMRMMRHSTPRKNFVTLYVTLADLSRCYEHIKHGYLLRLLSSMKIQGNLLFKHIYRRNLIHVASFPNSYGKRVTYLSNDSSSLSPPQIWSLLSCSFGQFSIYSRYVNRDLSQHVSKSDIVAAVKMLLSRCSTSLPKCSPSQLFHKNVGIPQGCCISPLLCSLYLAQGDLHGSVRKLVGTNSANLLLRWIDDFIFISNGEEDTVEMLKILRDTSVFGMAINDKLFTMRLDLPVSRNSTKLTHHTSSSNVEVVDGFRKPFDNTVSRMSTRAESCTGLRDSVDTNGEALLSWINCSFDFDLVRGRLNATLIPWKNELCSIRDSLKLSKKPFTTPMFAYIEQRVLGYIANRLKHGLFTNVELNTQRCILQNSYVVMRIATMKAFSFASALLGEFRGFMNPKYIGKLTHKMVDYALELISLGGLDIRNTRLRDLLQLAVINTFSSTWHRRLRRRYSRRNIAFSRAIERLFKGKWPSYGHASPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC33</accession>
    <name>A0A061DC33_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0400640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769758.1">
        <property type="nucleotide sequence ID" value="XM_012914304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC33"/>
    <dbReference type="STRING" id="5866.A0A061DC33"/>
    <dbReference type="GeneID" id="24566113"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400640"/>
    <dbReference type="OMA" id="TAQRGNC"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000003">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="6">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="168"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="331" mass="36680" checksum="DC5D679AD2540913" modified="2014-09-03" version="1">MRCWLHINDFSKRLFSTAYGNCKRNIPIAIDFDAGRSRVAIQKPLLPTPLTQDANSRILKAVGSHQPLAKCRVVEQLSVRRVKFGGRNDTGRITTRHRGGGHVQRLRLIDFKRQRKDVPATVLRIEYDPTRSAHVALLQYVDGVLSYILCPAGVRPGTILVASASAPIEPGNCMPLRNIPVKSIVHNVELRPGAGGQIARAGGTYVTVVEKDDTFATIRMASTELRRFPLDCWATLGQVSNIEHAKRVLKKAGTRRNLGWRPSVRGIAMNPNAHPHGGGTSKSGTKRPRCSIWGICRSGFRTRSKEKPLGLIMKRKLCGRLMKKYGISKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC59</accession>
    <name>A0A061DC59_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768715.1">
        <property type="nucleotide sequence ID" value="XM_012913261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC59"/>
    <dbReference type="STRING" id="5866.A0A061DC59"/>
    <dbReference type="GeneID" id="24565070"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304330"/>
    <dbReference type="OMA" id="FGHKYLL"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="72472" checksum="8BE2A6E324091283" modified="2014-09-03" version="1">MFLILRDPHLTSMLRDVRGLLCCSYGSRISFRKYDRSARRRCHECHFCRVSASVLEVASLISRVIASGFRHLTVFLYLEEERYLHSTFVLDYIHSLYALVIQTCSSHGAQNGLGGSEDAVGVLNPNTHNLTVLPLHDWRLLVENAPLCSGSSSPSSARFLHVAGTKYLFEDVFDELRPCSRSDLSARRLPSCDCCIGCRPNLKLEEPMPQVSHDASVSRLFSNVGTGAYTYRSGSWLSDAGRETLARTQSENFGGELAVQLASCTCRSSSDASSTSEYSRFNGLNGLHHPSTSTTSGDASIEFHSGIDDEVTGESVDKKTRVRRSDSYSVDDLGSANRAPPDTNSVGPSAVNGSIGGDEERVTDYPLDHASSLPSPKVHRSNSPAETGDYTRSFSCRNAGDRELLSKISEVDCLAVYDPKHDDAIREVLFFDNVMCCGTFDCLHFGHKYLLLSAFLSCRSSMQIGVTASDALLSKKQNFSLIQSLEKRREAVERYMRVLRYLYGSRRMLSSPLLDHFANGSRVMSYHNCDFFAYPFTPVLLPDCGELSYSEYYADNPPHDAVPADSADALRPCVTTFELMDIYGPAAVLEETFALVISPESLPGAEKVNDLRRSKGLSVWPLLSSGFVLHPESDCTRKKVHKVSSSRIRSCMKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC62</accession>
    <name>A0A061DC62_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0304380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768720.1">
        <property type="nucleotide sequence ID" value="XM_012913266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC62"/>
    <dbReference type="STRING" id="5866.A0A061DC62"/>
    <dbReference type="GeneID" id="24565075"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304380"/>
    <dbReference type="OMA" id="RIEQPFK"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF18">
        <property type="entry name" value="RRNA ADENINE N(6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="9">
        <location>
            <begin position="51"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="338" mass="38448" checksum="8F933CA7C6635D93" modified="2014-09-03" version="1">MPLKQPKKRKDDAKTDTEGTGESQSDVPRLPAGEFRPKQSLGQNFISDKNIMNRLCSAFDRDEGGHADGRQVIEVGAGIGSLTHILYKKYRKMTAIEIDARAISQLSRNIPDLDVIHDDVLQVDYEAISKAKETKLWVIGNLPFYITSQILFCLVDYKRVIDTAVVTAQWEVAQRMVAKPCEFEYSILSVVLQLYCRPKILFRIPNHAFYPVPKVDSGVVRLDFKGTTNPPCAPLVLKRILRDAFNQRRKMLKTSLREFLDQLEIPRLPPDLEDMRPQQMAPQGFVALARWAQRKGTFKGDGARYGVHDNKRMHAPLGAADLDPNPLRVWRQERHGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC75</accession>
    <name>A0A061DC75_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adaptin N terminal region domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0304570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768740.1">
        <property type="nucleotide sequence ID" value="XM_012913286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC75"/>
    <dbReference type="STRING" id="5866.A0A061DC75"/>
    <dbReference type="GeneID" id="24565095"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304570"/>
    <dbReference type="OMA" id="AHIHAIN"/>
    <dbReference type="OrthoDB" id="364976at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="893" mass="98596" checksum="B6BADA70647ADF91" modified="2014-09-03" version="1">MLGLASSNMSREFYRFTKALGECRSKEEEERVVLSEISALKSLVLVKDVHRERRKEYLVRAVYVEMLGFEAPFAHIHAINMAQERSLVCKKAGYWACRQLLKPQSELMLLLINTIQKDLQSPNFADIVCALQCVCDLVNRDMIPTILPCVLRCLEVDNEHVRKHAMMAVRSFNEFDSTCVENLCGIIERGICDPSPAVMTCTLSLLQDEIATRPRGYRHLVPSLVSILNQIVDRRLNNAYDYHRVPAPWTQIAIVSIFGIMGKGDRRLSSQMFECLQSVVQHAEILPPAASVIANAIIYECVKTVSMISPRESLATMCSISVSRMLGSENNNLRYAGIAGLGILVGLNMSYAAENQLVVVSCLEDRDETIRRRTLDLLYRMTNSKNVTTIVGCFLGHLRTKCERYWRSELVSKISLLCEKFAPSATWYMETVLDLMMICPDLVKDELLFSTVNVLKENSGDVAFRRAVLRQVADLVKRADVLPEIVVKVVSWVYANCALCPDDVSGGECDGDDLTVAPGANCGVDGNDVELGMSNAAENDVADATVDTDETSHNDESHKPSDHATEVPEANQTGVGDGGAADEATDSPAENSATASDSTLSTGRSGQSEAGELAAANFDDYIDILLQFVLRYRQNNSTVCWVLGCMRTLIIANDYKVPDAVVSVLSQLECSNCTEVTQRCKEIRSLCDLRPQLNLRRNDYDSKLTFLENYVQTRIAGGARSYSKPSSEVASESAPAHLSPVPELRFEPYAMKPSQMSEYRETLTTEDLVNEEIICSDVPRSWGPSGYVDKKALQADDDDDTKVDPSAAPYLSGITGAAPADADRTRPTVVEPSIDMSILSLGSRAPKPAEPKGYVWKKPEPRLVSREQIQMARALFQGLDCSDEADDPSTASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCB3</accession>
    <name>A0A061DCB3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768800.1">
        <property type="nucleotide sequence ID" value="XM_012913346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCB3"/>
    <dbReference type="GeneID" id="24565155"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305170"/>
    <dbReference type="OMA" id="HINISQY"/>
    <dbReference type="OrthoDB" id="364477at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="434" mass="47729" checksum="5A7679FE212ECD9B" modified="2014-09-03" version="1">MINAKRVCNLFCRRQSALAASRLGGWSGRPSLCASTRKPPLRPSPLRLATCHYRSYSSATNDCEPSGSTPNSAVDGTGVDGSVGTEQPSTGHSEPVDSDTFVRLISSVNDRNSSFVVALQKFKDQLQADCSRAYPFRLRDLRTLLEFSSQLLGMQSDPHAADVISGAFELFKSDGDAAAAFHLCRLFSSFNNCLGRTMTSSVFQRVVNNRVGMMGAKFLSPKKMDNLREKLGPGAEIAMKFLASALTERDITGLEGCCEKSLFDFLNQGLGYLDRMGLKLKFEVSDVKDTKLDVFWLTIGGKRGNEISSPYLMKQALAHQILVELPKKSGSSSGSTGDEMPMNRQQNRELVMKTFEKGILARMEVLLTVRQSLSLVDSRGSTVWEDNKKIATHKLTFESEIAMRSRDGDDIDTKDWTVVDINGVLNSNAPFTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC2</accession>
    <name>A0A061DCC2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767651.1">
        <property type="nucleotide sequence ID" value="XM_012912197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC2"/>
    <dbReference type="STRING" id="5866.A0A061DCC2"/>
    <dbReference type="GeneID" id="24564006"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206230"/>
    <dbReference type="OrthoDB" id="366993at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595689" evidence="2">
        <location>
            <begin position="21"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="652" mass="69584" checksum="B63BB4CE665BE302" modified="2014-09-03" version="1">MKFVISLALLVFNQIHLIAAWETDSRHAGSKYGSVAAPNSRNMMSRTRKGFRVVTDIREMDGWHPELLSQRDMAFKNAFDDVLGRFTSNVIRTPYVRKAPAVAKPPVECTPDDVTVSDDTTASGVISTPDDVTVSDDTTASGVISTPDDVTISDDTTVTIDVPTPDIIETPDDLTISDDLTISDDLTISDDLTTSDDLTTSDDTTCPNAIAIPYPEYGDRMNPDYETVSRPATNDDVQKTLDYLKGRIAEGAKRSVKPKPEYTETEQESEGSDGFFSSLFCCGSGKKNAKQPKPVVIGLEGEPVRGVDGEPIDLPDNEELLDGNDDYDFDDIEDGDFDIDESQFFDGTPRTDGSNKIDDDADSGAVEGETIGDVADDQGYTDFDGEELEDADGVEVLDASEKIAVDADMETIDGIDGETVGDVVDTEVIDGEESVSNELSAADEEIGQVDGETGDADLTEAADAEKDYSSDHGEASTSDVDGSRASDVDSGAVDGNGLEVTEGDENDTFDLGESLPSLADEDQMKPTVSTSCATEAKPTKKQGGFGQFFANLFCCGSSKTHANDEEQITASVSKTVESSLRGIEEDDAPENAVSEADQSTVSEAEESAVSEVDDSAVSEADQSAVSEAEESAISEGGDDDEENEDKEEEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN0</accession>
    <name>A0A061DCN0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0403800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770078.1">
        <property type="nucleotide sequence ID" value="XM_012914624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCN0"/>
    <dbReference type="STRING" id="5866.A0A061DCN0"/>
    <dbReference type="GeneID" id="24566433"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403800"/>
    <dbReference type="OMA" id="KCSNFYK"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="306" mass="33850" checksum="D0FBED4F364AA20E" modified="2014-09-03" version="1">MAVLAFRTPERLLKRSAWRFTRRHLSDAAEYAALERVRLRDKTAHTLCRKSVELHSTGQRHSILLDGRLLESPLGNVLRTPSRAVAERVVAEWRERLGQLTRFETLPMTMLLAETVDMSPDKRASAVATLVDALDFDTALRFHPSPEAPLELLAGIEELDSACMSRIAPLDLDVLQSTYLLPILRAFARRRGTSALVASGDLATSPRQPADVVDAVRSTLTAYSAAQVVALKNIHRRLKSIVLPLELLDGAVDAARAVRASRLEETLQAASWGVCADFIEQECTMMSQIGVARDFWSAHVDSTSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ7</accession>
    <name>A0A061DCQ7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769010.1">
        <property type="nucleotide sequence ID" value="XM_012913556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCQ7"/>
    <dbReference type="GeneID" id="24565365"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307280"/>
    <dbReference type="OrthoDB" id="366084at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600800" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="8191" checksum="76B6358005834803" modified="2014-09-03" version="1">MELKRLCKLLITVCLTASVTMVRVAEGGVFSYFQGACDNVCQSCKFDCEKQYRAGTFNRWFCKGKCNAMMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCZ9</accession>
    <name>A0A061DCZ9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768026.1">
        <property type="nucleotide sequence ID" value="XM_012912572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCZ9"/>
    <dbReference type="GeneID" id="24564381"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209930"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="570" mass="63444" checksum="8D6AC1A9473DF4F9" modified="2014-09-03" version="1">MLSWLSGLQYTRVADKLPEHCKGLLNRCCHDGDIPNKEDPVMAKCIESLPLTIARTCSRSTTLLTAIHGNGHGFDLAAYPYSVDFSNNRARLHYPADPDALLDMLRDVVCRLCRVLHFLYSQCCRSTARVKGWRECAYGRQVQSHHWQCKQFTTYSSTSTTAATTTTSSSTSTHGCPPTSPLQSFLSDRCQGLLPHTLTASDMTIECTNCAANQPGQQCLTPLGFWDLGFAASISGTGWDLAKRLGDMCRDADSCLLVLCRTLSYLCPAAPSSLADVFALYAQVLRQWDHHDRVRHRGGTYSAAADFISHLNTDGIDSLFPLWTQLHGSYETHRLTTAIASLAGHDHKSHDALSSLFNDTTCKSPRGCAPYLQPLGLHACHSYPPKHAGLYVTWTIYLAWQFWELLASLLHALGNIDCTASGCATCPCKPGTHGGKDACHCQSLVKCGGPLPTFYRYGFTYRNANLLVTDNYAMRCGDLNTQLRQVLHSDHFTELFRRIDQLIWHIRMPFFYSLVALWSLVALYILHTFLYRMDIIRITSHLLTTKASHLIDVKAILTKGGKMLSLYDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD31</accession>
    <name>A0A061DD31_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase CHIP</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING-type E3 ubiquitin transferase CHIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0210580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768091.1">
        <property type="nucleotide sequence ID" value="XM_012912637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD31"/>
    <dbReference type="STRING" id="5866.A0A061DD31"/>
    <dbReference type="GeneID" id="24564446"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210580"/>
    <dbReference type="OMA" id="WAGVEHD"/>
    <dbReference type="OrthoDB" id="273087at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="229"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="293" mass="33921" checksum="2613A76E38434786" modified="2014-09-03" version="1">MGDVSQFNAISANDEWEVRQRRIQDAERFRNLGNESFKRGFLESAIDYYSKAIECYPDNFEYYTNRALCYKKQGKWQNVANDVRKALNIDADSVKAHYYLGQALLHLGEPEEGLKKLVKAKTLSEHYKVPFINEIEDEILRAKKFVWMNEDASFVQDLCSLKNYVEGAIARDAQGGTVTEEESAERLSQYRKVFNALDKARERNIPSYLCCKISMVGRTRHADIALQCIMKDPVVTSSGITYERELLEQHFKCNGEFDPVTREPCSVRNVYPNYSIKEAIDLFLKENPWAFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDC4</accession>
    <name>A0A061DDC4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769460.1">
        <property type="nucleotide sequence ID" value="XM_012914006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDC4"/>
    <dbReference type="GeneID" id="24565815"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311770"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7559" checksum="99605E1F4A88DCFF" modified="2014-09-03" version="1">MANVDEYECISPFMFLKDHERSTDALYFTPKLIILEYDIGLAITVIPTFTDAAVGYTNIATNTSYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE5</accession>
    <name>A0A061DDE5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0312220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769505.1">
        <property type="nucleotide sequence ID" value="XM_012914051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDE5"/>
    <dbReference type="STRING" id="5866.A0A061DDE5"/>
    <dbReference type="GeneID" id="24565860"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312220"/>
    <dbReference type="OMA" id="IDIHKTC"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="855"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1150" mass="127245" checksum="C8C853430206422B" modified="2014-09-03" version="1">MHMPRRRAPPFADGDGVKTPKHVRRPALSHSTASRSAISRSSVSSAAVSHSTVSRSSVSSAAINRSAISHSAINRSATSRSAISRSTASRSSVSSTAASSAAKASGRGESIPKQPSSCVDSKAGDVYGVSPQRQEGSQRTPLVFVNIHDKRELFVVPPDYPYKYSSAVAEGSVDDMVYPLLPKMVRTPRRTLVPFCGLGDYRGDSSIVSPLDTQLSQMVKRAIDNNDRDLLAVSPGKDSILSQVSLALPHLTPSQEHVKRRRHSLFAKQWKRNAINDCLYNFYASRFKGRDDATVKENVIASAAGNETAQRLIESALARKRHAPSEPKNAMTRNWISSGPVYCKSLSDVLKTYYEYLYSKQEGNGVLKRKVAATSRYFFEILAEAKDCERKMRERELVTEERLYGRKDFIADIERENQNNRNRCKKMYTMYLQCQKRCEEMSRHLRDRVAQQAAAMGPGPSPAPVPVPVPERVQPPPVRPGPHSAASHDITEDTAMNAAHVPQQQYDLEDCKTTAPASGPATGEGDREVGQMSQTAERLTQAESNVCHEIVLSLPALPTQEDLGTQSRNGGSASAGTATPSRHDFSCDTPNRDKTVISGQMGSSSAWDVATSAQNRSIQLVSSCIPSSRVRPRETLTPTKRLGDRSVTDSIANCSKSPSSAMAAGSRQGGPITPSFRCNSNSAREQDTPFANRLSSVGHVNKRIYSKMEEKGELEGYRALLSELNALLFADGGSVLGFSKLPPALSWLDETDNCRPTVPPSQENFRDGTLYTTCSYAEIKLMKVLQGGICALRSKNRSKDMEAAILQQIIDVNSELLELKKKLDNGRCALYKKLKRDWAERNSKWAGFPPLKRGYRLLNMLGKGGFAEVWEVLDPITLTVQAAKLHILSVDMNPVERGNVVMRVKNEIDIHKTCRSHKNIVNMKACFEMGDNMLATILELCDDGDLDHYIKLHAPVPEKLALTWTYQILEGLHYMKTLPEGRVHHCDLKPGNILKHRGDVKLADFGLSKMVPHHSTRELWGGGGTIFYQPPECLLANFRNKQIVLTDKIDIWAVGCILYEMLYNARPFGFIGGRRSLSGTQQHMQKLLYCITERMYQAILSGVKFPPNDRVSEDCRDLISRFLAFEPNMRPSIEEAMSAPVFHAELSGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDN9</accession>
    <name>A0A061DDN9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768611.1">
        <property type="nucleotide sequence ID" value="XM_012913157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDN9"/>
    <dbReference type="GeneID" id="24564966"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303290"/>
    <dbReference type="OrthoDB" id="10370765at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="27622" checksum="FFA09DCF374E81AE" modified="2014-09-03" version="1">MVYNSLTEAPRNLKEGIDWLVAVKGTDAESNIAALGEAVHKFLADKPVGSMQVPALEKIKLITKEFIGQKNLKGSWFVKNITKRVGSGLGKTYDTLVKDLGYVRDSDYQNVVDAEGVNADTIVENLNKVMDGTEKFLDDIKNPNQYTSAYSSKATWEASCAKDPEACAVVLVGIAPMLYTGLRHLRTASSEQAGLLQIFYGKKSLMNLLNAAGYNESECRSGISAGNVVNALRGVNDSVLYILYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP7</accession>
    <name>A0A061DDP7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769780.1">
        <property type="nucleotide sequence ID" value="XM_012914326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP7"/>
    <dbReference type="GeneID" id="24566135"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400860"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="7938" checksum="ADD3EEFF4913555B" modified="2014-09-03" version="1">MLNIATAITGGSDAIGNGLASFKERLSRRLLIGLTCQTRKNGCSRVTINVKRYFYRMCKLSAVKTARYHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDV2</accession>
    <name>A0A061DDV2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768786.1">
        <property type="nucleotide sequence ID" value="XM_012913332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDV2"/>
    <dbReference type="GeneID" id="24565141"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305030"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600827" evidence="2">
        <location>
            <begin position="33"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="159" mass="17272" checksum="89A70383CA361949" modified="2014-09-03" version="1">MWLAIRGTTGTWLMSKLMVAQLSVLRLRGLEGEDVGKGPIRLQRVGGEGECHPDGCKECKTRTCYCYCGLKKGSTASSSQRSLSQQHSLTYSSAASASGPVASSREEHPTLSPQLSTGATAATPVPYIIAPVALIIVVVCVMIYFRIRPFHRVRYLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDY4</accession>
    <name>A0A061DDY4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maf-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0305940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768876.1">
        <property type="nucleotide sequence ID" value="XM_012913422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDY4"/>
    <dbReference type="STRING" id="5866.A0A061DDY4"/>
    <dbReference type="GeneID" id="24565231"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305940"/>
    <dbReference type="OMA" id="YERTIVH"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="69398" checksum="54850691ECED778F" modified="2014-09-03" version="1">MADKTLMSLSKLFGGSGDDWILLASESDLRAYVLRQHLGITNILMLRSNFAENLKLEDGETAYDYTVKTADKKAEMVAKRFVEHEKDRTFRNEVRSPFGTVPDNFDFSKVKFIIGADTVAWCNDVVFGKPIDRTAAHDQLLAYQKYDPIMVTGVSIYVKDGEKSVKRVCSFYERTIVHFAILSEAQIVAYLDTEEYKGVAGSCNYTSLGETLVESIDGSYTAAVGIPTHQLAYELCNYLNRGTATQYLVDGAEAGEKVLRRRTKRTVGKLTQEVLTKENELTNVITPQEKASPSSDSESEEEPIEGGSEIGTTKSRRRREAQSQEPQETIEQGPVGEGEETEEQQEEVTKENESESEGGEDEDKEDEDEKEEESLSSDEEEAKKGDEEGERGEEGNEDIAQKSDEEDNKSKSGEDEDEEDKLEEEDEESSNESQPEEEEEEEEEEADVNVLENGAEEVPRSRNRRSASLSPEDESFQETAEETYNERSELENEASEDEFRSTDEADRESSNEEEFDIEEERREEVDSLTDETENGPEDVIEEELSSRPASPRMNAENEEQENGDEFNLEGEPERGVSSGHEEGQMLAEEEEPRDLTQEEQLPEGTEEMGEEEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDZ3</accession>
    <name>A0A061DDZ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769990.1">
        <property type="nucleotide sequence ID" value="XM_012914536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDZ3"/>
    <dbReference type="GeneID" id="24566345"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402920"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="245" mass="27111" checksum="899803220BA62A9E" modified="2014-09-03" version="1">MVYNSLTQAPRNFKEAVDWLMAVRGDGAKRNVAALGAALFSFLADKTVDKMEMPALEEVKHVTKKFLDQPELRNQWFVGGLVKRYNDLINKSPGGLAKYCRVVDESDENVVKGKGITAGSILYMALRFLDDIKSPGEYESAHSPEATWSKSCTQKPEDCAAVFVGIAPMLYAGVRSLHYASIADTLNWAPSTEQEFSLGKILKALGYVKPERRTGMTASYVGRALGGFRYETTNFIFDLAGFWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE43</accession>
    <name>A0A061DE43_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S28, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0404560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770155.1">
        <property type="nucleotide sequence ID" value="XM_012914701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE43"/>
    <dbReference type="STRING" id="5866.A0A061DE43"/>
    <dbReference type="GeneID" id="24566510"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404560"/>
    <dbReference type="OMA" id="NTGMHGE"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000180">
        <property type="entry name" value="40S ribosomal protein S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7487" checksum="7D39A6E34A37CD59" modified="2014-09-03" version="1">MEQPKLAKVNKVLGRTGSRGGVTQVRVDFMGEGGWEGRVLIRNVKGPVREGDILALLETEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEP5</accession>
    <name>A0A061DEP5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytosolic glycoprotein FP21, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0401320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769826.1">
        <property type="nucleotide sequence ID" value="XM_012914372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEP5"/>
    <dbReference type="STRING" id="5866.A0A061DEP5"/>
    <dbReference type="GeneID" id="24566181"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401320"/>
    <dbReference type="OMA" id="LHIEYSC"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="4">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="3">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="208" mass="23902" checksum="04B93BE1BB73BB52" modified="2014-09-03" version="1">MNVQLISAEGDVFTVERHVISLSVVLNNTLQDYDDSSELEPIQLPEISTRILGKIIDYCRYHWDNPAKPIPKPLKSARLIEFVCPWDCEFVNVDKETLFELIMAENFLDIKPLLDLVCAKLASMIKGKSVQDIRDEFNIVNDFTPEEEARRCCGVGRCMPADRHSERSDGWDHYQMVMRIIGEKYVAIADAMSFAVTIREENKWCAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEQ1</accession>
    <name>A0A061DEQ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin 4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769856.1">
        <property type="nucleotide sequence ID" value="XM_012914402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEQ1"/>
    <dbReference type="STRING" id="5866.A0A061DEQ1"/>
    <dbReference type="GeneID" id="24566211"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401620"/>
    <dbReference type="OMA" id="GHKHRDG"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="153"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="380" mass="43285" checksum="1AE4F9107C34286D" modified="2014-09-03" version="1">MESASCDAAEVGSSATVVDSETDRILRNYGCDLIQKAGILLQLNGVTIATGQTILHKFYFKRTLREFDIRAGSASACFLAAKLEENMRKAKDVARVFDYLINNEDERRCPTIHLDEILSDEILRIEREILVEFGFRMGGLLVCPHRYILQYVFALFRNVGEYSANGVNDVAQRAWGYLNDSMRTTLCCTTTPSVIAVGCIYMAATSLGIPLHKVDGWFVVFDVKWSDIVMVCEELERLYSMGRPRYVNLSGVSCGPIGEHTGSDSGVMDKHDSPQKAAGTRCGECVNTYNSSSVSRVGKSDAENPVNETSDAARASRGDNRENERWYDRYRHSGKNDRYSRGYRRYESDDARRNYSRGRSHRERHYDSYDRSDYRRRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEW0</accession>
    <name>A0A061DEW0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA primase, large subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0404520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770151.1">
        <property type="nucleotide sequence ID" value="XM_012914697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEW0"/>
    <dbReference type="STRING" id="5866.A0A061DEW0"/>
    <dbReference type="GeneID" id="24566506"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404520"/>
    <dbReference type="OMA" id="RINYKPW"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="10">
        <location>
            <begin position="319"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="497" mass="57117" checksum="F6289FB64373F9C0" modified="2014-09-03" version="1">MSEVLLHGDAVSSELYRKCFFKGSRHVVCFYNAPPLEGEINLRSFQEIAAKRVALLQFIESRTSFRHKRSDPKVDHVPDIEAKMEELGFMLPSPVFDQEDVDKFLPIAQADVISHFVLRLAFGKARDRRDWFVRNEQRLFDFRLDRLREVKIRDVETHSKLEYFLQSQGIVYESVVMPTVFSGANSKNEQLQEFHQLVSFRNDAAKVDKLYIAPFYPDAMQLVRSRQVVLKNGLAYVPNTVLHVLCSSRFRHQVVTSFRSLDESGGFDSAPPFVDERLSGFLRVLPESYLAVDHSRSSFKSDGSESLSLANINSVFALTFPPCMRRIFTHYIRSRHIKYNARRQFWLFLKGCGMSLEENLHFNRNLWDDPTNFEKEHVYTIRYMYGKEGRRVSCPPLSCASILRALPVPTAGQVHGCPFRDFDSDGLRGLLEDFGLNAEQISPIMELKSTHQYQLACMEYFSQTAPNGSTEGVGTHPNVFFRNSFKLHYGSTDSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEX7</accession>
    <name>A0A061DEX7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770236.1">
        <property type="nucleotide sequence ID" value="XM_012914782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEX7"/>
    <dbReference type="GeneID" id="24566591"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405340"/>
    <dbReference type="OMA" id="WPTYYVA"/>
    <dbReference type="OrthoDB" id="361454at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="240" mass="26552" checksum="0A8E74937F067A7E" modified="2014-09-03" version="1">MVGLPESRKQAIYCAMGRTIAAATFWATFCLGTGAFLPAAAVRPTAVLKHFDSLAFNAIELAKIFGRLSDPSPIGSVLKTPNCHVAGVDTRRPCKWRSIFDHDDESLSRSQFSKRLAAAQLDWPTYYVANRQPLFLVPERQRHKFKLKGYLGNVAIDTPRVGDAKDGSAAISGRALKSIAEQPLEEEAVDSVFMALSHEEEKLTINHILAFIRYRSPLLRMVNWEAFLASLPVGPDDIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEY8</accession>
    <name>A0A061DEY8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770291.1">
        <property type="nucleotide sequence ID" value="XM_012914837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEY8"/>
    <dbReference type="GeneID" id="24566646"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405890"/>
    <dbReference type="OMA" id="IMLCENN"/>
    <dbReference type="OrthoDB" id="361370at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29273" checksum="02D39ABAB6302DF3" modified="2014-09-03" version="1">MLKYVIFDNLTDEFVYLRASQRARSPPRKQRVKRAIQQRKYEDVRSLLRLVAISESASTCAVCNASFPLSSDATSHFACQLCNETCCINCKRDVLLQGTEHEAPLDAIMCKFCSEYVMKLQSSVTQQPVEETFRRLINSFTYTLQLYKNIDASLLQLQGYTKLCALHQRLKEPLPDGTKEKIHKLIDGVLSQRKEIDGIKNGVDRHSLERTTTNLQQSRASRVHAGIKRSLLALSRGVLYKTVPRISEVVGNLMQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEZ2</accession>
    <name>A0A061DEZ2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0406090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770311.1">
        <property type="nucleotide sequence ID" value="XM_012914857.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DEZ2"/>
    <dbReference type="GeneID" id="24566666"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0406090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0406090"/>
    <dbReference type="OMA" id="HISTEHI"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2370"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="871"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1289"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1310"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1477"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR98125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2447" mass="260748" checksum="3107D35DF88D33C3" modified="2014-09-03" version="1">MAERTVGFLFKSLKDCLVFFCWLHEGDGKVYLEPVISYLHQRVSKYYNWIDRTSIQAELSNFLWHVNRVYGKLVFTTTKDAASIPRDPNVDDTVDALLECLPKFFAAMYYLWYNVDVIFKGVGGGGWAEDWPGYGGGLETYLTKAYRSASGSILPGGFELRELRYGRLYANYTQGKKMTTDLRWFLDKKVEQNYLRDVFILSTCTVFGAESVNTANAICLVGVFCDIVKSGKQDALKEALEKNIKPKCIAWDELKHVCGEIKVTYNNMFTTGPFDHSGVATTASYLRSEVFAEKFAAWFRTNFTNIIKHVETMRNQVIDTGAFNYRSFANGVLFPNGVVFKGNDVVQAKGFLDTWEWTNALETFVDDNSGLPKLKELLDGVPCPQAPLHTASSSSTSGAKGTRSVVGNKNRADGSQTTSGAIRGKGGGEGASHSGSGAKLSATQVQSVAQSRTDSTPSHVQASTAQRTTQSQPKSAPQNAGNSDSKRVEDTKYTGGGKSPPAPSVSVPQNHATSSTITVQKPDIPSLSTQAKADHIALPPAPATLGPSSPAGDLKNHVDVLPPTGKPDVLVYSSIPNEKTRQSLSPRRDAAGAADTHATTHIAAVDGGDGIGGNGTAGETGRPGESDSAGRSESPFHAPPAHPQPLPADSGTTTATEASMSPVTYDKVPVESPNKPEVPPAKSPGTPITSEGEQDQGKDPRVDVSLGSQVQDLAPPSPPSGKGESVPTGSPGVNTPQGPTSAEPTVSYGSSNQNSVQDQTVVVSQPPPTGDAVSPGSPSRSIRQGVGLNGDAHSGKQLVSSPSSEPPQSSNGQAQQVVQLQGPIEPSTSIPAPPGPPGDQGRGSQGGASSGQQPAVSTDTLVAQSQRVTDSVSQPSSVIAPSAVSVTDSGQGDSQHGQQSGISNATESDSATTTTPPSQGSVPGDGGASGSGGDARGSTDGDSKENLKSIQAPTPSDSIAASTSSVGSGLPGSPGLTPISSPQENSHDQGADKSAKSTTVSEHHTSDLAGGAVAAVTKAQQIVDNEGNGSEGQPGVAPPVHSPPPTAAPPSTPETIGPGGAAADRSTGRTSIVSQGQGIAAYATNALPQPPSAPDTGFTSFGTLGRGIGPGLSGRGSTSELIQRSDQSNQTDQGADTSRHATLVPGLSGGGGGGGGGQGLNSHASPLSTAAPGVGVTSVDPMASGLHPASGREGSGGHTSLASTIQKPRAIQFGRTSTPPIDPTVLNGYEEDDEANGRGGDLSKSQAADAMNQVSIGQDHGALQAPGRQIPDVSTSESSPFSTTNSSTGVTQFSRTLHTTVNLDSLGSDTEQDEDTGGSDDDSGVVNAGTDLHGPQSEDVSVPRGVGNTGSSMSKDAIVPELGGLKQSAQDGFHSGSPTGSASFQAVVSQHLNPQSSSTISSGRGPATVSPAPIAFDPPTTQPSKSGPSSPAPLSPVSESNEQIDKHPVTLGGGNDEDPKTDIGSFGMPSTGEPPGINGGGSSVGTGQGGTNPMTPQIGGSNLSLNTSVNSGSNASHQVPSQVLKQTPAAITFTKITDDQIWELQKQSMHGENYKKLQQKIKQRSDAKQRSQIIPNLKKHVYHTDSYASDARSGGFTRFSPQHYVPQKGQQKPAVRNDVIINGDAIEDPFYENDRKQRERVVAEAKRKEDVRQMKQTTDESTWMAEKLKFADEVKEHKLNVTKILQDIKQKDLDLMQSPQDFNCIVVSDTSKAASDDLYGKVVHELDGKAMTYDNVIQDPEEKRMEDLYNRIMEDYRTEDNTRNVMEKMKEEHRKEIEKFNREAEKDYNVAVEQNRIVHALANSISLDDASSIPLMENMTPSMSFLAEFDGSATADARGSSPMLPLPQSDFDIEMAYKPDRSDDNDGFRNHPPPAAAYKINAPLSYNYPDISSSSPYLETFDEESLKSPTVDFCLPAWTTHTPTDDFDGIPEIELFPAEAPRTIRDMLRWLVGIGSQKHLTTLDKCINEAFGKAPDVIPGNPTLCVNNSKLKSEDVIKALKLASMFSSSVLSAIEPGWKQKSSRSGTVKRMDTDHDQDPDGCALLCCLQDYVYACYHQLAFLRSQCAGDKFRGGWMGCQFGRDVTAESPLQAFLTDAYYSKFKTHLFDPCDVCLKSRIRMGFRKGDFSKIAKDGSYLYYLLSPSCSGDDDPLITLSSYLNCITRRTPRTTGELVSFFQHFGSEMRKDGIGILSDMGRALSTPHPNCPEWDHLGRHDLDAVGGIRVSESPISKHDNDHAGTLSTLVGCNITNVQCTKLLSPITHRAYAMYSPCFAQTYLSWVVYLADTLRESLDRLRYDFTRHNVSKCGSIHHCHDALPYLYFHGFTPPEGTSTSLVTCSQVITKLEEVINGGPIAKLINCMDDFLYRVRWPFIYTVITLWSTAFLLFAHTALYRLDLLRIQSHFLRSRGSHVIDVKALLTDGTKMPSLYDIDYFDDEALAHAWNRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYP5</accession>
    <name>A0A061CYP5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765937.1">
        <property type="nucleotide sequence ID" value="XM_012910483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562292"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100800"/>
    <dbReference type="OrthoDB" id="366448at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1307" mass="142460" checksum="3BCA907F1C34DF1A" modified="2014-09-03" version="1">MNGGNFNLRLNVVHRIIPGNVDTEEDARQYVENLAGPGNKVEDLLSRSEHIEQISSDFIQLLEFERSWTPTTGEDATHGKLLYEVVRNALDRDNQSAALLINRLYLRGFAKELIKSVLLYYGINSSPRRKLSCRTKLEGRLKDASSTVRICSGALRCISKTIDVQGERGARRLRFKSNLDYNVAVGVTTLFLDSAVVVDDAVNYENVLQLLHPQSQAAVPIEMQLFVLYVIGERIKGEGVDEAYSDNELPQNAINPSPQLEGNEDAQETQNGTDATDGGNVTHVTGKLPPLYIKGEPASGSGKHGTSAGETSPTSTGVTLGAKKDCITSQERDLHTEVGRKLLWRLAVRWSERNVNASGQETDYVSLAACIIKLLDIVYATGDNVVYQDFDRVAMAISAGTSAKLSTFNATQMYAAIEVAKKLVEITTQMNTLLGIEPSPDLEFTGSENLHEKPLVYLKLACAPFTVETSGRLYRYNSATNELENAPPAALLETDTGDASIPSNDVAEQEHGADISGTNISTAVVFQRQSIDREDYATTGLTNNGEERAYQLTANPSGSVGTANDGGENSYAKRHIEDLVDDIFADVPRASAPKLRFLPTRGWMDPPLHIQQCYERLRNIPVVADVQPDKLFNNALNKPQTLSNLRQRMMVAQTLFYLPMIVDRNEPMLEKYAVSIYQMLVKIDDFQQYNDLMAELMGKGTASQTVLGEGGDRGVVEHHGGHADLPRQVAEKQAILSMISIAALKPIKICEFVCKAVADTEYTVTEKVKMLLSMQKAILTISGKASEELEQPSGSSVNNISKRSDVDIEGGRNIPLIAFRALRRNVVRRPPLTEVSTRSAMPGSSSGSTTNNEDVDEIAIGGNVGAATHPIVPTLAANHNDESALDVESGTGADANGSAESCLPTASRLDEVNCNVKTSGSKQQAGLSQGSQSRILSGEPSSKDPHASHPASATICEDGVRPGMARTATSNIQKIISGDRGDSRTHEHMDAVSPEFISTAQTSTCAGGRPSSDSSVLQGMLNITNGESHSTGIRGRSIALNAKKPHILITPRELNVQPSITAENDKSTTRGSAASNQRKFDENELAAIANVSTSLIMQTIQKHMKSGVAVLSAGPEHAVTVSLLDTLHTCLRYCGGSLSPIVIHDCALMIGQNHYRSSSHDVVLCTNFCKIDATQHYVAYHIETSSMHGNYAEISIGKCLSTAKQCKNGDLESMLFKAGKTHRQLNPCSITLINSQYYTIYLGYVRNETAIHYRLAIYEYYDELWSSQFGSAHLYINTYSLISRRFTIIRHKVFIWLAAYASLPIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYZ2</accession>
    <name>A0A061CYZ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765859.1">
        <property type="nucleotide sequence ID" value="XM_012910405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYZ2"/>
    <dbReference type="GeneID" id="24562214"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100020"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="100" mass="10995" checksum="6B8A95961DC21F80" modified="2014-09-03" version="1">MAVRGVAPLQFSKSVSYKVTHCISRCRSSIHMILIPVVKCKKVAISRVVQGLPSCERLMAAFGLSYSEHDDYLLVFSAASQFEASGMAPKSLMDCPENLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ27</accession>
    <name>A0A061CZ27_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0102050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766062.1">
        <property type="nucleotide sequence ID" value="XM_012910608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ27"/>
    <dbReference type="GeneID" id="24562417"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102050"/>
    <dbReference type="OMA" id="RTEICKA"/>
    <dbReference type="OrthoDB" id="20534at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="227" mass="26348" checksum="50C103D8AD621E4F" modified="2014-09-03" version="1">MEQSTGLNKMALSCFRTKQCVHYLRGNCNFTDSKCLYSHQSICVRRCPFYLSDTSYIRYLPLLCRNVVFGPKFEVIEMNCPHGNECVFSHCIDELLYHPNFYKIIPCKDHLLGFCGQGYCPFVHDKSEQRALRHYKLPFAKGVKIPHIKHITVVDRIVRKKPRTDARKPNKPSRAPFISRASTCSGPKEESDCFDEHLNRLLMNMRLTPLQGPTRQDTDVWNGLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZD4</accession>
    <name>A0A061CZD4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear transport factor 2</fullName>
            <shortName evidence="2">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0101070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765964.1">
        <property type="nucleotide sequence ID" value="XM_012910510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZD4"/>
    <dbReference type="STRING" id="5866.A0A061CZD4"/>
    <dbReference type="GeneID" id="24562319"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101070"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="124" mass="14100" checksum="5CA868BC01B7084F" modified="2014-09-03" version="1">MATGMNPQYNEVGLQFVRMYYQLMETDRKSLANFYNEQSMMTFENSSHCGRDQIMEKLLNNPSSKYSILTCDCQPSPNNGVIAFTMGDVSLDNSPPMKFAHVVQLFPNGNSYFVLNDVFRLCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZL3</accession>
    <name>A0A061CZL3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766019.1">
        <property type="nucleotide sequence ID" value="XM_012910565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZL3"/>
    <dbReference type="GeneID" id="24562374"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101620"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="71" mass="8275" checksum="294294CFB88B453E" modified="2014-09-03" version="1">MTSHRNRAASASLGRQDDNSFHHSLHYDYTCLGSAVRMCLIRTVHVVKWAYEYQNANDENQYHNPSFGSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZR5</accession>
    <name>A0A061CZR5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766297.1">
        <property type="nucleotide sequence ID" value="XM_012910843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZR5"/>
    <dbReference type="GeneID" id="24562652"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104200"/>
    <dbReference type="OMA" id="SKCFVYP"/>
    <dbReference type="OrthoDB" id="341684at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="27798" checksum="E068BE28C19D823D" modified="2014-09-03" version="1">MAITNTPVSLEELKVAITQAYPGIEHRLKNTFIQHDVAAEGQLPYGVVEPLLRHFLVECGLDDYMGEVTHAEGILSHCRVSAFLVGTSLEDVSDSNVDRMINCEEMFILAVVWLKVISDMYQRENALNNAVCGSLWCGAGDMRQVEVAHAIGNEASFEQTTSIVDGEMPIIVEPRYVDHVNNAADEKELTQKNIEHYIQTLVNEAAANRQKGVKCFVYSSAITTNGGCVSAGAAIPQRRERVHSRRSATTGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZZ3</accession>
    <name>A0A061CZZ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">5'-3' exoribonuclease (XRN2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0103100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766174.1">
        <property type="nucleotide sequence ID" value="XM_012910720.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061CZZ3"/>
    <dbReference type="GeneID" id="24562529"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103100"/>
    <dbReference type="OMA" id="VYINHNE"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="8">
        <location>
            <begin position="760"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="7">
        <location>
            <begin position="1287"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1389" mass="156681" checksum="65325335B466D028" modified="2014-09-03" version="1">MGVPGFFKWLAQRYPLICETYRGSAAEKDDAFKLLRSFEADDHSGQAQNVPEGFDNLYIDVNGIIHNCSHSVEELCQGIRCEEDIFVLIFQYINNLVKIVRPRKLLYLAVDGVAPRAKIMQQRDRRFRSARDSKHNDVVFKAVQEELGCDNAQAKAAEGGEAFKFDPIQITPGTLFMERLSVRLQFFANMMINDHKAWKNIKIVVSGSDVPGEGEHKIAEYIRNNKAQRHNEASAGGRACYVSHCIYGLDADLILLSLATHEPYICLIREQIYFTNRQTSSRMMMNMNDYIFLHIGILREYILNDLLQPAQLRKSPGSIDRVVDDFVLLSMFVGNDFLPHGKFSKIADGGFNHFINYYIRYIERRFSESPKADLWLVTGCGEVNYDNLKMFLGNLVKHEASCINSELGGGHDEANRSRGRSSNKNAHGEVTVIDVENCRIATDTTEFMAKYGKQPKLAAEWKARYYFAKMGIASDVILLPDGADRHNPNGPPLTIGEVVHDYLEGIQWVMYYYYRGVPSWSWYLRCKYAPLLADVQKFLKTDVIRSKVMRKGGVAMGGPVTLSTAMGIKFALEEPCTPFEQLMMILPPDSAYLLPSIFANLITDKESPLHKYYPEKFDIDMDDTNVPWGGVTLLPVVPLVELRILMNHVLLGDEVANIDKNVGLPRKLYYIESRRLTEDEKCRNNVGIARIYFSNPESQGTTVNSPMTVFGNIVGCKVEYEPFFNPTLKRGQTFPTQLMMDSRHAEDGQRDRYLGDNIWFPSLSTLPFTPFTRSGVNVFQIRSHLPSMYLWIRQPFHHNAVRNLMNAARAKYVTVGYPYQHIGRLEAIYTPYVTITNGRLHVGSPQELVALLTSIRQNLSKRGVIVSHKSPEPSIDDANYHNYVKMSRKLLYKLFDGLPGCELSNDMPSVRNARSLKLDLLCENVVVKYRVVDINLQDTERTEHSLLTFVRFIDHVSEGVPQMERAVVRGKAASSSQVELSNNLNEMIALKSAIVQHEMMYGRYSKPLIKAVCIMKGSLYGAVGSIEKVGNSFDNISAVFSIPDYRVTIGENALQMYQKHQKITHILEGREQVNWYSFDQICRMTGLSTATASAIFHLLACGKHASDIGMHLALWSDEKSCVMCLPGYTRCDDTVLTAERMSNPDSLLRGVEYSSKVVALVEDYRTNFPELFEHLHKNAGKANSTAKGEYRHHVNLDGVFVGSPELVEYKKGQLAHYVSSQVFRRLKLTIGNYRCLTPSDIEGITNTYDQDPGSEDGASCKLVRVSHIRNLHIPSYNTGTVFTHEDSITLGQCVVYINHNEVVPLGARGTVVGIYPQNSSGSGRLFEVLLERTFVGASDLFGRCGMMRGIIASVADILPLYDEAIPDQAMWSASNQSNDRANAHYVSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0J0</accession>
    <name>A0A061D0J0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0104920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766369.1">
        <property type="nucleotide sequence ID" value="XM_012910915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0J0"/>
    <dbReference type="STRING" id="5866.A0A061D0J0"/>
    <dbReference type="GeneID" id="24562724"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104920"/>
    <dbReference type="OMA" id="CRTTHEG"/>
    <dbReference type="OrthoDB" id="366088at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="383" mass="44028" checksum="5764FC8CBB069465" modified="2014-09-03" version="1">MSSEVSDAYRVKWMRHFSRVTPFLQYSTAADSLLVCVGNILLLRRRIQINSGTYAISFDELCKLLLTAVRRAQSEWVLDTLDKMRRIKKGEYTLKSHTMVFDDDVKKLIDMLGINVFHGCVAGPRYKNIESFSFEDLRYHIMLYQRGQRMEGVRFDESEAMSAETFLKKYPSKLTEKGLQLLRDEFCNKEFAYHGIYHNNRFLTLTSNDDTLLTLMADVVYEPHGCIWEELERPVYLDERFKPYHIDQSQIKQPTPLSTPRMSNDVNVITRPLKPKVPIIAVTNQQVRLCRTTHEGSCTVECMNKIKEDATRDSSNATDPVAPNEGSVPDMQQSPTDQNQGDDLKSGQTLTDVKERRHQTKCGCLGFNLLKIFRNKADPSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0L8</accession>
    <name>A0A061D0L8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0100210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="bbig:BBBOND_0100210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100210"/>
    <dbReference type="OMA" id="CDPAIIV"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2897"/>
            <end position="2918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2138"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="615"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="856"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2138"/>
            <end position="2148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2969" mass="329778" checksum="599EED9D346B614A" modified="2014-09-03" version="1">MDESSAHDVISRLSTFQSTLPEDSENPNKNILYNLCTSAGSLLGYRYPGTYDGSEIVYGNASRLCDAILAFLYAVFSDVRDNQPYVAGRDVLHDVIVELKSQLWRGHKGLSQVIPKVATGLRDYNATVKASNKKVKEPIETVLGHVKPDGELRKGIQALQITETSKSAEDEQTVESAVFLVEGCKEVARVFSKSLTAAKDAINDLNPKLKKKLENARRSFFNHVDWLSKWSKKGEKKRLDKMVQKIKSRLKQLAKGIKMKLEGITAGLEEYVKELGQWMGEAKEYINAVKTYVDEIMKQLDGEHRKAIDQAAAEIDSELGKKVEELNGWIEKAEAAVNVAKKKADEVHKRLDKDENSGTKIRQGFEKISEAKDAVSGVSTQLETVHKDLGDWKTAAQGVISKAAGKAGEVSGQLDPSQKGDGNPIGKNLNQIDASNEDIKKANESLRKQTEKLNKWITEADHIREQAQKKAQEVYDSLKVHDELSNKIKEIQTANQTIKDVNSGLGDVDSKLGEWKKEAERVLQDVVQKAEEVYAKLDHGDGQQPITQGIKQIKAAKANVEAVDKGLTSVNDDLRKWREAAHTVIGTVVEKAKHVHEKLDPAKDKSTLGSQIDAIDTARQAIVNANKELERQVKSLNTWINEAEKIRAAAEAKAREAYDKLQVHEKLSENIKKIVDAKNKIDEVSKHVTGQLGSLQQWNEKAKGVVDGAIKKAQEVHDELQSAVVQKVEGIGQDSNAIKAASENLGKEVEDLGKWKNAVSNVIVKADKKCDEILKKVKTSNDGTIFTQAKELQDKGKQLLTAATEARQTVESKVKEALDAVKDMDADLKRDLKVVKDNIKLGIAEVIESLKVGDLGDKVKEDLVKLRERIMKLAENGRVESLVEKELAELNQKKSETLDHAKQKLTEAEKQLQSMFESAIKTPLDDKVKTVENAIEKLCEKINPDGGDASREDKMKFQTIFDHIKKQVGVIKGTGTKSHESGIDGIVANVRGLYNAFVDSRGSGVDARVDGWLGSILGINENQRGTQTDGMKAITAYIERYKTREDALKVVKDQIKEKLGSQIKAGQAKISSQDVKDTIVENLRKVKEACEAFVEELDKKLMKGQIESFADPIVNKIPGLSGERTRSSGNAEHPKTAIRAALIALCSCVRQVAAEVDYLGIKLFGTIIDQIKPTVDGLHTNLTHATEPTESGNANPPDGTAQAVDKAIGDAKNMVGTTMQQKFEQEVKKPVETAIQGFDAAVTLYDTKARQQVKDAAKGAIEEAAKVISADGGSDIDLGSKMKNFHDAHKEITTNLKPKLEKLLNDHIGKDEIPFVGKADRVKLSKNLEKYLKHISVGVLTKHPHGPLAEAIDKIGGEGMKELGVIHPRHIGNDKIDEQTFENPFKAIQLQLEDITKLVSNTRAYMTGEPASYKNGIKNYLEQLKNALGDGKLAGADKGVDSITKAIETLQKQKFDPNSKKIEEAVKAIKAKVEELRKKLLNDNDPRGVIDDLKDLKGKGLAGGTWEGKDGLGKIETELHEQNKKLSDETKIIGEAIHEIKWERVKLGFKLSHPLIPDDILEQLEILANMIGQSKYKHDGTLQRIHDVISELWAQQFSKNPNKIGRATKAITGRLKKLLAVLEGDADKDVIKTIKDLRDVGLSKNLWEKHGSEKGLQQIENDLQRQQKSLTGQAKQIDAGVKLITTVLDELRTALQGSSGNPKIDVIRWLRELLTKGLNGTEWDTGKGKKIASLGQIKKDLRGQNDKLAAATKKIEDATNTVMSETQDMLRKASQKLSGDLISDTIVKNLQLLEKMIGRGQNGDSESLQAIQKVISGLQAQQFDVRSKAIEEAKHKVEHELTRLEGELVTHVADPLKHLIQQGFGNGDQWNGNAKGFDNINHHLQRQQETLSQQPKDIQGGVTIITTELDELRTVLQGTANDKPENKGVIKNLEFMAKHIGEGDNEGLKKLKSDMESLKKNQGQDITNNLDQLSRDIQHAAAYADWHVTHLENPHINGKLKGIQDGLDNLRLTDLADAIRLCDNFLNDADEIERNTVQALWKHVDDEVEDAIKDLTKEARGLYVDSVREALALFAKKVNEDLEQLPNEINKDMYVGYKGFMKYLQGPLSSDLTGHEQSVAELSSAFREVFEQIEKITRLHDEQNKEKNPSLPPTEDPYTPKLKDVYDALTALLAYLRDNDDGADKLTELVERLTKALGDFVPSDFKHPCTPLLDTVARGLTKFAGEFGNCYISAYSGQRCREERAHKYAKVLLSLIPMTHNALNKLMMKCEGEWKYLHISKLTADYRDNPLGYYLTRCGYRVSSGDSGQDGELNNMFTGGAIYELLTTRIEGVSIEMMIDGDPIKNGISIVTIISLLYNVLCHYFQACHITVPPEPRYPCTVRDMLSWLSGLQYTAVVDKLPEHCKALLNRRCHDGDTPNREDPVMAKCIDELPYTIASTCSYSTALLTAIQGNVHGFDLAAYPYSVDFSNNRARLHYPSDPVELLDIVREIVCRLCKVLYFLYSQCCRSTARVRGWRECAYGRQVQSHNWKCKQFTTYFSISTTTAATTTTTTSSTTTIHGCPPTSPLQSFLSDSCHGLLPHTLTTADGTIECANCAANQPGQQCLTPLGFWDLGFAASITGTGWDLTKRLGDMCRDADSCLFVLYRSLFLLCPAAPSSLAAVFALYAQLLRKWDPHDRVRHRGGTYSDASDFISHLNTDGIDSLFPLWTELHGSYQNENLTTAISSLAGHDHKSHDTLSSLFNDTTCSSSSGCAPYLQPLGLHAHHTYPQKHAGLYITWIMYLAWQFWELLCELLHALDNIDCTASGCATCPCQPGTHGGKGTCHCPSIVQCAGPLPTLYRYGFTYRNANLLVNGNRVMRCGDLNIQGKKALHSDHFTELFRQIDQLMWHIRMPFLYFLIALWSLVALYILHTFLYRMEILRILSHLLTTKASHLDAKALLISSRKMLSLYDASYFYDDPIGQLVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Q8</accession>
    <name>A0A061D0Q8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765908.1">
        <property type="nucleotide sequence ID" value="XM_012910454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Q8"/>
    <dbReference type="GeneID" id="24562263"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100510"/>
    <dbReference type="OMA" id="NICTLYK"/>
    <dbReference type="OrthoDB" id="328211at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="37400" checksum="82C6E78499E61F8C" modified="2014-09-03" version="1">MATLHSRIHRLPDEVATPQIPVAGKPFLQLCQLDPCPLVLTFALHHLLRNYNFFVNYSCSARSSRYIILCYMIQMILIGALLLVTILLGRLCNLFSNYSLADCTYSKRLINILGFTIKWLPSMAGMLMFALVSLQFACLVWTLANSRQWCFNRFNESAVNAVKNCRIIHQQRAACKLNFTITTRKEIRECNNPQYLIKKRIIFLALSDEDKGCTIEDIAVCNALAKVFTNEAATVMSAAKVDWNSPQLVGCLGRLPEAYEPLFDTVNPSDLYKFLMLFNIMGTVFNALIVIFFYVVRYVTVFDAVIYQPRNSNDNIAIKVMRPITMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1A4</accession>
    <name>A0A061D1A4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766073.1">
        <property type="nucleotide sequence ID" value="XM_012910619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1A4"/>
    <dbReference type="GeneID" id="24562428"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102160"/>
    <dbReference type="OMA" id="VFVLMPN"/>
    <dbReference type="OrthoDB" id="328138at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="139" mass="15787" checksum="95722158A20656E7" modified="2014-09-03" version="1">MGFEWSRRPYTAPFLRDLVYNPNHRMPEADSGEEPHRGEPIGQYRFIKHVPFARRVSALPLKDSQSGHLGDTGGCSSTLNLQSLVPSTAFGNQCGTEIRGTDIFFLPKPTQLLFFALPVFVLMPNLTVFTRHWFFYAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1D6</accession>
    <name>A0A061D1D6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dim1 protein-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0109140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766802.1">
        <property type="nucleotide sequence ID" value="XM_012911348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1D6"/>
    <dbReference type="STRING" id="5866.A0A061D1D6"/>
    <dbReference type="GeneID" id="24563157"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109140"/>
    <dbReference type="OMA" id="GMYELYD"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="153" mass="17852" checksum="2AECD7C64D3EBD73" modified="2014-09-03" version="1">MSYMLQHLRSGWAVDQAIMTEEERLVVGAVCGGYSFQCIRFGHDYNYACIKMDELLYKVADDVKNFCAIYLVDITEVPDFNGMYELYDPVSVMFFYRNKHMMIDLGTGNNNKINWAMNDKQELIDIIETIYRGARKGRGLVISPKDYSTKYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1U8</accession>
    <name>A0A061D1U8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766288.1">
        <property type="nucleotide sequence ID" value="XM_012910834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1U8"/>
    <dbReference type="GeneID" id="24562643"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104110"/>
    <dbReference type="OMA" id="LCIIRQH"/>
    <dbReference type="OrthoDB" id="364489at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="30575" checksum="E6302BEF053EED8D" modified="2014-09-03" version="1">MNVACGYGTEGEPSSMYTLYQGMDVEEYLRSVREEEARLPEVVAVETTDTSRQSHGKTVEQFERLQKIAAESVENDCAFVMNNNELQFFKTMKDDVNAKMSHAESTEKCALAEYCTGILRSEGDAANVSSYLHNLQDAHWELLFRSPPPDVLKICERGVSFASVQEILHKLANFICGSKGKNIDEKSSRWLFSTLLILDDLHAVQESVSYELQRLKRALSRYIPTKMGDLNEYDPENDEDIAKRQIDEIIIAGHILNLCIIRQHFKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D292</accession>
    <name>A0A061D292_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0200280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767057.1">
        <property type="nucleotide sequence ID" value="XM_012911603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D292"/>
    <dbReference type="STRING" id="5866.A0A061D292"/>
    <dbReference type="GeneID" id="24563412"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200280"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="109" mass="12680" checksum="C08C200148BBDC78" modified="2014-09-03" version="1">MALFCPLCHSILYFTSKSQTSSCFACLRCSYELPVSRRFHKSTVYTQFEKEVPRSPHSANEFEHAPKIIAVCPSCHNKEAYFMSIQTRSADEPMTQFFVCTACRHRWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2K4</accession>
    <name>A0A061D2K4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767197.1">
        <property type="nucleotide sequence ID" value="XM_012911743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2K4"/>
    <dbReference type="GeneID" id="24563552"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201680"/>
    <dbReference type="OrthoDB" id="439046at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600542" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="174" mass="19290" checksum="D298F09DD17ACBCD" modified="2014-09-03" version="1">MVWDSLHNIALMLCLSFVKLLSKPGDFNTTLENSAVSTCGSVIGMDISLKKVLIVPQMKLRKGFGSRFRMGVFKLGSLAKENLKSLKRKISDLKEGVESSEENHQLADHHLKTLADKLYGLENVTGSDFTIQKIGKALQTKFRSQIQEPINTAIQQVESILGELGGNFRNLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2R0</accession>
    <name>A0A061D2R0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0106660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766543.1">
        <property type="nucleotide sequence ID" value="XM_012911089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2R0"/>
    <dbReference type="STRING" id="5866.A0A061D2R0"/>
    <dbReference type="GeneID" id="24562898"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106660"/>
    <dbReference type="OMA" id="SHNEAFF"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="5">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="259" mass="29067" checksum="7FEED5AFE3C53A2A" modified="2014-09-03" version="1">MSEKDELDILLSAAEGGDNIYVSTHDPKFNRSIANLNVKESIDMAHYLYVESGLYSSRRELSNNFKYQIPSHLVDSAATEGLKFKDNVCYDYLVALGCRGCNRSVDFKSPGMFFDGSAGNTMRRDLQCPRCGHTIAPIFSSSCTDDYVDSLRRSAAFGRGNEGEKAYMYGFRQGCEFDNSGKKWWNDFSRREGAAADEGSTLFMAKNANKSSREVVKQLCEKCGCEEAYYSTFQARSADEGMTVMYECKHCKNRTVVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D362</accession>
    <name>A0A061D362_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767234.1">
        <property type="nucleotide sequence ID" value="XM_012911780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D362"/>
    <dbReference type="STRING" id="5866.A0A061D362"/>
    <dbReference type="GeneID" id="24563589"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202050"/>
    <dbReference type="OMA" id="QMCCVGG"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="287" mass="31295" checksum="3331907A36C38421" modified="2014-09-03" version="1">MEGCGKASMRQRSTARPSHLEDHLDGSSAAIKVIVFGGMDGILSMFAVVSGCAGAAISPLQTICVTLGTMLASAFSMGYGEYVSCGAERDYVQSERMREEIEVAEKPDCEKREMFEIYVHRYHFSPRDAKNLVDLTFRNKAFFLRHMMVEELGILLTEDELSPAKRGLLMFGSFCILGSFPLLGFFGFFVAEAGSTLSHTIGFIATAVFSLLATMCLGYFKGSYMRQSKAASALKMTFNGVVVGLISYLSGVILMVSPRPAKSTCRSAFSPTRRCNSAHHCALIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3D9</accession>
    <name>A0A061D3D9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767432.1">
        <property type="nucleotide sequence ID" value="XM_012911978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3D9"/>
    <dbReference type="GeneID" id="24563787"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204040"/>
    <dbReference type="OMA" id="CYHAVHK"/>
    <dbReference type="OrthoDB" id="361706at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="1">
        <location>
            <begin position="101"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="466" mass="52131" checksum="23142C13509B2ADC" modified="2014-09-03" version="1">MATNIPAVATTLQRRSVGFIVRHGSAVGAKQIEKPSDVARYIGKVAKELGADERKKHVPQCAQLVDSMCRNITQYTAMEVRAVAHGMPIIFGADISSAWLQAIATFALKRAHMMPVYLLYPIVNSLCRMAKHERDVPVDQMLAVCRERVAEANSIDLATIAQTATLLKRSREILELMNAVADAATSETILEGISTTNAVLILYSFGQMGIRHKKLYQSMTQIITKMEHDDFQSHLIPIALHALAKFGNCDRNVLETIANHAIKVANNMQPENVSGTVCALAKLKFRHSLLLREMAKRTRELMSDMNLREMLCNRTGNILWGFAKLRHSDEDLIDEMIGGDRCAQYPRIDNMSFAQIFEALRCYHAVHKAYSNAAVVKALLPRYIEVMPQCSTQIVTQVAWCCCSLGCNDCGIIVQSLDVLKSRKRTKVEQKYVNMLLDALKHAPMEPEEILTHYEKELRTSGTDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3N8</accession>
    <name>A0A061D3N8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0203550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767384.1">
        <property type="nucleotide sequence ID" value="XM_012911930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3N8"/>
    <dbReference type="STRING" id="5866.A0A061D3N8"/>
    <dbReference type="GeneID" id="24563739"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203550"/>
    <dbReference type="OMA" id="EYHICIN"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="9">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="8">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="516" mass="57314" checksum="E11C5E1B7513F6A2" modified="2014-09-03" version="1">MAANIGARLHKDGIVANGIELVIRVNMSRRWVKGREEMGAIFADKTTQFAHVKVLTDSRNTDQCRNSLKLGSNVDMAIICTVTAVHAHSSKGGVVTIWTCSDLQDTALKVAIYGSIPGELNAVSQGSVIAVLNPDLNDSNRDYNYRSISIKHCDNVLLIGEVDGLRFCKGVTAKGAGCKNLVYTHHQGEFCKFHLKAAFAKPKPNKSTESANPADILKTVHERLETKHQEEAMGHFVFKPSEPAHPTAVLSKLAGLNSLVHKVTQNRMKTSAPAHVTVPVGSQPNKARPRDESINRTKEFEAAVRSLKSLMNSGQKESKKLLGVLQLIAKYIHYVDREVAKKSPLLKMCSELLEHPVDGVAIESLKLRREFRRMLHSPVKDNSTPTYLVGVRRPEDKQVATDRATDKDLDIIMSAASEVDAYVEKENVETMKRKLVTLERMDKAEEMKKTVTEIEITASYCHDCNAWTEYPNPVCKREGHHCASKKCKKEYHLCLEASCGYRYFSLNGQKPPSCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4A1</accession>
    <name>A0A061D4A1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0205610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767589.1">
        <property type="nucleotide sequence ID" value="XM_012912135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4A1"/>
    <dbReference type="STRING" id="5866.A0A061D4A1"/>
    <dbReference type="GeneID" id="24563944"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205610"/>
    <dbReference type="OMA" id="QRTEYNK"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="395" mass="44468" checksum="A4B6C8C535DD6E68" modified="2014-09-03" version="1">MSHRKFEKPRSGSLGFFPKKRCKSHRGKIRSFPKDDPSKPPHFTAFMGYKAGMTHVTYEPDKPGSKLHKKDTVEAVTIVETPPMIVVGLVGYIETPRGLRVLSTVWAGHLSDECRRRFYKNWYKSKKKAFTKYAKKYAETKMSKNVSRIVNYCTVVRAICHTQPSKTPLSVKKAHIIEIQINGGSIQEKVDYVTGMFEQPLPVNAVFSGNEMIDVLGVTKGHGMKGVISRFGVTRLPRKTHRGLRKVACIGSWHPARVQFQVPRSGQKGYFHRTERNKKIYRIGSGTNPRNASTDADLTEKQITPMGGFPHYGPVKEDFLMLKGCIVGTKKRPIVLRKTLTPQVSREALAEINLRFIDTSSKWGHGRFQTSGEKQKYYGPLKKTVTNTVAAAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4P4</accession>
    <name>A0A061D4P4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767729.1">
        <property type="nucleotide sequence ID" value="XM_012912275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4P4"/>
    <dbReference type="GeneID" id="24564084"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207010"/>
    <dbReference type="OMA" id="CTHELAC"/>
    <dbReference type="OrthoDB" id="10465528at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="17525" checksum="7347D99BB63CFEF0" modified="2014-09-03" version="1">MSVKTEINWYYRAILSSITPRNSPENNRALIEEIIEADFKLVKGALDLILSGSIAKVNFAPNQQPTSQSFYSILSKDKTRQYLVMQGYCDCFYFAEHVLSRATSFTCTHELACVLLEHMSADLQKDGDNFLHSVEELDEEEFLERMHLLYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4R2</accession>
    <name>A0A061D4R2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0102670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766125.1">
        <property type="nucleotide sequence ID" value="XM_012910671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4R2"/>
    <dbReference type="STRING" id="5866.A0A061D4R2"/>
    <dbReference type="GeneID" id="24562480"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102670"/>
    <dbReference type="OMA" id="MSKAQPP"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000023">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR93939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="80" mass="8991" checksum="AB26C066EFFF6CC3" modified="2014-09-03" version="1">MAGGSNAGPDLRRYMEKRLDVHLNGSRHVVGVLRGYDTFMNVVLDNALEINGDEQVKLGMIVIRGNSIVYWECLDKVNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4U0</accession>
    <name>A0A061D4U0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766155.1">
        <property type="nucleotide sequence ID" value="XM_012910701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4U0"/>
    <dbReference type="GeneID" id="24562510"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102920"/>
    <dbReference type="OMA" id="SHKRTIV"/>
    <dbReference type="OrthoDB" id="10473223at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="227" mass="25015" checksum="B9868ECB618D71AE" modified="2014-09-03" version="1">MTANKWTFCTDDAEFSLIHIKSADVLEGRLSHANSINSEHDAGDRTVLDDSWPRDAAKSVPIHVMQVESKDAWKSKYSALEVSVDIPHDEGDGGVAQSPRLDTLASDAISHKRTIVGSNTDHYVIHATMDTAALSNNMLGMSLPLIAYVNPKVDAGCQLTPFTLVGEVIVREILGIETALKDNLVLVTLTNRDVRQDVEVEDVLLSGAIYRKPERKRYERIHQNGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5B6</accession>
    <name>A0A061D5B6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ski-interacting protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0104680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766345.1">
        <property type="nucleotide sequence ID" value="XM_012910891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5B6"/>
    <dbReference type="STRING" id="5866.A0A061D5B6"/>
    <dbReference type="GeneID" id="24562700"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104680"/>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="4">
        <location>
            <begin position="135"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="447" mass="50400" checksum="0DF7FBAD8FE3B1F1" modified="2014-09-03" version="1">MSNYTRKSNHVLLQSQRELLPGSSGAAGCFSIQEELAVSRHDAESSRTLALQYDSEGRPEFDRVVRQGVRSDKIVYSKPADQREKQFSEDALARPTDDAVNKNLDRTREALEMTLTRRRQLGNASSGPTSEPVIFRYTPSQQSAGTINQRLIKMVEKETDPLEPSRYRNKKLPAAAPSPPPPLQHSPPRKLTKEDQLAWKIPPCISNWKNSKGYTIPIDKRVQADGRRLQEVYVNEKFAVFGESLSLAERTAREEVRLRNEAHRMEKLKEAQEKEEQLRALAARAREERSRIDVHSELQAAEFERKREIERELRLERAGKKIKAAAARDRDITERVALGQPAPSRVSDTHDSRLLNTAAGIDSGFNAGEDETYNVYDKPLFVDRSIVGIYQHSNERFKQSLGASEAARVPSFANAAQVQRTTPVEFVKETSDPFGLGALLDKANKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5I4</accession>
    <name>A0A061D5I4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767473.1">
        <property type="nucleotide sequence ID" value="XM_012912019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5I4"/>
    <dbReference type="GeneID" id="24563828"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204450"/>
    <dbReference type="OrthoDB" id="10440529at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="243" mass="25709" checksum="0B7A0DB579F15C67" modified="2014-09-03" version="1">MTAPTPGGSVLIAISPVEDSLDVQMLHEALVPLGGAVVTDPEIDLQPNLLRREVLAKIPAGSNPAVLSEYSVRKIDVSCKNTRVTATSASAEDHDSNASIRGGVHSSVSAVESPGSEGLIHDNDVKATLSENGHIESHIAPIEMTHSPPKLTAADGQMSYVEPVKPEPAADVATSPTTKAEPSNNEGANVACEWIPALKRELERVKRLKPLPGDTTVKHCSPQDLICFVLYAALLAALYPLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5P4</accession>
    <name>A0A061D5P4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766455.1">
        <property type="nucleotide sequence ID" value="XM_012911001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5P4"/>
    <dbReference type="GeneID" id="24562810"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105780"/>
    <dbReference type="OMA" id="WMPHCEA"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="264" mass="29327" checksum="76EAB19F2C70A5D1" modified="2014-09-03" version="1">MKGDDGDWIFVTGRPSRRRANVHIPRRGNLDESVWRCARDRVIREVHEAWKEAQKFLKIVLQTLHSHLGSQQTTRIVALGLGSPTALSLPLIRSCCCQLAVCLIVRETLNINRVDVFDPIMDVNDVEACRSLLHDFRVDLPGLQSLCESRHQIYQEDSGSAVSEPQLLLWMPHCEAALYRAVLLAIEAGADPLAAAKELCGAGGARSHMRYDLSNVVLVGNSLKDYGGDVAMPQHIIDRVVESALPVFDPFPQAFSGTYVTKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5W2</accession>
    <name>A0A061D5W2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768292.1">
        <property type="nucleotide sequence ID" value="XM_012912838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5W2"/>
    <dbReference type="STRING" id="5866.A0A061D5W2"/>
    <dbReference type="GeneID" id="24564647"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300110"/>
    <dbReference type="OMA" id="QFCNINT"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="595" mass="69740" checksum="F22CC6F4ECEA4256" modified="2014-09-03" version="1">MDRSGKVSRHSHSRRKPKVYGSEHHRMLNFKQFIMMKEDEISPEEAAEEYSKYFQEFLSSEIRRYYDMYEHLAFFREKFHPYYLHIDHEISKVDVLNSNRDFVLKYTNGHFEELLLEISFKRLYGGSSSDANTTPSEAPYKYSEWAYEIPVEYPKDDTHTKRLPIDSPLLSVLLVDVPDKVFKHEIQNALKPHLDRFSIYMAERDLVRTAFISVDECDLTKLSETLNGNRLTVQEFLLRFEPCNPLQERVRVRVCPPVCSHPIIVARDVEITGRVIRKLDGDFCGSETSFVDILPADIDIKKRLDLHLTYLRKVHSYCYYGRIRQKGKSYIDLWDLCGPGHVRVDLSSALYEKETGLTTNHVAVKYASWETGKKGKVPAEVPIRDWEKELTSSCDVSTSQLQWLRDVESFAEHLLGCDLSPPAYVQDEAEIEDKWKQFCNINTLVDGPERFRCNLCHKLFNDSKFVWKHLKLKHSDCYDKIVIECGVPQMKEIFTGSHKAARCNPFERLLSVPVVQPLPDDVDAPSVEPNGLSDSRNSMRADFNNKRRRRDYFDFDRPQAKRVRFLRLICYWLQEHTMFFAQDDYSRPSVKYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D635</accession>
    <name>A0A061D635_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spp2/MOS2 G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0206350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767663.1">
        <property type="nucleotide sequence ID" value="XM_012912209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D635"/>
    <dbReference type="GeneID" id="24564018"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206350"/>
    <dbReference type="OMA" id="NKPKEYK"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="4">
        <location>
            <begin position="259"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="455" mass="49401" checksum="C07FC91C7D6E0FC1" modified="2014-09-03" version="1">MKISFGLSSAAAKPADAGRVAKPAASKFFEAVPETKQAVKRVKVTEMENGLLRTTHDADGGYGTLESGASDGLCVIPCTNRLDDVAARTDEPQHTAKKAPIEIKYGLNLMCPVKKGLQKATDAAQVAEIEAATVVGNANDTNRMNQFCQQPRSERGNETSEASRQSNVVENSNEAEANTSATQATQRHMAPQQAPAPIATPSTDADVAKLILADVEQQKLREKLFGTDLVEQAAKTTPILLRGKNKKRQLQTDPEASDASDHEPAYEKVAVDQFGLAMLLGMGFDPKKNTNKPKEYKRRVYERAGLGADASMKQNMEALTDTRVMAKLKKDQMYHQSHSPHAGSTWVLPGLQVRVVQRDHANFGKKGVVGKVNGVEAILDVGGLPVTVPAAYLETVVAQGATRCKVVRQIARHNEKFYVPIGTVVDVETVTKTYAKVRFRGQTFTVSLDDICEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D646</accession>
    <name>A0A061D646_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0107030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766580.1">
        <property type="nucleotide sequence ID" value="XM_012911126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D646"/>
    <dbReference type="STRING" id="5866.A0A061D646"/>
    <dbReference type="GeneID" id="24562935"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107030"/>
    <dbReference type="OMA" id="QYDPPQQ"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="102"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="320"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="707" mass="78207" checksum="37F3E429A44BAB0E" modified="2014-09-03" version="1">MRLTQGHSRYNLALCRRLSQFYGEINDEQPSQVQPNDKSREAAAIRRSAAVAPNRDDAVSLGDPSLFSGSYSDLSSTLSDRVIRSLSSCGFVQMTVIQSRSIPRILDGCDVLIRSATGSGKTLTFLVPALQRLVCPRNGAKITRQDGTCVMMICPTRELSVQTKDTFSKLARPFPWIVVAALKGGDSRKSEKAQIRKGITVVIGTPGRVLDHCESTASFKVSNMDMFVLDEADRLLDMGFEVKIRGIYKFLMSSRDVESAGKLQTVMTSATLTDAVHKLADFCLRTNRETIGVDDDFLAMPSTLTHEYVVVECKDKLICLISLLLKYVSNGEKVLIFVANCQTVVYFHRLLQSLTWPTVAGAKKGKRDLPSKVAKKLDSYSNTIDEYELMTGEDARQFKGPIEGRPKGLPVFGQVPIHMLHGSMEANDRAGYMSDFMSQERTIMVSTDVASRGLNLSKVDRVIQYDPPQQLEEYIHRSGRTARLGGKGNAILLLMPHEVHFIQALRQRGIHVKQVMEGLVWSYIEQTFVPKHLRSFKGYNISFLRNCFSDLVSDDPELLSHAQNAFRAAVQSYKSYARELRRTFDFKKLHLGHYAAAYCLKQRPGDLLPDRRQSAAPGTAAAGHSAAKGKGANARAGGKTHTPKPAPTRVNKGMGRVSQTTRTIKKVSKPSKPPARTAKTAPLSSAASQAALKAIEYLKSRNEVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D675</accession>
    <name>A0A061D675_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768382.1">
        <property type="nucleotide sequence ID" value="XM_012912928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D675"/>
    <dbReference type="GeneID" id="24564737"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301010"/>
    <dbReference type="OrthoDB" id="361887at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="208" mass="23020" checksum="581E16DF5A151BB1" modified="2014-09-03" version="1">MAYDRDLTAASGEKATPSTEREWRLFERQYGRWLKDNAYTISADEGKLFKNATYSCFGMGLCGGIVTSFALKKSNVISRVATRRVLSAFVALYSTAICINRKRRSVYTELLNSPGRLGNAARHILIETQGHLATSSETTTHADDTFSDKVSVSERIGDYETPGKLYANRMAVSDPHANDENLNKAFVMTARKSPIADMGRGTKGEFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6I4</accession>
    <name>A0A061D6I4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767813.1">
        <property type="nucleotide sequence ID" value="XM_012912359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6I4"/>
    <dbReference type="GeneID" id="24564168"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207820"/>
    <dbReference type="OMA" id="EYRYKYW"/>
    <dbReference type="OrthoDB" id="333370at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="492" mass="55809" checksum="E69A4BC91F210BA9" modified="2014-09-03" version="1">MGHDRSAYSSGTGQQSCSYFGDDDSYNGASTGLTQGYAAHTAGYKRGFTLHLSVRKLRKMKRRQINRMNKDLELFRRVKERRLKNPNRLVDIRKINFINDKCNPALMRLPVSPLVDLNGLVPFKTVPQMTSQVPFNPAPMLHNVGFRFKPDRNGKYERFCEPYPMDEILQVVDARSLGAISRMAGKYKITGEGTKIPTPMDSQIVAPGASVGKGYGFGLTKKSEPKNKPIPLSNFKPFEPNAETLVESPQELESVQMQARAYAESLIGKIAEPSSVEAPSAAETSPESPGDSAFAAETRHDRARYESDIGTISQHGATSGRYDNVKDAVGVSYMDDVCNEGDIMRNPRYLGEYRYKYWYHPFYGNATMPGDEKRLIEEYNREHPDEPLEYEEYKVDLIYCHSNGTIVYLGEDQDPYTNQADDFVMEGEDPREPRFVVQAEAGFIKEHQLKLGQILPNVNSEMRERYYDNIFFTPKSVRRQWQVHLPDGTPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Q7</accession>
    <name>A0A061D6Q7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0208510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767883.1">
        <property type="nucleotide sequence ID" value="XM_012912429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Q7"/>
    <dbReference type="STRING" id="5866.A0A061D6Q7"/>
    <dbReference type="GeneID" id="24564238"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208510"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="21518" checksum="ED2CC0090B7AA07D" modified="2014-09-03" version="1">MKTRLSSDILKIPDGVTVDVRSRKVTVKGKYGDLTRDFSHVPIEIRLSKDRKTVILMQWFGTKSMIATIRTVMTHINNMITGVTKKYQYKMRLVHAHFPINSNIADDGKSIEIRNFLGEKRVRIVKVLPGVKIEKSDAVKDEIILTGVDVESVGRSAALIHQCALVRNKDIRQFLDGIYVSEKGLVDQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6U2</accession>
    <name>A0A061D6U2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0109520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766840.1">
        <property type="nucleotide sequence ID" value="XM_012911386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6U2"/>
    <dbReference type="GeneID" id="24563195"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109520"/>
    <dbReference type="OMA" id="NSPNWFA"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="18"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="462" mass="49806" checksum="BF0C82F25400AAA2" modified="2014-09-03" version="1">MVKEITSETKLVSYGIVGKILYHALSFMDGYDLQMLSVCMRAFEITLGLSPSSLAIMATVETVALVACCPIWGYLVDAYRIGYVLGTAMALSGISTMLMGCVSNFGVILALRVIHGCAMGCTPPTTQKLITLSTDEKSHAAAFGLLHCVACLGRLISAVLVTYVAGFKIMGYPGWRPCYLGLGLVWLTMSAITVFFLKPVNGQDCPVSMEERSSIKDTLRAIFQTATCKLLLLVVFISDAPFCAFAYIILFLQYSGVTDMKAGITCGLTLIGGCIGGGFGGFIVDWCHKKSNDYGRLHAANVIMVIRLVACIALFMGPAPDGDVSWYHIVELMTLGASLMTVSSIDRPILASVVQKKYQASATGLIRCIAGVLSTIFFLPLCGFLAEKAFGYKPSTEPIATMLRETRVNNGDALRKSIMYILLTGTIANALCYAAFFFTYPHDAKANERADESLVSETSDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D735</accession>
    <name>A0A061D735_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768712.1">
        <property type="nucleotide sequence ID" value="XM_012913258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D735"/>
    <dbReference type="STRING" id="5866.A0A061D735"/>
    <dbReference type="GeneID" id="24565067"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304300"/>
    <dbReference type="OMA" id="WGPGFEW"/>
    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22145" checksum="4CD79C6B2A646664" modified="2014-09-03" version="1">MVTECLGSCYEKLPQPELVLSPEDSELNYYLWMPGVQYQPRLQKKLSELRSITADSDVMQVDEVIEEVIAKDELVVKFEGAATNGVMDLGTAANFVRELGASPSQAELLEYSATNGNSLTFDNIKELLAVGMNQHENAAYLESILMSLSRDKNTINREHFEYIMANYGEPLTAEELAAVRNMFFSSGDDISCGELAAQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D743</accession>
    <name>A0A061D743_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RTR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0110370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766925.1">
        <property type="nucleotide sequence ID" value="XM_012911471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D743"/>
    <dbReference type="GeneID" id="24563280"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110370"/>
    <dbReference type="OMA" id="NPCEPCK"/>
    <dbReference type="OrthoDB" id="361971at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTR1-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="468" mass="51499" checksum="C0930A7F6CD8E22F" modified="2014-09-03" version="1">MTGEGGGRPAEDQLGGPTCQLSPDQVADQLDNVSLQRGPERVSNSSLFQRFLEQLSLQCSSGLRFNCEASGECCAPCSVVRRHIATYVDVAMLEEIAMSRRQADLCGYLYCNRSVANRGRHARNESTYKIDLAARQVYPRKVYESFCSAACIEKNASVEAAAAKSPMETGVITPRAVRNSSPKSLHALLSGLRRLQPCAGVAAPSTQPHTTWVPLLYRTREPEQVKDKCVMFNYKPLAEAKRVHFDLPDPPAEQSATPQLAGVGSWLGENDRPRKGSVARGQAAGAADTDSRRAGLTSPAEESAFDYSGLYDPSEAVSPRAPLLKCLNLFSILWYTLSTCLTYRTREYLRSGALTGCSLDDKTRLWYATLLRHLPEDMVPTVSKEFESMLSTFRIGNNTPVLSEDLYRVLAYVLLYALLRNRGQVLAAGPGSAPIDSYLRDVEAYLVETCNLDVDSIQILNEMLTECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D765</accession>
    <name>A0A061D765_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ham1 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768559.1">
        <property type="nucleotide sequence ID" value="XM_012913105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D765"/>
    <dbReference type="STRING" id="5866.A0A061D765"/>
    <dbReference type="GeneID" id="24564914"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302770"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="27621" checksum="A6789FF57D6BBAC2" modified="2014-09-03" version="1">MEKIRINACTTNMNKFKELSAILGDQFELVQRPIERKSNTHDDCMIGAVTETQGKPREIVERKAKEAYAMLNEPLFVEDVSLFFNAFNGLPGPYVKDFLTSMGPQGMYRMLADFEVSDRAATGSQLMQDKSATALCSICFIDGNTLETFEGRAENRGAPAGLDGTLRIQHQQLMAFMASPANQILIGVQGWHFRAQTNGQDVRRDDGRGEKQHLKPVQGSQQIEGNTPLTYCHMLQEFLVKYYTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7A2</accession>
    <name>A0A061D7A2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768033.1">
        <property type="nucleotide sequence ID" value="XM_012912579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7A2"/>
    <dbReference type="GeneID" id="24564388"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210000"/>
    <dbReference type="OMA" id="SEMTRCK"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="390"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="578" mass="65775" checksum="FADF15AB83883D1B" modified="2014-09-03" version="1">MANSQLEGICRNLKVALEDTDALYRSVQSGSGVTPRSSKVPNKRVVHFGQSRNPTREYNPPLTVPQTSPSRRRGATSHPSKPNIYADYGEETTKVEKDIQYVTKATHSEFFRALNVNLDGWTEAQRQVFYNLVTSAEKHMHLESERLQREYSSQLDAKLELARREMAEAQGAVAAELSELRVERERRAFDDVEDRRRTKLMQDALHNLQKSYDNLMDECTAKSNEIVRLNSAMAVTDRAMLGLKQRVLELEGELNERLQQIENLHHEVANAYKQMEAVSGNNAKSERDLAYTRNELKQARDQVTTLQLEVESLNLSMQLASTEKAAMESKVRALENEVSELGAERHKLELTVSTLESSTVPSLKEQCKLLEEQRNLARVETATCDKRHELAQAKRELESMQYKCDQLSEDNRVLLRENATLSKQLQELKKKTKECENDLFQMKCQAHLMRQKGYSVRTAGARADSGSGGAVGAELPEEETADATPNRAQPARRDIFAPTMFDGPDEETQEQIDTLEKELTELHLEKDRMISEMTRCHVGPKSPANERRRHLLLERGVAETNQKIHELSESIRKLYTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7F4</accession>
    <name>A0A061D7F4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768827.1">
        <property type="nucleotide sequence ID" value="XM_012913373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7F4"/>
    <dbReference type="GeneID" id="24565182"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305440"/>
    <dbReference type="OMA" id="EKNKSFC"/>
    <dbReference type="OrthoDB" id="363892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46778" checksum="5967C1BAC9618B59" modified="2014-09-03" version="1">MGDTPLDAAATNLSQELKPVEIAACEADDTVVGEDEGYELEELKEVVQNILWDIVDTRRPLLRRLINAKTILEAPPPPPPKQGARKPKVPEVDGHALFEEVVKEILEIDEELGNLDREILDEQLFILCDNPPPVPPSEIQIILFRKNEQVTMFEHHEIMSRLFSFLDVQSLLEFSEASKLCREAVDTYARKAAYNLLLHRGSVCSNLSYWRQVIEFFFTEVVTLQPISRSNYQPIQAQLRMNKNVFPINTQSMKAHTHVSFDFIKPHYIVYCDHQRPMAHTCEASRALDCDRKAVTKVITANEFIVEYCKRLEVQDPDTPAWGVPASMVTPAYVALMLKVTLDTIAQCITKHSGLVEYRRTEYTANATHHITHRIWLQLSLKWDFRFGDDAQNSLYLNVFDHFRWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7G0</accession>
    <name>A0A061D7G0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768832.1">
        <property type="nucleotide sequence ID" value="XM_012913378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7G0"/>
    <dbReference type="GeneID" id="24565187"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305490"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="12263" checksum="E5D1D9C8766BF99B" modified="2014-09-03" version="1">MSRAPKAEQFEMSLVRLKSGAGSRADDYIEPEDVDAEMPDEVVEQKQDDSGAEEATEKPRPKVRITSKEWRNLNKVNYGFNKEELKQFIRDIKQFKPVHGLRLPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7L2</accession>
    <name>A0A061D7L2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768719.1">
        <property type="nucleotide sequence ID" value="XM_012913265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7L2"/>
    <dbReference type="GeneID" id="24565074"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304370"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="10274" checksum="93F9DE8AF6F1EB39" modified="2014-09-03" version="1">MEHKNSQIQHRTCLKNDNLRCFRAYLNVHVFKIRHEASSKLPIVTTLKMLSKMLKMFHSRLDLKTRPTNRDRIWYSISNHKIGPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7V4</accession>
    <name>A0A061D7V4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767180.1">
        <property type="nucleotide sequence ID" value="XM_012911726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7V4"/>
    <dbReference type="GeneID" id="24563535"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201510"/>
    <dbReference type="OMA" id="GYAVYPN"/>
    <dbReference type="OrthoDB" id="365894at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596067" evidence="2">
        <location>
            <begin position="23"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="331" mass="35233" checksum="658CAF081A84CD9E" modified="2014-09-03" version="1">MCGVTRLVTALFAFLAPGRSAALHSLVSPVSFFGYSHKSVPVVGVVRELAVVGAATNTAELRCPAQLTVRVHKAVLRDSTSENGLATENGTRDGSSDGAGTSDCSEFFHNKCMNLTSCSVSVSECQAASHAKSGAYRVALSYSTPGPLYDGSLFSEGVLQRFLMVPDVNAGEVSSQANVGSGHFKRVLRRCLESEQCKYVTCDDATLHDDQYVDGRPAGRCALLKPESFRLPGYAVYPNYAGLCSRPSYVKTRDFYEVAKTARSHTHSSFTIAYKPTSQLGVNPRYAGWVCRGGPTIVPMAGHVVAVPAARGRGPTRAAAQPGTSMSYNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7W9</accession>
    <name>A0A061D7W9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767200.1">
        <property type="nucleotide sequence ID" value="XM_012911746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7W9"/>
    <dbReference type="GeneID" id="24563555"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201710"/>
    <dbReference type="OrthoDB" id="366379at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1151" mass="123578" checksum="BF4D3C06755A9ADA" modified="2014-09-03" version="1">MAGFGTIDSRFSVSSISQFYSSGSDIDDDDEDDDYSPMHLGATESRYTAEREDAPKPSATEETQAVYTPSKAESVASDLSSPVGVSQSAAGTHAENPAGPGSTPPYREEYTSPVVSESDAESVRSSVAGFGSRAAASVGSAAGEDRAPERLGEEEEERASVRSSLSEASRRASVEGIRPPSAFRESGGTSSRGSEVQGSVHGSAASSGDEVEKATHDESEPERNAAHSEHSRDGSSAEKHVATLSSLKREVVDEFIQQNPSYNVFEDKSVFPASTLNQTNEVSAGSVKSGHLASVSSRSDIPSVRSRTSYPRGSASSLAGEREVPGVARGAADTADGLDVVSGVEHSTAISVNGEYDLPGAVTTVMESQYRGPSDGFGAHEIPRNAQMDIEYESDSASGEESPLRGSSEAEIMEEVERERQVDTSLAPSDAEHGSSSPPSPPQNLRYAADIKRAHKMEERVQASDGEAERSPAVSPVSDRASTPNSPNSPNFFIDIGDHYRDSVDNPNLLSADATPMNAGEAFSPQQTAEDNNGTGYVSPSYQSAGRHVVHSGTLDDAAAGRAGHRSSAATVVVVESAVGSNPMLGSATAQHPQDEHHLAKALSNEVAYYKQLYAQLESKVTEIWNQREAFRVAGDRMAENIVRHSGVKAVRFEGQTNVESDEDIANSSRDIYVVGSASARTPVSQQRPLRSNSSVHAREVLDPSGASLDCFSLSPRGIRCDRGTMERLLNCGAKLYAFKLSTPGVRSKDPLFIDVCPLSSAYSGKIVLSNDVGLFKVSLTKPSAESQGSMSYLMMNYLGLRPEQCSSGYLYGLLNSFADYVGLPWSTGTDAEDSQSHRAGSGSATARKPQSDDSPPHVHIKYMHSLVTTAQGLIIPEDSFPSNCNIGSMFHGRHEHLFCVEQTRGLKKSDLQDNGNFTFILDTSPSTSSRRSGARRFNSHVHIVHSVTHEYLCVDLLTRELRFAGGQCSRAYSKYVVPASFKMVPLYNVLIDRAAGEQEKVVEAAASARYRRCVTERATSRHSYDMPRVSRHMVDEYGNFAPHTQAAGTPAPSPSNSTPSSSEDPTPKGCVLHATYPGNMKERAADTYDIRDSGERASDARNVEAMYSLLGTTDHLPSRQDQSSALPPRRGPVVKDLRMKFERLSSRNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7X2</accession>
    <name>A0A061D7X2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 70, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0306850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768967.1">
        <property type="nucleotide sequence ID" value="XM_012913513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7X2"/>
    <dbReference type="STRING" id="5866.A0A061D7X2"/>
    <dbReference type="GeneID" id="24565322"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306850"/>
    <dbReference type="OMA" id="DSKPCIE"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595881" evidence="6">
        <location>
            <begin position="28"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="666" mass="73157" checksum="71CC0175F77DF384" modified="2014-09-03" version="1">MFAKNFVTAAVAVAAGLVLAHSRVAVADPASGKGKRGRDVSSHRAVEGPIIGIDLGTTYSCVGIYKNGRVEIITNEMGNRITPSYVSFVDDMTKVGEAAKSDATINYTNTIFDVKRLIGRKFNDKEVQNDMKLLPYTIVNKSGRPYIQIKDSNKTKDYAPEEISAMVLKKMKQIAENYLGKEVHKAIITVPAYFNDAQRQSTKDAGAIAGLEVVRIINEPTAAAIAYGIDRATVESNILVYDLGGGTFDVSVLMLDSGVFEVIGTAGDTHLGGEDFDRRVMDHFIKIFKKKHGVDIMQDKQAVQKLRKEVEAAKRTLSSTTETTIEIENLIDGIDFSETLTRAKFESLNEDLFVKTLDTVKDVLKTIQMSKSEIQKVVLIGGSTRIPKIRKMIEEFFGKEPDYGINPDEAVAYGAAMQGGVLSGESTHDVLLLDVCPLSLGIETVGGVMSVIIERNSLLPAHKSQIFSTSSDNQTTVTIQVYQGQRTMTKDNTHLGKFDLTGIPPAPRGVPQIEVTFDVDTNGILSVSAEEKGSGKKRNIVITPDKGRLSPEEIERMIKDAEANAEKDKEIFEKVQSRQALEVYLDSMKKTVQDKDKLGQKIEEDDKDIILKAIAEAETWILQHPDADAEENTDKQREVEAVCNPIISKLYSSGEQADDSGYSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Y5</accession>
    <name>A0A061D7Y5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767220.1">
        <property type="nucleotide sequence ID" value="XM_012911766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Y5"/>
    <dbReference type="GeneID" id="24563575"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201910"/>
    <dbReference type="OrthoDB" id="10388223at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="331" mass="36326" checksum="B2FA42633082B25B" modified="2014-09-03" version="1">MVYNSLTDAPHNLKEGIDWLIALKGTNAESNFKAMAAAVHKFLADKPVGKMDVPALNKIKSIFKKFIGQSALNKHSFVRRLLGRFERKMSTKVSLFHKRFGSLDPSDCENVIEATGVKPEHIAVELAKAVDGCEKFLGNIKASDHYESAYSSRATWDSSCSRNPEACAVVLVGIAPILYTGLRSLKEASANVANRQWLVSYTEMHLKNVMKAVGYKTDECRSGISGLDIFKTLRNVKYDILNSIYSLAGFWAFYGFDKMGDLVVEITKDRKAVPAVDGKGKQPVIPEAEPSVDPVKPEVGEVEQPVKVAKAAKVAKSGRSGKKTTKVSQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D803</accession>
    <name>A0A061D803_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Las1-like family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766021.1">
        <property type="nucleotide sequence ID" value="XM_012910567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D803"/>
    <dbReference type="STRING" id="5866.A0A061D803"/>
    <dbReference type="GeneID" id="24562376"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101640"/>
    <dbReference type="OMA" id="FVECFFC"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="631" mass="71316" checksum="A2F64674571746FC" modified="2014-09-03" version="1">MVLEPTGWYSYDEFAYVFSRLRHPEEYASIATKIAVWKSRAKVPAAVTATESLISAVVADHQCSLSESGLRSLYAMAVIRAVNLLLDHEQDREYARSLRVLAKECELPEYIITVRNECSHREIPDLNTLRLAAFDAINYVYNKYWSAQHKSIVFKLSNPEYDALCMSSLLIGCYSSALTKLPLDAADPCVLWAGYRGGGSEARLALCRRDHVFDSAVITARRLVTIATRRSYLSMWRRIHWKYKAVDHAHSWEARSLYQSVIVKTAGTARRLADGCAHQTFFVSAFVEFVFAHFEPDANSVFIVFMLEFLDHLPFNFAIELAAAALCIVFDLPDGLTDEQNRKQRPMYFDRIAQYSKFLSSTAATSVRSVQSGASRALEQESAEPGSARRRVNAWLISMLSWANMFEHKRYCHRLPMCIRTLACGVTADAQRLWVACGNGLARFAAATHALLPNVAVQLSYRGTLLPAGLRWNPQPWESDRLSHALGMLAWISGFLENGLIKKYVFSSLSTSEVQKRLKSLKGERKVHVTTVDRMLLPGTLWDPVRWRIQHTVRRLGESHACHSRVLSALDEASERCPVLLPSKISRRFQRSARRSTKPSAGNHHGIRALMQIYGQLAAPIKSLAHRERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D836</accession>
    <name>A0A061D836_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768889.1">
        <property type="nucleotide sequence ID" value="XM_012913435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D836"/>
    <dbReference type="GeneID" id="24565244"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306070"/>
    <dbReference type="OMA" id="DPCCNIN"/>
    <dbReference type="OrthoDB" id="364466at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="199" mass="22722" checksum="506ED337CF1348F8" modified="2014-09-03" version="1">MDGRSRTGYTTCLMAPNQGYTSGYNAYGANCVTTIPKQQDGYVIPADYRFSEGYSMDYYNFNKGGALQSTLECDPALYKDFQYPVADNSGYTYPAPEQMYRDYPYTGEEYNRYMEVLGTEQVPQVRYGESELKTIQLVNDAPQLTTEFFASNAAFQRIPLYPSRTVFRRRRQGDPINEWSNAFINEEDDLCDATQCCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D849</accession>
    <name>A0A061D849_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768899.1">
        <property type="nucleotide sequence ID" value="XM_012913445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D849"/>
    <dbReference type="GeneID" id="24565254"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="199" mass="21132" checksum="BE8CE3386EFE893E" modified="2014-09-03" version="1">MAVGRFVEADRSSVALAEVEGTGGGAGRWGAGGGLYGTVKRVPGVSTDVEELKSVIAVPGVVNNVRVEDAMIPFVCKPSICDVQCKGKEKTCECECCQRKCRNQEAQVCKLPDPSTALQSQSDSQALSSGHPTDENDADGSDTEDSSGHPPPYPAIAAVVVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D887</accession>
    <name>A0A061D887_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted ATPase of the ABC class, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0306470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768929.1">
        <property type="nucleotide sequence ID" value="XM_012913475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D887"/>
    <dbReference type="GeneID" id="24565284"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306470"/>
    <dbReference type="OMA" id="QTIHQSQ"/>
    <dbReference type="OrthoDB" id="189459at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046834">
        <property type="entry name" value="ABC_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046833">
        <property type="entry name" value="ABC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049069">
        <property type="entry name" value="MRB1590-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20446">
        <property type="entry name" value="ABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21117">
        <property type="entry name" value="MRB1590_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase of the ABC class N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase of the ABC class C-terminal" evidence="2">
        <location>
            <begin position="236"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="MRB1590-like C-terminal" evidence="4">
        <location>
            <begin position="540"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="669" mass="74225" checksum="86C0BD986681BF8F" modified="2014-09-03" version="1">MDRKRGLGPSASRRWGRRLDEERKHNYGNVRGNEEVGGCNPEYKFAESYFDEEDGVLQWPPEQMQIHTSNLINYLKGKDGGPYGSYKNLQGQWSVMENTVTVIFDRIQSDPFAPPSNIRIRLPSAVHRFPSDVISPRLRNVAACDAIARRVCVELKRLDEAENGRFRRTGFEMTKPRQYVLPRKSVVLTDEHLEIRMYVHMPGNGRRVNGYQAAHMFADVLPALVRDALHFGAYDSKRFYDHIKSVEDQEYLRAQLSELGLVAFVADGSILPRESGISDKPMTADAVLPFKSPDSLQVAVTLPNRGRVVGMGLKRGVTLVVGGGYHGKTTLLEALQVGCYNKVPGDGREFVVTSPNAVKVRAEDGRSVSGVDISTFIGTLPNGKDCRVFSTPDASGSTSQAAAIMESVEMGADLLLLDEDISAANFMYRDNLMDALVCKGSEPITTFLLLVQAFYKKLGVSTIMVSGSCGLFMDQADTVIQMNQYTCQDQTQAARDVASRYKVDLREPIAAAVSGNDIFETSQLNGRVVSPHTFKREQQKVRQHGMGSIQYGTENIDLGLLEQLVEPGQTSTITNIIIHLENMFRENRSAVHNKTLRELLELLYSKWSTSKAVGYNGLDDVNGFRPFPAGDCSMPRIFEVAAALNRMRSLSISGFKKAGYQPQSYSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8E9</accession>
    <name>A0A061D8E9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769162.1">
        <property type="nucleotide sequence ID" value="XM_012913708.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8E9"/>
    <dbReference type="GeneID" id="24565517"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308790"/>
    <dbReference type="OrthoDB" id="365890at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1588"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1661" mass="182129" checksum="28F41E1D8D46C8ED" modified="2014-09-03" version="1">MAAKSAAGATAHGVPLGTLKECLQFLEWLNSRQGGSMQRLVSGKLATRIGLYYNNPTFNIQFELSISNFLRHSSLLYKQISRSASPGNFGSKSANDITAAFSECLSKVHSAFSYLRHNVDYIYGSVGGGRLAKFQLNQSGDNELKTYLTANDDLYNGIISGGFDEGELNNIKGELLVHNLMNALERQTITPDVFTSVLFNNLEKDDWHKQDAGNVLLLLWAFCEYVETHEEGGDLKNNLQAELQKKGMCFDWGRLVAHCKVQKQFLDKLFGNTDDFSTKPFTTTGRAFTPDALKPEAFAGAFEKWFENHWDDIGEALEEIKMGVEDLEESTADFSPESLYPYGIVLNNREKHTWRDGLKNLPGVLNALVDSGDKGLATLKDILGGEQCPKLELQSPQSSPKAATPPVATPAAAKPVATKTEATKPVINKAGLSPNQNNGQSERNPATSSDATSPQTPSSTAKQAPAPAGTKGEKGLQGSSRTEPTKSPGINPVQKQTPSQPQPVAPPPAPAPGPPAGPGSPSQPGDGSGSQNGGGSTGQEPAASSHPAKPPTTSVQPVGSQSSGASGTGSGPGPVDQGSASEPAHESVHEASKRPVGDTAAPTGTPSGSGGGGNTYGCSKPITLPAEFGGGKYCPRNGNYNQYDKYYKTWSNTPTTLSNSVPNQDSSTQHNRNSDTSSSNHRTQHPLEHSTRSRPHSQADDSLQSYIFAEGNAVEAQNSDLTFPNIQLDKLPSLDGHEQLDHSYLKSQLDEEQKGQELEDQWNKYYADQEQIKTLDKMKHDMELQRAKIDELQHAKAVYSHQENVMHRTPYSLATNQMLSGTPINSDGISVVPPTSSKHQSPFITSKARSIPTVDLEDHSYSEYLYASGDDIKAAPDPFTYYYGGLAGHVVPDDSDVIRQRTFIAKSLEASKQVFDERRTKLMAMDKKVQRAKYFGGGEVDIKIANRTPELFFDIETAPKPTVNVTSDPLFQTVNPVKSAHNNMSMANEVHDDNFEITTVERFNDDDHEKGFKPMDLSFEIQNTDPFESNGVPPIPPEVLVERADRDTTQNENDPNYLDLQIGVPDRTLQDSSYDIDVDDPPPPPAIQPLEPVYPSTTAISVDFPPIDPPESLPNRYVDPYTHDAQTVGMCIAPWMKQTAIEDSTDIPETGLFPSQAPRTVRDMLQWLAGLKNEKHHSTLRQCIDKAFGGPHSDPSQLAIPVNGSHIRPGDVFDILQLTAMFAGSVLSAIAPNWKANVSSRSVKSKSSEEPDCCALLCQLRDYVYACHHQLEFLKAQCKRDKLSGGWQNCNYGSEVSPTNSPLHAFLTDGWDCDFKTHPFDPCNLCLKSRIRMGFRMEDLPNKSQSGSTLSTILTPSCGGSDPLLTLSSYLNCLTRRTPRTTGELVSFFHNFGIELHGYASESLSPLGTAITKSHTDCPEWDCLGDSDLGTVRGIRGSESLISKHNSKHDIDHPRTLSTLVGCGSDPDNCHPHCSPITYRAYALYSQRFAHTYLSWTVYLPDRLRESLEKLHHDLKKHDYAKCSSLYLCSTALPLLYLHGFTPPEVGPQTSITCLDVIGRLKEIVNGKPIADLISAMDDFLYNIREPFIYTIVALWSTALLIFANTMLYRLDVLHIRSHLIRTKASHVIDVKALLTKGRNMLSLYKDVDYFDEDPIGQLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M0</accession>
    <name>A0A061D8M0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0307720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769054.1">
        <property type="nucleotide sequence ID" value="XM_012913600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M0"/>
    <dbReference type="STRING" id="5866.A0A061D8M0"/>
    <dbReference type="GeneID" id="24565409"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307720"/>
    <dbReference type="OMA" id="FLANAPW"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="9">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="28229" checksum="6333DCB2CAF146E3" modified="2014-09-03" version="1">MSDSARANIRLPGKLFVFEGIDRSGKTTQLKLLSQKLTSEGISHRLLKFPCVDTKCGKVLVEHLASRDAVRSRRAIHLLFSANRWEMMKEVVSTLESGTHILMDRYAFSGVAYSVGAENLSYEWCIWPDDGLVSPDLVIYLDNPATVSASRSNFGKAPTQPSAHAAQGEERYEEVCKLEAVRRVYDQFRVLPFWQCFDATQSKEDLSNEIYEAIAPVLRSEPRRLSDTDLHLPRDVTLTSNGSVHLLPPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D964</accession>
    <name>A0A061D964_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766446.1">
        <property type="nucleotide sequence ID" value="XM_012910992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D964"/>
    <dbReference type="GeneID" id="24562801"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105690"/>
    <dbReference type="OMA" id="SYKCIYR"/>
    <dbReference type="OrthoDB" id="365245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="448" mass="49753" checksum="CF91CB468CFAE60E" modified="2014-09-03" version="1">MGACQSRDEQEVAVTTPKRGGATNVCDERLEDRLLTIPEISYGPFNRVALEWDTLGQLIPYNPESIRSATSAQSGDAVSEAHQVRKQLTSIKQPANLAKGDDNAASTNMQRFNSRGVTDDKQSLDQFRRAIVMWTNFKTSTNAVKKLHGVTDAWSYLDAENVPLPQEMFGSDGSESINELQGSEVSVGSALTQEDGPDGAMPDLCESGDGHVPIVTTEENVHLPFQDLRQSLNDLTQQPSSFVTHPASPMESDAPMENIDDAIDWLNYELVLRPYSSKDTARHSYKCIYRPRREFSPRDRVYRLDSNLLQLLGDILDPFQSHNEDQDRLSVGPKVKLLLNQLVSVKEWGSSTIQDNANSVQGVVTRKTKRVMRRPFDLRALSTISDSGDVQSPCAHPFYCLEDSGCDAGSGAYRDIHGTKENKHSINSTGNYRPHGRYGDMSDIPLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A6</accession>
    <name>A0A061D9A6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767685.1">
        <property type="nucleotide sequence ID" value="XM_012912231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A6"/>
    <dbReference type="STRING" id="5866.A0A061D9A6"/>
    <dbReference type="GeneID" id="24564040"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206570"/>
    <dbReference type="OMA" id="TEWVFNS"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053264">
        <property type="entry name" value="Lipoate-ligase_2_inactive"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43506">
        <property type="entry name" value="BIOTIN/LIPOATE A/B PROTEIN LIGASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43506:SF1">
        <property type="entry name" value="BPL_LPL CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="314" mass="35263" checksum="5969E0A4C51C9909" modified="2014-09-03" version="1">MTNIARWVELLSKQKQSCFYVFRLDGIGLLRQLLFEEFLYRKVAPVAENCAFYLVNNHSRTGTKAVVMGLGGKAHQFVRDVNETKSRGISIIRRFTGGGTVIVDECSVNTSLIASTQFAKDICPTDICRWSYDNVFSGCGIFNDKFKCIEGDYVVEEYGDMESNNSTGMGDAEQSPLIYKVAGNSQAFNNKAFVHHSVFPWSISPLISQVLLRPAKMPKYREGRDHISFVRSVREALDPDQRLNTADEFEEILCKRAGLKLSNMLDRRVHVEVSVDRKAAEDIGTMFQNDSAHFSEAFIDDAIATLELPSTTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9B3</accession>
    <name>A0A061D9B3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit TMEM147</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Transmembrane protein 147</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0206670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM147 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767695.1">
        <property type="nucleotide sequence ID" value="XM_012912241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9B3"/>
    <dbReference type="STRING" id="5866.A0A061D9B3"/>
    <dbReference type="GeneID" id="24564050"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206670"/>
    <dbReference type="OMA" id="MMSIAMI"/>
    <dbReference type="OrthoDB" id="364439at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869:SF0">
        <property type="entry name" value="BOS COMPLEX SUBUNIT TMEM147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869">
        <property type="entry name" value="SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="185" mass="20280" checksum="7DF4146C25251196" modified="2014-09-03" version="1">MRFIQVPTCIAIVAAPYWILYNKTALKDNFNNGGLALRAIGYYILANGVKVLAMATGIPSLLGHYLIGEEMVMAILDCALCLGLVMPLRGKTNANANVSSIVLGIGLGWSLPENIGRMLFETVATIRDLDQTDGLLYAALRSNFAVLSSVMFTALLFLWQRDKSNRYRYVVMMSIAMIVCTVMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C7</accession>
    <name>A0A061D9C7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768783.1">
        <property type="nucleotide sequence ID" value="XM_012913329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9C7"/>
    <dbReference type="GeneID" id="24565138"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305000"/>
    <dbReference type="OMA" id="ALKDAWW"/>
    <dbReference type="OrthoDB" id="365695at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="819" mass="92342" checksum="5AC01726A9131224" modified="2014-09-03" version="1">MDPPDLAAALDCAVRDLDLLEESLCDLAVALGSSAETPQGSHHRHLQMGAGIMGFQGKTGSRRLRHFRKTFAQVEVPAPAFLRVLHLHLKRGAALLKRCPAYLDQDASAQAENRSSDNRPKGERPIVTSLEDVSGLPRESLLDIVEGRNVPIGAGLLERLPDSSRFASHNVELFCRCYMDAVLDLYHGVLKRVSTFDIFDCIRLRCFFVNMEHILASNGVRHTRLRNEIIWIVLQLMRFALQDAWWIRTDTEWLRTKLPFVCHGKAEAAPGEARLYELRDALNRVSTVSGQHCTLDVRIFRDISRLFGLPQGAGDMWEQLMGGVEEPSEQPDDYIMFKKVVGESKNTWVDVIVAAIVAVANTVLFECFVRQIEALPAPNTITGAASRLEMLNGLVELLHETDFGYTAWAVDLLGPRADPGLLTAFRIHGELLLKGDSTPNGPPLKRLDWGEGILVYVGTLKRINHIFHKEVVAFVDRIAAPVLEVMGKRGGKKLWWELLYSEDKLLVGPGGEVGDVVRGCNKRIRDALCAELFARIIAKFGQAVASGMFNSEQTVFNALALWDSFCSLNLGKADVHNNNYHINKLFEMVEKIKMGNVVSPTEPMECLDDFWAPLLSSERSVTGRRYPPIDLSHYIHREMEGRVGPDNYVWVGGTLRKRLAIFGNVLLMFRDDSALQPIGMVDMADVVAVNSLDDEDNADKQQYMSDTDADLYSCGTTDSEPSEVENEHANFDMTVLHWGWRLRIKVGGSDALMQREVQYIGVERSRVIDLEFMGPEHRERWLRSLKLIHTHQAYRKPLWWPMHSAFFTDRYQNFSSHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9F1</accession>
    <name>A0A061D9F1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="8">U1 snRNP C</shortName>
            <shortName evidence="8">U1-C</shortName>
            <shortName evidence="8">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0305250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768808.1">
        <property type="nucleotide sequence ID" value="XM_012913354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9F1"/>
    <dbReference type="STRING" id="5866.A0A061D9F1"/>
    <dbReference type="GeneID" id="24565163"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305250"/>
    <dbReference type="OMA" id="MMPTGPR"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="149" mass="15848" checksum="320F5B76FE2B7038" modified="2014-09-03" version="1">MPKFYCEYCGIYLTHSSPAGRKQHSLGRKHISMKVDYYQKLVREHFFQPPPYTLAAAPPTGFPPVVPGGVPGGVPAPMPGHIGAPMMPPAGAEIPVRPPQLGFSPDVPPPVGMIPPAPHMPGPMPHPPPPFVPPMGAPMMAPAPPYGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K8</accession>
    <name>A0A061D9K8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L21 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0207640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767795.1">
        <property type="nucleotide sequence ID" value="XM_012912341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9K8"/>
    <dbReference type="STRING" id="5866.A0A061D9K8"/>
    <dbReference type="GeneID" id="24564150"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207640"/>
    <dbReference type="OMA" id="SGNPRWI"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_bL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF7">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600177" evidence="8">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="240" mass="28188" checksum="D0E4533FE80C003D" modified="2014-09-03" version="1">MYRGATWLPALLFSTCAVAFLRRQGAARLPVSGHYRNTAASAILDWPAHDKLAQREDGYDRTGSYAVVHISGVPRWLERGRFYDVNRVQQQVGANVYLHRVAFFQSEEGWYVHGEPYLENVRVLCKVLKHFRGPKMHTLKFRSKKHYKRKIGFRPELTRLQVEAFEVIPHGERWVDEDPIYVPLTRIEQLRRPSLELPKLKRNTIYRLTETEKRMLEGDPLAHFDPVYNQIFVANRTMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9N2</accession>
    <name>A0A061D9N2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0207835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767815.1">
        <property type="nucleotide sequence ID" value="XM_012912361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9N2"/>
    <dbReference type="STRING" id="5866.A0A061D9N2"/>
    <dbReference type="GeneID" id="24564170"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207835"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207835"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="436" mass="48860" checksum="9C1ABF39CDE4E702" modified="2014-09-03" version="1">MLDYRSLLREARKVRFESGLTPLPEVELDELRVSEASGRVIREPSADQRHCLFEDGLRELSKGGYALLILSGGLATRVGITFPKALLPISPVRRKTLLQLHLEKVNRLCALLGKDSVPPRVFILTSPFNHDSIEGYLESQRFFGLDKRQVVLVMQGTAPCLTLDGNDFFPCPPAEDGSDSKVVEAPKGNGALFEALAHCPEFMSQLENLRLLHVIAIDNALSRPLDPELVGLALRCPGVEVLNKCVVRRGSEKVGVFCMGKAPRVVEYSELEMLPDASFLQGTTRVYGNMCDHAFSGEFLRRIIEEQLFKQLPYHAANKVVSYYDQDEGRMVRPDAPNGYTLELFVFDVFQFASRVMCIEVDRDSQFAPVKNVADYNVYNELSAQHRISRQSRNWLEAAGAELGEGFFEVSCLASYQGEGLERYRGARLEGPMYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9R0</accession>
    <name>A0A061D9R0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768898.1">
        <property type="nucleotide sequence ID" value="XM_012913444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9R0"/>
    <dbReference type="GeneID" id="24565253"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306160"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="29964" checksum="44E26047DED5F98B" modified="2014-09-03" version="1">MVYTSLTEAPHNLKEGIDWLMALKGTDGVKNVKAMSEALYNFLADKPVGKMELPALEEVKLISKDFLGLPQLKGPSSVGEILGLPQIKGPSPVGDLQKRYETPMDKTSCMWLKRMWTLNESDYDNIVEAWGLTTEDFIYKLGRVMHATEKFLEGVKISDQYESAYSTEATWEASCSEKPEDCAVVLVGMAPMLYAGLLSLKDASQRAAKKGPQSKEETRLREVLEAVGYVETQRNDNLSGSDVLMALSDVDKQLLYILYDFAGYWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9S3</accession>
    <name>A0A061D9S3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0313480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769632.1">
        <property type="nucleotide sequence ID" value="XM_012914178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9S3"/>
    <dbReference type="STRING" id="5866.A0A061D9S3"/>
    <dbReference type="GeneID" id="24565987"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313480"/>
    <dbReference type="OMA" id="MSEGWID"/>
    <dbReference type="OrthoDB" id="365294at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600181" description="S1 motif domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="139"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="232"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="688"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="941"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="716"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1172" mass="132240" checksum="28D25F130F65E14E" modified="2014-09-03" version="1">MLRIVFLWSIFLGTAASLHLAVGGRNGRRPAFACHSLQSGHARTRSVPIFAESTPLTLSQVEQLEREYVGFEAEEPKPPKCPVLPQHLSNRVVKGIVDHDMEMLMKRSLDATGRPQHLHQLWKIKKHRKRLNPVLYRVGEKVKGRVAITFPTYALVDVGSTSYGVLHARDMSEGWIDRVDHSLSSGEDIIVTVKSIDEDARFIRLTLLDLPKLEGPTGEPIERRPLHSFRVEEAVSGVIRRRSPLGYYVDVGATVDGFLHINDRKLPRKYTGVARQPFRIGTRIPTLYVKCVDLVKNRIQLSENSLAEELEKRCLTGQETPEQQAVYHPGNRLSMLQSLQANDLEKMRMIGGYDDLLQEVGAGRNASKEYVMYLQNRKKVEQLQQLKDTVLDDADNMDDVQLRRATKEYNRLSMEIAELNQESNEPPPFRRTVYKYGDPGVWESRVYTPFDEKNPRDYFQKVTEEVTTALRDVQGENFDFKGAMADDLHSAERRGEIVEHLWDMFHAPPSDKSQIEDTEPRHATLEDIEDLLPESEIADETQSAWEDGPDADEVVAKLESYDHPEAKELAEMIRSASGFDPFAHSNRLIDDDESAILGACAMANDDVTTWQSRLDRMYEEAGIDPMDVAAATLAGKTSGKLKKGSSSEEHDILMQPFARGDGSISAVHNVDEYVDSTQGVKSEINFLAPQVEGDDDTDYVENSESSDSESTVYDAAESHNSGHDNAEPEDAERRSRYTENHDVYDKTAADSRDSERVTDEDDSSFYSDLDNSYDTSSGEYSDDYDDDEESGADDASDIEDFKDVASSIFGSEEPYKPATTAPKSRLSQSHNLGNTRRDMPTAEHRTATPATDEATAVSTTLPKGPLEPVEKYYEPPTITDDIQSIFNEVRALTADATNEDTPAESAAYPSKFENRDNKKINHQLYIQRNRHLDPVTRLYVMSKVPPRPLPPKPEDEVEDESDSRTDSHGRSPSTDRRAEEGFLRSSNYGDDVGDAGTRGYVDHQDDFSDIGDFDSSDDADDEGEERLQSPEELKKVRSLVRSVVNSDQRRRTLSRIARKALPPEEMARMLRFGRKRPKLTPYTYFPEGIGAAGLGEDRRSVNRRIRDANLKLTKLKRNKRFLSMLHRLDVDPDELTFDNIHQLLPFELVSSRPPPFRKLMGIGESNLPDEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U6</accession>
    <name>A0A061D9U6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769662.1">
        <property type="nucleotide sequence ID" value="XM_012914208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9U6"/>
    <dbReference type="STRING" id="5866.A0A061D9U6"/>
    <dbReference type="GeneID" id="24566017"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313780"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="503" mass="57264" checksum="F76FDC3FC6D45A47" modified="2014-09-03" version="1">MQSQEKAYNDYANSFDGYPIEESRGEKHIMYDGGVHPDVGGYVVPYKCEVNESEMKESELHNTLLRKRQELHEKHNSEDEKLKKTLEEGEQRRKDAEEWANKIDDILQREKSQVDMVQSMGDVLGEVEYIQPIPKTYVPLGWIGNYVSRIPKPIPPVIETFPHEYNPVNPTHNESNVTTNLSDTTSLPEIDLSIKVFNPVPSQTFNDYDYKQSIPKQAAPKVADLDDFSLKDADRAAINIPMAVFPDQSPDDINEYVCQNPWYVSPFSTSVTSPPTTPVPVTDHLPTPQTVREMLYWFVGLNQYGLIGKIKDYVESILVECNRDAIEVTGDSDQLTASMVTDKLTETCLYSATVIYKIKYKDISDVFKDFFNDPDKYAFYYSSETAGLLCQLRDYVYACHYQLQFLKAQCERDKLSGGWRDCHYGSDITASEYPLQAFLTDGWDSDFETHLFDPCNLCHKSRVRMEFKKVDLPMISQLGSVISTILSPSCGGEEHGALVNTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Z1</accession>
    <name>A0A061D9Z1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767915.1">
        <property type="nucleotide sequence ID" value="XM_012912461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Z1"/>
    <dbReference type="GeneID" id="24564270"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208830"/>
    <dbReference type="OrthoDB" id="10287000at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="297" mass="34807" checksum="A0771ABC085082A4" modified="2014-09-03" version="1">MQRECLLIPPTSFREAMDWLEAVRSTAGIKPLGEAVYALIRESTTRTLRLDLMHSVKTNVRNFLRFEGFTGFPSFRLMLDSVTGYPSPEHAICLNGDKHDPEAVKMGVKGYCDVTEFDTLQYEDVHRMVYETIQTAHYLVDGIKKVESYEDSYVSKPLWDVSCKEKPQKCAEVFIGIIPMIYPTLFELYKYTQRFDNWDLHIKTKKDDTLGWLFEGSGYTFYKDLKGKVNAEDIEITIPYVDMDYFKKLYHLAGFWKFYPQSHVYPQAYPIGDGKEHTVGENHDPYEKKYRARRMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA16</accession>
    <name>A0A061DA16_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0312660</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769549.1">
        <property type="nucleotide sequence ID" value="XM_012914095.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DA16"/>
    <dbReference type="GeneID" id="24565904"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312660"/>
    <dbReference type="OMA" id="YYYASLT"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="17">
        <location>
            <begin position="1684"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="617"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="824"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1353"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1363"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR97363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2444" mass="277104" checksum="CD7FC7CC785CCFBE" modified="2014-09-03" version="1">MQPGRRSPRWSLLGRRSGFLYNVVPTTVPDAACVTQPRAHEELDFSLNRSTSGIPKNATESSGKVARTALALYFVSEDGSEWHTAVVHAPYFYVSVVGDYHVDAVIDFLNAKFSSNNVGPALLEHCNRVDLSLPNHIERFDPQTGRPMHGIRNLIKISFNTIDQLEKARSVVQALKRDAEKAQRVPDGGSGSFSGSASGTQFVTDDYTLQQYEAASLSGLGLGSAVTRDSIANDEGGKDAECLSHLGDIYEHDVKYVNRVAIDLSIRCGTWYEVERLPDAVRLTALNKAALPPVNVFAWDIECYKAPLKFPDVETDEIILISIMFNGQGYLIVNRCVVAQDISEFSYQPSEEMAGGGCFKVFNEPNETDLLQRFFTLIVSLAPHIIVTYNGDSFDFPYVQRRAELNGLSMEKSLGVYRSGSDVFTSRVMVNMDCYKWVERDSYLPFGSRTLKQVCKIKLKYNPAELDPEEMVPCARNDPQTLAVYSVSDAVATYFLYMKYIHSFVFALCYIVPLPPNDVLRQGSGTLCENLLMAEAYAHGVLFPNKHKQSGIRYFRDPVTSKHHLIYENSYIGARVETLRCGLFRDDLEERFELSSQKYQELLDDLDMTLKSWADSNLSNDGSTDAGSDGSDSDTAMDDQQVDDPSQTATSGASVDNGSGTADKSGADGGDTEMMSAEDTSQGATPSGANGTSNSQKPNSDLRRPPSWLRRRFARFANFEDVYRDIQERLCRLRDRPTFHTFPRIYHLDVGAMYPNIILSQRLQPTAIVTDEFCQQCSYYNESSVCQKRMQWKQKLEISPVDRSHILPLMKDLESRTYRSTTIQYTPSDRIEGGDSDSSGEESDSPHPTGGRETVRTWHQLGDRERGAELQKVIKAYSQRVFHKMKLNKEVDAESIVCQRENPFYVQTVLKFRDKRYVYKKLKKDAETELKSLLRQPKGNTVRIKEARDCILLNDSLQLAHKCILNSFYGYVKRGGSRWYSMEMGAIVTYAGAEIIDAAQRLIRDIGTPIELDTDGIWCMLPDVFPAVVDLKYKKGSSDSGGAKTVELEYMTTILNRLIESRWTNDQYLEMEDVGRYRRVRRNEILFELDGPWHAMFLPASEKSEDLLKKRYVVFNHQKQIVELKGFEIKRRGEMRMIQMFQEEVFPRYLLGSTKEEAYQSAAAVGLSYRRSLDSRATNLEDDDMFDLLVARKTVKNPVIKQGQQKCFGITTARRLAELFKNESYLHDGNLCMSFLLAAHPTAAPRTARAIPIQTFKVEDSLRAQCLARWLKLQLSTAMNSGVRDILDWDYYREKLDTQLLKLVCIPAVLQGLDNPIPMIQLPGWLKRRREVSDNRQLDIASFFSASKDTKGHVEAAKKRSSEPTASAESASHASNGAVTFKLENVKQPNPAPAPLSWIKALKKQWRSLIQGFHKYRRNLRHDHGYSSYIGLKREMLEAAIAKDKTTDASSADIATAAPKSSIDFSNMYMLLTERWHVYSCRLDPDNPGVMICVVSLQNKPVFATVRVELWRKIYVNCLNEWDVKSNENIKVSIINERYILPRGSLQKNLIELEMRESYFQQHIRNSLSSIFHKTVLGIYEAQLPMSFDFAVKLGNVVNVAESDLSAAVTQSSEFKSCSLQGITSLNASDPRYMEDVDVVFVHVLHGVNPDTRRRNRVFAAVYRKGNDTVNQLFVGGASSQFPRLESEFSGYLQSALGKQRSRYEGRESIHHERYSNPERFPECFGELYDHHLELGATASAGCRGALRKLENYLQTLQPQVLYRKCVLYVYSTVEDSDLGEWVSGEGCPVQWDRDVNADHRQLPSNGFVGKAIEASLELLSKQRSEVELKFAMSRIASLPVGNLLGISVVDANKLVLDVMYARALRASSALLWGTAEAGCDIGLPHAVHMQASEYDIELQENTFRMSSPGVYRGYGAKISFNQTLMYNAIMLESRSVDAPDLAGCDLKKSAPDYGPEELQHDMRMAHTAEFHPLAFRALGGMLDNLIKLTNTVFEKVEYGTFQGLMNICSFINPWLSDPGSIMYDSALYSRAILCTQQYLASLLQHVEHFHQLRAVHVSQSYVVVDTNTLSVTKGRNRVHEAFDNLGSGDSRFRNIPFYLEEEYLAQVQLASDCYIRYKNYVDATHENCTESLKPLEYLPGAVEMFIRYFMKTIALNPLWKTLGEFYEYDVDEAATDVAPREPLALLERDNGELCKTLEKHIVHDWLQPGKFFSRMCDLLENTEEFLSTFDSQGTFGRLEIPNMPGSMVYGSSNWRLEAVKLVAHIMRIDRAIDWNDLAKITAYDEKRHRLFTIAGESEYSAVDWISPMRRIELRSVCCSECFMVFNLDLLSSFSSEEDEDGVVTHFWRCELCGARLSNRDIELRMIKFLQHLFCAYQAQDTLCRECRTVKQLPLSRICQCGGEYVPRLSPERWEHSYAVMVQIADLTEMKCLQEVLGAYRDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA17</accession>
    <name>A0A061DA17_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">-Autophagy-related protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0400530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769747.1">
        <property type="nucleotide sequence ID" value="XM_012914293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA17"/>
    <dbReference type="STRING" id="5866.A0A061DA17"/>
    <dbReference type="GeneID" id="24566102"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400530"/>
    <dbReference type="OMA" id="CNQKEIV"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="254" mass="28498" checksum="CABF5025D096424F" modified="2014-09-03" version="1">MRRVHDILTGAAGNLLPTTGFDFSEKGAVTPADFMAAGDAIVAEDSRWEWVSDGSSSALDCLNADKQYLCAYDIPCLRIPKLVTSEVGDWKLCELARDAEGPAFAHRTDSEIPSLEPRIVEGDCNDLYDNGTPSRPYRRYDISITYDRYYETPRIWLIGFDAFGLPLSHNEMLNDVPSVYAGRTVTVERHPYTAELNITVHPCYQMEALHRQKSSNAAYRPENAITFALQIWSSVLPMFCLLSQQENCQSQTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA25</accession>
    <name>A0A061DA25_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein C9orf114 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767945.1">
        <property type="nucleotide sequence ID" value="XM_012912491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA25"/>
    <dbReference type="STRING" id="5866.A0A061DA25"/>
    <dbReference type="GeneID" id="24564300"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209130"/>
    <dbReference type="OMA" id="FFPIHKD"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="403" mass="45962" checksum="B37506EFD90C4B9D" modified="2014-09-03" version="1">MEDELTFNIVRSKKRVKERWTAEAKEARKSWRCSVESHTYAESKAAQAQAEPAAAPKRSNDVSMIQLLREIPQRVPFRGKPTKRTVSVALPVSLVYNILTDELRAYVIGHIARAVTIYGVHEVVLYNDLGPEGVEWQEYFALNMRYLETPQYLRKYMFPITDHLRHAGLQNPLDAPHHLRTNEWLPYREGVVKLEPKGMARHASSLSMYAECSLFGRIKVTNPDALLEIYGVEWFSLEDTDEEEVYQRVTILLDTSSMSECKRRWKEQKAGTSVSSGTELSGKIVPPDEPQSSAGLYWGYVVREAEDYAAVFAGCPFNESGTYDYKMGTSERGDVYPKEVRVPNFQHMLMVLGPVSGLESITENPQADVDAYVNFCYNQRSRTIRTEEALTICLSQFFAHYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA41</accession>
    <name>A0A061DA41_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD domain, G-beta repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0313010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769584.1">
        <property type="nucleotide sequence ID" value="XM_012914130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA41"/>
    <dbReference type="STRING" id="5866.A0A061DA41"/>
    <dbReference type="GeneID" id="24565939"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313010"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="46553" checksum="0CB9DDB37208A796" modified="2014-09-03" version="1">MEKYNVGVQTRCDSGEKEPTFDDLQRRLCRLITDRCGRSSDEVDIQRIMGSTLFYSETIEMKTDCTPQTTYLPKDPVTSMRVKSESTYAVAMRYGEGKARDAGIGKVYLVDIESRVPSVKMCCLGGVTKLAFANHDGMLFGGSLNGSIHAWDTNSMVEVESILPSNDQGHVDPIVALELLDDDTLLSADAAGRAFTWSLRNLSEPLSRLPWETLRGTSRVSKTCRGSVLYCGTLDGHVYGCCVSGEPSESHRIHDNIVTAMATSSNDSTGSQPPLSATSVAELLATGSFDCYLKVWDAQNLGEPLHELVPAFHAITDLSWYVPAATPICHTRNPALSEVLASVDESGNVFTWSFSINNQMPVCMATVEETCTCVEWTPSGRLLIVGGNGVTVFEPSVDVLSPDPDAPESAFVALRSTRSFAGPMSKMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA91</accession>
    <name>A0A061DA91_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769817.1">
        <property type="nucleotide sequence ID" value="XM_012914363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA91"/>
    <dbReference type="GeneID" id="24566172"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401230"/>
    <dbReference type="OMA" id="HYSFYYN"/>
    <dbReference type="OrthoDB" id="363526at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="267" mass="30274" checksum="6114CF563A0B4727" modified="2014-09-03" version="1">MAQHSGRDDVTDKVVLDPDVYCSLVKCAFNGAFQRKTEMNEHSLLFKQLVNTLVDAPSEPSQHNPPQPKTGVLSGNLKESIDAIKADFLDHYSLLYNLQEYSIKERLEILGRHAPVENTVAHETTRATHTPIGETTYAQRADAPEEALKEETSVSQGVLSMIDALKHKFETLNNRIEALDNEIEAEVGDPNLREWEYSKESMHLRGHHDLEGDAELCNHIRNLYAYLSHQAKINDQKIEAMRNRLITLQAHAKILSKRQPNDTRVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAC2</accession>
    <name>A0A061DAC2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768010.1">
        <property type="nucleotide sequence ID" value="XM_012912556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAC2"/>
    <dbReference type="GeneID" id="24564365"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209770"/>
    <dbReference type="OMA" id="IFENWIA"/>
    <dbReference type="OrthoDB" id="361348at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041004">
        <property type="entry name" value="CelTOS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18659">
        <property type="entry name" value="CelTOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600198" evidence="1">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Cell-traversal protein for ookinetes and sporozoites" evidence="2">
        <location>
            <begin position="37"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="188" mass="21643" checksum="5568E742577F143A" modified="2014-09-03" version="1">MKFLVLLSIVVLKSALALNTNFRNRKRDLPSRSISVNDTDVETYLQHDISTEFRDIVRRDIADKTDELISLIVKDVEKLIEQNDMVRPVFLENALKENAKRMIKSGVISIVKHMVPVFERWIVEAIKPPVTSGMVYTALVKPIGKSIFDQLYHKFNLPTSKIWDKYDDNIDMSFDEAEEDAEGETDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG8</accession>
    <name>A0A061DAG8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768070.1">
        <property type="nucleotide sequence ID" value="XM_012912616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG8"/>
    <dbReference type="GeneID" id="24564425"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210370"/>
    <dbReference type="OMA" id="WINPSAF"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="236" mass="25699" checksum="61C3DDBECC810506" modified="2014-09-03" version="1">MSLLPRIQRFYPSKMPQTPKKGPTPNATWDLLAYESCLTCAEGGQIDKDATAIRMHVPANVWGGLDVHTQKRYLSKRKLTTAISDVEVTSFINCGGIVSAVEIVGPFSFDESGDYSVFTVASCSCLVDPDEGPLDYLVFHEMVVKRVSDEGSGGSAHCVVDLHKPRLAKVSPLTGRSCIGVQWINGGNFTTVNEKTDGDQLFLALLMKDGSIELCKFDLGCSVTYNEVVSDEKEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAH8</accession>
    <name>A0A061DAH8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769887.1">
        <property type="nucleotide sequence ID" value="XM_012914433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAH8"/>
    <dbReference type="GeneID" id="24566242"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401930"/>
    <dbReference type="OMA" id="PIPKYFD"/>
    <dbReference type="OrthoDB" id="365380at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="272" mass="30593" checksum="0AB8D52258921004" modified="2014-09-03" version="1">MDDSPGKIACGKFTLLVGLVKIGQEYVGDAESEDGIAAIKDRIMHKVLNINNYIKSLCDFYDREKASAQAGRQNAEDVSKTAQHTAMNLEKFVSRNEFFVYSVSVTLNPRVRTPADLHRDSGEGDGVCTITVKLPRDKQRQAFYIRLMLKLISKHSLMLKLTPERATQAARQAKKETDEPEASPQQKSTEATAGYFDDDDKGGAQGAQDCRYVRAGMNSFSSYSFFNQSSMILSKYVNSNVVLREDDQVMAERLLREKQKKRRELQLNRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBE2</accession>
    <name>A0A061DBE2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase B regulatory subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770034.1">
        <property type="nucleotide sequence ID" value="XM_012914580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBE2"/>
    <dbReference type="STRING" id="5866.A0A061DBE2"/>
    <dbReference type="GeneID" id="24566389"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403360"/>
    <dbReference type="OMA" id="QRKLIAC"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000331">
        <property type="entry name" value="Phosphoprotein phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="878" mass="99132" checksum="079069107D493DB1" modified="2014-09-03" version="1">MSRTPSRQSSRESTRQSAEGDASEKPPSRSQSFVENEQSGVWWLYGQARRFFRSYRSRRFEEVKKPVSNAVAPTVEAPQPRSLLRTVSAFFTRGQDNESGPSAKCVAPSAPPLADRCSPSRGRPTRLRWRHRAFAKRDDGRLDGGLSGSDSSNERGRLPAGPRETMSDHEYTIRRSASSASLSSTPMTAPDILDADPFWRDHHNRVVGSSPSRSRRSSLDDTRSERNSDRRPMNSLIQRFTAFRRGDSEGQSDESSNSPFAKAAGGRDRGGPNTGRATHYSPTRDWLHNEDDAGGSDSNSSVREGRFFNFRNKISSLRRILPPSKNAPANADGTVKGVRRFRLLSCRRSSHSEREDERYSSGTDYDRSPRLYRSSFHGDHPGSGSYWRLDSASSRDESGAHKSTDSNANSPLERVVVLTSNPQPEFDLVPICLTKWTAEAVLNLEDTFSSIPLLRETPLANRGDVFQRKLIACQTVIDFNSKKVLQRAIELKRQTLLEIIEYISTTRNCMNESVLRDVIDMVAANVFRSLPPRTKKSPFSNEIDEEEPTLEISWPHLQIVYDMFLRVIVSNEVSSKMAKNMIDKPFVLKLLSVLNSEDQRERDYLKTILHRIYGKIMPLRTFIRKSIDNLFTHFIYETENPYGITELLEILGSIINGFAVPLKEEHKIYLEKSLTPLHKPSSVRSYHAALSYCMIQYVNKDRSLASVVLRAILKFWPTTSAQAEVLFLNEMEEVLNLTESTELSCVVRPVSVRLAQCVSSSHFQVAERALYVWNNDRVSRLLSMHKREVYPYIAPALKQNIESHWNDAVRALTLNVAARLSDYDPELYLQCTQLMHGSRSGSTASLTPLGSFCTSVVSSSDSPSPPEQRTSSHDTEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBH8</accession>
    <name>A0A061DBH8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0403860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770084.1">
        <property type="nucleotide sequence ID" value="XM_012914630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBH8"/>
    <dbReference type="STRING" id="5866.A0A061DBH8"/>
    <dbReference type="GeneID" id="24566439"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403860"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="21853" checksum="9DAFE89B45169B98" modified="2014-09-03" version="1">MGISRDSRHKRRLTGGRFPVHKNKRKHELARPASNTKLGTKLVRKVRCRGGNLKFRALRLDSGNFSWSSKNVCRKTRIMDVVYNSSSNELVRTKTLVKNCLVTIDATPFKIWFKNTYGFDLVKPKGEAAEETDADKDASKLVPKSLLEQFASGRLIACISSRPGQTGRCDGYILEGDELNFYRKRMDKKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ9</accession>
    <name>A0A061DBJ9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0312050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769488.1">
        <property type="nucleotide sequence ID" value="XM_012914034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBJ9"/>
    <dbReference type="STRING" id="5866.A0A061DBJ9"/>
    <dbReference type="GeneID" id="24565843"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312050"/>
    <dbReference type="OMA" id="KIDYVML"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="164" mass="19059" checksum="99E71AAD8F570ABC" modified="2014-09-03" version="1">MAPRPHLRLSAEHLVMFQNHFKLVDSNGDGCINQSEFRLLFRSFGQVITNKRLDQIVEEAFKNAPSTGVDFEAFVNIFVQHFTPPPTERAVREALMLFDKNNTGFIDTRELIRLLTTRGEKLEQSEVNYLFELLGIPQSTQRIDYVTFVEDIYRMLPILPNRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBK8</accession>
    <name>A0A061DBK8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD-finger family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0301880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768470.1">
        <property type="nucleotide sequence ID" value="XM_012913016.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBK8"/>
    <dbReference type="GeneID" id="24564825"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301880"/>
    <dbReference type="OMA" id="CCYIPMH"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="507"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="884"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="2166"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2010"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2125"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2235" mass="249208" checksum="638C60614E38DB87" modified="2014-09-03" version="1">MDQDPVPTRETSQEEDRFWIDTDRQFFSNPNSSLLLCLRNHAWHCRYIARQSRQLLREHEEASSDHSNSQRDSKRPKLTSENAVSKIQVGGGSGATGVEARQEGSNDSGIITVTFRVKHKGGDLAVLSPGNSCSRMSPMHGVNGVDAMSYSEKRGFAVAAQHHMGSYDDDVYYNPVINAKHDNKLKLPIILPCQAPDGIRIALYCTTENSQHVDPTTSRRPGFKTNMLNDMLSPDQVPEIVYGPAPVWSRLKQPGFKDGKDICSPYPKFTAVMKEIHGPVADPVWECPNDMKRRNAAGVGDMLRALGLTDVSPPCTIDYSPKLFSFVEAKSSPLCRRCLGMPKVVCSLCSNMEIANNIPGVCFSNPTIVDHKYELVYNGLDIYHMRTLMGTEKFKPPIASEAPIARPLKRSHDDDVTAVLKEYVETLEEIDATFSTLIERVQAEKKPNFDYWSQVESQMIKSYIDQYNNKMMDNRYNYNTQRQSYDVLRIRLTCTKSSNLPAHWTDHALCSVCGSDEDWDDDPILFCDCCYIPMHYCCLGYKPGTMSETMKQNIRRHKLLHTKEDDEPIVDEDEWLCPCCLFLMDQLAFLSESTAMKAIRVAAGPRNKQTLEFFRDNPPDDNALPLEAVPLPYVVGFEYDNPMERIDLCTVYRRNPAVAFASAIPTGNEGPAGGRAALGDGADAAPKAHPRTTSSHMEYLVPPRITFKWLLECGNIPTTVVLNIPDEEIACPFEKDLRGYEMDLLGRTINQFWSFKRMIKTNLDIASDIFDEILVRYMNEGNLDGMLKLLRHVPKEEANTHNLIHQDRALQQQKSITHKRGRKPVDVKVERTPQVMAAINAEVVRGPEQEIVRDDIYTFNCKNPLKKLVICTRISRNFFVNLRIPVCIFCGFDAYYPGGGPMKRTSNPGTWAHIRCAIAVDCTITPKYIDYETFVPKVKALKCLVCHNLSTAIVQCSHGNCCKAVHVSCAAASSYCLFSWDQNGKPDILCPQHASGLAPTVLLRKLQTKVQYKNFKKMSTYETNLDGINPKDDVYLSHLLEPNYRSIASVIEQIFNLNPRTGFPIPLYGDEVVFKQPIIDKDCGEKSMTERSGENKGRVSKRTEVRLPLRDKSGKFKVADKSREIQKVEPISDKDFGAESQQIKTTDLAVTTATVSSNNVESDISTSNVQEPADVPMEPLDPTEEPEVSGNYEKIEVDQPEEIELSVEQADATDDVAPADSVTESKPMVEIQSTDQVEKATSEEVSDPNFCRVTKLAKEHCFWCSMGNEDSDEHTHYKPFYDDRCPTSEQIGNLLFPDLDAAKQKGAAMVEDSAVEGSAHLENIPPIVWSEICASTRIVDEKMLSYISDDFIGGQRLISEVVSKSCRASLLGLTRLLNILYFKSKKGSEMCAVFDSLLRHMKTMQSVDEARRNCEIGTNSATEAYPPLPSFTPDYSGGHRVNHPPVDHRKECRVRVKAVLRTLNQTVFMRLEPELLPVSILRVVVSKSNPENGSDVEVSRHYVVCSGCLEFKVIEQEVSEENSVMRKRVNYAHHYKTCRMCNARACSDCLSHMKAARMRTKVSLAPVPLNVAPAPTDAYMSAATLLSQPMYPGVNLRMPRNPPPMPDDERIPSVRDAMISLPLMARGPMIDGLGPHPVRGIGVSAPMSVDARMPAMMAPNMARGPMNAPSPIRHMISRPQIASSAALRGASMVEMAGLPPTKPTMMPICTPMAKSMPSPGVCGPLYSGTGGKTVPGMMDRTPGMMCGGPFGKVGPMIKSPPVKNGPYATTVSGPSFCRDVPPPNGPFVGNGDLNNCPPVSPPSLIEPPDENSEATFLCSRCEDMEGDINVPLLCCAFCSRFDGLLVPVNREHLSFYLNWTSEYCGYAYVHLVCLDWLSYSKVVSPSLRKFPKTLLESPCHYCGVACGATLTCTNNYCNVRFHASCGAWLGCKADMGKKPEGLTTASRRVYCLRHTFLNISRMSQVERKFMIAPPHLYELLISTKHHLSRFYGGVYMSRYCVPNKIRNEAPSRPPLSRIPASTTSTAKRAKPLSKASAFPMNNVNATMNMLNGINYMNLGLVVSKSNFGQPVSEYSMLPDNIARDRLIQALNWTAYNAMNLVGGRRDKKEIRAIIHLIKAGQLKPIHGSKRGRKPKSLDGSNFDNRQKMPMEDILTYCHSGQLDSGEFFCPVCFSIYFERSPGMPGDDLHWIGCDGCERWFHFVCAGVWAEGQVDPNSPSWFCLACTRQRAYKAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBK9</accession>
    <name>A0A061DBK9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770282.1">
        <property type="nucleotide sequence ID" value="XM_012914828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBK9"/>
    <dbReference type="STRING" id="5866.A0A061DBK9"/>
    <dbReference type="GeneID" id="24566637"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405800"/>
    <dbReference type="OMA" id="PAADICI"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="213" mass="23346" checksum="BECC055B8958DD0F" modified="2014-09-03" version="1">MFVEELNEMPVSESFLYAPLVAVPRSKPPDISSALLNERTIFIGYPIQAELVIAQLLYLDHASQKPITIYINSDDSPVNEDPLSSCDIYALNIVDVMSYVKSDIITVNLGKAYGSAALILASGTPGKRLALPNSFTALRQSAVSLELMPAADICIYSKEILKARRQMICMLARCCGKGEDDVLQTIQRGCYMGAQQAVEYGLVDKIIDEYAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBM2</accession>
    <name>A0A061DBM2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770144.1">
        <property type="nucleotide sequence ID" value="XM_012914690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBM2"/>
    <dbReference type="GeneID" id="24566499"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404460"/>
    <dbReference type="OMA" id="LQKCFHE"/>
    <dbReference type="OrthoDB" id="365181at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="441" mass="50174" checksum="FB07F1C751611C4D" modified="2014-09-03" version="1">MQGMYSFFNEPYDFQLVLGITLVGIPELWDGEDLLRYLRTYSFMFGDELALGFCGVSLMEATSEEPRRAHLICDNLITKQRCLQMRVMPIVVADDEVPGPYPCVIVAIRPYCFWVRRTRDSPVLPFMFPKYTSREVVGEEFEAKMLLMPNNQRLLVVATMIGAGIIPTAAAPGGPTTSFGSTTLAFAVPLHLSLFVVKIVPVVYPFHRVALFHPLVDRRHLDVSSVLQLWLTELSGSRAQLLTDQLSHLHRAISNFSPHRLGVSDDLIYAADYRELFSWTWPWNPCVSEQEIERPCRSLQEHGGEGGAPIQFARIKRGARHTGCIRYEHNRKRWVVDLSVNGCRMQKCFHENLYGMVGGLQAARKWRLDYIRNTHNEFDIEAEERIVNDLVDKIVAMDDLQRDGLLCALRKPVPTYEHILGARSLCDIVDGRLAAIGHYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBN3</accession>
    <name>A0A061DBN3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA nucleotidyltransferase/poly(A) polymerase family domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0406050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770307.1">
        <property type="nucleotide sequence ID" value="XM_012914853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBN3"/>
    <dbReference type="STRING" id="5866.A0A061DBN3"/>
    <dbReference type="GeneID" id="24566662"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0406050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0406050"/>
    <dbReference type="OMA" id="IGPLWKE"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="5">
        <location>
            <begin position="77"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR98121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="513" mass="57416" checksum="FAAEE8728BEB3743" modified="2014-09-03" version="1">MSGTEGSVEGIKLTESVVIVADLYRGGTSNKDGQNITIEITKEEEALFNLLKGCAVSNGLNMGMYKCNSEIPHADFRVAGGWVRDKLLKVESKDIDIALEHLTGVEFCNYLNAFTEKHMGFHKTVGVVKRRPEQSKHLETATLSILGLNVDFVNLRSEDYADDSRIPIMRIGSPLEDAMRRDFTINSLFYNISKNAIEDYTGKGIDDLKSQIIRTCSPAFGTFMDDPLRVIRAARFSARLGYALDEEIWNASSHPSILNQLANKPRIAQELDDMLTRGDVAKAFETMNHWGVLPHLVREHQCDLPSDQQISVGCKTMALVRDCLRIIGWDNINRKFLYLSAFCFPLSNEPPVGKCSYIEHVIKCRLKLPNKLASGAKTIVDGSEEFAALVNGLPSNTEEVRERIGIAIRHIGPLWMEALLLCMANEASDGDLHELKDKYEDLVATINQLGLQNAYSLKAPITGEELINLIPGLTRGPYFKEALELQIRLLLRSPHISKQELLQRVTQIIKDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBX5</accession>
    <name>A0A061DBX5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0204130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767441.1">
        <property type="nucleotide sequence ID" value="XM_012911987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBX5"/>
    <dbReference type="GeneID" id="24563796"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204130"/>
    <dbReference type="OMA" id="SAPIELM"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="356" mass="39383" checksum="FBB1658DB6ED8254" modified="2014-09-03" version="1">MTGYYNGLLPYGGQGVPYGGYISNGGYTAGAYYTSGAQLPYYGYYGQMVPSYTQIQPPTTRYHQPARRGNSGGPRRPQPAADGRPTSTRKVAAASAPSNNVACDICNMSFKTSAELADHVDGMHVHCEVEGCGYSAPVDLMSVHALKHVKNQQGEYILESVDETRKWINNRRIRHPLNRHRDMSATEDSTLERLLRDAYRKVRKDAPAKSVLYPVISKVRPRPSALLYLSDPVKYQNLLRQSTGPYSYRASLSMGRAQCQNFKRTRTCKFGDNCTYSHNVQGGSFRELSVTKRPPTLLHVLKNDIFNADKILVSAIRTLVSLDFFDSPDEELCVASSTAAESGSSLSSEKPPTCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC02</accession>
    <name>A0A061DC02_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768615.1">
        <property type="nucleotide sequence ID" value="XM_012913161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC02"/>
    <dbReference type="STRING" id="5866.A0A061DC02"/>
    <dbReference type="GeneID" id="24564970"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303330"/>
    <dbReference type="OMA" id="YFGSHKQ"/>
    <dbReference type="OrthoDB" id="360742at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1127" mass="126764" checksum="6F71F0C20AB45A9F" modified="2014-09-03" version="1">MDPHKVNDGFGDAVDKLMMTADIENRGCQLVSSPPSASSETDHITEMQRLKTLLASPPGGVPVDMTGADPLVRYGSQHGKHVSAESPGAAGSGNRGGVEFLAKQLMHGKGSGAASPAQPNLSNRSDMSSALLKSGEGANVLKHAEAVIEYQRERISALESAVEKFNQALAHTNNMHKNELQRQMDENVALRQEMQKVITEFEVLSQRYQIDMSETEQLKKKVNIFTHDLAKREDELARLQEQMHQLPLDNNELKAKNRMLSKEIDRLNREIRGLNVLDAKINSKPATAAVAGTTMACAAQHEKLKASTKCIAQLENDLQSYKRLTESQSMDIKRLHHQLDKLQKEAKPNNYLLAAQRQMLQIRSVFLQLAKQSTQPKPDAAPISVDEDLNNRSLYAAYNMKASAEFREMYDKLLDVVNRNMSRHVIEGGFYTMPVFYSCDSVNEQLHVKVEESLLIFSREDENQLTEVLRIPLSMVLGVKKKADAKEFYIHTNDSAVHILRSDSRDIYNRLYYALQYAGFISEQVRFSIFSKVDLNWVPTDCSWPLNSAVVVATESGYKGPPPMNMEHVRRALAEVYVLTDPTERLLTIDQNSNSLVVSGPQMSATPFIVPCDGAMAVRLCDPAHVDCDEFTPADPPVATLANGTPTTSYFVNSGHVFAFVAVGNRILFVKGATADDERRLLSLLRKGVYKRPIESSEYLAETPARITSRKSTHLDHPISLSAPSFIIRSRDTMELPTSMAETVAPKLYDFVDGKLVLYTQQEEHTVLEKDNGSYRVNADTREVALLSGSLETYVLSFRTDEELREFTSKLEAQGFAQPNVVEVHQQVCIVTAGCLRLYKDAQDAPIVTFDNQDTEVDVNEERREIKITNAKDESVKMTIDCVSPAEFRRWKFALGLAGFIKGIIRARTGDALKKYIFPIKIFDDEIQSERRAFQVEPGRICLYVNPTIATPFLVFDKSKSALELFDHERRLRLYVNRNTKMEERFDFGLAMLTDYQLLKTALRENGYVTEPVKGKVTRYHFVISKPGLISVHRTKFDADPQLVLERKLYTAEVTNMCIKFVTKGDTGKTITILFKKEFNFKRWLMALKVAGYLPLTPETVPVLYLPTIIYGHICAEIPALLKGHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC56</accession>
    <name>A0A061DC56_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768710.1">
        <property type="nucleotide sequence ID" value="XM_012913256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC56"/>
    <dbReference type="STRING" id="5866.A0A061DC56"/>
    <dbReference type="GeneID" id="24565065"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304280"/>
    <dbReference type="OMA" id="AACYFNQ"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="487" mass="52215" checksum="B134DD2E10B2B1B7" modified="2014-09-03" version="1">MDDLGDVKKVVEAVLSACFGGSLVELQAAVRQMLAIGGKDEADGQSDKVSQHADGTFNCVELAALESLRDTKKHGVAHIAAAGGNLDVLQYILTALPSLAHVEDENGENPLFYAIRAATGRGSSGVNDSDFLSCVLLLLGQCGPNCVSKSGASPLHVACELGALDICRLLVENHADVDVYSDDYGTPLTVAVIRGYVDIINYLLSQGANPDGMTRNSEDGGRIHKCRFPPPLAFACSSGQERVFDMLISAGASVSVCDPDGWTPLHCAAEMGSVYMVEKLLGLKADCNIKVQGKTPYHLAVWNGHSAVASMLSDITVDKGPVNISEPSVAPQEESEPEPDSCAPAFNGSREELDCLVANLKEEGRTFVANKDYANACTSYSKAIALLTGVADTAGELLSVLHSNRSHTYLMLGKLEQARKDAERCIALNPSWPKGYFRLASVDKASGREVDYLHNLFQAYSRDTSNTSMRDLFQREFERARNTSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA9</accession>
    <name>A0A061DCA9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769878.1">
        <property type="nucleotide sequence ID" value="XM_012914424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCA9"/>
    <dbReference type="STRING" id="5866.A0A061DCA9"/>
    <dbReference type="GeneID" id="24566233"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401830"/>
    <dbReference type="OMA" id="IAYRRCH"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="405" mass="45227" checksum="5E1032CFE522222C" modified="2014-09-03" version="1">MGVKVVQSGGDDVAAIVVDPGFDTLRIGNCQEDYPREYIPSALSRGTWNNEYLGWVPLNRVRAPTFVEVRRLLQYNRDENLEVDPFVFEKLIRLGVEGYRRDSCPVFENEEFVSTKVGGLNLDVTKHPMLVTEPTAECKQFRDCTLEILFEQLDVPAAYLAKRANLSAFSVGRQSALVLDIGAGGCIASPVHEGISLQSTIQTSLVGGNALDIHLCNLLHNRGHEFFRPGGSVAQEHRRQWIAREIRESYCSVKSPKIPHTYRLPDGDVVQIDDKVAEVPKLLFSPESTSVAEFNNFKGLYEMITDCVFETDVDIRRELLSSIVVVGGVSMTSGLMDHLNAQLSQGTIGRGSKFKLVHPSSYGEARYSTWLGGSILASLGRFQQLWISKKEYRDHGTTIAYRRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE7</accession>
    <name>A0A061DCE7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adrenodoxin-type ferredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0402400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769938.1">
        <property type="nucleotide sequence ID" value="XM_012914484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE7"/>
    <dbReference type="STRING" id="5866.A0A061DCE7"/>
    <dbReference type="GeneID" id="24566293"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402400"/>
    <dbReference type="OMA" id="SNYNLCT"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF72">
        <property type="entry name" value="2FE-2S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="171" mass="19308" checksum="03A0665A5F7DB4A7" modified="2014-09-03" version="1">MRHRLLSALITRGCHSTPPLKHALANINRRAQCHKRLFHTNIANNNADSVTFVFVNQDDKETEVTVPVGTTVLEAAHKFNIQLEGMPTGPPVMMRRSMRRMYGLLHVSHVYDALPEPEDAELDMLDLAPCLTNTSRLGCQIKLDTSHQGIRVQLPKITRNFYVDGHVPMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCH8</accession>
    <name>A0A061DCH8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease III homolog</fullName>
            <ecNumber evidence="12">3.2.2.-</ecNumber>
            <ecNumber evidence="12">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="12">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NTH1</name>
        <name evidence="16" type="ORF">BBBOND_0207310</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="12"/>
    <dbReference type="EC" id="4.2.99.18" evidence="12"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767761.1">
        <property type="nucleotide sequence ID" value="XM_012912307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCH8"/>
    <dbReference type="STRING" id="5866.A0A061DCH8"/>
    <dbReference type="GeneID" id="24564116"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207310"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596020" description="Endonuclease III homolog" evidence="14">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="221"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR95575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="396" mass="43450" checksum="403DC82C4BF38C6C" modified="2014-09-03" version="1">MAATWRRPWFKLLALALCSLKSLVRGVRNLRLTVGKSHCWIAPAGLRIRVSQSATLVEQPTDTPHLTEILESTANPGHDSVKQHIENILNPTVSLESLVNIMARGKQPRAESLGAPADSEASTATQSPARVKKVKQILAKKPKVEYDNDYIELQYDTKTQPFRHVGENECSIPNFSNVWNAIVDMRQDKNAPVDTMGAHCCADESADKATYEYQTLIACMLSSQTKDAVTAAAMDALKARGLNVETVAKMPEEELDSLISKVGFHKTKAKHIKQATDIIIEQYNGRVPDSIQELVSLPGVGPKMANLVMQLAFKRINGIAVDLHVHRIANRLGWVKTKTPEETRLKLQALLPQKLWAEINHLLVGFGQTICVAAGPGCATCAANTWCPTGRANLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCS3</accession>
    <name>A0A061DCS3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin, N-terminal conserved region family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0307580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769040.1">
        <property type="nucleotide sequence ID" value="XM_012913586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCS3"/>
    <dbReference type="STRING" id="5866.A0A061DCS3"/>
    <dbReference type="GeneID" id="24565395"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307580"/>
    <dbReference type="OMA" id="RYMNQFI"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="172" mass="19302" checksum="008F0459BE2053E5" modified="2014-09-03" version="1">MADLEPVSAPDAYATEPKSKILVLIIVSRDDRPLLIQDLSTPGWRPDPPHLASFVAHQALDVIDELVWTNPSMYLKEVDVFDCLAVWAFVSTSHVRFLLVTRAATWTLPASAAGQSTPLPPPPSCDSVRAFLKEVHELYCKYLYNPLYPPNGLIVSREFNLRVQRIAKKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCT6</accession>
    <name>A0A061DCT6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RuvB-like helicase</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0404780</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770178.1">
        <property type="nucleotide sequence ID" value="XM_012914724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCT6"/>
    <dbReference type="STRING" id="5866.A0A061DCT6"/>
    <dbReference type="GeneID" id="24566533"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404780"/>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="63"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR97992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="484" mass="53836" checksum="8ADBF64A47247060" modified="2014-09-03" version="1">MTHTIEVSDLVKIERVGIHSHIRGLGVDENLNVQYHADGLVGQVQARRAAALVVKMMKSGVIGGRGILLAGQPGSGKTAIAIAISKALGEDTPFTHLSASEVYSMEISKTECLLQAFRRSVGIRVSEETEVIEGEVSEIEIDRFANRQVDPSSFSSAPVTVGKMTIKTTDMETLYDIGHKLIEVMRRENITAGDVIQIDKSSGTVRKLGRTFSRSRDYDAVGPNVKYVPCPSGELQKRQTVTHTVTLHDIDVINSRSQGFMALFAGDTGEIDSEVRSQIDAKMREWQEDNRATVIPGVLFIDEAHMLDLECFTFLSRQLESETCPFVILATNRGITHVRGTNYKSPHGIPLDLLDRLLIIPTFPFQPEDTEKIISERSVEEDVELDDESLQLLCKIATETSLRYALQLITAADLIRSRRRGASVTSSDIRRAFGLFVDTRRSIKYLIEYRNDFMFSEMQDSVADDQAETPSEMQVDKESDDDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCU9</accession>
    <name>A0A061DCU9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0308030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769085.1">
        <property type="nucleotide sequence ID" value="XM_012913631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCU9"/>
    <dbReference type="GeneID" id="24565440"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308030"/>
    <dbReference type="OrthoDB" id="10545723at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="298" mass="32861" checksum="DC4E5E368FB8D058" modified="2014-09-03" version="1">MDNERSSRRAYWAKIAILALLAGALVGGVAYLIVHFTKSDSPMDSDTVSAFDNSDPGSEVVPMPLAEQPEGHERLRDKSDHPIQDADMLPVIEKADGPVPGRDQAPGKNGPQQPARAGFPRERRASNPQPDVPNVPDQDPYDHHMGIVETRIPIISEHVRGQTSVTTLEDVTKDLRLTNLHKGKRCIKFNPEQRPDNSKVRTIANGNIYSAFEPKAPDALFCTVVTNNGQTVVMVNSDVVKTYVVLEKTRYGNIISLFTLDSKSIPSVTQLVKPKGASSYCLNDNYWGLMRSIYELNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCW0</accession>
    <name>A0A061DCW0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769110.1">
        <property type="nucleotide sequence ID" value="XM_012913656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCW0"/>
    <dbReference type="GeneID" id="24565465"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308280"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="6395" checksum="53EC60985DD4AED5" modified="2014-09-03" version="1">MGCALLGVLGAVAGQWVDSAAPWFCPAPLLEFSYELGALYATAVDISGAAVSHNGRVESLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY9</accession>
    <name>A0A061DCY9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0405710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770273.1">
        <property type="nucleotide sequence ID" value="XM_012914819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCY9"/>
    <dbReference type="GeneID" id="24566628"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405710"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596031" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="866"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR98087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="974" mass="110212" checksum="7A33AB7956516B06" modified="2014-09-03" version="1">MDSSSLVKILFVLCGALMHCIRNSVAFHCDFDDPHDLLSSNALVSCHLDFDDFKYAPLVCPHQINDAEYVWHPQPTVGYDARLNTYVVKNGTLVSVAISDVVHSESNNPSVRFRLNPSQTQLYFDLPRHELLAITERRMIFICGPRNLVLSDALQRQLDSLNGDVQTQEHSWTSETALIREIRKFGKGLGVVFLYRRRQHIPLQGCGSHPSPLFAADNEVTVDSNTGTRSCVADPMSESRIGFFCEGLIEPKECMKFLLDHDGKIVTAPRPYPYWNFDMHSPWVAARYFDKLALPRFHGECICKDHSTGQVKARIEIRPKNDYVCDIASKIFRNRHRPIRGPWCSVVLHPGSTLTIKFPTQIATSVSTNERSDEDLYVDVDEDVSSLPFSQLPFIYEYETEFLPRNLATLRQLKTVYGIDLYQEVLYHDVLVGDALELDISRISHGEVMLKYRMGKPLALRSGLNSFYFHWTLISRNDYVPDNISAIVKVSLAFTHQYGILGCERGPQRVFDAAISETNCTTKRVGNGVGNTYECVYDMRHGRQVGIHCRLDEELLPNNCESTGYDLTSNKIMQFTGSYRNVTPYPIRGFQVFDMGAQDKPLSFACVCVDQRGYEKSKLIVEYSQKVSYQYKVRGEGASHLLLPYILLPWREIGLPSEGRFPSKSLILNNVSQKSVMLHVGKTLLLHCGIGPISSFQYERLMRGRSAGMIVTTWLPMQPDVFYYAVTQRAYNTELIRKTYEDSIVSTAGGFRVVYENTYSPEYQRLTITSPRYAILISKDPAHKEYVPMTFVCGKAPEQSDLSLVTGDVPSSGDSAERNVLINESSERYTWNVLDVAVKTTDPYMQGCGVTYESDDLFKPETPKLYDTDGRQIGCKIDIQNVKEAAFYCPAPYVLDPPNCFDQVLVEGKVKNLSDISQSIVASHSNHFVILQFDSSRIGRGETLRKTPPLECQCVTIKGVILSTIQIKHYYSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCZ6</accession>
    <name>A0A061DCZ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPSF_A domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768021.1">
        <property type="nucleotide sequence ID" value="XM_012912567.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCZ6"/>
    <dbReference type="GeneID" id="24564376"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209880"/>
    <dbReference type="OMA" id="CRDFNTL"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="2">
        <location>
            <begin position="614"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1443" mass="157512" checksum="A28D28F4FEE3880E" modified="2014-09-03" version="1">MSRLYTYFVTSAPGGATQGALRCRLARGSEREYLVCLKKSRIDVYSLEKVGQSDAEGDERPEAPTLTATIEAHTNLLTFIEFRPPGADQSHLLALTCNMLLLLLTFDAAAGKFASRPLVSLQEIGAQEIESDVVLRIDPGYHFILFHGQKKTLKCVVLDRENYFNIGHVITMRTGESTFLDVAFLDVALREVSGPAAARRADVGANMSASRLAAASESFTELSRSKMRKSVLESKMLLIAAHRRGASAADDGEGAEFWYCGVQLFFEIEHCDGDRRFTAYGCSPLFGESVPLAERFTRFVPLKLNAGPRCSDGALLLGSQAIGFVSFRDPRNVKLFHMDISVGEITSHCTVEENRRYLVGDDTGALYLLDLVESRTPINSALKRRVEATDSSLPASKIANVGTCNSIVDVFATKVGVYSPPSALVMIAPDLVYIAAVVGNCRTVRITGMHHGDGHASHGLMSAFECDDAMRSVESRDGADHKHRRIESSENWRQTNLGPILDFTFGPQRNQVAAPILACCGYGAEGRVCSITLGVGIDLFASHTLEGVRRIFAVSTSNGKSAITEVVMCCVFFNYTRFYKIALPGTGHRRTSARTVIDPVDQPRWVVAPVSADSIGLTTNARTVLFGRYGSNRIVQVTSLGVSVVSANGNDFPPQYFSVSDICSCAGVVANPDAAAVAVVDAHWCDGGIFLLLSTHVALVLSIEGGMRVPRWRQLSKQTSATAYVSGSEFKTARPSGLIALATWEDTEVVLLRDETLETLHRTKVICGYGVAITALRFGIIEDKAFLFAALSDGTLVVHKLTFGKTVGDNKSSFSSGCVGMTLENIIKISEDPIGLATLVVTPGQQPGRFCRLAASRIVTTGANPMLIYANKGKVEYVPVNAPHIATICSIDSGRQVGHVVPLLYTCNRDQLCIGELDSTSQLHVETICSGRSFDKICYHSESDLVVVGCVGELVADSESSISRRSAVQAHRSPTRDSEGAVPRDGTAFRCIDVSSMIPLPGICKLEPCAKFICLKTKEVVHTLKIPSRHVVSGVTTVAFDGHRTMIAIGTSRVSDQDEVPREGHIYLVDVVSSGPDSWNIVFLRTVTALSAGIVEMTACSNALVVALNDAVTVMTLRREDRPSVSQSHAQTAKTHKLEAVHASDDDYGSFELVERAEYKSCTYVVSLDAYKDVIVVGDLMNSARMLRWRGNELREVCKDFNSVYCTAVAAIDKTHCVVSDSSGNFHVLGKPGSATNDLEAMRVEDAGLFHHGENINRIRANPPAENTVPKVESAHGRDMPTFCTTTQCDRRFCCLQGDVPVSTPHDVSDDLIRGLSRPNKFWNYGFKCVLTCATSAGSLIRLCLFEDDRLFYRLGLVEEAMNRVQKKVGNISNLHWRSFKNRWSVSPPRAFIDGDVVESFVDLDPSLRQQVFDSIAEKESQGMFYSHELLALEIEHIRRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD18</accession>
    <name>A0A061DD18_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MORN repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0210230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768056.1">
        <property type="nucleotide sequence ID" value="XM_012912602.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DD18"/>
    <dbReference type="GeneID" id="24564411"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210230"/>
    <dbReference type="OMA" id="VPNETYE"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AVL9/DENND6" evidence="3">
        <location>
            <begin position="140"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="876"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="954"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="973"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1763" mass="193165" checksum="34DB6F6342F2E7FC" modified="2014-09-03" version="1">MWEFDYYNRDAARHAHSGQFQAQSRAAVGMAPQGVPYAVDRFGRPHANRYTTGDFVQDSVFYDVSDETVGVNTAELDLSATDENAERMALYNTELHGPPIVGATIVRHDETRINVDFTHPNRLRFFTSAPYSNRLRVNDVNNWTSKGRSALYQLEASFHLVPRLALGSMQSSTLVDFVYFTLPTPSGNYLYGVSYVAKFAVVKEEPKGFAPPTTQQRLINEAVQFLERSKGVTLVSKNAVGVGGAQGNPQEKRRQYTYVAICVISKVPFFSYIGSRLECIAQTYFHNKCFRDYQLLVSFVEQMNSAEMVENWSYESLYANLEMYFKPVALCLSYRSLLFIVKSLMVGRKITVYSQSAARTSTAVLAMLTMIPGASALGFNSNGFGSMWHSWKKFAMPLQLFHSQNMIFPYFTMEMVNLVKGVSGYIVGITDLKIIQCLDQLPDFLVNLEQNCIQLLNGGLLQMFHPSLYEIQHFDSAAEPEYDSEDDEIVKAVSSTGGAIYSTIGGYLSKTPSALVDISGSLKRTIGNRVSRRGVIKCNESALGLLDKYFPGTVPNWLKKCNTSKRSTVASKAQERYDDDEDPSAQPDTRVSASRPFSMHDMFAKMAKHKSHYHYFGYVEHIHVSHHDKERIREVEYAINYRINPMQEYLLKFLSDVAYVCGEKRMLHQLLMDFNFDVKALTDCAQTVTGTVLKRGDCFFRGDLPAISFLESSYKNFFPEQQCDCDIPCPGEGEHHEFCDYGDPVSYDNDFTVIHPHDKTYHQCSDNTKQCAADTAKTEKSSPADAALEFFKSLSFSKFAALFAPSKKKESAKSDGGKDAGKQPGSSGLDDRDKGRSKRSTDAVKDAKEAAKAATKDEKGSSDAGTASEPAKDGAAEASAAASDVQSANDSEKQPAADEPTEGEKDAVSGETAPEQKEEPESTAESAPKTDAEAPSESVVDSGTAASEAPASEEAEKVAEEHDAEKAPESEQTEPTAAQEATASAEDAAKAEQPDDSNTAEDAAEAETQDNSGPKDDGDAVENTGEDSSANAAKPAEPDANNGTADATNATETDAKSGSETVDTAAEGDSSGAKDAAAVKQDGGSPAENAAAATATAEKPSESAEAGSDGKEKSPEAAGEGAQKADEEKSESAKPGFFELVRQFITGEFVTDEADANAKNEDDVENNELWNDTHEYDTDSTPRYEPNATANDADGAEKPDEEVPRETKDIDFFAGAKASVAEKSNEVPAARQSVGVNEVQVAGPSPNVQNDELMKEMKKEGDSGECEKKGCQHAHEDEKDAGTSDVKQGKGGAKSAAPIRKSFTPKKKVYPTQRNYRRSEDEEIKFEVVGSVATKIMELQCNHGIDFIEMWVNSLCAQQFFEENELATFSEPVYFSKSSMAKQKYANGDVYIGDMKYMKRDGKGTYITADGTVYEGDWVGGKRHGEGSLISEKQGYKYRGQWVSDKRNGYGELQTPTFIYSGIFKNNTFHGTGKLVHAGGDTYEGDFENGQYCGRGKLISIDGTVKIGSFRNNELQGVCSMIKPDGRIYVGKLHGEVLHGPGKIIYDKLVSFEGQWDRGIRNGQGAVTIKMNDTEFSATISIEGTWVNDSLVMSDVLVKFPGGYKYVGTLAFCPDLNPLLRLPSYDESVFTEAEEVMSTFSNRILPHGGGIIKAPSGSTYSGDLLCGMRHGNGVMIFHNGVSYNGPWAYGTVHGVAEVTFPGDMPQKRLIFEYGQLLDELDKKQRQLVDECLMEVGRPTFEREFTLRNLEPFPGLLRRVPAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD49</accession>
    <name>A0A061DD49_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769285.1">
        <property type="nucleotide sequence ID" value="XM_012913831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD49"/>
    <dbReference type="STRING" id="5866.A0A061DD49"/>
    <dbReference type="GeneID" id="24565640"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310020"/>
    <dbReference type="OrthoDB" id="367147at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="350" mass="39691" checksum="60EE5BD8C586CEA3" modified="2014-09-03" version="1">MGFQVELPKRNVRKLASEVGLSIEVPPHEDRTFKDVDLDDPYANTADILKDELRPAEDKGFSGLSQTNFDLNFAPEHIGLEGYDDPGMPRDPARKTDERVINPFSTDECLNPWSVNTSTTDITPPTAFPPSATDNLPPPKSVREMLYWFVGLNTQGYVGLITDYIYSILKDANKNVSKLSDVIEVTGDLSTLDASMVTAKLTEACLYSATVIYTIKHRDNYASYKDFKFESEYRTFRYSPDPSCLLCQLRDYVYACHHQLEFLKAQCSRAKLSGGWRDCHYGSDITASEYPLQAFLTDGWDSDFETHLFDPCNLCHKSRVRMEFKKVDLPMISQQGSVISTILTHSQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD64</accession>
    <name>A0A061DD64_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768176.1">
        <property type="nucleotide sequence ID" value="XM_012912722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD64"/>
    <dbReference type="GeneID" id="24564531"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211370"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7048" checksum="486863A02068FF3A" modified="2014-09-03" version="1">MGSDTLADHPAKKFSAYVLNMTLFLSKPLPKMELGSVVLYVWKKQKTTEHVDGVNPESTKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ8</accession>
    <name>A0A061DDJ8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0313910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769675.1">
        <property type="nucleotide sequence ID" value="XM_012914221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566030"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313910"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005156862" description="C3H1-type domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1805"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="877"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1867" mass="208027" checksum="C86661EC0475CBA8" modified="2014-09-03" version="1">MTLTPSSLALVTLLVNLEDFVKKAVKNAIIAVINSNEELKHLYSSYVTNLSESVKSAGQADGTGEIEKLSKQVSQEIDDINRLLSKPNNLHYNSLSSPSPSAELAKLQSKLEALKKVEKLCGFLTNLNTKQNEPKNLLVNLCDGLQTFLGFNPSSKGYTGDGIVYSDLDRLCDGVMGFLSGVLSNIKEHLGQHKETITPVIKILNTNKHGGKKGFNAAIGSVVAGVGRYNDGVRKSNLKVRKQIENFEREINTLKMKINDINENIDIRFHSEAEKAEKSVRNASSNCQQYAATFNETFNLKTKTEMKNDINDLNHPLSLKVIKAVGFVKDESERFKKLSDKESRDFDTMKSRIESVCTDHGKKVNAHICKEVTELVTKLRMLVRAILDELKKIEKNLFEYVQDLTKWIEQANTAVEAALEKVHIIITAVSEDSVFSNVKPIKKAAQELYDRAFELFDAGNKANKAADEHVKAALAQVKEMDGKLKEDLFKVKTAIRSAVNGINAKITALGNKFTSITKGDSIEGIVEHIRNTINGIHGGTRGDTGLGAIKQIIKTYVSKSYTGDQFAAKVAAWVGEIVISDAINGKLKVYVNENTGRNNNYFKNTTTTKSVTEKLQKMLIEEIKKLFAEPRFTDDSVESRLKVIQQNVKAFGSSLLSSVDSKLPTIVQAMEDDEELKHEAKSDTAVHIKRNLQDAVTSTFKQLALRSTTAAMELNSLLLEPRFKGKAQTSASAYLDNALRVADELYENLKVALRDKSDRDQNHAKAVDNAITEVTNVLKNQMPEESAPKQGSHVKLEGAPSFTQYNSFVDQTEDKLAALSNPDFNTIKEAGTLPAAIGEIQRGVEAALSEIGIINGKVQDQFNTLTSDFQQLCEAVMKAARDDKDNAKTILEKLKNTYFKHYDIKKKDAEDSIKKIKHDLETLRAGPVTRALTFGEQFLKPEADKLRDETTEKLKQQIDEEVAKAKKELTTRARIDYVSTMKMLLLHYEDRVTKELTGIRQEISDDLITGFKGFMGTFAGENGRTVSDVNIEKLKSVATTMSSTKYDPKQFTDLAKQFQSFWHPLNTYLKKEIKRAHAANNEKTNPEPTDVEKLYTSKIDSVTNELNILLNHLREHNRYDNKMPEMLDILSTEVDGLHPESFSEPSTPLLDGISKGLGKFAAELSKTYLNAYDGASDGMVLVDARNDKVTDDGNKCAKVCLSLLSILYSEFKTLLKYCVARCKSDQININTELGKYFATQGYKVTEDGKKHWELQDSKGMTGLFICKRMFGKDEHHLYYIDKSKQNALDTLHDCLQTYYQVSHIATFSARKRPCNIFEMLCWVSGLPCNNVYQDMLDDAISELFVDPSKQPEDADGIPVTYISDEPLPAYPQNIAMDDTQRAVKRLCSRSHDILTTIAGTGDAYSMYAVDYSTNSLNFHYPSKGEDCLQMLLDILRRLLPSLKFLHTQCGLSSAYHGWSGCQYGRGVKHSNWQCGEHPANESTDCLPRSPLMSYLRDSLPGCLPHQLVSAGCKSECKTCPKSLPGAPCITPLGFRGFSGSTKTGKDICTVLTKFFDNSNINALFGLLPKPPSTLPEHFQFALTLSSMLDNANAASDVSLAFVTKTKALSIDLYKETSKLTGALQNAYRNQAGHTSSDHSKSTEADLSSLSKDSCNLPHERDIHCAPYLCSTSSDAYTYLAKKHADLYLSWAVYLPWTFYSYLKSLLDAFQQIDCGGSGCTKCSCKPGKHGVEYSCKCKALISCRGVMTTFYQYGFTFGDAKTLYGTNRKFCLSFSTQLSNLLKSQHFTKLFEECDNFIWTIREPFTYLVLALWSLSLFYLVCVMVGRLDVLHIKSHLRSPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDM0</accession>
    <name>A0A061DDM0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0302740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768556.1">
        <property type="nucleotide sequence ID" value="XM_012913102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDM0"/>
    <dbReference type="STRING" id="5866.A0A061DDM0"/>
    <dbReference type="GeneID" id="24564911"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302740"/>
    <dbReference type="OMA" id="NFRTEKM"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="119"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="198" mass="22350" checksum="0664FC76816588F3" modified="2014-09-03" version="1">MSDNTLQIVVKILSDLGYSMTLKRLRKEVGDDKLRPENVPQAVKAFNFKALAAGLLVKEGDVQPEPKVAPKVETADASTPVVKPTLKKLVFVQSKTEKPSSQPEKKQVMTVDAEMPKGRFKRIQDEVWLDRIEKEELKENSYLMKNDDFSLKAAQELIQVKGKNFRTEKMKKKRASWKGSGEITSHVNSVQFDDSDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDT1</accession>
    <name>A0A061DDT1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768731.1">
        <property type="nucleotide sequence ID" value="XM_012913277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDT1"/>
    <dbReference type="GeneID" id="24565086"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304480"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="62" mass="7260" checksum="F336BF2B56CCFA9E" modified="2014-09-03" version="1">MGMGIYIRDCYTVYIDSHIRKEGTPGFLCAHCLMLYMNCIGHYHYIRHNTRDSNYSPPNSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE17</accession>
    <name>A0A061DE17_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770065.1">
        <property type="nucleotide sequence ID" value="XM_012914611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE17"/>
    <dbReference type="GeneID" id="24566420"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403670"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9886" checksum="4EBF9123A929CC99" modified="2014-09-03" version="1">MRLSGLVPYVLDPPGCFYQVSVNGEVKNLSNISQSLVASRTKHFVTLRFDSELIGPGEKLRQSPPLECRCVTVKGIVLSTIQVENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEC4</accession>
    <name>A0A061DEC4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769221.1">
        <property type="nucleotide sequence ID" value="XM_012913767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEC4"/>
    <dbReference type="GeneID" id="24565576"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309380"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="6711" checksum="CA2935EF724F72FB" modified="2014-09-03" version="1">MISHMSSEVTITPAVLPIIIVPASLIILVIRFMTIFRIRPFHKVRNFCAPKMNGLHSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEM1</accession>
    <name>A0A061DEM1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0400143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769706.1">
        <property type="nucleotide sequence ID" value="XM_012914252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEM1"/>
    <dbReference type="STRING" id="5866.A0A061DEM1"/>
    <dbReference type="GeneID" id="24566061"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400143"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400143"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="12"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="332" mass="35955" checksum="A7E8DFB029B9282C" modified="2014-09-03" version="1">MPPESRVDNEQVYYFLLSNLNDRLSIEGFAYEPIKLGGVYWTLTAISLLKGAVNDIVHPRLNRDLETIVYDIVEGSKNADGGFGNAPGHPSSIIATHYAILTLSLLGRQDSIDKELTAKYISGLQNADGSFNCDLFGEADARHIYSSVICLSVLGALDSVDVGGIVRFLLSCQNADGGFCWYPRGESHAAAAFCCVGALSELGALHLADLDALGLWLAERQTPGGGCNGRAEKAPDICYSWWVLSALHNIGRFEWFDSEKLVGFITRAQNQEDGGIAYLPGFMGDVFHTFFALAALALIDHERFGLTQVHPVYATTPFGLRGLTGIRGNTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES3</accession>
    <name>A0A061DES3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0402680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769966.1">
        <property type="nucleotide sequence ID" value="XM_012914512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES3"/>
    <dbReference type="STRING" id="5866.A0A061DES3"/>
    <dbReference type="GeneID" id="24566321"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402680"/>
    <dbReference type="OMA" id="RGASFQI"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18095">
        <property type="entry name" value="SpoU-like_rRNA-MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="223"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="337" mass="37577" checksum="DACA0E863C504BB1" modified="2014-09-03" version="1">MIARGRLARRLRITNTVADGIRPSVFCKRSRFTAPVAAEAPTHLRLQKAAVTRPTVQLPSWLSVTDPAAPSEEVCDAVSTELSPRLRNVRPFSATQLALFKAHPVVQATPSRKNEVVKHLWRLRVNAAYRKAQDRRLVTSAGVVLHMLKHTGCLFNNIFTSDRGLVESILAAEEYRSRYSRVQLVNRSIVKYCLRGTTAAVESADTLAEAIVPKPSVPHKPRLVLALDNVRYPQNIGSIVRSAVAFNVDLVFYLKGTADPFDWKVSQITGGLQFMLPYVRGDARELKRLCKIHRLTPVVAHLEGQQVDDLEIKQGLCIILSNESHGPDPDILKFAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEU0</accession>
    <name>A0A061DEU0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770051.1">
        <property type="nucleotide sequence ID" value="XM_012914597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEU0"/>
    <dbReference type="GeneID" id="24566406"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403530"/>
    <dbReference type="OrthoDB" id="10499285at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="133" mass="14694" checksum="1A567B1BEF4C070A" modified="2014-09-03" version="1">MPPMKLDLASQIGIYRQRNLRKLAERSVHKQEGTVAKTICRPVSDLLDAVLRAGVSALQWVGSESKPGGSRQEPEGRNTTPDEMRAAKFDLDRALKALSKLKGGNNRQVNAQQRATYSTMASSRMGNQHQNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEV2</accession>
    <name>A0A061DEV2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0404130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770111.1">
        <property type="nucleotide sequence ID" value="XM_012914657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEV2"/>
    <dbReference type="STRING" id="5866.A0A061DEV2"/>
    <dbReference type="GeneID" id="24566466"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404130"/>
    <dbReference type="OMA" id="FFTVRTY"/>
    <dbReference type="OrthoDB" id="365770at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="8660" checksum="3CA3E47FD834CDA1" modified="2014-09-03" version="1">MGFSFLHLVEAVVLVFNAMGILNERRVLKPLGLDKPTNVNSIKNHISVVFFTVRTYLRAFLIIFNLLLIFLELVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZA8</accession>
    <name>A0A061CZA8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765944.1">
        <property type="nucleotide sequence ID" value="XM_012910490.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061CZA8"/>
    <dbReference type="GeneID" id="24562299"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100870"/>
    <dbReference type="OMA" id="WEITESY"/>
    <dbReference type="OrthoDB" id="366466at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1371" mass="151286" checksum="E85369B865FAE74A" modified="2014-09-03" version="1">MPSSSRGSQHSGSGYTLDSELEESPTNTPGSLSRQSYDSKLSRSSSRRSNAARGELDHEDVEALSERQQSSRSSAGSANYTKAETGTRLTMGGRSDKSSMHLASFFTNKSSRSSGGGTDRSESSRRSSARSSDEGEEYHRSRSRSSVSSRSKERSSSKSSRSSASVDVGPYSKTQVNSPVADDRIQQACSKYGLDNDSLQEILEGRHRSQRSDASLSNRDQGSENGETSPDSFRDEMLVYLLQQQLKLKAELKAQKSRGHGSHSTDGTPVRSGRSFQSDGSGRSSKGYKALEEVTPNELRSIQEGWGGDSLRDQESNAPGTPKKQGTRSNVPTLGNSGAFTLEDTYSSSGASRREGMQQQASHAGGAPMVADEPPLYARNSRTLNADEMGIQNEASSLHNEIEQIIDSLASSGMDQLSDGAMAANQNLGMRQPPFPPQYPQQFSGAGSGQFSMHSPNQPPMHNGQHPYMNSGSHSYMNSGSHSYMNSGSHSYMNSGSKSYTDNGSNPYVNNGHHSYDNSGSNSCMNRMDAPYINSGSNSYMNRVDTLYDNSGSNSYMNRMDTPYDNSGSNSYTNQMDNRFMYPEDEHYVDELPLPIKVPTKDPKPDVMDAMVMTDQTARENELHAYERLNRELEEEAFDNQGAYQTDNTRITKDGISWEITESYLKEEERRMLLEQKRAQMLKRLKEAPYAKTQTLQDHYAKWAAKKASMPKPRDGRPEERVGSSKSFDKDEAFCQVPCNVIDPVAATCGAPIFRRTRGNSRQRQSSNHSTDSKQTPPPRQADYQIPKAPRLAPIQPPMKEAPCSGDATPSRRDIYIKGSWDPHTGALRISNDLDSSQNTDKTRILDDYVDFLKQNPGNWSREPSLDETPLPPPMVRARAEDPPTMKPDIAKEVREAEPEPYTRRSVSATESIRSEKSLTLTSSSSSGSQGDLYENDEFYPPSGPLPGDFSGVGFASPAQQPKYAMGFSDPYMPPVRSASDLYSSSMAHLAVLNGARASSTMTAPVPASNPEERSHHHHYHYHCSERRHRTCPHRRRHGCRHKHRSSCSHKKHSHAHGAASDDCEHIREHRKSPCRGRSMATMTSRDFEPAEKPMPAAERQETEMTLMSPKSKSSRSSPSFFCKSPSPRLQSSPVERSGSGIRVAAPFDPCFDSSDDGKHSSHRTEDSDEAPLSFRDIITTAGRLKSTDFVKVTMYHSPNAENDVAEQQPAEAQAVLEPEVHVKPSGWCCAETTKAEETPAEQPQSDGVGLRDDATVRADSTRSSMCRAPSPTCTAPWSTSPVRYPHVFSRRVHVRTTNSPKVCVSPLAKLENGECPNLCKQPDASPLKVCYDSEAESSEQFTFRDSRPDDSKQANAPPIFKTRVLYVGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0B8</accession>
    <name>A0A061D0B8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766304.1">
        <property type="nucleotide sequence ID" value="XM_012910850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0B8"/>
    <dbReference type="GeneID" id="24562659"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104270"/>
    <dbReference type="OrthoDB" id="366440at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="506" mass="55814" checksum="EFE2B0923A888154" modified="2014-09-03" version="1">MTGSPVEHLALQSSSSIEIKNLHTSDSNLSFGYSIHSEDEEQLPSDSTNANTPQLIAKAHHADEPSSGCLHIADAAMDLDNDDHLSATVERPEPEYDLGNFVETADRYNITRKVASYCSLRELPHSSSHTSTESIEDFNIVAHQMSTGKDGTGVDVDATCMSDGSTAELAVAPKQHDADYHAQRRCAQHKCSAKVRKSPATSPRGTANKERPRNYYSKERVDITLRPVQPLIALGLPGTKGTLMMKEPALCDTTTAPTNPDGAEPKADDTSSSDQDKGAVIIDVISAAAKLKGIRGKFKYYGRRKRDCYFGGAESGPFFHKASDKDSQLEALQKLRFCRLYTPIPTQVLEGEDEVSTDIVMTGSLADHQFDPDCCDVDTSGIEVTDRAGTANTVFISKCHLTYNAVGEPCWCCCYIDFFNVFAQKRFDVDAFGYELAEALAERCKENAETLFHMLWIQQNRHSLERCIPTDASISVLQRFVQIKHAVLRVDRMGLFAAQMRQVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0G4</accession>
    <name>A0A061D0G4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0104720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766349.1">
        <property type="nucleotide sequence ID" value="XM_012910895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0G4"/>
    <dbReference type="STRING" id="5866.A0A061D0G4"/>
    <dbReference type="GeneID" id="24562704"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104720"/>
    <dbReference type="OrthoDB" id="10675672at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="580" mass="65830" checksum="68B6AAE66A10A030" modified="2014-09-03" version="1">MAVSAAENEQTYQAVSDSTDCNSHAKHNEDGNEGMLMDISEMKATVEDKMETRESLQDINEMKATVEDKMETRESLQDINEMKATVEDKMETRESLQDISEMKATVEDKMETRESLQDINEMKATVEDKMETRESLQDISEMKATVEDKMETRESLQDINEMKATVEDKMETRESLQDINEMKATVEDKMETRESLQDMREMMKLLKDMREMMKSLKDMRETMESLKDMREMMESLKDMRETKEIAETMKSLVDLLQRGLLHKYVVAPCVLKTPHPDGGAGTSPSGSGQQQLCSAPPQSQHASSQAQSVNIPETCVVKKSPNLTAHQQVVYNSLIYVPRNFKEAVDWLIAVRGDDGMKNLKALGAALYDFYAHMSGRFTEVSDLDKVIRVSREFLEQEKLKKRRSVKRILIKLNDRLRKTPDQLAKRIGSAHDTKNEKYLQKKGLTADTIAENLCCVVDACAEFLGRIKNRSHYKSAYSPQATWDASFSAHPETGVVIFVGIAPMLCASISSLNAAVFAAMLRFPPFIAYKRMQELIQALGYVEPECRAGMTASYVGDALEGFEETIIFLYELAGFWIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0X8</accession>
    <name>A0A061D0X8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0101060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765963.1">
        <property type="nucleotide sequence ID" value="XM_012910509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0X8"/>
    <dbReference type="STRING" id="5866.A0A061D0X8"/>
    <dbReference type="GeneID" id="24562318"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101060"/>
    <dbReference type="OMA" id="FLVQPRC"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006511973" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="203" mass="21743" checksum="DA17659E04668499" modified="2014-09-03" version="1">MKSFFGVTAFCAIFSLMTAFCGAADADASGSQALYTHAVKMSFAKDGEEIGDIIIGMRADVAPKTVANFLAFCNGRDIDGRTYKYEGTVLHRIIPNFMIQGGDIVNGNGTGTISIYGDRFADETFKLKHEGPGVLSMANAGPNSNGSQFFITTVKTPWLDGRHVVFGKLIEGWPVLQELEAQGTASGKTKTVVTITHCSSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D128</accession>
    <name>A0A061D128_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765983.1">
        <property type="nucleotide sequence ID" value="XM_012910529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D128"/>
    <dbReference type="GeneID" id="24562338"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101260"/>
    <dbReference type="OrthoDB" id="10350394at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28562" checksum="B2DCDD241A22FD2A" modified="2014-09-03" version="1">MVYFTLTQAPRNLKEGIDWLIAVKGDDGMKNLKSLGTAVYDFLADKPVGFTEVPALEEVKRISKEFLEQPELMHQRFVQGLVTRFNKRIGKQFIKYFRFAIPINESDYANVVVTRHLLPEKIAENLSNVVTATDLFLDDIKNPDKYKSAYSSEATWDASCSTKPEDCAAILVGISPMLFSGLLSLQRAGTAANRKWSKARKGKRLRELLGALGYKEEVCRNSISGSDVVSALRDVKERTLEILYDLCGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1B4</accession>
    <name>A0A061D1B4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766083.1">
        <property type="nucleotide sequence ID" value="XM_012910629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1B4"/>
    <dbReference type="GeneID" id="24562438"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102260"/>
    <dbReference type="OMA" id="YVYSCID"/>
    <dbReference type="OrthoDB" id="364811at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="352" mass="38488" checksum="31DAD07064B1AAEC" modified="2014-09-03" version="1">MATVLDALLHSLGELSKRSVKRSAHVWSARLGEIYNRRQNISPSQVPVIVRCIVDNHLETHPKSKALLEHFSPISIQLEGVAAADVAAICYAFSAIGQDAAAESLLRDCWHRAEAISEDLRGYRDLVRVTSLATSKQLAGGGGDVRGCAQQGGASELCERVIDDTSGKLRALQCSLNTSGVYNSVAGDLLVETVYLCNLVKRSASFFNGSNRWIDFASIDGRVRISHLLAHNHRSVLEQQIASASFQDTLAVLRHLMYMRHHQQDHIHQLFNRLCSTAGKSTRMCRSEACSILDNFIHVLRAAADARAGTPAADSTQQLLAYLTGIRRTGVLSGGHISTHRWNYPVMLPGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1D0</accession>
    <name>A0A061D1D0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766797.1">
        <property type="nucleotide sequence ID" value="XM_012911343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1D0"/>
    <dbReference type="GeneID" id="24563152"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109090"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="168" mass="18419" checksum="2CD126BC98EF13D3" modified="2014-09-03" version="1">MASVVAKVRVHEWLRGLGGEDVPVQCYGCMAYYLTRHSGKNLSDCATFGCITKCKGKELKCGCKCCKEKCREPDACKPIPPPPPPPPPALPDAQHLRATEEQSSDLQDHTEDSNLPPSPPSPQAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1G4</accession>
    <name>A0A061D1G4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766827.1">
        <property type="nucleotide sequence ID" value="XM_012911373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1G4"/>
    <dbReference type="GeneID" id="24563182"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109390"/>
    <dbReference type="OMA" id="CACAGEQ"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="200" mass="22848" checksum="DCC5118559A8D378" modified="2014-09-03" version="1">MDSSADICNVFENKVSFTDEFEVNGLRFLFKPLESYEEYLEVRPLVETLSQCPITHCRQYVDVMLRLPSYYPFLVCLVDDSSGRKRNDDTAASSSCDGPAPASGPDSSPATSHIVGYIEVYMMPHLGRLFDSRFERIIVDPKYRNMGVCQKMVATAIHFCRSVLRCNRIDMICNNPVAIHVYEKFGFELVKTNTYRKTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1G6</accession>
    <name>A0A061D1G6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766669.1">
        <property type="nucleotide sequence ID" value="XM_012911215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1G6"/>
    <dbReference type="GeneID" id="24563024"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107810"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="96" mass="11011" checksum="32D47303A846A3FA" modified="2014-09-03" version="1">MASCGSTCKCGEGDGNCCKPNCEYCKSCFSCKCNCCAHRRKGLAIIFGILFLIAIILCVVYYMKDKRIWPFHKLNDYFNRIPDIYDPYEKFPPKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1L3</accession>
    <name>A0A061D1L3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonucleoside-diphosphate reductase small subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0108310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766719.1">
        <property type="nucleotide sequence ID" value="XM_012911265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1L3"/>
    <dbReference type="STRING" id="5866.A0A061D1L3"/>
    <dbReference type="GeneID" id="24563074"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108310"/>
    <dbReference type="OMA" id="SNPFPWM"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="339" mass="39364" checksum="8290F3B591062CA7" modified="2014-09-03" version="1">MARDAECEQLSKRMKELEADEFLLVEDETRTTLFPIRYPQFWEWYKKAQASFWTAEEIDMSSDMKDWEKLTDGEMHFIKNVLAFFAASDGIVLENLALRFLRDVKLPEAKFFYSFQITVENIHSETYSLLIEQYIKNEAEKDRLFRAIDTIDAVRDKAVWAAKWMTNDNSFAERIVAYAAVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELIARDEGLHADFGCFIYKNLKHKLPEDRVQQIIMEAVAVERVFICDSLPCDLIGMNSVVMTQYIEFVADRLLQALGVPPVYKVKNPFDWMDLISVQGKTNFFEKRVGEYQKSGIMANVEEQKFATDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1L8</accession>
    <name>A0A061D1L8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766877.1">
        <property type="nucleotide sequence ID" value="XM_012911423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1L8"/>
    <dbReference type="GeneID" id="24563232"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109890"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="80" mass="8505" checksum="7681F25E22A1D875" modified="2014-09-03" version="1">MNCQLGDQWNLDDDFSANKLLSLAVERDAEGYLAYEEIADVAAHREAEDAQVEQDDGDDDGNDDGGDGLGGSGIVTSPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D237</accession>
    <name>A0A061D237_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">acylphosphatase</fullName>
            <ecNumber evidence="2 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0109860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766874.1">
        <property type="nucleotide sequence ID" value="XM_012911420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D237"/>
    <dbReference type="STRING" id="5866.A0A061D237"/>
    <dbReference type="GeneID" id="24563229"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109860"/>
    <dbReference type="OMA" id="HAIMAEN"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF3">
        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="97" mass="10878" checksum="0E46F979EF863B1E" modified="2014-09-03" version="1">MSPVFCAKFRVSGRVQGVFFRKFTKEAADRLGIKGFVRNEADGTVSGEGQSHSLSSMDDFRHFLEKVGSPNSEILSCDFKMTEKSGDLEYNSFDIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D269</accession>
    <name>A0A061D269_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766393.1">
        <property type="nucleotide sequence ID" value="XM_012910939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D269"/>
    <dbReference type="GeneID" id="24562748"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105160"/>
    <dbReference type="OMA" id="CIENNMQ"/>
    <dbReference type="OrthoDB" id="365702at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="51546" checksum="207B9489CD602396" modified="2014-09-03" version="1">MRLKGSTTYSDGDSREIEDIFSEDVKDPSMYMIISSDEDEEEHMYESTCTPIKSTSVERRTNRDHDFLSAKVCRQYRLREELYQRDLKADAILSQINQFFEQSMASLVSAGAKTPDDVNTPKDHCEQTQENVRPTESKDAKTGDSIVVQDNCNLAVEIYRDIRKRKRKQNTKYYFNEDPVLGDTITDEVGTPSAVYIPCNRTKGHKRSSAQRTRSKFVNDDQIFDVTGQSNILTPKTLNDELEGKLNKRERSNNKTFKGTQEISVTVSHTDLSVQSSFDTVLQTTPRRSVKQHRRGKNNKSVTQQMGESSTDVRNICLKFVIIDENCSVIKDERLEKVIVRHDETIGNLAAKFGKLFDLDENKHRDIKIYVDGDLQPHDIAIGSEMLEIEDGMQVDIKFPQKNAGEGLVAVSKSTQETADDALSNVVGHVASNACATEPHDWVSRALFEDVIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2J6</accession>
    <name>A0A061D2J6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0111060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766994.1">
        <property type="nucleotide sequence ID" value="XM_012911540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2J6"/>
    <dbReference type="GeneID" id="24563349"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111060"/>
    <dbReference type="OrthoDB" id="365771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595906" evidence="2">
        <location>
            <begin position="26"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="381" mass="41533" checksum="6E4B561CD24D0E1C" modified="2014-09-03" version="1">MKTVALSVTAALALCCVGVFEAGCAEETYTFPDDYAGRSSGSGSIETIHFASYTPSQHQIEFAKRSIADDESRETMKKLVEILRQSTAGQSQADTIEDYSNEFENEPVADAAYETSDRGSAVSTELGATAGSAGRYHAAQPAHDVNGNPHTAFNQISSGVQVSVNHGLINSHLHEIPEPHFEEIHAHDSHGSHAQEEPSAHRQPISGRGRHLGHVATHENALHAHPSFVAYTPSAHHDNAAHGNAHQDQHYPYHQPSHGGEFIAGHATHNHAEIGPHHAEHAPDQEAVQLVNRMCQALVRNPEYMAFCRNPVVQDIIRENPQILDEQYSIDILGQHLQPTNNDMVTDFRDGHSVSQSMRYFISKICVGPLPAACNNVALHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2M5</accession>
    <name>A0A061D2M5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L19, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0201880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767217.1">
        <property type="nucleotide sequence ID" value="XM_012911763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2M5"/>
    <dbReference type="STRING" id="5866.A0A061D2M5"/>
    <dbReference type="GeneID" id="24563572"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201880"/>
    <dbReference type="OMA" id="WGGAYNI"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="223" mass="26418" checksum="D3CDB4C8797C5BBA" modified="2014-09-03" version="1">MPSINLGDLVEVKYELSRTQQTFATFQGYCVDIRRRGLNSSFTLKNAFDGVGVTQMVPYYSPRLMNVKVMKSVSKAATAANRAARIQKPITRDYRYRFHLNVRHRFSRRRGVHKPGIRNFEIRLKNRIARLKNSYYQMRFEAGLPSYVWGGAYNINTTSRARLVRAETNRRMRIYSMDEQRLRSEKLHKRRERSKWGVYRLPGLRYLKLLDTQKQNSLTENKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2R4</accession>
    <name>A0A061D2R4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prolyl endopeptidase-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Prolylendopeptidase-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0202230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767252.1">
        <property type="nucleotide sequence ID" value="XM_012911798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2R4"/>
    <dbReference type="STRING" id="5866.A0A061D2R4"/>
    <dbReference type="GeneID" id="24563607"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202230"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051543">
        <property type="entry name" value="Serine_Peptidase_S9A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757:SF19">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757">
        <property type="entry name" value="PROTEASE FAMILY S9A OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="6">
        <location>
            <begin position="738"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="961" mass="106419" checksum="652EAC46636189EA" modified="2014-09-03" version="1">MRNPFSLYIRAFHHELCQTACCRRLFSGTSTGSQVRTVVYNTTIASYVRLMRQMDPPFTQTKQEWWTSQIEEGLMRGPRPAARRKREKGDAVATALDNYEWALEENRRDFERVSDVVRREAAKITDGMQEKLEYEVIGDHAYFVVNSSAFNHEGGRGQAGGVVEDEDRVCLVRAGLPNRRGMNRKRQPRGQPSEADEPYIIGRQQGVLDFGNIVDGRGNLVSNIRSMRVGQTRHPNAVLALVHDASNPDMGKEVHFVAINCVKKKGYHPKGGAKIRNVPKVLPDYLTGVDELHFLPRGGARDRHCARVFYTLVNEQERAWQLRVAYVCTSNGKITNDRPVYTERDPTKYVAIHKTKDGRMLIVAALSHGRTFETFCIKANATPKLYRVPLASDTKAFLEHRQNHLYAVRHVTVNDTGDMESRASLNYRKFASMDNVKAQGIDSSRYDGGCVHGKNQWHTHDTSLLWAVSKMDDRALIPNFKRSKRVEAVAARACGEIYRGGSGRWKTVATFDHRVVADIDMMYRGLVIYAMAPPSTPTILVMPFCALKSRGKGIDGRGNRNGLCEVDLPLRVGAIEPQGNSNFGATKVAIVINAPGTRDIKCYLDLDVVREASSKTDPRRGNGDSETKAASRVTEARSRNPTFQGAELRNNVVRSSLQTLTCVGDVPSTHHHVCHVATRDGTCRVPVTLIKKASNTQTRFAAADSVLSSFQNTGNKCVVYVYGAYGQCLQVNNDVEHNVLLALGYTLCFAHVRGGGEMGNSWHVDATKSEKHRGITDLADVLEFLLAKSIAQRNKLAIATTSAGGVLGGCIYNMLPGLCSCVLLKLPFLDVLDAIADPSKPLTQLELEEFGGMDDISVDEVYSYNPCSNARTKAGAKPALVIQCNAEDARAPWRHSAGFVALNGRHCSNIFMKITHGSHVDGSSQEERLQLIAERVQILEQQLGEEGRLACRGAAEISDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3E6</accession>
    <name>A0A061D3E6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RWD domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767437.1">
        <property type="nucleotide sequence ID" value="XM_012911983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3E6"/>
    <dbReference type="STRING" id="5866.A0A061D3E6"/>
    <dbReference type="GeneID" id="24563792"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204090"/>
    <dbReference type="OMA" id="SHIGEIC"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="28049" checksum="24D2B67DB3D290E6" modified="2014-09-03" version="1">MDESERAMEIEALSAIFIEGEELQIISENEVVITCDPRSQDGSHGCSMKLKFVLPEGYPAEESPSYEIVDELGITYEDKERILAVIEEVIEQNRGMPMLYPIVEAVNEQLATCATNAENGESESDNVDGEVEDGENGDETNQRDGMDTGLFLKQLCNEQDRVTKEIFDEWSKTFRLNMIKKGIWRDIDAGRNKGQMTGREIFESKSVVIDVDGMVHIQNCHWRSENENVFWNDEALYEGDCDEDALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3X6</accession>
    <name>A0A061D3X6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766943.1">
        <property type="nucleotide sequence ID" value="XM_012911489.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D3X6"/>
    <dbReference type="GeneID" id="24563298"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110550"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1404" mass="155408" checksum="EF0B24BB589805E7" modified="2014-09-03" version="1">MAAKGSVPEFTTLKQCLEFLEWLHSDRQGRLMQGLVAHRLDKLLKKMYESVDQKSVAEELSKFLTHVSNFYRKICTKPIGSYAGNKSAKDTLNYFLQCVPKLLSTIYFLRYHVDSRFSAMGGGRWADQEVGLVALHESMATDLDRYLVETVDKNKYGVIPGGFQNREVKMGHRSGYNPGSAMAADLQNILEKYSNQDKQNYFLDVYSTTVLSTFGSDTPNIANALRLVQDFCKIFEAVRDDKDFESHLYAKDRCIKLEDLKRHCAELKGPLGQLFNQKAFSFTGYAREYHKLKTQDIAKKLASWFKRNLDKVRTQLMKVQSIASSTQINNKSFRGSAVLGGQSKALAEYFNKNLLRYGFTFHGYDFNRWKTHDVLTKDWSDVIEKLNKADEGLDKLKKILDGDSCPAVKPDEDEEDKEEPVDEVLEGERVVRVPPKVEAPPVKVPEAPKEVVPEKIAETAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGGQSQAGGQSEEKRGSSPVVQAPQTHTSSDSSAGSGSPGDHGAISGQGQDGQAGDSDAGQPVGHGPQTNVSDSVATSSAAGSSSGSGGSPGRGGHVPGASNDQESQTKKLTCADGYTPIKLWHDSGTYCVKNYDYNEQQKLHEKWDDKYIKTQRNVQERIRMAEDKLRRQKEAEERRKEAEKQRMEDKEREKEEQRQLQREAMLPEIDVVFGPQKLTAFLKDAYWAALPNQMKDAMPNVSFSINTPSPRNSAYIQDQAMAALHNPEVFFLKGTEVADDGETYDVGVKGEAIGDGDSHLVLQKDVDADAEWQEVQQRKFRDDIEKQLTSSNADDAFMSGAPVESSEPVAFSPGDLSNMIALNGGAVTYFDGVDVSYDNTPVVSDVYKAEMLEAKGDVVDHSNDLVVSLMDGNYKPEDLSTTLQKQKDDENRRAVADQYVSGILTGTTTAGARGNKRLGPQQSAIFTGYTIKTPNISKTQKRIHIPTAKKALPTPMRGSPTGIGVTGNKNDPLTVYAPHSPLIAHINDTTIPANLRISNAFRSQLTGNSIFAPNRNLSPIPTEYLDPPPPGGLEIVEAYVPRKIPDPFEIDIHVPKLKSPDNDLNFDLSFDDDSTHIKTETLPDPVDPPFPAVSFNIAPPDVEQSMPPPQDFDPEIIHRPELKMCISSWATSTPTPGSTDIPETELFPAEAPRTVREMLQWLAGLRNQKHHETLKQCIEKAFSGLHKDPSQLALSINHTNILPDNVFDILQLTAMFAGSVLTAIAPRWRANVSSRFVKPKSSDQSDEPDCCALLCQLRDYAYACHHQLEFLKSQCNREKSHGGWQNCNYGSDPKKPSPLQAFLTDAYDSTFKTHLFDPCNLCHKSRIRMGFKKNDSPEKSQTGNILATILTPSCGGSDPLLTLASYLNCLTKAHGHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D403</accession>
    <name>A0A061D403_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0110790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766968.1">
        <property type="nucleotide sequence ID" value="XM_012911514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D403"/>
    <dbReference type="STRING" id="5866.A0A061D403"/>
    <dbReference type="GeneID" id="24563323"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110790"/>
    <dbReference type="OMA" id="WPVALMN"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="249" mass="29359" checksum="DAE2B64ACCB6663F" modified="2014-09-03" version="1">MKRTLDEGNSAANINQMSQSQKPETQAVLPYIHEFDEVQKQLLDIDEECANRQIEIQREYDRKKQPHFKRRQACVIYDLFNGVQEIINKIPGFWARAILHHPALSYLTTADMPVLELLEKVELDDNIDNNGSYKVTLTFGEGAREYMEPLVLTKHVRFSDNKEDVVECTEIHWRPGMNPIDVAIKARSDERCIDWSLFEWFTKDEWINRPDFGEILRRELWHAPLAYYLDTVSVDFVDDEYDMLEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D426</accession>
    <name>A0A061D426_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767682.1">
        <property type="nucleotide sequence ID" value="XM_012912228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D426"/>
    <dbReference type="GeneID" id="24564037"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206540"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="113" mass="12929" checksum="BEADBF5E583BB771" modified="2014-09-03" version="1">MAITLREFPDVECLRNTSSRNLAENVSNLVCPEKYRCNSATILRNCHSTKIRQNGRNLSCEITDANKSRICARQKAFVQKLKRVMQKKLALISVLNTIQETPRNLLALITRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4G7</accession>
    <name>A0A061D4G7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pep3/Vps18/deep orange family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0101530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766010.1">
        <property type="nucleotide sequence ID" value="XM_012910556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4G7"/>
    <dbReference type="STRING" id="5866.A0A061D4G7"/>
    <dbReference type="GeneID" id="24562365"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101530"/>
    <dbReference type="OMA" id="WIQREKW"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="6">
        <location>
            <begin position="17"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="7">
        <location>
            <begin position="859"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="959" mass="108110" checksum="FE7D4E239FF0D155" modified="2014-09-03" version="1">MPVKVYAEPRGFKAVNQRQVSSLTVSNKSVWFGLQDGRILRYTCPSSSTQDSRSTHTSAECVTLRPKAQGAASEVQRLFVDTKSFHCIACLASGHHWYSNFQSPDLVSLTSLNGCFVRSACFTEATSEDFTGSFLLGTQRGSLLEGRINYRQASFAFRTQYKLPDGEPVLDIGIIPVVYRGGRCHVLVASSTRCLYEFFGGTSFDDTFSKYSKTGANALRYEVPLAGPIGDIIVSERSDGSHDLFWANATGIVFVNVPYRVADDASSCLKFPPSVITYIMTPQHPLSSLQETKLRHVRTFLRRPAIQVPRSVVVVRDSLLLLYDDTIGVVNTIVGKQVGTLPLPHGAFGKVHWLLRDRLTGEVWLHATEGMFEVSVSAESEDAWKHYLFKGDIANALSSCKTSGQRDNVLLKSAYDLYERGKYLESARMYGQVEASYPNFENICLNFLKKHQEEAVVEYITMKLQQRNWYRYNPRFIILTVWIIEMLGYRYRDVFLTLQASRGVSGIDTGALATRCEEYRRKLFSTIGSLAHIDELAPSINFLLQTVMGCGDECVDFARIRRDSSNVVYYMINSGNVEGALRELIKMPPSDKRDALVLRFAPLMFMDAPALFEQASFSKLDPVILLPIALLPLMMRNERYLRHSLGMVERLLFSNETAHEESKRSLLWCCYILLLANLETEEPLLEVLNKNLVDFRHIDLAIALRYLKVKSSTDSRWSVPFIVLQSLCGMNEDALEMALSQNNMELAKQCAMRPSDEFTRCRLWRYILLQSSRNGEASLGSIIDTSNGLLQVHDLLHLLPEDTKLGDLSSIISRSVAEYESDLEERRQEVDHLCACIAETKSEIEMASRRCVSLPVDRNCMSCSHPLHTGHFIVFPCAHAFHRSCVATTLRSLLSGADLLELKRLHREFERRVDERSVSAYNEYLSRACVICGYPAALLASKPFIASVNAVQEDLWAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4N4</accession>
    <name>A0A061D4N4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoglutarate dehydrogenase E1 component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0206910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767719.1">
        <property type="nucleotide sequence ID" value="XM_012912265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4N4"/>
    <dbReference type="STRING" id="5866.A0A061D4N4"/>
    <dbReference type="GeneID" id="24564074"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206910"/>
    <dbReference type="OMA" id="IRIRRHN"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="545"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="907" mass="100408" checksum="EBEF98EA05FB2948" modified="2014-09-03" version="1">MQAGGIANASTAGRPSSVVSVLASSVADDAERLIMIRLAELVRAYRTHGHTQATLDPLCLPREPPFHRFNPKDVEVWLAPETYGLTEADLARTIPSGLVPGHMGSSATVAECISNLRKSYCGDFTAEFSHLPEEEQRFFVDRIESPSAMNFTKTERTEFFRSVASAVMFERFCTKAFPTVKRFGADGLESMVVSLDVLCSLAEASGVDSMLMGMSHRGRLNVLVNILKRPLDEMFAEFRGKNWYADEGSEYCGDVKYHFGYRNRRGSLRLEMLHNPSHLQFVHPVVMGQTRARQVDMGLDARKVIPVVLHGDAAFSGEGITAETVQMSRIPEYAVGGMINIVVNNQIGFTTYPAGGASTRYTTDLAKMVESPALHANAHNVEAVVLASRLAYEYRQQFGKDVFLNMVGFRKFGHNELDMPKFTNAEMYARVEKKEDVLIAYRKYLLETGVFTEAELDAVEGEIQAEFEAALKRSIEVSTIAPPPQAKEWKAPAMTSAAPVTGVELARLTELGKALNAVPEDFQLHPAIRRIFKERTKAIETGSNIDTGLAEALAYASLAQDGFRVRLVGQDTKRGTFSHRHSFVQCQKTFRLFNIFSKVPKGDQVEVYNSLLSETAAMGFEYGYGLENPRILNMWEAQFGDFANVAQAVTDEYVVSGEAKWGQQSAMCLLLPHGFDGQGPDHSSARLERYLQLSNEPEDMHDFLSLANDEHAKRVNIGVINCTRSSNLFHALRRQMLRDFHKPLIVMTGKKLLKLRGTYCSLEEFGPAHAFRPVIPAEVADGAAVDTLILCSGQVYFDLSGRVAELGVRNIAVTTVEQLCPFPVGAIKTELERFPNLKRLVWCQEEHANAGAWSYASPRIGHLLRHIGSDLRLEYVGRPPLAAPSCGDGATHVLGMQRVLAQAVPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4N7</accession>
    <name>A0A061D4N7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766095.1">
        <property type="nucleotide sequence ID" value="XM_012910641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4N7"/>
    <dbReference type="GeneID" id="24562450"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102380"/>
    <dbReference type="OrthoDB" id="365357at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="185" mass="21172" checksum="397ECC1EB6C0AA65" modified="2014-09-03" version="1">MSDREISRDSTDDEIDKLEQEVKRRLNVVGGLLKLRNAVSKEAYKGHFEQAKEAFDQISQHVARVQEKIDRELALLHQAKGVVEANRVQKLVVDEVLRQLQTSDTLRAISELRRSVEDSRTRSLSRQEDAADHAPTKNENKEGEGRSTSLRQTTERPERPTNNSKQGGGSRSYSKNRDTFNRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Q4</accession>
    <name>A0A061D4Q4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-activating enzyme E1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0102570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766115.1">
        <property type="nucleotide sequence ID" value="XM_012910661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Q4"/>
    <dbReference type="STRING" id="5866.A0A061D4Q4"/>
    <dbReference type="GeneID" id="24562470"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102570"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000002">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="9">
        <location>
            <begin position="885"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1030" mass="115530" checksum="FD2C60232E276A6D" modified="2014-09-03" version="1">MDLDGQNTGIDTDLYSRQIGTFGIEMMGKLQKLKVLIIGAKGVGTEIAKNLALMGVDTICLHDDDTVKRQDLGVNFFLRSADVGVKVVSEVCLRHLQDLNGNVNVIAHRGEITEEVIVQYDVVVCCDQKLDMLMKVSGSCRNNRLNKRIGFISADTFGMVGAIFVDFGNNFVCVDPSGKDTITAIVSGISSEEKGVVYIHTEGSMPFQSGDVVTFSEVEGMEELNSMGPVEITVKDKDSFTIGDTRGFKPYISGGIVKEIRRPKQINFISFEEAMTNPSKNNCMLTMDYSLFGRAEQLHWISMAYRMCGNDVNSVKASAQNLNAKAQSSAVEQIDEKVLSNFVRFAHLRISPLCSFVGGVVAHEVIKFTGKYHPIDQWLYCDFTLPEEVTTGNTSDVGFDSRYSDQIAIWGREVQSKIQSAKIFTVGSGALGCEFMKHFALLGCGTQNGGVVTLTDNDRIEVSNISRQFLFRKKPPEIHKRFQKHVGLPKSKVAAMAAKDINEHMRIEALEIAVGQETEDYFNDRFWEHLTVVVNALDNVKARQYVDGRCVWYEKPLLESGTLGTMGNVQVIIPHITQCYSESQDPQETSIPLCTLKHFPYQVDHTIQWARDLFEGLFTQLAHDMRKIQNNSSGKRAKNSVTSRFTEIDDIPDDKVKMIAQLVKITDNNAKEELLRIAAHLLNQYFVNNIKQLLYSFPADHLTSDGLKFWSPPKRIPEPLVFNSEEKYVNMFLVATSNILGTVIGKDVRVDANDAKAMPKVEFEEFKPVVLKLSNDKLNVEVEAPANNDKMREVLIDEIRRSNAKFNSVDFEKDDDTNFHIEFIWATANMRCRNYDIEQCDRMKAKLIAGKIIPAIATTTAMVAGLVMLEFVKTICYKKLKLEHFRNSFCCLATPVWLQSEPMPPTTTSDKEYDPIVGGAVRALPANFTTWDKVHLNLPNGTVKEIIEAIRDKFNVEIIILSAGNICIYNSFMPSHQRERLNQPVAELMEKLSKKPLPPSCSHLVMEASCTDDDDVDVVIPTIKFSFRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D520</accession>
    <name>A0A061D520_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767328.1">
        <property type="nucleotide sequence ID" value="XM_012911874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D520"/>
    <dbReference type="STRING" id="5866.A0A061D520"/>
    <dbReference type="GeneID" id="24563683"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202990"/>
    <dbReference type="OrthoDB" id="366735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="134" mass="15118" checksum="187F8614C474FF5D" modified="2014-09-03" version="1">MGFKKRDLPKTSQLGSVISSILTFCCGGSDPLLTLSSYLNCLTRRTPRTTGELVSFFHDFGIELHETFSHKLLLLGMFISNLHDLTSTSTPNVVYELAYLLLPRLHHALLVRHLLHYITSRSPMRGRVIHIAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D560</accession>
    <name>A0A061D560_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab11b protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0104180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766295.1">
        <property type="nucleotide sequence ID" value="XM_012910841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D560"/>
    <dbReference type="STRING" id="5866.A0A061D560"/>
    <dbReference type="GeneID" id="24562650"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104180"/>
    <dbReference type="OMA" id="EIYNNRM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="232" mass="25913" checksum="DFD079A2AD48B79C" modified="2014-09-03" version="1">MLQDDYDNVYKIILLGDATVGKSHLLSHYIRGTLPKQAKATIGVEFATRTVPLASGGTVKAQIWDTAGQERYRSITSAHYRRAVGALLVYDVTNRQSFYNCQKWLDELRLAAEPDIVVVLVGNKIDLTIQDPSVRQVHRDQAAMFASEWNLHLFEASAVSGQNVKDIFEFLLQEIHNLKSRADAPHGNEEATISTSESSRIDPLHVSRRRQHETVLGCLQQDSCSGGSCMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D597</accession>
    <name>A0A061D597_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768042.1">
        <property type="nucleotide sequence ID" value="XM_012912588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D597"/>
    <dbReference type="GeneID" id="24564397"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210090"/>
    <dbReference type="OMA" id="SEANTHC"/>
    <dbReference type="OrthoDB" id="365868at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="242" mass="27739" checksum="5CDDB8A0DCA13B2C" modified="2014-09-03" version="1">MQEHEAALTTPPAGLPAERLNREHHGLRIVETKPKANIQLGWEVAEDAISTRRGLRMYKPEETADKDALYRQMTGGLDPLLKYNRKKQPDIPEKTRQRLYGIPGRNIFNYDVEIRKECKTPAPNLDQCMIPKEDAKVMDTNIPRMSIAMRSSLEESLLPKEQCILRQNSKQVSSKTYESHIEPGYVTTEPPIKTARLSPFRYTTNLEAGLVPASDEPWRARRHFSEANTHCYDCTSPDQNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5A3</accession>
    <name>A0A061D5A3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="9">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0210190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="9"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768052.1">
        <property type="nucleotide sequence ID" value="XM_012912598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5A3"/>
    <dbReference type="STRING" id="5866.A0A061D5A3"/>
    <dbReference type="GeneID" id="24564407"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210190"/>
    <dbReference type="OMA" id="QRPHHDI"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="14">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR95866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="381" mass="42842" checksum="3CAE04B6A5B107E8" modified="2014-09-03" version="1">MEAKDDFWASLGSPVYVAAPMVNQSELPFRLLCRRYNTQLAFTPMLHGRIFAESDKYRALHFQTTPEDSPLIAQLCGDDAASLASAAAHLKGKVAAVDINLGCPQGIAKDGHYGAYLLDEPDLVTGIVSRITQEVGIPVTCKIRKVEKNSLQSTLNLCYSLEQSGCRALTVHGRHRSEKGQLTREADWEAIRIVKSRVRIPGEHTYLRQNECVVIANGGIETFEDVRRCLEHTGYVALRCALQVLSADAVMSSEALLEKPYLFSGRTYDHIDIMQEYLDLVRQYPNHPPCCIRGHAFKLLHQHCQRHHEIRDLLSAALSVDDFERALGELRRVVNPAWSYTHPSESWYRRHRNPVDNAPKAMPPANYEASLGEGLANFFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5G6</accession>
    <name>A0A061D5G6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766395.1">
        <property type="nucleotide sequence ID" value="XM_012910941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5G6"/>
    <dbReference type="GeneID" id="24562750"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105180"/>
    <dbReference type="OMA" id="STRHALM"/>
    <dbReference type="OrthoDB" id="366057at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="150" mass="17104" checksum="8740C9FE030AEE5C" modified="2014-09-03" version="1">MKKQTTHNVGIIRLRSGDSRMRLPDVIETSTDYVVKVEIDVSVLQNLHPRDVLEALRSSQIDDDVATIVIRGHKYHCEFITRKATTLLLGENPSSCTNITDRYLGTIFVSPVKTIISAALHTRDNWRSEHSYRKFHKSTPFGSDQETIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5J3</accession>
    <name>A0A061D5J3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Small nuclear ribonucleoprotein F, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0105430</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766420.1">
        <property type="nucleotide sequence ID" value="XM_012910966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5J3"/>
    <dbReference type="STRING" id="5866.A0A061D5J3"/>
    <dbReference type="GeneID" id="24562775"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105430"/>
    <dbReference type="OMA" id="MYISEQK"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7672" checksum="7781CF2B8E9A2542" modified="2014-09-03" version="1">MESYSPSSYIANIARQPVLVKLNDGTNFYGILSSLDDRMNLAMENTKEFCDGQLVKSYGDSFIRGNNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5K4</accession>
    <name>A0A061D5K4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0209710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768004.1">
        <property type="nucleotide sequence ID" value="XM_012912550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5K4"/>
    <dbReference type="GeneID" id="24564359"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209710"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7680" checksum="9A0088E6A2C2E7DE" modified="2014-09-03" version="1">MKQSTFLIQHNGPRKNLYNTMRSIINTPPIIYQQPFLHFPLPLVHNGHHCGSIKSKELPISITTAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5S5</accession>
    <name>A0A061D5S5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition motif (RRM)-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0205150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767543.1">
        <property type="nucleotide sequence ID" value="XM_012912089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5S5"/>
    <dbReference type="STRING" id="5866.A0A061D5S5"/>
    <dbReference type="GeneID" id="24563898"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205150"/>
    <dbReference type="OMA" id="PIRVMRS"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="228" mass="25934" checksum="610531DB464EAB69" modified="2014-09-03" version="1">MDDRSAKMEYPYTVPNNNVINRITDEEAARMGSRMAVGTKGNGRIHLRKAAGSVWNDPTLDDWPENDFRIFCGDLGNDVTDDVLANAFKKYPTFQRARVIRDRNSGKSKGYGFVSMMSAEDMLAALNEMNNKFVGNRPIRVMRSKWRDRDIDSTKNRQAAAVYQMAAENSKTLRKFKKLGKAVTGGKKANLVYEPKTFKRNKIYLSTGVANRFDNRSRVSHDHLLDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5W6</accession>
    <name>A0A061D5W6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766485.1">
        <property type="nucleotide sequence ID" value="XM_012911031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5W6"/>
    <dbReference type="GeneID" id="24562840"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106080"/>
    <dbReference type="OrthoDB" id="360567at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="838" mass="93348" checksum="52DCFD31F110A432" modified="2014-09-03" version="1">MDRHKECERVLKTAAVQQCKERGNLIRQDFVTIATVTAEDVLPVNDAGEFVRQIISDNAAVDKAVLRGACSILLDTLALIKHKKEQSSSNDNTAFDNKSTLAFVSGAIKGQPFQENSVSANLCHIVDRNGNSCFEDRDDGAVFNDFDDGFYELNVLQDDVVESSSDASASDDDQEVMNTYITSYRNRYGNQALTVLSDNGSTKKTHQGGILIDETAKIPRNLHMQQLFGVTGQTHADIVSNAFEPYYDHGIVSNPSTRENGVTHYVGGMYPPLHTYYSKDDKGRTSAVGLVSQNCLRRTFSPKKQNFADRLLQQSKQNKSGAMPFALLARDAERGNNGKDALLINETVIRHHASPIAAPIEHVAFIGKDKIRTFKCNIYTARILPNMVAQQQEVCSSLFTSEVSQGRMLSRMVQKLMRYEYVNSGTAAMWRGSTDAIAKAISNIEWGCLWQDWNYFSGGLLTEIDMQRIKQHLMLLTERGITDKTTILRNVCSEFAAHLSKTKEANVQGASNVTETMQQIVSKYIAEVLAAFDERYCDLRNIIYMDLRSINNRGFQQTVTSILESKGIDDGLKAGSHIKESVVYVDREIETKMRLELLPTHRAEAADLLSLTSVDEIVGEDIMQNPDLSGEPFLNMLSLPQHPAANARQLNITSTALDLCKKCFEGYKNGSFCLEKNKTAKGLTVLNSLVTLLKNYEKPFSGARNLRDFLGAAHWVPDEIATWILSAFYERAPSNDYIINSKGLQKLMCYILWLSIYLAGGSYTYNFTALKNVDLKTKRRLYPIFDKCVHIAGLVATSAAKSTAYTIELPLKCIPKTNTSAFGGLTNSITSYGKRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D608</accession>
    <name>A0A061D608_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767638.1">
        <property type="nucleotide sequence ID" value="XM_012912184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D608"/>
    <dbReference type="GeneID" id="24563993"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206100"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="8416" checksum="EADAACB5C6ECBCDA" modified="2014-09-03" version="1">MHCYYSTFITDDARYLMQPLTSEPLDTNSHGKASLDENKCVDLHADFRLLQHHTTANYLRIALFMNLSEQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6G1</accession>
    <name>A0A061D6G1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine synthase D (TruD) domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0300480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768329.1">
        <property type="nucleotide sequence ID" value="XM_012912875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6G1"/>
    <dbReference type="STRING" id="5866.A0A061D6G1"/>
    <dbReference type="GeneID" id="24564684"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300480"/>
    <dbReference type="OMA" id="IYVHSTQ"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="389"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="845" mass="95083" checksum="7F4F0BD53882424E" modified="2014-09-03" version="1">MDNMGDLDGASLPLLGKSRLLGMGTTMVELMMPNVYTERIEGFIKYIPEDFVVNEIDLNGRIVVARRTAHTEVAKMALEHERNRTSGEMFLKLRRAGNVMGTVKYPSNIFTEDDGRCIDALLDELVLRMSDDQSTSISIKNPPFCLLALQENENAKELRTLAHTFIRENLPFLDSEARPLNKAGNEKNLISVGNSLSDESADGSRLVIKVFPRPDCIRFIQRARVEAADTAQEVLKDMPTSGMPTLKGVVKHLDLTEYDKIPEDYKERQKIKQYLHFNIQKRDRSTHEITHMLCRTMRRSSYDIFTAGNKDRRAITTQRFCMRRAKIEDFVAAMAHPKWLDTVVVADFRYSDERLRLGDLRGNSFWVTIRGVSDVQQALLNLESLRFNGFLNYFGLQRFGSMTVGTHMVGAAMLRRDYEDVARLIINNEPAMERYLSRRAERTAAGEGAHTEEESSENPVAEPGSEERNNDSESLQMSSTHGKHAGKRRRSRNFKTTAADGEHGGNKHAMRYSADRVDGVQAEGVECNEEFEADRLVSDEMPVQSSEMGNTHEADALMKPTSHHSFIERELMNGMERNRPIEDVLKRIPANVLSIYVHAAQSLVFNHVLTERLKKYGTKPVPGDFVIKSSQLPLTTSVEGESSETATEKSDSPGASFGDVQLQTYVVCQNDTDKWSLYDVVLPLPGDNVDYPEFLRPVYQRVVSEQFGISLDMFATVIGNLPPQFKGRERCLVGVGGGYRHIVARAHGLQYHVVPEQSPNGGALKQNLSPYVCLRNQLKQSVAAQHAMQNHDINFNGDSHADYTNQKLATRSTLVVSCALPKSCYLTCALREVLSDESLERQYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6G2</accession>
    <name>A0A061D6G2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0108220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766710.1">
        <property type="nucleotide sequence ID" value="XM_012911256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6G2"/>
    <dbReference type="STRING" id="5866.A0A061D6G2"/>
    <dbReference type="GeneID" id="24563065"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108220"/>
    <dbReference type="OMA" id="KLCFVVD"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="133" mass="15006" checksum="2F7DE144168F3D87" modified="2014-09-03" version="1">MPLFTKFVEPGRLCLITYGPDAGKLCFIVDVVTNTRVLVDGAKVTGVERQQMPITWIKLTDTKITLCRGAKTGALAKAIESQDAINAFKQTPLGKRLEFAERRKNLNDFERFKLMIAHKERRRLIKKSTAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6G9</accession>
    <name>A0A061D6G9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0207670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767798.1">
        <property type="nucleotide sequence ID" value="XM_012912344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6G9"/>
    <dbReference type="STRING" id="5866.A0A061D6G9"/>
    <dbReference type="GeneID" id="24564153"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207670"/>
    <dbReference type="OMA" id="KNAVNNC"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="817" mass="89865" checksum="641F14BE8F2EF208" modified="2014-09-03" version="1">MATVGLDLGGFSSKVCVSWPGNDSIELHVNRLSNRETPTIVAYDKRIRCVFERGRLTGCRLYGEEADLRSTSLFNSSLCLLPYTVNLSEEPVLSLINARRYLFSLPVDEASTDLAFTVTFDDQQCAVQPRDVFAFFVNRLLDTVRKQLGVADPRANDQIQLSVPVPQYFTQDQHVAIYRALAAWGFGRIRLYKQSECLLRRWCDSHLPDVFTEFTSSTGQPKMHVAFLDVGFCHCTFFVAEVTKGDELEYRIVAEESNDAVGTYQMVEQLANFVCGSIKDKHGVDLQPPSRQAFNVYKACAKALKELSVVADVKIDCERVLADGDDFSTVLTRVDFEDMCDPLKGTLQGMMDRVLAHVEPGSLLAIETIGGGSRVPFVRLLATEAAKSLGATQVVRMSLDSTSATASGAVCLARADAPSLLEVAGAAVALEESEAKAALARDDVFSVVESEEFRKRSVLNEVDQYIIKTRNDARGAFSQQLQLDEVEPFLSALDDFALSAASDKGVSASACESQLNACRDKVRERCPAYVQALEEAEKAKAAEIERSAMAPDFSSVSEVNMDVTLPKATCLKRAAKNRLEGNALFSGGNIEMAAQHYVKALQYCSKVSGPDDEERAELDSLKLASNLNLAMCYIKMGTEASYRKAVSCCSQALELSPDNTKAIYRRAFAYDKLNELDNALADARLGVSKFPDAADLKQLLAVLEKKAKLQEDRVKKRDYSYLLKADRLARRLKAALFFAHTAARSQKARASAEDAGHASAGGTAVLRRWLPEPAGDLEAVVRTAYYCQTQLEQLHGEKDLNRKAEALKDTLKLLDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6I2</accession>
    <name>A0A061D6I2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial import inner membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0108420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766730.1">
        <property type="nucleotide sequence ID" value="XM_012911276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6I2"/>
    <dbReference type="STRING" id="5866.A0A061D6I2"/>
    <dbReference type="GeneID" id="24563085"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108420"/>
    <dbReference type="OMA" id="DYGFKRG"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="177" mass="19052" checksum="60C3D3BF22E1B393" modified="2014-09-03" version="1">MDDYLKVGTIQPNLDILQRPGSVGAQRSQYLAPNFSDKQLYLSGYGRHWGEKITYSVGLAYGSGMLLGGSFGLIKGIAKGGATKKLFINSLLNLCGTYGPGLGNRTACVTLLYCVINSSIKLTRTSEEYDQYVAPVAGFAAGALYKCKGRWPAFARYSLGSAAAFTAIDYALRNSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6J2</accession>
    <name>A0A061D6J2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET AND MYND DOMAIN CONTAINING protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766745.1">
        <property type="nucleotide sequence ID" value="XM_012911291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6J2"/>
    <dbReference type="STRING" id="5866.A0A061D6J2"/>
    <dbReference type="GeneID" id="24563100"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108570"/>
    <dbReference type="OMA" id="ASNDECK"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF292">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="61"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="486" mass="55043" checksum="E66F8CB0BE44E19F" modified="2014-09-03" version="1">MVSGGGSVVRRVASEEVASPTHAYVTYNAVNGQEAADASGEAVAGPMVEEIEPYSDERIMSLVEIAPAPGKGRCMYVRNAYEPGGLILVEKPLFVIVPDNNIELWNTINSLHERQLLQLSPLWHHAALITIITGTKEQLEIMRGKWVLDPDPPVSEDVYRILEATCVAQADGSFVYSNQVVVDPKLYQFLLQVWPLNAFGHSTDPNGLVIYNKISFLAHSCDATACWHHLGDDYFILRARRRLRPGDELTISYLGESDLLCPTHKRRELLYNWSFHCECPRCVIPVDSARGFLCKVCHYGRVGFYYDSGSTKMASNACTLCEYVYTDADISEYLELERAYVERIESIDPNDLCDIQQVYNHARNVFKQHWCLYKLETLLFECFKERGEADIARHYLQQRILYADTVMRRPLYCLAFMHEEYADMLVASAGLDLESEQVQEVKVNADVLMTIMDSYFRAAALLAVLSGLHHAYYYTVLVGLMQAIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6R7</accession>
    <name>A0A061D6R7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0302900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768572.1">
        <property type="nucleotide sequence ID" value="XM_012913118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6R7"/>
    <dbReference type="STRING" id="5866.A0A061D6R7"/>
    <dbReference type="GeneID" id="24564927"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302900"/>
    <dbReference type="OMA" id="NPVKYPY"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="120"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="306"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="745" mass="85215" checksum="CBEAFAB20C6EDADD" modified="2014-09-03" version="1">MLKQQQEPRMRDHHHTQLLDIAPDAFAEDLKWLLEGVDAPQALEDLEPWRNTIVKRYFEPAEEQEPSQPGPAVIDVENEAEDESEVEFRVITQLNSIISRVDLARQQWQDEVTEAFLAHEEEISEFSTDMNYCDSTIKLIEEALTKHYKSLEAASTYIKNLHTESSALSACLDNRQAFLKAVQGYLDDIAVSPSLIKAICHEPIGESYVRLLEQFQAKVHRMKTLYDGAPYPSLHPSKIQMKKLELVIVGRIYDFMRLEIAKLATPKANLQMIQNTNFLRLRPLFAYVRDTNANYANEIKNQYAKTLRKIYCHLFSSYYAALERCRRKNRYRDIGVFMKRSTKTPTGYFLLDDRDQLVINFKDDPIVPTGLELESLGFEEIFKSFLKLLVDTAFSEFVFISQFFEQGVTSMFTYIFEETMLHLRARVETLVKSSYDVVMLITLTLLFAANRQVMQNRGVTLLDETLGKLQNDLYARAMHHLKNMAKHVMSCTLQASSSTLDMWLPGAHSVNLSNLVYSVLRLKGTQDKLGITPITFDSLDHLIHVTVSALTLRGRKLSNTTKLNVFVIANCVAFLHPLQEFKESVVEFEQPLNKHIESYVSGYVGVQFENIINLVKSIKHAPESNPQNSERTTSAGEETETQDPDASDDATKIDHETVDKWRTAADEFVQSGREKFKAITAKVELHFAQEAAVERVNDAVLKAIDDIYAEFYTNLASFIDAGNRYLLENLPKSTKIAEWLTTNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6V4</accession>
    <name>A0A061D6V4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766850.1">
        <property type="nucleotide sequence ID" value="XM_012911396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6V4"/>
    <dbReference type="GeneID" id="24563205"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109620"/>
    <dbReference type="OMA" id="YNTHYEA"/>
    <dbReference type="OrthoDB" id="366327at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="442" mass="48057" checksum="FF147878AF73FCD5" modified="2014-09-03" version="1">MVGPAPPLAPKRPLLVPKTGPSTASKVTAPTTAPKVLFAPKKATVEAAKASFAQLKTPPPPKKAPLVMPKKATVKSSIVEAATAKPSAPISRRSSDASINADRQSNVVPDNTVPLLKMGSSAHKASDPQSFKSMLTSALVPSIDMAQLDGSNEVPVKPSAKSAVASNPTETTKVACLTPESNPDNSYGANQSPMSSVDKDKHISKDIEDASAKHVVPSINMDSPRTVGSTPWLDIERRINEIRALASANMPEESARTPRRNAADGSSLYGNYNTHYEAGRDWGKEVSRPLSYRMVQSLQKSKDKTQQRCSTTTPDRWNFVDGFLKPRRKPFASMSELSQHFRHISSGDQSELIKLLLACRSLEKLIEEQHGVLDMLDHDLREAREMLRLPEHLRGLCPQKVMGQPPQEEPFYPTSDIPLFIKGRVSLLPGANDVQLSVVSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6W4</accession>
    <name>A0A061D6W4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L35a, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0303450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768627.1">
        <property type="nucleotide sequence ID" value="XM_012913173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6W4"/>
    <dbReference type="STRING" id="5866.A0A061D6W4"/>
    <dbReference type="GeneID" id="24564982"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303450"/>
    <dbReference type="OMA" id="YRTNKHH"/>
    <dbReference type="OrthoDB" id="504467at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="115" mass="13379" checksum="504AB455219D7CA4" modified="2014-09-03" version="1">MTKSRKLWKRQPCRLYTRAIFMGYKRSRVNQDQKCSLLKLEGVKTRDETAFYVGKKVAYVYKSKNLKNGTRFRAIWGKIRRAHGNGGTVRASFRKNLPPCAMGSKVRVFLYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7A4</accession>
    <name>A0A061D7A4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768604.1">
        <property type="nucleotide sequence ID" value="XM_012913150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7A4"/>
    <dbReference type="GeneID" id="24564959"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303220"/>
    <dbReference type="OMA" id="WKRRINE"/>
    <dbReference type="OrthoDB" id="366303at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="427" mass="48194" checksum="F674FE8425F53646" modified="2014-09-03" version="1">MGKNACRITKSAQLLQLAKALVDSSCSRRNQFSWHPTETVGRIRCPHVGKSKRTVGAPAEYGRLNISQQGATHALRPHICIYNVRVSHDATTLCSGRLDNDRPCDVERCTPFASMYIGAPSGLYFVKRRLHLRNDRLQFGHVTTFFLKLLFGPNVNKVVYNDAPDLSCYLRHNFNVCASNILDLSYMHIAQSRGCQTATSISMIQEMLDSKAAQMRAKQRLNRVPPQCPHRLAKLHCGWADVLLEHLLAKHGHSENSWKRRINETTQHLSSEPRKQFSIRKDSSTARLGEFTPSVFKGHLEETISRVLGKRKMMIRVADDEVFTALVKSKSYVERTALLTLNAFVAAGAHSAAKQLYAIVEPEAFNQLDDLEVGDTLQVVPKQIEKGIVCLHYYHDKVCCHATRLHGDALMYNVRTGKLVPRFTPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7C5</accession>
    <name>A0A061D7C5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="6">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="6">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0210300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768063.1">
        <property type="nucleotide sequence ID" value="XM_012912609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7C5"/>
    <dbReference type="STRING" id="5866.A0A061D7C5"/>
    <dbReference type="GeneID" id="24564418"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210300"/>
    <dbReference type="OMA" id="MDDMVGG"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000029">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596045" description="Elongation factor G, mitochondrial" evidence="7">
        <location>
            <begin position="17"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="100"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="182"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="828" mass="92392" checksum="2086C35EDBC886EE" modified="2014-09-03" version="1">MLICALLLATASYAICLHHSDHQAGFQPLNGTHRIIANIRSAAGARKAFLSPLDRSSRLNAVSNSGLGQARLTEPHGGRQRFQYIQAAPADCSDMEVPLHRYRNIGIIAHIDAGKTTTTERVLYLTGVSYKIGEVHDGIGEAIMDYMPQERERGITITAAATTCFWKGGYRKFPQHRINIIDTPGHVDFTVEVERSLRVLDGAAAVFDGVAGVEPQSETVWRQANNYQIPRIAYVNKMDRPGASFEKCVKEMEEKLGATPVPVFIPVGAAATFQGVVDVIRRKFYKFDKDKDSFDYTQAPVPDDMQEELQHYRTHMLDYAAQASEELLDKYITNGDLSEEQIRSGLRIMTLANRIAPVCAGSSLKNKNIQGFLDMIVDYLPSPCEANKMCIHANKDESVASLESNSQTNAKETKEIQVTFDTNDFNLPFAALAFKISHDTQIGTQAYIRVYRGQVNVGDVVYNPRTKKGNKVQKLLFIHSNERKHLKTAHAGDIVSLVSDFAATLISQQVGVKDVITGDTLCNERDELLLESIDFPEPVISLKVEPEDPNELERMCDVFRKFMKEDPSFRMHMKPETQETIISGMGELHLDIIVDRMRREYNLAVRTGSPQVEFKETFVKAVHAEGRYVRQSGGRGQYGHVKLYIEPLEQGEGVQFRNNITCGAIPQEFIPAVESGARQQFQEGLLAHYPVTDVRVTLLDGTFHIVDSSEFAFHTATTMAVRDAGRDAGVKLLEPIMKVNVVCPLANFGTVRGDLLRRRGQVHTIKDGFGGVKEISGTVPLQEMSGYMTELRSMSQGRGFYTMQMSHYHPVPPVVQEKIVDSSLKRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7I8</accession>
    <name>A0A061D7I8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768694.1">
        <property type="nucleotide sequence ID" value="XM_012913240.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565049"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304120"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1710"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1772" mass="198547" checksum="350FAD1C5F311635" modified="2014-09-03" version="1">MAPKKLTDCPENLREAIDWLIQVRHGSGSSDGLGNLSKALKKLIDEAIATAFTSNVDPLLKLINPSCGKSDNCTSTFEEIQKLKKQVNESGNVEADRFRTLLRLIEEHKIEYEKYHYAESSREKALEGVKCKLSEIDKLRENLETFNKNPNDILTNLCTGLETFLGFNPDSKGYTGTGIVYSDLDRLCDAVMAFLHGVFDTIKSEDAVDNYNKYLPDYNKINKVIQTLEKQIGQGRNGIPNSVGQVKAWLEGYESVVKTNTQAVKDELRRLIDDLEGNHKMTINENSSLEAQLSDWKSVLHKIEVHVTQTQTKHISRLDRRLEEAIANEIKPIKDVVQQLKSVTYNAFETQVKAVDTKFETLPVELNNQIEKEAKRFKDILDGNFNEIGGKVESFRTGQLQNLMKSKDALSAALHKINGEEIGDKKSGVHKKILALLEKLRVDISNVHKTLEEKKKELDQLVITAQMQFATISRGVKEGSGYTMQADLSIEKHWKDLYTMIETIVGDVTNAGKKNPASLQDIVEAVQKYAETYGQDFGGTVKKWVPQMVGLEPMKGFLNKYVVENDGASLFSGSLKGQVHLLNEELARVVQGKIIIDLDNITVGTQPGSKTGVDGKLSEIVQYLRSYAKEVVGKHTKIVSDIEVALTGNDKFTLQPSPHKSYLESAVKATLAAVKYAAEGAAEEIETFIQKSNIVNLTQSISKVKLIGTNINPSSGVGFPGGTIDVALTTVKGAIDQLNPILQRARGTLKIGVDKLQSEVLAELENFKKEGVTGRISSKLKVVTETLEDLKAKIDREINVVVQQITDIEEDVETWINQTKEMIKSARQTAKSEVSNFNAKKQMFIRDAFEQAKSTVMSMLAKRHQAYSDSLKKLVVKQKYRIEGFIQNDRTHGLKGFLRVLYGGDYLSSNCKGSSDNLLCKLTEEIAQKSATISNASPKVNQYFNALLMYVYEDIKNLFTTPPQYPYSSQIMKVRNKLEIVLERMEKHSYDFRFVELLVQLNESLAELNPKNFGEVSYPALDVVKAGLNKFTEELDNVYVNKYSGAGDITWEETSGRGKKTNLTVDGRNCSKVCLTLISILNVSLGRLKLKCNRGWKHFQIHQDTVATVDTNSGKPLQMNNPLGPFFMRCGYNVSVFAGKQKGELRNEKECNGMGVHGILVGTDYKHVYNTDEDFEYPLQKLYDCLQDYYTVGHYASSFAKKQPCSVYEMLGWMCGLKYNPVQSNLLHSISDMLEEPATPVGGDGDLVTFDLQSFYINTYPNKATYKQLDEVINHIMSKSASILTTVLGYGDEHTTYACDFYDNSLKLYYPKSGEECLDMLLDILRRMLPPLRFLFMQCRLDQSHYGWADCYYGEDVYPLNWQCKDHEDEKANCRPRSALQSYLSDSLVGCMPHQLSAIGCKATCSTCPKGLPGMPCLTPLGFRGFSGSKRRGADLSNVLGNLFGNPLLASLFALAPKAPSTLPEHFQFALSLVYDWQKNCSHPIENGIKAAITDRSIALYEQTSDLTNALSNAYGSSQGGNHAAKHTTRPVDGGENEVKKGDLCSLAMSTACRDQLCAPYLYALCTDQYTYLAKKQCKTYLSWAVYLPWTLWNYLNSLYNAFKDIYCQDWGCRTCLRADTCRRGQHGLANDKTKVGNCHCSSIVECKGAMPTLYKYGFTFGAPAALNGQGGRKTCTNFMDQLNNVLQSKYFQTLFDRCDDILWQIRQPFTWTVIALWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVKALNKVLYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7M2</accession>
    <name>A0A061D7M2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0304460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768729.1">
        <property type="nucleotide sequence ID" value="XM_012913275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7M2"/>
    <dbReference type="STRING" id="5866.A0A061D7M2"/>
    <dbReference type="GeneID" id="24565084"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304460"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="549" mass="60095" checksum="968D411856C3D033" modified="2014-09-03" version="1">MKPQQTVLVFKPTLKKESDRKAQLATIQASRALSEVIRTTLGPRAMLKMMLDPMGGIVITNDGNAILREIDVSNPAAKSLIELSRSQDEEVGDGTTSCVILSGQMLANAEPLLKRDIHPTKIVDGYIEALEDALEVIDEIATQIDLDDEEAVKSVVQSCLETKFSSKWGNLIASLALDAVRRVKVTRPNGRSVIDIKRYAKVEKIPGGMPEDSVVLDGILVNKDVVHPSMSRRVENPRVLILDCTLEYKKGESQTIVDITDEEGWAKLLEQEETEIFNMCQNIIQTGCNVVVTEKGVSDLAQHFLSKAGISCIRRIRKTDANRLARVTGATIVNRTEEALPNDVGTECGLFEVRKIGDEYFSYFVKCKDPKACSVILRGSSKDVLNEIERNLQDAMNVCRNIMLEGKLLPGGGATEIEVACRLNAKLDSKAGLKRWSYRAAAKAFEVIPKTLAQNCGANPVRVITELTSLHSAGSVNAGLDGETGEICDTMKKQIFDTYAVKAQIYKSAIEATCMLLRIDMIVSGIGKRDEPSVGEKLAVNEEALDAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T6</accession>
    <name>A0A061D7T6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0201260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767155.1">
        <property type="nucleotide sequence ID" value="XM_012911701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7T6"/>
    <dbReference type="STRING" id="5866.A0A061D7T6"/>
    <dbReference type="GeneID" id="24563510"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201260"/>
    <dbReference type="OMA" id="XIKHESS"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="6">
        <location>
            <begin position="419"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="613" mass="67804" checksum="15159930AF657134" modified="2014-09-03" version="1">MWEKLYSSVVSVLDFNQATLSGCVDIICVRHKEVVDGPDGCSPSGECAGFFTHDIGSAAPCNDGDPELRPNERWVYRSTSFHVRFGKTKLLKSREKTVSVYVNGQLSNLTMKLGAAGEAYFDDDSGDAAAGTLSPYAHQLSDMSVLSEENGDSAGYALMDYGYYACSNSRYSVKSDDADPASQSSAPRASQGQPNTDRNSDPSHAQHESGWRTAASSKGSIGEYSRGWDELSIQKDVAGNSPDDQILQFSLCGHLLSAQDETLNRQLFESNMVDWERLNADPSLWYHPSLVARFDNRPPYYPSKIALPLLASWIVYNKPLSGEAIATLLRTTVLANSSPSPLPARSTAQDVRSNMSPPRYAGSRAFRRFRVSIRPTSEQLAALNLKMGVNNITFTVNSSWQGTKSVHAKLYLWPADARIVISDVDGTITKSDALGHIMPILGRDWSHTGVAELFTKIRSNGYRVMYLTARAIGQADYTREYLFGLTQKEKDKLPHGPLFLSPDRLLPAFKREVISRSAYMFKIPALRDIRNLFPPDHNPFYAGFGNNESDHRAYVSVGVPENRVFIINPSGIIRHVNVNYAKTYESMSDIAELMFPPCPDAQSNADDEQLQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D809</accession>
    <name>A0A061D809_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768323.1">
        <property type="nucleotide sequence ID" value="XM_012912869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D809"/>
    <dbReference type="GeneID" id="24564678"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300420"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27071" checksum="57383EB01B83BEFC" modified="2014-09-03" version="1">MVKDQVEETNSCICDTSKCPHYKDGTCYESTCTEYKSGCPPGCKGCEKRCTPGQKCKCCTPRCGCKDDCYAKDSNGTCKGKVPGGSCERCKVKCKDSDKCICYQCSCGTQCNGFLCACCYFCNPGKCKSKDTCDGYVLGKCADKCQGHGTYDDNGQPFYAKECKCTRGEDCKCYTSKHDRKCRCIFGEPQKDGNCLIKCDMCGKLCSQDSYVRLGTIVVVLVAIAVILLFVWHQYRDKLRKMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8C5</accession>
    <name>A0A061D8C5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold domain containiing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768959.1">
        <property type="nucleotide sequence ID" value="XM_012913505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8C5"/>
    <dbReference type="STRING" id="5866.A0A061D8C5"/>
    <dbReference type="GeneID" id="24565314"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306770"/>
    <dbReference type="OMA" id="CAKWHAD"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="123"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="43257" checksum="F43605970BE73C2C" modified="2014-09-03" version="1">MAAEQMTPYESRQMRRRRCRLMCLYGCLHACRLRDLVINNVAFKPPSRRGYAIDKYGTFLLKKGHGPHTGVSSTLGLYGIDLFHTFLRGARNQRISVIVMRHRPRSGDEEEDDEPRVREDRELIVFSHGNSTDIGYMFTAYVNLCKVHDVDLLAYDYSGYGLSDGSPGERVIYENIEAVYEYARRKLKVLPEHIVLYGNSLGSAPSCYLASMPEKYPIGGLVLDAPLASAIRLQVGHVAYTPKFDAFTNVEYLKTKSLYPTLIIHGTVDSVIPVQQARELAFVVEVRHAELMQKQDEQVTDLTESDDAGRLSPSDYGKRGYIELTRTPEDYLRTWWVPGAGHNNIQVDNMTTYNRNLDIFFKICRRWRNDRKLKMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F7</accession>
    <name>A0A061D8F7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768443.1">
        <property type="nucleotide sequence ID" value="XM_012912989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8F7"/>
    <dbReference type="GeneID" id="24564798"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301610"/>
    <dbReference type="OMA" id="QIEYNWQ"/>
    <dbReference type="OrthoDB" id="365639at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="174" mass="20553" checksum="7E0D07D91547E154" modified="2014-09-03" version="1">MFIDAAVNVLCRGVFPSPVQWQLQHVRNRVSISSFKQWKDLLIFKRYDGHHVWNLPQLKPQEFGFRRIRRKPPFFKVRKLSFPKVTKSYTPSHPFNRTLQIEYNWQAYSALYHEFHDALREQLPGVTINAIAKGGDTKLKVSTENGYVIFDAATDRYSNVQDVIEHCYRNMLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F9</accession>
    <name>A0A061D8F9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0306920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768974.1">
        <property type="nucleotide sequence ID" value="XM_012913520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8F9"/>
    <dbReference type="GeneID" id="24565329"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306920"/>
    <dbReference type="OrthoDB" id="367009at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="277" mass="30862" checksum="98548B65CF105275" modified="2014-09-03" version="1">MASIHDCMWRRFAYLLYLYTVIINASAVGAVGGAGDPDVAGKGEKTLAFYANDPECRTRLKSYTTLIAGVDDMKRYLAVLTSVIPKSDSSPEAKEAELRECKNLLKTIQTVIHKDKYDQLANLFAQYDSIKTALQNKGVTRERSAELNKELADLEIQFKNLETYAAALVNINFEVDHKQIIERTQALIEKHRGPKSPQIRRGGKAVLNANTPLPRTMNQQQRKTDEKPSNEMDAQHEEEITTDHIHGMKNTKDSSGHAALGIMVINTMVAIGLMAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G6</accession>
    <name>A0A061D8G6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769187.1">
        <property type="nucleotide sequence ID" value="XM_012913733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8G6"/>
    <dbReference type="GeneID" id="24565542"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309040"/>
    <dbReference type="OrthoDB" id="10501082at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="27781" checksum="E4C15F5FBA61F261" modified="2014-09-03" version="1">MFPARPDPFVLEEASIAALACSGRTLSADESLEVTPRSAESSPKVARKHADVGGNEEASPTQERLVEEPIPESDDERKDKYDDKFDDRNDDRNDDKNDDRSEDKYDDKNDDRSEDKYDDKNDDRRDDKYEDKLAPKEPVLADPHKETEADNWLDYVVDAAKGRVKRKPGTSASDQSGSALDLSKGGLVKVAKVAKRDEVATQSSDGGRLWRDRLKLRQQMLSEEDLDKPLPTRQQRMAGSDEVQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M4</accession>
    <name>A0A061D8M4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lariat-debranching enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0104090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766286.1">
        <property type="nucleotide sequence ID" value="XM_012910832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M4"/>
    <dbReference type="STRING" id="5866.A0A061D8M4"/>
    <dbReference type="GeneID" id="24562641"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104090"/>
    <dbReference type="OMA" id="TDYGDWK"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="13">
        <location>
            <begin position="229"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="384" mass="44525" checksum="0C89E2399B88BC47" modified="2014-09-03" version="1">MHVAVEGCVHGQLDLIYSKIREKEIADNIKVDLLLCCGDFQAIRNESDLEDLQCPPKYKAYHDFKDYYNGIKEAPVLTIFVGGNHEAPAFLKELYYGGWVAKNIYYMGHSGVVNVNGIRIAGLSGIYYHRDYTRGFFEQQPYDEHSKKSAYHVREYDVKKLQLIEEPIDIFLSHDWPRGIEHFGDTADLMRRKPFLTPDIQDRNLGNPHAWELLAKLKPRFWFAAHLHVKFEANVKHDFGNTYFLALDKPMPGRHYIEYLHVDPVQNIKHTNDEDVSICYDVEWLAIVALNAQKMPLNSFPSVVELNLNKPEEKDKNFIKRALMQETSEPHTVDGTALYPIPRPTSESIKEPAKQRTNLMTLLGLYDNDYFTAKRTARFKVKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Q1</accession>
    <name>A0A061D8Q1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase alpha subunit B family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0309940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769277.1">
        <property type="nucleotide sequence ID" value="XM_012913823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Q1"/>
    <dbReference type="STRING" id="5866.A0A061D8Q1"/>
    <dbReference type="GeneID" id="24565632"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309940"/>
    <dbReference type="OMA" id="HCILIGT"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="188"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="419" mass="45716" checksum="E70A131C00D5745E" modified="2014-09-03" version="1">MGAERAVAAYDDSLSKRFRLIGVPYANQYFTLSAEKLEKLRPCLVPLIKQHWAEVSLESNDTEHCTPGRYHYVNAIKDAKAQCVIIGAIYKDMKLRPSPLEEYSEQVKLSEQVAKYTSDDDRLFIEDQSIRMALHGPLLDPQKLVTGLVMAMKGAINDQGEFECEDYLMPGPPTSVPLPPTTEEKYVALVSGLNIAGPRSGHDSLLMLRDFVAGNTPMGDLSSKIVRLVIAGNGIGQCDVASLAQCDVYFAQLAAALPVDLMPGDADPSNRNLPQQPIHPCFLEHSRRYGTFQSTTNPYFFTVDGVRFLGTSGQAVKGICDYSTLSELEALQLTASARFIAPTAPDTLACHPEARVFTLEDDSEFPHVIFSGNSQEFASAETGAAGCSPRVICVPAFTKQPSVVLVSLATLQPRLIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D901</accession>
    <name>A0A061D901_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0303560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768638.1">
        <property type="nucleotide sequence ID" value="XM_012913184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564993"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303560"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2157"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1364"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="569"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1411"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1436"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2219" mass="250931" checksum="A5D93599FD7F8390" modified="2014-09-03" version="1">MAPKKLTDCPENLREAIDWLIQIRHGNGKDGDGLDELAKALQQVIDEAIDKADEYLKKKVGEADKLSAADPKRSEDIKMEIVEGNEYISKLEEFKKCLCLTGDKNILAQLCSALESFLGFDNKFRGYTGKGIVYSDLDRLCDGIMAFLHGFLESVKDDESVQTYWSEADKDVEKMKGKLKQGREGLEGFLSVVELGLRDWEHVLKERSENVQKTLHDLNSNIEDEIKVISHLKTISVKEQSLYWQTTTEGFVGISDAAENFVRDLDPGLQKKIETSITVVKEAVKRLQNAAQVRGYAKAVETLQNAFDKLPKQVEYFITANVKHTIHEHEKGVTELIEKVKGDIDAIREAFLNEHLKAAQGDLKNAVNCAKNSALTLGGLRNETIKTAIRAIENRLKDKANTVVDKDILADLKTATVQKHIGTIILSLTSTVDRSVTDGIRDLETSIGQPGNVFRNQHDSNLQKLVEEARRNLETALECTRKNAAFLGGIRNEKVKTAIETIQVKMESVHSHVNSMTDLTNLKSNFMNSEGITNITQALSISAADSVKSGLLNLSESIEGPDVAFAYHKDALQSVAEQAQKSLANIIAKVQDCLLVHGGLNNSKVKQAIDAIQNQLDRVDRDNVDTMAMLKDVERTTIQEHTQVIEKALNKHGQAEHITKDLKNLNAAFNSTDKVFTDYKNSLDKLASQTQEDLLAALVHADSYLLCTDFGLRKKIVDALQPVAASKQRTSQAKQLADDVVASLQKVKDISITFKGRIQPHFDKLEHITSGGIQHRISSLKEDADSIAWIHSYISSLLSHTFKEANEENIKADQAYKQKVQAALHSIKGHIVNLKKNAENNKLDGFLRDYEHHFSSIQLAVTDHSVYDDDKKAREKYFANLMQLFNDTISTLSAAYKNAFKSAAKTYLSGAISEIKKRVNKAESAYQSEITKLSARIMAQVEDLKTIAEQDRLASVISAISTPFEEIAAATDTKSVFSEDRTYRTQYFENLKSVIENIIKSLEIAYQKAYQSSAKSYLIGAIKAIQNKIQRTEEVYEASVRGNISSIRELIGGITEEKFTKRDTRKKLELSFEEPFRQLQQNVTLNSAFKTDTALRIQCFNDLKDLIMHNVKNLSTAYEKAYQNSAMNYLQNAIRSIKEKVGEAEQKYADAIELEVTKAENKIAGLKASMFKEKGQRGKLLTLFDQDFTTLFKAVKENSAFNDDYVARMSCFEQLQNLIKDTVETLVNAYELFDDCSTKAEYYLGKAFEDSESKNENLRSTIKDKVRNAFEQIISGVYAMCAKQKEADLISLKERVQEHKQNIRSIIVNDLNKGIKGALLLLKIWIEKKVNGLKTSPDMKTLAKTFKHLYNHLHKYVKFQHDGLEVEDDEEEVESEDDEDDLRIKNQHNTQGVHLVHNQIEISNKPYGPRKVTHMPRIPRKSIQNPSGRAGMSHNTDSTGQRSSSTQTTKNPIIDYFGTLHIHTLQLFSVLCEGRFSHKSAYRCTEFLKVLRTMHPSKFAGQSSSLLDALKSGLQYLMKEISYAYVNAYDGASYGFEWDDPSKSKFTEDAMNCAKIGITIIDALFHDLHGLFYNCSRDYKYNPIKGADNKYDFRSYIENHGYVVENLLQDQKGSRVKDILKKAFSGKNEFQSSQETNNTFFVYLENVKTPKGILGKLFSHLVEYYNVCHLRNPVPPEHPCTIFEMLVWLCGLEHNIVYSKLQICIRRLYDPGNNHQFALAQRDTISYYIYNSSTYSRKLLTAIVGTGDASTTYYACDFSNNSLNFHYPATGEECLHMLLDILRRLFPVLRFLHTQCKISAVHYGWADCQYGKSAQPCNWQCNDHSTDKFDCQSQSPLMSYLSDCLLGYLPHQLRSIGCQPKCFTCPTSQNGMPCLTPLGFREFSGSARTGSDLSGIIGEFFVNVDITSLFCLVPRPPTTLPEHFGFVSSLVNKFHGSNKANTNVIKTNFETSIKKLSMKLYGNTSAFTDAFSDAYGSADTVQHSKCVYHHLMHLSTRGICMHNNLSSAPYLFSLYTDYYRHHAPKHSDLYLSWAVYLPWQFHCYLESLLKDFQDIFCRDWGCRVCLNSNNCKRGQHGFLNPSSIGFGCQCPSIVSCKGVLPTLYRYGLTYDDAEELNSKKKTCFDFRTQLSNVLHSEYFSKLFDECDKFLWEIRQPFSYLLLALWLLSLLYLIHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVKALNKVLYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D994</accession>
    <name>A0A061D994_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767670.1">
        <property type="nucleotide sequence ID" value="XM_012912216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D994"/>
    <dbReference type="STRING" id="5866.A0A061D994"/>
    <dbReference type="GeneID" id="24564025"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206420"/>
    <dbReference type="OMA" id="RCLKNNY"/>
    <dbReference type="OrthoDB" id="427429at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="22262" checksum="C780056E92ACC712" modified="2014-09-03" version="1">MASDDAVRSEIASIDSRLKQWFLFRRVQAERALSIKKLLEEHNFIGLACNNKNAGVVDRVMWSDIVNGRPELEDSLSVNAREMKADMYMDIFTQSCDLDNACRLPGMRRRFAINLRAGSKYFQCLQEHFSLKSADRSQRCGESFTAFDSCRKMLQLQQNSHLQEALKRQQLLDDEAKALFQKRMELMKQLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A8</accession>
    <name>A0A061D9A8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0304750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768758.1">
        <property type="nucleotide sequence ID" value="XM_012913304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A8"/>
    <dbReference type="STRING" id="5866.A0A061D9A8"/>
    <dbReference type="GeneID" id="24565113"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304750"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="615"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="928" mass="101226" checksum="844310DF944AF70C" modified="2014-09-03" version="1">MYGGGRDGGCSGGCRSGGDLGTENPDSAPAGDAADPDVTIGAQCYRCSTRRATLLTRKASCRDCFVEVLRRNFASNLRTRCIKRVERAQSMIMLVGGDAFSTSMLHLLLDRNKRRYLRVSQIPEDSDVASRIFASDDLSVESVLSLDFHVGTVGSFAERSEAFFKHVTAVVNGVGNSSEACQPLPAVDTASERLLLGGVRLSHLPICYYLHEGATSCDQRCDALKGSLTRMYDGLLCDELAYSLDLLSTLNLRAYIQRRGLTGALVCACDTQEVIARRVMMLTCLGAGDRVAFRSAFVDDHSLAECGRIIRPMKAFSSKEVALYHRLSGLPALPSLDLYWHGSPQASILGCVNALISTVTSAHSSTLHNICNVVEKLVPDFPDRVSVCRVCGGAMYPSDAKGWSEELRSATRASLSTLCDSDYESFVDVLAFWEVFRLLLKADVLMSSCVKAFSGTRACGTRVDREFDVLLERGVAKGKTLFKDVYLVSQLLNHYVNPHKRVVPGTPSTAACAEGHNSDDDVGREHHALRNSDYPRSSAAGNGRASDSPVCGTCGVGALCHAATCATNYGVAPASKRDCSLADWDIFTKLLSGGDSRPRMMPLYNKIPFLSLGNFVFFYRINEGSSGKVHVGFHKSHRRTYALKVISKSQFNCDRALFRRLKDEMSLVTALGHPNIVRTFELLETVSTIVIAMEYCDGGDMIGLIKEYSPMAEPMARAIFRMVVAGVHYLHSSDICHRDIKPENIFLKRVAPRSFGQVASISGKGSHAVGAYEPHAIQYGMMPYIVKIGDFGAATRINDNRALLETVGTMSYAAPEVLGCGGVTGYNGKSADIWSLGVLLYAMLFGELPWHNEDFGLREAVKQILDKPLTFPCQTSSTSRDLMSSMLRIEPADRPTIEGVMAHQWLAEGNVDAPLVLKKIRPTLSKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9G3</accession>
    <name>A0A061D9G3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0106590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766536.1">
        <property type="nucleotide sequence ID" value="XM_012911082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9G3"/>
    <dbReference type="GeneID" id="24562891"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106590"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595935" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="821"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="952" mass="107926" checksum="D699C91F4BBB37F3" modified="2014-09-03" version="1">MKHLLALCSTILLSGVIIDAFHCDFYEEHELIRGDSLVVCEVDIGHDNFATIICPRQVNNADYTIHPRSRPDTGNQIETYVSDNWKLRSVPLSDVIVTEVPHSFAWMETTLSCATLYLTLKDYYISAITEHRFTFICGPRDLVMSDALQRHLNSLDGTIQTQEHPNSASAALEDEIKKIVNGLGIVFMYRGHKHLPLQGCGTRPSPLFDPDMEVTVDRVTGTRSCVANPMSKSRIGFLCEGRIEPHDCMISLIDENGGVVTAPRPFPYWSFNYNMPWVVGNYFYKFPLDPFQGECRCVDPRTGQVKAKIEIRSKMDYVCDIASKIFRNRFRPISGPWCSVVLHPGSKLTIKVPMQPVISVYIDEGVSGVPFSQLPSIYEYETAFLPKDLTTLRQLISLRGADIYDEVFYYRALAGDALELDASQISRGEVTLKYHSDKPLALRSGLNSFYYNWTLISNNDNIPDRIRATINVSFAFNHEYTKVGCDRGQRHVFDQQLSRKYCTNKVMSNDIGSIYECALHLWRDEWRAGINCSPDEELLPKNCNSTAYDLSFDRIARLPVYLRSATHHIRGFQVFDFEYRRDIPIKVACICVDQRGYEKSRLVLESYEKRRHNFEVSRGTRFNKIFAFMSPPWRKVGMLLEEPTSTRLVVLHNISKKTVNLRVGTKLVLRCTLGTALQDGANDTITPTVWLPEMHNEFHYIVIRTSQGSTLIRKAHRDSVATTFGGLEVIHQEIERGRAYEQLVMKLNTGAIAISRDPVHTERVPMRFVCGKAPLLSDSSAVSDVASPSASSARSTTNITELAEKYTWNIVKVNVETTDPYMQGCGVTYESDELFKPETPQLYDADGQPQFGCKIDIQAAKEAAFYCPPPYLLDPPNCFYQVSVNGEVKNVSDVSTSLVDVPSRHFVILRFDSELIGPRETLRETPPLECRCVTIKGAILSTIRIENYYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9J9</accession>
    <name>A0A061D9J9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768848.1">
        <property type="nucleotide sequence ID" value="XM_012913394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9J9"/>
    <dbReference type="GeneID" id="24565203"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305660"/>
    <dbReference type="OMA" id="IDMSQFK"/>
    <dbReference type="OrthoDB" id="361216at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="445" mass="51354" checksum="115268C7668BA534" modified="2014-09-03" version="1">MVCIPVYCIAFLGTHPQPDRLLLPQWQQAEARGYIHGRSALRTGSNSALYYATGHSRGLHERADPPETESSDIRVTEWDAGRHKSFRCAGVASPDSVFREPLPGEAITLPNPSATTGEYLLDREIIHRVAELRTFLEDIEVSRGKRSQLREIERGLNSGEYEIRQVTKEEADRLTAAANAGPDVESQDTVDDTGMPETPMEINEITLEPIKEHMYEENMLEEVLGKAFSVYRKNRDQASIQRLEVIASEIAPIADKVRKERAEEIIVRLVNCYVDGSENIDDVLYKLHKQKQLNKYLMQRFDELIKLASKKFRLSDEHPALSEQFLRTLKDRVAAEVLTSARGTRKWVRILAECFRYDNCVDYERVLKENLRKIEDIEDFRDWLLDGIEYCRDKGRMEERIEAMETIESIVVGLHPVWTPQDNYIETEDRPYDHPIIYEDDDVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9V9</accession>
    <name>A0A061D9V9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HCNGP-like family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768943.1">
        <property type="nucleotide sequence ID" value="XM_012913489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9V9"/>
    <dbReference type="STRING" id="5866.A0A061D9V9"/>
    <dbReference type="GeneID" id="24565298"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306610"/>
    <dbReference type="OMA" id="QRGCTIN"/>
    <dbReference type="OrthoDB" id="366313at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="115" mass="12866" checksum="041BFBB0CCB2DD8A" modified="2014-09-03" version="1">MNQTHSADVPEVADVEVPQALKENIEHLKQLHQRGCTINNNIEQSKVMKVFNIEGHCSNYSKHVYDPDYYVALARETEPETQQPRKDSQTCGQNAKAEAANAAEARGRPSGWSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9W6</accession>
    <name>A0A061D9W6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769692.1">
        <property type="nucleotide sequence ID" value="XM_012914238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566047"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400020"/>
    <dbReference type="OrthoDB" id="10509842at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1680"/>
            <end position="1703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1742" mass="194057" checksum="12349E28D1D6A505" modified="2014-09-03" version="1">MAFLSGVLEAVKNENEVTTYYSKMDKTLEKIKDSMHKTGGLSAAVEAVSEALGEWDGELDKKTSALKKSLEYLKTEKFNNMHDSLNKLNAVYGDSLSKVPVLLDACIADAGWISGAYDAAENEYENLDPTLRDKLKDALYKIKLQVKSFEAAAANTELKDVVDLAGSELLNLKQKVDERIDERMNDVKIRLGHEFKVQIHDPLNAVKKTLTSVDTDLKKWIDRATEIAKYGIEQSKAILKEVTEQSGTKKAGADAEKWRNVEKAALQLKQKAQKLYDAASTAKKSVERLVPEALSDVLKLDRAVRTGLKTTKDKIKGALRKYIKEQLLGTIMKQVKSIEGEREEEGLQGIMTKVAEYAKKFQIKGLNKGSFGEIVQEWVDDSLGEEPVKGWLTSYFEQRSRFNPPYDEWDSSGRDNEERTRKLAGIIVRQLENQISHAVSMAAHFTIEGSIQAYVDAVQTGCNEFAKNLGERIKSQTKNRLLASTIAGNIERAPDGLVMNGNTTSDQHLTFAVDAILHQLVGMAMKAGEAIDSFTVDATKMSTSVNDALKVVRSLWSNIDQATRESGIGVNAIYVDDVTEPYDLTQSVEGILLGILRNDFGLDSDGDGKVDTLVVKNFEDYDGLIKQATVPRITNDKFLGGDSTEGSLCNKIGEIKREVAGTHLIDVESGSTLDSGDRTDSTKFYSDSFGNMLTEVESRLADLMSTIKNLAENSNISEERDQRKGVKNYFEELQKMIQTEFGSEDNKHLDKIKERIEGILNTNSDGNLKDIVSKATQFKTEVIDKEAAAAIKSIKDFVDKQVADKIKNIQGQARTLYHSKISGIFKTMKTKVENYISNVSEITGEDSRTGVKGLLRKVMDHDRKGNDDTNMLKKLKNNASVKSLSSPLKAFLRPILTHVETEVKTADSTSSNKQENECSNKVNHIHSRVSALLRHFSNGNSKYNFDDTFVTSLLNLKSSLADLSAPRFSGYEHPLLLDSLKDGLMRLCEELDKSYVNTYSGQTIKWEEESNTDKTYCAKILVTIMKIFGDDLALLKHECENGWKESKISLLSQSGRYNHLGNFLRNCGYVVTKKDGSQNGELQCSAKMIGKSIVNKFGITVVSRYDSRLLMETLKLLVDHISDYYETCHLGTWQSKTYPSSVYDMLRWLSGFTHNGVYQALSFNGFEELFEKPEEDDTITLEADGITGTNLNALSLSAYPHDIKPSNLTAALTDVCNHSHAVLTTILGHGHGEGVYACEFDTNSAGLVYPADFNTMVCMIRDIINRLYGQLQFLYQQCKYDTALGGWLDCEYGQCVGGASWRCNVDQCVNLTCNQKGGQRANQNGNQKADQRCQEHPKCGVKSPLQSFLEDKLPGFLPHNLKSERGKLECSLKSHGNLPCITPMGFSGISQMASHRATGQRIVDVLAGYCGTHTSPLTRICGLFNCILPSAPKTLSDMFGFYYSFLYEWDQKSNRNNKRIENRETAFKSKVSEADFENRSTKLDITSMFGSTDHKSKTVETSHLTGDLYSLVCCNPSTNSAQPCGAYLRPLCYDTCTMFSKEHADKYLSWIVYLTETFYTALQKLLEDCRKTCGADARKCKIGKCKKDCGTKEHPLAPSANHNGSCGSIVECGYIRPTFFRYGFTHDNVASLSGVSGDSHKRTCTDFCAALRIVTKEGNALYDIVNKTIPEFLWTIRQKFFWTTVALWSLSLLYLICVMVGRLDVLHIRSHLRSPSSHRIAAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9W9</accession>
    <name>A0A061D9W9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD domain, G-beta repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0311960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769479.1">
        <property type="nucleotide sequence ID" value="XM_012914025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9W9"/>
    <dbReference type="STRING" id="5866.A0A061D9W9"/>
    <dbReference type="GeneID" id="24565834"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311960"/>
    <dbReference type="OMA" id="WENHESI"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="67244" checksum="5C2C8FFA7AFB8903" modified="2014-09-03" version="1">MLFDRRRRFRQDYIEQRCARCISVCNSYGLFNLPCRNQNRVEISTSGEFLLCSSRSCFCVIHVPSEIYSDRSVRRRGEEFTPCSCNASSASCPSPSPCEVSLTKPFTYKSKCNDCVWYTVDDGIFLSAGDSMVNVWDLNVLDIAYTFGLKLSTVKRLAVEKSNSTNPLIAAGLACGSIATCDMRAGTTFNYSNVKVNAEVTALSFQPHNQYLLVAGYEDTSVCVWDLRRHNRPLVSLGNRGSSDILSIVHGCSVAYGENGGALSKPRELPIALSQDFENEDQIWSYVMGTTKGPSIKAQASREGPLSPAVSAKQSEADSVLGIKIGAGPSLPLDRPPPKTKRLRSTVSVTDLLMGMDSSAATSTSSSSAASRVPQRRTRGPAGSSLMAKYKLVDHNRRLYSGPDSTARPEAQPSDAGPSPVRPPSTARGPKTPKFKERGMPTAIECSPEGNFLFVARHKGHVEQYDGKNYRAINQFDIDSLTKPYQTGSPKSYAQRMQLHSIANGDYLLFNVREQLAVLDVRKGALLNVVALQWENHESIVDAGASNASDTVQMAQKYVTDFAAMRSRQDVYAINERGELFVLHPDKRVIFRTHEEGRQRQPNGPEDRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Z8</accession>
    <name>A0A061D9Z8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766756.1">
        <property type="nucleotide sequence ID" value="XM_012911302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Z8"/>
    <dbReference type="GeneID" id="24563111"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108680"/>
    <dbReference type="OMA" id="INIYVEC"/>
    <dbReference type="OrthoDB" id="10589301at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="554" mass="60767" checksum="F96D90C8FB794B47" modified="2014-09-03" version="1">MLPVLATLAAANDVLDEAYAVSLNASNAFGAIEGMYIADSDFKFDQNVHEYKVKVDSCCDYIELLFRVNSWTRARYATEKSDVAQNERSGGSEGATSLIDRIGASVWALFGKQTSHEGDEGMSVPQVDENASKEEDVAPPVKDMGAVVGGTDDLDEVEVRIAINGQQIDPADDGYVMIPIRCGTTSNFSVEVTSLREYQPAQTAHYFLAVEVPGGGKNYLEALEITRSDGAQARVYPALSKAYRSYTVTGSHLQGDQFTIYAECRYGLPSIDGQEAASNVATIELKDEHVNRYVKITCGEVHKDEGDEVVEETVHTVTFATFAGEGVPPPITILPLFDSKKCEAMADTPDGNGLIVCADSTHRFSPLIVETDPNYTYVIPTSYVVDGYVKEVHEHDEEFIRVRTGVVTPVFDMSEGIVIHGMSDHEFKTFVVTSRAAGKRATDMQQTIVAALIVVAYWASILTTVLPHIVRVQFGVIFETVPVTGEPLLYLAQVICAGADEKTSKICSRFIMLPSKRYSTKSPLQMLFQFYVSGPECETLICRRGASRFYYCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA43</accession>
    <name>A0A061DA43_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767960.1">
        <property type="nucleotide sequence ID" value="XM_012912506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA43"/>
    <dbReference type="GeneID" id="24564315"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209270"/>
    <dbReference type="OrthoDB" id="10659098at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600190" evidence="2">
        <location>
            <begin position="26"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="204" mass="21878" checksum="463154DBC8D10360" modified="2014-09-03" version="1">MKVNFGAVFCTLFFLFCSIVLNVQANEEPLPADNVPAEVAVESEPQPIQEVATDVETEEAAPQEEEKSEESAAQEEEKSEEPATQEEEKSEEPAAVAPEKSQEPAQVRFDKKVGAFFGNLFSKVKNDSNVKRMVQYVTDVSATVANTVGTVSEKVTATVASTMNAIPGARASTKGSVKENTKASTKENTKASTKANTRGSVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA77</accession>
    <name>A0A061DA77_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0307660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769048.1">
        <property type="nucleotide sequence ID" value="XM_012913594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA77"/>
    <dbReference type="GeneID" id="24565403"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307660"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9676" checksum="4373441544B9F18A" modified="2014-09-03" version="1">MRVVDWLHCRGWTDKVLSEFHTPQITLAFTYVCLKTSYYLYTHADGRYAVKFGTEGTMEKTSEPKYDPKQMVIKYTKRKTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA90</accession>
    <name>A0A061DA90_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoplasmin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769649.1">
        <property type="nucleotide sequence ID" value="XM_012914195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA90"/>
    <dbReference type="GeneID" id="24566004"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313650"/>
    <dbReference type="OMA" id="VHVVGYF"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="138" mass="14997" checksum="ECB9E7E1C78B41BB" modified="2014-09-03" version="1">MLFGAVIAPGSSVTPKNDLANIVHLSQVCLNDPKSNEKTYVQLVDGNKTFNICALQKDVREHATVDVFFSTVGGIKLTTKGGKNEVHVVGYFEPEEESYVSDSDDEDMDDEEGGDDEEGSEDEEPAGKRKNTGKGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD6</accession>
    <name>A0A061DAD6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0209970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768030.1">
        <property type="nucleotide sequence ID" value="XM_012912576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD6"/>
    <dbReference type="GeneID" id="24564385"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209970"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60371" checksum="820BFD8F64673463" modified="2014-09-03" version="1">MEAMGVGGDSEVGGKEPVEGAESTKVDRIKADYGTFGQVLYHVVSFTEGYEQQVLYLCMRIFESTMSFTKSQLTVLMTVSIMSRLCFSLVWGLLADAFETNLVMAAGLLFMGIASILLSATSRFSSQKIISDEDDDESGNSSTFTRIHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYLWISVGIAIVFAMHTERVLITPYGSMDKFINQISGAFKAVFTNWSAFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDMKVGIAILVTTIGGAAGTAAGGIVIDKITGMHKKYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIPDRYQASASAIIQCISGISVSVSFVEIFAYVSEKLHGYAPSTQAIDDMDAALKDNNTEALRKSTMYMIVIGSLLNIACYGALFATYEEDKKKIEKENVEVWKERKVIQERRDEMKKKVEEVEVTLEQLLRDGTSPDGLYLPGIEGDMAEFEGSRGSTRNDDELLTDDGIRELIKQGERTFDLESRVSMLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAE0</accession>
    <name>A0A061DAE0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.79</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0210020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768035.1">
        <property type="nucleotide sequence ID" value="XM_012912581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAE0"/>
    <dbReference type="STRING" id="5866.A0A061DAE0"/>
    <dbReference type="GeneID" id="24564390"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210020"/>
    <dbReference type="OMA" id="WKQHTEI"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="12">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="13">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="321" mass="36436" checksum="0581A4B7E73B0FCB" modified="2014-09-03" version="1">MANTRFAYVRQFEQETTLMPDCWPLIRVDGRGFTGFSKVHDFRKPNEPLALGVINAAAAHVMAQFDDIVLAYGHSDEYRKILSSVVSAFSAAYCFHWSAFYPNRPLKTLPTFDGRIVLYPRFEHVVDYFSWRHADCHINNQYNICFWCLVGDGKSPDEAYKWLKHTQKGEKNEYIFKSRGINYNNLPRIFRKGTTLVRLADPETKDDTPRNDAQRDESLNNVEGSEISHSTEMPAPPKAGEADDVIAPIIAEEELLAISHKLEAICSAFRIGVLHCDNINDEFWKAVAPSYLDSGAQNTRDRISTLSPLSRENIALLNTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAE7</accession>
    <name>A0A061DAE7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0401680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769862.1">
        <property type="nucleotide sequence ID" value="XM_012914408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAE7"/>
    <dbReference type="STRING" id="5866.A0A061DAE7"/>
    <dbReference type="GeneID" id="24566217"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401680"/>
    <dbReference type="OMA" id="YHNKMHG"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="443"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="516"/>
            <end position="520"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="789" mass="89770" checksum="025E1E334CE34528" modified="2014-09-03" version="1">MGGVDGVNPSLLAHDESSSCCATFIGPRDFSHIVDPDTFETDVRDAMANMPHFLTLYSKFDNVTAIDCLRSRVRENSAHIFRPWWYALAFKNPCLERLFALNVSYRASRSILANCLIIPIMAFVRSLMKTLMKRNVINGQDFTPLLHYFTVAVILSAVLLTLPTLMLQNKVKHQTETMCYATYSLMLLLWGVLHYLFRDLVYQMEGAPSERWMMELLTWISLLLFGLGFIAILFNVMKLRCCIGQYVLVFHLICHFIATITILSKHSQDILWFDGLVRLLMYITFTAFSYWLLYTSEFEMRIRFLIWLSTYLSRNVMGTSCTNVNQFVTAAERLHDGLQECKDMLLAIRSEGDLRSADSKQRMSKIGETLEACMQQLRSGDNLYGLSYGDLEVRDEQLEVIDAYLWSTKDRFSSQLTTLRGSADTNYVSRSSLSFPVYSAPSPPLQITPFEDVAYNVLVSDWNFDVLNHFATTDQAFLSIGCGMLYQFEMLHNVDRTTIVSFLSRLESFYLDVPYHNKMHGAMVAQKLLCLANYIHMLEHLNPLDEALLIVSALAHDVGHPARNNSFFVRTQHPVAQLYNDIAVLENYHAANTFRILSTAGCNVFADFDYEYVRSQIIGLILATDTVDNFQMISQFVLMRSSEEFTFEDLKTRMLTSKMLIKAADVAAPTMPWAISQEWVSRLLGEFYAQGAEEAALGLPISALCDRTHHQQAAKSQAAFLKIVVSPLYRSILPLGSVELDQIMRQVESNIERWTGMDTAGDTIHCIECDDAKANLDVSFVLDYLSHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAJ0</accession>
    <name>A0A061DAJ0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="6">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0309000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769183.1">
        <property type="nucleotide sequence ID" value="XM_012913729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAJ0"/>
    <dbReference type="STRING" id="5866.A0A061DAJ0"/>
    <dbReference type="GeneID" id="24565538"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309000"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="7">
        <location>
            <begin position="154"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="31265" checksum="E8F7C8A30FF66AF9" modified="2014-09-03" version="1">MSDPRFHHNSCCRKVLVDFSYIGTGFHPNTVEGHLFAAFAKAHIAANVLNNGYERCGRTDTGVHALHNYCSFFMDPCFPEDPSATTAPDSNERRVCYRINTFVKAVNKHLPRSIRVNSVQRVADDFSSRHNCVRRTYKYFFQLGAMNLPLMQEASQHFVGSHNFRQFCKQDNRNPKDPNRTIYSFTVERYSDLLCVATVRCMVGALFLVGEGSISASKIAELLQRPDEPKFQYKMASPHGLILVDCNFDMPTVPRPELLDDAIQTLGPMSLLAKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK2</accession>
    <name>A0A061DAK2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAJOR FACILITATOR SUPERFAMILY MEMBER protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0210790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768115.1">
        <property type="nucleotide sequence ID" value="XM_012912661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAK2"/>
    <dbReference type="GeneID" id="24564470"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210790"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="489" mass="53018" checksum="4C86ECC77C875973" modified="2014-09-03" version="1">MATEDQGVATRKTDYTALGKALYYLISFIEGYDQQVLSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCLIWGLLADLYKSKHVLGAGLLVMGVASIFLSSASHYKVIVFLRFLHGFGFACVYPVQQKIVADSTSSDDEKKPQGSTGAAGPTGLVGQTGSAESKAASKIFTGLQALNCIGRLLCAVITTLIARKVLLGYYGWRTSYVVLGYLWIFFAIAIVFGMNKNGDDVPKSQQFQKLISDAFSEAFTKPTTWLLILTIFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSVAGGECIKKIVALSEDYGELASGIAVMVVRLLVCLLFFLGKAPSGKLLWYHYVELATLGGTLVTLGGVDRAMLKKSIEDKHQATASAMVRTISGISSSIILFQVCAYLTEKVFGYVPSRESFETMATEIKEKNAEALRKSMMYIILAGTLLNVLCYAALFATYPKTRQEVEKKNKTSSTLEQKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAY5</accession>
    <name>A0A061DAY5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0403090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770007.1">
        <property type="nucleotide sequence ID" value="XM_012914553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAY5"/>
    <dbReference type="GeneID" id="24566362"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403090"/>
    <dbReference type="OMA" id="RIREMPM"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595966" evidence="5">
        <location>
            <begin position="26"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="236" mass="27697" checksum="4C4EDE1EE1E6379B" modified="2014-09-03" version="1">MLHVFRSLLPVRLFGAAGWLPGGAATSIGPEPRLFSGLRNKNAKIKNPYYRKKGIWEWRRKLIFRLNRARYRRQFIVPKVIDPEEAGVKSKHSANVWEFTIDGLPIGLKRLKLYTKLLTHLHLQDAIDWLYAMPNVRTNRILNALSDAQKKIYEQYNGDPSRLYIQNMIINYKPPMKQIKYHACRNFGIMSTWRNSIVYRIREMPMNEFYQKIFILGRVSGQQPGVYLACLCYFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBC4</accession>
    <name>A0A061DBC4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MACROPHAGE ERYTHROBLAST ATTACHER-RELATED, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0311750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769458.1">
        <property type="nucleotide sequence ID" value="XM_012914004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBC4"/>
    <dbReference type="STRING" id="5866.A0A061DBC4"/>
    <dbReference type="GeneID" id="24565813"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311750"/>
    <dbReference type="OMA" id="ANHETAR"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="535" mass="60093" checksum="1CCDD2344F82D535" modified="2014-09-03" version="1">MGVKLSNFKAFVTPILMNAEAEVTDADNSATERDEPIRRPRRPLYTPRSPQCSNDVTDGADEAKNDTGLIKDGHLSELDRSLIAVPYEVGLSNMRELEHLMEKELLLIASYLSKRLVLLESHDIVLEKLQRALERLQRLDSSLRRIDASLETVTSQLSARIDTFHTESSLGTGKVDNKFCFDDYRQRVAWVVSEYLLRRGYLSAATPYVAQEQLNMLVDTDLHATVDRIYRELLDRQLSGALEWAEANYETLVKLDSTLLEDIKVQQVIMRLQDEDVTGAISLLKSFGSAMLERCEDSRKLFSAIVLLKVTHQRRQGNVEPVDSQDPDQVPGSTEMGDRTDDNSSQDMHEQNAPATPTQSNEDPETDSDDTTPQLICIYCDETVNSECEICNHYTDLTSPDRWDSLAAEFYRCIVSIYNLGQQTLLENLMHTGFCAIKSTSCADHRNATCPACLPEWRQYVDKVPTTTKLDSVLVCPVTGDVMGYDNAPFTSPGGCVISEHGLNTLIRSGDGKQVECPQTRLMVPKEDFTKLFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBK4</accession>
    <name>A0A061DBK4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Triose phosphate/phosphate translocator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0405750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770277.1">
        <property type="nucleotide sequence ID" value="XM_012914823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBK4"/>
    <dbReference type="GeneID" id="24566632"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405750"/>
    <dbReference type="OMA" id="MFATWYL"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="51"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR98091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="41604" checksum="3B3C76F5E1163CCA" modified="2014-09-03" version="1">MSDSPADNAKIVVVDTTEGQQSPETSKWKAWLEDHDKLICALRSFNWRLVFGVCMWYTLNCVYVVQQKIFLNAIPLHVTLSGVQMILSSIFALIVVGLKLRPAPIITNLKKAMQVFIPIGLCHLLVHYGAVISMGLGAVSFTQVIKSAEPVTTAILSMIILREFHSVFTYLALVPVVAGVSLASVKELDFSIGAFLFALLSNVGSSLRSIFAKVTMDNKIDIGENLTPSNIYMILTVISGVLSIPIVLGAEAYKWKSVWLTHTAEMSAGKQAELLFHAFSSAVCYYLYNDFAFYCLGQMNQVTHSVTNTLKRVLVIVASIIIFRNTVTPLGYVGMAMAVLGAFWYSLVKQGVFSRKPKEAEQVNDREEDQTASEQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR0</accession>
    <name>A0A061DBR0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769583.1">
        <property type="nucleotide sequence ID" value="XM_012914129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR0"/>
    <dbReference type="GeneID" id="24565938"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313000"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="317" mass="35655" checksum="E999289BB04CC966" modified="2014-09-03" version="1">MRDNENLTKDLDEARKLCTKVNEDIARLKEEVDQLTCKEDGRGQMRLDLLKEHEYIKKTIDELNAQEEQHKVEYNKQIEDQIEAQKARLKQLKSEDCPELLEIIEEERRNSDILLTAALEALDLEHTKEQSKLESKHGAMVGARSYLSHVVRKAQEEKEKFDAIRKVNASEIARLRAAIEAKKQKSKEHVDACVTTPTPTTPISRPTKLPPDATKSVQCIVVNSGCRIPQPKDASVHFKVSYNPSMPESKQTPTLLSTPGSVKDSRVPFPVSASSSQSDPISAQAIVKKEPRRKCIRRVPAANGNGDEPKAELDLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBX6</accession>
    <name>A0A061DBX6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770269.1">
        <property type="nucleotide sequence ID" value="XM_012914815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBX6"/>
    <dbReference type="GeneID" id="24566624"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405670"/>
    <dbReference type="OMA" id="IYDNYEC"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="987" mass="111267" checksum="8ED857E6E8392423" modified="2014-09-03" version="1">MKQSAGSAAFDGSRERAEASVSSLLSSFYDVDQQDEATDGSKAFSPNDQSQDSWDEALMSGAIFGNEDFDVDQCLTTALKKYSMVELIALLRRLEREVRQFTAGKQILIYDNYECLFSSLDTVHEINADLTVLQKQLYTLKSSQIKASSVDISSRYGFREKLRGITELNRVLNIFQALACIATCLHNATKEPTTGDESKEHFFKLLELLGRVYVILNVVRERSGPKTANIKLFQTFNQKIRILIPNVVTGIVRHVKSEFMSQNVLVDICCNLAVTRITAKQLWEIYWVNKSLGLKSRLQELTNEVSDSSVTLHSLSNHVINFLMYVLEAVYSDGYFKLARFIESNADGMPDGDEAIAKERDMACIFCCEDDCDIIFEYHGNGADGSVEEEHAGNNTAETPVYKYYWLANHRPKQCVCIKENIVEQFVVCYVQLAFATLQPRLMDRSKHVTWNEIIFVLTCILDKIKSVPKGETMAKLLADISFGWILLTVLLYLQKQFYPVYDAVASAIVSASEGRNDDSPFEDVYIKVERILKDDVADVMRFVDDLGDAMHLSLRPLFTSFLAFYIGSLKSVFNAQFNVLVHASEARQEDEYSLGSLAWLLSLRGNKESNRRELMGERIKESRANYRHAEANKSILGIAFDEESVESELLLLRLGLSVEHYLEWKMRMHAKDLPPVGNNMRATLTHLVALMAPFNGVFNRIKTLTGQHCSGASSMLTSGALEMMLPNVPISPVNVFDKEINTCTYLTGLMDFAIGQNYLEGLLRNHHIHLTAMVHAAHRFAKEHSTFGLVPIIKVASCDVKRSNRYALMEGSVLLDMHHITLRVLSHVMITCMRRANTLIRHAMESLEYGDVAAESAVRDLTGVLYDVIEFLNATADPTLSGEITYIQVAELNRKLKYMSSKSDVDAYNVIQELSFVPSKDMCLKLFTIHVAQSIARNSRLHVISKETLRGLTSRIEKQLVMAFKKSSDAEQMKRVFTQLASTDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC83</accession>
    <name>A0A061DC83_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0401440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769838.1">
        <property type="nucleotide sequence ID" value="XM_012914384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC83"/>
    <dbReference type="GeneID" id="24566193"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401440"/>
    <dbReference type="OrthoDB" id="28939at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="138" mass="14862" checksum="0950EA89AA2412DF" modified="2014-09-03" version="1">MDDLHGSGDGLSESSTTEEMAQASRSVPTGIGERHKYSIVSEYGLDSCALSGIHGVDGDRVLSTVPVVKPAAPVVATEGRRLQQLCLLRVELSKALDRYTGLLHHSNENVSCDVRSDSEVLEALDRTLRLLSTVESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC93</accession>
    <name>A0A061DC93_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mcm6 C-terminal winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0401590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769853.1">
        <property type="nucleotide sequence ID" value="XM_012914399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC93"/>
    <dbReference type="GeneID" id="24566208"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401590"/>
    <dbReference type="OMA" id="KRYLTHN"/>
    <dbReference type="OrthoDB" id="328333at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mcm6 C-terminal winged-helix" evidence="6">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="118" mass="13946" checksum="8919E8AAFEF08B6B" modified="2014-09-03" version="1">MSQINVASNFAVDFDAYVHFAYYVGKYLMRHCSNETCDERKVVNWYLDHFRGLLCQTQSSASKLQLVYGKLINNLIRDECLLIAEETSERRTIKKHPSFFVWAWRSQAKSHEYNMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF8</accession>
    <name>A0A061DCF8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768870.1">
        <property type="nucleotide sequence ID" value="XM_012913416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF8"/>
    <dbReference type="GeneID" id="24565225"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305880"/>
    <dbReference type="OMA" id="HWDEFQY"/>
    <dbReference type="OrthoDB" id="360406at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="422" mass="47144" checksum="F40128756B412694" modified="2014-09-03" version="1">MKATSHPVGIERVPSRGGHLESPKRSTGTMVDDVVFPPDVFSALWRRPGRVSNNLVDREGISATSLRSKTAPARQMVAKWSGWRYKHDSESASDCGNDSHAANTYTSALYNKLSSMFYEFKGYMYSNWQMYSAGPSDRPATTAPMETCNAGSKRFMWPMDNLVGRKGNAGPFVAFIPNFSTLNPGYEFSDAFVPHHDNFVDCFALFIEGDSASGNQAEPLRRSESNTSVESMGDSVICEIVNKVSQKVISESGPYQCVFEEEIDSRTQNDKLRNLMSELPVSSGRIKFFQTIKSLSKTWENRYRRQGGPVARASDPGPTDGTSTASYIKQRLGLFSDYLSRRSEGALSAASLRSYFGGLRARRNSDPTELSQSDDNARNRLEDHIQVHTSHWDEFQYDDIEVILRDDNNNSVVQLPYGCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ4</accession>
    <name>A0A061DCJ4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0306530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768935.1">
        <property type="nucleotide sequence ID" value="XM_012913481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ4"/>
    <dbReference type="SMR" id="A0A061DCJ4"/>
    <dbReference type="STRING" id="5866.A0A061DCJ4"/>
    <dbReference type="GeneID" id="24565290"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306530"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="10255923at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="103" mass="11439" checksum="BC05CF1C78AFAF98" modified="2014-09-03" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEEVRGVLKVFLENVIRDSVTYTEHARRKTVTAMDIVYSLKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN1</accession>
    <name>A0A061DCN1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">41K blood stage antigen 41-3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767856.1">
        <property type="nucleotide sequence ID" value="XM_012912402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCN1"/>
    <dbReference type="GeneID" id="24564211"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208240"/>
    <dbReference type="OMA" id="ISQTDYG"/>
    <dbReference type="OrthoDB" id="329354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="391" mass="45178" checksum="EA2DAF0CB8FEAC3D" modified="2014-09-03" version="1">MKSYKTRQMLLESNEYTSVCAYISGVRLPSLFQQMCKSNVFAEWDTDFVEDSKSIPSIEIKLSPPENPLPQVSHEIDKLEARRVQMEEGMMAKLEDKFNETLVDSRDKIRQIITQQLDLFNDERLKTIVRTVDTKKESHLKSHMYEFVSFNLNESLRLPKAPSFIEIGEQVVPSSVRVMMGEVDVPDPAIKTKMEQIEQSRSYEEVQVFNQQSDELEQLTNVTLIGRLPAVRSNMLLELERALKLQLKPYIAQLEVGWLICDNVDLNLQLYQAQAHTPSTPRAQRQPKQAPAFIQTYAYPLPNTKQLNVKIGQSEEPYPTVEDYVMNMEKKRDAAERNERNTVLTMYLKLVKAQHEMIRDELRVATSNIISQYGGIIDATTTQAIRKHRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ9</accession>
    <name>A0A061DCQ9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vps53-like family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770133.1">
        <property type="nucleotide sequence ID" value="XM_012914679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCQ9"/>
    <dbReference type="STRING" id="5866.A0A061DCQ9"/>
    <dbReference type="GeneID" id="24566488"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404350"/>
    <dbReference type="OMA" id="QQFYHTI"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="881" mass="99090" checksum="10887033709398C9" modified="2014-09-03" version="1">MEGIEEAPRYDLAKFVDNPVEFLNEHFTDECNFADIDALIAEVKGEMRQQDCKLMEVINDKAISIEMAHERFEKLQCATNDLIAQMAEIQIPTMRGEQSLKILTADIRALNHAKNNICNTITNLKRILMLSTMLESLREKAKNRKYNEAAGLAVVVRELYQLVTPLREAPPVVRLLTACKTVMNNLKQQITEDLEVMLALSTTQKYMDTPLELEEVCKCADAIDEGIRQHIATKYAQHVTKSYESMFSTTFDLKTLDNINERFAWLRRTINEFDELYGTGVPEFWRIQATGAWAFFEACRSQVVATLTRSKEQFDANVILTSLLRCKEFEQELDYRLSNYCDTPTSVERQAIEFPEAVPSPRQTDEADTEQRKPLKGVLSRCFENHLGPWVANEEVQLDVLYQKIVSNGDDAIIMHVLRSAKELFSAISVRLKAVLAVSSEQTLFEMSMVFRRSIGKYQVHLQDKLGKVEKHAPLQKVFKQCGFITATCDYVTEMLEHLNDEIVEAIAPAYKEKVHFNAEKEKINVTKSKAVKRLIDESCKFAPITPNVVAPLKSLEERVIQVITLTVDHLPSGYLHYVTNKVTRGAMAHLKTTIFSLASVTEGYCQQLLLDSYSLQKLLLETVKTLVDPLPLGYLEATSSEMDKLQTLIKVLNSAASHTDAFEALLIENGGTCTKKELDQILAIHRKKQPLPCLGAFAVLLVFRCEPAAQIDVHATSHLFQLARDVSRVHRNRLQQADHVEQLAVTLVAVKLTDQNGVALLQRAGHAVVVEQDNAAQVTTQLAQVLDVRPFELGAAVPVDATDDGEPPTIGNVRRHWVGVVGPQHNLVVVDQLAEEPVRVGALLHLPPGATVVLKLGHHLVQVDHKGREVRRIVQQLHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR6</accession>
    <name>A0A061DCR6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0307430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769025.1">
        <property type="nucleotide sequence ID" value="XM_012913571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR6"/>
    <dbReference type="STRING" id="5866.A0A061DCR6"/>
    <dbReference type="GeneID" id="24565380"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307430"/>
    <dbReference type="OMA" id="YDILENW"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF93">
        <property type="entry name" value="VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="9"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="577"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="912" mass="99281" checksum="E190464601AD9BCA" modified="2014-09-03" version="1">MPCKGAVRLITPPPNLTGDLHVGNALNLVCSDIYLRHAELSNREVYARFCSDHAGQGLERIVNRGVGVDKPPGQRLRCALRHCKTVSDDHMDTLSSLGVDWLYGGWTLGRRSKEVTRHAFVSLYRGGHLAEKLYPTFAKVTDEVVTFLDSADVDLVRQPKKLYAVDLKLVDDGGSQPAAASSDAGSPDGHPSRHSDSEDYITVHTTKPALLHASAAVAVSDSTSGRLKGKAAVLPGSHRRIPLIASGGVDDDRATLVMPGYLFEDYQLALKHGLDVIDITDERGRLKNVVPELENLTIAEAERKIIDGFAEVATVEEPSPTLLGDPSCDVYTLPAPHWLLDVSAISGPALDAMAGLEVDPPSRSSMLRQRVASTQPWCISRYGWWGLRVPVWYLRKDGVSIPFPAQSQSEAEQMVAQYLQCSISDALSRGYAIEQDTRTLDTWFTSALWPITTTPDTYSPPLAPESFDSITLSDGIPLEGVVVNREAGGEVDEGSTLEEDAMASMEANQKDGVDRGGASNYDFVDQKGASNCDFVDQGGASNCDFVDQKGASNCDFVDQGGTPKRDLALSHAATLCDANATRVLYTCYDILHSWVARMLLLCTWFSKGKLPFDKLVLHGLVNDSSGRKMSKSEGNTVTAKEFVEGFGQLPGFPDLSKPSEIDILIAKAVGKSVKHTSPLAMAQARLVLATAASKANVCHDLGGYADRVKSLLKKVANITKYVSNASKQHGLDHMWDVSPDEVGKTFVERLVAAGLSRAGRAVGDCIETFSFRRAFENLEQYVSVFSEYAIPSHRHGDMGIGALATGYRDLLRLLMPFTPQLVTAMPIPIGMKDTGELFEWPTFGAPVAEDERAFDVLESVIRQLRRHALEGSENAKVEAPEDLRGAVEAHRPLLTYLLKLTYNTVIHFNVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD00</accession>
    <name>A0A061DD00_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0309020</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769185.1">
        <property type="nucleotide sequence ID" value="XM_012913731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD00"/>
    <dbReference type="SMR" id="A0A061DD00"/>
    <dbReference type="STRING" id="5866.A0A061DD00"/>
    <dbReference type="GeneID" id="24565540"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309020"/>
    <dbReference type="OMA" id="TCVAYQL"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000475">
        <property type="entry name" value="Calcium-dependent protein kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="202"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR96999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="657" mass="73890" checksum="03E5D88E0D5419F5" modified="2014-09-03" version="1">MQVDHDGRFDNADNLRGGKSPRIEGTPRRSPQAHAAKYAKNHPEGADVSLLELPPNAIDHVVTNTTAATHSTIVSSVSPVKPGCHEHDCHKDKTQDKSSWTTHNPLARAYSSEQHGAVPKFKAATSMGGSHKPEYNSLCTKCMPDEDRITRGFKGLLIQTPIFKYVKDPKQPGKESQPTFDRSFLIHETALVDGKSITDVYDLHSSRLGKGSYGQVLKACHKETGEVRAVKVIRKAHIENAMRMKREITIMKTLDHPNIVKLLEIYEDEECLYLVMEMCGGGELFDEIVRRGCFSEQYAATMMRQIFSAIAYCHGKGIIHRDLKPENILYSNMSDNSPIKVIDWGFATKCCKAHKFTSLVGTPYYVAPEVLIGNYDKSCDVWSAGVIMFIMLVGYPPFHGNDNATILNNVKRGVINFVPHHWKKISRGAIDLITRCLSYDPRYRLTAKAAFNHEWILKNATSIHVNPVLRHSLTRDLVKRFQKFDNYSTMKQLALTCIAHQLSDGDIGSLNTVFNVLNNAGDGVLYVRDIVNGLQSDKVKGQYDPAMQRLVEKLDTNGSGAIDYVEFLAASIDEEVYMQKDFCKKAFKVFDLENRGVITRDNMRRFFQGDMKGCDFSEDFVDEIFNEVDLDRDGVINYTDFCTMLYGLSRPGEAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD42</accession>
    <name>A0A061DD42_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768121.1">
        <property type="nucleotide sequence ID" value="XM_012912667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD42"/>
    <dbReference type="GeneID" id="24564476"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210850"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="194" mass="21639" checksum="89A28409A606A03F" modified="2014-09-03" version="1">MIRVGQLQRFGVAIGCKKLAGAVGDNCCPVGCRRCKKICENRVPGINGEHDINVKCTCRTCKGFVLNKPGEQPCPTDKCRGHGLIDKRGNIRKHDDGKCHGHEPETVYKCYFGEERDEFGNCTMKCKDCLFIFWAMFPEKFHAMMGKIRATFANSSESSRATTKSLVGKRIPEEINNEKYPALRPRAYAGLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD92</accession>
    <name>A0A061DD92_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0311020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769385.1">
        <property type="nucleotide sequence ID" value="XM_012913931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD92"/>
    <dbReference type="STRING" id="5866.A0A061DD92"/>
    <dbReference type="GeneID" id="24565740"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311020"/>
    <dbReference type="OMA" id="FEIFDIH"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="53"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="288" mass="33715" checksum="C1AC9B04DF6A008E" modified="2014-09-03" version="1">MAEEAAKPPEEDDVLNFFFSEIESIGKAKSDADIMTFNAKEMCLRLTSQTFASPYQVLQLKHDATEEEIKKRYRKALGIGTQISLLIHPDKFKHEKAQEAFNAVLLNAFNEIQKSDSKEKYKLVYEEAKKIVYKRHKANPNATTLDLIAAGVLDSDIQQIENEIQRECDEILRKQQERREYAEKCVRANMEYEKQLAAEQVELEKQQLNHQVEWDKTRDLRVTSWRSFQGKVTTKDFKLQAFRTVDPKREQRPDVEGTKRGTIAESQTNRKEKRKKIVHTDEYKASWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE4</accession>
    <name>A0A061DDE4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0312170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769500.1">
        <property type="nucleotide sequence ID" value="XM_012914046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDE4"/>
    <dbReference type="STRING" id="5866.A0A061DDE4"/>
    <dbReference type="GeneID" id="24565855"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312170"/>
    <dbReference type="OMA" id="YPPILMH"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="557" mass="59877" checksum="1843477DB55A6B0D" modified="2014-09-03" version="1">MTTVRLKNVFGEPFKQAYCDLKINPKPTAFSPGMAASNTHIAFPWEVGGGGLITLINIDKLGRNSGSDRMNFKGHTGSIQDITFNEFDNNLFASASDDGSVRVWRVTGEQDSTAAANLNGHTKKTTNVVWNSATDFVLMSGGLDNTVRVWNVQNETEVVSIPIEGQYSYCNWSYDGDLCVVATKEAGVAVVDPREGKVSHSFKAHESNKATSVAWLGGNYGNDHLATTGYVGNQTRQIRIWDRRNTDKPLLSKDIDSAPGPLIPHWDSATGLLTVVGKGDLTVRIFQYLENELNRAGEIKCSGTIKSFCFLPATACDKSKCELGRMLYNNSGKEINPISVVVMRRNSGAAMDEIYGALQPRRRTSAKDWHNVPGRSAGVSVESSLTEGSSSAAVTSTSAAAYDAQSYHAAPSRTIASDNSMSFTPTVPTPPQECETTATGRAFGEICASLGVLCQKYKPTFDDADMIDELETFKGDVECVIAKLRQLHNIPAPAQEQPQFTSMLSGEPKAPVRIVSRDEGRPASGSSGLSGVRAAIAAMEARAQAKAQAQANGRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI0</accession>
    <name>A0A061DDI0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769610.1">
        <property type="nucleotide sequence ID" value="XM_012914156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI0"/>
    <dbReference type="GeneID" id="24565965"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313260"/>
    <dbReference type="OrthoDB" id="364990at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="181" mass="20458" checksum="8BDB76F200971A65" modified="2014-09-03" version="1">MKRAADEQTLKEQPTEERVVPPAKPLLPEELELVGIHRDITQHLLSSVAPDNGYSFVKLGLPSLEYSLPEGADDVDYDAQYARLRDMIDVTLFPDELLQAEYVSAGADSAGHEVTDVKQAIRKIDEVMEREAKYVEEEEDPKAANERPDDAMEVDTSMYNDNDDQLVGDYHYSFCEEDDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDM1</accession>
    <name>A0A061DDM1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768561.1">
        <property type="nucleotide sequence ID" value="XM_012913107.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDM1"/>
    <dbReference type="GeneID" id="24564916"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302790"/>
    <dbReference type="OMA" id="NFFIYQY"/>
    <dbReference type="OrthoDB" id="2021145at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1643" mass="182753" checksum="26D29A3F5ECA9E57" modified="2014-09-03" version="1">MRGRGGSRGRGGIRGKAVSSTSRGFPPPPAPYGHANAGNPKPPPVQARQGGPASTQQSFRQPPESLSVAGSGSLKHTSAAVRPMYGNDVVRTMHVPAGNPQPYQKAAPFKAQMRTHGSKRAAPSYEQVPQEHTNMHTFNELMKTGVLHPMMLGQFVPMFSMGAAHPVPEPAAAPPSWKRTRSPPPKRPAKAHVAEDAYVHKMATLEYMVDAAAVQARMDFIILALSKLHDAMSRIKITIPSIFRIRNNFRLRAAEEEMIGSVEEVYRFVLITHLAKAHKLQPPYDFQRSVEGKMQAKEPLLQFAGAKSNLAVINVDELQSVISNQPLHYNPNWSVLRWDEGEEAKGMNPAVSNRPYYVRAVQRHVPELKDGFKHAVFLRAINVQMFEEHLDVVHLLCNVGPSAREAVLRAMGYYALSCDDDAFITLASSILPALDSDAQVQFYRQIAQLIDPRTYRLATIYVERYFERILPMCLAVPDTRAWASTIVLLMRSVDPLRLGVKSSNTAITLLRTLKSWCNVFVKCEDTCVEVFNKCIQLVLQAGDDSRIVIRGAAADLAVQIWLNAKGKAAVLNKIGYDTVRTLGCISGVQAIKFNIWSDLLTLEAPEGAAKTQRVQPLDLILSRMDQYDAVEQSLHHEESAFVISLLTAEPSVLGYLINWYLLRYCKITKTVFALEKIASVIRFALVAYPRIAKLALPHTSHNVGTFCCWMLNMATNCSVGSGCLELANIKMALFVDWLFFNYQYNARIIRLCFGAAGTAQCDQVLNNMHQCRRLFVKELAKCVFITRRPDNTAVDDNAAKIDVLLGTNEVLTFTYNTAVDTFRRLVDYLLNAVLHYHSEVGIVAVNAMSAIFMVSVLEMPRAQHTLGTLLRALKNTMLGRMCSVLDISLEGITVYIAEVGDRETTHVLQLKTALQPLHDKYTMVVAVKEKHRNACYDETLKALMLQCYGMVLEYIINVDSLNAIYHGNHLTVDTLRANQELELLEQTQCPKLYTNVAIVNTDSSQSGNGSAVGRNVNLRGDAISDISDGADSDSISDISSDDDEPPISDKYSISGANREKNGGLQTARHPDGLSTTSEGTALECEEKAACELSMSPTKLRELVQQFVHASMDNPAKDFAADPLYTYLKNSLVDSGEPNYAITLLKTGDSSYTFRFVQKLRNAPDNSKAYAVAHVVDVVASYLLETALQCLQDDASSGASFDSILFKEWVVHIFNAFVRLCVAVYTAGYVSIVWELLYYIAAVTTAKQHTGGHARIDEAKIQNQPTEKDMPAPARKKLLIVATLLFNTVDSVTQIKSITQDSVMMEALEHVIKRVVGRVGADLATIVQNLMPMRFTLETVFKSSFNHFGRLPSIMGMVLRIAPVTAITSLIDIKSATMFNVFKEAYLKGSEAGPYVRALFALGSSNPMQRRHSFIAWQIVCRMYEMAFCTNKMRQTLKQERNFLKVTSTQTLPKNMGKLPFITEADVGENKIDRDSILCYLGVSGNKRVNFMSFQRGYTFAKELFVNEHVQLLSHSMVDAFKAADIAQMQIALFSAFPIFVHSVPTQGVIRDVMQSLATIWPKKRVIKSQHMQFVCDMLLALITHWLARYPHLLTVFDHGLPNIRDALDQLAIKYSAGRTMQFAFNGTTLKVQLEHVLALRNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS4</accession>
    <name>A0A061DDS4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768711.1">
        <property type="nucleotide sequence ID" value="XM_012913257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS4"/>
    <dbReference type="GeneID" id="24565066"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304290"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="80" mass="9392" checksum="8C435520B0B0913A" modified="2014-09-03" version="1">MERRLKFSLTQNHAHTHLNDKIDALEVSKYFLLQCSSPTMHSECPQSQLMCGCTASRERAPMWYRYPDQNGSLFSEIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDU1</accession>
    <name>A0A061DDU1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0401800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769875.1">
        <property type="nucleotide sequence ID" value="XM_012914421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDU1"/>
    <dbReference type="STRING" id="5866.A0A061DDU1"/>
    <dbReference type="GeneID" id="24566230"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401800"/>
    <dbReference type="OMA" id="WLFTCES"/>
    <dbReference type="OrthoDB" id="387094at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF229">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="531"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="94940" checksum="234570FFD4546B30" modified="2014-09-03" version="1">MSGGMLGGLLGHGIDLGRLVKTDGTDLFSGYANAARDRLPKLADSVADAFGRVLDIFDRPVNLRKPEFDTAAPKPSQQADLADAHRDYDVEIKEVSKPRINETLHVDYLADVTRAQFKATQGAKACSDGDDAAPRADRKRPVASASPCDAEARLCSSCYLSLATVRCDSCVMHLCAVCAVERHAEGLQRSHKLVTATSGKEARLNASDALSGQLSYGHLAAGASGSLAGNFSKDLSINIRPGESAYPTYDSCAVHRGLPLRLACVQCHLLPLCETCASEAHSDGAHRVVEIEAAVAEVKELLGECLSAVVRRHNDLSVVLPELQQLSDASSAGLKNTTRSIRSGVERTLDALKLKRSLGSQDIRNMQQVGSSALNRMMHASGVLNRYLRGCVSQLEAINRVQNPGMALNMYVELRSNFEKLLFTDEEIPDLVLEVPHWQLHCGNLPTLLSDYEARINTNIAQIASLTFTLRKQVRETVKKIEAASTGTASATSQPQQPARPPRRHAERRTRTPGFTTLPDGSPNTLDIVTHAELKALFLRRDSQRCSWRQRAVYLCGRRLFVLESDLFADDVPVESSIDLAAVTIRSFADAAAMDITKLQRMGHPNGFEITERKGRSLRYWLFTCESEKTVQLWFTRIMQLSNYFKAELQSEASSNTDVESVDPASEDVAPVSATLQNLHFANFNAPTSGAAADPKGEHETCEKAHDPDYFYDDSNFKLVAESLRKIKNESRSLYDKCFKEEREAKAATWKVQPVSNHAASLPHSLSASVADGLSVDSGSSRSSLIAADGSSSGRYAMPELPTRRQVSRAAQTNVFSGRDVQLHEAVPAFRRSPEVKSPRSIHKFFQDLARRLRREEGCDILDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE26</accession>
    <name>A0A061DE26_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768966.1">
        <property type="nucleotide sequence ID" value="XM_012913512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE26"/>
    <dbReference type="GeneID" id="24565321"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306840"/>
    <dbReference type="OrthoDB" id="365035at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="114" mass="13069" checksum="2C4C0CAD22E41F85" modified="2014-09-03" version="1">MEGHKIVLSDDFLQDFCRSKNASYTKTQPGRSDEVEKQCRGWEHRLARCLNSCQGVISASCRASEAEAGGETPSGYFRKVLECSKDFREYEACIRRKDKWDAKPQTDRDTTHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE52</accession>
    <name>A0A061DE52_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exonuclease family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0307340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769016.1">
        <property type="nucleotide sequence ID" value="XM_012913562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE52"/>
    <dbReference type="STRING" id="5866.A0A061DE52"/>
    <dbReference type="GeneID" id="24565371"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307340"/>
    <dbReference type="OMA" id="KCPLNLR"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="275"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="679" mass="76255" checksum="8BFC3CAA0C4D8DF8" modified="2014-09-03" version="1">MASNSERAEARQRDCSLSVADGHSYTLEPVLQHRSAPIDWIQLQRFVTWLMSVNAKTKCPLNLRNGRVHSHSNVFIAVPYLDSDYLMNDLDALKVVQRSTESGTLYRIKSPACHISEGECDIMKKFLFMEVKKQIRPDESHRIAQFCLTPEMYHNAYNPGHAENEQFEDLDCHPAEFVNKMEADISEDQLLSVLESNVLTPRRLCRNQDQLVAAVNRYRATPFTAELAPESASSSGETSVDDDSVGTPEFKFSDELLRRYASIAYQLRNDGLFPKTFALDCEMVSTTKGTELARITVIDSLLRVVFDALVQPSCTVTNYRTQYSGITEQGLAGVTITLSDVQAALYRMVDCETVLVGHSLHHDLSACEVGHGRVIDTALMYAIQNRRNKPSLKALAETHLKLDLLRDAGHDSYVDAATSMYLAMAGVLDLEPPSTRNIGILGQEAFSLLSRPEEQFPSPVVHLIDPMADHYKHQLDSGITLEQTSDDGSSVDRLVELLRSNRGVDSACYYFLVLRDFQKMCLRKMFESPKNEEAASLTKRANPKSVCEYMTRLSALTDRVVACLDRDDVMMMSNLSGDTAKVDVLSQSLHAKTPGRMSKLSRFLWRLYALGNGEPAPNHANMGEMADAPEPVEKFSRRTQIVTVATLKREHEMAIRDRHLNWAIFLTKKSSNKRKPTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE78</accession>
    <name>A0A061DE78_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0308040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769086.1">
        <property type="nucleotide sequence ID" value="XM_012913632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE78"/>
    <dbReference type="STRING" id="5866.A0A061DE78"/>
    <dbReference type="GeneID" id="24565441"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308040"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="475" mass="52082" checksum="1367EE1A84F7C603" modified="2014-09-03" version="1">MDLNVVDSAPSGNKETAAEADFMDQIVKKALPSNYNFEIAKSVAKVRQLRAKKVALQMPEGLLSWGCEIADILKFFCESIDEVIIMADVTYGACCIDDITAQAIGCDLIIHYGHSCLVPVTSVTVQCLYVFVEINFSPHYLAKAITQVLKPQDKVFLMGTIQYSNVLREAAAIIDETGHFSNKVIVPQVAPLLPGEVLGCTSPVLHGCEFKRNERATSIVNGGDCACRSNTDAGSRCCMEPPAAANGGHASADAHLNANGQSDPAIVDHSGEGGERTIVFVADGRFHLESALIQNPGIRAYRFDPFNKTISEESYDLDTLHSTRGDAIQRAKSAKSVCLVLSMLGRQGNINILKNLTKMLETAQIEYHIRLLSEITLDKLAQLDVDAYIQIGCPRLSIDWGAGFGKPLLNPYEAYVAYNKEVYKSTYPMDYYSNAGGQWSNYTANRKGAPPVDSKEAIRRMLQQRARAKHIEYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEF8</accession>
    <name>A0A061DEF8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769391.1">
        <property type="nucleotide sequence ID" value="XM_012913937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEF8"/>
    <dbReference type="GeneID" id="24565746"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311080"/>
    <dbReference type="OMA" id="EITHIFW"/>
    <dbReference type="OrthoDB" id="405976at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="32213" checksum="9627E80A5A555308" modified="2014-09-03" version="1">MFPRALVPLCFNHAWRLPRAGRVQPCISQFLSRQWHSAAFTHRSCSLALPAASRAPLPWLAEQVRHFAGRQRGLKRRKSKSEPRRIQRAVGRRLELFYPKRARRTRIRLVQNSRGNVIFDPVLRRFLVVYYKQGVQVFRQFRATGSRFEIARSRAIAFARQMAEEHLRRYRARPGASDDALPSPVGSNIINLENKLQPDCNLSGVRGVFFDAKSGAWVAVYKDAGVRKYRLFPTRELGFQNSYSQAVEFLRFALYRNHQFLHRRTRTRKNRPALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEG0</accession>
    <name>A0A061DEG0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769401.1">
        <property type="nucleotide sequence ID" value="XM_012913947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEG0"/>
    <dbReference type="GeneID" id="24565756"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311180"/>
    <dbReference type="OMA" id="VECAAVQ"/>
    <dbReference type="OrthoDB" id="365964at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="397" mass="43259" checksum="06A7CBD3A46C629D" modified="2014-09-03" version="1">MDCSFLFGSQSITRLICAAIAYIGFTKFQKVECVGVKESPAGEVVVSPQSVLAADSLVSDIEVTENGAKDIDNCRREGNVAFNSTTVGGKSALERLHADEVAAIQANRAHGTARELNDQTALEFIQMIFNEHLPRKEFWLCWFRNRLLSLTEPSETSSSPTAAPSGNDELDSPTGSSAGRNVRGAQYNDTADKRSGVSQDANGSSIAKSSQDICRLSKVWQFTKGLYAFAKSMLFRDTTETNVPRRSIKRALADCGRAVAGKVGRGVVSAVSTVSSVLGYNDTPFQNMKHIIMHLFSPESEVKEGPEEPAHAALDEECFLEKMARLNAFYQLEIANTPIYADRRSFYGPVPKTLHVANAEAPFETARCRSAAHYVVVSSGKFASLSLYTLFAVMLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEJ1</accession>
    <name>A0A061DEJ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0312730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769556.1">
        <property type="nucleotide sequence ID" value="XM_012914102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEJ1"/>
    <dbReference type="STRING" id="5866.A0A061DEJ1"/>
    <dbReference type="GeneID" id="24565911"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312730"/>
    <dbReference type="OMA" id="IAVCSCH"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR97370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="354" mass="38997" checksum="5338CC8A089789C4" modified="2014-09-03" version="1">MQRPLEGQPAATGSAEPLSGGLNAPEPTEGEVTLRSENALVVVLDLTPVAWTGSLAPGEPRLQLCGLYSLLHRFLKTFAYMSAQSRCCVIGVHSSGTRIIYEGVLSTDWLTSCFGGDRSQDERVTALLLRIWNSILDFIDTWSASSGDPQLTTALSMGLLYLNRLRLTGAGYGRRIIIFDVSGAKDYRAQYIRLMNVAFTAAKSWILTAGQGISINTCAFRQSSVGTTVMYAHQTQRILEQLSDITNAKYLNLQKILQSEIDAENYEQSVLQLIMFWFLPSEAVSEQLSTQLPFDFSNTAVCYCHYRTVDIAFLCPCCFAGKLMPALVVTARQCTARKRTIRGSTESSVSYASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEM2</accession>
    <name>A0A061DEM2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartyl protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0400170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769711.1">
        <property type="nucleotide sequence ID" value="XM_012914257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEM2"/>
    <dbReference type="STRING" id="5866.A0A061DEM2"/>
    <dbReference type="MEROPS" id="A01.A95"/>
    <dbReference type="GeneID" id="24566066"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400170"/>
    <dbReference type="OMA" id="MKWFGVL"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595765" evidence="8">
        <location>
            <begin position="25"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="148"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="179"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="469" mass="52198" checksum="B06135D853DAC603" modified="2014-09-03" version="1">MVSWKRCGITTAVVFLTALRLSVCDIDSSSSEAITGERCLRFDEGGCSVWLHKGNPAEHSISLERYQIPGSVSALQMASSNHELFKKGKISFAKRGEGVFGSIGYDGNKNRRPAFSTMKNKLNKRIAMLKRCDRANYIPIKQTKDSLYVGEIKIGTPPQTFHPIFDTGSTNLWVVGSTCKEPSCSKVCRYDASRSTTFKMMDTPIKIHIKFGTGEIEGYPAKDTVVLGKIAIPDQSLAVVVSEKSAGGDNIFDKIHFEGIVGLAFPEMSSVPGMPIFDHMALLKNMKHKEFAFYIDENDKESRIMLGGIDPQYYLGEIQMFPVVREHYWEVKLDAFYVGNEKLCCDGQSSYLIFDSGTSLNTIPSSYFGHFMSYFESKTCDVGADYPTITYVLEGERITLEPHQYMLRQGKRCVPAFMQLDVPSEFGNAFIVGSNAFMKHYVTVYHRGTGGKASMVGIAKSNHSATQHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEQ0</accession>
    <name>A0A061DEQ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">-U3 small nucleolar RNA-associated protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0401570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769851.1">
        <property type="nucleotide sequence ID" value="XM_012914397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEQ0"/>
    <dbReference type="STRING" id="5866.A0A061DEQ0"/>
    <dbReference type="GeneID" id="24566206"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401570"/>
    <dbReference type="OMA" id="QNWAHLE"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="5">
        <location>
            <begin position="174"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="4">
        <location>
            <begin position="436"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="610" mass="69696" checksum="B89AF58D19892638" modified="2014-09-03" version="1">MEGDDSESEPPSAFEHLLQVLGKRSRSDKRRKITKSDSNVDNIAKILSDSFDADAESEPEEVSEESSDGICLDAFDSFNMGYDDYLRATEPITATSPIPIPFFKSCQFKFLTPILQQVLKSKVLPRVVSGINSFGFHEALQRKITKLHKKARSGGWMPKDRSRLRYFFNCMNSYLDVFYAGCKVTDVSSMRFLMALHAANHICKSVTSTVEQSHGFTRPRVLYICGLKCMARDFIQHLVTLLSVKKGDPKVEKFYEEYDLPEEDTAAQVSSFSKTHKSLDYVETFSGNQDDAFKMGLRYQGGMLHLYTPFYTSDIIVTSPLGIKIMLQEDEEYDFLSSIEVLLIDRMDVLKFQNWQFFIEVFEKLNRPLKKWRDADLSRLRVSTIDGQSEVYRQTVGLSCTQHFVFNAFFKRLVNRRGFIKLASVPTQDFVLLGSQLRVKQLFIKVAASSVTDADGSLLNYFLKNMLNSIQGIGGVLVVLGDYTHFLRVKKELKMANFEYLPCHESNSSKQMLFARQQFQAGKTPVVLTTSRLLFFKRYVIKGTCRVLFVVPPDYPEIYREAFRMLDLSKNNALVTLYTRFHAHQLEPIVGAAKVHKLVSAADTKVTEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DER1</accession>
    <name>A0A061DER1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0402105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769906.1">
        <property type="nucleotide sequence ID" value="XM_012914452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DER1"/>
    <dbReference type="STRING" id="5866.A0A061DER1"/>
    <dbReference type="GeneID" id="24566261"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402105"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402105"/>
    <dbReference type="OMA" id="SSFWNVA"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="17092" checksum="7A2AD7B76B509891" modified="2014-09-03" version="1">MSGGRHSRAKELAWSLLYTLCTVHVVTNYVVDVTMTQGPSMTPTIDERYAVALYVRPHLLRALRSRSPTLYREGDVVIGISPTNASRRICKRVRATEFERHGGRIVPRGHVWLEGDNKANSLDSRYYGAVSSHILLGRVFLILSPNQGVRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYM3</accession>
    <name>A0A061CYM3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765922.1">
        <property type="nucleotide sequence ID" value="XM_012910468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYM3"/>
    <dbReference type="GeneID" id="24562277"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100650"/>
    <dbReference type="OMA" id="PRENHIV"/>
    <dbReference type="OrthoDB" id="366239at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="524" mass="59084" checksum="CAD0FA7DE9745470" modified="2014-09-03" version="1">MKGQITLQARSLPQRRCSHVKWASCPFRMPRMPVTFVDEREASTAQPFYREVAAFRLRNSLTSGASEAQAYRIKLEFHSRLCGKIIQHLEKQVRIPDACQGDNARWSCSGLYFVLLHNFNNIHQKDLVVILVAIVKILRGGHHGQYALGALQECAQAFLTCLFTCNDRVLQRVHKIADGSDPIMNKWRSFAELLRQLSEQTQGHALDAQDVSKTSGIGDTGMSCSDDTSCYEKYIGVEEIIEEKRSPARDSGAFACTGCLARDASETLFAKIVGKCTLQKDFARVAFVLYWLSKVGFSSEITTRFFEMNLRRMLALQSDNRSEPCPRDFISVLRYSLHFDIDGSLREALYGYLAASNKKSLLHLTLQDTNNLVDCLLEKEQADQGLLVAVFANVQLSIKAMSSLGGKQPIGVAHSYLAERRRLVEDARAHWDNIFVDFEQLKDLVSAFVGRDSLCNFLQKHCLPPSELRVKSGFDADAVNRHAVFDIVRKLQKLCPAMEETQEYCVKLIESALRSLDNSQHANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ38</accession>
    <name>A0A061CZ38_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0100420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765899.1">
        <property type="nucleotide sequence ID" value="XM_012910445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ38"/>
    <dbReference type="STRING" id="5866.A0A061CZ38"/>
    <dbReference type="GeneID" id="24562254"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100420"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="293" mass="32616" checksum="85D74BED983C5757" modified="2014-09-03" version="1">MVKFGQVVIGPPGSGKSTYCAGAKQLLNSLGRPTAIVNLDPQVTSFELPYTPDVDIGELVDSQKVAEFMDLGPNASLLYAMDYLLANLDWLTGKIEALGDVYLLYDIPGQIELFTHHTALRDIIDALQRKHAHRLTGVNLIDSTLCADPFKYVAALLTSLSCQIFIQLPHVNVLSKLDLLRLVSKDLAFKLEFYTSVLSLDELLSYLKTSSSYRLNERFERFTGALCELIDDFNLVSFATLDVQNRDSVMKLIKLVDRSTGYISGPAFDAYGMDGDLDLDYCVRECEDNGYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ69</accession>
    <name>A0A061CZ69_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA recognition motif containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0100620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765919.1">
        <property type="nucleotide sequence ID" value="XM_012910465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ69"/>
    <dbReference type="STRING" id="5866.A0A061CZ69"/>
    <dbReference type="GeneID" id="24562274"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100620"/>
    <dbReference type="OMA" id="NNYFIDG"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="21679" checksum="E3C94C1E861E0749" modified="2014-09-03" version="1">MDDDAATKSSVIYVGNLPKTLTESQIRMYFNQFGTVVNIRLMKSKKTGNSRGYCYVKFESHEIASITAEAMNNYFIDGRVLKVHVKETADHVRYLFKKGRPILNRRRRLLIRSRDIQESRDRAEATVSDTLNALGKKHVAAETEAEQLRSRLQSAIERMEAKQSRLGTNIHDSAIRKYKRALELLSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZA0</accession>
    <name>A0A061CZA0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="7">AK6</shortName>
            <ecNumber evidence="7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="7">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0102765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="7"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766137.1">
        <property type="nucleotide sequence ID" value="XM_012910683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZA0"/>
    <dbReference type="STRING" id="5866.A0A061CZA0"/>
    <dbReference type="GeneID" id="24562492"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102765"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102765"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="170" mass="19240" checksum="9E1CF767A2505992" modified="2014-09-03" version="1">MRANGPNILVTGTPGVGKTTLCRRFADESRLRYLNVADLIRDEELHAGWDDELECSIYDDKLLRKSLKKRGLSDGGFLLDFHSVEGIDKKDVDHVVVLSAEIETLCARLKERGYSDQKIDSNIEAEIFQVCFQDAVEQFGQDRVTMLPHNTEEESLQALEHVRKLVASYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZB3</accession>
    <name>A0A061CZB3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL24c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0102890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766152.1">
        <property type="nucleotide sequence ID" value="XM_012910698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZB3"/>
    <dbReference type="STRING" id="5866.A0A061CZB3"/>
    <dbReference type="GeneID" id="24562507"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102890"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_uL24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057264">
        <property type="entry name" value="Ribosomal_uL24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="248" mass="27593" checksum="F92854FEF0259AE6" modified="2014-09-03" version="1">MQLYIQSFLSYRRLPCSWLLPGGSPVPGYCRANSTYRRVPLPLGGITGSVYNTLPYSNDADCSGEVVGGAWALIQRRGPKIVKPRDTIRFWKIRVGDKVTVISGKEKGKSGEVLACDKLRNQVKVKGCNMVGVTTVSDNTTQRRLVVDGQVAHIEKKIHYSNVQLVDPLLNCATRVAIRFSGSNEPLRVSKKSGYVIPWPEEKPDEEKGTAGERRIHSAAQKSSRARRTPRLRLLWSARTTTKRTCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZP7</accession>
    <name>A0A061CZP7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766069.1">
        <property type="nucleotide sequence ID" value="XM_012910615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZP7"/>
    <dbReference type="GeneID" id="24562424"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102120"/>
    <dbReference type="OMA" id="VVRNPDC"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF44">
        <property type="entry name" value="PHOSPHATASE C1620.13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42585" checksum="5BB4DFFB266E1F74" modified="2014-09-03" version="1">MGIMYSFCDILNAMARQHFVIGVAAVAVLYTSVYVFLSSLRTVTDEGDMHQGIPLQQPSFAACSLFKRLVLFGTAVKRFVYKRPNRGTSSGIKAQIEAAKLTDWIDTRTKTIYFIRHGQSMWNLTFNNPYNVIGLLFRVLSMTFAELSFLFTNDTFFYDSPLSMNGINQALELCKELSDPNNHRCAEMQVLTRASGQRSALFTSNLRRAQSTILLALQDRLSHTGERVYVCNELEELVPHPDCVSLSTSVKTAVIPFLEVMMIPDKARTYSQHLQQTDGPVVSHLPVYDKMLMFNERVFKQPEEAIVVCGHSRWLLDYLNIFLPQGATDMEYCKTKIGNTDTLRFDLVRREFKNGEVYYVIDPHSVKLVYKSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0J7</accession>
    <name>A0A061D0J7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0104970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766374.1">
        <property type="nucleotide sequence ID" value="XM_012910920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0J7"/>
    <dbReference type="STRING" id="5866.A0A061D0J7"/>
    <dbReference type="GeneID" id="24562729"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104970"/>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="391" mass="44904" checksum="38D20DBD715A9A16" modified="2014-09-03" version="1">MKFSDDAVVTESNLRFYYEKICPVRDLVRWVSYEGEKTAGLLPRREISFTFQRETGGSATEYYMRWQCFESHRQLQNVLYGRDNVPYKIDIGAVYNKPVSLMQLSGSNFHAVERELVFDIDMNDYDDLRTCCSDKRICEKCWRFISLAAEILTRSLTEDFGFKDILWVYSGRRGIHCWVCDARARALSSEARSAIVDYLTLIGADGHKKRVNLYGIEDHPAVLRAFDICYRTFDHLLREQNFLAKEAHLQSMQDYITDRFPKAHQLLQRVTKSQVSSSCELFNDLCKLLDVETPCEYRESTHGSQARKDAFPTAFRELVIAFSYPRLDAAVTKDIGHLLKSPFCIHAKTGRVCVPLALDMISTFRPESVPTLGKKSLNVLKNVVSCFAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0L5</accession>
    <name>A0A061D0L5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766522.1">
        <property type="nucleotide sequence ID" value="XM_012911068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0L5"/>
    <dbReference type="STRING" id="5866.A0A061D0L5"/>
    <dbReference type="GeneID" id="24562877"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106450"/>
    <dbReference type="OrthoDB" id="10491934at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600483" evidence="2">
        <location>
            <begin position="22"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="879" mass="96193" checksum="3C95650C3D870128" modified="2014-09-03" version="1">MKFGFASIVAALLAGVTLVAGKRPLTVDINSQNQPNAIAHVFYDTNRYLKNVYMPRRGEDLTSVVNIVRDGKRKGTQVLYTAPYGQRVYRVFAFGSEVYNLVIIYASDQIKAWRRSGKWFQPIRTEKNYLGRYFTVENVAIRCNDHQFRDFDVMIDTHCDPRLGQFKVYITLHGRKTALERVLAAGDLNAPVITYDDFLQDVALTGYRWPKAFLELVADERLKDKEARFRQMLNEAKLHARHEEFAEDMEFYMVNEHAIASGGGYDIGEPGYIQDEDIRAELDSLDAEEAETHVKHEKAKEDARHAMFDNLTGTAWPPAYEETEETEETTEGGETTEGWETVGGGETSEDEDSADKDEDEASVVIYGPEDVPSEDEDESDVTSVSDSVSVVSTETDSSDDESIIVRGKPKTELPWYKRIFCCSKDTAQSSEVDSPATKKKCPVAVTTDADDEETSEEGESDTETETDSDVSGSVQSGTEDDDDDDDDDDDDEEETGSELTEDDDDDDDDDDDEETGSELTEDDEDEEDEEDDESGKVTECSAVTRVSGSGEGSSQADGSSPTISREEALEVLESFNRDSGWVHVNDTEEEVAPGLVKVHSKWMRVTKTDGEDQVCTIGEDGEKVCVPVEDAAEGSEVGSATGASGVEGGEKSSDVDSEEVAEEHSETHSAVSAHDEDGLSFVDSDEEEEAGEVKSQEDAIEEPVCEVRQAPAVEAIRARKTRAPWFKRVFCCAKDNSEGSVVDSMVDDGTPCPATVAESVNGNETDAEAEAEAEAEAEAEAEAEAEAEAKAEEIAETEDAEQSGPEGYEARRHSSHLSNLDIENGSNVSDSDSVRDPREGGFTATSVGDVDDAASGSRNLRDSAPGDEEGEKDDSEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0N5</accession>
    <name>A0A061D0N5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BBBOND_0105220</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766399.1">
        <property type="nucleotide sequence ID" value="XM_012910945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0N5"/>
    <dbReference type="STRING" id="5866.A0A061D0N5"/>
    <dbReference type="GeneID" id="24562754"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105220"/>
    <dbReference type="OMA" id="FFAYMYF"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDR94213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="439" mass="49556" checksum="1267D1360E1DCBB4" modified="2014-09-03" version="1">MMPAFRRSSSIRDTRGHSKSDNAELGDTCWSRILSNNLAIRIVLGLIIAGGTVFVICLGPIYGSILILLLINMAYYEMVSLYDKVIQQHKQATGEEVSSKTGSVTGKFKKRVRIYVITEAFDVFSFISLETYFLLTTMVGISFPWLLPRLARKHPNIAPICGFVLSYHHLLLFISFFCGVVKFILSLEKGRSRQQFLRFAFIIMALLYVVIQSMMIIANLYYGMVWFLLPHAMIALNDVMAYFFGKMFGRTPLISLSPNKTLEGFLGAFVSTSLVVGMVTPTIMNFQPMVCPVNNFDFTPFAWMTTTCEPESIYKTSAYILPTWAANVLGMKEVLYKPCFVHVMILTLFASLFAPFGGFLASGFKRALKVKDFSDTIPGHGGMMDRFDCHILMGTFTYLYLKTFVRRSNYSPDAVMKVIAKMAPKDRTMLLEKLQEAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1D5</accession>
    <name>A0A061D1D5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766634.1">
        <property type="nucleotide sequence ID" value="XM_012911180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1D5"/>
    <dbReference type="STRING" id="5866.A0A061D1D5"/>
    <dbReference type="GeneID" id="24562989"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107460"/>
    <dbReference type="OMA" id="GEINAKH"/>
    <dbReference type="OrthoDB" id="366399at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="336" mass="38670" checksum="0C01312F283D06AB" modified="2014-09-03" version="1">MSRVKLYFREENTDESTASDVSANDATRRGNDYGTVNSNPVTTQQLVLIHRAYSQFAFYDKRLFDLFFRQMVLLGNKLKPLEIVIIANSMGKSKLHNQAVVDLLCKRVIAQKSGFTMDMIAVFLHGICVPRDNNNNREFFTKIFEAIIENTFEGEINAKHCLTMLQIMTKVKPAQDTCVTFFVNRLLDLRDELSGLETANAVAYITKLDANYAHLSAFVERYIDRYDKDDAIRNAQHLVILFYALSRAEGDTFDKYRNTLLELLHEIPTKYYDPMQVANILRVMATRKIHDVRLLSELSRYVEIKMQTSSRLSRLRCCHAFVNTVCFGCDVNCALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1E1</accession>
    <name>A0A061D1E1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UMP-CMP kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0102600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766118.1">
        <property type="nucleotide sequence ID" value="XM_012910664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1E1"/>
    <dbReference type="STRING" id="5866.A0A061D1E1"/>
    <dbReference type="GeneID" id="24562473"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102600"/>
    <dbReference type="OMA" id="GTQCDRM"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR93932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="204" mass="22468" checksum="010EF6241B647363" modified="2014-09-03" version="1">MTRPLQKIIVVAGPPGSGKSTMSGRMVDFFGFKHISAGECLREEMSNPDSPNRDLIRSYIDAGKVIPVGVTIELLIKKMESFGWGEHVIVLDGFPRNADNAQGWAERMSACTQLEHMIVLNCSIEVCKERILGRASECERTDNATAAIQNRMKVFFDDTVPIMHCLMMAGKCTSLDASGTKDEVWREVTNVLGRLGYQPVSNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1E8</accession>
    <name>A0A061D1E8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766812.1">
        <property type="nucleotide sequence ID" value="XM_012911358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1E8"/>
    <dbReference type="GeneID" id="24563167"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109240"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="137" mass="15433" checksum="275EE4E5203490D6" modified="2014-09-03" version="1">MADGKACYKCGKGCKMLEECYCCPWCCEVCSGDIQCDECRQFYLLRLDYKDPTYNCGSPICDTQCKDKQDTCECKCCLEKRATQAGAFAAQPSSMVIPSTTAYPAVIAPIIVLVIVCLMSVFRVRPFHKVRDCFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1G3</accession>
    <name>A0A061D1G3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0102810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766143.1">
        <property type="nucleotide sequence ID" value="XM_012910689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1G3"/>
    <dbReference type="STRING" id="5866.A0A061D1G3"/>
    <dbReference type="GeneID" id="24562498"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102810"/>
    <dbReference type="OMA" id="HRWKEVK"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="276"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR93957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="719" mass="82485" checksum="B64B0426C89A9982" modified="2014-09-03" version="1">MAENSDAKPSAASAANVSVDDTDRIPRIKRLPARNFDELENESKKHSGAPAVSSDPAPPKDVLLLKQEDPESSPVPIKLVALPPKDTVKVKTEPREKLAITEDIVEPIDRWWEKVDKDFDIEKILKYENQSSHWDYLEHNGMIFTPEYQPHGIPIKFKGEVVPLTPDLEEVATFWAQSIGTPYEESDIYKRNFWETFVGMLPKGHVIRSRRGRLTDCDFSDIKAHLEAEKEKKKENKEYYKALKEETAKREHRYGYALVDWIREKVSSNRMEPPGLFKGRGLHPKQGLLKARIFPGSVVLNVSKDAPVPKVEMFERDGHCWSDVFHDSSVTWLAYYRDSVNDQFKYMYPAAQSKFKGLHDFLKYNKARELKKHIETVRKDYHAKMRSSDMVDRQLGTATYLIDFLALRVGGEKDAEEADTVGCCSLRVEHIKFNSRPNTITLDFLGKDSIRYFQTVTIDEVACRNLAEFCKKKPSEDIFDKINTSKLNDYLKELMAGLTAKVFRTYNASVTLCRQLRRLRVPKALERGVLLEKGGGDEELDKPVSVDVGDVTELISFYNEANRRVAILCNHQRSVPKQHETSMSKMQAQAESIEEDIAELKAYIKYLEGKQDKPFSFKSKAVDAKGNPRKPATRPGMKLESCQRKLEAATKRQKTHAIKMRIKDDNKTVALGTSKINYMDPRITVAFCKRYEVPIEKIFNKSLRTKFPWAMYASADYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1H5</accession>
    <name>A0A061D1H5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0107910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766679.1">
        <property type="nucleotide sequence ID" value="XM_012911225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1H5"/>
    <dbReference type="GeneID" id="24563034"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107910"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28739" checksum="E72BF18556F4FBF5" modified="2014-09-03" version="1">MVYNSLTEIPRNVKECFDWLIAVKGSSRFNTQALGFALHNFLVDMPVGLTRVPSLEMVKRFAKGFLEQKELKQEPHVTCLLAKYRSPMNKTDGMDMKRLFCYNESDYDNVVKSKNISRDEMASIVARVAGNCERFLKRIKTPAQYESAYSSEATWEASCALKPTECAAILVGIAPMLYAGLISLWISSNPELFGEEKSVKEKRLGRVMKILGFEEPGCREDLTRISVRQALVDMDKEIIERIYEIAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1J8</accession>
    <name>A0A061D1J8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766857.1">
        <property type="nucleotide sequence ID" value="XM_012911403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1J8"/>
    <dbReference type="GeneID" id="24563212"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109690"/>
    <dbReference type="OMA" id="YTNDKEY"/>
    <dbReference type="OrthoDB" id="364543at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="615" mass="69195" checksum="73BA2659CF72D191" modified="2014-09-03" version="1">MRYLSRCPHRLRSIPASGNNVSSYVHGFPTVLSGPRNIHGLHFGRAIPDTTRNIRASWFCSTSARVVDGQAVSTWLDNAKTWSDAFRAYQGVTLEHGFPRPDDLTKKSDTVVHNQPKSDLKKRLKLAGRQLAVLVDNCDPYSARSLLACLVDISRTCKCPELHIGIIKAILQELQTNRDRSNRDDSSVDGSALSGLVGAERIKELIKDEKTVALLLASLRAYELRQPPKTVVDDLISVVNVNVYRWKPFQLVEVCRDLAWMYRFCEKERFGALLRKCASLVCEGFGKEGKTATRRQIMTLMKAVSVLGHESTPISTGLNNLISTLIESENKHTEDDVVKQLNLRYRRAKGNVHMLNVALVSGARMDTALVNALLENVMEFCVSYFSATCRVWQLKTEHVGAHDYNSIDPRVAQLLYAKCTNKVLRAPGSLDPANNPEPRYPKLEECYQAVVAALGRLLEAGKLAFCRGLKLCEARLRVIDRAVYKGLNDRSRTFLKAVACFKLEDPQPATSDELYMALRQLGYRPVPLMVQGTFQVNCIDRKRRLYCELCNDKEARLLRDGARVVYNTATDLKMRCLDAAGWRGTIVRMAEWRPLPEGERVALLRDKLSKLSVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2I1</accession>
    <name>A0A061D2I1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767172.1">
        <property type="nucleotide sequence ID" value="XM_012911718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2I1"/>
    <dbReference type="GeneID" id="24563527"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201430"/>
    <dbReference type="OMA" id="KHPKECK"/>
    <dbReference type="OrthoDB" id="365516at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="51204" checksum="3FF294C377CA47E8" modified="2014-09-03" version="1">MHGGCLAVAGRLRVAVAGAIPRGRQRSPAADFSSLAHSSLDKVSLDAHGGGVVSSRHDWQVLYNYAKHLSNDRNELTRSKCITLLLTLSQILLEQSVLRGHGARVTSTYLWNHCTASLAPTPRRHAPTSYSVEPSSLLRYLRYMARLRPYHRLSVLRDGPAPSDDVVSRGSCATTPQGGVGYAGLFSRLMGDDVSPCSVRRSRKVSGSHIGPLRLRSDQLLAHPGIFSYPVYLELIGDEHVAAPPAEGAAAAPDAALILQRSVEQLLDRLRVLYLGHGTRGQQCLVPMFTAVMLYGPKLKLSGNAELDGAYRKLHSSLSNAAISTEGAPPLSFRSLAYLLNSCLHTADTAPICAFAERRISESAELVPLEWLENICFACSKSRYPHDTLYEAMSRHVSAQADSASPVVCLNLLWSFSRVGRAHLVGKALERRIAELGPGAFAHVNPAFLRRAVVALEPHVAESTLQTIRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2V9</accession>
    <name>A0A061D2V9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767134.1">
        <property type="nucleotide sequence ID" value="XM_012911680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2V9"/>
    <dbReference type="GeneID" id="24563489"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201050"/>
    <dbReference type="OMA" id="CINYLNN"/>
    <dbReference type="OrthoDB" id="361409at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="437" mass="48889" checksum="C7E466C6F1677C38" modified="2014-09-03" version="1">MKRSYEDPSLELIGRSAAERRLDRFYNRQRSKLRNATNRDGYAIESKVVEKKELPFQPSESTAASPPSKTRSDEPNARKSVRDILYDLSQRHLPHRGRFAKSVKLLTKLCVGYLSDRANAEYAGLSLDDFFRVFLKLDRIFIVEFGGGVPKDCVELKNVVLEFVESVVDRLLAEADISPVHRELMHLLKLDLCYSASLWYENDSFRFHAIVSQLESHFKRFEAIASERDLSADSEMYNNTPSAPSNPIEASGDQSDSPTASSNNGGESPKSSPSKDGSAAGVIPNSSGASDESKQIDGNSQDCQTTADSPGSTLPSEKELQYLQHQAFVRALAVVFGFCSYPWAKVSIETLFQKVYLRRELFCDTDQQRITDWQRHIKAAKGKTFKGQWSTRPPHGFAGSLTPLGIGESSFQVQDARDEKIVTVHGSQVWSNRQFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D300</accession>
    <name>A0A061D300_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0201500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. BSU subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767179.1">
        <property type="nucleotide sequence ID" value="XM_012911725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D300"/>
    <dbReference type="STRING" id="5866.A0A061D300"/>
    <dbReference type="GeneID" id="24563534"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201500"/>
    <dbReference type="OMA" id="FRHTSWM"/>
    <dbReference type="OrthoDB" id="309851at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012391">
        <property type="entry name" value="Ser/Thr_prot_Pase_BSU1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46422">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE BSL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46422:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE BSL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036363">
        <property type="entry name" value="PPP_BSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="597"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR94993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="832" mass="93136" checksum="64C5E4E9FFFDFAF6" modified="2014-09-03" version="1">MAYQRVVSLQGDLAPARFGHTTTAVGGGKVILFGGAVGGKASVRGFDGASDVGRYTITADLYLFDLVNNVSTKLESENTPSPRAAHAAACVESMQVVVFGGATGGGSLSSDELYLLDLRREKHLSWITVPTTGRSPGRRYGHTMVFCKPNLIVIGGNDGQQASNDVWFLNVEKSPFCWVEVVFPPTLKQPPKRVYHSADLCREGPAATMIVIFGGRSSDNRSLNDIWGLRQHRDSTWDWMEAPVRFVSVPEPRYQHSSCFIGTKLVIIGGRNDNDFNKYVSRATCLSLATQTAVNLGLRHGDARVVQHLCHSQGKEEEQPDNARQFRHSSWSFGGQIYVFGGFSHQTQKHPTCELRAVDCQEAFTDFVKASKDPTGMARLGATGLVMGVPKAPLPQVVPPVKPCEREIRLSSHAHAVHENVSDFSYLVRKISIDKLEEEGRKINKPEARAQLRWQHDDGDTVYDRVIRALLNPNFSNEHVTMSYNETMFPVPYDDVLALCQMVYQIVKQEDTVLKLRAPIKVYGDIHGQYYDLMRLFRLYKCPLEESLAESIGAVGDIDSNDYLFLGDYVDRGSNNLEVICLLFALKCKYPTQIHLLRGNHEDPGINAIYGFQDECRRRLREDCESPYSFWNSVNKIFEMLPLGALIEKKILCVHGGIGKTIHHVSDIEEIVRPITVAPVPKNEQDQKILDILWSDPTDSDSVLGTIPNEVRDPDKVGHIVKFGPDRVHKFLTTNELQLIIRAHECVMDGFERFAGGRLITLFSATNYCNHYKNAGALLFIRRDLTIVPKLIYPSNAETKNAETWDMHMTELRPPTPPRSAPRMHEVNYGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3A0</accession>
    <name>A0A061D3A0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0202350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767264.1">
        <property type="nucleotide sequence ID" value="XM_012911810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3A0"/>
    <dbReference type="STRING" id="5866.A0A061D3A0"/>
    <dbReference type="GeneID" id="24563619"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202350"/>
    <dbReference type="OMA" id="HTITCET"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="109" mass="12454" checksum="798652BEB43CFD05" modified="2014-09-03" version="1">MSIGTPVKLLYEGIGHIVTAEMQNSQLYRGTLINVEDNMNCLLEGVTMVMKDGKTLALEQVFLRGGQIRFMIFPDMLRHAPMFKQSAKDRNKQAVLPQPVPPQFHNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3B1</accession>
    <name>A0A061D3B1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767412.1">
        <property type="nucleotide sequence ID" value="XM_012911958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3B1"/>
    <dbReference type="STRING" id="5866.A0A061D3B1"/>
    <dbReference type="GeneID" id="24563767"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203840"/>
    <dbReference type="OrthoDB" id="5589010at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="392" mass="43669" checksum="113C22C09030EA47" modified="2014-09-03" version="1">MRLDGLMLQRLPTDWQQKIHREFQTKLQLCISNPEEVRKTADFTWQTLLHGVEDRDRLAQRFGPHLGQYVGWRLCGLGVGLRRSGDSPLPDDGLHHGRSGRLPKERYEVDTPVLVGRRASGKRPTGDYGLSWTHRFYRIGRLGRQLLQRYQPAVLELPPRMDADRPEPRMVGGLSNVRRDVPPMGPAGSRHGHGSYGYGPRTDSFGPSSGSSRGGTVHAPSMVSRSGSFRSPTHMSSPEPRVHDPLDETLDNLIMKQRMDRLHGRAGAPLGVLTRSSKFSPAEGDSCSRGSPLSPPYDHPNGYVRSPSMRGAPPDDYHYSPGASPGKVQKICIKFPRCPFGDSCRYIHPAAPLCKNWPKCTFGPNCAFTHPPVPCKFNRNCNNPQCNYQHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3D3</accession>
    <name>A0A061D3D3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADA2-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0108900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766778.1">
        <property type="nucleotide sequence ID" value="XM_012911324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3D3"/>
    <dbReference type="STRING" id="5866.A0A061D3D3"/>
    <dbReference type="GeneID" id="24563133"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108900"/>
    <dbReference type="OMA" id="WITKYVS"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="566" mass="64906" checksum="F4EE9FCCCCCD0206" modified="2014-09-03" version="1">MDAPAKRGFPLAGKGRTAETQPKDLPRTTLKALGPYVQCNICGRLCSRRGHIKCAECKSFNSCVKCFSQGLEKPPEEAHNSSFVQLPENEDAKEHKNYHKYTPVGPNDFALFTKDWSAEQEILLIDGIAKYGLGNWQEISEMVSMTSVGYKSWEECQQHYYNIYLNSPTAPLPDMTSIIHGPNGEPVLVPPSTVVPPKEEPPSGRDAPEKNENPAAVTQTKPANKPQVVGYWPLRGDFDIEYDNDAELILADMEFRPEDTPEQIELKLKVIEIYNSKLDERIYRKKIIISRGLLDAKAMQQKERRCTGEEKELYNILRPFLRFQTVEEHDHTVRLLVRERKLRTRLFQLMIWKALGLEKIEDIAVRDQCNENHLEQKYEERMNRIDTYKDQMRQDDPCRRIERRLRNPQVDHELNNLNVNKIKISDFLEEKEVQFCEALQLPPVAYFLAKRVLLHEVACNPSYTIDDMCGELKIDGTKHGRIFDLLLTLAPRGLSDLPNQVADLSKATLDGNGYLSNSGVASQMSIFSTGQNFQRQAPNKISNYFLQREAACERTRKQHRPNSPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Y1</accession>
    <name>A0A061D3Y1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767617.1">
        <property type="nucleotide sequence ID" value="XM_012912163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Y1"/>
    <dbReference type="GeneID" id="24563972"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205890"/>
    <dbReference type="OMA" id="TAAQECD"/>
    <dbReference type="OrthoDB" id="365496at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="826" mass="91037" checksum="0AB4E99597D9B8AF" modified="2014-09-03" version="1">MQAPNESDPVERTEGSDNMVNMVAVHREDGEIKAFVRADSCDGKSDCIVDSSCDELASIAYKGGIDTGAAGWFSQTMARFNSGCTKDLSLDSAPASTRWGLGVLSEQSGAVKQQVNKLEEHLRKAQGDGTLKPIQHNKVDSIVTELNNPETSESDANSSVLSAAGSTYECTFVQPGTHRFDVQKIEEIVDKLVDAKLCSFRETYDEEIRVMRAEHEQMVKKAANEVLEEVSMLISSESSKVEQKISTLLVQKVNEDTLNARIKGAIKEAKEAVQLSIQEGIDEKLNKVLHETRDAMNSHMASVERNVEDKIDDVVSRITSCEEKMRQISDDIVGNIEASIAKQSDEKVEQVNEQIRIMRSDLGEIHSKIEQANQEATRFAQRIDAFYSEVDSMIQKGGQNIKDELCANFDSKWSDVVMKHELDDIMQKVKSLGAEIEARAVETAAQECDGKLGVFSINVEDKLSQDFYRIIDDRVQKLNGDVIKQVSNAVDLKLRGIKEPQNEDDTAMRDAICKSVQIAIMQDVAAKVDAIAKDVHETVELKVKDAVLNAAAAFKTENATPDVGEFLINSPPLHHASNEITTCSEASNECERIIERFSQVLQQSELQINAVVKTSSTLQHLNEKATVIIEQMRQCIDSSVKQTMVDSNVAAETIKNGRGINITAPREIDLVGNPINDGKCITTRTSHMHPLSTGPPIGPPSSKTVTFDHFTPISNSIRAPHLNEDVHPGIFSKLLCGYSTSPSHNNVIDNRCFTAPMERPNTSHYRTPGNTNSERSLTEPSNPIEVKYVNMNGQVIKVTQRHLKLNQLSAGQQAAARGAFYSPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Y8</accession>
    <name>A0A061D3Y8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0465 protein C5orf33 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766953.1">
        <property type="nucleotide sequence ID" value="XM_012911499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Y8"/>
    <dbReference type="STRING" id="5866.A0A061D3Y8"/>
    <dbReference type="GeneID" id="24563308"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110640"/>
    <dbReference type="OMA" id="GFKDDYI"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF5">
        <property type="entry name" value="NAD KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="538" mass="60101" checksum="D405CB6A456D0A08" modified="2014-09-03" version="1">MMSRCVRAYMGALRLGGASSALSRQRCDSLHGTHRPLLSLARASLGHANDRNTQPPISSELQDKFKQLKIKEVLVLEKITKYDLERKNGLTDSEIRERFPLAYRTHRTHLGIMDALMRLLKERYRLRTIAVKAQSHNLVLSDLERSGFSLDLIISAGGDGTFLEAAALLPPSQTSLQRPWIVGLNTDPERSVGAMCMSYFKRGGMVFRRYSGEQRTEPDDSPKQNMIRFTESDALIRKECASDTISEKEWNNLTKASFCDTHHDGSDTRDHCTVISKHVANIYNITYDDYVGSLLERLIVNRDYVPVARQKIRIKMFKRQSAAEQEIVATKGDSTFIEDNLFCGTESSFTEDDLDAEACASGDGVIPYGAVNDVIIADKNFGKTFYGLVQVDALPIIRVKSSGVLVSTGTGSTAWAYNMCKMSMDNGFRLLNHLINHRSFPKEAAKVIDAKMMREAIEEHNAGLVFDASQSTLKCIIRESISDTSTVDATSFMGRQVKLLSLSKNARLVIDGSRIMKVDYGDVVVLKTFESDTIWSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D402</accession>
    <name>A0A061D402_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206190</name>
        <name evidence="4" type="ORF">BBBOND_0206270</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767647.1">
        <property type="nucleotide sequence ID" value="XM_012912193.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767655.1">
        <property type="nucleotide sequence ID" value="XM_012912201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D402"/>
    <dbReference type="STRING" id="5866.A0A061D402"/>
    <dbReference type="GeneID" id="24564002"/>
    <dbReference type="GeneID" id="24564010"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206190"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206270"/>
    <dbReference type="OMA" id="QINSIYW"/>
    <dbReference type="OrthoDB" id="366097at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="182"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="281" mass="32074" checksum="60D7C8C0249A3199" modified="2014-09-03" version="1">MPGLGLDAGYESGYESDNADAEEVTEADVADLMKLIHDAKQGKLGPMWKKEMMAAEELYLRRRAALRDLGGTADSDEKPNVSELLKEQNDVLDEHLNAMFDLSELRHPTEEEVRRNLGEMRPEDEGWTQDDAGLQSTQESRDAQYMRSLTQGKLRREDLSNLISGFYRQKGILNEPVVVTALPPFEVSWRQHSRYFDLWFPCISPEDREDDYAVTFMPRELTITYNGKAVSRPLRGKVDVDGCFWSIHDMEGRGNVVSVVLLKSAPRYSGTWEHLFRGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D447</accession>
    <name>A0A061D447_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766993.1">
        <property type="nucleotide sequence ID" value="XM_012911539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D447"/>
    <dbReference type="GeneID" id="24563348"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111050"/>
    <dbReference type="OMA" id="EFVWNLY"/>
    <dbReference type="OrthoDB" id="360724at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="658" mass="74981" checksum="9B13777EBC76841A" modified="2014-09-03" version="1">MEPVKVLEKIETHPVDCPATDAAATDDSCGLIFAGASPEESVKKLFNPPLKDGEEDAEPGRTKRPREESTPVKGRIKFDRASISRVCPNVEFPFSPSESDLLFIDESLELLRSCFDDLPGFKLIREIEATGSEYGDPEERFMLLVDSFFAYMDSEETPEVRLEGETDCTSSEQTPSVDVDVNYDRQAFRELLRCLVLWCNWVFQMHEHTKDALSIAQSTLQHNTASKIVDTALGLKQANRNMAFYSNMCSRLTAVLRERGAKYDQIIKDTLCKVHHVRFNVGRVQQSSNASWERLSAVLSKQTTAENEIPMDDAGDDYRRNINLVRNEMRLRMKKKGSCDSLTKACDMLTQELASINSKRQSLVTRMEQAMRQVRELTTSYRADAYVESLKLTDSKKLPTLLHNFLSRMQLRAIATPNRDVVFKVFREGDREYGLHMTFAAPRDVLMPSADAASIVFPLMFLATVDERGLIRIREPRFPFPGSAVCDSTPRADTTPRRMECVSIHSESSMSTGSDSPKETINVDGMVLDTFTALDKELPQHFCERLDWWYDIARQHVWNCYLADGYRRGKCSSISMLPQELRRSHSSQYTSRSSGWILSNKCASVRMRLEFTEELEPRCTFSEFEHYEPLYLESTSPIVDLVRDRFTDANEDKIAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D474</accession>
    <name>A0A061D474_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0205310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767559.1">
        <property type="nucleotide sequence ID" value="XM_012912105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D474"/>
    <dbReference type="STRING" id="5866.A0A061D474"/>
    <dbReference type="GeneID" id="24563914"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205310"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="478" mass="54953" checksum="B28812876260F74A" modified="2014-09-03" version="1">MLHFVSQLHDITHSWKLKKGLVTSHDVNCIIKDHASRGDLKGVLSLLSELRSNGFAITKENYNNILIAFQNVYTADTARYICLCLIADGMSPDLTTYTFLIKAHVLTGDVSSAFTFYRKMERAGIRADLTVYTTLIDGLVGKGLLDNAWRLYGYIRTWRLIQPDVHLFTTMIKASAHSGDTHRAVSLYDEMLQLNISPTSHTYEALIHCCSREKCYAQRCLEFYDRMRCNDTPIRHDTLIHLLRACKNIGNTRKAMDVLRDASDQGINIDENILAAAINVMLNDSFESTASYFRKTEGVRKACCLVRSLLTLKKVVTTKVMNTIMEVYENAGYYDYAVAAYNYFHRLGVEPDHQSHTILLRIFGEKLRDPCRFFAVWQTVRDNIKPGREFLNVALDMAMLSNSAKRTLYILEHMYESKTHPLPELAATLHIKGRNIPQIHIMINRLFCLQKSLSYDKKQKDHQMMQTFLDENRLYYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D477</accession>
    <name>A0A061D477_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767033.1">
        <property type="nucleotide sequence ID" value="XM_012911579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563388"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200040"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1732" mass="194012" checksum="580C006752F69BEB" modified="2014-09-03" version="1">MAFLLGVLGAVKDDENVKHYYPVEKMTETLQKIKNSMHNPGGLSKAVMAVSTALGEWDGDLQKKIDKVVKEEGEGTLKALKRKIGENIAAVDKLKSQSLDSVVSTLATTVFDGLDDNVNAVKEAIKKLDGPLQMKVMSDFEKIKMEINHVTKNAKEDKWRMEKLCENVNKVLDKLRHAVHMTTDNEIRRISTTLADNMENIQGHIGIVDEMLKKYVEHLTVWIKNADQTMIDALERVEIILQQVKDTENARTKKDIQEAIRQLTLKAQSLYHAGRAADRLVKELVPKANIMITGLEKVYVNKLWKLKEDVNFAVQDVRKKIGMLGHQLGVKTESDNIKGIMKHIEEEVKFIKGKIGEPMKVPELDDADDSIYKNWQKIKHEVKQVVDSMTGVEDGEITGALKLIAKGVTDYANGFGEEGFSSNVLTEWIGDILKDKDESIVTYKINQYVRLHKNVSQMTDKDDEAVKDAIKKHLPSHIYTEIQEAAVTHLNRSTVGNIADRFQEFADHVELQLKNHLNFSLGRAAQQIEEQLGLTKAKHKYRHNIEIIIRAIVKSLLNNFKQVALELKRFAKTSLINRIESAIPDVEDLGKQLISGNPGEKVDKALEAVKPKIETLQHQLEKATQPNSLGDDSDNAAAAIDVAIHNVTKHPFEGIVASGDGRLLNDINGRLDAYIALNDTMGVLRTQTITALSQIDNAHNDVLKLFKDVTSNIAKLCATIEKASDEQPGGLKKMLGDFRKERIAMVNNRSGLQKIKTDLDTLQKDQLRKLDTAVTNVLHSTLPEAVENCREAIQENIREEVEKAKRDIKQDALKRYVKSKINDLKALGTFVEQRRALMAKTIDNDLKSGIKGFFKNLNADIGEFNNLNADSELPDGASYAKTFFQLLSSNISSQPDMMSFTTIVDAIHSPVDQLLSGLESSEHFDSTFTNNLDTLENAIQSLVPTGFSGPLSPLIDVLKEGITAFVKQLNMAYVSRYSGTSIQWNETENYKRLTADATNCAKAFLTLIPVMCHDVSDLRSKCVVSWSELKTNLRGKNNPLGACLQDAGYKVSESEAVHNGVLRNTISGQTVNEKLKRKTTDAEKLEQLKAWKTSNNRHGDGVTLLDLFDYLHDCLRWYYEVCHLGTLSSKKHPRSIYDMLQWLSGLSYDPVHQELALNGFSDLFEKPEKDESDAELSLSDKDPDTLEAYPENVTATKLSNSLRDVCAYSETVLVAIQGYGHAGGRYACDFNSNADSFVYPADPAKCLEILADVLTRVYEQLCFLLVQCSREYEANSWRDCYYGRGVGGSSWTCNTKQCGNQIGDQTCNQSADQMANQNGDQKDDQQPKCGLKSPLQSFLEDGLPGFIPHTFDKVGCKLECTVSKHRGLPCKTPMGFNDISNVASHTKQGAHLTKVLYDFCGHMDSPLVKLCGNLVCLLNRPPQTLSDMYAFYYNLLHDWNGKSRGAIDVRKHKMTAFNDAVTRANFGVPYPELNVNSIITDHKSNNHTTGDLLCLYSCNSTSSLTATCGRYLQPFGMNTWTVFSEKHADKYLSWIVYITEVFYNLLEQLLKECCQNCTSSQSRCNGKVCPKTCPVKYTSDGTKSQSVSTIHHTKDCKSIAYCPSTRPTLCKYGFVFKSLSNMSGNSGESTKRTCKDLCHALQNVLLKGKVLGEFTHVTIPEFLWNIRQKFFWMTVALWLLSLLYLIHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4F0</accession>
    <name>A0A061D4F0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0207660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767797.1">
        <property type="nucleotide sequence ID" value="XM_012912343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4F0"/>
    <dbReference type="STRING" id="5866.A0A061D4F0"/>
    <dbReference type="GeneID" id="24564152"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207660"/>
    <dbReference type="OMA" id="KYHILFF"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="51"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="254"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="684"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="818" mass="90455" checksum="90AB18E2091C4693" modified="2014-09-03" version="1">MKSDSAGASAKKKAAGGTGAFGLLGLNKTLCYALEHRLRYKQPSAIQRKTIPAVLQGRDIVCIARTGSGKTVAYLAPIVQMLESHSRTVGLRCLVLLPSRELALQVASVLKKFINFSKQADALRSATLIGGEALESQFGALTFNPDIAVATPGRLSQHIVEKSIELNLLSHFIIDEADKLFEMGFLPDVYRIFSMLPEKRQTVLASATLPSEITDFVKFGLRNPVVAQVDKDMQINEQLELRFIYTRTEDKIAVLVKLLRFSEENERTIVFVATKHHVEFFRALLAATGLTVSAVYGAMDMTARSQQMSLFRSCKTKVLIVTDLAARGLDLPMVDCVVNFDFPHSSKLFIHRVGRTARAGRQGTALSLVTPYDFAFCFEILTVIGRKLLVSKEPVVGNDTCIIGTVGDISVTMEKVASILQSDAEVESLKKSMDASYNLYYKTRPKPSKSAVDQSQGHLEALGGLNVVANTVHPSYAGVKSHGASAGAESGASTNDGPAEDDQEQGVSDPKQDADAASKNEILEFLHGFRPSSAKTTIVTTLPASSIATMERAKHYSRQFKKLDSSVPLPVDTSTDFEAVAIPRGHDVAPKQDFLVPSAASTAAQDELRLPNITLNITPDSEELMQKSRFQRKQHWDPKKKKFVQVTVDSITKRVIKDESGQKARGTVENKDLLKKWMKTTRKRIQKVGEQEEAPQRKKTANVVKFDDDDESGGDSDGDGDGKPNYDELIRMFPKHAATLESAKMKRPLTHKQKRTLKRLTTKPDFEKMRPETKGKKSAKGKKRTRLSQQEFRKKVERKIASKGAPRRSKLIVRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4L5</accession>
    <name>A0A061D4L5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rpn2_yeast 26S proteasome regulatory subunit rpn2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0201490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767178.1">
        <property type="nucleotide sequence ID" value="XM_012911724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4L5"/>
    <dbReference type="STRING" id="5866.A0A061D4L5"/>
    <dbReference type="GeneID" id="24563533"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201490"/>
    <dbReference type="OMA" id="IMFGRQE"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="6">
        <location>
            <begin position="783"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="844"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="880"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="913"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1006" mass="108958" checksum="4E0CCA9B45ECC05F" modified="2014-09-03" version="1">MLLDSGSDDSARAAAAAGTAPSGEQLLTRISSAEPVLALLHERDDASRELGLLQLDSIVDTFWPEIADSLPTIEYIYEDPHFRARELAALVASKVYFNLQDYAKALHYALAAGDRFDPQGRSEYANIIVAKAVDEYIRARQEAQDGNTPRSNSSLAAASQEPLEALVTRLIAMSVESGDEHHAIGIALDARRLDLLLRILKDSANCCELVSYTMGLMDGVLNPDFCAPLYDSIRDILLAMPKDMLANQYPNLVTCLYKVNNHEQMAQLLLDMVKHGDHLQAYQICYDLVDIGDQKFLKALKESPILSVEGNFMVERVKRILSGTSTTELHLQFLHRKNHTDLLLLEHYMNSVDQRNSVAHNAVVLAHAIMQAGTCCDVFLRDNLNWLAKANNWAKFTATASIGVVHKGYVKHYKKVLASYLPGETPNSSHAYSEGGSLYATGLMLSNRFDPEAAEMMLGHLRNDSAEEALHHGAALGLGLVCMGQCDPAIYEELKATLYRNSAVSGQAAAIAIGLLMMGSGNLEVLDTLYAFCSDTQHEKIVRACALAISMVLYRCEKNASIMIGKLTHDNDPVVRYGGMFTYAMAYCGTGSSKALKELLYAAVSDVSDDVRRAAVIALGFVLCNTPEEVPKVLKLLVASYNPHVRYGAAIALGISCAAFPQPDVVRLLHSLSSDRSDFVRQGAFIALGLVLQQSNAETSNDVMQVRDLFRSVASEKHQDIIAKFGAIVGAGLMDAGGQNCVASLYTGRGNMRREAVVGFLMFAQYWYWHSFMHFVCLTFQPTCLIGINNDLQIPTGYKVLCTAPPKTFDYVPHITDEPSEQKKAEVTAVLSISAKRRAWLTNARSSDQLGGKGDKGESKSGVDGGAAPTSERQPPGMEASSAAGDAGQPAQAAPESGTADLSGDVVMANGDEQGASSALGASAGEKAAEQSTGVPTLLENPCRLIPRQAAHCSVPPGSRYVPAFPERRQGIVLLRDCAPGEPEEYVACESEQPEAPPFTPFEYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4R8</accession>
    <name>A0A061D4R8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase D active site motif family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767228.1">
        <property type="nucleotide sequence ID" value="XM_012911774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4R8"/>
    <dbReference type="STRING" id="5866.A0A061D4R8"/>
    <dbReference type="GeneID" id="24563583"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201990"/>
    <dbReference type="OMA" id="WITTPYY"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09110">
        <property type="entry name" value="PLDc_CLS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="500" mass="56123" checksum="47E46BC0ECD5789A" modified="2014-09-03" version="1">MIRRSLLGDSTRDEATRINEVPVSHRWVFISSEIRRIISGSLLRTPTLATDSITPEVTKWTRILSQLNERLGRMSGGNDVVCSNGVPLGDQTATEMLNAINSAKRRVWMEVYIFDDSPLAAQFVRALKNAAKRGCEVILIIDYIGSFGFPSLFLNELSKHGAQVIVFNPFMDRQLAIGTMPFRNHKKILVVDNDIAFCGSMNVSVDSTSSKMGGNGRFYDINLRIRGPAVCDLANVFKRTLAMTSYKVEDLQPCVPPSPIEDGVIVQVLESDMFRLSRRNGIQSSLATVISNIEHAVKAEQNVYLTTSYFYPPGFLRRTLLSACKRGLQVHMLLSGNSDVPGDINATLHVLRKFFRKRFEGANDFKVYMTTKEHCHGKCVVVDDIWSCVGSFNWDRWSSRRNLEVSVGILDPSIAVKLKSLQMEKEKEAVEYTRADSLNRPTLLKIFDSLLYKIVRFSGRNCFDGLSNDGFKSRFKKAFIRTLIDDKAAETIALCNMAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Z8</accession>
    <name>A0A061D4Z8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0202790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767308.1">
        <property type="nucleotide sequence ID" value="XM_012911854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Z8"/>
    <dbReference type="STRING" id="5866.A0A061D4Z8"/>
    <dbReference type="GeneID" id="24563663"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202790"/>
    <dbReference type="OMA" id="ICCKYRK"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="283"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="446" mass="49938" checksum="7F503E741B9BE974" modified="2014-09-03" version="1">MEGSQQIFDADWDVRSTQEHNASYWSGKASMPSIALLKSICANGGMVEFEMEPSGVLVCHIPDHKVTVNMLDPSGLRSRRGEAYVIGDIVLLLCIRREDYTYSSITKRGFKYINVLERDRIKSILGDPDTSPDLLEAKARFIPISGTGSSRVTGSRNDVSDSGTSTQVGSKHMIDVVMKKVEDSWRAFMHDTSQEDDEEYRSAKKRHYNMCVLAAGLMERPLRTRTSVIMAHGEGFERVLQKLEAAQANKAASKARDAPKSVGSVLRTQSKLRVLDEICCKYRKKPVIIVPSGAMSIVARQNIKQLLEDHQFVDPQESLRANGAIMSGLPMNAVEVIHTISGRTIKFRVVESSYTTKFTTTDWISVVCVILNIKGGQWQFNGYPFESFVDLFMTMKGALFAYDTDNIPADMGNWDLKRAFFFNRGIGKYTQQKGCHKWAGDRNKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D519</accession>
    <name>A0A061D519_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S18, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0209340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767967.1">
        <property type="nucleotide sequence ID" value="XM_012912513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D519"/>
    <dbReference type="STRING" id="5866.A0A061D519"/>
    <dbReference type="GeneID" id="24564322"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209340"/>
    <dbReference type="OMA" id="RKTRCER"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="154" mass="17460" checksum="3A9533A7B05F9433" modified="2014-09-03" version="1">MAIQITASDQFQHILRILNTNVDGREKITVALTAIRGIGRRMATVVCKVAGIDVTKRAGELTNDEINKVVTIIGSPADVMIPAWFLNRQKDYKEGKNMHNTANMLDTCLRDDLERMKKMRLHRGLRHYWGLRTRGQHTKTTGRHGRTVGVAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D573</accession>
    <name>A0A061D573_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0209740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768007.1">
        <property type="nucleotide sequence ID" value="XM_012912553.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D573"/>
    <dbReference type="GeneID" id="24564362"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209740"/>
    <dbReference type="OMA" id="RKQEFNH"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="9">
        <location>
            <begin position="1495"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="3885"/>
            <end position="4220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1440"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1540"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2411"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2660"/>
            <end position="2679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3006"/>
            <end position="3025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3129"/>
            <end position="3148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3364"/>
            <end position="3392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3450"/>
            <end position="3502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1440"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2418"/>
            <end position="2451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2460"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2527"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2599"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3006"/>
            <end position="3018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3129"/>
            <end position="3143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3484"/>
            <end position="3498"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="4187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="4220" mass="470871" checksum="3081C57EC4560A78" modified="2014-09-03" version="1">[encoded data, 4220 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5C8</accession>
    <name>A0A061D5C8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0210590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768092.1">
        <property type="nucleotide sequence ID" value="XM_012912638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5C8"/>
    <dbReference type="STRING" id="5866.A0A061D5C8"/>
    <dbReference type="GeneID" id="24564447"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210590"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="197"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="354" mass="38825" checksum="689163EA624E04D8" modified="2014-09-03" version="1">MASPRKVCVMGCGNWGTASGKLVAENAARHPEFEDKVRLWVLEEVFEGRKLSEIINTDHENKKYLPGIKLPHNLVGVPDMKECVQESDTFVIVLPHQFVKSTVKKMKEMGPLRPGSICISLVKGIELTGRDVVCFTETIEQELGIPCLALSGANVATNVAMEEFSEATIGYKEKEHAVIYQKLFDRPYFKINCVPGVAAVQVFGAIKNVVAISAGFCDGLGLGSNTKAAIMRIGLNEIYKFATKFFNEDCNRVVFESAGVADLITTCIGGRNVRCAAEFAKHHGKKSWTDIESEMLGGQKLQGTSTSEEVYNVLKANGIEAEFPLFVVTYRIAYEGADPADIIRQFSVEAIAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5H1</accession>
    <name>A0A061D5H1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767463.1">
        <property type="nucleotide sequence ID" value="XM_012912009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5H1"/>
    <dbReference type="STRING" id="5866.A0A061D5H1"/>
    <dbReference type="GeneID" id="24563818"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204350"/>
    <dbReference type="OMA" id="DESEMQF"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="162" mass="18109" checksum="CF1BD664BC632BA5" modified="2014-09-03" version="1">MASGNNSVVYLAVIGEQRELIVSRAFGDADEAQLQLSAYAAMDVIQEKMVIQHYSATPGEQSDPYLGFITPTLLGEEFYKVHAYMAATGFTIIAIFDEHDASLESIRQVLQSLNSRIAAQFFEKIHILFANTMCNPFMSMKFHSPRFYASLEKIASEFATPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5L0</accession>
    <name>A0A061D5L0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0204500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767478.1">
        <property type="nucleotide sequence ID" value="XM_012912024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5L0"/>
    <dbReference type="STRING" id="5866.A0A061D5L0"/>
    <dbReference type="GeneID" id="24563833"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204500"/>
    <dbReference type="OMA" id="DFSHECL"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="505"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="764" mass="86129" checksum="B11FD1109AF62CAC" modified="2014-09-03" version="1">MLSPARFAGHEQHKIVPPKNAGVVFDSRAAPIRFALPFKPWIFICFAGFSGAMCGSLFFRKCVLRKNPPNPNNLCSPRETPTKDHLSNIHTRRMSSRRCALLLLILLLRFTDCIRRGQRFDAAFVRLTLLTAKTNAHDYLSNDDHRKRTTFGDETTGIFNRQNSVTSALRSSCIRADGGKSDLEAQIGDGNDAFLDISVDGSLSVPDGTSDCGTRNSGDDYGDGNGDVVTADDSSKRIMIPYTVNYPVNHEDLRELNADERPEKAKEKLDQLGFFQALDKGQEVANTQRPAPQEATDSYSLTMSTLEPDSKVWECMKTTSMAQQIGTKQASKDAVTFQCPSRMDYESLRDQWIVGRARIHWFPRYFGKSLGELSEHIKMCDVILDVRDARIPYVADSDFLLNVYNNMFTHKPKVLVFTHADLAAIKGSEEWGTYYRIKNFWDAQQFNRNIPEQNRKPVTPVIFVDAKNGISCIVRLKKLIYKLCQRVNQRRARRGLAARPLRAIALGMPNVGKSALINRLLGRHKARSFNAAGVTRDIRLVRLHPQEYREAAHKIIDVIDTPGVLPANLYNMAFGPAKGKSDRKRNRLLGSMYFNLPQTYVHGGHSKTGIDAKQAPLERNVWLIAAANQIVEGAYDNDQAAENLLEQALEVYKRKRSYVELPRILKRIGLDYTPSILEMHPADFSHECLQTASHKHHGGDVNAAASRILADFRRGYYGRITLQTPPSEIPNRRRTYPEETSEGHTEASSRPAKREYAPGIYEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5S1</accession>
    <name>A0A061D5S1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767538.1">
        <property type="nucleotide sequence ID" value="XM_012912084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5S1"/>
    <dbReference type="GeneID" id="24563893"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205100"/>
    <dbReference type="OMA" id="PLTHITM"/>
    <dbReference type="OrthoDB" id="365225at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51016" checksum="2241EBCF8D41A796" modified="2014-09-03" version="1">MRNIQGSCTFSASGRALFRRQSRHFVFSTCPVLANDRFTDTFKAGSVLCIAGPCSSGKTLLVLHILADILSSYGMCEQAVYLDFDLSLDLMVLKQIVGNQIAEYGLTGAALEAEVSSSFDRLVYFPVYDMHDTHHLFVALDAYFQSSDSRVLVIDSILTKSGTFEDELVAKCLQLLMRLCRDHGLLMVYTKREGGSFTLPFNVATLCPHDLLSEAHASLSRYNADLLRNILTFGLPVDWIPLGERVAKRPFNEMQSSSQLTRKRSIDSVRAFWRRKKDSFDVGCGFPHVGGGRSDNSGVMLCCLPCRRASIDGSGYIGCVYKINSPNSPTDTFTTAMHTRKCWQNARGIRRLLPVWLGIWTSEDEDDMFLADDCSEFQEVRTQDIVMSEQLMMESTENDKANAVVRPCTIHSRNLWSPLTHITMDDNTLHSLKFGLFRIGEDTALRSQLFCLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5S3</accession>
    <name>A0A061D5S3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTPase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0210560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768089.1">
        <property type="nucleotide sequence ID" value="XM_012912635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5S3"/>
    <dbReference type="STRING" id="5866.A0A061D5S3"/>
    <dbReference type="GeneID" id="24564444"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210560"/>
    <dbReference type="OMA" id="KNDMNDN"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="entry name" value="GTP-binding protein OBG, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="Obg GTP-binding protein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="339"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="8">
        <location>
            <begin position="484"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="565" mass="62760" checksum="9ABA255C9DC3927A" modified="2014-09-03" version="1">MIVRGGRGGKGNRYYMSKFNPAPYVCERGEEGVTREIVLNYKIIGHVALIGKPNSGTLGVCSFAHTSTGKSSLLRCLSNARPRVADYAFSTKFPIMGMLDVDEFVDRSAEMDNVIDGDEPDVVDRVDDLAVVDTTNSEEIEYAPTDSTYSDVINDIDGFAADNDKIGDISSDNYVMGEETDTRSDDADSVDANRSNSQSSAMMCMYGYRCSPQLQSRSDDAHDDMQRHVAGSSAADRVHSSEDGGTVLRGVHVKRVSPQSVPGNPSDSASDTYYGYSSSYESAYDSEDDSTMYSNGSHDDHGSEDGCGRECTNGSFDTGANIAEMCGLATGDDASSKRRQLTIADVPGLIEGASAGRGLGHQFLKHIENSNVLAYVVDGSLEDPLADYHDVRNEVGLYNEALLSRLELVLINKIDLIDESRVRELVDQFKQECNHDRVYAISAKTRQNMDEIKKTFANIYQEHTDNSNRNHEPMDAAIDDPNDFRKLNPRKFKVEQVAEGEFRIKSDYLERKIPMMRFEYRETLDKLRRILRTNRIHYKLRRMGVKAGDTVHVGGMSFCVDELAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5X8</accession>
    <name>A0A061D5X8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767608.1">
        <property type="nucleotide sequence ID" value="XM_012912154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5X8"/>
    <dbReference type="STRING" id="5866.A0A061D5X8"/>
    <dbReference type="GeneID" id="24563963"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205800"/>
    <dbReference type="OMA" id="DTQLWEI"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="71"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="235" mass="27427" checksum="811D04A19AC7448A" modified="2014-09-03" version="1">MPIDYSKWDHLELSDSDEENKPRVIKLDRSQRIELGRDGYNIVSSTASAADPREIAAQYKFWKDHLKNGSVVARSHAFAQDRYDVCLLIALRDDARHGLEVEVTESHIRILAKGLEIFNKELFAKVKSDDDYVNWQIVRKYVDWNALESYCRNAGRGSLGTHMVFTEFYEQAFVEVDLKKQNNIEDCFLWWPKAFKDDVPSIRFETQGGTKFKESWNQAHEAFKQRVKSFEKVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Z2</accession>
    <name>A0A061D5Z2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0106380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766515.1">
        <property type="nucleotide sequence ID" value="XM_012911061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Z2"/>
    <dbReference type="STRING" id="5866.A0A061D5Z2"/>
    <dbReference type="GeneID" id="24562870"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106380"/>
    <dbReference type="OMA" id="AKCHFTA"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="82"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="159" mass="17128" checksum="53D1CB59C47E4C8C" modified="2014-09-03" version="1">MIEESFEGADAGASHTVPVSAGSIKMNGFVMIKGKPCKVVDYSTSKTGKHGHAKANITGVDIFTGKKYEDVCPTSHNMEVPHVKRTEYQLISVDDDGFVSLLNPDGTCKDDLQLPRDNDGSFDEVSKQIQSLVASGKEVLVTVLSAVGQEKIIQCKELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D609</accession>
    <name>A0A061D609_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromo-helicase DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0106580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766535.1">
        <property type="nucleotide sequence ID" value="XM_012911081.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D609"/>
    <dbReference type="GeneID" id="24562890"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106580"/>
    <dbReference type="OMA" id="ERIVTHY"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="492"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="579"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="687"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="996"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1277"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1615"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1287"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1683" mass="193797" checksum="FE5BDED9902D161F" modified="2014-09-03" version="1">MENTQKTLAADGQAQAHEPVVKTEIKQESATGFKPPDVGQSQQQPFQVADPKQAYYQQQMMYSRMMGQMHQQNMISQQMTPGGPQHVVQQQQQPQMQQGQVPQGHGVAYPGMMRPQTGMQQQHTQQGAGWFYPMAMYNQQMMSGGQVVHPQMMMNNQAAVMSKFMPQYNAYMNRVQQSAEIKTERPAVPTEVKKEESVEKVQNSVSENAAQSIKTEDTNGEKPKYHAEQAQAAGANYTARYGMQPQYGYGMNMPVNPMMYYQQQNRLVVGNAIEGIPALRMANSRFQNVTQMLDALAQQPKKKQQRKSQPRYGSEDTDFKSVVNDYFTTDGRNDNSDDEFLVGRSVKDVDTTAIRRSGRARTKNSLYAEYTESDADTWEEPSVRHTQVVPKMPRKRRETGMQSRRTQQRSTANPYSKNNYVTYDDTDEESEEYANVGAADSGPLALRHRKRRVNYAEMEHEQWSGEDGEDAEDEEDAEERERRQNTQQELQGGIDRVIDHRVNEEGVTEYLIKWQGYAHIHNTWDVYEALKDYGGIKRLDNYIKKLKQRESRSLYMTPDEIEHENIDMELQRRIDEDALKAERIVTHYVDKENSVTYYMVKWRSCTYDQCTYEEEQVMIDHEFNHLIQEYKEREDRISGESAKKMPWNTHSLSLTKFEPYQETPTFLANYETRKLRDYQLIGVNWIVNRMKRGLSVLLADEMGLGKTVQTITLIGHFLYREGLIGPYLVIVPQSTIDNWMREFETWLPKANVVCYYGNAKAREIIRTYELAKVHVPGKGERYRCDVCVTTPSIINAPLDLEFLRRISWQLMVVDEAHQLKNRNSKRFVELRQFMADYKLLLSGTPLHNNLEELWTLLHFINPQIYPYYEEFRRRYADVENAAAIGENKQKQLLALQQELHEVVLRRVKKDVEKSLPNKVERILRVELSPLQVEWYRNILTRNYDQLAKNSGGSRSSLQNICMELKKVCNHPFLCYEPEDRQTWSQGLVYGSGKICLLEKLLMRLKERGHRVLIFSQMVRMLNIISEYLTLRGFKHQRLDGTMGREVRKKAMDHFNDPNSDDFCFLLSTKAGGLGINLTTADTVIIYDSDWNPQNDLQAEARAHRIGQTKTVQIYRLVTKDSIEQTILERAKTKMVLDALVVQGLNKKSNAVVLEEGGSKCGFSREELAKILKFGASKLWSKDKNNTLENASGEENLEIDLDKVLEEAEVTNDNDGLASDLLSTYTNITEFRYEPPEEQSEISSENNKEFWDATIPLEERVKLKKKKEEELMVLGPRRTRNKDLGGMDNDDFSDDEADVDFQPKRDSKMNWDNTDSQGEKGVAKRRGPKRSRKVVLTIKDKVKIYRSLSKFGVPEMRLKDIHEDTKLTKVDPRVILNECQNLIDMCKTKISEMGNDDAMELSATSSAAMKRASKAVKAFELGDAKISPLEFIKKLKLLECLEDWGRQQAGPGWATSDQPLELPTEVLEQFADVKEPWAMEDCVNLLKLIHIHGYGYWTLYCNDKNLCVGALSGMKHDKAKFKAQKLLKALYEHRSHLVKSKLPDVPMNTGLPPVPYRKNSKLEELVVDDDAVVGKDDGKENAVELMLTTGKPLMREHFAAAVKWSLRDGRDRLKRLKFLKDQNAQGEEFLKEVEEALPELKSLIESAVGQCKDPTTGQKLKAACLRFVSKFTLLPIEELEKEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D660</accession>
    <name>A0A061D660_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM5</name>
        <name evidence="11" type="ORF">BBBOND_0107180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766595.1">
        <property type="nucleotide sequence ID" value="XM_012911141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D660"/>
    <dbReference type="STRING" id="5866.A0A061D660"/>
    <dbReference type="GeneID" id="24562950"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107180"/>
    <dbReference type="OMA" id="YETTPQG"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000041">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="9617" checksum="4B2B7BC40E43E899" modified="2014-09-03" version="1">MATIESSACYLPLALVDKCLGTKVWIIMKHEKEITGVLRGFDDYMNMVMEDVTEYTFTDSGIQTTELKDALINGNNIAMIVPGGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6K2</accession>
    <name>A0A061D6K2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pre-mRNA-splicing factor of RES complex, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768374.1">
        <property type="nucleotide sequence ID" value="XM_012912920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6K2"/>
    <dbReference type="STRING" id="5866.A0A061D6K2"/>
    <dbReference type="GeneID" id="24564729"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300930"/>
    <dbReference type="OMA" id="PLNRYDI"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="250" mass="28881" checksum="491B799AC8A714B9" modified="2014-09-03" version="1">MKRNKRAFNATIIDNDELDFTSAKHGDVSDLDHTEYVAPLEESDADDGPVVVNAAEFVADIPGSAEERRRSPTPPRRTVLNDDDDVIYRDKSGRRITREQWLLLHEKRKPKSARAESTQELSWGKGLVQKVNHEAQEAEERRLAQQPLNRYDIDEEYDRELKARGRWSDPMFCSESRRPGITSPKCVYFASDGDTPKCRFAAVPNRFNIEPGYRWDGVIRGKGYEERWFKAEASRKAKQKEMYLNNIADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Q0</accession>
    <name>A0A061D6Q0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pre-mRNA-processing ATP-dependent RNA helicase prp5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767878.1">
        <property type="nucleotide sequence ID" value="XM_012912424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Q0"/>
    <dbReference type="STRING" id="5866.A0A061D6Q0"/>
    <dbReference type="GeneID" id="24564233"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208460"/>
    <dbReference type="OMA" id="YDDRDQY"/>
    <dbReference type="OrthoDB" id="361918at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="352" mass="40420" checksum="AF6E967413EE9869" modified="2014-09-03" version="1">MKTQGWKQNRVARELGGFEGDEMGRDVALPHSNKFRDNEGKRRSHADYKQGGYYSGSSRRRYDDGASDSYRRHYDAGDHGRHHRYDDRDQYADPRAYRSARYDRRSYDDERDHYVDSRYYRGGRYDDHPKYRKTTGHYDEREQHDDRYDRYDRYDRYHRSGRSYSPQTPYSDRRSPNMRKGEYSPPPTPPADAFMPPEIPPAGDTTAAKPDQRSNLASAHSGASSTHATAHGDQATAKSRDDGKKSDPAHKSDSKVSDPRVGSKLYAARLTTSFDVVTLPRVAPADASLASPPFDMRVQWRSLKPVANGFSSPIERINTYMCAPRTQVFKEWWLKGRFSHAPSNTAQAPCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D708</accession>
    <name>A0A061D708_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0304000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768682.1">
        <property type="nucleotide sequence ID" value="XM_012913228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D708"/>
    <dbReference type="STRING" id="5866.A0A061D708"/>
    <dbReference type="GeneID" id="24565037"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304000"/>
    <dbReference type="OMA" id="ACHVQEK"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000001">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050262">
        <property type="entry name" value="Ribose-5P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748:SF3">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="233" mass="25082" checksum="DC382A3385FC3FAB" modified="2014-09-03" version="1">MDQQECMRRAAEQAVDSYVRDGMVVGLGTGRTASYAVRHLAKLLAAGTLRDVVGVATSVATQRLMHEVGIPSRDLDADTHIDVAIDGADAFDGDFNLIKGGGGALFREKLVELAAEKLVIVVDASKRAMGHLLEAFRVPVEVVKFGHSATMQRVVKRLQPLIRSWSQRRNADGSLYETDNSNVIMDIEFSATDLGRLEAELRSVHGVVCTGLFLGMASAVVVAHPNGVVEVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7A7</accession>
    <name>A0A061D7A7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0303270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768609.1">
        <property type="nucleotide sequence ID" value="XM_012913155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7A7"/>
    <dbReference type="GeneID" id="24564964"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303270"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596043" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="818"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="944" mass="106383" checksum="28D4AD9EEDDE1233" modified="2014-09-03" version="1">MANNSNWRSMWTLWAIVFQLVGFINAAPCNFDYPKGLLSKSAVTSCHMDIQNIASTLVVCPQEVNGTEYVWHPQPNADEQGHLKTYVSGDGSFSSVPLSTVVRSESKNKLFWMETTRSQRTLHLNLPREELFVVTENRFMFICAPRDFVLTEKLQRHLEHLYDKGQRQKLPWKTSIPLNPEVDGLDKGLGVLMVYRGRQHQPLQGCGSRPSPLFAEGNEVTVDRITGTTSCVVDPMSQSPIGFVCEGKVEPENCMRTLLGKTGEVFNAPRPRRYWKFENHKPWTLVRYFNDLALPQFDGECRCIDPETGAVKAKIEVRRKTEHVCDIASVINNKWSDHISGPLCTVVLHPGSTLTIKIPTEDMDMETDMDIDSDTPPVELMQKRPKYSFKNEILPSDMNMLRQLNTPYGVYVYDEVLYHKALVGDALELDTSLIDKGEIKLKYHLGKSLALRSGQNSFFYEHTFKTGNKYVPSRIRSVVNVSFAFTHDYETVGCDRGSDSAFNTDVSSNYCLTRTMGNGIGDTYECIYHNKMNEKRAGINCGPDEELLPANCESLGYDLSSNKVTAFPASIRNVTPYPVRGFQVFETALGDIPVSHACICVDKRGYEKSRLVIENDHREQHNYGINRETAIHTMLPHSWMPLSEFKLNIEEPSLAFYKMHHLYSQSITLKVGMEFTLRCALQPDILYDADTTVMQPVWLPYSREQDHYISEPTVDGTRLIRVAHNETIATSQDGLYIGYNDVVHTVGYKTLVLISRQGAIIVSKDANNREYVPMTFVCGKAPILSDFSTNSRSYALAKSFARFTWNLVQVNVETTDPYMQGCGVTYESDELFKPETPKVYDEEGREIGCKVDLQAAGGAAFYCPAPYVMDPPGCFNQVSVNGEVKDLSDISATLLASRSSHFVTLNSFSALMEPGETLRHTPLLECRCVTTKGVVLSTIQIENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7D6</accession>
    <name>A0A061D7D6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0303620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768644.1">
        <property type="nucleotide sequence ID" value="XM_012913190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7D6"/>
    <dbReference type="GeneID" id="24564999"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303620"/>
    <dbReference type="OMA" id="NMCLSID"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="26906" checksum="AA4613291112034B" modified="2014-09-03" version="1">MAKGAVHITGSNFACRRRLRWDILDRMRKLVQNGTCERPRWLEWVERAPPLETRNMLHCDKTIRNPYPSLVADLLRKYPHLRFEGCYRPDNQWQKGLDNYAVDHPVTQFVANQLALMNRGMSRREAFLKTEQMFYKRRMETEGRLKVAMALGVDESAEPLYTTGYAYLHKKIAQERGVFLTHVRDELRYLKIAIEPICSFRRMKNVAMQRQQHKAQGVAPADDKSDNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7E1</accession>
    <name>A0A061D7E1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0210500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768083.1">
        <property type="nucleotide sequence ID" value="XM_012912629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7E1"/>
    <dbReference type="STRING" id="5866.A0A061D7E1"/>
    <dbReference type="GeneID" id="24564438"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210500"/>
    <dbReference type="OMA" id="NYIWLLQ"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="78"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="320" mass="35332" checksum="A97591DA57940C46" modified="2014-09-03" version="1">MYTRLITGVFGLCFIRHTPLLHISQLILFSRAFTTSCGTRHATLVGKVNRRAFSSGNMFNDILKKPCAEVVPVPVFSDNYAYLLVEHGTTNAFCVDPAEPRTVLQAAGERQLTLTAALCTHKHYDHSGGNTEIQRLVPGITVYGSSYEAVPGVTHGLMDGEVIRLGSLEVKGVRAACHTVGHMMYYVSNPSDPSTQPIMFTGDTVFIAGCGRFFEGSAANMLDIMNKLRAYPKETLIYCGHEYTVKNLQFAKTVDPSAAVLRKLEWAERVRAQGMPTVPSTLGEELEYNPFMRSSELMGTVGESTEEGAMRKLRSMKDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7F3</accession>
    <name>A0A061D7F3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766990.1">
        <property type="nucleotide sequence ID" value="XM_012911536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7F3"/>
    <dbReference type="GeneID" id="24563345"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111020"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="9823" checksum="1DA9735CECDD6585" modified="2014-09-03" version="1">MPLSTYLLIRKQISMVMKYATKLRPVPMSTPSANHVHAASSQPTDMPVQVREDEPAGNDLISMRSGTGKPTIISSDTQHKTARMNSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7F5</accession>
    <name>A0A061D7F5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768098.1">
        <property type="nucleotide sequence ID" value="XM_012912644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7F5"/>
    <dbReference type="GeneID" id="24564453"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210640"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="157" mass="16351" checksum="72143F4C0FFE5DCF" modified="2014-09-03" version="1">MRRAQHQLLGVAGGNDACADEVAGAEPFVHRGVDGLRLVDVAAHDDALQPLGHRLVTDADDAALDLIRRQLGHLRDNDSADGRGGGGAGTECDRGHLKPMRQHSGAATYPVLGILINGGGAEHSGVDERVPDVDVVVGTLGRGGAQTEPRQHNSICH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K8</accession>
    <name>A0A061D7K8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0211190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768158.1">
        <property type="nucleotide sequence ID" value="XM_012912704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7K8"/>
    <dbReference type="STRING" id="5866.A0A061D7K8"/>
    <dbReference type="GeneID" id="24564513"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211190"/>
    <dbReference type="OMA" id="YGFKFKQ"/>
    <dbReference type="OrthoDB" id="360088at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596054" evidence="3">
        <location>
            <begin position="24"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="213"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="594" mass="67387" checksum="FC9DD50E2DDCC3E4" modified="2014-09-03" version="1">MWQYWCQAALAVLCLVWLHQSLGCGALSRRCAPVDGFAFPGGVFCSTPRGYLAPPSHSSVRWKHGYAFTRASGISGRDADSLYRRITANLSRAASADDSSVEAMGIPDSPLKPKPLPIDPGVPLENQPLPPWALEFVTGNEVPKGPYTPRHYTEAEIAAHFEKVNADTRSRAVTRHVQESKGAPLKSYGFKFKQIQPVRHHNGRAFTFFYAHSLHTDVIPVLMNSLRRVAKRHLGAGRITALRIPGMKNEFYSVVGLREDFFDLARNLSNVIFRNVPLTATFEKPLIGRLRLKGPIIAVAGHLEFDEDAQTEGRGTSSGSAEDRKIEVVNKNHYICALSKDAYLDMEVKIEYIANYVIPERGPESLNRDIGPDGFIHFCSSCLPVEVFAFDGDRRGMDEDSTSEIVTLELHTDGSTTPRLALLNSATFLERWFERTLEAFHNDCKRDLDALEESKQSMHIDELMHHELCRNVPWNPYRLPEDRRSAKARWFYRKDVRRQYPIDPESKLAKEEQRKEWEEVLENQMKYNERIAPKLVDDSESKPDRYLTHEEIEELAEMKAPSWVFQDPLGCGYLGQGAVLEFDKNGNPLEFPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7P7</accession>
    <name>A0A061D7P7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="6">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0304710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768754.1">
        <property type="nucleotide sequence ID" value="XM_012913300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7P7"/>
    <dbReference type="STRING" id="5866.A0A061D7P7"/>
    <dbReference type="GeneID" id="24565109"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304710"/>
    <dbReference type="OMA" id="ESRHLEM"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="360" mass="41180" checksum="CBCE4AFF8E76BF37" modified="2014-09-03" version="1">MADERSIDAFDTSRHAVGCKWSAVQAGYVEDSYIGYFTDGKKHGPIHNMLHFLRINAIRQAISAFIEQFPDENVQLVNLGCGFDTLAFWVLQHYPKATCFDVDKPRQLKAKAALIRKAYPVMELLQEFDGDGDKIIDAKRYKMVPADLNNITEIEMLVSNYNFARDQPTVFLSECSLVYLDVEKSNKIIKFASSVSSGPSCFVYWEPEFGSELHGSIAYPTIESQIKRSWNETDCEKKANYIHDDAETLMHRYTELGWEKVAIMDMNTLYNVLITDEEKRRLRKLECLDEVEEIVIVCQHYVVGVCGTKPERMSKLFDTFTQTDAAKTIRTYTTEEVREMIRSGTLSEMQPASLSTGWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S7</accession>
    <name>A0A061D7S7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abhydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768233.1">
        <property type="nucleotide sequence ID" value="XM_012912779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7S7"/>
    <dbReference type="STRING" id="5866.A0A061D7S7"/>
    <dbReference type="GeneID" id="24564588"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211890"/>
    <dbReference type="OMA" id="GENIYML"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="58"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="285" mass="32011" checksum="C1E6EBBD2B3DEBC9" modified="2014-09-03" version="1">MGNSLNSVVFHPPKPTYSGGDPHLHMLPTKCGHLIAAFYIRHRYVVACNSCMLFRRSRFTILYSHGNAEDIGHVFHALMDRVANWDADLFIYDYSGYGVSEGKPSERNLYMDVEAAYDYLTQALGVDPNTVVAYGRSIGSGPAVHIALHRPVLGLILQSPVASVYRVRFHRLPFSMPGDIFRNIDKVQNLNVPTLILHGTEDETVPLVASQQMALKISEVYCRWIKGASHNDMDGKYVIYVEQALQEFFARIMQQHPANVMRKGVWISRGKQGTIHHNAAQAITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7X8</accession>
    <name>A0A061D7X8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0306900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768972.1">
        <property type="nucleotide sequence ID" value="XM_012913518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7X8"/>
    <dbReference type="GeneID" id="24565327"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306900"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600675" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="826"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="955" mass="107757" checksum="B070B17D1EE55439" modified="2014-09-03" version="1">MANFRNMTPLQIFCAICLYCLRGIDASVCDFGGPDQLLGQNDLAICDKYADFLKFETVICPRHVDGTEYAWHPQSTSADYFRINTYVGVNGKLRSVAHSHVVRSESGKRFFWVESDPLQMKLHFYIPYHEFVAINERRLIFICGPRNLVLTDALQQHIYQLSALQPEARPRSSTIPLTEEIAKTGQSLGVVFLYRKNMHQPLQGCGSRPSPLFAPDNEVDVDPETGTRSCVADPMSESPIGFLCEGRIEPENCMKSLINPRGKVATAPRPRPYWDVKGYGPWVVGKYFNDLALPPIDGECKCKDPKTGQVNAKIKIRSKTDYICDIASKILRNRSQPISGPWCSVVLHPGSTLTIKFPINNSNLEAPKEGDPTVTFSQMMSLHEYQTEFQPYNLNTLRQVTSGHDVDTYNEIPYHDALVGDALELDLSQMHRGEVMLKYHVGKALTLKSGLNSFYYQCTFTSNKHVIDSIRPVVNVSFAYTHHYQMRGCDRGAQAVFDPNSNRSYCSTISMGNNIRNTYECVYNMRQVRQAGIHCGINEVLLPGNCGSTIYDVFSDEVIPLPQSIKTATRLSIPGFQLFNIEIGKAGAFSLACFCLDQRGHETSRVVFKKTESLRYTFKTRRVDTALNRTRIRYMLLKTTDLLLEESTPTKLIMAHKALKKSITLAVGKRLILECKFGFHDIEAYHGAMQIEEGWPLTKWWPNQPDIFYYAVTHTKHGDQLIRKKYENEIITTPGDFKLIYRDLLRTERYQSLIIEAHKDSLIISKDPMHKYIVPLTFVCGKELEPADAAIIDGEVPASTTTHVLRSSKVFTWHLVEVNLEATDPYMQGCGVTYASAGLFKPETPKLYNAEGQEIGCKIDINTAGEAAFYCPAPYVLDPPGCFDQVSVNGRVHDLRVISRSLLTMCSDHFVTVKFDGARIGPGDIMWQKPLLECRCVTTKGIVLSTIQLEHYYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D831</accession>
    <name>A0A061D831_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulphur cluster biosynthesis domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0307200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769002.1">
        <property type="nucleotide sequence ID" value="XM_012913548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D831"/>
    <dbReference type="STRING" id="5866.A0A061D831"/>
    <dbReference type="GeneID" id="24565357"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307200"/>
    <dbReference type="OrthoDB" id="365915at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="408"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="516" mass="57354" checksum="F1E411316265DF64" modified="2014-09-03" version="1">MGKVKSFFRVLACPKKGGTRSTRTRAQDKPSNEAAEDTSGHIFKKNISVDEEENFSELRGDNFSFSAIVNSTDAVVQQPECAFANFNQQMSIECPEGSRQHVAIFSLCNILLFKIKQDLLLALFCLHRQSMRVHLRRQFVKKIAYVFKRNLENSARHAVITLRRYRMPLQHHPKFLIAITRIENNLEKPVVRNVQASFQALRNRRPPVTPPGSTSQRSHAASEGKRQGSIISSKPDSAYICNKSLGVSSTQLTQGYQPRSNTTGTSRPIKLNDLARHRASTLSGNGAVDANGAHLRAAQSCHSKSASTGPSVTRDDKGAALKCVDECIQQDIHNKTDCSSSKQVDKKKIGNSIFQNAIKGAQRSIPAVAEQKTNIIWELDFFTCEPYVSYAYKSIRCSSLTRNDAPVSVTVTPNALQRLKFLTRGNENRSLVVSVTGGGCSGFQYNFKIVDDTNDLRCIYDSDNCMKVFSDDASLELIDSCTIDYQNNLVGSKFVLDNIRNLSKRCSCGNSFDIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D858</accession>
    <name>A0A061D858_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769042.1">
        <property type="nucleotide sequence ID" value="XM_012913588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D858"/>
    <dbReference type="GeneID" id="24565397"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307600"/>
    <dbReference type="OrthoDB" id="10371097at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="825" mass="91369" checksum="AD7BA0DB96BB49FC" modified="2014-09-03" version="1">MKGRKPDSKINGRGIRRGCEAAMVKLENLYFHEFDNEAAPLGVRRIQRVADSRPSMRPNIFIQPELISRLDPFRRVYYDECRPLFPCPSESPGAFLSEETLRRQAEAAASIWKIEPFPRSGPDQAASLNNCGYLSYKGAIQHTSFILPTQRTPVRTGTEQSGGAGSTLSGKKGSPSNSLKALSHRLKDILKSAMTDSDLRYIKGDELVLGGCAVDEVEICTPKHQDRNNQHTVTKDSVDSAPDPITHEIGFKEPPHTNAGTDGSGEDGFIDAVSLSSSSEDANDGDDTTRHADSRAAESRDAGAVASGNTDRPRAADSGGALALSAPRTQIDGAGSDQRRGVEAPSPTVTPSAAVHCYPPTALMRFHLLQGSKKRLAQGTADINSPSLSSHQSKDPIAPQIARDRCLDTKPPAKSASQTEVGPRPVGPVPGRETMSDPSESRNPDAPAPRSVAKRGSTVIDAGGDVLALKSAHLISNVVEVNPSGRGGILQHLKQLNNPVESARVAALEATISSDDEGRPTGKLVDKKHSIELRRNSLYREFIDNYNEKRKTKFLKGIRIPLKKNDTQTTLQFGDLPNASSRSAGCGNTPPHSAPSDRAPALSTDDESPPHNSRYYGRRASTGGYAREHGGREYQEEYPPDDGYKRRSSIERYEEPRDYAPMRSNRWSSDTMYDSHVHPSDGDWYHYRPLSRQGSMSSMTASDGNTAESLHSSHVYRDRSFDCYDEYESRSGCSRRTQRLGDYVRDSERSRHRGSELSVLQSSYPPEYRESYSKYRESERYAPEHDRRDYHSSDYRSRDRDYAYRPRHRAYDMDAPRHYGRRWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D892</accession>
    <name>A0A061D892_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0301070</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768388.1">
        <property type="nucleotide sequence ID" value="XM_012912934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D892"/>
    <dbReference type="STRING" id="5866.A0A061D892"/>
    <dbReference type="GeneID" id="24564743"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301070"/>
    <dbReference type="OMA" id="YCAMKLP"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595549" description="protein-serine/threonine phosphatase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="47"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR96202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="586" mass="64054" checksum="AB30B945F6371FF5" modified="2014-09-03" version="1">MLLYRFRPALSFLSLYSHLLSMGAHLSSPKTDKVSCSGGDFSSHTTRYGSSSMQGWRVSMEDSHLAVPDLYQRCSSNGEKETDNGRETQVGNTAVASNKLDALGNINNSLVGVYGVFDGHGGSCVSQWVSENFASLLKGEIARLSELKNNQSIELKSLDAISETQAVLAESLQSAFLKVDEELQRAETEQALQKLNERPRSDNVNESFVDGSSLFKVLMPDRAPNRQQTIRLIEQHTERLLRESFNFHNSNQSDVHSTEDLTRYSEDDEDYQQKSPDDLDEDVNDEVYRHTSSEAHSVDISKEGASIRLNDLGPKTQDSKTIQDQMVTRTVNDDESMRSGDCLPDDEYEVETDAIGDGDGPSLAYGCGSTSVVVVVVGGETPAILVANAGDSRAVLSRGGQAVALSHDHKPQLREEGERIRRAGGSVTNGRVDGNLNLSRSLGDLAFKRDQSLPPAEQRISAMPDVRICPLTPQDEFIVLACDGIWDCKSNQQVVDFVRSRLFRDEGAINDAVDSDGVANNDPGTLAKICEELCDECLSSNPSESEGVGCDNMTVVIVQLSKHLVEKATTSAQPITLYGKQVDAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G5</accession>
    <name>A0A061D8G5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767395.1">
        <property type="nucleotide sequence ID" value="XM_012911941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8G5"/>
    <dbReference type="STRING" id="5866.A0A061D8G5"/>
    <dbReference type="GeneID" id="24563750"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203670"/>
    <dbReference type="OMA" id="CAYGNNC"/>
    <dbReference type="OrthoDB" id="366478at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="500" mass="48203" checksum="7B8F60313923235A" modified="2014-09-03" version="1">MAFFGNQQAAQPPIGSFGGGQPAPTAAAGIFGAGSGVGANVAAGGAPATGMMSSGGFGATSAMLPQAAFGSANSAAAGFGSGANVMNTSFGSTNIGSAFGNTGLSTGGGFTSNGFGQQSNVTGFTSSGFGSSTNNASSPFAANTLGAQSSSGFGSSSSGMPQFNTGPFVSNNFGQPQSSGNTFTSGGFGQTSNSQVGAFGGSASGFGSSQNGGTGAFTTTGFGQATQPSTTTGFGQTAQAPTTTGFGQTAQAPTTTGFGQTAQAPTTTGFGQTAQAPTTTPAFGQLPAASTPAFGSSANAMGTPGGFASGGFGSQSSTGFGTFGQGAQQFNTGAFTSNGFGQNKNANSLSSAGFCQQQSQTGSAFGSSGLSQPQPFNTGSFTSNGFGKNAEAVTTFGQPTTQSNGASPGFGQATAAGSAGLAPAEPTTTNQSAFSGFNKPSLGNPSCTPANITLFGTNTSGGFGNKPVALQIEPLTRPCNAKLEPWMKTAYSARAFQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H0</accession>
    <name>A0A061D8H0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767400.1">
        <property type="nucleotide sequence ID" value="XM_012911946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H0"/>
    <dbReference type="GeneID" id="24563755"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203720"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7205" checksum="91D46FB5C0354B2D" modified="2014-09-03" version="1">MELSDVKVNVPIHEYTFSVIVYDSDEMPMSGVMLSWQLIYESTCTNNTGTYYCRLITSTTNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U5</accession>
    <name>A0A061D8U5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769154.1">
        <property type="nucleotide sequence ID" value="XM_012913700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8U5"/>
    <dbReference type="GeneID" id="24565509"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308710"/>
    <dbReference type="OrthoDB" id="367252at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="84" mass="9043" checksum="DC54C87A33ED4093" modified="2014-09-03" version="1">MRPNRPRNPSGMLMGPNDPFFEEGPRQLRAPGSTAPRYDTIGPFGREPDPSIDPSLHPWSPTANRGGMMGRGPGPFPGPGGPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8V0</accession>
    <name>A0A061D8V0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769159.1">
        <property type="nucleotide sequence ID" value="XM_012913705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8V0"/>
    <dbReference type="STRING" id="5866.A0A061D8V0"/>
    <dbReference type="GeneID" id="24565514"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308760"/>
    <dbReference type="OMA" id="WNYELLL"/>
    <dbReference type="OrthoDB" id="360726at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1076" mass="122048" checksum="513E9B8BE2587BD2" modified="2014-09-03" version="1">MVVERVSTAEYLGKWHVDAVHAHRHPGRVRAAAARRTSEKLYKRLVKYGRGYEVRPEEDIPGSRVLLGELLLVSFVEQCNSGGSAEDMMEQFHNKCLHEISQTGYLLSYAQPYNLPPLMTIQNLRRFGSSHSLSDLSPCSPQATGSPTSRSPSRVASPTAPLNISEVDVDASTRMTIGEFRDNEANVGQSPRSVAENDMSDAAMMAATRPTVQRQVSSIPFGAESAEVFYGPAQYSKSPQRLLETIGHTSAHLRVWDSRELESVVPRNCTVLWKSRIATLFTIAASFCGDGHVYTCTQCKQLLRVISSSFPWSLTLLMRCMKRIDHLETVYSQMFHRLVRLYSKGDALTGTYYAHVATGIAYTVDTPALVETEPKTLVHILAGWLADRRIHRFIEPYPSIKLHKILLAAIMKLGPSSTTMRVDREHLELLRGAVVSFMLGFGMHVLEDICKAGRISFDKYTTQGVRYSYRLNLRLRQLRCMVEEYVRVAAPFAQKASEARMIVAPFLGNPELYRWLLSMNFSTWSSEEQRMQCRLAIVVLYLVAVNHQHPYVRSEDIRFLRKFHCLPWASAISFCCKDPAINHMVAPLTSALVQCLGEGAVLNLVSGDTVVSMLNEVMMKVSTGEKELHGYRELKLESIVPLERTTVYTPLRILWPKIMSKVLGHTVRRMSLPPMLYYSVAHLMRIIWEHHDPQEGANAAIVHVNNEQGRFKKFYNEARKQSLEVHWSICHLNMLYSIESTLFDSAFLDSIIYNYVVERDPASSPRQKNALMLFCNETKGADMQKLFSSNYIALHQNPINVLLRMPKKAVLNSFALRAFPNMLLQLFHSLYKYVCYGLSSFNVHRKTQLELTHINALQEAAALNVILDMLPEKLTRTVEINISSFLWMLSSRATFTDDVIASSGLPPNKILLWLNLGVPEERRFEKVAERFNVAAENLLKSTAVNPNGTGENITIIPSKDGRTTCLEPYSAGDVATYHLYTVLLQVMEMPELSKTPANIAEDANAQRFAWVIDTYWRCLQKANLRNSVLEFIKSSISIVLRLHYLCPWMVNKSTDQLQTWIHTDRSCEPELQEFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8X5</accession>
    <name>A0A061D8X5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alba-like protein C9orf23 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0303260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768608.1">
        <property type="nucleotide sequence ID" value="XM_012913154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8X5"/>
    <dbReference type="STRING" id="5866.A0A061D8X5"/>
    <dbReference type="GeneID" id="24564963"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303260"/>
    <dbReference type="OMA" id="VCFLTIT"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="6">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="169" mass="18241" checksum="AF686858B194D3F2" modified="2014-09-03" version="1">MAQVEAVAQAEPKQLAPGEIRVSSIGVVSSYVAYAKKLIAAGEPVIHIRGTGRAMSNVVETAEILKRVYKGMHQVATLDTQENLVAAVGEDGKEQRRSVCFLTITLTMDPSKIDTTAVGYQKPLTDEQLGEVEVDKLIQALKTSGIRKKGTLPRKPRGTVQNAENGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Y8</accession>
    <name>A0A061D8Y8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769199.1">
        <property type="nucleotide sequence ID" value="XM_012913745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Y8"/>
    <dbReference type="GeneID" id="24565554"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309160"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="129" mass="14778" checksum="F9A3687D2353A28B" modified="2014-09-03" version="1">MGATCWHPPCSTTTATHNVAIISESHILYHTTTISNPVSYVNALSPSFNSSLDILILQVSISTRFFSLGRVPLRDRQGRYAVHHPYRELLLQVVTITDVLNGMRAREKQQLIYNWALRVRTIIEIWKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D977</accession>
    <name>A0A061D977_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767650.1">
        <property type="nucleotide sequence ID" value="XM_012912196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D977"/>
    <dbReference type="GeneID" id="24564005"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206220"/>
    <dbReference type="OrthoDB" id="367035at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595932" evidence="2">
        <location>
            <begin position="24"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="945" mass="101392" checksum="9530EEDDD1D0799B" modified="2014-09-03" version="1">MQWFIPVTLLCLGAIDFFAKSAAKPTASLPKVRYVSFPVPRLANAANSRRNNGRYHGGNGVGASNARPSSYPRGTPTVGRSRVPSLVDDGQPPLNPGSHVYNTVDDPKWRQIPPPAGWNPERKRSGERLSGSPRSPHNDDRNVDASNSKPSLSSLKGRSEDKNTPVAKPGGDREPTKPKPSNNGYNVSPSIVKPALSSKERTNPASSTIKQSVDDSKPSKNIPSGHGRNGQADVKQTSLNPNGKTEHPPSSFTRRDDVKNPAKTNDGNQALASDAKSSSSSPKVESDDKNTPVPKPDGDANAQAPTSGSQGSNKIPASVLKPLVSPGGKPQSERSKLTPPVDDTAATTNKPNKRRVRFDESIFRPSPSSPKVGSEDKNTPVAKPGGDANAQTPRPGSQGSRKIPASILKPSPSRDERGRVRTPPVKPLVDGTATPKEELSNSDETKLGSSNLKTAPSSPKGKVRFATDPIETSEDDEKPSTEKSVDDEDAEAKVETTSPSPKEARKFASSSIRKPVDGRPPTRKTSIPGKQVPGSGTNMSAGYPREMFDFEFIPMGNLHDKGDKYSQPHDERRFQIFDVRKLIEDDNKLPHKTMKVGENTPTTFNLPPPSLNGNKDRGILPVIPLTDANIPPTPGQDKPSTHYILVPKVEDNAQQATGMVHNNHAPKLSDAATQTSPSLPKENGKIIPIDIKSFIEDTKAATAMMARYSAPKMAEIATQTNISHLEEEEKVNPSLVVPSVDDKKPTTLNTDGKDKADTSDTKPSPSSARNGGEMKRFSAQPLADGLDSDLRSPSFEGNEENVDSFHLRKDANDNKPAKENSNDGGDSIVVSDSQQSPSSKDVPKSESSTIQKTVDEKKPTKDVPIRDGKDTKTNEKPSSPPSEVRGKTESSNSSQIATDGNASLSTPQQLRHFALNRPRRNDDTKAAPPAAKSCGSCCKKKRAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D978</accession>
    <name>A0A061D978_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0304400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768723.1">
        <property type="nucleotide sequence ID" value="XM_012913269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D978"/>
    <dbReference type="STRING" id="5866.A0A061D978"/>
    <dbReference type="GeneID" id="24565078"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304400"/>
    <dbReference type="OMA" id="TSECANA"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="5">
        <location>
            <begin position="69"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="517"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="711" mass="79229" checksum="AF75C4364BBD3583" modified="2014-09-03" version="1">MLGGTDSATGSSAQTQSRQIMDNQNLYSVAVKRPRESPSDLPERVDEAPPTDNSKAKATQRTPEEFFHAYVTELERMISWAISSLNRSRAELLDVCFVAYLEIYVKLFRTSAEHGRRFLKQFAFVFEAKFGHFVKQLLEFLFPDQLANSPLIRQRVFLQKKYYVILSKRAMRVMLGWLNNNEGSLVDDVIKEGVEFLDGETFNHSQGHLFRRHFIAKHGIDPTTAHKFKRPFHGLYIRDFDNELRVHQSKSTELLAKAEAPYVPLGLPGELVAEELQQEYGRQMMETITGEHAIIEDPDKLVPLPKQGTDYHQSLRGLLYCQRECRVPEGKSMLLSYTLQNVLRSTSCAISAFDGRFAALGLDDGGILLWDLVTSECANAVKDVAPVLGESIATRCVTKCAGNTTVARMMHSKSAPANGDQQKEGAGSGEGILHGHDGSVQSLKFGECGQVMLSGGVDGEVRLWVMGSRSTRCVYRGGDSPVMELDYSPYGFYFASCEADGAARLWATDRSFPLRLLRTAQADCLGLKFHPNSSLLATPCSDGNIRFWDLRTSGCEIVMEAAPCGFRYSHAHSNIIAIAKNGRLFAAANGTHVSVFDLYQRKRMQVLLGHSDPVIAMDFNHGTSELAVSDGGVVSLWNVNGTRDWPTETTEPDKQDLFTKRIERFAQFNDDGAIKLTNAFRTTDSQIREVAYTPENVLLTLGLSTLRDVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9J0</accession>
    <name>A0A061D9J0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766571.1">
        <property type="nucleotide sequence ID" value="XM_012911117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9J0"/>
    <dbReference type="GeneID" id="24562926"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106940"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="306" mass="33652" checksum="4F703C8BCC1D4BB3" modified="2014-09-03" version="1">MNPLGPLVMRPMGLNPRAMMKHSALVSLEAAGLWMLKSSKNMFTCLYMGASESLEKALHTNRPSGSSTDAHTLMAARIRHDWTYASVSWSPLTSGAPSHDTIWARLLSAREAFANILNEQILDVLHNLLVRDVSLYDLDSLHRRHVLQVHRYDHGLHRAAVLEPGANRLLLGDRLRGVLVDEVLVVHEVAYALRPAPGRRAEIHHVPDARKAGAVVYLSPGFANVEFVDAAQVLVWAAVLALGITEQLHDRVYSSNRMENSVRLENVEQFVGASSAVTILLGFAIVNVPILLGGVSHLRNRIVCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9P0</accession>
    <name>A0A061D9P0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0313040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769587.1">
        <property type="nucleotide sequence ID" value="XM_012914133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9P0"/>
    <dbReference type="STRING" id="5866.A0A061D9P0"/>
    <dbReference type="GeneID" id="24565942"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313040"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="194" mass="22048" checksum="474A797B4481AA3E" modified="2014-09-03" version="1">MSSSVDDKIVGKHEVTPLDKEIAKCLVYIESSGTGEIKGDIKNICFSHCKEVEVGALKKSAVIVFVPYRVYVNHVRRVHGRLLIELEKKTKKHVVLIAQRNILPKNFTGKQFRMRPRNRSLTSVHEAILEDIAAPTEIVGKVMRVKRDGSRILRVYLDPKDKQNDNIEDKLETFAAVYKKLTNKDAVFSFKDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9P1</accession>
    <name>A0A061D9P1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Monocarboxylate transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0207930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767825.1">
        <property type="nucleotide sequence ID" value="XM_012912371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9P1"/>
    <dbReference type="STRING" id="5866.A0A061D9P1"/>
    <dbReference type="GeneID" id="24564180"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207930"/>
    <dbReference type="OMA" id="PEHESTL"/>
    <dbReference type="OrthoDB" id="365239at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="839"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="934"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="977"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1001" mass="114025" checksum="0A2846A0D1D924DD" modified="2014-09-03" version="1">MAEAVVPSTSEECTVKKDGVKDNCSKCKCDYSCIGNIFFRKRKKRKEEIKKQAYPYGLSKYVVMCLGCLSICLTSSLYYNWTIFEDLFMRQGALAGLCTEEERKAAKPNTFICDAQRRQISNLYSAIMYTDSFVGSIGGYIGDRFGAYCALLIGQVFGIIAFVMFYLFTQSTIMLYVTFMFWGVSASFALAPTWHYSRMFTFGNNMAVSVITSADNMSMYTPTFFQMIANRYNIGFTGASLTYVFWGILVCIAVTLFFIPKRFIVMDEEEEESDENYELSAMFNEGMMKAVKSARYWLSVTCYVLLCSVRLFYRRSFTLLFFDNEEVTEFLEVSSDFSFAGSFVLGYMNEFFGVVPMMGVTTLMYIAALIAVYFRNFPCAYTSALLFAIAQAGDIQQLITFIDEYFPEHESTLMGLANIVNTIFGLLLQYTFNHVFDWLGPRITVFVMILILGGVLVICYIIELGMSHDNDEEEEEEDKKEENQKESIAEKEEMDYNPLGPKILLYNIFGAFLSFPYFASLCTAVAINNMNQEDKIEESELEDRVVRKLEKDQFYVSMDRVVELCSAVFYTSLIVLLGCIFEFSRRTELMQTHNCILLLMSILIGCAGGTSLLLPYTQIFSVMPPIVTVALTVVPPLSLVVFGWVDRRDAFSFTIMCTLVGVYGFVLFMAGNIMLYMNALMGARFGKPAHSLMGWSNLGMGYFYTLLIIYTIRELYTGDCNIGGYIIVMGMQCAISVFATLVLYLHLSHEQQYFYVKCKNDAENSEKCPTEESGNCKHDDGSATHVDYFVKNNDGGCNHRLLKFRSQYSQEFEKIRNPDYGLLKMEYSTKGILKPDHHLLFLAISVLISLSDASMAFLAPGLFVHMTLMTVSAYFTVRLLFAFLDDEIEKAVKDAATYLGYIWGALLSICIALFVLNAYQLKWLTVEEIPKSTYIIFCVSYCARMWLNAIVQHHIISRLEQFKMVKWESKSEHAHNTVMYMNLGHCGGLGVLTYLCYRYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q7</accession>
    <name>A0A061D9Q7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766651.1">
        <property type="nucleotide sequence ID" value="XM_012911197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q7"/>
    <dbReference type="GeneID" id="24563006"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107630"/>
    <dbReference type="OrthoDB" id="10420012at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="335" mass="37709" checksum="5770299E32FFC8D4" modified="2014-09-03" version="1">MVAISFLFNGNAAPLNVNRPDKALNEDIMIYINGQRMTYEALKKADPRQDIIYLISHEHMKKHINYLKDLISHYDGVHAFIPYLKNIIKYCQRKLDGAKEKPYVTFNRAEFRTEYPAIFRGIDRTPLQPISPAYYRQVLLALHRFSDAPLQTQGFLMHTWMFLCQRVYEASITEMRTLGVANTAIRSPEKRNDTTPANTVVNGDTSSRNGTTVSGDNTPNAYELLYSTSAGNTSTSPYVIGSLGAWEPAPDPPLDNSNGSVETAGRSNDNAHGHQNASENEWDAECDDDDSFSNLCTQPEEPEEDDADWDAYFKSFLQRLKKIPRGNLRSGAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Y8</accession>
    <name>A0A061D9Y8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0312210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769504.1">
        <property type="nucleotide sequence ID" value="XM_012914050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Y8"/>
    <dbReference type="STRING" id="5866.A0A061D9Y8"/>
    <dbReference type="GeneID" id="24565859"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312210"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600185" description="tryptophan--tRNA ligase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="399" mass="43725" checksum="6F8957F7A7A6146B" modified="2014-09-03" version="1">MSVRVSSGFTASRLFWLLHSTVWLWLSLGARGCSCVSTGRVNGRYAGFLAPQPRPGAVRSTPLMGAIAGIQPTGDLHIGNYIGCIHPAVQYQNDGGQLVFMVADLHATTGDEPVVDLGRQSLSTVATLLACGVDPERTSVILQSQFPEILELNWILGTAVSLGRLRKLANFAKRVVAQESDSVGQCLYPLLMAADVLCSDSDTIIAGDDQACHVGLIREVANKLNRRISQPVVKVPERYHNGGFRVLSLDGAEKMSKSNSKEASRIHLTDDDEAIFTKLRAAKTASDHDLAAPEIANLVRLMRFFSGGFVDETDGCGRPELQFSELKSRLHEAVSSHLRPIRTRYLELMQNDAMLKAVLQSGRRRQQPVFSAVVEVRRSGRRIHGAQRVKRASNYCHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA7</accession>
    <name>A0A061DAA7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769669.1">
        <property type="nucleotide sequence ID" value="XM_012914215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA7"/>
    <dbReference type="STRING" id="5866.A0A061DAA7"/>
    <dbReference type="GeneID" id="24566024"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313850"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="279" mass="28464" checksum="198A6BF6AFF81535" modified="2014-09-03" version="1">MALVSTLVTTLVTTLISTLVTTLVTALVSTLVMALVNTLVNTLVSTLVMALVSTLVNTLISTLVNTLVNTLVTTLVNTLVNTLGSTLVMALIPHPVERPDAEVDHGADDDDDEGEGDDGGVISGIWVKNVCANKLRILAVERDAEGYLAYEEIADVAAHREAEDAQVEQDDGDDDSNDDGGDGGVGRGGTSYFTAHIPHPVERPDAEVDHDADDNDDEGDGDDDVRGGGGGGGRGAGGKLRSGGVLMSGGGGTGGRSGGSRGNNSTIGEVYGSLFASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG5</accession>
    <name>A0A061DAG5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769729.1">
        <property type="nucleotide sequence ID" value="XM_012914275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG5"/>
    <dbReference type="GeneID" id="24566084"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400350"/>
    <dbReference type="OMA" id="PICFHIK"/>
    <dbReference type="OrthoDB" id="446277at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="113" mass="13189" checksum="D673C8987FF161F9" modified="2014-09-03" version="1">MAFLFKALMHHKYAAPSTPKLDALRSAISAKLQPIYFHIKNDPNYGTYVYDEHFYGVLCSPLFEGKTYTEINAMVDQILEPLGLKAAVRLNCQPPSRFFKLRRHIRWRWNVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB02</accession>
    <name>A0A061DB02_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767086.1">
        <property type="nucleotide sequence ID" value="XM_012911632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB02"/>
    <dbReference type="GeneID" id="24563441"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200570"/>
    <dbReference type="OMA" id="WRRKYDF"/>
    <dbReference type="OrthoDB" id="365874at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27199" checksum="1F9196FF86A97C23" modified="2014-09-03" version="1">MAKLTRIVKKILLKDAPERDTRRPEAAPPPSVESLATRGLAQPTVDFGNLPIIDDNELRLRAKAKAMVKVSRKGSGIAKERNTASKFKAKVVRPKVKNADASSKPVIPAATEDADSDSAPQSPVKKPTGGTKHAAKTKAKPAAPSTKVIKSDVKSDSRGKRKREARKEMWRRKYDFSNEAKRLVAAFHEEDKHGPALGNLAGLKGELSSLEQMMQSAPPAARESAKPSSKRLLRAKIRNKAMLQAAMKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB70</accession>
    <name>A0A061DB70_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0404190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770117.1">
        <property type="nucleotide sequence ID" value="XM_012914663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB70"/>
    <dbReference type="STRING" id="5866.A0A061DB70"/>
    <dbReference type="GeneID" id="24566472"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404190"/>
    <dbReference type="OMA" id="GFMMHIA"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="397" mass="44338" checksum="4C051283511CF39B" modified="2014-09-03" version="1">MRQPVAATCRADSGYFTAANRYCTAALASWKKRVNASRTIASALLPSHFMMLSRTAHCDEQPSTPEQPPAPSPYDLLVFENLAREFKNVMTQDNYDGFRLEADRQITDNIQASHSLFLGTVMSDVGYLYQIGANYASPDGNLLALAKIGLDGIITARAFAKHGDNIEVKLNGNSFLKYDPRNAYEAGVDYMGRGWTASLKAAWQGTWILNAAYTQQVMPKLTLGSELTYIVSCTHRNLSKPVKVANSSSIGAIAARYVDGDHIVTCELADRPPHQRAGQWTKQPNFKSMDFTMQDTDTARVQYVRRVNERLALATELEVTPATRESALRMGWEYLFRHARVQGNIDSCGRIAMQAQDYSGFGVSGCIDYWNNVYRFGFMMHLLPPQPEPKQDQQVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB77</accession>
    <name>A0A061DB77_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">-Spindle pole body component 110</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770127.1">
        <property type="nucleotide sequence ID" value="XM_012914673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB77"/>
    <dbReference type="GeneID" id="24566482"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404290"/>
    <dbReference type="OMA" id="IEGELWH"/>
    <dbReference type="OrthoDB" id="365821at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="522" mass="58865" checksum="0D8E3DB43305358F" modified="2014-09-03" version="1">METRLQRKLREIIAEITGNRPSDYARSLREEHRDGMLQGNKAYAIDNGGRNITLFIPWRLHGPLESSFRSMAGGPHLLASSFRQMVDDAALFPGSQNARKKEDIINYILERVIGNLGAMDFEQFLHALFLLSKYRASVLRVTEQCAFNHVIALLMRTGDNVPPEGHYVRVDYGQQPEVEGTNRAPISQESTESIDPLVEAMSNVSLERQLSIAPSLVSNEQDVAIGHEASLAISEDQQSDNTICTDNTVPEEPAPVPVPVPTSVPEPVSRAEKPVAEESSVCQPSQNDHLIKITEDKMNETCEIMKTEIMSLRNRMDEYKFQETQKQELLRTISALKDNNSQLQARMEENRATAEETRVGLEAKVNELQNQLPELQSRAEDLEKQLEESKAALDEANQKIDQAKFQHEQHHSIQTMLALQDDYESMLFSAFVSYRDDELCNGEFVMSENSCINFCLDFGLGDAQLTTAASEEPVAKMAYREVCKRAPDGKLTYALFKEFLLRLAEIIDPQSTQKRAFQLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBD9</accession>
    <name>A0A061DBD9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0405010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770202.1">
        <property type="nucleotide sequence ID" value="XM_012914748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBD9"/>
    <dbReference type="STRING" id="5866.A0A061DBD9"/>
    <dbReference type="GeneID" id="24566557"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405010"/>
    <dbReference type="OMA" id="YSGDMRK"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="8">
        <location>
            <begin position="75"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="636" mass="71311" checksum="E22F234A6427EEBB" modified="2014-09-03" version="1">MLTPFLVRSKASDSVSPLSNRSSVLSQRASPCSTPRQLTITGLHDDDRSKYTPCGNVVVELDGKKFYHAVRKGVDLIKVGDSVDVVVRFVNSEKCITRLAKIAAIFQDGRGEMKAEVAYYYDTNDVIPGVHRRFIANKSRLYIHKNSNWRGFTHHNEVVASNEFEFITVDAIDEVITVHENLEAYQAAVDAAGDEAGHYFCQVVCYTESYALKPFDSKSQWRQVMLESSEFHRVYHMGFMESPTGRLQAICADKGKVILGREEEAATIRTFIETGIRQGGTGQLLYVSGVPGTGKTATVNMIVREISDKKLSAKLPWFDLVEINGVHLVDPNDFYRILYGKLMKKSAVNHIAAYKELDEYFMNNQTPCVLIIDEADYIVTRKQKVLFTIFDWPSRRKSKLIVVIISNTMDLPSRMKASCVSRLAFGSLVFQPYRYQQILDVLSSQEDIKSAIDPVALQLCARRVTNYSGDMRKALQICKLALATAKDGKVSTAEMNRVSNTVLSSAAVESLQHQSDAMSCLLVALVLELRETQLSVACARKVYHAFRGMMAVMKPEFGKSISLDTYRQLLVSASLSGIISLEPSAFNELNTKRRLQLYEELGEELGDTAIVPEIDVGHIITALSRNPYWEQKLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBG4</accession>
    <name>A0A061DBG4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0405300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770232.1">
        <property type="nucleotide sequence ID" value="XM_012914778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBG4"/>
    <dbReference type="GeneID" id="24566587"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405300"/>
    <dbReference type="OMA" id="NSARIMC"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR98046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="511" mass="55451" checksum="9B5062CDB08DF240" modified="2014-09-03" version="1">MAESLPATANQPKTKIGTYGPLAEALYYLVSFIEGYDQQVLSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCIIWGLLADKYASKFVLGGGLLVMGAASILLSSASHYKVIVFLRFLHGFGFACVYPVQQKIVSDSTDSKEAEEQAKQSKPSAGSHSGSRTLGSSQQELGTESEKSDKKKESKEASKKFTALQALNCVGRLISAVITTLIARKVLLGYYGWRTSYVVLGYVWILFGIAILFGLVLDTSCNKNKDNTQNDSFMERIPKAFQEVFTNPTAAISIFTIFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSGAGGEIINAITKVNANYAELGSGLAVMVVRLVVCLLFFLGKAPRGKLLWYHYVELATLGGTLVTVGGVDRAIMKDVIDNDNQATAAAIIRTISGISSSIILYQISAYLTEKVFGYVPSRESFETMATDIKERNAEALRKSMMYIILAGTVLNVVCYIAMCFTYPLHRQKKQTSDQAQARIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBU0</accession>
    <name>A0A061DBU0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769623.1">
        <property type="nucleotide sequence ID" value="XM_012914169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBU0"/>
    <dbReference type="GeneID" id="24565978"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313390"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="311" mass="34437" checksum="90692736FDFFCEE6" modified="2014-09-03" version="1">MVYNSLTDIPRNLKEGIDWLIALKGTDGEKNLAAMGAAVYNFLAPCLPERVAEEVVGDAAKGVLNNPVGNPADSKPFLALEHIKLISMGYMWQKELRELWPANVMLKLFIKFIDKKPSELANTIKDNPETVTEKLGKIVNGCEKFVSDIKHPEQYKSAYGKNATWVKSCSQNPEDCAAVFVGIAPMLYVGLESLRDASQDAKKAEPSEAGENFRKVLKAVGLKDRGSSNDSSDLDEAQNRLGEVLQAMGYEQRRIRDSMRGSYVLQSLSVLDHDLLNSLYDISGFDVTIEWGLRKSKSKSTTNVSAYWPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCD3</accession>
    <name>A0A061DCD3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767671.1">
        <property type="nucleotide sequence ID" value="XM_012912217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCD3"/>
    <dbReference type="GeneID" id="24564026"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206430"/>
    <dbReference type="OMA" id="NDRERWV"/>
    <dbReference type="OrthoDB" id="10637338at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="376" mass="44254" checksum="BF7567E2794EE886" modified="2014-09-03" version="1">MTMAARRQRSRSRNRLRVEGRSCSSRWRAYQSRSRRSMRSRSISNDRERWVERSSPRNSDVSRDHSRETRRVVGRSPSGSPDKSVRTGKRGTRRSRDRSDSRLRDFRRRQRHRRSSSASRSVRPRHLRNAETRRRKRSVTRSPSLYRRGSTSSDDNRSKSVYRDGRADRIRDRRRIRSRNRGRSRSDPCTPDARRHRVSRRAYNRRDIRRRVSRSSSIQSKKSDEESVMAFERVVFREGARIDEKHEPAAKDVEGYDTMAGEKEANNIRVEAGARADRHPHCGILAGFPPPRPYRQREDFFDAKHEGTAPVLPELPESVLYGDRVSRYHSQDPHEQTQQADDEARDMWLKYMIDMVETNATIIKNRLEVGINSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCI3</accession>
    <name>A0A061DCI3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767771.1">
        <property type="nucleotide sequence ID" value="XM_012912317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCI3"/>
    <dbReference type="GeneID" id="24564126"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207400"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="8299" checksum="3DF26C21EE78AD3D" modified="2014-09-03" version="1">MLYTALRKISHKPKLDRLQYKIQKISWNHSGTHLAVKDDNALRQFDYPIKALLYIYIYIYIYAILLVGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCK8</accession>
    <name>A0A061DCK8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch repeat and K+ channel tetramerisation domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0207840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767816.1">
        <property type="nucleotide sequence ID" value="XM_012912362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCK8"/>
    <dbReference type="STRING" id="5866.A0A061DCK8"/>
    <dbReference type="GeneID" id="24564171"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207840"/>
    <dbReference type="OMA" id="HTHANSW"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000115">
        <property type="entry name" value="Kelch protein K13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="258"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="634" mass="71198" checksum="E9F5D076B8EF5997" modified="2014-09-03" version="1">MEVDERSSRANYQIRISSYSVKIAGIERCPMTLSAVRAAPEKHTDSPGNHDLPSSAVSVAPSDLDIHSLTTVKGWIGTPSDFMVPKASFDAASNSALASLTAGASARDVGSISLSSDLAPLRLPPERVDTLSSTEDFEHMAQLSLKARREELVRSAEELQAERKAFVERMRQERLVEAEKLSEERRRHGQEIASQLKHVQFEREESRRRIEEERQKLEHEKDIFANYMQLESAKLRQRVELFEQDQRKVLDNKVATQTMVDINVGGVVFETSRHTIAKQPTSFLADLISGRHEVGRDRQGRIFLDRDYELFRLILNFMRNPECLPVPKDLAESTLILNEAAYYKIKFSPYPLALCLGGHDGRAPLGAVEVLDRENMCWRNCSPMQTARMYFGAGTLNNFVYAFGGHNLDYKALCETEMYDRLRDTWHTAASLNKARRNNGGCAFGDRLFCVGGFDGQSVLDSVESYDVRMRNWIHLAPLTTPRSSPMLAPQNGMLYALGGTSGERLQSVERYDPRMNKWEAMPGALLKVRSAGAACAYNNELYLIGGIDNMHTIHNSLETWNSTSQASRYLMEAPVELMDTSLTCCGDSLLLTGGQNTQVSDATYIYKPEVDEWSKGPALLLPRYGHCTVYLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCM9</accession>
    <name>A0A061DCM9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0208190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767851.1">
        <property type="nucleotide sequence ID" value="XM_012912397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCM9"/>
    <dbReference type="STRING" id="5866.A0A061DCM9"/>
    <dbReference type="GeneID" id="24564206"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208190"/>
    <dbReference type="OrthoDB" id="335757at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14191" checksum="7254DD7830BE0655" modified="2014-09-03" version="1">MNAWLPQASYPCGNFSDTSGRNARGLKGSIGHAYTVCIFTGNQNQANFSPFGPREISVLTEFALGHLRYLLTDVPPQPNSPPGYVFRGSDKARKALSLRNKQDNIKGSGISPAAEPPTYATPLKSSHKAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY8</accession>
    <name>A0A061DCY8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Centrin 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0209730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the centrin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768006.1">
        <property type="nucleotide sequence ID" value="XM_012912552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCY8"/>
    <dbReference type="STRING" id="5866.A0A061DCY8"/>
    <dbReference type="GeneID" id="24564361"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209730"/>
    <dbReference type="OMA" id="EFFMIMK"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="20302" checksum="A1C6F453265BF9A6" modified="2014-09-03" version="1">MYPRHDIGHSVPSKIGCGQIFRRGRSEVREDHLREISAAFSLLDSANTGRIDYHELKVAMRALGFDAKKQEVLQLMAKYDNMETGYIDFEAFKEIMVKKISERDPMEEINRAFELFDEDNKGKISFKDLKRVSKELGHNLSDEELRAMIDEFDNDRDGAISKDDFIGIMRQTTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD06</accession>
    <name>A0A061DD06_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0309120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769195.1">
        <property type="nucleotide sequence ID" value="XM_012913741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD06"/>
    <dbReference type="STRING" id="5866.A0A061DD06"/>
    <dbReference type="GeneID" id="24565550"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309120"/>
    <dbReference type="OMA" id="KCENSAD"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="267" mass="29343" checksum="F27BD8DC12087719" modified="2014-09-03" version="1">MAPGNRKKLPQRKAGSAGSIHDVYARALRLSSGAPAQEIPEIPSASETHEDADEVECVQPSPPTDRPASADSKVKLFMWDFNQCDQKRCTGRKLLRMKLIHPLRIGQSFAGVVLSPFGRSKLSLEDLEIVRTRGLAVIDCSWNKVDTVNQGQLSVKHARLLPFLIAANPTHYGRPFELSCVEALAAGLHILGMGNEATRILAPFGWGRNFLEINASNLELYGSQGHTSADMESLEQRFLSSVAAENEERRAARRQLDYQDIGAEAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDC5</accession>
    <name>A0A061DDC5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate-binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768341.1">
        <property type="nucleotide sequence ID" value="XM_012912887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDC5"/>
    <dbReference type="STRING" id="5866.A0A061DDC5"/>
    <dbReference type="GeneID" id="24564696"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300600"/>
    <dbReference type="OMA" id="MATHFNK"/>
    <dbReference type="OrthoDB" id="361834at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate-binding protein N-terminal" evidence="2">
        <location>
            <begin position="350"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="926" mass="104397" checksum="75BC428A33698CAB" modified="2014-09-03" version="1">MADSSPEEGVTVANRQYYASVSSEELATMYDDLIQPTPAPNSVPGGINDAGDDARVIAEETTAARAQNLKSEDECSIIENDKPVENAEKGEHPVVHDIYIMPPETQRYDSIDLSSRGPPTFGDSDRFMGRSYDDEWSYPKAFSNASNNYMVVRNIRQDTRDATLSFGYDEAQHSAAPYPDIIEAVNYYMPSPQKQRHDAPFHGENERRPDYTVSNMGGDTTASTHSRYSNEEEYSGAYEGYSGDESNSPVSTGNGERRTRCRTRNVHRSAVRNASPPSESAQSLDSETNDGASPSLRSTGLFEVPLNVCSMSRIIDPFKGFSKVHTARAVKLLHFTKQGDRTLCSLVKSAAKIIQTQVKDLQVVTIGVCGDSRTGKSYLASMLVNKPTKSFRCSEAYSAKGAMNQMHQPPEGAVWAYVGVYQEKYAYIYLDVDGFENHQAQRIDMIKFLLLLSNCVICNVANPPRTGIYDMVRAMIDVVKHDRMSFEEDVSALEMQETIEEFTKKTSFLLNEQNILSKSFESKEHESIEAAEEVRSDLGEANLWKAPIVHFVFRDSEGHVKCMDDRLYTPETLVEQGIFEHYANIFNCNRRDRGMDFKNDMLDAFEIFTNRKYTSLPCPVVVPKSLSIADRSSALNAKDALKRIFATLLAPANAEIMSADVAVGSQTRLIGGNAPIGQPNISSIPNHLLSPLFCERLDEVKACVYQDTLSHVQSHSHMNGGMFVNYLKQLIAHFNAHGMIKLRDAKTIIRDVRVKENVNISREVIVQFFKGLKHHVVMQLPIEPRVLLSRCMRLKQKSLHDFQTRVLGDQALYREQYEYLEKSLDGLIEKLEVKNDKIANDAAVAMFDKCAKSLDEKLASEQYTYDELLVDIAKMRKMFLEKFKGHSDVTEKVFPQLTRQLYRRYEEHHPKSPTPNMALISKRQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE2</accession>
    <name>A0A061DDE2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769495.1">
        <property type="nucleotide sequence ID" value="XM_012914041.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDE2"/>
    <dbReference type="GeneID" id="24565850"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312120"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1722"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1796" mass="195188" checksum="D7957E165A63FB90" modified="2014-09-03" version="1">MAKHGVKLDTLKDCFQFLQWLNGPKGQTRNVITEFVQRLSPYYQFNTQLKGQLQVQYTKFLKNVSLLYKALSSNEHITRRTYTVKANDIVESLSEYVPKFLAALYYLQYRVDTEFGKVGGGDWASKSPNSGDFQKFLTTGNDIIGGGFSAGELKNVKGSDLVKVLREILNKYGAKGKPVHDHFRNVMLTTLGKSLDAGNTGNAVFLLPFFCELVLEDSGGTKYKPSMEKGIGPKTICWQDLTSHCVMLKETIDALMRAGFSATGIAFRPKEDVKFVTKAAEWFRENLLSTADVLKRMIPQSIRSQLNELQSFANDKLYPHGFIFDGSKQRVWAKPNKLDEWNPIFQKFLQLDEMLRKLKTILDGYNCGAAPLVTKAEAAKPTATKTEATKTEAAKPASPKAKVTLNQNNVQSGGNASTSSVGKPSSQPSGGTREPGQSVPQGDRGQQGTGGSEFSKPAASPAKQTVQPQQPIQPQPAQPPQATPPPAPASPSQPGSGGGRPNGGGGAGQKAGGSPQPGQSQSPSVQASGPPSLGASGTGGGNGQGKQPGSSVPGPPSGKDPGSKGGGTTVQQSAGSSSTNQYQSPQSPGASGSSSGKVSPSGSGQPGGNGLGSHGGDPKSTQIPSLPSPAPPQPPGVQSSGASSPDAPAPSSGQGLGDQVGSSGTTQQHGRGTSRSSTNVATTTSAGSAPGAGGGGGVGGSNGKGTAGKDQGSGKSHDQKQDEKSPLPACKNGEHPFTKSGEYKCFRKPTTRNLTNTYDNVWEDVNKITQNRTIQKNIQKNKEKQNLPPRIPPTLPTHPTPQIPPNRHTPPSRPAPGPTTQIPSTPQPPSGSPVNQRPQNVPQQRDVGRGATDAVPSEITGTIIKDTDTKKKYDKIGRRVETEQQVRKWNREAEESKVKEQAKTSFAILKANAAEEWKKQLEEGERKKKHDDAAEKMQKTLQQGDIELELKRKEKQRRMDAEREYQKSTEQYKRQLLHGMDVDTKVLNEHPRRPTYPDAARVETEVARRNAREDPMATATPIHPDKQPVDLEGDATPGSKGIPKSTFPPLSSNIGVPMSYPIKPPQTKKSKTTSYEPELTVTNIPDFNMKHRWLPPPPIVAPPTSLPPPAAPHHSALLQHDHTLQTMAAKSRDPNAFVSKAEGTPISAPDVHSSFIPTVYVEPPPPGGLQIALPDRPSPKVDDPEFFIEVAKHTLPENNLDFDLDFDDESTHIRNETPPDPVDPSFPAISFNIPPPGPEQSMPPQNDFDPDIISRPDLKMCTAPWMTQTETGDSPDIPETELFPAEAPRNVREMLTWLAGLRNEKHHGTLRQCINKAFSGLYSDPSQLALFINHAKIRPGDVFDILQLTAMFAGSVLNSIAPNWRASVPSRTVQPKSSDQSYEPDCCALLCQLRDYVYACCHQLQFLKSQCNRGKSHGGWQNCQYGRDLKTPSPLQAFLTDAYDSKFKTHLFDPCNLCLKSRIKMGFKRGDLPNTSQQGSVISTILSPSCGGDDLLLTLSSYLNCITRRTPRTTGELVSFFHHLGNSLHDMYSDTLLPLGTALAKSHADCPDWDHLGRHGLQAVSGIRGSEPLNFISKNNSSHDKDHPRTLSTLVSCGSDPDNCHPRMSPITYRAYAMYSHTFANTYLSWAVYLPDRLWESLQTLHYELNKHDSSKCTSLYLCSTALPLLYTHGFTPPEGTLQLPLKCSDVIVKLQEIVNGGPIATLLTAMDNFLYGIREPFIFTLVALWSTALLVLANTMLYHLDVLHIRSHLIRTKASHLIDVKALLTKGRKMLSLYKDVDYFDEDPIGQLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDJ1</accession>
    <name>A0A061DDJ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769655.1">
        <property type="nucleotide sequence ID" value="XM_012914201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDJ1"/>
    <dbReference type="GeneID" id="24566010"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313710"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="102" mass="11875" checksum="DBD1B9E833612A40" modified="2014-09-03" version="1">MDNITQLYSNGDVYVLGKGETMYHFTNTTQIRADDKIRYTPPKSTQQTLSRQYGFAPRLRNTKKLRRKLTREATRQPMPRAPATYKHFAALRGANQQLLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP1</accession>
    <name>A0A061DDP1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769765.1">
        <property type="nucleotide sequence ID" value="XM_012914311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP1"/>
    <dbReference type="GeneID" id="24566120"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400710"/>
    <dbReference type="OrthoDB" id="367242at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="250" mass="26940" checksum="174B585C97182010" modified="2014-09-03" version="1">MEDACDRCIAILQLQGLVAAASFAVCLFTWCKLRHCCDLTESLQQDESSDNMCTSSATTPNKSAVSSAVYAADDMALVEHLLRLRSETASADIRRKIGKHANAYADKTEQCNSALSYEFAGIYGSDKVQQADASRILSALGKIANLRHMDMLVLLKGIDPLVLKAFEPLTVLSVLCIMLAEGGAPEPADILTFFTEHEIDIPTALGAATTINCLIGRSNISASEVMEAVDAVNSAAVRRSSRIRRIKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS6</accession>
    <name>A0A061DDS6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768716.1">
        <property type="nucleotide sequence ID" value="XM_012913262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS6"/>
    <dbReference type="GeneID" id="24565071"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304340"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="104" mass="11059" checksum="C408341470217B13" modified="2014-09-03" version="1">MFRPNAAQTRCAVYALHSWSDPADRLAHKRSKIGVCAIVTANIANFCATATDSVTTGAPASGRFAPAESTVSLDTKSLQTFRADKPPRNCDINHAGSVHNAQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS9</accession>
    <name>A0A061DDS9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768726.1">
        <property type="nucleotide sequence ID" value="XM_012913272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS9"/>
    <dbReference type="GeneID" id="24565081"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304430"/>
    <dbReference type="OMA" id="SHRRCIR"/>
    <dbReference type="OrthoDB" id="366252at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="510" mass="55827" checksum="D425E3CB351167FF" modified="2014-09-03" version="1">MSEGTGSQSGEAHARPGSERRASAVLPAIPLPAPELCLLNARPLSCLYSSQYARTQRKRIRRAVTRCEASDVEDCLYNEDDNHVHYYRRSTDAGDDEPLPEATPSEIRKELQVCEALLAHIGVRIASKRNALALLGLNVMHGNRRVGFMSRALRYGVPCMPMSAMVNTLQARNANGSVPASTDDSAYPRPTPYTDISWGLEDPDLLRGKLHEVVEDALAGLGKDPDGNDAVSFKDILKLPLLTSNAYSLLGPSSLVLPDDVLSEDLLLPTLSGPGRGNGPAGKAKKKAKASESAKSVSFKAKPDIYDKPLSSPIRFIGIGIQEGAASGDATPKSPSRLRDPADGRGSSDRLKLLVSQGKVQPASKRPCGSSEDEKIASTDRRSLVSNEGEVDRADEDDGDSDYLVNGGERVKRPSRDRSRAERRDGQSKEKRNEKLPPESELTVDQMVQNLRNGKLCNGKDPKNLRDLIISILVAGLYEFLPVEFFNEFLQDRRLLQCLRQIRRRPNPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDT9</accession>
    <name>A0A061DDT9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769870.1">
        <property type="nucleotide sequence ID" value="XM_012914416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDT9"/>
    <dbReference type="STRING" id="5866.A0A061DDT9"/>
    <dbReference type="GeneID" id="24566225"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401755"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401755"/>
    <dbReference type="OMA" id="TQPTIFW"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="21585" checksum="4B5C8FE3CC5968F7" modified="2014-09-03" version="1">MEVDAETEKRPKLESAEEHVAGHKRILRTSILGHLQRAKDALAKEREKESVSVFSGSTMRAQTIKHMEKEQLVASKLADQERTKLEQLSHELRAQMAASEEQLRAVESELNVKCNELMVSVHVSTAKRAQKTSLTQHYEHMANFIATQAQPTIFWAPRNFNPELESLRGRTQQFISEKVAAIASTEYFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDV0</accession>
    <name>A0A061DDV0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0304980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768781.1">
        <property type="nucleotide sequence ID" value="XM_012913327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDV0"/>
    <dbReference type="STRING" id="5866.A0A061DDV0"/>
    <dbReference type="GeneID" id="24565136"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304980"/>
    <dbReference type="OMA" id="KCYCVSC"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000003">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="115" mass="13294" checksum="58A567668215BA42" modified="2014-09-03" version="1">MPFKRRNGGRSKHARGRVRPIRCSNCGRSVPKDKAIKRFNVRNIVDASSQRDIKEACAFSTFNLPKLYIKQCYCVSCAIHSRVVRVRSAEARKIRTYVQPRSSHMRINMPQSKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE40</accession>
    <name>A0A061DE40_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768981.1">
        <property type="nucleotide sequence ID" value="XM_012913527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE40"/>
    <dbReference type="STRING" id="5866.A0A061DE40"/>
    <dbReference type="GeneID" id="24565336"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306990"/>
    <dbReference type="OrthoDB" id="10356745at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="278" mass="31749" checksum="3AFAA0D0E543FD13" modified="2014-09-03" version="1">MVPHIILGGIAGCLFAYYSCRVVGFQGNRMVVDSLMKNVKYDGEATVAFVISYPGDESRFFTPLMELLRLRANDPEKRFKLAVLTLVPGELGVSTITCAAAKYNPDALQRIIEMQGVCRKYNMICLLEHHPLEGDEATNFWKPSVVADRIVDFLEENKARHLFTFDKFGMDGDRARIAVHQGVMELTSKMPSCHIWLLHSYSKVYNALPLLATMKAAFGGGYRVVLYSPFEVTKNMRIHRSQWLWDTTFWAFWSPYSYSNIYERLDSDDASSYVYVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE47</accession>
    <name>A0A061DE47_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0307190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769001.1">
        <property type="nucleotide sequence ID" value="XM_012913547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE47"/>
    <dbReference type="GeneID" id="24565356"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307190"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="827"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="957" mass="107928" checksum="F7B9781C8B365BE7" modified="2014-09-03" version="1">MAKFIGAQLAICAIILQFIGFIDAFESVLRNFGNRLISNALVAFHINMDDIGMATLACPRQVNGTEYVWHPQPTADHDNTLTTYVIEDGKFRSVPFSKVVVTEAPRPYVRKVPKESQTELHIDLMDDHIYAITENRFALICGPRNLVLSEALQAQLARRRHIYEREVYIWDQTVPLVDEIAKTGKSLGVVFLHRGRKHKLMQGCGSRPSPLFASDNVTVDSETGTRSCMVDPMSELPIGFICQGRIEPDDCMKYLLGKTDGVVTAPTPHLYRNLNNRGKWVIAQYYNGLALRAFNGECRCIDPKTGRVKARIEVRWKTEYICDITSMIARNRFNPISGPWCSVMLHPGATLTIKLPKQTVKSAAADLEFEEDGDIDEDALRVPYSQLPSTHAYETAFKPDTALTLRQIQTISAIDHYDEILIHEAFTGNVLDVDVSQMERGEVKLKYRIDRPLALRRGCNSFLYHWTFISRNQYVLEKIRAVVNVSFAPTYRHDIIGCDRWRPGMFNPANDIGSLAIRDMGNGIGLTSEWLVSVMSGKKQAGIRCGDNEELLPNNCESTGYDLSSNQIAPFPTSVRNATLYPIRGFQVFEMSFQNVPVSHSCSCVNEHGYETSRLILRSNRREGYMYTVRREEAYRRLMPYSLLPWTEVALFYGVSNPMRSIVLHNMPHRPIKLHSGTEFFMRCVMSHALYNGENNAAAIPTWLPDDPGYNHYKVDTTADGHRLIRKPHEERIAGTRGGFTIILSEYTEEYCGLMIKSNSGAILVSRDPDHSEYVPMTFVCGKELSETDFGPINDGAYADTIPQVIAPLEEYTWNVVQIDVEMTDPYMQGCGITDSRDMLFKPETFKINDAEGKEIGCKIDIQAANEAAFYCPAPYILDPPDCFNQVYVDGKVMNIGDISQSLVASHSNHFVTLKFNSELIGPGETLRKTPPLECRCVTTKGVVLSTIQIENYYAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE53</accession>
    <name>A0A061DE53_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770175.1">
        <property type="nucleotide sequence ID" value="XM_012914721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE53"/>
    <dbReference type="GeneID" id="24566530"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404750"/>
    <dbReference type="OMA" id="KTLQNMH"/>
    <dbReference type="OrthoDB" id="365447at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="686" mass="75112" checksum="E96DCF7DD14AA5C2" modified="2014-09-03" version="1">MAQVDAVGDAAAIEQEREMQRLNLERLFTDTDEMTVMKTLQNMHLANYQLENGMKDVMTQELEPIKLYSGNMLGMCSLVREAQASLNDLALHSRTFDLKRPSEGDAASEPVAEYDLKQFIGRCGEVRDKDGVFGEGSEEGEGHNRGDIIMRSVHTLQNLSMENFRLLKRNMFLKSFKLIGMAPSLISLVEQLVECSDLTGPGAPAETQAAGRTPNVETTQGGVDKSDFVAYLESGRRQISGAMDPQHLKAMLERIPSIVKYNTSLLLRKCEAALGSSSLATLMEASLCLLMQKGRYSQDPNRLWTHRLKALKGDANKAAVACTAGCEWLLAHQLASAMYWLFCRNMNPGALAILKRILGAPLPDENDEISPPKPAEHTNFMEEACWKEAMELIVGNAKKAELDDVVDFNQRLQVVVVAVLKSVEQNQLLLSVYSLLGLDLGQELLKAATEVLQKIKAACNEAASESTLKLVADIEQRLQAHEVCTAQIKALSNYASRGDNGVVDAFTARMSEVVNKWQTDVREMEGPAAGDGILGTYGEEGSVRLWLHKTGLGNLVLNAEAIWPQMEAAVRELLESVAAKCVMPLEGGDRVVRTLVGTGALSSQYNLLGATAFPLCIKKACLQYWISKAGDIDEKDKAVLVLCFRDAGLAEAAKDLAEGCETLASELGDEKIEEHAQAYQTVRNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE9</accession>
    <name>A0A061DEE9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769346.1">
        <property type="nucleotide sequence ID" value="XM_012913892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEE9"/>
    <dbReference type="GeneID" id="24565701"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310630"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="64" mass="7282" checksum="0FA175A64DA31795" modified="2014-09-03" version="1">MHNIIHIQQVVIQETHKIVMRDMKPKEDYDSVEDPQAQTGWMPAWMAPVTTGNGPTWNPQPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEJ0</accession>
    <name>A0A061DEJ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmodium falciparum CPW-WPC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769551.1">
        <property type="nucleotide sequence ID" value="XM_012914097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEJ0"/>
    <dbReference type="GeneID" id="24565906"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312680"/>
    <dbReference type="OMA" id="FAWKCEV"/>
    <dbReference type="OrthoDB" id="361898at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006387">
        <property type="entry name" value="CPW_WPC_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01492">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09717">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01099">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="290" mass="32770" checksum="C52F8735C99F057E" modified="2014-09-03" version="1">MQRRHKLITNASISHINLSRRRKPRRRQSPSRSMCAVSWASKHSRDVQELSEQVEEVAEEGESEEADLDTKAAHEKRQEKFEKLYQNALQNGLEEAKKEYKEFEHGAVEGLDLVGLASEHLKQFWYIGQCRRNYSLPCPNEWSWDDSEKVCTAPADYDGPCEKRKSFDDMDSKAREDYAWRCHASWPCMNDTPIDDSKLCPLEWTKVASTVCIAPTSYDGVCSPIASFQGLSVLEKLKLEHLCSIRWPRLTPEYANQSDIGATAGYAAAGSSSWPSGTIDETGAMVPLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEQ8</accession>
    <name>A0A061DEQ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769891.1">
        <property type="nucleotide sequence ID" value="XM_012914437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEQ8"/>
    <dbReference type="STRING" id="5866.A0A061DEQ8"/>
    <dbReference type="GeneID" id="24566246"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401970"/>
    <dbReference type="OMA" id="FFYPMEK"/>
    <dbReference type="OrthoDB" id="409663at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="134" mass="15656" checksum="66FDE9978AD2A27C" modified="2014-09-03" version="1">MLNLLPKRNPAVSLLYGKTGIQRIRVGKDRKVVEIDRSAIDEMYKHARDDVELHNDYVPMKHRNYMEYKLDGYHLIEAYENPDKCHRTPLAGAKLFDKLRDTYTGKLQQTCAKVIKEVSEPFFSYPIQGRNIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEV6</accession>
    <name>A0A061DEV6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0404330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770131.1">
        <property type="nucleotide sequence ID" value="XM_012914677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEV6"/>
    <dbReference type="STRING" id="5866.A0A061DEV6"/>
    <dbReference type="GeneID" id="24566486"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404330"/>
    <dbReference type="OMA" id="NKKDNFW"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="13">
        <location>
            <begin position="23"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="984" mass="108967" checksum="BDDF33706C341C64" modified="2014-09-03" version="1">MTSGEEGAAGSSKGHNDLGFEVNSSGWVRSEFIRHFERAGHVFWKSSPVLPHNDPTLLFANAGMNQFKDIITGKADATTEYGRLRRVCNSQKCIRAGGKHNDLDDVGRDTYHHTFFEMLGNWSFGDYFKKEAIDYAWELLTKVYKLDTSRIYITYYGGDPKLPACKPDEETRDLWARYMPPERILPFGMKENFWEMADTGPCGPSSEIHYDHVGGRDATHLVNADDPMVVELWNLVFMQYNRKSDGSVELLPKPCVDTGMGLERVTAVLKGSYSNYDCDLFTDIFAYINKLMPHLPPYGGSDSIVDVAYRVVADHARCLTVAIADGVEPSNDGRGYVLRRILRRAVRYGKEHLGATGPFLSKLVECVVSSLGGAFPEIQNQNDKITSTIHNEELLFLETLDKGCDRFRKTVAKLQASSDGSAPVVVSGADAFLLYSSFGFPLDLTQLMAREMGVDVDVDGFNEHFKRHQMLSEKKQVKSDDPVEQGMADLLASLSADVLATISNAIGGRATDDSLKYQGIEKGYTDNLEFDVQVLARWTLGGLNQPLQDGEVFAVVLDRTPFYSESGGQIWDEGLLGPFRVLKVLKMAGMVFHFCVCEAGGDELCRPGATLKARVDYERRVKVACNHSGTHLLNFVLREVYDEKSYQRGSQLDAEKLKFDIAASKALDDETLQRIESRLQEIIDADWKVEVKELPFKEAAEIPGIRANFTDVYPETVRVVSMAKAGEKADGNVNSIEICGGTHVPSTGVLKSVIVVGEEGISKGVRRLTLATHDQSESSKAILSSYKQRLADLESRLYKFTDGMDTAVMAQQANENMKQLTALRFEMQSEKLLPLLGKRDLKATFDAMINAQIDAGKVHQKKLGVVAKNLSTEYLARFKTGEFGDAKITRSGMELIRMTVDVLEGDVKALNVFTQTLAKAYPKFAFLITSSHANRKCVACRCVVPAGSDVDALVLANEAAESFSLQPDIARGSKTNASWNVESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEX6</accession>
    <name>A0A061DEX6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0405290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770231.1">
        <property type="nucleotide sequence ID" value="XM_012914777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEX6"/>
    <dbReference type="STRING" id="5866.A0A061DEX6"/>
    <dbReference type="GeneID" id="24566586"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405290"/>
    <dbReference type="OMA" id="QIPAQKD"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="45"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="479"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR98045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="551" mass="61651" checksum="FB8B479D87EB3A25" modified="2014-09-03" version="1">MSLSFYRLHRCLLQHNLQSVLPKRRLTYAAASRGFSSNSDNEQKKQVVVLGTGWSSLYFVKNLDLTKFDLTVVSPRNYFTFTPLLPKLSAGKISPVTCTEPFAAFMQKHKRGNFNFVHARCLDVRPDEYYVDCVSVHDAERKLSIPYDYLVVAVGAESNTFSIPGVEEHAYFLKEVEHAESIYQKIVSNFEAASLPNTSDEEKRRLLHMIVVGGGPTGVEMTGEVAVLFNKYMARTFPSLARFAKVTIVEGGQRLLATFGAGNSRFTDRVLRNNNVNVMLGKQVCAVGKDDCTVRDVVTGETERLPCGMVVWASGLKSSDVVVQIQKHFKEQDNPRALLVDQYLALRGSADRSIFAVGDCCKVTPDKLADSIDDVIQSIGSTEINALLKSRKELVKRFPQLASNKLNTSERAFKELCKRVRRSSGTDREKLLEIMEHIDNNYASPFPTAQNAKQESLYLAEAFNRGFAASDSHAFNEAWKGSLASIGGRNVVGNFPYFQLNGGITTLILWLAVYIRMFSSNKMRLSYIADSVIQKICGRHIISKQSENNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYU6</accession>
    <name>A0A061CYU6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765972.1">
        <property type="nucleotide sequence ID" value="XM_012910518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYU6"/>
    <dbReference type="GeneID" id="24562327"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101150"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="118" mass="13080" checksum="45A7F8B6FDB2DD9D" modified="2014-09-03" version="1">MLEFVGRFILAAPPCYPAAHESQWLLSVSPKLPKYLDTKCSSSHAPRGRTKWLLSASGSPDLKVASANQRNTRSHGCRRPKYKLYTLTVSHNRPLMSVSTKRDTAPSNSHTKESKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYZ7</accession>
    <name>A0A061CYZ7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0100070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765864.1">
        <property type="nucleotide sequence ID" value="XM_012910410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYZ7"/>
    <dbReference type="STRING" id="5866.A0A061CYZ7"/>
    <dbReference type="GeneID" id="24562219"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100070"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="431" mass="48802" checksum="F8B2678818CE8045" modified="2014-09-03" version="1">MAESDKNIEQWKIKQLIRSLEAAKGNGTSMISLIIRPKDEIPRITKMLADEYGTASNIKSRVNRLSVLGAITSTQQKLKLYNRTPPNGLVLYCGTVITDDGKEKRVSLDFEPFKPINTSLYLCDNKFHVEALKELLESDDKFGFIIMDGNGALYGTLQGSSKEILHTFTVDLPKKHGRGGQSALRFARLRMERRHNYVRKVAENAVLMFITNDKVNVTGLILAGSADFKNDLMGSDMFDPRLSAKVIKIVDVSYGGENGFQQAIELSAECLSNVKFIQEKKLIMRFFEEISQDTGKYVFGAKETVNALENGTVETLIVYEALEVMRVVLKHPQTGEETVLFLTNDQERRDEHFKDTKNNVDLETVERKPLTEWIVENYSNYGAALHFVSNKSQEGAQFHMGFGGIGGFLRYKMDMAEYYDDQIEDDDDNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZB6</accession>
    <name>A0A061CZB6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0100920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765949.1">
        <property type="nucleotide sequence ID" value="XM_012910495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZB6"/>
    <dbReference type="STRING" id="5866.A0A061CZB6"/>
    <dbReference type="GeneID" id="24562304"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100920"/>
    <dbReference type="OMA" id="CLMQCFL"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031724">
        <property type="entry name" value="EELM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15863">
        <property type="entry name" value="EELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="6">
        <location>
            <begin position="218"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="41776" checksum="40CA740923A7C078" modified="2014-09-03" version="1">MLYDVAHVLSSHVSLDDGSVFPNGSSDVPEDEVLSCSSVDDSENACSLDTSLSLKHSLMNEDESAPDCIAPFGDASPTTAIMDCPASCAECGIPAGPFLACGACELLYHSKCLMQCFLPTGEGSWKCPQCQWKLINAGEVPLDSSLTQCDLSDDSHTGYDGLRSPVGHDEVSDEASGLEKEPKIKVSRPGGSPRRDRSPDIMERKRKKPVTEGSNFQTKIHVGFSHQVPFTPAFFLDESQSPRRENNDWARLMYSPYYLEKIRARKILEGAEESVIKNEFELAEFIQLCAQNWKSNPGWHPFSPEFAYKILHFADYDPKKALRVMNDPNFNFICKLLGPRRRQPAQVSVTLPPVDTTTSGSPRTVVARCQRAHTRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZC1</accession>
    <name>A0A061CZC1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sialic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0100970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765954.1">
        <property type="nucleotide sequence ID" value="XM_012910500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZC1"/>
    <dbReference type="GeneID" id="24562309"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100970"/>
    <dbReference type="OMA" id="WTLFRVA"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR93768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="460" mass="50244" checksum="E2A3A5ADD05A9741" modified="2014-09-03" version="1">MKRPQTPSAGAGTAPKVEHDAVGKSLYSLVSLVEGFDQHMLCMCMRAFEASLGLNQSQLSTLMTVSNISRLGCCLIWGLLADKYKLNHVFAAGLLWMGIFSIIQSSTSDYKSIIILRILHGFAFACIYPVQQKIVAEDYSDVSCNLIFGTMQALNCIGSLVCAVVTTRIARQVILGHYGWRTAYVVLGYVWILFGIAIMYGMTRGKSEKERCNAKDKTDVKEVIEVAFSAVFYCKTAGISIFTLFVAETPTCAISNMALYLQYLGVSDAMAGVAVATTMIGCALGSGVGGLIIKYISENYERRGELYSGIAVLVIRLILCLLFFLWKPPCGTLCWYHYMELAAFGGTLVTVGGVDRALLKKAIEDKCQATAAAVIRTISGIASIVILFQISTYLSENVFGYIPSTAPFETMQVSIKHRNAEALKLSMMYIIVAGTILNIFCYVALLCYAPEREGDKGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZD1</accession>
    <name>A0A061CZD1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766167.1">
        <property type="nucleotide sequence ID" value="XM_012910713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562522"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103030"/>
    <dbReference type="OMA" id="ANVHESI"/>
    <dbReference type="OrthoDB" id="366472at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1366" mass="147184" checksum="DBA07E999E5AFD82" modified="2014-09-03" version="1">MEPPASPRKGQKAHTGVDRPLVIEELETPHDRASVINGAVKYLAGSGSARYPLGYSNQTTDEFFPCEEDGVEGDGYHRESYFEATLPEPEDSSDADSDIHYVKQICRQGLPAGGTGLKESSSYHTPSVVTCSRYSESSSSITHLDSGNFAPLVNTCRRPSVTLETTKGALNCGNQPCHTVLLESTIPNMAYHSIDGDFFDERAGLSSNAFHLPKAVDSILEGADMCNRRNLAGVMHGSSRRQSFQEMCAPPKVGSNPVASLPSDLMSFAKDFRARYGAAAPTGALDSSKSGNNVRNAGAKRGENVGSLPCAGSAAAHLDQRSLATPSRRTGMGGLSMGYMPTDTASFYDNAKCGEYGANRASFGSVTGANQGAALQMPFVRRPDLKIRQLGHNQSCDILLRDYKSPISRESVAADGVGASPCRPKEGYAREAHDRQVNGGKIGVMSENKFVLPYEDPAQRSVSARDSAPNRGIQGILQHNVKSPLRGTLHSSDYSREKSRNRTQTTAASRHEEPYSSLAANAAKARLDIDSAGVERPPADNAFSLADVNRQIDEFFVSRMNPTAPAKETAITSPPGRHGYTAHHPASSPHPGNGSLDMYDSSVIAGSTAMPYSYASKLSTSENAAHGRVTVTDAVVQPDVGNINTALVTPPSERSVSVATPNPASMEHVYYSRAEFTKNAVSQPTSRDAKWVPDSLPSTSDPRGIPTAGVDIGDVLLGQDAVDYQVLPTTARNASDIKLYDSARLDLPEAPCVDTVAVKVPLSVGKNHADGREVTPLHVGEVETALECTPADNEFDENVPTRTNHVEVNSTGELTRMATLMSFGDELGSYVPGDRLAPEISNAAVEGGIFASGILDHRAPKDSLDLRAPKTGFIFNKENLNASYGLSNSSVGVGFMKGGEHAPRNRGSLRSSYADSLDAIFDHDSLCNSQQDHKNLTGRIAANPMVERVHNVAAHPVVREAYRSSLDGRPQSSLCARCGHNTTDRETAYRDEPSHSKHGKSKLSDAHRCRRSSMASVTVPASANVCTGRGNFEDDRSVASSDYVQVPLDEENDAAASYGQNTYFCGSDDTLKPPAAESTVQDKALMTSIENILSRHVESAGSLEHFSALIKQLHEAIEGKNVKDKDSKQPPQPEVEKCITTANRPSGDNEVKQLHFSVGQQTSAEQSQNDGVRTERKAGTKFCATAGTQTYDFDFNEGPVGVSKGCNSVYFKVDSSDDAVRYNTNRKERHVSDVATNTPKWPSWYKDSKHTHAAVRAASDEPSPPLTREALIKRMTDASEELPRVNRASGNRRSFPLADYESDDDTRTGRKGGPSVTAARTTSLPNGLTEEELLDVYNEVMKLTRILHVKDVKSLTRAVTARMHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZJ3</accession>
    <name>A0A061CZJ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766232.1">
        <property type="nucleotide sequence ID" value="XM_012910778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZJ3"/>
    <dbReference type="GeneID" id="24562587"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103600"/>
    <dbReference type="OMA" id="FESRWNR"/>
    <dbReference type="OrthoDB" id="390489at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="165" mass="18812" checksum="CDBD3CAE9BC4D166" modified="2014-09-03" version="1">MGLLSRIGRGFRGLGEELLDCYAYATLRQQHLMMVCAGVVLGAIVGVKSRRQRLASGEFSDNLELVAYSTSSVDEFESRWNRLARFAQRRPDYKHTQLYKAIDWDKPFPHYLQLRLWKYDDSLAKFTEAASSTGLLKKVDMSATSVQRARPVTIIDDSVRRGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZL0</accession>
    <name>A0A061CZL0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766014.1">
        <property type="nucleotide sequence ID" value="XM_012910560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZL0"/>
    <dbReference type="GeneID" id="24562369"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101570"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="9667" checksum="BD6E9C7055B1EEDE" modified="2014-09-03" version="1">MRLLLLDVSVYSKGEVHKEGRKHCVNVVPVFSSARLSHSSCPRCHLHVAIPAGTKSYLQASFTLRIMVFRRKILCTILTACTERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D040</accession>
    <name>A0A061D040_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0103520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766224.1">
        <property type="nucleotide sequence ID" value="XM_012910770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D040"/>
    <dbReference type="STRING" id="5866.A0A061D040"/>
    <dbReference type="GeneID" id="24562579"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103520"/>
    <dbReference type="OMA" id="YMENESI"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="319" mass="35362" checksum="988EB64E47D6DE97" modified="2014-09-03" version="1">MVSAAGAITSPLLHYGTCQDVYLSCDSSGKHYALKRIYREDLEHLRRYRNSSGRLVRQSWFADLRRSISIQLLVQHERCVRCVCVSGFDLHMEDESAVGNEIDLVLEWCECGSLMELDSSAKIPHIPRDVLRCIAHDVIQALDYLASIKVAHGDVKPDNVFMEASGRCKLGDFSQSQMMTSDGQVTGARGSYYFLAPEIASNASDSYDGSAADMWAFGSSLWMLYFRRYPLRDPLSAPMELLANIAQFDIDNELACVRAAGESIDPEFESFIRGVLCKDPRSRLRPQAALSHPWLSSPNFAAAAAYAEGLLSGNDVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D072</accession>
    <name>A0A061D072_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766417.1">
        <property type="nucleotide sequence ID" value="XM_012910963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D072"/>
    <dbReference type="STRING" id="5866.A0A061D072"/>
    <dbReference type="GeneID" id="24562772"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105400"/>
    <dbReference type="OMA" id="RRQLKMW"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="591" mass="68398" checksum="1A11D90EF240736F" modified="2014-09-03" version="1">MEECFFNYLRLLGEPVWRRLFRRRAPLRAILRSLGELEQLIILRLLNIRQAVSERALRLWMNPNSFTDLRAALSLLQSYHIIQVSDNRTKEGKQQFELHKEFKTSMLAELYDTSTDFDSGLQLLGNINNNAQKDPKSKPSFATLVKHSKERLDFLVLFLVSSQVRRHTLRANKIAKKLKKLEKSKDPNVKNPLLNKKIKSLEHQLTALSKRANVVSMDLLKIFQRFNMISEDNKKNKVHGADAGMSRQALSWLLKGVHGQLIILLVGHLQQMEGGYLTNISGRKPTQLDLYTRECRDISADNDKASAERVELAITTITESVDFLLSLSQARSGDMFSIVSLTKTQQRLVKLLTEMGILYVDSTKGYFYVFDLTFLVGRNESDVNRTPRLSMSICGTTDSKIVVQSNFKVYVYTANALQISVLSHVCELQARTPNLVIGVLTRSSVQAAFKSGITAEQIIRFFESKSQHEDTNISALAMRVPENVRRQLKMWEAERNRLELINAILFKRWDTEFMPELFKRTVRWAQVKRYDLFHTRWPPDLYSQDYQTWLKNEKYLACTFESKEEVIDKIKQIRMSLAEEKTRITSDPTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0M7</accession>
    <name>A0A061D0M7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766394.1">
        <property type="nucleotide sequence ID" value="XM_012910940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0M7"/>
    <dbReference type="STRING" id="5866.A0A061D0M7"/>
    <dbReference type="GeneID" id="24562749"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105170"/>
    <dbReference type="OMA" id="NCLFELI"/>
    <dbReference type="OrthoDB" id="365734at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="352"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="581" mass="65850" checksum="F1E2325CB9F61DF2" modified="2014-09-03" version="1">MSPKDVVLSELAKGSNELNKTLGTTSIEVVFQKIDHLVEKIFVAKADIRCFFDRQFFTCGTKPGCDGNTNESKTRHASVKLRQICFNFFRTVTTLSQKEGYTIHLIPRLFTVLRLEISLRDLDPKGDEANKDVGNPFPLPLLEYIIGLMLHSVDYDDGIIENVLHDYVVSSNEWIYNAYSVLENILKDFVVPHFNLYKNESVSSNLFFARCVSFLLTLPTPQLSHRLNDTSAPDSGAVFEHSDANDGYDSDSDIDYGSVSSGEDDADVSVSSESVEAHVSATVTGLQWPFNFTKVYAAVWQGVIFANIPMSTELLARIMSRMPTAILPYTKTPVIYANWLIGHLHGDDKVLSMLSLGSIFELILKYGLAELDCMCADGNLQSSISEFYGLLYRNINTFVINCKFGTQFLCFLNMALKSTMMPSRMTMKFIKKIIRMSCFTNSMKSAALLVIAFNLLKRHAQTYLNIVHWDTIKEANRTRDVSDMDILTNVVESNDDEIVTAFLWELPLLMNHFNERSAVIASTFFSDLKRKRSTLLRAEDVILSDSRDHLRQDLVRTCREDTHAFRKKLQKKTKLSSKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D102</accession>
    <name>A0A061D102_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766474.1">
        <property type="nucleotide sequence ID" value="XM_012911020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D102"/>
    <dbReference type="GeneID" id="24562829"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105970"/>
    <dbReference type="OMA" id="SNMLSMQ"/>
    <dbReference type="OrthoDB" id="360805at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="473" mass="52880" checksum="B8A330312201E447" modified="2014-09-03" version="1">MLRSLLLSETSAIRYTLHSSNRWPTGALSRKSHHASAAIIKAYELNASKQENGLQSTEAIRDQLRSLRGATLSKQEAFLALQFCLRVGYFEKDLLSNCMCLVESGYYNPVLKTPWNGDDSPPLKNVSELPNNCFDAVNGMPISDKATMWQDRLMKMRRTPRGQRETHTSRGITDVDPEKREIFTTRKLGKVVDPKPLRVRVRDMPPGKKLCSAVAFQLREAVDGASLTELGDISTMFAARLPLSGQLNDDTMELLAERLGYYTPEELATQISHIAIVSSAATARYVETWSHRRALGSTRASQAHRLYRIGRKTLPKQFLTKLSVAAELYARERVTPVALGFRLGYHMDATEQQFFTLRSLARSDTPLSMTQWDLLLASAEESLDGDAEVNARCVIWLLDAINAAKYTTLSTIHLARMLTAKCEIASDVDRNHTHVDTFDVKPMLRFVEENSLGDDAKRIIKAVAGVNDSISDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1N2</accession>
    <name>A0A061D1N2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0103510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766223.1">
        <property type="nucleotide sequence ID" value="XM_012910769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1N2"/>
    <dbReference type="STRING" id="5866.A0A061D1N2"/>
    <dbReference type="GeneID" id="24562578"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103510"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="344" mass="40377" checksum="1163D942DDAEBB5E" modified="2014-09-03" version="1">MAEEKRHNKYRRDKPWDDETVDHWKIEPFPEEDNKPPLLEESSFATLFPKYREKYLQSVWGDVKRALAAYHIKCELDLVEGSMTVFTTRKTWDPYIIIKARDMIKLLARSVPFPQAKRILEDGVFCDIVKIGGILRNKEKFVKRRQRLVGPGGSTLKALELLTQCYILTQGQTVSIIGSIKGIKIARRIVEDCMRNVHPVYHIKELMIKRELEKDETLKNENWERFLPQFKKRTVKRKKVKIVKKKSTGLLLPEQTPRKEDLLLESGEYFMLEEERQRRKQLEKLETQRSKGAEKRRRKAEAYDPEHNKIATPSEEKVREAPESEEPIVALHKGAKKKKASAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1S7</accession>
    <name>A0A061D1S7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766784.1">
        <property type="nucleotide sequence ID" value="XM_012911330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1S7"/>
    <dbReference type="GeneID" id="24563139"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108960"/>
    <dbReference type="OrthoDB" id="366471at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117616" checksum="AE97FE23DC8CC053" modified="2014-09-03" version="1">MEIDPTVVQIYVLYSTSKQSMPPPRSGVPGGVYASVMDWIINNRRRDDYERDAAPVAEKKQSPEKVLKQVWTPVSHLSHFALLYHEDDIIKRNSSVKRRKFKTVASLAKYVDAFNSYKKATVSPPLANKLDHKLKAGTRTGEHDKGKKPVVPIRNVTEGAKEVISTQPKDAKGAGRNQGTGTSNVEGANQLDIKASKDNKVTVPNITPAQSQQKARKNDGNGHEKDSNPEASMASASIPAVKATRATPESKVSSTNAQSKQPKHGVVAKVAPVRQSPPATGSKVKSGTGYAHEGSKTATSNKPHGNTIAAVSKDNVAGTLNSRRNPVKVEPGSSGKNVRLPAKPAKATPPSIPPKPTPRTSVRSRPAASGSAGVKPDKPVHGRQNPQKPVEHKVVDKQDSHSEVLPDHDASGIKDVSAVTYAGNDTSSEAGSAAVGNVTSDTHQDTSPWQPVVELNPVIDPFERDTWMRKAMVRRRKSKSESKEDESNEGASVVDGIDTVGNAEAHLCDDIAHTPPGEESSNSSFARCDNQSIDGHSTSCDAETASRRLLSARMYDMFDEDVDDGYAVDTYLEYADVYMGPSGAYVDGEGSSIYADDRDITTTRVAYNTQLVRRENNGDSLIHTGTQDNVDSLAPGDNNLSTASPPQATSGLRPSSVSSPVNYASGSNHDTITSNNDSSSGLMHESLQAPELSKNDSYSDDVGPPPSCALCLSDVRSACCDVECNDAVTRILNSASLGLRNPMRQLCRSSSCKVLDDFISEYDVDESFRTYSSRRFESWVPNIKNILRELGGIEHFRDDGYVYDIDRGLVADIVDWHDMGPYGTYFPPNLVLQTSRDFISVEFEGSDGNVNVAHRELGGWFEPQAMVVLRSRNTIHRDAGWALSADPEGEENVDVEIVPEERRRVDASVDLEDAYLDAISPTTPTPMRYPLWYYVYMKTGFNSGASMRSSTYQKLLNAYEAYVKRTKRDISGDNSAIESRSSTIAGELLRNMAESSHLPIADSLDAISVLQQAYGNMLTCLGGLHSGRIIHETTLHVSRRDYIFNVIVAWSCLAALITIISLATVVSIQLKQRTARFTSTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2C7</accession>
    <name>A0A061D2C7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767102.1">
        <property type="nucleotide sequence ID" value="XM_012911648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2C7"/>
    <dbReference type="GeneID" id="24563457"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200730"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="9366" checksum="37B4F87671ADDDE0" modified="2014-09-03" version="1">MFINLLKAFVYISYNGPLDTMEAAVKEGNAEALRKSMMHIFVASTFLSLVCYCALFSHATDRVSSEQKRLKKREKERVSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2I3</accession>
    <name>A0A061D2I3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766974.1">
        <property type="nucleotide sequence ID" value="XM_012911520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2I3"/>
    <dbReference type="GeneID" id="24563329"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110850"/>
    <dbReference type="OMA" id="CIMRECA"/>
    <dbReference type="OrthoDB" id="365990at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595904" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="171" mass="18843" checksum="15E8735AD82D5576" modified="2014-09-03" version="1">MRRLPALFALLFAALLGASGDIISDEDCFAESAERAIDKLSQSGNPDFLEEVKAFKHSPFLLAVRYCLGPEASNSSQDFVSCILSFSSCSRGGMEVVDWELCACDTFYCIMRECAQRWLEDMGISDLSCIKPCLENNSNCIVRQTGALGRLALPPVKERRGPNPYETTPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D310</accession>
    <name>A0A061D310_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767189.1">
        <property type="nucleotide sequence ID" value="XM_012911735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D310"/>
    <dbReference type="GeneID" id="24563544"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201600"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="237" mass="26791" checksum="286D3ADE692F7386" modified="2014-09-03" version="1">MCGIWRVLSFNAVCKQIIELAVEDNRHYAEPTAGCILMGVRLLACLLFLETPPFGTLLWYHLVELATLGATYDTANGVYRPVMTNVIKHRYHATRTGITKCLSGYVGAITYGSMFINLLKAFGHISYNGPLDTVEAAVKEVNAEAIRKSMMYLIVSSTLLSLVCYFALFSHATDRVPSEQERLKKREKEKKTEQNKMTNSKNMKRCPKEQRLRLTNRRSHSVLSLQGHSNIIATRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D329</accession>
    <name>A0A061D329_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767357.1">
        <property type="nucleotide sequence ID" value="XM_012911903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D329"/>
    <dbReference type="GeneID" id="24563712"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203280"/>
    <dbReference type="OMA" id="EYKGRIW"/>
    <dbReference type="OrthoDB" id="365968at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="506" mass="57168" checksum="36322FABDC8F49ED" modified="2014-09-03" version="1">MDDNKLPMKSGSPGQGLMHAPGAFGFDANYIKHMQGPSARRPQDVNVQMPRFAQQGQGMVNNDAGAFESLASHPGLRVQLPSHDQLSPPAAGKFEEGRNPQLMLPGDHDGAPMVKQQIRFPPQVNFNSAFAPNMMNYGVVAVSPMIRFPAAKQSMEHFYPHMDAEVKQMDPALSLSQVTKQQVPPPLVKPQMPPANGNVGALDKYQQQLSIKEEPVPAVSYHDCNGGVVYDKGPFSQGGRWLVFWECRGRMWRRSFLVKVYGKDGSKELAEQFWVTKMRSMQLYKANQQTAPPAEVDMWTGTGQRLNKPKKRATSTPPPSADAVAGVDNAAEQQLPQEDNEVFWDADSNSWCFECLDTATNTITLKRLPVSDSAQMEDVKKEAIQQRVDHWRDVVKAYTETEYCGHSYERTRTCWRVSHWVPSKGINRNRYFNISKYGYLDAKDKSRMYRLMVHDLGGEEPESFPFDAVPPPEFFEDPVTKFYHRILYSMRGKDRGWTADSKQMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3S1</accession>
    <name>A0A061D3S1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767537.1">
        <property type="nucleotide sequence ID" value="XM_012912083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563892"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205090"/>
    <dbReference type="OMA" id="TRGMKNE"/>
    <dbReference type="OrthoDB" id="341860at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1978" mass="222692" checksum="9ED9C66B43C7AD0D" modified="2014-09-03" version="1">MGLDELSVAQQELLHPLIKLKRKTSRESLGSLSELVSGLSRLYNEFADGIHQLELKASNFSFLTGVSNPSSSEALRQIRSDISYSDETVHLITKEQKGLYAVWTAIFRLLSLTRKDASQFASLLTQSVCDPLTLLCDEFSEGFHEPVDQLEMSDVLNFIPNLKTLRMAPAFHHCGARKYVENVLKAYRDLQQSLENEKEVVGDAIGINDGKSQAKAVNKTVKAKISLGKHIQQLFEQAPAMKILISKGVSKDVIEKLATLKLRKTPHTVGEIQTNPADFHERFCSLEKRRLSVFSSCLQILVEALVNYDRSSYNNLSELYQATVEFSPEADYGQFESLILGARVSHTSGHSRIFDEIWLPKEFGQLDTLKVGKQSSVYPVLHQSTEVEDFNDDSETVVDAPITSPSKGDKRRQVAMVVRDIEPSISGVDDSSGSGVLQSSNALESHTTPKILGIATSGTSDAMEHPTTLTDGYIDCSKNGTSVLSSHGNLEGSTNVGDTSTATRDIHPDGTMQPEKEPHLLSPQVVQPVRSAGEICQGSGRVSRDSNVIGRNHENYEAPQEHSTEKVDTARVENMYECVLRCGRDNKGGTPGIRRSSSALPCYVRNISIPLYKHIRHDKKNHGVSENKEHGNHEHVEPEKKRGNRKYKDTDSSLPNMKYDNEHVTNNPEEPSKGCINFDFETFKTAKEILLATLRRSDAYFLGLYRDFSAGKQKPLNLFVDEISAMLDDDPRNFPYPFELPSHMMRKPSGGKLVQSSAPEALCASTVTQMGASDSVGKTYNLNIRRVMQLPYKIDGSMDVCQWNIFALESLLLLHKHLSSFLTHPCLSNDYNGTIKDFLLKNLGIIEHLVTRIRNFIEVFRNRINISRQHFAVLDLVLTPRDSFVNTSPHIRIHPMDVRYRILLLIDSLYKNDVPLSNGILFDLTDFHNFIHRQLCVLKLSFSQKLARVIRRIPVLDGDLDSRWRGALESEDPKAILDLKFTFKGSANVERVTNEILLLLCECIGTLNSLRRVLLQGKWGRKTVRDSDCTSTYAKLIQLIKRTVQLEDLDNTLMGLLRMSENSQFASTLNKSCSTCALKSVNAPQKQAICKRCLESTLAERRNSLRFSCGRRDTPKELKIPISEADEYFCTPMSVFNDEDISVLKRVSGRRGCFNMCISRRNSRHVDMNDAVINPYFLCPMETVKLSRTWKLDDWIVLRIASCYHHCFADNLAFSDWSTNFTTIEYVVYFISTGSLLNFLLFKEPHNEGYTDICTLFNALLSVGSMHTRRNEAPYYPSANTCFARGTSGAVRVDNGGSIERDLYQDIFTLLQVPHNVAVLPKVLGDIDLYLTIDMREAASCFKKMHNVNGVPTYSSLQHSDLLSRENLNDRLSATKVQIAGMQLNRAGYKVYRLVLDSICYNIPMMTALRRSDSMSLINSSPCEQLVTNVLVLRVLTKNFRRTVLEQLMHFNPEEGVNALSYKLSTFVLINRLLFRNELEMNVKGEEGPLDSQSLLEVNESGLSMDFILRRVVVEQAKNAVITSLTGLDAFKIDDIDTLGATCIDNIVTSIKEHLMFAAVWDEFLPNGDFATLFTNACIHFIKVEINKRTNRPLDVCKVMPSAQKLRLLQREVETSRLVKTNGNTQQNDLLKVLQFSFQDTGAVGRDLLAEHCDIMEIIGMSELNKRLSTFKDIVTRGMKNEDWTRLGSQYHTCAVVDMATVLNATLNATLSLRVPLENLLVPLTSSLENVLNHYFITVAGAKVAETIDQAFSSLRSESGLAVEVLKKLGNVGDIDKTLLQMSNMLYLGNYLTNCQDNILQYYHGMLTERCDGSDEVHRKLSTDVYRDSSKFFSFDFDSFLAMKELALVPASKRLIQRQCEHHLQTLARLCSLKMLHPISTQLYQPTVVQGNRFPQFLDLIEGLCFNFCKLGSTCGPALLAVFEVSFHCLMSAFQRTRCLRQELPLLRNDLRSLELTAQKHHQDVSDLVIAASELIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3V7</accession>
    <name>A0A061D3V7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766928.1">
        <property type="nucleotide sequence ID" value="XM_012911474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3V7"/>
    <dbReference type="GeneID" id="24563283"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110400"/>
    <dbReference type="OMA" id="CNVGVMA"/>
    <dbReference type="OrthoDB" id="366401at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="326" mass="35201" checksum="ACA2336F1902CD24" modified="2014-09-03" version="1">MAADHHRANYSTSSGDNTRPPKRKSRFDSPSPFSSAAPVPPAPKASNFSTQPPHAGRYHEAPPVANSSFPSRPGFPAHGAYPEYRRSDDRVPPPPPWPYPDNVVAASQARQRAAPTSAEPAPATPPSALETCNVGVLASLLRMQRDSGAAGFGPYSALPADTVVPQYTPPDAIYDSASTRVSDFYDELEELFECFGARVSPDDPSYDYSRRKQLSASRYRSIPMTLVADQEALRQWAGVPYESAVAYAGRSGGFSNCAPAPSRTFHPPTDSSVATGPVGAVPSGLLSAEMPPDPNALESFRRKRANEYHEQMSIKYARVKVDHGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3W2</accession>
    <name>A0A061D3W2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">26S proteasome AAA-ATPase subunit RPT4a, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0204160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767444.1">
        <property type="nucleotide sequence ID" value="XM_012911990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3W2"/>
    <dbReference type="STRING" id="5866.A0A061D3W2"/>
    <dbReference type="GeneID" id="24563799"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204160"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="181"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="404" mass="45396" checksum="1DA8898C1B276C0A" modified="2014-09-03" version="1">MASESVNPEPDGENREVIRQFVKKVREHRDIDNRLKKLRADIKALGIKDDQTEDDLKALQSIGQIVGHVLRAIDHGKFLVKASSGPRYVVYCKTKIDPSTLVPGSRVALDMTTLTIMRKLPREVNPVVFNMLNESLSTKEEKQTLGYHSIGGLDKQIREMRESIELPLRNPFLFKRVGVKPPKGVLLYGPPGTGKTLMAKALAASMDCHFLKVVASAVVDKYIGESARIIREMFGYAKDHQPCIIFMDEIDAIGGKRFSQGTSADREIQRTLMELLTHLDGFDDLGQVKIIMATNRPDVLDPALMRPGRIDRKIEIPLPNESSRVDILKIHSSKLNKKGNIDYVAICRLCDGFNGADMRNICTEAGIFAIRAMRDYVVEEDFFKAARKLTETKKLEGTLNYEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D420</accession>
    <name>A0A061D420_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0204560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767484.1">
        <property type="nucleotide sequence ID" value="XM_012912030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D420"/>
    <dbReference type="GeneID" id="24563839"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204560"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="562" mass="62469" checksum="1D29F7C51AD1419C" modified="2014-09-03" version="1">MSEPQITSSADPAVAHVEDEKKVEKQTEDYGTFGQVLYHLVSFTEGYEQQVLYLCMRLFESTMGFTKQQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSSTSRYSSILFLRFLHGAAFGCIYPVQQKIISDRDDDDDRNSSSSTFTRLHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYVWISIGIAIIFVMTTPKELISPYNSMMGVIQQISGAFSAVFTNWSAFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDLKVGIAIVVTTIGGAAGTAAGGIVIENITSMHKDYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIEDKYQASASAIIQCISGISISISFVEIFAYVSEKLHGYAPSTQAIDDMDAALKDNNTEALRKSTMYMIVIGSLLNIACYGALFATYKEDKKVVEQKNVVEWKEREERHEARQFRKQTLDEIPIDKLPDEPESKSRVVEVEVKDPEEEMKDILDRAGDRDSDEIVAPEDLTAFLRSERPSWHQGGFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D444</accession>
    <name>A0A061D444_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765935.1">
        <property type="nucleotide sequence ID" value="XM_012910481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562290"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100780"/>
    <dbReference type="OMA" id="YENECEE"/>
    <dbReference type="OrthoDB" id="360979at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1401" mass="158083" checksum="6F4B12F1CC93F0EA" modified="2014-09-03" version="1">MKKRSGSTRGIEYTPLWTPIDPSGLIRACCDFIEGDTHSQLILNNDPSTSLRVTSKHARLRGSHVDIVSTGERLRFSRASTRVCQKLVASELSAANGNRRGARGPIRPITGDAEADEKTMQTSNLEGDSVGVEEDVDALDGAGNHRRSAGGSRSRSRLQRSHGDDGDEILPGGAQDPYAPAPDVDRLLDDMVTNLKRLPLVRNECEQCARQCKLGEAADSSQQAVNVSVPCAHALGLRHAPNVQGFHGSARGPADDYMDIDASCGDPYVTGAKNRRLARLTTSAPRDANDDADPPTSDDDVEHLLTYRQETVVGDAYNLEDASEKDVSKLMEGTKVVTPLLDSLDMSLLRNVNARLRPRNGDQVDPASLLNDLTDMRGGKGGGDFNRDGLVALTGTVVDPHAYKQALWNCPEEYRVEGIQSSASPIITVRSNRQDLSDDLAFYTSDTLRSSADEVDTAHSEEPGLRAGLYAQERDSDVYYDSDMSLAELMAKYLVLRKRSDCEVSVLKTLKHLICKRLNKERLYLWHRSGSKSSDTPSEMYGSNVMMQTLHRILQTLDVTSSAIPEALEDAASTTGRKDDGRDTSVYTYSSISVSSYRSISESMFLPVNDREVEQSWILDLHKNLVEIYGVLTVEDENRSDLLPNDSDDLYCELIGDTLSMYPLREVTVTSADLFESKPIIVIRVDDSFTCTPVTATKSGTYATRINTRLYRAKSRRPSEDDEGLFLTLSSSQYDMMRWFVALSTRPKVTSFLYLLENQRQMRVYNSNLYFILYPNCREIDFSYFMFDAELERQIVKSYVRLPIRRLILANRSLSDADLPQLLSIWNYDIDTLELSHNSLELRECGTQFVSFLKKAHVRRVFLDGNPISAQGIEALAAAFTNSHLRHLSLRGCALDDCIVPMLRRTNEAMSIRDRLTLDAREVTTSETTHHFLKTYPLKRVKIGTVDQHMAYPETDVEVFMDCHNLDQINKLGILFSGKLLAAKSTGTKFRFCGLCKPRSVSYTFGNDYCFFEFRPPYLIIREPDSNAANNARRSNSQTRPSMYFLAGCDIVLMNNLRWLQLKLNTPKGVTLWRKCEFNLDIDDNTNDDINRKEDRRILVRAYTDASTRRWFELLNRHMSGVYYVRYVRKHPKVSLSRHILSFCRRPDASHLVLYDLPYDRTLWASFFRGINSMSCLRVLDFSNKKLTAENMDYPELLYGDLKLDRLDFSFNRLDLRKAERTVFNGILPPLTVAVYNVSYNPLGDCDLSADLFVSACVRANAVKLCFNYCSLGDRFLDSVVKLLENIRVPDEDSRLEVVELEGNRFSSHCLQAFVEQMLLSLPSMDVIRLHGSVTANELPDSIFNDKDLMTLERFSPTEPRFGSFIRKTYLRKPKRTTRESVARLVKERMASGDAATAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4D4</accession>
    <name>A0A061D4D4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767098.1">
        <property type="nucleotide sequence ID" value="XM_012911644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4D4"/>
    <dbReference type="GeneID" id="24563453"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200690"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="88" mass="10110" checksum="29D61E6ABA398553" modified="2014-09-03" version="1">MNQGTIMFNSIDNCAVELPQKRIDGWLRPTDVPNTHATEPLGALMKCGKRMPVTVKWIKTPSAWAYNREPKPSFTSLRHFDAKRRNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4E0</accession>
    <name>A0A061D4E0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome biogenesis protein BMS1/TSR1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0206060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767634.1">
        <property type="nucleotide sequence ID" value="XM_012912180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4E0"/>
    <dbReference type="STRING" id="5866.A0A061D4E0"/>
    <dbReference type="GeneID" id="24563989"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206060"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="3">
        <location>
            <begin position="221"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="4">
        <location>
            <begin position="420"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="80952" checksum="893337EA10B51ACA" modified="2014-09-03" version="1">MAVHRAVLKQKHKPFKNGKGNGVKPKRPSAAVGKDVSLHRRDKKSRIVAKTKNLRSAIQDEAPRLVFVLPFHESANAHEFIYSAVCQVSVESASYVRSSPDGWTVSPPVLLPASMLRDGLPRRVVLFSCPRSLSAILYAASVADVLVCLFRGSTNDDPAYDDFGYKALSVIRQQGVPPPVGVDLEIGLPGDRSGSCTLVRRYFFDELGSDKKFVSIKNTGDFVAAITAIGCVSLTGLTWRAGRSYLMSLDHSYDASTRQLSIVGYARGLGFSVRHPVHVTGIGDFLVQRVELLSDPCPVKRSSAMESETVVEELSDEIARELAQEVECLSTTVARPSDMADGDDLLEDFEKCVRVGGVSDEDVDMHDASGDGDGGEDSGGEDSGGEDIDTYFSNLEDLNPSQKRIEFEKRALEDLSFPDEVDTPVDVPARERFRKYRALRSIKEGAWDPYESLPSEYLQICEFENFRTTMAHSRKTVEVNCSRTKTSGRFIRLTLCNVPADCHERMTTTAGLSSGKTAKPLILSAVFPFERKVSVLSMSVTRSFEGPDSIASKRDVLLYCGFRRFPARPIYSEDVAAEHGRFGTFCRFVHKGHTVVASIYGMALLPNTPVVSLDAADPSVMLYGGVVSGADPTRIVLKRIVLTGYPFRVHKRTAVVRYMFFEPRDVRYFRPAGLHTKRGLRGVIKEPLGTHGYMKCMFNDVIRQDDIVCLALFKRVYPKWHPPSWSVWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4H9</accession>
    <name>A0A061D4H9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear movement domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767669.1">
        <property type="nucleotide sequence ID" value="XM_012912215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4H9"/>
    <dbReference type="STRING" id="5866.A0A061D4H9"/>
    <dbReference type="GeneID" id="24564024"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206410"/>
    <dbReference type="OMA" id="RDVECSL"/>
    <dbReference type="OrthoDB" id="515366at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF18">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="148" mass="16701" checksum="5A996F3DE0456241" modified="2014-09-03" version="1">MDSALNVAVNGSNEYRWEQSFDGVVVYVDLPAGLRKADVTVNFSPRELSIRLGKDAELKGKLCKNVDTTESTWLIGDGKLEVHLTKAIKGEVWTYIFEGDRCLDELNAEGDKKRLLLERFQNEHPGFDFSGAEFNGMVPEPRTFMKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4I2</accession>
    <name>A0A061D4I2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ C terminal region domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0101730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766030.1">
        <property type="nucleotide sequence ID" value="XM_012910576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4I2"/>
    <dbReference type="STRING" id="5866.A0A061D4I2"/>
    <dbReference type="GeneID" id="24562385"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101730"/>
    <dbReference type="OMA" id="MATDYYA"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000064">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="206"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="468" mass="51245" checksum="8D686A5462B4AE45" modified="2014-09-03" version="1">MAIFRVLTPQKRGSARGFYTCLAHIATRSAAYVRDALVTGGSFGEHRTSCAARASAPSSRHTRGLHTSAFRRNKDPYSVLGVSRNASTDEIKRKFRELAKKYHPDLNPSPDAKQKMAEISSAYELLSDPQKRKIYDQTGMNSSDGGYDPSAGFSGFGDSSFMFTDFAEMFSRMAGAHGAGNAFTGSTRGDDIQTEISITFMEAVKGCSKNINIPARVACGDCKGLGRQPGTSIEVCKICNGTGKRRRHGFDLFVTGVQRMERGPIIIGVPCRTCSGTGQVIAHPCRACGGTGDRAQTKSVNVTIPAGVRQGMQMRIPNQGHVGMRGGKSGHLFVNINIQPHHIFKWIDDDIHVHLPISLKQCLLGGNVVVPTLDGYTDLTIAPNCQPFFIKTLKNKGPPKVDSRNNGNLVVHLELRLPDTLTARQKELVEEFEKETSSDPRSSRNTNENAHEEDKTRWWKRVVGAKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4M8</accession>
    <name>A0A061D4M8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767714.1">
        <property type="nucleotide sequence ID" value="XM_012912260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4M8"/>
    <dbReference type="STRING" id="5866.A0A061D4M8"/>
    <dbReference type="GeneID" id="24564069"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206860"/>
    <dbReference type="OMA" id="EFIVQYF"/>
    <dbReference type="OrthoDB" id="364814at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF3">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68619" checksum="550C45D798C459C4" modified="2014-09-03" version="1">MAPTEGDATADSRPGRFVRSRKRFKAYTWKYKKTISPIASFVLVVNQMIGYGMSDIPCVMREGGWLYALLANILVAVLAAVCSLMLLRAMTLIPHNDNFDHRIEYNTLVKYYLSDHNFRMVALLHHAGDLCSVVCGILAFSKLVDMLLVRIFGWTLALQVYPHASFGRVDMRTVTAIYESSVNSGTDGPTFTLAITLGYVLCAALCLRLSACALEETMGFHVFSFLALIGCTMQLALFGFARYLGGVRAAKPPAIGGTRFSKVILTFVENFNVASSTPSWANEMTSDVKVVRTMWTSTFFTSAMYHVLGYILCVGFPANSGSIVSDILLSNTSLLTHAAICLFVAVNVLPDVVFGTISTKYNLLNLGYCGSKSAYFWGCVLPFTFTWMLSNESIFFEYLGHIGLISALFCDFVIPVVVYKVANDSMADFMDAAAGYEGRMNADGSYYLGDGSNGVDTFLKRGTSILFNKIGSISRAFTMDMRQKPIAEDLLKSDSLRPEAFHNIARQQSEMDFGGLDFAKFRIIRPPLMPRPDDHLYNVIVPQRRPGRVMFEGLGLCDPDLDDDETLSTPPQSDRAASKQRVEVFPVQFLERHSTMVTHLILSLLAGMMVMPMVSRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4R7</accession>
    <name>A0A061D4R7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0102710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766130.1">
        <property type="nucleotide sequence ID" value="XM_012910676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4R7"/>
    <dbReference type="STRING" id="5866.A0A061D4R7"/>
    <dbReference type="GeneID" id="24562485"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102710"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600605" description="Sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="275"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR93944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="383" mass="43749" checksum="3C275A5B77692923" modified="2014-09-03" version="1">MYLRLCLAFVFVLIAPPSFCRHASTDFSLSEQERESLLTRLSELVSQSTQALESLKEAAKRSREEIDKYKYLIPNSKDSKPVEGVHLGELKQGKTGGHPSHRGFTQVKSSEPASPEFIRNALYATQPVSGTPQATVSVDALENPNDVVKNATEVATFSDDGSRDFFEEELYRMKREIHSVNRLHSLKNNANVLSTEIRRLMTYKPDSSTQAHSKEAQRYEICVNIQSCTELLNTVNLWIFLMAKTVEDAYKRCEDAACRDGSEGDSRNDRSNVKMPPNRKELGRAGWMYLHSMAADFPDEPSSLESLRVKAWCYSFAELYPCHICKEGLVEIYRRLPPVTDSRRDLLLWTHNLHNQVNADLSYPHYNGTYEELLQLDRHEKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D513</accession>
    <name>A0A061D513_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766240.1">
        <property type="nucleotide sequence ID" value="XM_012910786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D513"/>
    <dbReference type="GeneID" id="24562595"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103680"/>
    <dbReference type="OrthoDB" id="10513619at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="98" mass="10797" checksum="11A6390BD67F56D8" modified="2014-09-03" version="1">MTTSDPHAVFHLLELDLPAGDRGTKRYLYGGVAVKGCVPRLVRLRNIHDYESEVFQASAQVVYGRGGHTHSDSVRIALPMTAAAVTIDNDQINPRWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D581</accession>
    <name>A0A061D581_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0104380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766315.1">
        <property type="nucleotide sequence ID" value="XM_012910861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D581"/>
    <dbReference type="STRING" id="5866.A0A061D581"/>
    <dbReference type="GeneID" id="24562670"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104380"/>
    <dbReference type="OMA" id="DRPKPEW"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="180"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="298" mass="33632" checksum="66C7503C1C813A83" modified="2014-09-03" version="1">MDMCDNAAALSERYLAGEGFQVPSPKNIDTTLQLPLTLVRRVPVSPTAAVFVLQYPLEFEEAFRSHVFAHYLFHGSHFEPSVKGCWNGKEAPVEEGNHVTRKYTPVFVDVDRREVHFLIRIYRCCPEYSDGGRLTRWLESVEPQGTILLNPWFTKYALGENGLIGLANGDPVEYKTLNIVAGGTGITPFVRFLIHNKEARVKLLYCNKTLQEILLKPLLDQLRRRGNLEVRYLVTSEEAAVVDSFIPTEEDDIVFGKLSRKYIEGFFESEDSVTVSCGPPGMVMTVKKITSELGLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5C3</accession>
    <name>A0A061D5C3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768082.1">
        <property type="nucleotide sequence ID" value="XM_012912628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5C3"/>
    <dbReference type="GeneID" id="24564437"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210490"/>
    <dbReference type="OMA" id="ECVYLVF"/>
    <dbReference type="OrthoDB" id="366128at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021366">
        <property type="entry name" value="DUF2981"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11200">
        <property type="entry name" value="DUF2981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45003" checksum="110E0FB427CB88DB" modified="2014-09-03" version="1">MVDVGINIANNLKAKNFMGTLSIRNGLFFIAIQQFLLGVSLYSVIHYLHPSLTKLAWLLFGVNAISAVLGFLGALKRSMVIECVYLVFYFISLTLVFLTVLDMAELVHLLPKAPQIRDVSDFGALRSAAFLRAGGMKPHVFLRQRDMPLDLGEDDFSTQGDDDLEINPDDDSKLRNDGHNALPTDVDIAPLRSPDLDRQQEISPAKQQRQHVVDESGRSDVATPAAVATNNAEGATVDSDLRDLEANRNATTTTAPKRGRDNANVHVPKALAAPTKENEVTADSLPAQAEVADSVEPAKEPNAEDAKMESFYDRLPLVPHLGETEGEAEEVSKEELPPETHDLTPEGISEVVAIYKIQKRPLKMAAAGLTTMALLFNIYCYWVAVTFVLNKCTCLDELVSHPEQFTPLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Q5</accession>
    <name>A0A061D5Q5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Karyopherin beta, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0210360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768069.1">
        <property type="nucleotide sequence ID" value="XM_012912615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Q5"/>
    <dbReference type="STRING" id="5866.A0A061D5Q5"/>
    <dbReference type="GeneID" id="24564424"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210360"/>
    <dbReference type="OMA" id="PKRFVQE"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="11">
        <location>
            <begin position="108"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="458"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="10">
        <location>
            <begin position="473"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123167" checksum="A568C74D7419AC07" modified="2014-09-03" version="1">MAMNLDEEVFRSLLEALTSTNSAARNDADAKIMALKMTDINTALKLTLNVLLTDPNEDHRLQAVVLLRLLLDLSKSGDAPRNMWKAVSPEAKALLKQSLLRCLEVETQNSIRSNACDTIADLCDACLAPDEWPELTRCTIQLIQEENPLYKKSGFKLLGECFTYFADELSPHLSNVVQLTKNSLMDANASVRTETICAISNVLEDDVLDIASQLGDATPYIIGHIKQLAVSTDNASRVELERSMAGLIMIVDNNAKILKPHLQLFFNSMMEIATTESAQPNLDQEIRCMAIEALVTLPEKKPQMALTIPNFGLRMVVCLMNAMLDIEDDSYAEWLETGDTDDDVQRLYDAGEEGLDRLGRAFEDLDDSPFMDWVLSNASQFIQQPSWQHVFVGIMAISQTVEYLTEDEVEEHMPSIIKIMIEKLKDQDYRVRFAACQTIGQIALDHQPYVQMTFFEEIIPALLSTFEDQSPRVQSHALSAFINYAEEVQKENLLPLADVIVKQLLVKITPAAHKSVREQAITSMAVVAGVLEEHFFKYYSTIMPLMKETIATCVGPDDRTCRGKAIECISIIGMSIGRDVFLQDGIECMNALIQIMQEPTTPDDPVKEYIDEALGRLCTALGPNFCPFLPTIVPLILRSLEGNIKSFNDEGDDMTLNMGAEGAAGLRTTLVEELERSLNLIANIVEELKEGYDDYVVPTAQALMPILGYVLTSELKQKALYAMAQIINAKKLALEKNGGSKDAFMEIVLNTLNNVISALEKARDNESQLSMPVEILTANADGLYKCLDSAGPGILNVNILNVVGQKLLELIEESSRFKKAYSKYKMNKDLDPDDIMSLEIDEENEQAYRSALLELFGVIMKHHPDEFMQTCHNACLQFVMAHLAKSQADDIAVGLYLCDNMIEHLKSRIVPVWPQFLGYIFKYVESKNANVRQSACYGVSLLARMPEFAGMENEAAAKIAASLRMTFSSTSSSKREQQAATDNAVAALGEIIKFHGANLNDAAAYLNMWLKHLPLKADEEEGKRVHQGLMDLIIANDPSILGPDNCNMGQLAKIFITIYETDSSTEQLNSQIIQLMKHLGDGFLQQLAPSLPKKLQMQLKTIRRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5V3</accession>
    <name>A0A061D5V3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0210875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768124.1">
        <property type="nucleotide sequence ID" value="XM_012912670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5V3"/>
    <dbReference type="STRING" id="5866.A0A061D5V3"/>
    <dbReference type="GeneID" id="24564479"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210875"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210875"/>
    <dbReference type="OMA" id="FRYFWTH"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600078" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="107"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="284" mass="32515" checksum="2F6F5C57EE075D39" modified="2014-09-03" version="1">MRHVCVNLPLQAGLLWLLLAALGSCQEAAAPEVGQPVPEKPVPTKLPPPHFEEPIAHDEPFDEVPRSSDSLDRSDYEMDDDDDDDDFADSFYEEWHEKMENFHPSAMLSMDIAPKAIEIFYENVRNTGTLLRGMFYTLSKMEELKVRVTIKSPSGDVMYTKEAPDGIYSFEAKVTGVYEFEFHNPHWLTAVGVTISAGSDEHSVLESKHIKNTQSRLDQLKNNVDSIYAQFKYLWLHNHRQMRASRDTQFRLLLYSLVQFMVVTVCSAICVTYVKKIVSHKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D619</accession>
    <name>A0A061D619_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767648.1">
        <property type="nucleotide sequence ID" value="XM_012912194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D619"/>
    <dbReference type="GeneID" id="24564003"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206200"/>
    <dbReference type="OrthoDB" id="366342at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600635" evidence="1">
        <location>
            <begin position="21"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="329" mass="36713" checksum="820F4249C83267AC" modified="2014-09-03" version="1">MKFFIPLALYVASLINVTAASDDEQIPPPPPPPELTGDITQKIDGVDYDYVIPSTEKRFKVVMSLMDGDGLNVHLLEKVEEVFKELISHSMHKWTEALPTEHQDRFLRYASQQATSLPTGIQMQNYTSVEQAKAIRNALDISGKSFHLLFGLLFGDYAKHVSHESTKAEATQIEEPGSDPNVARGVLDAPNNSHNVKEGMQIDDMFLNLRFVLPSFANDLYELHGVIANKPNETNLDKNAITRSVMDWMKIHLPEIEANKVVKGYEIQQKLTQLVQNEPHLTEAIIAFKAYNLADEDLKSSVAKCKEMNAASFGTIGLLLAAVFASTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6H9</accession>
    <name>A0A061D6H9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767808.1">
        <property type="nucleotide sequence ID" value="XM_012912354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6H9"/>
    <dbReference type="STRING" id="5866.A0A061D6H9"/>
    <dbReference type="GeneID" id="24564163"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207770"/>
    <dbReference type="OMA" id="FNCLARS"/>
    <dbReference type="OrthoDB" id="10253982at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="149"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="615" mass="68656" checksum="AA15B3C5DBC53265" modified="2014-09-03" version="1">MATRSHDMAHGSLGMVGRGAADVSDLVPLANTGIGCGMNADAAALQQSVVFNKPSDMVEGNVNAAEECRADGSRTITKATVCMPAVEPLDLLSIKLDSMRIGVPRASRNGQPESDTESLVERNWSSGMSKAPPQGTASRFSFEPLKVMSFNCLARSLVDNKYVNNDSEVMSWNSRKFAILDVVRDSLADVVCLQEVDEAEYENFFSGEFQRLGYRSVFKKKKSPKLDGVCILYQEERFEVLSHKDIEFAVDDANYDRLQVAIVLALVDKRSKLVDDEQAKVKDIYIFSNTHLLFNKNRGDIKFAQLCALLLAIKDMESVCMEHLGAAACNHPKPAIIMCGDFNFTPQSLLYHFLSKGYVVLRNCNVRLISGQYLMFDTMYKTEQGGHGKSGITVGNFEGNYISDIYGTGTEGEWVEPLSRTTGIDMFTKMPEWIKFDEGMHGVISKYLGAVNERSLSGKEDESSVTPRSKDADDVDKTLGGEARDLLFCPFKFHSAYSTFDPGQNQCNEPAFTAFHGWQRGCVDYIWYTADELNVQSLYEMPAYRDVKANGNLPNKGWPSSDHFSLLSEFKRRSMVPLVWIVDVRQGEDVVVDFLEWPSPVFDHPADEQDDEECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6V7</accession>
    <name>A0A061D6V7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768454.1">
        <property type="nucleotide sequence ID" value="XM_012913000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6V7"/>
    <dbReference type="GeneID" id="24564809"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301720"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="8016" checksum="01E35EC0750CF74A" modified="2014-09-03" version="1">MTAVTPSYRETVEICDTPSGFLRNAIANVPIAIINQDILQGHIDTHVKWEDLMEMDFNCRTFQFVVLCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6X2</accession>
    <name>A0A061D6X2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DnaJ domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767933.1">
        <property type="nucleotide sequence ID" value="XM_012912479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6X2"/>
    <dbReference type="STRING" id="5866.A0A061D6X2"/>
    <dbReference type="GeneID" id="24564288"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209010"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55811" checksum="58C5E650F4CDD0A4" modified="2014-09-03" version="1">MEDYFAEFSDARRSKDPLCYVGNAAAWRNADAESKSPCSRCEPEWTAVKQADLSSVYGHLGQNDSTPYVEERGSEVHEHANVFAAQDASSDSLNELLRNLGIAATLTAGRAGTKDDHCSDATSIPVKRVQSVNLEGSVDFFREWGDDATRFRDVDPFKSVDASERERSAASSDCSGMTTDLVGDPNQKGAYCATEWDNGWSVDTVEVASGQSKPARDSNQDECHQGASVRAGNQPQDLFGDVWLSSIGNNGPNTHEINASSNGPCGAGGSVLYTPGEFQHDYDRKMHANAPRRPGSDDKQLLFSESLDEIDRIMSQPSTDRSKNRAKQELWDTWFDELTPLSRDGGVTVPEEPGDDVVSPDGGVDEFDSLMDESFPAWASVREAHKSDANTVAGDGGIDAGTGPMSSEHTDREELLIRREVDEWAYTGTGELKDIRTLLFTLKQVLWSGITWKAMDVTSCVSDKAAIKRHYRQALLACHPDKHTKSDWRTALRAQLITQALQDAWATLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D784</accession>
    <name>A0A061D784_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768762.1">
        <property type="nucleotide sequence ID" value="XM_012913308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565117"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304790"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1715" mass="191662" checksum="FF5588A27777100F" modified="2014-09-03" version="1">MAPHFKKLTDCPENLREAIDWLIQVRRGNGENGEGLDQLVKALKKLVDEAIEKAYTTNVDALLKLLNSAKSYNCCKEKVAKIEELKDPKLSTDESLNTVLQHVKDLNDCSKNHLESSQQKSYEDIQSRLDHLKNLNESLNGFTNVDSCKQLLTNLCSGLETFLGFDPKSKGYTGEGIVYSDLDRLCDGVMGFFHGVLNAVKDDPSVTTYYNKMETTLKKIKESMYTPDGLSKAAEAVSQALGEWDVELRSRAKNVSDAFKTLITHRFDAFSGALQNLKAIAYDDQFQHIGAKLSNCIGTAGEMSKAFDAAKLAYSNLDHELRRKLQGAIGRAEVQVRAFIVAASNDELKAVVECSEYQLKELGDEIHTKAELLVGQMSTNINTHFEANIKKPLNDVNEKLSMVHRDLGKWVEAAEKFIKIIEQQVTAIIKEVGLVKGKPHEISGAAKVISMKAGELHTKFEELKKNYDEVITTIKGKKGDGDEKECVMYLLNNATTKVTAPTNIAPYRQKNGGWALSAQIEGLIEKMKKNAQEFVGTLAESLSEGVEQALGTGQTPGLDALKRSKLGLMKEIGKWIQQATGEFADSILGADLERFLTNLRVAREGWKGKPPAASASSMYDKILQGCKEEIGNTVTDIDTELLALLQAAATSGATNLHNEVKIIVNDKLKNIKNEASELLKAAKSAESIIIESAGVVENNLKQLCKKIEELAGNGLEDRGLKQKLVSLKEIVMNTLHSEASYSLNGILTRIKGIINSNTEGNLQAIVSHVEAFKTAIIDKEVQDFNSNIQALVSNKVSDATKEIQKKAKDQYHTKISTMFNTMKTKVEYNILEINDIIEDDSESGVKGLLRKLYDKQGGRLASLKHPKERQIKSAFAEMSKKIQDYLDRILLYTEDQVMTPPPPKLRVQKTPTEQSEQVKLIKGNLDILLDVLQKSDHFDHQFSYNYQKLDTTLSALHPKKYTTKDSPVLLDTLAKGMSGLTRELQKVYISTYSGSFKYFVWDPELGNKCAKICLTLISIIYDGLSRLRKECESKSGSKWNHKPINLGKDNGLGAFLGGCGFIVSSGTDDQNGELRNEKGCRGEQISDVLFKYNLVSEFDEDDTNRDNYSTLKICLDYLHDYYQVRHLSSLESLKHPSTIYEMLCWLSGLPHNLTYKDLKTYVKNIFQVSDKRHPFIGAYPHPLSSKNILDLLKHSCSESHAIIVAILGNGHVGGIYACDFYTNESGLLYPTDMNSLICMLHDILNRLYFQLYFLYQQCEYDTSLSGWLDCEYGRGVGGSGWRCNVDQCANQACNQKGGQRANQNDYQKADQRCQEHPKCGVKSPLQSFLEDGLQGFLPHHLKSERGKLECSLKSHSGLPCITPMGFSGISQMASHRDTGQRILDALGGYCGHQSSPLTKLCSRFNCLLPSVPKTLGDLLAFYHQFLINWSGEHKKTAFNDCVTSANLGREYGAMNECAMLFESTDHSTSHNLGDFNSLLTVDNACYVSNGKCGAYLDSLSYEICGTFSKRNAALYLSWMVYLTETLYDLFYKLLKECEKNCGSGESKCQITGCDKNYCFAFKPQIGQEIGQMHTQLCNSMLSCSMTFPTLYSFGLVFGGRRQLSGRNHNNYIIKRSCKDLVQQLQIVLNERSILSKILHDTIPNFLWTIRQPFSYLILTWWSLSLLYLFYVLLGRLDTLHIKSHLRSPSSHRIAAQSLLAAARVNKLAKITYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D794</accession>
    <name>A0A061D794_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mRNA 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.6.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0209900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="7"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768023.1">
        <property type="nucleotide sequence ID" value="XM_012912569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D794"/>
    <dbReference type="GeneID" id="24564378"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209900"/>
    <dbReference type="OMA" id="NSCTINR"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="9">
        <location>
            <begin position="52"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="9">
        <location>
            <begin position="194"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="415" mass="45682" checksum="084C9892F948D572" modified="2014-09-03" version="1">MVAECTSTIAGSSAVDSDVIASRLAERLDSLSLDGPLADALQNGDFDATSGAARCELEIEVRLGSIKNTYDGQRFTLPLETDALLSERASVRFQSSVSSGQFQAASGFLKQVAEISDDRLDWQTQMGVLTFDRFFKLPEYEESVRISVPQNQTTARAKTFEAIRKVKLLTWNVSTGSASRESQMGDDSGETGDQDHLDYRVAVNLEYRVPVRELPSTSSATTRRKKSRNTFIHSEGHVRFDLTQVQTVSNDSGAGDDGPCQYEVEAELLGSVVLDVLKREATPQSERLQLLKYHCSTLVNAIKHLRDVIMRGDTYSDPGTAMVGGIMSTKLGLCDLRVVQQGNAEVSKYRKEVSPQLPLIGDYLFRAVTPALERGLVKRQKASPYREHLAEIPGPFVILDGGPEEGKRVVLSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D799</accession>
    <name>A0A061D799_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0303170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768599.1">
        <property type="nucleotide sequence ID" value="XM_012913145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D799"/>
    <dbReference type="GeneID" id="24564954"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303170"/>
    <dbReference type="OrthoDB" id="366136at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="220" mass="24982" checksum="DBDDCF339FF4A090" modified="2014-09-03" version="1">MIGRFRGIPVTIDGRKGRVDTEGSATEIRALIRNTRAPKCVDEEKAGARRGNARERSGHRSRGSARERHDSDRRRVNPEKTAKTDVYNAIGERQNTDAQEAALRPGPAQHAADTTAMLQHALGERTDINVAALSNEFKELNYSKAYGIDITGFVGMQPEILNVNVPTEAKPVSRQQRRQFRKEEIRNHPDRFWKCNKCEFMNYLSNYQCDGCQQLRNANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Q6</accession>
    <name>A0A061D7Q6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_C14 domain containg protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767120.1">
        <property type="nucleotide sequence ID" value="XM_012911666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Q6"/>
    <dbReference type="STRING" id="5866.A0A061D7Q6"/>
    <dbReference type="GeneID" id="24563475"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200910"/>
    <dbReference type="OMA" id="RYIKGAM"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="438"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1151" mass="125859" checksum="C4BBF765A48C52B1" modified="2014-09-03" version="1">MHSVPVKNSPPPDLASAALAAHQDVVQVLKTTKFVNVANLNEYLSSASGPNCRVVVQPVEAGSAIAEQLDRALEELQQRKAVSASPGSTTPGCSNGQHANTPVNTPAATPSHLPQPASTSAVASVQTLRQAHSEELTRPATFMQQQYRAAEVRSAENLTSVASSHRCVVSSSTSQSEAAQDPNSDLKGRVSSLLMQLKSVNLVPSTPEARSEADGAQRTTVDSYSSFSDFNVKNAGAHNDGETTKANSEEPVMRIETKPNPAVLVLKSPVAAQPVAEEESKSPSQGCREACQETNTLSSTLLCQNSATCTYRENPNVESTLGPQQRDCAQRPVQQQGPAEDPMSALAASMQKQAAVRASGDVFNEEKSESRVVRRFNVPVRNAPAKPVEEPRDNMLRGLNVQAPTSNMKPQRSVDSSMQYMPRQRTQRVNHVRKVGPRRKAVVVGCSYYGDPEACLRGPCNDAMLFASTLVTHMGYDPDDVLLLIDTEPADIYTRQLVAMSSRPNPSLSSRRNSMERRKTGVIGGLLGGLIEDVFKGVVADSDLDVPEMLMLDSPGAAIDESNRPSRANILKALRWLVSGTRPGDCGVFYFSGHSVQTDDMSGWEGEGYDEAIVPCDYMSFGDPSRGVIPAAQLRQVIQSVDKRCQMTIVLDTVGMQTALDPAGRSGPWRYIKGAMLRGIWPLTDATGKMQRACYDADVWRDVHMQQQLVRPKFLPMLQVDCAAALLDGFISSNTGAVSSNSLCLAAAPFQDVAVEALFRPVSLSGMPLAPSIYQGCEQVVCHGVFTYCLVATLLKDRASKRGGITVREIISGIQRRCKYLRSTRLPKLSQACEATVHPAGVASVDDFFLSPWGGRVLIDRHRNIAVEHPLKALSAGLGAFLTLPEAWMQLHNEGRMRAVEQREKFGRMRSAVVNGSRMVTEDLRQMLLQQQQAQHGYVSRVPSNTVMLGHVPQQQRVDAGNSWYGKVSAAQSPQQRRSPEFDPRHALYQPQCQQQRQQMHVLQQHNHYEPQYQQYVVHPSFNMAGHAQRCAGAAANMPLGMTFPGAYHAQQYQESEEYFEASPPQFGACQQAPTAPFMHFVAPQAAQKHEPRRRSYHCRSSTSTMPDMGCQSRPAVVRHNTGSCHRGNIKLAEHLTSSFVAQLPTAQHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Y3</accession>
    <name>A0A061D7Y3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768844.1">
        <property type="nucleotide sequence ID" value="XM_012913390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Y3"/>
    <dbReference type="STRING" id="5866.A0A061D7Y3"/>
    <dbReference type="GeneID" id="24565199"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305610"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596071" evidence="2">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="299" mass="33466" checksum="45036A5A50C117F1" modified="2014-09-03" version="1">MRTLVCQLCCSLLCQPISGITVFMGSLLSPSSVFCCFDITHNIIAGRSTPHPDCPDWDHLGRHDLQAVSGIRGSESLNHKSNSNHSNEHPRTLSTLVGCSSDSANCHPHCSPITYRAYSLYSPTFAHTYLSWTVYLPDRLRESLQKLCNDMIKYKCSDGKSLYSCSTALPLLYLHGFTPPEGTSQVSLKCSDVITKLKEIVNGGPIASLMTCMDYFLYGIREPFIFSLVALWSTAFLIFANTMLYRLDILHIRSHLIRSKASHRIDVKALLTKGRKMLSLYKDVDYFDEDPIGQIGIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z9</accession>
    <name>A0A061D7Z9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0305770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768859.1">
        <property type="nucleotide sequence ID" value="XM_012913405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z9"/>
    <dbReference type="GeneID" id="24565214"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305770"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600676" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="834"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="964" mass="108201" checksum="CDDB6AE8983C3532" modified="2014-09-03" version="1">MASCRMNCIFLCCAVAFQFIGFIDATDCSFSQPAELLRDNALVTCNLDIHNFGPTEVACPRRVKHSEYVWHPQPDSNERAFTKTYVVENGIFRSVALSDVLKRETPGFYIHTESNESSRIVNIYLREEDLYAITGRRAIFICGPRDLVLTDTLQRLLDGIDGTIKAQSFPWTPATPLSQEIAKIGSGLGIFYLIRGRKHMPLQGCGNLPSPLFAADHEVTVDPISRETSCVVDPMSEARIGFLCSGRIEPPGCMRSLLDSNGNPMRVPSPYPLLNTSLHKQWVVAKYFTFRSLPPINGECKCIHPKTGRVSARIEVRSKTDYICDIASKILRNRSQPISGPWCSVVLHPGSTLTIKFPINNSNLEAPKEGDPTVTFSQMMSLHEYQTEFQPYNLNTLRQVTSGHDVDTYNEIPYHDALVGDALELDVSQMQRGEVKLKYHVDKPLSLKRGTNAFRYHLTLTSRDEHVLHRIQAIVNISFAFTHFYNMVGCDRGTPSLFNPEKSKRRCSTKSMENGIGSVYECLYYESKDFGWAGIHCGPEEELLPDNCASVGYDLYSNRIMAFPRILRSETSHPIGGFQTFSIGFQDDAIGYACICVDKRGYETSKLILEFKNHTARSYEVERAQRSQTSLSHMLLPWHRTGSSIEGSALPEYLMIHYTPEEAFTLEAGDTLSLYCEMDLGALHIISMRLNRNLNPRKKTLKWFPEQPDEFYYIVEDTPNGSVLVRRSYNDSIATTPGALEVVHRANTNSVRFPELTIRTRRSGILISKDPTNTKYVPMTFVCGNTPKQTDVTIAPGNASTSDASAQPTSNIMRSSTPYVWHVVDIDLETTDPYMQGCGVTYSSTELFKPETPKLYDADGELQFGCQIDIQTAKEAAFYCPAPYVLDPPNCFNQVYVEDEVKNLSEISQSMIASASNHFVILNFDSARIGPGETLRQTPPLECRCVTVKGVTLSTIKVENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D0</accession>
    <name>A0A061D8D0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0308540</name>
        <name evidence="5" type="ORF">BBBOND_0308600</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769137.1">
        <property type="nucleotide sequence ID" value="XM_012913683.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769143.1">
        <property type="nucleotide sequence ID" value="XM_012913689.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8D0"/>
    <dbReference type="GeneID" id="24565492"/>
    <dbReference type="GeneID" id="24565498"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308540"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308600"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1744"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="932"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="943"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1819" mass="198258" checksum="FAA6DAC282EEF310" modified="2014-09-03" version="1">MDTHGVKLDTLKECFEFLDWLNGPKGQKSNVVTELVQRLTPSFPKMPSFKRGLHVQYVNFLNNVSALRTKLLSNKITTPSNYVNTRDKTQILDALLGCIPKFLAALYYLQYHVDDAFSNVGGGDWASQSLQRGELCNFLTTGNNILRGGFSVHEVNNIEGRAVANELRKILNKEVDTRTKNPVHDHFRNVTLTISNKPWHAVNTGNTVSLVNVFCVLVAGEKDADGGAFKAALEKGLGKKICWQDLKNHCQLLKEHIDTLTGAGFSVTGRGITPTHAVNFAKTSATWFRANLPKAAGELSEMIPQSINSQKTELQSFANDKLYPRGFIFDGSKPNVLKRGLPQQWTLNLQRFNELESKLIQLKAILEGEYTASCPNLAPPPVTSSEAPKAVAPERKSARESTSTKPAVKTEAAKPVVSQSKVTPNQSQKSEGAQNQAKKVEGAQNQGKKAERNQNQTKAQSGRNPSSSSATTSSPSPSTGVKGAPGPAGPQGGKGTQGPTSTGSTTSSSSQNTVTSQHTPPQPPANPPPRADPSTPAGPVSSSKPGSGGGSANGGAAQGSHTAGASQPLPPKSSSALSPRSSSSSVSGNNGGPGPSSAPGQPGGQSKGSQSGAPSLTGQSQNPSISSSGTPSHGVPSTGSGKVSASVPGQQGGTSKGPNDGSPTAQQPGAPAQNVTTQPSSDSSPVPPSSSVPAPVGGQGTGDQGSTFSTTQQNGQGTSPSSTTAATTATTGSGGGGGGAGGVGGSNGKGVGQDPALVKQHSPTCPANQIKSVDMSGTSFCRPKPNKSYRKPLSENAENKIANAYEKTVVKNILNDRNTKHPNRKIPQFQIPPNRPTPTSPVAPGPSRPIHPTPSVQPSRLAPGPYPLPPGSRDGQGRRYYEPAEGRGRHDDGSMAVNQPSEFDGQPIPDTASKELQEKIKKKVEGIKFLKSLESTAQQEEVEQLRRDEETVNTEQEKKAKAEWEKRKQQGKGVKKHDEDLDRIQKTLQRSNRANEARLRQEEEQRKFIEAAPQLDGSQPTDDAYGEHWPWWYPGLLYREITGKPIDDDLPERLQDQRDRLFHEKIQDDLGRHIDERKALQTLERKEKDQIKKHNKDAEEELRRGRIQHMQLNPPITTVLPALPDPRELPDSLKHPDITFKVVDSTDRQSFAQKSKDAAQRIKDHYEKQRQRVADEKKVYKEELEQKEKNATQAHVESIKRAGEIVQSEHLKKMFHGGDFDIALAPSLNVDDFEDNAHEAYRIYGPSPKKTSDEIFEYNPKWNNVINYGLIVDPNPNMCNNPWNYAHDSATSSTLPLPPDSDHLPPPTNVKAMLFWLVGLNAYGLIAKMERHIEGLLMVFNGDTFYPKYALQVNGDLSSLSASHIADTLTEACLYSAHVLNGIMRMQSGDALSDIDFKLEYDKLHYSPDPACLLCQLRDYVYACCHQLAFLKAQCKRGKSLGGWQDSKYGSDIKTSSPLQAFLTDGWDSDFETHPFDPCNLCLKSRVRMGFRDKDLPKTSQQGSVISAILTPSCGGSDPLLTLASYLNCLTRRTPRTTGELVSYFHHFGNELHEYALKALSSLGTAITKSHADCPDWDCLGASDLQAVSGLRGSEALNMISNNNHDNEHPKTLSTLVGCGSDFANCRPHCPPITYRAYALYSQSFVHTYLSWTVYLPDRLRESLEKLHYELKKHDFAKCTSLHLCSTALPLLYTHGFTPPEGKSQSTVKCYDVMSKLKEIVDGKPIASLMTAMDDFLYGIREPFIYTIVALWSLAFLVFANTMLYRLDVLRIRSHLIRTKASHHIDVKALLTKGRKMLSLYKDVDYFDEDPIGYLGVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8E1</accession>
    <name>A0A061D8E1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KOW motif family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0301460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768428.1">
        <property type="nucleotide sequence ID" value="XM_012912974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8E1"/>
    <dbReference type="STRING" id="5866.A0A061D8E1"/>
    <dbReference type="GeneID" id="24564783"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301460"/>
    <dbReference type="OMA" id="FLAWDVE"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="757"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="867" mass="97300" checksum="256ABB4B247EC929" modified="2014-09-03" version="1">MARRKADDEDDDSVFGQSDDSGEDERPVKKKLKGSHSDAKRRAIVSAFLDTEAQVGDEEEEDNYDDDIFLPDESTEAERLENRSRLRRLREEGDRKDDQRRVGGAGLLENAIDKLTKRYQDRTFDEGEDDFIEDDGEDAGHDYGIMEDASVLMPDLNDPKLWMLKLNKAHSSKLVAISLLNKFLKLQSQGRHLGIYSCFAPDGVKGFIYIEADTKNAILEALSDFRNVNLRKLKMVPINEVSSIYAMESQQQIVPLIGEYVRIKTGRYAGDLAQVHESDELNGIVVVKVIPRLKEEDVDIQQQIGEDGFPIVKPPKEANASRTKTKLYIKRLFDREAIELKGGLIEQGFTPGTFRYNNMTFLDAGFLLLRISVKRLTVGSAVNATLSELKEFNLEDNYGNVAHVIKNSNLHLFRLGEKVRVTRGELINVIGHISGLHNEEIEIQPEDSSIPNFRIHPSSVMKHFREGDNVRIIDGINQGESGLISLVDFEKKNAVVFSPQKSEQFKVKLDYLVLVKESINFESLGSLNGYFLGDLIQSSKGEVGVIISISKSCFNVLLDTNNEVKLVLSDILCKRSSFGYSSKDVNNSTLYTRNKILIVSGPYKNKQGVVKHLWKNKCFVQLEKNAYVVVDSGSVLNMSISETQNPYDQRGGQERGAELRTKSRIRIPNRFIGKTVKILVGRYKGLLGDVISVEQSEFTILLKVKPKVVRIKKVDVTILDNRDLMVNKMRYASLLADKDVSKPVQHVTSLGVPDTRWVKKGVVVRITGNGEYQNKLGVIDEVIEDQADTDLQIVHIFVEEDYIAIATESVEVVRPTKRHQVVILLDGGDRIGNVTAVDGFRATVALDDGNVVEDTVDNMALYGAMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H3</accession>
    <name>A0A061D8H3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0307020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768984.1">
        <property type="nucleotide sequence ID" value="XM_012913530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H3"/>
    <dbReference type="STRING" id="5866.A0A061D8H3"/>
    <dbReference type="GeneID" id="24565339"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307020"/>
    <dbReference type="OMA" id="YVLESVN"/>
    <dbReference type="OrthoDB" id="365124at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595911" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="263" mass="30228" checksum="3ACE321DF33E1675" modified="2014-09-03" version="1">MRGWLKWILVFAAVTLKPWISHINKGFTKELLANFPKQNEADRSIAFVTAHPDDESMFLTPLLEVLSGTPLIVEGRVRVELLSLTKGELRYECHKRAYASGDFAGLGDVRTAELYALCRKYRMNCSVVDESEWRDGPAAWDVEKVAERIEAFVKERRVAVIFTFDRQGASGHPNHISVHKAVVNMKGRVAGLTVWHLHTYDILSKYFAPLAVVRSLFVSPSLIRFSPLDVIRNMRVHKSQWRWYLYLWSLFGSYSYTNSFDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L4</accession>
    <name>A0A061D8L4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766276.1">
        <property type="nucleotide sequence ID" value="XM_012910822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L4"/>
    <dbReference type="GeneID" id="24562631"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103990"/>
    <dbReference type="OrthoDB" id="336729at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="342" mass="37134" checksum="781DA052249FCE38" modified="2014-09-03" version="1">MIPPAGTVEDVVNGKTDDTINAWRGKNVIGGIGMQEMRHGAAGITANRNMAVGEVVDNHAISRIVVLPENSKIATQYIVNNALRLCRTVMCRWRLRAPHKNAGENMHLRTVENEAVVIIAGSMVMISMRRHQWLSGLSSSVSAVAANQGCQGHAVSAANRGGSSRTPKLRILVATGNIELQNGDNEKYVEEHDYKHGLFNHPQFKSISANGLLVAISATRHAVIIRRKPVAVIAEDVLTLTGGMGASSITVLPDAVKDFKAAEVQVSRQSLLAAGIGCRIVWHQPLEQVDPCEAKCLFEKSSSLEFFNFDTTLQSHGSDGLVQHALLETVKRATHNTIYVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8P0</accession>
    <name>A0A061D8P0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PROTEIN FOLDING REGULATOR, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769267.1">
        <property type="nucleotide sequence ID" value="XM_012913813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8P0"/>
    <dbReference type="STRING" id="5866.A0A061D8P0"/>
    <dbReference type="GeneID" id="24565622"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309840"/>
    <dbReference type="OMA" id="IQYAEVC"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="507" mass="56659" checksum="61E5516E032685C7" modified="2014-09-03" version="1">MDDPIDQSVKEIGHNISCLHINSGAQLDDVFRLRHLFPYSKFVNDMRGLSLNLGNFFSSYVPLLDSFIIGPGKPTVSDATLSYADKILVADLLTIGKSDDTLNRWKHLKRDFLTTNDPLVHRDNVVSLVDAHNELLQQLVNRSLEFHAHVSIFAAEKPHKHSEANVHLKLGVKKAKTIKAGTPRLQRQSRLTWKMSLPDWKGLLNWTLKHVPEDSTGNTKPIAKEDVEFLQKAMESIHDHDDKVKRAAQLIQQSAAHGAEYDTSQLLEAFDTMEQYYEEHPGNASSMHRTGMLAAVTEHVGQGNREVLPAALSLLTTTLSNNEKVQEEAAKGPLMMHLLRLRQQVTGTPLEPKLITTVAAATRHCVKAEEHFVRVGGMQYISQCTASSNLKVKEKAALLIYHFVNLQKLDKREAHKTQLLKTVRNLMPLNVATQGERQLPTPQSSAGIQYAEVCVNLFAAAVLKYPQLIDRAEAMGLWQQLSSAIQKTPELEDAKGTLQELRRALGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8R6</accession>
    <name>A0A061D8R6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LSM domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0302460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768528.1">
        <property type="nucleotide sequence ID" value="XM_012913074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8R6"/>
    <dbReference type="STRING" id="5866.A0A061D8R6"/>
    <dbReference type="GeneID" id="24564883"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302460"/>
    <dbReference type="OMA" id="PFVQQEE"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="104" mass="11489" checksum="7079EF7799CA52E4" modified="2014-09-03" version="1">MTAPSKSFRDVKSVIKLNAYLNKKVYVKFSGGREVQGVLKGHDAMSNLVLDDTEEFLRDPEDPDRVTDKTRQLGLLVARGTSVTVIHPVEGTEKIANPFAGRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D923</accession>
    <name>A0A061D923_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768663.1">
        <property type="nucleotide sequence ID" value="XM_012913209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D923"/>
    <dbReference type="GeneID" id="24565018"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303810"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="116" mass="13328" checksum="7A235DF864E9A8E3" modified="2014-09-03" version="1">MPRWPLVDGYVGKFRVNVSYNTEQQRECVFNICVKSNNFVICPRGSGYSLMHGKKAERPDNRAASRIGQGTIPALARRERLTTTYHGKKSVEWTHAVMEAKSYRDAEGEDMIGYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9G9</accession>
    <name>A0A061D9G9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767760.1">
        <property type="nucleotide sequence ID" value="XM_012912306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9G9"/>
    <dbReference type="GeneID" id="24564115"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207300"/>
    <dbReference type="OMA" id="EVCEETW"/>
    <dbReference type="OrthoDB" id="366417at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="155" mass="17761" checksum="0A394ECC1E19830F" modified="2014-09-03" version="1">MKESSKSDRKTRKRSAAEATEESIAPTAETKQEDEKSGSNWLAKFLEKLDAGRKTASAVTQQQVQESDDSSDEETTEVTEPKHQRKALSYSELLFADLSEASSLMKKSHFCQMEVCEETWQQYREFMYKKYRSQVCKLKRRAQSEGDKNTSSHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I8</accession>
    <name>A0A061D9I8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0312340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769517.1">
        <property type="nucleotide sequence ID" value="XM_012914063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9I8"/>
    <dbReference type="STRING" id="5866.A0A061D9I8"/>
    <dbReference type="GeneID" id="24565872"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312340"/>
    <dbReference type="OMA" id="VQPFDMS"/>
    <dbReference type="OrthoDB" id="364262at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028078">
        <property type="entry name" value="ACDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14733">
        <property type="entry name" value="ACDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="207"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="AP2-coincident C-terminal" evidence="8">
        <location>
            <begin position="308"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44816" checksum="E86BF6CFD9BA72B7" modified="2014-09-03" version="1">MADSAQVERPYASADSAVDVTSTSLVQGGENYGYTGEVQDIPGSGEKTNRMEHLEATESVEYGMPDANGQQLYDNGGAAYQPSDGSYTDQGWNSSGYMGLSQEGLHFSGEVPHESHMAFGNQGFDMTSTLVGSFGSVVSENSMQSADGSLHSKLLDMAQHDIMPPHGMSLKMDGGAMSGEPPRRAISKGRKNKDEANELVRRAKLLPKVMGVRYDANHQYWVATWYQNRKRMDRYFSVGRFGFEEARMLAIDCRKTAGKSLQGKSYDRPHYAHKEASANPRPTYDADNSADKSTEYYGGSDTSKKTKDFNRLNVSKVALNYILSDLCNNCLPSILENNHMPGELYIHCYNKISDHLQMIITANQSEEIEKYLHLFQLCIQNRVLPSALQVQEQRAMITTLCQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I9</accession>
    <name>A0A061D9I9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U2 small nuclear ribonucleoprotein B', putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0311110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769394.1">
        <property type="nucleotide sequence ID" value="XM_012913940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9I9"/>
    <dbReference type="STRING" id="5866.A0A061D9I9"/>
    <dbReference type="GeneID" id="24565749"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311110"/>
    <dbReference type="OMA" id="AMQINFA"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="34"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="288" mass="31925" checksum="8CCD7FB237030745" modified="2014-09-03" version="1">MMLPLPMHPVPAPRPVPQRYIQRVDADPSIPPNNTIYVKNLNDRVKIKLMRVQLREVFGRFGKILDVVALTSFWRRGQAFIVFETVEAAQNALNDMQGFMFHGHAMQINFAREKSDIISKADGTFKPRPPGPKKPRAIKEREEMQRKIFEKLQSDYLAGTLEGMTQPGDPKLIQALQSAQARMHDLTRSQPAGAEVLGKPVSHITTSAGPKGLPNRTLFVEGLPEGVGVSEVNAVFGGSLGFVEARVIAARRVAFVDFDNEFNAGYCMQALQGHVMGNSTISISYAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9J1</accession>
    <name>A0A061D9J1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-terminal domain of adenylylcyclase associated domain containing protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767780.1">
        <property type="nucleotide sequence ID" value="XM_012912326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9J1"/>
    <dbReference type="STRING" id="5866.A0A061D9J1"/>
    <dbReference type="GeneID" id="24564135"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207490"/>
    <dbReference type="OMA" id="SCKSGDM"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="188" mass="20853" checksum="CEC1738C54C1C339" modified="2014-09-03" version="1">MASDGENSAMISLPSRMGTQRHITGEPTFELLGDVWTIANQRDTTLDLSRATRTQSVQVCECDHVKLIIPDKIVSLSIVTCNNVDVDMHSSISGLELTDCTGIKIRVKSSLPSASIDKCQQVGFWITSANAEYIMFASCKSGDMNVNVNRNTSGNVDEDDWVERPIPEQFESRFNSKLQLDTKPSMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9J8</accession>
    <name>A0A061D9J8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766581.1">
        <property type="nucleotide sequence ID" value="XM_012911127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9J8"/>
    <dbReference type="GeneID" id="24562936"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107040"/>
    <dbReference type="OMA" id="WSYHKWE"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="300" mass="33796" checksum="1CD056A329E1300F" modified="2014-09-03" version="1">MDNEGESESATQDSVDNVHHQIIEDSIDKLNFVSLSSFDANKELHSAIDEDAYIISNVVTRIGISKALEHGVKLSSIIKAKALRLNEATALEVLGVVLRTFCNNFADGEEPVQIQSQSNPSDRTLDFTKLSKFFSSRTLGYSPITWDTLPQPAGEQQPQSVKRRRVQPTHTTTTIGPTREVSTMIEYNETLETEKHTESVRHKLLEASQSTPVSFWDFVLDEDPQNGYNNTCRNIYSLTFLTVKGLSTFEKDDNGIKIQGLQDPDEGRENAQGIVTGLSYDTWRKKVEERSKKRRQDGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L9</accession>
    <name>A0A061D9L9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768863.1">
        <property type="nucleotide sequence ID" value="XM_012913409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L9"/>
    <dbReference type="STRING" id="5866.A0A061D9L9"/>
    <dbReference type="GeneID" id="24565218"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305810"/>
    <dbReference type="OMA" id="RAIHIHD"/>
    <dbReference type="OrthoDB" id="361214at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="224" mass="25091" checksum="40CE097A05DA33FF" modified="2014-09-03" version="1">MASLSSVTQDLAEKLHISADKQEDHEQPTAGVESYHVLNERAIHIHDLTKHTLRQAWLLLVHSVPYKFDAYLEEGAIFPDVRPFARYTNYSSMLYMFNNAVALALCDVVKYEWPAATKKLFGKGTGRPKPEPYAVVIMALAALPKYRGVNVSKRLFDYTVKKANEARIFKLFALTDEQGAALYAKMGFTPCDDSPVKLGDLKVTDESSNPCSFTVMQYTNMGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X7</accession>
    <name>A0A061D9X7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L24 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0312060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769489.1">
        <property type="nucleotide sequence ID" value="XM_012914035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X7"/>
    <dbReference type="STRING" id="5866.A0A061D9X7"/>
    <dbReference type="GeneID" id="24565844"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312060"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="141" mass="16496" checksum="B1A134C55DFFB020" modified="2014-09-03" version="1">MFAACTARRFVSSSRRKSRKAHFTAPSCKRRIIMSAALSKELRQKYKVRSMPIRKDDSVMVVRGHYHDREGKVTQVYRKKWKIYIERITTDKNNGESVQVGIHPSNVIITKLRMDKDRHRILERKGQAAMKSKYTESDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA56</accession>
    <name>A0A061DA56_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769604.1">
        <property type="nucleotide sequence ID" value="XM_012914150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA56"/>
    <dbReference type="STRING" id="5866.A0A061DA56"/>
    <dbReference type="GeneID" id="24565959"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313210"/>
    <dbReference type="OMA" id="YCAVFVE"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14278">
        <property type="entry name" value="UBA_NAC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="47"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="264" mass="27004" checksum="8658F8CF83A51E79" modified="2014-09-03" version="1">MTTESEKVDALVAEAMEESPEDVSSDGESDVEESKGADGGAPKVRQNKNERKARKLLSKLGLKPVEGVNKVCIKKSKQVFFVVSKPDVYKLPNSDTYVIFGEAKVEDTGASSALETVQRLSQLSSALQAVSAATASVTNMANALSAVSDAAAAAQAAQAEKEANQANEVTDSPEGAESSESAAAGASAEGGEAPASARSEPKGDEAASPKEGEAAPAAAVDESGVNQGDVELVVSQVGCTREEAVEALLKNKGDIVESIMSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA79</accession>
    <name>A0A061DA79_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin assembly factor 1 subunit B, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0401130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769807.1">
        <property type="nucleotide sequence ID" value="XM_012914353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA79"/>
    <dbReference type="STRING" id="5866.A0A061DA79"/>
    <dbReference type="GeneID" id="24566162"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401130"/>
    <dbReference type="OMA" id="YKEWWNI"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="97"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="696" mass="77311" checksum="B43E546F470D3D3F" modified="2014-09-03" version="1">MPLVFLPQILWHSKDDKRCDRVYSLDFQPRPGRPQDGASRSFNLATGGADEFVHIWQVDINDNAPQYATDCNKSILAPENLKANSATGTPGVDNDVQPLTVKILARLVGHIGEVNAVRWNPNGVVLASGGEDRCIFLWAKAAKPNVLDASSQDYEEHYARFQYYRLSHVVNSISWCPDGRLIAVATEDGHVSLIDTYVEGNGKIRHFEGHTSFAQGVAMCPQNIMVASMGQDQTLRIWKRRNEKQWKNILVLKSAKDRSEFKESIGMESDDVRYSRSVFMNEELSTFFRRLDWSPDGRFLVTPAGIRHNALFKKEDEAESKNDSVYTLYIFHRKLINLGIPMVTHQSPTGPFVVVKFCPLDIAKIEKEKVNFFNKIFKTGSKNAKQKRIKSKKAVKDKEALKDASDAYMKLDSFTDLPSTANAGSDDAPYTDGVTRTAESQSQNLADELDGEVEDANGEDEPTGDVTCTPPSLVVAGIETDAGSVKEESVSDSQVTFMSSQLTDMAAKLQEAENSILTKLEADPEDSETYVAMKSEPIDVNEIDLTQSMTSVAIECEPAVDTQDEILDNDVASSGGLRSSKREIKKPQFYADTIGAPQELPRAPKPKVAKKEEEKEYDTDVEDDVVVPRLMFAAGTLDGSLCFYDTMEKKGPIAVLKNLHYCTITDIAWSPDGLVCATASSDGYITFVVFQKKEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB0</accession>
    <name>A0A061DAB0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0209620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767995.1">
        <property type="nucleotide sequence ID" value="XM_012912541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAB0"/>
    <dbReference type="GeneID" id="24564350"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209620"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="108" mass="12496" checksum="7896AEB9C2358A57" modified="2014-09-03" version="1">MRRSKNILKYVFALIGFNRLWDSTCHHKVTDDRLNVVVKFIIVQNRYYVLLNIASSIGSALRRDPYSEVRGIRRYYANSDCKPSTYVNGELPENFVSLKLSIQGKASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB1</accession>
    <name>A0A061DAB1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766861.1">
        <property type="nucleotide sequence ID" value="XM_012911407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAB1"/>
    <dbReference type="GeneID" id="24563216"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109730"/>
    <dbReference type="OMA" id="IIPYYEW"/>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="490"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="560" mass="63480" checksum="87DE235C5AF574E3" modified="2014-09-03" version="1">MGRSCQAEEPISWPWSLGETPAPTSSNKDEPPSQPEQKAESHKRPPRLSKRVMKMVRSIERLYRPPATSGMEASSINKVAASAPGTLHTLKVIDDSKKEIASDPPPVDPGEYDGIKGLVKSIYRSATGRVFNDALWKRYVHRLSVVAGTMQPADICLVMYSFAKVRYAWRLSATWMPRYRDQQLLKILNPLIVRHISGLSCSGAALILNSLKRLELSNYDIIDLATNEICIKMDTANMQDITLTANALSFFQVYHQRFWNMLFKAVSLRHHQMTPLQAALVLAALAKLDIRHPMLLRLLKDKLRPAVERNELTQELLTLTFHSFAKLNFSAKNLYEASILKYQSMLDENPETVDAQSLVLYLYTAVCMLDMPLHQTVEKSLKLLCNQKDVLKNYKAIKLKYVVDHLKTKQPGGCPSPNLNGASALLEACCSDVKGLVAKVEQYKLRNVRRRLSRWCMEVSRMLATQNVNHARNVWFDYIHADVHIKELGVVIKCAGPFSYYAMSSQLTVFAQVEIDTLSMKGFKVCVIPYHEWNALKTDKAKLDYLKKLSESWTIVEPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAC0</accession>
    <name>A0A061DAC0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">-PPPDE peptidase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0401480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769842.1">
        <property type="nucleotide sequence ID" value="XM_012914388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAC0"/>
    <dbReference type="STRING" id="5866.A0A061DAC0"/>
    <dbReference type="GeneID" id="24566197"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401480"/>
    <dbReference type="OMA" id="INWTRDS"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="237"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="410" mass="44565" checksum="E04E617D11D77051" modified="2014-09-03" version="1">MSEDLSTVGKMEGPQLIIVDATKVEKDGDKRIFGDIKNVSSTGLNFVTLKHIPATITSIVSGSSISPQIIEHTMDSAKMLDLTKLRTGSNTPETAISPREPIAVPNDISAEHVINMSKVVTRIGDGSARRTGDFNSPRSFHIAEQFKMIHSKISPTVSNASGTVPISGAAKNATTPYILTAREITRNTDVPSLDSTRMIRRGYSDDVAMMLKKGSNRLIKTHSHSSPRGKDSPAEYGHVYLNIYDLEAVNRVVNVVAGTFGAGAYHAGVEIYGYEYNFGYTPQGGSGIVQSHPRFHSSHKYRKSIDLGKTKFSPREVLQIIESLKPMWLGSSYDILKKNCLNFADALCKKLGVGSIPSWVMGLQNKINWTRDSLQSGAAKLKQFDEAVGISRAFGTLSRKLTGECAGGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD0</accession>
    <name>A0A061DAD0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAJ/HSP40 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0308360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769118.1">
        <property type="nucleotide sequence ID" value="XM_012913664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD0"/>
    <dbReference type="STRING" id="5866.A0A061DAD0"/>
    <dbReference type="GeneID" id="24565473"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308360"/>
    <dbReference type="OMA" id="GMCFTVL"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595612" evidence="2">
        <location>
            <begin position="17"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="288" mass="33122" checksum="7882D2B801FFF581" modified="2014-09-03" version="1">MIKFLILSFVVSPVVRFVVSPSRELAMATMFAIVFYTSMKSEKNYFQHLKVTPHCSLDAIKKSFKAEAMLLHPDRNTSPTAASDYVELSQMYKTLVNDKKREAYVRYGDMLRGRKEQVVDMSPFDVLYVVTVNTASMLFGMCFTVLLHGQSVVNLTALLYEVFCFALDVYLRFAPDATSFLAGVPILKYYTVFEIIAFLRSFRLVFLYYHSLMGDDDEDKKWKAGICLVRNNMVTVDLLDEYIVAVQRYLTSRKPVVDSEIVWRGAPSVGNAFENRWNYSGNWHVYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD2</accession>
    <name>A0A061DAD2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769694.1">
        <property type="nucleotide sequence ID" value="XM_012914240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD2"/>
    <dbReference type="GeneID" id="24566049"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400040"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="84" mass="9382" checksum="E7C29D2F36C8EC53" modified="2014-09-03" version="1">MMCTDVVFCNSYATIHSPVGGQHGARQVRGPTRKAGELRGKRVHRSGARGTEVRERKANGNKQKGKWTCMKGRGVSREARKRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAJ1</accession>
    <name>A0A061DAJ1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0402030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769897.1">
        <property type="nucleotide sequence ID" value="XM_012914443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAJ1"/>
    <dbReference type="STRING" id="5866.A0A061DAJ1"/>
    <dbReference type="GeneID" id="24566252"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402030"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="11">
        <location>
            <begin position="274"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="518" mass="57110" checksum="A421539C19E21D84" modified="2014-09-03" version="1">METAVKVVAAIDQGTQSTRCMFFDEALNVLAISTKKHKQYYPKSGWCEHDPLEIMESVYSTMNEALSKVVADHGNVEIMGVGITNQRETVVAWEAQTGKPLHNAIVWLDIRAEDIAHDLIREHGSATAFMEKTGLIINSYFSAVKLMWMSKHLPWFNNAVENKSVRFGTIDTWIIYRNITTIQQNLTGEYVTDVTNASRTMLMDIVKEKWSSQMLRIFRLNVDVLPKILPNCAEFGVITNPNVPGFVNVRLTSSIGDQQAACVGQGILEPCATKCTLGTGGFVLTNTGTKRVKSSGGLLCTPCYKLGKEAQTVFALEGSIAIVGAGISWLKAMGIIEAESDISGVLKECKTSGGVVFVPAFSGLLAPRWRGDARACIMGMTQHTERAHIIRAFCESIGLQLGEILQSLLTDMGVDKVPYICVDGGISTNEEILQLISDIVDTSIELFNAEKSAVAEATCAGAAILAGVQAKLWNNVQDIQQFIRERPKKWMPRMSDSERDILIKYWNLGVERSMNWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP9</accession>
    <name>A0A061DAP9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769248.1">
        <property type="nucleotide sequence ID" value="XM_012913794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP9"/>
    <dbReference type="GeneID" id="24565603"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309650"/>
    <dbReference type="OrthoDB" id="2193044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12217" checksum="613492664175D6E3" modified="2014-09-03" version="1">MIKGDIMGKGNDRTQKTKEYNRPDIILADRRKNTITIVEIGITNQYNPVDTDKFKKQKYEDLIEDLKARQFNQQTKIRVIPYVMTWEGIVTKEHSKYRRDLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB42</accession>
    <name>A0A061DB42_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0403840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770082.1">
        <property type="nucleotide sequence ID" value="XM_012914628.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DB42"/>
    <dbReference type="GeneID" id="24566437"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403840"/>
    <dbReference type="OMA" id="QMIMGEG"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF28">
        <property type="entry name" value="UBIQUITIN THIOESTERASE ZRANB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="2751"/>
            <end position="2917"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="3172"/>
            <end position="3203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1644"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2933"/>
            <end position="2958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3704"/>
            <end position="3788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2936"/>
            <end position="2958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="3704"/>
            <end position="3714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3723"/>
            <end position="3742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="3756"/>
            <end position="3767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3768"/>
            <end position="3779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="4416" mass="498364" checksum="65390A9347320EF6" modified="2014-09-03" version="1">[encoded data, 4416 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB96</accession>
    <name>A0A061DB96_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0201720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767201.1">
        <property type="nucleotide sequence ID" value="XM_012911747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB96"/>
    <dbReference type="STRING" id="5866.A0A061DB96"/>
    <dbReference type="GeneID" id="24563556"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201720"/>
    <dbReference type="OMA" id="AQLCQTT"/>
    <dbReference type="OrthoDB" id="10036053at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="106" mass="11917" checksum="20612931A7D3AC5B" modified="2014-09-03" version="1">MVSKKIEKKVKKKVRSETYGTYIFKVLKQVHPDTGISKKSMMIMNSFITDTFDKIASEASKLCKYNKKETLSSREVQTAVRLVLPGELSKHAVSEGTKAVTKFTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB0</accession>
    <name>A0A061DBB0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769989.1">
        <property type="nucleotide sequence ID" value="XM_012914535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB0"/>
    <dbReference type="STRING" id="5866.A0A061DBB0"/>
    <dbReference type="GeneID" id="24566344"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402910"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="681" mass="70938" checksum="5471D252632EAABB" modified="2014-09-03" version="1">MADSTGEAKPTHLATTVSIGKGEEGNEGIYGTYEGSTRGSDTIEHRGTNENKMGSQAAYEGRAYPSQAAYEGRAYPSQAVYEGRAYPSQAAYEGRAYPSQAAYEGHRFPSLAAGIRDILASQAAATSGTLAPPAAYEGHRFPSLAAGIRDILASQAAATSGTLAPPAAYEGHRFPSQAAYEGRAYPSQAAYEGRAYPSQAVYEGRAYPSQAAYEGRAYPSQAAYEGRAYPSQAVYEGRAYPSQAAYEGHRFPSLAAGIRDILASQAAATSGTLAPPAAYEGHRFPSLAAGIRDILASQAAATSGTLAPPAAYEGHRFPSLAAGIRDILASQAAATSGTLAPPAAYEGHRFPSLAAGIRDILASQAAATSGTLAPPAAYEGHRFPSLAAGIRDILASQAAATSGTLAPPAAYEGHRFPSLAAGIRDILASQAAATSGTLAPPAAYEGHRFPSLAAGIRDILSSQEAGIRDILASQAAATSGTLAPQAAYEGSAFPSQAAYEGRAFPSQDAVAGDILASKGAVIRDIFASEEAGRGGGKDDSRAAGSGAGKDDSEAGYKGVRCKALRKFRKPIKKRFRFRSEYDRNSSSTSESCGSRNMEQVIIDTAKYAEDISTFVKHIAENLDRLIHFGPPPQKHHSERDKNDNAREDVEQSSNDTFSAGSEDGTEDLPPEDHNSESEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBF6</accession>
    <name>A0A061DBF6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0405200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770222.1">
        <property type="nucleotide sequence ID" value="XM_012914768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBF6"/>
    <dbReference type="STRING" id="5866.A0A061DBF6"/>
    <dbReference type="GeneID" id="24566577"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405200"/>
    <dbReference type="OMA" id="CQHEKSV"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR98036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="204" mass="22376" checksum="5FCD18C0803F9F38" modified="2014-09-03" version="1">MAKRKTKKVQLSRAQLMQKRRGKLDKEFLCYYCQHEKSVAIKIDNQSGVGFLSCRICGVKFSTRVTVLDEAVDVYALWMDSCREGQRSDTLPPKKNSVDTPSTQGTIQGKTVATKAQAENEAPRADISTPAADDATPEDAVKRSREEDSTTKSFSIDPELASAAFSAIGGGKRSKRIIDAVEETPDETEYAVGTLTGDNLFEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBG0</accession>
    <name>A0A061DBG0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768425.1">
        <property type="nucleotide sequence ID" value="XM_012912971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBG0"/>
    <dbReference type="GeneID" id="24564780"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301430"/>
    <dbReference type="OMA" id="WPWWLEK"/>
    <dbReference type="OrthoDB" id="363816at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="7251" checksum="435E496E088BCAC3" modified="2014-09-03" version="1">MGAHSYGLFFRKGWFTRTIVKTAGLFIAADAYVKYEYGIDVNYDFNTTAWNWWMDKTPEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBL2</accession>
    <name>A0A061DBL2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0404310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770129.1">
        <property type="nucleotide sequence ID" value="XM_012914675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBL2"/>
    <dbReference type="STRING" id="5866.A0A061DBL2"/>
    <dbReference type="GeneID" id="24566484"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404310"/>
    <dbReference type="OMA" id="HTKDCPG"/>
    <dbReference type="OrthoDB" id="436717at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595654" description="NFACT RNA-binding domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="602"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="717" mass="78457" checksum="981089F352A6662A" modified="2014-09-03" version="1">MLVSLMSVLIIAASIASVRTGAMLSRGCRALTFAAPASRRVKPNLVAARRGISCARARVSDSAPADMHSYDQLPRHPATPDDCIASFDTIKNDEVVLQPPPTEKSGAKNVAVDFGMLRRYSEELNAVLANATFNGVTHIPLKKWYVEAKPLEAALLHFRGFERGDSLCLFYQRAGFPLVPSPSASYIPATERQLSYFETVMSGLSGLRVTKVHCPYFFKSILAIDLKPAYQHLGDDGGDGPAESYRIMFVARRAGNRFVMTDNKDGIILLTSETFDEKSGIKDGVGSVFQAEPSHKATPDPSESYDDFASRFMGKQHMSLLKAMILTYEGLDARRVTLLAAKAGVDCTRHVSKIDNLADFHNTFIRWVRSSDESHSQLHFVAGDGNSDNDGSVDQGDSDVDTSREGLGEPNQTEDATATNSNADPVDEPSSPAGNSVGSSGPKTIIDYVFHHWGSNGPVYAHQRLAEESRSLIDSTLERLEKIRQQCIGDEQQVERLAKVTERINTINEYSKSLCTAMKWKSPEQFDLVRTIYDQVFDLGDLTGYRSKGRAVRGGSNRDNTGGADNDDEEAERNVPRARVKKVNPYKGILVIKTCVQDPNTPLIIVGRNAEQNERVTHELSLPGDIWLHTKDCPGSHVLLRRHGGSAEALQVAADIASHYSKAKFRAVVDVIKTGIENVTRCPGAKIGAVLVSNFVTITGHPARGGEYVKAHRVSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBP9</accession>
    <name>A0A061DBP9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exosome complex component SKI6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767361.1">
        <property type="nucleotide sequence ID" value="XM_012911907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBP9"/>
    <dbReference type="STRING" id="5866.A0A061DBP9"/>
    <dbReference type="GeneID" id="24563716"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203320"/>
    <dbReference type="OMA" id="ENQMLSI"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="33"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="254" mass="27815" checksum="1E8EAE3F8538A562" modified="2014-09-03" version="1">MAKIEYISVEGLRVDGRRPAEVRNIEILCGPECGVDVNSYDGVAQVRQGLTKAQAFVKGPTDVGRNKQRSQLETSDSPVEIQCEVVMPCEKRVIGNKMDHQSADIAQTVIATFERVVVSHFYKNSVIHIFVNVLENDGGVKATVINAVLVALVHAGIAMRDLIVACTAAMLNRQLLIDPNQLELNASVMELTLAASVSKEEIMYLDLKSKHAIKSVDGIIIKTIEASKQFSILAKAKLKNYARDYLELNSAVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ0</accession>
    <name>A0A061DBZ0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0314040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769688.1">
        <property type="nucleotide sequence ID" value="XM_012914234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566043"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0314040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0314040"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1563" mass="176783" checksum="E47FD5A4B6178ED5" modified="2014-09-03" version="1">MGFLYYLLKDVSEKQPYSVGKNILINNILTLINNHLCSGHEGFKELFRVLPARIAAYNRDVRESNNRVRTIITTMQSNMQKLETEVSKITIVNAVAGKSREVAQAEWLVKQRLADCWKYAESFTNDLDINTNSIDNRNAINDLNSSLREKIENVRVTIEHETKRLTELSKKEREELTATKDFLYAEIDELKKRLHTTIDKHIKDLVEQLKKSVREILGQLESLGTRFRDHIESLRKWMEQAENLIDDAEKNVDLVSGHVNGTSSTYSSQHKAAMEQFEREAIQVFEAASMAKSEVEKLVQEATKLVGQLDLAIRGDLYDMKGRVDAAIRECLDNINSALKAGINAAKGYEWVQNAGPAVEAMEKAVIGELNGKLGTIGEPVAKVLAQAKKSGKDELGKHLEWLLNDLNRVVGHNTVESTDFIKYLAAYFQTPLDKELPQDRLNDGKVTIDPKKFPFYSGTDNGKKQALEAAISKIKNDGVAALQIIDASGGSGRITRDTFETHANLVTHHLNELYGAIKQAAEYSKQNLRKLKDERFKQYSNGARDANDSIRKIFTELGDLHSELVAKPINKVKEFLQKGAKQAEDYYARYLKQESDKEVEKFKNLIYIHAQMQYGASVKSLLQAFCEKSIDELYGLPESITLDLDSGFKGFMKQMETEFIDKVKEVKQIDVSDSTQQSPLGQAAHYIHRAFGYFFHGLKTQTNFMPNYEFIKPSRNALAELLHGLTNSKHYDPTFRNNLQTFDTLLHAFSPMMLEGPPHPQLLDILKTGMEALAFELHKAYVNVYEGTNFVTDWVHVIENRQKPQSGVAPTDSPKHMLTADGRDCAKVFMTLLEILGHDLSEFYNNCNMTDGTWRDRKISETYKSGINAFGQFLEYCGYTIPKGEGSKQDGELRCSSDMKGEKIYERLVTRIPIVAANSHFKTCSLHNDEATKFSMMGLLSCITGHLKEYYQVCHYATSDAKGQPRSVYEMLQWLSGLPNNAVHQKLSFDYFAELFDKPKTEENGGNADGDVTFENLEDRHLDAYPERITVGNLTTTLTDICAQSHSVLTTILGHGQAAGRYACDFNTNEAKLSYPSNTAACFDMLVDIVYRLYDQLYFLFIQCERTSDTNSWRDCWYGRYVGGSSWECNTWQCHNLECNQKANQIANQSDDQNANQQCDQHPKCGLKSPLQSFLEDGLPGFLPHQFTKPGCKLECTVSKHRGVPCKTPMGFADISIAASHTKTGAEISAELRDFCGGAETPLGKMCSYFICILQRTPQTLGDMFAFYYNFIVGWDQSGTKHRSYAFNNAVTKAYFGQQYSGLDVKSLLNVEPSSKHDKGNLMCLVDCNNTAQGRVTCGRYLQSFGFNTWRMFADKHAGNYLSWIVYLTETFYQLLKGLYDECCNNCNKPGTRCHGKICPDACTVKAAYKAEDPQKSLNGQYHIKDCKSIATCPFTRPTLYKHGFTLKSLSNLSGINGDNTKRTCQDFCNELKIIVDEKSVLLQMFYKIDDFLLAIRFPFMTLTLALWLLSLLYLIHIMVTRLDLLHIKSHLHSPSSHRIAAQSLLAEARVSKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC73</accession>
    <name>A0A061DC73_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0401290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769823.1">
        <property type="nucleotide sequence ID" value="XM_012914369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC73"/>
    <dbReference type="STRING" id="5866.A0A061DC73"/>
    <dbReference type="GeneID" id="24566178"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401290"/>
    <dbReference type="OMA" id="YFNQHTA"/>
    <dbReference type="OrthoDB" id="408413at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="509" mass="57225" checksum="14F2C6ABAA03B748" modified="2014-09-03" version="1">MAALRGFFDIGVGANLSGRVVFEFFDDAGDSIAENFRLLCLGKVVGSVLGKRRTLSYTGCRVYRVVAGQYFECGDFEHNNGDGGSSAFGGYFNEAPNTRRHSQAGLLSMKRINKEGYGSQFVITLGRDPRLDDRHHVFARVVQGMEFIRAVENVPLDARNAPKVEVGILRCGLLEYTPRKVGQMSKQRDLVNTLMESLRPNDSDSDEEEPEELRCLYTGKVIRKRSIRPDSAAAIGKQYVAEALGGKSLHFIPTYDADSEYQYYVEPDAPAEPKPAAAAVEAQGDTSESSESEDSASDDDGDDEDPLAQKLRALSKRLDECSQLNQESVEVEHKLGGDPKKLNEHYKSVLGLREDNSTVNFNRNPSLNKAAIAVEKRHQQALKKEKGKTFGWNVFNQDALYRAHKKRLNETAFNQEEYELQKAQMGDNFYKPGITSTVPTEAAKLTVVRNLEKQYKQREKFSRRRAFDDDAKDVSYINDRNRVYNMKLDRAFKTHTAEIKQNLERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCD7</accession>
    <name>A0A061DCD7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0402260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769923.1">
        <property type="nucleotide sequence ID" value="XM_012914469.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCD7"/>
    <dbReference type="GeneID" id="24566278"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402260"/>
    <dbReference type="OMA" id="YWTPNIK"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="7">
        <location>
            <begin position="762"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1341" mass="147160" checksum="3BFEBBD03FD3E894" modified="2014-09-03" version="1">MQLGIKAYFATRPRTVSIGSNDTPSSDAQSGVAKDVVAPAAADNPSADPEVGKVVDVAKVPSLSPSLRNSDPLKDEDALKRTYTCESVAPAEPRPDSIDTCRVSTSDASQQDAFDDGDESPICRKRSLMFDNGFVPEKLKCTEITDEFIGAHLDVIEHFIAQSDTAGSYTAGTQGVLAGGDASPETPKDCPTTTVSPNERTSSLSPADSAVAGVGTLGSLRASGTRPPDVDDEPGQGRRKQARKGGRASSGKDEGAATKRVATQYVGHDGDVEELTFVDRREVEGGSAVATAGKLTVGSEKFTACSQSVDCVTDEERKLYLTCPASQKSRCFKAYVEHYYRYNETFVFPPWVQIREIRDRNGLRPTDESYDPSTLWVPSRSHRWAVAFRSCHFTECMQQWWYVKQDRFDQLLFFKMGRFYELFYHDACIVQEICGLRWMGSEAKPHVGFPEKSLHIYASACVARGYKVVVVEQTETPQQLEQRNRETGQRQNTVSRAICEIITPGTITRPDMLGTQSKQLLLIAEAVVPPAATAPVAAEAPTAHVGGTGDLAQPSTPTARAKTNPSFSNPSTLSSGRRNSRFGSRRRQTNEIKDLPGERLLCICSMDASMGTIALGMVDISLGLGELRALVASVNPAEVVVDAATIGSLNELYGMTVYMGFELTSFNCAHQFTPENVGNSDVKIAEVDYGAFEERAKAALGSSNAAYERLMLLLQRYLRSVMLDNLLNYCAVKTLGADNYQYMTLDGAALTQLELFKSQEGDNSACLFGFLNKTCCPFGERMLRRWVLKPLMSAKRINARSRTVEFLSRNFSICSTYQEQLSLLPDLERSFGKVLNAAAGCYKMAVYFDEGVFTKIYDLHLLLANFDRLQQHVSAFFSEAAEYGAECPSLLREMSSSVAKVTGHCGELNARLNVTGLKTCSSRPGVWKESDEVRSRIDATKSRLDALLVEIQKTCPSACFVHTKFRYEVELNERDHRRLSQSGKSLEITSTKAGHVRVRTSRIVSLVNELEEHEFALTQSELTFFQDAVRLLHDRRGVFSELLVTAAELDCLCSLASVAKHAVIPLVRPEVFERGSAEPYMYLRASAHPVVSQLTPDSFVPNDIHLNHGDYGNLLLITGPNMGGKSTLLRQTALCAIMAQIGSFVPASECRMTAVDRIYTRLGASDNLMQGKSTFLVEMEEVSSILHTGTKDSLVLVDELGRGTSTFDATAIAAACLEKIDSIGCRCLFTTHFQEVCAYALRLPRVTLCHMTAAFDDEARTLTFLYKLAQGQCPESHGIHVARLAGIPPNVLEMAEKVSRRFRAQKRSPAATLGALLGAHSRGDEAVLRALYEELRQPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCG3</accession>
    <name>A0A061DCG3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769963.1">
        <property type="nucleotide sequence ID" value="XM_012914509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCG3"/>
    <dbReference type="GeneID" id="24566318"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402650"/>
    <dbReference type="OMA" id="YWSYEAP"/>
    <dbReference type="OrthoDB" id="365493at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="195" mass="21575" checksum="545FD98AF6518FEF" modified="2014-09-03" version="1">MDVDSGPGEAIQPPESTDGRVFYRPSPDTYKPRKKVLDEAEIETVTADWHFSDEFVSTQEPGSLVENKLPWQVKWYLRFVPPKSPEELEIGKHWRYDAPSLDGLLSVAPEKPTVLTPTPLGGLKSMAMKVLSGIVQDSLAQNSFQKACEGYITRDTAGSTVSSQLRMPEGQSGNKRSILEAYTSQKEKAKTAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ9</accession>
    <name>A0A061DCJ9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767801.1">
        <property type="nucleotide sequence ID" value="XM_012912347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ9"/>
    <dbReference type="GeneID" id="24564156"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207700"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="102" mass="11860" checksum="8973FC2E5C31A57E" modified="2014-09-03" version="1">MTDVNHAFIRRLMTDVNHAFIRRSTADVNQVFTRRSTADVNQVFTRRSTADVNRVVKKWWCTYVATLVTHNPKFYEAVPHASLLVERMPVTAKQSVRGFIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ6</accession>
    <name>A0A061DCQ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770128.1">
        <property type="nucleotide sequence ID" value="XM_012914674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCQ6"/>
    <dbReference type="GeneID" id="24566483"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404300"/>
    <dbReference type="OMA" id="DIKFTEC"/>
    <dbReference type="OrthoDB" id="430737at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="635" mass="70252" checksum="C3940859AEF3A16A" modified="2014-09-03" version="1">MRSLLRRFAFVLRRYYRVYPGRKRIQVETKIKSPKRYDELRGGSPTTLLQGNLFTPESAGPRELAMLCFRIVSMGYADASILLRYAQCAVKQIAQLRIKHIALVLHSISKFLAANATQMGQPSGSEVEAFQAEIANREQLLLTVDELVKAATPNLQKLFARAVPKDLGMIALSLVTVCECAFRELGADHHASLLGTTEQTLKLIATSIGPKLPFCEAPEYAALAKAFCKLPPQLEFAGLFLRDLADEVACLLLEKQEQLEELNRGSYIGDDLLESLMELPKDLTTIACALSRRVHRHRMWKRLAEFVELMLKVNEQGDGSFARLDGQTLILLATSLSRHADVGFLLNALLAQTAAKPRPQWLITGMDIALNALNDVDLGQRLWDSIDFAQVPALDDAAKTQLVHASMRVRNLTEEQKAVVRGLVSGDCSKELLVALYAARHRCGIDRTTQLLDAIMADVDRLGVSSLMTMLRNVEGVRGLPSGDSQCDVGENHDSEHVDGDSDLIGAQEAIKAQLFNALGKKVESVPLSKLYEILLYTIDNHGGRVAVIEKMAVRVGQAAAEYQDHHLATLIERLRGVGINPERVFETSLVERLQKDNGDVDPQLVDSFVEDGMPQDSRAEPKFSELGEFDFGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ8</accession>
    <name>A0A061DCQ8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0208690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767901.1">
        <property type="nucleotide sequence ID" value="XM_012912447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCQ8"/>
    <dbReference type="GeneID" id="24564256"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208690"/>
    <dbReference type="OMA" id="AMQNTED"/>
    <dbReference type="OrthoDB" id="363961at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596025" description="Lon N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55458" checksum="A958956824BD999E" modified="2014-09-03" version="1">MGFRRTAKLIAVAIAGIQRAEALQPRHHNAPTCAFHSASEAFLVPTCVSSRSAVQNRRPAERFALDTDPGKDGDDEQSNKASEPGRIHDDREDHTTVHEEYERESIEYIDKQLLQQSGERTADNGGAGEQEADKDNYFNWDRVRDNRNMTSDEVVKSVDSTGMRELEKGPRPTLAGRGTDMRLNIEDFPTNVDTGRLNEWVPSWHPGEKVMSFFPILIDQYSLLPSPLQLGFEDPVVFRGKYVDMTFNSLIDNVAMPDGSTKQIYGMCFINPNSGQLAPLAVYAELLSREAFVDGGGERLKVKGRVLGRVLLHQVVMEEPFIKAKIIPMEDDPKFTELDEVPKLVDEITSLHDMCNKVECEMMELMGQHYAVARIKSRPELHDVIDQRLDHFDIDLATGAQAFAQIAAYTAFDFHLTADERYDALTMQNSIDRLRYVRDSLRSKLKQLNILKKAPRDRLEDILEQMKQMQLNREEAAESVANEGDQNGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCZ2</accession>
    <name>A0A061DCZ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Triose or hexose phosphate/phosphate translocator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0405760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770278.1">
        <property type="nucleotide sequence ID" value="XM_012914824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCZ2"/>
    <dbReference type="GeneID" id="24566633"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405760"/>
    <dbReference type="OMA" id="FWYTVSS"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="54"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR98092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="352" mass="39755" checksum="82AC0F915B448323" modified="2014-09-03" version="1">MEVNQKNVDASDVAFANLHDEEYERALPASAFPEKRTKRTWIEYILGLDWWLIIGFVLWYAQNACYVVFNKLFLNELPLPWTLSAFQLLIGWFFMIVFWGCNIRDKPNFDNVRKFFVTFLPMSFLHFLVHVSAVISMGLGAISFTHVVKALEPVITVILSMLCLHEFMNVYAYLALIPIVGGVALASIKELNFSIGAFLFAMLSNVAGATRSILAKVTLKNKADIGENLTANNIYMILTLIASLISLPFLVGFEARHWIPVWTKATANMTQSEKLWLLFYGFASCFFYFLSNDSAFYCLGQINQVTYSVANTAKRVLLIASSIIVFKNKVTGMGYIGMIFAVLGTFVYSMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD60</accession>
    <name>A0A061DD60_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP synthase subunit C family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0310320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769315.1">
        <property type="nucleotide sequence ID" value="XM_012913861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD60"/>
    <dbReference type="STRING" id="5866.A0A061DD60"/>
    <dbReference type="GeneID" id="24565670"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310320"/>
    <dbReference type="OMA" id="LMSAIMM"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR97129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="160" mass="17090" checksum="6341CAACC10E6ADD" modified="2014-09-03" version="1">MAPIQRLFASALARNSHLTSPLGARFLSQVPSFQRFDARQQTRPTAAELPKSLYIHQNGIQNALLTNFANRGNMASLAPFNNKFGARYDGGIATLGAAVALMSVGGVAQGIGNLFAALVSGTARNPSIKEDLFTYTLIGMGFLEFLGIVCVLMSAIMMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD62</accession>
    <name>A0A061DD62_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769320.1">
        <property type="nucleotide sequence ID" value="XM_012913866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD62"/>
    <dbReference type="GeneID" id="24565675"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310370"/>
    <dbReference type="OrthoDB" id="364375at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="270" mass="29716" checksum="4697AE3A4622E0E5" modified="2014-09-03" version="1">MVLLYVLRWVIAGVAVLVSQCSIGYAFRGASGTPILGALPALRAPLYGKNRHCDRMKRIRRDQYFYGRRRDLDALREPGGLEHALGIQRHALSAVFGRPLSQRLGDGGIIPYLSDASNKVAHVMEYFGVPIDEEGEVAELCASVARHPTTTRGEFKGKPPMTEKVFYRDPSVPEEESEFNRAADYQSGMAPLIPQLGANDHEHRFYSGLWTEVAFRKLPKQLVDEMVSMEIDAKQGRVDGSKLRRKTAGFPGLSDSDGSGTSGTPPTPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD89</accession>
    <name>A0A061DD89_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl peptidase 1</fullName>
            <ecNumber evidence="5">3.4.14.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cathepsin C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cathepsin J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl peptidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Dipeptidyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0212020</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.</text>
            <dbReference type="EC" id="3.4.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.1" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768246.1">
        <property type="nucleotide sequence ID" value="XM_012912792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD89"/>
    <dbReference type="STRING" id="5866.A0A061DD89"/>
    <dbReference type="GeneID" id="24564601"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212020"/>
    <dbReference type="OMA" id="CYIASQM"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0868">Chloride</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018594735" description="Dipeptidyl peptidase 1" evidence="16">
        <location>
            <begin position="20"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="17">
        <location>
            <begin position="251"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR96060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="520" mass="58258" checksum="A9BBB42BCE4D1A3F" modified="2014-09-03" version="1">MLPLLCLIHLLASVVQVRADLPIHALVTDISGKWRIFQSRAVGGLDVACGSDVPNSPEGNLLLGNYLAYLKTHFCLDRTTDVHLSLDVTAYSDNTNAPNRSMWRALAVKDKRGNVVGRWTAVSDQGFEIIFHNNARYFFYLHYTKRDGDQYETDVTKTQIGWVYEPQGSSDAHATRRCAYAARVDGTKPRVSTIVQLKSNDVKNKYRQISRFISHDTGGVLSAASNKISPKKGPYPCDCSSRNQLDFDDDVPESFVWHTQATIPVVNQQQCGSCYAIATKYVLHARFLIALERCGERTPEQEKALEELSHNYFYPEDTSDCSMFNQGCKGGYPYLMGKQMHELGISVVKGNAQQCAILSAERRYFAKDYGYVSGCSQCTACQGEELIMREIYANGPVVTAVDAAILNTEYDGSVISPVDSEHNSGVCDVEQHPILTGWEYTSHAVAIVGWGQQLEQGKMVKYWLCRNSWGPEWGEDGYFKIERGKNVFGVESEAVFVDPDLSRFKQAPADARLHDIHYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD95</accession>
    <name>A0A061DD95_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trehalose-6-phosphate synthase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0212170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768261.1">
        <property type="nucleotide sequence ID" value="XM_012912807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD95"/>
    <dbReference type="SMR" id="A0A061DD95"/>
    <dbReference type="STRING" id="5866.A0A061DD95"/>
    <dbReference type="GeneID" id="24564616"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212170"/>
    <dbReference type="OMA" id="TSWDKRR"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05467">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000052">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF94">
        <property type="entry name" value="ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="968" mass="110641" checksum="B7729C61DB2B2F08" modified="2014-09-03" version="1">MVFFTGVHFRCRAGLEFGQRLVVVGDHSALGDWDFGACHELLQSATVDDVWNSRAPAHLPLNKRREYRYAVLNDLGEFLRWHEESARFVNPTGNEMLVEDDDGYYRDQCAKLITSGDEQGAPVAVENNIDSKNPLQVIEALRGLDVDPNLTVYFVTSRLPIQIKRGADGSFSIRQSNTPLTTTLWKTRNRCRNKMRFIGACLITPESAGDDGDGVDPPPASERREPDKDAGGDHFTDDEKEEIRMLLLEHDCIPVFVPPAELNESLRFCKEHLWNLFYNIGLWDVNKQREFRWDLWKSYVSVNRQYATAAAINASEGDFFWIHDYKLLMVPHFITRRIKRANIGIFMHAMFPPCSLFICLAVREIILRSMLCADLIGFQFYDYARHFLTCCKRLLGLDHSSKPGGMLDIEYNGREVMILLSHSHIQPDLLATMLEERNGVPALVESFREQWPDRFVFGSLDRDIRLSGLYLKLKAFRLFLEQCPSARNKALLVQYVCAKDTLWECRRDTTERLQSIVDSINADFGGTHVVLEFNVSIERKYALFVSADCFLDASIRGGINMRALEYIYCRQGKPACAILSEFVGFSKMLLSAMRVNPWHIESVVDAMRTAMSSKSEERVEVCRRDFEYIVSSDTVSWADQFIRELFFARKRQDMLHLTWGFGKTLKTYSVANTFQHLSIDYVLNSYDAARRRLIFLDCEGTLSASLWDTPPRSPQDCERSIRMGISPLECNVKSIRTLAEDPLNIIVVISGRGRECMEKLWFPDQPKLGLCAGYGLYYKVPCLTGNEWCCMLETFNEEWKELVVQIMEQYAHRTPGSYVEVMDAVVVFQYHHSDPEFGATQSGELYTVLKCAMSKYPVEVQLCKWNVMVRLKGVCKGSALLNVAKRYSALHGDLDFVLCIGDHRSDEDTFKALETMSQWSKKGDGSPTSDDKSRSFISVTVGMKPSKAKYYVNDHTEVSELLTALTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD96</accession>
    <name>A0A061DD96_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769395.1">
        <property type="nucleotide sequence ID" value="XM_012913941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD96"/>
    <dbReference type="STRING" id="5866.A0A061DD96"/>
    <dbReference type="GeneID" id="24565750"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311120"/>
    <dbReference type="OrthoDB" id="367189at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="586" mass="65359" checksum="2B7053FAE2EA2C55" modified="2014-09-03" version="1">MIKKAQEDAAERKRRNDEKIKRQKETELGKREDEERKIEDERQLQREAMLPGIDVVFKARESSDKSLNAYLDALQNQLKSVPPTVGLQVTVPSRYDANSDDNPDVFEFGKSVTLNIVKPDLIDVDESVEADLDKTLVYNSDVKGDVLDHVNDIMIVDVSGEDVPEEPDPVLDKPSHAKTQRIVAQHNVDSLICGQATSDAKGIPDFAVPQGSSAIGVPIGYSIKPPKLPKIPPPPPPTMELTGNLIPDHALKYSWLPPPRIHIETAPRNLPIINVDIEKPYTSEHIMQTELRRTTYLPHEMVDPEPLPAYNVNLDIAPKLKVYNNSSYMPTAELKPQPLNNPDFSIHIPKPRLQDTSYDLKIDEPPPLQALQPLDPIDPYTTSINLNLDAPEPIPELPNKSAADYTHNTSTLQMCVSSWATPTPTPSSTDIPDTELFPSQVPRTVREMLTWLAGLMNEKHHYTLEKCINKAFSGLYSDPSQLALSINGSYVRPTDVFDILQLTAMFAGSVLSAIAPNWKANVSSRTMTTKSTTQSDEPDCCALLCQLRDYVYASHYQLEFLKAQCNRDESHGGWQDCNYGSDTNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA2</accession>
    <name>A0A061DDA2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768281.1">
        <property type="nucleotide sequence ID" value="XM_012912827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564636"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212370"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="1673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1714" mass="191003" checksum="458C7CA9DCC74F8B" modified="2014-09-03" version="1">MGFLSGVLGAVKNENEVITYDNNLQTKLKDVLDTLNTKIGHGRAGLAVSVAAVKGWLEGYEGEVGKKTKAVTDNITHLMNDLTRHKDNIDNEKMSDLSTQIQNWTARAEQYRLHVVAAEKDMKNLDSKLLGKLTPNIQMLFQAMETFKEAAKVEGMKEMYDLADAKMDYIKHYVTKQAGKRSEEIENYLKDRVGKLYIKLDNMKQNEFNMLLLSLDKDAAVAFNKVNYNMNSILNRYGKDIVKEVEGILAAAGRLKGEIQAEKEKLKMQVKQLGLRIEFFRGIFGGVKAEVVEDQSGIEHTLKLTDAIKGLTQQVVQNVQGYVSATLPSELQAALREMTDGIAKAEKSVAKEDGHLDKIANKAESYAKSFEGEAFGSIVEEWIYEILQNVMVKHWFDAYASNNNGRLTESYHSAVKTGLSSEQFRKLAGVIKMQLGEQIGRAKIKALGKSNIKDNIEAVKNGIMSFVQAVDEKLTPKEITTFVSNIVQAIEREMKGSTSQDSQSHNINDAVASAITALRAKASQAAKVLQSFTSTESSYHLGDQVLSAITDVTKLGDKMSKAVYESGSGLGKLGKEIDKALAETTTAASNVKSKLSDLLKMTASKTIDKLNRVVDKIVGPATDAENTLTTIRDVLVTLQTDPNERGVTTGVEGGKSHLEIQSCNLHNKISSFLTTTVGQSDSNTGTVYNDLKAVRDDVTELGKKMKNVKCKVADVGKELDDCIHKTKYVFEKAIMKVRYVMQTLRKEMVEKITESFHGMENTVKDLYAKRKTQEVEALQSIINKQLSEIIKTMELDKVAGLKGLLTRLAYNFVNNVTNIKDVQPASQTGAAATSDTYLPKGCLLVQAVKHLITGVNAFSDSLSSQAEILSVVDRVTPVTNSLKGLLKRIEKSEHHDHKVVEKRDEFEEVLAKFKPETMDDAPKKVLTPLKKGFGKFVDELKKQYVNKYSGKKIVWTEITDPKKGEGPTADATNCAKAFLTLIPVMCHDVSDLRSKCVANWKTLLTNLRGKNNSLGACLQEAGYKVSKSDTVHNGELRNTMNGQNVHEKLKRTIPVARDLDNVNTWILNEYNRKHGDENKITLLDLFDYLHYCLKGYYEVCHLGTLSSKKHPRSIYDMLQWLSGLSYNPVHQELALNGFSDLFEKPEKDESDAELSLSDKDPDTLEAYPEDVTATKLSNGLRDVCAYSETVLVAIQGYGHAGGRYACEFNSNADSFVYPADPAKCLEILADVLLRVYEQLCFLLVQCSREYEANSWRDCYYGHGVGGSSWTCNTKQCGNQIGDQTCNQTVNQNASQMANQNGDQKDDQQPKCGLKSPLQSFLEDGLPGFIPHTFDKVGCKLECTVSKHRGLPCKTPMGFADISNVASHTKQGAHLTKVLYDFCGHMDSPLVKLCSNLVCLLNRPPQTLSDMYAFYYNLLHDWHGKSRGAIDVRKHKMTAFNDAVTRANFGVPYPELNVNSIITDHKSHNHTTGDLLCLYSCNSTSSLTATCGRYLQPFGMNTWTVFSENHADKYLSWIVYITEVFYNLLEQLLKECCQNCTSAQSRCNGKVCPKTCQVKYTNNETKSQPVGRDHHTDDCKSIAYCPFTRPTLCKYGFVFKSLSNMSGSSGESTKRTCKDLCHALQNVLLKGKVLGEFTHVTIPEFLWNIRQKFFWLNVTLWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARIGRVSKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE6</accession>
    <name>A0A061DDE6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein transport protein sec61, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0301200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768401.1">
        <property type="nucleotide sequence ID" value="XM_012912947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDE6"/>
    <dbReference type="STRING" id="5866.A0A061DDE6"/>
    <dbReference type="GeneID" id="24564756"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301200"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="476" mass="52960" checksum="3FEBB5679AA1F4C7" modified="2014-09-03" version="1">MAKGFRFLNLIKPIMPILPEIRTPTRKVPFKEMLMWTGMSLFVFLVCCQIPIYGAVTNKSSDPFYWMRVILASNRGTLMELGISPIVTSSMVMQLLAGSKIIDVDQSLKEDRDLYQAAEKLFGLLVTLGEAVAYVVSGMYGPVSEIGVFKSTIIILQLFMAGVVVILFDEMLQKGYGLGSGISLFIATNICETILWKAFSPTTISTDKGTEFEGALISLFYCFFTKGNKLSAFQDAFYRSHAPNVTNLLATALIFTIVIYLQGFRVDLPIKHQNMRGQRSTYPIKLFYTSNIPIILQTALVSNLYFFSQLIYRRFKNNLFANILGQWQETEHGSSVPVGGIAYYISPPINFKEIINDPVHTLVYITFVLVSCAVFSKTWIEISGSSARDVARQLRDQRIGMVGHRDSPPSLTKVFGRYIPTAAAFGGMCIGALTILADFLGALGSGTGILLAVTIIYQYHEMMVKEQERSGSLMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH8</accession>
    <name>A0A061DDH8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769605.1">
        <property type="nucleotide sequence ID" value="XM_012914151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH8"/>
    <dbReference type="GeneID" id="24565960"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313215"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313215"/>
    <dbReference type="OMA" id="NRKYQFD"/>
    <dbReference type="OrthoDB" id="360787at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="215" mass="24821" checksum="35C8C598DCDFF2FD" modified="2014-09-03" version="1">MNPDLQGAPRKRGGRRYQFDPVSVSASYPLVAEHVRKRVFVDRTALKRQHAESVKARRALFERLSQLEREFVRPQSLDEIALRATSLNEQLAIQRETECALRSLLCVVQKARRAAASEESGLFSAKPSTTWEEQRSERAALEALREKRATKFLSQLMVRSRAEMERRRLVMEDAVRRKQLRDMEEHAEEQETLLGSDRKLLASGVYRGQMKPQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDL4</accession>
    <name>A0A061DDL4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769710.1">
        <property type="nucleotide sequence ID" value="XM_012914256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDL4"/>
    <dbReference type="STRING" id="5866.A0A061DDL4"/>
    <dbReference type="GeneID" id="24566065"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400160"/>
    <dbReference type="OMA" id="WPLFIRE"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="17410" checksum="9A1F78500ACB5C05" modified="2014-09-03" version="1">MLCRSYQEQVSKWPFNPLTRVIAWLEEQRDDKVIGDFGCGEAMIAQRFHDRTVHSFDLIAGNPLITACNMTKVPLNDNTLDICVFCLSLMGQDWPLFVVEATRCLKEGGVIKIVEVRSRLTSIEEFEKFLESLGYKKDNAVSTDVRFLFVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP0</accession>
    <name>A0A061DDP0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA recognition motif domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768616.1">
        <property type="nucleotide sequence ID" value="XM_012913162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP0"/>
    <dbReference type="STRING" id="5866.A0A061DDP0"/>
    <dbReference type="GeneID" id="24564971"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303340"/>
    <dbReference type="OMA" id="NVKVDWC"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="98" mass="10814" checksum="AFD039EBAA913962" modified="2014-09-03" version="1">MSSEEQPVKSVGGWIVMVTGVHAEAQEEDVRDAFEGFGQITSVHLNLDRRSGYAKGYALLEFVEEEDARKAVENMNGQQLLGQEVAVSWVFKKAPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS1</accession>
    <name>A0A061DDS1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">-30S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0401360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769830.1">
        <property type="nucleotide sequence ID" value="XM_012914376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS1"/>
    <dbReference type="STRING" id="5866.A0A061DDS1"/>
    <dbReference type="GeneID" id="24566185"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401360"/>
    <dbReference type="OMA" id="HYCTSHW"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="554"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="781"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="811" mass="91057" checksum="E106938C938A85A1" modified="2014-09-03" version="1">MLYVSSFLLAARGHVQRVLRRKQAPFHQRYDRLPGDQRERVAAMLSDVRYEKCSVARELSDVHQQLASLFNADEARQLLDPSSSSGNATADAAPDTRADINEAYRIHRILRPHAPNFFEEQSFIHLKQRMDNLMQDHKSEDFKELVPADVALDVVALPDPLFSDEGYAVAMSALMDSLIDDVRRLCRALGLDVGTGDSRDPYDRLADFLALKRDGSNVDHWSANVWPKLKPLMAAEFESISEEDVGNWLTSHLERVAHNRALVNRAESSEWYRVKLIVRYDIKRDLPYDGLPYPDALLDERRTGYPIDRAGAYLFGMLQLFAPSSVEGVTKAMLDEYVDALRNIGLKDWFGLRGVDISSVFFGHDAANELPGNTSGSGTQGSFPHKKVTRPMAESCIRIINLFATGNEHVFDAEHWSPASVFKRLSVPGDTADGSGSSPAGNVATPSSGVDSNSSVQTKSVATALSTGDIEDLVGDYIRRVNRVASGQVVREYNRVFDRMVKEELEFQANVGAGTVTDKGIEYKVPAGAQFDAKRNYYVRTREGVDPTLKLENLRSCVLERRRMRTMTKEGRVYFLRVVVAVGDGRGYFGTGVGFGNDLGTARASAVQQALRGMYFIDFDQKEPLTTPVLGQEYGCRVYITPRKMGAGIKTNRKYLPLAYLAGLDNCKLTFHGRSSWITRAKALRKALEQIYSRRTMCNATGMRYVYVGSPGDHTVHWPDKWFIPIAKEYQSKVQQLKNLKRVHFRRHAHRVVMPEEVAPEVPSYARHKFRSPLEIAEQERKHAQYISTTVPKVPPPRGNKGLESSVEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE72</accession>
    <name>A0A061DE72_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769071.1">
        <property type="nucleotide sequence ID" value="XM_012913617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE72"/>
    <dbReference type="GeneID" id="24565426"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307890"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="187" mass="20672" checksum="FE5F9BE6ADC95084" modified="2014-09-03" version="1">MSLYPGKPCTRCRNNCKSSYVCNCCPWCCEECNKGFDRCYECFTLVFMRKKGTHAYVCDNFKCAIKCKGKELKCECKCCKEKCASPGACQAPPPPPPPPIVAPSGVESVIVGQPQLSALSTEEHSEDDPDDDASQPFRPDPQAIAAVIVGIIVAIILLDLCIFRFPVGRNIRDFVVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE88</accession>
    <name>A0A061DE88_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIE beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770255.1">
        <property type="nucleotide sequence ID" value="XM_012914801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE88"/>
    <dbReference type="STRING" id="5866.A0A061DE88"/>
    <dbReference type="GeneID" id="24566610"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405540"/>
    <dbReference type="OMA" id="RRIHNTH"/>
    <dbReference type="OrthoDB" id="363990at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="35011" checksum="6EC034945A5E08A8" modified="2014-09-03" version="1">MSFISATSSFNLHLQPRKQQESEASTPQSTPQFSTRASNITYKGDSCPIIYVTHKILRILTQHNRALHTLEVEKALRSLGFMGVDICTNKELFESLQKVKRIEFDVARKRLLYKNPFESVTSPDTLLEYINKNCAIKGMRINEELMNTSPNMVEWLDEILKQRKVRAIRCTSSNLKGKRKCRYAATPNQCTIYSSSKCNECINNVRDILLFPLGKESCEQDRFKLDHDIKTLWDSVTMPPVDQLLKDYNVSQVEYTYVAPQSSRRRRGERKQGKNAGVKMRRIYNTHLFTAQELSAGISNTTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEC8</accession>
    <name>A0A061DEC8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0309580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769241.1">
        <property type="nucleotide sequence ID" value="XM_012913787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEC8"/>
    <dbReference type="STRING" id="5866.A0A061DEC8"/>
    <dbReference type="GeneID" id="24565596"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309580"/>
    <dbReference type="OMA" id="GSFLYFH"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="184"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="389" mass="43410" checksum="A6DCBC3172D3AF62" modified="2014-09-03" version="1">MDALSLDISQAVEASVTPSPAQSSQRSSPRRMATYTSFLPRRTTSVPADNDTDPLICSQDRNLSSARVRAKSASAVKPTSSGTSFIHCLPVVVVVASLATAYTIFVFYHLKPAIEDDVSHLGVLSNKTVAILLSTSISCLMFLLNYILCATVDPGRVPETLDWCMYPGSEKRAPPTVCETTKSGDRRSCKWCSVYKPDRAHHCSTCGRCVLKMDHHCLWVNNCIGWANHKFFFLSVFYAVVLSGLVSTFSYPTVRHVMRNPVVPTKQYIALIVGEAISILAFVLCSIFLIFHIWLMCEAYTTLDICEKGTYSCMWLDRSIWSGTLYENISCVLGRNPLFWLLPIDDRIGDGLTFTPHITSDDTDESYDENSTFIKMARETKQFEPILDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEH8</accession>
    <name>A0A061DEH8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769491.1">
        <property type="nucleotide sequence ID" value="XM_012914037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEH8"/>
    <dbReference type="GeneID" id="24565846"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312080"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="101" mass="11597" checksum="164E582AAE6BA414" modified="2014-09-03" version="1">MVKVQDAYGRETELSLNCSCNGDGTGKVGLASVLLLTFFTYYLVTHLTPDFRKWHDYFSNILGARKLRFIPRSELDAPQITHITEEMDINPYSFFPSKDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEM5</accession>
    <name>A0A061DEM5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0400320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769726.1">
        <property type="nucleotide sequence ID" value="XM_012914272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEM5"/>
    <dbReference type="STRING" id="5866.A0A061DEM5"/>
    <dbReference type="GeneID" id="24566081"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400320"/>
    <dbReference type="OMA" id="AKWPPPW"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834:SF6">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82653">
        <property type="entry name" value="Probable GTPase Der, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GTPase Der C-terminal KH-domain-like" evidence="4">
        <location>
            <begin position="507"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="609" mass="68511" checksum="EB5A1E04CFB106D9" modified="2014-09-03" version="1">MKSVVSDHPGTTRNAKHGQFFIKGKRISLIDTGGIDSLVYPFANRIQKTNGSHSLSRIEDDAVRAIKMSDMVLLVLDGQEGLTPLDTKIARKLRLWSKDTPRGFKINLVVNKLDREGSKDYYEALSTCLSDCYSLEMGEPVFVSAVERTGIKSLLDLISEALNIRDANRNLNLEDMALMANHHIDNERSAYNGVGDMSMTDADIDRSMRVFSPVSSSFKPHERWMRLLNSVCDNVPFTIADEGDFVVPPVLSPGEKIAQMYISKSANNRMFVDQSEGDTTVENSYNDIESTQPKIEETSSTMLPLRVVLLGSVASCQDTLARLLADSKINSTNVPEFIGDTLSPNWHQYYVEWGRDNCKLPITQPVELYSAAALNLGGSLGRVASMQTLALVRKADIIIMCVQNTDERHAWKVHLTKKECAWVSRIIRSHKPMVLVVPAQQPPKRKMELDLSSTGHEFDGIPILSLPMINAGLDNTTELTTPDVQHTALRRLRNEVLALARRSRQVIETSVLNNWLRKFLAKWPPPWHDGAKVNVKFAAQVRGNPPTFIMWSNVYGVFPQHYMRQIKRAISDEFGFKGVPLKFILRTTAEPKSTGRRHNLSWKRKLHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEM7</accession>
    <name>A0A061DEM7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769736.1">
        <property type="nucleotide sequence ID" value="XM_012914282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEM7"/>
    <dbReference type="GeneID" id="24566091"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400420"/>
    <dbReference type="OMA" id="HIARSMS"/>
    <dbReference type="OrthoDB" id="365692at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="266" mass="30124" checksum="1BE157DB7EA2D65E" modified="2014-09-03" version="1">MREDERFVSLRGCRRPSAHTVTTAEVCVLWASTIVSKRGFQSDELLHIARNFARSEFSHFAVQVVIPSPFCMCRIYSNGRVVIMGNLTEGQVEKELSRVVYKLRYRTKWKVSTLRDRITHGNGLQWCYVVNNNVLPVKTVLQSVKVDQLYCRVAFDGPIDLRLLLQRGLSAKQNITSISNACVRLQIDLPEPPENSTGPAESDPTTSVWDAGLELERELEAELAHLRRQDKRFATCVVYHSGKVAILGCCNHDEVRFTFDALATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DER6</accession>
    <name>A0A061DER6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">-N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769931.1">
        <property type="nucleotide sequence ID" value="XM_012914477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DER6"/>
    <dbReference type="STRING" id="5866.A0A061DER6"/>
    <dbReference type="GeneID" id="24566286"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402340"/>
    <dbReference type="OMA" id="QHWTRRT"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="357" mass="40190" checksum="CF416D10F87E65D5" modified="2014-09-03" version="1">MRLLPWFLNPWHVRGDVSGFALPRQRGALLEKLSIALCRKIPGLAGLLGVRLGSWPNEVPGAPIEITRVDEDRSSLTFLGHRTVYIQTGGAAFLTDPLFSRRLYFPLFGLRRVTNRVIKFWKCPMPDFVLLSNNAYGCVDSFSMRRLGDAGAALVLGGMNVSRYVMFFFRGYTYPLRWYETVNFGSVEVTFLPSCSNSGRRWYNRDLLLWGSFFIRSATKSVYYAGRTAYGSHFREIREFLCRQGHSIDVAILPLGPVFRRSPELTPEQAVTAHMELGARKTLVVAHDTFPLGVEGYGELVERLYRRISEVDPSLREKFIVLREGEAADITDLEGTCTDDRNGAANAPGEVGSQQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEY2</accession>
    <name>A0A061DEY2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0405600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770261.1">
        <property type="nucleotide sequence ID" value="XM_012914807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEY2"/>
    <dbReference type="STRING" id="5866.A0A061DEY2"/>
    <dbReference type="GeneID" id="24566616"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405600"/>
    <dbReference type="OMA" id="HESEMRY"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044587">
        <property type="entry name" value="HSP21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46733">
        <property type="entry name" value="26.5 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46733:SF4">
        <property type="entry name" value="HEAT SHOCK PROTEIN 21, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="213"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR98075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="313" mass="36069" checksum="120238125F3F1656" modified="2014-09-03" version="1">MSDWVVSKEKRVPIDHISRRRSFPVRPPPLRIYNPIKVIGFDGSLRVPKYRFWNPFMPENVLKAAYVPVVAHPFGNRTKTQLPRSDNGISSIHNLQSVFDAVDRQMDAWNRWIFGDPVRASHTAGAYRDAHSLSDFMDFGRSLFDSWDDQVESVNDNHAYERDHPSRYRDSVSVASEDLRNYRIATDRANRDFQSIQSRLGYQDGNVDDERHNDMLPVWRPASGANKSDDRKYYKMTFHLPAFNEEDVKIAIREGVLTVRAEANEVAHDENRSVARRSQRFHHTVSLPDDAEARLAKAKFANGTLTVKIPVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYL6</accession>
    <name>A0A061CYL6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765917.1">
        <property type="nucleotide sequence ID" value="XM_012910463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYL6"/>
    <dbReference type="GeneID" id="24562272"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100600"/>
    <dbReference type="OMA" id="ANFERAC"/>
    <dbReference type="OrthoDB" id="364491at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="202" mass="22632" checksum="78DC8E9FA0A775B3" modified="2014-09-03" version="1">MWNRARVKTSSLQALAQLSRLSRRYKIEKVQRLSANFERACWRSVRTAEERAYHQKYAFLRHCVDTINFRKADDRSRRVPLPNTAAALASQFTGSNGPQLQKRVQSHIDELTAGLPSCLSEADASLVTADGSHAAQIVARCRAHGMTTPECERAVCALSEIARLRTLHARLATYTTHSEGVEDRCYTKRELELVVSGESGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYN0</accession>
    <name>A0A061CYN0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765927.1">
        <property type="nucleotide sequence ID" value="XM_012910473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYN0"/>
    <dbReference type="GeneID" id="24562282"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100700"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="383" mass="43450" checksum="986F53FEDD3262C6" modified="2014-09-03" version="1">MAYQRGNRKPLLSEGQEKPNNSATYVLKSLYTDGEDHRLREIQEALKRLKKLMLRTDALHSDILSDLRSYVTLCLNNQTGHSPSCNGNNCKQQLCCLFPQLQRSCLGARLANGQIIKTSKRWHNLTNQCNMAYFAFTDAPRNVKEGIDWLIALKGTDPENNIKAIGEAIHKFLADKPVGKMKIPALERIKCISKNFLQQESIKDCPLVNDMLRKFNKAWDKSAGKWLKRLFRIYESDYKNVIQSKGLTAETISNNLGKVVYACEEFLRGIKVPGQYRSAYSSEAMFYAACAKFPEACAVVVVGIAPMLYVGLQSLSDASVDAFLRWPPFTAYNRMQEVLKAVGYVEPGCRRGMKASHILSAFRGFNLRIFKNIYDFAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ10</accession>
    <name>A0A061CZ10_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765874.1">
        <property type="nucleotide sequence ID" value="XM_012910420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ10"/>
    <dbReference type="GeneID" id="24562229"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="187" mass="21051" checksum="E4AC4989ECE77A9C" modified="2014-09-03" version="1">MGRVLYFGKPCTRCHNECKHSQVCHCCPWCCEQCNKGWESCEICYAYSELRRKGRSKDPYKCEDSKCEKKCAGKVDKCKCTCCQRKCKEQAEICKAPALPPPQPSSASSDDQSQAAKLELSPRDKDQTQDHDSPPHSPPSPQAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZE1</accession>
    <name>A0A061CZE1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase, AAA family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0101120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765969.1">
        <property type="nucleotide sequence ID" value="XM_012910515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZE1"/>
    <dbReference type="STRING" id="5866.A0A061CZE1"/>
    <dbReference type="GeneID" id="24562324"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101120"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="290"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="681"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="946" mass="103140" checksum="034DF26559C97621" modified="2014-09-03" version="1">MASFELAVTFLARKLQFSAHECGQNVIVAPAQTFKKYRIEHGSTVLLSDTSGGRVVCAQLRNAVEHGMEYSFLKAPKMLASEELILSLGAAANTPITLRLSPCEQVPVAKSVTMTYMEHFDSKLACWKVPSTQEEDAIDASGGKSGAAFHRKYMDWSHSDSAGDNAFPTARWWYSFLKGDMNRMAQMSVLGGAFAQGNVVALNLKGVLARFKVADIANDDKKRGGRVGRVTESTQLALKLPRNERLSQPTRALQQTQRLEGLREPLDTLRKHVVYPLVYSEKYAAMGIFPPTGVILHGPPGCGKTMIAKAMREGFGELFGIAEHVDVEVKLVQSSDLISSVVARTEENIADLFRSCEKAAREKPCICFIDEIDVLCRKRDGSTEFNMRNVTTFLNHMDGVGSQTNAHSRGRNYVIIGATNDVDSMDAALRRPGRFDLEIEVGVPNSADRLAILKSMLKDIHHNLEEKDILHVNDYCQAFVGADLKQLVANASWARLNKTQNQRGSTESVDGSDDGGSKTAGDGVDGGSKTAGDDGVDGGGKAGGDAVDVGSKAGGDAVDVGSKAGDDGVDGGSKAGDDGVDGGSKTAGDGAGDSDDSGAVRDEPLQEDLKGAEVPHCVTLEDFKEALNITRPSALRELYVQIANVRWDDIGGYDDVKRILKECVEYPRTYSEAYEKMRVQTPRGVLLYGPPGCSKTLMAKAVATESHMNFISVKGPELFSKWVGESERAIRQLFRRARTNAPCVIFFDEMDSISFSRELSDSGGVSSRVLSQLLNEMDGINSLKQVLVIGATNRPDLMDAALLRPGRLDRLVYIPLPDGEARKRIFSIYLKRLPTDGFDIERQAEEFAKCTEGYSGAEITLVCRESAMAALRELISRDAEAKAASGSRTDDKRDDSTLENAFGNLKVSKIVPVSVRHVRDAIARVKPRTKPETIRFYEQYKARNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZJ8</accession>
    <name>A0A061CZJ8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6827 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766237.1">
        <property type="nucleotide sequence ID" value="XM_012910783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZJ8"/>
    <dbReference type="GeneID" id="24562592"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103650"/>
    <dbReference type="OMA" id="HRIELYE"/>
    <dbReference type="OrthoDB" id="361874at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049230">
        <property type="entry name" value="DUF6827"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20715">
        <property type="entry name" value="DUF6827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6827" evidence="1">
        <location>
            <begin position="121"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="273" mass="31056" checksum="CAD6E9107E53D97D" modified="2014-09-03" version="1">MGRRGHSRHANSQKTMSLNAWCRAIFSGNGLHAGRTALLGSARPYAPRTVCPGQAAARFHGHAHHEPPHFAYRGDGLPPIACEQIQQMVHMNERMAQGKLASMRPSAAPLREAECNVEGHRIELYEDLKELHDTVMAANWHDSILLTMNADLWDGTLARLKRMAEDVSDMQVQIMLSKTLEIFDALYKVEDVQDHIFELIEELPHFGGKPATETPLAAGNIDKHIKHVLERYAQLKQEHPRYTAKIQDSVGYSLAILRQRYTFSWPEEHKYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZM1</accession>
    <name>A0A061CZM1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA processing ribonucleoprotein binding region-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0103840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766257.1">
        <property type="nucleotide sequence ID" value="XM_012910803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZM1"/>
    <dbReference type="STRING" id="5866.A0A061CZM1"/>
    <dbReference type="GeneID" id="24562612"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103840"/>
    <dbReference type="OMA" id="IGNGPMD"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="229"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="496" mass="53804" checksum="91140ACC3610BB1A" modified="2014-09-03" version="1">MVFSNTAQLYRAVQASLVDSFLDDLDDLEREEEAAADVAPSGGSAESKVYDSDEDAPIIDAVAEYFSAEGSAGSSYSAMVTDPVMNGLVERVKALTLESAVDPGELSLIEDCNKAVLEIDNEIINIYNYVRDIYSKRFPKLESIVYSPLDYISVVKRAQNEMDFTKVVLSDLLPNTMIMAVTVAATTSSGSVLSSNVLKEVLIACNDGLLLAEFRNDILVYLESRMTLLAPNVSAIIGSALAARLITQAGGLTTLAKMPSQNIMLVGGSRKGVVVPGVIHSCEIIQNAEPSTRNRAVKLVSGKLSLAAKIDMFKESKDGSMGVHYRNMIIQALQKAQEPPPAPTKKSLPVPDERKSTKRGGRRLRKAKERLATSEFRKYANRLKFGEEAEDEYGLESGSGLGMIGKYTGYGRLRLQHKQTKVQLPKKRQVAMQSSGATNGMSSSLVFTPLQGRPTFVTNKRAAGIELCNPDAAKPAVKKQNSILDNTSGFFKVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D084</accession>
    <name>A0A061D084_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766427.1">
        <property type="nucleotide sequence ID" value="XM_012910973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D084"/>
    <dbReference type="GeneID" id="24562782"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105500"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="104" mass="12391" checksum="39556754F4CACD4B" modified="2014-09-03" version="1">MVEIYINRQRSEELELQLTADWNLNLPKDLSLCEDISKTIERAISKLRESNTYMRSVSESGEDVELEKYIKENEMVIRRKIYQLNQVKTHMDKLRPDMDKAENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Z1</accession>
    <name>A0A061D0Z1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0107790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766667.1">
        <property type="nucleotide sequence ID" value="XM_012911213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Z1"/>
    <dbReference type="STRING" id="5866.A0A061D0Z1"/>
    <dbReference type="GeneID" id="24563022"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107790"/>
    <dbReference type="OMA" id="NGWLDFH"/>
    <dbReference type="OrthoDB" id="364524at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="349" mass="38316" checksum="FB1164B0473A507E" modified="2014-09-03" version="1">MLHTAVLSRALAERCRCVLTQTRTKKYLPFYANTRKNQAKRGKQPKSEQRSDGPATAAEADNTRHNLVSRLATPDEALEVLRSLRCAAINADVAAEQYRFRLWTRVDVKRTALRGMAVLPHPVGPKPRVVAICEEEEATLALECGAAYAGLDSILERIAGGWTNFDTCVTTTIHMPKLVKVARILGPKKLMPNMKEGTLCSNLLEAVRRLSSSNALQFRATPIDDAEFDTIQAMVSPRKKLDFEVDNVAALEVPIAQGGATPQVVVENAKHFVVEVMKQRPPATAKVTTNEFKWPPVRKTVNSILEDAFSTLGTTHKADNQFIVGGAFGLARQGQSMSTPIIFDTGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D156</accession>
    <name>A0A061D156_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0106720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. May regulate protein translation in response to amino acid starvation. May regulate protein at various stages of parasite development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766549.1">
        <property type="nucleotide sequence ID" value="XM_012911095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D156"/>
    <dbReference type="STRING" id="5866.A0A061D156"/>
    <dbReference type="GeneID" id="24562904"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106720"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="332" mass="37359" checksum="858031C0EF602FC3" modified="2014-09-03" version="1">MSGNKSVLGDCRFYEQKFPNPGDLLMVKVNRIEAQGVYVSLLEYDEREGLILLSELSKRRYRSINKLVKVGRHEVVLVLRVDPVKGYIDLSKRRVSPEDIMKCEEKFSKAKKVHQTVRHIAQKHNISVEELNRVCIWPLYQRYPSALDALKEAAMNNGAIFKGLPIATEVIDSLIADIQLRLTPQALKLRCMIDVWCFGPDGVEAVKNALSCAKGTDEIKISVKLIAPPQYEVVTSCHDKEKGIDIMTRALEEISETIHSFDGGEFKQRCEITVMGDEDERHLESLLEGQESSDEDEDDSDDSEEEDEGMGRVDESMLPPDAVENGGDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D182</accession>
    <name>A0A061D182_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LSM domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0101860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766043.1">
        <property type="nucleotide sequence ID" value="XM_012910589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D182"/>
    <dbReference type="STRING" id="5866.A0A061D182"/>
    <dbReference type="GeneID" id="24562398"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101860"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR93857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="84" mass="9274" checksum="8EE17B1599BB3E17" modified="2014-09-03" version="1">MDVIRVNLDEHVYLKCKGGREIVGKLNAYDEHCNVLLSDAKETITTVDVDAATKKGVTKVTTRESETVFVRGDSLILLSHARDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1A5</accession>
    <name>A0A061D1A5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766777.1">
        <property type="nucleotide sequence ID" value="XM_012911323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1A5"/>
    <dbReference type="GeneID" id="24563132"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108890"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="129" mass="14034" checksum="C8E3108922892701" modified="2014-09-03" version="1">MGALGDVGTWLPQQKANGSIGLGYGHWFVKMGSGQSLGITPCECETGQTCKRQSCQQCKYWYCLCDCCGRKLGIYIGVAFAGAIGFFGLFILVLYICSKVYKMSFGTVIDQIDHALTGYQPSTSKCNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1B9</accession>
    <name>A0A061D1B9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Papain family cysteine protease containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0102310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766088.1">
        <property type="nucleotide sequence ID" value="XM_012910634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1B9"/>
    <dbReference type="STRING" id="5866.A0A061D1B9"/>
    <dbReference type="GeneID" id="24562443"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102310"/>
    <dbReference type="OMA" id="EKGNHWI"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="215"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="423" mass="47217" checksum="19082CAE958C02E2" modified="2014-09-03" version="1">MAGKVEVLDDVVSRAETAEDLLKNGSGGKPEPWHSRLRAFFRRRGKCYYALLAALVFALCFTAVAVIGGDSQYAAQERAVREALVRLKFENHGTVEGVTDEDPAYIVCRALGASTRTLNPERDAEIYVQYNDFNRQYDRRHTSVMEKARRFGVFHANVHTIDAFNAMENRTFEMGVNRFADMTAEEFMALQGSRVDTPQYERGGVAMALDGTVDIADIDLRRDGIMTPVKDQGACGSCWAFATIAVVESYFKKYRSLDLDLSEQQLVDCVKECHGCQYGDSYHAYEYVTANGCYTRASYPYVAEQGQCMTPAGHPRYRLYEFGFTESPDLVQLLKAHGPLTVYVAVTPMWQFYKSGVLNYCGETVNHAVVLAGAGQADKEAFWLIKNSWGTSWGEEGYVRLARGSSTLKDECGLSNVAMFAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1M7</accession>
    <name>A0A061D1M7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3a, subunit 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0103460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766218.1">
        <property type="nucleotide sequence ID" value="XM_012910764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1M7"/>
    <dbReference type="STRING" id="5866.A0A061D1M7"/>
    <dbReference type="GeneID" id="24562573"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103460"/>
    <dbReference type="OMA" id="EFWIQIM"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="238" mass="27236" checksum="77FE634FA1322AB0" modified="2014-09-03" version="1">MDYQNRVGHKTGGGGPASAQDLAAHNRDRLRRLALETFDLGKDPYFQKNHLGQLECRLCLTIHASDASYLSHTQGRKHQMNLARRAAKEDRNNFSMPLPKPVGMPRTSSVKIGRPGYRITKMHDPETKQYGLLFELEYPDIEGKPRYRLMSAFEQRMERPPDPAFQFLLFAAQPYETIAFKVPNLEVDDSPGKLYVNWEETLKLYVLQIQFRPARTAKPLPALPHRPSVYQGVGPKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D295</accession>
    <name>A0A061D295_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0200330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767062.1">
        <property type="nucleotide sequence ID" value="XM_012911608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D295"/>
    <dbReference type="STRING" id="5866.A0A061D295"/>
    <dbReference type="GeneID" id="24563417"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200330"/>
    <dbReference type="OMA" id="MLWFIGQ"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="435" mass="49729" checksum="80EB24B3A8CA57E1" modified="2014-09-03" version="1">MDDALRKLLTGPESNPFGQIVVGVLSCRWLVYILAVVLRIGLIGYSCYHDWFCKCLIVWCNGLVEVKFTDVDYRVFTDAARLLLSGQSPYLRHTYRYTPLLALLMVPNVVICDLFGKAFFCIFDVLTAYMLEKCATTGNSLVPSIWLFNPFVVVISSRGNADCVICFLVVAALYYIKQEKIITSAIFFGLAVHFKLYPVVYFLPFILHLSHASAAREALTGNWLVKSIRTVKNGLNLNQLKFAAVSFAVFASTSLVCYYFCGFDFVYETYLYHYIRKDHRHNFSVYFNYMYHMVDSDSELNPVLSFIPQMVCVFVYGLLGFWDLELSMFLQTLSFVALNKVVTCQYYLWWMCLLPLVLSKLSFERKAVMIQGAAIVSFVGSNLLWLFFAYCLEMLGYNTFAMLLCSSVFFVFAQMAIGWAFLETKAPEGVQKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D297</accession>
    <name>A0A061D297_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766919.1">
        <property type="nucleotide sequence ID" value="XM_012911465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D297"/>
    <dbReference type="GeneID" id="24563274"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110310"/>
    <dbReference type="OMA" id="GEHDQAP"/>
    <dbReference type="OrthoDB" id="366458at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="787" mass="86103" checksum="169F7C202B1FCA28" modified="2014-09-03" version="1">MTDAPFSSAALRRAETELWQCDDGASRSDFCNTVSGMSITATRVVRSGDVRHTYAPPSALSPSGKAVGQACSPECTSGAQSLQPPLVCHVGERSSSDGIPRVPTLDLALLHARPSASISSLGEHDQAPPPQVKPQEHKADIVGQLNAIQSQLERKLSTVRIEYQKKLSESAMVGFARRRSARMSSLQTDESISLHSESSFREKVDQRPESRGYSGAHNVAAIVNTRGRQRNAPPPRMAAGGTPRRPSGEAPNQDKAEIGAPITRYATFSTAKCGSRMPSRFAPPDWNALIRHYVKKDTNGSPKQHNKSETRQAPPLPPAQPDNSLPSAALTRPPEARDARMPPPLRFNPLHRKNENAYDVDLVNKLCRRAPTNPVGPATLGRTNTTTIGKFEGARDSALNDARRSNTAALLLCGAGKDKEDANISLVTFPPTSPTLSEQDLSSKTVTDDGWVRSPIARAYSYVDWIFQGTGENEESRSDEQRVSQPPSPQVAGGDSALDKRYPSMRSLRYPDHVEGAMPRPTAPRPRVEAGTDTGNEGAMRRQTTAPLRRRDTYTVNTNQIREKIRALASHVSEPPSDADDDDTSYQVVSVSGSDLDRASGQYGPPEQQQTFSLSENVVERNVDAGLLTHLPTMSGNCVKGIAGYSMEQLYRLSRVNSKCALLRHGEPDAPAEMGNTSGFGHPSSLRTSVTPWFKNPLNEKVHRERARSAKHAAFIPNAQQVEDIADADLKNLLDQIATYRLDLEEPERHGVMDPFYEYEKMMQNKTLASSDWARYGRPAGRQTPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2R1</accession>
    <name>A0A061D2R1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular matrix-binding ebh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767079.1">
        <property type="nucleotide sequence ID" value="XM_012911625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563434"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200500"/>
    <dbReference type="OrthoDB" id="367023at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1334" mass="148253" checksum="808D62230C4F1AD8" modified="2014-09-03" version="1">MKEGRDNVERVAKGLTFVSDDLEKWREAAHTVLSTAVDNAVEVHKALDPARNSSTLGTEIHKIDTARQGIVDANKELESQVKSLNKWIQDAEDIRQKAETKAREAYDKLSVHEELSKNVKKIMEAKEKIVGVNKSVNTHIGSLKQWNEKAKEVLDGAVTKAQEVHNRLKDNVGLKVEEIKKSNEAIKEANAKLGDEVANLGNWNTAARKVIEMADKKCDEILKRVDKNHNQPKDVEIYKQAKHLQDHGKKLLKAAKDAKQKVESKVKEALDAVKDMDADLKKDLKVVKDKIKEGIKDVMSEFKVGDLGKEVEKDLKQLRERIVKLSENGKADGLFRGQLKALDQETQSVKQRINKIKSETDKQLEDQFRTKIKEPLDVKVKAVEEAIAKVYERFNSQDGSVSSENKKKLQKIFEHIRGQVADIKGMKGGNTGLDGIVANVKGLYNAFVQGNGKGVDARVDGWLGSILGINENQRVTHTDGMKAVTSWIKEYNGKARRLEDALKIVKDQIKGALSSQIKAGQRVITQQDVEDNIVKNLTKVKEACRAFVEELDKKLTDKQITQFANPIVSTIQSRLRPGQRLPAVNDEKLTAAVRAALIALCSCVKQVAAEVDYLGISLFGTIIDETKQAVDDRHGKLARTTNTGTPGKANPDPGTAQAVDKAIEGVKEMVDNTIKEKFENEVKKPVEEAVNGLDTAVQAYDKKAREQVKDAAKGAIDKAANVISDSTGKIELGGNNKLMKNFSNAHKEITTNLKPKLEKLLNDHIGRDDTRDGKREQIKLSRDFKRYDDHVSIGSLTDYVYGRLSLAIEKVRDEGLTDINKHVGKRAGDRTEEIDITGSCSKVEKELKDIVDLLTHNDKIILDYGDITNRGVKTLLTELDDGLTKPVPGVFDKGLETITKVIGDLQRDTFDTKSKTIEEAAAEIRKEVEVLKKKLLSDGGNDDVINALKGLKDTGMSSGTWNGKGGSPIDGLKKIESELERYNEVLGKQPGIIGDAVYGIRDALARIKIKLNEPLTYDDVVHHLTRLEKKIGIGDENNEYSLQKIIKAINKLRAGQFSVNPKAIQRAAGEFIKELRLIQYVLKGERNNDVIITLSDLKNVGLSVNDWHKHENAKGLHKIENELKLQQSQLNGQPKLIGSGVEQIANVLEEVRTALQSIDGGTKGDVINRLGALLRDAFNGSEWQNGRGKKITSLGKIKQDLHQQKESLAQQYETIDKATESVMHETQDMLRKASQKLSSDLISDTIVKNLQLLEKMIVRGQNGDDSLQGMYEKISGLQNEEIHKSSEAIFAAKQQVGKELKRLKDKLQIDVSNKLEDLVINGFGLLIKLSYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2T3</accession>
    <name>A0A061D2T3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767104.1">
        <property type="nucleotide sequence ID" value="XM_012911650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2T3"/>
    <dbReference type="GeneID" id="24563459"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200750"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="83" mass="9058" checksum="5571DE9274853094" modified="2014-09-03" version="1">MENSDILVNPLAACSNEEVSISNENSISRSVKPNVSNVPKAEGRPFAQRFTRCSTGITRLIAGGCNRENHSVKRGVVTWITNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2X5</accession>
    <name>A0A061D2X5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766628.1">
        <property type="nucleotide sequence ID" value="XM_012911174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2X5"/>
    <dbReference type="GeneID" id="24562983"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107400"/>
    <dbReference type="OMA" id="NWVFQLD"/>
    <dbReference type="OrthoDB" id="366402at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="342"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="819" mass="89154" checksum="EA720CC5EEBAF51B" modified="2014-09-03" version="1">MPETLNEPSGPSSASEQDAIASQATVCDTQESHDSDLLRQESLPLLDTGFAAVVRKRRCEHRTPRRRHYQHKSQRVSSVMLDSLNLASIRSNTSNSFCSVPSTDQGGQFCSISDRACSISTLESTISNESDGGVSGSASPLVAYASVDEGAAGVAAASSPPPVAVEGGSAVAPRSDSIQSRLSTDRDAPLAVVDEVDAPDSRDVSAPNQAVRQLTLQSLHTSSAVGADRQGAKVAVQDRDDSGYVESDCEGYCVPTGSGGADQVPATELPQQSTDEPPTLDISSVVDAAKERTVVDDGRYTYSPEAQLGVLRLFSHQGGNASRQTENPPIPPRIVINKSPFVFGSDASCDVTFDRDVHRHLCGRHCKIVFHKCDTAADALRSTGIASYRVEVVKMNPEATVFVNNVPLRSRATLRNGDVLMFGPKRFGVSFTVAFRTREACVALMDQLNSLMLTPSNESRLRRQALTPTHSSGQSSLQLASVEPSSRDLDLELHTNVAVFELYYGEPAIEGALSQDWDVTPSVFTPHADWPMSQPSPSTIRSELSYLGVSTYPESRASSRMASPGRDSSTRHGTLFGGGTGCAGSEVFESPSPYRSLRRNMESCKIVHTELNPQDFEDDSLTGKLLLSTYTTGLDPDLDAAESKPQSTKSRVDNESEMRLNAAKVAKLRSFNRTSVPIVVDSSRSLSSDDESPCLTVAKLRFLGTISATYQTTLLELMPSIDGMLQSYMDQSPTAAMRSLSDYEFLLKRCGDSISEEHYQHNWVFQLDFFDRDDPLFRRAVYASLRRNEPDRERLRASVSAAIEQLKRSRVLYIQTRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3D6</accession>
    <name>A0A061D3D6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0202650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767294.1">
        <property type="nucleotide sequence ID" value="XM_012911840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3D6"/>
    <dbReference type="STRING" id="5866.A0A061D3D6"/>
    <dbReference type="GeneID" id="24563649"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202650"/>
    <dbReference type="OMA" id="MSVCPPY"/>
    <dbReference type="OrthoDB" id="433895at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="188" mass="19061" checksum="26FF95AC1AFA2FB8" modified="2014-09-03" version="1">MASAAQPIPCDPHSSFFGLMGVVCAMVFSNVGAAYGTARSGVGISCMGVMRPDLVMRSIVPVIMAGILGIYGLIISVVIVSHSKCRAADTRTPAVGHPGSYSAFSGYAHLAAGLIVGFSGLASGYAIGIIGDAGVRANAQQTRLFVGMILTLVFAETLGLYGLIVALIVALKPVPGLCLAYAADSGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3H3</accession>
    <name>A0A061D3H3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEAT repeat family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767457.1">
        <property type="nucleotide sequence ID" value="XM_012912003.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D3H3"/>
    <dbReference type="GeneID" id="24563812"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204290"/>
    <dbReference type="OMA" id="QLDEMRY"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2449" mass="273844" checksum="E062BA76F9A80976" modified="2014-09-03" version="1">MGELPGNELRFRRALYRISAGVLCRTDLCIIEGFVDHLMRESPGDGEYTLSVRDNALEVASSFNKFMYHRVVLTLVPKLERRIRSIVNKLKILLTIHKDEIQPITLLQSKGVGLFHLALVRHAECRVEQLSVLKTLLADSQFVLSPFFASLIANLLESITCEEFETYISSDILRLLKRGQKGVAFTLFTLQKYLKPHVTLSRAVDITENLKQFLMQQDGTTIFGAEKVPYEEVKRKGPYGQVVSELIHWFSGAAFRSSNCPLAKYLRGVLDSFSGTSRLSAPNQEINAQLLLLLLPIRLEESIDATLVSNVVESYRLTIRRIAKSHPLESVQLYFIQIVGHLLALLPDSDFENLLMDILSEQMKPLEKLNQKTKDVRINDAIVSATLYGLRYVTGAYQMHGGPRTFEGASKLKGYLTTLIQFSQDKPVYKNCLFEAMFVMLHLEPDDVTYLPESSTTAAARASEQMKLSNVLEAMHINNRDPLGHLSMCENALKRQDITPQDGKISTLMGMKNIPSMVEAVTETTGSQLYATMVDLYEELCNKKDDVKHPVLACVYTRQHVERRLQDFNGTLQEHHIYNMLLTILHSSIKLKYKKSIRMLRDAWMRYNSDKHLFTVLVHCILLRCPLAEFPNGSDLSRIINSRPCKVIRVLAPVSLDENAVFGIVHHSVEEGTVPLILDHYLAFQDADVSELIRSLLLAAENTLNKLRSFEKEDFEIYLAPADKLYQDSRQYQPNIHQSDKKKFSNLTKQQLDEMRYKDQCAVRREIAHLVKKVNTTLYALSRALAHKRDYLKAFLRDFLVICKMALGVSVLRGSFSLFMDMLCQQCLIGVLPNTAGRISFILQSIYSEQDYRINYDNLNVALNDLSDSCVTSTESGILITEITTYVLSSCDTNISIKEACLRVILKFLGDRVDIGQRNIIDAVAANLRNEALYPSMIATLKEAVKYMVDHEGITSICKIGLSSTTSLVREVVAFYVRDRRPDSLGSIAKYLMIMGIDVAGLSCPVKHIIDLLPQYVECNPELLDLAPKVFLLYSVNDVMDSFQACYQEIDRMARGSLIVVLIRYFSILSENVVHSDIFDRFVLMSGDSSHVHRTLDCCKALSKTVPTQSVGLLIAHMRTWMDNKYPQALDALPSGFLAASDIVTLGVCATFMGYLQEKIKYDSQVKWNLELLLKILSFENEFSKAEAGYNSAAIIASLARICALEDEEDLLNTKIPMLLSSVSDNDFATVPCVSLLKGGGLLYLKKHNIVAKIKESLRVKGMPRELLFVKELANQFGRLFEPYVKDIFSTLLRCFPDSFDVCLDTCATVLGILTPVGFKSILPIITESLGTYSSNIKLGCLRLLSQVIKNSKLQSVIIKNVSDVVKVVSPCTTDTQKAVKDAAEHVLDSIVGLAGTESILYPTMGSILKVLSHPSDMNVLSTMQALYEYARNHPNDEGKSHATIGVVELGLLEPVLSRSLKSRNGSCRQSAIVFSSWLVYRCGGYREVELFFTTFMPNLTDHLKDTLPEIRREAARAIGCCANAFKRFGCDTSKVLMIDLINRLMKCLMESITSLERCSAAAGLAEALWAVDDVFVEGIVTKVLKILDSRDSTPQMREGCLALFRHLPLTCHDYMLTNLDTILSRVMGILCDEDERVRDMASNVIRTVIEKYHESSRDIVFNNLRLASRSKEWQTRNIALPLLQFLNTLKEDNRVTVELYIGRYDQNPTVKTTAMDIWKGMNVTRSLRTIFPLVLHSVIELLEQDDDEEDTRVQAGECITDAISRLGSDTVNDFIEAILNCDGAFRGRCIGIASLASNGKAGIEKHLPRILQFLKECLCKTCSCHEASKALATLAGYFPAVVSEVLPSLVSDLFSKDEKDAYLVGITLLIESHSECYSVILQEVLNPELDVTRLALLERMLCAKRTKVVFSQQNILSRCLSQMLLYYRAFPKETMASFSAFVSLVRAESVMRLIHILIEMLDDLAAGSNDGSKKSTLIVFVSRVLELRDCDVDSHYGNVADSLSRYIFADPGTMEASILVLDQLIKSAERRAELDNLIGAFSKYFSAFGVANGQVQQTSLTTTLPLMMSLIQKGLVKSNAKIEAAKCVTALHKLVGTEHMGPFILKTIGAIIRCLNDKCPSLLKISLLEAIHSLLHCEVTHVRVILYQLQSALFKCLSDVNSEVNMLIGPTLRLYVRLAPNKSDSVLADLLQLASDKVGKPTVKTASLHAITEVLSAPPNLTTPPFEELLRLLQDCSGTDKQLVCQAIGLSAQLEGDYGSDWLPNTSALSALSSIVLSDRGFTRLYQTTPKDFVDVLRQSLKSDMPSVNLCALNIFCRISKLTRSSPLARDFVKSYLSILPPGAKLPPSGQSQILQIYKRLLRFEQNVPNFGSQLAYISEAIYGVPLVKLEAEKVLLVLLGPSHDMDNMLSFMKQHSPSDKVTKLLSEYALRVLVKGNKNDQLSDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3L6</accession>
    <name>A0A061D3L6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767477.1">
        <property type="nucleotide sequence ID" value="XM_012912023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3L6"/>
    <dbReference type="STRING" id="5866.A0A061D3L6"/>
    <dbReference type="GeneID" id="24563832"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204490"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="672"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="763" mass="82593" checksum="C058702D151FAF4D" modified="2014-09-03" version="1">MRPGDSNRNSSLGTGSWRGSYNTPSQSTDNTVGDLGVSGTDQLLLSATFSNVPSMSESLAMSDGVASSQQDVTVSRIPQVASRLVHMRSNGNMLGFRHGLLSASCSQNNVSEQGSTTQETYCAALTLGDLDTDTSIPDICVDHVEDMALRNEAADVEAGSDAAKYETLTSRTLRALKSMKRKRSLYSASAISDNVQPGKMTGSKTKGAVNQDDAGSEGETNSQQGSQLDLHSFADSGGNADIITTSVADGNAIASLPARDMVQQGKSATAVLRKYKPNEDVDMMETGSTADNEVVDTGKVSQETRSSSINGHSARSLPFDETSTYVTQTTTGITPSQSQCTPMFDESTQEPVAEMLMPKITETWALQTPAVTKHDDIPDSAPISNAGRHTGQHNNAVVPGYLKMENNMDADSARNEIVFRFRETVAVDRNSPIHQTVHSTAASVTPVSDVGNDEIIDAAFTTNIRSSTTEGDEGFHNTADLSVTEETNSMNPNSRTDKSPTKTTATLISRDEDKGSGSPRQNSPATSDIVDARTSPQSKRAKTGKENANSPEKGPRATKKPAKPKKAKRPLLISYTGKRQGDIEQRLRKAVIYYEKGQLFFDYLDNPQEERLTHLIAPLEIQRPTLKVLYAICHGAFILTPNYLEEAEKNEKWPSEVGFEHPRWPLRASRMRPLDLMRTIRAFAPQNGNKLSLEDITSLITLCGGKMVNSAAAATHCIIPEGTEPSQIIDGELPEDTTVVTENWVVNVIERLTLLPSDLRSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3T7</accession>
    <name>A0A061D3T7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767424.1">
        <property type="nucleotide sequence ID" value="XM_012911970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3T7"/>
    <dbReference type="GeneID" id="24563779"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203960"/>
    <dbReference type="OMA" id="FSDYVWE"/>
    <dbReference type="OrthoDB" id="360876at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="26140" checksum="F6E6F9C66B8F4375" modified="2014-09-03" version="1">MAEEKPEHAANDCYEALLDLKSIFPSWSDAQDNFHFHWRDILAATTKGKEEEQDTIGFYRETLKELIESKGEGITAQNAVELITRLDTRRKERDDTFEQYNIESMLSKDTSAIRPKPPVKKQTVQRRPAAEVTADVVPEGGHVYGTRTRSRRLQAQDSENGQGGKLEYSSSGFGTHLRKGFFSDYVWDFLVPTGEENEYDDEIDQSVVAATDDDDDEEHSARKTKRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Z4</accession>
    <name>A0A061D3Z4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766958.1">
        <property type="nucleotide sequence ID" value="XM_012911504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Z4"/>
    <dbReference type="STRING" id="5866.A0A061D3Z4"/>
    <dbReference type="GeneID" id="24563313"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110690"/>
    <dbReference type="OMA" id="GHENAES"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="306" mass="33365" checksum="0D195A5D0B42F2F6" modified="2014-09-03" version="1">MTQPPLAPGCAATATCSPNAPTSDGCRTLRLAGKPPKYIGIDVDNTFHTYDAAAMAKNRRAFRKLVESGYRPVLVTGRMLKASLGVLDDLYTDGVYRGYPGVYQNGATVYNELGELIVTVSFSKSFIRDVCDILEEHRLGAHVLFQAPNEYYALAHDKDLTELLARNLNLPSPVIESTADEICGAEITHILCYRFDKVQLYMDAKPEVDYVAREGAMEITCINPPRVNKLEGLRALLGHENAESGDFAFIGDGSNDVEALQASQWSFAVGNASDSVKASAKNVLEETNDQAAFAKMAQLLYGINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D409</accession>
    <name>A0A061D409_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767474.1">
        <property type="nucleotide sequence ID" value="XM_012912020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D409"/>
    <dbReference type="GeneID" id="24563829"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204460"/>
    <dbReference type="OMA" id="ENASACT"/>
    <dbReference type="OrthoDB" id="339519at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="614" mass="66942" checksum="1869C212CB740595" modified="2014-09-03" version="1">MVAVCGMCDASPGISTPIRSARWESRLGLLVAGTIEDPISVRSTASRCGCKRMCSKGECELSVGSFDNGGVPTHGMPRSAAGNASRRTPTCIMDRKPFECLGCVDLCTISTDEEDVVPCSTALGAPTMGAVDVGRPTADSIEWFKHKDAAVKHFFTPPPCTPAKKPKASTGMQCSKRRNSTSACVALPNLTSGGIDAETGVRNDTQSSDANCVAPPAKKYTSASTIKGTSGVQRPKAYRHKVLLRLRKKQPRNNYDLALFLLLKFGGTESAAGRSVLRDGALMECSALSRFRNEDELAVFYRNERTALMGMLSRRVAVSALSQSQLNRKLAKLLPSTRWFNRPKLLQKIVGQEHWNPFSIFGSSLPYVNVSEVFENNSRAASDRKPGCENASACTGDPDVRTDVSTSNVAAASNAAANPAADSRCVGHIVHTTPGINWSGDPLLLDEVLWYLEATDKYVDKSRQVCALQRCFCVTPNPQVAFNWNDARNLAWREYRGPRASMGQMLSPSTFGESMADYEKLRKEFESQSSQRDPGRQQDSTATDKSTKILNRGTGEELESTAPDVGGCSATVESSDNSASPTFANMPRTRQAKMQQLVFYRNYFKANRLEVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D439</accession>
    <name>A0A061D439_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine aminopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0204810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767509.1">
        <property type="nucleotide sequence ID" value="XM_012912055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D439"/>
    <dbReference type="STRING" id="5866.A0A061D439"/>
    <dbReference type="MEROPS" id="M17.008"/>
    <dbReference type="GeneID" id="24563864"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204810"/>
    <dbReference type="OMA" id="LFYEYVT"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="378"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="527" mass="56145" checksum="3DAB441ACF4AF91F" modified="2014-09-03" version="1">MSTVDVINKFPSTESPAAGATVGIFHTDGVPSAAAIDGLAGPVEVFHLVFASGSPPGDRSAGFSIHKYDRFPNAFVTSEAGIRGVAGAAFSAKMGEVVEFFTTRENGSLLAEALVGCGKFADFKVSDAYNVARAVAQTSAHRKCKNVILVLGSLDIGFVEALVTGFLNHISVDRRFRKDTTTEYHLNGVYIATLAIEDVESLALRCKVLAKAMHMSRELVTAPANYANTLSVSSFLKDKLTALGLEVKLLYEEDCRALGMGAYCAVAQGSRYPPVFVHATYRGEGPTKATIALVGKGIMFDSGGLNIKSASSEIELMKFDMGGMSAVFAAAEAIGTLKPSGVVVHFISATCENMAGSKAYRPGDIITASNGKTIEVINTDAEGRLTLADALVYAEKLGVDYIIDLATLTGGCIVALGFKYGGYFANNEELNSSFVKALEKSGELAWRMPLAKEYADCLESKVADLNNCSYKVKASTISAALFLKEFVERTKWIHWDIAGTAFDRNTGRGTGYGVRTLVNLVLDLAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4C9</accession>
    <name>A0A061D4C9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein KRI1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0200640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767093.1">
        <property type="nucleotide sequence ID" value="XM_012911639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4C9"/>
    <dbReference type="STRING" id="5866.A0A061D4C9"/>
    <dbReference type="GeneID" id="24563448"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200640"/>
    <dbReference type="OMA" id="WDNYDPR"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="6">
        <location>
            <begin position="455"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="576" mass="66690" checksum="53109FD0AA5DCDFF" modified="2014-09-03" version="1">MAKAKKASKKSKKGSDTATNDTPDQEDQTVTVNEPVTSQPDYDDESSSEESSEEDEDAVLLTNKVEQKIFETLVKIKNKNPEIYAPEVKYFSDSDFEDEGNDEGEASKKAKGLTYKDMVRETLLKEGAEGFENEDDEEEEPPDVQHTKTYQEEQDDLKKAFLSVANELDTDADFFKKSSATDVLPEPRFNNRKGAARNLGADAEGLISQYWAAEQPMNEEEEFLKDYILNQRWREDKKENYDYLKRLKIDKEDEKHLDKAEEFEYKYNYRFEEEGGATIEGHPRNIEDSVRKVDERRKQKRQEKKQKKLEEKIRREEELKRLKNLKKAEIAERIKEIEAKAGVKLEEDIVDLNAPFDPVQHEKDMKKILGKGYDKKDDDDWNPAQDCADEDDELWWLCDHCNKGIPVGAKHFDCTECDNYSLCEACVPLANHEHSRMVAKVVPPSCAPPKDATKALAELEDEYYNLDYEDVIGDMKVRFKYRKVQPFKCDLQTILEKSDKELNAIMPLSKLLAYDAELPEKEMKIAKRKLEKMSKTTDANDGPDLRMTKYNVNRDRLQAFGLKEGKKAKKAKKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4E5</accession>
    <name>A0A061D4E5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765985.1">
        <property type="nucleotide sequence ID" value="XM_012910531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4E5"/>
    <dbReference type="GeneID" id="24562340"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101280"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7848" checksum="8D85DCDAC4809A64" modified="2014-09-03" version="1">MVLPRIDVKFAFLSSVSPACHHMWYGAKRQVEWAIAVMANRIDNGTAWNLHKYWREAVAPQNPKPALGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4G0</accession>
    <name>A0A061D4G0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0200940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767123.1">
        <property type="nucleotide sequence ID" value="XM_012911669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4G0"/>
    <dbReference type="STRING" id="5866.A0A061D4G0"/>
    <dbReference type="GeneID" id="24563478"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200940"/>
    <dbReference type="OMA" id="GMFQKEV"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000081">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="8">
        <location>
            <begin position="73"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="41937" checksum="DFB72BF06B1DCB1F" modified="2014-09-03" version="1">MASRRQKTQYRVEPYRICAVGPKGARQAASVAQPAAAMSQKAPAAGASDARHMSSGMVFNKKFGQHMLKNPGILDKIVLAAEIRSSDTVLEIGPGTGNLTVRLVPIARKVIAIDIDNRMVGEVKKRCVSMGYNNLEVIEGDALRTTLPKFDVCTANLPYQISSPFVFKLLSHRPLFRCAVLMFQKEFAERLLASTNEEKYGRLAINTRLFCTVTRVCKVAPGSFNPPPKVDSMIVKIVPREQPLVVDFVEWDGMIRVCFSRKRRTLRSLFKKQAVLSILEGNYKNWCTINRRAPEPVPFKDYCMQVLEDSGLSNRRSITVSIAEFLELMLKFNNAGIHFANVARPAGDKPDASSLAKAGGPQVPDFLFTDDHMELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4K0</accession>
    <name>A0A061D4K0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767163.1">
        <property type="nucleotide sequence ID" value="XM_012911709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4K0"/>
    <dbReference type="GeneID" id="24563518"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201340"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13476" checksum="DD0A721EA76B8A20" modified="2014-09-03" version="1">MQGCGVTYESDELSKPETNKIYDADGELQFGSKILLMIAAPYVLDPPGCFNNVFVDGIVKNVGDLSDSVVASRTSHFVTLKLESKRMRPGETLRQTPPLECRCVTIKGAILSTIRIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4M2</accession>
    <name>A0A061D4M2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767709.1">
        <property type="nucleotide sequence ID" value="XM_012912255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4M2"/>
    <dbReference type="GeneID" id="24564064"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206810"/>
    <dbReference type="OrthoDB" id="10393210at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="234" mass="26179" checksum="7594D04220DFBA7F" modified="2014-09-03" version="1">MVYNSLTDVPRNLKEGIDWLIALRGTDPDNNLGAMGALIYDFLLDKPVGKTEVPALEKVKLVSKEFVAQPEIRNLRFAKKLLKRYEVPMDRELDSFARSAGFYIDSDYKNVVKTRGDTHEDIATDLATVVDGCEAFLNHIKIPEQYESAYSSKATWDASCTKDPEACALVLVYNLEKPDDKVREHLADVIKAVGYGEPGCRSSMSGPDVLKALESVNLHVLISIRELAAFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4N6</accession>
    <name>A0A061D4N6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767198.1">
        <property type="nucleotide sequence ID" value="XM_012911744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4N6"/>
    <dbReference type="GeneID" id="24563553"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201690"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="438" mass="47568" checksum="4F14C592361A6C53" modified="2014-09-03" version="1">MVHTSLTVAPQDFKEGMDWLMALKGADPENNLKAMGAAVYDLLKSNALGVDVLDGLKKVQGVSQKFLDQEGLNKQLFVKEFLQRIAMPLNKKSDVFADCPHITAETIAENIGEVVNGCHKFLETSKIPTQYDSAYSSATWDASCSKNPKDCAVMLVGIAPMLYTGLRSLQVASHAAARKELGHEAKKRMDEVLNAVGYTNTKSPDKMGSSTLYQALNDVDEKVLSVLHDLAGFWAFDVCDNKKGLKVKRIMEPKDVKSVDPEAEPSVDGEGEQYVIPEAEPTFEGEGEQSVIPEAEPTFEGEGEQSVIPEAEPTFEGEGEQSVIPEAEPTFEGEGEQSLIPEAEPTFDGEGEQSVIPEAEPSVEPAGEEPVIPEAEPSVEPVKPEGDEDTKAAGKNPAKMAKVARSVKAAKKAAKKVSKKARQKKQKKHKKQQESTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4V6</accession>
    <name>A0A061D4V6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766175.1">
        <property type="nucleotide sequence ID" value="XM_012910721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4V6"/>
    <dbReference type="GeneID" id="24562530"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103110"/>
    <dbReference type="OMA" id="VEMCRPI"/>
    <dbReference type="OrthoDB" id="365352at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="891" mass="98603" checksum="E17E0CCCF51DF797" modified="2014-09-03" version="1">MSLRAGGSALRLGVRALGARRPNAGRAAGWHREFSFIRSFFETETQIDNTPAAVSLFDKETAFHDFESNLNALLSRDDARFDEYVAFLRESKYPLDGNEPSFEKYNTGNLVRLLDSMTFLSHCGHADSHTKMVDLVTREISSRPLLTEGGSGVETLINCAKCLSRNVRVPGATRLVNHINREVRTHAPMLLQHGCFVSVTSALSHIAHPSIMGMIVHTCCVRCNDLSPHDLSLMPMMLRDFKIDNSRLITPILERVGEGPMACFDSTGQLCRFFQDVASMEYMENDEGMLIEKPVNRLSAIIMSNIDHYSTSERIFLIASLPTCNHIPPDAKDMYGGLLRRVLVNIGVLLDSKGAVEMNSGIAKVLKSLTKYQLLGVIDTVCRHDPFYPDIRAEASDVINWILTAGEKGKIVGENKLKGLFKALAEEVCRRSDEAMPPSDDHTGSEPSNDSYLAAFSEDVVLMRLVDRILTADQLDSLQDTHERLLKIVANQITSKTQKRHETLYAVAKEVSKCHPSVQRALVKPVFAVLMREPDNTKEWLAASSNALKILRNCGNSKSHKDGSHDADAADAKFINQVVSQYVDALVGNDLGHLPSVAACEMLSQIYLLLKSATCKLGDNSEKLASRVSQRLLQLLRRPGDALSAKALRSLTQLPGGDKVGDFVNELMTSWANENSDQKPTGVRLSNAVEYVIASSVAMLDAAKVADNAVERIDVIAEVASERLGDLQNNIDAKFARNNYAQHGERQANTYVWEPSVGLKPLFNRPIEPLDVFLADRMKGLDKYVPAERYSGIEHYAGGIASLHQLKRYFQKIHNQISELELRITVLLKSDQEASTGNMEQLLSSLNKLSSAINGSVLAVAMAEPAWPDTYLPRKHTRRLVESALKRLVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4X5</accession>
    <name>A0A061D4X5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myosin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0207730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767804.1">
        <property type="nucleotide sequence ID" value="XM_012912350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4X5"/>
    <dbReference type="STRING" id="5866.A0A061D4X5"/>
    <dbReference type="GeneID" id="24564159"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207730"/>
    <dbReference type="OMA" id="MTYGDIG"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14876">
        <property type="entry name" value="MYSc_Myo14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036044">
        <property type="entry name" value="MYSc_Myo14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF270">
        <property type="entry name" value="MYOSIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="102"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="837" mass="93642" checksum="49FA65C16BEB3DAE" modified="2014-09-03" version="1">METVSKDEIATANALKRQGTQVQPFDASEQLLTGFQIWTDAAPSIKENPALLFVKCLVQQGSTKTTLVCTQIDPAPPAGQEKATFEVPIDRAWNTNAQLDPLTYGDIGMLPQTNIPCVLDYLRHRFMNNQIYSTADPLLVAINPFKNLGNATDAVIKSYKDAPDSLKLAPHVFLTARRALENVYDYKYSQTIIVSGESGAGKTEATKQMMRYFAYKNDGQSNSKIQTAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLDVAEEGGIRYGSIVAFLLEKSRIVTQDADERSYHIFYQLLKGASPEMKSKYKLKSIGDYKFLNPKCQDVPGIDDVADFKEVMQSFESMGLSEEQIATIFSLLSGVLLMGNVEIGSTTVEGVDDAATIVNKSEFNDACQLMFLDPNVLETEFTVKVTSAGNNEIRGPRKQSDAEVLKSSICKAMYERLFLWLIRNLNRSIEPEGGFKNFIGMLDIFGFEVFKNNSLEQLFINITNEMLQTNFVDIVFKREGALYKSEGIPIPELNYTSNAAIIEVLCAKGKSILSLLEDQCLAPGGSDEKLVSACNNQLKDNNKYVPAKVNAQLNFNVVHTIGTIQYNAQQFIFKNKDVLTAELVECVNASPNQTINNLFENVNVTRGKLAKGQLIGSQFMSQLDALMKLINSTDSHFIRCVKPNESKQPLEFNNVKILVQLHALSIIEALQLRKLGYSYRRPYELFLEQYKYIDLGITNNKSLDPKTASQRLAESVGLKTGQYALGKTMMFLTQKVAKDLTALQRQRLSVWEPITAMLDAWLTRQAARDQMFSSMEGIVRLQAHLRRRIVQSRVTPSPDQMLRMQINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D525</accession>
    <name>A0A061D525_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0208220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767854.1">
        <property type="nucleotide sequence ID" value="XM_012912400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D525"/>
    <dbReference type="STRING" id="5866.A0A061D525"/>
    <dbReference type="GeneID" id="24564209"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208220"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600058" evidence="2">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="90"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="214" mass="24712" checksum="895ED117F902D71F" modified="2014-09-03" version="1">MLVSLHICVLLTLLLRSPCVSFILKRGSQRQVVDAPRRRLELGVQFRTKIGKRPHGTSSLRDVRRSHFQELTNERCKLSKGDNKVIHDAKMLFVSNVDPEITQEALDYLIHYIHGPLTSSTRLVKDRYTQRHRGYGFIRFSTPEIATRTLLSLNGARLGNRQITLSEVISSLYQRKKMPSILQAAKRIIRKVHSRPNKTQEVDKYDVAFLPIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D548</accession>
    <name>A0A061D548_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0209440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767977.1">
        <property type="nucleotide sequence ID" value="XM_012912523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D548"/>
    <dbReference type="STRING" id="5866.A0A061D548"/>
    <dbReference type="GeneID" id="24564332"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209440"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="155" mass="17487" checksum="044DB97364B1F574" modified="2014-09-03" version="1">MLMKLQMADEITKGKGQRVQTFGRKKRAVAVALCTRGSGMIRVNGRPLDHIRPEALRTKVLEPLYVMGSKRIANIDIRIRVRGGGFTGQVYAIRQAISKAVVAYYQKYVDEASKKKIVDELVGYDRSLLIADPRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D564</accession>
    <name>A0A061D564_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0209590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767992.1">
        <property type="nucleotide sequence ID" value="XM_012912538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D564"/>
    <dbReference type="STRING" id="5866.A0A061D564"/>
    <dbReference type="GeneID" id="24564347"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209590"/>
    <dbReference type="OMA" id="YVLMYDE"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="397" mass="44703" checksum="372AB8B91302B088" modified="2014-09-03" version="1">MAGRSEKKRSHRQKTAGFVYSLIAIICEGLWIMRNVIYPSDAVKAEFSTLAWRVALITVSYVVSVYIIYDSIRVGVSFSLSNDLFCLTTAVCVLSFFVNWAFKLFYIVPLYFLYKIGAFVVGWALTPEPEVEASSKRAEKLKRKYKVISARPMEVVEDVEVKQPTASTPAAGSEESHISAKLQGTELYKKGDLDGAIDAWFQGLRALQFILNKKEEFHRDAASDEDMQKKWDFFVTSYVQLSSNMSLALLKKGDYAGCIKYCNDALQYDKGNLKAFLRLTQANVELGQFNKAIQHCNEALQIHPENAELKMLKKKVLAQAAAHDRLQRPIMKGIFQRMETDPRSLSGPKESLVSKALSKAAGIAWKVAHPVLRFLGRYVKAVLIDYVVKPFKAAQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5G2</accession>
    <name>A0A061D5G2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768142.1">
        <property type="nucleotide sequence ID" value="XM_012912688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5G2"/>
    <dbReference type="GeneID" id="24564497"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211030"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="156" mass="17157" checksum="419BD1B85B142B66" modified="2014-09-03" version="1">MITQGPKPGTTEHVFHVSSMHLQTSHILLRPSEPQCGQSTGSETPSLPTSSVFSMGLHRIRVFDVAVARGVIENERECLKRVSRCHGPPTSAPSLQSFKRSRSVANVWMYSAPVLTSPVLSWIDRLGSFAIASATERTCSSRLLETFERYPSTVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5I9</accession>
    <name>A0A061D5I9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766415.1">
        <property type="nucleotide sequence ID" value="XM_012910961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5I9"/>
    <dbReference type="GeneID" id="24562770"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105380"/>
    <dbReference type="OMA" id="DCSENWG"/>
    <dbReference type="OrthoDB" id="365605at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="514" mass="58674" checksum="045BA24C2EC97992" modified="2014-09-03" version="1">MSSLTPKAPKNTVASAEKSHTNDLTALALQHSGIRLPDRTGLLAEITAEDYDFAVANINHEYNALFTLLQRLRFEKLRKLTSQDGWNPFDLQFADVCTPIPIGDVENYSYDEQTSSCRCPNKLLPCSRHQALNDLEIWTYQLRKLLSQSKFSTRYDRLKLATKHLNIINSKGILLQAGLLDNIAIKRKQICNSVDAVLCSMRDHSRASTEWSSWGGCSEKCNRGTQERFKITYNNGVREFVVDRRTCELTKCSDLNQPNVSQCLISIVPRNKSTNAVVRTCACPTEDSVMCSSEEARITMDSWITQFREYCKKALIHNEGNNILHKDIPQLNTQYLGRFVQIRFRDGYYFDCTERWGMIDNDDTTSYCKIGSPILCREHITKSNARAFTFKLSKTYNKKFMGFVAPLHATDVDFIDIHFRDSLFDVTYNIYGKQIHSIWLYGTILSVDYDKELFDFNDGSGRILQIKFGHTFVNSFAENEDVIKKGSLVSIICGLSHVIVEQDALLCLRVLAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Q7</accession>
    <name>A0A061D5Q7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768242.1">
        <property type="nucleotide sequence ID" value="XM_012912788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Q7"/>
    <dbReference type="GeneID" id="24564597"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211980"/>
    <dbReference type="OMA" id="HAAIRIN"/>
    <dbReference type="OrthoDB" id="366056at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="911" mass="101628" checksum="46908B75BCC68344" modified="2014-09-03" version="1">MIPPSLPLTVEEADENVVYMCFEDHVAADNATFGAIRNLSCGRRDDVQFCDEVSLTTSDAVDIDESDFLVESSSEASTGDPAERKPHVSTPVRNHRSGTDTQHSSKSGRTPERATAPPVGRPDGESGADATGTSPSKSQRRETVTPTRQTTTPRKAASTGRTNSSPHAPRFHTGYHVTSQLSSATSVASDDTPLQPAPITPSRSAAPGDSAATLLEKVMYDAGAYTVDSIDSEFQQSYTPAPAAVMGFGSMVTPARNELNMFTALSQLGDVEGLVAFEKTMYQTCVLRSRAFDVAWSKFMQRINDIIRISVQEGMGVILELLERNAVSDTMLPIILVDLGVVSSDQRIVLDKLFTSLSSSGDKKHVFVKVNIMGNVQASLESIYTSLKGLMPNNRKNSVEAQPLDISVRKSIMEQIVDLFKTYFRSRNLVLIIEKITNNLNELLFIFEKFKSCEGVAISCILCSNCWETNLEHHISPRVYSGLSIVNCDVVSVNKLSDDLLNVLLFDSEIQCFIPHMHMLQQSWNMLYNEEMSVSALIKRIYSMYDSFFRNSQFSFVCMPDIVDMRSAVHVSNNEPYFEVYRNEKMARDLFIKLGLLFCGCNLSESHVAYLQVILDKQASMEAFCLQVMPYESMKLIERRLSLQLGIYLLNTLMGLLPDCDRARSRLGMLVKILCSEHAAIRINDLIKRISRVIRAKQDQSLADLIATMKDLGIHFLTFYPAAESISRFLGTPPKYDLVEEYLDTVRADSTSTTVATFVEHALGMLMLPTIQSCSKLAYQMVVAKFTPFKTEWHILRDILEQNECTGFAEDLKHLIRSSRTLSTREVNVWDLFCLFHAKFAADPISKTFVRFSMALETAIHILGYYAVSTSKVVQLISPGIESCSSSSVRLAHVIKGRLSRFKVRRIHMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5W9</accession>
    <name>A0A061D5W9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768144.1">
        <property type="nucleotide sequence ID" value="XM_012912690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5W9"/>
    <dbReference type="GeneID" id="24564499"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211050"/>
    <dbReference type="OrthoDB" id="10515740at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="218" mass="25073" checksum="8E392DAC91CD1AF3" modified="2014-09-03" version="1">MLSDRVWWRGPNTLAPEEAQTMRTHHTAATGKPRAEMNPLALLEQQCLQTGKDKEYRPAEGDNAGDDSPVEAQAPDSNCAEKPQVEVLAHFTYPVREQHTPSDDERRGRWEQAPVHTPLGKRERRARSRSRSRSRSREQCRHRPRERREKREERTHRTEDSSANDNVGKAAAGSDPLPQTASMHQMSPIDRMLLRREQLLMRQSAKFLNEVKRQQDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D664</accession>
    <name>A0A061D664_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767693.1">
        <property type="nucleotide sequence ID" value="XM_012912239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D664"/>
    <dbReference type="GeneID" id="24564048"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206650"/>
    <dbReference type="OrthoDB" id="114080at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="203" mass="22976" checksum="6BD219F842AF3F5E" modified="2014-09-03" version="1">MGKKSSRITAKAGGKCVKKAAEKGVSAPPPVAQRNRGQLLLRWLSFELQLLQRLVYRVGFADVHVACGLPSCLSLIVTQNKNQHRSSAFMTAVCTSIRSLKRFIKLLDLRKPPAVLSKLHLDDEFNRVFYQTLRSVLDASVEISRVHAHHFHVPLIAVLLSVYGYVRYRLQRETVHGVLSPCLFCHYLRCDMYVCECYVGVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D670</accession>
    <name>A0A061D670_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter, ATP-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0300960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768377.1">
        <property type="nucleotide sequence ID" value="XM_012912923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D670"/>
    <dbReference type="STRING" id="5866.A0A061D670"/>
    <dbReference type="GeneID" id="24564732"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300960"/>
    <dbReference type="OMA" id="CRLYEPQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000299">
        <property type="entry name" value="ABC transporter ATP-binding protein/permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="12"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="318"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="557" mass="60439" checksum="F886E3033B12E6DA" modified="2014-09-03" version="1">MLKEWPFVVPTFVALLASSAFITVFPSVVGTYINSFSTESAPSMVQGSFFVMGAAIASFMKCLLSGLASLRMARRMREDLYASMLGRDVSFFDKNSSGKLSSVISTDTAVAAGIIDHLCQMVRASASFVVGTYFSLKLAPVSLMAQTMLPIVALMFIILPLSRCVQRQTAVQMRRLAALISHTEERFSHMKTVKAFNAEPIEQTVFAEKMRHLFTASVKAALYNASMNFVAVGAVGSLIILTVNKSASLILDGTMQIGDVTSLLMYTALVGGSLQSCTSSFAEIRKCIGAAVTLASHMDGNNVKTTSKHSLTSVPPEIEFKNVYFSYPLRPDCAILRNLSFVLPSGKTLVIFGESGCGKSSIIQVLLGLYAPNAGSVCIDGVPLSDINIKELRSLCGWVEQQGALFNETIRNNVLYGNVHETVDLQDSYKRSGLMEVLNSMPDGDKTMVGQMGKGLSGGQRQRVSIARTLARDPKLVLLDEVTSALDVESEQQLNRNLAEFLREKTAIVITHRPTLLSLADYVMVMHEGKVSQFGTKSDVVAAPCDQLSRLLHPCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D683</accession>
    <name>A0A061D683_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768254.1">
        <property type="nucleotide sequence ID" value="XM_012912800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D683"/>
    <dbReference type="STRING" id="5866.A0A061D683"/>
    <dbReference type="GeneID" id="24564609"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212100"/>
    <dbReference type="OMA" id="YDIDEEM"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="566" mass="61835" checksum="36E1659FB4FBB9F0" modified="2014-09-03" version="1">MLKGLPDGVVNFEAPSLFEELGAVSGQLSTGDFAYTQRSYWTSNRKALPHQEVFKQFFLHCASCDVSKVKRKDRRSDEVDDIDASDEEEELRDVDGMSDESGFGDERMSDDVSDSEEFDEVSDSDGEFDDTSDPEEFDEISESEDEFGKVAGSDEEMDAVSGSDEEMDAVSGSDEEMDDVSGSDEEMDEVAGSDEDMDEVSGSDEEMDEVAGSGEDLGEAYDIDEEMDELSDFDDMDDSSDSDEEMGEMSDSEGGNVGSASSDESEVDETPVSKLKTPKAKVQPSKVVSATKRDAKAATKKPSKSKTKEKKASKKSAAKSEAHKSLKPKAPEVKGAAAKPVKADAAKSKEPKAVEPVAKKQKKKQAKVRFADDVVDKTSKQSVGKRATVTAATPSSKKQGKQVAESVPKDTPHPKKLKEKGKQVAESVPKDTPHPKKLKEKGKQVAESVPKDTPHPKKLKEKGKQVAESVPKDTPHRKKLKEKGKKKGTASTVPSKAKSPRGRDSSTEPMPIVVESKRQKRKREAREREEAHPDYERRKKVSLLLQKATKGSFADISDIPGMDEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6C1</accession>
    <name>A0A061D6C1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768289.1">
        <property type="nucleotide sequence ID" value="XM_012912835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564644"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300080"/>
    <dbReference type="OrthoDB" id="366966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1815"/>
            <end position="1838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1877" mass="211570" checksum="C01BC69EB0E1A1E9" modified="2014-09-03" version="1">MAPKKLTDCPENLREAIDWLIQVRHGDGNGLEQLAKALKKLIEEAIEKAYTTNVSALLKALDSAKSYKCCKDKVAEVEKLRDSKNLSSKTFENLKSKCEGIKNCTKNHLDDSQQKAYDGITSKFEQLKKLEESLNIFTSKDTTDGCKKLLENLCDGLEKFLGFNSTSKGYDGTGIVYSDLDRLCDGVMGFLSGVLKDVSEKQPYSVGKNDLKHFVETELKTKLSTGREGFKVIEQVARKVREYNERVRQSNEKVKEPINAMLSEMNDYKNNALRSKLPDENLDDYKATDNAVSKADTLVHECVEKSIALENALTVAHENVLDLNHELKVKIIDAKNSVTHERERLTKLSRKQWKDMVDMKNEICNMLEYLKAEFNVRIDDDITSLVEKLKASVRIIKEKLMDINDKLIHSVKQMEEWMDEVITSINEARNQHVSKILGEASGGENTRKGHIKNITKKVSQEFQEAEAYVKALVGVALAQVKSLNDGLRFDLEEVRNQMNENIGGYVKEYVEKVRGELNKITNPYTGIDAIEKSLKQWAGDYDDKNFENRIVDWLADILQNSEVVKEKLSEYFLTVKTKVRNDFFNSDYITQENTINDGQIRVIANLIKDSLGSDFGVLGQLVTEQIRSAEKSNDKIRGYIEAVKTGIEFFVQDIERNIKQGKDEKPMSTGIYALADKIAKAIENKVRNTAGTSNSAYVINMINAVTPILHQLLAIANEKATYLKWLTGKGSKQGNIGYVDDALKVALNLNAKLTIALLRNGDSGYEDTKAFVRRSPVQNQLEANVEKTIVEALNGKIGTSNASKVNLSNLFNQFRQRITAAVDDRNKLNGTEEEGTLPKAIGAIELYGLDKLGKRLNGNPNVDGESIGFLEQIRRHLNAFAKEFDTCGRYIDAHLHNLKTDRIGNVLNAIRNNLDALQRDNLYTVIQDVNRFLTTDANELKTQTILQLKSYVTNQLNSTSISLTHLSQKQYVTSIKYMLNAFSTKVRNELHQLPEAIESDLDIGFKGFMNAIEGEATKNIQKLQYAVDLRSLCHGFEAFFLPLKKFIDSEIKRVHENNNLQKNPNPLEPESTYTTKINRIYSALSTLIGHIITTNRYDHKIPGMLSNLMDAVNTLKPQSFEQGNTPILDGVTDGLGKFVDEMRKAYMSRYDGAKAITWDGTFTNKEPEESKNAKKICLTVFYTLFHNLHPLFYKASTDWRTQKIQGGENNMHLRKFIEDLGYDVANLITRDDIGWNVAVRLGKHFQKHGEFNEDPGKHKSFDKYIGYYKNKGVISKLFSHLNDYYYVCHLAPAKSPKQPCNIFQMLAWLCGLTYNSVYGDLSLNGFGGLFEESKQEEEADPDGISLKVDDDETLSAYPEDITGTKLRDSLTAVCHSAYDVLTAVLGHGHNDGVYASDYFNNNLNLSYPTSGSACLDMLVDILHRVHHQMGFLLKQCLNGPDSSGWKDCWYGRGVGGSSWRCNTWQCPKQIDGQACTQIANQRADQTCNQHASCGLKSPLQSFLEDGLAGFLPHKITKPGCKLDCAVSNHRGLPCKTPMGFADISVKASHTKKGSHLIELLTGFCGKRDSPLVNLCAQLTCLMQRVPQTLDDMFSFYSNLLKDWNKNDTHRRLAFDNAVTKAYLNQLYDALQVDSIFSGGHSINHAKGDLFSLTCGTDSLSKSHCGRYLQPFSMNTWSVFSEKNADRYLTWITYLTETFYVLLKNIYDECCKNCATPGSRCYEKTCYKNCVVSQSAEHHDKCKSIAACNFTRPTLCKYGFVLKSSSNLSGTNGNKTKRTCQDFCKTLKDVLQEDRVLFILAYKTIPEFLFTIRAPFIWLNVALWLLSLLYLICVMIGRLDVLHIKSHLRSPSSHRIAAQSLLAAARVGKLSKIWYLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6E3</accession>
    <name>A0A061D6E3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RNA-metabolising metallo-beta-lactamase and metallo-beta-lactamase superfamily domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0207420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767773.1">
        <property type="nucleotide sequence ID" value="XM_012912319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6E3"/>
    <dbReference type="STRING" id="5866.A0A061D6E3"/>
    <dbReference type="GeneID" id="24564128"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207420"/>
    <dbReference type="OMA" id="DCGAHCG"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="12">
        <location>
            <begin position="352"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="823" mass="90736" checksum="51780AD71E2C4F44" modified="2014-09-03" version="1">MSSVDITILGAGQDVGRSCIVVTFPSRRVLFDCGAHCGFVDHRRYPDLQLLGDPNEYNALYNEQMNAEFDSSASDGDSNSDTATGDGGATTSNTADSRGQLGAKTSASNVKDKTVRIATCMKNALQKTLINVTEHIDICIISHFHLDHVGALPFLTEHLGYNGPVYMTYPTRGLAPILLRDSAQVVASKFRNTVDTEGVSHGLNVLLNRTKKRKSLTVGQLGKVDPWGYTVDCVAQSLGRAQVMQLRATQEIGNVSITPYYAGHVLGAAMFHVECDGISVVYTGDFNTSPDKHLGPAYIPQLKPDVLICESTYASVVRQPRRATEMELCTVVHDCLIGGGKVLIPVFAVGRAQELAIILDNYWTKLQLTFPIYFGGGLSERATSYYKLHSAWTDSQNIPNLSENPFAMKHMLPFDNSFLNDDRPMVLFATPGMVHSGLSLKVCKLWGPNPKNLIVIPGYAAQGTVGNKLISGEKLIHSTIGTIEIKCKVRYLSFSAHADSVGIMRLIKQVQPKHLVLVHGEYDGMKKFAKHIALDFGIPVFHPANGQTITIKQAKGGAKMPIFYYPQLLLEASGIVLTAKDEIGHSKHPANAIGSKPTSELNDSRGAKDYDYFAASDSDSSIDFCIKKLEEPADHVSAIMFRLEDGIKSLSLHSNNADAAGEDKPTDAVKEEASGETPGSPKTSPKLEQLKETKGREQLLMVSRNHMAKMFRDGVTHLSMMPELRCHRVKYRQSFKCRERDFVEATEYVARVLNGDKGYFVEELPIYAKTMESGVLRVGGLEARHNPEDDMATMEWYYHEMQPNSIVYTMVHFLEKVAKEQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6H5</accession>
    <name>A0A061D6H5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histone deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0301850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="4"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768467.1">
        <property type="nucleotide sequence ID" value="XM_012913013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6H5"/>
    <dbReference type="STRING" id="5866.A0A061D6H5"/>
    <dbReference type="GeneID" id="24564822"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301850"/>
    <dbReference type="OMA" id="DKMMGFC"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09992">
        <property type="entry name" value="HDAC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="268"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR96281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="902" mass="100281" checksum="238E0A21500E95B5" modified="2014-09-03" version="1">MDPPELVAICCDEKTMCSRRHCDTSGRGHPEDPTRLKAIIDLLRHGRINLESYGERFLADFTRTYACRPATLEMLLYCHTESHVRRLMGFCHDVEELNAGCAADDVCCHSDSDYCTSYPVDEDTYVTKESERVARLAVGGMTHLADVIMGKADMYSDMQPEDAFDTAADQQRDRTRVKRESEPDIDSNDLSSQLKAAEGAENLLNSGDTAKAASQQHDLRKDRNVAVEHGTTVGAGMERSDSSGKSPAEELNNSEFIGDVAVQLSALSVSDAQANVPRRSGVRKGFSLTRPPGHHATRDKMMGFCLYNNVAITAVHLLRNHGLKRIAIVDIDVHHGNGTQEIFYDNANVCVISIHRYGTHNNAFYPYSGNYDEIGGKGALGSNVNIPLTAGYGTHDMVYAFQEVVLPKLERFKPEFILVSCGFDAAIHDFLGGCGVTPECYGWMALELSKVAERHSKGRLLLAFEGGYNPAINASCSDAIFRTLIEYETDRRVKRGCGYNRSKVRRGTRFVCSKLRGLLFSGGDSVVDTSSSLSRSRTHSPLAPSVTPSARTAQVARPPDLKWTEYHGPMTKNSFVIAGGHPNQFLIPVNVPSGDLCKICSPNEVAFYRWLYRINGIDLEVISRPYPYLRLPFANGVVDVSITGFRPVTDSAASPTTKRLNRANVVHSPDPVVTEGLNLLKPLIRFVVQCTGVYTESVFAAWPLQYSHRAAVRLRNAIHGMRTPCVMDIKMGTRLYGDNVTDSKRIAEKQSKAEKRSCSVHGFHISGMFHWCREAKKLFYLQGNVANTLETRAKLLYAFRLYFARFQDTLLSVRICEKFLQRLEELRMLFEKQNQLAFYGSSLLFVYDSGTVSTGAATELANVHMIDLSHVSYNTGCIDEGYLLGLRTLIELLRETRKSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6J4</accession>
    <name>A0A061D6J4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768364.1">
        <property type="nucleotide sequence ID" value="XM_012912910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6J4"/>
    <dbReference type="GeneID" id="24564719"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300830"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="22040" checksum="6D10740AD1A1A20C" modified="2014-09-03" version="1">MMGTEDKNLFTWLESFVPRTDIMYQKKRDDGLTDNCMIFICGPRHLVLSDVLQHNIYHYRDYQEDTLPLNTTMPLTEEITKMGHQLGIFYQNRTCHVKAAKEAAFCAPPYVLHPSNCFNQVYVDGEVKDVIEFSQSLVASRFNHFVILKFNSELIGPYETLRQTPQLECRCVTIKGVVLSTIQIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D798</accession>
    <name>A0A061D798_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768028.1">
        <property type="nucleotide sequence ID" value="XM_012912574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D798"/>
    <dbReference type="GeneID" id="24564383"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209950"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="64" mass="7353" checksum="222EE4A59EE149B1" modified="2014-09-03" version="1">MGRHVALSRAPIDKREEDEAHREKYFASFLKKVRESPEDGEEINKPNKAKSNASVRGYRLGKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7C4</accession>
    <name>A0A061D7C4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0305140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768797.1">
        <property type="nucleotide sequence ID" value="XM_012913343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7C4"/>
    <dbReference type="STRING" id="5866.A0A061D7C4"/>
    <dbReference type="GeneID" id="24565152"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305140"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="264" mass="29516" checksum="D13BBBC89CEB45C7" modified="2014-09-03" version="1">MVRVKKSHQIWNTGTIDVASLPVIDPKLKPPEDFDRRTIKRPDIVLCLAPWATSKPAHDSTDIPETELFSAKAPRTVRDMLQWLAGFKNEKHHDTLKQCIKRAFGGLHKDTSQLALFINHAKIRPGDVFDILQLTAMFAGSVLTAIASNCKENVPSRFVKPKSSDQSDDPDCCALFCQLRDYAYACHHYAVKQPSPLQAFLTDDWDSTFDTHPFDPCNLCHKSRVRMGFRTEDLPKTSQQGSVISTILTPSSGGEGHDALLDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7E0</accession>
    <name>A0A061D7E0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone acetyltransferase subunit NuA4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0303670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768649.1">
        <property type="nucleotide sequence ID" value="XM_012913195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7E0"/>
    <dbReference type="GeneID" id="24565004"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303670"/>
    <dbReference type="OrthoDB" id="366092at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36082" checksum="3A233849ECB2B4EB" modified="2014-09-03" version="1">MSASPSALLLPAECAGFGDSPSLPRFIVGEGGQQKFVTYKRQDGMSKTAVNADSSNSATAATSTPVNASKPVTPTASAQRRTGKDVPSGTRRRARRSKATDSATRSPFLANGHVSDISSISSLGIDVSGSGVLSRTSSIASSKEGSTLYKSTLDRFTQPVRSNERAADHRKHAYIDSTLLDEALDAEDIAKARAELQDVDSLSLSQSHSFSTMGSAEDDDERRRRRRKCSRLQETIMRVLAKTKSDIEHLEEKIASLEEQYFYQPAETTGLVKGWDNALMGGPYCNPNSNKARKGTPPKTKQPLSHSLSLVNDHIFSLTSSTCSLSKTLTHKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J0</accession>
    <name>A0A061D7J0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0211000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768138.1">
        <property type="nucleotide sequence ID" value="XM_012912684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7J0"/>
    <dbReference type="STRING" id="5866.A0A061D7J0"/>
    <dbReference type="GeneID" id="24564493"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211000"/>
    <dbReference type="OMA" id="TGYSIYC"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056321">
        <property type="entry name" value="Microp_dom_apicomplexa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF301">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23510">
        <property type="entry name" value="Microp_apicomplexa_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Microprotein" evidence="12">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="119"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR95952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="292" mass="33677" checksum="CFF9D8810ED98A73" modified="2014-09-03" version="1">MILPEMDDARAYRAIPSDPDAVEEDDTSRCRWGPNPRHLVATLSLLVVEWLLICWVVHLGEAPRYYLIFASMYAFAMGVVILVNRSNPGFVPKDTDLELYRREALPATTVELNHTRFVQRWCVSCRMYKRPRVKHCYECRRCVSRFDHHCPWMSNCIGANNYKLFLLFWQHYLGLQIYSLYFIGQCISAKSADTDVSLLGAAVRSVASEHPLLVCILVVTCIRLLLAGCVFAAHGYLVCRNMTHYEYRSQPYKGNNPFDLGRCGLHRENVAIGLYQNLRAFVLLPWIDFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7N0</accession>
    <name>A0A061D7N0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Endoplasmic reticulum oxidoreductin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0211428</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768183.1">
        <property type="nucleotide sequence ID" value="XM_012912729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7N0"/>
    <dbReference type="STRING" id="5866.A0A061D7N0"/>
    <dbReference type="GeneID" id="24564538"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211428"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211428"/>
    <dbReference type="OMA" id="CYKDRLH"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600666" description="Endoplasmic reticulum oxidoreductin" evidence="17">
        <location>
            <begin position="22"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR95997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57318" checksum="027280FE1D42FD68" modified="2014-09-03" version="1">MMRMLALGAVAWLFYPIFVCSVGPMGGVKNDAITRIVVPAHAQQVLPMNGKFSPLHSLTKYVSIDGDHRFTFEQMLSDAELVHAKLAPIMRSLYFRIFRVNLDSPCPLRERNDICSHGNDGVADFENDANGPLESGECIPKCYVGRCQPHEVSSSSTLQTLEHFVLRYSEDDKFAELDLKDLYANNHWYTDILGIHSQREDKPVYVDLLHNPPSHTGYRGGDDWNQIYDLQCDCGDEVPCDQTEHLFRLISGMQSSVAAWAAWNYKCVNPVAAFQLKSELPRYVSNPDLYAKMLGNYPDRMENMYYAFQALLKTVCRLSPFLTGFANNLGQHPEHGYLKQHLMEFLSAEYDLCSDVEPAYSPHPREVCEPTHTCVSSPQLKHPVLLQKFKGIADIVDCVGCEKCRLHGKLKLAALQIAVRAFGQAEQLVLERNEIVALLHALDYFAQSIIIVHKFDEQQKRQMVLYPLRAVAALLLVIVVAYRKELRRAFCQCSAEPENREAEATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Q0</accession>
    <name>A0A061D7Q0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768902.1">
        <property type="nucleotide sequence ID" value="XM_012913448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Q0"/>
    <dbReference type="GeneID" id="24565257"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306200"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="61" mass="6640" checksum="040F49F0EEB0E003" modified="2014-09-03" version="1">MATLFKENTPNPVSILVISAANGVVGFHGISPFGRLPLRLSHLVLPNYLCATPKRLTRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7S5</accession>
    <name>A0A061D7S5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768922.1">
        <property type="nucleotide sequence ID" value="XM_012913468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7S5"/>
    <dbReference type="STRING" id="5866.A0A061D7S5"/>
    <dbReference type="GeneID" id="24565277"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306400"/>
    <dbReference type="OMA" id="LCYGLWG"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595876" evidence="2">
        <location>
            <begin position="23"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="602" mass="67552" checksum="07F28FAF6A1A6F72" modified="2014-09-03" version="1">MYFSLLAAAGLLVVARCIRCAADVVEEKLTVQPLHDGSFLLALDVSVTTGRFVPFPELMAYPGVLMDVMAPDFPKLFVKSRASHVEFTHHLGDWHSTWGCSQFPVFNTGETLWATWPHTYSEVEVYDFFETLAMGLWGITGAQLHLLTSRQSFIFDMNRVVTLEEPVSSKPKAKSLLSSFADDVFCVDNLYKWRTALPSLGQDGLLSLVNDERVWSRSPYKGVRMRMFKQKGQLTVAVQFQLVIRHKPLTKALWSIYKGATAPRKLLDATASAVEILLPEPLRGGFGGADRLVFDYLDDAQRASIDEAFAKLAAATQRGFKHSCLPPLSFKVYELESTTLNVQRRVQSSLSIIIENNQSDAKYIKFMQPLPYWLVPQISSLTFEVSRQPGESGDPGAVHFSCNGGACFKRTVSRKHLLEGYALMKSQTESLREMQPRWIMEVGMTRNRDGQISVDLSGEYGADLVGNLDEALFVFDRSEYWTEFGFSILLPAESRITCRVDLQKNQMRFSEIDYSMHRGQLIHSAVILETQEPVVEDISQPGVQLHYPGAFFSHVVLPDNTMSFNVMGGVGVIIGLLFSLVFHLGTSRPPRETRVTQSKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Y7</accession>
    <name>A0A061D7Y7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768303.1">
        <property type="nucleotide sequence ID" value="XM_012912849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Y7"/>
    <dbReference type="GeneID" id="24564658"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300220"/>
    <dbReference type="OMA" id="SEHANRG"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="263" mass="28866" checksum="A7FFA6FA429D7D4C" modified="2014-09-03" version="1">MVWEAVEVKLPTEVTDMMALDARQRAAYTPNVQVKNFSNNERTRVGEQNSLIPEGQLHDLMKNNVSWLMDLFSQSPVHLDTTYGAPRVKIHSPTCYMFGLKSKYMPSGKLQELDVRSRKAAPDAALAATVTAIFESEVKYIDPSSINKPVKEAANGRKVGRTSRDVDGCAGIEVSDEDACGDNECSSVVDSEHANRGTKDTTKSQIGVAVKDVPPASADGRSADGHEALLNHMRFVCHFLVYMAQITLCRIGVCSEVRGHYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D844</accession>
    <name>A0A061D844_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MAJOR FACILITATOR SUPERFAMILY MEMBER protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767280.1">
        <property type="nucleotide sequence ID" value="XM_012911826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D844"/>
    <dbReference type="GeneID" id="24563635"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202510"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="452" mass="48982" checksum="A93381D4850360F0" modified="2014-09-03" version="1">MSEIGNQGTTSAKSPSKKYEGFATALYNFVSLVEGYDQQMLPMCMRAFEITLGVSQSQLSTMATMSTMSQLGCCLIWGILVDNNDPQYLLAAGLLVVGMASILLSTASHYKVILFLRFLHGFAFACIYPSQQRIVSDSQDESKFSMVFGYYGWRTSYVMLGYMWILVGIAIALWMKWSPNTNSDTAANGQQPIATSANKGSFTAEIKQSFSDVFTQPTPGILILAVFISEAPLCAFSYVVLYLQYLGVSDVMAGAAVAVTLIGAAVACAAGGMVMKTEGLKTNDYLHLSCGVVVMVIRLVVCLCFFLGPAPPGRLLWYHYIEFALIGASLMTVGAVDRPLINNSIQKKIQGTASAIIRCISGIASSVIFYQLAAYLSEKVFGYVPSREAFDVMEASIKDRNKEALRKSMMYIIVAGSVLNTLCYIALFPIYPGHKQNLNKENGVAAAAKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8F6</accession>
    <name>A0A061D8F6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p36 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767385.1">
        <property type="nucleotide sequence ID" value="XM_012911931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8F6"/>
    <dbReference type="GeneID" id="24563740"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203560"/>
    <dbReference type="OMA" id="VTNHFKI"/>
    <dbReference type="OrthoDB" id="10054414at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="213" mass="24124" checksum="27E3265FB58BD73C" modified="2014-09-03" version="1">MSDAMDAFHAVMFACIANKEFQGISAEESADKFVTLLEQNGIKCIASDFDATMISNHSGGYCDPNVDVDVLSSVTEHFKAMGRRLKRSHIKLVIVTFSDDTHVKDHPVYISGARMVNKALEYSDCDARIEKVYDFYPRYWEDPSRYKLLGLNAPMPRCKEYHLNRICEDFGFKMNEIILIDDDIQNCKNAKEIGASALHVTHEGFNLAEVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8M9</accession>
    <name>A0A061D8M9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0307870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769069.1">
        <property type="nucleotide sequence ID" value="XM_012913615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8M9"/>
    <dbReference type="GeneID" id="24565424"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307870"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="81" mass="9189" checksum="EAD58C497F9AA9E1" modified="2014-09-03" version="1">MALIDHNIFPGPHIDRVMTLLLCNTNKVGVRLSRRQLSADLVSWMQLYGKGEGKEAADLQLVVKWQNHDCDLENRVSGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Z2</accession>
    <name>A0A061D8Z2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769204.1">
        <property type="nucleotide sequence ID" value="XM_012913750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Z2"/>
    <dbReference type="GeneID" id="24565559"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309210"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="95" mass="11101" checksum="01A65F19C025AE01" modified="2014-09-03" version="1">MGNNKYHEEPIGCEPSKNCMCIVDPVVLAVIFFIYYLVTHPLPDLQKARDYFSDILGTRKFRFIPRSELDVPKITHITEEMDINPYSFFPSKDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D927</accession>
    <name>A0A061D927_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0105390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766416.1">
        <property type="nucleotide sequence ID" value="XM_012910962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D927"/>
    <dbReference type="STRING" id="5866.A0A061D927"/>
    <dbReference type="GeneID" id="24562771"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105390"/>
    <dbReference type="OMA" id="HNEGYIR"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="304" mass="33335" checksum="0DFBF81F56A0C6C7" modified="2014-09-03" version="1">MDWDASGEFMVTSSLDRTVYLYSVNKAGLTNVLQSKKHGVSAVRFTHEGPRQIVCSSSRDTPTASVKLWDTVENRYIKSFSLASPVRRGRAISPHPSRDLMLISTWDTCLLYTYDNSSPLVSASYNGASMIGAFDSLGLIFAICDSTHSRKSLSLYDMSKYQAPFATFDLGKILLKSEEVVSVDFNPNGRSLVLGTNYTRLLCVNAVTGSAAFACCYSDEPAIIKEQKVFCYPSISSDGKYLLCGCTNGSISIWNFKGQSVCSLVGHEGPPYFACFNPRKAMISSACVKVAWWQPALVNSDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D952</accession>
    <name>A0A061D952_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766436.1">
        <property type="nucleotide sequence ID" value="XM_012910982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D952"/>
    <dbReference type="GeneID" id="24562791"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105590"/>
    <dbReference type="OMA" id="SYVEPWH"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54207" checksum="862A4F9528AEDB17" modified="2014-09-03" version="1">MLCEQPTERHAFVSYLKRWDEYLRVSRYSVELSARKLNPVELQLQAICDILHHQRKRYHDRIMHQRLFPMQPPLVAALGVELASEMEGLISRHENYGVERKGWFHTAVWSRNRTMRQAENFQTFEREAFQTLSRHWERQGYVRPEETVSDSCDAAINNCSIRNRSETVPYLISWEEQDASIGDSSQINAREGNQQGLKRNHTLSLAALDRISSHLKTYGVFATAIFLRVGSGVAVLRNAVDKQDVWAIRRMLHLNGSMARESAYKIVEYDPNVLVLKHTRGRIHCLLQGTSFDRQLVALQQFWMPIIYYTLGRHFYVSNINLISSDPMSYVEPWHRKNRHFGICILLSLDDINEKTGRMQFLPGTHRSGSEINPYSTGKAAVDLNIGDVLIFDSRLLHRNTSEFNDSARCQSCLLYTYDYTSTPPPGQGVNICVTDVKITVMQGLLSLCWITCEASSSMCCPTHRHNFGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C9</accession>
    <name>A0A061D9C9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0106040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766481.1">
        <property type="nucleotide sequence ID" value="XM_012911027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9C9"/>
    <dbReference type="STRING" id="5866.A0A061D9C9"/>
    <dbReference type="GeneID" id="24562836"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106040"/>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="20914" checksum="693C414623B11EA5" modified="2014-09-03" version="1">MGTPSSAYDGLVTYVDNRKVPAAKYVADIEKLVGDRDPAVVTENGKELLAKYRFMEKSMVTKLTALHNKVPELKDALTIIAQIEKRGADDGGDMYTYFKVSDTLYSEARITSTKTIFLWLGANTMVEYPVDEAIALLKDQLNVALESIEDIKKDLSWIRNQITSTEVTVARLHNYGVMKKSAATAKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9M8</accession>
    <name>A0A061D9M8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769572.1">
        <property type="nucleotide sequence ID" value="XM_012914118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9M8"/>
    <dbReference type="GeneID" id="24565927"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312890"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="124" mass="13629" checksum="27496D49F869E270" modified="2014-09-03" version="1">MKYSGKQQCNAARDRKDSRELNGGNNDGGNMEVMTLPYTCCYFADVGNNSAAKLSLDAAVVLVGTTLNCTGLRLKDPRSARSVGTKAVKIDRHCNVETGLLNKSRITLRTTRRFEQTLRPICDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9S6</accession>
    <name>A0A061D9S6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="3">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0208230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767855.1">
        <property type="nucleotide sequence ID" value="XM_012912401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9S6"/>
    <dbReference type="STRING" id="5866.A0A061D9S6"/>
    <dbReference type="GeneID" id="24564210"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208230"/>
    <dbReference type="OMA" id="WGLHLKS"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF60">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="42484" checksum="8F81A97A10445110" modified="2014-09-03" version="1">MCAVHGFRQTQLHNAPNALLHAQIDKTMDSCNVSDPVTRARKTIVVILGPTATGKTDASIEVARVLKENNIKAEVVNADSMQVYDGFDVGTAKPTQQQMERVKHHLFGYVPPTTDYNAAKYVATASQLIEQMHDNGILPILVGGTNLYIEALLWPSVIDLEGKEAECNNDPYQGIPVHAATKHPLEYDNAELYDQLTALDPQRAAVLHQNDRKRVIRSLEVINLYGIKHSELIKRRLEVKQKSGPKYDALIFAMICDPTEHKKRIKERARKMLQDGIIDECKNLMSIMGALKYFRQLLNHAAYKEIIPILKQTEDNGAELDDATIQRCADALETATWQYARRQMTWIKNRFKADSGLNTILLDTTGMWNSSQTTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X1</accession>
    <name>A0A061D9X1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769697.1">
        <property type="nucleotide sequence ID" value="XM_012914243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X1"/>
    <dbReference type="STRING" id="5866.A0A061D9X1"/>
    <dbReference type="GeneID" id="24566052"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400070"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="291" mass="32105" checksum="D1F743D87A4CCD6D" modified="2014-09-03" version="1">MAAAQKTNKCVCYTNSCSHSSGGTCYVSTCTEYKSGCLPGCKGCEKMKCQDGKPCKCCTPLCGCQKDCYEDCSDNNCKGLDKNCERCKKKCERGKACICYRCSCGTQCNGFLCACCYYCNPGKCQSKGTCDGYVLGKCPEGMCKGHGTYDDDGRPVYVENCTCNNERIDFSCQCYKSKYDNKCRCIRGEPDGHGNCVAKCYMCGKLCSQHSYIHEGTIVVASLAVAMIIIIVCSRYRDKIRRVFYELSGSISRAPQLSSAYTNNLVGDKFPEEMNIDRYPAFRPMPYAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X3</accession>
    <name>A0A061D9X3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition motif domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0312010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769484.1">
        <property type="nucleotide sequence ID" value="XM_012914030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X3"/>
    <dbReference type="STRING" id="5866.A0A061D9X3"/>
    <dbReference type="GeneID" id="24565839"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312010"/>
    <dbReference type="OMA" id="NNIARMY"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053260">
        <property type="entry name" value="hnRNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48035">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48035:SF2">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="169"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="365" mass="40504" checksum="4D857F08A07C7F2B" modified="2014-09-03" version="1">MADQEVVAAEPVCEAPVAPASCEGVAATEEPAPETSSTDEPSNEASETPVEEPAQQESNESEQPEPQEEDQRASNKHSTPADDQVKFFVGGLHPSVDEEVIKGHFSKYGRIVSVQIMRDFSTGRSRGFGFITVVTQDNTEKVFTDDHILNGKRVDVRHMQQDPGSTIKRKIFVGGISKALSEQMLEDYFGRFGTIEKVIIMRQIDGSSRGFGFVVFAVDGAAEKVLESPSHFVYGSKVDVRAAETRSRQSSNRPDAYFKTLAQGMKVNGHDNIKGMPYPRSHHMQPPIMPPPSAAPVVGYDPQMLQQHMIYQQYAMQTQYAYYAQQGGAPGGRDPSRYLPHRPTNFGNQPYSQNNIARSYRPRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA18</accession>
    <name>A0A061DA18_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein transport protein Sec24C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0209080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767940.1">
        <property type="nucleotide sequence ID" value="XM_012912486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA18"/>
    <dbReference type="STRING" id="5866.A0A061DA18"/>
    <dbReference type="GeneID" id="24564295"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209080"/>
    <dbReference type="OMA" id="IRHDQTF"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="11">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="12">
        <location>
            <begin position="429"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="14">
        <location>
            <begin position="667"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="13">
        <location>
            <begin position="768"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR95754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113508" checksum="B4225F3245114AFB" modified="2014-09-03" version="1">MNPQGSRVDGPPPMGAADAKSPGASDNPQPPQVIRKIPTSEVMSVRVAMQDVPTAAVGGVGKHPGHHQHHVRKPAAPPPPPAKDQNTVAPPSGEPVKANPPEMVTRRRTSSDVSMASRLRSGSESYYIDRELEKVVFPYGAHTPKKTDYAKLPRPVSNIAEVNDEIGVDQISPMKSFLGQQAADVSVCSERFLSTTLREIPLFGETLGRIKIPLAAVVQPFAEEVDGKVPLVDLVSAIGEESLSKQNLIRCPRCQAYFNPAMEDDYRLNYRLCNFCYNGFMLSEAESNALTALKGRDLDNARVAPIMHGSVDFVAPLRYYVRDLGEDVTIAKQLTSLLSRASELTSMIPLLNNPMSPKKDVVYSTYDVKDLSQQFEGMGPTGHPHHEHLGGAADEPSSEAAAGAPAVSVLQTPASVPSAPQWKKDIVRKPAYVIVVDATANSAKMGLRNAVLQSMRSVFEECAASRTPVKFCVITFDSVVHLYSRRRGFFQVNVVYEVWDHFSPSCADELFIEFDGTNLEDVNSYLDGISRLEVPANASSSCGNFALSVGVSLLAEANTPGTVCIFYSQPPEMGLGYCHNPTVSSDFSMEESLKMFYDGIIQQCYESGIAVDVYLCASFERMPGDVCLQYVSQQTAGIGCSFPAFEAVSDAPKIVKNLVRLFSLPHAYNCELKLRCSKPIEVEESYCPFHNTRAFIDKATLRVPRLSPDTAICFALGMDDLIRDRERLFVQFACMYNSSVDGRKLVRVHTQSMKASTRVNAIIKGARCDTLVNYYARKMAYNMIRSGTDARKSIKEEVVAMLCSYRQLCAPSTPENQLILPENLQNLPAALNALFKMYNPGELVYDYLQKMLRTLLAPTGESKYSYTRCYCLHRSVYDEYAEGVPEGGWGFACLAVPSSATEIYSDGLYLIDDGHKLVLYFGPHVRWALLQELFGKDLLLNETTANTLSISSETETGRNLLDVISRVRALHVGGQFLHLKILPYCSRYRRLLKLLMLEDEAGGEANYEDFLVTMHRQIKLLQSYRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG1</accession>
    <name>A0A061DAG1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769724.1">
        <property type="nucleotide sequence ID" value="XM_012914270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG1"/>
    <dbReference type="STRING" id="5866.A0A061DAG1"/>
    <dbReference type="GeneID" id="24566079"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400300"/>
    <dbReference type="OMA" id="DAKEHWL"/>
    <dbReference type="OrthoDB" id="361131at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="642" mass="74627" checksum="0E2B0F1C0B52312C" modified="2014-09-03" version="1">MEEQCIYRHCSGYCNPFREASVVCLPVKLLSRQSLMRISRAYLIFNVFSVVNSFVYRVSTWNPATSILSPWRRQHFASTVDAEIKANDERCIPPLYARDKHVFDALNGAEGNDVGLVANAGDSNQAVLCDSLGESITGEGDPQDGDIMHESVYHNSSDESITFNRHPYRPKQDEVGNGKMSRRLWKLLMALLIYRSKYGDYAVDKSFKFSDADEPKLKGYNLGTELDALLSSIQLRERDEGLYNKLLLESQHKEPVFPACDTREAPHLLWLIGFPTVKYINDNEALRRQMAGARGMRKRISRFGTTKDMGLSRKELKEGTEGDPSRLEQVKKALIDDFEQSYQNECDRMYFNKTQVLPSPSNRAKIRPALLKGVISKLLELKQTKNPAILLRKPTRDDIEAGHHYAFYHWNFEDVIESMVLFNVGELIRNIAFLQDMYMDYNREILIDSVKHGKPFKPITFNILRPEWRVPKDYLWPERLWGLPLGLWLEKFRTGDIDAKQHWVRRDVLDYLQFDWGDGLKYLTFTWDKLVLGLLWYINFRGYPITDMDPHLVISNAELVAKWGKPEEIQGLKLGYIFYSAMDQIQVLKKHHPERYEFLTDMGISHVWHDDFDVSYRSIPHEKSTPMSRHIKVSKDSKYLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG4</accession>
    <name>A0A061DAG4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768065.1">
        <property type="nucleotide sequence ID" value="XM_012912611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG4"/>
    <dbReference type="GeneID" id="24564420"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210320"/>
    <dbReference type="OMA" id="GCKLQNE"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="118" mass="13346" checksum="288028DF991A1D19" modified="2014-09-03" version="1">MSRTGAPNIEVEVLKGLSQPSALHDELVRYILSTVGCKLHNESTLRLVSHAAQMALEKFIKDAKNMQMISKSMTEGKVGLLTLDEIRELDYQIIVETMQKTEPKAYNYSVFLEPNTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI7</accession>
    <name>A0A061DAI7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0210615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768095.1">
        <property type="nucleotide sequence ID" value="XM_012912641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI7"/>
    <dbReference type="GeneID" id="24564450"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210615"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210615"/>
    <dbReference type="OMA" id="SAVPKWC"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054716">
        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22543">
        <property type="entry name" value="Rieske_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="17891" checksum="1AD0A9012C9219DE" modified="2014-09-03" version="1">MRRRRTGFGGTLCVCARVILRSSRGVRGAWSSAAAKVGRHASIAIPCAVAVFQHGGRFLAIDANCYHAAGRLEEHGGDIEDVNGEPCIRCPMHKYIISLSSGHSFYEAVEVIRQPGGPPSFRSLGFKSKGVKQRCHHARVEGNRLLIRITRDGEVESDRYAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK3</accession>
    <name>A0A061DAK3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent Clp protease adaptor protein ClpS domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769907.1">
        <property type="nucleotide sequence ID" value="XM_012914453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAK3"/>
    <dbReference type="STRING" id="5866.A0A061DAK3"/>
    <dbReference type="GeneID" id="24566262"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402110"/>
    <dbReference type="OMA" id="EVNSWRV"/>
    <dbReference type="OrthoDB" id="5144at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ADAPTER PROTEIN CLPS1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473:SF17">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ADAPTER PROTEIN CLPS1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptor protein ClpS core" evidence="2">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="131" mass="14869" checksum="41922D12E868FCA6" modified="2014-09-03" version="1">MEASPEVAANMAMEKSNELEQSEEKKSKLEETIESIKETETTEQTDEAKKDRLEQIMAWKVVLFNDDIHSFKYVTEVLASSIPQLTREVAHTITVEAHNSGKATVICTWKSKAEFYCTAYAQVRNVDPLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAN6</accession>
    <name>A0A061DAN6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768155.1">
        <property type="nucleotide sequence ID" value="XM_012912701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAN6"/>
    <dbReference type="GeneID" id="24564510"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211160"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7600" checksum="55BD3843C5743299" modified="2014-09-03" version="1">MSKDSNNNADMPGAVIAFLSLFLMLVGMAVVTMIYHGIWPFEKIHNELYGVSDISDPYERFPAKDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV2</accession>
    <name>A0A061DAV2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769308.1">
        <property type="nucleotide sequence ID" value="XM_012913854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAV2"/>
    <dbReference type="STRING" id="5866.A0A061DAV2"/>
    <dbReference type="GeneID" id="24565663"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310250"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1279" mass="142218" checksum="ABA62C4CEB540DE0" modified="2014-09-03" version="1">MAAKVRVPEFKTLKECLEFLEWLKNDRGMQGQVANRLERLLKDRYKEAKQGGIENALSRFVGHASEFYKKLCTKASATYNSHVSATTVLKSLIVCIPKLLSAIYFLRYKVDANFKALGGGEWAEQEVGVVAMYARIPALLESNATKIDKYLITKHGSTQYGVIPGGFEAIELRAGFRGGYNPGSAMANDLTKICEKEKAQFFRDVFVTSVFGNDGANSANVANAVRLVEDFGRIFGNVTKDDDFKSHLQSNRMCIDWQALEAHCAKLKTSLEKIFKTNGFSFTGYGRTVGEVKKENVAKKMATWLKKHLIEIRTNLAHIKPFDNRKYKLDDRRLRKGNKLPAEFSQAFVDYFTENFFRYGFTFGKNKYEMSDTPYQDLLESWNAALVELKRMTGDLDQLKTILDGNQCPDRNRNKQPKSKPEPNPELEPALLDVDDDENDLESESDFDDLNSESEDDDMPPTKTEASKLSSTTNVDTTPQNNKSEGAQNQGKKAEGNQNQGNDHSVANTSISPVSQAVRTQSSSVQSPDSGSPGATGPSSGPGPGGQADVSDAGQPGVQKAQANGDANGTASNTPGAGPGGSGTGGNGKSDNGQQTNEYQEGINRLKIRHEEKMKEAQKNMERLEDAMQKLAEKKAERQKKLDAQGMNAGYRSYYDPKASDRRAQYFTDLQMTPVIMDGADVSNEALRNPGIEWERNHRDEWKLAEQFRKEAEKREKQKFRRNLRDTQEKVLNRLKDSWLHQEFHDDDIGHVVPHRSAVDDRTIMNPPPPNISFKISKPFNAKTIYDEQSLTLPHPNIELEIDKTYDRRKKMNTYNQKVFYTEGEIIEPKPPTISPPIIETGPFGSKVADPNVDTSKMLPDDLIPKLPPDTLDVEIIHRYIPPPNDIIIPDIPDYVLADSAGSQVLNDHTAPTAPTDKEYDGKGIHSKNEIKTVNIGVNPAFEVIDDGLVIGKIDPPSQPVEAVDLQIDVPKPTLQDSSYDIDLEYDHPPLPQIEPVDPIGSVTPAIKINLAPPEALPDLPNNTAAAYVYSPSTVGMCISSWTTSKPTDHLDIPETELSPSQAPRTVRDMLTWLAGLRNPKHHKTLKLCINRAFNGLHNESSDLALSINHTNIRPNDVFDILQLTAMFAGSVLTAISPTWKANVPSRTVKPQSSNESQKPDCCALLCQLRDYAYACCHQLEFLKAQCNRDKLSGGWGNYEYGSDIKTPSPLQAFLTDGWDSTFKTHPFDPCNLCHKSRVRMGFKREDLPETSQLGSVISTILTPSCGGEERDALVNTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB43</accession>
    <name>A0A061DB43_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768320.1">
        <property type="nucleotide sequence ID" value="XM_012912866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB43"/>
    <dbReference type="STRING" id="5866.A0A061DB43"/>
    <dbReference type="GeneID" id="24564675"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300390"/>
    <dbReference type="OMA" id="QEFATNI"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="673" mass="76615" checksum="2F859EC9BD8822A1" modified="2014-09-03" version="1">MRDAREDDAMDLDPVEDDPVVCEFDVFVNNTVLQDLLGRIAEPAKTISVASELCSKPFGDLFLLQYPLELSTSDCPNASKDVDIQNRIALSSNATDMLPLSTLSIGKESKREVVDERTYGVASIIKKTKRSSCPYLKFVYDLGTKYPVNVMSLSAKKSSRASSPFLRYEPSDLTNTIHLFDLSKPVSADKKKTLKLRSEIVTGDHVSDCLGVLVVEETDSGLVRSLHIVPVRGVIQLRPKVKPYMSEIVNFDDTLNSLFQNRNLQWRDVGKISEMDSAESREIVQMLTQRCRTLQQLARRPIYFHENPSMYINAVCFAQEYGKYQDEWHRSLESDVDGYQHSTNPAFSTDNGQIAYRCMHENTPNVRFMGTLDVRTQLKLLLTQRYIDSFYALKKDIIAGPEVSDDQLIVMLQEFATNIDGNWILSSEHAIPNYTTEDDFDDEDRAYLIVCRDVILGLFYRDVVMRDLLQKGAYGHVTIEAVHSLTGLPVRMVHEMISQVAMQHGKLWTLKLKRDSEFYNKYGALMKTYQVNWSNRLLESMKHVKTLRETQSSKVSQIIYRYILKGAIISALKNRVYSAEQISQELTAQGYSIDSAPVFESLLKQVAIPFLRGDRKMWVLKKSHVSLNSLKMVLSGQNHPGTRRLTSDEVRRTLQDSALPGFLKRRISMMPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB83</accession>
    <name>A0A061DB83_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IMPORTIN 7, 8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0311400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769423.1">
        <property type="nucleotide sequence ID" value="XM_012913969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB83"/>
    <dbReference type="STRING" id="5866.A0A061DB83"/>
    <dbReference type="GeneID" id="24565778"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311400"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="953"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="961"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115150" checksum="17EEBD4448EDB6FB" modified="2014-09-03" version="1">MAAEILLMPESLHRALEGSLSPDQALRQESEEYLYKISTAKGAIPLLLSLISADAVEAPIRLAGAVKLKNIVITHWRDSSVLCAEDRAALWKGIYNAILSVGRENDLIRRQCFEALRHIVFNAEQADVSYIAQRVKTDIEQRSNGDTLLCALKALRKLMYRYEYHAQSMTDEVNAVVDGFFGHLLQVAQDASNAGLESPEAAECIHQVLKVYFSLALLTSPTTETVQSTLQSWMALVQFVLDNPVRWDAVFKTGEHAMMPYVELPDDEESRLHEMPRFKCLKWAIQILTKYMSRQTPQKIEKDEGKMHYVRYLKDGYAALFAKKLVLLLQAEASGGAVFTNNLHHRMWTYLKYTLPLTDVYNASMQPCAAVIVQMIFQTFACNAYDEQKYLEDPESYIQNSPDVSFQLMSPRGTAADFIKDACKFCRADFAPIIISAARDVFRDRGNSVPELYGIMCLVGHTVAGVLQNSKKGKKKMGSGMADMPAEQLLDGEAFITTFVAPLLSSPDKWLRMRAAWLCGHVVRTIHPWRDSQTLLTLYSRLVELLGDQEVIVSVMATGAVLAFFHSSDETLQRTIVEYLPVLLQNLFKLMERVELETVVSTLDEVVDRYSVAVLPFGAQITENVCNALWNSVGNEGVVDKHDEDTSNDEQILARWSMVQTLTSIVRLAAEADTKTMTPNDCEMFAKIAHRTGTLLISLYEHLDLDTLMDYIDDLAMLLSYSVKIIHKVVGYAGEEKAALMGARFADMWKILGLCTKAISGYHANDSEDGDTIQAVMVEISVIRGPVRSLLAYAPNGFTFDIAMQLYALCQKSFDGDDGTHAERLLADVFEVTYNTRACDSILAVAAKELTKGIAETYEAIMNTPTYFQSKIRYAAVVVMYSCRENPPLKSLEDPDTLIKVLLHVSRGCTSKYMCKLYLACFSSLKQNVARYSQDENVQRAIDELLLEAHNVNNGSRMNPELDDMDEEDSDFYTDDDDDYDYESDDDDYDDSYDDDDEFDDGCSPLDNCNYADMCFRVAANKPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBK3</accession>
    <name>A0A061DBK3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonucleases domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0301830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768465.1">
        <property type="nucleotide sequence ID" value="XM_012913011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBK3"/>
    <dbReference type="STRING" id="5866.A0A061DBK3"/>
    <dbReference type="GeneID" id="24564820"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301830"/>
    <dbReference type="OMA" id="IFRNGYR"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="34"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="495"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="557" mass="63020" checksum="0042A8C9DF7F2614" modified="2014-09-03" version="1">MSTSSAGGGTAVPFGGTVPGDIAMLEMVNVKKLLQSRCVEIEELFTTLKHGDKQDRVFQRLPFALRRRAMSHNPFRVPKRLRLHLAREMAKSMPKCAKRLRKDARRRLNRLEEYRTRCERNNWLETHMYHAKRFKMERLWGYRIAIRTTQKCRRRCLRNSSRRCVIHDLSYVLVVSVSGCMSALRRAFKNMFADSSIMFQSRLIRGEYRSQAFAYTNTGDNYRMICPVQFVWITPSATAAVSVSVSDQGGEYREVWFFVHPASIDEFMETAKTSDAEVACRLVKDLCTFEVLGPLSALLLRRTLKVDGCLTTGNSQWTHLDPGNCDIPPSYILPLRVMPPVVHGNSRPSFKFETMRGQNFKSQQFAAAAVCADERSHLTTFKKPEDFAIVTKVNVPRLRRRNYGQLVSKLLDTLSVRYPSESPALTSDPTASSTANADVTMDAHADTGHTNVASSQDHVSDIKKPSKTTQAARTDYDDASSVPIWIIRRGDSIGGFDVVMPAGTISRKLWILLNRYGALGIGLQEREMLYAQHGQCMFPQDYPETLAGHQLMEAQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBS1</accession>
    <name>A0A061DBS1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide chain release factor 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767386.1">
        <property type="nucleotide sequence ID" value="XM_012911932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBS1"/>
    <dbReference type="STRING" id="5866.A0A061DBS1"/>
    <dbReference type="GeneID" id="24563741"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203570"/>
    <dbReference type="OMA" id="HRMVRNS"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43116:SF3">
        <property type="entry name" value="CLASS I PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43116">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595991" evidence="2">
        <location>
            <begin position="17"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="3">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="329" mass="37668" checksum="0F414B42B779A8FC" modified="2014-09-03" version="1">MLLLALLPLVFRESLSMSTSIIAPLFRRELRLALPLSGRWLQDPGLSFLSRAPLATRATRPAAKSTANSGSTLDLCQYDRNDCRVTITAGVGGTEAFDFCKILGRMYKRFIHHYSPPDSWDRDRYGDLPKSLRYVECDAVPGDKVGYRMLEFEVQGEYAYKLFKGEKGTHRLVRNSPYNAMRKRQTTFSSVQVVPMLSESDQDVQRYHSSRQVTDRDVTVETMRSGGKGGQNVNKVETAVRVTHKKTGLSVRVQTERSQAQNREIAMKRLGEMVDAHYKDQLREKCEELRGEEVDADWGKHMRSYILNPEQRFKDHRTDWETAECSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBT0</accession>
    <name>A0A061DBT0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769608.1">
        <property type="nucleotide sequence ID" value="XM_012914154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBT0"/>
    <dbReference type="STRING" id="5866.A0A061DBT0"/>
    <dbReference type="GeneID" id="24565963"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313240"/>
    <dbReference type="OMA" id="ETWLNMD"/>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="2">
        <location>
            <begin position="589"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1205" mass="132002" checksum="55A388C45EADC46E" modified="2014-09-03" version="1">MSTRSATKAGTPAPMDLHGEFLSNCNDEGEAPSVAGSTHSASIRFVNKAKSSGSKDRFRHGEFTEGDMYSAKPVWQQLNEIESTWNMQFRRKGRVESQRAITKAKKCVEALDAVEANDSRLVNIDSFREVGGVDRNDATAPAEFLSSVTHRAPPSPDQKSGPPDIHPASNPNTKRMQSVVGDGYKNAPVRVGKGGAAAPATAGTSLSGNRWMDRGHASSTVPPGGLLVNDLHLPGDQYYEAVSLDDDGSKGISVSAKELNLSPEEEKLRASLAPSVLFDHLLNDSERSVVEGIFGNKPGVIDAATPAAVIESETKLEPETWLNMNPAHIVLQQSILKCRSSSQILIAIGDKLDKLNAVNASTALHRLARHTTSYSRYSLTSNETFTRLLAVLERHLLDLDSQGLTNVLWSLVRLGVQPNWLDALLATLNNHANDLTPSELASCLFAMSKLPVKTATSVDLRDRVIALAQERVSHFKRPLDLTCIATALARLNVRNPVLFGRISSSVLAVVNDFTLQQLCGIAWSFASLGFTDRALFARIRQFLEEHAGAGNMHDVVHLAWALSKVREADREVFLCTISPLVRAHVSHLTCRDITTVAWAFVNAEIDDPDLFEDLACALQHHVDEMGTHDVAAAVAAFAHMEESHKALFKKMRNRALLMASEFTPLQLAKIVRGFSSVADERFYGQLCRSIEGKVHLMLPENVVEVLMGLTEAGHVPPALLKQLLTAVSSGVRKMYAEDCLLLFQVALRLKRDCTERATISTLDKLQHALVEQIEARVGRWKCYNISHITSYFECLSGMGIGGSKGDSSVRILSKQLSACLNRLGTAKLPTSERNHAFGSFISACASLPPRKLAVFQAELSKSPELMASMHNCVAALRSGDYLASESSPISRTDACYCLVRMGYLDDGVVSLCDELVESYSDPDELDLSDPKTLDHLSKTIWLLMECNLHVAWVRDRLRAVSESQFTPSASDSLIRLLWSCAVLGEDALLMSMLPRFVPVFERLPEDMLSAQQVALHVLRCLPVDTDTSNGHSKLEPGDPNNSQSNAVVSCTGERYLISSEVHNTLVEWLDYQRDDLFTVTPGSRKKRALELDYDAVLSETLVSMKIPHKTVHTVANVYRVSVSFPMENHVLDVLSFTDCFVPHGQPRSRALLRQRQLQLLGYGVASVNLGHVYAASREGSCKPLVAKAISGFVETAADYLPAAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBX3</accession>
    <name>A0A061DBX3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L23, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0302930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768575.1">
        <property type="nucleotide sequence ID" value="XM_012913121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBX3"/>
    <dbReference type="STRING" id="5866.A0A061DBX3"/>
    <dbReference type="GeneID" id="24564930"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302930"/>
    <dbReference type="OMA" id="RLDHHKV"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_uL23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="154" mass="17401" checksum="7A30F57980DE053F" modified="2014-09-03" version="1">MGLPEVAKKGTEAEKVKKAKIAANSVKKATTAKGYKIRRNTHFFRGRTLALPRTPKYRRNHRTALSKKLDKFSIIKYPLTTEKSMKMIEEINTLVFIVDSRANKKKIAKAVTDLYDVKCVRVNTLNRPDGLKKAYVKLSPDQDALDVANKIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ8</accession>
    <name>A0A061DBZ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767466.1">
        <property type="nucleotide sequence ID" value="XM_012912012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBZ8"/>
    <dbReference type="GeneID" id="24563821"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204380"/>
    <dbReference type="OMA" id="AICINNG"/>
    <dbReference type="OrthoDB" id="347083at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058332">
        <property type="entry name" value="DUF8019"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42535:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_146, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42535">
        <property type="entry name" value="OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26058">
        <property type="entry name" value="DUF8019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595668" evidence="1">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8019" evidence="2">
        <location>
            <begin position="258"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="341" mass="36816" checksum="2E695D0F7F4D0B46" modified="2014-09-03" version="1">MVGTLWLCAALCSSLCIGLAFEGCDVVVDSSICIKDGATVLLPSARRDGRVLHYRFDEEVAVDSSGFGNHGVGPVAGHSGFSGVGSSAYFRKNFVYLPDTKSLRSNEFSVALFVFFLKDEESAASADKVNDYCPLVHKGIRTAALSECAPEIAVNPKDGRVRVLLSVESSQTMEVESNCRLQPHQWYHIAVVKDKSSLTLYINAYVRYNPLPLYVGASPYMGKCDMPVLIDELSFYTKALGRDEVQAEASAVLGGVEPSYVAIGCINCGKEEAMKSCPQGYHLCNKFELYTGMYKTTLWFMPVSGGYGAALRLSIPANRIMAAASAEPSTGVALCCANLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC20</accession>
    <name>A0A061DC20_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769733.1">
        <property type="nucleotide sequence ID" value="XM_012914279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC20"/>
    <dbReference type="GeneID" id="24566088"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400390"/>
    <dbReference type="OMA" id="APVNCKM"/>
    <dbReference type="OrthoDB" id="360958at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005405855" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23670" checksum="4A8770597B31E27E" modified="2014-09-03" version="1">MPIPLKFPTLLVVFSYVSSVCATESTDSGKAPLESFNQLMERSVVPLAIAKIFSLNDRHDTRVCVLNNVFANYQDTPQQCKCSFTRLRDIELQCANNPLGGLHDCSKKICETCCIISMTASYTEDDRHHNYPVNCKTRCLNSPITSDVTEDSQQFLSELLLKVNALYHADVSTAKQPGERPTSPICIFVSDTANVPTQYHVVHLEDQHDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA7</accession>
    <name>A0A061DCA7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0305070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768790.1">
        <property type="nucleotide sequence ID" value="XM_012913336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCA7"/>
    <dbReference type="STRING" id="5866.A0A061DCA7"/>
    <dbReference type="GeneID" id="24565145"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305070"/>
    <dbReference type="OMA" id="GQKTVCA"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="516"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="258"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="682"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="778"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="862"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1214" mass="136147" checksum="D32C145E016E9AD4" modified="2014-09-03" version="1">MHIKEVGIRGFRTYRDPCVFRFCPGYNVIVGLNGSGKSNVLLAVSFALAETLEHANRSCYLYRGAESSEDDDFTAHVEVVFDVSRDVNIQSVIDNKDELRLKRIFSRSKDLYLVNGRQMSRKDYRQLIESVKLIHFSKQSASYRNDLHFIVKQGAIGKICSLSSEERLAAFRDVIGHRSFDSKIEESMKLLKDYDVTFSSVDAQLSQIQRKLDTLDIQRGASEEWSKLDAERRVLQASLVLLKLSQLRENASAQETAESELSAKINELQGRVDLLEMDVRESRGALSIIESAEEAGTANAELSSLESSLADVEAESAELRKELGLLTHTKGQLERELDTLNTSLESSVAELAGVENDHVKASRRIQDLETQLSDVMHRQHSSDEKVKELIERLEQRKSEARESIKEFESQKATLSSSLTRCMNDQELLHSEIAKLKDLCADKAARMEECTASLETSLETKRIKQNELSASAAKQSNLRVQYSDADKNFSKVALSQKTTLGLVKDWLDSDDSAPHRDSYVGVLIDLVTVSDAFKLAVEQTLGPKLFTVVVRTMKCAKSLISHIEKSESRYSNIRIVPLDIFPKSIDINDMHLPNSVDRAEAMPLMDCLTFDDHLKPLIRSLLGDFCLVENADVASRISGNRVNCVTPDGQVFYHRGSVSGGYVDMKESILRLYDIMKQAGADLAAEDEHVARLQSDLESLGEEQTKLAQQRNVFKSERASLQENLRQLQISLQHLTSLEDSIRHKLSDNSTERLLYQIKSWDEQIEVYKRAATPSPAALAELASRQSSLESELVALRRQKCTLESRAHELRDNVSVLQDKRNALAKRVITTLQLLEDYSGHLRDLEQRSASLTQSRDSIGSEILKASEEREKSQRQLDELCSRIHKLETELASQKAALAEATAQLRDTSQTLSSIKISIKESEDELSRLDQAVLEEAKQTPVYNKDDLMSRLAEINKRCSKFDLSVRGCSQDSAALRAEFKELRQRQERISRSNAAILKSIRALKSQKDSNLVQMLSQLNDKLSQTFEELVPGGRIRAVLLRRELATSEPLAHVAVCLPECFVESPDEEKFTGLDLKVSFSAGSDGMQQLYQLSGGQKTLVSLAFILAAQRLQAAPFYLLDEIDAALDEGYRVNVSRLLERQCREGSQCILTTFRYVARIDLLLCVHSPELLHPGEVFYEVCNEGGVSVAHRVGLDDAMSVISRCTLAITNGPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE9</accession>
    <name>A0A061DCE9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767701.1">
        <property type="nucleotide sequence ID" value="XM_012912247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE9"/>
    <dbReference type="GeneID" id="24564056"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206730"/>
    <dbReference type="OMA" id="FRILRFY"/>
    <dbReference type="OrthoDB" id="10370400at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600267" evidence="1">
        <location>
            <begin position="18"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="612" mass="67487" checksum="854423BF2EA69FFA" modified="2014-09-03" version="1">MQVLWLLPIVHLGICYAQQPEPQLQGAADAPPAVVPPQTIPEEPASITLDVAELTAIPTPANTPASEELCRGHVKAVHMVRLQSMIMLFEMKHTLLNNLRSEIGDGFIYPFTSSLEKNQKTAIQDQRKDVDAKSKTYANAGLTEPNGTSYYASTEALYTALNAANTMLDNMHINNVLYIKQAWGEKDAYAAMKTLIQFDIQLYAKKVELAYKTVSDSVKLQTDPAESNDARSNILNAHKTIRSAATYVSSVGNDAQQLPLSFVKYLDAKKVHDSAFSYARGIVTSVNTACQRHMPTERRDTNVVIGDITAAKDAKEYMRLVPKRAVGDATTVQSWLKTAAFFRYIYALAVIRMSKTCHTLVAFLVTKVPSSDTEGFTNMYNAIQRDALAYITAMSAYVADVANAQMSTNHDSAAATMVTSAEEFIKQYMETVKTLVSALGDNDKVAGENEVLRADTEILRTAVAFLARMMRLYKMDMVDDPMVMEPAPYTSTISMLDRTIAMADGTKEFVAARMAAPDAMKSTIRSINVLKEMVKDAFDTTMSHNEVYRTFYPQGIDDADRHMKIFKDLESITNAQVFFALKPEETEDSGKESSGFVLPGALLAAASALMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF3</accession>
    <name>A0A061DCF3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769948.1">
        <property type="nucleotide sequence ID" value="XM_012914494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF3"/>
    <dbReference type="GeneID" id="24566303"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402500"/>
    <dbReference type="OMA" id="LMHYLGC"/>
    <dbReference type="OrthoDB" id="10410663at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="113" mass="12042" checksum="0A0D7F2809F2732B" modified="2014-09-03" version="1">MGLLFGGCLVGERYRRSDPALSKSIIIGEIHLLSSYLAFTCGLRSGLMHYLGCGIIPISSVSGVLAAAFVSGNADVAERTVLHILGGCFAVCAGNEMLAARFNMSPRWYAPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCG5</accession>
    <name>A0A061DCG5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767731.1">
        <property type="nucleotide sequence ID" value="XM_012912277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCG5"/>
    <dbReference type="GeneID" id="24564086"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207030"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="73" mass="8310" checksum="8547B36A55D520EB" modified="2014-09-03" version="1">MDVVKADCDSQSGMKCQKHDESLRYVVGMRWLGNTFGNPQLNKESGPITLEIHRVALDYVVLREPHKHMANQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCI4</accession>
    <name>A0A061DCI4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767776.1">
        <property type="nucleotide sequence ID" value="XM_012912322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCI4"/>
    <dbReference type="GeneID" id="24564131"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207450"/>
    <dbReference type="OrthoDB" id="10293966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28190" checksum="DD98575B4B828F97" modified="2014-09-03" version="1">MAYHSLSEAPRNVKECIDWLMALKGTDAESNIAALGAALHDFLADKPVGLTVLPALENVKLISREFLEKPELKDQWCVVRVLDKFKEPMDKNPNVFYKFFGTVGESDYQNVVQTHGVDAEAMTAKITQVVDNCEMFLNYVRDGEYYTPSYSSAATWETSCSQDPEACAVVFVGFAPMLYTGLLSLLESSIVACFKWPPFSADKPMGEVLKAVGFEEPGCRSGIKASNVLRAFKYLDEEVFASLYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ0</accession>
    <name>A0A061DCJ0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0402900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769988.1">
        <property type="nucleotide sequence ID" value="XM_012914534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ0"/>
    <dbReference type="GeneID" id="24566343"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402900"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="146" mass="16399" checksum="83A824E536BEF87D" modified="2014-09-03" version="1">MRDLRHPVAVVVTDPYMQGCGVTYESDEMFKPETPKRYDAHEKPNIGCKIDIHAAKEAAFYCPAPYVLDPPDCFYQVYVVAEVKNVIDIALLLIALAFQHFVAVRINGQLVRGDEMLHQTPPLECRCVTIKGIVLSTIQIGNYCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL7</accession>
    <name>A0A061DCL7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768965.1">
        <property type="nucleotide sequence ID" value="XM_012913511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCL7"/>
    <dbReference type="GeneID" id="24565320"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306830"/>
    <dbReference type="OrthoDB" id="10620938at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="20829" checksum="E3E5953A5124DB6F" modified="2014-09-03" version="1">MMDKHDSGVTNGTDQDPAAHKRPADALLGDPETTALAPTRTLKTQGGVRVYTHQPSSGLEKKSVHIDRPETTSSELDARLEAGSLNKTAEETPTAIIDIPKERFDICIQTADPCPQLIEDNSATEHATSPNDELGLPALSELPNDIREVLEAVSSTLEELSQAVKRLESTQKVILRRVKRKSSYNQFFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCV0</accession>
    <name>A0A061DCV0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770203.1">
        <property type="nucleotide sequence ID" value="XM_012914749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCV0"/>
    <dbReference type="GeneID" id="24566558"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405020"/>
    <dbReference type="OMA" id="INIPAMF"/>
    <dbReference type="OrthoDB" id="10393183at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="149" mass="16768" checksum="9971E7DD3F58C22A" modified="2014-09-03" version="1">MGWRVVERNPTINIPAMFPRLGDDKEIRRQLETNLGLDSAVVTNTDDDVQGELEALEGESDQRQRRRIGVGFKPEKVRVFSAEESKLKEVIKGKQSASKSKRLKTAVKQASKPADDEDDEPSRLDLILSASSNLKAERRKLRAKRLGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD39</accession>
    <name>A0A061DD39_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0210750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768111.1">
        <property type="nucleotide sequence ID" value="XM_012912657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD39"/>
    <dbReference type="STRING" id="5866.A0A061DD39"/>
    <dbReference type="GeneID" id="24564466"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210750"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="77"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="179" mass="19690" checksum="C777E756990A005E" modified="2014-09-03" version="1">MAIRPAAPPASIIGINWSPADLSYESAQACDSSKYFEYVRCARLSSPSVAKSTAFLQNMDDHQIAAWVEQQAHQNKVVVFSRTTCPYCVKANGILMSEVPSDVTVVQLDDHPDRPAIMEYFRTTTGAATVPRVFINGKFFGDCSKTVCANILLRHHVQVAAQQSGELRKVLLEAGCRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE9</accession>
    <name>A0A061DDE9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768406.1">
        <property type="nucleotide sequence ID" value="XM_012912952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDE9"/>
    <dbReference type="GeneID" id="24564761"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301250"/>
    <dbReference type="OMA" id="QWRNSEN"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="21359" checksum="E8CB66D8EB9E045E" modified="2014-09-03" version="1">MGDHCDPNSEITLIKVPKFLANHWRESENQSYMGYLKKNDDGTIDELLVKFEGKQRRFLSRANHLSCPMAVQIRDANAPIESMGRFKRSLTIYPKLDSLYKSEIKERHIVTNIHKARGTAHEARSEPNNDRSATLFKYYNPNAEGASTIAHGAGADYVPSKQDTPYSRSKTKGNLSYPSIVSVGIDAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDR4</accession>
    <name>A0A061DDR4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769815.1">
        <property type="nucleotide sequence ID" value="XM_012914361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDR4"/>
    <dbReference type="GeneID" id="24566170"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401210"/>
    <dbReference type="OMA" id="QYRGRFE"/>
    <dbReference type="OrthoDB" id="363224at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056347">
        <property type="entry name" value="Microp_apicomplexa_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23512">
        <property type="entry name" value="Microp_apicomplexa_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="93" mass="11218" checksum="BAE66FB95993EF0C" modified="2014-09-03" version="1">MFALVFSRGFATHNNSVSILQQHYNRLPIRKKFIRAIKRGTLVWDRGQVKIPPLHCEGYDPPRQCLLPNERHRRRQYRGRFEHLQSKRVSFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDY3</accession>
    <name>A0A061DDY3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0305890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768871.1">
        <property type="nucleotide sequence ID" value="XM_012913417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDY3"/>
    <dbReference type="STRING" id="5866.A0A061DDY3"/>
    <dbReference type="GeneID" id="24565226"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305890"/>
    <dbReference type="OMA" id="NIGMNFK"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="10">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="145" mass="16054" checksum="01DBA51B07846635" modified="2014-09-03" version="1">MAVGANWDDIPDDFVLPAGNAKRGAKLFKKHCQQCHSMRPDNRQTSGFATVGPTLFNVYCRTAGVAGHDSVTGITDTLQNAGIVWTDANLMRYMKNPERFVSAVVGMNFAGLPNFQDRVDIVHFLRDLTPEGEVGQKILKECKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE14</accession>
    <name>A0A061DE14_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6832 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770055.1">
        <property type="nucleotide sequence ID" value="XM_012914601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE14"/>
    <dbReference type="GeneID" id="24566410"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403570"/>
    <dbReference type="OMA" id="FLTKEYY"/>
    <dbReference type="OrthoDB" id="429842at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049235">
        <property type="entry name" value="DUF6832"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20724">
        <property type="entry name" value="DUF6831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20725">
        <property type="entry name" value="DUF6832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6832" evidence="1">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="469" mass="53801" checksum="E85B0117574DB07C" modified="2014-09-03" version="1">MLGLSRSFRALQSAVATGQVATREYLESFEPRSLRRLKVFDSTPPDDIRRVYFERLTANYSNPRSILNYIAVDDYPCYSWLVRCLCQLGNAFSFNSFWSPKDRQSLVSLPLFKYLIYDLIERKRYLQPRHAPRVLFALTALDYRCWPLISEILSLVERNLDNWRLPTLGCMIFCCVYLGLHNTPVGSIARVGGGATSGNNIVDVLFNEVLRRDPSDAKPFDWALLSYSLVLTNRYEWPSNSTSALPVFLERACEHLTLETLPLSGWTQYILYLTLYCTDVERPMNEIAIKSSVPFMFQESLHVRWLNEILVHAQPQGSEQLQKDVDSVLEGLGITEGLINCSIGREDDEQHCLFAGHVFPNRRLCLEYNYMKGLPSGEPVEGGLISFRHRIFRKCGYSVAVIHGNQWDGLSLAEKEEQLMRILSAFPELPGETYESKPEPLSFEEHAGIKHMKHVRPQMTSWPPEKIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE23</accession>
    <name>A0A061DE23_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770085.1">
        <property type="nucleotide sequence ID" value="XM_012914631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE23"/>
    <dbReference type="GeneID" id="24566440"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403870"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="65" mass="7176" checksum="2460018C345ABE14" modified="2014-09-03" version="1">MSRQQEATPGDQAVSASVREESTNVAKESFVAKDVHQDDSKVLYSCIDAEDEPYKYALMCAPTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE31</accession>
    <name>A0A061DE31_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0404120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770110.1">
        <property type="nucleotide sequence ID" value="XM_012914656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE31"/>
    <dbReference type="STRING" id="5866.A0A061DE31"/>
    <dbReference type="GeneID" id="24566465"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404120"/>
    <dbReference type="OMA" id="CPVVDSH"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10289">
        <property type="entry name" value="GST_C_AaRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="13">
        <location>
            <begin position="53"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="729" mass="82797" checksum="9385A9A8E7468A3A" modified="2014-09-03" version="1">MAETTRDAVTVVHAPRETPYGAIVLAAIAKRFSKANESPIAFEAGKAIEPGTYLLEKAKLQEPQLLRELCLRIPSCKRMLYIDSSASLDQWINYVTLHSATPKTPVADLWQYYNKMNTHLATRTFLIGYRMTVVDVLQFAALSNAKAVCKELAKVPHVQRWYNYIIAIPGVQQAVSDIQRKNVPQVEKKPFTKEQQIDNSYKGAVTGCTKRTEYADALKNAEQGKVVVRFAPEPSGYLHIGHTKAALLNDYFAKQYNGKLLLRFDDTNPVKEKLEYEETIKEDLQTLGVAFSSTSYTSDYFELMQDYAFKLIKSDLAYCDDTDVNTMRHQRTEGIESACRNLSVETNIANFEEMLKGSEKGMTYCLRAKIDMTHTNKCLRDPVIYRCIADAHHNRQGDKYKAFPTYDFACPIVDSIEGVTHALRSNEYSARIPQYNWFIEKCQLRPVEIYEFSRLNFVKTILSKRKLQWFVDNGVVNGWDDPRMPTVRGIMRKGLTLKALLEFILELGPSKAVNLMEWDKLWAKNKQVIDPIVPRFAAVGVDAVELKLDNFNDVTLPPAKRNLHPKDPSMGECDLWFAPTVLLDRVDADEIADGEEITLMRWGNAIVSTPSLHAQLNPDGDFRKTKKKLHWLPKDDDKLVKCTLKQYGDILAVDKIDPEQLAEPDDMRNFLEPVTEWSTPCLADRQLAALPRGSIVQLERRGYYIVDQIAAEGGLILISIPDGKMKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE67</accession>
    <name>A0A061DE67_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769056.1">
        <property type="nucleotide sequence ID" value="XM_012913602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE67"/>
    <dbReference type="GeneID" id="24565411"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307740"/>
    <dbReference type="OMA" id="HEGIAYN"/>
    <dbReference type="OrthoDB" id="364810at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="489" mass="54912" checksum="167ECF3ECD6065E4" modified="2014-09-03" version="1">METAKYPFARAAPSVASAQPVVKRDGDIKQPKAGTTPLKFRSFQDFYLTQGKTHNRNFLTANKGERSPWKCQISHTPNNAVTSMADNDATLPGMYKTYNEEELSKALKGHVKRLCDYFQNGTPNKNYTNTIKAMVAKTKPRQPTQSSRSDSSCSTANSVKQNDGVPTLPLAERLSAPAVGIIELAQHIASRRQEGKRPTTNQEALEFLESEGIAYNNAVMVMGHDRSRGRSRQVFNWKTAMKAMCTGTDVPDTPDSSILDRDEVVRVDLPLPLDPEMREFLRKRGFVIGEDGMPITADDDVVECNGVQFYVLPHEGSVTRRESSADAPVSQPREVWADLKTGAVLPEVSHDPHKFESYDLRITKETTEPDASLGTDEEEFESARRKTEEDAFFDKTDYNLEDFTNHMFGHADLENINQVIKHIRDILPEECDGEIVDVAELSTDRREKNAEGFGWFLDKAQDSQGDDLDEALEELAESFERRLSIRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEQ6</accession>
    <name>A0A061DEQ6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase Rpb7-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0401860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769881.1">
        <property type="nucleotide sequence ID" value="XM_012914427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEQ6"/>
    <dbReference type="STRING" id="5866.A0A061DEQ6"/>
    <dbReference type="GeneID" id="24566236"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401860"/>
    <dbReference type="OMA" id="WISCGDI"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="25316" checksum="1C2B25917AB399B6" modified="2014-09-03" version="1">MAQLPWSVVTARPVTFGKARLAAEKCSQGIAQQIDNKPLKMRLTSMLQAFAEAMQECENSEELRNVTSHVPGMSMVKAKGVVQIHPSFLGNALKGVYTYLSNFLMQYNEELGGIWLTCGKIRQQDECGYVTDGDCFGVLSLSVTLKMVVFYPFSRSVIGKVARVSAHRASLLVYGIFGVTVRSVDEASEEHHELTEGSLVDVEVDDVKILPKNKWVMLATAVERVKLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEY5</accession>
    <name>A0A061DEY5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0405740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770276.1">
        <property type="nucleotide sequence ID" value="XM_012914822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEY5"/>
    <dbReference type="GeneID" id="24566631"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405740"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="2">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR98090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="166" mass="18837" checksum="35F4B5F7FC341D93" modified="2014-09-03" version="1">MESQKAYVIVRFIDCGLMYYVYNYCEFYCLELMNQVTQCVLNTMTHIAVIAVSIITFKNHAEVMGNVGMGAAIVACLLYWLAKQSFCASWNEVTAVYLRSLPARRQQRVVVEKRSPVSGISSAPPGYLIAHSNTPHVDIRYNVLVCVAYTWSRRFHKMLRPNAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C0A1J0</accession>
    <name>C0A1J0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Cysteine protease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CP2</name>
        <name evidence="9" type="ORF">BBBOND_0400360</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>Characterization of cysteine protease 2 homologue from Babesia bigemina.</title>
            <authorList>
                <person name="AbouLaila M."/>
                <person name="Yokoyama N."/>
                <person name="Igarashi I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Argentina</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AB491748">
        <property type="protein sequence ID" value="BAH30175.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769730.1">
        <property type="nucleotide sequence ID" value="XM_012914276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C0A1J0"/>
    <dbReference type="SMR" id="C0A1J0"/>
    <dbReference type="STRING" id="5866.C0A1J0"/>
    <dbReference type="GeneID" id="24566085"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400360"/>
    <dbReference type="OMA" id="CANINID"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="244"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAH30175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="458" mass="51231" checksum="620908F1F06FC94B" modified="2009-05-05" version="1">MSGTRSYMSNDDHHYICSDEVDRDTALIGTARRRRTCTGNKIAICVLSLAAIGAITTGIVLLIVRSTKDPEPPKLMGPRKLVEQRKEMYEEPTQPHGGCLTSSDLLEELNAFYELGGIGTYNDEELCRFVHFKRLEKRYNRRYTDVAARHAGFLNFRRNMAIVEEHKKKANATYTKGPNHFFDMDVKELASKLLHPIDVGQNFQEYGSLGEVIVTKDNQETYSLLKGHTDDPYAVDVGSKVSFENVNWRTPGAVSPVKDQGHCGSCWAFAAIGAVESLFRMEKQQYLTFSEQELVSCDLQSNGCGGGFSDFALEYIKKNGVTSSEDWNYEAINGECSAHHGIRYYIKDYVSARGANVASTLLVRAPTVVYVAFTEDLFHYSGGVYNGECPEEQLNHAVLLVGEGYDATVKKRYWLIKNSWGSDWGEDGFIRLERTDKGYDKCGVLSFGFIPTGAVLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZA1</accession>
    <name>A0A061CZA1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765939.1">
        <property type="nucleotide sequence ID" value="XM_012910485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZA1"/>
    <dbReference type="GeneID" id="24562294"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100820"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="87" mass="9772" checksum="557498CCAC1E701B" modified="2014-09-03" version="1">MRVLLLDVSVYSKGEVHKEGRKHCVNVVPVFSSSSLSHISCPRCHLHVAIPAGTKSYLQASFTLRIMVFFRRKILCTILTACTKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZS1</accession>
    <name>A0A061CZS1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0104250</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766302.1">
        <property type="nucleotide sequence ID" value="XM_012910848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZS1"/>
    <dbReference type="SMR" id="A0A061CZS1"/>
    <dbReference type="STRING" id="5866.A0A061CZS1"/>
    <dbReference type="GeneID" id="24562657"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104250"/>
    <dbReference type="OMA" id="EYQIVNW"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001141">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="449"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR94116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="926" mass="104731" checksum="D539933EC361DE9E" modified="2014-09-03" version="1">MQALEDNRDHFQDVEEEEAAVSEEGEDLYDEETGFVVGQDDIEREAEGFAKLGINVDEYDDSLIDEEEYIDDPRARRAAERRIRYEEQQRQIESRGHQQLWRKILRYDEESAEDGIFERIVQRVESRRKQLQKGDSDAPDFTMLEGAKAVLRADPSVSHFDEKFQQAIDTLFRYFLYRFKLNEKDTRFHYLDRIEKMIQDDANILKVSVPHLMAFHCENMIPWLEFNPIGVMPVLNDCVNVEAHRKRKRLYKGRHCKVALIDWPFTTQLCNLRSRELNTLVKLSGIVVRRGLVLPKLRVLYLKCSLCDGGVDMPIYFSDQQKPLHPQKCAYCGAGSFSVDRINTVYDDYQKVTIQEPPQSVQAGRTPRQRSVILSGDLVDSCRPGDLIQVLAIYKSRYDVALNIKHNFPVLKTELEAVSVEVETNQSIQEDLTSEDIQHIKKLARDPCIRERLIASVAPAIFGQKAAKTAICCALFGGVGKGRGASNSEAEPTQQGDADANSSSSHRIRGDINVLLVGDPGLGKSQFLTYVHKTAPRSVLTTGKGASAVGLTAGLRRDPATGEWSLEGGALVLADLGICCIDEFDKMSNKDRVSIHEAMEQQSISISKAGIVTSLKARCSVVAAANPIFGRYEPSLTFKENVDFSDPILSRFDLIIVMKDVPNTHEDLLLSEYVITNHQLLHPKIENVANYEQVVQNLKNKISSSSACQPLTQKEFSNYLRYAKANCSPVISPEFYRVIEGKLAGFYSSIRQKTAYGGGYPLTLRHIESVIRIAEANAKMRLSNHINADDVDMAIATLLESYISSQRHSVACKLAREYSRYRMIFEGDDHVLVQILRNTIQAQIERNLRRRDAMKLHRSETEMELDDAEVDIAAEATVDIPLFIQIAKGFKFDPDRVTRWLHSSSFNDSFSIVEREGKECIVVKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZW1</accession>
    <name>A0A061CZW1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766139.1">
        <property type="nucleotide sequence ID" value="XM_012910685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZW1"/>
    <dbReference type="GeneID" id="24562494"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102780"/>
    <dbReference type="OrthoDB" id="364806at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="123" mass="14134" checksum="3327C0E9E00E39B1" modified="2014-09-03" version="1">MALWRRICARYSSSSEVLEKGRRALELLKVDAQRLRNNRDVVVYTRNRVCPDCKRKVCVEEPEFAENTCPAAWRHLHGFSQRCPCPLIGVMQFTRFGKLRLELRARLEAKAASAEQKQEGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D073</accession>
    <name>A0A061D073_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothtetical protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0103820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766254.1">
        <property type="nucleotide sequence ID" value="XM_012910800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D073"/>
    <dbReference type="STRING" id="5866.A0A061D073"/>
    <dbReference type="GeneID" id="24562609"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103820"/>
    <dbReference type="OMA" id="EIHYLRF"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="6">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="614" mass="69536" checksum="63CCD0F01FC73469" modified="2014-09-03" version="1">MSDESPTTTGPVRVGQRVILGGNIATVRWRGLAPAKHCWKPSDRRSFHCVVANGEPEDAPPEETEEEQAELLGVEWDNWRVGTHNGTVDGVFYFEPERMRRCEKVMQAVQHVYSGHDEPWLRENAAAYALRTTIDNFENRSCSFVRECDVQLGVPMERAVHNRYITDDPTGESSSPHGKGRIGHEFVGRDEALEFFSHTANLLMLGLQDCRIDRLGDCTRYAFPRVREAHLPNNLISDWDVVRGLLAMLPRVDTLDLSGNMLVFNDEKPLESSTLATVVLNNTMLDFGNVARLLSTVKGLKSLSLCRNMYVELPTLEPLQSLRSLDLTENSVWNWFYVLRLVKSAPTLTRLIITKNRLSNLCVDPETGSPLSLYRAALLIGKDRPEPLKAFAALDELHMEENYVHDWQVVSDLAVVFPRLRVLRLRLCLLHKEATQAEESVHRQVLIAIFPELKVLNGTEVTKYDRINAERYYLSLEHANSTPFKSTNTHEALDEPHSSRLEEIHGKRDVPPPKEGVFVSPGLRMITVKLVPDGDSDSYLKPVVTRSIPLCTTVLELKVICCEVYGLTLSDVVLIYNSGDMPISERMDNDEAEIQYYGVDDGYSIRIQSRRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0L3</accession>
    <name>A0A061D0L3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0105070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766384.1">
        <property type="nucleotide sequence ID" value="XM_012910930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0L3"/>
    <dbReference type="STRING" id="5866.A0A061D0L3"/>
    <dbReference type="GeneID" id="24562739"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105070"/>
    <dbReference type="OMA" id="WTEHVSK"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="457" mass="55147" checksum="FD2352230B0F7F05" modified="2014-09-03" version="1">MATARGYWTEHVSKDGRRYFFNQQTKRSQWEKPDELKTDIERKIESNTNWKPFETAEGKTYYFNTQTRQSVWEKPQEVLQIIREHEQQELSTKENAKTAFLRWLEEFNFTQRTTWDTAARQLEAHERWQKFAMLTKGEKKQLFSEFTSQTQRRIQEEMRRKRGMVGDLIINELDKWEDLTPYTTYVEFAKRCNKREWWTWADEKTRDALFQDCLLRMERDLKWRERERRKLAMDKLENEIEASANENVPEWSNVKLQFSGFEGLHLLEVLECHREVFKRLYRVRVKEAEKRAYRAQRKRRQRFVSFLEDAVSKGEIHGRTTFEEFIQEHSTEAIYLDIVGQRGSTPYDLFKEVQKPLRDQYKNERQKVKSLISKGILDRGATLDEYERIAMENGACSKCNIPLIHESLRRNTNKSHRPRSQTPEEGEIRYSLETASSDESPRSYSRVGYPKRRRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Y9</accession>
    <name>A0A061D0Y9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765973.1">
        <property type="nucleotide sequence ID" value="XM_012910519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Y9"/>
    <dbReference type="GeneID" id="24562328"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101160"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="143" mass="15199" checksum="03E23C009C0B55F4" modified="2014-09-03" version="1">MDSLLVDKPLNLPDFLLEARSILKQPAPVVASPGRLIRFILFTTMVTRNECFFVRGENLLVTLAFNLSTYASFAGNADGLIAKLKSFIDSESVEVAAGNQAEFMGILPLSGPTVGLIVSLSKPFATDADDPVGASIFGSLFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D140</accession>
    <name>A0A061D140_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0106520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766529.1">
        <property type="nucleotide sequence ID" value="XM_012911075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D140"/>
    <dbReference type="GeneID" id="24562884"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106520"/>
    <dbReference type="OMA" id="NDMDNFP"/>
    <dbReference type="OrthoDB" id="427410at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="699"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="830" mass="92518" checksum="F296DFE3750C6AAD" modified="2014-09-03" version="1">MVSDSRRQSSSSMPTDLVDEDGFERVLTPAERRLLRKNASAAAPVRDGNAGVTNFGSLLNKFQSRMKKHGIDFSSLPLTAASALKCESKEEDLREFIRELDDVFKSAPLGVAKPIQFRTLEEIDKRIREATEQFRRLKTNRGKPSGISAEELDSATQENEVYMAHLREQRSIMEGFQSMKTFQAKISQYKQAILDVLSFRAEAERRAASNALNGPNSAATRAARQHEYICGILRRLKEEKGATLDESAVTKSEVMIMATAHRFQPPHNYLRRIKEKFSVHIDPIASSSSELSALHLTVHGEEGDVESCTKFLKSLDFHSSKRVAVESDRLKKAFGGISGLSQLEESFGVLVFYYQGVLDMIGSSDGLNLASNYVEEKIANIDNKESSGTSSARGARSVPATLAEHDARKVELQYDFLICKALSTRFRPAVRTVEADLGVTVSFDVSPKEPKGAIYVNADSTYRSTKVAPEERIKEATAKLREFIATIGSREVPNSSDEETMSFLYSDEIIRSRFVSQDFCILRYNGVVHVVGVNDALKDAVTRVSTLVRYRANKPKELFVPMEKSLLLSSSTLSAVEDWTSVTIMMRDSINGFVLRIFGSPDQQEECIKQVNDILSAHTEYAFDLFPAHMAVLSDNKYRMVRDLEQQSQVRIILNKENNQLVFHGQKDKVDEAVNVMKAFTGNFVCVDQTKVSDISLTGDFYAWLRVPRRHVGAIIGKGGSTLRDIIDNSGLRNMFVNRSDSSDEIVCLEGNKESVQRALEVLGNILEYDGVNQKDQPLTDSFVGKYSSSHSVLRNNSQVVDRRSSSVRSAGGKPIVFDCRDFPVLGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D172</accession>
    <name>A0A061D172_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766033.1">
        <property type="nucleotide sequence ID" value="XM_012910579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D172"/>
    <dbReference type="STRING" id="5866.A0A061D172"/>
    <dbReference type="GeneID" id="24562388"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101760"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="453" mass="51561" checksum="A3DD4C8CDF7E92C5" modified="2014-09-03" version="1">MADSSGGDQPTHRATTISISEGEEGNEGIYGTSESSTRGSDTIEHKGTNENEMSSQSAATRDLLASQAAYEVRQFPLQAAHEVRQLPLEAAHEVRQLPLEAAHEKQRMKSANSGHKERMKSANSGHKERMKSANSGHKERMKSANSGHKERMKSANSGHKERMKSANSRHKQLLQAAHSRHKKLLQAAHSRHKKLLQAAHSRHKRLLHPSHSFHKSRLQAAHFRHKKLLQAAHSRHKKLLQAAHSRHKKLFLAAHSRHKILFLAADTRHKQLLQAADTRHKILFLAAVYRHKQRIKAAHSRHKQCVETAYSRQKQRVVTAYSRQKQRVEGADSRHKILFPAADTRHKQRIKAAHYGHKKLLQAADTRHKILFLAAHYGHKKLLQAAHSRHKQRMKSAHSRHKKLLQATYSRQTKRLEATQSRQKQRVAAPAKMIQKQDIRINVVKLCVNSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D236</accession>
    <name>A0A061D236_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0104910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766368.1">
        <property type="nucleotide sequence ID" value="XM_012910914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D236"/>
    <dbReference type="STRING" id="5866.A0A061D236"/>
    <dbReference type="GeneID" id="24562723"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104910"/>
    <dbReference type="OMA" id="LIPCTYI"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="618" mass="70777" checksum="43B9E4D7ABDFC139" modified="2014-09-03" version="1">MSQFHDTFTRGSRTDPLLSYDDFASRVFTSGFLACFLVPITIYCFYQWTGPKRNSLPQKLKLRENHVEGETTPCFHCGCSMCRQRRTAERNRRFMLEDYMNTATILKVVVLAFFWWLVFYLIKGIDTSQNIKTFDPFAFLGVPIGATKKDIQKAYRHMSLRYHPDRNPNDPEAAAHFILVTKAYKTLTNDKFRQNYERYGNPDGPGMMKIGIGLPRFLVEVGNQVLILSLFFIVLLVVIPGIFFYYYRTQKQYTALGVRVETLQLIYYGITENTRQKTLPEIYASAMECISVPATPEDDVFLRQYAEDIGDIKRKNFTKERLRNFLVLLCHMNRSDDLPPKLKATQAEILKYSMLLTQCMLDVALCRRWLMTTKSIIEFRRCLLQGLTGKRDTFFQIPHLTEDCVGHIQRSKGGGKTISEYVKTPMGLKKGLVGMNEKQLTDVDEFCKAFPQVDLNVDVYVNDANDICVGDIITFEVTITRANVPEECQIVGPVHAPFFPWVKYEEWVVLLTYGEQDDKLLGFSICPSRERVITEKISVFAEKPGLHSVSVTVMSDSYFGCDQSKKVTFTVNTPSETTEFKIHPEDLALDNEPSAIGKMLGDLLGEGDSDEEEEVMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2E4</accession>
    <name>A0A061D2E4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0200930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767122.1">
        <property type="nucleotide sequence ID" value="XM_012911668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2E4"/>
    <dbReference type="STRING" id="5866.A0A061D2E4"/>
    <dbReference type="GeneID" id="24563477"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200930"/>
    <dbReference type="OMA" id="KCYEHKP"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="14380" checksum="32986E1BC6C06085" modified="2014-09-03" version="1">MCSALAPKPVSKRARRDSDSEDSDPEKPPEHAPLLDSGKKRDPIDLRAAIENDAAECERKGLSSWKLSHAGSSSLPARHLCVICGFFGSYKCMECASKRIAELRTYVCGPRCLEVHKDQSCGRPLNLTHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2F7</accession>
    <name>A0A061D2F7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767137.1">
        <property type="nucleotide sequence ID" value="XM_012911683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2F7"/>
    <dbReference type="GeneID" id="24563492"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201080"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="8085" checksum="A454BF86AA6BA60E" modified="2014-09-03" version="1">MALKSVFVIKIAASGPNVSPHSVKLTVTFVVRTSSGVINFHTCLSVPWSMSFLRCLRSRIPRLRLRFFPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Z8</accession>
    <name>A0A061D2Z8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0107700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766658.1">
        <property type="nucleotide sequence ID" value="XM_012911204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Z8"/>
    <dbReference type="STRING" id="5866.A0A061D2Z8"/>
    <dbReference type="GeneID" id="24563013"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107700"/>
    <dbReference type="OMA" id="KIRCCMI"/>
    <dbReference type="OrthoDB" id="364135at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="9">
        <location>
            <begin position="378"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="455" mass="51281" checksum="08B606E6BBF2CB8A" modified="2014-09-03" version="1">MTEGSASPKERHDQVPPPRGIFSIRADALTPGVLYLASGADADGRVSSAFLHVIEKHLSYVNPANQQKGAAEDDDAWEDICRSAIFWRQSNDLQYDEDAYVDASWAAESIEVSREIKELLNTEKPPEDSPDNDIVNANGDHVQSSRVRILDLAAGIGGNSVHFGEDSDLVVGVEMNPQRVEICKNNLRAYGVDHACVVQGDLFDFIEQFAEDPMKKAHELGIQQHFTESQHFDCVHTSPPWGGKNYAGSSNDKVYTLQPNFDVERVMKSVAKFTDIATFYLPRSQCVYELVKLADMGGFPLVIISAYHYRRKTRCIHAHFVKRVECFKYLKVENMERTHVPYKKAPHGLNLLVHSTPYVTSKFSIKSDMHMDRVVHAIMKMLDEKTFIVAAKLHNLLRLHPLSGVMAIANQAREIQNAGGMTKTDSNEKRTTGGIFFHLLKTQDRELYKKMEKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D332</accession>
    <name>A0A061D332_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0108050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766693.1">
        <property type="nucleotide sequence ID" value="XM_012911239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D332"/>
    <dbReference type="STRING" id="5866.A0A061D332"/>
    <dbReference type="GeneID" id="24563048"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108050"/>
    <dbReference type="OMA" id="MIMGWMM"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="209"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="455" mass="50626" checksum="D256AAB56AF6FE45" modified="2014-09-03" version="1">MAELLNDYDVHTRVMAMRERVRRRDPAQREFLQAFDEVVESLMPVFKQNVRYIDVLEHIAEPERIIVFRVPWTNDAGQKVYNRGFRVQFSSVLGPYKGGIRFHPSVNMSVLKFLGFEQIFKNSLTTFNLGGGKGGSDFDPSGKSENEIRAFCQSFMTELQKHIGPNTDVPAGDIGVGGREIGYMFGQYRRLRNTFDGALTGKGYEWGGSNIRPEATGYGAVYFASAVLEDRFGMSISGRRCIVSGSGNVAQYAAEKLIELGAVVLTLSDSSGFLHEPEGFTKEQLQVVMQLKNPARKRLSEYLQFSKTASFHPNEKPWGVPAEIAFPCAMENEIVVEDALRLVDGNVKLVVEGANMPTHNDAVKLLKERGVVVCPGKAANAGGVLVSGLEMSQNSQRVRWTREEVDTQLRNTMQKIYVQCKDACMQYNVENDIVAGANIAGFLRVANAFIEQGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D347</accession>
    <name>A0A061D347_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0203380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767367.1">
        <property type="nucleotide sequence ID" value="XM_012911913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D347"/>
    <dbReference type="GeneID" id="24563722"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203380"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="78" mass="9185" checksum="A4982E687FB69F88" modified="2014-09-03" version="1">MLFDVYRESLLKLYYFLRDEPDAFDKSRSYPAARVDFGINMEPLLKKPEVEIDTPPTTFSATNSWNFYEPNKPTVLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D356</accession>
    <name>A0A061D356_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0108250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766713.1">
        <property type="nucleotide sequence ID" value="XM_012911259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D356"/>
    <dbReference type="STRING" id="5866.A0A061D356"/>
    <dbReference type="GeneID" id="24563068"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108250"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="57" mass="6612" checksum="B2A4DF2F450A0AB0" modified="2014-09-03" version="1">MYLKYYLDADGKRVYTMANAGPNGEVTLTAHPARFSPEDKYSKQRIALKKRFNLLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D372</accession>
    <name>A0A061D372_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0108400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766728.1">
        <property type="nucleotide sequence ID" value="XM_012911274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D372"/>
    <dbReference type="STRING" id="5866.A0A061D372"/>
    <dbReference type="GeneID" id="24563083"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108400"/>
    <dbReference type="OrthoDB" id="364921at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="521"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="576"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="946"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="950"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1273" mass="143010" checksum="8915357A7479F91F" modified="2014-09-03" version="1">MAHCRSSCLVPLSQVPEGTIPKALPTRDGIPSHESYEVVLSYTVDSPFKACPESEPLPSPHADLLRIINSPAYTNENHTTSVHSQDGPTCERLQASGIAVLHTPKKMDATPELRPTMTPQAPPDAEFTNSANRMADSEIQRLTMRGIIGKRAVNVDVSTIERRIMSKVLQDAEARQVIVTFVRDRDDCDEDDHDEVDHEFEMVNASGSRSINLNDSLGYALDRIDGNLFDVPSPKTPINASIPVDTSDIDWFNSTMRFNKIKEYKKHAIPFSGSDNYYHGATSCTMTDSEYNRNKGTLFKDSPKRDEYDDDYDDESDDLMEPPAEITTAGDQTHAVMSPIEPQLNFLKKRKREKTEHREQLSSDGAMTSKSLSRDSTTSSISEGSGQLSHRQRVRRHISHDNCNIMIDEYKNHPDYEEDSDSSPQMLLSDMRAEHSNTSLDRSLSHSRHEGSGSLPRDCSVSNEGISKRGRLVESRRSAESNGGVKALRSKHGTDRVFDNALLNNKDWSSETWGSFINVILSRTCTLGHGSFSTVTFAFLRLTPSLAMNGGRPNSSCSNENIAMALKEYNAAAYRDSNRTTSESEDETFNGQTATDSRSAPTDPKSGNATGNNGEGDIIDQMCSVVSGHCSRCANVRAIDCAVKSINDVFPQARFQYIREKEMMLHFNANVLKPLACRHHNTDGNRSYQLLMPKAQGDLLDMLKRLVKHRTNTCTSQVYIASQSTGKQERKIIGLNETEVKFLFYQVLSGLAFIQMCFQGNIHRHSDIKLQNILVLCRDEDQLNPMRWRLCLADFGCSIMLHPTQHLEGAGLFRTLHDSLSKEWRTHVCNQLTSFVRGTVRSNAPEALSYDRHGKPRSNHNDRLLTAYKRRRLRMSYMNKDQLPMPRVWVQGNVSEEMKRLPPRSAIRVPGVRETDTAEYYTVDMHADMWSAGIVLAELAKFGGPNPCSDDSRSPNDSSKSKGDTLPADYVNQRLNGTLGRGIFCRNNAVVKLKMQLEAAREKGGPKASLKVAANDKAQQNSNQAALTDENLNMALATDIAAKCDQETVMRVRKLKREYCWWEYPKFSSGFWSLLANLLSYDPAERYIAAEAMGHAWFESSDGDSRPIFDDIDALMAEQHQHLPMEHFFYIGSSLSLHSGYRKGPCNNESSPFTVKREALMHVENSDVALESVGDYGKAGRTSHAWFAGPLHFRLRELHEPGVDLPDYVAQICQRETIVLESREKELFGTHGFVLAQLLALRRRYMFSWSEMMSARAVHLLGKSLMLRDYAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3E9</accession>
    <name>A0A061D3E9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766793.1">
        <property type="nucleotide sequence ID" value="XM_012911339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3E9"/>
    <dbReference type="GeneID" id="24563148"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109050"/>
    <dbReference type="OMA" id="LDIMIHA"/>
    <dbReference type="OrthoDB" id="366014at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="242" mass="27269" checksum="CAD218DB78176EE2" modified="2014-09-03" version="1">MSTRAAVNILSMDVVQLSHYVRKRFQPSLVATEDSDENRDLAYQILALKDQLQNNRRERIKIFYNLVQAAHHGFFGHKATRNIYIGFPYLHRHFSENYRTFAAGKPDPNSGLGDQLLFDAGKLLSQHTFSAAAAHLRAFSNDHALIIVDEDVRLSKLYVKTLLELLGKNALTDEIKDEIKNALSQAVKQWSIELTGEENVDNLIELFALTSSLGLEDPGLMPVIENLIRGKRTPLSNKGNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3W0</accession>
    <name>A0A061D3W0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767587.1">
        <property type="nucleotide sequence ID" value="XM_012912133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3W0"/>
    <dbReference type="GeneID" id="24563942"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205590"/>
    <dbReference type="OMA" id="DNSDICA"/>
    <dbReference type="OrthoDB" id="363630at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="162" mass="17799" checksum="FC12D439031975CE" modified="2014-09-03" version="1">MVSTLRPLKTQQLLSIFKVLDRQKRGRLGLQELDSIFSDMLGTNLSSDELRCVMKHLISLGAAAEYANVAGQETITDPQELDFSTFIDAVNSTIKLQPLEYILRGTFTKLTGGRELITVEDLLQLANKAGIASGSDARVRLVTRMPNESADFAEFCKCVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D401</accession>
    <name>A0A061D401_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BBBOND_0100330</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765890.1">
        <property type="nucleotide sequence ID" value="XM_012910436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D401"/>
    <dbReference type="STRING" id="5866.A0A061D401"/>
    <dbReference type="GeneID" id="24562245"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100330"/>
    <dbReference type="OMA" id="IAITTWH"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1097"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1123"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="65"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="931"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="279"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="682"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="713"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="793"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="884"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="904"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="907"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="908"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="908"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDR93704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1166" mass="131493" checksum="02A461C8ABE87997" modified="2014-09-03" version="1">MANVEEPTAGERGAADATDERWVLEELSKPVTFMDRVRFLIATRFNNRLMPGLRYVSIRGGSIPRSFVWNGIKNTKYNVLTFLPYVLFEQFKVFMNLFYLLISLSQLIPDLAVESAITYFGPLALVLFVALLKEGCDDYKRYLRDREANSQKYEILTNEGIKEINAENITVGSIVKLSKNQRVPADMILLRSSEANGSSFIRTDQLDGETDWKLKKAVHVTQRLQSAEDIVKLNAVCCCEPPRQEIYSFYGKITFYRDGELLTKNAIPSLSRDLRSEAIRQSMSSSKDEHTTADDPRSLYNSFSIPSQGNMGETQAADGDSDMDVVVEPLTVDNALWMNTIVAAGTLYGLVIYIGKDVRASLNARRARYKIGCFDWEVNLMTKVLFFILLCMSVAMVIPGGFVGRWYISLIKFLLLFSTIIPISLRINLDIAKFTYSRAMALDNEIPGTVPRTTLIPEELGRIEYLLSDKTGTLTQNVMNLDRIHIGRALFQLDDLDTIRQLVDKHFMEYVSSQPEVSEALTYSEEASKSRSSMRASRVGSTLESAASGHATTNQAATAKAARKSAIYIPHTKVSQTSEMQTKLSLAILSLAICHSVTPIADKDDKLDFQASSPDEIAMVTFARMCNVELRERDETRMVLRVRGCILLTYKILMVFPFSSETKRMGIIVEDEETKMKFFFCKGAESALIKLLQPRGSVWLSEECDNMARLGLRTLVFGYRHLSDAEFSAFESRYRHAQLSLNDREEMIKRVIATIERDLILVALSGVQDNLQPHVRSTLEALRDAGIKIWMLTGDKVDTAKCIAISAGIKDKSHSLCQITSENTKDKDDIKQKLENFSMGPTSTMLVVDGTVVATSIKEFSKFFIMVATMAPAVLCCRCTPFIKAELVRLIKQYTGKRTCAIGDGDNDVPMITEADVGIGIVGKEGLQASLSADYSIHRFHYIKRIILWHGRNSYKSSASLTHFIIHRGMIIAVMQALFSAMYFYMPLAFFQGWLQIGFSTYYTMLPLYSLVLDYEIEESVVFLFPELYQTLHTGRVMSVKTFLIWVWISVFQGAILMLGAIILFENSMLSLVSVACTSLFALELLNIYAELHTCHPLTMVSMICTAVVYFYSILILRNYFDFAFIATTAFVWRVIVITLTGWLPIYVFKCVQQLLQPPQSRKLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D412</accession>
    <name>A0A061D412_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0206340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767662.1">
        <property type="nucleotide sequence ID" value="XM_012912208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D412"/>
    <dbReference type="STRING" id="5866.A0A061D412"/>
    <dbReference type="GeneID" id="24564017"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206340"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="687" mass="76589" checksum="20667C240FC7F7B3" modified="2014-09-03" version="1">MGYLTVGAPLSHEETAKLANRIRLLGTLEVLRCYLNNHDRKDATRWFGHECEYMLIHLDPAARSARLVPCAPLLLEKIPVPLEHDAGQFIFMPEFGAFMVEGTPGTPWILDKDNTTEVFEWFSGARRHIRLGLERLGITDVHPFTLTSFPLLGTPDSVFEHPMIKPPQQPVMLSEFCGDVLVNPHPRFVTLARNIRLRRGKKVHIKSPPFVQNACIIPPGASARVAPATGAPPTKAPAADPHSPLAPRAVEGTAAATDEKLVLGSRTGVNLSFDFRKEAEAALSSAFLDPANHIGDADLRREIDSVIASSDVRNQDKIPVVAAANHDPIYMDAMAFGMGMCCLQETFSCIDELEARYLYDQLAVLSPLFLALTAATAVFKGTMSSHTTRWRVLSQSVDDRRDDELERVPFSRFSTASLFVSLDPYLLAHYKRLNDVLVPSRPDVYDACVSAGMDRVIARHFSAILSRDPLVAFEQDLDAVDIHSTDEHFESFQSTNWNTVRLKPPPLKGSGYPIPWRVEFRCCEAQLRDKESAGLACAIALLVRVMLKERWNLYMPMSLVHENMEASDSQDAITNHKFHFVTDLSRGSGEVGRYTLREIFFDEDKLGLFARCATHLAHELSSGALSQQSYDLQIDYLNVLKHRAYGASATNSQEIRDYVLGHHEYRGDGVVTPHVVHDMLDAILKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D479</accession>
    <name>A0A061D479_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Core histone H2A/H2B/H3/H4 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0101030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765960.1">
        <property type="nucleotide sequence ID" value="XM_012910506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D479"/>
    <dbReference type="STRING" id="5866.A0A061D479"/>
    <dbReference type="GeneID" id="24562315"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101030"/>
    <dbReference type="OrthoDB" id="420022at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="315"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="415" mass="45395" checksum="E54FB15FC1E519A2" modified="2014-09-03" version="1">MASDSDVEGYSTPEEDATFDDVRPSRIPGVGSASRHFFGDDLVVVSSSSPSDSSVQEIEMESVGDEVYVVSPRPQSVTRSARSSSAVSLDLAPSRQTSIGSAIGAAALARENRVLDSDTTLGTSMVDGGRDSFASATSFPRDAESRGSVTGRSDRQPRVSVVGRPIDVGASSVRGSLHNARNTDGGSTSSASRRFATESRPSTSVAAPSQPDMSDAVTASLLAEARAAPVPKRPPIKPVAVLSPARIIAEFKRGSMSKQQAVESLIRYRMNKMLHKNSDRMYVDKDGDVRFVKGYDFGKSRDTRGRVIRRNGLTRIEREILAYQKSTHLLIPRAVFARIVRDIAQTWWRGPEPVKFTVEALSALQAATEDEITRLLEISTACSYHAKRITLRIDDMRLARFCRGRQEYEFFNIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4J6</accession>
    <name>A0A061D4J6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767684.1">
        <property type="nucleotide sequence ID" value="XM_012912230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4J6"/>
    <dbReference type="GeneID" id="24564039"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206560"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="73" mass="8284" checksum="3F502F44F7452222" modified="2014-09-03" version="1">MDEGKAECDSQSGMKCQKHDESLRYVVGMRWLGNTFGNPQLNKESGPITLEIHRVALDYVALREPHKHMANQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4N9</accession>
    <name>A0A061D4N9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL/TRIO domain conataining protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767724.1">
        <property type="nucleotide sequence ID" value="XM_012912270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4N9"/>
    <dbReference type="GeneID" id="24564079"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206960"/>
    <dbReference type="OMA" id="CENVTVF"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_125, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="154"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="323" mass="36712" checksum="5F085C99BF43A783" modified="2014-09-03" version="1">MGVMNSDSDSCNALGYDDPLLDSIVLPEYVKNFVPTGDQLNTVRTDYAAFHRFQVTRSGHQIRFIFSNVQFTNFEQEHIHAFKVFAIQKLEGPQLDTNQAVVSFKKRFGSTIFADDGYLLRCLIGNNYKYQAALDDMKENLQWRKATLPIHRSEIEGVLARGIIYIHGRDNCMRPIVVIQLRNVAKVQPEHVLRCIFFTLELAINKLMIPGRIEQWKVIIDMSGTNLLGLQVSLIKQICRALTVNYRGRLSQMFLINAPYIISGLWGLVKNVLPEVTQEKIQISSGKNTKKMLETVDPSQLEKKFGGNAANVTVYDLPVMPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4U4</accession>
    <name>A0A061D4U4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase with zinc finger motif protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767253.1">
        <property type="nucleotide sequence ID" value="XM_012911799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4U4"/>
    <dbReference type="STRING" id="5866.A0A061D4U4"/>
    <dbReference type="GeneID" id="24563608"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202240"/>
    <dbReference type="OMA" id="DHVNIIM"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000190">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="255"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="510"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1153" mass="131348" checksum="BDF13681BE8D18D1" modified="2014-09-03" version="1">MTSLYDNISDFWTSDEEQKDEPRPNELSLGTVRQDASAFKREYHPLDFSQAFTNPLDSMSWVPIMDQAELKDSPFDLLDKDDHDSCFDIDVDLLEKQLFGDSMDFADNEPEFNLADMATELDAMTRGGVDQLTEPHLGQTGASNVEIAAEQPQANKWLDLSNGNSTALLYYLMHQLKRRAEPWPASQHRTSIIKIKPVNESEEPVEAAMVVPKPDDEKSYIRTKWSIVDDSSLPETENYIIEYPFELDDFQKRAIHHLHRMKHVFVAAHTSSGKTVVAEYAVALAISRGKKAVYTSPIKALSNQKYREFTKRFGSEAVGIITGDVSCNPNAACLIVTTEILRNLLYRGDAIIGQIGVVIFDEVHYINDVNRGVVWEEVFIMLPKSLQLVMLSATVPNYTEFADWIGAIMEREVITIVTSKRPVPLMHFLYIYGRVFLLLDNKGFNKDAYHQMYKYSTLTKSGNVKRTTFKGHVQKLQRLIRLLETAHKLPVVLFCFNRAKCEAYAREMPNLNLSYTQVQRSRIHLFLKESLSSISESDRNLAQVRSIIKLLYRGIGVHHSGLLPLMKEIVEILFSRGLIKVLFATETFAMGVNMPARSVIFTSIHKHDGQKTRHLTASEYTQMAGRAGRRGLDSFGSVYIFCPDDPPDLQDLTNMMFEKSTKLESRFRITYNMLLQVHSREHMNITEMMLKSFKENDKMKNIPIFKRDGVRKRQELLTLPKVDCIYGEPSIEEYHRLDMLSRRIANSLHENLWNHRENAQIFKAGRVLMVHSLGFCNTSSYACIIASSKGKALELKVLLLLPDLYDESKATGTIHTTISAYNHAEIRFAICESIDVRNVSFVYNNVVNVKNTNASFGDTKEIGVALMASVASELHKLVDTKKLELLVFNKQLKQTSLQFYGVVLKQRDIYHEMSKNKCTNCHLKDKHYSVQARVKECQREIEEISANLKEESLHAYDEMISKVEVLKQLEFLDEHGKPTVKGRIATYLTTGDEITLTETIVQNVLSGLEPEECAAILSAFIHNDRAPEKEVPAPTQAIQRARDAVLDLHNKIDVVQRALNVNVSREEHASLCNFSLSYVIYQWATGTPFNEIMQFTDLQEGHIVRAITRLDELCRKIGQVAHINGDEELQNKIEKVSNSIKRGIVFMPSLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Z0</accession>
    <name>A0A061D4Z0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein LTV1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767942.1">
        <property type="nucleotide sequence ID" value="XM_012912488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Z0"/>
    <dbReference type="STRING" id="5866.A0A061D4Z0"/>
    <dbReference type="GeneID" id="24564297"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209100"/>
    <dbReference type="OMA" id="ERRWDCE"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="495" mass="54393" checksum="08C2393D4DC16105" modified="2014-09-03" version="1">MEGGRAASGKPRKRVTFKLVSASSADPRVASNPWQRTLVLKNSSNAALKVRSAGAAANDVQKGDKTAIPKEFLSFINPADFGIHENLTGPQKDALIAEVYGSHEEYERIAAKFADAPAPAKPKAEDLDDDCYFPKDGYDYSQHLATINPQNFIPAPRVEAAASIVKAELNSSVDFPGLNDTAPETPDDPELAEVLKALDESGSEAEDMDDDFVAKAMDNEDPDTFIDENELLWGGYKPLRRVTFEDLGIPKGDSAPAPVFGDQPILSDEEFVISDEDDDEDSDFDAEYDPTESLAQSAQAQLDALRAANMRTSMLDMVNCGPWGARAEEKETMDAMDPDGALSERILQLVQQPDDSESGDTVEFELSSDESEQWDVETVLTKYTNATNHPQRILSSVVRRARTRERPEGAEEPSAKAVPDVEYIELPQVVTTRRRDETAEEKRARKAAVKQAKAMITRMKKENKEALKSAKKKAAEKSAVGSYDIVNGVKYLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D586</accession>
    <name>A0A061D586_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0209940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768027.1">
        <property type="nucleotide sequence ID" value="XM_012912573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D586"/>
    <dbReference type="GeneID" id="24564382"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209940"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="89" mass="9918" checksum="F86F3D8A79ACDE5C" modified="2014-09-03" version="1">MENATLITRQMLPSLICIVAFAKISTAHIDTKHPANLFNENAPLYVNGPQVNFEELEQLTMPHSEQTNVEAPDLVAKITLLIDTQLHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5F0</accession>
    <name>A0A061D5F0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767969.1">
        <property type="nucleotide sequence ID" value="XM_012912515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5F0"/>
    <dbReference type="GeneID" id="24564324"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209360"/>
    <dbReference type="OMA" id="MEEARCA"/>
    <dbReference type="OrthoDB" id="392568at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1005" mass="111865" checksum="7349BAAFD7E987CC" modified="2014-09-03" version="1">MWSLHFSRRLFGSAALRCEPARTSSSSLRPSAIESKRTNAPLKSCATSQPSSTSSLDTRIRGAKSLQKLFSLCASTAQPPASALSDPRLSAVGRLYALRIIDSSGVLRQPLGDATLACVEFAESATWHLLDQIERYAVTGAVSVPRSKHLVGLLWHSMKIASSLAGSLRGSDPIHVENKGVTAIKSLTHSPPSDALSSRMLSRWSLVRRCLAVVQLVVDGIVAGLARPNGKDVQQLLMLAAEPIFTHIQTNMPHKDEERVEPDEIHQAMEEARCAALRSIEVLAEQCAHLMTDSELVSVFVSCCSKDVSPRLISFLNQSMRDRAARGFINLALQDCVTLFNISKTYKVPSEVMSILLSQLATVPLCDDETSSSPKANRLQHEHSNRPLLVGCDSDALEVWHSSVRKATFADVGRLCRSLYHQECGVELLRNIDSALTNTLGSAAFVSRLSAESRQDTGGVNTDLFSLSSIIHLFAKNNFWESQAVEKVLQVLPQVPLGNSSKDELVVLGDLCWGMLTLRVDVRRIGFLLDHVIPQLKELPIKNTVKLMGGLYNSLGRDAKRTPDEPDTVFSLDRVPMDDLLAYTLNDEDFSATGGSDIHSPSVSSESSGDGRRDKVIRRMKVLRSLFMDRLEEVTDSQNLSNFMFYAAATIKDINEGDYNALCLKWLANSRNPDFMVKVEALSQLLWALQKNRIYHHATLMRIREIVSCLASDNKVVQLCAKFEVCSMGQLALMSHTLMSFNLVTQDLTDALLTRLEALLDGHRADYPSARGRSEVGDWDVKLTSVIWSIVLSDFTLLNFASLDRLIRLIGRINWRRFVKACRHQDLRKVLQIYTSLEVELPKLSAYMPLWPLHNLIPHQVISAAIRDTISARNSVPVSASQDRVRRSLSSFGVRFKGEYAIYRGITVDFAICRNQDSDEFSPDLVIEMDGPCHYNVICGEYSLPHLKIGAMRLLPTGKTLYRNRIIRKLGYTVESISWIDAHRRAIHVAVGNILNRHEITITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5F7</accession>
    <name>A0A061D5F7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0204250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767453.1">
        <property type="nucleotide sequence ID" value="XM_012911999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5F7"/>
    <dbReference type="GeneID" id="24563808"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204250"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="73" mass="7932" checksum="CEB2681D20982ECC" modified="2014-09-03" version="1">MTASSSCGSLSTLCGFRKRKNNGERMVFGNRVDVLEAIEAGILGRKDAKSPVQMMAPTKEGVEVDGRSDKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5U6</accession>
    <name>A0A061D5U6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0212330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768277.1">
        <property type="nucleotide sequence ID" value="XM_012912823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5U6"/>
    <dbReference type="GeneID" id="24564632"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212330"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7095" checksum="DE3D2F1A5813940E" modified="2014-09-03" version="1">MKIAANPVRSTPTVQQHRATSRGIGAMLAERVGYVPKCDINNRYIDAYIYYLTRLTPITPPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5X0</accession>
    <name>A0A061D5X0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0205700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767598.1">
        <property type="nucleotide sequence ID" value="XM_012912144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5X0"/>
    <dbReference type="STRING" id="5866.A0A061D5X0"/>
    <dbReference type="GeneID" id="24563953"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205700"/>
    <dbReference type="OMA" id="ITWDCER"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="269"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="385" mass="41577" checksum="3EF17DFC287AC94B" modified="2014-09-03" version="1">MWVKNLDDFAEKDAEEDDVFHLKPGCVIDDDSDSDQPLDTTYECWRKEFKAELISLSVHPAFPEVAHVAVGSCDDTCTIVDLSSQDEGSEAQQTLLGPFEETVSCCAYSPNGAYLSLGCMDGCFLVYSTVGTKYDHMCTVNGPTDGIEWISWLGDSSAVMFGGSGHTVYIWDPQLQTTACVNTTDTNSCGKLCMYGDNALAVLGGDDGHLNIVRYSNGTVGSVSDVPLGKDSVTCVDCHDTVQLAVAGLYDGSLYFVGLTKKSISASFLEDHTDTVEAVKFCTGASSTMAVSCGHDGRVITWDCERMAKLNVVPLLSKLTRMVWVPSVLVVAVSNVRGELYTLKNGKVIKHNRPHQKMVLDLATLPCDDDECALLSVSEDGSMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Z8</accession>
    <name>A0A061D5Z8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767628.1">
        <property type="nucleotide sequence ID" value="XM_012912174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Z8"/>
    <dbReference type="GeneID" id="24563983"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206000"/>
    <dbReference type="OMA" id="LKYMANG"/>
    <dbReference type="OrthoDB" id="361478at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600082" evidence="2">
        <location>
            <begin position="24"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="274" mass="31017" checksum="88DC46DA2D429926" modified="2014-09-03" version="1">MKLFAAPLAGFVLIAHCVVPAMARINVTHSSTMAPSFLARESDIERVDKMAGVVLAEMSNLHDDVIDAVAQKMLSFLETQGLDYENPEHINTIISLLENVDNTQPEQNKGSKFLDQLKQMAIKAWHTTKNVAKSTMKELLLRCIKEFLKVGVRHALPPLAKINEKAMLALPLNIRVALSPIAYNMWLNLFRRAKLALPEDFKIESFVCKNIGKDKCDEVIKQVKDSLAQMNQKPVKEMEDIEVEDDSDMFDFDDEEKRSKPAKRKSTAETEFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D685</accession>
    <name>A0A061D685_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0107370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766625.1">
        <property type="nucleotide sequence ID" value="XM_012911171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D685"/>
    <dbReference type="STRING" id="5866.A0A061D685"/>
    <dbReference type="GeneID" id="24562980"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107370"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="330" mass="35549" checksum="DF3775108BF6DC4D" modified="2014-09-03" version="1">MADIAAAVEEFSKLDEFSKPDAELLSKILLSPDVKLSLQLRALYFCRDLKSSECATLLKKALDVHYDAFLRHEIAYVIGQAGCEEASDVLVKLLEDENEDPMAAEAIAAIGGKRFIDVIKKYEDDPCVVVHDTCRLALHSLLNGSSEEDDGKEAIPICSCVSAPISTSAYRAVDPVPCTSTEMNERTMKELEVVLLDEALPLYQRYEALFNIRNIGGDAAAAVIGGALVGDKISEVFRHECAFVLGQMQSMAASDALLECLKNADEEPIARHEAALALGSCASVCSGGRNRQLILDALNEYTADPVKVVADSCVVALDVVHEADRLAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D696</accession>
    <name>A0A061D696_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767723.1">
        <property type="nucleotide sequence ID" value="XM_012912269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D696"/>
    <dbReference type="STRING" id="5866.A0A061D696"/>
    <dbReference type="GeneID" id="24564078"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206950"/>
    <dbReference type="OrthoDB" id="365051at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="330" mass="37531" checksum="B160FF2E6E35FB20" modified="2014-09-03" version="1">MATYSEIVHELYNLSAQGVRADDVRFRQLLSALDSAREKRKPVESEYYGMKGSVRNPVSSSQFERTLNQIDAVYKYLAVGSDVPPDLLLRCGVDCSTVNEKQAEKQSDAADILHYSEALHVGGSHWTPSLGWVEYNESLAETRTSYTLNAVSNLRSLLEFVMEKGSAEGMESVEALIRTLGMERFADRFRSHGMIRVNKFLAGLMRLERQLRLLSLQRTLKRALRMVHHFNVTEPSDPNLWHAATEMHGWGEHLAEFVTRSRECDHMRATLACQAAQMVASRASMKMMPTAVHSQFDAMPPQYYQPAPYAQVWQPVPHPHMGMFPPQHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6C0</accession>
    <name>A0A061D6C0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCNT-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768422.1">
        <property type="nucleotide sequence ID" value="XM_012912968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6C0"/>
    <dbReference type="STRING" id="5866.A0A061D6C0"/>
    <dbReference type="GeneID" id="24564777"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301400"/>
    <dbReference type="OMA" id="AYYKMAN"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48295">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48295:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="2">
        <location>
            <begin position="194"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="265" mass="31026" checksum="053494281EE0832E" modified="2014-09-03" version="1">MASILTMNLPSDDEADSDYSLSEPSSGDEREVKKTKRQLKRELLLEKQRQDLKNKVDALFGDMMQESDKAYRHKQTVKATDFMLQFHKKDYSSLGPQNRRIGELENFVTLSSSSVFEEQQTLDICEFKEQCRNTPDSEKLELIHRAVKDADKVEPSTIAKTYKFAGKTYTVKEHVDKSSKKYKQFAKKQRMAVGGSLSFIDDMVHELDSAPKISAIRKSEADWNQYKDENKIDTLHKDHRFLKEQDFLHRAQWKEHDNYLHVRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6E9</accession>
    <name>A0A061D6E9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767778.1">
        <property type="nucleotide sequence ID" value="XM_012912324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6E9"/>
    <dbReference type="GeneID" id="24564133"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207470"/>
    <dbReference type="OMA" id="TADWVYR"/>
    <dbReference type="OrthoDB" id="363718at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="326" mass="37582" checksum="6871FDA512FFB7EC" modified="2014-09-03" version="1">MINRISTSNSPVGTSCTLICRHFAAFRRRKVNALPLSSQAGKPQGDDAYDPPIPPSFIPCDATSYQRGWKPVQGDPVPGYEVPTRFRIGMRQHTSADKKNAVTYSRDTEFGQTYTDFSGLRFPTLDTAENTNYWKDTGLNRLLPRIFPIKLPMKRKIDPLMREYMFFLHNLDPGRFTIPRIAERYGFKESTVREVVREFSLLNFILYNKLCDPRDKRITLEEARLQLKEQAYRDNIGKLLRQIHNTQPGYVHVSDEADEEENEFQGFGSTADWVYRQSVQVEGLSAFPLPSTRDPMPKRVDVDLTVKHTKNVKVINWIDPSDKVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6P1</accession>
    <name>A0A061D6P1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766800.1">
        <property type="nucleotide sequence ID" value="XM_012911346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6P1"/>
    <dbReference type="GeneID" id="24563155"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109120"/>
    <dbReference type="OrthoDB" id="10417175at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="378" mass="41646" checksum="5BBBCC3517069C49" modified="2014-09-03" version="1">MVYNSLTDAPRNLKEAIDWLLALKGTEAENNFNAMASAVYDFLADKPVGRIKVRALEKVKSISHKFMGQKALKEHSFVKIMLRRFESEMSTKFSLFHRHFGSLAQSDCENVIEATGVKPEDIAVELAKAVDGCEKFLDDVKIPGQYSSAYSSRATWDSSCSRKPEACAVVLVGIAPMLYAGLRSLKEASADVVNRQWLVSYAEMHLKDVLKAVGYKTQEYRASMSGADISTALNSVKYDMLSSIYDLAGFWAFYGFDKIGDLKVEQPKDPKADPSVEGEGKQPVIPEAEPSVYGEGEQSVIPEAEPSFEGEGEQSVIPEAEPSVEPVQPEVDDVEQPVKVAKAAKVARSVKAAKKAAKKVSRKARQKKEKKQQESAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Q8</accession>
    <name>A0A061D6Q8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0302800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768562.1">
        <property type="nucleotide sequence ID" value="XM_012913108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Q8"/>
    <dbReference type="STRING" id="5866.A0A061D6Q8"/>
    <dbReference type="GeneID" id="24564917"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302800"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="264" mass="29895" checksum="C83FD789E9D6DCBA" modified="2014-09-03" version="1">MAVGKNKRVSKGKKGGKKKVVDPFLKKEWYTLKAPVMFHVRNFGQTLVTKTQGTKLAIDGLKGRIFDVSLADLNADEDQAYRKIKLCCEDVQGRNCLTNFHGSSVTRDKLCSLIRKNYSLIEAFTDVKTTDGYTLRMFCIGYTKRRPGQLKSTCYIRTSKTRVIRRKMVQVMQREASTTSLREVVKKIIPESIGKEIEKACKGVFPLQNVLIRKIKVLKKPKFDLTKLMEVHTDISEDTGHGMKVQESEDAENLLTKELNASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6S0</accession>
    <name>A0A061D6S0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0208610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767893.1">
        <property type="nucleotide sequence ID" value="XM_012912439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6S0"/>
    <dbReference type="STRING" id="5866.A0A061D6S0"/>
    <dbReference type="GeneID" id="24564248"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208610"/>
    <dbReference type="OMA" id="PNNTHMD"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="678" mass="76026" checksum="FCF8B34C1267F795" modified="2014-09-03" version="1">MALARHIRLVVKPLVEIPGVDDVESALKKCNATGLVEIDEDNAVCRSTADCSRNGGRAVSDSSVGNTAVDSVRQECRSVARRDAAPAKLHRETLVWTSHDGITQVRFCSDQSEFELTGTDVKPLDEYTIVAFYGSVERGCEDVLKERFVSHESATEALMRLTGSFSIVYVSFRTNTVYVFKDEIGIRSLLWGRHDGVITVTDVAFGKQTEWYEIPPEFMITIHDEIKVVNRGLTMLQKLCHQSKIAYSVLTIDDVNHAIQLVYDGIASAVVELCDSRSIRDRVTILFSGGLDSSLLASMVAQHVKDLECIELVNVAFKPKVAPDRITAICTYEDLTRIYPEVNFKLILVDVETEEYKKVEQELMARIMPNNTHMDLNIAAALHYAVALKGTVMQPQFIHTEEWQEIKQNVALMKSINLRVTISKGSDTQTNNEELDGGKDGTCENEHSTDNTRKHDRHAKTASDESDVVDVLWEQLIQLRGSVNAADEDYTSPSKHVIIGSGADELFGGYGRHAVAPPTADVSFSKEVNKDIRRLWKRNLGRDDRVVNAQGVTALYPFLHPSVIRVLTHLKLNAATVVDALECPEWVKSLGVYQSLQYSTFKNCEFLHDRRNREVAIYINKWILREIAVRIGLKHCVHFKKRAIQFGTRSAKTFNRLRGMSNRVASDKGATIIMNNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6T3</accession>
    <name>A0A061D6T3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767903.1">
        <property type="nucleotide sequence ID" value="XM_012912449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6T3"/>
    <dbReference type="GeneID" id="24564258"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208710"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="9007" checksum="6BEDAD3130AC5E8F" modified="2014-09-03" version="1">MLGIYFTIKHCNMFQNGIRSMIQCLMYFLAVHTKKGIRLGCGIERENKRRKRETDVYVVIDNSCEHLIKMSNRYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Z5</accession>
    <name>A0A061D6Z5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="7">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0209200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="7"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767953.1">
        <property type="nucleotide sequence ID" value="XM_012912499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Z5"/>
    <dbReference type="STRING" id="5866.A0A061D6Z5"/>
    <dbReference type="GeneID" id="24564308"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209200"/>
    <dbReference type="OMA" id="NRDCSVK"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="174"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="600" mass="68093" checksum="DA05310F4DFB2415" modified="2014-09-03" version="1">MAPLCGQNMAAAEPRSELKQHRLREVSRADSRNLYYIGMKSNMAGYQDSADVAGEKVKKPQGSLIARRLSSADTEVSSTLFRRMSSVGKQYVPHSADGTHGGVALPPTNMTKGISVSARDPPRNHFGENNFKSSCPVTEHRRQHPAPVPTRTKGASAKQNLVAGNTVWELPEKYKVIDIVGSGSYGQVCRAFDIENQRYVAIKRIHKVFEDLIDCKRILREIAILNRLDHPNVVKVLDIVIPSDLENFNVLYVVLEIAASDIKLLVRSPAFLNDNHIRLLIYNLLCGVNYLHAVGIYHRDLKPANCLVNRDCSVKICDFGLARTVTHRRDSAPLSAHGSYTAREVEDEVFRGDSSVRTMPDSTRLLDYNEELAHFQRKKMNETFARQLTGHVVTRWYRAPELILLQENYTSAIDVWSIGCIFAELLNMVKMNVPDASARSPLFPGSSCFPLSPDNKNSTDRAKDNDQLNIIFNVIGTPSEEDIAAIAKPDVRRYVRMFHKRNGVDLYKRFRATPPLAVDLLQRMLVFNPEKRIKVSEALQHEYFRDLYNPRHAEVPSQPVVVPFNDWINMSEGQLRYAFLREIQRHHPEFKIPLKIIYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D738</accession>
    <name>A0A061D738_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0302370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768519.1">
        <property type="nucleotide sequence ID" value="XM_012913065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D738"/>
    <dbReference type="STRING" id="5866.A0A061D738"/>
    <dbReference type="GeneID" id="24564874"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302370"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="259" mass="30366" checksum="5B8244CBACB1B3D5" modified="2014-09-03" version="1">MALERFLIKSFRGIPKEKCNEGLQKKVERNEQLKQIQQRKITKHVERKRKRLEGLRNRALYHAKEYIKHERELVELRRKAKAEGSFYKEADAKVVFVVRIKGINKITPKPRLILKLFRLLQLHNGVFIKLNKATIEMLKLINPYVTYGYPSLATIRKLLYKRGYAKVGRRGAWSRVRISTDDIIEENLGKYGIHGMEDVVHQIYTCGPKFKEVTNFLWPFKLSSPRKGFVAKRHGFTEARGGDAGNREHLINDLLKRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K4</accession>
    <name>A0A061D7K4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767055.1">
        <property type="nucleotide sequence ID" value="XM_012911601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7K4"/>
    <dbReference type="GeneID" id="24563410"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200260"/>
    <dbReference type="OMA" id="FGDVMNK"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="82" mass="8925" checksum="A35B7ED69D9884BD" modified="2014-09-03" version="1">MSKDSTAAPAEVNAALNLLVLTMLNEQVKKVCFGKCFGNKFGDVMNKNEQICLAKCMDRMYEAHTILSQAAAEAANNIAKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Q7</accession>
    <name>A0A061D7Q7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765936.1">
        <property type="nucleotide sequence ID" value="XM_012910482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Q7"/>
    <dbReference type="STRING" id="5866.A0A061D7Q7"/>
    <dbReference type="GeneID" id="24562291"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100790"/>
    <dbReference type="OMA" id="NMIYSSW"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39227" checksum="86B99892CC6DF4F9" modified="2014-09-03" version="1">MFGGFNDQDAFGANWNLDEIQQLEDITAGGFIEDDALPPHDNLALNADKVAPTKQAMMPAKIGMIVSAWKGETSYIQFFNKIPDIVKILGRIEKYKSTEENTMIVLDDGTGRVPCIYVHPSDMTSFRQRELDRVLQSQKMVVVYGTYNPIYSVKCPALIIFKIREVCAPDEFALHELDVMHMILRNERDGTPLQTVDVGYVLQDYAPKPVELMGDPVDSGMPTMPTSAAINMHNNGAPGSDSSVNSAFSPGVTSNSSPAMPSTMTPGGGSVSTPGTAGANTPDCQGPLTLMKYIAHLLAAETRNGNLNGLHVGEITRLCKQQRNFQSISEQHVRKVLAELEKDATVYQTVDAHTFASTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U8</accession>
    <name>A0A061D7U8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 8">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0212090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 8"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768253.1">
        <property type="nucleotide sequence ID" value="XM_012912799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7U8"/>
    <dbReference type="STRING" id="5866.A0A061D7U8"/>
    <dbReference type="GeneID" id="24564608"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212090"/>
    <dbReference type="OMA" id="CPAYAYG"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="556" mass="60501" checksum="449EEBB0AE8A757C" modified="2014-09-03" version="1">MLSNKLEESAVFKSLLSSSSAAKNADLAALLRDRSRCDRLIKSYKGVTLDLSRQLIDSATLDALLSLCHEMNVPKKIEMLFSGGILNGTEGRSVLHSALRAARGTSLTVDGSDVVADVYSVLDSIKEFSNRVRKGSIVASDGKPFDSLLCIGIGGSYLGIAFAAQAFMASSSARRECEGRKIRFLANVDPAGFRIATEGLDANRTMVIVISKTFTTAETMKNAVVARDWLQSNIADPSKFGDHLCAISTNLKLTKDFGIDDSHVFGFWDWVGGRFSVSSAVGMLPLAIHFGFDIAEQFLSGARMMDEHFRQTPLDDNMPVLLALASFYNSTVLGLDCVALLPYSEDLCLFPRYIQQLCMESNGKSVRMNGDKLSYGTGEIYFGESGTNGQHSFYQLLHQGRVVPSEFIGFIRSDNRDVAENGVTFHEELMANFFAQPDALAYGRTPAQLQAAGCSAHLVAHKACSGNRPSAVMLFEEATPYTVGALVALYEHRVAVQGFLWGINSFDQMGVELGKVLASDIRGYFKARHSDWASVEKEGQISYSTTKLLSLFAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D862</accession>
    <name>A0A061D862_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable serine/threonine-protein kinase kinX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768363.1">
        <property type="nucleotide sequence ID" value="XM_012912909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D862"/>
    <dbReference type="GeneID" id="24564718"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300820"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="450" mass="49746" checksum="1180DE6202918C3B" modified="2014-09-03" version="1">MVFNSLTELPRNFREGIDWLVALKGSDAEKNLAAISDAVLNFLRDNSVCYDDIPAFQKLKLITKEFLEQEGLKDRRAVKMILDRFNTPTHKKRDFFSTFSHPIDEDDDDNGIKTWGITAENIVERIAKSVKGCDKFLAEVKIPGKYMSAYSSGATWSNSCTQKPADCAAVFVGITPMLYAGLMSLWDATDADDFRLFPSKAKKNLGDLLNALRYAKPECSSSLSRSDVVNALSGIGIEELDTLMELADFWITQGSENEEAVEDMETEVSADVEEIIEPVNAAESVNALKAEETVNDIEAEETVDEVEAEETVDEVEAEETVDEVEAEETVDEVEAEETVDEVEAEETVDEVEAEETVDEVKVEEPVKDVKAASVKPRVQYVKPVKPRKFYMGSRGVYGIPGVDINMGLLHAWNTKKYHNKRPQISTAAATGNFQCPGAPTVANLDAASPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8B0</accession>
    <name>A0A061D8B0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L12 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0203110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767340.1">
        <property type="nucleotide sequence ID" value="XM_012911886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8B0"/>
    <dbReference type="STRING" id="5866.A0A061D8B0"/>
    <dbReference type="GeneID" id="24563695"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203110"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="165" mass="18227" checksum="E2C67EA655CFE0ED" modified="2014-09-03" version="1">MAKKPDPNQIVYVYLRQLGGEVAPSSVLAPKLGPLGMSPKKVGDDIAKETAHWKGIKVTVKLTIQNRQAKIEVKPSATALLIKELKEPLRDRKKVKNIKHSGNLTWDQLMTVARTMRECSMAKTLSGTVKEILGTCFAIGCTIDNEKPRVLQEKIDNGEIEIPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D7</accession>
    <name>A0A061D8D7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767365.1">
        <property type="nucleotide sequence ID" value="XM_012911911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8D7"/>
    <dbReference type="GeneID" id="24563720"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203360"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="418" mass="45631" checksum="E08AF323A8CEEBA9" modified="2014-09-03" version="1">MVYTSLTEAPHNLKEGIDWLMAVKGDDAGHNLAAMGAAIHKFLVDKPVGYTEVAALEKVKRISKEFLQQEEVTKVPYVNKLLEKFDKPVNKNPDWIARTFTLEACDYKNVVKTGGVEPKEISQDVADIVGACEKFLGNIKASDHYESAYSSEATWEASCSKKPEDCAAVFVGIAPMVNAGIRSLRFASHSEAYNWLPFIKTVNLRNVLKALGYDESDSRYKLGAKVVFKALQGVSYRMLQTLYELSGYWAFYESSTTDVDAEPSVEGEGEQSLIPEAEPSVEGEGEQSVIPEAEPSVEGEGEQSVIPEAEPSVDGEGEQSVIPEAEPSVEGEGEQSVIPEAEPSVEPAGEEPVIPEAEPSVEPVKPEVDDIEKPVKVAKAAKVARSVKAAKKAAKKVSKKARQKKEKKQKKQQESAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8Q7</accession>
    <name>A0A061D8Q7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0302310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768513.1">
        <property type="nucleotide sequence ID" value="XM_012913059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8Q7"/>
    <dbReference type="GeneID" id="24564868"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302310"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="17530" checksum="1CD8F315C9F341F1" modified="2014-09-03" version="1">MAQTARQLSGVTLRNVAQFIDYNNANRLSIIKLVYAPVFGERRLGFATLELRMRLKARIGDRSRYRWLYARNRSRIRNFISGHHGGGARLGLAEQKGRFWAIIMKIHQNLPAALELYYESKNPRDPPKTAYSRRNSLLGRTKNGPFPCHFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8W7</accession>
    <name>A0A061D8W7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0104940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766371.1">
        <property type="nucleotide sequence ID" value="XM_012910917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8W7"/>
    <dbReference type="STRING" id="5866.A0A061D8W7"/>
    <dbReference type="GeneID" id="24562726"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104940"/>
    <dbReference type="OMA" id="MRGAHLM"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="545"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="621" mass="69141" checksum="53B86734060E1788" modified="2014-09-03" version="1">MSKKLHEQFFRCHPKHPGSYTSAREVEQWLATYLPWLILPQFKRPELGNISLIGAKDRKLLRARLINALSLDDTQADALLPNKTPITYSKVSGTRHLVYIAGADPWLVQLQDGRMFPTIYALWSATDLLPALRIHRAVLTYVMRGAHLMIPGVLNWPCDIKPGSMAAVVVEGSPFPVAVGVYEGSFDERGNVRTSGRAMEILHYYTDGLWLKHNCGDRKMSSKALPSESSSNDEINVEQGGNTSQSEKSKLSQPHQIQNNTSYVDVTNLQSDISAETQNGSQQQVDATNTAASGQSAESSCPKSENAPAADPYASPQGHDKKSTESVAFNVKLVDHVLRLCFLQTIHGITDAQLPMEISALYSQMTADGTRLLATSKFKQLLKQADLWDDNISPQYSAQLISYRNSSFKKLAKMFQTWAKEGIITMKDLRGTATVVNINRNHEAFIQFTPINLVHLKEAGTSKNDKVRVKRFLAFSSSQRKAMAERGLNVQKEPMPLEQFKQFIIDHVTKEGDAILAFVNDAAQYHQVLRGEEASAIRKGAVQPVTVTIEPRGNRKHITIVKGLFNFLFNVDESAVAEALRRKFASSVSVNNGVIMIQGKVEIKRELVEQFGLSQQHIQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D909</accession>
    <name>A0A061D909_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769372.1">
        <property type="nucleotide sequence ID" value="XM_012913918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D909"/>
    <dbReference type="STRING" id="5866.A0A061D909"/>
    <dbReference type="GeneID" id="24565727"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310890"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="120" mass="13324" checksum="A5D4AA8EC71D4F03" modified="2014-09-03" version="1">MVPSKNDEAAITASQYHWLYNRLYVTTCGTNVSAIGSHHIDIRGYLATVGLCGIGDAIILLEFRLGITESITYLAEYFAKAYVINFTHDVKDQDSEGRKSDDASKSVAYALPRLFPTHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D941</accession>
    <name>A0A061D941_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIBOSOME BINDING PROTEIN-1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769249.1">
        <property type="nucleotide sequence ID" value="XM_012913795.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D941"/>
    <dbReference type="GeneID" id="24565604"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309660"/>
    <dbReference type="OMA" id="CEYGSEA"/>
    <dbReference type="OrthoDB" id="6410656at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1305"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1379" mass="150653" checksum="D4DC830A9BB174F9" modified="2014-09-03" version="1">MAKITSKIPALNNLKQCLQFLEWLKNDEHMQGQVAEELARRLRIYYSKNSDSQNIKTALSRLLFQVSHFYDKLCKNAQPTNYMANTPSVVLFTLLACIPKLLSVVYFLQYHVDKRFVAVGGGDWADQTIGMVAMSTSGVSKIDTYLIDTSFVKYGVISGGFEKGRLKEGSDGGYTYGTEMVDDLPKLLGELHTNFFSDVLVTSALTNAGSQASNTANALALLKTFCEIVDDDKDRKVENALDGYINEYRNCIEWEKLKTHCAELRVSLERIFNAGVLSNTGHSPAVDDLNKEKFAKRMTRWLRENLDRVGSSLKEIKANRYTNAGDYFNKHFFPYGFIFDSHDFGTESYRSQVLDQKWKGVVEILSEYGRELDKTVNILKGVSCKDHNHVKTADLEADDEEDEVVVLEELGVSDDLGVEGSPNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGSPNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEAASDDDDEEDDLADAASVGSSNQNNGQSEHQPGMSHTSLGSNVPPEDGKGPQGHAGPPDDAGKSLQGSDPPAQAPALPQAPGVKPSSSSPGGHGAGGAPGAPGSNGDPGQTGPTSMVASASSQGSDAQGIQSPQPTLQSSPASFPTPPASPTGSPKLTAQAAVLGGGLQNASLGSQHTVSSQAVLTQAAKDSSRQSAASGSLAPGSGQGQDLPKLEVEILKPKLISSEDAYNSSADALISDHIERSRYRNGINPPKDPLTVSHTLGKASPQSDIASDLDKLQEASVLSNSLDLRDVDMPFEHFDFHESPNEGGTGEVYIPQCLNPWYVDPSSTSTRHSTTSPPDSDNMPSPNTVREMLYWMVGVVELGYIGFIQKHVGGVLDDINKDSSWPSFAIDVTGYPNQLTASRVTNTLAEACLYSANIITRIKYYNDFKAFSTFDFKSVYSQLHYSSDPSCLLCQLRDYAYACHYQLQFLKSQCSRNESRGGWKNCEYGSEAKMPSPLQAFLTDGWDSDFKTHLFDPCNLCLKSRVRMGFKRRDLPKISKQGSVISTILSPTCGGEDPLLTLSSYLNCLTRRTPRTTGELVSYFHHFGIELHDYASKALSSLGTAITKSHANCPNWDQLGDSDLQAVQGIRGYETLNSKHNHGNDHSNTLSTLVGCCSDSANCPQYCSPITYRAYSLYSPTFAHTYLSWAVYLPDRLWESLERLRYDFKTHTCSEPKSFHQCSAAMPLLYTHGFMPPEGKLQWPLTCSDIIVKLRTVVDGKPIAMLITCMDEFLYRVRGPFIYTLMALWSGAILFMSYTILYRLDVLYLCSHFIRSKASHLIDVKALLTNSRKMLSLYDADYFDDDPNDLIDQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D965</accession>
    <name>A0A061D965_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial intermediate peptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768708.1">
        <property type="nucleotide sequence ID" value="XM_012913254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D965"/>
    <dbReference type="STRING" id="5866.A0A061D965"/>
    <dbReference type="GeneID" id="24565063"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304260"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="149" mass="16325" checksum="AB31A5960CB89B85" modified="2014-09-03" version="1">MQLLRPTTATIRYVTGCSKAVVSLRTSTPPSSHHCRTFVTCPKVERSLFYLGAKTPSDLVRIGQEAVAASSDIIADVGDRPQDGDVEGRDLIYTIDHISNTLCLVADPCELLRHVHPDDEWRAAANATVEEVSAFISRVNIDEKASVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D971</accession>
    <name>A0A061D971_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cwf18 pre-mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0206120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767640.1">
        <property type="nucleotide sequence ID" value="XM_012912186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D971"/>
    <dbReference type="STRING" id="5866.A0A061D971"/>
    <dbReference type="GeneID" id="24563995"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206120"/>
    <dbReference type="OMA" id="LPSKQNW"/>
    <dbReference type="OrthoDB" id="363869at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14239" checksum="1AEE0F2612DD36FF" modified="2014-09-03" version="1">MADKLKSLVFNYYVPKDDNLKRLVRSNLEDYRKIEEEIDAAIDKTIEEYSSKDVLSLVLPSKQNWDLKRNLQESQKLLAMRTDMTIMKLLQAGRTKEEIDPALMVQFNQNGMERDLEQEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D991</accession>
    <name>A0A061D991_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767665.1">
        <property type="nucleotide sequence ID" value="XM_012912211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D991"/>
    <dbReference type="GeneID" id="24564020"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206370"/>
    <dbReference type="OMA" id="STTIDLW"/>
    <dbReference type="OrthoDB" id="365615at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="101335" checksum="F007D1B675E71DA6" modified="2014-09-03" version="1">MYRKRAMPPQYSRSNDSNQRYRNICIQYLILLLFFALQQVILYYPVYYIRNERRILYVLILDAFIVLYLLLGTVSARGHSATCVAIQWRLCCTSTLIKLCILLFVSHEGASSAFEASNRFAAENYLAFIGFYLTPIMYILFNRMSNLFLFNRQKGNVNVDELLHSDLALATFVDMWDVVSMLDHLLREFPASVRTIASGRYRSVYAYAKSSSVVSPESRNYTAYAVLCVCSIFLLGFVAPTVDSDLDVGSGDLERRRLFWSKLVDRLCCCRRRNNEKRVDDGDPDSVEAQGSVKPHVMKMSPALKGQYLDMFTIAKFTFLIGFCLIDVPFFIYRLLHLLQENVLSIMIYKNLLGMVMRPYRLALSQLAERDSAKGWQSAFFEAAPLPNDPATKRLIHDDLKLLEESSDSENERQFSRKFTDRMMKRGKTSLMSNLRSHTRSMLNRIGSFMLRKNSSARQLKPMKTTLPPKPEPSQESLDESSPRGEHAPTMLRFKSQVESESNYDDWSSTFEAETTSVSDAVLSEKNVENERRDLLVRMLNHQRTLPVTTLGFSMIYRKCCDALWRLFKAEPSFDMESSELLLFERSFEFARMLAAIAVALLSRAIIVICCYNSYFSVRSPRFLFGREVTTASRYEMVLYGVVVFAPLIQSALFYRLQRCGWFGCLCLWVQEAVNLCSYVTCVCCLRGFVKTPNSVVYAMEIYALLQWPLCVLMTLLVEVLRNKLNTVRLIYVLCKHGMCPVSLNHTLFCNDLLKNTTVCDLLLESQWNYFSSSILFRSLCCSFSPTKTEVVIILVDLLLRLMYIICCQAMRVMMFRKYEIQYVMLRMANSISFDYQAPGETFALSSEYRSRFITPANLDAYICEHGLLSSPGIIYPPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D993</accession>
    <name>A0A061D993_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769299.1">
        <property type="nucleotide sequence ID" value="XM_012913845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D993"/>
    <dbReference type="GeneID" id="24565654"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310160"/>
    <dbReference type="OMA" id="KFTIEWG"/>
    <dbReference type="OrthoDB" id="364112at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="271" mass="30838" checksum="D752A40874B14F97" modified="2014-09-03" version="1">MANDDLEHGLFEDSEESSVEDNTAPYLTTVEDPPTQEFAAPAAEAVAALEVKPEPVTRKVINKTIPSSAYPVRDHHLVICKFPLAVSMSASPFTEMEERQRLRQNPKLLEEPQSSENAAMMRWRFGQAPEGDSEPFGVLETNTHFVEWDDGTFTLFVGKTPFNVDYRSETVFLLEDSRPDLKPVHAVITDRLQMKFSNILKNKFTRSKDVGAKRQRMTLTSIADAVSSKISLQRHRIMVRENERFRRIQQSTTYGPRGLTRQFLESDSDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9I7</accession>
    <name>A0A061D9I7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0305550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768838.1">
        <property type="nucleotide sequence ID" value="XM_012913384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9I7"/>
    <dbReference type="STRING" id="5866.A0A061D9I7"/>
    <dbReference type="GeneID" id="24565193"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305550"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="79" mass="8752" checksum="B51D1C83E36E0A59" modified="2014-09-03" version="1">MINDDGKLVDLYIPRKCSATSRLLPAQDHGSIQVNIGMTDENGVYNNQNIVLAISHKMRLGGDADEAMNRLFKEHGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9N5</accession>
    <name>A0A061D9N5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769429.1">
        <property type="nucleotide sequence ID" value="XM_012913975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9N5"/>
    <dbReference type="GeneID" id="24565784"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311460"/>
    <dbReference type="OrthoDB" id="366620at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="238" mass="26620" checksum="A36DA4908C5D4265" modified="2014-09-03" version="1">MVYNSLADNPWNLKEAIDWLVALKGTDPSTNFKAMGAALYDFLGQQPIVTRSVTTIEELKRVSDRFIGQKELKHHRSSSVMLERCNGSVEKNTGEFADAMGSKPEKVADNVANVVYACEKFLYALRRPGEYTSAYSSEATWARSCSNDPEACAKIFVGIAPMLYTGLLTLMDASNATNSVWSWLEERQRVVDVLAAGGYTKWDCRHDMSFFDLSKVLSSIKKETFIMLYNIAGVLAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Z3</accession>
    <name>A0A061D9Z3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0108630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766751.1">
        <property type="nucleotide sequence ID" value="XM_012911297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Z3"/>
    <dbReference type="STRING" id="5866.A0A061D9Z3"/>
    <dbReference type="GeneID" id="24563106"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108630"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="154" mass="18023" checksum="4CB59CE51780651A" modified="2014-09-03" version="1">MIKFFMAISRQCKVRLAKWFVPVDSKEKAAMMRELSHLVVNRNSKQCNFIEWRDDKLVFRRYASLYFVVCVDRDDNDLLMLEIIQHYVELLDRYFSNVCELDLVFNVNKAYYLLDEILMDGELYECSKKAVIRSVAAQDALCDKGRGILSKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA52</accession>
    <name>A0A061DA52_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0400880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769782.1">
        <property type="nucleotide sequence ID" value="XM_012914328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA52"/>
    <dbReference type="STRING" id="5866.A0A061DA52"/>
    <dbReference type="GeneID" id="24566137"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400880"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="271325at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000501">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="9">
        <location>
            <begin position="357"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="765" mass="86362" checksum="9A7165D19FDE3EF0" modified="2014-09-03" version="1">MALSSEEAQQRVSLMGAHVKALAHFFETFSAPSMVSEEESQQQIWGDRRYMNQLQDVKNCTSRLLKVHIGDIRQHFMKDTNERQVYEGVMLNTYRYLELMYAAADMCLENIEKSTSADNDSMLGPTGNGTDNSVIDSVDELRERRMRNSNLPVYLHSNYEIWLLPGEDDSVMKMKSVNADYIGALTLIEVDVTRVGLLKPRVQVATYECDSCHGHTYKAIQGPHFLPVSDCVECTTRNNARGTLKFHSRLSKFVKYQEIRVQEPLYHLADGELPKSLRCELFGELTQTLRPGDSALLYGILLPVVHNVFNPHRSTLLADKVFRVVSLQHQKKALDATTTSDSELARRIEVLRSDPDLYERLAYSIAPEIYGHDDVKKALLIQLVGGVTREKSDGGVIRGAIHILLLGDPGVAKSQLLKKACLISPRGVYTTGKGSSSTGMTAAIVKDPQTGETALEGGALVLADTGLCCIDEFDKMDDYDRSAIYEVMEQQTVSIAKAGHCSSMPARSAVLAAANPVNGVYDVRRSVFQNMNMPAALLTRFDLQFLMLDRVDRGKDAQLAEHVVDLIKGVAQEQRPKYEVVDKELMRSYITMAKQYEPTMSQEIIEKVSDWYVQARQQEQESEMYNDERFTYTTPRSMLAVLRICQALARIRFSNVVEMSDFEEAVRLTGQLRASLTEAMQDRMSSRRHTSTSEVMHLIRRRRDELRQQEGWDGWMLVRDIEQQVLASGLKRKDLVDAVARYTRLAVIILGRGDSQIAFPEDLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA88</accession>
    <name>A0A061DA88_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0313600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769644.1">
        <property type="nucleotide sequence ID" value="XM_012914190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA88"/>
    <dbReference type="GeneID" id="24565999"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313600"/>
    <dbReference type="OMA" id="STRNACY"/>
    <dbReference type="OrthoDB" id="361463at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="198" mass="22239" checksum="27DC417B19875956" modified="2014-09-03" version="1">MDAYERFNILSATFDPESLVDENENLPFDPSRDRFYLSLLSSVSDEKLHKAVLGLRDSRLAVGRLPHASFLLPWSAQPSSEFADSAASGVRSQHPKTGTQLKASLQKFVSRAKCEAEAVKHMLELRLTGYTSTRNACYKFLRDALKTNREVVVCLRLSGVVPAVRCRGSVVFFDRSSNMLLSDVEVDGKVHHPFMYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA93</accession>
    <name>A0A061DA93_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769073.1">
        <property type="nucleotide sequence ID" value="XM_012913619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA93"/>
    <dbReference type="GeneID" id="24565428"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307910"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="75" mass="8377" checksum="38CE93AA2D11ADFD" modified="2014-09-03" version="1">MTLQPTPHLPAPLAVPSTCKHINHLSNALTNCNTYHCRSQSPQPANYQSLKQRSHQPLINTHRSKGTDRLPSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAA0</accession>
    <name>A0A061DAA0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0308010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769083.1">
        <property type="nucleotide sequence ID" value="XM_012913629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAA0"/>
    <dbReference type="STRING" id="5866.A0A061DAA0"/>
    <dbReference type="GeneID" id="24565438"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308010"/>
    <dbReference type="OMA" id="AVYQEHK"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="126" mass="14445" checksum="9AC83426623843E7" modified="2014-09-03" version="1">MADRSETDSPDSLAERQFEIANLRARFHNRIPVICIAKKFSTLHIDKSKFLVPANMMYAEFKYILQKHLVTENIEKPEYVGKNAALYLYVGGIIPMAQALMGELFQKHRSEEGVLYMTYANENTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD5</accession>
    <name>A0A061DAD5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YT521-B-like family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0308410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769123.1">
        <property type="nucleotide sequence ID" value="XM_012913669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD5"/>
    <dbReference type="STRING" id="5866.A0A061DAD5"/>
    <dbReference type="GeneID" id="24565478"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308410"/>
    <dbReference type="OMA" id="KNNYCAD"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="7">
        <location>
            <begin position="255"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="436" mass="49176" checksum="429BBA9466A17FA0" modified="2014-09-03" version="1">MDLYTTLIEQSTGRARREDDYDAEPPKEHKCNVLMSLALSVVKRESEKAALLKLKGYERADIERTRGKHSVVCRHWLKGMCMKGEFCDFLHQLVYSRMPPCRLFEKNGFCIDNQRGNCIFQHVVEQPDSGPSQDPRIKEAIANGINFAEISHETDPDGFATAFVLAISTVFPKISDLAIMEEAMPPSPQPQDLAEPVNENDDGDAALANASDVDVNENRPLISASIPGLVKFDATAILDGERRSRASFDVNSNNTKCFMIKSNNMMNIYFSICYGIWATGINNTMKLVNAFQKCEHVILIFSGNESGGFQGYAKMMTLPIPGLYQGIWGSFHSRLGDNFRVKWIKQCSVEFEVLRHVTNQYNQNLPLKKSRDGTELPLDVAETICNTLYNAPEDDLLKGTPMATWERIDHETYFDELNNKNLLYTTFGLPFTPINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD7</accession>
    <name>A0A061DAD7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769699.1">
        <property type="nucleotide sequence ID" value="XM_012914245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD7"/>
    <dbReference type="GeneID" id="24566054"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400090"/>
    <dbReference type="OMA" id="RIIYYIY"/>
    <dbReference type="OrthoDB" id="360388at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="510" mass="56513" checksum="B4785EFC53AA0D6C" modified="2014-09-03" version="1">MSAAGVQREGTVLPTVKLSELTSRDDIDDDLTDTILVLRQTESPSDASSEDIVINVHSGVLRVASPFFMRAFNDIQSTERIRQDLGGVCQGRIKYTLVTPHPLAVQRILYYIYKNDYQNVTEEPQLLVPMYQESARFGLADLKQSLLRIIRSQQSLQVLASLSYAAESSGEVELARDCGRVLADAAFAVFSGGLLQRMGMAAIKALLESDNLQLDEVQTFTALCQFLESNARFVSPYASAPIGPKEKAIDQLRHDNLSSLLLDAALRILQGATKKPRHFPWTDNADYTCMTYKGLFPVLVVRASREQLGLFDPNTGNAKLVTPNITKLQSDPRSGLSFTVGTEREMSVCCWAYEVSKTKSGNIAFGIAFASQDPIDDESRTCFVSMTRSRRVVFYYEFAEDTFKSGYIEPGANRQIKAEWTYESKPGQYPHNLKQRDIVTVNVVVATSCVAFSVGVLGTSLKRSFQIPHRTSGVLGSVMRKPCIVGAPFFMLHDMGDSLCIPELRADFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAE2</accession>
    <name>A0A061DAE2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">GTPase Der</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0400130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769704.1">
        <property type="nucleotide sequence ID" value="XM_012914250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAE2"/>
    <dbReference type="STRING" id="5866.A0A061DAE2"/>
    <dbReference type="GeneID" id="24566059"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400130"/>
    <dbReference type="OMA" id="MRTDKRT"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01894">
        <property type="entry name" value="EngA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01895">
        <property type="entry name" value="EngA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTPase_Der"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834:SF2">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596140" description="GTPase Der" evidence="9">
        <location>
            <begin position="19"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="10">
        <location>
            <begin position="72"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="10">
        <location>
            <begin position="249"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="GTPase Der C-terminal KH-domain-like" evidence="11">
        <location>
            <begin position="424"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="530" mass="59196" checksum="53809CC15D4EB8F4" modified="2014-09-03" version="1">MRFLSISLIVVAHSVVYGFLQPCRECCWALSGRSASCRRPAVRRAHFQPSGEGEPQLQEPDDRVDSPCEPVVAIVGRPNVGKSSIFNRISKQFHRGSIVSESPGTTRDRQYALADWEGCTFRLIDTGGLEDESEYAESIKAQVGDSLDHASVAIVVVDGQEGLTEGDLEVRDFVLDALKKRGNLRVLLCVNKCESFHFGDVLAEQFWRLGLGRPYPVSALHGTGLGELLNDCVAGFGRCTIEERHDVVVSFVGRPNCGKSSLVNLLAGSSRCLVSPKEGTTLDTVEVPIVRGEQRYLLIDTAGMRLQSKDRRSFLPKGRSLRAIRRSDVCVLVVDASWGISRNDVKLAEEIRAESRAAVIVCNKWDLVDKDPTVYKNAVSYVKEKLHWLDYADVVFTSAKTAQRVSNVLEACQNAHEQFSKSFTTALLNEVLREATFLQKPPVTHGKRLNIYYVCQVHSQPPGIALFCNDERLLTDDYAEYLEVFFRRSLNLTGSPIRWYPRAKRARHRVPDLRNRASKGSCNPRELLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAG7</accession>
    <name>A0A061DAG7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769158.1">
        <property type="nucleotide sequence ID" value="XM_012913704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAG7"/>
    <dbReference type="GeneID" id="24565513"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308750"/>
    <dbReference type="OMA" id="RFLKGIW"/>
    <dbReference type="OrthoDB" id="360266at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1052" mass="119162" checksum="A50422A7C8538D49" modified="2014-09-03" version="1">MDLLPRGDSRLPAKGRGMLSVESTTSGAVVKQYGAVFRPPEVDSDETPLIDPADSTPETMFSDLTQFMQDPRSKKTVMWRYPFLRTFPQRAALRTLTDFMPASRARDCLNVTDGSNVDDLLDPTCQGYYCKRHIKAFFRYQPEFNYMRNGTEVFPRTPEPPKLQLPSDMPPTEGSKERPSVPLGWRTFAALGLYHTATGVSDPAVLWSGYRLTDGDPMGRLASGLYNSPLTLRVLSGRDAVMPNNNMMHSKYPIEQGERFRGNKGDMSHLGPMAPRHHETISEDLYRHHFAEDGVWPYKHFETVLSEMVPSQALWARLSTTLLRSTAKVLRMYKLRVRKNFKQEVFSARRTTILGRPKPPSEVPVETSVGVLYFLTAPTLHHAVGLACSDPMARCNLYQQLLLFEVDDVLKYQIFKKRDPNRENPRQYVVLGSYDHRDDHKLLRDKMMRFVVRSNCVNTHVMLHSPRKDAMVDLSMPLQQFLPITTQQRDRLLDRLNNVRDACNTKNKSLPIGDLSIINQFDSDDAFDWARRSPYTRAGCYESLFVAKAYEVGFYGRNCHYVAPLPMGSSLMPVKQEYAIIERDPVDVLRDRMSDGWGHVLALPKVIPRSSELYRELAAGESVGVENVRDEHSEQRVDGATESTPPESGDAGTDPAQQSWPGRLRITIRRTVSECFKAPNISSKHIASTRPIVEDKAKLGDVPFERDGSLAVEMPPPRVEDTEGASRSQDKLNGPLESQMGGITRGRMYVVGRPGKQEVPGSVQMLPGVLLSTDAVGKLLSENAPVELDTPFFADLLKDYVYVSLPAGDFFECPPGDDNVKYNERGEESMIQTGVGAETTNRLPKNRPEAIAGFWIKKSECYLMYKNDEERCMLLGKAPSRLDRRRTLSQDMIKRGLIRNEVILDYIRKGAGLTWPDLSNAYSRREGKLVSHLSPTEEMKTMWTVDPLNKPYARYSADDEVPAARFYLKPVEYAEDDPRQRMRRYPQELYKMAFEFMQKVDRGEAKPEDDPLKALVEAEYVLPKDSNDSICTWEEAELEEAKNAPVQGTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAH2</accession>
    <name>A0A061DAH2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769163.1">
        <property type="nucleotide sequence ID" value="XM_012913709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAH2"/>
    <dbReference type="GeneID" id="24565518"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308800"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="168" mass="18369" checksum="00569E31C29EB416" modified="2014-09-03" version="1">MLSRLIVYYVAKGLELVLGFALLPPHADTGSGLQVGPLPTVTGTMCWHLPCSTTTVIHNVVIIPESHILYHTTTISNPVWYVNALSPSFNSSLDILILQVSISTRFFSLVVYHFRANDTTPLAECRCVPVKGAILSTIQIEDYYSNVGLEVLLVTGLIQIYYSLVGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAK7</accession>
    <name>A0A061DAK7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768120.1">
        <property type="nucleotide sequence ID" value="XM_012912666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAK7"/>
    <dbReference type="GeneID" id="24564475"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210840"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="69" mass="7696" checksum="90C7AE04C2688393" modified="2014-09-03" version="1">MPLSQSISIGDLGLILLKVQTVMEFLVIITDKLIGDGPVAEVLEYRLVELYELEQATQELNTTTLEALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAL4</accession>
    <name>A0A061DAL4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769779.1">
        <property type="nucleotide sequence ID" value="XM_012914325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAL4"/>
    <dbReference type="GeneID" id="24566134"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400850"/>
    <dbReference type="OMA" id="HNERSDI"/>
    <dbReference type="OrthoDB" id="365977at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="173" mass="18931" checksum="A1A6C49932155F05" modified="2014-09-03" version="1">MTEVRRIPGSKLLITKALSCVQKTLSVCEGLTAVADVPHLLEVAQRPAPIPAYAFTTTSTVLSFISIEQDSGRNASDTGAEKYIAGDPTGCIRVLFPSHLKPTDSPAGKTYVVTDVAIAVRSGVIYFEIIEGTRLLLCQGRPEFHVRRDNDVSRNCLCEVQHNERSDIMQFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAR4</accession>
    <name>A0A061DAR4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769268.1">
        <property type="nucleotide sequence ID" value="XM_012913814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAR4"/>
    <dbReference type="GeneID" id="24565623"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309850"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="95" mass="10055" checksum="5791E67832C322B0" modified="2014-09-03" version="1">MAILALKSGRTFQDLLIGPAKAAASLLDARNTIDTPGSELVVALPLATTAIRCNHAAPGMLRHVDTVYLLEVTSKAVVVHLSTTARRRDPSGPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAS2</accession>
    <name>A0A061DAS2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA export protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0402690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769967.1">
        <property type="nucleotide sequence ID" value="XM_012914513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAS2"/>
    <dbReference type="STRING" id="5866.A0A061DAS2"/>
    <dbReference type="GeneID" id="24566322"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402690"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="358" mass="39917" checksum="5F8B8019766A8C56" modified="2014-09-03" version="1">MAYSRGSNDDPKTHFLTGLPDDSISHISWTHTANPLLLGAGSWDKSVRLWRVAPAIGNMVTSESVMLYRQEAPVLASCFSADGTKFFAGGCSNTVMAYDLVSRNPTGMLVAKHDKPVIGVYWVQKLNAIMTTSWDGKICMWDGRQQQPMWTENIETKIFASHFRPNIVCVAGSNGKIHAWNLDNIQHAKSKVTLDSILKCQVRSLCLFPNVTDKSGIVYTSIGGRAVVSYFTEENRSHNFSFKCHRQDVPGKSAQIHPVNAVDFHNVHGTFVTGGGDGVITIWDKEHRSRVKTFNNVDSPVVDVKIHSESNMLAYATSYDWYKGLDQDLLAKTRRQIGIMQLRDEDVKGRPKTIGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAY9</accession>
    <name>A0A061DAY9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770012.1">
        <property type="nucleotide sequence ID" value="XM_012914558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAY9"/>
    <dbReference type="GeneID" id="24566367"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403140"/>
    <dbReference type="OMA" id="ARIYKRG"/>
    <dbReference type="OrthoDB" id="368507at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="110" mass="12505" checksum="63AC1E604FDE19D0" modified="2014-09-03" version="1">MEIHKDSFTVYDKTLNVLSVEYESGLYVWVGDDSKACRDLHCGFPVNRLKDETSVGSTLIGDLDAISSDLAKMFVFLSCNVEETDNTMLEVLQEELIKVLTRMYPQYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB04</accession>
    <name>A0A061DB04_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">-CUGBP Elav-like family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0403340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770032.1">
        <property type="nucleotide sequence ID" value="XM_012914578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB04"/>
    <dbReference type="GeneID" id="24566387"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403340"/>
    <dbReference type="OMA" id="TLWHVYK"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="208"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="310" mass="34757" checksum="98F98D00D28A7575" modified="2014-09-03" version="1">MDRSPGRPVRYIPRRSGNSNSDDQNENTVRVWVGNIPPSVNFSSLISALRECELPTWTHVLLRKGAHRNFAFISFTNHEDATLCAQILHHRRVFPDSDLPLKAQLETPRDGGDLSSTTANSDDLKVTYGGNRQRSGYRRNMTSTTHVYEMLQDADESTLWHVYKNEDGIPYYYNHITGCTQWESPVPPLVAVANSVNERTRGVSPDGANLFIFHIPPCWTDKDLAMHFTPFGNVVSARVQKDGNGHNAGWCLLALMSALFADTADWHSGFGFVSYDNCQSAAAALRLMKGYATNSKFLKVEYKIKDSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB12</accession>
    <name>A0A061DB12_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stripes inner membrane complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770042.1">
        <property type="nucleotide sequence ID" value="XM_012914588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB12"/>
    <dbReference type="GeneID" id="24566397"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403440"/>
    <dbReference type="OMA" id="CKNYASH"/>
    <dbReference type="OrthoDB" id="445338at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20558" checksum="1FC17855D0B14A9C" modified="2014-09-03" version="1">MVECQMLEIQDDVNSLVRQAISELRKPQPARPEAEPLDNQLVEDIFEHINEAIAKKQPKNIIKFVVDFLCEHYPDHLHGFSKLWKSDPELEANRLKVLQFFNYFHLPVQVACHFTNAGFDTLDTILTLNRDSLGEIEAYSEAQWLPGHKVRLYSIFEDIKKHVEEFNRESQYMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB25</accession>
    <name>A0A061DB25_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769929.1">
        <property type="nucleotide sequence ID" value="XM_012914475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB25"/>
    <dbReference type="GeneID" id="24566284"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402320"/>
    <dbReference type="OrthoDB" id="366787at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="349" mass="39386" checksum="CB9C88332B8BD9AC" modified="2014-09-03" version="1">MAKSTLITGWKRIVLVVLVLTFGNGTTAQINVKRFRHTLNDDLRIYVNGQRTLYSEIQFEKEPTKHYMFALKYEHLKKTTQFLRDVFTHYQGLHPFKPYLGMIVEFYERKLAEANGSSFFELKPNELCAEVAGSLTGITDTVVELSPLYHLNRPDVIDAISCFRSAPVKAQEDMMDFWMLLYQSLYTKCSETLQNFDMENTVNGFQVESGVTTPASLRGVGDTIGYDEPAFVDLIEHESDEAPWLREDEAGASPCIAGSLGAWKPETDRSLEASDASGEMAGSSNDDRGCDNISGACDSRTEHHDFDSSSDSYFKPEKPEEDEDPLWDEYFASFLMRLKNRSDQSGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB38</accession>
    <name>A0A061DB38_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0403790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770077.1">
        <property type="nucleotide sequence ID" value="XM_012914623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB38"/>
    <dbReference type="STRING" id="5866.A0A061DB38"/>
    <dbReference type="GeneID" id="24566432"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403790"/>
    <dbReference type="OMA" id="GCTAKYW"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="47"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="392"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="568"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="717" mass="78805" checksum="DD21BF40026E08C6" modified="2014-09-03" version="1">MLFVSGLTLFFDRSGERRPPSRTRRLATGIWNRFTIPSFFGRKASCCGVVAYVGSEDCRDVLLDDIQSIKHRGYDSCGIGTLNLDGSIEVTRCSSYKAPANCFERLRDRIGDRHLGSKIGIAHTRWATMGPPTDENAHPHCDAMRRVALVHNGTVTNTVDLFNETCAMLRERGLLLERLYGSEPRCSDSDSAAIANIIGLHLDLGYDAFSAMKTVVSRLEGSWAICLISANNPHALYVARSGCPLLVTKNDNTKSVHVASETVAFMNHADQFVVLEDGDIMELNYNTVVELFRTRKVCNITRLQVRSTPEPHEFWIQKEVAEQPLVARVALQHFKLVRASRELRAIKQALEGVVDVTFDSDDHLVDRDLELVSALDPRNVRFEIPVHGDASLLKKIEARRKINIVAAGSSLHAARYVATIFQARRIFALIETDDPTEMTPYRYTHPDSTVIFVSQSGETLDTVKACDMLAASNPSAVKIALLNNLNTLLDRSCELTMMINIGREVSLASTKTFSVQIMLLMVLLGYILQAQDTEGRQADFLAQLKASIIGFGPGLKKMLATAPQCERIARRLVDVGSLYVTGNAEAYAIASEAALKFKEVTYIHAEGIPSGAMKHGTLASIDSKTRTPVVCIITPDEPEAAVNAAKQLKARNAYIILLAANPALADIADEFIQLPDCGMLTAACAIVPVQMIAYNITIMKKRNPDTPRGLAKTVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBL9</accession>
    <name>A0A061DBL9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770139.1">
        <property type="nucleotide sequence ID" value="XM_012914685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBL9"/>
    <dbReference type="GeneID" id="24566494"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404410"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="321" mass="35892" checksum="FEF56CB40FEF0740" modified="2014-09-03" version="1">MVYTSLTEAPHNLKEGIDWLMALKGTSGENTLMHMVGTIHHLFSDHSAGNNPLPSLDKIKRISKKFLEKPELRDNMLVKKVLEKFNPVDGTANTGFRRYWHKQFDEYGRVVGVKGAKPEYIEECLSNVMDGFEKLLDDIKNPDQYESAYSAEATWEASCAKNPEDCAVILVGIAPMLYAGLISLWGTSESKTGEFHRFAGSRSFGEVLRALGYVQPQCRADINGSKLFKNFEGLDDDLLHNTYDLAGFDVFYGSKKAAVKSGKLDKDAQDRIDFYVNMKPINPPKKYVLRKQPNTVSAIGSKNFYYPGVPTVANLDAAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBP1</accession>
    <name>A0A061DBP1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0203220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767351.1">
        <property type="nucleotide sequence ID" value="XM_012911897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBP1"/>
    <dbReference type="STRING" id="5866.A0A061DBP1"/>
    <dbReference type="GeneID" id="24563706"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203220"/>
    <dbReference type="OMA" id="CKINSDL"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="52"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="309" mass="34377" checksum="8C8F7F6FF0A1E9A0" modified="2014-09-03" version="1">MGLFEYLSSALSVAVELNYYVLGAGALYLLAKIVEFKAISRFGSGDELFAKRVRPGYSLVLDLDGTILHSVQTRGNNTTSSIALNVGKRVRHFVVYKRPHLDTFLMEMRKRYEIVLYSASQPLYADACLNYACVNHLFDRKLYRNDCIVGHGGAFVKDLCKINSDLSKVVVLQNPLQSNAHISANSLFIDSWSGGRHDTALLDIMPLLQALSHVDDVRHILALRRSGQPEFSQRSVTPQEKLSDSAATPGEPFSAAGRAEILGELQNWDNIGARLTTRVKRIFDTMGPDTTLHMPAPRDGPPRFNKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBX4</accession>
    <name>A0A061DBX4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0313840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769668.1">
        <property type="nucleotide sequence ID" value="XM_012914214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566023"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313840"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1373" mass="154479" checksum="6E6848A16A3535AB" modified="2014-09-03" version="1">MGFLHGVLEAVKNENEVTTYDKYISDHNKNLKSVLDTLTKNIGSGRAGLVESVGAVKEWLEGYGREVEEKINRVKNLLEQLKSGINDALQVRQNMNNYAVDQQQEWSSKIAHILIGSAEQAMKAAKHLDQNLKNKLVKYIEFVIQAVSNFCESAKNEDMKKVVKSVEAERLLLLSHSHRIRDDAESTVNSFIEMLEQNINKLDGQIVIVARNISSAENELNGLIKTADEAHKLGKDSAAKLGTLDTKLRSELQPNIQHIPFLTMSLGVKTTESELFELLKHIDAEIVKLATNVNTLGNKNFNGFLSKMKSDLEALHATIDDLHSTAQSNSLLRPTRQHFVESARRIKIIIENVSKSLMNDVDETLRKLEKKVETLQSTFEEDKQSLDELAKQISGTVISDILKESTALKEKNKGLPKINGLISGIKLRLNTIHQHVIDMQSANVSSNMRNVQRHFKVAKQNAIKDIAEIARKLELEINKVSYTVYETARETYHASKVAELKGLQSFVEKQKSTIEHIIYTDKMTGVKGLMRILNIALKSRSFSDMTIMNELVYKLLDVFKLFFHELMNQADLKESADAINTIYFASKYLFDKMFEEKHFHTDVTKKLDAFSNVLSVFHPETMDGAPKKVLTPLKQGFGKFVDQLDKAYVSRYSGAKQISWEAHLTTAQTEESKNCAKVFLTIAPTLFGELTHLRAQCASNYPASKIHATSGPGVLLKRMGYGVATDKSAQDGHLQNSDDMRGEKIVRLLQRQIQLSEQIAHSPKCVTRNTEKFNTMDVLDCVFKHVDEYNAVCHTTPVAKPRTPCSIFEMLGWFCGLPYNSVHTELISETLYEYLENPNKPDKDDEEGFEIEIVDHKSLYLQAYPHDITYNAIVAALTDICSTSYDIMATVVGTGDEYTMYGCDYSNNTLGLYYPQSGDDCLHMILDLLRRLFPALQYIRVQCKVATKHGGWADCAYGKSVSPANWPSEDHSTNEPKSQPNDQPKMEPKCQPKSPLMSYLNDCLPGHMPHQVSSTGCKSKCSTCPRNVPGMPCLTPLGFRGFSGSMKKGSDLGDILQIFFDIRHLTTLLALAPRPPSTLPELFGFALSLVGGWKHGAEHPIKTVIESSIRSVSINLVPNAADITDALTDAYGSTDAHHKDCEDSHLITLSSSAVCYGKNKRIDCAPYISTLWSDAYSYLPHKHADLYLSWAVYSPWNFWHLLENLYNEFCNIFCQDWGCHSCMQASKCKRGKHGHERSSCSCSSIVSCKGVSPTLYRFGFRLGDAAKLNSSNAKKVCYNFQKQFSRVIKSKYFTVLFNKCDDLLFQIRAPFIWLNVALWLLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAGRVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBX7</accession>
    <name>A0A061DBX7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Regulator of chromosome condensation (RCC1) domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0302980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768580.1">
        <property type="nucleotide sequence ID" value="XM_012913126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBX7"/>
    <dbReference type="STRING" id="5866.A0A061DBX7"/>
    <dbReference type="GeneID" id="24564935"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302980"/>
    <dbReference type="OMA" id="RPAKLTY"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="145"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="358"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="411"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="463"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="519" mass="56079" checksum="B568434BF087F0ED" modified="2014-09-03" version="1">MAGWVCDVCLVPNDEDVAACCCCTTPRPTGAPSAPSNGGTSTTVQVSESVDNSQPETKDVNKDVKRIRYSFPSSELPLSCIMVVGSSEVDQLPRSICDSGLERGSKNKVSLYECSLPTPVTEGIRGWVSSVACGSLHTAVVSRTGEVFTFGCNDLGALGRSENDTDKDSLAECNPCPVRLRHTVSRVSCGDNHTLFLTTSGAVFFTGAFRDTQGNIGIADYDELEKLTNAEHFKTPVMLPFISHGDNPIKDICSGENHCLLLPTDGSGIYVFGSNEFGQLMLPSGYAITTPTEEKPDLSSEETMKLALTWPQFLNVDDLGLMKRRPGGEAKRRKHGDEFVSRIFTGYCTSFFETGVSRRIYGSGRNAQGELGTGGDELQLSHPTELVGLRGLRISKIVGGQFFTVALTTGGNLYSWGNRSYTGTGSDDDYATQRTPAKIQFFKDNVRNVFVGADATFAVVSHGKVYAWGSGQNYVLGNGKDCLFQKTPELVPKKHFRGHKVVGGMGGSQHTVFLCRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY6</accession>
    <name>A0A061DBY6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0313990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769683.1">
        <property type="nucleotide sequence ID" value="XM_012914229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBY6"/>
    <dbReference type="STRING" id="5866.A0A061DBY6"/>
    <dbReference type="GeneID" id="24566038"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313990"/>
    <dbReference type="OMA" id="IHPAFHF"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="109" mass="11250" checksum="68D3922AFC3622F8" modified="2014-09-03" version="1">MALVSTLVTTLVMALVTTLVMALVITLVTTLVMALVNTLVMALVSTLVTTLVSTLVSTLVSTLVTTLVMALVNTLGSILVTTLVMTLVNTLVTTLGSILVMALVSTLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC22</accession>
    <name>A0A061DC22_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0303680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768650.1">
        <property type="nucleotide sequence ID" value="XM_012913196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC22"/>
    <dbReference type="STRING" id="5866.A0A061DC22"/>
    <dbReference type="GeneID" id="24565005"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303680"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="304"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="393" mass="44365" checksum="C95E8A32389674E3" modified="2014-09-03" version="1">MAPKDKAAQPEPRVLLGRPKNNLKMGLVGLPNVGKSTTFNLLSKQMVPAENFPFCTINPHEAVINVPDERFKHLCKVFEPKKEIAACLSIFDIAGLVRGAHKGEGLGNAFLSHIDAVDGIYHVVRGFEDDEIVHTDGEVNPINDLETINQELILKDLDKCTKALVEIDKVYQRNMKVKAKKEEFDTMTKAKEVLEKNQWISHANWKASEVPILNEYNFLTAKPVVYLVNLSEKDFVRQKNKWLAKIAKWVAENNPGPIVPYSAQFEQALEAFDTDEARAAYLQDKNGATSRIDKIISSGYSCLNLIHYFTCGPDEVRCWTIRNGTKAPQAAGVIHTDFERGFICAETYNYKDILEFGSENEVKANGRYLQKGKDYVVQDGDIMFFKFNVTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCA5</accession>
    <name>A0A061DCA5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0401780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769873.1">
        <property type="nucleotide sequence ID" value="XM_012914419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCA5"/>
    <dbReference type="STRING" id="5866.A0A061DCA5"/>
    <dbReference type="GeneID" id="24566228"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401780"/>
    <dbReference type="OMA" id="RRGGHEW"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="601" mass="70873" checksum="7EA48D008C214A75" modified="2014-09-03" version="1">MTGGAKDSLVRENDRQWTLSNRVEAEGLEWLYADPSAAKQKEGNLEEYLLGKSIEGARGELARDPIDHAAAGSLLADTAEGQPLDDTLNKFREDPLFIIKKIELHQRQVMKKYESLVKTGVKPTTEPATDTYATERPRERHDRRRVYDIDRSGGRDYSTSPRRRDRSRGRMHRASRSHRRERGIQRSESLRRRPRGSSRSRDYETSRRKRDRSRSPSGDYRHRRRDNRHRSGRRSSSIGDSERSKERCRTRASRHSYDSRSSGSRVLSRSSSSRHSGRYRRGAERRRYDSRHRQLSRSRVRRHSRNTGMDSARQSRSYDRHRRRSRSPSDDTYRRKQRIADERRPRDGRTDYSPARRSPSYGRRHHTSSRRNHSSAYSRSSKSADSDRRGHRRERRDYTERRRTRLGQSDSAGSASYHEERDRRRERDADRDRRGRSRSRGRGNDYGGRKEEGLQSSKDERQETQSKEPMKAKCGPVLPRKGDTLRYAFGVTEDIMPPQAIQDRAEQRRREMEERKRLQRDTYAPQNHEERLTEMQSHGMSHLKERMEKMAEHERNVQSEEVDAKGAKGDYISLMKQHAFESAKKEERIRQRASRSLVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC1</accession>
    <name>A0A061DCC1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769898.1">
        <property type="nucleotide sequence ID" value="XM_012914444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC1"/>
    <dbReference type="GeneID" id="24566253"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402035"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402035"/>
    <dbReference type="OMA" id="ISMSTTC"/>
    <dbReference type="OrthoDB" id="409650at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="110" mass="12617" checksum="D0E24B5A55663404" modified="2014-09-03" version="1">MKKVSTLRVFLVIDAIIILLLYFNADKYCDVPLSILPSSLGVHHVRKHFGYKSSLITEIVLLTASFLWMAVGTINISMSTTCQSTNPYVWWTVFVFVTFFWYGTQNVRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE5</accession>
    <name>A0A061DCE5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0305680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768850.1">
        <property type="nucleotide sequence ID" value="XM_012913396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE5"/>
    <dbReference type="STRING" id="5866.A0A061DCE5"/>
    <dbReference type="GeneID" id="24565205"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305680"/>
    <dbReference type="OMA" id="NESHTRM"/>
    <dbReference type="OrthoDB" id="337625at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="232"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="573"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1076" mass="119047" checksum="B30BC3DBC3BA8BAB" modified="2014-09-03" version="1">MGPPYSAAGAEEGDFASLGIDERIRNPMEKRGITRPSRQQHAAIQAMLNRENVVLQSKSGTGKTLSFCIALVQMMQQRCCAEKKGAATGDADELQDAQTGREHEAESDVKSETKAIPAKGEIEFSPEGEDKTTAVDPLEGTLPTTSRVEEGDPAVGEQEDGAIAKTNGQRENEGEANAGNRPDVEAGQTENKNVGATHTDADIPPAETDTTQRMEDASETQENNTMEEVTFGNAVVIAPTRELAVQINRTLTELAEEIPDVKTALTVGGADMKKDVGGFMNMAPQILVATPGRLINVIKFVKRLAKASATHSKVLYWDTHIVVLDEADMLIDDHFMDQTRRICKRLVNPFVQVVATSATFVKYQFKLYEDLLNDLDEDFYKRLLPTLSKIGKGDFDILKSAFSYHVYSALKKLVEKGDFTSFGATDEQYKEANELEERYYDVEFVEMEDSCDSDVAVQTHDNGEPTSDHPNESKYRLHHTLKSIVDFLKEFMRETKQMIVSASHVNRVELPAKGVICFTENDCLQDVQSVKEAIEEGEQDVVDKFDSPVLKNVVFCYTKVPEAPNIVKQVSLKLHVAIEVLKQAQYRKCIIFSNESHTRMLTANTLERLGLSCTVSSSRQSTDTRQQVVENAEKNDRNVVIAADLMSRGIHIDDVDLIINMDLPSSKEAFLHRSGRTGRFGKPGICVCICSDPEMDTLRYLEYSLNFECSHIEDVLHVDKGDEASPEKREDEADPQQIANPTANVVSGIAKAAETGGSVQSKCSPRQKPTSVSTKNAPGVSSKHEVTADNKEFYTPHQRIEDTLRDTLVASIHSKVFPGLMEYVIPAFSILAKHDVYLEGAELASARSEDHGHLSGPTSENAFRIKFVEYHTARVILHVSSDLYQAIAACDKGEEFSESLYHIIAIQENGSAISILDPVHRIFRTVEGPLLITVVGCRDALELISGLLTMLNVEFVVHETRRKDKHVVSFSYIASNLSNCRGNAATTAGRAMIVDLFRERFAEECSQDMLLCTDVMVTHFIRETGASFPAAFTLAYQAVTQELYATGADMGTDGATNRRARNLILRHPFDVHAHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCF6</accession>
    <name>A0A061DCF6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769953.1">
        <property type="nucleotide sequence ID" value="XM_012914499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCF6"/>
    <dbReference type="GeneID" id="24566308"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402550"/>
    <dbReference type="OMA" id="YLVKITH"/>
    <dbReference type="OrthoDB" id="10349181at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="261" mass="28847" checksum="305A2C0419BE52E2" modified="2014-09-03" version="1">MVHKSLTDLPRNLKEGIDWLLAVKGDDGESNLKALGAAVYDFLAQQPLALTNVPSLENIKLISMGFMWNKELRDLWPANVMLGKFIHSADKKADELADTMGTRPEKVAANIGTIVHGVEKFLDDIKHPAQYKSAYGHKATWDRSCAKNPEDCAAIFVGIAPMLYVGLESLRDASESASGAFLSDEISTRRFRRVFKAMGYRKRRLRPNIGGPDFLKALSNVQKDVLSILDDVSGFDDPDSALDGKSKADSILNDFGSWPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ5</accession>
    <name>A0A061DCQ5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0307230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769005.1">
        <property type="nucleotide sequence ID" value="XM_012913551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCQ5"/>
    <dbReference type="STRING" id="5866.A0A061DCQ5"/>
    <dbReference type="GeneID" id="24565360"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307230"/>
    <dbReference type="OMA" id="KFIEWQF"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="175"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="847"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125123" checksum="0209125031B0811E" modified="2014-09-03" version="1">MSKRAQLLENEALVRALWQEGRVFDASVPASGTADKYFCTFPYPYMNGRLHIGHAFSMSKAEFQARFQRTQGKAVLWPFGLHCTGMPIMACADKIKAELAEAKNAGLSAPITGSEELPVDTAGSQEQAQEKDCTKFSSKKSKLTAKSNVKMTQMEIMRHMGIADAEIPKFADPQHWLTYFSPLAIQDLQQFGTSVDWRRTFITTDRNPYYNAFVEWQFTRMKDLGTLHFGCRASIFSRSVMQPCADHDRAEGEGATAQEYTAIKMHLEESPFSILDSLDAPYAPYKEVLASKQVYLLAATLRPETMYGQTNCFVLPEGSYEVVLGFSTPKLNFNDFGVVESIVSVEEAVKRCDCLYVTSARSAMNMAYQGLVLLRPPQAPSTLSEVHSVSRCNGQELIGSALRTPLSVHQRIYVLPMLTISMEKGTGIVSCVPSDSPDDYMTLSEIRKKGAYYKEKYNVDAVHCSLDAVPVIDIPGLGSCAAELVCQQEKVASSKDSVKLERCKEILYKRGFYEGVMAVGPYTGRKVSEVKEVIRDEMLRDEQAFVYYEPTKRVVARAGDVCIVALCNQWYTKFSDEAWKQRVLAHVGDPSKFTCYSESALNQVKHVVSWLDNWACSRSYGLGTVLPWEDISQNKNSLIESLSDSTIYMAYYTIAHYLQGDIFGTTPGSLGLKAEQLTPEVFDYIFHLSDKAPADVDAAMCEKLRQMRDEFAYWYPVDLRTSGKDLIFNHLTMSLFVHNAIWGNVSSIDAMPRSYLCVGHILVDAEKMSKSKGNFLTLEDAIAQYTADGTRVALADAGDGLDDANFAKETAEAAVLKLHAILLSAQSDMELAGRANSGSSLSEYAKRVFMNELCVLAERAKESYSNFVYRDALKYCFYDYINARRNYMQMSQGDVDHAALVMYHETFCRIANPIIPHMCEFIWLKVLGRSTSLVGEPWPTLPAIDWALHRQVKLLSKNLDDFRKCKEKSLATSKKRKGAAPVAEFTGAVIYVAKEYPALHQEVLRALQAMDVVSGAMTEKDVIKALSTSDLVSKASVADKKTMLAFASFQLRDVAVMGSSALLLELPYCELAFLRSILPFVQQSLEVTELHVLPHDEAHERDTTSIRQSAFPGRPAVFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCS9</accession>
    <name>A0A061DCS9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767931.1">
        <property type="nucleotide sequence ID" value="XM_012912477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCS9"/>
    <dbReference type="GeneID" id="24564286"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208990"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="8096" checksum="50D7410454DFF5BC" modified="2014-09-03" version="1">MLSWMRSTSDTEWRGASSPMESCVKQCRAVERVVFSPSIHHKSNVREADGGCTAHGLRIRLHDCADRKVLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCX8</accession>
    <name>A0A061DCX8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U2 small nuclear ribonucleoprotein B', putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0308670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769150.1">
        <property type="nucleotide sequence ID" value="XM_012913696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCX8"/>
    <dbReference type="STRING" id="5866.A0A061DCX8"/>
    <dbReference type="GeneID" id="24565505"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308670"/>
    <dbReference type="OMA" id="VRMIPTK"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="23628" checksum="2D21260AD890ADEE" modified="2014-09-03" version="1">MMPEQAYHAADTLPNQTLYVSNLDDQVHVNDIIKLLFELFIPYGEIVDIRARRTQKLRGQAFVSFSEISSATAALKGVNNRIFLNRPIKVAYARTQSHRSMKPSECYRLLTSERHRPSDPAPTQDAAEGAQDSSGSHTLFVENMHPEMNKMAVEILFKQYPGYKDCRFVEGKCVAFVDFATEYQGEVALQGLQGFKVSHGHELRISFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCZ1</accession>
    <name>A0A061DCZ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769170.1">
        <property type="nucleotide sequence ID" value="XM_012913716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCZ1"/>
    <dbReference type="GeneID" id="24565525"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308870"/>
    <dbReference type="OMA" id="PSCGCNG"/>
    <dbReference type="OrthoDB" id="366863at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="373" mass="41043" checksum="116E39283644213E" modified="2014-09-03" version="1">MEGRMAAAKEMCCGCDQPCFVVQRKSCCPKGCKRCEIKKCKEKQECQCNDCNCGCKSAIKEGKQCKDSGCPLCIVVCKTVEQGGKCICSICTCGCENAFMQNKPCYEITRDKCKNCQIRCTKLKPGEDCMCYLCNCGCNGVNCQCCRWCNPDTTCGKNGDCNSEEIHGTNCPKGKCKQSPGSCSEVTCMCKEMGMVEREGLCECKCKCEKQCPRILCAKAKKDGTSRLCSKHSNGGCGCECKCNCNAFGKYYCKDHEAGGKGCNISECNIIFYGIGQCRFPCTNCGRLCDQDRCMIWIRVIVIGLIIVASLFVMRAIFPEKFHAIMAKIRASFPITSVHSGRSLNNLVGDRIPVEVGIDRYPAFRARTYTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCZ7</accession>
    <name>A0A061DCZ7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome c, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0308970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769180.1">
        <property type="nucleotide sequence ID" value="XM_012913726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCZ7"/>
    <dbReference type="STRING" id="5866.A0A061DCZ7"/>
    <dbReference type="GeneID" id="24565535"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308970"/>
    <dbReference type="OMA" id="KARCAQC"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="115" mass="12488" checksum="D7BCF40CBCE3A5D7" modified="2014-09-03" version="1">MAKPEPDVQVPAGDAKKGAKLFKSKCAQCHTTNKGGATKQGPNLFGLFGRPSGSADYAYTDANKSSGIVWSEKHLFMYLVNPKEYIPGTKMVFAGMKKEQERADLIAYLKEATGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB6</accession>
    <name>A0A061DDB6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hydrolase, NUDIX family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0311570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769440.1">
        <property type="nucleotide sequence ID" value="XM_012913986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDB6"/>
    <dbReference type="STRING" id="5866.A0A061DDB6"/>
    <dbReference type="GeneID" id="24565795"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311570"/>
    <dbReference type="OMA" id="WWYCDKW"/>
    <dbReference type="OrthoDB" id="365787at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="230"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="488" mass="55030" checksum="6105B7548A82E674" modified="2014-09-03" version="1">MSSEALCKSLKLALRINSSGGSAAGSREDAASHRRPEPCPSVFVPGPPVGMAAFPMAMPPPVAMRSRDPRAVYPCPSSITPSPLPRCPSPKHLPSEGHTSVMAPSAAACVGNAPLRERDPSISEQRALLLTKHGNVDADLLDQALSDCYGRFVALLPEEVLSDHVRLCFYLREAYWWYCDKWVVRHPKKLCPMKFGAFLTLVCDDCPLLRAFISDEEEKVLLDNWSKYNQKIPLRGCMVMNKTCDKVLMVQSYNSHNWTFPRGKTDEAEDDSACAAREVLEEVGLDVRQLIHPEVFVEHVSNGRTLKLFFVPGVDEDTKLGSNTEYEIGEIKWIPLSTLVEAQKKQMKHFRLFDVTQFVKGLWEFVRDFRGGELREHFPTAYANFCRVRDSAEELPSLDEHSLDNPCSTSAGEHRAQLSKFQFDDQHKVDLCYETFGEASGWSADEMFRVNQEKFGVQSTYRQPNAAAKYRSPPRRKLIPFDPESFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI7</accession>
    <name>A0A061DDI7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IPLA2-RELATED domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769640.1">
        <property type="nucleotide sequence ID" value="XM_012914186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI7"/>
    <dbReference type="STRING" id="5866.A0A061DDI7"/>
    <dbReference type="GeneID" id="24565995"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313560"/>
    <dbReference type="OMA" id="YISFENW"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF7">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="884" mass="99935" checksum="FE4D8158F1EF88BE" modified="2014-09-03" version="1">MSLEEAPMSAKFRRGLRNYNGTSLLGLSSNEWSAVRAVNKDVEEALVGVFKRLSLSEGGDAAGRPSIAFMESSQWHHRLPRLFLKTFNRVQNRSAIASHFNADRVISYLSSQGINVERFEESTLDLDGRLHQYIDLLLHVCYRAKAMASEVITTRTSVAEGEESKDEPDEDRDADETASFDAYQCPFKIGLVTAESRRDYVSTNAPSMSMLFLSLASSVNKALKRISSTGNIDMSAVEDRCMHLDLFVGRKGAGVGYVHDMLMDYASWGYLKLRPNEEPPRDATLTEMFEHVTYVSIDKIGTVGKSVADIGFSFAPCGFLVPYLMGTLSFLSEMNILNATTPLTGGSAGAITVVAASTVRPDVVELMLITEQMCEEGRIKGPLHNLDKLVKSSLDRWLIPGMYRVANERIGELRVSMAPRKGLRYYGKVVSQFNDNEDMRDAVRVSSNIPGLSSKEPVYFRGEVCYDGFFACERKDYCCCPTGAKRTVRINPFIMGRMNLNRQLLCNDYINPFLEGKDVYVVHYLRLKCLMRLLWRRKIDYEKKGNVGEWRNEVESMINAYDMLKGDLPVGHQLWPKIKHFFQRAIKSKSDEEDMSSIAWSTECVRIFKPELAELFMLVVASEIGLGVDTESKLSARNFPGKIDGVDLMARYGLKRGVLMLARTRFVATPYCLLDWLRHELEATARFPSDLPPPTPSDPELELLKDIRHSLMPPMSLLYYYTEFPYLLPSSLNNLQCVNVALKSAVTADIRYLFDVGRCDAFRWLIFEYISFENWLHLRIRQLEKAAAPKRSSVDGTQEVNTAASKPESDAKPIHERQRKMLSDFVEFIDLASIKAAEGEEAGATQADAHLNTLQNRLFRQAMLLDVIPPNYSHFAGHSHLWWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK5</accession>
    <name>A0A061DDK5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0314060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769690.1">
        <property type="nucleotide sequence ID" value="XM_012914236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566045"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0314060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0314060"/>
    <dbReference type="OrthoDB" id="365890at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1482"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1544" mass="172683" checksum="B809B083F6D16D29" modified="2014-09-03" version="1">MTSINHNNNLCLVTLHFPSSTACHCPDHVPPRELYKKFGKILNPKNTSNNNPTNILNNLCSGLETFLGFNSESKGYDGSGIVYSDLDRLCDGVMGFLFSIITDVNKNENLEKYNNNLPGILKKIKLAQYNRKEHFDSSIVAVSRGIREWVSGVEDRHRKVVEPLNELQELLSKHVSLKMEYKPIKEQLQNWQTFAGDYLDKALMSVELLDGVDTKLRNTISSKIDFVKQLVDNFWNSVNDARLWNSVENLGSEFDKKHAEVKTYIQTQIQRVQSALNQKFELIRLKLGSLTHQRTMYLKKIEEAVQNAQKLADDLLSSEINGYDRGCKEKLLLLFIQISDCINRFVDITDSTPLIKQFSVVRDKVSGINAAVQGDLQQLKKEVNELAADVQGNKDSALVKDALKDLEDARKTLDLTTAEITSESKALKKQYEVGVKNIFDKLPISFAGLKNAIYGEGGSSSDPAESSLAKFITDLIAAIGDEDNGNLVRAVNTFHNDATQRIKDAANTAIEEAVKKFKMSSNRINEIDVAQVMTMYNTAAETLEEAVNLISGELSALKGIPTVIEQNREAADAYMTQLKTKIEGIQAAVKAILPKVTTANEALQSSIDAAVQFHQDAQDTANGALAVLHTNLQKYVQNALNDLEEQTQTLYSEQKRVDLTSLNKSVTAQILEIIGLIDSDFHTGLKGLMNKLHGTFTIHNLQKVSDSSLEIFSNKAKEFVTKFFTSLQSQSDLSPDRLTPLTQALSSLLSTMHSQRHFDAAVSRKLADLQAQLTTLAPSSFAEASPLLNVLKAGVQAFHGELAKQYVSRYSGQIYADQLVKPKTSSEAKTVKTMPNPADNTEITEYGRKCAKVFLTALSITHNALKALKKYGSVRWRSQQVNDTTEFGKFFINHGYHVATGDKQQWELQDKVTKTGFHIYKLVVKDDDEHVYTKHDHDQDNGPLKRLHGCLQTYYRVGHVTSASAKKRPSNIFEILCWISGLPSNNVYDDLLHDAVSDLFVDPAKQVTVGDLAAAVVGDEPVPAYPHSIELERTQAAVTRLCSKSYDVLATILGYGDAYTMYAVDFGNNALNFHYPPKAGDCLQMLIDMLRRLLPPLRFLHSQCKLGAEFHGWSECFYGKDVRTTKWTCTDHSSDEVTCQPNCQPKGKANCQPTSPLQSYLSDCLVGRLPHELSSIGCKYDCRTCSKSQPGQPCLTPLGFRAFSGSAKTGKHICDVLDEFFNNEKLLALFTFSPQPPASLPEHFGFALSLAAGLNASNANKHDGVITLQDALETSVKETSMDLYNEASAFITAFRNAYHSTHGGKAMMHPTATNADLKSLSMRDSCMVAAKDNVHCGPYLSSLYSDAYYYLAPKHCNLYLSWAVYLPWTLYRYLQGLFDSFCNISCQDWGCRGCLQNEKCKKGKHGEDYNCKCRGIVECRGVMSVFHTYGFSFGDASKLMSTDEWRYCRNFHAQFKNVLKSKYFQTLFDKCDEFIFKIRSPFIWLNVALWSLSLLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKFNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDM2</accession>
    <name>A0A061DDM2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769725.1">
        <property type="nucleotide sequence ID" value="XM_012914271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDM2"/>
    <dbReference type="STRING" id="5866.A0A061DDM2"/>
    <dbReference type="GeneID" id="24566080"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400310"/>
    <dbReference type="OMA" id="GNIFIDW"/>
    <dbReference type="OrthoDB" id="360862at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="197"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="322" mass="36670" checksum="6CBA3506AF1EC6D9" modified="2014-09-03" version="1">MHQTSDQLYIDVLCLFISPLFSDPEEALRLKLIQWLVRRYISASESDKIGVYITGYRQLTTRHFQLLSRTIEEVCALLDIPPFSIKVNYITDHNSHTHLRDDVCNGIDALRGSKIADNDEPSKPVLVEKHCALDIQLNELLTPLLFYRDYYSAYSLTTVELILLSGTNSGKEFIRWFTDFQRSSADYGCYGAREKWELHIIRIEDALSPFFGESERRLVRQFEAATSNINESSTCICIEGVHHFQQNKEDLSELDRRILATLLLLLDSVSKSDSILLQPRVSSSGASRKRGSLIVVATSDCRADQLSDALTRPGRLDRVIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP9</accession>
    <name>A0A061DDP9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0400910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769785.1">
        <property type="nucleotide sequence ID" value="XM_012914331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP9"/>
    <dbReference type="STRING" id="5866.A0A061DDP9"/>
    <dbReference type="GeneID" id="24566140"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400910"/>
    <dbReference type="OMA" id="HRYISIL"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000010">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="250"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="466" mass="52439" checksum="589E638B77451A2F" modified="2014-09-03" version="1">MPKEIITLQVGQCGNQIGIEFWKQLCAEHGIDQDGRLIGNAKDHQDRKDVFFYQADDEHYIPRAVLFDLEPRVVHGIMTSEYRGLYNPENVFLSKDGGGAGNNWARGYASADRVQEDLFDIIDREADGSDSLEGFVLCHSISGGTGSGMGSYMLEMLNERYPKRLIQTYSVFPHLTTETSDVVVQPYNSILTLKRLALNADSVVVLDNAALNRILVEKLKVTTPSIQETNSLVSNVMAASTATLRYPGPINNSLLGLVASLIAVPRCHFLVTSYTPLTLEKHVSTVQKTTVLDVIRRLFQTQNIMVNEATTRTIHRLQMSAPMKDGLYISALNVIMGDVDPSEIQKSLQRVRERKLVEFIKWNPASIQVALSKQSPFVPQQHKVCGLLLANHTSIAGLFQRCIQQFDKLYSRRAFLDNYKKEAMFSSPDGHGNFEEMEHSRDITQLLIDEYKRAEQDDYFDLGCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS7</accession>
    <name>A0A061DDS7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768721.1">
        <property type="nucleotide sequence ID" value="XM_012913267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS7"/>
    <dbReference type="GeneID" id="24565076"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304385"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304385"/>
    <dbReference type="OMA" id="NMNIELM"/>
    <dbReference type="OrthoDB" id="365861at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="743" mass="81967" checksum="55345A75BDA113E7" modified="2014-09-03" version="1">MSDGHVTFRCELVSDFPMALYGVKVTLWYNDYLSKEKYQRYYSRCKEERDIVERQTVEALDTGKSELFEELATAVHEASEAIENFEQEAQKLALSTRSGATESTQQETWAADTWAAFPEQDEGEVEDLATHHANKIADRPDAAASAGWPSKPTTQPDKLVSSVMSHQRNASFEGSLSLRESKPKANISSDHAGNRVDIDHWGATQPAHRAIKNEHTAGGYVGDDYDLCNYETTGSSYRDYFDGKHIGSYVPGFGKEAYGTEEPCVYKEEPTAGATEHRRVDKKHGIRSQYTADGLDGENGTEGTSRQRVPDAADKEFTQMAYGTNRRRTSIHEHFEDSYNITHESQRAPAPSHHESPYATYCDLLERCIAISDGYDLARQLKQLTLSDKIALCRSILEGGDKAATKADVPPPQKIKSATKPLHVDVTSMITRAAEDERGRDWEVPEPLWRVQDDGGISSYLGNYIVNGGHLFEGIHFTAYLSMRPFRDSTQVEVSTEVVRKLQNMDIYTALRGPGADAVRIVARSATTLTFICEPETWTHTLPSLAVSIVESDGTNREVLVKLPIGPFSFFEPADIPAKKIERIIENNAKVGFYTIHKAFVSRTKLHMHDLLAAMEKYFAITKTNTRQTLAAVDLNGQVLVATLRNRGDAVLLDVWSPNVKTLDSACTYIKEIAAALGADTDPKLALRSLRTMSVFPLEFEQITRSNPSSARSRPAAGGGGSRTGGVARPNIPGAFSGGAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDX2</accession>
    <name>A0A061DDX2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0305580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768841.1">
        <property type="nucleotide sequence ID" value="XM_012913387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDX2"/>
    <dbReference type="STRING" id="5866.A0A061DDX2"/>
    <dbReference type="GeneID" id="24565196"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305580"/>
    <dbReference type="OMA" id="IGIYPMW"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="350" mass="39458" checksum="0E670224DD19A709" modified="2014-09-03" version="1">MGSRFLPAGAFAQVFRRCFAAEAVATAPKLRTFCKPYASRWVKRLDRMQQKKRFALTKDAALQIPESESYTETQVESLGIRPSFPIWSSRRCGVLAYKLGCMSLWDDWGERHMVTVCHVDRCVVLEKRTISDHGYEAVQLGLGYRNPNRQSKQNIGRFIKAGVGSKDKIAEFKCSSDCLLPVGHYMSVRHFTPGQWVFVSGWSRAKGFKGAMRRWHFGGQNASHGTECKAHSAPGSIAQGKSAHIVWRGTKMGGHHGPDPRVTNCRVFRIESHRNLIFLKGAVPGDVGSVLKIRDALGISARKNRGLHIHYPTFVPKPGHSYPVTLQEVPKERDPFLFTEDPMYDHHQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DED4</accession>
    <name>A0A061DED4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BBBOND_0309880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769271.1">
        <property type="nucleotide sequence ID" value="XM_012913817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DED4"/>
    <dbReference type="STRING" id="5866.A0A061DED4"/>
    <dbReference type="GeneID" id="24565626"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309880"/>
    <dbReference type="OMA" id="WVPRSVN"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR97085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="440" mass="49314" checksum="7283B1769ABC1E68" modified="2014-09-03" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGTYHGDSDLQLERVDVFYNEATGGRYVPRAILMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQITHSLGGGTGSGMGTLLISKIREEYPDRIMETFSVFPSPKVSDTVVEPYNATLSVHQLVENADEVQVIDNEALYDICFRTLKLTTPTYGDLNHLVSAAMSGVTCSLRFPGQLNSDLRKLAVNLIPFPRLHFFMIGFAPLTSRGSQQYRALSVAELTQQMFDAKNMMCASDPRRGRYLTACAMFRGRMSTKEVDEQMSMVQNKNSSYFVEWIPHNTKSSVCDIPPKGLKMAVTFVGNSTAIQDMFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATIEDDEDIGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEP4</accession>
    <name>A0A061DEP4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0401270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769821.1">
        <property type="nucleotide sequence ID" value="XM_012914367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEP4"/>
    <dbReference type="GeneID" id="24566176"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401270"/>
    <dbReference type="OrthoDB" id="10675672at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="424" mass="47316" checksum="A49765DE0F737D68" modified="2014-09-03" version="1">MAVSAAENEQNYQAVSDSTGCNSHAKHNEDENYDEDENYDEDENYEDGNYDEDGNEGMLMDISEMKATLKDMREMMASLKDNREMKEIAETMKSLVDLLQRGALHKDVVVPCELKTPHSDGGTATSPSGGGQQQLCSAPPQSQDASSQAQSLNIPETCVVKKSPNLTAHQRVVYNSLTNVPRNFKEAVDWLIAVRGDDAERNLATLGAAIYDLYVHMSGRSTEWSNLDKAIRFSIDFLEQEKLNKHVFVNMILFLLDQRLLVTPNILTTTVVSEDDTENEKYLQTKGLTADTIAEKLCYVVDACAKFLGRIKNRSHYKSAYSPQATWDASFSAHPENGAVIFVGMAPMLVASLLSLKSASSAPKSRFQSLIAYKRMQELIEALGYVEPQRRTGMTASYVGRALGGFRYETIYFIFNLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYZ3</accession>
    <name>A0A061CYZ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger C-x8-C-x5-C-x3-H type domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0101650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766022.1">
        <property type="nucleotide sequence ID" value="XM_012910568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYZ3"/>
    <dbReference type="STRING" id="5866.A0A061CYZ3"/>
    <dbReference type="GeneID" id="24562377"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101650"/>
    <dbReference type="OMA" id="CHHWKNG"/>
    <dbReference type="OrthoDB" id="365571at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR93836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="381" mass="42332" checksum="B734D2E99326767D" modified="2014-09-03" version="1">MDGGVPTDPTPYNDYYDDDLTPLGLPVTLNDLLDELSPPPSAHSKPPSSKNDEHYSSLRHYVEGLSSEEVDETINDVLKNLSLRAGTSPLPPPGNLVGPLQDDATPTLDFSNSDWTSQTGRFSFGENHTALRHPTFNPLEQAYDSRDTFESLSTHWTSYYDDANRSECDFSSGNAAYAATEVGISDMAPPGLSASSSTLYSWPDARSNSCKALTESLRNIQFQVAKVEQALTCAMNETSPAASRQPPPPAKPPMFYKRANDENSMISTQNAALMMGVKLNAPNEFWRTSICKYWQRGVCENTNCNFAHGKKELKATIGVWKTTPCHHWKNGTCRVGRFCRHAHGEAELQPMNMPVHLLRNRVMNALRASDRFQRKRNPTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZF0</accession>
    <name>A0A061CZF0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0103210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766187.1">
        <property type="nucleotide sequence ID" value="XM_012910733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZF0"/>
    <dbReference type="STRING" id="5866.A0A061CZF0"/>
    <dbReference type="GeneID" id="24562542"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103210"/>
    <dbReference type="OMA" id="FYTREIH"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53377" checksum="295C8300E5B4F2CA" modified="2014-09-03" version="1">MKIRWSVRLALYAAVTIFVSAYYDSWSATTTMLVRFGVYRDSCPPSDEGEQAQGPVQCEEQLKRLSGLLSVFRISEFVTSIGTGVYMDLLGPRICIITAIVLRVASWMLLAYMPHYNSLMILACVLCGLTVNAVAFPVYTAARYWPAYQDMAMCIISACLSIGCFYVPVMNLIMSLMPGADLPTFVYVKLLITHLPWLLVSIVIFPNNVARDIASNMTPAMADKNTEMEVKEETPDDSAWNFKTFLRYIVHPEILVLSVVFVLNCVSLTFAQESFTQIYINNPVAENFNGVMLPLSFLFSLMFMWVINRYGVVVVMLGLNVVSMAMHAFLLSSETVTSIFASICISVTFSGFITFFFICLEHIVDIKYSGSMKGYLTTVAGVTLAINPLINYLIATYGGMNGWQTAFIVIRTAMIAPLLWLMRRESIRRRSGAIASHTEGTSSSSMEASGKSCDNANPDSVAEEDILPVSIKLLPGASVPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZI8</accession>
    <name>A0A061CZI8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765984.1">
        <property type="nucleotide sequence ID" value="XM_012910530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZI8"/>
    <dbReference type="GeneID" id="24562339"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101270"/>
    <dbReference type="OrthoDB" id="366520at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28530" checksum="BCA0374334A308B9" modified="2014-09-03" version="1">MELHSLIAAPRNLKEGIDWLVALKGDDAENNFKAMATAVHKFLADKPVGKMELRDLEDVKSVSKEFLMQLEVHHHPYVKDLLTRYNVAMDRNLGFFDRAFKDIAISDYENVLQTQSIEPETIAENLGKVVHSTEKFLDYIKRTRRYNRTYSLQATWASSCTHDPEVCAVVLVGIAPMLYAGLRCLIDAAADAFMEGPASIQEHSLISVLETLGYEGQPKRGKVRSSDIRSALSDVNKDVLNVLYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZX0</accession>
    <name>A0A061CZX0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ser/Thr protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0102860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766149.1">
        <property type="nucleotide sequence ID" value="XM_012910695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZX0"/>
    <dbReference type="STRING" id="5866.A0A061CZX0"/>
    <dbReference type="GeneID" id="24562504"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102860"/>
    <dbReference type="OMA" id="KEVCEIM"/>
    <dbReference type="OrthoDB" id="345735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="52"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR93963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="353" mass="40421" checksum="563091F1BB551BE0" modified="2014-09-03" version="1">MPREHPAQVADGEICLETPRADCRRESTYSAPLLDLAGRSSLHSYGFTIDDFDIGGIVGDGAHGQVFLARERRTGFICVIKCISKALLVQSKQEAIFKREIELHSHLRHPNIVSIYTWFDTESMVCIVLEYCFHGDLYTHLHQHKRLPEQRVAEILFEVTWAIRTCHDKHIAHLDIKPENILLDHNFSCKLADFGLSAHVGNGKGSISHMRGTYDYWSPEQAACKHNNRGKFGDFNHKSDIWALGVLAFELFFGFPPFGSTTQEPVNCVLERVQTHEWYRILVERHGRSRINEASPAFIRFCNMCFEKDAGRRADAATVLEHQWLRSRNAERYHSNMFVNQVRSYAAEYAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZX5</accession>
    <name>A0A061CZX5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766154.1">
        <property type="nucleotide sequence ID" value="XM_012910700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZX5"/>
    <dbReference type="GeneID" id="24562509"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102910"/>
    <dbReference type="OMA" id="HYEGIIR"/>
    <dbReference type="OrthoDB" id="365313at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595820" evidence="1">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="258" mass="28815" checksum="22E7146E1C664B46" modified="2014-09-03" version="1">MLGTACVYTLFALLAAHVAQKTSCEIANAANSAAEVHRTVSGDPKSEKAADPETEIRDIIHDTALKKELSEAGEKVAKSAEVVDESRKSLDNITKEREDISKAIGHAKVDRANELRERKRELLKKIAAIGKTLRLEHDARYPHLAGQPIVLVAKNEDDTKRAASTLAHIEGLRDAINQIRSPCSSLERVRSAAMDTSKQNRHNRFVIVQKTLDSMSAEERLHYDRNMIEHYEGIIREIEDSIAKADEEIAASWQNYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D034</accession>
    <name>A0A061D034_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766219.1">
        <property type="nucleotide sequence ID" value="XM_012910765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562574"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103470"/>
    <dbReference type="OMA" id="TFNECFA"/>
    <dbReference type="OrthoDB" id="364490at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1972" mass="217075" checksum="504D137A92698D22" modified="2014-09-03" version="1">MVLVDSAGRRDPAVRNKKQVARDSLCAVLCDDSSLQKSAALTLARASATESKCRLIPRLCLTGASLEVLLSLVRGELPNCMPSFSISKSLFLPKTRWLDGSGIFPSEDEEVGVNTLRECMQSPEAWERARVIALRALLVHRGADPTALEELLPHVVVGVKPESKKQVTYCRETAVALAVAFAEAIPDGDSFEFAVLQMTLVNEEVKIPILQTVIERAMSEHALLPRVLKLLKRMMNTESATPAFDLVGDAPRSPSLSVFAMAHLCTINAQCLASAVPRALQVIDFHAADCAGLRLMCLLVCAVRLGDIKSVTIRRNYVRFMHSKLAARAYGGYAEDIAEALKSRPNVIRVIVDAIVTTVYTVTRNSQPVYELVAMVSALLELILAAAPAAAEQTPDMKLPAAALDVASLLKVRALVSHLTHCGISIENDQRLDPLLASIAQAVADDGIFAYASRFDFSAQFVIEEAHIWGDIAAMCGEDHGLGLFNAVKARVQSASDIVWTFNTLQRLYVGVAVMRDTELVTDSPDVHGAVVHIREGWCLRDAIKVALATLTLNVSAHAAALAYIAAIAARNNEEALFFVSALVDSTLFLLRNAAVLPWEVAFKMVEMNIVMLARLSRHRLALPIVFSAFRYLFGHQLMQLCRDGVPQFYRFDARWRCLLLCHSDIPAAKVVDSPTTERLQAMTPRDREVYMIVFRSLCKYRPEDALKYVNDLGELFAEYPVMAIDGCTRMCKNDVMDFGIAYRVYVASLMQANFTNTAVVGAVGSFFCEYLKLVSMRIQGQVNDEDVDDLNLIMINLLQLAALNDLHGVTAIAALLKSPLWTKLQTLRNWHINKECGCYSLLDRIKKSQLKCTFSKLDYRFFEFDFTAFIGAEAGEEGSDPASTHGHSLLISAVIDAESEATSRATLLSRRNDAVLGFNREIRRVTREMLRSLGFSKPTISSFRFILESDDMDSRDSMAELGAAACVLPMQGAEIGIANIRLLHLPALFNLYGLIIGKRQFNHEVVCDNAYESVVESGSAMGGKVLGGMALLVNMPNNARSAMLVTHMLLHLKEMGESINATQSDIDPLSCEQTVLYAFALAYMHCQHCVVTEFPLVILELLRSALPKLNVYAALADMLCLVLGYVYRYTNLHFYITEDVLTLFSDYLDATQNHVRIGWVLGLCNLIEDVPRDSIGVIEPLMSRITELVVNGDLPEAKRALLAVPLVQHWALKKCNDIGSAIAKLLVEVCSTTPTDPCIVLLLAYCHYVGFEPHVVDKNCNLAGCDNCPGIGGGNHAEVGGCNDKEGCACDTKVEHAWAGNEGDNQFSCSLTAGSKDSQRQGCAHVLYGENGCHNFDDKRGHYVGTTAFSAGDGSQVPNSIKDGNTAGGDRVPDKLQETLMGSIRLNVAADDVAKDLLIVAAMLLHGFPYMAPPRNSCARRLLRNKNGWSVLFNDLVAALSAIAYQETVEVTMATAPKASRYSRSRGSTTPATQHPVATQMKADEPQWGDESAVVAGILQLTLIKRFLANQAELDCYDEDGSIGNTLAEIRHNPNSFKLLSALTLCKPLKLTLWDIISFEDTECSCERELVLRVYCLHGQINRSLMEHLASAAKYFGCFDRQLKVSFLNCVRLAFWSIDFNSLRLVLSYIADFDDLDVLLTIETLVESCVYLMKGEDGAGLNGEEFASKVLSKLLHPIIVQVVSRSRRHKAAVCLYRKAMPYVNVDQRGELVMTVNSSDIALKSLLCGVCDAAGAPFTFNECFAQLVTQNVSVSNVVLYCYVNVHRHMEVMLHCIHVLNVSTNSEQITLVSLALMALVAERNVASYLLELAFDGKNIEANAKHELRHIATLDVYEFIRLNRQPNLFYYDTIDARTLAKSANVPATAPGTWKNCGLEATPLGRLLPMAKDRHVPNWLPKLGNLALDRRKQSLMPMDLPARKMVSSLSEVGAEHLLLDNAVVIMSAYKAHLIERHPAHPGLRDIIAYLNTRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0G1</accession>
    <name>A0A061D0G1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L31, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0106000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766477.1">
        <property type="nucleotide sequence ID" value="XM_012911023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0G1"/>
    <dbReference type="STRING" id="5866.A0A061D0G1"/>
    <dbReference type="GeneID" id="24562832"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106000"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="118" mass="13811" checksum="C3F07EDC93F40011" modified="2014-09-03" version="1">MAKDKLKKKALQPITRDYTIHLHKMVHRATFKRKAPTAIKKIKEFAAKAMKTTDVRIDNTLNRYIWSNGIRNLPRRVRVRISRKRNDDDDAKEPMFTLVQHVPVDDFTGLQTEVVANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0P8</accession>
    <name>A0A061D0P8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0105320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766409.1">
        <property type="nucleotide sequence ID" value="XM_012910955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0P8"/>
    <dbReference type="STRING" id="5866.A0A061D0P8"/>
    <dbReference type="GeneID" id="24562764"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105320"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF164">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="198" mass="22026" checksum="704A1BDF5F1CF879" modified="2014-09-03" version="1">MVLRVGQPAPNFRCEAVMPDNSFKEVSLSDYAGKKYVSLFFYPLDFTFVCPTEIVAFNDAIAQFEARNVQILACSVDSKFAHLTWRNTPRDKGGIGNVMFPILADLTKSISEQYQVLIPDDGVALRGLFIIDKKGMLQHQQVNNLPIGRSVHEVLRIVDALQFYEKNGEVCPANWKAGDKGMAPTTEGVIAHLTTKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0X0</accession>
    <name>A0A061D0X0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766642.1">
        <property type="nucleotide sequence ID" value="XM_012911188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0X0"/>
    <dbReference type="GeneID" id="24562997"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107540"/>
    <dbReference type="OrthoDB" id="366334at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595333" evidence="2">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="250" mass="27327" checksum="5A1C84CFE4FCC518" modified="2014-09-03" version="1">MASMLAHIFTLAGLLWFTANAQVCLRAALQLNIVLDGQVYQEKAFDDLCSVVDAADSAIVKSSLPFSSISMVPDHWAIYIDGVSLPVADCEQNDVLFQQLGVNDGAYVYLFRNETAYNDPLYAAEYLKRFTKQFGDRIRPVVKRETSSKKSTKPQNKNKKKKSGKMPMDNLSGLIGLLANAVMTGDVMRALGQSVGARNVANREEGDQGHEKGAINNMDVISVRVLALAFSSSANSNGQKRARDESADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Y7</accession>
    <name>A0A061D0Y7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHORT-CHAIN DEHYDROGENASES/REDUCTASE FAMILY MEMBER protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766662.1">
        <property type="nucleotide sequence ID" value="XM_012911208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Y7"/>
    <dbReference type="STRING" id="5866.A0A061D0Y7"/>
    <dbReference type="GeneID" id="24563017"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107740"/>
    <dbReference type="OMA" id="HETLCHE"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="328" mass="36198" checksum="BB778FF414B69CF4" modified="2014-09-03" version="1">MHKGSVIITGCDSGLGLALCSLLPRHGYYVLATCLTEEGAEVATAAINGDLDAAHCQLKVQNGCIECKEGTCFLLDVTSASAVESFCDDVTRRVTATRIPPLYAIVNNAGIWRFGLLQDAFKSPENRLAEVDRWKEVLDTNLLGALRVTLAFANQLHQSTDGCDPRVVFISSVLDRHALPGQGAYVASKFAISGFHETLCHELAGTNIRPVIIRPGALKNTRLFNRDLDRQNAAQTQRLEHDADLLKASYRVLLHFAGDCNQVALTVLDALQTKEPDSEISNVTGALPFMVAEYLPRRLFVQIVRVVLRNLGWLYHRAASIFRRRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D113</accession>
    <name>A0A061D113_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0108090</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766697.1">
        <property type="nucleotide sequence ID" value="XM_012911243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D113"/>
    <dbReference type="STRING" id="5866.A0A061D113"/>
    <dbReference type="GeneID" id="24563052"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108090"/>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="26"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="723"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="833"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="998" mass="110940" checksum="0C072400FBAE3A4C" modified="2014-09-03" version="1">MALGKVCSDSDAPCPIFLDLDGVSDRTLASIRTKLEDSNSAKKIAALEQTILHMLKGEDVSSLLMSIIRFVLPSNDHRLKKLVHLFFQIFDFCTADGTVREESILVCNALRNDLCSPNEYVRGSAMRLVSKLRHWNIVGPMLPAIVDNLKHPDPYVHRNALLCLSKIAERFGTECVLSSTEDTERLLLGNSGASVKAQAFNLLRLCDPSLAVQYLLGVEGTMLSFPARFHLEVLSSFFWLYSLDSRVHSLMMRVTLMLMENSPDNDVRMEGAHIICRMKSTPVEARRAAASALIKVLLDESDLNVKMLVIEKLNTLHARSSSLGDVPNVLEEHVMDLVRALSGSSRHITMGLLSLALRSVTRQNADALLQSFKKAFTTAEDIATYSQRQIAQYRITLIKAIHYTCGLYPERSGIVYDMLLGYLSHRHAETAEDCAMFFKQLTELLPQLREETIVKLLTFIDLIPHSSVLSVCFWVIGEYAGSEQLASHCCNKIYELLSPYPFVVATGSDSAAGSLDRAGTSGSIGLGDGQDDSGVATHTVVLQDGTYGAQLSDKKASTPTATTLRDMLVDTCDPLLYCSVAQCLLKLSFACNDTDCIAKATLVVANLVRLVGRPQYASVYSQRRLRTILKLCLGLLKERDKYRPLVQEYISASCRKWSPAQSSMPLEPKSDVDERISYSVLFGEVGEDEWSIEDESEVGGANPGDNYEIDKLLSTGNSIYKVRTKDADKRNLGAVHQFTSLMDALYIETTLNVITTRLYLTLYLRNTTEVILQNIRVELCANDRLEMSSSIPIITLGPGESRVLQVNFKLKRSLNDVIYGHVYFDKEKSGIQECLPFNPMSVCMYDYVQPSFISPSLFRTYWTEFEWEHKIQIHPSKADPLDLLRGLLQVTHMTVVCPAAPPTLKSAPGPAGQAEFLSKYMEYLKVQPELAALLGDTSFFALNLFCSTPHGEEALANLSVVKQKQGLYSGCFKIRSRTESVALSLGDRVSSLQRTFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D161</accession>
    <name>A0A061D161_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mTERF domain-containing protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0106770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766554.1">
        <property type="nucleotide sequence ID" value="XM_012911100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D161"/>
    <dbReference type="STRING" id="5866.A0A061D161"/>
    <dbReference type="GeneID" id="24562909"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106770"/>
    <dbReference type="OMA" id="WHKFFAK"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF173">
        <property type="entry name" value="EMB|CAB62602.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600500" description="mTERF domain-containing protein 1, mitochondrial" evidence="4">
        <location>
            <begin position="18"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="496"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="90637" checksum="D977116AE19FA9A2" modified="2014-09-03" version="1">MRFGVALFLLSSATALCLQIPGVTGPLQSRGCLARHAEAHTAFVGSGKREYRSHGGECSPSATSDGGRASGVFSRNYRRHADSGCHSHDVSASPYCAYGASDAVYGGRGAPSRQDGCAAHFQSQRPFALRSFFGSVNSVFTDAEYEHRLELNKKYDTITDETDDSGLPLAPENEDYDVDDAVPGCDSDLSMPPSSKEEWYLKRLARGRRFWHKYFADPSQQSLRFYRLVKMKHDLKYCNRVVRRKYIELRPEIKPEVVDGRVQPLTRRQRNQNRSRIQVVRTTVGYDNTSDDSNVLILLTLPQARLVRMVERIRLPHLLALRNYEMLRLLRHSMLFMSKPNIFESTVDFLLTFSRFNPAHEGEIPLFCDLPSKPVKRYRPMIYAVIGKLRQDPFADHLLKVRRSQPPPIREPFPRCESNESSTLTRFLDSCATLVTERLRHAEYDFDAVMDRDFSDNFKEMMPTYTTKESVNRIDYPVTVSFSKEMAAYLREPVESPADGGAAAATNSSSQTIQEAATEEGIEACGASECGTSGEDGEEAMHGRDDDGEAGVAVPPRGSTAAWTRDEVKLMLKRVMKLGLTKPSTLIDRLRRLHCDIGFSFEDLLWLGRTRPQLFRFGNYRQRCQQIYDCDEALTFEDILSMVHRYPNLLTLNVARTVRPKIYYFRRVMRRDVADLRAFPKFLSFSLYDRIVPRHLAVMNAAYRGEFLKVYRFLFESGFYKGYGQTVTDERVPDILPADHARYLAAYEQLSRAPDLRLMFTSSDDAFLRHFNLSYRDLAQGKEDAMKIPLPADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1C0</accession>
    <name>A0A061D1C0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766093.1">
        <property type="nucleotide sequence ID" value="XM_012910639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1C0"/>
    <dbReference type="GeneID" id="24562448"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102360"/>
    <dbReference type="OrthoDB" id="366298at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="249" mass="27880" checksum="8A4B96A14CCD672A" modified="2014-09-03" version="1">MFEHILRFHAGKLLAQGSLACRCAKLLQNGRLKAACERRGFSALSTTPHPEIDRLKALLSHTSHEPSYVYSETVREHIANIRKNLEPSEDTQASDIVQRLAEDADRYHDVLVKYMQNRDRYNQVSLDKPAGGTPAVVTPAARCGKHSNATQAVQTKITNDANIKYGVVGVAFMCVFGSLGFSLHPGCALGGYIYRPVFRQSRLKEETMKTAEQLIRSNRECKQQMRQLHHEIGELVGQLEAHLAKTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1C4</accession>
    <name>A0A061D1C4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0109040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766792.1">
        <property type="nucleotide sequence ID" value="XM_012911338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1C4"/>
    <dbReference type="GeneID" id="24563147"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109040"/>
    <dbReference type="OMA" id="EICECET"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="208"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="327"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="490" mass="55163" checksum="50886E8EB9EEC5C5" modified="2014-09-03" version="1">MEVEGLDSAALKAILMRIDNFEGEFDFLNPAYKCRVVFKGIAFHSVAHGLRFLRLSHNIDGQEYHYDGSDHLPAHVANHVSSMDVSATSEGSDENPLWSAHRHEWLELLLRDKYRRNGDIRTRLGKTGDRQIVFTSTDLFLGFDGKSGQNKVGRITEQIREDMSAYKDHRVWLLMCQNMSAEDFWVTVEESHGDSGICKHRLEGKCLYDIGRIPSCDLKPANPSISRVHASIYMNKRGHVCMVNYNDVTGVTVNGQRLEPHEPFAMRNGDRFTLGASKRVYRISIDRDLVSRKMAEIASKRRELQHKADLHAKRVSNELETFLKGHDEVVVLNVSYKTKRADLYDFFSSCGDVESIQLPQNRGSSDDPASDETLARRGIAFIKFRDKKGAARALERDGMYLNYRKIQVKYKSEDKVMTVQDRAQGVEVAAEVHQGIDAAAPIPAATAGVGALVGLETISGEAVHIPVEVEIQPQDVIWSATLLQCKLCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1M1</accession>
    <name>A0A061D1M1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0108410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766729.1">
        <property type="nucleotide sequence ID" value="XM_012911275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1M1"/>
    <dbReference type="STRING" id="5866.A0A061D1M1"/>
    <dbReference type="GeneID" id="24563084"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108410"/>
    <dbReference type="OMA" id="HWTFVYA"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="195" mass="22159" checksum="AD56DBF4CD5CE2C0" modified="2014-09-03" version="1">MNRQDLRLQKELQDIQSNPEGSVDAHTVDGDIYTWKGYIKGPIQTPYEGGHFMLAIKIPQDYPYSPPKIHFETKIWHPNISSETGAICLDILKNEWSPALTIRTALLSIQALMSAPEPDDPQDAEVASMYRRNYEEFARTAKLWTVNFANNRGDTREGKVDRLLEMGIDRETAIKALADNRWDVTVAINRIIDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1T1</accession>
    <name>A0A061D1T1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766927.1">
        <property type="nucleotide sequence ID" value="XM_012911473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1T1"/>
    <dbReference type="GeneID" id="24563282"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110390"/>
    <dbReference type="OMA" id="NTHEHER"/>
    <dbReference type="OrthoDB" id="365210at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="369" mass="40929" checksum="4B6ED60D395DBD34" modified="2014-09-03" version="1">MNKATLVRCFRGIEDSFSCNEARINPYLFAQKQLKIVTNCAIALTKIDPHEPGAVTHTLLGTFTRHAKRILSETHKLCADSTTSPRLGYKISANQDPHAAAATLRQRILKLQNEASLAFTLAMCAQNTHEHERQCMGGVLPPVEPRLCTDRSVVALIGALHKGERFKSEGSSETAERCFKHLIDRSQSIRRLTCRECSLLLWRRVATHYMNAAATDDCVRQTSTLIYHCYEKLKDEVFMNFGDDPPGTSDPRQDQGPPALPDERALKRLQQTLSNVSQAALIMRHCESPSGAASLLHALGPSSIRRLSHMLTLAWRLQGRAQRSHKSSDTHTKVGLAVADAMDGRRMRCTYESAVGNSAYTVDILVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1U0</accession>
    <name>A0A061D1U0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766794.1">
        <property type="nucleotide sequence ID" value="XM_012911340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1U0"/>
    <dbReference type="GeneID" id="24563149"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109060"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="99" mass="11042" checksum="BAD2002DAC203865" modified="2014-09-03" version="1">MEDMMQLLHCFAKLDFRCSRVISRSTALFWLDHIIALQKQQAILSAKLGTANVRNHGWLIGDSNGGIRNPGKCKDDAFLQMAGMLVAMNFNATSQKKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Z9</accession>
    <name>A0A061D1Z9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BBBOND_0104560</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766333.1">
        <property type="nucleotide sequence ID" value="XM_012910879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Z9"/>
    <dbReference type="STRING" id="5866.A0A061D1Z9"/>
    <dbReference type="GeneID" id="24562688"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104560"/>
    <dbReference type="OMA" id="PLWNNMM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDR94147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1037" mass="113450" checksum="0E7D97EE58ACA255" modified="2014-09-03" version="1">MAGNRAVATEKSGDLVVLRTPHTSSVDDVLKHYRVTLEKGLDSKAVEDRRRLFGANMLEQKAKESIWVLFLGQFDDMLVKILLGAAIVSFVLTLTEVTDSYAITDFIEPLVIVVILVLNAFVGVWQETNAEQALDALKKLQSTVATCLRDGKWVTIDSVDLVVGDIVRMRTGNKVPADLRVCSISSTSLSCEQSQLTGESRNVAKTSKPIPAGMENCEIQEKRNLLFCGTTVSAGSCVGVVVATGMQTEIGAIQAAVLDAGSQERGTPLQRMLSDFSTSLSKFISVICIAVWVINVRNFNDPIHHSFMKGCIYYFKIAIALAVAAIPEGLPAVITTSLALGTRNMAKRNAIVRKLPSVETLGCTTVICSDKTGTITTNKMRAQVLKLVGNDDKVRSVHFTDDGKIDTTKGNSNEIAPGQGLNGPFGKLLSAVFKCGCICSEAAVEQEEGEPTELAILHMVNDVHAFLTPNGSAIVSAEYQKQIRKEATLEFCRDRKMMSVIASEDGGHQLYTKGAPESVIERCNMYMKADGTMSPITPAVKATIMQEVEMMARDALRTLAFACSNDAAGALQIYKQKSASGEISEGSPEFFQEIERDLVFLGLTGILDPPRPQVRQAIEMAHTAGIRVFMITGDNKLTAEAIAKRVGILPPEFPAASDRVCYSYTGKEFEKLSDSEKRRVVSGHGVVFSRTEPKHKQDIVSILKQLGETVAMTGDGVNDAPALKMADIGIAMGITGTEVAKEAADMILVDDNFQSIVAAIEEGRCIYSNMKSFIRYLISSNIGEVASIFLTAAMGIPEGMMPVKLLWVNLVTDGLPATALSFNPPDHKVMLKPPRSNDEKLIDGWTFLRYLIIGLYVGVSTVGSFVWWYVRGISPNDGNTTVTLKQLMSFSKCTQWSDFSVNRLEGMTDDMCSYFTLGKIKPATISLTVLVMIEMFNAYNAVSEESSLFCTPPWLNPHLMVATTISFTIHCIILYTPFLASVFGVVPLDKHDWIAVLMWSFPVIIIDEIIKWVGRNYIRRSQRHEEPTKPMADKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D212</accession>
    <name>A0A061D212_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAJOR FACILITATOR SUPERFAMILY MEMBER protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0109660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766854.1">
        <property type="nucleotide sequence ID" value="XM_012911400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D212"/>
    <dbReference type="GeneID" id="24563209"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109660"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="499" mass="54159" checksum="8A14E3FD03D3CEB9" modified="2014-09-03" version="1">MSETVAEDATTSVLKKVTYTSLGQALYHLVSFFEGYDQQVLSMCMRAFELTLGLSQTQLSTLSTVSTMSRMGCCLIWGLLADWYDSNYVLGGGLLLMGMASIFLSSASHYKVILFLRFLHGFGFACVYPVQQKIVADSTGLEESKKLKETSAPQGSTSSKETQESKDANDIFTRLQALNCIGRLICAVITTLIARKVLLGYYGWRTSYVVLGYVWILFGIAIVCGMQAQRLKSTESFPELISGAFNAVFTSGTAWICIFTIFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAIAVTLIGGAAGSGAGGEIIKALNKVDDNHAEPSSGCAVMIVRYVVCLLFFLGPAPQGKLLWYHYVELAVLGATLVSVGGVDRPVMKNAIQDKYQATASAIIRTISGISSSVILYQIAGYLTEKVFGYVPSRESFESMEVAVKERNAEALRKSMMYIILAGTTLNLVCYLALFCTYKGDKKKVGEQNEEEAAVHTELENGGACGIFGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D250</accession>
    <name>A0A061D250_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0109960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766884.1">
        <property type="nucleotide sequence ID" value="XM_012911430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D250"/>
    <dbReference type="GeneID" id="24563239"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109960"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595894" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="487"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="826"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="955" mass="107593" checksum="F3EFAE4E100331CA" modified="2014-09-03" version="1">MKYLWAICALLLPPVIGDDFWCDFGRPENSLITNAVVICHVHLNDDINASVVCPHEVNDTDYVWHPKPSDDDPTQLNTYVSESDNFRSFPISEVIKSEATKSLIFAVSALSGKTLDIIPIDELVAITEHRLIFICGPRNLVLSDTLQRLLGRLKYTRGIQKVPWTAETPLNQEVKKIGQGLGVFFLYRGREYQPFQGCGTRDSPLFAAGNEVIVDPVTGTRSCVVDPMSESRIGFVCDDVVVPSKCMKLLIDKNGTMGEAPLPHLYSRFKRKSPWVIAKYFSGLALPPIDGECRCMHYVGQKVKAKLIIRTKKEYVCDIASMIMRDQFRHIRGHWCSVVLHPGSTLTIRFPPRFVNSVSADKDSDGSDDEYAPRVPFSTLPYVRDYESEFQPEDLITLRQQTNYYDLETYEEVSYHRALAGDALELDVSQMERGEVTLKYNAGKPLTIRNGHNSFFYHWTMISRNAMNPTKIRAIINVSFAFTHKYDIAGCDRSTPGLFNPEKSAPHCSFRTVGNGIGKTYECSYSEYFNGSSVGINCGSDDILMPSNCDSTMYDLDSNSIVPLPQYFRKTAVSPIRGFQAFLISFTGTRPVSYGCVCVDKHGKETARIVLQFNDKKERTYKVSRNNEPLTLHPYFTLPWSEVGLVSEGFTPPEHLVLHNVSQKSIILDIGTSLYMGCDPDVQVFANYRRIQTAWFPTEHHLFYYSANEMPYGYELVRKKYNESFATTPGALKVVYDDMYDRNGNEKLTVKTSKEGIIISKDITNTQYVPVIFVCGKRPEASDLSDIIGKPSTSKAPSEPIHHASWTSMGYTWNVIKIKVKTTDPYMQGCGVTYESTELFKPETRKLYDANGREVGCKIDLQASGEAAFYCPAPYVLYPPGCFNQVLVDGKVKYLSDISQSLVASRTNHFVTLEFDGSRIGRGETLRMTPPLECQCVTIKGVVLSTIQIKHYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D257</accession>
    <name>A0A061D257_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0111240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767012.1">
        <property type="nucleotide sequence ID" value="XM_012911558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D257"/>
    <dbReference type="STRING" id="5866.A0A061D257"/>
    <dbReference type="GeneID" id="24563367"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111240"/>
    <dbReference type="OrthoDB" id="364658at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54423" checksum="D932C978D6894081" modified="2014-09-03" version="1">MRSSLESLICDARSRRKIEDRPVFLTVLSQPSTAFVDLLFAIFKHGGVAVSVLPVCFSLLRSRLATSDPTCFEKHIVDNWRSMIVEACSDVVVTTRDYYPLLSPVCRELTVPLHVLVRAPSVISASEFDAAMRAGHGYFDLMDTPNTSSEVPEDASQLLGNCEREWSLLHVFSEIGSCNGKVVAHTRATLDAEGERVRNVFSIGANDQVLNCLFPHECGFIMYGVLQPIHVGARAHYPLVVPPVSRYSSLKPQFPLTLRRDLRETVTLSLAQSVFEYVRCSRCSPSVLLCGPEMLRYLLEFISCGELSASERRSYLGHWAGVDRIYVIVDASQLDSGSLIETVTAFLKATSLTASVTQLYTLPEVGVVAHRDLRAPHSTPIAMPGCAIIEHGSNFTITARTGSVFQSYLGRQHATKCAFVNGELRLKFRMPVESTPLLPRHLEYVTYFKRRRERMSRYPQGYIKQVPVRTQFWGNYTGRKRHPSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2E8</accession>
    <name>A0A061D2E8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Programmed cell death protein 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766959.1">
        <property type="nucleotide sequence ID" value="XM_012911505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2E8"/>
    <dbReference type="STRING" id="5866.A0A061D2E8"/>
    <dbReference type="GeneID" id="24563314"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110700"/>
    <dbReference type="OMA" id="TVYVFCC"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="1">
        <location>
            <begin position="246"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="360" mass="40740" checksum="BDE2053CBC515F64" modified="2014-09-03" version="1">MGDSEYESTELFAKVESGKPWEYQRQFFPSKIGGRPAWLEPENLPQEEAFVCPKCAGVMTFVLQLYAPDDEEPSGDAFHRTIYLFACQPCGTHWRALRSQLPRTNAHYASHPQPYGMLFPQPDTIIAQRCCPACGLPSDGEPKPGEQLTFASVVHDFTSYAGWRALHPRCKIATTQQTLEATLPEALLRICEGEILEPENYLAHEKELYRKYQEMKAQRGAGDEEELDESEEKAIEAIQEERLVVDRNFERFCKRTTPNDVVYYCRDGKPMWTSDRAPKLTCATTKDAPEDKEVVPVCSNCGGQRSFEFQVLPQMLVHLGPVRLDFASVAVYTCAASCNLLGQYQEEFVYVEPDLSLAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D336</accession>
    <name>A0A061D336_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0201850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767214.1">
        <property type="nucleotide sequence ID" value="XM_012911760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D336"/>
    <dbReference type="SMR" id="A0A061D336"/>
    <dbReference type="STRING" id="5866.A0A061D336"/>
    <dbReference type="GeneID" id="24563569"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201850"/>
    <dbReference type="OMA" id="HIFAEMA"/>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="136" mass="15396" checksum="C44833BF3C886D33" modified="2014-09-03" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPVTGGIKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3P1</accession>
    <name>A0A061D3P1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LETM1-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0204690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767497.1">
        <property type="nucleotide sequence ID" value="XM_012912043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3P1"/>
    <dbReference type="STRING" id="5866.A0A061D3P1"/>
    <dbReference type="GeneID" id="24563852"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204690"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="8">
        <location>
            <begin position="351"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="849" mass="95077" checksum="FA799521D0516EA4" modified="2014-09-03" version="1">MWKSVIRFDNRAANFQGRRPVLLLHGHCGSVSPSITCVVSRSFSRDAHVRSGVPSGSDSVNSCGPNDGEKISEAAETRCPVTQDRKDAANVEHGQLKRTTWSVSSCGVIQFPRLSPEATHTGRLLDGATDIGKEGFEKSVFAIHPRLVHPVGTYACCDGSGVLDRGDVSSGEQRARPRSGATPIVNHFGSLQGFPISFGMDCNGCMSGFFPSRRSFAFWNRSGNKDKDTPGTPASRGSAVTSWTKGRSLTRGLMSLSYHLVRWAVVLPFRLGKWTIHLVSLTFKAVGHLMSLCARAAVVARVGGVSGIFKSIMGGIKHTVHWCKTGFRLYFANVKVSYYILLKRLKGHPMRYNERKLLMNTLNDALKLVPFSFFLIVPFAELLLPVAIRLFPQMLPSTFRTDNSKSDDYLQKKLLAKKELAQFFQELVQERTNQLLQDELDSSLKTKMEALKDFQERILNKKDRDINPFLSSNELLVFAKIFKKEFKLDQMNLETLKVMCKLLGITPFSVRSHVVLQLRHHLLKIQREDRLIMWEGVESLSTEELQEACRDRAMKFYNISREQLQQQLKQWLDLSSMRQISPILLLWSRCITMTHEPMAIKADDEGTAEDKLAIPETAAVEVADSSDSAVEATKPTKVGEKFAEEVTTAQKASSTRIMKAVTAAAEVDAQKLVSKEERLEELSLKAKELKDIIDGNVKPCEGEELVDGATSLDDPTPGELLEVHSSEDMLMHLHEDHVIRHAEEIKHLNALGKKEILVRHEELLSALHIQRQITDLQHNQLAEMYMFLLKVSEDLNAGVECNIKDAVNDLVVAARQELEKIEELTCQFDKHNLTYEPQASTPTPVSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3R7</accession>
    <name>A0A061D3R7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767409.1">
        <property type="nucleotide sequence ID" value="XM_012911955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3R7"/>
    <dbReference type="STRING" id="5866.A0A061D3R7"/>
    <dbReference type="GeneID" id="24563764"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203810"/>
    <dbReference type="OMA" id="NDLPVMW"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="639" mass="70268" checksum="9A7D8FF8D301E383" modified="2014-09-03" version="1">MKYLVGGSTGLVKLVETADRSLQSFSPPTEQELGRRVTCMCWSGGSSNEAASEVTVGMSNGLVVTYAYPSMERLVEFTLPSRCVYIHMLGNAIGNAGRQIYEARSAEYPALYVDTTGSELRKKQGNYMCCVSESGHCIVVDVDEIKQEVQTSFDHVSDDANDSEVARDVKSADTAGRKCKGKDSSDSAGGNGGGKRLKVEMMYSSDKDDKVQHLSISGGVAAYKFKGPITAATHSSLLPNRLALGGPNVPPFLFDIYAGKVLWTGKMPHQSLLGLQSQLDVRSICFMEDLGPDIIAVSTSNSSIYFYDMTCQKKPVYDLNVCDRRSRCISGRRLALHHIKEYNTERRKEVKQSVNEFYTSDTRNIVKLVTRPRRPSEEQDHYETKDTCDLFASDNVGSIYHFKVVTGDTLVSLLEEKMRKYQPNPDQAMSRDDVIKHLIEARKRFGSASANDTPLHCAPPGANQYICQLKGCYAIHNGAVPDIFCVGHYLISVGLDRFTNVYNVRTRKRVFRMYCNQKQTALLPFLSELYQEYESTEFKQLDVPVVKRGKRPAASGAVADRGDGHDDDGSMDVDGPGSGSDDMEDEFHDSSSNEGEFSGSDDGEADSPDGSEGDPSDYSGDDYDMSDSGAESDSDATDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D406</accession>
    <name>A0A061D406_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765895.1">
        <property type="nucleotide sequence ID" value="XM_012910441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D406"/>
    <dbReference type="GeneID" id="24562250"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100380"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="348" mass="38308" checksum="566760DB26597DDD" modified="2014-09-03" version="1">MASLKDMREMKEIAETIKSLVHLLQRGALHKDVVVPCELKTPHPDGGAGTSPSGGGQQQLCSAPPQLQHASLQAQSVNIPETCVIKKSPNLRAHQRVVYQSLVHIPRNFKEAVDWLIAVRGDDAEGNLAALGAALYDLYVHMSGRSIEWSALDKVIRVSREFLEQEKLKKRLFVNMILFLLDERLRVTPNILTTTVVSEDDTENEKYLQKKGLTADTIAEKLCCVVDACAEFLGRIKNRSHYKSAYSPQATWDASFSAHPESGAVMFVGMAPMLVASISSLNAAVFAAKLRLPPFIAYKSMQELIQALGYVEPECRAGMTASCVGRALSGFDVETITFLYQLAGFWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D470</accession>
    <name>A0A061D470_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765955.1">
        <property type="nucleotide sequence ID" value="XM_012910501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D470"/>
    <dbReference type="GeneID" id="24562310"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100980"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="297" mass="32908" checksum="3D39AE34D449D719" modified="2014-09-03" version="1">MAREQVEGNTCQCFNITCDKSSNGPCSDEKCTTCKSCCDPNCKRCKDKCKKNDPCRCHIPRCGCQEDCYGDGKDGKCKGKEKNDCKRCETKCEKGQPCLCYQCSCGTKCNGVICSCCSWCDPRNCNGKGCNGYVIGRCGDKKPRPDKCQGHVKYDNYDDKYGAVLVRTTKNVIVCDKMPHPGEECTENNCNWLGGVLQPDGNCIIYCTYCGKLCGQDKFRRCCYIAVPLVITVSAFLIFRFMLPEKFHAITTKIRAAFPSAPRHPGRSLTNLVGGGLPDVNVDRYAAFRPRTYAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4K7</accession>
    <name>A0A061D4K7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767694.1">
        <property type="nucleotide sequence ID" value="XM_012912240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4K7"/>
    <dbReference type="STRING" id="5866.A0A061D4K7"/>
    <dbReference type="GeneID" id="24564049"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206660"/>
    <dbReference type="OMA" id="KATCYPG"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000015">
        <property type="entry name" value="Protein DJ-1 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="19599" checksum="8038306157A4F063" modified="2014-09-03" version="1">MTGTVIMALIAVANGSEDIEFVTVVDVLRRAGVNVTVASVHKEKAVTLAHGTKVTADALIDDVANKTFDLIVVPGGLPGSTYCAESATLIKMLNEQKSANRYYGAICAAPAVVLAAGGILDKETAAVAYPGFEDALPKVGTGRVCVSNRCVTSKGPGTAMEFALKLVEVLCGSQKMNQLKNGMLVQADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4R0</accession>
    <name>A0A061D4R0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0207160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <location evidence="5">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767744.1">
        <property type="nucleotide sequence ID" value="XM_012912290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4R0"/>
    <dbReference type="STRING" id="5866.A0A061D4R0"/>
    <dbReference type="GeneID" id="24564099"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207160"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="413467at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="644"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="7"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="907" mass="101301" checksum="7CD8F98442EB113F" modified="2014-09-03" version="1">MAAQPVRGLVKFITDLNGLATYRERDHRVREELSKIHSRFDERGMSGYEKKKCMLKLLYIHLLGYDVDLGHVEAVQLMASSSYQEKAAGYMGVEVLLGDLPDLRRMAINTTLEDLQSAVEHVKALALSHVANSWCEELRERIFDDVLRMLKAVPIESSMLRKKLYMCVLQFLRLNSALFRLHEWKRKMFDLLSQEADFGCLMALSNLLIGFVRLHPGEWDHCVPLILEALMRLLSGTVVGERYYSLNSPWLLWKLLNVLALVEPCPNARYSNTLNHVVGRLVDRMLSIKLPTSNRPMGGGEEERAKMMAWLLRMSIALESVRVIVVWLPHMPSFSVEPVVDFLTRMLASQASHVYINALEMAEKMLENEQLLVVLKERLPQFLALFASNDPTVKCRTLFVVSHLCDKDNWNQVIPEMLSVLRESDVPTQNYAVPLLLDALQRCVPLDSLYIDFVFKMMQYVHDESVLQGVPAVLHDKPARFGELLASRCISALRQGPVNDAILRICAASLGEYGHLIEKELCCSEQARLLQRYFPLGSGCTQCVVLTTLARLAIRDRSLWEKVERFLDSQAVHPDVCVQSTACELVRLMLLGSSVLESVVNGDHGRRGPADAIESVEPKVLSISDVDESPAHNRNAVTVRRQTRAASASSRASSSSASSTPSSSSSSSRSHSASSSSSATPTAPSSMSFEDEAADGRLLRERMLSDSPGPLFDDGVLSVWVEQAYRRHEAKVMVRITVSARSARAIRCIHITSASLRCDTGLDGTEHNSVKGRLGPGEEMGHRLSFVLNRSYGELPSYKVRYVVQRASGRKEEGEATLRLPVGVHKFLTPLIAGEDHFDSMWSSLRSHESSREISVGCSMSAACEIVRRCARAHVVEVGDRGGFLTASSGVRERVVVRMLLRVCEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4S1</accession>
    <name>A0A061D4S1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase 2 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766135.1">
        <property type="nucleotide sequence ID" value="XM_012910681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4S1"/>
    <dbReference type="GeneID" id="24562490"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102755"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102755"/>
    <dbReference type="OMA" id="WYATVIS"/>
    <dbReference type="OrthoDB" id="10510972at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="184" mass="20447" checksum="7B655D24649C6A7D" modified="2014-09-03" version="1">MSKFFQLEERDVVVSSVYGAALYEIYTDRQTLPKLAKVAWYATLLSAFLLDGISILLTLLPFLDQGIFVALQRLGARVDISWAHYFSAQLLFTTVLYAVLPLALLCDRLFVWQSLQSWNLVGFALQLASVQYARCCCVFAFVARAAIGLCLRIAIADLTFKVPADEEPLDTIGGGKIALDCKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D558</accession>
    <name>A0A061D558_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767889.1">
        <property type="nucleotide sequence ID" value="XM_012912435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D558"/>
    <dbReference type="GeneID" id="24564244"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208570"/>
    <dbReference type="OrthoDB" id="10332155at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="27535" checksum="63F34205F7C28B95" modified="2014-09-03" version="1">MPFDSLTMVPRDLKEAIDWLLATKVNEDSRTWWSMGLGLTRMYERQPAAVKMLPALEVIKQITKDFLERKEIRNQKFVRSVLDRINKPSSNTTGNDPQSLKVHVGSARGVGPRTLARSACKALYVCDMFLDDIKDHEKYRSAYASDVTWEESCDEYPEACAVVLVGIAPILYVGLRSLKEAAKAAVEAGPGSKEEIHLAKVMKAVGYTVPQCRSDLTSLDIRKALRGLDVPMLAVIYDFSGFWGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D566</accession>
    <name>A0A061D566_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin fusion degradation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0104230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766300.1">
        <property type="nucleotide sequence ID" value="XM_012910846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D566"/>
    <dbReference type="STRING" id="5866.A0A061D566"/>
    <dbReference type="GeneID" id="24562655"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104230"/>
    <dbReference type="OMA" id="RPADAVC"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="277" mass="32222" checksum="3D480B6D1037A7E5" modified="2014-09-03" version="1">MRLNNGRLKVSALHKFYQWLFDQFDSIIHRGNGFFDNAPFVARYRCYPVSFLGKEAMERGNKISMPPSALNELASRNITWPMMFELRNDIKGRSSHAGVLEFISEEGMCHIPYWMMQNLGLEEGDFLTIRNVRLPKAEWVKFRPRNDNYWEISNPKAVLETALRNFTTLTVGDQIPIHYLTNVYELEVMELRPSDACCIIETDMEVEFAESRKKKRTEQKQVISGKRLDGKASVVREDETVVAKPWLNKLKHGVRTSCEEFERLLRLGRVASCAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D583</accession>
    <name>A0A061D583_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767909.1">
        <property type="nucleotide sequence ID" value="XM_012912455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D583"/>
    <dbReference type="GeneID" id="24564264"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208770"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="261" mass="28995" checksum="A18D6908591E368C" modified="2014-09-03" version="1">MVYKSLTEAPHNLKEAVDWLIALKGADAEKNLAAMGAAVHKFLADKPVGSMNVPGLEEVKLITKEFLKNPALKEMWPTQSVLRRFNEVINKEPGTLSRWFGDVYDSDYKNVIQTKGLTPVTIAKKLSKAVDGCEKFLEDVKHPEQYESAYSSEATWEKSCSEKPEACAVVLVGIAPMFYAGLRSLKVACKVAQLAPKLRVYVPSSSVGSLLLASGYQEKQWPTAMTPSYVATALKDITYQVLVTFYDLAGFWAFYWVGNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5J2</accession>
    <name>A0A061D5J2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromodomain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0209510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767984.1">
        <property type="nucleotide sequence ID" value="XM_012912530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5J2"/>
    <dbReference type="STRING" id="5866.A0A061D5J2"/>
    <dbReference type="GeneID" id="24564339"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209510"/>
    <dbReference type="OMA" id="DKWFWYP"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052442">
        <property type="entry name" value="Env_Response_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="223"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="727" mass="82611" checksum="90652615244777FB" modified="2014-09-03" version="1">MDATDPINSPEGEAVDGATVEPSARALNPGSTVAKSRAVVGECRGELTLQPDEADRINQLLSQENFRFLVYTPQPESSKMWRKPAEYESVRALSERGVGSGSFESRRSKSQFSLKSADSREDDAQTVSSYDASEKRSLRKRKQRVRYYEEFAQDLTDGNYRELRHEKPPKSQREGLKKQHSGSYERQQSQQLYRAVPILSRNLPKLPKDTWEYTAYRMLQAIKYMDTDKWFWYPVDPVADGVPNYPKIVHTPMDFHTITERLHMRQYSNPFAFQCDCRQIFFNAFLFYQPDNVIWQAAEHLAKILEEKLSNTRYLHPDEFHSLLQKGEDAMRATLLEYNEATFLRKNKWNSGSLGLDDAEAMKPLEKRKAAQNHRSKHVIDEYMYTGDDDDDSFNELSSVASADDFMLPMDGGRGRPKGFKKKGSHSKPYGLNRKHKFGDASEESDSGQRVKFVGDFPVPEVGRVLPPPPPALSTMQKASPLDKGITPSQTRTLHVNLSRLAPNQRKAALELIEDDLGILGETFMHDRTFTFDPSLLPVDKQRRVFLYVNAMVKRNIEEMHAEYARRKKPKPQPEIAIHDAKEVVRQNPSEIFDASSSSSSISDVASNFLSSDDFFDSSDDEPVSVNEEAKQRVPDDAPLPEYTPVDEQKSEKVQLTRGIMGDHADFFTHVESPPLNDDGSQGQQGKKSAWMEWKGQAIHHGTVAQENGVEPLSVDEKIAESFDARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5M9</accession>
    <name>A0A061D5M9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0210060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768039.1">
        <property type="nucleotide sequence ID" value="XM_012912585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5M9"/>
    <dbReference type="STRING" id="5866.A0A061D5M9"/>
    <dbReference type="GeneID" id="24564394"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210060"/>
    <dbReference type="OMA" id="MYTGHTL"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000299">
        <property type="entry name" value="ABC transporter ATP-binding protein/permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="44"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="398"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="638" mass="69793" checksum="C0933EA0DF0ABBE3" modified="2014-09-03" version="1">MGARPSKPMSPTSEEVEAAADVSVCDTLRRFFSELEPEEQINLALGGCAMVINAATNMVYPKIIGNIIDSGSTGRVFGPISWLPGCHNRAPALDGDEVISINCPYAMFKKLFCSALPLYVVGSLASWVRVSSMNYAIYLIQKRSRKKMYKKMLMQRAPFFHTRASGLLIAKLLNDCEEGPKSMVENAFTFLRCCNSVIGGTINLISISPCLTGVTMTCIPLFGLFIIGYSSIIKRCQRQRKQQLDNAIGKAEEVISGIESVMNFGKETDEIQSFSYSLDQCDPVSMRVCNAEGVLMGSILAGFNLSTLIMLYCGSYRMKAGDISVGNMASFILYGALFGLGVSGLSKASFMHARPITAIQITSDVSKAAVSLQRIYEIHDLEDQEDDGDILDDVRGELEFDNVSFSYDTRSEAAVLRDMSLKIEAGEVVAIVGANGMGKSTTANLLTTLYKPTGGRVLLDGVDVQTLNSRWLRSKVFTVVTQDPLLFSMSIENNLRYGNEEVSDEEIRAATRYCEIHEFIESLPEGYRATVGQRGALLSTGQKQRIGLARALLRDTPCLILDEAMSALDGSSEDLVRRIINRSDKRQTVILITHHAATLSNAQKVAVLNEGTVEYYGPLSKAAANSATFRTLFPAFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5W0</accession>
    <name>A0A061D5W0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0205600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767588.1">
        <property type="nucleotide sequence ID" value="XM_012912134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5W0"/>
    <dbReference type="GeneID" id="24563943"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205600"/>
    <dbReference type="OrthoDB" id="366374at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600631" evidence="3">
        <location>
            <begin position="19"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="735" mass="83158" checksum="29F886F81CE0AEB3" modified="2014-09-03" version="1">MGVLRLVSALMLVWLSASLETPSAVVLALPPQNGHDSTDSESVLDYEEETQILEPLNARGTMSKSDRVPQQLSGIEEVTKMYTVNGDLRHTDNKVIAPNLLEHADRAMLYVTRVYNRMEKYNHMFAGKHEELDMTLDRYARMLTLMLEDKKKLKHLSFVRRYLSHVNHVKAGVSASEEARTNLMREAGTIYQRVQESFATIKLDFERYYSLPGVVINGAVSSLIGIGEAYKMLVKLNDQMFSATDAFRTSLNRMRASSIYMFAYLLCLDILYTEILPLRMLAVQDVIVTKGTAETLISYHTNIANKREAIKALLKNGALDDKAYDEIEDIYRKVSELYERSKAIHKRTIRLLDGIEKKGTRTLENGISRVVNAWETHYKRPVLMCTKLTEEHNELNKIANNIKEERNFVHTNKQSLYTMSTLCNELYSRARELAHLGKDGVRPVGHNGYERLYPSLQTYRPRTVVDNSEFTYAPPVQPPSMILPKISSSENLMPDILTQGMKKTDKPGFSHARNHVPPSNGSSNGEVSHAYQSLKRKRPLGSDQYEEPKKLRSDDPTRPGYYIRPSGIDDGSDISQPTYDYSAPYRGPHPPETSYESSQTPQSSTHSTATETDVNDADAYTASRGSSINEQGSPLGVSERTMHDVSTSTKHHVHLPHPMKRDGATYDNDIGFDLSSVLEKLREAENKVTAYRNVILSLRRKPPSVPGAHEARLISMELYKLHILHRSFVDDATEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5W5</accession>
    <name>A0A061D5W5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0211010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768139.1">
        <property type="nucleotide sequence ID" value="XM_012912685.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D5W5"/>
    <dbReference type="GeneID" id="24564494"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211010"/>
    <dbReference type="OMA" id="AYNTCND"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2357" mass="260172" checksum="9E7543427BD3FFD0" modified="2014-09-03" version="1">MATPPKKAHLALNTTDGSNEAEGIRQAQLGMGHATSNESKAPVFSRSQRLRQSHTAAINAATGDAEWRFNLEEISHELPRGQITKALFELEQYIRDGLSERKSLGSYTHTSEVLPRVGSYVLELFLEAEWLCLSRGLSSACISVLRTLDAAALAALIQQSLASREEPRARDGLHRKVSDLHALASTEGLLKLMGDDALRLCVRLVSEVGFETHKNPESAGIVSASDVVSYHKSRISALKALNLLVLNRGPQSPCIWRDEPEFVYITNALREILRVLGNPSSDRDVLCQCGVSAIALAHAAYYADDSKRFEDVIYGFLGAHDKMARKFQGDEGQCLMSDDAVLGACELGDPEQLVNLLISLPSLGCLSVVRGILSFIYSGVSKSGAQRDTAGGNEVAQHDNSATLHEPESCAYNDEFVVESLCRCHKVFKIATDTCLRVDVNYATLQGVQLMMSFITGQTFRCEKLFACLSELPELIFTFWTRKVRRVSNLAVATWSKLMELSFALEKTVGDPTITKYTQTLIKASTASFGSNLKLRYLALQNLLKYVGPEEILRMQPFLIPHLLCSLGVPAIKGCSTVFLTELLTRIFELIQSSCRAHGVAAADERNVALVALQCLTYPTVIAVLHSRQLAIPSPANGRLVPTQNASSEQLENRACALADSFKSVFGKINKDYVFEMLRLSTTHTKCNFHKYLSRADQDALGECGVYVVKDLGDLNACISDILARVTTVSHADADERIVHLAAPFNFAESMCLCNARALNSVDFVENITLGTRLQGLIINDSPGVFKFDMETLESFPQVKLFYIPLEKVKEGLTHIKSDLCLNVVKAVACSPKKKEPISRLEMELMLYALQHCMRTSLPSFRQHFVAAVKPFIQRLLAIVTASPALLEETLSRGVDLARLENDKLVLQAGASASNGGAASPGDVRGTVALHCAYMKLMMRVMVATINPCASDFKNTTALELLHMTFHMLAEAGASVVNMTSLFCVDIIAPLYMALFYMSTRQQELIMKTLLVVPSSLLRQALTVYHGEGTLQYMVKKAAASLWSVKTVPYMAGAKALTLLLRGLQFSQSVKTALGTGDLYAAVHVDEPGEPETEHEAVLCVLEFFSQRLKRVCDSLDVHINVNDAERASCPAGLLSLLSHYMSSTPVHVYSKVVNTTRFSDIVGALYENLKRIASHILKYVGREYGQEEGSSKDYKIDCRGHLVTQHRTYDFTCTAELEKNYLDCTVCSGDFKCTELRLPSTPKCSVPDDSNLRPFTVLCWKSVFEFCNAMRSMLQWILPQTVNGAIALDVIRSAEGEDPGTNIPLFYDRIDDIGRYLIEALMSCRHFGCTDAFGDLMTWICKKLVILGLHRPLKEWLTVLLDLIKGYTGSDRQYAELFVMLRDSHRRSEPIARSFTSILKAESDRHKPILLPLVVDTLLQLTSTERPLYGDSDNDFTAVDIRIHSLNILCALFRCKELRWSNNIHAGSALCASLRNMAHGDWSVRNSASLLFSSVLHHLAGSDVNLASTDALLDQKLSLCNNAELSNQLNRILVSVKEMTVYSSESYEDLNPTPEYSALYQSSAFVFNFLSRIPMYSFPPDVAFTLSENVAAMLYSTNASIRVMAAKILAKNCMDTSQMNIRTLLVQSCVCILEEAGRSNHVNGRLMLITECLELMIANGLHDVWGPSTSEENTLHQLAEVERLISTGFIKNLISVVNAKTPAEGLLITMYAVLITANCFENVLQVIIIIEKMCLLHGKAADFDEMASYVQPSSSLETSRMLHCSAVLALAASYLIGEDVHQQCIATIRTMPRHVPMRNVKLESLLRAFPGVTVDGMTKVRAASALVNSTFLLSKAAPPVNGKLEADFTSFVQFIAHLLLALHGMTSHQRALEAALGRVAHLLEHPQLLRCKPEGLARLWEVGMHILSTESHFFICISTLRLFNAIGQQHLREHTAANGLFDERWAAKFLSVATERMMYNSDYVVEAWKGCHLYALLRQGSQPVDARIVQLGAGMLLKMVDPGTDVAVRTAAAHFLEEHGIPRLQRGPEAQGATGMYGLHAIVALFVMLQDETENVRAMAVSACSKTLAAMDGSHMSSMKAHLCMEHLLQYALDTVPVAWLVRLFEQLTMLNKDLYNQINYKLELQQQSVQRQRLCLTTSEIDSTAGEAVSDITTLAEMDTVFNVEPQNMYTETLLYMVNVDRLLCRLASACVAGSSPPTAHADKLATLHQFLDDNSNRILRTLTGHLLDNYEVSQSLYLSHGTQIDIKQVPHAAALALVADPLVVSCGVAGFARSCLYVLWPATDGANGHVSAMCGGHWERVNTFRQVLALAGKVWNAQVTEVGGMIERIRSSGKCDKRDTVAVLEKLAQFLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5X6</accession>
    <name>A0A061D5X6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768302.1">
        <property type="nucleotide sequence ID" value="XM_012912848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5X6"/>
    <dbReference type="STRING" id="5866.A0A061D5X6"/>
    <dbReference type="GeneID" id="24564657"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300210"/>
    <dbReference type="OMA" id="YDECETK"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600081" evidence="1">
        <location>
            <begin position="19"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="371" mass="41759" checksum="65A28D5E19B59E68" modified="2014-09-03" version="1">MKLRGIIGLVAILGIAHAQAWGFFGEEPEEDLFADKKCPYEVLGVKKSATASEIKRTFRQLSKKYHPDVSKEPDAAERYKEINEAYDILNNADKRKAYDEGGFAGLMRQSQSGGNDDGYDINDIFSNIFGFGGGRRRDEEMRAEALVYPLSIPLDVLYHGRDLTIKIQVNRLCPEYDECKVNRKDCQAAGVRLVTMQHGPGMFMQQQVRDHTCIGRHEGWKTSCSACPNGPTYVEDVNLELTIEPGAKQGQQIVMEGRGQERPGMKRGHVVFVIEEKPHQIYRREGNDLHRTMDITLKEALLGFDKTIDLFGESIEVAESGVTPHNHVIKIDQKGMPSDERGGFGDMYVSIRVIFPRRLSAEQIALIERAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D679</accession>
    <name>A0A061D679_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0206800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767708.1">
        <property type="nucleotide sequence ID" value="XM_012912254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D679"/>
    <dbReference type="STRING" id="5866.A0A061D679"/>
    <dbReference type="GeneID" id="24564063"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206800"/>
    <dbReference type="OMA" id="ICSRNAF"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR95522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="787" mass="85331" checksum="92CF4798CFF6972E" modified="2014-09-03" version="1">MDGSTRKLGAKRRLCGGDVAAAPTSAKRPATAPPAAASGNQQELLSLFTDCMSALSTNKICSRNAFEIGFIDHMTDLVHLDGGSDDEESIPEIPSGDAGSAASRRLNFTRASKVVESASKIYGYRIEAIYDQTFNVLMSMNSANQSEGGGSFPTAEKPRSRARAKVDYTSGSRTLAPEAEVTLSEIPVDNVVLDPYFLKISSMFDQSGAQGLLLTNLQVTDDLSLDLDGDSVVFSAPNSMHAETGAAYLSSDSLREVALRGVTDLSKLEILPEASYFRNQLQRLQDLKRRRQGGAADDLDACVEPPPEAESLMDLPDAGYAIDMYDDDYACDLALTQPDAGMEEPSYGFLDPGSDGYLGAGFATVSMNSDGATVASIANSNSSHASIASSVTLPQRLIQALGGTTMSIKQRLAEIDLFGGSQFSYYMPNIKMTTAGNERTAAGPDGAVAGRKTDKSVKYRVSDYKDILAFMRARSAAEEYDSIERINGLLQARTPLRPHGIFTAPDYTASIFKFSDAFLTRLCTLGNRILRLANDNDWRTLQAENQAPPVLHIHYTRDHEAPFSFMRIGENFSWKEDEEVGFSRDEDAWFAYQDVVEGSASEFGLDEMDSDAMHVSASQDHSMQISIDDMYEDDTFDVDLPRSQPVDVGSTLEPAPEATHGALVPAPVAAYVDIFKIKKTLCSVVLPPPDFQEALEKGSSHGSASASAEPRKETSCMFQRAINETLDRLQSSDVAALSSHIMFVCLLHVCNEQNLLLRQGAALEDFQICVDAPKEHHLGNFSSTLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6A9</accession>
    <name>A0A061D6A9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767738.1">
        <property type="nucleotide sequence ID" value="XM_012912284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6A9"/>
    <dbReference type="GeneID" id="24564093"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207100"/>
    <dbReference type="OMA" id="CITMFEN"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="281" mass="31000" checksum="1AF65A995BF508FA" modified="2014-09-03" version="1">MGNSCCLGRYNEYRAKLSEIESHVIDNISSYGPISDLLGLEESECDIERFDLAFENGDINEFVALCGSTQPIDKFEGRLHPWAANPTTIGALAATQLAIFASLEQHPEFKDAIREASGIPILVEMLRSNEVDRFHVAVVALSFLSAGNIDNCVEMFNAGALKDLIQGMKSDIDGVRAACAQICRNIYQLGWSCQVFVKLGGLVNLVRFLSPCDDTDEELCLTQLEAIYHIEDFIMDGVEELPEFVSIVKVSGAREKLKLLEKSSNKELSMAAKSVRVRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6F7</accession>
    <name>A0A061D6F7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768452.1">
        <property type="nucleotide sequence ID" value="XM_012912998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6F7"/>
    <dbReference type="STRING" id="5866.A0A061D6F7"/>
    <dbReference type="GeneID" id="24564807"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301700"/>
    <dbReference type="OMA" id="IAIYPCK"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596014" description="MACPF domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="2">
        <location>
            <begin position="45"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="637" mass="71762" checksum="76F6120CDA840A55" modified="2014-09-03" version="1">MNKTINRLSWVYVLPSLIFFSVRTARVGEGEVRRKERFPVSLEKQLEIFKDTNKTPKNIEYVGCGYDMYNGTSIDDRTGFSLKNYRAPVLDKYYTGESEGNQLEGLGIWVANEFQCDLSNELSSVDTKQNLMSLISSKTSDGYSNIFSSSTSETTKDDDILNKLKRSRSIIVRKYHCTVYSAGININDIWKNSTRFNGIVKRLVDTCKGGFKEVECPIDRLKKNIYDEGCEGCIASWMRFFADFGTHATQHVTMGGTYRRFNNAMDKQASRKSKKSEVTITTSSSWFGLSNSRQESTKENEFMHSRDDEENDVVQYTVGPEPKDEFMTPDSFEDWVRKVALNPVPIDVEFISLSELMPDDETRKLFKEALRYYAKLRGVDKNDTHITNGALRSSILQLVSHAVNMIYRVRLWSFIVLQLQESTLVAINDPDKVGKDVCKGESKIIFGFGVNLNEKRQILQLKPCYPGLNACILDLNQDVVSTFVIALCGEMQFYDFTQKLTKGSSDKSTYNEVVCPKDTVVVFGVIIRFGYPMMIRECPKGIRSCGDRNLGPNGLIWVACLPKNTFGINLYSTTAGVLGAGEKLPCDSSSKVVNGFTILSTRDNKNVRVAACPKYEVACHAPSQNEASVGSYIFCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6H1</accession>
    <name>A0A061D6H1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768339.1">
        <property type="nucleotide sequence ID" value="XM_012912885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6H1"/>
    <dbReference type="GeneID" id="24564694"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300580"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="262" mass="29123" checksum="FE29B54B45EFFBB6" modified="2014-09-03" version="1">MAAAKTKEMRVEGNDCNCLNITCGQVADGPCPYAECKTCKSCCSPGCEGCKVKCEANESCKCYITCCGCPTDCYGDKKNGECKGKESTNSCKRCENRCTEGPCDGYVIGRCKDKGYDKCEGHVKYHDGNPVWERKKYGDKCMDSHPYACNENDCKWARGKRDENGNCVLKCTYCGTLCSQDWCRIWLGVLIIGLIILSCFIVMWGMFPETFHRMTTKIRAAFSSSPGHPGRSLTNLVGDEIPEEMNIDRYPAFRPRAYAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6I0</accession>
    <name>A0A061D6I0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768349.1">
        <property type="nucleotide sequence ID" value="XM_012912895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6I0"/>
    <dbReference type="GeneID" id="24564704"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300680"/>
    <dbReference type="OrthoDB" id="10440482at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52056" checksum="1003A0AA43C484C9" modified="2014-09-03" version="1">MTQQGYNKTVCGLLLHIQLLACSILALFGVAAVANRDVITCGVAFLSAALIASVCVTLNNLTVICNCIGQVLIGIGLLYINYHSLHQAHPWITLVRYSTVISVFFAISSISVVCSVALLNLHGSKQTSLDENLFNGAASAFVTFEEYRAETYSCDEDPLLNTDTSIEIRTDNEFMSGGGDREDGQLTKGPEMAFSKEINTNMWDWVTVDDSNADDNDSSQQTQVINNSVLPQTDGNCPMYSSFDATFTVREPLLASDLSSQQSAVDYGVENKHVDITGNRSSNYTSGTDFWGSNVPNSHENNAGINTFLESEAMAENRLESLGPVMPAPLRNEDWKLSPRNPHSAIAWGGSIASRSNYVDIATANDPPMHHSLNSPRGYLQRADDTAITGQTLISSPEEAHIPTAGLQCIPVRDGSRLVLHRKELVSSSEESIVSKANVNTARYNLISAGDSLLSENVVGKQPFKYGVEFMSDSRYSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6I1</accession>
    <name>A0A061D6I1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768472.1">
        <property type="nucleotide sequence ID" value="XM_012913018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6I1"/>
    <dbReference type="GeneID" id="24564827"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301900"/>
    <dbReference type="OMA" id="LVYNCII"/>
    <dbReference type="OrthoDB" id="360884at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="817" mass="92062" checksum="1EBAE1735F028C21" modified="2014-09-03" version="1">MPMSAGVESYEAGAIPSTASVSQTLDIVAGLLRSYGRIDGYISQLRLPEAARLLGVCYTDQVSLCRDGEVEEEIQVCCASLRDKCLSEVFHLSAVSNSEYVRVELERYNFRRRLSEFESGSADGADCSALFQQLLEDAESDADGIVEEAERVLHALKWAWYRRYEMLVKLVLFVARRWLSFSEDDSADGNRQSVTLHQEEFHIYYHELDECLVLLNMSETYVRLVERCAFRYVTPVIRMPRDSGCAEEDSIDYVHNKCLGAAFTSKEDATIAIEGYSSTSKMLAGVVARIKSVESVLRKLLRLSEECEWSSGVAQKDSARQVDYLTVELSSFKCMSEVHIRVLTAELVCRLVESIYPCWELEGFGFEDLLHSFRGLCDALRYAELMRDDASCRFIDRFFKCVFDSWEGHVLAFARFCGRSQNDESIMQAATLSKADIRRGMFVRRADKTSVITLLGGLLDADFRGVDISEAFASFDWANKMETCYVSNHVYTLAALLFVLAAKPLAILRQGFDLLGSGIVSQCVISSCVCRYSEMVSSVITTYVLMTQDSFKQCVLSVAKSVGKDEDAKNIGDLRVPLTMFFMFMSNVSFMSSTCLVLPYFAQEMEARVQFGPDPTSGERCRALVSDLVKRHFHTCGLHIHLLKVQDYLLTQVTAFLQQVLQKLLSRVLNAINEVSEGFGEDALQLFALSSSLCESILPSTLRLTTLCLILDLYFTTVPDLFLDYLDLLNYQPSDSMLAIITTFIVRLEGSLSSYVLDLNKDHGDFVYFEKFTAFAGVFRQDFSGVENANSTFNQRDLNRLFKLCKFIQGRSGVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6K7</accession>
    <name>A0A061D6K7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766765.1">
        <property type="nucleotide sequence ID" value="XM_012911311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6K7"/>
    <dbReference type="GeneID" id="24563120"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108770"/>
    <dbReference type="OMA" id="ARKVEIM"/>
    <dbReference type="OrthoDB" id="360242at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="64525" checksum="E7854970F64ACA9E" modified="2014-09-03" version="1">MEYIGLLCDGIGGDALGVLTCFLDFEDFLKLATTSRCMRDVLLSREQLWGCFFERGSVGCNRPEDLDGITGKGRQCRCQYRIRPFSEAIAGFKALADLASQCGVFDGRRKLDGRALLDLAISSGTHSRRVTVDRDMVRDLRTIGKTILAISRDGVGWPFAVLSANRILGVGTCREFFDLRQPTPIFDRHTFQLVACCWVRSTQCPRCSCEGGGCVDQTPPKQVEDSPSADRPLTLAMLYTCRGEDACVSVYNYGESGLERNPVVTWKIPTGYNPVRCLEVVQGRGCGHYFAFVGTDEGDIHCIQAGTASVIATIRSPIDAITAAASGGKVVLCVHAAGDIAVLHQEGDVTHVYRVEEAFVYAVDTENLLLAYCAYGKCTVKIGRFTGPDVQLRVTKPPSFILYLHRRSMWALVMRNYVKLIQVSGCDASLQVKHLRVLNGHREDITACHADGWSRMATIDAAQYLIVWDFIRGVKVMGMALITASASLGLPKLSRKEVDGTTRRRRSVNSEISYASLHNVKKDFNNPPSVSYGSAASDSDEPTRFGMERLSTRSSSSHKHTVYISLDTICVYYHHMSCLQVITLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6T5</accession>
    <name>A0A061D6T5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766835.1">
        <property type="nucleotide sequence ID" value="XM_012911381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6T5"/>
    <dbReference type="GeneID" id="24563190"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109470"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109470"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="302" mass="33269" checksum="7C82776A8E9A08DC" modified="2014-09-03" version="1">MAGGRMAARQVEGKDCVCFILSCKGENELCADSTCTTCMACCSPGCKDCKEHCEKGQKCRCLNLCCGCPTNCYKDGFGEASCKKKNQTKGCKRCETKCAKSERCICYQCDCGTQCNGFLCACCYWCNPGKCKRKGTCDGFVLGKCYSGEGNKKCKGHGTYNDEGRPEYVDNCTCEPKNSNSGCTCYKSKYDNKCRCIRGVPDEYGNCVIKCDLCGKLCSQDSYIHQGTLVVVPLAIAMVLIIVWCKYRDIIRKVFYELRGSSSRAPKHSSAYTNNLVGDKIPEQSSTDRYSAIRPMPYVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6V1</accession>
    <name>A0A061D6V1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">3-oxo-5-alpha-steroid 4-dehydrogenase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0303300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768612.1">
        <property type="nucleotide sequence ID" value="XM_012913158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6V1"/>
    <dbReference type="STRING" id="5866.A0A061D6V1"/>
    <dbReference type="GeneID" id="24564967"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303300"/>
    <dbReference type="OMA" id="ATMPIFN"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="146"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="295" mass="35339" checksum="6FD5C388942A40F9" modified="2014-09-03" version="1">MNLLLKQCNGAFIERISVSEDATVKDLKQLFYEKFHFYPQRQQWNLGSADGPRIVEGTLKQCGVLEDSSLYFKDLGVQISWRLVFFLEYIGPLMILPVLYHFPWIFYGSHVAPKSNVQFWTYCMLMFHFMKREVESIFVHRFSKTTMPIINLFTNCFHYWVLCACGIGYYVFHPRYTEIRLFCRHEKVLLVLMFFFFQFMTFMTHITLRNLRPKATKVRGIPQNWGFQYVSCANYFWELLIWVVVALFTNTVPAYFFTFAVATILCNWAKKKHQRYIKEFPHYDKTKKAIIPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D776</accession>
    <name>A0A061D776_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0110620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766950.1">
        <property type="nucleotide sequence ID" value="XM_012911496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D776"/>
    <dbReference type="STRING" id="5866.A0A061D776"/>
    <dbReference type="GeneID" id="24563305"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110620"/>
    <dbReference type="OrthoDB" id="365160at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="266"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="656" mass="71598" checksum="DE73EF5366EB378E" modified="2014-09-03" version="1">MDLSAVVDAGRKETADASCTSASPKRVSPSGRIALRLVSPQGRPSAEGDSAKPLQHVQDSNLTQRFRRGMDDKGTPKRVARNRGYRKLVQSTWHGALDGAPLVSDLAVNLKSADHMDTAVAEGSSSDGAEMVAACSTMSTPTKCAENNQFTTPMIATSRSCPSESRIKRQHNMESRLPSPTHSIARDDALFLDCESHKEVEEFLSPMSVDTGGFSSVHETIEIRQILESYYTNQPCKPIEVDGASQEDLPSVDRARDNTPAECAENIKVVVRVRPIDDNGIPAIRLVDNVVEVHKPGNVHSVLESQRPKVYRYGFDSAFDGGASQQDIYEATAKDLVPKAFEGINGTVFAYGCTSAGKTYTMIGDEKEEGIVQLSLKSLFELRQELYPDALVHFSFMQVYNECVFDLLTTGNRQLDVQEDNGEVRVPHLTVIRVDDCDSVLVLLAKGIKARKMAMTDANRQSSRSHAIMQITVSTQHTTARLSFVDLAGSERAGEGEARAERLKESSYINQSLLALANCISGLADTTSRKARIKYRDSKLTLLLKNALFNNAAVVMITAIHPGSQFMSESSNSLKYAQRAKEVKVALEAPSAETEEADYAAALKEAYTAIAHIGQMLPESVHNAVIKSLRASPLSGKHAFVSLLKTLRKPSHDTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7J6</accession>
    <name>A0A061D7J6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768704.1">
        <property type="nucleotide sequence ID" value="XM_012913250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7J6"/>
    <dbReference type="GeneID" id="24565059"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304220"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="63" mass="7118" checksum="1809BA9C40059DAC" modified="2014-09-03" version="1">MRDMKPKEDYDFVEDPQAQTGWMPAWMAPKTIGNGPTWNRQPTTGALGDNLVKFKTGPRHVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7T9</accession>
    <name>A0A061D7T9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Triosephosphate isomerase</fullName>
            <ecNumber evidence="10">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0201310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic and gluconeogenic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18586"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767160.1">
        <property type="nucleotide sequence ID" value="XM_012911706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7T9"/>
    <dbReference type="STRING" id="5866.A0A061D7T9"/>
    <dbReference type="GeneID" id="24563515"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201310"/>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000016">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="265" mass="28611" checksum="F2C2F92C2A05211C" modified="2014-09-03" version="1">MAVVRRRWLGGNWKCNGSRELVSTLSAVMNEAEFDVSTMGTCSFSSKHSVSDVVLFPSSLYVVPCLEKFKLERFKVGVQNISQAKPGAFTGELAVPMLSDLGLEWTLIGHSERRSMFGETDEDVAAKVAITQQAKLNAAVCIGENLTEREDGLVGEVITRQLNAFMAAVTDWSLVVIAYEPVWAIGTGKVATTAEVLEAHQLIRDLLTEKIGAVADTVRIVYGGSVNENNCVDLMQTPNVDGFLVGGKSIAPAFCEIIAAVNNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D823</accession>
    <name>A0A061D823_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0307100</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768992.1">
        <property type="nucleotide sequence ID" value="XM_012913538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D823"/>
    <dbReference type="STRING" id="5866.A0A061D823"/>
    <dbReference type="GeneID" id="24565347"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307100"/>
    <dbReference type="OMA" id="HQGRYDR"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="35"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="395"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR96806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="509" mass="54920" checksum="4685794E9252BDAD" modified="2014-09-03" version="1">MESAFDVCAGGISQLSEITLDKISRKITAADIKNKRTHIVCTMGPSVKTAETVVALIDAGLNVCRFNFSHGDHQSQKEMLMKVQSAMEQRPHANVGLMLDTKGPEIRTGFLKEHKAINLVHGQSLKITTDYTYEGDSECIACSYPKLTESVQVGSRILIADGSLTCEVMEKFSDHIVVKVLNNATIGEKKNMNLPGVKVDLPVLGEKDINDIQQFAVPNNFDFIALSFAQSADDIRECRRVLGEAGKHIKVIPKIENMEGLRNFDAILAEADGVMIARGDLGMEIPVEKVCIAQKYMIKKCNEASKPVITATQMLESMINNPRPTRAESSDVVNAVLDGTDCVMLSGESAGGKYPVDCVEIMAKLCFEAENCIANRKHFANAIAATNKNLSKEQALARAAALVAMEINAAAILSFSADGSLTHYISGCKPTCPVVSFSTEQHVTKYMSVCRNLMAKRLPAYGNQESDINAAIASAKEMGVVEQGAMVVVAYATGSGAQAADNFVRVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D842</accession>
    <name>A0A061D842_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIBONUCLEASE P-RELATED, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0300670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768348.1">
        <property type="nucleotide sequence ID" value="XM_012912894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D842"/>
    <dbReference type="STRING" id="5866.A0A061D842"/>
    <dbReference type="GeneID" id="24564703"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300670"/>
    <dbReference type="OMA" id="EFEIFSV"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="282" mass="31072" checksum="5F38E3F63BDFCA02" modified="2014-09-03" version="1">MIDLNVPWTTASDASTWLSAAQLRGWYSLGFNVYCRADKMNVQDIPLNLPPYDFKGQEQGTEGKIVTTLGRQLPGGATFIRRVTVMLNDGFQPNSFNKIAEGRDYDVVAVMPTTQKTFQVACETLNCDLINLDYFCHYGTFKVKRGMVTAALHRGCFFEVTMATLDHLGYQDEVMSVTVKDRARIFRAHLTSVLHYIPLKRLVLSPGNLDPTNVVDPPTFIGMCNELIASATGESCDASACVTAAPKGCIAKGAARRTYGTGILVHMAEEPLGKRFTSLNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D864</accession>
    <name>A0A061D864_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0307700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769052.1">
        <property type="nucleotide sequence ID" value="XM_012913598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D864"/>
    <dbReference type="GeneID" id="24565407"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307700"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600679" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="828"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="957" mass="108193" checksum="227B0FB6AE65AEB3" modified="2014-09-03" version="1">MAKFIGAPLAICTLILQLIGFIDALEYDFISGMSSLDTNPLVAYNINMDDIGMATLACPRQVNGADYVWHHQTNADNDDILTIHVIDDGKFHSVPFSSVVVTEAPRPYVRKVPKESQTELHIDLMDDDIYAITAERLVFICGPRDLVLGEALQAQLARLQEIYEIEVYSWEFRTPLIEEIAKIGGSLGVVFLHRGLKHKLLQGCGSRPSPLFASDYVTVDSETGTRSCMVDPMSESPIGFICQGRIEPDDCMRYLIDSTDRVVPAPTPHLYKHVYNRGNWVIAQYFNGVALPRFNGECRCIDPGTGHVKARMEIRWKTEYVCDIASMVVRNRVKPIIGPWCSVMLHPGATLTIKLPKQTDKFAATGEEYEDDVEDIDDDASTVPLSQLPSTHAYDSEFKPDTALTLRRRQTIHDINLYDEIWINEVFTGDVLEVDVSQMERGEVKLKYRMDRPLALRRGYNSFLYHWTFISRNENVLEKIRAVVNVSFAPTYCYNIIGSDRWKLGMFNPAHDIGSLTIRDMRNGMALTSEWLLNVMSGEKQAGIQCGPNEELFPDNCESTGYDLSSNQVAPFPTSVRNVTLYPVRGFQVFAMSFQNVPVSHSCSCVNEHGYETSRLILRSNRREEYTYTVRREEAYQRSLPYSLLPWSEVALFYGVSNPMRSIVLHNMPQRPIKLHSGTEFFMRCVVDHALYNGENNAAALPLWLPYYIRYNHYKVYTTAEGDMLIPKRNEDRIAGSKSGLDIIMSEYTDEHCDLMIKSNSGAILVSRDPDHSEYVPMTLICGKEILESDFGQINDDASAADIPLPLTPLEEYTWNVIQIDVEMTDPYMQGCGVTYESDKLFKPETPKLYDSIGQDVGCRIDLQAAKEAAFYCPAPYVLDPPDCFNQVLVKGETKNVTDVSKSLGASHTNHFVTLKFNSELVGPRETLRQTTPLECRCVTVKGIVLSTIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D866</accession>
    <name>A0A061D866_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0202710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767300.1">
        <property type="nucleotide sequence ID" value="XM_012911846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D866"/>
    <dbReference type="GeneID" id="24563655"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202710"/>
    <dbReference type="OMA" id="HELNCEN"/>
    <dbReference type="OrthoDB" id="364359at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="427" mass="47677" checksum="143A07EFEE2A53DB" modified="2014-09-03" version="1">MSDSAPPPTDGGGESDVAFRLECYGAGDSRVLRYFNGAIIREAALKDYFSARAEHALSEDASLDAVIARGNHENWHIAASTICVAASIWAQKSNPVEWDEARVYQQNANQVFAKAHALLDCLQSSRRLRLGHTVASQECNSQVVKYAIHSRNTRLRECAARARELHDVLSRSLRLQVNFLQVLSAIRSQFKVLINARNLVDVSSFDVDYPASFSVFVVFYDMALQTDDGESRVWESWDVHKLSAPGAPQQCLLSYYEDTGPGDGLMTKMTFPTAVSFFIEHDFALTVNGAHVPVYMREDHSPVVYRLRAAQMCLIDRYIFLTLCQAALEPLRSQQAIAVNGVDVFIQSMTSERISFSIDAQVVAVRYAAAAGQETGDVTWRLAVTKLRDLAIQNWKRQLYQREADTPCLLLSFLSYVTNLLSKFSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D871</accession>
    <name>A0A061D871_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0307800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769062.1">
        <property type="nucleotide sequence ID" value="XM_012913608.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D871"/>
    <dbReference type="GeneID" id="24565417"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307800"/>
    <dbReference type="OMA" id="NFCEECC"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600681" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="747"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1609" mass="179038" checksum="2DEBF177F7AE79C7" modified="2014-09-03" version="1">MEVLHKAQQWLPLIIAALAHLVCTRNANEFYTFKDATATSVYVTNTDDEQKFGPARAFQIGASYWCSAGSHTSTDFVSWTGELWDLAKVSQIEVIWEYAPKEVEISTSITQDSFNVVMPFRETFESKPSYKEVFKLDLPVEARYVRLTLRGAINEYFGIREIHIVGAGDPMFVIKSGISTTLGEMCLQLEEGRTENNTRVVLDLCTHAIAAADGRDLWRHDSRQRLVSAITSPPKCLTSVSPNKIGALVITECNDEGDEQCRWEFMGNGQLALKNVSDLCMTQAALYEDKAGMGNLLNIMKSKIQIVASSTTDRHGAELAMDGDVKTYWASELFLDSNIHSVNLTINFGESVHAARVRIDWEYQPTTYIIEGSTDNIVFKELARNVSNSDHITIDTLAMKAFKQLRIVMLRPHHSMGKVEGGFVYGIREVEVLTSNMETVLGNCRAAANTPDARDKYFVSYVSEFEPGLAHVIKNMEDEIHNMTGEIMDEMATLNDTLDETDACMQDKKEYDKTLERVHTKETALWKQIQASSLCDKSANTEVMYSTVGETMKNAAEDCYVIKQMMGNPTSGFYWIQPRCSKHPLRVYCDMNSQTSMFIWNGKDAHAAPQSLQSMTSPLAIRYQCAAFGLEPLVVKSKHQLDGLKEALYIMGFEKKTEHYVPLAYKFGNSHKFRDLMNIFSFMTDSAIIETNAPGDKTDEVTQALHTVNHNAAGLSLETGEVEKFDLEAANVEAIVCSTNITDDNVVPIDIKCDDRIDKTEALVANTNTNIVVRCSEHCAERKELPVYGVDGVYSERSSICRAAIHAGVIASRGTFTVAVESGLPFYSGRTENGIQSYAYNKAWQGAKDILDAQMPDDEKEVEHTGPPSKFSIRILPRERLCPIVQTHGSFLQVPNKENEKAGKSEGKGQSTAVEKPVPKEGDKADSKGAPDESEVMDITDLDPNTKTEAAKVLTEMNAMYGMDPKTVVNTVRNIAALVSRAKKYIKPLESITRHQEKQMNTMFDRVEVASQKATHLKEVKESHKTNYERLLHEQQAKGVESEAPITLDYTKMAFSKTFRVYDTSMTSGGESRWGYSDAPFEGHQSYMVQSSDVDSSLLGEGAFAILNNRRYFDFDLKVDVLAKNDGAVGVAFRVQDQFNFYLFVMNSRQSHKQLIKVQDGVALVLATNPDEGYQKNKWIAVDISATSNSVVIKCDDKTILRVLDTSFLHGAVGLYSCGSNGNFYYDHFSVSPKAQVKEDRTSNEARLKTLKCCTYNENFDGKFSSAYTVVTPHHVHATSWRFKDILGGKHKAIHQRHSAQDALDIGSIALLKNARMCRNGHMKFRFLPTCEGGVLGAVVRYADINNMVLVEISWKELRIRHIQAGAAKVLVTVPAAFAVSKWNVMNVAIDDKSISVKVHNNVEHGSFLTSIFKNADFECSAEIGDDSALGFGLGLKASACDSSYFDTLHISPEENNQALPATNLIQQYSAANLWKPCVENVHILSRVGLCRQMYRNKGNAHVCAESFCAPCCSYHTTLLGDVHQQACVAECQKNNHLVHSYLERFLSYVSSCVSLKGVGFDHCEGDRQCLRQACKLCCGSGHRENGPLDKNLMALETSSCLAQCNSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D896</accession>
    <name>A0A061D896_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase Rpb4 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0308100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769092.1">
        <property type="nucleotide sequence ID" value="XM_012913638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D896"/>
    <dbReference type="STRING" id="5866.A0A061D896"/>
    <dbReference type="GeneID" id="24565447"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308100"/>
    <dbReference type="OMA" id="PEFKNCK"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="127" mass="14745" checksum="77CB5C5FB134D24B" modified="2014-09-03" version="1">MDLTREPNKVEVDEEFKNAKCLNLCELHLILGDQLRLQHKRNEAAKQLIKTSHDYASRFAILKFRSAIVDIRTWRDGSLHEFEMASLVNLLPKSVDEAKSLIPSLSRIPDERIDEILELLESYRVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8B3</accession>
    <name>A0A061D8B3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RuvB-like helicase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0306670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768949.1">
        <property type="nucleotide sequence ID" value="XM_012913495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8B3"/>
    <dbReference type="STRING" id="5866.A0A061D8B3"/>
    <dbReference type="GeneID" id="24565304"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306670"/>
    <dbReference type="OMA" id="AMGICGQ"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="101"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="494" mass="54316" checksum="FDBA340A69DFBE93" modified="2014-09-03" version="1">MAAMGVVKDCVPELNTIKAEGNAPKVFKEKISVHSHIKGLGVNPSIFEVDTALINSTGDVSDPRYQEYIDCFDVGCGLVGQYRAREAAQLAVDMIKEKKMAGRALLLAGPSGSGKTALAMAIAKELNTSAPFTILSSTEVFSSEVKKTEVLNEAFRKSIHIILKEEKQVYEGEVTELVAEETENPSGGFAKCVSAVVVTLKTVKGTKTLRLAPQIHDQMVKEKVTIGDVIYIDASTGQVRRCGRCDAYATEFDLEVEEYVPIPKGDVYKQKQCVQEMSLNDLDVANSQPTGGNDVLSMINQYIKPKKTEITEKLRLEVNKAVNRYIDMGVAEVVPGVLYIDEVHMFDIECFTYLTKALESPLAPIVILSTNRGLCTVRGTDSIEPHGIPVDLLDRLLIIKTLPYTIDELVQVLRIRGKAENVPLTDDALLRLGEIGANASLRYCMQLIAPANILREIGQSDVLDRRFIDEADSLFMDCKVSAQRIAQQSHLFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J2</accession>
    <name>A0A061D8J2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769009.1">
        <property type="nucleotide sequence ID" value="XM_012913555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J2"/>
    <dbReference type="GeneID" id="24565364"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307270"/>
    <dbReference type="OrthoDB" id="366205at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600696" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="83" mass="9394" checksum="7699B31775C1936D" modified="2014-09-03" version="1">MNVIRAAAALLMFLAGFTYADGDAQRRQQCIDKCVTKHKTKVMRPMHRLLCKISCRARHGAKIEESLVYVHPAYNGKDALFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U0</accession>
    <name>A0A061D8U0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0308660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769149.1">
        <property type="nucleotide sequence ID" value="XM_012913695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8U0"/>
    <dbReference type="STRING" id="5866.A0A061D8U0"/>
    <dbReference type="GeneID" id="24565504"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308660"/>
    <dbReference type="OMA" id="KVGFQGT"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="8113" checksum="6AB7F1491ED088A3" modified="2014-09-03" version="1">MTALLSLPSFIVVLLLTICTSSYLKVFLPNYFNARRPGFFGLLGKLAVIGDRLSPYVAFCCIVCAFWILFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8W5</accession>
    <name>A0A061D8W5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768598.1">
        <property type="nucleotide sequence ID" value="XM_012913144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8W5"/>
    <dbReference type="GeneID" id="24564953"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303160"/>
    <dbReference type="OMA" id="IYVKNNW"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031151">
        <property type="term" value="F:histone H3K79 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOT1" evidence="2">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="608" mass="67312" checksum="99683993A286D943" modified="2014-09-03" version="1">MDHLIRGRHMSSKRVYSYAADEDDALRSACTVEPGMLYGVPKRRQVASQISADFRHVEPVSEPADIAAGYASHVVTGSIGDFPDLLNHRHRCAGHVQRTVSTPCSDPYAEYNQFARSLFRRVYYDLSRGIDVVDSGIGYLFKSSINDISTSTYGMYGEIRPACLMKICDEMRRFGLDERSVVVDLGSGRGAPNFLFAHHVRVFASIGIELCPVSYALSVHNLLHYLKVDVARSIRENTCFGGVGVGGDGVSPIAAALAAKLSTADSDNAMQTPRRKRHTKDYNEDDTSSCERTASGVNDSVVTQYEGGSTYADSTSATPTKEMISSNDDGEAFYRAMHRVSVTPSSLGVGFCNEDISAFDHFEGASHLYSFDIAMEKALVNNIVRQFANTRSAWLYASFNGDLIERFELRDCFLASRIPCQMYKSGERRFCYIYVKNNWERLKMEHDAAISEMFGLPLPMNCAPMQPKVASSGRTLRPRRSQTPAHGGDAAAPAAPAPPLKSVKSVLLSQFDEPVGVIESVKLAKMPLEAQIGWYSKKIARPQEVMTRSKVVNSIERVRMGFVSHRSKLLELIATSPDPREAAKYVGLLRRHIQQKYMPMRSFAPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D959</accession>
    <name>A0A061D959_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Merozoite surface glycoprotein gp45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767625.1">
        <property type="nucleotide sequence ID" value="XM_012912171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D959"/>
    <dbReference type="GeneID" id="24563980"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205970"/>
    <dbReference type="OrthoDB" id="367016at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34242" checksum="FDABFC7FDD726888" modified="2014-09-03" version="1">MAVAEQPRTLREEMHIVSKLLDVQPIVGMYGENKPVLREDVPQREKVADINAKLATLKALIDGEKWIFHDSLVVELPNYQGVNRYVFFKGLLKSMALKLETLYGFLSTATDVPESDLAKKAIELNLVKENEIVEGLDLENLQMFLKVFYNKNSPLFTLLNLFDEYEANLSPRDIWSASTHPFDQFYKDTDGESEGLSTLDESNSRMEIHVPDTVKLPNLSVDVEQPGVVVREHAEAGAVQVNGERAVSGATTHGGDARGVNPTPGVTSTTTTTSESTSLRSGAAEASPKKASYAFEPFAMLLIVMSAAFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D969</accession>
    <name>A0A061D969_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768713.1">
        <property type="nucleotide sequence ID" value="XM_012913259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D969"/>
    <dbReference type="GeneID" id="24565068"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304310"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="147" mass="16592" checksum="371CBDCE1600B357" modified="2014-09-03" version="1">MESQSPMMEEYERAPDESDRKMLRSFCFLSGCAMCVVSFLNALNIFSIGRPALYLLNLVQGIFGFSVMVFEGDEYSSLAPYANVLDVHFKFLSSSLGRALFFILVGIHCSVLTTLSVLYYPLALIWLGVAAFIIANRQRETLPFYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9B4</accession>
    <name>A0A061D9B4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Prenyltransferase and squalene oxidase repeat family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0310410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769324.1">
        <property type="nucleotide sequence ID" value="XM_012913870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9B4"/>
    <dbReference type="STRING" id="5866.A0A061D9B4"/>
    <dbReference type="GeneID" id="24565679"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310410"/>
    <dbReference type="OMA" id="SIMKCWD"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="185"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="493" mass="54070" checksum="DEC53640B464A908" modified="2014-09-03" version="1">MDSIQDRMIRRARDVVSGLESCCASIDAIGAPSREVSTDGTIVLSEDESTIICKDGGELLASYMTYVCRGCDAQEARRLSAEMSESIQAQFLVERDCMALYSSVFARYLMQHLEGDVVSEPPPYDGTPCLSIAVEPLLRYRPARLVLSILSDFSITDGTVRLDSTKHGALFLRRIGTVACESSPLQREVHIRYITKHLTLCGPTRTVPLEHLNCAQPWIVYWSLHSLRILGVDISPYRERAINSLFGCWDKNGGGFGGGRGQIGHLATTYAAICCLKMLNAIPLLDTGKLRSFLFAMKQSDGSFTVHRGGERDVRGLYCAIASAVMADILDDELSEGVAARVAACQGYDGGISGEPLLESHAGYVYCGTAALKLLGRLDCIDVARLRRWCHMRQTPQLGFQGRPHKLVDVCYAFWIGGTLALLNDSADKPFNLSFLMLRAYILCISQCPSGGFRDKPDKAVDLYHTCYALSALDIISQPAGKCRIDLALNIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C2</accession>
    <name>A0A061D9C2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S27a family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0311890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769472.1">
        <property type="nucleotide sequence ID" value="XM_012914018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9C2"/>
    <dbReference type="STRING" id="5866.A0A061D9C2"/>
    <dbReference type="GeneID" id="24565827"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311890"/>
    <dbReference type="OMA" id="AHNNRTY"/>
    <dbReference type="OrthoDB" id="1649877at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001669">
        <property type="entry name" value="PRK00432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS31" evidence="7">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="156" mass="17232" checksum="BCF253D7A2488C88" modified="2014-09-03" version="1">MAGAQVFIKLFNGSTAVFDVNGLETVAELKSKIAEIYNLRNCTQSLWVGIIEAQDATPIAELIGEDNTIDLVQHIDISGGGKKRKKKQYTTPKKIKHKKKKVKLAVLKYYKVEGDKVVRLLKECPSSTCGRGVFMAAHHDRSYCGRCGATYLNAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C6</accession>
    <name>A0A061D9C6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767715.1">
        <property type="nucleotide sequence ID" value="XM_012912261.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D9C6"/>
    <dbReference type="GeneID" id="24564070"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206870"/>
    <dbReference type="OMA" id="ITIDKGP"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1364" mass="151917" checksum="533F249D2A98EA27" modified="2014-09-03" version="1">MRNSAVEGTRHGHDGGNSATKRAPLSQEDNRKRRAKHKKRGGGADADSAGSESAPTSAAVAHGSTPALRHGAEFFANAGAPFLRKLGAYTDAFRKSVSRVYDSDMAVDAALAVTFIPLKEAIEAMPKQTGGTSANNDHHCERFAECVYRDALLCVCYMGKARAANGPYDGLELLTEFLYYHLMRVDYLLENRAMPKGAELLDSQRVIPSSPRTVVRVWESLLSLSLAKDRKLRVAFSTVTYHVMRLACKDEIEIPQKLFTKHADTFVSLLADPNKEMRYRCLQLLEHFQDERVKGEMLKHMADPAAVVRVAAVTFLDVPPTLEEALPVLRKLIARLADVSKDVRSGVYKKLGTVYNVIPVEMCTQIMCYGLSEEAQSMKRAFLYMLSSWISNCGGLVGFLSDMISQTDDVTVLENAISFYMKGTGCLNSFSIRSDKGVGGEGDGAGSDVAGEREAEEDAENIVAYMKRFKTLSPAELVLVNVFYQNHALPEEVKLINMVDVISYAHFVLTTFCNMPDESDQAPQSAVNAMADDDAQFVDAVESNQAAAVHKYASEDCERMKKLYWNMCLVSHALRALLVIAHCHAIEDSYQVALTETFCDKILLHSPVRSNITGLMADVVAQTTLGNNSYSHALPSRWLKGGVTFAATSLLRYVYARKFRLDGKFIGDDPQMEKRHFEVSITRKVLSIISDIKDPFQTSGISNISIRREELERMDLQKIKGFDPTSYSIEHLSLIDAKLREQMEQTWTQQAELENVKSASKEQQQQQEMLQQQEEALLVLLEKQQAFATVIRNCLKERWTRIMAIVESFLGQTQSNCSEDAGLAEFPRAILLPQMAFFCSTVVKWRDQSITDQYCDVLTSKCLGTWCMLNKGRVELWRQLNAFHVALKGALAILEGCLNQAAAEAEFPSDALRRRIEMQTLRCEMYMTTLTDLLVTNVELQQGAAGDDAANVELIEELKDTLWGIVHCSVKSSKYVQSLALRLGCRLLLTEFLRSKQQRVQSPQTAEEKRCSDDITVVRLRGLLELAFVAPAAARHMIADFKFTRSTRYVPITAEDKNIVVSMCALYPTLSYRHLRNFHKVLEQVLMRSVHHALQLELRMVGFARLISFAVQTVLHRSPLYFSLETFAKYFKWLLLITIDKGPILADRGGFMSLIGALISMFVTRNVSSLLDRFGLSRPDGAADDEPRSMSDLCALANPALGLLDLRDMLLLLNYIKSQGGFVKAKANLKVVDDLIELVSNQMRKLATVHTKDLESAEGGVSVIPGEPPQIVFAVDDSTAFSDLVDAYDAYISSLGPRELSALLVEVDDEKPAVVEEAPVASRRMTRPVRGTRASQPDADDEAGEASDASNTFTDDEDEEFVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9P8</accession>
    <name>A0A061D9P8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TUFTELIN-INTERACTING PROTEIN 11-RELATED domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0107530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766641.1">
        <property type="nucleotide sequence ID" value="XM_012911187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9P8"/>
    <dbReference type="STRING" id="5866.A0A061D9P8"/>
    <dbReference type="GeneID" id="24562996"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107530"/>
    <dbReference type="OMA" id="CEQDIIQ"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="756" mass="85888" checksum="683FB27820DCC5C5" modified="2014-09-03" version="1">MYSDSEYDSSLYDAIGEGSYSNRYASGGRRPGGSAFFVKGGTLNMDEDHMTKSGHKGQSTKGAPEEDSDEGVSDTEDASMVYTADTIDRLLADGSERYAKEGHESYEDSSDDDDDDDDDYGVRRASSKMKRVDTGRRHRYENSKRDQGITYDADDVLQPRQIDKMYGKGVKMLKKMGYTGGGLGRDGTGVVAPIDLKAPVDKRGMHKDRDSSTLDIDYMGRVKQPTIRAVPISVNYSNAWRKKKVFRSKHEKQLPASTVKIPEVDQLIKALADKVQWFSEKGRQTYDAVEKAKGALTEAERELQEKESELTEQVEIIEVAEKALPRFMEFFQNVDNAFINLKDTTNVEVIIPVFENFVDRLFLECDADSTPYCYLGVQSICDHYFMRGLHAIYADWDIAKKPDLGARLVQSCLAQVDSYAYSSKTQAYFDQIIEPKLRKFFSEEWNVADTDVGKRCYKGWSSVISLLDGGGFKRRIAFESPLEVKLVNVIHEEKTIHLSHILVHPFLSSIGMGLSERTFVEHFVSAIMRMISKYVVSDVDKCLKPIKSWDRLLRRHDTEKIIQHVVRCLQNELKNVAINPQNQDTSVLQNAFLWMGYIGKGNLSEALCCDFMRRWLKVLKDWVMLPTANYDEVIIWYQGWKSFFPEEVIKTSAMESFLKDALREMDRASRNVLNAPTPQKNRERSPEKCDSKSIMNSVQKIGAMKGVVLIKRRGKTHNGKQVYAFGSASVIFDDCVMVINGNEARPISLYELEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9T5</accession>
    <name>A0A061D9T5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0313630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769647.1">
        <property type="nucleotide sequence ID" value="XM_012914193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9T5"/>
    <dbReference type="STRING" id="5866.A0A061D9T5"/>
    <dbReference type="GeneID" id="24566002"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313630"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="746"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="948" mass="107213" checksum="394F686E1153F254" modified="2014-09-03" version="1">MSLADNNSPLKREDAVSLEDLEHLCSRVQSDPWNLSTYTKGIYIAARLKHEKYLEYLRTQCVKHCVVEDRFWLSWIEDKRRDSSEDELISMYECAVDNEPSAELWVAYARFERKRAASSNNYARIRNLFERGLKAVGLHALDGPLLWSEYRQFEQELLEKCSPADYGSQLERVRSLFFRQLALPLSGLADVLDEYRVWESELPKEHRKPVTEGESIHKQGYDAWERRKCFELKVQSEFDEMLNPGNMNSLWNDYLNFELKCGDNDRISIVYLRALDDLGYERDDLWMRYAAHALGLSEKFALWVCQRSCRHMPRSVNIWINYMQIVSSISSSSAEELVEVFDTAVTAITDTSALISLHITAADCLRRYYPESVEAFRRILLRQEDLLSKMGDLTDTKGTYRLLTYWGRQELRLLMTQKGSPDNYLEVIKKLLQRFVNDGRCWLFVIEGVKSLDACGKCDADFLSSLVAAICGVIAIQVPPDSEVSSAHQVIMWLFDTSMRFVTVGGISESYIDYAQTSGDVEDIKRAHMTVGNQVHIAETRCTGTTLSLNNIILRRDHRRRRQSESFSETSSDSGCCSHRFIKSSCRVRPEGHSAPILSPKLSVREVEFATRATWDGSESADPSIAPAVPPSITMPPPPPSSLIAKFGTQFAVVPGSVTPPDNSPDLKYVSRCVSTMSSAGSLSMLPQPMVSSAGDSYVPGVNKRPAEDLDDIGSVDSERFSRIQLLLSNDNEALKSWLCDSGESNTLWISKVDGDLDESFIRSIFTSAKGFKSIRLLPSRGSCYVEFDSYDNAVRAKAIASSSGLDREPYDCEVSKSCNTLYEDKVLFVKRISDIVALNKPRITRVLQQFFSELGHEPANIRFPSIGFDCDGEDSHMRVPNYCYVDFKEEDSARSIINRLLSRSGTLSCSMGDVAFDVSPSTAMFRKRHRARGSCKETDSDCMYSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9X4</accession>
    <name>A0A061D9X4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UEV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766731.1">
        <property type="nucleotide sequence ID" value="XM_012911277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9X4"/>
    <dbReference type="STRING" id="5866.A0A061D9X4"/>
    <dbReference type="GeneID" id="24563086"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108430"/>
    <dbReference type="OMA" id="MIECTAS"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UEV" evidence="2">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="378" mass="42765" checksum="EBF69DD9444677C5" modified="2014-09-03" version="1">MASRRSTDMYATGVQKLQLGDVLKRNFKNALIVEADLRNTLGKYSGLTPSLHYGSAGVLINLRGTIPFRFQNVVYNCPIRIALNPEYPLSPPYITVQPTEQIKIVQKHPCVLKNGDVVIRYLREWNPRATLVEALRYVQDEFDRAPPIYAVELRRSATLPAAASQGSGIATPLRHSATSSEGSMTPRGASDEGSLDAELESIRSRITANVRDMRAQLIKEYQYDVGKYDIHRLIMLDWVPTCVNIAKYIKEQYAEREKLNRARADCDKQLHTLEDIDDYFTQVIAALTKMQTPTGEADKSVSSDASEPNYNLEFDSQRDERLCRAVASEAAANEMMELLQATYKRKQISTKNYIYYVRLISNEKFRAMHARKAAAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA05</accession>
    <name>A0A061DA05_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769529.1">
        <property type="nucleotide sequence ID" value="XM_012914075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA05"/>
    <dbReference type="GeneID" id="24565884"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312460"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="173" mass="18807" checksum="4BFDA1DB9665E963" modified="2014-09-03" version="1">MESDKARQPCWSEKAEQEIAELVERPNAEDDHDADDDDDEGDGGDEVRSGGGGSSHLTAQVIGHQRNQGYLAYEEIADVAAHREAEDAQVEQDDGDDDGNDDGGDGGVGRGGRTDGRNGRRKNRGFAEFRLIFTFLQTTFTSTFVLVAFTFGWTIESSALVKFLASLAHPDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA80</accession>
    <name>A0A061DA80_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein L7A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0313500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769634.1">
        <property type="nucleotide sequence ID" value="XM_012914180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA80"/>
    <dbReference type="STRING" id="5866.A0A061DA80"/>
    <dbReference type="GeneID" id="24565989"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313500"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="128" mass="13837" checksum="DB11C84B019E6649" modified="2014-09-03" version="1">MSAEGSDSKAYPLATEEMNGVLLDLVQQASNYKQLKKGANEATKALNRGLAEIIVLAADAEPLEIILHLPLVCEDKNIPYIFVKSKIALGRACGVSRPVVSCAIISREGSPLNQQIVEAKDHIERLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA92</accession>
    <name>A0A061DA92_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766846.1">
        <property type="nucleotide sequence ID" value="XM_012911392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA92"/>
    <dbReference type="STRING" id="5866.A0A061DA92"/>
    <dbReference type="GeneID" id="24563201"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109580"/>
    <dbReference type="OrthoDB" id="366863at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="347" mass="37753" checksum="EDCE213A3B6553A8" modified="2014-09-03" version="1">MAAAGKATNTCGCDTKFPKDHVKGICSDTDCPKCYSCCGPGCTGCITLCKDVEDGVCKCSLCGCECRNDEGVKGSTKKCSESSCQRCKDKCQNVEVGGRCICYLCNCGCNGVNCQCCKRCNPVTTCPGKGKCDTEEKHGDKCPKGQCKQKPGDCSTVNCMCDDMGVRAKHNGECVCKCRCEQKCPRILCADKRGKESTGKPGTCCKSNSDCTCECKCNCNAYGKYYCKDHKANSKGCDISKCNIIFYGIGQCRFKCTNCGRLCDQDRCMNWIRVIVIGLIILASLFVLRAIFPEKFRAIMTKIRATFASSPVHSGRSLNTLVGDTIPEETNIDRYPAFRPRIYAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAC4</accession>
    <name>A0A061DAC4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766871.1">
        <property type="nucleotide sequence ID" value="XM_012911417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAC4"/>
    <dbReference type="GeneID" id="24563226"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109830"/>
    <dbReference type="OMA" id="ENKRITH"/>
    <dbReference type="OrthoDB" id="365045at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600737" evidence="2">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="234" mass="26153" checksum="9C71533E56F9BFE0" modified="2014-09-03" version="1">MYAVLALFALCVRIASGSILLFGPVRPNTLACTTDYYGIGAEPQVPEKQLEKVKDFPQVTIAPVIETAFYTGYANQLSECVMRLRKEYLELNQDLVYPSVLHRLSLFVAKDYVRAHTAMADLHMLKMLHFSQRLLLGYSNSILTEPPHQTVEIRAEKYCNACVYVDVSEKLGRYRTKRALKLSAEVKRLVANINNIPSVKVTGKISLLVDAFCAPSLVLIAGGPIVLFGFHLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAD9</accession>
    <name>A0A061DAD9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769128.1">
        <property type="nucleotide sequence ID" value="XM_012913674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAD9"/>
    <dbReference type="GeneID" id="24565483"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308460"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="127" mass="14564" checksum="783301FA556791EF" modified="2014-09-03" version="1">MRCNTFKECVKIIVTGFFRFLKLLNFSHFMLTADVRLGRIENLEKRTDISCISLVNSLCYQFFQSFGQLLKTITISTTPHLYQPVDGLPEVLRAVKSRDHDVIDRMELHMQFEAADPDSCENAVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI1</accession>
    <name>A0A061DAI1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Surp module domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0308900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769173.1">
        <property type="nucleotide sequence ID" value="XM_012913719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI1"/>
    <dbReference type="STRING" id="5866.A0A061DAI1"/>
    <dbReference type="GeneID" id="24565528"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308900"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="7">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="7">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="501" mass="56361" checksum="2B46B5D3C4F49988" modified="2014-09-03" version="1">MSESAAEVIFPPKYVRTIIDKTAQFVAKNGDQFEQRIRAEQGEGAAGSAAKFAFLNPNNAYHAYYRLKLTELKSGIDVEIKPSIPQAILDRRKKLELKNEFKERLLALTDFGASGADDEIDEPEKDAFTFTQPFVAAMDMDIIKATATFVARNGQRFLVELAKREKSNPQFDFLSPSHCLFGFFTSLTESYTKCLLPTKPQIEKLNTVAKDKVAYLRKCQKRADWDARQQAKTASEEMRKAEERMEMQSIDWHTFFIAETITFTPVGCQMPSKITVLLQNEEGLPPPIDFTQPGAAMLLMTRNPRTAATERNSGEQLTSVIPLDADQINPEVAVVVDDEEEKTEDPSTADITAPEPQEADNAVAVETVPTVSKFSDAPESYKRRVARDNDVSIDGDEIIKVKKSYTRKSKAQTAVEMQRCPITGQMIPATEMSAHLKILLLDPKWKHQKERFIEKAMKESAFAPLEGNLRVNSPNYVQTSRGTLHHSWRAGPTFLVRQTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI9</accession>
    <name>A0A061DAI9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769754.1">
        <property type="nucleotide sequence ID" value="XM_012914300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI9"/>
    <dbReference type="GeneID" id="24566109"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400600"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595617" evidence="1">
        <location>
            <begin position="18"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="955" mass="105843" checksum="619FB08B5F4A1843" modified="2014-09-03" version="1">MMRILILVVAHFVVAVGANLPVTKNNRIINFLNHEIPENGKILVHLVYLSKHNALEIICPRAKGEYSYDLLPNRSESIPSGDIYVYATIDGVYQKVNINDVVRFESADNQPKLRQQFGMTRMLLNQGLSSDIVRYDVESFDVHCAPADNADGVHKGLGACLSSASLNEEERSRCKYSKKGSPMLGIVRVSLSSVPRAYTGCGSMSAPFLLDGWGKVSTGTSCVVDVMETPDVGFYCKGRIEPANCPFSLYYGNNDMLSRMPFKVDVSSSGYEGGTMLAMRYDRSSITSPFSGRCRCIDKATNTVTAVIEITSKERHVCDLSAKLTQHLSRPIAGDWCDVVLYPGSSLEILFPVTANELSSEVREALLGGDNVSGPISTFMPAKPDVEALTRTAGENTLVYGTVPLISVVDPKVVEVDSALLSDGVVYIQHKVSEAEPADRDPASFYFRCLHKGGSDHTSVTSTIKVTIAYGSPNESYAGDAAADALNNPARVSQYFTDMADTARIQCNSGEHMVPKNCASLTFNANRTAVIPLPRGMRSYSYRNIDNLRDFKVEESFTNPFSLHCSCINDDGVETWRVTFNQIPQKYTMKGQSPDIKSMIMVPRIKSYDVGGMLRHDKIVIPVSDVYNEQKVLRVSAGTLNGLLCTPPKGMTNFQSVPLPGDVVPFKSPVDSNLQGDHFDNDTVMLRQDEDVSKSYATWFPYNDSNEFVNLVKTGDEYTLTTADLNTVMISKGGFSIGYNVDHESDLIDRSDLTIRYPLGSIVISRYGRTDVTLHYVCGSISPPISLEQDRWDETKRQHAGESPEMEERSMVIWEIAKVHVPTTDPYVQGCGIPSESDGLFRPDTVPLTDDSGKTIGCVVNLKTAKVAGFYCPLPYRTDPPDCQLVLRKGPQARLLKKVFNRLRVYRSTHFHLFERRNVFFVKDHLKREKKLYTYVCNCETITGVVVSTIKVQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAT4</accession>
    <name>A0A061DAT4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0401600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769854.1">
        <property type="nucleotide sequence ID" value="XM_012914400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAT4"/>
    <dbReference type="GeneID" id="24566209"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401600"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="146" mass="16257" checksum="E75B9A8207012A7D" modified="2014-09-03" version="1">MRDLRHLVAVVVTDPYLQGCGVTYGSAELFKPETPKLYNAEGQEIGCKIDLQAARKAAFYCPVPYLLDPPGCFNQVYVEDEVKSLSDISQSLVASHSNHFVTLKFNSELVGPGETLSQTPPLECRCVTIKGIVLSTLQIENYYYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ2</accession>
    <name>A0A061DAZ2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0403190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770017.1">
        <property type="nucleotide sequence ID" value="XM_012914563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAZ2"/>
    <dbReference type="GeneID" id="24566372"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403190"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="506" mass="54440" checksum="33560C4799F494F8" modified="2014-09-03" version="1">MTNSKSTEPAAATSAPKLIYNSLGQSLYNLVSFIEGYDQQVLSMCMRAFELTLGFSQSQLSTLATVSTMSRMGCCLIWGLLADKHHSNHVLGGGLLVMGMASILLSSASRYNVIVFLRFLHGFGFACVYPVQQKIVADSTSSNETKVTNGAPGQSMAGGTATPEKPKKSEGSKIFTRLQSLNCIGRLLCAVITTLIARKVLLGYYGWRTSYVVLGYIWTLFGVAIIFGMEGNKPSLSNGVNGDQGPSTSEDTTFNKLLEGAAKSVFMTATTWILIFTIFIAEAPMCAFNYMTIYLQYLGVSDTMAGVAVAVTLIGGAAGSAAGGMIIDTIAKADNVYSELGSGAAVMVVRLVVCLLFFLGKAPSGKLLWYHYVELATLGGTLVTLGGVDRAVMKKSINDMYQGTASAMVRTISGIASSVVFFQVSAYLTEKVFGYVPSRESFDTMDAAVKERNAEALRKSMMYIILAGTSINTLCYIALFFTYENDKDKLKRTDATQRESNHVTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB05</accession>
    <name>A0A061DB05_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0402180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769914.1">
        <property type="nucleotide sequence ID" value="XM_012914460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB05"/>
    <dbReference type="STRING" id="5866.A0A061DB05"/>
    <dbReference type="GeneID" id="24566269"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402180"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="64"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="248"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR97728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="709" mass="80171" checksum="2CD3576A68A538E4" modified="2014-09-03" version="1">MVLFHVALVLTDATPRKAAERATENDDADPKINPFTKTPYSQRYYDILEKRRQLPAWGARKNFVKLLRRNQVLILAGDTGSGKTTQIAQFVVDANLNDGLQVAVTQPRRVAAMSVAARVANEMDVKLGETVGYCIRFEDRTSKNTVIKFMTDGMLLREAINDPMLSSYGVIILDEAHERTIATDVLFGLIKEVAASRENLKIVVMSATMDGDKFQAYFNGADMLTIPGRTFPVDIYYTAETQRDYLDAVYTAVITIHRDEPDGDILVFLTGEDEIRKLEDRFHPVTNMYKKKLCVVPLYGSMEPAEQAKVFEPVEGRKCVLATNIAETSLTIEGIVYVVDTGYAKQNVYNPRARVESLLVAPISQASATQRAGRAGRTRPGKCFRLYTEATYNELIPQTFPEILRSNIATVVLNLKKLGIDDLVHFDFMDPPAPETMMRALEELNYLGALDDDGELTPTGDLMGEFPLDPQMSKVIVSSPKFNCTRDVVAVCAMLSVPNLMTKRRDKYDRFNKYASSLVQRVTHDTSDHITFLRIFNTYQAMLHKAKEKLSEFFLLTRVNAKAMEAATRIFDQLMNLAHKRLKQPAATVSSQGNTEDDVLKCLCTGFFQQVAVNPVGELITMKDNQVVHLHPSSVVTHADWAIFHQVVHTSRTYIRTVSEVYPSWLFEASLEYFNPAEVPDRHVRERLKADLRFYKEELDNAKKNKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB21</accession>
    <name>A0A061DB21_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0310850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769368.1">
        <property type="nucleotide sequence ID" value="XM_012913914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB21"/>
    <dbReference type="GeneID" id="24565723"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310850"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="136" mass="15206" checksum="1C4326DB0EFE4EE9" modified="2014-09-03" version="1">MQVCGVTSSSDKFFKPETPKLYDADGREIGCKIDIHTAEEAAFYCPAPYVLDPPNCFNQVYVDGEVKHLGDVSQSLVASHSNHFVVIKFDSELVGRGETLRQTPPLECHCVTTKGVVLSTIQIENYYAKEYLTDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB59</accession>
    <name>A0A061DB59_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">histone acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0404040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770102.1">
        <property type="nucleotide sequence ID" value="XM_012914648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB59"/>
    <dbReference type="STRING" id="5866.A0A061DB59"/>
    <dbReference type="GeneID" id="24566457"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404040"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="376" mass="42204" checksum="9D7331340B66D2AE" modified="2014-09-03" version="1">MFPIRYDPRFYDAACRVNPTAPLPNEAWGASDMFGIGMFLPMSVVRANSDVSQVTCCEGSDSSSSSGCSSRRASVGSSDSSVDDEPPTNEGDKNEDAEPASAGSDTGSLKASGCDCILNDATYDRENDEFLVGFLTIWINRNAFSPMVSDNDYFLLENFYQDMIYPFMMTCNRIVDGTPTWPNFKMLSADSYRFLFSTLYCNSELLDFLSGFNLKECKTVYVLSAGVTMGLRSRMLGSHLILFTQCMMYYCCYNVFLYNGQMFHCNVESRKPVLSALDLFLSRGDAGDSLELDDVLESEVAPYRLSPSSILKKFHYCDAMPITIYLHVIDYNARACSMYRRTNFICVVRIDDFYAINGSHYSANLFAYYLCPPCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBC1</accession>
    <name>A0A061DBC1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0404810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770182.1">
        <property type="nucleotide sequence ID" value="XM_012914728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBC1"/>
    <dbReference type="STRING" id="5866.A0A061DBC1"/>
    <dbReference type="GeneID" id="24566537"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404810"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404810"/>
    <dbReference type="OMA" id="AAECKQN"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="296" mass="34489" checksum="4A5E2DF3D6DB7A14" modified="2014-09-03" version="1">MTEDSALIERIKNVSLDGPMGKLNESQRQTVEKLQRLQKSRDELDVAYNKELNELRAKYDLLFQPIYEEREKVLTAPSGNEKGTPALPKFWLTAMKNNNTLRSIIEFRDEAVLAYLSDVKAEFLEPLKQESFRISMTFDENPYFSNKVLTKQYTMKVIDGEVEALLQGTEATEINWYPDKDVTRQTVTKIQRHKRTKETRTKTEVEDQPSFFRFFTTQEVPTNEALSRMTKQEIAELEMYVEEDYDIGIVIRDKLIPEAIYWYLGVAEDDDMDEDDDDDEDAESYGNSDSNFSESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBC9</accession>
    <name>A0A061DBC9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase CHFR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0404910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CHFR family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770192.1">
        <property type="nucleotide sequence ID" value="XM_012914738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBC9"/>
    <dbReference type="STRING" id="5866.A0A061DBC9"/>
    <dbReference type="GeneID" id="24566547"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404910"/>
    <dbReference type="OMA" id="PFFDDVC"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="729"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR98006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="865" mass="94925" checksum="BC1C629DA590D0ED" modified="2014-09-03" version="1">MESEPIPLGATGKDSIIEASVGGNALDGVIELEEKEVESPASEGVISTSSLKRRSLGAGMELHQKRQALPDSNMGLREVDPTDVGDISQDECPASAGAPPPSDLGPSSGFVDPLGRYPGGPEMSDRPSVMFANINGEFSATTPPLFASAQLLSEPLVPVDHLSLCVNRQSMNDVHGSAVARDSSVCVDHSSIGTYGSSCATQGTSRERGDCATHPCTIDAFDDNVSNATSNSLPDVPMGVSRIDEVHPAPYDDNMDASPDIDNLDLVSAPCGGFEMLESYTATNDYGCISQISNPVCMNHLEDTAILDTMLGPTRSSQDSVSNLIGSAVDTHREVDSMPSLEIRRLSNGSVNLASDCGDVKRQIVVDENLTNTILKDLICSICLEYFYFPVTLSCGHTFCRYCIGHLRLAGKLCPLCRKEVGRPPSVNTIMWNLVKALKIRKRPTLPEAPRDTSFEEEKAWWDEHCLKPFMSLPLFLRIMFGDIVQTPPFFDDVCTCVVDFFDKHASWSKAKWVFTVEDSRVLRRLVGFDSEDMDATSTRLQLWVENYLSNNPHLCCSTEEPYPFVLKVYSDINHKIDGISFNAMNIHHRLPWDAGRHVKSLLHLPHSSVSLSHLIFVPCGQGHVGLLDCGSTIGTMIKLQGQRTLQDGDRIHVGDKHEVDVILSSTDPDMSYDHLRWDPVRKEVVDLTAPELVNVDPSSLESIDCPLLLRIYADAQEEREVWTNPKGIILGRGPQTQSAFKKLSITTQNGYISREHCLIYYDGSRPSGQRWILRDMSTLGTFLKVKPFQQPIPIETGFIFKVGQCKVEVCSATDGLHRRAPNSPAALILSQLIHNHFSNVAATIPPPQAPDTNVVQSNNSQPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBE1</accession>
    <name>A0A061DBE1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767246.1">
        <property type="nucleotide sequence ID" value="XM_012911792.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBE1"/>
    <dbReference type="GeneID" id="24563601"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202170"/>
    <dbReference type="OMA" id="WALSWSN"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="627"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1491"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1590"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1493"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1642" mass="176999" checksum="21705F46E3323658" modified="2014-09-03" version="1">MEPGNGALLAFQIPESLDYRGLLRPPGAEEAGRLDASTAPDPDGWTAEDVDAALGPVMAATSRAPHECLNLLTTDTFCCAFNLARHFPNLERARQLAFSQTLAALCSRAHDVLEKVPPTPYFSSAEAAANRSYLDLERKIAGSRVSGASQHGAMLYNGADTALMVKHSDMGQVLRSLCHLCVFLVCTTFRCTVASSKEGEKSALLSDLAPGKKGKSARGGGARRRKAGDDGNVNLVALELLADSLLQLARSAIRVPFSGEYGGIGRPDSPLLRMLLDTLLLALSTPAMGPATDKLTDALSRLIRIHFEIMRDCMQAAKARRMLAGRVPQGGGPEAAAAADEPGDTPVDSARTDDSTAGRHDSSGVDNDWLVTLSEELKKSHTVNVADALVLLDGSEIPAAVVNELLVLVRERFVLQASGGTVQMMSSLIQLEYTNVGVFIERMARRLPEAVLRSLEELRQLLDVPCYNLRKSIMESVKLMVIMAKGEGDDAPADGAGDYAASSSKAALCARHRETMLQLLLARQCDAYMYARASLLKAFQEILEAGALPIRWLVTTASFAISRLWDRGSQVRQRALSLLTTLILDATTKRFMLPLNAAGLKHDLGIIHAQMAKVDTILSYVARGGSSAAEGEETPEQAGHGPRAEDGAVAPDEAQSDPAEPSDAAKPAERSDSAEPSDSANPAERSDPAEPSDAAKPDERSDPAEPSDAPVTTPNAQAGEQECQQLLRELNEELGESISWDDRRDLDTLRAKLEVAAEMYTDVHEIATKVESSIRVCGDLLKSSVEGDQRAAIRYLATCHLMGVQPATELLPRVWALAWSNNQNVVDAVLHEFRNLYFSYGDEAAIANSLVELLSSSSLTSFASIEKIFEVNLARDQPYFANLDRVMVALLRIALAPNHQLGRDATPRVALGVMRLLINSSLRSKSPLAAAIRNFDEKRLSAIRGLLQLSAGHSCTIFGEVCSILAGATPSPLMEDVAAHILKLFVGMFGSTDNSWFRMAQCVVDVTFTHCKFAESVWSQTLGGMMERLGVPGIGSGADKSSLGAVPGGPPSEALPSAESDTATAPATSTATVRQLAQVIFLSGHVAIRTLISMDRLQTDLKSARADLEALDEGNLANDASSQMGVASSDEQERDLFEQLCDKSIVCENLLGGPVRSLIVACLRNPLHFVTHGSSGGHHWSRGDLSEPSAVPQQALAAAQREVSILKTCAAIALCKMAAVSKRFCRSLFQPDDASRPACSVLEVIISLLLNKRLAPGADSGALIGSLRNYYYLSEPVASELRATLLISYGDLLCRHPNLLEPWNDEVWPILLDRDDRVRETAVLVFTHLVMNDMVKPRGKLVDAMMFLTLDTHSKVSDCARTFFHEVDRKNANTIYNCFPEMVATLARNRRRQSVKRNLKVLQMLLKFIRRDRQAESIVEKVCFRLQATAPSDRPAIVVYAHVLLGLCQDERCMAKLIASMPLINRVLLESDILLAALLIICKRARSSNLGRRAGDAERPGDGGDTTAPGALAVAGGAAGESASIKDQAEELSSRLHSLFGERRSSHVTHIAANAESIVAAAEKPGPGEDDAACAENLFIRNFGWVSAGTDRDLSDNEPEPPQAGHSELLAHVKQELDVAVGSRLVERASEGTKRKRSAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBV4</accession>
    <name>A0A061DBV4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET AND MYND DOMAIN CONTAINING, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768550.1">
        <property type="nucleotide sequence ID" value="XM_012913096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBV4"/>
    <dbReference type="STRING" id="5866.A0A061DBV4"/>
    <dbReference type="GeneID" id="24564905"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302680"/>
    <dbReference type="OMA" id="HICCREL"/>
    <dbReference type="OrthoDB" id="360916at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="803" mass="89848" checksum="071D6E34A19FD411" modified="2014-09-03" version="1">MRRFESHHADRFCSLDYYLRLLSKVTLVSVEIEIVNPLNKQIRELLQDQPVRCAIGENGFDEPSGLDSTCPEVSDWDIELPDLLGVGIYESLSRLNHSCSPNLEFEYGCDNLARVRVLRPVSAGEQATIAYIDEQAPLEERRKELWNNYGFVCRCSKCLSDEEAEKTIDHHDDPGVSFETFLDALVDERVLDLKYNGVLPALIASLKRSCWFFESTLFGPRSKAASIFLKASLHKESYRKCGVEPIFKPHETQKYLQKRQTIVHFFKRAKAAPPDQKPGASNSMDYLKRTMDYMYNVPNGDGEHTDAFCNRIITGDELMFSESEAVTGSDKSDADIADSDIAGNTTVGPNTELSKVKCDDGSNGGTSCVESSSGLDYEGDMSQDSSVTGGTQETWEDSDLLKKRRMGPSDAFVECTTATQTDYIPNATVKTCTEAHIGGYKDTHRSTDASSPTADLKNDSNSESCNTLGPSCPAGDASTGSVDASTDSAAAEKSERSHFCNSSVIMYGRSNLMAPCYYAIRHLLSKPMSELLAYPEHFRTRYTFVLWQNPCLQHLCGREVRFAYLNNEITAAKVIEILSNKKSKCCIVEDIDVLPEELQLVIAKHMLKHDRPFFFLSSQINRVSPVLRGIAFNFRVPPMNVDMLVDKALSQQLCPGLFLGMARKNIIECANRARDDVVALYCTLVSLQQKKTVSSRRDSLPLRRIVHCIAFQEKTMRTIMFIKNSVSGLASAYNRDPTTFWLEFLDEVNAVGRAELLNVREKFYHLIAQKSTLLASMGDPRVTLESTFLEMMDMVNGTCKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC37</accession>
    <name>A0A061DC37_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767491.1">
        <property type="nucleotide sequence ID" value="XM_012912037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC37"/>
    <dbReference type="STRING" id="5866.A0A061DC37"/>
    <dbReference type="GeneID" id="24563846"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204630"/>
    <dbReference type="OMA" id="TIKLIHH"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-2 central" evidence="2">
        <location>
            <begin position="388"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-2 C-terminal" evidence="1">
        <location>
            <begin position="773"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1188" mass="133183" checksum="BE9D71FB8E2D6CBF" modified="2014-09-03" version="1">MAEAEFTATVVTLCRQTLSGDRAVISAAEENLKALLQPNGVHIRHRMQCLFRLILIPSPLILQPTAIADNDLKVVSPELQLWVTICLKNFIRNNFDTPESHGGLSDDLRHLLRCLLVVAVLNHSRIGLDKNVFRQLEETLHMLSEYDFPHNMDFAILFMEYCHLSDVAPAVVANAFSQRVHKEASLRTQVNMGMNPSVENSQSLARSLEEAKSTAHLAYGESCAALVASYSQIHQSLESYSTALTVGDLGILGRAYGGLYRTIVSGCESMCQVLKGVTLSDLDLGKFLQAAAYLFPKERLLIHSVNSSTSGSEMKHDKGDPLMYFDDRVLYKDPALWQMSGATLPELGIEGQWVMVTLRPGSLINEATIDVDYFRRKSHTLGVFKRLMKKYKTSVYGDAILSELKIVLTLSESMLLYVFKACLCKLREYVPMMSVAGSTNCLSRVVLDLLESITSITKILTYIHVIDMPECCEDNLDVYLGGMLELLRFSDPVILQVDQSGIVRKLKVAICKLLRYYGERYQEAFRPFVFQCIDDTVALCRALSQQSEDDRLCSAILEFLAASASTHWNPHGGRNSPFTDGDYLADMIRSIVLPNIGFRECDLFLIDDCPQEFVQRELDTGTGHSRRFSAISLLKKLVNTYGQMVQYILNQFALNVSGVNDYKIKELYLQLIICSNFKVNDGFQVHAYFSEHLRGDFLRESQSLINEQANVLIVMAIMKFLFTFKKQIPVNDLSSLVAPVSAFLQHQNDAVRFLAAETLNRILPLVRDYKAQLKQTLLQALGCILQRMRSEAPNEFYVRCAMRIFLYLRQDVLESGFVMLDIIVELIKKASDNPVNPIYNHYLFECLATLLRIHLAAGSMDAVARIEDGLIPTIAIIIQQDTHPFVPYGLQILYILLRSAQQPGSTYMQLFSHLTCIDTWRASTANAQGAAKLLVCYFERHALFEKEIVANIERILSIFHFCLTHRKLSLVALDLFNGLVRYLPVAFYSKFLASIVTVMLSFIHKMKTGDCIPRVVTSMALLATSLHLQQFSPGFVQTLETIQSGICRNFFQVVYVPNARKVLALESKRVLMVGTAIMLGSPVVQVSADIFTLLANFLGELIQGQSLKAAPTPVEPDEMEDLMQDLEFDVSFVRLRSVEDPANRGGARLLDPSVNVEHLVRGSLRPIASIIQQLPPGGGAQSLLNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCD0</accession>
    <name>A0A061DCD0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fumarate hydratase</fullName>
            <ecNumber evidence="5">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0206380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767666.1">
        <property type="nucleotide sequence ID" value="XM_012912212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCD0"/>
    <dbReference type="STRING" id="5866.A0A061DCD0"/>
    <dbReference type="GeneID" id="24564021"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206380"/>
    <dbReference type="OMA" id="SMYDEKN"/>
    <dbReference type="OrthoDB" id="411469at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="entry name" value="Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051208">
        <property type="entry name" value="Class-I_Fumarase/Tartrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389:SF0">
        <property type="entry name" value="FUMARATE HYDRATASE CLASS I, AEROBIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389">
        <property type="entry name" value="FUMARATE HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="FumA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic" evidence="12">
        <location>
            <begin position="116"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase beta-type catalytic" evidence="13">
        <location>
            <begin position="411"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="618" mass="67423" checksum="8CED1042ACB189AF" modified="2014-09-03" version="1">MLRQLSLTNAVKNVGRRWNARNKLLRMYGNPCQGCKCFGSQATTPCAPKPTQAAAAPEFDLRFVDPLKKAGCSEGYEFERLDDLSSLIKVVDSSVPSITDATPVKMLTIPPRVIEELTERAFVEIMHFLRADHLKQLRGILDDAEASNNDRFVAMQLLKNACVASGGVLPGCQDTGTAIVIGKRGNRVFTEGDEAAIAKGVYNAYVQRKFRYSQMSPLSMFEEVSTKCNLPAQIELYAKEGDAYNFLFIAKGGGSANKTFLYQQTKAVLNPDVLLNFLVDQIKTIGTSACPPYHLAVVIGGLSAEMTLKTVKLASCKYLDGLPKEGGSFGQAFRDVKLESEILDMTRNLGIGAQFGGKYFCHDVRVVRLPRHGASCPIGRPLVFRTHICCPGIGVSCSADRQIMAKIDASGVYLEKLEHDPARFLPAIEEANGAEEVIVNLDAGMDKVLEQIRKYPTKQRLLLNGTMIVARDIAHARLSQILKETGDLPDYAKQYPIYYAGPAKRPDGLVSGSFGPTTAGRMDSYAAMFMEKQASLITLAKGNRSRAFANACKKYGGVYLGSVGGPAALIAKDCITSVEVIDFPELGMEAVHKITVKNFPAFVVVDAQGNDFYKEWCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ6</accession>
    <name>A0A061DCJ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor Tu GTP binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0207650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767796.1">
        <property type="nucleotide sequence ID" value="XM_012912342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ6"/>
    <dbReference type="STRING" id="5866.A0A061DCJ6"/>
    <dbReference type="GeneID" id="24564151"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207650"/>
    <dbReference type="OMA" id="GRITQKL"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF5">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="429"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="980" mass="105480" checksum="E79C4AA9D0009A04" modified="2014-09-03" version="1">MALSRARGILSRQGTPRLDSGAVDLKDYLRKPKEFPETPGHTGSSKSALYRSIKKFVVFPQGKGGQATAALVGPAAARNALSAIKPASRVSEKTRRTVNLTALNSAKASSNASLAAALRHGSNAPCTGHQNADPATKCGAASHSDAQYAVDEEVEYQLLRYEGVDPQLMSSVKEVRELLLSDASAFGAAAPHAIQPPVANSKHYMISPAHMSFLLHRIKALTGRDTCSKEELLQRVLSFLETGSIETAGDTGATWSYKASNRTLISDKSLDDDLQSLLSSIQSRASAASSQPPASAAAAESSATNANHSAPRDTTNSAYRADASDSKICAQLAQLDYSRAAERSGSNRKAVTSNQVTVQRLTADTIASYLNVDANKIISLVEELDCDPAHLSVDEASFIVEELGIPFRVDFAESREGVTISRATKMEVKRSLVVTIMGHVDHGKTTLLDTLQRSNIAAGESGRITQKLGAFKIQLERGPLVFVDTPGHAAFGRMRDRGVRCADVVILVVAADDGVMPQTREAIELIRRNDLPYVVAVNKIDIDAGLHVRGMLEDCGLDLSDVPVVYISAKSGKNVDELAGALFDLGERLNLTVDASMPGAAYVFETERHPTWGDCLRTIVRSGVLREGDWLVCGESYGKVKRMFDPNGRPVKQAFPSDIVQVSWPYSTPCAGLFVQQRESQAKAQKLAALAKRRSANASHRLTAAPSAGTATTAAPTVVGDGGRRPTKGERLDAKPIPELCVVLRCGDQGGLDAVLEWIAEFNERKRADCDVSHLKDRGYVETHTTDVTPLLSSWNPIRVVSSNVGAFNRSDSQFVEAGNVAFLGFSTPPPKGIPVPELTRTHNVVYELFNDIERMFDFYFGPTYVLKQEASMSVTQVGSISLKGVGKRQAVGTSVLSGTVRQGNLCMLIREGKVLARELAIASMQSSRKNATELLKGDNNNCLVFRNCDTEAKLGDEIVSYTKEPLPPLFGVVSESILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL0</accession>
    <name>A0A061DCL0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768955.1">
        <property type="nucleotide sequence ID" value="XM_012913501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCL0"/>
    <dbReference type="STRING" id="5866.A0A061DCL0"/>
    <dbReference type="GeneID" id="24565310"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306730"/>
    <dbReference type="OMA" id="KSATRWE"/>
    <dbReference type="OrthoDB" id="366061at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="433" mass="46339" checksum="E464D1A40322F449" modified="2014-09-03" version="1">MALNSEEGRPAVGEQEDSGLHGDSRAGVVAGAPAVDGSGLSSESMGEQIAASSREQPAKSATRWEDAVLATQTAVTEHLESFKVKAETPIPASTMPCILDENTKVVGETQEGQQGPAGQGPGAVLFDSYYQLPPKELIALAASATRSCSLFSFRKDERRSARRAKADDPRSKNSVGHEDGRHGNLIPYEPLLEPMNIPGHDQPLEPENGHGKPHHSHGHEQRSGGANHPKHPGRQREHTHPKGGAHMPGDRKPKHTDGQPLPSKQNTKAKGPAGGAGRWSAPKPTDGIFSLGSLRPESPSATPNTANDSHAMSFKNLSQMVHDLHIKKTVSLRHSDDVMNMTPQDVSNFTFIDEESHIPLKSSQFSKFFSVVGQQHKAGRFPVAQATIGAEQARLAAQGEGSDIPGMNVAGDAKNRERASQLLQQMLARKTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD41</accession>
    <name>A0A061DD41_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768116.1">
        <property type="nucleotide sequence ID" value="XM_012912662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD41"/>
    <dbReference type="GeneID" id="24564471"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210800"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="80" mass="8863" checksum="88D04AD189008D1D" modified="2014-09-03" version="1">MAHWTHGSSATLLNMYMLASQFKSFSMYVGAPKFPLSINAEQICMGTANTDVPQEVFTTSQTRDNSSMSCTLHVRILSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB5</accession>
    <name>A0A061DDB5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768316.1">
        <property type="nucleotide sequence ID" value="XM_012912862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDB5"/>
    <dbReference type="GeneID" id="24564671"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300350"/>
    <dbReference type="OMA" id="NNSIYPQ"/>
    <dbReference type="OrthoDB" id="427543at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="265" mass="30605" checksum="703C6D1F6CC18E7C" modified="2014-09-03" version="1">MPRGGHRGCLFAVSGRALTAFGRRRRRGLYHHCTNELFRPAWGPVRQPALLMDAQLPNWASDTLSPAEKLPPKPQYSRDARSAWPQERSSFLLNMYRRNVKRYFHPAAAANDDHVRNYIYEVLEPSYRKCFSGIGVDFMRQSSNPARHIADLVKDVNAVSAPTLDLRYREEAAPRFKRMESLVRQSEAWRSVAPMQEASANPFPHVNESASLVRNLGVADVLHTKSNHRLARRAHPKWYTARYRKFMDKKRLQEKLRQLKIETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB7</accession>
    <name>A0A061DDB7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0300400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768321.1">
        <property type="nucleotide sequence ID" value="XM_012912867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDB7"/>
    <dbReference type="GeneID" id="24564676"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300400"/>
    <dbReference type="OMA" id="IMCCLAN"/>
    <dbReference type="OrthoDB" id="365053at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="451" mass="50720" checksum="1343C3EC6A585708" modified="2014-09-03" version="1">MRSTWLNLRKAVTEINNFTQLLYSESDDDGEQPQPASHLSEDVHRLSYASATSDNQQEHDQSGLESAEQRMRMINTLGKASGDKNDDVLGDFTAQLISQYEHGLQQGGGTFDKSPLAKAMPSRDSIRSSAFQDVDRMKIFHFGDLENESADSASSVAVSGRLYILYKMCLTLESLWMDIEGRVRDATGSPMFVPPMQRPSCWQKCHSVHNEHTEKILSWLERSLHTMAVLSRTMGIDAPRIYEGPSVLLASVNEAEPIAAGERDPSSHSSTAGGAQEETPGEYMRLIKYISKMQTDHDRRVQKLQATQDAALVKATKSAELEKQVESLQERIAQLEEQLAEKRDEVKQLTDSLLNANTVNTQLVQKNEQLIATNQRLLMTKSDFLDKDTVNNMIQQYYEQERAGNHRREDIIRILESMLGIEPPAATNQIPQVANARTLASQFIEFLDEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDH1</accession>
    <name>A0A061DDH1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769585.1">
        <property type="nucleotide sequence ID" value="XM_012914131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDH1"/>
    <dbReference type="GeneID" id="24565940"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313020"/>
    <dbReference type="OrthoDB" id="367238at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596051" evidence="2">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="27728" checksum="09FA0B80FCFC5ABD" modified="2014-09-03" version="1">MRRKLTLGLVWALFWLAAGPVSGDENDIAAPVPPEPAQPAQNNAPTLPAGHGEHRPLDSEGTPLSRIAHQLTHCAGTFTESLKDNVTKATPSERLDEMSKDVMKEMATNPYFKIPKYDRKIRELAVLHPTVMEKLGVYVIPIKPSSSKGDADTHSDGANPAEGQENKAEEATSSSNARMCYTHLTAFIATAAIKSNLAYILKQSEMIKAMTPEEKLQFIPRLKETIVYEIMSNMRTIENLSAQLGHESTFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDK9</accession>
    <name>A0A061DDK9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768526.1">
        <property type="nucleotide sequence ID" value="XM_012913072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDK9"/>
    <dbReference type="STRING" id="5866.A0A061DDK9"/>
    <dbReference type="GeneID" id="24564881"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302440"/>
    <dbReference type="OMA" id="TIWIYEK"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="441" mass="48968" checksum="A28CD58B85244BBE" modified="2014-09-03" version="1">MTFGFQACPSSVRIWHLKERADGVASKAHLCASYDAGCGMEYDIVLEAVIDNHFKKTVRSVRFSSDGRYLICASFDGTATVWGRENDDLGGLRKVEPETVHDSLASNDSSGLQTWSCLCVLEGHENEVKCAAFDCTSTYIATCGRDKTVWIHQRSYSSADNDAYDIARLPQGPSNGPLEFYCTAILTGHTQDVKCVCWSTNALLLASSSYDETVRLWGLIRQDWVCIQTLSMFTSTVWSVSFDVDGSRLAAGAADGTVFVFQIAIGKQPNIEDWLLSAILAVKSTQNSWTSRHIFLGTKARDYVEQLTELQRQVACTGAILKLGPIDATFSHVMARKMSKIRDHQLKHPLIADDWQPCHCIESHHSRPVYSVDLNTLLLTGGGDNMVKIMHPGNDGDGRRIEFVAHNSDVNGVSWKRHDSRLLFATVGDDEYIKVWKLVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDY9</accession>
    <name>A0A061DDY9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair protein (Mre11) family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0306140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768896.1">
        <property type="nucleotide sequence ID" value="XM_012913442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDY9"/>
    <dbReference type="STRING" id="5866.A0A061DDY9"/>
    <dbReference type="GeneID" id="24565251"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306140"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="3">
        <location>
            <begin position="578"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="815"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1266" mass="136655" checksum="6E5F865AC90FF975" modified="2014-09-03" version="1">MAPRFTSFKSVWNKVMQKNDIENAVSPEKPVAPKRTPLQLSTSNAALSSSSSSTIRSQSHRGGTRFQSTLSEEGEGSTPSLSAPNSYEEPAASDTSCRSAAYGGGAASAANNGPHGSKTPRATGSDPNHPIGNSTSLPNSRGTADSCGDRTPFDVSQPRNTGPSQLTPLGAHQAVSQGIKHGTNPIAPQGMQQNIPPDLLSAMDVDIHNSPLRQAPLDMRQGIQPQPFQHSDQLGITQTHLYQQSQVMQPAVQSQFQQAMTHVMQRELHDELAGFDDPLDAGMFRALIFTDSHLGHKESDSIRGNDAFNTFEEALFLAKHLCVDAIFHSGDLFDDSHPSRGVMYRAMELLRRYCRRGDGVGEGAASTLGIEIPKSCRPRNEDQRRAALKGMDMPISRERRIPFFVIHGNHDNPTAVNGLSPIDLLDVSGLVTFLGTANDMKKVELHPILISKENIKVALYGLGWVKDECLYEAFESGRVHFVPPDESQHHWYKILLFHQNRYARRGKGVKDYIPDSFLPGWLDLVIWGHEHECLKFPQRSESRDFQVLQLGSTVHTSMAQAEMAPKHCCLMELGPDDVKFYPITLESARQLHYSDINLSQLAIANGGEKEIWSRLSVMVEHVLRAMRNRPKTALRASEIANIVLPRNAKFKLEKAIQDAERLPLVRLRVEHTGFDSINPRSFGNDFANRVANPADMLRFWQKQNRQHRPDEGSEESSPKDSKVAGGSSVGADVRSHVFPVIENKLKLKVLLERDLNGAVERFAAGMEAQSIADYVRKTVEGMRKTLQKEMAAHIGEQLSDDVYGELVERAAVAHTESVRSSQGLNTSHTSTYVPLNRSLSNAQSDDPKTVTKVQQSDEVPPLNNSTGIGDTVMASNSDNGKSRDALKGSGVLNVSQSSNASLGLSRYAFKGAASKLGASAGVAMSRSLNEADLAKANASLSAKSAAIMHSPVRIHGTATTNPALGINSAPNSVPSADLNESVDLGSSMLGSGDVMLDFLAGASPSLNASRNLSHSDSAVLRTSGNSSVFSSLGHNQTTQTKILEHMARLKSRATLTHDATTVLRNPPSHNNKEYSTPLRNPTPAKVSGDPKRGRLNLSVSHDVLDIAAAAVSPSKRACLGDSGRFSTAGSSSDLPNPLQSMGCVVSSLSYGDVSPVSHDEHPLKLSDFDDLALPTGAGGLDRTCGNGVAAERSNITVTPSAAVTSATTPHKSASGKSPLGGDELSPDKSPKSAEPDAQDDANEASSQRSYSQGFRNTLISMFFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE50</accession>
    <name>A0A061DE50_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">-Tetratricopeptide repeat protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770170.1">
        <property type="nucleotide sequence ID" value="XM_012914716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE50"/>
    <dbReference type="GeneID" id="24566525"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404700"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="86" mass="9662" checksum="EC3FBE0548EAC272" modified="2014-09-03" version="1">MGMHQKALADLNKAVELDGTIEPQYRDKVCKLKVAAEKEFAKEKDEMMGKLKDLGNTLLGKIGLSLDNFKVNKDENTGSYNIQFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE56</accession>
    <name>A0A061DE56_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatidylinositol 3-and 4-kinase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0307440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769026.1">
        <property type="nucleotide sequence ID" value="XM_012913572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE56"/>
    <dbReference type="STRING" id="5866.A0A061DE56"/>
    <dbReference type="GeneID" id="24565381"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307440"/>
    <dbReference type="OMA" id="TMDCYIN"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044571">
        <property type="entry name" value="P4KG1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE-RELATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="141"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="625" mass="71023" checksum="775FD82C018B122A" modified="2014-09-03" version="1">MSSGGLRISQQNYFSTHNALRDVSPEDKGTRCVLHELHGDRHGAIRLYPFYDVQMVKRLLIKKLHLPSGTGVNDLRILYKGVELPNYRTMETYMGKGENDHRLFWSMRETNPSAGIRRAGIKTTSHMQSIINEIALSLKNNIKPKLTMDGTGGTYMMYNKQRVCCAVFKPIDEEAFAPCNPRGYEGKLNQQGFRSGVLSGEGASREVAAYLLDSAYGGACGVPDTTMVEASHPAFHNSCDAKFIKDVGSGLKWKTGSLQEFIDCKESSGNYNPSLFPVTDVHRIGILDLRVVNLDRNDGNILVMDLRQRSHDGQTLPPGVPRYKLIPIDHGLILPDVVDVADMDLVWFDWPQTEIPFGKNELKLIFAYDPDKDAERLRRRLLIRPECLRTMRVSVRLLQIGALMHLNLKQIARIVCRSDMDTPSDLETMIKKAVEQAYKATEATSVISTRRLGAAMDLFSHSVRFEACVEDNDTGVERAEESQFADDSTSSESSLSFSDESFATPQDELSSSSNPVHPATHELKYRDIVRTTYRRRRHVEEERSIWALEDAKGRPIHFDWDEQFDRTFYSLVVRMFTCYIQQHHPGWTSYPYNGDGDERFTWAARNNFTPPHADRWLQSSRPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE58</accession>
    <name>A0A061DE58_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="1">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769031.1">
        <property type="nucleotide sequence ID" value="XM_012913577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE58"/>
    <dbReference type="STRING" id="5866.A0A061DE58"/>
    <dbReference type="GeneID" id="24565386"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307490"/>
    <dbReference type="OMA" id="YPHMMFN"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="2">
        <location>
            <begin position="67"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="246" mass="27878" checksum="BCD59D87655C4E80" modified="2014-09-03" version="1">MDAHQPSQASANAEAVLKSPALRFNIAGLPALTAYLDEQMTDAALYSLENNVGILKIYTLYPHIADHIVIQKVLVQCLTRLPANDFDVCIAQVPIPTQEHPVIAEVISLHNMLQNCLFYKFWEAALKPMDDKVGLPFVDVPGLRDAVRRFILDVVPLLYMQMSVPELRSMLNYERNCEEFEQMLAACRWTLTSDYSRSNPDAGMCVPAARDDIAKSQRSHEVHTEVNKYFKVDSMRVYYSTMRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEE7</accession>
    <name>A0A061DEE7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769336.1">
        <property type="nucleotide sequence ID" value="XM_012913882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEE7"/>
    <dbReference type="GeneID" id="24565691"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310530"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7624" checksum="37C3AE02CF12AC3F" modified="2014-09-03" version="1">MAAPCSMRCCFSCASVKPDVGEHNEYRDKEVLLLCRGESLCSEVVELRALFAFDVAPTMEDQLDAEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEH2</accession>
    <name>A0A061DEH2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0311780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769461.1">
        <property type="nucleotide sequence ID" value="XM_012914007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEH2"/>
    <dbReference type="GeneID" id="24565816"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311780"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="105" mass="11529" checksum="4D9128FB7435ABDA" modified="2014-09-03" version="1">MAWWSATCICGTDCKTSDYSKSHARLRDVKTVTLALVHPHTSSGPHSAAVSTEPNSTDAESSTPSPHPYSAIAAVALIILVVCGMVYFRIRPFHRVRYLLRSRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEI3</accession>
    <name>A0A061DEI3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769516.1">
        <property type="nucleotide sequence ID" value="XM_012914062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEI3"/>
    <dbReference type="GeneID" id="24565871"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312330"/>
    <dbReference type="OMA" id="YTIMMES"/>
    <dbReference type="OrthoDB" id="367213at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="1">
        <location>
            <begin position="88"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="25186" checksum="AE25A7B483593285" modified="2014-09-03" version="1">MFIGVVRRSAACFARLPVERYLLPLPSRRDSVLSKLRFVPAGRRVFMDPVRKIHPFAVLALCRGDCPRHLRAFGFEPADQTAKLLLGIVHIWILHRRMHSAGLETEKMLLWDYLWSHMRTILCAQGIHELQFRANLEEMQHKTLGFCLALDESMDEIAQKGDDTTLRKMLIIYFYQRNSGMMQSQPLDLLTKYILALVDFVSEVPEEEFRYAAFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZA4</accession>
    <name>A0A061CZA4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0102800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766142.1">
        <property type="nucleotide sequence ID" value="XM_012910688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZA4"/>
    <dbReference type="STRING" id="5866.A0A061CZA4"/>
    <dbReference type="GeneID" id="24562497"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102800"/>
    <dbReference type="OMA" id="DNCMRFN"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45926">
        <property type="entry name" value="OSJNBA0053K19.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="725" mass="80923" checksum="6AA9606F89094499" modified="2014-09-03" version="1">MGNDNHHEARRRIYVLTTAEMCSFGGSDSAPRGAAFLGVFALSSARGHSPDPRGAGNLPQANFWKQWFHRMESGKIWRQFCAQKILKRMRADRFGTLFAHPVLEASDSVITPAVKEAYRAIIAKPMDYKTVKAKLDNGIYMTPDEFKDDMLLIYDNCMRFNPPVGVNKWIYDAAETNKAKFEKMWEASQDKVERLLAKANAQRQRGKHKAQYSASMNVDDDVSHKKAAATLNVSTLDTAVPATAPLRAVSDTAQTVTTVTDNTSEPASSVAAEPTAVATGGQAAATQSVEAGAPQQASFKFTFRVNLQAVQEYKQRLAAKARQAVPAEPLPEHLPQEAITIPDAPEPLPAAPELPPEAAATVVESAVPRDVTPNTFFYDETPHMPEVDMDETVAVSEVDLDKLPPIASRRENSILRVNWLSENECNQLFPHCSIIGLHERKKHYNVSDLALRCVYNELYMNESGKRTERTTRELIESTVKEDYTMKHHKLINFLLEKPAETPVPTPCTLHEFGEGDANSLTDVECYAPSPRDHDTFRDSTETLLSARSDDHDYDDRTPRAQTLRIELPTEATIGVGAAAERVLLKNGFRKVSIAKCTIKCADELSFTSDNSGYYKLDESEFMYHTAIMRHLRLFLVNCGTVYIDITRRTPPLAELILKHGMTSEVHDLYLESKCRVQKNLAFFQLPHAGCISYAANVDVLWRIQTVTSALPKPLIVLHLICRDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZQ9</accession>
    <name>A0A061CZQ9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0104150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766292.1">
        <property type="nucleotide sequence ID" value="XM_012910838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZQ9"/>
    <dbReference type="STRING" id="5866.A0A061CZQ9"/>
    <dbReference type="GeneID" id="24562647"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104150"/>
    <dbReference type="OMA" id="HAINCDE"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="5">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="203"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53749" checksum="E205507345922E77" modified="2014-09-03" version="1">MYTWAKALLAVICAVASALFSGLILGSMSLDILQLQLLTYVEPTTNQDRVNSKYARRLLPLRRDSNLLLSTLILSNSMVNALMVLLLGDMLDMTWGFIVSTLTTALLGEIAPQSIFMKYALRLCGIFAAPVRFLVWILYPFCKPLALLLDYLLGPSNQVIYTRQQLKALVDLQLEKGNVLTIEEAKMLKGCLEMSSVKAEDIMTPLQALVHIEENATVTKEVTQNIAKSGFSNIPVVTPEPDRRIVGFLVVKDLLMLDDSKSYRVNDLCATIGKPVYSVDSESTLNDILAFFKENSIHVVVVRKIVVNPATGGDPSYEHAGIITIDDVLQIMLQDYITDDAERELEGDQLVKKRNELQLEKFDRLNNVQTVHEFSLNSIRSVFPLRNPIPVLRALDMPENAHNINIISQKRVFLLKRNTLIPSGSIIVLLRGNVSYVDDENVMTLKLPHAINCDELEKTVVTRTECEVVEVELNENFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D016</accession>
    <name>A0A061D016_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavoprotein domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766199.1">
        <property type="nucleotide sequence ID" value="XM_012910745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D016"/>
    <dbReference type="STRING" id="5866.A0A061D016"/>
    <dbReference type="GeneID" id="24562554"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103315"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103315"/>
    <dbReference type="OMA" id="KGLACGD"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="161" mass="18156" checksum="D1CA177FD98A446E" modified="2014-09-03" version="1">MAEHRNLLIGVTGSVAAIKLSEIIDDIKQRAAQNAQRVEIRVVATQSAIKLFKQSIETSGCEILTDDDIESPYTRGDPILHIELRRWADLFVICPLDCNTLAKIANGLCDNLLTDVARCWDFRKPLWVYPCMNPLMYQHPVTAEQISKLQSFGVKVNFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D048</accession>
    <name>A0A061D048_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0105200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766397.1">
        <property type="nucleotide sequence ID" value="XM_012910943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D048"/>
    <dbReference type="STRING" id="5866.A0A061D048"/>
    <dbReference type="GeneID" id="24562752"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105200"/>
    <dbReference type="OMA" id="KTHCRDM"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="132" mass="15316" checksum="EE4676D8F93E1C5C" modified="2014-09-03" version="1">MTDQGAQVNRKRTFRTFKFRGYELEKLLEMPMENFISLLRSRQRRRFSRAKKDLAYGEKPEPVKTHLRDTIIVPEMIGSIVGVYNGKQYINVEIKPEMVGHYVGEFSITYKPVMHGKPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0H8</accession>
    <name>A0A061D0H8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766482.1">
        <property type="nucleotide sequence ID" value="XM_012911028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0H8"/>
    <dbReference type="GeneID" id="24562837"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106050"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="125" mass="14231" checksum="D10F010132E13938" modified="2014-09-03" version="1">MDTENLRTAFNNYANKATGQLESRMFVKLFKQAGLLNSKFTANDVDVIFVKHRTKIPTQRFWWRKRVLPYTRGQKPFPCVCTTIKAATPAFTPTEDHRSSDQTTPSSCGQCGCVLICYTHALKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0N1</accession>
    <name>A0A061D0N1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765888.1">
        <property type="nucleotide sequence ID" value="XM_012910434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0N1"/>
    <dbReference type="GeneID" id="24562243"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100310"/>
    <dbReference type="OrthoDB" id="366468at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="813" mass="89087" checksum="55837636181768E6" modified="2014-09-03" version="1">MADTQETEMSEPAATLTQRAAAADAETDLSDAFSDAVPKPEPAAESQTYVRRTRWSSAIMDGVDPKMRYANKRFSDIYEQPDDAELKKARRTKPSPRETTEAPIFVQQDPTCSEDDSESSPSIDIRTIRNILNAIRDVVTALIPKPVLITDLSKDQSKEQKHESVYGTRSASARSQESINADASATAPGGKASETEHIGMCDDLKTVQKDVGDLLNRGMYSRNEKIKFVVYSILELVALRADHYYRMIQNMERLARYAHRTESIPTDFVTTLIDMYGAAALQHLEHIRRRMPIKVRHTGVLNFKPWRAVFGGTTLSMENVNDLLKKYEFKKLKDMAQTRTKNVRALMQEQQSAMLKAIEARNRESMLSASYAKLRQTDAQKKGGITSLVSTAANTQESIGDALMGGESLKAKTEGRAAQKGKSETGRARAKAGAAQRKDSVSDAQDAGQPKTASSKRAGGRKAATTRGGSNAARPGKSKSLELERTKADDSDGPIMRRKHGSLELAGTGLFTDDDEAAFSEYSDEESKRNDSTKSKGRSRAASFRGKNKSPDTTSTSPTQIGARGAPNRIALARRMALNRSGKSVESWRNLKMTSGFEPVKLDGDDTLKIPKVKRDPTPKAAPPTEEAASPAETPKAADSAPTTTVGTPERAKQRVVYETNRLKEGPGSASFSPPPNPYRKHVPPNPRRGGPNITGGSPPGRMYPMYMIPPPPPHPNMLMFHNAMYNAMPPHPKAPWAIPPVAAPAPHIMSPKHCHPISPTWRNQGPPPEGLDSPNRGRGFPKRHHQIPRNPNRRPPRGPNSNPASPKSNRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Y3</accession>
    <name>A0A061D0Y3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0107690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766657.1">
        <property type="nucleotide sequence ID" value="XM_012911203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Y3"/>
    <dbReference type="STRING" id="5866.A0A061D0Y3"/>
    <dbReference type="GeneID" id="24563012"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107690"/>
    <dbReference type="OMA" id="RYTNYIE"/>
    <dbReference type="OrthoDB" id="365144at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1212"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1235" mass="137056" checksum="A9A9AD47E8145FFB" modified="2014-09-03" version="1">MRLSASGSGDFAFLASAYSDKSSSSKVVASRLRSVLTPCKDATALEGLLDYFGPYVIDNTLRGLLSRINNSQKSHRDSILNVTWLADSGVAPEHASQGSLTSVDDLGISDASPPGEDETFASQSVLSDDSDEPIVPALDRSVDRVVLVEPGVVPRRALSRFQSEFLLEQLNPVLLRSYRGANRVARGNDSRGDYTTNFFSKYGSFEGAVVVHSSTRDSRSSNSLGSARSVASGIEFLGQLCTPELFSQVCSVKEGGALVGRCEEDTFSNDSIIAMASLNDDLSDEDRALFAPLCRMIRYMLFFVVDSANHELQWLRSFDAVVTDVVTALDRVVSDSAGMSKTIKNKLREYNAEYTSTVAAYDKALAKFQKLEKALESSCVSRSFTGVPDPASSFYCTFEACHSHEPTFLETRKAHWGTVRDLLSSRKDFVRYTNYIEQMCLTHSLRDNLINGRETYMHGLTSVLSMFANHYPWDVFAVEALCAEKITGVSSRLLAGAFTKSRSLGLCEDTLIKVPCDGTVELRFSLNVESASMKDTLHSVVVDSFDSMRTLSKKLSQLHRSQMERFSRFTSRYPLKLCGTDLVAMFKSYNKYHKHLSTQWLSFSSTVGAVFPKHVSNLRRAKEHSQPVLGEFLELKMPLRLFGAILHHFRLICDTAIAHSLKVCSEAMVVCGSSLEWPSVVTALAASGNMDAQQLQEAIEELQSDDCCTTDDLDQTTCGAEDAKTAVNPPISGKERDEPVVELQGEIAPCESSIAASKLLSVNEMLAEALVDYEEPNYDFRFKCGDAIHVLIAGNTPLWFGHASAGVNRWFPAKFVQVLWERDVPLFRRADLECETHLDVYRVYKGEDNQAVRRQDTGITLTSKSTLKQAMLLSKLGLDGKVLHEFKCALCRKIVLSGTLYLTKTHLGFVSNFNDATLFGMQTTLTVPLCEILECDLNSPRSISFYVRILLRNGDSHMFHSVINARRIRDVILETIQEKDVDEPTAQFAEDAECYSESLKSMFGGLAPLSKSAPSTQLEMSLQDFFVKTMRDNVTPGSIIADTRLSHNAFDFSGTLEPVDFDWHAGGVQFRERRVCYSFRLKETKYTALLVRNSCGKAREELKYALVNKTKLLYESATYTSDIPYSKYFYTLLRITATAVSPTSIIVKAEYDVKFVKSTMFSSVISAEAYDRLANSAKLVLTAGDQSPVKLVSACDEETAVSPRKSEFINNGIRSLMCICVLFLGIYTSLLSGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D105</accession>
    <name>A0A061D105_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0106020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766479.1">
        <property type="nucleotide sequence ID" value="XM_012911025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D105"/>
    <dbReference type="STRING" id="5866.A0A061D105"/>
    <dbReference type="GeneID" id="24562834"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106020"/>
    <dbReference type="OMA" id="WIIFVIE"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="120" mass="13235" checksum="4DE68B9C10EE10D0" modified="2014-09-03" version="1">MESGIKVPQETIQAFNQMKLKKACKYMILAIKGDVVTVAGQGSGDVEELYSSLPADDCAFVLYDTGRYVVLFMYAAPNAPTNSRTIYSTTKQTVEKALEGSKVYKHLVEEKDEIAEALKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1P6</accession>
    <name>A0A061D1P6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical multi-pas transmembrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766759.1">
        <property type="nucleotide sequence ID" value="XM_012911305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1P6"/>
    <dbReference type="GeneID" id="24563114"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108710"/>
    <dbReference type="OMA" id="MFIFYWA"/>
    <dbReference type="OrthoDB" id="359547at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021691">
        <property type="entry name" value="DUF3273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11677">
        <property type="entry name" value="DUF3273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="332" mass="37895" checksum="FB95B2B860024F31" modified="2014-09-03" version="1">MTELPMQEMSHMAAYEQYPYEGQPQDQYGMQYSHTGQMEADYVMENEIVSPRGEQHTPMVGFFSSKLLRTGITFQCTALTLMFIFYWAFGGNGIFVFDLYAAPESVKISRPFHLTVSSLMALYLLGTFYVAMFQVFVSDNSKAVRGFRAGSKILSAAVTLDLISSMLRLVQYIYAYFYMSMKWWTRYQQTKADWIFFQFGSFTNSFALVMYGAAFFYLEAYHDEGTSEEIAWTNLVLFCLAGLTELLMVFTGYGALFSLFLLAAIMSATVWSFSFEPLLEKWAPSLHSRDVNADFADDAYEHGYETASYVHEQPAYSQVPSQMDGGAYYQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1W5</accession>
    <name>A0A061D1W5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766814.1">
        <property type="nucleotide sequence ID" value="XM_012911360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1W5"/>
    <dbReference type="STRING" id="5866.A0A061D1W5"/>
    <dbReference type="GeneID" id="24563169"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109260"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="295" mass="32614" checksum="5B6F6B34FEFD5A20" modified="2014-09-03" version="1">MVEMKLERKKCKCVVFSCKGGKELCTDSKCETCMACCHPDCKGCEKKCKDGEKCKCLNLCCGCKENCYGESKDGTCKGKGSTDCQRCREKCKDSQKCICYQCNCGTQCNGFLCACCYFCNPGKCKREGTCDGYVIGKCTAEKGCQGHGTYDDEGRPVFGKKCECGPKGSGKDCTCYTSKRNPNDKKCRCIFGDFQKDGNCLIKCDLCGKLCSQDSYIHRGTLVVVPLAIAMVLIIVWVKYRDIIRKVFYELRGSSSRAPKHSSAYTKNLIGDRIPEESNIDRYSAIRPGTYGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1Y3</accession>
    <name>A0A061D1Y3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0109410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766829.1">
        <property type="nucleotide sequence ID" value="XM_012911375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1Y3"/>
    <dbReference type="STRING" id="5866.A0A061D1Y3"/>
    <dbReference type="GeneID" id="24563184"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109410"/>
    <dbReference type="OMA" id="NCTSYVG"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="223" mass="24425" checksum="4BD3AAC8BFD2FFF3" modified="2014-09-03" version="1">MGKKSGKHKANTGNDLQLPRPAEQVRFLYQPALPGGDEASTLNKLAERAGESTASWKAKIESRVLQLNAAVHEEAAALVGRQPEPYTVRHSFTKFSGLSNRAAKRAGLLSVGPEVDFEHAQVLRTLWQEYIADVLGKHSAPAHVARNLALCDLHGAYVEVVGSACAAYAFYIVRSDSRVALVLKEGTVFALEWDRWKFHIHGAHLAATPAQRSKRKLKAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D228</accession>
    <name>A0A061D228_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766982.1">
        <property type="nucleotide sequence ID" value="XM_012911528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D228"/>
    <dbReference type="GeneID" id="24563337"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110940"/>
    <dbReference type="OrthoDB" id="10363901at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="225" mass="25623" checksum="2414D220EFBBB852" modified="2014-09-03" version="1">MVYNSLTEAPHTFREGIDWLIALKGNDAEKNLAAMGAALHKFLADKPVGKMELPALEEVKRISKQFVAQPELKYMWPADDVLRRFNERIIKSHRQLRKIVCTIYDSDYLNVIKSKRLTAQKITEQLSKAVDGCEKFLDKIKIPDEYKSAYSSEATWETSCSENPEACAVVLVGIAPMLYTGLRFLQCGPEFRTKMTTSEVIKASKSISYQMLVTLYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2A3</accession>
    <name>A0A061D2A3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766924.1">
        <property type="nucleotide sequence ID" value="XM_012911470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2A3"/>
    <dbReference type="GeneID" id="24563279"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110360"/>
    <dbReference type="OMA" id="WIIMAMA"/>
    <dbReference type="OrthoDB" id="366465at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599958" evidence="2">
        <location>
            <begin position="26"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="470" mass="52864" checksum="4C42F6724DCCCA07" modified="2014-09-03" version="1">MVGGAAIKLVTALLMHLVAVPLAAAGIWDIAEMQHAHFLLNSPHPTLYTSLCDPEQSLLRRKFQIACFVSNNTPFNMWDNSPQNATSIIVMPELSFEQTYIMDITVRHAVRKASASVWLYRELTLQVAHIILESTKTQDGDENGGKDGLTDPASGEAHGTEDATGGVTPARGSAEYVSQMLVQRMKENVEKMMGDKSRLLKECVIAPKEMCRGHRNHITYLRDLFPNFLNASSRAASNFNAADGKTFPPRGDEELGAFGAANDDILIQYAKRFLVTQITMYTQDAKKTMEEALWLRECLLINEVNTLVYDMTEYSGELHRLIQELVVKIMNGYYHLVTIAIKMLDANLKAIRKLEPDEIWAQYAHSVSISQKFARDIKATLVEIMSAQHYKGLKDVFNRYALMTGRKRLITQPRRNSTTLLVLKTAAIRALKEEITVETAQRVFGIIGTREWFARLATEYRSVSAMISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2F2</accession>
    <name>A0A061D2F2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767132.1">
        <property type="nucleotide sequence ID" value="XM_012911678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2F2"/>
    <dbReference type="GeneID" id="24563487"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201030"/>
    <dbReference type="OMA" id="HLFEDSW"/>
    <dbReference type="OrthoDB" id="364215at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600538" evidence="2">
        <location>
            <begin position="28"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="311" mass="35931" checksum="A927C265B9CFB193" modified="2014-09-03" version="1">MVRRCPWILQFVCALVLLTNECAHVFAEDDSSSGSDTCPANRDIFTRTTFIKRVMGYASDSYLTSPIRRPGDQNDEPAEDDGTTSDAGEHSVDSDDEHDHLDIDSPDEDDAMTRLKNVFSKHRQKPYTREEFTEKLREILITPDPLYGTEYNKDWGRACMTTDYEIPNTEDLIHFNVFDPFMPPGLLFEDLRCLHLYNVQPEYHLYKVRMGDMVLTLRPDLEDASLHLFEDSWGLMVVRVLFTVDGVLHRYEYTENSRGSRVFHKTMGPAMHYAAPNTDTTDLNKWLDEKYYALSRRRPPIIEEVLTAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2L6</accession>
    <name>A0A061D2L6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0111360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767024.1">
        <property type="nucleotide sequence ID" value="XM_012911570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2L6"/>
    <dbReference type="GeneID" id="24563379"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111360"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600543" evidence="2">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="121" mass="10835" checksum="DACFE284A1DBF51F" modified="2014-09-03" version="1">MRGLGVAVVVLQLVEGSGSGSGTCCSWLRGVGAAVVEGTGSGSGSVAVEGTGSGSGSVAAEGTGSGSGSVAAEGTGSGSGSVAAEGTGSGSGTCCSWLRGVGGTVVKGTGSGRGEDVGGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2N2</accession>
    <name>A0A061D2N2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0200150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767044.1">
        <property type="nucleotide sequence ID" value="XM_012911590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2N2"/>
    <dbReference type="GeneID" id="24563399"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200150"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="463" mass="51562" checksum="8EB97D9F9E0504CE" modified="2014-09-03" version="1">MATGCILQVRHCAKTSTLSDDLCKPFYNVVHNTEGCLSSRTASEEPYLCDVISRLSTLQGSAPKDSENPHKNIIHNLCASAGSLLGDQFPGTYDGSGIVYGNASRLCDAILAFLYAVFSDVHGNQPYVAGRDVLHDVIVELKSQLWRGHKGFRQAIPKVVTGLQRYNAAVEASNEKVKEPIETVLDYVAPDGQLRKGIQALQITETSTSTQDERTVESAASLVEDCKEVARVFSKSLTAATNAINDLNPKLKRKLEDARRSFFNHVDWLSRWSKKGQKKRLDKMVQKIKTRLKKLAKAVRYRIRQEVHAVVVLSKDRASEIKMKLEGVTASLEEYVKELGQWMGKAKKYIQDVKKYVGNIMEQLDGEHRKAIDQAAADIDSELGKKVEELNKWITEAETAVSVVKEKAENVYGRLDRDNSTTIGGGLKKIEAARSKVESVMIWKIGKMPRTVCSPALLGRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D379</accession>
    <name>A0A061D379_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766733.1">
        <property type="nucleotide sequence ID" value="XM_012911279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D379"/>
    <dbReference type="STRING" id="5866.A0A061D379"/>
    <dbReference type="GeneID" id="24563088"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108450"/>
    <dbReference type="OMA" id="CEEQHIT"/>
    <dbReference type="OrthoDB" id="366479at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599995" evidence="2">
        <location>
            <begin position="25"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="849" mass="91706" checksum="F0199EB820D5B12F" modified="2014-09-03" version="1">MGVRLSLLHLWCLISVHQIYRVDGYGSGTLSLLGGEINPTYDFFGELAANNSHKKHNHIAERGNGHHHGPHHGSEGHGHEHHHEREGHEHGTHHKMIHEHGKDGHNAHNQAHSKHHHNHAGGADEHSGHHEAGHHGHSKHHASFCETHNCPGGRKGVRLDETGGLPLFPSFLASDIPGFLESRNFLYEPSHAAIATIPVHPHQFLERESEAHDVAKHESAKDGSGHHGSAKHENVEHGGDPQHKSKSEEAGNGHNKSHSSSKDEDEEFEDEGDDEYLKDDYDDEDDEGEEEGYDDEYMEDDLNEDKESGHDNVPVCKLAPVGNHPKDGNVVQGAEGQQSGTQGATDAQQSINATHTEHADAATAGEHIAGGNIRVDKHTGLACRIRPEGHSDGAEQHTETAPLNSHHEDMDIRSHNSENASAATELNAPKAAGDTADDAHHQEGSAVNTNESSEHTEKSENTGSEHSADQSTAASVNDSSADTSHEKESGAADEVDAEDSKGDHNTVDEEHHEDAESTDSDHKTASEENDKQEEHDDEEANHDGKVNDEAQEHDGKHASEEDDEEFDDEDDVKNASAKEEDANASKEENKSHPEGTSASAEHANSDSSKSKMDADEESADAKSEDDDKEEAEDADDEEDEKHNEKEEKHESESHEAEEKSDGAEHHESGKDSANEADAAKTDSKPAEKEAKADNPTINADTANAGANKPEANKATAQPESTVIQSAASAIPQDVVNKVEPIASPTVDGKAVAVATAKPLVDESAIPYCSGIDSDEGAASAYSEEGDVQSSKPGSTKEDGEDDNEERDEEEHEASEHQEEAEEGENGNQSKNDEEEADEKEEEGEEVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3M9</accession>
    <name>A0A061D3M9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0204540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767482.1">
        <property type="nucleotide sequence ID" value="XM_012912028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3M9"/>
    <dbReference type="GeneID" id="24563837"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204540"/>
    <dbReference type="OrthoDB" id="2191799at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="139" mass="16229" checksum="1B89D8D7738BBBB6" modified="2014-09-03" version="1">MLSKLTWLLSSADARFVDFLLTINAVTKEVADRIHAVLGRQIGLSKETIDAHKIESEVHGKYRWIAYDKTVKFQKTKEYNRPDIILADRRRNTITIVEIGISNQYNLVDTEFKKHKCEDIIEDLEARQFNQQTKIRVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3U7</accession>
    <name>A0A061D3U7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0205440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767572.1">
        <property type="nucleotide sequence ID" value="XM_012912118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3U7"/>
    <dbReference type="STRING" id="5866.A0A061D3U7"/>
    <dbReference type="GeneID" id="24563927"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205440"/>
    <dbReference type="OMA" id="YIATFEH"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060169">
        <property type="term" value="P:negative regulation of adenosine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF43">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="354" mass="40327" checksum="71B2D0946E652D58" modified="2014-09-03" version="1">MMMATYPTNAELQKMGEWERKAIWRKMPKMELHLHGDIACPIYSDYASGDTAFTEQDILQNIVCNYKIKDLVEFIDKTRMICKIFSNNQKILERCTTEAILAKHREGVVGLEFRFSPAYLAEGCGYSFDEVLDSVFDGIEQAKQQITTPFEVGAIYIGEVGIDDKFSFEDSVDYFLKNREKFIGFDNAGYPAPFSPHAAQFKRLVDAGVNLTLHAGETPPDCNDRLATALDLGAQRIGHGIECVKSPEMMKRLIDQDVILEVCPKSNWITNPAINMNDHPIRRIYDAGVKICINTDDPMMMTNSLHEEYDMLFTHLGFGYEDFVKMNTWALEKSFLSREAKIKLKETYFPGAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D425</accession>
    <name>A0A061D425_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmodium falciparum CPW-WPC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0204610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767489.1">
        <property type="nucleotide sequence ID" value="XM_012912035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D425"/>
    <dbReference type="GeneID" id="24563844"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204610"/>
    <dbReference type="OMA" id="ENICIAP"/>
    <dbReference type="OrthoDB" id="359569at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006387">
        <property type="entry name" value="CPW_WPC_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01492">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09717">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01099">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600586" evidence="1">
        <location>
            <begin position="21"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="152"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="210"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="495"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="CPW-WPC" evidence="2">
        <location>
            <begin position="556"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="619" mass="68426" checksum="34763C026F1F0D10" modified="2014-09-03" version="1">MRSCVKLGAAWLLCIHIAAAASSSAAGSVLFDSVLREARARYTDAGTRLTQEELANTVTESLKKASQLLGLNLPVVRGDCEFDFSAFCPEGWVSSGDGVHCEVAHADSADAGCCGSQLDMRDKSPLDKLSLSNMCNLKWPCRTSSAYVSLDEGICPRFWHREGEECVADHTYMGPCDTRLNLAGKSLQEREDIARKCGLAYSRATGLLDESSDWSADCPLGWSLHEDGTCVKNADQTAGMCGGVLKFVDIRDKRDKSRRCGLVPIKGAKVESHCPLGWRYDADNELCLAPPSYTGPCQLRMDFRNYTTEEKALWAHVCGGSFLDGGVTKEEPTKSTSNVSYRSGALDHDLSVVRFSKPAKDVRVIEKQLDDGWRQFDGVCVAGETYSRIMPGCRTIHHLSDEYEERCRVSHRTDDVLEDFVRAYCPLGWRIRRVYYGDLVRHICVAPSAWSEPQKVECGGTTVDFSTRSPGFKRRWAFACGQRFPKFTDTNAARCAENFYWRCPAEWTHDGEDCVAPKHYGGPCPPKVPVSQLASPSMKAAFSQRCHAAWPCIGYCEKDYSADCPDGWTRTEEGCKLSSDSGGGSCGNHIVVPKSVRWGPGPKEELEYACDVHWTCKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4F2</accession>
    <name>A0A061D4F2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767644.1">
        <property type="nucleotide sequence ID" value="XM_012912190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4F2"/>
    <dbReference type="GeneID" id="24563999"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206160"/>
    <dbReference type="OMA" id="MNVESHI"/>
    <dbReference type="OrthoDB" id="366324at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="350" mass="38791" checksum="78A043E55926C4AF" modified="2014-09-03" version="1">MINMNSENDECLHLRDYTTHDSNLIPVLPEEIEFRRVDNFHCRNLTIVEHSPIAVRKFQELTKELGTVKEPISIVLPPKLPFDLGNYHPCLDSQAPTISDDEDATNESVSSNDVFAASYTTLNEPCYRLAERIYHLEKLKMEQRSIRSSITIADTLDGEQPFHDESDDNKSTCSLRSASPAAGGTGFSTAREQECNPPGSEQGSTQSESPTSTGSYNDRDAVLSESPSSDIDEQPQAGGDINVEDEHHGTPNATGTESTGQGERKLHHVSTYNVQPPMVYYDPFDEPEDDHFWPFSLGTSVWNFMVGSSRSLAPQNSAVMNVESHISSFYSKEGEFCVAAHVTCLQSFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4G1</accession>
    <name>A0A061D4G1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767654.1">
        <property type="nucleotide sequence ID" value="XM_012912200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4G1"/>
    <dbReference type="GeneID" id="24564009"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206260"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600031" evidence="2">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="394" mass="43634" checksum="E6C3C4BD0CEFA34B" modified="2014-09-03" version="1">MKVCVSLFLLFFSAINASAQTSSLPTSPLSNEEVGIHRFGSLDDVEYTPSVEKHCTSNDDEDSRVDITGSPIEEVEEVVPEIIEETPAAEEEVEIEEQVPEVEEVIPEIIEETPAAEEEVEIEEQVPEVEEVIPEIIEETPAAEEEVEIEEQVPEVEEVIPEIIEETPAAEEEVEIEEQVPEVEEVVPEIIEETPAAEEEVEIEEQVPEVEEAEETVEEEVPEIEETEEVAEGDESIDDSMPPIFNYQFTPIVKFGDEQNSYGLRDRVRIRVHIPPRGGRRSLRGKSTPNGDVLLYAPYGTPSSFEEMEGGFGCSFQGDMVDTEVGDAEVVEVFNAQQVSNVFGASPSVEGRSTMNACDKKPVGGARRFFGNLFFYGPGNDAYTEGRPVAFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4M5</accession>
    <name>A0A061D4M5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101450</name>
        <name evidence="3" type="ORF">BBBOND_0102230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766002.1">
        <property type="nucleotide sequence ID" value="XM_012910548.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766080.1">
        <property type="nucleotide sequence ID" value="XM_012910626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4M5"/>
    <dbReference type="GeneID" id="24562357"/>
    <dbReference type="GeneID" id="24562435"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101450"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102230"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="85" mass="9490" checksum="250326EB115FA8C1" modified="2014-09-03" version="1">MEQVIIDTAKYAEDISTFVKHIAENLDRLIHFGPPPQKHHSERDKNDNAREDVEQSSNDTFSAGSEDGTEDLPPEDHNSESEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4R6</accession>
    <name>A0A061D4R6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207210</name>
        <name evidence="3" type="ORF">BBBOND_0207260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767749.1">
        <property type="nucleotide sequence ID" value="XM_012912295.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767755.1">
        <property type="nucleotide sequence ID" value="XM_012912301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4R6"/>
    <dbReference type="GeneID" id="24564104"/>
    <dbReference type="GeneID" id="24564110"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207210"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207260"/>
    <dbReference type="OMA" id="WCIATLL"/>
    <dbReference type="OrthoDB" id="361585at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="26458" checksum="334D583CEFB98B0A" modified="2014-09-03" version="1">MSALLRELCPVNVLRPTFPSSVTSSSVSALVAVYNDAVSRESGALERALREVYSLDSVSLPSVIDFEGMSSYHSSVLRGRRLSVLSWIALNWKGCVLRTDVGLYGALQKSLHGVDGDALSTLTAAMFFVLLSLSGIISGFRLFGNSLVQWLWCIATLLLYNTSFVFSHSGIVVLWTAVFHLVGLLVLHGAVRPKSESRGGAVDGSASYLRAHVCVRGLFMVATIIGTVATLPSLTPLSNTGIRQPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Z3</accession>
    <name>A0A061D4Z3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thrombospondin-related anonymous protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0202740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767303.1">
        <property type="nucleotide sequence ID" value="XM_012911849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Z3"/>
    <dbReference type="SMR" id="A0A061D4Z3"/>
    <dbReference type="STRING" id="5866.A0A061D4Z3"/>
    <dbReference type="GeneID" id="24563658"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202740"/>
    <dbReference type="OMA" id="GSHKFKT"/>
    <dbReference type="OrthoDB" id="372508at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600056" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="45"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1061" mass="112210" checksum="30829B73186ABF89" modified="2014-09-03" version="1">MRGCFALLFLAPLAQFVLYCAAGAPIAAPRMHGDKLPRTCKRQMDFSIVVDESASISKEDWNGRMIPFLENLITTIDLDNSDIRISLTTYSTPTRSIFTFLDKEASNTQLAIKRLHEMRDSKPAFGMTYTGNALSFVRKAVLPYGRKNVPKALLLVTDGLSSDSDLTAQEAAMIRDEGVNVMVVGVGDARIEECRGIVGCDGVMDCPMFKHTNWKEMINIFHGLMKEVCDTLPQDATCRPVWSDWSECNAPCNATGTRTRTLRTLETITKPIMGTNGQLGRTCKDQEMLTPPQSESCVGKCANVSAPGHDMPAPMLTGRLADGSYDESYGTFASCTKHKSGDVPADKDIKCDRRKQNNGNSSGAGASQTPQHKVDSAKSDRQIRPQQPSAPIKPLPRKPTPGKVTHVKDDSSSQVRLRGDMDPTAGEKDNARLAKSPPTTKKPVVVTDSSQKVRRTAVDPNSSPEGGRKTPQSPSKPKVNSGSVNVPAKPGKASKDSVTVPGGSTLDPDYGSHKFKTETKMDPLSVNDINGSSTTSGGKSSDSKPVPMSSGGKKTPQSPSVPKVNSGSVSVPAKPGKASKDSVTVPGGSTLDPDYGSHKFKTETKMDPLSVNDINGSSTTPGGKSSDSKPVPMSSGATRGDMTDSELDSGSVSVPAKPGKASKDSVTVPGGSTLDPDYGSHKFKTETKMDPLSVNDINGSSTTSRVASSDSTPEPMSSGATRGDMTDSELDSRSGMMSTEPASPSEDSVDVTGGSTLDPDYGSHKFKTDTKMDPMSDGSSFPTSDLGREDESDMGEMTGSGTSLEHNTSTGSTPQHPSGYEGLNDADMSDMTPEETDLAAQEEMRRELEEEREEDLRRELEEQHKKEREAEERLKQELSANSNPGSGEPTPTSGSDITSDEEGATTGDVDTSGDEGATTGDVDTSGDEGTTSGGENATTGENSSSDDGDNSLHGFHVLSDSAATEYVPPVKAADNESDEESTEGGSSRSSSNTTKIAGGALLGLLLLGAGGGYAMYKKNKGPGFEADPGDYAGGDESSQPIRDAETYTVTEFDNNIWGEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5D6</accession>
    <name>A0A061D5D6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0209210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767954.1">
        <property type="nucleotide sequence ID" value="XM_012912500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5D6"/>
    <dbReference type="STRING" id="5866.A0A061D5D6"/>
    <dbReference type="GeneID" id="24564309"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209210"/>
    <dbReference type="OMA" id="KHTHISE"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="430"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1136" mass="122346" checksum="1F2EE53D8C9BC2B6" modified="2014-09-03" version="1">MEDSPNRRSPGAHNAEAQTPGAQSVDRGSDGAAVGANTPVVAGGYIVGERPALVNGGRSLAVVNNQKSTIYECKRGQKVADCTLHDDMIVSCDTFAYADDIDLVFTASNDGILKILAVAQQDGGTEERALLATFRISNGGLLSVRPAKSSGQLVGVYASGEGTEETTVVLIELDYAALLDPDIQFPLDQPIPIYGGGVGGDNGHHGGFANTVDSMDVDVANKNVAVKGAGDAVVDKCSFGGSDALSDATGGGATVNMGDGQHGGTPRSADSVRNSADLCRTLHKKFVKSRRTLCVLPSRVDVFATDAEVDAIAFAVGKTAMILNMAARKIVFFECFASISCIAFSDSNTFAVGDSRGRIAVYCIDTTKEAPATDNLVMTCNLPNDTFELNATQFRKVLLAFHSSYAVIRDGSDMGAFENFKKVTASVNTLIWHAHGVNCLAFNSNSTMLLSGGEEGVLVVWHLSSGAKKFVTRLGSAIFHILCQPDHGWYILCCEANEILFIDPFALCIRGRIASVAVPVYVGMKVNKDVSLTAMPHGPSSASLAGGVHVDINRANVSLTIGDCPTTPLIEHWPMTVADWVSPAGDCPPEVVGGNVAVYSRSNKLQIYNYVHDREVGSLTLKNVNILSRQDDEFGQDWELEGLAISTDGRVVVTVQSRSVMNSPSTADAEGNLGMLPAFEHELLRNNKKGLLKFWVRQAADAGNGHDTGHYEENTKISNPHGHRTTSIRQLNSDYAFLTTSLDSEFKLWHLIRKRVLQSDDVFATYKTLQIGESDRNVNLDEPGSCMWLCVAVGSYKNLPCFSSSLAMSGGLIAVSHDVVVTFWRTDAQCSSIKLLGAVPLVDDSEPTLDEEDMQGLGGHHMLAFIHPDQPRLILHSKRSRLVVVDVASGVIVWSYPLAEGQVVDQVIYSPQLPNLLVVATSTIDITSNECSGALEMFWLNQTEGNGFEIERFYVDQREISKIVLNMCLTPSPHVRGSAGRKSQKGETAAPAFDRNAHASALVLLTSNFNLETVSIVSDPFSHQTPRVQGVKRAQTTLPSLRKVPSMQRTPHFDVVSSILAALRSDAAGQKKRAKHNLAEQLCKSTEWQHRVRHPMPKSVLGAMVDAGCPTCALPPPNIVLNRLLHVATVRHLRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5M3</accession>
    <name>A0A061D5M3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768212.1">
        <property type="nucleotide sequence ID" value="XM_012912758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5M3"/>
    <dbReference type="GeneID" id="24564567"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211680"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="97" mass="11128" checksum="16D55874B0B89E09" modified="2014-09-03" version="1">MDDVHARLSEDSVLKISAQNILDSVEDALRIPEHAVNGVQRFQELTLQLYLRADLAPAWTDLQKKANLLKQPLIESFRDTCVLLLNRYPEAHCFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5T9</accession>
    <name>A0A061D5T9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0210730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768109.1">
        <property type="nucleotide sequence ID" value="XM_012912655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5T9"/>
    <dbReference type="STRING" id="5866.A0A061D5T9"/>
    <dbReference type="GeneID" id="24564464"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210730"/>
    <dbReference type="OMA" id="PLCHQRI"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600077" evidence="5">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="273" mass="30142" checksum="B369D6BF65A5D86F" modified="2014-09-03" version="1">MYNHRITLILFGVFIALALAAKDADGFALHQPPPRRFALYSKWLMEPKFPKTTKRYITTRAGKTEVIGQLKELLSRSSVLLRFTYKRFTPKERVVLNRKLRSFIYTGKDGSEPCAKLRMVKNTLIEKAMLGTQWEVFAPRMHGPSMCCFVFDDGRLPQILTAIERLRMADKKIRRHVTLDSASFAGKVVEPLELFRIADYASREDVIARLMCTLNGGSAGVARGLKSVAAKLAIALNETTKKGDASDAASSAPTSSTDNVATPEATAVAAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D682</accession>
    <name>A0A061D682_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0107358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766620.1">
        <property type="nucleotide sequence ID" value="XM_012911166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D682"/>
    <dbReference type="STRING" id="5866.A0A061D682"/>
    <dbReference type="GeneID" id="24562975"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107358"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107358"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000006">
        <property type="entry name" value="50S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="178" mass="20257" checksum="36A07E81135CCBC3" modified="2014-09-03" version="1">MRYLGRYRLIVPAAVAKPSPSIGQALGPLGINMTDFCKKFNERTQAIRSNVPIQVLIYTISNSTYKFSLRTPGSQWFLRRIARVPMGSPKPKHEIVGNVTLKEVYHIAKCKSMDPPLIGVPLYVICKRIIGTANAMGIAVTRELLPEFRKRDYTKVSQLDQMRKDIRAQKRSQKRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6F4</accession>
    <name>A0A061D6F4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0207520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767783.1">
        <property type="nucleotide sequence ID" value="XM_012912329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6F4"/>
    <dbReference type="STRING" id="5866.A0A061D6F4"/>
    <dbReference type="GeneID" id="24564138"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207520"/>
    <dbReference type="OMA" id="TFANSDH"/>
    <dbReference type="OrthoDB" id="10266805at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600645" evidence="2">
        <location>
            <begin position="18"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="3">
        <location>
            <begin position="184"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="458" mass="52951" checksum="807F6EA70CD77AB1" modified="2014-09-03" version="1">MLLPLLALLFNCAVVRCRCDAELDSAARYEARYGTQLAPSPPDEEYAEPLGRLAFGSCQQFDLGDNRIFPAISRARPDLFLYTGDIVYPDNHCGTPECLRGYYTAARNHPVYSEFRRQLRRIDGIYDDHDFGMNDGHDSFQHREASQQILLDFLEKPAGHYRRRRAGAYFSAEYRNPHCPVHRVKVIVLDMRYHRNSFYYCACHNCHWYKPCMHHYIVRRLWNYLSGFGCNHGGDTLGQEQWRWLEGQLHQSQAETHVIVSSTQVFTKFPVAESWGLLPDAKERLTQLLLATKPKNPIFISGDVHWGGILEADGIVEVTSSSLTHSMYVEFAKIQPVVSFVLQWLNLPIYGYNNFGIIDFEHDDRCERLSRHIKLMDDEGKVVMDTFHDGYEDPMEPYRGVDQKATTFLRNTRIVHCTSLLWKVALISTIAATVYCAFVVAISILRRLFKRRHAKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6U4</accession>
    <name>A0A061D6U4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0301620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768444.1">
        <property type="nucleotide sequence ID" value="XM_012912990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6U4"/>
    <dbReference type="GeneID" id="24564799"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301620"/>
    <dbReference type="OrthoDB" id="370515at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="122" mass="14170" checksum="591D212ECC7DFE6B" modified="2014-09-03" version="1">MTPLRGQLFRAALRPIVLCKHGLNNANIAHFGTLYRKTQEQKTTATQKPKASDYFSRREIAALFLQPLFVIVVYLTVVWHGFKYYCNINSNTDNSHIQIDQFVSTLRWKYRAYRLKQSSGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D731</accession>
    <name>A0A061D731_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="6">2.2.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0304250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768707.1">
        <property type="nucleotide sequence ID" value="XM_012913253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D731"/>
    <dbReference type="STRING" id="5866.A0A061D731"/>
    <dbReference type="GeneID" id="24565062"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304250"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003933">
        <property type="entry name" value="PRK05444.2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="1-D-DEOXYXYLULOSE 5-PHOSPHATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322:SF5">
        <property type="entry name" value="1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596034" description="1-deoxy-D-xylulose-5-phosphate synthase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="14">
        <location>
            <begin position="383"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR96521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="703" mass="76464" checksum="2F1110AB985B37D2" modified="2014-09-03" version="1">MGGYLNVGKSVATLLVLAIVEQCVGISGCVRPDQSAFLVKPQFPRAEQCVSQSARCSRIADHVGGTEAADVGPLDKSRLIDQVNWPEDVKKVPAEQILQLCKELRECFIKNAEQVGGHYSGSLGVVELTVALHRVFDSPKDRIVWDIGHQAYIHKMLTGRRHSMHTIRQPGGLSGFLRRYESPHDLFGAGHSSTSIGALQGIYEGDVVTGQHKDRSYVCIIGDGSMTGGMAMEALNYSAAIRSPLIIIYNDNGQTSLPTGMPAKNGTGPILPYFMVDNTRKTPVSDTEVIKQFDDLSIDGSETPMFLDPIDGHNVEHLSNVLSYLKGQLSADSNWSLKRPIVLHIKTVKGMGSEKALKALDRMHAIKAMAKPNANAAASTPSKTFSEVFADTLIELADRDDSVVAITAAMPGATGVGKLGVKHPNKAFDVGIAEQHAVTFAAGMAVSGAKPFCCLYSTFMQRALDQIIHDVALQNLPVRFVVDRAGYVGEDGASHHGNYDINYLRLMHNMLIMAPSNGVELKMMVNIAYNTDDQPCAIRYPKAAVASQEELDKYFMYTPDEIGSPTSLIEGKKLFKSRCVRLGNMGVAVLAFGPIVLDVMKAVDKIKLDATVVDMRFLNPMDTATIEGILQTHHTVITAEDGVAGGFGSAVLEYLATRPERVDVKCLTYPKQYAHHGSVNDQKRFAEMDEDGIARQIREFISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D782</accession>
    <name>A0A061D782_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768008.1">
        <property type="nucleotide sequence ID" value="XM_012912554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D782"/>
    <dbReference type="STRING" id="5866.A0A061D782"/>
    <dbReference type="GeneID" id="24564363"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209750"/>
    <dbReference type="OMA" id="KVSMLWE"/>
    <dbReference type="OrthoDB" id="364557at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="325" mass="37179" checksum="5DA68B248EE9F339" modified="2014-09-03" version="1">MSNMDAPAPAVLHGDSQRMDTHYSGEKNQHDFFEDLATYIIVNKNDKNCHVAKSQTQAEHKWSEKSTPEDTKPMTVANGNTTPRNQKHSEEDVNDAEGGEADKYKWKPGFCLQLGSQGRKAMLQLLRNVYKSNKKFKHIFEKMDPPTTISNLPFFKVSMLWELAHELGVFDQAIAIHKIYGKVRHKLVKNGAAQGAPFYEGYSPRAAVSRSPKMRRMPNPMYGPPYYNTTNDDERRFYLEHSNNMNQIKRKVEHLVALNKSTPEEYMNGMVPYKQRKCVVGMQPGHVDNNLHAMQMQSNNMYDYIPRMGNQVYSCAALDCGLIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7D3</accession>
    <name>A0A061D7D3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766975.1">
        <property type="nucleotide sequence ID" value="XM_012911521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7D3"/>
    <dbReference type="STRING" id="5866.A0A061D7D3"/>
    <dbReference type="GeneID" id="24563330"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110860"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110860"/>
    <dbReference type="OMA" id="PESCAFI"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="309" mass="33758" checksum="5D7C418C9941F8AF" modified="2014-09-03" version="1">MDTAVQRLVAPPLQNVASNDLCRNVGDVSPYGRRLPRPALFAVDIDGTFLSAEAEVMRKNRAAFANTLKAGFNVFFCTGRPHVSSMAVLDEQFVRSTGYRGYPGVYHNGAVVYDGSGAVLRMNVFGAQFLTVFCEFLVSHQLEKYVAFCDMNGAYMLCDDSSCMKEILADVDMHDPPTVVTPADLLLKKISLLIVHHKEVITQQPHVKCDVDYVLKEGSFGAWDVTPCTSTKAEGLKVLLESYGVTSADCGFIGNGTNDVEAMSLCELSFAVQNAEANVQDFAKYTLAETNEEGAFHTVMKLVYGVPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7D4</accession>
    <name>A0A061D7D4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import receptor subunit TOM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768807.1">
        <property type="nucleotide sequence ID" value="XM_012913353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7D4"/>
    <dbReference type="GeneID" id="24565162"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305240"/>
    <dbReference type="OMA" id="FHYDKEC"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9590" checksum="5445BFE0A25DCDF1" modified="2014-09-03" version="1">MIADAQQSPTFLVRVKRRFATAKRAVVRFTKKTVSYIGWVLWIAGTAAVTLVGPVMFHYDKECQLLEMQHQMLQAQQAANAPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H5</accession>
    <name>A0A061D7H5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765866.1">
        <property type="nucleotide sequence ID" value="XM_012910412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7H5"/>
    <dbReference type="GeneID" id="24562221"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100090"/>
    <dbReference type="OMA" id="RINHIAN"/>
    <dbReference type="OrthoDB" id="365637at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="897" mass="97942" checksum="84A9E6E755D3CBA9" modified="2014-09-03" version="1">MAGTLCSKSAVWRLLHVVAPRKPHMANGIVRRVVAEKIGGGNPLLPLLRVTWDPAGFQQAGECPPGSSAVRHDDETVKYAAVALSHLSKSGFVTVSVHLHRLLDILTNSRDALNRCDARILLGVMEACDRINRACYPVTRRLGDAATTEIVTAVKGNARKCALYICEHVGSTCKGEMLARFAPVMCRMSIVSTDFTKHLLREIREGSSFLSCDSLIGALRYVASASGGDHRGLTGAVYALLDALSVAELTWGRKLEVLDCLVQLKVTHFYFVDVVVSALLESREKDGMSTMGMDTVSSSNLCHVIGALLQLESEHVDTVTEVFVSRYVCQQRSGFEKEGIVRDIRKCSLTDLLNLLNAIVATCPHLEGAARSWAAHIIQDRVPWLLTRASLSELEELFHVLSCVDPAIYSPTLAPSSGAVWRYGAGRANLTSVVTANVGHLGARALAKAIVCYSVAAEVTSSGEAIQEIAACIPRMCSEALAMLSRSSFITKAMAAEMEAPGSEDQKMIVCSPKAPPVAAGNMDAITADSHCRFLYDPSVTSNFKYLKRGDNRVEGRSKAASKLYRTDAAARNLSREVAALPNPDWHNVSMEGHEKNALVEVEGGAYAPTAHEPYSSSASDVLKVLREVHRSLCIYHHFGCGELINPYGGVPLKGLETVKQFLMAHSYLVPVLSARFDALDYQYTLYGVDDGSYNHRILKATRSTDSAYVDPRLMCTPDTHTVREAEYGGEQRLRLPSAKLRNARIGVANPPRSAIKLNWDHFDTSKEAGRAEHPRERRNAAVALHQEAERVSRLVDYRLHGRRDTVEYYDDSVSRRFRGGFACWQDPGDTNTAAHVSCTADGISTSRLHKQVEQTVAVLCPQHVRSEAACGPYHVDLLVEVGGEEHGNQAAPTTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7I9</accession>
    <name>A0A061D7I9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767035.1">
        <property type="nucleotide sequence ID" value="XM_012911581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7I9"/>
    <dbReference type="GeneID" id="24563390"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200060"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="286" mass="30438" checksum="6A36D7604E92DF46" modified="2014-09-03" version="1">MRRVRRSCGIVGSVGVGGLGRGDTGVRVEGSGSGSGTCCSWLRGVGAAVVVLQLAEGIGSGSGTCCSWLRGLGAAVVEGTGREREDGAVDSSVKCIGRCFYCMDFYYKRGSGQAQCHTSGCKGCDIRKCQCDCCEKQKLKDRQQRAASQQLPSSSSHVSSSSRVSSTTVGHQVSGLQPSTSPSDSSSSPSPIPYIIAAVALIIVVICVMIYFRIRPFHRTVMIALMINRMSSEVTITPPYSAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U6</accession>
    <name>A0A061D7U6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0306600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768942.1">
        <property type="nucleotide sequence ID" value="XM_012913488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7U6"/>
    <dbReference type="STRING" id="5866.A0A061D7U6"/>
    <dbReference type="GeneID" id="24565297"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306600"/>
    <dbReference type="OMA" id="FRRHYCY"/>
    <dbReference type="OrthoDB" id="365953at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600128" evidence="7">
        <location>
            <begin position="26"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="396" mass="45780" checksum="3B1F5DD5E28723CF" modified="2014-09-03" version="1">MVRINRKVLCAAAAVAIGLLHSVESQPQSANESDLSGNPSANDNPANVAAPRIEFEPFEDEVDPELEATDEVKVPPKKQELFDMDLMMSPLLSQMPKSFRRHYCYFLFYCVGMLVYGWIGYETNKQRVKRVIAALKPVLQENFAFIADEPHCYEALRWHKFQAYASGRTSCDRLFIDFDLVKRQCMWHRWVFRHMFRMEDTMTIEMMLPKMDCIVFAITHKMTNKLFIKKNQEVANTTYVLDSSELPPTHRAYINGTEKCFAKYASYVIAACQEFMPHLIHFYAADAVPEAEGYRQWRQIVLKVRVGDDDQLAAKVLAAAIHIADYTKNYTVMDKTREAMTKARQDMIAVLFKAEIKRQKEEAKEAKEESKLTPEKIKKLEKKALARPTPRVKVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D813</accession>
    <name>A0A061D813_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0307000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768982.1">
        <property type="nucleotide sequence ID" value="XM_012913528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D813"/>
    <dbReference type="STRING" id="5866.A0A061D813"/>
    <dbReference type="GeneID" id="24565337"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307000"/>
    <dbReference type="OMA" id="CTIMDEP"/>
    <dbReference type="OrthoDB" id="365124at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="254" mass="29397" checksum="A82CF230DCCF2A92" modified="2014-09-03" version="1">MGEEHFWVPPLFFVLLVIYTIAMKLWLVRVNRLFVQQLLSEFDGDGVPTVTFVLAHPTDETYFFTPTFEVLTRSPYVAQHELKIRLLVLSKGKYVGRGDERTFEMEAVCNMYNVLCTIMDEPYTQEGPQFWDTEQIATQVEDFLKQHESQVVITFDQYGADSDPNHISTFHAVNSLKEKMPDLRIWALRTYGVLTTYSAPFALTRATVARPSATTFTFSSTNRNSRLHVSSWTWKTPFHTFFSSYSYANSYLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D832</accession>
    <name>A0A061D832_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767270.1">
        <property type="nucleotide sequence ID" value="XM_012911816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D832"/>
    <dbReference type="GeneID" id="24563625"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202410"/>
    <dbReference type="OMA" id="TEWSLQK"/>
    <dbReference type="OrthoDB" id="364981at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="360" mass="39891" checksum="BD069D90F617FB82" modified="2014-09-03" version="1">MELQITGPFNQLSTEDLEVLDDVAQTFCEAVDIVLKTNFKSQKRDASHLDSATRSTAARVEEPTKNQKIAAVFCRQWLAAVLSELTHHLAEAGSDRFNHEAAANIASPRMLEEGADASGTDDIGLCIENARICGNGQIEVNYELDPSQVPQHLKPKLKAQELMQLILQGKQTEQELTQKLEHFWLNVPSLLCQYLDREEDEEARGDDENRDEQPAAADHTDAHEGSDAEAAGDVNNEESQTTQQLQQQQSSEPATAVQAAEEEEMDGQVPFDEEAIELLENIARGFANPLAPEHVPGEDVQQKLAQIAERSKELGVHGMDTYIALYNKVNKEIANVKKMAKFFAKLATDVSRSRGQIDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D885</accession>
    <name>A0A061D885_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0102680</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">COPII-coated vesicle membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766126.1">
        <property type="nucleotide sequence ID" value="XM_012910672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D885"/>
    <dbReference type="STRING" id="5866.A0A061D885"/>
    <dbReference type="GeneID" id="24562481"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102680"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000005">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000041">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000043">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="128"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="387"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="524"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="638"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR93940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="770" mass="85900" checksum="898641AC8AC235EA" modified="2014-09-03" version="1">MDFTGLEAATGLRFSWNVWPCSPEEAAKVEVPVGCLFTPLKPADPEGNAKIPVVDYSPVRCRSSGVFLNPYCHIDFRGKTWTCPITMQRSPLPPSHAEHISPENLPLELVNLTMEYIIPTSVSGGLFPPTFVFLVDTCVPEEELEQLKDSLQQVVSMLPQDVQIGLITYGSVIKIHDLSDSEIPRSHVLRGTHHHDAEYLKKILNLAQQHQRFVQPLSQCEYMFNTFLDQLVPDAWPVAQNSRQNRCTGAALSAAVALMEVACPNRGARAMLFTGGACTLGPGKVVDLSLTESIRHHLDLQKEHHNARFVKDALTFYTTVANRCAKNAHAIDIFACSLDQSGLYEMKVCCDKTGGYMVMSDSFSMNVFKDSLKTVFSLDSTGNLKQGYCAKIEVFCTKELQVSGVMGGCSSTNKKGPNVSPNVIGEGGTTEWVVGAIDPKSTLAFYFDVTDGSSTATSLLSNAISTIGASKKDKFAPAENAGKTAFIQFQTMYIHSSGQKRLRVTSFSCKYAQPNIAHLAPTFDQEAAAVLMARYAFYKSETEDSIAVLRWLDKSLISLIAKFADYQKNDVHTFRLANEFSIYPQFMYHLRRSHFLQTFNASPDETAFYRTVFMRENVINSLIMIQPALLEYSFEKPTPHPVLLDACSLKQNVILMLDSFFYVIIWYGDMIHQWREQGFQDKPDYAHFKELLQAPASDANHILSERFPTPKFILCNQGGSQARFLLAKVNPSQTHKSGYGDYPEDTQVVNTDDVSLKTFMEHLVKLVVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8D4</accession>
    <name>A0A061D8D4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768423.1">
        <property type="nucleotide sequence ID" value="XM_012912969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8D4"/>
    <dbReference type="GeneID" id="24564778"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301410"/>
    <dbReference type="OrthoDB" id="366420at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="606" mass="68199" checksum="54948BDD6F83B3EA" modified="2014-09-03" version="1">MKLESITFGGSPPTKTNKPKNWFGRVAFAKILVIILSLSLYAPCGCVENASDSGKSRNNLTNLHGDGENVASCQIGDVAGRICEVQTQYGDGVQIQGIIRNANLTTSISEGKSVHQSPNTNDPAAPKESCSSGWIKPCEIEQDGEDAQRFAHANVQNAVRSEGQVKSSGEKHHGTDGFRTLNEHSRAFKMGCDDHRGLLSSITLAKLPRALYVAYRAPFVILKHHFRICAQLEESLVWGFNHYVQEPLIGLYKSFRYTLYPCGINIVHTALARLTVQLKAQALLKDEYMTMNANLEAFMRDEHNIHQQAFISKDAKPFSIKNIAALLHRTTGIKHCIYWWHAISRNPRRHIQGNYTLPKLLMAIYGNQIRLLIKDCEVYVLWLTFSTGYLFLGNVNYSADIHDVEDAVKNIFGSFAPSPFAVKRCWAAVSDAITHVIAFVDHKMERGYGYMASVYPDFELLHPRSQMERVGVTLALAFLVYTVVWFIFAAVRGILGIIRFVVSSIITLGFVYVAYDRLKIWYDNSFLRWSFDLLQTQKNYSKSQSVTKTRMKTKSIYAGSSQTDHPSVNRRKGADGSKKSVTLWHSVSRRNRLADTVIVNESNKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8H8</accession>
    <name>A0A061D8H8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NifU-like domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768989.1">
        <property type="nucleotide sequence ID" value="XM_012913535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8H8"/>
    <dbReference type="STRING" id="5866.A0A061D8H8"/>
    <dbReference type="GeneID" id="24565344"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307070"/>
    <dbReference type="OMA" id="CHYLDDV"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU C-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="154" mass="17279" checksum="3F442CA86DF2B602" modified="2014-09-03" version="1">MWILSRSLPRLFTQACRSRCRALPCHVPPTSARHFGPSCEFRRRFSDRARAVIPSSYSEKDLEVVESIQLLLEKRIRPVVQQDGGDVTFVSYDPETGFVYVRLSGACVGCAQSDVTLKHMIQGMLCHYLDDVAAVLNCDEEGFVVSGETDDSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8J1</accession>
    <name>A0A061D8J1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766251.1">
        <property type="nucleotide sequence ID" value="XM_012910797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8J1"/>
    <dbReference type="STRING" id="5866.A0A061D8J1"/>
    <dbReference type="GeneID" id="24562606"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103790"/>
    <dbReference type="OMA" id="KAISKTW"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595564" evidence="2">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="237" mass="25631" checksum="262DA16525BE3DBF" modified="2014-09-03" version="1">MKAFTAIVACLGAAIAVCAENASDLHVETDASSVVQLTDSNFEKLTQATTGSTTGAFTAGSGLHTAGPWFVKFYAPWCSHCRHMAPAWERLARELKGVVNVADLDATRSPNVAKRFGIKGYPTLILIDKGRMYVYKGGERTTERLAAFATSEYQKTISTVVPAPLTRLGMLVDFMITGVQEAQRIYDVAFRGFFIVSSFSLLFGLVIGMICCVILLSKSTTTTPVGKPTKISARKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8K8</accession>
    <name>A0A061D8K8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0309490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769232.1">
        <property type="nucleotide sequence ID" value="XM_012913778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8K8"/>
    <dbReference type="STRING" id="5866.A0A061D8K8"/>
    <dbReference type="GeneID" id="24565587"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309490"/>
    <dbReference type="OrthoDB" id="378109at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="6">
        <location>
            <begin position="387"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="824" mass="91076" checksum="8909A7C3CC5DBCEE" modified="2014-09-03" version="1">MSSRAKDTNMFLVHGKNGLFVNGCVPGRRAETPSEYAADADESARSDTTTPYTSVTVWSLNRFARHYARSPNNNVAIVDDRLGLSILHVKGESPSDFSFDTLRGVGKYRNLYTPIGCKNIKHLQWSNNGVYLVIYFNLTNCSRETGLFLEDNLHIWDISQKCIVGSFSTRRLSPDQWPIIKWVGHSDKFALCYGQQVSIYAITSSENTPLKSTRLLHSIPIPRVFSVEVFSPECLPDSNDQSKGEVLGTDRKGGAVPGGKAEHTSGLSLGERSGTDATTVGSFAATSDRDDASSVAPGDVVGSAADLRADTPSAKESSATSPRSIAGSESKSLARFCRGAQDCTISIAAYTKADVSSQISGNLRITTLRCVGDELSELSSVDHELKSEDSADMFWSPSGRSLLVLGQSIVDLAGEKYGSTSNCFLFRSSGDFVCQVNMQTTHDARWCPTRDEFILMEGNMPCDITLYDSDCVQLFTFPKSYRNTIKWNPLGNMVALCGFGNLAGEICFWYRKDACDYEQIVHLKEPCTVVSEWSSDSRYFMAASTFPRMKVDNFLKIFSHEGDLLESQKFDECYGVCWMDHPDSDWEFVRPNVRQSAQRKAVYRPKILNKGGISRRTSEGYGTRSLLGSDAFSRDGRTTAMPTPSQDGVRAPAPAEGVRQYAMWNSMMPTNGHSKPTNSVAMPRSARSRSYRGSLFSTDYGDKNDPTIDLMNAFRNVFSLSQFRPPPQPASYENANAPRFPHDCLGDYPHLPLGRRTAQARGGSGSASSNQDDASRRLAMLMRIKSQMQCEKSKPLQQTVLDEVQLLKLLLEAKNRSLNRARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8R8</accession>
    <name>A0A061D8R8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766326.1">
        <property type="nucleotide sequence ID" value="XM_012910872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8R8"/>
    <dbReference type="GeneID" id="24562681"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104490"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7966" checksum="08B14CDD03C04401" modified="2014-09-03" version="1">MSKKYANISDPVISCKRLSEAVVKVCRYPNGKKMGLWMQYITTRQHPNRVLLQTLHNTDNYVTIRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8S8</accession>
    <name>A0A061D8S8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0302660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768548.1">
        <property type="nucleotide sequence ID" value="XM_012913094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8S8"/>
    <dbReference type="STRING" id="5866.A0A061D8S8"/>
    <dbReference type="GeneID" id="24564903"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302660"/>
    <dbReference type="OMA" id="KFELMCK"/>
    <dbReference type="OrthoDB" id="10250004at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="574" mass="62501" checksum="2E4060D6EFB3ECD5" modified="2014-09-03" version="1">MSLITIAIGQGGLGLHSAFMQYAADYIAELRDAPSDKAGIEHKSKTEFATALDMSYFGGKRETEEETLLPRSIVMATGTDVSEALYRVQHGEIAKHSMINNNRNSAKGASNSSSRGWKYEEDYVLHLPEASHDVWSRGFTNATIHEESISEVIRKCMEETDAPGGFVSFVSLGGGSGSGIGAYVARLLSDQFPKIIHMPAAIAPFTYGESGMQSVNTTMALSYYQDFCDGILLLQNDIQASLCAKVFGVGGNSFDCLNMLTATNIFHGLRPTSSTCPISGSVRFGNSLNFITDGLCSYPSMKILNLDLLPLERLDGVKKNAVSIHQIASQLADRLKADPTLVEGLNNEKVSLIAKDSTPQDPGTGAKQRGSQGLKEQIIIKDFSNYEKTEISQSDTKDSFKCLRHLPVKSPECKHIEITENGISLVDTPSAEAKQTTSNSFKLIKTVGKKRTNVTKFNVVAGVQVNIGGHINENVNLVDLYQDVLFWKQSTRPLQVSYCPSDVGLLGSTMSQISNSQAVVPFLDFTVTTAKMCYATNTYMHKFNEDGISTEELQHGIINLQELTGSYKAMSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9A4</accession>
    <name>A0A061D9A4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pumilio-family RNA binding repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0304700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768753.1">
        <property type="nucleotide sequence ID" value="XM_012913299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9A4"/>
    <dbReference type="STRING" id="5866.A0A061D9A4"/>
    <dbReference type="GeneID" id="24565108"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304700"/>
    <dbReference type="OMA" id="FIENPHF"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="587" mass="65830" checksum="FE41361923B2AB95" modified="2014-09-03" version="1">MLSFVEAEMYLRSLREGIAKVQEDSTASEKYLLASNAFSQIQDHIPKLAAHQVLSRYVEKLIALLAHSLIEDPANELEEKRQLCESICLHLMMKGDVTTLSMDSFGSHVLQSALQCGTIFEHQGFSLSTPLQYFAAAVEDGCLFQMLHHPSGSHVLRSLIKAIACALDADAFQSSRKWRFARLERWADLFCLDLGGSLSTTQSSITVCVVLKMCQSRPGSNVSRLCNSVSEYCVTHCTESKAVSYAAQECLQLCSNEEFNRVFNILVATRAQELSEHAFGNYVVQSVICHRYFQQSHLERLLNSIDMGKLLLSSSASVVWRMCESAVTLGTCQALFVKKLMAALRISNYTVNDSKKKRAKEKKRKAKEELRSDGAASADAADDRGAQPVEETQSGDESGAHSFKGHLWLALTSCTRPEKNHIHLRAAGASILLHMLKFERKLIVNLLSDFKYFLRIAKSHGRIVDLATDRHYSRVLQLMLDRRQGLMTEKQVRRLFKYLKPHLFDIAMDINGAFVLSDLFQASPLQLRRALLTGLAPHSKEIIDRNKKFASIICLDAFCKSESAWTKHQTVAESVRTLFKDIINPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9B5</accession>
    <name>A0A061D9B5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768768.1">
        <property type="nucleotide sequence ID" value="XM_012913314.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D9B5"/>
    <dbReference type="GeneID" id="24565123"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304850"/>
    <dbReference type="OMA" id="CAHEFEY"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_119, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="516"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1711"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1552"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1834" mass="206377" checksum="EC4868447B6D0350" modified="2014-09-03" version="1">MQLIKIPGINLDVFSKGVNKQGGSEGHATEADNGGDGDKSPSQAANAPTADSTTATGEGMQGKEFPPDVDEDLAGHELLWSTQYTYEEFIDSLSVAHEGRGETAKEKRHWSYPRRWLVKLHNLKIVNCISDSLTCFAEFDFGGSRSECRVQMGSSVCILNRGETKNYIRTTVVRNVTKDVPRSFNCAHEFEYRGSYLDLEYEKLKIKLWQYRTTNLNGLESIYEGQLLQFAKGDTHVEIPMYKGLNKQRRLRCRISFDLYFQELYDFELSFISWRLADCPSFLDLLYKSKEAIENVKAAAKDADGKDKQRAKGNSNISFSIFDKMIYYFMRKRIERDFKKSAHIRRETTGNIPTAEVPVEVETLDPYMTLLRDQKDIAFHSNTVPQTKNRETSVKLRLHIKTDSAFRHATYLQLSSIVSKNTRDVYWENMGEIIFRGTLLDLERAELEIDIIDVNAPKAVRKIGHVVLPLAGIVDYPYLRSQLSKPKWLTLKANMEGWGSVLERMNFGTLSGKIKIQHKPRYRQLTNPSGLTLYSYPIMLIVTIGSVDQLILDDDNACIDSYVEVTYNRWTYRTFRCKNSRAPVWNEDILIPFLSNDDERINCSVILQSSPVRFTIWGCSNRDNKVTYLGGTMLYPYEIFYTPKGSLKQRVKKTYAENGQYGNLYESRVFDTRVFNGPLKLSFLNNDERQSNLTVSAWLYPDMPDESMPDQFDIKRLRTDQIVLPSFQMTTVYPRLLDYWQSVVDMKFKPIFKNIGSISVECATQTHPRVYLPCLITPMHPPMGIDTPNAVFHMIRCLPFVKRTYDTKFTADFLMKLKAGNAFDHCVLQCSYLRGLTPPVEAFICVGFTQDGRQHSWVASIHPDLNRTVKMWESTTGDIHILKNRLVSEEDENDPVSDRRLRLKLNSKFPYTKLIYMFNERNVWLNVQGFSDPQLLLFDVDNPELWYPFVPNNPFHQPVHVPHISYERLNEYEIQRVAHDLEQSLERNLTIHRYAQNLQTRWNKDEALHRFLLTGLKLLHQINTCPDVDTQLAKCELHEWKLMLNKNIPQSHQVVVVPLHFNVVDADFIAENIKTKVPLLDSRERFITFAMASWVISIPGSLFSVYVILLVAQKIHERVRIRLVMEQERLAQRKRKKKSASTMDEDSNDIMNREDSLNDSLKAALESNLELSGEYSEPSKQFSSLMEQIDHNLAHQDDQLTKLYTRALTKAAAAVTQQPTQYMTKDLSSSLGESMSSDVVNDLISDESSSLHSSSSSIAIDFANLGSSPQFSSRDEMVGGMSEEQSHTNTHDTLSSAGSISALDSGTDDIMKAPSYIYNRESSGSQPSVDVRKGNKYKSGSLKSTSINPNLISRESFLQTSSVSSFDSGFDIGSGTFDESDPDEPRDATSAFSDETRSDKGMLLTEDEALASGASNLVSPHVSPTASESLSSVGDPLFGGVDRIYSALQSMSSYGQSATVSINGDSSNESITVLSSGRMDSGTRSDMSRDVHAALSSDGSYVAEKPQRRGSARRFLDSLTKMTSRVMSRSSGHGNSSESGADTLRRSTESDTLLDDDDDDWSDSIVSSFTESASVSNANSSRMSDNSSRVSDVTYQLDSEPSARPQPVEESPVSSALVSRSNTTTDITMSSSTFSNLASSVSISNSEHSANLESTYEDESATTQRSVHEEPQAAPKAESIKPAVVDTPSVLPRIERRGRLKTIGNIRESMDTHRSITESTPSDAAPASTGGSFFSQDSQEYSSTSFTDLDAYSTVSSDGSSSTNKVSFAETATIYSRDKGVTQVPTLQSDTPSQRLARSLFNKSKVRTKEWETPPQKTHAVCDFKYVDLFRGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C4</accession>
    <name>A0A061D9C4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0304950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768778.1">
        <property type="nucleotide sequence ID" value="XM_012913324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9C4"/>
    <dbReference type="GeneID" id="24565133"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304950"/>
    <dbReference type="OrthoDB" id="10505568at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16804" checksum="2DCA4079DE3965AA" modified="2014-09-03" version="1">MTNVTTRLLINRFDSDQSVEEVELDHQEPISSVKERLFAEDITNHHKIRIIHGGRPLSDDTVPSGLRGYKAGEKLVLTVFITKPDTLEPEAESGTCGNGARPHGLWLWRRCGATNLSSRTRSGGSHCLCYTLQRLYACTWFFRALSTSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9D9</accession>
    <name>A0A061D9D9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767730.1">
        <property type="nucleotide sequence ID" value="XM_012912276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9D9"/>
    <dbReference type="GeneID" id="24564085"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207020"/>
    <dbReference type="OrthoDB" id="10468705at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600714" evidence="1">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="194" mass="21528" checksum="2D4D1E08228BC556" modified="2014-09-03" version="1">MSSLIVFLVIFSAPNAFAGNLRENEVASVGETHMTYSMWLKLCETSEKRFKERQDEAVVESASVAKSSKGSVVQAFESFKARVSKVTISCQQLVSLPNTPTQLAFKGQPDEANELDKSARFIGRQIMHAIISAQNQYIIYKVVLNSDKENPNYVDAADVIEKYVLHLNVISSSIDKVKNFLLVPAVLAIHSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K0</accession>
    <name>A0A061D9K0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769532.1">
        <property type="nucleotide sequence ID" value="XM_012914078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9K0"/>
    <dbReference type="GeneID" id="24565887"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312490"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="532" mass="59303" checksum="6BCBACE9BE425E8A" modified="2014-09-03" version="1">MKPLGYFVPQAIAALMFSWVTVFNESPISALPTNGDSGGEDHPLEGIAFYAEDEEFYRKVKILVTLTRPDGVLFGFFETLPSLLSASEATPEVKEAAIHECRQLLNAVQDVTGRYIYFADLKNILDKYRVVSRGLKRKNLTPELSAKLRSALENLTEQFKGNERTASGIFQFYNASKYRETIRQAQLFIQKYTGYTQTAPEHNIPGSSVRSRLNQAVNTADFVKNTGMIPSDVPQSYLSSDEGNETMRVLLNDREILQTLHEIQAMANKIEEILHEPLMNDINFYAAGSPPILNTELILKFQEHYDKLYDTLRDIRYAWPIHKRYNDINDMLKVIDPQSPQASELIREQRQLEISFEEYGPVVVTMSAKYVKLNTADILTMLEKIEKERKPAQLESTVPTASPQDTPPSSAAYVPKESTSLPQSKESSNTTAPTILSLGEGAGLPLTKERGETITTSKISKTICDEPSQMQNAQKPSITESGASGESSSEQPAEKIALRVNVINLYKRSSGFLTTAITVIRTMVAVGVIAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9L5</accession>
    <name>A0A061D9L5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0107240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766601.1">
        <property type="nucleotide sequence ID" value="XM_012911147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9L5"/>
    <dbReference type="STRING" id="5866.A0A061D9L5"/>
    <dbReference type="GeneID" id="24562956"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107240"/>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="92" mass="10825" checksum="0E142B8148BF9C29" modified="2014-09-03" version="1">MSQTPMLGPEFGHLTPAQRTRVMDHLTEMQYRDTLETYNGMVDRCFNECIVSFRSKDLDSRETSCINSCVKFFFEFSQRVGQRFAEKQQNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9M3</accession>
    <name>A0A061D9M3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CERLI1-like PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769419.1">
        <property type="nucleotide sequence ID" value="XM_012913965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9M3"/>
    <dbReference type="STRING" id="5866.A0A061D9M3"/>
    <dbReference type="GeneID" id="24565774"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311360"/>
    <dbReference type="OMA" id="IHHINLK"/>
    <dbReference type="OrthoDB" id="359169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056293">
        <property type="entry name" value="PH_CERLI1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23634">
        <property type="entry name" value="PH_CERLI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CERLI1-like PH" evidence="1">
        <location>
            <begin position="222"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="413" mass="47124" checksum="CD06E0AF12E17ECA" modified="2014-09-03" version="1">MFFIDPQTVGCCAIGCCGVAAASYVSNNLAKIPHPSECGCIGSLYRITGLHSHDSFDFILEIHEAVGGVGSGNYFFEVEAGRMKYRTQTLPAKDGQLQVHEKLKVHVRQCDDTVVVNLYRSQLLRSDQCGELKFSVEQDLMAPKPAKRRWFTMVHQNRTATRVKVSIYCMSDEMASRNLSALTLQAIVESQQDGSNLEEELVEELENMDDYAKLRFYSKVLSGPLKKMNTFGQKWTTYYFKPLEISAGNWEWCVWNSIEDYNAGLEAIEAYPFLAMSVVLADPTNAACFYVKYHKDGNDFGILLKRIDRNRDLWSDSLYEFIEKTREVYFRTPNKERIKISHKKIKRCKDLEVFCQQSTDDEKRTELKAKLALSKRLTSPMERAEANEETKLPDAIAKMALNMYVEECNAGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9V2</accession>
    <name>A0A061D9V2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0313880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769672.1">
        <property type="nucleotide sequence ID" value="XM_012914218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24566027"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313880"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1800"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="1697"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1697"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1862" mass="209203" checksum="C3A802A6398D4AE3" modified="2014-09-03" version="1">MVMVLPTLKKLIDDAINNAEKSLNAEKSKLECPVKYKGNESTCQHFQKLIDQHEKSDPSQKSKNESNLELYKNAVNSCSDSHSRNQDSATKKALQDIEEREKQLKDLESKLSIFTEKNKSDDCKKLLENLCTGLEKFLGFNSDSKGYTGQGIVYSDLDRLCDAVVAFLYQVLKDVSEKQPYKVGKEKLNEAVEMLNNNLSTGREGFKVIEQVARKVREYNESVKESNKKVRDPISTLQDKMGELKTAGHDFTGEKTQVDEQLQKCKQYAKNFNDTYNLDDNDFNIDMRTSINDLNDRLRDSVLVALNAVQHETDRLTALTDKERMDWQGLYYKIQKILTNLEKSIGIKIKEDIERYVYYLRFKVKDMKNHLEIIQHALKNYLLDLQKWIHVSDEIVKTAWRRVETILEKVDGGNAHNKKDIVKVSKDIGEQVGKLHKQFTDLKVKYNDVCELIKGKDGLGAKGENGGVLGRLKKLHETVEEAVPKRLSGFVRSADGWLLSDIESFKGTIATNVKTHVGGMLGGINKLVEGIKGANENGGLKKVEAEVKKWAADFNGADKFGEQVEKWVADILDKDEIVKKLIKTYVRVDLDVKRANVAAVFKSHLNANFIQEAGKKIEEGIQGLNGETNVGKIKGHVEVVHSGIDMFVQRLGQRIKQVESDSGDTFVKNIATQIHNDDGIMIQPKKSVNPTIQFINAVKYTLNQLVGIARKHSVDLKWLISEGDKEGNLKKVDDALGVATNLYDSLTEAVEAATNPGAPQPSEGSFAQGVKQIAAKVSDADAQLGTLLYEAVKKGIDKLQAALEEPVISKLKHIDNNLIGLGIIAVQAKDEISRNACAITDSLDAMCDAIKHLAETDKDSAKNKLNELRIAIGHTVTGDKESLQQLHSQLSRLQSVDLQNAIHSATDFVDSIADREKTTVIRQLKEHIYNLFRDTNDALTIEARKNYVSSIKLLVEQFVNKVADVLKPLPGYINKDLEVGFKGFMKTFGDMFTSHVVTHNDDLKFEGLSFAFARFWGPVKDYVQKEIKTVGKYINAENDDLLPELQDPYSTRLEAASTLLHDLLGHFCATHNYDHNVPNKLDKLTDALAYLTPECFSKITTPTLDCICLGLNAFMIEMRKAYISRYDGCKAINDWLMDGPKKAEQKTKDTADDNKILTTDGRNGARVCVTVVYTLYQYLYELFYTGARNWKKYTIKGEDAKYDNALQKYLKRSGYELCNLDSTLTTLGVTGRLFNGFKPYGEFNKDPSEFKNMEACADYFRKQEGPVVRLFNFLETYNEMCHFTHISKPRSPCNVYEMCIWLTGLSYRRVYDSLLHDVLPSLLEDPNADDAGDEEITVTDTAVDSLAAYPQPIRYNDIANALTHICSKSYDVITTVVGHGDAETHYASEYCDNSFKLRYPTDPSACLDMLLDILRRLFAVFNFLQRQCSLTVQHNGWRDCYYGRDVNTSKQPCKVHLKCKPTCQPNSQPKCQATCEPNCQPTSPLQSYLNDCLPGHLPHQITDVGCSYKCSSCSNSTPGMPCLTPLGFRAFSGSTKTGRDICDILEEFFCHVKTTSLFCLQPKPPKTLAEHLSFSLSLAKQWQSNRKHGLKDKIHSSIDKVSISLCKTPHGFTSAISSAYGSSQSDHGAFHPSAESADVSSLSMQIKCSGNQCAPYLYSLYDDVYSHIALKNSGACLSWALYLPWDFHNYLQNLLKAFKEIFCQDWGCRGCLRADSCKRGSHGEAKPPCHCTSIVDCKGVSSTLYNYGFAFGNASALCAKQSAKTCSDFCSQLKNVLNSEYFKKLFEACDEFLWIIRQPFSYLVLALWLLSFLYLLHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLGRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA09</accession>
    <name>A0A061DA09_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0208980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767930.1">
        <property type="nucleotide sequence ID" value="XM_012912476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA09"/>
    <dbReference type="STRING" id="5866.A0A061DA09"/>
    <dbReference type="GeneID" id="24564285"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208980"/>
    <dbReference type="OMA" id="FMVDILN"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="652"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="857" mass="97970" checksum="B76DDF9570C48D89" modified="2014-09-03" version="1">MAARSRKGDPTDDPRFKTQKQKSRKSLRKAQRKADKQRHHQNMIQWKQRRSSKSTHQETASHQEENVKSQKRKMSHKNEVIPPTNHPEEKSYDELEIEYLERKLRKNRKSSAKSGDLFQSLKNEFVNDGFDEEFLDFLSELSNMAEKGKKAKGSSAVSKAQKKTGSGKSQSRDEDEDIEDDDDDEEEEEEEEEDLDDDDDEEEEEEEDLDDDEDVDDDDEEEDDDDEEEDDDDEEEDLDDDDDDDDDDDDDDGDVDDEEEESEDLDEDEKDEEDEESEEDVKINKRVRFDLPPKIIKGKSSHVTVYMRAGKSKAKEETRKKQAKTVPIDGTLVEDMKKKQRGFLNRISEGNFTIVVKEIIKLYNQMLSSASNDGGKERLLLAVDELIDDLCECTVKMVIENESSVISLVAMHTALICALCNTVGINVGYVYCHKLLKTLEAALPVLFENHDGKELSYAKLVTRNSVMSFAVISHLDMLDLDIIFFLIKNISRENITEHVAQILMVLLRYTGHKMKVENPSSFHNVIGHLKKLLDKYKETHGDITQSRLRFFEQEIESFKLSKEKKPLETFDYLKNIIKGEFRHRAGTTNPQINLQTLLKYTKESDEAALPSHAILHKLDTASLMAVKSTKMDGANSTESLLQKAAALRLYSNCQKSTFVAIMGAISPQHAVERIMELGIKPAQYTEVVYTVVHSLMSEKLYNEYYTEVSKNLARLPAATGKRFTRACVCTLISVIEHLHEKKPRKCAHIGRFFAAMVAGKVLELKLLKFVKKEHIDSDSVEAFLKNLFACLVTMTPASSEEHVIAQLMSLANVEMFDIFCELWLEYLRDHCMEKVLGSGTGNVLMEACRRIFGAKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA53</accession>
    <name>A0A061DA53_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0109230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766811.1">
        <property type="nucleotide sequence ID" value="XM_012911357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA53"/>
    <dbReference type="GeneID" id="24563166"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109230"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="183" mass="20370" checksum="D0BF1FE5788FA02D" modified="2014-09-03" version="1">MSGRRIVYGQACTRCKYGCKYIEVCNCCPWCCEECNKSTYESCDICYIDFHYKFQVKKDCHYKGCNSQTITCTNPKCQCTCCKAKCARGEIPTCSLPPPPPPLPSPGAEPEYASQKLSSPPDALKQETDAPPSPPPYTTIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPLCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAB6</accession>
    <name>A0A061DAB6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0109780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766866.1">
        <property type="nucleotide sequence ID" value="XM_012911412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAB6"/>
    <dbReference type="STRING" id="5866.A0A061DAB6"/>
    <dbReference type="GeneID" id="24563221"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109780"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="446" mass="49302" checksum="6179AF5D69980EED" modified="2014-09-03" version="1">MALKATTLSAAQRFVRGFMPYLDNTGSPAHSVVELEKYLKDNHPSAQRLDQFAPWVLEKGNTYYVADANATMMAFHVGKKFNAEKGGLLITAGHTDSPALKLEYKCESTAHAFNQAVSLTYTSGLWHTWLDRDLGLAGRVIVRKNGLLEEKLVRIAKPLIVVPNLSVHLQHSAEREVLKLNREKHLRGIVSTEAVHKLNSKSSKPILAYVAKEIGVKEEDIVDMDLCLMDNAKSALSGLYEEFLSCARLDNLASCFGAMGGFIDFVNGKEAEESEFVTCIMLYNYEEMGSQMSSGADSQVTVEWIDKVYASLGASLGKTKDRALILNVDMSHAIHPNYPERHSDTHQPHFHEGLVMKRNVNGRYATELRAAAVIIETARSCDVPVQDFRVQNDSPCGSTVGPFLSSRLCVPVVDVGIPQLAMHSIREVCSTVDIWHLKEVVNVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAC6</accession>
    <name>A0A061DAC6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0308310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769113.1">
        <property type="nucleotide sequence ID" value="XM_012913659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAC6"/>
    <dbReference type="STRING" id="5866.A0A061DAC6"/>
    <dbReference type="GeneID" id="24565468"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308310"/>
    <dbReference type="OMA" id="KYHERAR"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="397" mass="44992" checksum="EB3EDD4592A14159" modified="2014-09-03" version="1">MARKKNWKRIDVSTVHESIVENNIAKSVARDGISDKIEIDVVGATPSKKLAKKIKAQQAAGPLAARGAVEKAKLRKLVEKIKQKNEAIEVETDESDGRRKRESDDIWSEDTEHFVKRRPKMPNLAKVIPAVAAPHAGQSYNPTPEAHAELVDQAVQALPKEELESDYPLTDLIAKALPALEVEQLSFIQKQKLAHLVVQNNVSEEAIMEVLQEPPEDGDEEDDDDDDDDDEEGKQEGRSRANRLKKKTRAKRNRIKQHKETMRQAQMRKRVKQLVHDIRSMKKEDVTAEETSANREGMEERLRRYLAGLVQGKNVPRFGNKVYRADPPPVALSDEMKACLRQLQTPTKSPVDHVLDSIYRRGLVPAPPVIDDKYHERARKRVIKHAVKFKSKLLQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAI8</accession>
    <name>A0A061DAI8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766921.1">
        <property type="nucleotide sequence ID" value="XM_012911467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAI8"/>
    <dbReference type="GeneID" id="24563276"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110330"/>
    <dbReference type="OrthoDB" id="361431at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="117" mass="12797" checksum="7A276BB9344D491B" modified="2014-09-03" version="1">MRPEVAASGEEASFPAVRTLRFTVDGAGDSKREYEAVAVQFANAWQLFLTHSGKVGTWLCASADAPHADVYSVKTLIGDRLQEHLAVYARSLVKTLCDSLRTRSSLELDREFAPPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAN4</accession>
    <name>A0A061DAN4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0309500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769233.1">
        <property type="nucleotide sequence ID" value="XM_012913779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAN4"/>
    <dbReference type="STRING" id="5866.A0A061DAN4"/>
    <dbReference type="GeneID" id="24565588"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309500"/>
    <dbReference type="OMA" id="TLWRGAI"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR97047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="304" mass="33185" checksum="02C3A86B671179A0" modified="2014-09-03" version="1">MDKYNLDFLPPAARPIVKPCLPFILGGASGCLATVCIQPIDMVKVRIQLAASAGQTKISPVALFGQIVKNEGLKSMYKGLDAACARQILYTTTRLGLFRTISDKLKEKQGKDTLPFSQKCAVGLFSGAVGAFIGNPADLALVRMQSNQSLPLAQRKNYSGILSTVCHITKNEGVTSLWKGSTPTIVRAMALNVAMLATYDQAKEGLSPYIKSKSMLSVVSSGISAYFAVLASLPFDYVKTCLQKQNSGGPQYKGVTDCFIKTYKQGGIRLFYASYSAFYMRIAPHIIITLLLREYFEHLLLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAN8</accession>
    <name>A0A061DAN8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">REPLICATION FACTOR A 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0309550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769238.1">
        <property type="nucleotide sequence ID" value="XM_012913784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAN8"/>
    <dbReference type="STRING" id="5866.A0A061DAN8"/>
    <dbReference type="GeneID" id="24565593"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309550"/>
    <dbReference type="OMA" id="VIRAVFW"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003871">
        <property type="entry name" value="RFA1B/D_OB_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02721">
        <property type="entry name" value="DUF223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A 70 kDa DNA-binding subunit B/D first OB fold" evidence="6">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="8">
        <location>
            <begin position="136"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="7">
        <location>
            <begin position="303"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="460" mass="52735" checksum="A6D09002633F2FD2" modified="2014-09-03" version="1">MELEYFPIKNLTTYTSNWTIKARILEKAPLRQIKGDNHLMHIDVVDKHGDSIRVKFWGKAATKWDEVLQKGKVYTFSKGTVELSNKRFNTTPHNYEITCHQESIIESVEDAGDIKLQRDHKLLTLRDIKTMPNVTQAPVDLLCIVNAVQPAANVTTKAGKEISKRVVMLVDDTGYEMELTLWAEHANNEAVEQMEGKAVIAEKVIIREWQGARSCQTLSSSEVQLATQDNIRDHTRLSQLQKWFEDAKAKNETFKTMRPQAVSARDQYELADMVTVADKTKGGYIVKGKLRKIFWKNKDGVAKMWYQACPMCTKKVIMDGDDNRYKCISCGDATVVPVPRYMFYCNFTDHTGRLTAQIATDIGEKLLGKTAKELEEMDPDKLKRFCDFEATHRDYKVSGYIKTRVYNGETKHNFTVTRVEPLDYAAEAALMLENMRITYDDVLKFLDIKTDERDSKKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAS9</accession>
    <name>A0A061DAS9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768210.1">
        <property type="nucleotide sequence ID" value="XM_012912756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAS9"/>
    <dbReference type="STRING" id="5866.A0A061DAS9"/>
    <dbReference type="GeneID" id="24564565"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211665"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211665"/>
    <dbReference type="OMA" id="DWEIKFA"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="1">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="259" mass="29096" checksum="FFA26288C9101CA3" modified="2014-09-03" version="1">MYTSKFEPPSFGPSNLKYEKLISANLKHIQAEILYTEHNVGDLSNRFASQRLLTTIQNKLDNVFSLISVTEGYLDEWRSEISRSPGLLDASSSFERLKGQFSREVARAKNLSSLVMKRPHIPTSESVDETSTVDSSPGAAQVDYHFINSAMIDASPELQPIQHFDFVEFDRDQEQLTDSLIEARSQGISNIRNQIEQAHGIFNDIATIVAVQDGGLQQLEVNLKEAHVNSEEALVDIESLVTSRRRTSRRRLVACVNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAZ5</accession>
    <name>A0A061DAZ5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0310650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769348.1">
        <property type="nucleotide sequence ID" value="XM_012913894.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DAZ5"/>
    <dbReference type="GeneID" id="24565703"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310650"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1576"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="932"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR97162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1649" mass="180385" checksum="421E9302070CE3C3" modified="2014-09-03" version="1">MAKIRLTTLKHCFEFFEWLNNGGGPKKDVVTEFVQRLTPYFPQMSGLKGPLQKEFFKFLANVSLLYKTLSAEVTMLGTYKVTTRDRKHILEALLECTPKLLAALSFIQYHVDEAFSNVGGGGWATKSIKSGDFQTFLTNRNNILAGGFSAGELNNVQGSRLVEDLKKILNKERDGRGKGVHDHFRNVILTTLGKEWNTFNTGNTVLLVYTFCQLVTKRTELDGGAFKTALEKGLGRTICWQDLKSHCQLLKEHIDTLTGAGFSFTGRASIPKEHVKLATEAAKWFSGNLPAAANVLKDMIPHTADISTLRSFAKDHLYTHGFIFDGSKWNVWHKPPNLNKWDRILQMFRQLDGLLGKLKDILDGTYRNSCQPLVTKTEATKTEAAKPVATKTEVTKPQAKNAGGSTNQNTSQSGAKPGTSSVGTSSSPPTGSAGAPGSQGDRGKKGPGGSVSPEPAASPGKPTVKSQQTASLDSPVTSPHAPPPITPAAPASPSQPSGGGGSANGGGGAGLKVGGSSSTGHPQTPGAPSPGTASSGGSGNNGGQGLSGAGQQGDTSKGTNGGSLTSQQLAGAQVPASHQPPTAQSPGPQSTGVPGSSSDKGLGGQAGASGAAQRSVQGTHPGAGDSSAVSAIADSALGVGQSGGGAGGGVEKVKTLSPQQQLLEHYGQLLKNNAHIFKKQAERNDKAAKNMEEKIQSLNEKLHNIWQDVQEKNIRETFGQPTLPNIQTQDHSALQNASGLNSPGLSLQPNSHHPGVLPQTPQRPRWSGKGNHPATYADYDISRGYNPLNSLDGYAISDPFDVTMDGVAIPDTSFDEEEKNRQTRLQAHDERQLIKEKVDHQAYVNMQANDILKSVEEVKNSENKVLQEIKTLLEEEERQKLITTGFDGEPVVGVDYLDGEEIKHESPSKHEHERYVQLQAYDQATNIQRDKQKQWEQHYQEQNEKINNSQEEHQQEIKRTLDAINYFKEVEYRRQREAAEAVTGVPLFSKTAFNLLESPDHSTVSTLPMVTGAPIPKSNQLLPMPNGGFDTAMPPHPTIHLEIEKPHYSRIIYGFKELGNSQTPSNSIEPALPDYAIPNMDPNSDTDHSNYLGVFKNYGFTMDPNPNMCNNPWNYVYDSATSSTLPPLPYSDHLPPPTNVKAMLFWLVGLNAYGLIAKMERHMENILNEINGDTFYPKYALQVNGDLSSLSASHIADTLTEACLYSAHVLNGIMRMNSKNAWSPTDFESVYSKFHYSPDPACLLCQLRDYVYACHHQLQFLKSQCNRNKLSGGWKNDEYGSDITASKSPLQSFLTDSWDCDFKTHLFDPCNLCHKSRVRMGFKKDDLPNDSQTGNTISSILTPSCGGSDPLLTLSSYLNCLTRRTPRTTGELLSFFHNFGIELHNYDQKALSSLGTAITKSHADYPDWDHLGRHDLDAVRRIRGAESLNSISNHNHDKDHPHTLSTLVGCGSDPDSCPQHCSPITYRAYALYSQSFAHTYLSWTVYLPNRLHESLQKLYYDLQKHRGSSKCSALNLCSTALPLLYLHGITPPEVGSQVSLTCSDVICELKDVITGKPIADLMTCMDNFLYGIREPFIFTVVAMWSLAFLVFANTMLYRLDVLHIRSHLIRTKASHHIDVKALLTKGRKMLSLYKDVDYFDEDPIGQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB56</accession>
    <name>A0A061DB56_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0311150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769398.1">
        <property type="nucleotide sequence ID" value="XM_012913944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565753"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311150"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1662"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1724" mass="193255" checksum="EF33DA386974CB0E" modified="2014-09-03" version="1">MAPLFKELTDCPENLRESIDWLIQVRHGNGEGLTKLSQALKKLIEEATTNATKSLTTREKQLQCKGKGFPKAFLTDAGSAESYSGSHCDEVSEKINTLKSEIKTASESDKSKKEKDLKKLQSGLEEHIAKDHSLDESTRQTKIEEVKKQQNFVKKFGEDFNNALDGDKNLLVNLCDGLEKFLGFNPSSKGYDGHGIVYSDLDRLCDAVMGFLSGVLSAVKDDEAVKTYDNMMNNKLKDVIKTLNEKNGSGRDGIAASIAAVKGWLGGYEGELKKRTDDLKNPISSILALIDSHNNEIDKDKYFDISDQIVKWTRQAGWYISHITTCEKALEDIDNNLKEQLSSKISLLKQAANGFKQDAENEDLREIYSLARHQWNAVTSFIAESTELRSSELQEYLEKRIGGLYTRIHYLRTNEFKGLQKSANSDLQMAFETVNSGIEDLLKKYGTQFVPELQTIVKSAQELHSKIKLEKSNLQKQVSSLEQRISELKGLNEKVAGTVPKALDEFEQVNERNLWNLSNPISHLKKEVNSQLGIAIKMLWTDLQKATVTAYGKNGVANRDNPGLKILETTSLGRLPKLGPRINAAAPDPDPDGPGYHLEKLLIHIKSAEKSWESASNKITPQGKLYEEVINAILNELGDKTMDGAKNKLTELLKNTITSCIKNFHDEVTNIVDGHLSTVKPALTTIKGELERLQTKSGEGAAGGVLNGESTVEKQAYDLHETIGDFMRDKVGDITDPARGSIHKDLKGLQSNIQRLNTKVAEVRKNILAVEKELIACISDADEFLEDAPKETNNMFKRLSDAINLRIDQAFTQVQKKAENLYTARKKKELNRLKLIVKNQHHAIDKIISEDRNRSLKGFCKKLHDSLLYSTPVATDGTKTALGLTFKLKDFLSNFFDNLMTQDDLTAADSNIYRINESVKDFLAELYNKQHFHTDVTKKLDAFSNVLTNFHPETMDDAPKKVLTPLKQGFGKFVDQLDKAYVSRYSGVQILEKDYNHCAKGLLTALPILFDHFSMLNKYSGSTWRDGKINKATSLGQIFTDRGYVVSDDGKQNGELQDTEKMKGFHIHRNLDKKISEAYDNEHLRWCESNKRGKAVGFNVMDTLNCFFTHLQQYNRTCHLIHRPKAKHPASIYDMLQWLSGLSYNAVHHELALNGFTQLFKKKEEKASDVDEDGPKLVDPNADSLPAYPKRITATDLSETLLDVCHYSHDVLIGILGHGQAAGRYACDFNTNPDGLLYPKDMNGLLCMLYEILKRLQQQLHFLYEQCCYETSYSGWMDCHYGKGVGGSNWMCNSMQCPEQTGNQTHRQTCDQKCNQNAECGIKSPLQSFLEDGLQGFLPHQLNGNSGKLDCQVKNHSTVPCKTPMGFADITVMASHIKTGKHLRDILALLCGSEKSPLNALCSMLSCLLPMAPKTLGDMFAFYYNLVNGWYGKNILPREHRETAFTDAVKAANFENPQTTLDIYPMFGNNQHGYGRDSAHVRGDLYSLCSADASCYDLNSQCGPYIDSLSRTTYGTFASENADKYVSWVVYLTGTFYDLLCQLCTKCSGDCGSAKSKCRVTGCAKNSCSVFEHSVFENTKKEHGVCDSIIKCRHTHPTLYALGLTYGNRTNLDGKVGSTNVPKRTCKTFIQQLEKVCSKKSILSKLIHETIPGFLFRIRAPFIWLNVALWLLSLLYLLHIMVIRLDLLHMKSHLHSPSSHRIAAQSLLAAGRVGRLVKITYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB86</accession>
    <name>A0A061DB86_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768360.1">
        <property type="nucleotide sequence ID" value="XM_012912906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB86"/>
    <dbReference type="GeneID" id="24564715"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300790"/>
    <dbReference type="OMA" id="MGKMVIM"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="23769" checksum="A281DB39CE18FD02" modified="2014-09-03" version="1">MCDAFNDVDIKFVPLADIRPGTRRAAVKGVVVELLDDPPQSATHIRDHRYHYRFADTTASVELAVPHGILQDLVSKNFNTLSVSAGHNAELIDQVVFPSNDGGSRALRGAGQGFTVKESEGVTMNFVRGELRNIGSEFAEDSDWSGWSEDKNEESLKWLLQPGDVLGIHVSTAWSHGHMVIVPIAGKKQAILKLGRLDTNFTLEPDLSKQYTSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBC3</accession>
    <name>A0A061DBC3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770009.1">
        <property type="nucleotide sequence ID" value="XM_012914555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBC3"/>
    <dbReference type="STRING" id="5866.A0A061DBC3"/>
    <dbReference type="GeneID" id="24566364"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403110"/>
    <dbReference type="OMA" id="RIYYNLH"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="319" mass="35976" checksum="4006D0AA53B51B99" modified="2014-09-03" version="1">MAKKIGEVIAEIRALAQKNKFKEIVKILSDLAHKYEKSPKKLIAVLTMRIYYNIQLNANQSIVSDLNLIKSPYSDKWKYESYPDVNGDRKGSMCPFSLYLMYSFYPYLVGSTYTALDRLHTLWQYLEKELNEGSQPRDLTVSRIIRVRLLVADVLLGEKRYLDAVEVLMQLQQSYAKQDHATNAMLAVLYSQIGDTANAQKHIEIAMELAPPQAEIYRGMYCAVSGDFEGAYSIYNACSTSGVDMEESLLVSACENMLINNAAVSLFYLNRTAASKTTIDSCRHVCKNSRLFKGIMLNAAMLKGLAVDVDTKYAEDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBQ2</accession>
    <name>A0A061DBQ2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative rRNA methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase SPB1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0312850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48628"/>
            <dbReference type="Rhea" id="RHEA-COMP:12164"/>
            <dbReference type="Rhea" id="RHEA-COMP:12165"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90675"/>
            <dbReference type="ChEBI" id="CHEBI:90676"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769568.1">
        <property type="nucleotide sequence ID" value="XM_012914114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBQ2"/>
    <dbReference type="STRING" id="5866.A0A061DBQ2"/>
    <dbReference type="GeneID" id="24565923"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312850"/>
    <dbReference type="OMA" id="QRKDKYY"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="244"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="708"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="683"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="996"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR97382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118672" checksum="F7E6C29727A1359F" modified="2014-09-03" version="1">MSTRVKHGKERQDKYYYLAKEQGYRARSAFKILQLAKKFNIFENCNVLVDLCAAPGGWLQVAAKHLPVSSIIIGVDLVPIRPIKGVITIQSDIRTTRCRNLISQNLKGAEVDVVLHDGAPNVGANWNLDAFNQNVLVLEAAKLAAHVLKKGGIFVTKIFRSADYNSLIWMLGKCFERVKVTKPSSSRNVSAEIFAVCIGFRTLKALDPKLFNCEHVFISQGQAAEEQEEKETAKVTSLSQLLRQRKKVNREGYEEGDDFREHSVLDFLTSDNPPQMLISTNRFTFKPRSGLDEEASKKDAALLKAVMASALTTEEVKLLCSDIKVAGRADLQHLLKWRQKICRELFPADKDAKKSKAKAEKQDGEDDAVVEGDGEEGAEQPEAEEDALRRQQLELADRLRKDQRRSERKKRRALMKHKKAMAANSVMLTNDPELFSLSVLKGHDIDELDKSSDDSGDDSDKADKGKDDKASIHSRVSAAKRFDIPSDYSDTDSDDSDADSMDLQFETDSEVEDLEDDKVHNMEVDLEVQHEMAKLAESERAKPTKKLTRRQRVNMERGAELASLIESMQSEARLKAQQEMQESDSEDESEESVYEGGKSDDEGSDGSNTDDDEDDDDEEEEEEEGEGSEPESDADSEVADDKHSDDLPSTKKGASGKAAGKTIDRKAKEAMEDAMVDRWFDQDIFQEKTRETARKQKKKEPKKAKPSKKEASFAVVPAVSDADAIARVRDAVEEELTRDKETIAEVQAIGSLLVDKGSRMALIDGAYNRRTFDDGDLPSWFAEDEKKHSNYEMPVTKELMKRYKAKLYELKNRPIRKVLEARGRRKMRMERKLKSVLPRVEAMQNSDTGKSDAAKKLLRKVKRAASDKREKVYVVSRRGGSSTSAPKGGKGSRKVVKAVDKRMRKDNVRQKQKPRSQLVRSLSLCESIDLLSRARVTSSRSRLPVYTAEGESGNSGGSVVAAKDIGDNFFGETSPLPLAADSPVPAESYKPTTTRAADQDARIAALEAEVRLLKAQNAQLTVNACALYNTLMQHVEKLRATLREREAEIAEFKASSRHRGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBR5</accession>
    <name>A0A061DBR5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0302080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768490.1">
        <property type="nucleotide sequence ID" value="XM_012913036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBR5"/>
    <dbReference type="GeneID" id="24564845"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302080"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600244" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="843"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="973" mass="109278" checksum="AAE4C71B1F642D20" modified="2014-09-03" version="1">MGTYRVTRHVLIFCSINLYLMRPIVAVFCDFGDPHGLLSNNALARCYMDIDDLAPATVICPRRINDTEYVWHPQPKANENSQVKTYLTGGGMFRSVALSHVLRYESENVRVWAETTLSQSNIRLNLPKHELFAMTERRVIFICGPKDLVLSDALQRHLDHLDGFGSMQPLPWIPVTPLTEELSKIGHGLGVFYLNRGNVHLPFQGCGTRPSPLFVAHSAVTANPVTGTVSCVADPMSKSPIGFVCEGRIEPDDCMMSLLETNSKVVKAPQPYLYWKFDDYRPWVAARYFNEFALPPIKGECRCVDPVRGDIKARIVINFKTDYVCDISSKIFRDRHRSIIGPWCDVVLHPGSTLTIKVPTQPSNPISMGDDYDRDIDGDASGVPFSQLPSAYEYETEFLPNNLATLRQLKSMHDIDDYDEVWYNKTIAGDALELDVSQMSRGEVKLKYHLDKPLALRTGLNSFVYHWTLISKNQNVPDKIRATVNLSFAYSYRYVLLGCDRTQRDVFDRNMSMKHSALRSVENGIGLTYECSYRIASGAWQVGIYCSPHEELLPDNCESKGYDLYSNRVMLFPRSISNVSAYPMRGFQVFDIAFRNTPVSHACICVDQLGYEKSKLILESSRHIRYAYTVLREQAPDALAPFILLPWHEMGFSIEGLTTPRAIALYHAHYNFVTLHVGTTLFMNCESDVTPLLQVGRSAHLGVNPGTIPTKWLPEQPNLYYYNISHMHNGSEVVKTSYDETLSITPGGFQVIHNNNLYTTAYQRLTIESRRGAIIISKNPDNTKYVPMTFVCGKAPEASDLSTVTAGASTSEAPPPPDIKTIGSLTRYTWNLVEVAVEMTDPYMQGCGVTYSSTELFKPETPKLYDADGELQFGCQIDIQAAKEAAFYCPAPYALDPPNCFNHVSVDGELKNLSDISQSLVDDSSNHFVILRFDSELIGPGETLRKTPPLECRCVTTKGIVLSTIQIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBV3</accession>
    <name>A0A061DBV3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0302630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768545.1">
        <property type="nucleotide sequence ID" value="XM_012913091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBV3"/>
    <dbReference type="GeneID" id="24564900"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302630"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596192" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="819"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="949" mass="107401" checksum="90D34B646817792A" modified="2014-09-03" version="1">MGTYRVARHVLIFCSINLYLMRPIVAVFCDFGDPHGLLSNNALARCYMDIDNIASVILICPRRINDADYILHPQPTADDRSIVNTYASDYGEFRSVPLSDVIKTESGSNLVWFGSKESQTELHFNFPIHELFAITKRYLVFICGPRDLVLSDALKRHLVRINSSRFFEKFPWTPAEPLTNEIYQIGSGLGVLVLYRGQMHVPFQGCGSRPSTLFAPDEVTVDPVTGTRSCSATPMSKSPIGFVCEDQIQPENCMRFLLDKDGSVVITPEPYPYWDIKNHGPWVVARYFDDLALPPFHGECRCINSETGRLKAKIEILSETEHVCDITSKIFRNRLRPISGPWCAVVLHPGSTLTIRFPIPLVEPAFMYEDSPDVPFSQLPSAYEYETEFLPNNLATMRQLKSIHDIDDYDEVGYNETIAGDALELDVSQMSRGEVKLKYHLDKPLALRTGLNSFVYHWTLKSRNMYVSDQIRAIVEVTFAFNHEYTKLGCDRYQRQAFDQRLSRNYCATKRMGNGIGDVYECSLHLWRDAWRAGIYCRSDEKLLPANCKSKGYYLYSNNIIRFPVSVRSALPYPIRGFQVFNFDFRHDIPVSYACMCVDSRGYETAKLVLEHIHEETHTYKVRREGASNMLFSYVSFPWHKTTLLLEGTEYTYMIVLRSISKKSIKLDVGTRLSITCGLDPYDHTIASNGNVTTTWLPSMPNEFHYIVAHTSQGRKLIAKLHGDAIAATPAGFEVVDNDLPAHQELTITSHRSAILVSKDPLHKKYVPMRFVCGKTLNSSDLSIVTGNASGIPIRRITEASSRYTWNIVKVKVETTDPYMQGCGVTYESTELFKPETPKLYDADGEPQFGCKIDIQAAGEAAFYCPAPYVLDPPECFYQVSVNGEVKNLVNISQSLVASHSNHFVILRFDGELIGPVETLLQTPPLECRCVTIKGIVLSTIHIKNYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW0</accession>
    <name>A0A061DBW0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0313640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769648.1">
        <property type="nucleotide sequence ID" value="XM_012914194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBW0"/>
    <dbReference type="STRING" id="5866.A0A061DBW0"/>
    <dbReference type="GeneID" id="24566003"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313640"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="538" mass="60062" checksum="2B125AEBC6CEED3B" modified="2014-09-03" version="1">MFRKEERKKEYKKIFDDSRRRREDLQAQIRKQTRDRQFQRHRACATVEDDTTMIPEIDPVVENNVPLSFGDMHDPGDRVMSAASWSPSALAPYVTGIRSDDYETQLICTKYFRKLLSIEVDPPIEQVVNAGVVPVFIEFLGRFDAPELQFEAAWAITNVASGNQQQTKVATDNGAVPKLIALLEAPREEVREQAIWALGNIAGDSPECRDLVLGLGALKPLLFLLANSEKESVVRNATWTVSNLCRGKPKPVFQDVQEAIPYLAKLLNHTDTEVLTDACWALSYISDGNEEHIQAVLDSGACPRLVQLLDHPQSVIQTPALRTVGNIATGNDRQTQMIVDCGCIPILYKLLFSDKKTIKKEACWTLSNIAAGTRDQVEVFLQSDSVEKLLELMTCNDFDVQREASWAICNAASGGDLRQAENLASRGCLRYICSILSTSDTKLISVALRAMENILNVGHHLMELNGLPANPYAIAVEELDGVRALEVLQESKVHTVYRRARDILQQYFPEDYDLDQDLSESSMNGGFQEVVPAGGFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBY3</accession>
    <name>A0A061DBY3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0204230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767451.1">
        <property type="nucleotide sequence ID" value="XM_012911997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBY3"/>
    <dbReference type="STRING" id="5866.A0A061DBY3"/>
    <dbReference type="GeneID" id="24563806"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204230"/>
    <dbReference type="OMA" id="YMALEYR"/>
    <dbReference type="OrthoDB" id="348021at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="721"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="791"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="825" mass="91382" checksum="686957E80C584203" modified="2014-09-03" version="1">MANDGVYLFSSMQMCDAGSAFTNTNASKVSLAHTHTTKDGNIVCADCRNAAASSVPTFKDVVGAMKGLLQRGESLSAGLTLMQKFTAGREGYGSDSNIYHALERAQDAARAVGVLEGLIPTDDRPGSFELGVDSSLIASCNDLAESLIAKCQKELVAVCSSLVGHINAYCQPPLIVKFRWLRHYMALEYRVEYTADLSNCFFDAISGRYVPDVSQENVVLHEIVQCSQVSLISVETCFRLALGRMGDYLMSRKLFKAKTESAVTTPIAVDAPSYTSADVTPFWWNYYSFSNTLGEGESAVENYTVKRLTRSQILKAHEDGASTPVARKSRNSLEEHLVSTHCVSSDNLAQSCGTTFEAPTNNRKETRDLRSGEGSNYSLNCKATPTLSNRTLKNALNDESVGTVRTNKAFLCFCFKCLDAVSNFGRHFGTRDFKQENRLCSVVLGDPVKTNVLGHVYNGRQVEHWDDYKTTSVLRRSIRAAVEASCSLGRAIVSDQRHSKAAIGHSIKILNTALLSSLRLGDFIYTSRNAMEVHIGQQEDSVKEYYDSGEAMEDDGSDDSCSSESTLRDIISNSFVVGNSVFSGLYSTFENDQYIQHDLDEADEAQMHGTPTVIHRSPRRKDTSPSQRRSISNAQHSSIDSSVEVNVRQSRKNARDMANSEVYIYDLSERNDALSESAVEDWYESDGSVRGSRRQRHKQSTSSLTEIYGNDEALIPMGPLPIGVYFDASRKLWRCQWRENGKFRTKGFSLGHYSSLCEARRACILFRCQVGNMPVQPEWLNPNYVQVSQLLSKRSTTTNNNTSTPKKSKRKRKAHAGALEVDPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ1</accession>
    <name>A0A061DBZ1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0303180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768600.1">
        <property type="nucleotide sequence ID" value="XM_012913146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBZ1"/>
    <dbReference type="STRING" id="5866.A0A061DBZ1"/>
    <dbReference type="GeneID" id="24564955"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303180"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112708" checksum="749E647929EBE35D" modified="2014-09-03" version="1">MARHLPIRVTHRSSPDHRCMAISSDGNTIALAVKNEIVIFPTYSPSLPSYKLVFDTELHKLNVQLQRGACADRQQCALISEFGSPKERAIQNIRGVVHMAFHGEEDEYLIALGKSNIAIYDLMEEEANPIITAGLRRELDESAKVCFYPMNLERRTVKINLFPEKGLSCFEFMISDVKMEINYYRLVFCETDKWWYHDCGAAVNVLSNIEHRGAQTLVEPIPVKPEIKRVKIDTDDDDEEEDEEDEEDYEGEENEEEEDGADEREEEDEEEERVHQGHGDEEEEEEEEEEEEEGDEDDEDDHDDEDRQGEESEEKEEYIKELTQTTRAKRFTRSPPVVLGRENISLQNSSDGYSDGFFAEQSDAVYADNYKPLIRSADDKENFGASDDNAGDCYVQGNPNNVHRNRFDSPRGRENPKSADQHGNYGEGFENGPSSIYNQMSLTYSGSSDMDIQIDELEIRGSADQHKQDYDDEDDDEYDMDISDDTDENFYNAQKHARSSGGAADTDDNTIDEGSLSGDAYHGENESDTNMADINDAGDHSSEDVSDDMSTATPSRRIRNLADVSQGWTAVGQPDGTLESRVSLGETQTSAGNETGLGKGKVMAKHVTPAQHPAEETPFADPEVEAELRVEQSQTPVPHADPGKTIVVFSVLPASMTNANVNRKVASEYPVMEDEQLLNEALGETNSALEGRCITVNYGRVFLMIAAHEFGYVGIFRITVDYKTSTIMPEGRILQVVSGQPSATPICRIQLISPIAVENIAYSQGILGVFAVLGGDASLVMRCGLPEVTYNFGHAEVHNGEVTITASMDDAVTDLQTVFRHHETAMNALRYKVGAFGYCRGDCFFVTNSSSGLKIFGMEADARGRFLKVAIRCSKHFGFNDLVWIPHSMRVALLGRDGRMAILSPEQSTEWAKLVPNFKRIEKNAEYVEKESEFDTTLPTDEDEINRVIDYDKAHHRDRYPFFYKASYAVFGYRGPPTAGKPDFVGKPILHNKGIIDQYIERLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ2</accession>
    <name>A0A061DBZ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769693.1">
        <property type="nucleotide sequence ID" value="XM_012914239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBZ2"/>
    <dbReference type="GeneID" id="24566048"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400030"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="171" mass="19305" checksum="D40480E8F362E400" modified="2014-09-03" version="1">MYCTCHYYSYKLHNTRDSNYTQPAYMSYYTYRQSPSPSSPPTPLNLQTYQSPMQTLTNCNTTTAAPSPLNLQTYQSPSKHSPTATLPLPLPVPSSTLTLTPVSPQPWLRHPRCPGYHCCPDATHHRATSRGIGAMLAERVRYVPKCDANNRYIAAYKCYLTRPTPISPPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC71</accession>
    <name>A0A061DC71_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767556.1">
        <property type="nucleotide sequence ID" value="XM_012912102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC71"/>
    <dbReference type="STRING" id="5866.A0A061DC71"/>
    <dbReference type="GeneID" id="24563911"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205280"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="330" mass="36378" checksum="26C9EA0E1BD84FEA" modified="2014-09-03" version="1">MHNVAGFICASKRIGTSDLGHFTDGSIASKKRVFVSRDQMLTSVLYSPKAISDELEIGERCSEGFTLREHRDKSCSGVNYYKVVSKAYKVLSDPTLRAMYDANLKSSAYNRESPNCANVMTGSWLDCHADEDYVMENDSNCDTTSASSYSPENKMTVLSGRPRNIFGSNGKSFVRDYSVSEDLDIVTEVGVGLMDLIFGGTVEVSLNKFGNCQNFSCDFYVATSVCLILFMIAKIISADNENEYFEGQKVCTTAASDYADGVLGVTIDVKTFCGTKHVNVPQGTQHCDEVLVGNYEGIEHVIKIHVSLPIEPSQEEISLLSKIRDLKQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC82</accession>
    <name>A0A061DC82_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0304670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768750.1">
        <property type="nucleotide sequence ID" value="XM_012913296.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565105"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304670"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1819"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1881" mass="210562" checksum="04FD04905F6C6181" modified="2014-09-03" version="1">MAPHFKKLTDCPENLREAIDWLIQVRHGGDGKGLEQLAKALKKLIDEAVEKAKETMKHKRRKLECANDYYEHSYCTALDEKCTKAKEELKEVEFDEYYASNKGELESQIKLYEANKNDCQKDHNIGEQRKQDIQKEIDEANKVIAKLRNFSDHLEKYKDADDNILYKLCEGFETFLGYKSGNYTGQGIVYGDCDRLRDAVLMFLHGVLETARNNPNIKNVDTYNSIITHTVQSLHNARCKGDQVFKDVIPMVISGIEKYFKKVSQNNDLVTKPIEEFVNDIENIMQVYDRTKTLTLSDQYRQLKGTANACHDFAMEAADNLNNLDEQLKKRLEMPVEIIKKSAENFKNSAENGALKQECEKIDTQLTEIPKNVNIKISKNLEQLIKNHKVHVEQLEKNIVSQFEIRLKGWIDSVNAALKAAEEKGTQCINGLHSAFKGGIESLHRALKEQIDRIDMSKLSSSASEFQTAVQTLDEQFKRLNKNNNGKIPKGMVDETVENIKAVLQGFVIQANTVHHDLTNIKKPLNDWVMKNKSVGAQPTGLAGFEEKVRQGVANFVSEYPAIKKALDKTKSILNGASPDAGERLDTLLRKITEQVNALDDKVAGDLNGLKTRIYSAMKAVILDFQRGLKGLAQSSNRGSVALFIQDLRIGMRDERGDAKSLVAWTKAAESYGQFNQALEQLHRIDSDFTKLQGVLQALESFKHNSKNFFDAITQDLKDKVAESALALNNASDNIVKNHFATTMGHYRRHVGNAGQKSSETIHGAITAVSDSVLSLAGAYRGIITADGILNQVVDTLPTQMQQLTTSIASVIREVTDADSKLLETMEKANKLHTTLQDDYRKGLYNKFSALRDAVILAGRQFDQVRHRLNTVVSELNKSLALLEGLPNTVRETEETGTEALIAVFTKSVQGYKEQLRKSGEEKKESFIAETKHVLNQAHESAAGFIRQLGNKCQDAITQAFETIKGNVQSQYASSNNAQYQALVRCITEQKIKIERLIGEDLKTDLKGLLKTVSGVAANSQSISSTGNKIAELKDMNNVGDLSIKFKAYLEQIFYYVIGQLNLNSASGRVGSSDRSTQIMSPLYDSKVSGIYAIYKNVGDVMQSLGILNRFNHVILKNVHEADEAIKNFFPSKFFSTSSNPLLDVLKSGLISFVEELKNVYVSKYSGSTDTFNWEIHGNSEKCAKVCLTIFEILHCDLTKLKTICEGGSNAKQINLEMTSEDSRKVLNPLGDFFSQRGYKVPSGASTQDAELQNRSKMKGEQIIDLLYENYNIFASLHSGDDNALYDGPLVQLYNNLLDYHTVCHLRDIKNPTSPHNAFQMLCWLSGLQYNPTYHPLKEYMKTLFKKAEKHKGTEYSRIPFVDLKVEATSPLSARDTVSALRLVTVQSHDILTTLLSHGHAGGIYACNFKTNPGNLSYPSDPGACFDLLVEILLRLNHQLSFLYEQCCHTTKVSGWSDCWYGKGVGGSNWQCNDLQCTECISGKGCKTHPTCGIKSPLQSFLEDGLPGFLPHTFTKLGCKLECSVANHNGIPCITPMGFSDIGTVASHRQTGQRIKDVLRSFCGNKNSPLNQLCSYLTCLLRTPPRTLGEMFAFYYSFLRDWNDSGAHRKDGFNNAVIKANFGNSSTRFDITPMFKSTDHAANHLKGDLYSLISCSNTYIPARPCGPYMRPLCLFSRDLYSKEYSGYYLSWVVYLTETFYDLLKKLYEDCNKSCGSKGSKCYDKSCVRSCPISRDPSSSAHDPLCKSIVDCTSTLPTLCKYGFYFGSATLASGSKGDTMKRTCKEFVLQLRNVCDGNSVLAKLVNITIPQYLFTIRAPFIWLNVALWLLSLLYLIHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAARVNKLGKIFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC84</accession>
    <name>A0A061DC84_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc knuckle domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0205530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767581.1">
        <property type="nucleotide sequence ID" value="XM_012912127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC84"/>
    <dbReference type="STRING" id="5866.A0A061DC84"/>
    <dbReference type="GeneID" id="24563936"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205530"/>
    <dbReference type="OMA" id="YICSSTH"/>
    <dbReference type="OrthoDB" id="364928at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000091">
        <property type="entry name" value="Zinc finger CCHC-type-containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="200" mass="22296" checksum="74104417DCA654A8" modified="2014-09-03" version="1">MHTKYNRTYSGCWDREKIEAAIRSRQAELEGDAPKTASRIQYLKRKIAKLRRALEDGTPIGGNILPQKRSKPGNPSAAKRPCIASTARNDAILARRHKRIKKICFKCRKRGHTLQDCDEGSVGICFRCGSTDHILRDCIKPDEGSLRFASCFVCEQTGHIASQCPQNNKGIYPNGGACFFCGSVSHRKAECAERKKKVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCD8</accession>
    <name>A0A061DCD8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768840.1">
        <property type="nucleotide sequence ID" value="XM_012913386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCD8"/>
    <dbReference type="STRING" id="5866.A0A061DCD8"/>
    <dbReference type="GeneID" id="24565195"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305570"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305570"/>
    <dbReference type="OMA" id="DCAYVLC"/>
    <dbReference type="OrthoDB" id="449286at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="401" mass="45414" checksum="BAB5773D0B91244D" modified="2014-09-03" version="1">MWNAVRRCYFGALRRRYPEEVPLELLRQKAVLIENLSPGVLSTHDDVLDTFSKCGMTISQDDIHIMRNRFGVPCGRVMVLVESLLQPNFDFSESRGTPGDSAVVHEGSADTGSQAEPQHATSSTFLTKGAQKALLDSLPGESRAYICDEHDVKCYVEQCERYLTLSEDLRRFADSVNLHRIVTVTGMNKTYGRLELAEVIERHTNVKVNPVNIAFRFKSNGEQDSTAWVLCDSTRDANRIIAKLQEVAVPKRYQYGALMGASFLYAARSSLFLSDPGLDFVTKKSKYQVFTLGWQPDIDEEELTHLANSLKFFPKSVKVVRLPASDGAKDEVGAFFECDRMRNTKKLLVRLHMLKRRWKIPEHSPFYAYPKTADVRWASDNGVYAEDDPADDSDLDEPVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE4</accession>
    <name>A0A061DCE4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0206630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767691.1">
        <property type="nucleotide sequence ID" value="XM_012912237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE4"/>
    <dbReference type="STRING" id="5866.A0A061DCE4"/>
    <dbReference type="GeneID" id="24564046"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206630"/>
    <dbReference type="OMA" id="NTPAFWM"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="467" mass="52267" checksum="594D9759AFB49A40" modified="2014-09-03" version="1">MCARLDADIADQPFAVDSPVAVLRYFPSNERHISGPQGIVELYDEKGCKSRRGVASLRAFLSFRGDEFASDEAVIRREAYVEALDCNSYKVELCLRYMVEIAGVWTLSVLLPSGEHIAGSPFDINVEPSEASSYTSTLTCVPQKGYSSQQKEFIITAKDNFGNKLRTGGTPFVATCIGAAKLISLFDCKNGQHRVICDAEDTASFSQLRVTLMGKDISNSPFVLSAKPQSTASAAEPDRFLLELGKLKTQSAKSNALYKSYGRISASLVKEQREATKSYHSTRLQIVHTLPVKFTIEDPDPTLGDKRKELIARHNQLTAEIEELSAKVRAAETVRKEVLDSLVERYDRSTKLHKEAVDAYKVVRREIGELTSSTKENRRLADALRSGDMEAVRKVQEMRTMEDTVAAYYRGTEKAENTRQRVQLVSRQYMSNEISSHMISTTPDRPNTPAFWMMEGRFKPSNKIQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL1</accession>
    <name>A0A061DCL1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0207890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767821.1">
        <property type="nucleotide sequence ID" value="XM_012912367.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCL1"/>
    <dbReference type="GeneID" id="24564176"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207890"/>
    <dbReference type="OMA" id="FLESWSM"/>
    <dbReference type="OrthoDB" id="361329at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1488"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2223"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2285"/>
            <end position="2307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3146"/>
            <end position="3247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3754"/>
            <end position="3780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4810"/>
            <end position="4829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4871"/>
            <end position="4891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1494"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3159"/>
            <end position="3170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3178"/>
            <end position="3188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3198"/>
            <end position="3207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3754"/>
            <end position="3768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="4961" mass="551737" checksum="49D1BE780D9BFBEE" modified="2014-09-03" version="1">[encoded data, 4961 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCL5</accession>
    <name>A0A061DCL5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine cleavage T-protein (Aminomethyl transferase) domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0207940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767826.1">
        <property type="nucleotide sequence ID" value="XM_012912372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCL5"/>
    <dbReference type="STRING" id="5866.A0A061DCL5"/>
    <dbReference type="GeneID" id="24564181"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207940"/>
    <dbReference type="OMA" id="IGFETYD"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="216"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="457"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="734" mass="81722" checksum="CC6BB70ABDD27F28" modified="2014-09-03" version="1">MRQIIRRRRQANTAKHDEDGSLYALAEAYLDAEHEMLAAAPSQDAVLRHKISQVLQQRFNYNPIQPFTMNHGPDSNIAVEPQEGSTSPKSRKLHTNKVTDEGNGDCSDLPGDNNEHNATTSGNASEDGTEHRDTEKITHPNDPKHTITDLKNMALRNGTILKIDLSSVTAADANQGMEDVFDALGSLRLNQEMLRLWTDQKAMDVVYFNDSILPILSTSAEEEYFHIRNKAALINKSYALPIMVTGKDASDFMEHFATCSLRSMKRGMVQYTALVDTKGSVMDMAYVAAYENSYLLVTNGLQKRNLFDYMSAYQMSCKRSGMDVALRPLLSSVLISFQGPSSVDILQAIAKNDSENATQQTDEDVFEQQGQSNYAETQDGCTIKVPSTLPPFMRCFECELTLPCTDKAAPMPNKTYPIHCLRVSDVGEDGFEMLVSSDVAVPLLSAVILNITGITDRRVGLIANERVDTNCNILNGDTRKPIGFVTSCSWSYGLKMYLAQAYVNAEYARHDMPVLLSLPLKPEAPVTKREFRKYYRNKTRRTIIRGTVVRLPFVLHNYPISASEKHYVGGRHVPLQTLKKQPASKANGEARPMPGHTSDRSPPSYDTALVAENRVGTTGSSDSPAALTETSQQPARLKTRKQLWKEVVNKQRSKNAKTLEMALTQVEKATVGACVDQPLDGETCTEQMPLPTQRINITPRAAVPLEKTVEYYRELHSKPVPARHRRYRPPMAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR8</accession>
    <name>A0A061DCR8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770148.1">
        <property type="nucleotide sequence ID" value="XM_012914694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR8"/>
    <dbReference type="GeneID" id="24566503"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404500"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="79" mass="8768" checksum="8C4F0F7C45D53AE0" modified="2014-09-03" version="1">MADLLGAPPEVLEGKRVHSHHTHAEQVAHLNHLYIMMRKVAFAHLKKLSQPVMVTLLYIHPELAGVAAVTVHDESSMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCT4</accession>
    <name>A0A061DCT4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SYNTAXIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0307780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769060.1">
        <property type="nucleotide sequence ID" value="XM_012913606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCT4"/>
    <dbReference type="STRING" id="5866.A0A061DCT4"/>
    <dbReference type="GeneID" id="24565415"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307780"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="195"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="287" mass="32704" checksum="23C673755DC87E5F" modified="2014-09-03" version="1">MVSGVNRTNVFLQEVARNSPVAASSASPSAEPSQLEVDAQRLSVELSKCGMKLSELTALARKRSIYVDHTAEIERLTGEVKESITAASNRIDAFESRMNSVRHKNEHMRQHYENLLGSLRKELCELTKSLKDALYQRAQIMIQQESRRKMYSHSDLDRNAMSSGYGRRRFTMQQPDEGGQQFDIESGELERPSRSVIADAKAEALANVQRAISELTQIFQRVTTMVTQQDEMIQRIDADTEESLNNVISAQNELSRYYKRISSNRTLLLKIFFILVAFVIIYIVFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCV8</accession>
    <name>A0A061DCV8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0308230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769105.1">
        <property type="nucleotide sequence ID" value="XM_012913651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCV8"/>
    <dbReference type="STRING" id="5866.A0A061DCV8"/>
    <dbReference type="GeneID" id="24565460"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308230"/>
    <dbReference type="OMA" id="FCYINNE"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052842">
        <property type="entry name" value="ER_Co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184">
        <property type="entry name" value="DNAJ PROTEIN ERDJ3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184:SF1">
        <property type="entry name" value="DNAJ PROTEIN ERDJ3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45801" checksum="B39D63254FDD222D" modified="2014-09-03" version="1">MESRSQWTAALVALTAAAVATIGCSSLLIDPMQHELQVGNETTFVSKVKVARQTTSTAAFFYTPSDSGIKSLIDKEVDVVSRELKGIYTIVAMDCSSPSLKSICEAELGAGYSTPVLRVYPKLPMPAYNYSGNMVSAMIKRELVKHVASLVEVIKPGKLPEFMGKFETMPKALLFSDKAGPNYVYKALSLVMDKKLLLGFVNVGENPELKARYKVKSLPDLIVVKPDSKVDRFEGTFDYSSMFEWLNVYSETFLLGSGYDAGNTKATKSKTWKHDPLPQLTLESHMDICFNKSHGFCVIYLTNGELGADDRQMLMELSARYKGEFTGKWMWMNLAAEPGFAELFGQPAELPSVAIFNPKKKLRFMIFEGDGAVTREGIENMLEKILGGDARFKLVRGDKLPAFAPVVASQHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCX0</accession>
    <name>A0A061DCX0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770243.1">
        <property type="nucleotide sequence ID" value="XM_012914789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCX0"/>
    <dbReference type="GeneID" id="24566598"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405410"/>
    <dbReference type="OrthoDB" id="366351at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="160" mass="18535" checksum="77A88A53547A2563" modified="2014-09-03" version="1">MALCARKNGGANASRVHKDKRKCLDDFMPAQTHRSDEITYRLPAYTYTQKLEDYAHFKDPGRIATAMWRDYVDNSGQSGAKLNRPLRHYPAHHYRREIGQKIGLQRKEARLRNVLRASTMASAKNDVKALNYTHQPVVLDALKHYEVWRNLSLARQTSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY2</accession>
    <name>A0A061DCY2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0405620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770263.1">
        <property type="nucleotide sequence ID" value="XM_012914809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCY2"/>
    <dbReference type="GeneID" id="24566618"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405620"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR98077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60130" checksum="883AB3EA75487329" modified="2014-09-03" version="1">MSEPQLSPPKSSSEVELEAAKQDATKQTEDYGAFGQVLYHLVSFTEGYEQQVLYLCMRLFESTMGFSKQQQTMLMTVSIMSRLCFSLVWGLLADAFETNLVMSAGLLFMGIASILLSTTSRFSSQKIISDKDEDDDRNSSSSAFTRLHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYVWISIGIAIIFVMTTPKELISPYNSMMGVVQQISGAFKAVFTNWSAFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDLKVGIAIVVTTIGGAAGTAAGGIVIEKITSMHKDYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIEDKYQASASAIIQCISGISISVSFVEIFAYVSEKLHGYAPSKQAIDDMDAALKDNNTEALRKSTMYMIVIGSLLNIACYGALFATYKEDKKTVEQKNVVEWKEREVRQEMKSLKTLAEQPILKLPDEPAAKPEATEVAIDPLELPIEERRTSYSDDELLSSTEDILQLMRTGDAEKRSWQYPGTDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD33</accession>
    <name>A0A061DD33_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768096.1">
        <property type="nucleotide sequence ID" value="XM_012912642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD33"/>
    <dbReference type="STRING" id="5866.A0A061DD33"/>
    <dbReference type="GeneID" id="24564451"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210620"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210620"/>
    <dbReference type="OMA" id="ICVICEG"/>
    <dbReference type="OrthoDB" id="360619at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18570" checksum="4F40A58955DAE79E" modified="2014-09-03" version="1">MTDHEDSSSNDEGGAETGVVDNAATTGARKDDVIPTLLLDVVERLTKIAVMCESPNTADPSSVKNLVKNMYKFEKALRKLQKVSQQEHDGTDTIFKGALRAVDNYVNPYDWAMTNVVNKYRTAGMKLDTALDAVDMLHKKLVERLQNNPAQNDAKDVASETAGDVVNEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDB9</accession>
    <name>A0A061DDB9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0300450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768326.1">
        <property type="nucleotide sequence ID" value="XM_012912872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDB9"/>
    <dbReference type="GeneID" id="24564681"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300450"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="105" mass="12054" checksum="63F2F7F52C9310A8" modified="2014-09-03" version="1">MPLTGEIFKIGHVLSEFYQNRWPPYVLEPPNCFDQVYVEDEVKNLSDISQSLVASHSNHFVTVRLYSSLAGPYETLRQTPPLECRCVTIKGIVLSTIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDI2</accession>
    <name>A0A061DDI2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0313310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769615.1">
        <property type="nucleotide sequence ID" value="XM_012914161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDI2"/>
    <dbReference type="STRING" id="5866.A0A061DDI2"/>
    <dbReference type="GeneID" id="24565970"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313310"/>
    <dbReference type="OMA" id="WEFYRWF"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="703" mass="79268" checksum="1039CCC495F828E8" modified="2014-09-03" version="1">MHGIRREDVYKTPEEEKAFANKLEKGFKLLDSFVASVRESDSTVSPSCGVLEDADEADRMFALSTAIIDFMPEFYPSWHYRKNYFLQPRLGEERLRALLADELSFSESVLKTSPKCYAVWQQRLWVLTLMFNMRCEDVGDILRKELSLCMMLFRLDGRNFHGWGHLNYVRHYLKLLESDSANVPPLPVDKLCYTEFSKLIEKNFSNYSAWFHRGMLSENCGCVSDDLDNLTPAIYTDPNDQCLWHHFDWLLYRRNALRYYLVRCCYFEESQSFVFFFNECVSLSTTDSFISVTSPDGNHAKLDGSWSAVSSSPRQSRLSSISVPEYAWRFTLTAPLSTNPSTCISPSLMVETDERTVESFYSHLRHLPKCNRTSDTRDVPNPPPCLLCLRYKLHLSESGELPIDLDSLEFMRSNMASCSGWEDLSGVLRAPVLLPGSSRIVSLGKDITPAILEQQLEMIDTLVGMGTESKYLHLARHKIRRHLGQPSDADECYQHVTRIDDIRARLHSDMLLVAKVQSALDASAAAGSTSASLSGMGIRRLPYRALSPHFTLEELDLSDNSLCEGSLIDIGICLLLRLHTISLARNGLKRLSSTLEVLRNLSRLRRLDLSGNPLDSMDQCTPIFVPESLMEIDISDTPLAAFLLDDTEQHGAATVVPRKYPILDGFEVHFDEPGSATSHRVPSSVSGAAPVAAVLKRASGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDW7</accession>
    <name>A0A061DDW7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768826.1">
        <property type="nucleotide sequence ID" value="XM_012913372.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565181"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305430"/>
    <dbReference type="OrthoDB" id="366456at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1653"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1715" mass="191688" checksum="F37B010839BB0E36" modified="2014-09-03" version="1">MAPKKLTDCPENLREAIDWLIQVRHGGDGNGLKHLAKALQKLIEGAIRDAYNSIVDKYAKSLEPSWKTKECCKVKFSAIDEIQKLLKQPNSLENAPLNDHLKQLTYDKESCEKNHYVESSKDTALKDVDSKLSELKKLQRNLGGLIEDPETILTQLCAGLETFLGFNSATKGYDGSGIVYSDLDRLCDGVMGFLSGVLEAVKDDPSVTTYYKDMGATLRIIKESMYTPNGLSEAIKAVSQALREWDEELGIRAKNVSDALKTLITHRCDAFSGALQNLKAIAYDDQFKHIGAKLSNCIGTAGEMSKAFDAAKLAYSNLDPELRRKLQGAIGRAEVQVRAFIVAASNDELKAVVECSEYQLKELGDEIHTKAELLVGQMSTNINTHFEANIKKPLNDVNEKLSMVHRDLVKWVEAAEKFIKIIEQQVTAIINEVELVKGKPHEISSAAKAIEAQATKLHTQFEQLKKKYDEVITTIKGNKGDGEEKECVIRLLDDVHSKVNEPSDIAQYKQKGGDWGLQNNIEPLVAKIKKNVEDGVGTLVTALEQAVIVATNDNPINGEYPGLKVMQVNALGKIREVGASLGTAIPDPTPTGPGAKLEKVLNHLNSAKVLWTQITQNITRQIFEGVKNELATRANAVDTELGALLQAAAISGATNLHNEVKRIVNDKLKNIKNEASELLKTAKSAESIIIERAGVVENNLKQLCKKIEELAGNGLEDRGLKQKLLSMKSIVMDTLHGEVSYSLNGILTRIKGIINSNTEGNLQAIVSHVEAFKTAIIDKEVQDVNSNIQALVANKVCEATKEIQKKAKDEYHTKISTMFNTMKTKVEYNILEINDIIEDDSESGVKGLLRKLYDKQGGRLASLKHPKERQIKFAFAEMSKKIQDYLDRILLYTEDQVMTPPPPKLRVQKTPTEQSEQVKIIKGNLDILLDVLQKSNHFDHQFSYNYQKLDTTLSALHPKKFTTRDSPELLDTLSKGMSGLTRELQKVYISTYSGSFKYFVWNGEVGNKCAKIGLTLISILYDGLSRLRKECDSKSGSKWNHKPINLGKDNGLGAFLDRRGFIVSSGTDDQNGELRNEKGCRGDLISDVLLKHNLVSEYDDNETNKESCSTLKMCVDYLHEYYQVRHLSSLGSLKHPSTIYEMLCWLSGLPHNLTYKYLKTYVKNIFQVSDKRHPFIGAYPHPLSSKNILDLLKHSCSESHAIIVAILGNGHVGGIYACDFYTNESGLLYPTDMNSLICMLHDILNRLYFQLYFLYQQCEYDTSLSGWLDCEYGRGVGGSGWRCNVDQCANQACNQKGEQRANQNDYQKADQRCQEYPKCGVKSPLQSFLEDGLQGFLPHHLKSERGKLECSLKSHSGLPCITPMGFSGISQMASHRDTGQRILDALGGYCGHQSSPLTKLCSRLNCLLPSVPKTLGDLFAFYHQFLINWSGEHKKTAFNDCVTSANLGREYGAMNECAMLFESTDHSTSHNLGDFNSLLTVDNACYVSNGKCGAYLDSLSYEICGTFSKRNAALYLSWMVYLTETLYDLFYKLLKECENNCGSGESKCRITGCDKNYCFAFKPQIGQEIGQMHTQLCNSMLSCSMTFPTLYSFGLVFGGRRQLSGRNHNNYIIKRSCKDLVQQLQIVLNERSILSKILHDTIPNFLWTIRQPFSYLIITWWSLSLLYLFYVLLVRLDLLHIKSHLHSPSSHRIAAQSLLAAARVGRLAKIFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDY1</accession>
    <name>A0A061DDY1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768866.1">
        <property type="nucleotide sequence ID" value="XM_012913412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDY1"/>
    <dbReference type="GeneID" id="24565221"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305840"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="66" mass="7582" checksum="2297AB19D8ED3773" modified="2014-09-03" version="1">MQCHHPGPHLRTCKALEIVPAVIICLLSVVLLHISRDSVLTKEVHVRFAKKYLLSRHLITAFRCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE57</accession>
    <name>A0A061DE57_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">-Transcription factor TFIIIB component B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770185.1">
        <property type="nucleotide sequence ID" value="XM_012914731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE57"/>
    <dbReference type="STRING" id="5866.A0A061DE57"/>
    <dbReference type="GeneID" id="24566540"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404840"/>
    <dbReference type="OMA" id="VENDQPC"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="244" mass="27329" checksum="71453BECEC541109" modified="2014-09-03" version="1">MDRSGKSGLALAGALLPGGVEDGSSVDFGHETVWQRVQRLGRNQDPFERPVAAEPTQSASNVDLSFFGADVQALLGARHHVAETAFNKRGQYASAYKQTKRLKWSPEDTERFYDAVRNFGSDLLMVRSLLPEFTDKQIYDKFKLEEKRNGDKLNEALNTPTKISLEQFERRNGKIDRSRHYDPSKDPVLLQKRSQKTNQLALRVQVEDDEPRALPDSSEGAPGPVHDLDADTDAPGCNIVELFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEF4</accession>
    <name>A0A061DEF4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769371.1">
        <property type="nucleotide sequence ID" value="XM_012913917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEF4"/>
    <dbReference type="STRING" id="5866.A0A061DEF4"/>
    <dbReference type="GeneID" id="24565726"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310880"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="435" mass="48504" checksum="278E14742C5AE189" modified="2014-09-03" version="1">MPRNTFVVPLVELNGDAPAFVNEVEGIILANSSKSDANVPISQKINYPVPQSMFGGSPVPDAELPSSPIPRDTFLTEPQPTREFQIEFPKRTVRKIEPEIGLSIEVPPHEDRTFNDVDLDDPYANTADIIKDELRPAEDKGFSGLPNTNFDLDFGPERIGLEGYDDPGMPRDSPRKADERVINPFSTNECQNPWSVDTSSTDTPPPPATDHLPPPKTVREMLYWFVGLNTYGFIGMITEYVECLLKNANKNAFDMQDALEVTGGPITLTASMVTTKLTEACLYSAVVIYKITHNNDFEAFATFGFESVYSKFRYSPDPACLLCQLRDYAYACCHQLAFLKAQCNRDKLSGGWQDCKYGSDIKTPSPLQAFLTDDWDSTFKTHPFDPCNLCLKSRVRMGFKKEDLPKESQLGSTLSTILTPSCGGEEYDALHGTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEF7</accession>
    <name>A0A061DEF7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBIQUITIN-CONJUGATING ENZYME E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0311030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769386.1">
        <property type="nucleotide sequence ID" value="XM_012913932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEF7"/>
    <dbReference type="STRING" id="5866.A0A061DEF7"/>
    <dbReference type="GeneID" id="24565741"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311030"/>
    <dbReference type="OMA" id="GPESCSY"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="139" mass="15961" checksum="9BF826FAAA12454F" modified="2014-09-03" version="1">MDEIKVPRSFKLLDELERGQKGSVSEWVSFGLERPDDITLSNWSCTILGYPGTVFENRIYCLEVYCGEQYPDVPPVVKFLTRINLPGVDQFGNVMANYFPGLKNWKRTSSIEAVLVDIRRHMAMPANRRLPQPEEGDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEG5</accession>
    <name>A0A061DEG5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769426.1">
        <property type="nucleotide sequence ID" value="XM_012913972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEG5"/>
    <dbReference type="GeneID" id="24565781"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311430"/>
    <dbReference type="OMA" id="GKKNKCY"/>
    <dbReference type="OrthoDB" id="364221at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="403" mass="45153" checksum="C9CC990499E30CEF" modified="2014-09-03" version="1">MVAVKSSDDLPSAVEDDADYEVAKNQIVTEVKEVESLFKAVLSRIFSHLYHYVKHKAMQSYLSFYIVSPLGLGIGNLLNSNLNDQYITNKLGLPENATPATFNIAYEQVEVPSHFSKAHKQCWLIRSTNPKATKAFVLLHGWFGNMQSCLQFADMLSKMGSLDTHHILILDLHDDSGKSFETNVGLKGVADIYDAAAYLNRELGVDHMSLYAQSVSCISALLFNELVSRIKKPLEDTTREAICPLFDGMDPAVLRNFTVDTIIMESPVANIRNHVANSTTESVNWFMEHVLSLVNKGGFHIDNLSLRTLLRDPETCSKSYIMQGAKDTVTTPQMLRSELMRSDLPSRINMFLFQDGGHANLSATSKPDYYYTIKHVTVGRNAWEFLTRKGTKTRVDDPDGLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEI8</accession>
    <name>A0A061DEI8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769541.1">
        <property type="nucleotide sequence ID" value="XM_012914087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565896"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312580"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1651"/>
            <end position="1671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1713" mass="192488" checksum="69212723935E99DD" modified="2014-09-03" version="1">MAPQFKKLTDCPENLRESIDWLIQVKSGGGLDDLCNALKILIRDAIESAKASLKGTDEDGFTSCKKCSKKISPKLLDPADSCVCPEHKQVEDLEKQLKEFIGQQEGDYNINEILENLCTCLETFLGFNSESKGYDGEGIVYSDLDRLCDAVMAFLYGVLSNIQSHLGQHNGQITDAITLLKQNKHLGKNGFNDAIEKVVAGVRGYNEKVKRSNGNVRSITSKLLQYVTHGGDFNRDFNGIRVDDVAGSPEVKDAQVTKVEKLVKECRQNAREFGKNIRRADKDVADLNPQLRQNIERVKINIAHESKKLEDIHAKQQRGLEATEKIIKETLHGLNCNVNEKIKIDVEKLVADLKEKISVILKNLESINEKLKECINDLTDWITKADSVVEESYKLVQEILNALKDDNSNTNPYKIQDVAEKLKVEAGVLHGQFDMAKSEYEKLFNLIKGKDGDGEDEDCVIKKLNEVHMNVEKLVPERDLISFNTLDGDWGLKNQINPLIQKIKDNVKEYLESLRAALKEGIAVIGRQYGSGGAVIPGSNPAVEALVSKMGQSTELKPLGGRLETVRDDKSGQGFALEKALKHLHDAKEELTPSTNLLEHMYENLKSSLQDKAVAVDSELCNLIYGACINGISELQEAVTAIVNEKLEPLKDEVSKFIKQAEESKQGVIDYAQNVTKHLRALSDDIMKALTTDDEKEVNDRLRGRLNDLKQKISKDKPNITDSLQDLQRRLDKLHGDVKAGPITKLKHLLNTYADHVRDKYVKQTQEQVNQQVKRAVYTITQQARKQYVSFVSDMLTLFSTKVAEELTGLPQEMDHELVIGFHGFMHRFEYTFNPNFSGYAANPPETLHDLSSKFSHSINYFVQELKTQTNLDADVARLSSPFSAVSRLFNDLNTSHHFDHTFSQNISDLISKLEHCAPKQFGDPSNAMLDVLKFGLHGLARELSKAYVSVYDGAHPINQWVDEKRVLTTEGKHGAKVCITILEMLFKDLNDLRNKCKEGSECKYKTICARNGTVENPLGAFLGRCGYIVSEEDKQNGELRYKNDFTGQHIRKDLLTKIHGIGDAQYKLVSDDDEKEEIKVDGEERVITANPPDHGVLRTLLGYLHDYYRVCHYASSGSKKSPRNIYDMLIWLSGLPHNPVYHELTFSSFDELFDKSEEKNVNVDGTVLSLAYIDDVSFVAYPETMKVSQLTSALGDVCSKSHSVLTAIVGHGHSDGVYACDYNTNESKLQYPSSASACFDMLVDILYRVYHQLNFLYNQCCDTTDVSGWRNCWYGNAIGGSSWKCNKLQCPDQLGNPTCNPTCRQHPNCGIKSPLQSFLEDGLPGFLPHQFEKPGCKLECTVSNHRGLPCKTPMGFSDIATTASHRQSGRYLCTVLADFCGGKDSCLTEICSSLICLLNRPPQTLDEMFAFYYHLLNEWNSKSGAHEAAKKHKKYAFEVAVKKASFGFYDHLDNTTIFKSINHEAHTKGDLFSLVCSNMADVKCGKYIKPLSHNIWTVFSQKHASRYLSWVVYLTETFHNLLDRLLNECIATCGEGNKCYVKCCAATCPVKSAYASKTPIIGLIDKHHTQDCKSITHCPSTRPTLSKYGLVFRSPYDLSGINNVESKRTCRDFCYALETVLNKEVHLERALAKFVFETIPEFLFRIREPFIWTVVALWSMSLLYLFYVSIGRLDTLHIRSHLRSLSSHKIAAQSLLAAARVGKLSKISYLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN2</accession>
    <name>A0A061DEN2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769761.1">
        <property type="nucleotide sequence ID" value="XM_012914307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEN2"/>
    <dbReference type="GeneID" id="24566116"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400670"/>
    <dbReference type="OMA" id="YAAYNLD"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29212" checksum="67B44A45A3BE3FCB" modified="2014-09-03" version="1">MDNFGFGVLGGIFASGGGGEEEVDNRPKVLQRTDSFADYTPPEITNFQPSTLQKKLKQDSGAVESIMPVKISQILANLSEGNQKFSLYNQAIGAICIVGQIQDLEKLTSAVYFQLTDETGSIAVNYTDEGFAVQQGDYVQVVGSLVLLASDNFYVDAQNVMLIGNDIDHYPDLLMHHNVLVAYTAFNLDLGSKLKLQNKHTGKISELPGQSTGRVSIADIESVALGELYDHITEPVERLILQYLKARPDTLAKRSDIMACLSERYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEQ2</accession>
    <name>A0A061DEQ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA binding motif containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0401670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769861.1">
        <property type="nucleotide sequence ID" value="XM_012914407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEQ2"/>
    <dbReference type="GeneID" id="24566216"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401670"/>
    <dbReference type="OMA" id="NQMRYNN"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="166"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="294" mass="32418" checksum="84D05EBD0B820FB3" modified="2014-09-03" version="1">MANTYNYALGKDVKIFIGGIPAAITEEKLRWELSKFGGLTSTFYMPDLNQGSSGWAFATYTDRDDGAAAVEAIDGKLYFEGLEEPCKAQVVTTRNPPDSLKATCSTHSGPVMAAGYWQQFTNADGIPYYYNMRTGQTQWRRPLEMEHQVPVARPVVGNTLFGPPGSNLFVFHLPAEWDDADFVLNFQQFGTVLSARVQRDSAGRNKGFGFISYDNPLSALNAIKSMNGFNVAGKYLKVQLKKGEEHCVYPNTGGGPSICGGRSESIRSNTSAGKQYRRQLQRDNRGKAEHTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEW4</accession>
    <name>A0A061DEW4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770171.1">
        <property type="nucleotide sequence ID" value="XM_012914717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEW4"/>
    <dbReference type="GeneID" id="24566526"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404710"/>
    <dbReference type="OrthoDB" id="366422at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="142" mass="15841" checksum="67AC9B98E3CA5C4A" modified="2014-09-03" version="1">MAVRESALTDPQVAAMYDHVSSGGELYCKRDLECLMRQFDIKPSQHRGKVPIANGHTAAEVVSQLLEEGLLCTQRFKNVIVFWASVPSSRVGGKKVEAPVRSEECDLANLQLRYCTLKEELAKLEATKGASERLASNNRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEX3</accession>
    <name>A0A061DEX3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770216.1">
        <property type="nucleotide sequence ID" value="XM_012914762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEX3"/>
    <dbReference type="STRING" id="5866.A0A061DEX3"/>
    <dbReference type="GeneID" id="24566571"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405150"/>
    <dbReference type="OMA" id="IRAVFMH"/>
    <dbReference type="OrthoDB" id="191535at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40861">
        <property type="entry name" value="DUF2183 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40861:SF1">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42175" checksum="98D4F1691764D72E" modified="2014-09-03" version="1">MSAAQHGANAAAPELEGAARRLSSLDISNTARSQLLPPSGGEKTPKPADSNTPRASAPSTPSTAFGMASSNVEKMQKAAAQRVIDVNDPSLEWGPTQVIIDIDDTVKSSGGYKLFNVPLGGVDTQYGRGELYPGSFQFILELAMYKMGKNRKPLLLAVLTTRIPQVPITVDSALNMRLREVAEKRGVLNWGIDCDNKILYSTIKEWVFNETRGEKKFVNFRKLHKYVCNENNNARFIWIGDTGDRDLEAGELMIKSFPGKIRAVFMHCVTPDEGNEGQRMPNDYYLKSVPVLFFRTYVGAAKKAVEHGLLNHNALSRVLVRAVLDLNENSPQDLSKWKDLIRDILEVEEIANLKRYEANLVVKTRVIIENKIKELAHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYD5</accession>
    <name>A0A061CYD5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FabD/lysophospholipase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0100050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765862.1">
        <property type="nucleotide sequence ID" value="XM_012910408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYD5"/>
    <dbReference type="STRING" id="5866.A0A061CYD5"/>
    <dbReference type="GeneID" id="24562217"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100050"/>
    <dbReference type="OMA" id="RNDICEY"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF7">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="289"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="322"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="853" mass="96670" checksum="20A7E2F1FF395E3A" modified="2014-09-03" version="1">MSFSSSNAMGFHSDFWDHHSQLTKPVASSLASLKGIGFFNDNVCKPDLPNNGKVDEFKGPRIYMGALNIRNDICEYIKYFNVAQLKQYMADKGVDTDHITCADVVNDYKLIENLAHVQQLVALTQKYEDPDPTAFVAKVPRKNEKDIEEAGTKAASYLTYSSDFKIKYVPPPLAKKCPSTAYPSFTLMFAAAVDAVHKFALSDAEESKEAVSYVKRACLHLQLFTGGAISGAQLIYDLLQDYATMGYVLIDDKSDGKPPATIREAIEMAKFVIRGEMQQRTIYKPDLAISLSPGGFLLPMFVGFVDYLMELNIMNMTVPISGSSAGSITSVVTSVYNRNRYEIMELFEEPAEAFMSNTPRGTLDEVFTPMVSAFVPKELYKTLNERIGRVQVNYGVRKDGEFEPRCVTSYESNEALINAVRASSNVPSFFKMGAVVINGEEAYDGLFAANNFFVGATKSPGRRTVRFSPMPLGIGRFIGTSLMNGVANSFLQKKDMFYIHFIRLKSLIRQLLTRRMEYLRLDKTEQWRAEIEQSIKVYNAIATSKRSRGIPTGEVEKWMKMLSTKPGETQSEGAQQDCALTKLFRLVVASERALKIGTGSKRHAGGYKEKLGSGNILRTFTDPTKSDYNGVEFLSTPHTLIEWLSYELVYVSDEELSKNPAEEEINTLKDILHHLTPPASFTYHFTDFPFIILSGLSTLENMVPSFYPAETHTGRHLFDTGRAMGLRWLLAEYIAFENWLYLRIRQLTEEPELATLEWQKVTPRATQEAHAHNVEPLHIRQYDRLNSTVNLMRKERVYELLQLFEEQAPVTDAKRLLFRLQNRLMRRALAYGIVNPHFLHILGHRHFWINEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYF7</accession>
    <name>A0A061CYF7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765877.1">
        <property type="nucleotide sequence ID" value="XM_012910423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYF7"/>
    <dbReference type="GeneID" id="24562232"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100200"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="172" mass="18493" checksum="C25EEDBFCD32F4DC" modified="2014-09-03" version="1">MGGGQCSGLRLRGLGAAGEDVDVYLWYWMSNGLLVHKASPWTYKCSDSICGKRCKGKEYACQCTCCKDKQRRGLAHPPPPPPPPPGPSSGVESVIIGQPQTSALSTEPNPVDISDAGDSTPFSPSPQVIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ79</accession>
    <name>A0A061CZ79_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766117.1">
        <property type="nucleotide sequence ID" value="XM_012910663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ79"/>
    <dbReference type="GeneID" id="24562472"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102590"/>
    <dbReference type="OrthoDB" id="360565at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="17280" checksum="C6224E838485D14B" modified="2014-09-03" version="1">MLLLWGNTTDFSQSRTVYWSIQAELSIHKSQPSALLQVYWQSSRFHVAAVDVYSLTVTTGTALSRPGTRPGCMTAKEGATAQPTVHQEGVCAQLKQVYERCFDAWLKNDLLKGVMEDKCREQLLEYRACLKEHFASMGEKEIVSAIEQYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ84</accession>
    <name>A0A061CZ84_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium-dependent protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0102640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766122.1">
        <property type="nucleotide sequence ID" value="XM_012910668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ84"/>
    <dbReference type="STRING" id="5866.A0A061CZ84"/>
    <dbReference type="GeneID" id="24562477"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102640"/>
    <dbReference type="OMA" id="DHPNIAF"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="156"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR93936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="593" mass="66640" checksum="E3A6CF0CA816AFFD" modified="2014-09-03" version="1">MGNCCLRKSVCANRRVTSPQLHGDFHGRPTQQSAEDMEALLYIAPDICDVFFRGLRRPVCVPNSARDRKDGTKSGMPTASTGIDMEYQPSATEQHTNDLHQGQPGGDSIAPAPPESGAADLMRNPAEYPRIADFVLSRDLWRSRVLNRYKVTARYHVTPTAIGYGVGGSVREVFDRTSKHTYAMKTLRTFMPSRSAIVSAINEIAIYAQLDHPNIAFLHEAYEDVGVCHLIMEHCTGGELYDRLDSYKRFAEGYTKRLTVQMLLAINYLHVNGICHRDLKLENWVFGSSDLGAQLKMVDFGFSRLFQRGVPMGGTHGTVYYVDPEVIDGCYNEKCDVWSTGVIVYMLLSGSPPFNGDGDKEILWKIKRGPLKFEGARWSQVSDQAKEFITYLLNRNGTERASAYEALNHPWLSEEVQKFDDSIVTPEVMRHIAEFSKKSPLHRALVALCVLEADRNASNEIYRVFFAINTSRSGAITLKEFTDAMRKHLDMDENEAAAVFDTIAFRGTPTMQYTEFVAAVYEYYTEVDMELLAQVYYKLEALGNGRIDVNAFVACMGERFNGTLVASIFEDTDVERKGVIDFAQLQNCLVSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D054</accession>
    <name>A0A061D054_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766402.1">
        <property type="nucleotide sequence ID" value="XM_012910948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D054"/>
    <dbReference type="STRING" id="5866.A0A061D054"/>
    <dbReference type="GeneID" id="24562757"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105250"/>
    <dbReference type="OMA" id="QIVEVCM"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26639" checksum="B71809E3B03566AF" modified="2014-09-03" version="1">MRRGIGASRILNSQKEQWDSFSQTLSEETTEAFKRVADDFKADMCHFVEKYKNVINADPYFRLEFLEMCDLVDFDPLIHSYSSLSRILGLSSFYSMVTMRMLEICIQTRGLNGGLCEIRQVLDAFPKKAQIRADDILISIRECAAFGKNSIRTVRINDKTIIVTTPIVLGDDYSECLHLAAGLKRGVAVSDLIDGLGWNHQKAQSLLNCFTRHQIAWIDEINNATYYWFPCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0N9</accession>
    <name>A0A061D0N9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765893.1">
        <property type="nucleotide sequence ID" value="XM_012910439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0N9"/>
    <dbReference type="GeneID" id="24562248"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100360"/>
    <dbReference type="OrthoDB" id="10313111at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="269" mass="30164" checksum="820BAD8E28D52757" modified="2014-09-03" version="1">MAATSTDRLQSPETVRDILIWVYGLKQEPHKTNLVNEIHAICEKYKIQTPKKRWEQFVDELAIQCSEILRAIQGNPYGYCYNCKHDIAKFEYPTAHKAEFFPWFNHYLKSLNDRMTFLRQKCREGGEWSNQTYTVEGNKENKSDLYKFMLDLDPKCKTVDCTAARKCSECPIKMGFNEGCLKASGKTGKDLLKELDQLLTEGSPLFVMLALDDAKEGKGIGNLLLRMSMAGIAGGSVAYIATTGAAAPAMATIADTLASFFNSVLLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0Q0</accession>
    <name>A0A061D0Q0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0106850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766562.1">
        <property type="nucleotide sequence ID" value="XM_012911108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0Q0"/>
    <dbReference type="GeneID" id="24562917"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106850"/>
    <dbReference type="OMA" id="YAYLERY"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="110" mass="12404" checksum="E8FDF9AA63504BDA" modified="2014-09-03" version="1">MCRDNSVVYRDLSAKRLKVKDGMHYGADLVIYEGDPRECHSYALIYVKHDGQEIPAQSVVRWTRVAAAAKKRVRNAKLKRFHITSQAILALVDCASATVKYASIDRLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0T0</accession>
    <name>A0A061D0T0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0107200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766597.1">
        <property type="nucleotide sequence ID" value="XM_012911143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0T0"/>
    <dbReference type="STRING" id="5866.A0A061D0T0"/>
    <dbReference type="GeneID" id="24562952"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107200"/>
    <dbReference type="OMA" id="KFYVRFK"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000016">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR94411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="21517" checksum="01B5AF83D5D1DD4C" modified="2014-09-03" version="1">MKKNAAVSSVRKQNDFTKLLMAGYDLELVNGSMQEFNVTFHGPIGTLYEDGVWKVHVTLPDDYPFASPSIGFLNKMLHPNVDESSGSVCLDVINETWTPIYSLVNVFDTFLPQLLTYPNPSDPLNNEAAALLMADKSSYEKKVREHVKKHASKEEWTKARASTTATEEKSAPEMEDDESVTSDLDDAEYDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0V9</accession>
    <name>A0A061D0V9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0100910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765948.1">
        <property type="nucleotide sequence ID" value="XM_012910494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0V9"/>
    <dbReference type="STRING" id="5866.A0A061D0V9"/>
    <dbReference type="GeneID" id="24562303"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100910"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="64"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="227" mass="25197" checksum="5DA8862FBC341DFA" modified="2014-09-03" version="1">METEGTDGFYAQPKELTAAQRKKLKKKLQFMELESKIAEERDSSPDLRAAEDQDLRQQLAAIDKAVFKVLGDGNCLFRAVEHQLTQACERGAELPALSHGQLREKAVEHLRTHRADFEAFIDVHDSSAEGDGDAFENYCKKMAQDGEWGGQPEIKALSAALGCKIVVHAMGVPPMEYSTLFRDPSNDVGPLRSLRAPPTPGLRYASHFTNTPTPSEAIITLQLKYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0W1</accession>
    <name>A0A061D0W1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0105770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766454.1">
        <property type="nucleotide sequence ID" value="XM_012911000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0W1"/>
    <dbReference type="STRING" id="5866.A0A061D0W1"/>
    <dbReference type="GeneID" id="24562809"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105770"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000079">
        <property type="entry name" value="Cell division cycle protein 48 homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="5">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="4">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="243"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="516"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="800" mass="88247" checksum="FEA0DAB58D573488" modified="2014-09-03" version="1">MAKAVENEPGDHEVVADEGPVDLAKRKYLNRLLVEDATNDDNSVVALHPNRIEELGLFRGDTVMLKGKKRHTTVCIVLADKDLDEGKARVNKIVRKNLRVMLGDFIRIVPCSDVPYGKKIQVLPLDDTVEGLSKEALFDVYLKPYFLETYRPVKKGDLFLVRGAFKAVEFKVVEVDPGDYCIVAPDTIIYHEGDPIKRDEEEKLDDVGYDDIGGCRRQMAQIREMIELPLRHPGLFKTLGVKPPRGVLLYGPPGSGKTLIARAVANETGAFFFLINGPEVMSKMAGEAESNLRRAFAEAEKNAPAIIFIDEVDSIAPKREKTNGEVERRVVSQLLTLMDGLKGRGQVVVIAATNRQNSIDPALRRFGRFDKEIDIGVPDDAGRLEILKIHTRNMKLAPEVKLEELAANSHGFVGADLAQLCTEAALGCIREKMGAIDLEEDTIDTAILDSMAVTQEHFNAAIATCNPSSLRETVVEIPNVKWDDIGGLESVKNSLREMILYPIEHPEKFEKFGMSPSRGVLFYGPPGCGKTLLAKAVASECSANFISVKGPELLTMWFGESEANVREVFDKARAAAPCVLFFDELDSIGTARGSGVGEGTHSAERVMNQLLTEIDGVSAKKNIFFIGATNRPNLLDEALLRPGRLDQLIYIPLPDLPARVSILKSLLRKSPVASNVPITYLAQKTAGFSGADLAEMCQIAARSAIREAIAHEEKHGAAPVEGTPEFKYEIQRKHFQEGLANARHSVTSTDLSKFDSFRNKFDPLYKTRGAGGDEIDIDWPEENEMESTMDVIEEDDDLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D127</accession>
    <name>A0A061D127_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0108240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766712.1">
        <property type="nucleotide sequence ID" value="XM_012911258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D127"/>
    <dbReference type="STRING" id="5866.A0A061D127"/>
    <dbReference type="GeneID" id="24563067"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108240"/>
    <dbReference type="OMA" id="KWGYCAI"/>
    <dbReference type="OrthoDB" id="361926at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="320" mass="35562" checksum="30761D3E51E0CBFB" modified="2014-09-03" version="1">MSYEGESGWLIEVDPMPVYEKKSSDVQGNTRSTGALHMASTSTGLSEDGDSSPDATAPLDGKKSMQEYIAEISQLNSAIDEFSKIIQTLALFKYYIRNRKGNTNLEELHKRFNSFSVKCANKVRVIQQHVNTINRDNHDAMSHREKLGFSYADLRARFNMHDASVNRLKTLMETYQSVIKEYTAAAKSIDDASQAAAVANSAPAAVTVAQSLPECNEEALIDELKSKSKDIMTLEKNAKDLNQLFTELNMTIKKRGENIYNLEQQILLSAEQIDKGKEDMALALKARGGQGIYWVCVLIAAATCLLLIPSHIRSAVFRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1F4</accession>
    <name>A0A061D1F4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766133.1">
        <property type="nucleotide sequence ID" value="XM_012910679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1F4"/>
    <dbReference type="GeneID" id="24562488"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102740"/>
    <dbReference type="OrthoDB" id="366633at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="247" mass="27780" checksum="80A44D06D0DF92D7" modified="2014-09-03" version="1">MVYYSLTDAPQNLKEGIDWLVALKGDDAEKNLKAMGEAVHKFLINKPVGKVELPGLEEVKRITKEFLEKPELKDLPYVNDILGKFEGHINKEPSLFAKIFYVDECDYRNILRARRIKPEDIAQDVTEVVESCEQLMEGMKVPDEYESAYNYRATWDSSCSYNPEACAKVFVGIAPMLFVGIGAMLDARYADLPNEAEGAAKVLQAMGFVEPQCRAGIDASKALNELRGVELNVLDTLYDLSGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1K9</accession>
    <name>A0A061D1K9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PROTEIN C20ORF43 HOMOLOG, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766714.1">
        <property type="nucleotide sequence ID" value="XM_012911260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1K9"/>
    <dbReference type="STRING" id="5866.A0A061D1K9"/>
    <dbReference type="GeneID" id="24563069"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108260"/>
    <dbReference type="OMA" id="NRGVLIW"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="216" mass="24062" checksum="AF83D54F6429D732" modified="2014-09-03" version="1">MGGDGGSIPGRIDLVRTSGYTFVRNLGGMGYSPNTQIKAADEHLTSSQIKDLRWKTCSLSQQPLSPPIVACRIGILYNKESVIEYILAKKPLVSMQHTKGLKDFKEVKFKVDPATRRFVCPLTCTEFTGSNRGVLIWKCGCCMSERAFKELMKGYKSQTDAQCPACNATFTYNPQVFDPQCTTLDPLSHDVVVVVPDTLEENYLRAKLMRRAKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1L2</accession>
    <name>A0A061D1L2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavoprotein domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766198.1">
        <property type="nucleotide sequence ID" value="XM_012910744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1L2"/>
    <dbReference type="STRING" id="5866.A0A061D1L2"/>
    <dbReference type="GeneID" id="24562553"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103310"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="25588" checksum="E79FBBDF63A68351" modified="2014-09-03" version="1">MGIFQSSLSDRLRETKHEINRATRELERQRLKYEREEKSLVQKLKSEAKNGRMQNVRLMAKDLVRNRKLALHYANMKSQMGGIMSQLQNAQSTNMMATSLKNVNKLIAKVSNKTDIAEFQTIIQSLGKESEVINLKLDVMAETLDNSLMDVDSVDEEEKIISQILEELGIDASASIPSVNASTMQESGATVPVQAESVGAKNEVHDSPRATSDDPDSIESRINNLRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1U7</accession>
    <name>A0A061D1U7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766799.1">
        <property type="nucleotide sequence ID" value="XM_012911345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1U7"/>
    <dbReference type="GeneID" id="24563154"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109110"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="64" mass="7334" checksum="70C222F0E4249D9D" modified="2014-09-03" version="1">MVVYMSMLYQAQEWSNYVNTLLVLLGFAIYLYKTKSSAYLIPKAVYEWTGYTSSYSGLGSKNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D207</accession>
    <name>A0A061D207_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0109610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766849.1">
        <property type="nucleotide sequence ID" value="XM_012911395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D207"/>
    <dbReference type="STRING" id="5866.A0A061D207"/>
    <dbReference type="GeneID" id="24563204"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109610"/>
    <dbReference type="OMA" id="QPANWYT"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="322"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="687" mass="76769" checksum="79A2309BDB307229" modified="2014-09-03" version="1">MWAAVRAGQISIRYARRTKSYAAYNIDELYNRAKDAIAFTEHERILLNNALLQLSHCQEWSRNLYAKGVPPFLISSAEFRDKFIRHVDHDQDAKQAVRSCMISAVTSLHLPADGTNRKADSITPVCEAIILHLTEYVRREMPQTMLAFHGAKHLADLTNPLQEFPPRPFRRRVIAHLGPPNSGKTHEAHRSLCAAKSGAYCSPLRLLAWEMRQRLSEAGLHCSLLTGQENVSNDGDTHLACTVEMTPLHRDYGCAVIDEMQMVGDANRGFAWTRAFLGIRAPEVHICGSISCYTLAKSLCDIAGDSLEVTEHARLGQIAVIDEPMSIDDLQPGDCVVCFSRGTALRLVENIERSCFKNDGSKPLSTAVVYGSLPPETRTRQIDDFNSRRKCILVASDVIGMGVNVRIKRVIFHTVKKFDGMKRRRLTAAEVQQIAGRAGRYGLDCGNGYVGCMRFENIGYVKRMMEKKQEQLERAVVAPSPVTIAAFADAVQSATDPPATLAEAIQMYRIMAQAGGTFELCDVHALIKVAKALERIELPTQTLVEYLFVPLGSQPALQLVLRSFALSHAVLNTVKIQNVVHTDAMELLQTHGTMIKDENNSEGGQGIRHDVMRRLEMLYQILDAYAWLWHKFPDVYVDYHAVVAAKANISTALQEHLVYLSVHTSTYEENEEDEHGVDADFVRKLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2A0</accession>
    <name>A0A061D2A0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0200380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767067.1">
        <property type="nucleotide sequence ID" value="XM_012911613.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D2A0"/>
    <dbReference type="GeneID" id="24563422"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200380"/>
    <dbReference type="OMA" id="MISCCGH"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="2068" mass="235615" checksum="280CA260424FAB29" modified="2014-09-03" version="1">MTPTSGVKRHCASSSNSTLDVRALGEEYFDNHDRDRVYQEIYGYLYANCNPHKANQLIIEYTGNTGLCTTKWLEETIAFKCYDCESDSTCAICVSCFFRSNHDGHKYRLTRTSGGCCDCGDNGSWDPSGSCSKHNSPLTMADECRLLDLFSPEFLARLRDTLRQICAAITAYMRNLDPVEESFFLLLLTLLDDLLKVTPAFRYAFYEVMLEEDLTVWVRKHQLLSSDVRKTLNSLYLTMVTSMAFKVLFSKVYVQHYGDIVEPYREPEEWHLSHLSVQLFTYSHIATREVNNGFLEVCVQCLLDHHLRDGRLDTLQFPRFDRRLFSFYLLVLSDFTYLMNHDVVVKQVLKTPSLYATLFKLLSCMQMMNTIQHAKDQHVPFENSGYVIAFTSEHTLHTALRPFSENCKSDLTAAIPFYKEVNKCMKDNLKMWEFKSLKLCRTFHIPFIRFFASIVNFNHIRQLHASSLAADVIRGDPLVNAFDDEVLLYVIRTTVSTLRFAQEVKTNLWVYNGESMHDQHDHYRQVILVQLDLVAVQAAVALLGLRRRAGITDVDPLLVLHKEAFRRNIICRNGSLVRMQCTPGDGVFRATFFMHLINVVLHDVKHLEKLSVPRNNKDPEYVRRGYPLVVMDVASALSMGRSEFGDITGMVDSYWRHHPQIADAVESLATVNYSQLTDKAYMRPKSESYRLVDVIWNPYSNASEISIPQEVLKRGTAGMLGPPRSSAFMQPEYYEAQDAILNSLGSKECFNVAWQFMEGLSNLSSHSRYKEMEVDGETTFHNASDDRECYFDVVGEPRQYYRSRINWWGPVGTKWNEAVLCALKTFCLLMETSQHINEENAPRLVEIIEAVSVRMGDDQIIHAALKHVAQKLRDTFKVHQKESSSVSHEDRAEAVKKLQMKFMARMVAQQKKVPLGGVAEKLDVPLEEGTSTLSSKGEARDKSIEEETCILCKQGMDEWRPMSFMCLISTNSVLRRCSQSATGPSVYARASLPLRSSMISCCGHLVHTQCMTEHQMREASGQLMPLYGIQRSTNEFFCPICKSLCNYMLEYIPESKKLRKGKLGKKTKLNTLCMATWRYAFCANWLPSPVHARFNINPHVMYTFNVVLPHNDVQAAPIQGRSFLEDLGVADTQSYEMCCTKCIEADVSVEYRKKCKTLSYRRKFKPPEFDRSGVIRQLEQWLSCRPSKRRQLGRLFDVDPDYTYPHAMTGEYCRGVFSGQRCLYGVQNWRHVDAGMLVDPKFWVLYHHILATSTCRRNQLTVKPSLLQHLVSNFYGVERQDYPVDECGVPCQLDDNFFDMAVEDLAVPFPLRSSMEPVTMTTTLVEALTDDQVRQLASALNFELVEEEPNLDNYNVESNGGKLNLNVTSPWSKDVFRYFLMFFTHRAPTLDQCLKHLANCVGMLSLQVLERFVLDDIKRSFATFVDVAAGVGGNGANVRGPGDSPDATMVDNTAAEAQSASKYGKLRFKRQFLTALYETYVKQHVESADMPANLIERVKWYGLNEHEADFRYYNYTGQLCMASDMGSSGDVASAAGLENADVAEDSSVKSDLMDVDQQAGDVSSHPTTAKGGDMVVDNAGRMHRIPYATVEQIGLDAHTDLALKLQSVHRRTVAMLTYPIPEQPDGEMGAQVRNYLHAVIANLLKVRTVHSLMDSGVDSTEFGLLLDVLRDDTNDCEVSPRGECDIADKLFAEGATRNATEDSPVEPERHYLGTDFLRRVNEEMYRAHSNFAFFEVLRHLVPAEYHLLDFVDVDAHKELTESSTLDDLVPIIRSIAQRVYAHVRERGYLHRDFEPDMDAFVTGLLMHLNRLLDMSFWTMFSVFDVDEDVKTKVSYAHLHPHEVRFGLLAEVIDINKHLQPVRQICEYMFQNNARRKLQYVRATGHESAAPLITGYDYIDMERNLPMGAWDLLRQTTFRACPTCGRTPPNPLVCVLCGSVVCHHSICCDRNKGVRVLRMLTSLERSHVAFRPTDLTHIYNDEVLTHANTCGGGQCVFISPFNCFLLYLDERRHCTSQTLYSDKFGNRDLHESVYGPVVLSRTRLANVVNSFCQGRLAHEIINIQKEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2A5</accession>
    <name>A0A061D2A5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0105410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766418.1">
        <property type="nucleotide sequence ID" value="XM_012910964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2A5"/>
    <dbReference type="GeneID" id="24562773"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105410"/>
    <dbReference type="OMA" id="EWYKGKA"/>
    <dbReference type="OrthoDB" id="364608at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25729" checksum="CC5FCFDB4AC0C6B1" modified="2014-09-03" version="1">MSSYSGAPYRTPDGPLLSAWIFNTTELNYNELNKWNLDSSVFGFHEDLLKDKPKPVIASYDRGSKPSETASIRANRRRPTYSAKCLKAATDEESNGSSSDSSDETATAKDIRQNKILQYRKALTKIVKVKTAIFHEKVRVTCSKDGKCIQWYKVKASEDDENKRQLIGTLPVSKITNFKTKVDNLRYLEISAGNNCYLFMFKTRDEREQWQNDFDSFVKFMNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2P4</accession>
    <name>A0A061D2P4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0200300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767059.1">
        <property type="nucleotide sequence ID" value="XM_012911605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2P4"/>
    <dbReference type="STRING" id="5866.A0A061D2P4"/>
    <dbReference type="GeneID" id="24563414"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200300"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="816" mass="89272" checksum="259A2A2C4E46164A" modified="2014-09-03" version="1">MYNAIRGRFGHSADTYIILGKKPIADGHDREEKTKKNAKVLDESDSESYETNVMYYEQKAKLKGRLADALDSLPEYSKTTVAHEQTINTEESRQVIHGLWNSQISDKFWSTIGREEETDFAFRDLNPSTIDHFVVGTCKVIPEIKAAHFKELIDKVVFKGEAGDSTQSESDLVNTNRLVPNENAHMVIVFGGACPSEKQLRACKGNLSLLSILDAAEDLKVNNELFTVSVRGADPHWKPLASKGCPSARAFHASTIMYTDFATPILCVAGGFGHNRKIMDMTLHMMPLVQKTDHPVWIAITAAGKMPTPRYGHTMGQVHEYITIFGGTNGYEILNDLWVLNLHQGTVDESNRNISNEWIRVEISGPVPAPRCFHASVKIGIQTSNPIIIYGGVTADDSARAYALKNDQFGNLRWSILPVMVTAPQEKRAFHSMAYHNGQVLVTGGEDFTMKTPSVHQCLVYHINAREFQYTKEALPLTGHRSVLLDGMMYHFGGIRNNTSRVSIEPITAPKINATRRAQNASAGSKTGGETRRKSAQNAKEAAGGSKREEKANKSASQQKPGATAKAKTSPRTRTQDIRKKVEVEPEYHTPRETNSDCDMGVSTKPRRDAARRCIQNVEEEIVRRKAQKAAEEAARIQSKAAADEAARKQAKAAAEEAKKNAQKLAEETARRNVQSVAEEAAKMQSQAMAAETVVRHTQVMAESAMIQTQVEAAESATNHAQAAGEYERVNAHAATVNLQNSADETVKANTPNAEDATNKGSTPTVAVDVPMGDIITDAGEGDVITEAKEAPKGDTTTMDDPANVIPQTSAVNVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3G8</accession>
    <name>A0A061D3G8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0202900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767319.1">
        <property type="nucleotide sequence ID" value="XM_012911865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3G8"/>
    <dbReference type="STRING" id="5866.A0A061D3G8"/>
    <dbReference type="GeneID" id="24563674"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202900"/>
    <dbReference type="OMA" id="RRLNVYF"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001311">
        <property type="entry name" value="Dynamin-like protein-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF233">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_59, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="27"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="558"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="733" mass="82811" checksum="E7EBDFDC6328AB72" modified="2014-09-03" version="1">MDDHTGTSLRQLVNLIDKLRDIGLHKYINLPRICVAGTQSSGKSSVLESIVGIDFLPRGDGIVTRRPVEFRLSRLTGKDGEADLRPYIIFEGNSEKFYDFEKARQHIQELTNEKAGVNKGIIDDPIVLSVFSPDCPDLSLIDLPGVTRVPLKNSDQTDDIEALTKDMIMRYARDPRTIILAVVAANVDMSTSDALQLARRADPLGVRTLGVITKIDLMDRGADAVAMLQNDEVPLRLGYTGVKNRSQKDIAEGVTIKQALELERQYFSEHSVYKHIKPSLWGIPSLVDKLTKVLYRHISTVLPDLKAEISNRIKNTTARLEALGASAPSDAAERVHLLWQLTTDFCEVFGGIIRGRYVSRLHDFVDKDAVTGVQIRTIFNELLEPFLSQKVFDQLSDFEIDQAIQMHEGDSLPGFPSPDTFEYLILPQLQKLVPPSIECLERVQQTLDLLAMKVSQRIFARFPLLCEKVLALSQNIFTEETEKSRGFLEKYVESETLYIFTNDGQYMVDKADEKVDAGKSTNYVAEKAAQLTQATGKALSGVWDAAQGKKRRYSSQFIQEIRRRLNVYFAIVLRNMRDSVPKIIGHFLVRKVQQNMQYKIYTALTQQKQEDLEAMFGEPPHIARDRELMREQLDVLNRAMSLMQRDFSVAQRDVDLFDETFDNDLKAFSIKAQQPGSPPPCPADVQRRPAAQQLPEPAITTAHHLPKAQYITPQPQRARDTTRRVVASNPLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3T6</accession>
    <name>A0A061D3T6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0205290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767557.1">
        <property type="nucleotide sequence ID" value="XM_012912103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3T6"/>
    <dbReference type="GeneID" id="24563912"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205290"/>
    <dbReference type="OrthoDB" id="10504891at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="359" mass="40953" checksum="02EB7ACD608A87C8" modified="2014-09-03" version="1">MMHCLVVSIKDGVIYGDSDLINRPISSFFRNRISSKYTRQRIDARMHNTRNHEESTYTVRTKKCVSKNDNSRCYEKKETITNPPVIYFPDLGVTNNQLKGDDDNIILKSISGGIVEYADADSSDVGIEPLYTVVDNVIRPVVNASSPDDKKSVLIDNLYKHDSVSVDYVSNRKSCRERSYDSGIKVEMRKEFSFGYLNSRDNEMAGLLNEEPVRHLVEHIGGPLNGENRVRGYSIEAGGPRIKRSVRVHLQSNEGHEEILTSKTDTRCAKMPDYRRDGSTKFYDDKIPNVVQQGAANVTHIGKFEVPPYAFALEKLKSRFATSKDQNNESETNDTEKADLTKLTLKWLKRLIFNWCRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D453</accession>
    <name>A0A061D453_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0206840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767712.1">
        <property type="nucleotide sequence ID" value="XM_012912258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D453"/>
    <dbReference type="STRING" id="5866.A0A061D453"/>
    <dbReference type="GeneID" id="24564067"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206840"/>
    <dbReference type="OMA" id="KTHHWQI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="189" mass="21465" checksum="437D60F0B93A0303" modified="2014-09-03" version="1">MGLLKVIRKGKALEHEIRVLMLGLDNAGKTTILKRLNGEDTSRIEPTLGFNIKTLEHDGYQVNIWDVGGQKTIRSFWRNYFENTDALVWVVDSADAMRLEDSRSEIEELLSQDQMAQCTVLVFANKQDVTGALNVHEIQEQLGLDRIANERSWRIHGCSGISGEGIVEGFAWLVSDVARRIYTQDYVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4J4</accession>
    <name>A0A061D4J4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0201290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767158.1">
        <property type="nucleotide sequence ID" value="XM_012911704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4J4"/>
    <dbReference type="GeneID" id="24563513"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201290"/>
    <dbReference type="OrthoDB" id="361197at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="3">
        <location>
            <begin position="574"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71874" checksum="FD13A84454FA2718" modified="2014-09-03" version="1">MEGATVGDSPRMAAPLCRDKTAYTQRSPSESSATSLQDSPLVLAKPADELALVQRTVENDQGRRETHLEEPRFRRKAADNRCYIPNGLSSQLFMPLWNAVFRHKKLQKKTVASADVERLCIALLCASKAEDRPFLTVGCHIKGLCIILSHKLEFLAEDCNQLSKKLLMSTAVLAIAARPKQRQSYREDDDYQLPKRKRQSAKTKKQKKQMLALEDYFETGHKARSDIYDEYSHRFNIATSHLRHDIAVDQIEVLQLMNFGIGLGMGTDLAFYSAGSSNVDRDISYHNFEHGLMDGHRPSLESLQQHRETIIPDTFLDLQSLSSPFKLNGYSYTPQTRFSQDASDADTTIASTELTLQSESVTLSTPDFGRYDLDWDIYNDPFQDEGREQQSVSNEGRTGAELVPANNRTRRMVLEYAEPNGKHVHLVKSRNVGRYDTKVTSRTPKAPRKVRITKEQNTLDTFAVTTQPICDKTQWFNSAIDSLVKSVMGCVPEAGDEAAQQPDAGASEKHISVVPPVVKPPSTKQGEKWFKSVEREVSKTKRVQSPRHAFDSETVSTVQLIEGFRTCVRQRENASEPIQLDEVLQGRSKESAALLFYRTLVLANAQFVALSQPAVPGAPIAVTPARRFWEPIQTSRDLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4W6</accession>
    <name>A0A061D4W6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A)-specific ribonuclease PARN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polyadenylate-specific ribonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0103190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766185.1">
        <property type="nucleotide sequence ID" value="XM_012910731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4W6"/>
    <dbReference type="STRING" id="5866.A0A061D4W6"/>
    <dbReference type="GeneID" id="24562540"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103190"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103190"/>
    <dbReference type="OMA" id="LMHTIIG"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="5">
        <location>
            <begin position="265"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="663" mass="74405" checksum="53FD7177B3285055" modified="2014-09-03" version="1">MYASAKLLATGATGSCCVELDAIRALNTIRHVYCWDSWSYAALNARCRRQERCYSVLNDANASSNAITGMLLQRRHGHSAVPYRRNSAHGVKRSFSSAATSRLTWKDHVQEARSALRTCDFVAVDVEYTGLHLKDDRFVGLEKCYEAHASGAKQFVPCQIGLTAAKYLGKGVWKITPTSVYTIPSSNKFFQVSTSTLQFLKDNNFDFNSWIRHGVEHLTPAEERDRKASIELRIKELDQLVNSAPPGTPAAAVEFDLSSLTAEDRSVAEDVIGRIKDWIRSGDNNPLEIELDSAFQRLLMHTIIGQQFPEVYSHSARRGDEKVICIYKSQVELYKQQKLTLQAELARIDEEIGVRALFDEISQHGKILVGHNCFYDMLHIYQTFYGELPESVEEFRKLWTDKFRNTLDTKYIAEFHDAVASTQQSSTLKGLFDHMCATEPTAPGGTTISVHPLPGTSWVLPPAVLPLLAKTGTPAEISADSFKTADGSATVMQSHDAGYDSFMTCVLFVLQSGRILRSKHANWDKLCASSPDGSLNALALLEHIGPSTNCIRLVKSQPNAINLATNREGNMDRYFLMTGYPNSWKKWDIMKVWSPLWVSVSVIDDTSCWVIVKNDEDIRNINLIYRMMKNPQFRLETYEQSRSRKPGTDATLTPVASDDRKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D518</accession>
    <name>A0A061D518_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">14-3-3 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766245.1">
        <property type="nucleotide sequence ID" value="XM_012910791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D518"/>
    <dbReference type="STRING" id="5866.A0A061D518"/>
    <dbReference type="GeneID" id="24562600"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103730"/>
    <dbReference type="OMA" id="KGCQLAR"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="28999" checksum="688DCA220BC199A5" modified="2014-09-03" version="1">MAEEINQRQKLTCSAKLAEQAERYDEMADAMKALVETCISGKEELTVEERNLLSVAYKNAVGSRRASWRIVSGVEQKEANKSNVVQQNLAAVYRAKIEKELTQICYSILTLLNERLIPATADSESLVFYHKMKGDYYRYLSEFSCDLEKVQASASAKESYQKATEIAETELKSTHPIRLGLALNFSVFFYEILNKPHEACEMAKRAFDEAITEFDSVSEDSYKDSTLIMQLLRDNLTLWATDIQNDGTGDKPKADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D551</accession>
    <name>A0A061D551_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0104080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766285.1">
        <property type="nucleotide sequence ID" value="XM_012910831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D551"/>
    <dbReference type="GeneID" id="24562640"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104080"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="450" mass="50568" checksum="E565AD19C8632035" modified="2014-09-03" version="1">MAVSAAENEQTYQAASDSTDCNSHAKHNEDGNEGMLMDISEMKAKLEDKMETRESLQDINEMKATLEDMREMMKSLKDMREMMESLKDMRETRESLQDMREMMASLKDMRETKEIAETIKSLVHLLQRGTLHKDVVVPCELKTPHPDGGEGTSPSGGGQQQLCSDPPQLQHASLQAQSGNIPEICVVKKSPNLTAHQHAVYKSLIYVPRNFKEAVDWLIAVRGDDGMKNLKALGAALYDFYAHMSGRFTEVSDLDKVIRVSREFLEQEKLKKRRSVKRILIKLNDRLRKTPDQLAKDTGSADDTENEKYLQKKGLTADTIAEKLCCVVDACAEFLGRIKNRSHYKSAYSPQATWDASFSAHPETGVVIFVGIAPMLCASISSLNAAVFAAMLRFPPFIAYKRMQELIQALGYVEPECRAGMTASYVGDALEGFEETIIFLYELAGFWIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D587</accession>
    <name>A0A061D587_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766320.1">
        <property type="nucleotide sequence ID" value="XM_012910866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D587"/>
    <dbReference type="GeneID" id="24562675"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104430"/>
    <dbReference type="OrthoDB" id="366484at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="253" mass="28572" checksum="83A4D76CFF4AE5A3" modified="2014-09-03" version="1">MVYTSLTDIPRNLKEGIDWLLAVKGDDAEKNLAAMGAALYDFLVDKPVGFTEVPALENVKLISKEFLERQEFKDMWPANELLGRFNNHVKTQNIDHLKYPFPINDSDFSNVVRARRAVPEKIAEDLGRIVDGCESFLEHIVLPEQYLSAYNSEATWDASCAKDPEACAAVLVGIAPMLYTGLYYLRRTSNPAHLKASLSRDVKRPREHLKVVGFKELECHAGMTGSDIRNALEGLNLQIMEKIYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D598</accession>
    <name>A0A061D598_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TAFII55 protein conserved region containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0104530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766330.1">
        <property type="nucleotide sequence ID" value="XM_012910876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D598"/>
    <dbReference type="STRING" id="5866.A0A061D598"/>
    <dbReference type="GeneID" id="24562685"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104530"/>
    <dbReference type="OMA" id="MWEWPDG"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="135"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="351" mass="39141" checksum="6FD9B6CF85BEECE3" modified="2014-09-03" version="1">MSDNEASVESSLVDGQSDVTSVPATAAAELEAPDSAQDDNSAYEANQDAATASGAVASGPPSEVLAQPDPNPPKLQGFDEIIKGKLLARHGIFGAHEIYEEVLFNKPAKSERHSSKRLQYADSGGACDFSDMGSIDKHCIIRFPPDIAEVIRERSAANEDTGVSIEPTGRYDYREFVVRVRGVPVELMGILVELPCHLEAHKTLDCDMLFKAADVSQMIVVQERKEAEVTVEAMRQCMWEWPDGITPPTKNIRKRRFKDLDVYNNEEVKEAEREALNLLNGTVRDSYHYEVKSAQEVRELVESYRNGNIKERIIGLDEDVQEYIKAVQQFEPAPDDSEIMFNGDHSCFMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5C2</accession>
    <name>A0A061D5C2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0104730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766350.1">
        <property type="nucleotide sequence ID" value="XM_012910896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5C2"/>
    <dbReference type="STRING" id="5866.A0A061D5C2"/>
    <dbReference type="GeneID" id="24562705"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104730"/>
    <dbReference type="OMA" id="MQAFCIA"/>
    <dbReference type="OrthoDB" id="430309at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="557" mass="60430" checksum="189AB22F7B3CF067" modified="2014-09-03" version="1">MDVSHPELLWIVITSGIVSGFLALAIGANDVANAFSTSVGSGSLKLRGAISIAVVFEILGAILLGGSVTDAIRTKVLNFGAFKDAPQDLAMGMMCATASAAIWLLFATLSGMPVSTTHSIIGALAGFGVASGRVNSVRWMQMFYIMLSWIGVPLLAVAVSCTMYLLLQEAILKRKKSYKVLYCSLWLLLAITAIPLVVFLAFETPIMKVKAEEGLLHDYQQWFNASNGNKAAVVVIIMTCFLAITVPFVYICGSMRNKAGWSFLENQNDTNKELGVKRNSPSRQISSEGRSHSMELKVGRSKLEIVDISNIGTSRSAYETLLQSAIDDEERTQQVVENAKQTDNHKTEVMFSAMQVIGAVTVIISHSANDTANAVAPFATVLMLYMHGVEKSNDFTPWYILLAGGLCMACGLALFGYKVIKTVGLKLTRVTPSRGYTIDTTAGSIVLILSQLGIPLSSTHSTVSSILGVGLVENLKTQELHDEVPVIELKPPSHKIWAKFPILKRITTNGVNLMLYRKIFVTWITTIFCSGIMSAIIYIVVIFCHKLISGRDGTPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5I5</accession>
    <name>A0A061D5I5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0211330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768172.1">
        <property type="nucleotide sequence ID" value="XM_012912718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5I5"/>
    <dbReference type="STRING" id="5866.A0A061D5I5"/>
    <dbReference type="GeneID" id="24564527"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211330"/>
    <dbReference type="OMA" id="KMEDQEY"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="154" mass="17603" checksum="CF295862BBD0068A" modified="2014-09-03" version="1">MPKNKGKGGKNRRRGKNDNEGEKRELVFKMEDQEYAQVLRMLGNGRLEAYCFDGNKRLCHIRGKMRKRVWVNAGDIILVSLRDYQDSKADVIAKYTPDEARSLKAYGELPESTKINETDLYDEEGDGGIDFQDVSSESEEEDGKADDKFDIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5R3</accession>
    <name>A0A061D5R3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767528.1">
        <property type="nucleotide sequence ID" value="XM_012912074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5R3"/>
    <dbReference type="STRING" id="5866.A0A061D5R3"/>
    <dbReference type="GeneID" id="24563883"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205000"/>
    <dbReference type="OMA" id="DECCGED"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17335" checksum="DAE7B93172D374AB" modified="2014-09-03" version="1">MTFSSDEDSSQESLMSSRKKSITWDEKTISEHDKERGTRTKITEVSTPFCYMSDADSQDDSGSSYKDSDAQELTKELSDRLDAIKNSQDKKSRFEELRKKHYSREYIRHRVHHGEEQSSDDEYHHDQCKEPNDKFVNYSTFDDVTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5Z3</accession>
    <name>A0A061D5Z3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767623.1">
        <property type="nucleotide sequence ID" value="XM_012912169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5Z3"/>
    <dbReference type="GeneID" id="24563978"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205950"/>
    <dbReference type="OrthoDB" id="367016at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="310" mass="34110" checksum="C4AAADD80F163BFF" modified="2014-09-03" version="1">MILLSQILNVSELSKDLGPNPKITKTGVTHDTLMDKIRAELAGLKVIIDTEFLIFYDSSAQDQMPRYKGVNRYYFVKSLLKSMAKKYECVAGFLATATNETPEKVKEKIIECKFAVADNIRVDANINLNWLRMLSKAFYDKDGAIFRVLKLFDEYEAAASNQPLTDDSHPLSKFIVEDQYDNRGDPLSNMDKNNADMEIKIPDTVSVVSPSMEENVCDTVSREDNGAVSMQTNQEMDHHSPMPNSREASGSPALPVQEVGHTEVPPAPTPSQPSSTSLRTGGAEGSSQKASSAYDSFVTLLLAVSAVFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D638</accession>
    <name>A0A061D638_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptin subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0106930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766570.1">
        <property type="nucleotide sequence ID" value="XM_012911116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D638"/>
    <dbReference type="STRING" id="5866.A0A061D638"/>
    <dbReference type="GeneID" id="24562925"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106930"/>
    <dbReference type="OMA" id="FLATAKC"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="7">
        <location>
            <begin position="716"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="835" mass="93157" checksum="06FC685D821E447D" modified="2014-09-03" version="1">MISLPAVAMDRLGLGPPKLKPDFFVDHRKGEVGELRLLLRKMAADYKSASSLSAYTHADNNTRRREILKRLIRCMTLGVDVSRLYTEVVMVSHTADPVQKKMIYMYLSTYSKDNPDLTVLTINTLLKDIENVDPVIRCLALRNISAFGTKLSNDYAKDAILKKFHDPADAVKRSAIIGGLRVYKSQCAIAKKEHADESDCHEHRSAILQHLVSSLKSLNLDVMFDSLCVYSEMLGQGDDIKLSKHSIVYLINRIKKMTEWQQCLTLQLLHTYTPAGDELFDLLNLLDELLNYSSTAVFLATAKCFLAWTAHDDMLQLEVIRRVEMPMIALITHSCDEIAYNLLLNTLLMIVNAPRLEDDSGAGETYKPPFADHYEVFFFRYDDPSYIKHVKLNILVAIACEANYLEIVKDLNEYVSDTNHAIAAKSVKAVGIIALKFPAHLEFIMSQMSVVFSLGISYLISAALYVIRALLLVYPSGVAKLLEIVEASRDFFREPQALSYYIWILGEYGESVEHAPYTLEDLIDRPDISDIAKELLCASMKVFFKRPPEMFPGLSRLLRRVMSEIQDPDLVGHADFYYVLLSTDLAAAEKIVMAPSSHDAASVLENCIVDLGIALPSVHWLDSFNSVHAFDEDLSQGSSPSRFFPFTYGDVDTDILMTPAAAESPEDSSSCADSSYNTVEGYDLPGAVSTDENAAPTTLQDRLAPLHLVVPKTLLSEEFQKSWFACDAICQSTDEVASAHADVNFESLEDLLFDVHIATLASGKSQNTTKMYQYAQNAAGQMYYMELTLTPVDGRWKIQASVKSQRAGCDEALLQSFADTLCNCASNWVSGDDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D697</accession>
    <name>A0A061D697_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP synthase subunit E containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0301210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768402.1">
        <property type="nucleotide sequence ID" value="XM_012912948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D697"/>
    <dbReference type="STRING" id="5866.A0A061D697"/>
    <dbReference type="GeneID" id="24564757"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301210"/>
    <dbReference type="OMA" id="QHMMAFI"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="23639" checksum="C64277BCE38393AE" modified="2014-09-03" version="1">MVNFILNEAKDKAEEIESTAVEDFNVQKMTLFQQKKDEIRAKLTKKINGLKLEKIRTYNAASREIHDRVLRHKCSIIDNIKSDALQKIKEQISVADEYKRIIVLLIIKGLMSLACNDVLVRCRKEDVTIVKSSIGDAKLRFATLVRESVGAKLELTAEVDTNTYLSSDNIGVVVTTSDGKVECDCTLNSRLDICCEKLIPKFKTALFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6H7</accession>
    <name>A0A061D6H7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0108370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766725.1">
        <property type="nucleotide sequence ID" value="XM_012911271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6H7"/>
    <dbReference type="STRING" id="5866.A0A061D6H7"/>
    <dbReference type="GeneID" id="24563080"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108370"/>
    <dbReference type="OMA" id="FYINLMF"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR94539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="228" mass="26399" checksum="791D7FC68E2CD79A" modified="2014-09-03" version="1">MKNYYAILDIAKTATQKEIRSAYIRKAKLYHPDVNSTPNAAARFKEVQEAYNTLYDREKRQAYDASHAFGSASSAAGSRTASYPGAGGRGSRYHPHHDTSSSFEDQFRAEAEQLRRQWHEMETDKLRRGAEKFKTTFTSDGFPGGVRFIHFFSFTSPYKLRFIFYLLRKIAPLIILPLSFLFFCASEVMSNIARKNAKIHIVYDSYGRAYTYDVHGRRCRLPEFDRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6K6</accession>
    <name>A0A061D6K6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZINC/IRON TRANSPORTER, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0302000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768482.1">
        <property type="nucleotide sequence ID" value="XM_012913028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6K6"/>
    <dbReference type="STRING" id="5866.A0A061D6K6"/>
    <dbReference type="GeneID" id="24564837"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302000"/>
    <dbReference type="OMA" id="QECGIIG"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="353" mass="38531" checksum="B971B129114831D2" modified="2014-09-03" version="1">MNVGVAKFLSAVLIGFSGLLGCLIPYLVVYFSKGNTDLKERQDAIDSRLCLCNCLGAGIIMGMAFLHILPEAVAQCEEGSILWKLGHGQFNPGYFIALMAFCGMLFIERVLSSGRTPCSAAFNACQVPSGCCGFEEESASCCESASRSAACDMERAQMEHHDDYIEDDAPRTVASIGSRFRHRHNRLLSKIMRVLCPLCQCNGLCITLALFIHSLFEGIVVGLAESHWNLWLMTVGIILHKWAAGMALSSFVSSNSKLSAIVMQTIFCMSSPLGILIGGIASGRSEFRFAIVNHELFCHMHCRKTAFWKWLCVFAGMMFIFGTALLEVAFSGGCAHSHVHDGCTEHAGHAHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6P7</accession>
    <name>A0A061D6P7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0302650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768547.1">
        <property type="nucleotide sequence ID" value="XM_012913093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6P7"/>
    <dbReference type="GeneID" id="24564902"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302650"/>
    <dbReference type="OrthoDB" id="10438374at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="238" mass="26477" checksum="BC953CCED71CF320" modified="2014-09-03" version="1">MAHNSLTDAPRNFREGIDWLLALKGTDAEDNLKALGTALYDFLSKPHPGSTQIQSLENVKNASKTFMADQEFKDQKPIQNTLGMLIGTVKRTPGEFTNSKRLTAETIAEKLSNVADACDQFLDDIKDHNQYNSAYGAEATWDASCAKDPEACAVVLVGMAPMLYAGIQSLRKMSNRGMWLDQNYVECKRVRALVKAFGYDRLEVRSLMTDSYVSWALRSINKKTLATLKDLAGICAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7B6</accession>
    <name>A0A061D7B6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MT-A70 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768619.1">
        <property type="nucleotide sequence ID" value="XM_012913165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7B6"/>
    <dbReference type="STRING" id="5866.A0A061D7B6"/>
    <dbReference type="GeneID" id="24564974"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303370"/>
    <dbReference type="OMA" id="ADCRMQN"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF2">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE MT-A70-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="779" mass="87864" checksum="3658DF287FB05DE4" modified="2014-09-03" version="1">MSRRGSRSRSDSRRRGSPSSRKSSRRKERDSRRSRDRSFERSSHWKERVSRRGILASSEKSASSRKAREEQRFLEVGDDSHVFSTLDLMFVVGKHLLKLRDNEELPLNVYELRRRMSDYFEGPHRLRFSTVCSINVLSNLLKYMHLGTVTEQEQPAAKVPPESQGETPRSHDHGSRTESAHTAEDSALSNADGVSVAESHATNDVAGVEGVPDANGDADKEDTVDNKVEPDNDGNTGNGEGVAGEDKAAEQPSPLEVYLDGLPEVSDQSFRDVKFHHSLVQLELQHGVLRVMDVRGQLLKRILLRNRKKQRVVDVADALATESIITTGRDHPSREDLDTSRSATVDDYDLTNLTGRVYPIKGGSKKAADDADEMNVDDNIAVSWQTSTDTETRGLQSGKGRGGSDKDGEDTSKELGRDVRRTEGMRESGRGTSLSARSDDPPYDLDGLYKVLYQTPARELKRIAHFQLKEQSGFREICTYGTRADCRMQNYMSLMCNKIHFKRIILPNTLVQLGDCSYLDTCRHIETCRFVHYQVESDIPPRAPVDEVSQGQWICCDVRKLDFSIFNPFVSVVMADPPWDIHMDLPYGTMKDSEMRHLKVQNIQSEGLLFLWVTGRTLEVGRECMEIWGYRQMDEIVWVKTNQLQRIIRTGRTGHWINHSKEHCLIGIKGNPVINRYLDCDVVVSEVRETSRKPDEIYGIIERMVPGALKLEIFGRSHNVRNNWITLGNQLDGYKLTHPEIKKRYEEILAKGDATAAAPANAPQPAADAANTSNPETVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7G5</accession>
    <name>A0A061D7G5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0111170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767005.1">
        <property type="nucleotide sequence ID" value="XM_012911551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7G5"/>
    <dbReference type="GeneID" id="24563360"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111170"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="8591" checksum="7F27AED287FEC867" modified="2014-09-03" version="1">MSRAACLAMRFYLPSSPSFYIAEGYYRYSCAGSSVFQSGLDDTWADKIFLMADTAWRPAWQKLFLAINNFCAPIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7I1</accession>
    <name>A0A061D7I1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0111370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767025.1">
        <property type="nucleotide sequence ID" value="XM_012911571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563380"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111370"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1343" mass="149101" checksum="873F74E975DB2DD0" modified="2014-09-03" version="1">MVTAAMTLTGLVTQVEGHFKVLKEKAGGGARSPGLLQDWGNIKEGIKELVNREIVGGDQGLTAIVKGVEKFGKNFDGKMGEGGMEDKKFQGVLQDWLEDILESGPVKMYIEACGQYVTNNSGEFKSPYGVAGQSELMQKLTKGITNAIEAQIGTSEIEVAQNFINAAEGVKNSIEAYVTGVQAVCKAFAERLEIELTATELDGFLDKIVMAMEKDLVVKTSPTHNSDTKAYFKAAVNIILHQLVGVARGVGDEIQQFMSMSKLGNVESAITNASDVVNRLGGDTSSGSVGKNFNQSLWDVKEKIGELNPILKEDGGSLKSQINDITVEITTKAITEMSTKITDTLKLLTRTISDAAFFANKKLENLKNFKVGKTPNKGELQELQHSFNDLQRPVAVALDAAKKFLGSVDHSGTATIQALGRDVDSQVESAKKALITEAREQYVTSLQGLLVAFSTKAETELHPLPGLITKELDLGVKGFMNKIEKYFIGTDKGIKVIRDIKTTHSRPEKSPLSQAAERAYNASRRLCHYLKSQTDFISDFQKYEPLHNSLLTLLDGLKTSEHFNHQFRDNLDTVKNTLDQLAPRQFGTSSTVMLQALKGGIAALVDALDKTYVSSYSGRQWQEAELGHYAKICWTITPILYQELTTLKHGLEYENWNDHKIYHRADSNSSLHALFFRDNGYDVHRPPNAEHGELNHKRDFNGSNILKHLTNAHELFSQRSSPVIGIPQSTSGSDELGVTVAEESGLIRKLYDLLKTYFRVCHLTLVNKPKAPCSVYEILVWCNGLQFNPVYEKLKAQVQSEFMKDDKERPGTKTLQPFDAHPSDFEHTHIYEALYKVSSDSHAVLTAILGHGHKDGIYACEFSSNSLKLDYPSNMIQLLCTLFDLLKRLYHQLYFLLQQCKHNAQLSGWSDCHYGRYIGGSGWQCNTKQCPKQDCDQRHDQSGNQRGGQYPSCGVKSPLQSFLEDGLKGHLPHSVTARGSSLSCGTCGGTPGMPCRTPMGFADIGATASHTMIGQDICEVLYDFCGSAKSPLTRLCGYLNCLLPSAPKTLADMFSFYYHLTDRWGMSGNGHKREAFEDKVNAANFGRPYGELKVYHLFTPSHSALKKGHSDGSLGSLVCSSKYSVVCGPYLRPITHAIYETFSSKHADKYLSWIVYLTATFYDLLKQLYDECNSKCGSRGSNCHEKACIKECPTTSKHDPPRYHDRNCKSIVQCNYTLPTLAKYGFVLGDPERLNGSAGIEKKRTCRDFCYVFAEAFEKDSHLVQFFKAIDKFMFTIRAPFLWMNVALWSLSLFYLICVMVGRLDVLHIRSHLRTPSSHKITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7K6</accession>
    <name>A0A061D7K6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apolipophorin-III superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0305850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768867.1">
        <property type="nucleotide sequence ID" value="XM_012913413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24565222"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305850"/>
    <dbReference type="OrthoDB" id="10398121at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1545"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="522"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1607" mass="181499" checksum="91174CDCDB7E608E" modified="2014-09-03" version="1">MAPKQLTQCPENLREAIDWLLQNKSEGNLPKLANAVKDLIDQAVEDARSSLISNKNENACVEVTAKDIELCELLKSRLELLHKHEKNLENFFGDKDSGINPLAAIIEKVCSGFEHLLGYDSGNYTGRGIVYSDCDRLRDAVLMYLHGVLESVKMDPSIQVYMPVSEPILVVVLNTLEFSAGKGSTRFTESIGEVTKWLSNFEKIFTALTNAAITKFDDIKLDHIEGTKGFKKALEALNGASPSKRNAVFAALQKCLKKANELESTTLKKALEAIEVLDSDIKNKVQKSVMQVETLVKAFAQSAQNTSLLEVLAKVDETLGRLPVEVERKIKNGGHETVEQFRAKMEMLHGGVNTLKDDQFNELKKSVDSGIKNYGDKVSSTMNTVSRDYKNKIIATLTTVVAKVSVLSTQLIDAQAEELEKELQNQLESLPLTALRGQFVKNETYESLLKRKKSEIQSIRSQLKSENLDEENIHQYKSKISGSISKVLDAINRTNSVWQKEIQQQLQGLHKDVQNVHTIKQQAESRLLLARLEKQIDCLERLAKMTGDGSVKDTLKTATSNVSKLNQELERTRVDAAFWLNQHRDYLKDAFQNAQQASNKLAATIKEKNSQDPAVNSTSVFTNSKIDELLKKFEDEFKGHIKDLIEKVGMKSTDNNSVHKLLDELQSHINALQHAIRSLTDHVSIVERSLQHWIGKANRDLTSAFHEAKEAITKLGQQMKTEVENALTDIIKEAKEKYGQTMSANLTELNDNLTSEIKNIKDIIYEDFNHGAKGLLRQLNSFVNGIDIIKDIKTSTYQILDAPRKSSLSLAVLIVKIGFKRFIKGVSEQRDVKSEKSKIDEVSQSLDKLLQQIYTSDHFDNDVNIMRDRFIDTLNALSAETMDDAPKRVLKPLKYGLEKFVEELNKAYVSTYSLQKWNDADKIKYAKVFCSVLEILYADLDILHSECNARGTWRDTRIRLNEQNNKENLLGYFLKKCGYRVASGHDRQDGELQNKTDCTGQSILKRLTNDKNVFNSPNNDAGNLYNLYETLYTYYNICHCKYFPDVKHPCTVKDMLIWLTGLWHHPMLDPLKDHIKEILVAPEKYKNSNYLSIPIEELKLDPTSTVTAKMIFDTLQEIGTQSHNVLTTILGYGGQSATYACDFANNALGLHYPSTGDECLHTLLDILRRLFPVLRFLQSQCGNPASDYGWFQCRYGKDIEPANWHCDDHSTTKVDCNSRSPLMSYLSDCLPGYLPHQLTSIGCDPVCTTCSTSEKGMPCLLPLGFRAFSGRTRRGSDIREILDKFFNIPNHSTLFCLVATPPATLPEHFGFVLSIVREIQSGGTPPLKTAIKSTIIDSSIGIYDELADLTSALRDTYGSEYVRHNECVHPHLITLTSSSICYGESKKIHWAPYLRSLCTDLYKHLANRNSEPYLSWVLYLPWVFRDCLKNLHDAFNHISCEDWSCLRCLDGDGCRSGQHGLVEQAEGQPARPCCQCLSAVNCEGVLPTLYKYGFTFGDVFTLKDPSTRRSCSDFSNHLRDVLDSEHFGNLFTKCDEYLFKTRGPFIWTLFALWILSLLYLLYVLLGSVDTFYIRSHWRSLSSHNIYAQSLLAASRGNKIAKLAYLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7P9</accession>
    <name>A0A061D7P9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768203.1">
        <property type="nucleotide sequence ID" value="XM_012912749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7P9"/>
    <dbReference type="GeneID" id="24564558"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211610"/>
    <dbReference type="OMA" id="HECATTM"/>
    <dbReference type="OrthoDB" id="365886at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="325" mass="36438" checksum="73877958664598F3" modified="2014-09-03" version="1">MHYILHENGGGVGTRNRDAAGVYRLQGAVDAAHKNIAELHHCTRALAETLNRSHECLEELLTLLPQCGVETDMQPQLCGAKSAKELNYQSLREASDTTRALCHKLRGFSDMHLEKALDKIQEFAVTDTPERPNLPVMIGDRPMTPNELIYTLNEAPMVSVAHHDREACLRKNITQAHYELASSKVAYKQLLQCSELPPSGSYIIQMAGDRIERTLRILSRSIRELIAIDPAYQDFFYAYLTETENKEKEHSSEYAVVHRIDSQAIKSMLSSQGGKGNGGVAKMYEKQLHECATTMGSLMQEFIRSFSPNTPTEPTDDLSVQEMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R7</accession>
    <name>A0A061D7R7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0100890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765946.1">
        <property type="nucleotide sequence ID" value="XM_012910492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7R7"/>
    <dbReference type="STRING" id="5866.A0A061D7R7"/>
    <dbReference type="GeneID" id="24562301"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100890"/>
    <dbReference type="OrthoDB" id="361299at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="3">
        <location>
            <begin position="90"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="182" mass="20488" checksum="78BF32E3F98059AF" modified="2014-09-03" version="1">MARCFSAEKWPSGYSFTSRCSSGAYLLCVRLLRAGRWILIACAVRPADDPFTATQPFVSKELRVKFGCLTAAVFLGIELLGRLNVTEERLILLKGFGLQMESRSLFGKQSIRTLPISEISDMLINEAVMMDEVIFYMLITLKNSDEIVLPFENAIPRLKGLRLIHSAFNEMFPAEMRRAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R9</accession>
    <name>A0A061D7R9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768774.1">
        <property type="nucleotide sequence ID" value="XM_012913320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7R9"/>
    <dbReference type="GeneID" id="24565129"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304910"/>
    <dbReference type="OrthoDB" id="365998at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="177" mass="20633" checksum="E56F08622BFE1007" modified="2014-09-03" version="1">MDLLDFIASRDVLKGNKAESDSAQTSPYRDYETRWKELKRVIRAENAKKNPCHVTLKRATDELRDIRRHLLREDARQSGRPQPVSCLGNSAQRPKPDAYKDWSEAPKIRQRNRNTRRFVFYMPAGKEMGTDVTIGRERLEKIQETVNRRSYGPLESGPKVAIAGIPQPMDRMNRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z1</accession>
    <name>A0A061D7Z1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0101440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766001.1">
        <property type="nucleotide sequence ID" value="XM_012910547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z1"/>
    <dbReference type="STRING" id="5866.A0A061D7Z1"/>
    <dbReference type="GeneID" id="24562356"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101440"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="487" mass="52440" checksum="E6BA80F12F90782A" modified="2014-09-03" version="1">MADSSGDKPTHLATTVSFGKGEEGNEGICGTYKGSTKIEHEGTNEDEMSSQGAATRRILASKEAVKRSILASKEAVRRRKLESKEAATIGLLESKEAVRSVLLASKAAFRGGPFSSRDACMMNIRASKESVGRRILASKEAVRRRKLASKEAIRRRKLASQEEVIIDIHASKKAVIRDIHASKIAVISDILASKEAVRRRKLASQEEVIIDIHASKKAVIRDIHASKIAVISDIFASKDAIIGDIHASLAAGIRDILASQAAATSGTLAPQAAGIRDIFPSLAAVAPPPFIPQVPVARRESLPQEAVAGATPSSEIAGASGKRPHAEVTRGILASNEAVRGDTISPEAAGSGAGKDDSEAGYKDKCRKTLRKFRKPIKKRFRFRSEYDRNSSSTSESCGSRNMEQVIIDTANYAEDISTFVKHIAENLDRLIHFGPPPQKHHSERDKNDNAREDVEQSSNDTFSAGSEDGTEDLPPEDHNSESEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D805</accession>
    <name>A0A061D805_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA2/NAM7 HELICASE FAMILY protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0305820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768864.1">
        <property type="nucleotide sequence ID" value="XM_012913410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D805"/>
    <dbReference type="STRING" id="5866.A0A061D805"/>
    <dbReference type="GeneID" id="24565219"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305820"/>
    <dbReference type="OMA" id="DENYDYC"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="313"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="524"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="609"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="988" mass="111642" checksum="B8F796B891E73571" modified="2014-09-03" version="1">MAITAEAEGFRTENDLLERVLSVDFYRDLPKDIPNQLPDVQSSIRWDTPLEPLPIQFENVETYQRSFFPLYMIECLQMLASSKYMSMAYPLRVSEVGCNKSGRFVEITLKSSAVMPFVCGDIALLYVGQPGHDIVPKNDAETMQVDTLPKDADEGPAYVVVPDDHPLYQDTLKHALGFVLEAKRRICTLQVLAMPPRFCNPKTFDIRSVERLEAIQELILWSRSKSGSKKFSGMGRGDSDKEVWYLSKLCSFTTALREFQALRGLPRMPLQEKLLMGSVEPPQDQPVSDMDKDTYLEGIRIPKMLRKSLEASYNAAQLRAIRNSLNSNGITLIQGPPGTGKTTTIIGIISAILEQDFLPYDSDAKTEPSTETPGTSDASQINKPAWFKYIDGNNMNEPLEIAFDKLSITDTQTTNGTHRYDSYACMKPAKSSSSEKVRVPTLRHSRRRILICAPSNAAIDEIVRRLVRPHTGGIFDADGNRLNPSVTRIGPNFHDDLTVYSLNNKIDMLGRKKYGHKFPQMKNHFRSRLVTETLLQSDIVCSTLSACGSMDMVKNHAMFHTLIIDEATQAVELSTLIALRLGCSRVVLVGDPCQLSATVCSNVAVSLKYDRSLFQRLQMCGYPVNLLDIQYRMDPGISRFPSMYFYKSQLKDAPSVYQRQQRDWREFPLLRPAVFYAIDSMQSKDETSYKNEMEANLVCQLLDMILTVLKAERGYKPELLEQRIAVITTYSAQVALLKETIAMRHPQLVAPPVEKEKKKKVKEPVPPGPQLPKLLIDVSTVDGFQGMEKEIVIFSAVRTGYVGQKNAAQKTLREITPPNVLTIDNEPHDPDAAQQFANQMQEYVDGILTGKTTSTIPDVVDVSFIADRRRINVAITRACRNLFIIGNPRFLLRHTHWQALYHHYAQCGGVFICKPERGKMRENYLQTWGRDYLLRDKQARKRYLKNPLLSKLILKIMGWDAKTADEEITDQQPATAQQANKTPANQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D810</accession>
    <name>A0A061D810_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0305870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768869.1">
        <property type="nucleotide sequence ID" value="XM_012913415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D810"/>
    <dbReference type="STRING" id="5866.A0A061D810"/>
    <dbReference type="GeneID" id="24565224"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305870"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="12">
        <location>
            <begin position="112"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="10">
        <location>
            <begin position="219"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="13">
        <location>
            <begin position="457"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="606" mass="66729" checksum="355B98C8C431411C" modified="2014-09-03" version="1">MESKPCGTIYKVSGPLVIAENMPGTKMYELVHVGPQNICGEIIRIDGNSVFIQVYESTSGLRVGDPVKNTGMPLSVELGPGILDNVFDGTQRPLHRIYDAYQEYYVPLGVNMPSLDRTKIWSYTPNPSITVGSMVTGGDIFGTVEENDIFTKHHIMVPPNVSGKVTYAAPAGNYTIEERLLEVESLGEVKVCKMYHVWPVRQPRPIVKKVPSTKPLLTGQRVLDALFPAVMGGTCAVPGAFGCGKTCISHALAKYGNTDITVYVGCGERGNEIAEVLKEFPELKTTVNGKEVSIMKRTCLVANTSNMPVAAREASIYTGITLCEYFRDMGYNACMMADSTSRWAEALREISGRLAEMPADSGYPAYLASRLSAFYERAGSVECTGTPSREGSVTIVGAVSPPGGDFSCPVTAATMSIVQVFWGLDKKLAQRKHFPSVNWTTSFSKYEKQLENFFEESCPDFMPGVKVLKNVLQKEGELLEIVQLVGRDSLSEDQKVTLEVAKIIREDFLQQNSFTDYDYKCPLYKTAGMLNCIVSFYNECLKAISESGKRGHKLGWGTIYNTMRATINKITGLKFSDPLMPEEEFQTTVKALNEEIVSGLRQLIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D876</accession>
    <name>A0A061D876_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769067.1">
        <property type="nucleotide sequence ID" value="XM_012913613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D876"/>
    <dbReference type="GeneID" id="24565422"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307850"/>
    <dbReference type="OMA" id="SACCITS"/>
    <dbReference type="OrthoDB" id="366456at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116624" checksum="5CB001422D846A1D" modified="2014-09-03" version="1">MTQHLGEGESKGLKKIKSDMESLKNNQGKGITDNLGEMSSAIQTAGAYAGWYLGQLETPHIDRKLKGIQDGLDNLRLTDLAEAITMCDNFLDKADEIERNTIDALLKHVDNEVYDAIKDLTKEARGMYVDSVREALELFAKKVNGDLEKMQNEINRDRYMGYKGFMRYLHRPLSSDLTGHEQSVAELSFAFQEIVEQMETYLQGEITRLHDEQNKEKNPSLPPMEEPYTPKLNDVYEALTSLLDYLRDNDGGTDKLTELVERLTNTLSNLAPSDFKHSSTPLLDTVSLGLNKFAAEFHNSYISAYSGQQCKDEHAHKYAKVLLSMIPMTHKALHKLATKCENEWKYLHVSMFTADDRDNALGNYLTRCGYRVSSSDSGQDGELNNMFTGGGIYEVLTTPMEGVAIEMMIDNEPLKNVINLVHIMSLLHNLLCRYLQVCHLYVPPEPRYPCTVRDMLSWLSGLQYTQVADKLPGHCKALLNRRCHDGDLPNKEDPVMAKCIGELPYTIASACSRSTALLIAIQGNGHGFDLAAYPYSVDFSNNRAKLYYPADPDALLDMLREIACRLCKVLHFLYSQCCRSTARVKGWRECAYGRQVQSHHWQCKQIGTYSSTISTTTAATTTTTSSSTIHGCPPTSPLQSFLSDSCHGLLPHTLTASDMTIECANCAANQPGQQCPTPLGFWDLGFGASMSGTGWDLAKRLGNMCRDADSCLFMLCRTLFCLCPTAPSSLADVFALYAQVLRKWDSHDRVKHRGGSYTDASDFISHLNTDGIDSLFPLWTQLHGSYENPKLTSAIASLAGHDHKNHDALSSLFNDTTCLSPSGCAPYLQPLGLHARHTYPQKHAGLYITWIMYLAWQFWELLCELLQALDNIDCTASGCATCPCQPGTHGGKYACHCPSLVQCAGPLPTLYRYGFTYRNANLLVSDNRDIHCGDLNTQLKEALHSDYFTELFRQIDQLIWHIRMPFFYSLVALWSLVAVYILHTFLYRMDILRIRSHLLNTKASHLIDVKALLIPSRKMQSLYNASYFDDDPDELLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8B8</accession>
    <name>A0A061D8B8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="3 7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0308400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3 7 9"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769122.1">
        <property type="nucleotide sequence ID" value="XM_012913668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8B8"/>
    <dbReference type="STRING" id="5866.A0A061D8B8"/>
    <dbReference type="GeneID" id="24565477"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308400"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000001">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="130"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="298" mass="32905" checksum="A22D64D53FB61E60" modified="2014-09-03" version="1">MAKRLLTDFFSPLKGCAKRSRSSLDAVADTLTPETAATPEAPPKPDPVETTTATAKDPAPIATSAPAVEDSDANRGVVATVQAMLGDEWGSKLSDELSKPYFEKLWTKVANERKTKKVYPPENLVFNAFKLVPLSKVKVVIVGQDPYHQPRQAMGLAFSVPRGVAPPPSLRNIFKEIGSPSTHGDLTYWARQGVFMLNTVLTVVDSEPLSHSNYGWDAFTDRVIDVINKHREKVVFLLWGKSAQKKCDSISNTRHCVLKCGHPSPLSQKFFLGCDHFNKCNAYLTKTEQSPIDWKLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G4</accession>
    <name>A0A061D8G4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0103490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766221.1">
        <property type="nucleotide sequence ID" value="XM_012910767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8G4"/>
    <dbReference type="STRING" id="5866.A0A061D8G4"/>
    <dbReference type="GeneID" id="24562576"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103490"/>
    <dbReference type="OMA" id="VRMMENT"/>
    <dbReference type="OrthoDB" id="1840754at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596083" description="50S ribosomal protein L22" evidence="5">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR94035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25539" checksum="088CBFF0680448BB" modified="2014-09-03" version="1">MHYGILLCFIWIATRVDSFVMRDVDSTRLIALGALVRTSRAKKMEIVQEINSPFPRRNYKADGACERMVANSVLQWRKTMLDEAYRREFNWPYRKRHRGGRLDKLRLERRVQAVARWQPLSPIKVNKIFRHIRKLPVMVAMGDLAQRGANRYAVAVYKLIKSALTNAQTMYGSDDAPLVPRFRELTATNGGFIKRPLFRAKGRCDVIRKPKTHIKVVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8I2</accession>
    <name>A0A061D8I2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0307120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768994.1">
        <property type="nucleotide sequence ID" value="XM_012913540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8I2"/>
    <dbReference type="STRING" id="5866.A0A061D8I2"/>
    <dbReference type="GeneID" id="24565349"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307120"/>
    <dbReference type="OMA" id="NGPCINI"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="73"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="372" mass="40418" checksum="3E02CF9C1C496E07" modified="2014-09-03" version="1">MSGDRELPSNAKAYSSDVYRQIDPVGFYGEYIRRQVRPDGRKLRAFRTVGVSDLLEGTAGSGRPLGDGGTITASVRLTAGETHVHCTVRAVPGYSDVTIPLAPGGDNAVSVAVELPKQVQTYVYDANGNSANVHFCVSTLLETVLNCEEVVPTRQLRFAELLREEGAAAPDAVCEYLVRRRFGWKLELNILCEEYDGNLLDTSVLAASFALRKATLPVVLLDTADPANPYRLLALDQGILEQASCGDAKAVALLRSNRRAIEKQLSVQLSDESMLGQLLGSSAHLGRALQLLALPFTVTFLRFSDETFFVDPTSEEERLGTCVSVYCLRGADGSSRCQPLNLMCCPGVTPDVYRCLQQVATDLIDCIANTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8N1</accession>
    <name>A0A061D8N1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0307920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769074.1">
        <property type="nucleotide sequence ID" value="XM_012913620.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D8N1"/>
    <dbReference type="GeneID" id="24565429"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307920"/>
    <dbReference type="OMA" id="SYHINID"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1780"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="932"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="835"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1853" mass="203283" checksum="80F027933A851486" modified="2014-09-03" version="1">MASANKFYFRSLRDCLIFFYWLNTENKKHAEIAAQLHNRISNYYNNADKSKMQTALSTFVSNVNKFYKKLVKQEIPKQAVSSSNSIKSNANVIEIVDALLECLPKFLSAMYFLEYCINPNFSKLGGGGWEYDWPGAFSESYWYPNSGGDLDKYLYDRSGSDNGGIIPGGFGKVDRELRYYDYSAYPQGFNMAIDLTNIVKKQNDNFFRHVFSTSVLSQNYGVKIPNTANAIGLVGTFCDLVNAEKSTDGGDLIKTLNTDLQIKRPGKCINWGQLKQHCSKLKQFQINTLFTDKTFNHTGQSLPTSLLKTRDFATKTADWLRGNLEAVRTNLKNISTTLHVDDHRPTDGLGAYFTEHFFPYGFIFGFQHHEKWKMNAKTLLRNWNGVIDSLRDDDGGLHKLKKILDGDNCPQDKVKNPAPPTQPSAQRPRPRPRPRPRPRPRPEPALPEPAQVMPDNKHSGPLPQQPEASLESPTKSESANPVATKTEATQKGSTKADPPMPAATKTQATAPQVKNGDGTPNQGTAGKGAQNQGSSNNAPQNQNYGQNRKNAQSPPGKDSPSPPSGGAGAPGQAGPKGNQGPQGSSSTGSTKSPPKNNVKQQPPSQPQPAPPPPAPAPSAPAGPSSTSQPGGGGGSQNGGDGAGRKPGGSTSPGKSQSTSVQSPGSSSSSVVVTRSGQGPPAAGPQGGNGRGSQGSGKKGQKPVVTSQSVTTQPSSATNQVTQSTGSSGGKGLPGAGQSGGNGLGGQGSDSKGTQPVASKTPAPPQAPGVPPPGAPSSNVPVTSNGQGTGVQASTPGITQHGNQAPHAGINVSNTASTAANSSSSGTGGTPNAGHNSDEDEKKKQLDAYKAEHKKKCDDMEAALKRGRQRLAEKQQKQQKKLNADLQNWRRRQYYAPKDLNMNPRLAVQTGTPDLALDGVDVSHESSRDSYFAKRIEGLEHQFEEEQRKMERERKYRISRLENKQKLDENRAKALQEQHEQYVADTLRSLEQTKKDNAKRLSVALGFDGDVIKDDSVMKKQAHGINMQRIARQNILANRKLTDERIQKLVESAELNEYKDAVEYKNQQEHGKKKFYNDVFSGGDVFISHPKRDDSVGNFDFYLPQHIQTASDMPDHSFAESISRMSIPPVSLEITAPRNPADYNHNGMDTANATQNADLSLESGPIPTAGIGLDPFLDQFDDKFEIAKPPERNPNDPTNPDFTPTTLSFQFHNNHELSSANILPIPPKVLVERADRDTTQNENDPNYLDIQIHVPDRTIQDDSYHINIDPPFLPKLQPLDLIDPVTAAINLDIEPIDAPESLPNRYVDPYTHDAQSVSMCTAPWMTQAEIGDSTDIPDTELFPAEAPRTVRDMLQWLAGLRNPKHHSTLTECFNKAFGGSQSDPSQLALLVNGSYVRPNDVFDILQLTTMFAGSVLNSIAPNWKANVSSRIVKPNSSTISQEPDCCALLCQLRDYVYACHYQLEFLKSQCNRDKLSGGWKNDEYGSDITSLNSPLQAFLTDDWDSDFETHLFDPCNLCLKSRVRMGFRDEDLPKISKQGSVISTILTPSCGGDDPLLTLSSYLNCLTRRTPRTTGELVSFFHHFGNELHDYDQKALSSVGTALFTSHVDCPDWDRLGASDLQAVKGIRGSESLNQKSNSNHSNEHPRTLYTLVGCSSDPDNCHPRMSPITYRAYALYSQSFAHTYLSWTVYLPDRLWESLQKLHYDLQKHLGSGKCTSLYLCSTALPLLYTHGFTPPEGQSQSTVKCYDVMSILKEIVNGKPIASLMTAMDDFLYNIREPFIFTFVALWSTALLIFANTMLYRLDVLYIRSHLIRTKASHVIDVKALLTKGRKMLSLYKDVDYFDEDPIGQLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8U6</accession>
    <name>A0A061D8U6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0204520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767480.1">
        <property type="nucleotide sequence ID" value="XM_012912026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8U6"/>
    <dbReference type="STRING" id="5866.A0A061D8U6"/>
    <dbReference type="GeneID" id="24563835"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204520"/>
    <dbReference type="OMA" id="IHKRVIH"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000011">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="10">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="120" mass="13503" checksum="BB67122511D769EA" modified="2014-09-03" version="1">MEDVAAKDFKAHGDHDDSNRIHKIRVTLTSMNLKAIEKACKELINGAKEKDLRVMGPVRMPVRTLRITTRKSPVGEGTNTWDRFQARVYKRVISLHSSSEVVCQITSFPLDPGVDVEVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8W6</accession>
    <name>A0A061D8W6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0310540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769337.1">
        <property type="nucleotide sequence ID" value="XM_012913883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8W6"/>
    <dbReference type="STRING" id="5866.A0A061D8W6"/>
    <dbReference type="GeneID" id="24565692"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310540"/>
    <dbReference type="OrthoDB" id="365890at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="329" mass="36785" checksum="628100149FC7754C" modified="2014-09-03" version="1">MGFRMEDLPEKSQNGGTISSILSPSCAGDDPLLTLSSYLNCLTRRTPRTTGELVSYFHHFGMELHNYASKSLSPLGSSLSTPHPDCPDWDHLKNSDLQAVSGIRGSESLISKHNSSHDNDHPRTLSTLVGCGSDPDNCLPHCSPITYRAYALYSQTFSHTYLSWTVYLPDLLRESLEKLHYDLKKHAYAKCPSLHLCSTAPPLLYLHGFTPPEVGSQPKLTCSDIISKLKEIVNGGPIASLMTAMDNFLYGIREPFIFTLVALWSLAFLIFANTMVYRLDILHIRSHLIRTKASHRLDVKALLTKGRKMLSLYKDVDYFDEDPIGQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D914</accession>
    <name>A0A061D914_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone-like transcription factor (CBF/NF-Y) and archaeal histone domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0205370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767565.1">
        <property type="nucleotide sequence ID" value="XM_012912111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D914"/>
    <dbReference type="STRING" id="5866.A0A061D914"/>
    <dbReference type="GeneID" id="24563920"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205370"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="299" mass="33397" checksum="001B6D4AB95E8128" modified="2014-09-03" version="1">MADYADFEHRGEHIGWQVGQNEHFVLDGSCLVGDVGSTNKGFHLPVARIKKIMKEGEHPGMIASDAPILLAKACEMLIRDLTLQSWYCTLTTRRCTLQRQDVAAAIFKNSIYNFMLDVFKPEELYPKLEPKTDNMIQYDAVMNVNDGIGYSISPNVTKPRDSYVQSHGAIVQTHNAIYQRGSNRYIPNQAAQGQMVNAPISQFIPCHGMPAINTMIHYSKSVPSSGHVMQNGHVAKIPMQVIHSAKSHAIIPGTLTYAEGSLLSEHPTNQTSQGQMPYVQHRYTAPQENITPRSYQQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D925</accession>
    <name>A0A061D925_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769234.1">
        <property type="nucleotide sequence ID" value="XM_012913780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D925"/>
    <dbReference type="GeneID" id="24565589"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309510"/>
    <dbReference type="OMA" id="YASCRNE"/>
    <dbReference type="OrthoDB" id="364001at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="262" mass="28729" checksum="6BD57BB33794BA82" modified="2014-09-03" version="1">MPNTKTAVCPAGIMNKIGVPLDRIHPVAIVVGNPPWLDHLAHLATRHEVFSQYKSLRSMELEYNGQTFFALSYGYGATNLHRLLCELGLFGVRCVILVTDSVSLTPGRVPRKAFCVTYAACRGENTSTIEVDISYPAVAHPDAVRALRQSAKKMGIATRLTRSLTRDTVYPPRVDRGNSLRDEVLQTDVDLEDREVSTFLVACSIRGIVAGVISCNETEAHRFDTKTGTVVEDEDVIEARGKAMRIAMGAAAELSVDYAFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9B7</accession>
    <name>A0A061D9B7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0105990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766476.1">
        <property type="nucleotide sequence ID" value="XM_012911022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9B7"/>
    <dbReference type="STRING" id="5866.A0A061D9B7"/>
    <dbReference type="GeneID" id="24562831"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105990"/>
    <dbReference type="OMA" id="RIMSKEN"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="154"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="326" mass="36873" checksum="B6891495DAE7028C" modified="2014-09-03" version="1">MLPNSLLVHQVHQVLSELVRDTGMRVDMVDNIETQEMPDVVIGTPQKLLSKFDVYNLNFKVDVFQNIAYLVLDEADQLVEQTSEACLRRFLALANKRVKTILAAATVSTAGRRSTKNSIDRLFKNLTVRSTDRVHALPTNLEPNFVYCTGYEQKVEKLLEILGEMKPQQRALVFCGTVKSSEALYDILKKTHRHLDVGLINRCVDVETQLAVVDEQHGNKVIICTDLLARGIDIPRVSTVVQFDFPTNVLDYIHRSGRAGRNMQRCKASLLWTDADRDFFTLLSDNHDNLPALFSRKRGLRKRLKRGLPVGDTPARSGGEDLNDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9H8</accession>
    <name>A0A061D9H8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0106790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766556.1">
        <property type="nucleotide sequence ID" value="XM_012911102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9H8"/>
    <dbReference type="GeneID" id="24562911"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106790"/>
    <dbReference type="OMA" id="RCNLNRG"/>
    <dbReference type="OrthoDB" id="366081at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="335" mass="37447" checksum="94BC512143DE98F2" modified="2014-09-03" version="1">MLNQLAFNAEEYTKDTSHFLFLLTTIANSIRVAWKRRTKLPLKAVALETDIYEKAETDLRHQEGEKHYFPSPRSAVLFLIDRANALIKRSSSDEFVQIMLLNCVKSFKPDSRVKFELLNECKRRVNEISCGGIPQVLQTLFTLFSPNAPELVEALVLYLDRVLAEITLHNDPGVLQIEGSRLFEISFLQDVNILGNVLSIFDRCNLNRGDLATQVAEMMERSNFQQLDGASVQALIDLLHYIAFSVDRHEAIDVMAILLQQKLEGGAQVSSGQLAAIAECFVAAPMTLNPLRHQGLIQAIKQKANSSSGDAKALQAILKRIDWRRDAAGTPPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9K7</accession>
    <name>A0A061D9K7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769542.1">
        <property type="nucleotide sequence ID" value="XM_012914088.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D9K7"/>
    <dbReference type="GeneID" id="24565897"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312590"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312590"/>
    <dbReference type="OrthoDB" id="365890at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1228"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1297" mass="142332" checksum="9E13609302ACF89C" modified="2014-09-03" version="1">MVKITSRIPNLNNLKQCVKFLEWLKNNESVQSQVTAELVKRLALYYDSKTQNEESIKTALSSFLHEVSHFYEKLCKNAKPTNYMANTPNVVLYTLLACIPKLLSVVHFLWYNVDGKFKNAGGGDWANEPVGQLTSGVSKIDRYLIEMSFDKYGVIPGAFKKDEVRGAHENGYANGSVIASNIPKLLTHLHENFFSDVFVTSALTTAGAQPSNTANALALLKLFCEIVDADTNNEVQQALDGDFDKDGYCIEWRELKEHCSTLKISLENVFNAHVLSYTGHTPKAGDLNTEKFAKKMVRWLRDNLDKVGGSLKNIKTDRYTGASDYFTKHFFPYGFIFDDQNIGTEINASEVLKENWDRVIGEISRYGDGLDKMVKILKGIRCDPTHNHVKTADLEADDEEDEVVIEELDVSDDLGVEGTPNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGSSNQNNDQSEQNPESSQVLYGSSVPPEDGKNHGPAGSPGDAGKSAQGSGPPVQPPALPQGLGLNQPPGSSSPEASDTDSAPGAPGPKGDPGQTGPTGPVASASSQVPDGQGIQAPQSTDLSLSVPSPTPLASPGSPKLTAQTGVLGAESQDNASLGTQITGSPHAVRTQAANVSSPRSAASGSLDPGSGQATQDPPDVEVEIVMPSLIDNGGGYQPSGNGFRGNDIDGFEDPNAINLLKDSNNHRDTFGKADAESDISSYLAKLQETSKEWSNSLRLNDANQPLKPREFNAFPYYGVAGDLYSPQCRNPWYIHDLSTDPASAPPSSLPATDHLPSPKTVRDMLYWLVGFNQNGYIGYIRKYIKDLLDDINKDASKVSDTIEVSGNPTKLDASMVTQTLTEASLYAANILYTVKYRDYYTAYNDFKFESVYSQLYYSSDPACLLCQLRDYVYSCHHQLEFLKSKCSQDKSIGGWPNCYYGNDISSSNSLLQAFLTDAYDSKFKTHLFDPCNICCKSRVYMGFKHKDLPKPRQTGAILSSILTPSCGGSDPLLTLSSYLNCLTMRTPRTTGELVSYFHHFGNLMYDASSKGLSNLGSSLSKPHDHCPNWDRFKEPDILEVRELRGSESVSSNHDEDHPNTLSTLIGCGIKPLHCRRCFTPITHRAYTIYSPCFAHTYLSWTVYLTDRLWESLERLRCDLEGHASNKCPALHSCPDALPLLYTHGFTPLEGTPQTSLTCSEIITKLGAVVNGKPIATLMTCMDDFLYRVRMPFIYTLMALWSVAVLLLSYTILYRLDVLYLCSHFIRSKASHLIDVKALLTNSRKMLSLYDADYFDDDDPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9M7</accession>
    <name>A0A061D9M7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766616.1">
        <property type="nucleotide sequence ID" value="XM_012911162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9M7"/>
    <dbReference type="GeneID" id="24562971"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107354"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107354"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="281" mass="31145" checksum="CAA50F695B7BA484" modified="2014-09-03" version="1">MGIAIRWQELRWRSSLRSITNLLKYHTALVLSVILAKLCVTYASKAFYSSVYTESGLLAIYRPCAAALSSYLALLAMFMARQASFRASTKTGVYTEVLGLLNVVITILCIAVIANVVFRVYISGLYLVTVVCVAVLYQLRVRRQRLDVMRSLDKECIAAPHIRTFVTLSIFHVAASYAVAVVIGIVARVCATVWEYAHLAPTPDWNISGVLDTAMTVFPGIRAYTGNFYGVECVCILSAATWTIALTDAFYEYLNRQLSHMVGCASCAHRGAPARRRPQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U2</accession>
    <name>A0A061D9U2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769657.1">
        <property type="nucleotide sequence ID" value="XM_012914203.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D9U2"/>
    <dbReference type="GeneID" id="24566012"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313730"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1542" mass="171692" checksum="4E46ABA51A872F36" modified="2014-09-03" version="1">MAAINLNTLKECLQFLEWLKGRKWADLRTRLAGRLARLLDKKYEGVDHKQIESSLSIFLGHVSTFHHKLCNRAGQSNINRFTAKDALEALLQCIPKLLSVIYFLQYHVDKRFSKVGGGDWEGEQVGRIAWFSTYGPDFVKRMKSSAGPIDKYLIESSGSEYGVIPGGFDASDLKQLGHGGYSEGRLMTKDLVNIFDKDVNRNNLFRDVFVTSAVSKNPSVEKANIANALRLVEDFCGIFKNSKNAEDFKSHLESRGSCINWDDLKQHCSTLKDKFSKLFTNNRFSFTGYGRTYEFLDKSMDKKMAKWLKNNLNAMRNQLGGVGGRLDVKTFVDTYLIPYGFTFNGYKVGTGRDNYQALKKDWDAVIGELKKDNGGLQKLKQLLDGTLCPNRKKDKQPKTDSEPKPGPELIDEDDDEDEDEDEEEPWDDNLVYEDTGLEAENAAPIKPKAEAPPAKVPEIKKSDGTPNQGKKVEGAQNQGKKAEGAQNQGKKAEGDTSQNGQSEAKSPSSRVSQVVQTQPSSNSSADSEPPGAPGPGSGQGPGDQAATSGASQQSGREGQTSSGGDAISSTNDGVGGGGMDGWKAGIGVHAPPDQKITQTCPLGLTQKVENGKTHCYPPNHKRITPNYEFNYTADQLWNNYIKREYSPKSPTNLQTKHYSIGGSQPSHTAPAPSGQNTGGRNGHRRDYYEPEWRHRQQGSDLPPSVPLLAPLDGHPVIESTPDPNEKDREDKFLKATQDILGDHITRKEKWDEKQQQDNEKIKQDREAAENKYKSEARTQEIIQRIQERNEKRKQTAQDLDKRYEKTREEIWEIQKQKNLAYIETGADEDTQTRLQQERSEQNKTSEQQNISAYPPTFTPSTIPRQPSRPAPAPSGQNTGGRNSNGRGYYELGEWRPRHEVSSATNMLPSDFIAFAIPDTSSKRLEKEKQKRAESDKQRLKLRRQTEEKKFSDKQQEAWMKEAVELEKADDRLKQGLRDHLLTGGQLKNPNADFVLVSGAPIEPPQSVLLEGMVLKDNSNPTAKWQHDAYKQYFARYPEVMGTIIPAPMTERAPHLSPLDAMPTGNPIIHPKSSSASAFRNTQADKPSMTPNRMHPTGIAARQNKHSVLAYAPLSPTTESIDDLSTARFLSVSGRSLTKSSKADAKAPVLQEIDPPVPQSMFVGSPVPDAELPSSPIPRATFLTEPQPTMGFQIEFPKRTVRKVEPEIGLSIEVAHHGDRTFNDVDLDDPYANTADILKDELKPSDDKVSSGLPKNNFDLDFAPERIGLEGYDDPGMPRDTPRKADERVINPFSTNECLNPWSVDTSTTDIITPPASPPPLTDHLPPPRTVREMLYWLVGFNQLGYIGVITENVNSLFKDLKSDAIEVTGDPITLTASMVTTKLTEACLYSATVIYKIKHNNDFEAFATFDFKSVYSQFRYSTDPAGLLCQLRDYVYACHHQLGFLKSQCSRNELHGGWQDCKYGSDITASNSPLQAFLTDDWDSTFETHPFDPCNLCLNSRVRMGFRDEDLPSSQQTGNTLSSILTPSCGGEGHDALLGTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9U9</accession>
    <name>A0A061D9U9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CPW-WPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766701.1">
        <property type="nucleotide sequence ID" value="XM_012911247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9U9"/>
    <dbReference type="GeneID" id="24563056"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108130"/>
    <dbReference type="OrthoDB" id="365677at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006387">
        <property type="entry name" value="CPW_WPC_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01492">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09717">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01099">
        <property type="entry name" value="CPW_WPC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPW-WPC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CPW-WPC" evidence="1">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="225" mass="25602" checksum="7859FDFB07AD73B9" modified="2014-09-03" version="1">MIALRAFRRNDIVERWTESPLYSRVCEAPISYFGPCATLLPSLESRDDKERMEKECRINWPCYNQCEQAYDAKCPKFWQHENGLCMPTPAYHGPCAYLIDLSKLQTTERVLWSNRCGVTWPCKPASNDKQTEKMQCKLQRAVPRGMDGSTSVRNTFQRQSAIAHRQGAMRSTGIVQRPVLPNRGFVVLQRRNEGGSASYTNGVTTPAGTVRDAVRCRIPMCSQMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9V3</accession>
    <name>A0A061D9V3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0108180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766706.1">
        <property type="nucleotide sequence ID" value="XM_012911252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9V3"/>
    <dbReference type="STRING" id="5866.A0A061D9V3"/>
    <dbReference type="GeneID" id="24563061"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108180"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="12">
        <location>
            <begin position="41"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="11">
        <location>
            <begin position="310"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="436" mass="46529" checksum="39528DB4161EA3A9" modified="2014-09-03" version="1">MSNISCRGFSITRSMAGGRLAPKGSFATCYQCRDSKRFLNVSEFGGMKLLKERGIPTPMNLLARSPVEAESITREILSNTKCGQVVMKAQVLTGGRGKGKFVGTEISGVELVQSPDLAKVTAEKMIGNILVTKQTGKSGLKCKEVIVAEKLNLAKERYISFMLDRKSSTIMAIATKHGGGNVEEVSEKDPSAVLTIGINPLKGISDVEVGKIADHLDFSESLKEETKKVVKGLYDTFVKNDALLLEINPISETNDQKLVACDSKIIIDDNADFRQKDIFASVAPPENELEARALEAGLNYIPLGGNVACIVNGAGLAMATLDLLTHHGGTPANFLDVGGSATSDMLGQALDIVASDSNAKVLLVNIVGGIVHCDKFATSFVEATKKSKMQIPVVMRLQGTKSDVAKKILHEAQIPHIFCSDFDSAAKSAVEIANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Z5</accession>
    <name>A0A061D9Z5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ataxin-2 N-terminal region domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0312310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769514.1">
        <property type="nucleotide sequence ID" value="XM_012914060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Z5"/>
    <dbReference type="STRING" id="5866.A0A061D9Z5"/>
    <dbReference type="GeneID" id="24565869"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312310"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312310"/>
    <dbReference type="OMA" id="HPRLYNG"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="200"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="644" mass="69581" checksum="9F02A1BE964496BF" modified="2014-09-03" version="1">MMRNSGSGHPHGHAGNTHKGDKRASTLARVNEERLAYAISCLVGKDVVVHMNGGRIMKGTFHSCDPVPRPTKAYDIALRHARAVQNKSEDSGSGRQYVVFGTDYQYVVASGVSMGPSAKESKSANAASAPPAGEGGASNKRSGSGKFKTDTEISGSKGQRHSDKLVEWASEAPVADNQLYVLEAQRKTEWDQFESNRKDFGVESTYDESLYTTELNMDDVPQRIQDQATRLASEILGSSGEGGYSQLESYLEQDEDAVNNAVTEQIVKKALARNSREERREEKREEKREDRREDKREEKYSQGNKGKTRSSGGDGAAGGHNSRPASSSRVMSYKDIIANSSTSPSQSQKGAATQDNTPQQGGHGKGAGHERDSAQHTVRFRDAFPATVFQQTSTARSDVNRGRAANVEARGGEHGAEESRKGERGGASHPQKAEERAAAKPAVETKPASPASQTSGTIKKTFTFNPNASSFTPFSAAHIAVRLASPSRRSGSRSPMRQAQGPQKAGYPVLDVSAYTVLTWPLTDYGLEDGWQNCSDVTYRSVIGDLSQYYAAPGIVAMRPQHPMVASAGMTTVLLPQAGPVTYPAYQLGGIPVNMVPYNRQVTPKFFARQAQQPMQPIVPARRPMNGATTPSIGHAQPQVKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA07</accession>
    <name>A0A061DA07_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766766.1">
        <property type="nucleotide sequence ID" value="XM_012911312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA07"/>
    <dbReference type="GeneID" id="24563121"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108780"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600731" evidence="1">
        <location>
            <begin position="27"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="174" mass="20036" checksum="A2FC42E5935269FD" modified="2014-09-03" version="1">MDYIFFAGATWLSLFALLRTAKVAEAGSNYTYPTRKSEAFVQQPGPVRLLPEDVARIHAIMDELQAYAKDIKYDQGIIIEALQYIIAGVRECVNSSGQTHDSIFLAIDSYLNLILMPPIRDRYPKFLPMDAYVNILRRRAEMRIRSLRTRIYDIWLDYVLRRTGAATQLTDRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA14</accession>
    <name>A0A061DA14_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767935.1">
        <property type="nucleotide sequence ID" value="XM_012912481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA14"/>
    <dbReference type="GeneID" id="24564290"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209030"/>
    <dbReference type="OMA" id="CYPAYHF"/>
    <dbReference type="OrthoDB" id="365791at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="639" mass="70098" checksum="B6CF5A381A8D5FCF" modified="2014-09-03" version="1">METGPVCAVSGAPNVGGTSGKDKSIPAIDLINAAVATDWKRLERVAAPTGRSAKKARNVMADMASVFSSNLWAYIQPNTDVPANCASGPGSRTAGDQGSSPASNTRSRERSCKASRASGNASNHMAMKNAAGAPVGMGLDRLFGKSNSKSHLFNFGDATSSLGLKSSLDGALLSEDRSGVDSQYTTTTLEDFERLSPCYAESVGTDFPSDVEDLKPTMADSAPPNSLHSPMNALRQKCEQFFEHHGLVVKVRKLPAEGSVRRRVNGNADCNAKEELCYPAYHFISRQRAHMVEQLMRSRSFLNTRYNNSSEMRNALSPFPLIELRDGTVKHLESLRDDLCDPEFTGIFVSVSTKAFVSESEFGRVRRTKTVAWALIELLTSNERCLRSLWVHSAISAPATTALLSALLPYSMVASMVASPGAIDERYPVKTFCAWLSDFDAFPRQAMVLLTSPERFGLIKHHDAPDAARDAAGGSRGNAHHFASNLSHIDAGVSGDQCYCYHGANWNDVNHVIVSCTEQLMYSALPQWVKLVPERTLPDLLDDLERIVLPDAVSYNQSKDKESPAAIRDAEYAGLSPLQIRDVLMYLYGNRWKSRVKPGALKPIKEQHFLPKPCFQQPIPMLDEREERRKRRAQLVSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA37</accession>
    <name>A0A061DA37_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plectin/S10 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0312960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769579.1">
        <property type="nucleotide sequence ID" value="XM_012914125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA37"/>
    <dbReference type="STRING" id="5866.A0A061DA37"/>
    <dbReference type="GeneID" id="24565934"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312960"/>
    <dbReference type="OMA" id="NWQHLYF"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="114" mass="13167" checksum="C4304D2DAC3560DB" modified="2014-09-03" version="1">MTVAGMKYSLIPRENLVLIYQYLINEGVLVCQKSSKIPMHPEINVPNLHVMMTMKSLKSRNYVVEHFNWQHLYFILTDQGVEYLRTFLYLPPTVFPATHSKKPATKAAIKEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA46</accession>
    <name>A0A061DA46_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0400830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769777.1">
        <property type="nucleotide sequence ID" value="XM_012914323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA46"/>
    <dbReference type="GeneID" id="24566132"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400830"/>
    <dbReference type="OMA" id="RFKREGC"/>
    <dbReference type="OrthoDB" id="413777at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="17790" checksum="0908032AB2C35054" modified="2014-09-03" version="1">MAYRFLREGLYTRRKSLRRNGFTPFVEDLMWTATDWHYQHYISRAARASLLTHQEGNRVFAVNNASTEVNRVVEHFKASRGGTLAKGTEFPFFRLATPNIVPYRRQSNPFCQRSSNRVGWQLHHRQLERTPRPYRSTKLGGTDLSVPVMPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA83</accession>
    <name>A0A061DA83_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0313550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769639.1">
        <property type="nucleotide sequence ID" value="XM_012914185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA83"/>
    <dbReference type="GeneID" id="24565994"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313550"/>
    <dbReference type="OrthoDB" id="366442at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="192" mass="20788" checksum="4BF0FCC7E6271266" modified="2014-09-03" version="1">MNYGGKACFLLFTVAWLGVTANAVWYCVTLKWAFDAPADCFGRGLDSFGKCLPFPRPAKPAKGTIPSPGGLGTDTYKGLEQKPAKAKPLEGQESVTKNVKEEKTLHPVPLPEKEKLPEGGGGESHDQGHEGKIEATHVIPDPLEKTLESPEAVPKVIPEPAVKKPAQGKQKKKKEKTPRRSVRPDGLGDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAC1</accession>
    <name>A0A061DAC1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0308260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769108.1">
        <property type="nucleotide sequence ID" value="XM_012913654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAC1"/>
    <dbReference type="STRING" id="5866.A0A061DAC1"/>
    <dbReference type="GeneID" id="24565463"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308260"/>
    <dbReference type="OMA" id="TVQMSEN"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="301" mass="34630" checksum="C383C526EBE263AF" modified="2014-09-03" version="1">MELDVDSIIERLLEVQGNRPLRTVQLSEEEIRGLCLKSREIFLSESVLLELEAPIKICGDIHGQYYDLLRLFEYGGFPPSSNYLFLGDYVDRGKQSLETICLLLSYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYSVKLWKVFTDCFNCLPVAAIIDDKIFCMHGGLSPELNSMDQIRQIARPTDVPDTGLLCDLLWSDPDPNTMGWGENDRGVSFTFGSDIVVNFLMKHELDLICRAHQVVEDGYEFFSKRRLVTLFSAPNYCGEFDNAGAMMSVDKTLMCSFQILKPVDRKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP0</accession>
    <name>A0A061DAP0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0211210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768160.1">
        <property type="nucleotide sequence ID" value="XM_012912706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP0"/>
    <dbReference type="GeneID" id="24564515"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211210"/>
    <dbReference type="OMA" id="TDVRIHV"/>
    <dbReference type="OrthoDB" id="366185at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="190"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="691" mass="75348" checksum="3A9DD3B0F8213E31" modified="2014-09-03" version="1">MSDNAYRRNVNRGDSSPQSGYDEDYYRSQSARGQKSSARSQGSPTISFKTIKNTSLSCAKSLTNKMIAMTSSGIQAASTAINNYKETAAANARKAALANPYSFLRIAERISTTNDPVASHRELVAVMEHLLIWQNPPIQLNLERDRFGQPTTESMRSIRLINEFLLGKVLTYVQGRRDCCLFIIKFATWRMRTTHIAEEILLSLELLQRCMESYGSFFLSLMTRSCMRRLRKLLRMNKITTSLAGGVKKQITKFLVGSSNVHPGVPTDVRIHVIKAKVLYMVQLWHDVFMLDQGLFPVFFQGYRDMRERGIKFPQIEVCERNKINLCPVMRRSKFHLTGGVTLPLSPQELDSILATVNSLNTLPPGCEHAAALKRLKDSKEKIVASINILAENRAQITDPHNYEEVMRKMLMLNDCVGMHLLVGGTGKSSSTQLLSALEQLRGATTEEPTPQAAPPTPAAKEETKANLLDLESSSDSENEAFDSFFDDKSGGAAKKSDDDYDKFFADFGVFSHSTATSSANRGQPAEGAPADRPKDYFSDLGALNFGQAAETKPASGVPATAGPFAGANTASVSAPSGSSAAVTPRVPAEAGAFSNTTFPDIDLSALDLVARPVSPQPTAELAESSAPASPAISAAPSSAPGSERDSEDEAEEPEEKKESPTEDGKKSLTELMKELDEIDQDFGHMSVSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAR5</accession>
    <name>A0A061DAR5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0211530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768195.1">
        <property type="nucleotide sequence ID" value="XM_012912741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAR5"/>
    <dbReference type="GeneID" id="24564550"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211530"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="128" mass="13956" checksum="9DE16F0D4BEB225D" modified="2014-09-03" version="1">MFGSISSSSLMNLRIFSLGRLQTRECAVEAQALNGPRKPISAHLEVVRYSFGSVSPRKWAANSSIRSSAATSASSGRTMVSSKRRIDSMVSGTCFSEGSRLRTRFLRGARSGASTILRARRSRFFCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB14</accession>
    <name>A0A061DB14_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCO1/SenC family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769363.1">
        <property type="nucleotide sequence ID" value="XM_012913909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB14"/>
    <dbReference type="STRING" id="5866.A0A061DB14"/>
    <dbReference type="GeneID" id="24565718"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310800"/>
    <dbReference type="OMA" id="GMMYAIA"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="239" mass="26883" checksum="63824C95FC09D5A5" modified="2014-09-03" version="1">MIIANVQRRLLAAVARPNGRAFSSLRGTPQSRGIFKNVTRSAVVCGCAAVGVYALFDAKRSRQRAIVQEERYGKPQLGGPFTLTDQTGKERSLSDFRGKLVLLYFDPGDGDSRLDIKDAESLNALAEKRFGNVVQPLFITVDPKRDSVEKLAEYAKEYHPRLVALTGTHESIRDVAKKFRVYYNQGITATEQDYMIDHSIIHYLLDENGEFLEFYGKNANVKEIADDIAKIVQKRKLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBE6</accession>
    <name>A0A061DBE6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0202220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767251.1">
        <property type="nucleotide sequence ID" value="XM_012911797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBE6"/>
    <dbReference type="STRING" id="5866.A0A061DBE6"/>
    <dbReference type="GeneID" id="24563606"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202220"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="3">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="276" mass="30826" checksum="64608C8DEF65C787" modified="2014-09-03" version="1">MVRSNNVGYDRHITIFSPDGKLYQLEYALRAVKCSNLTGLAVKDDNAIAVVSQKKLSAQQGNQDVLLDQSSVTHLYHITDEVMALLIGFPGDCMSILYKSREIALEYQYKYGCNIPARVLCEKLADINQVYTQHAYMRLRACTGLIMAIDEENGPVIYKFDASGWFSGYKACSVGAKDQEGENALERILKQRETVTLKEKVKSDLEVDTESHHLTGGAETRVTVEAIKAMIAIDAYDQLNGAKSIEVAICTRDNPVFRQLSEQEIETYLTHIAESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBQ3</accession>
    <name>A0A061DBQ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767366.1">
        <property type="nucleotide sequence ID" value="XM_012911912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBQ3"/>
    <dbReference type="GeneID" id="24563721"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203370"/>
    <dbReference type="OrthoDB" id="366586at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="163" mass="18479" checksum="2EC4421D76D51B77" modified="2014-09-03" version="1">MSLLTRFSGLIGAGIKAAQKTFASAAKRGIESLTDSAFDGAIDASSIKSALESPGVEQLMDSVIQMVMWHVWISYVIPMMLIMGFLFGLLFAAYFYGWLNRCSAGFLRCITLFIEMIMYAYWRLKKALRAFWGAYTEFDDYGLLSKFRGHRYLPAKFAKCKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW1</accession>
    <name>A0A061DBW1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767426.1">
        <property type="nucleotide sequence ID" value="XM_012911972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBW1"/>
    <dbReference type="GeneID" id="24563781"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203980"/>
    <dbReference type="OMA" id="NGEGNWI"/>
    <dbReference type="OrthoDB" id="364500at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="557" mass="63301" checksum="F792442E049D5E2C" modified="2014-09-03" version="1">MSRAEASLASGSGFDEELSRFLSASHGESFVELLRKKCAIGKTISESFTCSDADAFTFAQSLSYRKPWQIAVDEFEIKLRRCGDRRSANLYCIFHQQLCKDWQVRECILDRSFRIFEILPHRKTLLHLSEPKTTCLVLLSFCFGLDNVIFVGLHNVPHSSCLPGPYLGLLHPGSRESFLDAICHLEKLHRDKSPSAGGDSEDARLECNGRLAEISYLASEFDDLFAYVLCEPECYSAFTEPLLRRMYTNRFYGRVALWLLMRGYRERHREQPLGSILKRFNDLLRIVCRILNDVYHSRGDRAASENRNFGTMAVITLIYSYLYGILSIPVRLTPWNKTVKGETCTCKYAASSHETDPVDQVNEVDSSHSSTVTSPTAKNDVSAGLPSQHNVGLIGVDFASAAADAACVESTRRRDVIMSHAIGLLGDDGNWLRRSERYVDVIDNYKLSLCWYRRPLFSNCFQTNLKVLCPWAMMYHQACVAPCSYAWLEWQGKSIESWSSLPLWRNVAPAKGKTEQSGGDCLRCLKRLVCLRVRDCVSFIFDIEADIKRTTRRHYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBZ6</accession>
    <name>A0A061DBZ6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769698.1">
        <property type="nucleotide sequence ID" value="XM_012914244.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DBZ6"/>
    <dbReference type="GeneID" id="24566053"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400080"/>
    <dbReference type="OMA" id="QEDWMQA"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1971"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2046" mass="221303" checksum="8BBE32016205AE88" modified="2014-09-03" version="1">MAKTHGFLFSSLKDCFVFFSWLHEGDGKVYLEPVISYLHQRVSKYYNWIDSISIKVELSNFLGHVTRFYGKLVFTVTKDAASIPGDKKMKSAEHIVNALLECLPKFLAAMYYLWYNVDVTFRGVGGGGWAENWLGYGGGLDTYLTKPYRSASGGIIPGGFELRELRYGWVYANYTQGKKMTTDLRWILDKKVEQNYFRDVLALSTIIDSGTESVNTANALAVVNLFCEIVAEEAKKKESGNLRKKLDEMVKPKCLNWTELQLVCSAIKTSYANMFTHGPFDITGEATKASYLKSEDFAVHFARWYKEKFERILQHVGKMHSFVTESASFNNRSLVTTVFYPNGIVYKGNNVVQANGFLEHWEWTNALESFVDDNRGLRKLKELLDGTDQGICSPPAPTPELRPTPALAPRLARPAPPPKPTNTSTVNSSGAQGSRGVVANSHTTHGSRPASGVGGGRGGRGGTSHSRSGAQRRGTEPQPVAQKRADSPPRVQASPAQRTTQSQPKSAPQNAANSDSQRVADIQYTGGVKGLPAPSVSVPQNHATSSTITVQKPDIPSLSAQAKADHSSSAIAATTPRPSGSNSDSGNHVSVDQMRGLQPHGQPESVSSVLNPQNGQPLQPDKDAADTHHATDRAASDGSNGIGVNVQAGEIGSPGGSDSTGSSTSPLHPPPPAQPQPLPASHDVTAVPEAPKEVVPETKVPVMPPKKPEVPPNTAPIMSESPMAVATKTEATKTEASKPVVAKAEYDESVNKTNDQNRDTFIGPAVAKDVAPSPRSDSAEAGPTGSPVVHSTPSPTLTDSTVSCISSEPNTVQNHTLIPSTADTSHSRPTTPTGDAVAPGSPSRSIRQGVGLNDDAHSGKQLVSSPRSEPSQSSNGQAQLQGHTEPSTSIPAPVPPSTSGDADQSSQGGASSSQQLAVSQPSAQPHLTAQSAGPEPSAASSPGNDQGDLRQSQQSGISNALESDTVTTITSPDRSSVDGDGGASGSGGNARGGADGGSQFGFNSTQPHAQLPNPSDANPAATTSVGSGPPVSPDLTPISSPQENSHDQGAYESAKSTATVSQNDASDIAGRAGAAGTPVQQTVDNEGNGSQGQPSVAVPDPPAAHSSPIGPTDTDGTPGDGIAGSPGSASPGLQPVASQASAQHPSVQSPDSGSSGSRASSSGNGQHGRAASPNPHQTEDQEPQAGRDNVSTLISTDTPSGNITIRDNLGVVESAEMGKLWAYNWDYRADMKQKWKQFKEENKWIRNQEKAHRIQREGLQNYYSHLQPHMSHYEPVIGIPVPDWRDFDVDGEVVKNDNDPELQKKNFMEASHERLSIARHANAQRDRENLRQAMTKSAQLGKAAQKWQRDHQMLSTLLTGKATPNAKGLSGNTSPTEFPHIGVAVGYPIKPPKLPKRISKFIAPKNPNKTGTLTQKRTESLIHNQKLKIPWVPPPPMKSPSAPPPQPIIDFDVEQVYKSKNVFKSDTLKTTYIPVELIDPALPLDYYPGPPQHVQLPQDSNPDVDKMPALDFCVPLWTSQTPNDDFDDIPEIELFPAEAPRTIRDMLRWIVGIRRPKHLEVLEKCINDALGKVPDGVPGNPTLCVSNTKLKSEDVIKALKLASIFSSSVLSAIEPDWKQKSSRSGTVKRKDTDHDQDPDGCALLCCLQDYVYACYHQLAFLRSQCAGDKFRGGWMGCQFGRDVTADSPLQAFLTDAYYSRFKTHLFDPCDVCLKSRIRMGFRKGDFSKSAKDGSYIYYLLSPSCSGDDDPLMTLSSYLNCLTRRTPRTTGELVSFFQHFGSEMRKDVIGILSDMGKALSTPHPNCPEWDHLRRHDLDAVRGIRVSESPVSKHDNDHAGTLSTLVGCDMTNVQCTKLLSPITHRAYAMYSPCFVHTYLSWAVYLADTLRESLDRLRYDFTRHNVSKCGSIHHCHDALPYLYFHGFTPPEGTPSSSLTCSQVITKLKEVVNGGPIAKLINCMDDFLYRVRWPFIYTVITLWSTAFLLFAHTALYRLDVLRIQSHFMRSRGSHVIDVKALLTEGTKMPSLYDIDYFDDEALAHAWNRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC13</accession>
    <name>A0A061DC13_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0303530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768635.1">
        <property type="nucleotide sequence ID" value="XM_012913181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC13"/>
    <dbReference type="GeneID" id="24564990"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303530"/>
    <dbReference type="OrthoDB" id="365731at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="152" mass="17220" checksum="CE2B5CFC317DB213" modified="2014-09-03" version="1">MDQQEFRSASKDIWGIDANKLDMSSPGYESHTGSSFPTSEHTQQNSVMQKWRVDIQAAIEAKKQKEAEVMEAATKKAQRDLEEWRRVRKEKVESAAQNTKDTSGAELHKSVNGPFDWKKTAEILRKVGYTVNDQNSGSSQKMADLIFLKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC31</accession>
    <name>A0A061DC31_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0303880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768670.1">
        <property type="nucleotide sequence ID" value="XM_012913216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC31"/>
    <dbReference type="STRING" id="5866.A0A061DC31"/>
    <dbReference type="GeneID" id="24565025"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303880"/>
    <dbReference type="OMA" id="CFVPRGV"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="407" mass="45002" checksum="E8A00DB6B0E22037" modified="2014-09-03" version="1">MNVISCLKWLPKSYTYTDFFQSYIHRAEEDASDIDVDQEGEDQRDEITDEFDLDNYDADEVPGNSAICIITPINVQTGEQFFTLSNEDEKLIVEDAEDVESRKLDGDDRVIVCGNSGEDCASIDFFIYNTAYCGLETCHSILIASFPLVLEIVPNLPNYAPLVAAGTYESHIDIWDMRQIDKLDPVITLGGQGESQNQGHQDAVQCLSNSPHVSQLMASGSADNTVKVWDLNEAQVLHSFIHHTSNVQVVQFSPFDASLLLTASFDKTAALCDIRECKSNTSLKLDSDVESAIWKGANNIVVSMEDGSVAEYDIRSEKMLWQIKAHKKACSSVQLVDNVMVTCGLDSKAKVYKLGGTKPTKLASKNLNAGPLFSVEGSPDDKHLMGFGGELLVLWDLETIDRFNDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC76</accession>
    <name>A0A061DC76_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0401340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769828.1">
        <property type="nucleotide sequence ID" value="XM_012914374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC76"/>
    <dbReference type="STRING" id="5866.A0A061DC76"/>
    <dbReference type="GeneID" id="24566183"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401340"/>
    <dbReference type="OMA" id="FCPFAIR"/>
    <dbReference type="OrthoDB" id="1166527at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="123" mass="13714" checksum="C283FEC69FFAF447" modified="2014-09-03" version="1">MSGKVPSSKSQAAKKTAGKSLGIRYRRKKRIESFSLYIYKVLKQVHPETGVSKKSMSIMNSFINDIFDRMALEATRLIRYNKKSTLSSREIQTAVRLLLPGELSKHAVSEGTKAVTKYTTSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCH3</accession>
    <name>A0A061DCH3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0306130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768895.1">
        <property type="nucleotide sequence ID" value="XM_012913441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCH3"/>
    <dbReference type="STRING" id="5866.A0A061DCH3"/>
    <dbReference type="GeneID" id="24565250"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306130"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306130"/>
    <dbReference type="OMA" id="HQNDEIS"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="251"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="512" mass="57124" checksum="0491C0552FFB2CDA" modified="2014-09-03" version="1">MCTKEDNILQILRAIDSALPAGGPADAAVSTLSLGPGAEHPKVINAAKSLMAKGYVTLEECRSRRYSLSAEGKLYAAEGSPEFRLLERVRASTEPITIAEASAGIPSAEHGLKKALRASMLRVTAGQQLSLGAAGNSTAEDVTKKLLQLIESHGSDEQAMLEALKAVLTDEKKLRSELDDLKKRKLMDSQVEVSYLVRKTDKFQCQITQQITDLTQELLQERKSWSASDMKPYNFFSSGKRISRGALHPLTRTMREFREIFTSMGFEELDTANYVESSFLCFDALYIPQQHPARDSQDTFFTKAPELANLEGVGQEYIDAVAEAHGDGSRYGSTGWQYDWKLDESRKLVLRTHTTACTARLLKGMAEQFDHIKHTLPRKFFSIDRVFRNESMDATHLCEFNQVEGVMIGFGLGLGHLMGVLSAFYSAIGIEELRYKPAYNPYTEPSMEIYGYHPDLKKWVEIGNSGIFRPEMLLPMGLPEGVSVVGWGLSLERPTMIRHNIRNIRDLVGCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCI2</accession>
    <name>A0A061DCI2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear nucleic acid-binding protein C1D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0402800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769978.1">
        <property type="nucleotide sequence ID" value="XM_012914524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCI2"/>
    <dbReference type="GeneID" id="24566333"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402800"/>
    <dbReference type="OMA" id="SINIHYY"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="122" mass="13913" checksum="0440750D4ED0818F" modified="2014-09-03" version="1">MLDSTLSTIESKVDECRDLLEQLVESVIGSDIHDELTGLEYSKVFATIAFTFCSLRYVQEKLNGHNPANHPVSRDLVRVKEYMQEINDIMLRALIVNREAPEDKSDGSAQDRSLYNTAFCIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ7</accession>
    <name>A0A061DCJ7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770003.1">
        <property type="nucleotide sequence ID" value="XM_012914549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ7"/>
    <dbReference type="GeneID" id="24566358"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403050"/>
    <dbReference type="OMA" id="YMAFVNI"/>
    <dbReference type="OrthoDB" id="366261at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26324" checksum="DE3E564E6454BCBB" modified="2014-09-03" version="1">MAEENLLYTGLINLSTEHVLACYPRSAARGTGLIVEEGLEHVYEDATTKEPGTDLQEIQLENITIYYQTDDEDKLAVLVMVNAEDYPERLVQNMIQEIWRTVRLLVDQKGTVDFKSRTVQLPLSAQLARTFKRYNMEFETDKVLKAQAKVQGATEAVQESIQKIIDNCANMQQLKEMSQTLKTKAIVVKQYRCLFAERKRICVQYISFGVIIVIVVALYIALPIVLSESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ2</accession>
    <name>A0A061DCQ2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0307180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769000.1">
        <property type="nucleotide sequence ID" value="XM_012913546.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCQ2"/>
    <dbReference type="GeneID" id="24565355"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307180"/>
    <dbReference type="OrthoDB" id="10533047at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1593" mass="176873" checksum="3755294A1D5BB8C5" modified="2014-09-03" version="1">MAKIQLDSLKQCLQFLEWLRGEGRGMRGMRSNVALELIERKSHYYNWVSYTGDLPHAVSKFLDDVSKFYNRLCFKADGGSYDKPSRDDVFNALLECVPKLLTAMYFLLYNVDASFSKLGGGGWRENWPGYETSWWFHGSSGGPLQEYLRAPVDDPKYGKTRDTLPGGFEYGEIRYGRYSNGYIQGYFMTEDLKKILNKENYNDFRDIFLTTVISMAGTQTPNTANAVGLVGMFCDIVIKDNTQDGGELKRKLEDNLIDSYDKKCIHWQELKSQCKKLKDDLNQLINDDGFSYTGQAPPVTSISQTEFARKTAEWLKEQLSAVRTNVTTISSDYPDIHRSDFSPIYDFAVDNIFPYGFTFGAKNFGTFFHGLNVVPQKWKRVLGMLKSNDGLEKLRTLLEGEACPKFDAVKHIHTSTEANKTEVGTLTDTKTHDTKTEGKRAEGAQNRGEKEEGTPNPRNGKNTDAFAGSSVGNSDPRRPSNSEGIQDTAETGDTMAPGNAQSAHLPDQQTVQSSTHGSPPTLPGYPSSDSPPNVTHTVVVGKSRDEAQGSMFDALAANLPISISNVVFPQTPSASDPIPAPSGGHEYGAQASADRSPKGGKASQTPEDLTSTLSPAPLRARPRDRMDRTSTWGNSRFGGRRAQVTVSYESRHPPEVDRSATTQGTDAATTSTVSSPCPGGARDDGGVGDSGQEGSCSAGVQDLPKAQDGSSPHKCSGKWVDGWRVGQKVCLSHEDYKRALHIAEIWERAKKTEADQQKKQREEEDKFERMRALRQHYRQQDQLYDHILAVEGYAGAPPLSGKALPAPPDPVLQKQQEEGDKFQMYLQQRNILHGSDIKPFKKKPFAGPLLRPPKRSRPPPPALHNPKTTVATSDVYGIVVPNIPKTKPNVIDTTPHVENLDDYPVAFLQHVAGADLKNFSIKDVKASGSEEITQTLPPMPDFNGTPIFDPNLSSSPNPTAILLPSPPHPIVRLQAVIPGRPSSKIYHPRIDLSIQTVHHEDRTVDDIGTDDPQPPPELQPLDPIGPYTPAISLNLETPEPLPELPNNSAADYTHNASTVEMCLAPWTTQTPTHGSTDIPETELFLAEAPRTVRDMLQWLAGLKNEKHHETLEKCINKAFSGPHSDPSQLALSVNGSYIRPKDVFDILQLTAMFAGSVLTAIAPRWRANVSSRFVKPKSSDQSEEPDCCALLCQLRDYVYASHHQLEFLKSQCKRHQSHGGWQDCHYGSDVSSPRSPLQSFLTDGWDSAFETHLFDSRNICLKSRVSMGFKYEGLPDESHDGRYLSTILSPTCGGEDPLVTLSSYLVCLTRRTPRTTGELVSFFHHFGNELHLSYSREPSNLGTALSTSHADCPKWDRLEGSDLDAVRQLRGSDSPISSYNHTTTLFTLLGCQVGNAHCHRHCSPITYRAYALYSPLFSHTYLSWTVYLPDRLLESLERLSCDLGRLQCSDISSIHNCAGALPILYTHGFTPPEGTSQSSPKFSTVVTKLEAVLSGDAVANLMTCMDAFLYRVRMPFIFLCFALWSVAMLLFAHTILYRVDIWYIRSHIMRYKVSHLIDVKVLLTLSRNMPSLYDIDYFDDDEELPQTSKTLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCQ3</accession>
    <name>A0A061DCQ3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767896.1">
        <property type="nucleotide sequence ID" value="XM_012912442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCQ3"/>
    <dbReference type="GeneID" id="24564251"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208640"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="8484" checksum="4E894AFE47800161" modified="2014-09-03" version="1">MRRGTNAKSTTARGHLGIDSEDIVGGNRGKYVDCKICRTIRVAGISPLPDFMSHLFSRSIITKAFKECVQAWDWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR2</accession>
    <name>A0A061DCR2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0404400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770138.1">
        <property type="nucleotide sequence ID" value="XM_012914684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR2"/>
    <dbReference type="GeneID" id="24566493"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404400"/>
    <dbReference type="OrthoDB" id="366735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="191" mass="20931" checksum="B0924F5EBDF8344E" modified="2014-09-03" version="1">MVGERDLIGSSDSDFKTHPFDPCNLCLKSRARMRFRDKDLPENVQTGKTVATILSPSCCGGSDPLLTLSAYLNCLTRLTPSTTGELVSFFHDFGIELHGYALKSLSPLGISLSTSHPNSPEWDRLDGTGLDTVCGIRGSESLNATHDHLKSLPKQFGDNLGHLHRHPQLLPTIYHSHALNPSSLTTRFFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD40</accession>
    <name>A0A061DD40_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trafficking protein Mon1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0309820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769265.1">
        <property type="nucleotide sequence ID" value="XM_012913811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD40"/>
    <dbReference type="STRING" id="5866.A0A061DD40"/>
    <dbReference type="GeneID" id="24565620"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309820"/>
    <dbReference type="OMA" id="FRTDNIM"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="172" mass="19049" checksum="C766C0CB34AF277E" modified="2014-09-03" version="1">MGTRVFAFTYAGKPLFTNCPEGEQSLAFYGVLCAVASKVSTLLSEYTSKDELRYISAGDEHFVYLDRGPLCYFGIGPKGESPLMVYKVLSYLHLQILSILTRGVERVLLKRPSYDVQNLLGGTQSILQNLVTSMDSPLSLLDTRGYEALPLPADTRSKLSSFFTDFKSPNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA4</accession>
    <name>A0A061DDA4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768286.1">
        <property type="nucleotide sequence ID" value="XM_012912832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24564641"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300050"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1642"/>
            <end position="1665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1706" mass="191287" checksum="894317E599D4FB45" modified="2014-09-03" version="1">MGFLSGVLGAVKDDEAVKTYDIHPQNNFTKAIETIKKNMYKTGGLSEAVTAVSTALGAWDREVTSRTNSVKILSKSLTQHYINILVNSLHELNICSASDVASKLQVCFKEAEKLNNAFRDAEIQCMSLDNGLQEMIKGNMNSMKVRVKEFVGAANNTELKATVEFTKTRSEELKQAVNSYVKQRVSSMRSNIESEFNKKIHQPMLDVVDRLKGLNSQLDTWIQKAEAVVTKAINQCTNIVKVLKCEEELDRNRTKRQAVETAATNLKEKADALRIAVISAQGELRSRVKTALKQVLILDRAVKMELNELKNRIQMGIGKYVKSIIRDIEVTVNNITGTKGTDGGLKKVVEQVTSWASDFKTTEGFEGKVKDWILHILSDNDFVSEKVTAYGKKLKQLRQGKFTSLGYMDAQGDAENSQYHQEIAEFIKNKLKTDIGAGSQMVQGSLEHDGQGTEQIEKYLHAVGLGCSQFADAIEATIMTKERTIDTPLSTGIYNFAGEIAKDLESELQVMNNSNQSLLQSAVHRILHELLAVAKQTAYDLGWLTSKGDKQGNIQNVAAALSIAKRVETDLNSALNAVVDVSSATFASGEPYKASDNIDRRVSGILDGHLPNGSGGQVKIDSVKFSYYERQIKQATITQANDGEPDPLDGEFPQVIKAIRDNVNGDHHLQRVVNSQAPSTVMNDGKFYNNTFVLLLQQVNDTMQAFCDAVKDLVEKNDKTNTGPNVDENRGVQRLLEDLQIMLNKGADGNRLYELPRHLRDIHEEIKTTIIGTPGSHASSPQTLEHILDAAASFYHKLNTETEQTISEIKTVVTDETDAATEAIQNKARSSYHKKISKMLKYMKSSFETQIENIEKIIDKNLMSGVKGLLRNTKRYFDTNTEQLISQNISSLSINVNVFIARLMSYVVEQTKGHDISNQVKSLSLVCQNMLNELHNSQHFDYKFGTNINNINDRIDSLTPSTLDPQALPDAGRPVLRALREGMLGFVGELGKVYVNKYDGGEGIKKWVKQEGGKDVLTPEGKNGAKVFLTLLEMVNEDLGHLKNECERDWGKFKIYEQDNESTNPLGSFLKRCGFKVAERDTSKDGELRLPLSGFSGDHITKLELFTSIPHTNASKFLVNLDSLITHLNQYNQVGHLRHVKSPRNPCSIFEMLVWSYGLQHNGVYDELVKYCHKYDTSYDKKPDAEFKKRLTDTVDYSLRALSDYSRNILTTILGTGDEYTTYAVDYSDNSLNLKYPASGEDCLHTLLDILRRLLPTLRFLNNQCKLKTKDNGWYECEYGMYTAPAKWPCTAHSSDKATSQPNTQPKCQPTCKVNSQANCQPTSPLQSYLNDCLPGHLPHRLIDVGCKSECKTCSPSTSGMPCVTPLGFKAFSCSTRRGEDICAVLSKFFNVAKLSPLFCLAPKPPSTLPEHMEFALALVKDWDSDATHPLKNSIHSTIRGASIELCGKPEVLTTALTNAYGSYYGSHDTCDDQHISSLTRWDACPAQNKRCAPYLQSLCYDYYSYLVKKHCNLYLSWAVYLPWDFWTQLNNMCNAFSNISCQDWGCRECLRADKCKRGEHGLSVKKDDESEEPNCRCPSIISCKSVSPMLYSYGLTFGHPTKILTNKKCNDFYNQLHSVLNSKYFIDLLTKCDEYLRDIRWPFMLTVLTLWLLSFLYLIHIMVIRLDLLHIKSHLHSPSSHRIAAQSLLAAGRVNKLNRVFYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDF6</accession>
    <name>A0A061DDF6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase copper chaperone (COX17), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0301390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768421.1">
        <property type="nucleotide sequence ID" value="XM_012912967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDF6"/>
    <dbReference type="STRING" id="5866.A0A061DDF6"/>
    <dbReference type="GeneID" id="24564776"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301390"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301390"/>
    <dbReference type="OMA" id="HICCVCK"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="70" mass="7506" checksum="9D8E21FF6EA1EC51" modified="2014-09-03" version="1">MGSALSTGSSPCQPAAVAPAFSKSGKHICCVCKETKAARDECIAQKGEDQCRHLIELHNQCLRNEGFDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDQ9</accession>
    <name>A0A061DDQ9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0401110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769805.1">
        <property type="nucleotide sequence ID" value="XM_012914351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDQ9"/>
    <dbReference type="SMR" id="A0A061DDQ9"/>
    <dbReference type="STRING" id="5866.A0A061DDQ9"/>
    <dbReference type="GeneID" id="24566160"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401110"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401110"/>
    <dbReference type="OMA" id="DVRCECE"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="120"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="351"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="496" mass="56802" checksum="F3330B4BA61DD4BB" modified="2014-09-03" version="1">MRSRSRSHSRHRHRRHRSSRERSRSRSRSRSRSRRSSRYDRDSRHDYRGRDRSRHSRSDRHYERSRYDDASRRKNFRYDSPPKSAHRTRRHHVPDALITNAYAQGLGVLGMDPVATKPYREIYIGNIPPHADVNNLLEFLNEALVAVNGTSVPGGACQKGWISADSHYAFVEMRTMQEASNCIQLSGINYLNYSLRINRPKTYNPDVLTQAPSPTIPTLDPSLLALGIEGLKCASEQIAAAADMLATERAKTMTDRLCVENVTDEAALKREIEAMGKLKFYQYVTEENKQPLCLFEYEHIELQKTALEGLKERGIEVVMAVDALERGALSEEFIRSQILQCDIMKAEIPTRVLLLANLVSKEDLEDDEEYYDIIDDVRCECEEYGRVIRVELPRVPKGYTLDEIRTMDFSSVGCAFVLFSEVDGASKARKVLDGRKFGHRIVECHYFSELLFHVGEFSNPKPNFSKEHSSVYNPIIAEDPNQAGDILNELRKEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDS3</accession>
    <name>A0A061DDS3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">-Thioredoxin domain-containing protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0401410</name>
        <name evidence="2" type="ORF">BBBOND_0401450</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Bond</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769835.1">
        <property type="nucleotide sequence ID" value="XM_012914381.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769839.1">
        <property type="nucleotide sequence ID" value="XM_012914385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDS3"/>
    <dbReference type="STRING" id="5866.A0A061DDS3"/>
    <dbReference type="GeneID" id="24566190"/>
    <dbReference type="GeneID" id="24566194"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401410"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401450"/>
    <dbReference type="OMA" id="CVIAFID"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="217" mass="25089" checksum="2DCD6938C2865349" modified="2014-09-03" version="1">MAPTHKESELVRKVHDNVLAALLQKEREVEDELESIRHVESKIAHMRDEDALERFREARLQALKETHAKRLEFMNKGYGKLVDVHSDSDFFDVCRNAHYVVAHFYRPTTVRSQYLDGKMHELCQTYFDTKFIRVNAERTPFLCERFNIWCIPTVSEAYDSLDCVQLMIIIGGKTNHSIIGFDEFGGDGFTLDEFASALKKRGILPPDAENARNKHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDX0</accession>
    <name>A0A061DDX0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallopeptidase M24 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0305530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768836.1">
        <property type="nucleotide sequence ID" value="XM_012913382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDX0"/>
    <dbReference type="STRING" id="5866.A0A061DDX0"/>
    <dbReference type="GeneID" id="24565191"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305530"/>
    <dbReference type="OMA" id="LTHFRYT"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="320"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="555"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="624" mass="69372" checksum="DF0BCBC9FFDF2071" modified="2014-09-03" version="1">MAAEASPTQMLMSLLAACQLDAIIIDHDDPHSTEIPHPAFGALEFVSSFSGSWGKAVVTREGAWLWTDSRYYIQAAQQLSPPWELMRYGQKDVPDVVKFLKEKPFKRVGVDASTTPHKVLTHYKDNLKDIEFVELHDNPVYKVWADRPQLPVDPVFVHPESFTGMSAADKLAKIRSEMDKAGANAVVFSLLDEVAYVLNLRGRDLDVSPLFYAYLIVEKGAATLFIDSRKVTDEVEEALRSCNVTRADYGELPGYLASITGSSEAQKPGDKFKLWVSPCASVAICNSFLSNASEKMPRELLQEDTPACIMKAVKNDVELEGMKEAHILDGIALAEFFAKVEAMKSDGTLFQSDEMVLGDLSTQCRADLKENRGISFHPISSIGPNCAIVHYRATAESKAKIEPQMYLLDSGGQYGGGTTDVTRTVHFGTPSAEEKESYTQVLKGHLALRHAVFPEQTPGATLDVLARQFLWSAGRNYYHGTGHGVGAYLNVHEGPMSISSLMKPRMGNVNVVYLEPGMVLSNEPGYYKEDHYGIRIENMVFVRRVEGDFSKDYTKFLTFDDLTMVPYCKELMDLAMMTEQEVEWVNEYHALIAATLIPRMEALSIAKYAAAIQFLRDAAVPLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE02</accession>
    <name>A0A061DE02_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770020.1">
        <property type="nucleotide sequence ID" value="XM_012914566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE02"/>
    <dbReference type="GeneID" id="24566375"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403220"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403220"/>
    <dbReference type="OrthoDB" id="366618at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28537" checksum="7E250B3D13EE765C" modified="2014-09-03" version="1">MVYHSLTDVPRNLKECLDWLIAVKGTSKFNTQALGYALYNFLVDKPVGTTYVPSVEKVKRLSREFMQKKEFKDLPAVGDLLRRFTERMNKTDFVDIKRFFALHESDYENIVKVNGVTPDSIAKDVDKIADGCEQFLNEIKTPGQYESAYSSEATWEASCSKRPEDCAAVLVGIAPMLYAGLHSLFTGSNGHHFGTPPPNETLLVSKVMKAMGFVESKCRDGLSRSDLRHAFRDMHMDVLDTIYNFAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE28</accession>
    <name>A0A061DE28_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0404020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770100.1">
        <property type="nucleotide sequence ID" value="XM_012914646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE28"/>
    <dbReference type="STRING" id="5866.A0A061DE28"/>
    <dbReference type="GeneID" id="24566455"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404020"/>
    <dbReference type="OMA" id="MSTIAMG"/>
    <dbReference type="OrthoDB" id="365234at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="521" mass="57761" checksum="26E0BF87DF46FDE9" modified="2014-09-03" version="1">MGTAKCEEQKNKSLLPSVAAFLKGHSLMQPLQVCLLGSSFAMQRFGYSPDAVSTFVGTCHTAMEIFYLFSALSTFGILTALRSIWKLHADEYAAYGCVCSAWVIVIVNVFLLKAFALGKSNETIALYFWMLIAANCVAGIDDMFMFTVASDDVSSYDLGASFTGIVVGLFHWCALITLKKRNMDVNYWLIFYQLVAILSLSLGTAVVWTWYTFKGGLLDKIKKKGKSQAASKGSENIKEDQTFLQAYWATFAMTLMSSIGYGFIYVIYPLISPFEMVEFEHQHPIQTACLVIHAVSGILVWILDKHCNLGKKWVGPLAYYHFIWLLAIPFFGIGIMYIRIMHYPKSLIARGVRMKPVLVGFLTVIYYFSGRFFIGAACAAIDGNAKVADAKASNASQSDCENTNSGASDSAGSSGISQAGSSSESAETSKKSDHASTISSMNLALNLLVLNIVKYISEAYIEHFRESREEFEYGEPWPTEGMGEREAFFYWLKEGAVLGFKNFRKLAVQNIKAKLAPYIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE61</accession>
    <name>A0A061DE61_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0404940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770195.1">
        <property type="nucleotide sequence ID" value="XM_012914741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE61"/>
    <dbReference type="GeneID" id="24566550"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404940"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="6-Cys" evidence="8">
        <location>
            <begin position="805"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="934" mass="105784" checksum="68ABE256DE28FA27" modified="2014-09-03" version="1">MEYDFTDSMSSLYTNALVAFHINVDDIGIATLACPRQVNRTEYVWHPQPTAYHGNTLKTYVIEDGKFHSVPFSKVVVNEAPRAYVRKVSKESQTELHIDLMDDHIYAITEERVAFICGPRDLVLSDALQGQLAHLREIDETEIYLWNPTTPLVGEIAKIGKSLGVVFLHRGLNHQLMQGCGSRPSKLFAPDNDVTVDPVTGTRSCVVNPMSTLRTGFVCKGRIEPNDCMRYLLDSTGRVVTAPTPHLYRNFNNRGKWVVARYFNDVALPRFNGECRCIDPETGHVKARMEIRWKTEYVCDIASMIVRNRFKPIRGTWCSALLHPDTTLTIKLPKQTDKSAATGEKYEEDVDDIDEDDSTVPFSQLPSTHAYDSEFKPDTELTLRQIQTIYDINDYDEILIYEAFTGGAIEVDVSQVEGGEVKLKYRMDRPLALRKGYNSFLYHWTFISRNEYVLEKIRAVVNVSFAPTYRFNIIGCDRWRPSMFDPANDIDSLTIRDMGHGMALTSEWVLNVMSGEKQAGIQCGDNEELLPNNCESTGYDLSSNKIAPFPTAVRNVTLYPVRRFQVFDMSFQNIPVSHACSCVDEHGYETSRLILRSNRREEYTYTVRREEAYQRLLPYSLLPWSEVALFYGVSNPMRSIVLHNMPQGPITLHSGTEIFMRCVLDGGLYDDENNAVASPTWLPYDRGYNHYKVYSTAEGHRLIRKSHGERIAGTRGGFKVILSEYTEEYRGLIIKSNSGAILVSRDPDHSEYVPMTFICGKEFSESDFDQSNDNAAAAAIPPPVALLEEYTWNVVQIDVEMTDPYMQGCGVKSSSDELFKPDTPKLYDAEWQEIGCEIDIEIAKEAAFYCPAPYVLDPPNCFDQVYVNGEVKNLTEISKSLIASASSHFVTLLFDSARIGPGENLHQTPPLQCRCVTIKGIVLSTIQIENYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE66</accession>
    <name>A0A061DE66_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0405040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770205.1">
        <property type="nucleotide sequence ID" value="XM_012914751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE66"/>
    <dbReference type="GeneID" id="24566560"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405040"/>
    <dbReference type="OrthoDB" id="10397787at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR98019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="331" mass="36495" checksum="9D76E0D7633A1DD8" modified="2014-09-03" version="1">MVFNSLTEPPRDFREGIDWLIALKGTDAESNLKAVSDAVYNFLADKPVDPSQLQAFQKVKQNTKAFLERDVLKDQSRIKLMLTRFNRPKDEKYNIFAKVTNNEERIDDEKLRKVWGITADNITEKITTSVEGCEKFLEDIKIPDQYVSAYSSEATWEKSCSTKPEACAAVFVGITPMLYTGLMSLWDATDADNFRLFPSKAKKNLGDLLNALRYVKPECRDKLDRPDIVNALSGVGIEELDTLMEFSEFWIFHGSDNDGAAGLEAAKPAGVEEVIEPVNAAEPVNALKAEKPGKPEKSGKSGKSGKSGRSGRLGKSGKSGKSGKSKKSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEJ5</accession>
    <name>A0A061DEJ5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769576.1">
        <property type="nucleotide sequence ID" value="XM_012914122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEJ5"/>
    <dbReference type="GeneID" id="24565931"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312930"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312930"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="91" mass="10598" checksum="1BBB9ED69BE0C545" modified="2014-09-03" version="1">MWYLELDFTDAPNFDEQLLRRCLSMLVDRWEWVARPCGFHPIWANLGKYLPMYELIFRVVAYIVSIVISLEVVTPDCTLAEASWAPANMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DER8</accession>
    <name>A0A061DER8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769941.1">
        <property type="nucleotide sequence ID" value="XM_012914487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DER8"/>
    <dbReference type="STRING" id="5866.A0A061DER8"/>
    <dbReference type="GeneID" id="24566296"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402430"/>
    <dbReference type="OMA" id="HDTISRH"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130225" checksum="447132CDE0AACD28" modified="2014-09-03" version="1">MGMFGGKGCGLLVVSLVVSIFAFATLSVILFTLNLDGKNTFKPYISDRFVLPFPSLFEEFELDSNVSQKSSVQGSRGSPETCWRRVAPEYETYVSGRGKVFDYVAPKRFTVGGDMPAGWLSYTPIDSSVIVVVDGARVDYALYDPTLKPGEPRAVFTNHMPLYHDYLHSPTTRNYSRFFRFEAPTPTFTTFSFKCLFTGESRRGNMWQVVGAATAVQLEIDNFGNQLAHNGDKLCLLGDVISYDLLGPERVFMKHTGKGIDIYDMVFPDSLVSSHYAEFLDQCDVNVLHLLAIDHLGHSGKRVSADMTYYLDDYDAFIRQIITRAFEKSNVMVYVLGDHGQKTNGSHGGATKEEVDSFLFVTSDLELRRVTSDMCDLNDAPTGYAREHNVLNGRVSLSYPVNKSAHINVASSLCLLMNRPVPFHSEGSIIKEIVPLIKDARGNVNKLLSVKYLTQLLHVVAHNALRAVDTTIPDSEKQKHKCKYAAVVRERKVLSHYYSFVRSMGRDQVEPAAMVDICNSYIRQCERLIAATKQMIVATNVFLTPEYMVLSTLFMAIACLLSAYLLLVACRICHVRKLSEDELVFFEARKFPTIGRIMMRGLIKLVLAGAAAWAISAQIDQVSAQVPTGIAVPRHLATSVLKRFIMPFERWCDIEAPSPWFYLACYLCLLFVLCFLLDVPFFVRNFALLYRERKHFAQPLPEGRYDGGLRQLLSHMSGVNPVAVAVILYVLLAVKTIVSQCAIISHDTALRHAVVLSLYMAMFPAVKRTGSLRLYGAYRNFGVLCFVLKFSYLIHRFEECRSIGNMEPQWYIKVNDVFRTFECGAAVLTVYYFTLLRLTRHPVNGGDAAEMSLPLKAIRRSPMNRPLLRGVWTIQYVLLMLHYAMKCERHYFSRRVVSWLSMHLIKVRNPVVAKTLLALYSARAMAVLTMLVWLTLALDFRGTIYNLEGVPHSRSNRLFWFLTNMLWMVLLLNGPKKAVGAFAFALVLYNTSSLFAKLSVRSRLMCTVVFLLFCDLMYFVAGHQDSLFQLDFDSAFLFFDTYVGLPCDIAVALAFAIFNITAICALQYLFVSESERDYLAKLSETATSGSAKTGADKPSPKASATAKSTESKEFSHSDLASWIACDSFESVAGYTFLALARLTLTLGILFALSGNQCVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DES1</accession>
    <name>A0A061DES1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase, alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0402580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769956.1">
        <property type="nucleotide sequence ID" value="XM_012914502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DES1"/>
    <dbReference type="STRING" id="5866.A0A061DES1"/>
    <dbReference type="GeneID" id="24566311"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402580"/>
    <dbReference type="OMA" id="CEDRCEF"/>
    <dbReference type="OrthoDB" id="360088at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596279" evidence="3">
        <location>
            <begin position="22"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="257"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR97770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="676" mass="76178" checksum="0CC3392B868DE6B8" modified="2014-09-03" version="1">MKNAGFISLVFFSLFSDLVDSIAVRDKNPCAAPTLALRLTPQLFITRHRRALEACYTCNPQRLPIRLHGSRRAGRLRIRALNPEKAELHPESLSGVEPSVTAERIDELKRKGIIEGESHTWRNWHVVTQGQWPDIGQPVLPKSARNPSITEPYALRKPLEYWGFLRGVDTNITSYPLVWEFYNDTYGKVDVAAYGGSNPLYTPSMFQPTWFMEEDRGGLGYNDCRIFGGWIGLDLDSPTKVKTASELISIPDTGRLYQKFYLGPYPITMGWTIGSLLKVLTLSRSPGHGVVAVKIHNMREDTTIPGVVDDLLNIALNLNGVALETLKPGEEARVRMLLRGPAMVCAGSLEWPSFVRVASPDTYIAKIEEGGELDIELKIEWGRGVWLADDKGLYRQEEGADGVCMKRRWIKEVQEEGFYPMTTFFGGCRMVRLAVHKLLGQRWDIISNSCPDPREQLVVEVWTDRSTTPKAALEFGLLESLAWLRELKRQLSQDVDFDGEDEQLRDTWEKIDKYQALQHRQDLMGGPPVYNLHELNLSPPVKESDCEYIGTPDDVKEIPQAPYSLPKIPPNRPQKDTLEWLADELQVEEYTDPSPINARNFEKFTSPPEDAAAAVDVSVLPVAPEVIASLRMCGFNNVGDMVSLSSSELERYPDVSPEDAERIVAFIRTNLKLQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C5NTJ8</accession>
    <name>C5NTJ8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calapin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Calpain family cysteine protease domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">calap</name>
        <name evidence="7" type="ORF">BBBOND_0306660</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2009-06" db="EMBL/GenBank/DDBJ databases">
            <title>Charactrization of Babesia bigemina calapin.</title>
            <authorList>
                <person name="AbouLaila M."/>
                <person name="Yokoyama N."/>
                <person name="Igarashi I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Argentina</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2009-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aboulaila M."/>
                <person name="Yokoyama N."/>
                <person name="Igarashi I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Argentina</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AB510031">
        <property type="protein sequence ID" value="BAH79727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768948.1">
        <property type="nucleotide sequence ID" value="XM_012913494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C5NTJ8"/>
    <dbReference type="STRING" id="5866.C5NTJ8"/>
    <dbReference type="GeneID" id="24565303"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306660"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306660"/>
    <dbReference type="OMA" id="GDYRRGC"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="5">
        <location>
            <begin position="90"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAH79727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="896" mass="98917" checksum="F6C2B5CF22612FE0" modified="2009-09-01" version="1">MAPERCSCFARISRASLRENGCNNGGCDVADTIEAANADNPLLDSIVLGSSALGNFIAPPWHLISPCESSVVNKLWEDPEGHPELTSKQKDRLYRWVRFFWGSGRKCFFAAAPDSGRIKQGFVADCSFLSSLAVLADYESRYSVPLLSNIIKFVSIGPHGYADLVQPTQTCTEAHPSTNPGTAIGVKLYFNGIARCVVVDDWVPIRADGRLLCAHSSDRTECWVSILERAFVKLNGGRYTIRGTNPGIDIYHLTGWIPDIVYLQPSGCIPSGVAASADRSANKWNDMWDVIYAGFCGGSCVVCLGTSDFADALPVGQDRPEGISVSSGIVSDHAYSMIDMKEVQMPNKRRIRLMYLKNPWGSISWTKRFSPSDKTSWTPEMQKTLNYVPNASEDNGMFWIEWNDVLKWFSHLYVAWKPSLFRSRVTLHHVWEPSSHFLDSWAPDDMSLSLYNPQFSVVISFGSSNSATLWLMLIQHRVNFEDPLKYLAMHVFSSRDAVVCPVLPDVQGVYNNGECILLKLIVKLSSFSESPGKHMLTGDPVIAHTLDDESSVTVLVSYYSRKLERAIPFTIRALCSRPIKLTPKPCLVRPDWYSTVIHGEWTDGNSGGSPKNIWTYFKNPHYRLYFPGECEAVVLLESVNPLSVNLRIFTGRMATIRALKAGQLVSSDDYRAQCCAVSSTNFCGQYVVIPSTYRATDRGAFRIIVHSNKECSISPLPYPQSPVPSTAGLISQRFDMQGPLNMQVSCPTLVSIRLKVPTELLSDNFALLASSAGASHPQPRDACTSFDGLNKHFCVSLACSICGGAGGRLRQITRSDPLSGHAEGYDLVLYSDLNGGNSNTGRTPSASARYLFDNERVINFTLVELQPNTVPYRLCCISGVSRGAVTLISDHPVSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYN9</accession>
    <name>A0A061CYN9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial GTPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0100750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765932.1">
        <property type="nucleotide sequence ID" value="XM_012910478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYN9"/>
    <dbReference type="STRING" id="5866.A0A061CYN9"/>
    <dbReference type="GeneID" id="24562287"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100750"/>
    <dbReference type="OMA" id="GVLWPKF"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="182"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="387" mass="44034" checksum="03032B87A3665F44" modified="2014-09-03" version="1">MDVIRRYRQRVGRPSGPSLDDFIYRRPPPTYDQNATVFYNPTPSTASSAMGTSATFKPREKFIFDRSITWFPAHMASAKLNIGKKRRAVDCILEVRDARAPLTASNCTITEEYPEHVPRLVVLNKSDLVPQQDMQRAVQLLENTGRKVVLYSALGLRKITKITNFVREHVTPQFKTLGVWMMVVGLPNVGKSSIINALKRYSFTQRWHSKYAMQQPTSLTTSKAKCAGVAGSTRTLSAFFVSENPKLYCFDTPGVMLPKMQCPEINLKLAAIGCVDDHSAGVDYIADYILYTLNRKRMFDYVNVLGLPGPTDDVKEVMEHISRIAERKYSTVEPSNCYRIFINQFRQGNFGLICLDDLNDIIRRGDLSDFELRWVQSILSMERIFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ45</accession>
    <name>A0A061CZ45_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0102250</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766082.1">
        <property type="nucleotide sequence ID" value="XM_012910628.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061CZ45"/>
    <dbReference type="GeneID" id="24562437"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102250"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102250"/>
    <dbReference type="OMA" id="CITIAYN"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="18">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="16">
        <location>
            <begin position="671"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="15">
        <location>
            <begin position="937"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="17">
        <location>
            <begin position="1535"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="492"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR93896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1630" mass="184697" checksum="1144C3F3A892471C" modified="2014-09-03" version="1">MDEFKEFIRSNARVAVQLVYYDHVMCKPIEFDPQVSSTGVPVVEVPVIRVFGGTPAGQQVCLYIHGYLPYFYLPVPDNVAPSKFAQKAHKVLERAARKIVVERRRLRGGRRSRGSLQPKLPNTNDNPDDKDSKQSSCGTDSSQTEETDSFPTSRWFSSRSRLLSQSYHRLAILRQKKTATTAYIHRVDVVEHVIFYGYHTQPRKFLKVHHYNPSMTKHLAGYAFNHGIRKHRLQPYEVHISYLMHFLSDYNLRGMDHIYLSSAIKMRGPLPLHPHYSVQAHPLWQRVVLASIKNTPDDLATVERPVLRDSPSVFLSSHQRRSSCELEVDAHVASILNVFEYHNASDPQSQEVTERGYAVGRYMGARHAFSEQWKQQCTHLQSSSFSPFQTNDRAFTAYASRNTLKQFYSYLLVQAEGLPEDKKPAVVSRLRQLLSQCDDLQGRRKRAPKKTTQNELITISSAFFHTSQDYRPADEGDQYYVYRYAIKPPEVEDADSVDVQDGKKVPSGKENKPSRVDGESVSTRQTNEPSGKGQTRCPNLLLSVKDTQAQTNVMASEHARENNPPIALEPVSDIVGTTDNFECGIALDVITEIDLNCIHANPEVNAINAVVYTLRDHRLAPHFDAVGVPYADVQGAIVVDVSGVERPPPRRINIEEFYRMALIQRCEVDMNVVERQINSGKYVDVSFVPSEMALIDSVSRLISQFDPNVIYGYDMARSSIGYLSQRAEVLGIPYFLEAISRVPPRLRHGSGNQGDRVTDMSTLLTHQRSKLKKRHLSDSEVKPLFSAGRLLFDVADVAVRELNLANLTLENIVRDQFNYVMPSFTMYTMNKWLTTKVSLLQSGDAKGHEADAAVAAPGNAGFNGHVNGNYRLRNAVQMSLHRRDHRNNRGNDVMITPHRFRAIRYALLRNYAVIATFDKLMYFQRYTTFSKLYGLDLKSTIVRGSQYHVESVLIRFTKSFNYVLPSPTRRQVHQQRPSVAIPIVMQPISGFHLAPVAVLDFQSLYSCITIAYNICYSTCLGLLSEHKTWRHRVKLGVVTYHPEEGVFRGILSKHAELPGTEEGTVGVHIMPNGVMFVDKSVREGLLPTMLTSVLQSRRKIKAAMTRPGVEGRILRQWDREQYGLKMLSNLSVGLTASGYSGRMPCSDLAESVVSIARALLVLCMELIHDNFDAEVIYGDTDSIFIKFPGRTVAEAQSLAEEIANKINSTIPEPIKIVPQKVYCPCILVSKKRYLGLIHLNGKMVFDDKGVETMRTSECDATRKILRQALDCILRNRTLDMAYDGLASVFRNVASVYTPKDFILYRQVRLGTYREELTGQVGTLPAAAIVAKHKLDKHYGRRVLENEFIPHVFSTSREDVYRGVKGGAVFPNEINGIFRPTDFVKEHGRRTLPHNSMACVLEQIRRGQPLHQIDVDYYLKKQVLPPLKRVMQLLDIHPDYPIASTIIERLQQMQQRKEERFRRVDEPGKKVGEIWEYTDPLARCTSCGTTCKVKLGTAGHNEVVKDDRKDHISQNLADLLHSKEVRITTIHQDVLSCEDSTKGKMHVVVCEGCRMNPRQTLLKVLNEMNALEEKVHAVNNICLNCTGSAASSASCQNAWHCDVYFKRISYKRLFARSLKEYRGLLTLAYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZD6</accession>
    <name>A0A061CZD6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mac/perforin domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0103080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766172.1">
        <property type="nucleotide sequence ID" value="XM_012910718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZD6"/>
    <dbReference type="STRING" id="5866.A0A061CZD6"/>
    <dbReference type="GeneID" id="24562527"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103080"/>
    <dbReference type="OMA" id="EPKREGI"/>
    <dbReference type="OrthoDB" id="5954510at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595601" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="3">
        <location>
            <begin position="861"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1206" mass="135708" checksum="AD1E7148826D1726" modified="2014-09-03" version="1">MKLIVAYITTIFSLLAFRAQSFSIEMVMNRCVLGPGHGCTPKMTIVTKGDAQPIIEVMKLNDGNVPSVEQSHAHYNTDSEADNDGYVSSDVPSPTGFPMVCERCYKDISPRRSSSSFETEKNNALGNDSSEGDNDSVKENANDDDQDEEEFVDDDDSTDALDPDEYAMRGYEDSVGNGQTSYLEMERCLQYQRMGCPYTLRSQRSTYNPQYYTAFSPRYARTDDGAQLDSSSDDNRASGDETESTCPFANRSQQPLYYSYSQPQYRVNYKPTCRRYIRYFSPCRPRPCRQTGYQPSRYGNSFNNEINYALEVVRPIERSEDYESESKGSTFQVNHNDSNEGDENGNFHTRDLINDSENGRDASTTVRVTNGMFNVDVGKSADSVMKHYRDLQTERAATNAGVKDTGNTEKTDDIYNMSFIETARQISYANNYASVAPHLRNQPSGGMMSNGQKDPTFYELGSNNNMTPTNGITYKKRNRDKSVARLREDDDYAVDFDNFMAEGLENNGANENEANGDPELVGEDYDDNEDDNKAQLKEQNDERDDDYLEQIDQRENDEHENNKHENDKHENDKRDNDYLDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEPKREGIDEILEHENEGIDEILEPKNEGIDDILEPKREGIDDILEPKREDIDDNGNDDEADAETANDNAEKEDGEMENDVSNATAESSSPTDDAFPEDSDDESDDVTDVADYIREQNVDVLRTPPGLEYLGSGYDMVKGNPLGDTITLLDPGYRANIIQMHWRKDFEGVSNSLLYMQPKGAWVRSYVSCHKSDTVSEVGKSKSLKNALSVDASVSAEVPGDSLKFAASASYNNVKNSESQKGLKKYVSRSYCLNYVAGIPSSIPWDYTTAFTIALKQLPTKFEHERDGVICSPSIYRDNPTSKACLDLGVRPWMRFFTIFGTHVTTKIYLGGKMVTLIETKASQEAKLKKLGIDVKAEISVQAQVATANGAVGVGVSKLKDSKNESLDSKKSTLALGGDIYGKGKNLSFNDWAETVSSFSMPVKAEYTPIANFLGKNFVDAYNDAYVFYGKVLVGENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D007</accession>
    <name>A0A061D007_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766189.1">
        <property type="nucleotide sequence ID" value="XM_012910735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D007"/>
    <dbReference type="STRING" id="5866.A0A061D007"/>
    <dbReference type="GeneID" id="24562544"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103230"/>
    <dbReference type="OMA" id="AWWSIES"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="510" mass="56823" checksum="E4FA78C6DFEEBB7F" modified="2014-09-03" version="1">MDVATLSCSVQRVNAYHFTYNLHMKYKQAEWNIEKSFSDFEQLQESLVFQEFTDVPLLPDLQLSGSLDPMGDVYNAEVAIEKFIQEVLRRPDTRSCTDVLIFCDLLRHLQSAPPPVSATLLTSTPASHLAVSDVGNLENEGIMIVAYEEKTALSKIGRMWSLIEPDVLGAVRVFKMGANVTDEVTKVSEQLFHHKVRAIKYMPETSTLVVAKDDGYVGIYRMENQWTEFVSISSLALHSGPVLSLDMMKHLGFTSGYDDTIRCFDVTLPKTVSGGKLTKRLNGDKLLASAVAPPRTMLIGTSSNKIYTYYMMDELPVFVDSCEVPPPMNIRKIHCTSSNVIVAHGNCVSCFRYSRSPLDTIRELKRPKGSSLPPVPREMTGIGFQREPSPAVPSETQSNTATISFPMSIRSAQFSVNTSTSSFSTYQVYDFAFRPQAKQLLVAYDEVVAIWCVARGVMLYSWYAHRHAQVHVLRVLEPEGLVVTGGSDGEVRIWRLPDPSLLILGKAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0C0</accession>
    <name>A0A061D0C0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766462.1">
        <property type="nucleotide sequence ID" value="XM_012911008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0C0"/>
    <dbReference type="GeneID" id="24562817"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105850"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="252" mass="28380" checksum="D2083FDC35DB7B26" modified="2014-09-03" version="1">MVYDSLTDPPHNLKECIDWLIAVRGDDGKKNVVALGEAVHKFLADKPVGKMEVPALEEVKLITKEFLEKPELQNRRAVRAILRRFNKPMRKVGFCHRLFGRIVDSDYENVIETKGLTAENIAENIGEIVEGCKTFLDHIKIPDQYKSAYGPEATWDASCSEKPEACAVIFVGIAPMLYAGIQSLWKICTARVFKASNFEAEKHMPKVLKALGYATPEFPPDLNVLNVTCALLGFNRHMVTNIYDLAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D199</accession>
    <name>A0A061D199_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766772.1">
        <property type="nucleotide sequence ID" value="XM_012911318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D199"/>
    <dbReference type="GeneID" id="24563127"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108840"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="130" mass="14325" checksum="152A976BA23A579D" modified="2014-09-03" version="1">MPFVCKNSICDVQCKGKENRCQCDCCKRKCKNKEVEVCKAPAPQPLVASPSVETETSAQRGTSDQESNTDNRNSEASTLSPPDPQAIAAVIVAIIVAIILLDLCIFRFPVGRNIRDFLVRKIPFCIAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1G9</accession>
    <name>A0A061D1G9_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0109440</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766832.1">
        <property type="nucleotide sequence ID" value="XM_012911378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1G9"/>
    <dbReference type="STRING" id="5866.A0A061D1G9"/>
    <dbReference type="GeneID" id="24563187"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109440"/>
    <dbReference type="OMA" id="ILMEMCN"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13996">
        <property type="entry name" value="STKc_EIF2AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="582"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="803"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1068" mass="121048" checksum="CA8D7F8783327AFA" modified="2014-09-03" version="1">MSLVRRGRRSLPQLTGADADGEVSLIVLDTEGLAYCTNLSRHLMWVTRLTDNLLNVKKPYVETPNNVCALNNAPTRGMGWDREKYEEHTTADSQNGKAFKTCGRNAGAKAKCARHLVPSYDGYVYCIYETGHSQLLHIHVRDIVNFTPFRTPLLDGVYLEGSRNSSVMALDFHTGSYIARNLHDVHYKTHPPASPDQPERETQRQLHIGYTDWTVRAFDEKSHVELWSFNWREIGAVNSENVGPVVVERVREIIKVQGQKLAIDFEDDEGKISEEMNFPFPIAAVFAVLWNANEEIMTLQIVERISIPPPAAFLQNALDKAYGSIKLSSSSYFGRNLVSVKGGVINVKNMWDPEVDGEAANDGGRLITIKMVDKNHYYTLDTGLQPLTFTQQNHTKWQIVKWWCVLTCWLLTFALAPLMNVLRILKECIDRKIYHRRWWAKMPFSRFLLGQVSLMIDDFERGIFESTERLIYNVDRISPLHSVDNVCQTFTVPLKLINNTDEMLEIQRQENRSQAGSAAQSARSEESEGHELPRVELAVETSEINYSDDEMTREDELRAISVVPAATALANFLENGRFLRTFDCIKLLGKGGFGSVYRAQHKLEPGHPTYAIKLVLLKLKASEGLTSRRYFREIVANREISSKYVVRYFTWWCEEPHFLPLTQLTPEIQSAAANNVKHLVGSNSLNTQRAKALNGFMQHYQEMLRGILEKRSDEDYPSFSNVAFNNSLLDERGRVGRRVRLAAIGEQTGGSQLNTDEDDSMLNGVCAFEFEDDNYEHDGRYPNVPQSESSQGIVFEYSNTSRAPAVGFDGESPRENSENSDDGDAEESGNCHQARVRDTEKQYPVVLLILMELCKGFTLREWLNRPGRSDKPMQYTLSPNGVPVEFDLFRQLIKGLRDIHANNFIHRDLKPENVFVDPNTNALKIGDFGLVGFISQSTRETRDTPPPEATAQQDSCESSLPGQLIGTPGYAAPEGGFNCSEKADIFSAALILLELLSPRFHTVMERFTVLENFRNTGRVPEFIEQELSPWHRLLTEMADRVPQRRPSAVEVQKKLKGLIAMWCNEPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1H6</accession>
    <name>A0A061D1H6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0109490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766837.1">
        <property type="nucleotide sequence ID" value="XM_012911383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1H6"/>
    <dbReference type="GeneID" id="24563192"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109490"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="60" mass="6589" checksum="114B66794D4B088A" modified="2014-09-03" version="1">MRSVKPREDYDSVEDPQAQPGWMPAWMAPVTIGNGQTRNPQPVPARGGSLGKLNSRTSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1P9</accession>
    <name>A0A061D1P9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YOU2-like small euk. C2C2 zinc finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM136 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766243.1">
        <property type="nucleotide sequence ID" value="XM_012910789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1P9"/>
    <dbReference type="GeneID" id="24562598"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103710"/>
    <dbReference type="OMA" id="AFECCVR"/>
    <dbReference type="OrthoDB" id="9975421at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008560">
        <property type="entry name" value="DUF842_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096:SF0">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05811">
        <property type="entry name" value="DUF842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="153" mass="16512" checksum="92A5FDE1816DF9D6" modified="2014-09-03" version="1">MGWFSSSDSGASASGSGEAVGLMARAEAFQKQVDGMLTEVTRMSLPLQKSAFECCVRCFDGGSENLDKLGDCVKQCQSRPEKFGNAVQGELNQLQDALMSCQKKCVDQFSSKGAGASESISASMERCAVQCYDNNEGLLRDISSRLTSIYRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1R8</accession>
    <name>A0A061D1R8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766263.1">
        <property type="nucleotide sequence ID" value="XM_012910809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1R8"/>
    <dbReference type="GeneID" id="24562618"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103895"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103895"/>
    <dbReference type="OMA" id="YSGEREF"/>
    <dbReference type="OrthoDB" id="365470at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="194" mass="20887" checksum="B9F4B7CFA76A33E7" modified="2014-09-03" version="1">MESISNVHVLPCLIKEQGPADVARGFSDGVFSLNAASSDAADGLCGFTLLDVCGQVAETVPFQVEVTEHMEQDVYASQHGTDPLLGRERLCAFLRGRCLRGSQLDLSALGCRLSMVEVSPPSSSSSRKSPIASNPAIRSQTLRETAEVKALTVWDQDRDISPLEPFLAGYKHIALASALSDYSGEREFVERSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D298</accession>
    <name>A0A061D298_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">26s proteasome aaa-ATPase subunit Rpt3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0105360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766413.1">
        <property type="nucleotide sequence ID" value="XM_012910959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D298"/>
    <dbReference type="STRING" id="5866.A0A061D298"/>
    <dbReference type="GeneID" id="24562768"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105360"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000293">
        <property type="entry name" value="26S protease regulatory subunit 6B homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="180"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="414" mass="46853" checksum="D262E0752B5502AE" modified="2014-09-03" version="1">MAAKYLPRKVSPSERDLYSKLKTLEKQLDLCDIQIIKTQENYVKEEHKNLKLELLRAREEIKRIQSVPLVIGQFLDMVDKSHGIVSSTAGSNYYVRILSTINREQLTPNTSVALHRHSHSVVDVLPPEADSSIQMLQLSDKPEVSYADIGGLDAQKQEVREAVELPLTCPELYHQIGIDPPVGVLLYGPPGTGKTMLAKAVAHHTGANFIRVVGSEFVQKYLGEGPRMVRDIFRLARENAPAILFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNATVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITSHMNLSSDVDIENCTFILRNENRHVAVVARPERISAADIAAICQEAGLQAIRKNRYVVTNKDFQKGWKRHVKKQDRDYAFYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2B0</accession>
    <name>A0A061D2B0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0105460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766423.1">
        <property type="nucleotide sequence ID" value="XM_012910969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2B0"/>
    <dbReference type="GeneID" id="24562778"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105460"/>
    <dbReference type="OMA" id="DECHVEY"/>
    <dbReference type="OrthoDB" id="386672at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="562" mass="63321" checksum="E6F91745CBAFA846" modified="2014-09-03" version="1">MVKRYTGFSAAFNNNRASCTSEGILHRCLKSVDFLASDDEQTVSFVKRRCVSTVLTGHMTENLKTPLLSDNFHLEHPEAQQDIREGFDLNNCVCNEITYLKTLDIFRNVKSVAVVGSLTFFSTFHLEKLLVQSGIKVASSATAANCIILGWWIQGGVLDSIDKSTRIITEEEFFDSLTVGVKERCKHIKFQRYTNILEKRNGRRTLLKDALHPRCIGHVLGHKDAFRMFYEFLFAAKVGEDGKSEPHVKGRNVCVIIYPPGCGIRIGIELICNAMGYWCLYTDLGISADKLTAPKEIKPINIYCREVLDTLTVEQIVEANKIAIVMIEDIESKYIAFSRPCSGDSFRARGTAQTNIPSWVKSYAVCIPIFPTTDLACRVLVRSILCNLVNKKLVDECHVEYLIKSGRTKSGYVDLERVINNIDFYHTSIPRIGAIQLIEENMEERAYSEATDFGQKYASSLQIVESEYHSICRTRVMDNADVYAPLACIIKEDDANTESAVRYDAADTSNMCVEISKLLGNVRSLEKQFRKDHTELTRLRRKLATTNIVPCESYGPLSPCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2D9</accession>
    <name>A0A061D2D9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0200880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767117.1">
        <property type="nucleotide sequence ID" value="XM_012911663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2D9"/>
    <dbReference type="GeneID" id="24563472"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200880"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200880"/>
    <dbReference type="OMA" id="FFHSNTF"/>
    <dbReference type="OrthoDB" id="363348at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="116" mass="13514" checksum="521243957C6B9276" modified="2014-09-03" version="1">MVFYESYLLFSKHITNEEIAALVAHIGKLAASHHGLVLRTQSLGLRYTSHRVQKPRLGLFWYGKYYYVALAANPKVVPGLHKLYNSNEHVLRHMTQRMLYRTNLITSPYSHLYQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2J3</accession>
    <name>A0A061D2J3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0106010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766478.1">
        <property type="nucleotide sequence ID" value="XM_012911024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2J3"/>
    <dbReference type="STRING" id="5866.A0A061D2J3"/>
    <dbReference type="GeneID" id="24562833"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106010"/>
    <dbReference type="OMA" id="NDTSWAG"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="645" mass="72224" checksum="898BE09AADB6E52A" modified="2014-09-03" version="1">MLKYLAGKSPISFASSGFGYAEEEPVETPFGHLQSFLWYNGSAKGAGTPASLFKFSAKNRNATAQNLEQEFAERHLRSIKLILHPNVLKLLKVKQTDTGITIATERCYPLSLETVSTDPALGLAQIISALNFLHTKCHKTHCLVSPTGVVVRDDGSWCLTSFECTVDNDTSIHRVLAELKWHASWSNGWRMPSLANASASVRQLDQWGLGALMCWVHTLIAGQVDLCVLSRHDRDIYSLKRYAPANLHELIDQLMSPDHDVDLEAVLKTHPYFTENEGISAMSFATEFHIKNEEQMSAFFSQLPTKLTRIPNDIAVGFAKCWELYGAVSLIPSILESVVVICKSMLLEEFKVKVYPHISKLFKENDRAIRYSLLRLMPDLDPMLDENQVSDDLLEPLLIGFGDTASQIRDETVKAMVYVMKKIKKRQQQNAAMMLFKCVEDCEPTIRVNTIICFAKIIPFVQHELVEKVVPQVWRLGLSDTFLKSKLATLESISASHGFFGTKQKVEILLPLACNTLLDSEPQVRRMGFDTIHSILDSLKEHVAEGGNESFDSQWAGVNKTTTQHKPQHATHPMTLVPSVAQPGVPRNPGASLGMPGQRSQHQHQLLAASQERRLSASKETPLRPATHDVMDELEDFFDPFPPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2K2</accession>
    <name>A0A061D2K2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0111160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767004.1">
        <property type="nucleotide sequence ID" value="XM_012911550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2K2"/>
    <dbReference type="STRING" id="5866.A0A061D2K2"/>
    <dbReference type="GeneID" id="24563359"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111160"/>
    <dbReference type="OMA" id="FACGTEQ"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="385" mass="42818" checksum="A6B286C308F0233E" modified="2014-09-03" version="1">MLPCSHSIASSPSIGGFSDARFNQDRSCLAVSCAAGFRIYNCNPFSLACERDLSAHVGGGVRTVEMMYRCNIVAAVGDDSAAWNSSQTSRASAEWTRNVLLLWDDKECCEIARLMFNSSITNVKLSRHLLVVAVVDEVHVYHLHDMNLLDTYSTFYNPEGLCSLASNCDVDTVAFPSPTRGMIGMAYYHLDCSDGALLGREGKTILAHNSDITALGLSVDGLLLMSASRHGHFVRLWNAFSVQLLQEFRKVPGMGLIHLCVLSPDATILCTVSNRNAVLVYRVNPQSPRVRRDGRDESFASARRVSSAPTNGLDNFRLCLHIKLMRVRRLYTFYAWPFSRYYPEDMVVACTFLPTTNNLLLVLSNGHVHRLGVNYRLRLLADHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2Q8</accession>
    <name>A0A061D2Q8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767247.1">
        <property type="nucleotide sequence ID" value="XM_012911793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2Q8"/>
    <dbReference type="GeneID" id="24563602"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202180"/>
    <dbReference type="OrthoDB" id="365640at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="148" mass="15893" checksum="AF0ACFA1C9165164" modified="2014-09-03" version="1">MERAEDGAKLVPLRHRGFHRFAALHKNVMLGTESPSVGAPEKIRMCESAVLTKGAGGDIAESTESAPNQALSTYKADFVRYDLPTRRVESLAPQCGNRVPFRATTTYRMDYRIAVCSDDPVLPAGAGPRPSAVEGAALPRRGPFGAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2R9</accession>
    <name>A0A061D2R9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0202280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767257.1">
        <property type="nucleotide sequence ID" value="XM_012911803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2R9"/>
    <dbReference type="STRING" id="5866.A0A061D2R9"/>
    <dbReference type="GeneID" id="24563612"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202280"/>
    <dbReference type="OMA" id="NNNILCC"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="525" mass="56584" checksum="C018184B2614FE25" modified="2014-09-03" version="1">MSTSGGAVSALDALKDGEDVLLDEDAGLPCLRASSLVCNLGGSRLLYGSSDGELRCLDFFKWMSGGCGPLWTQKLDQGITAVAMSSDDAVVAAASGNVVSFYSDVGDHLVNTSKGDMYLLDARKTHGHTAMVTCVCPQPLHSNQFTSGAIDGTIRTFDVESPRQGVAMSINSCRTYVPRAARGPRAPIRSLCYSQFNSSFIVIGGTDRGGILTWDQRTGNPASCCMDAHTSAVSCVASIDDGTLVSRDNDVVKLWDVRKFKSAVKECAVPGGDCGGGMAVSPGGTHVAVGEVTPVNPRNIKEGFKGCVRVLCTVTLDVVETFRLKAAPGPMCWAYDSAQLFTACNDGRTWCRGSSEAIEAMHLSRARATMRQKRAESVGTTVSVQPEAYPIDQLPDNLEEAEDGTLKRRRVPRQYKKPGAREEPDLDYVSYGRTPVSYEDEDIVKKLRAMDGESDKVSAAATGSGVQRIPYKADKFMRMYKKTQPDLILDFTAPGTKEESMLQGVQKCPRCGIKICQCGYMDSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D303</accession>
    <name>A0A061D303_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0107750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766663.1">
        <property type="nucleotide sequence ID" value="XM_012911209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D303"/>
    <dbReference type="GeneID" id="24563018"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107750"/>
    <dbReference type="OrthoDB" id="10465405at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="393" mass="43597" checksum="2186EEFEC7E2000A" modified="2014-09-03" version="1">MGVPSVHCEDKPQGLRVLVAHWKRFFLNRSKSGILKDLDCQYREEEGVPILSAAEQDRVGEVTDSVQQGDALTPQTDVGSNAAGDGDLSVDVKALNETLPEEGAQCIEMVELSSENTVATGEVTSLGIDEESVDSVDNAGKQLVASCHIKSEEENAPPEEDLLERESVESYDYTRTEDSMTEVSYCSADDTSIEGVARNDDSGDSLVSSASSFESDWQPRKVKKRVNPALQSKGCFGFTLIIALSRLFWRLHRRPARRVRSVMRDKITPMTSGVVLNIASVDEYEGRRSRCQTARKRPYVQHRRQLDASTSSAQSDDSRGNWTSISNADSGEVEGNGLLAKLIHKKDQMKYALEDYRRKIKLLQRQVNHNSGVGLAYNISRSRVLYDLDEAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D337</accession>
    <name>A0A061D337_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766698.1">
        <property type="nucleotide sequence ID" value="XM_012911244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D337"/>
    <dbReference type="GeneID" id="24563053"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108100"/>
    <dbReference type="OrthoDB" id="363615at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="154" mass="17388" checksum="88BA4EF4CE4DBB4C" modified="2014-09-03" version="1">MDYAVYAVLATGVVITLGIFTKTALWNHYGERVLSLPHPFLARLGVRRETTEWLVGLCCVLLSLNHAARGVDALGGYKSAAEVLLDLGKFAEDANAAQLREVFAGALGAMVWAFILHFYHKQRTSHRRVLEHQRKHEDDHITNNCLRFRQAFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3L4</accession>
    <name>A0A061D3L4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0109650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766853.1">
        <property type="nucleotide sequence ID" value="XM_012911399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3L4"/>
    <dbReference type="GeneID" id="24563208"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109650"/>
    <dbReference type="OrthoDB" id="366245at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="30117" checksum="7344229AC585B01B" modified="2014-09-03" version="1">MKLIITGNINGIMNFDECLQVISQSKKYAGTMVYVETVRSSLLDATGNAAGVILHNRAFHDQSMVFLRRLAEDFLNSAETEELLKRKVEQLLLSSGEVLRDTVIRLLHHDEVTKTAYAFSRQITEDLCKDEEVIEYVGQLLLDAINTKTAVDGAAKWFVDIAARDDTVEAIERLLCERVLSNANVHAEALDLNARITNVQCKSVTSQFLSAESTKRESVAFIKSVQDRPSIHAHLSQALIEVLKQSFYPRWPIFTTWEFNGATGLWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3R2</accession>
    <name>A0A061D3R2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Snf2-related chromatin remodeling factor SRCAP, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0110050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766893.1">
        <property type="nucleotide sequence ID" value="XM_012911439.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D3R2"/>
    <dbReference type="GeneID" id="24563248"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110050"/>
    <dbReference type="OMA" id="ELYDNNH"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="846"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1565"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="552"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1851"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1877" mass="212024" checksum="27BA0D7279E601EE" modified="2014-09-03" version="1">MQNMGAQVVNYTSPGDINAAQLGDQSANAMVPRQSQLSQMTVPGVHGSQLVAPYAVSNVVHLPAAAVAAGHVVLMGYGAHPVPTYPLGVGEAYPQLAQFDSQNSTRRFGSTSIEGDAAYVNMPLGAQYPQPEAPLGIAPTMPNASKESTPRIASLPESPSAEAAVSSPNAASIAAQPQGDTNPLPPQHRDAPQEPTPDCASSELDHARHLRKVKVRRHASSESSDSLAPLPFPSGKAGAAKWWGIKVNIEEEFRRLLPHMPQNTDELIAMAKPHVDIELSFFTELGGIYKEFEDETAMITENLDTLRKQLNELHILMGRTVPSKLTEPIKIHDLSIWEPVLKEMNDFQDLVDYEHREKRRKFKAISAAAQKQASKFENRKMALELDEIKQRKQQCKTVANAIAIYWKKIERFAWERMKRDLQATLIEKKRMRLDKFVEDAIKLSITKNDKVRADGKMKRESHDIKRQHTDEVTDEPASSVKTADHGEPRTDYVKEEFVKVERRDAGSPSTASDTTRDDGATKGVADDEFVISEEMKRMERDDALLDMAMEKEEQLDEAAGSQTKELNALEDDLNLPIEEILRRYREEEEKFKEEHDISSHSEADDGTEMSSSEHSDNELRSEEENDGGDEMDVDDEDGSEDETDSEDEKGDKELVPPQSLAATRSKRHRPESFTATPDAAKGESREDTKSGSQEGGKDDMEAEFTLGDDRFKEQEDEDLHLDEAISDEHSDNETGKQERVKEISALEEDANLPIEELIARYRATGGYGESSDDMSVEETESQTASDSEGDDAKTVDGSKEDEFSGEAERDDSTAESSADDEDAVQVPSLIRATLRPYQIDGLRWLASLYRKGSNGILADEMGLGKTLQTIALLAHLACDHGNWGPHLIVVPTSVLLNWEMEFKKFCPGFMIVSYYGSPAERAKKRIGWNKEHAFNVCIASYATVVQDSYILKRKSWVYMVLDEAQNIKNFHSKRWQTLLTFNTEGRILLTGTPLQNSLQELWSLMHFILPDVFTSHSEFKEWFSDPLTESIEREQMNGEGNQQDLQTSHLVQKLHTVLRPYLLRRLKKDVEKQMPSKYEHVIKCYLSRRQRVLYDEFISSRSAVEALKNPNYRSMLFVLMQLRKICNHPDQLQSRPVETPYYDPAMMENVAFPMMFLLPELRRGARLYHHDVIDMRVHPSETLPIMVGARGHQDRVVLPPSFVRSFRGSKVQFQRVFRQNNNAYDGDVAQLPVVSRFPISKCLLSRKSGGRRKLTLSGFLVEHMLSGNPFEDIRRRHMRCSPTRRASVGREYDQTLGPSISITASSCAFSESDATSTNFGFHDRFQQVGNGIVAMALDSGRSVSTSSPANAVMQDIDPFVNIPTPPHHAGPMMHNMDYFLPTSDISDVSDFATESNYVVCTTDDATHDVDPTVMHEPKYFARQIDDSNVVVNKRELLEVNDSFLLNKFTIDRRPKPKAEFFQKIIAPTVDDVVERNWWMLSRFVCTTGKVVECNPRRVVMVGQGGVAWNCRQEATAQRIHSKLQRPSSFRYFKETKCSIEHARGLQKVLFPPRSLLHDDCGKFLVLGRLLKRLKSEGHRCLLYTQFSKMLDILENWINFMGFTYVRLDGSTKVDMRQRIVTKFNENEKIFLFISSTRAGGVGLTLTGADTVIFYDTDWNPAMDRQAMDRCHRIGQTREVNVYRLISEHTVEENIWRKQLQKRRLDDIVVDKGNFDSEHHNWFSNVDTLMTILKQQTAEGRENATDDDDIYGKKVLHESQAPEMDAAIGHHGPPPRVVNMLVEAEDEDDANALKNRSKEARSANKDFQDFSGDMISSMPALVAYSIQLLLNYLTPTLIAQRDEMKVKIKVESMDSAVEEDSESSASEVGYGYDSESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3U6</accession>
    <name>A0A061D3U6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766918.1">
        <property type="nucleotide sequence ID" value="XM_012911464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3U6"/>
    <dbReference type="GeneID" id="24563273"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110300"/>
    <dbReference type="OrthoDB" id="365400at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21958" checksum="320643AFF9348226" modified="2014-09-03" version="1">MRRPCALLEIREKMGLQMDRDHLVRLLDELVAQGHLRCKKYPSNQIYIYNFSDQQEPTPIGAAKVRKPTKAALEKNAAQLRAAIEKITKKLQETQQLCNELAVLQERQKAALDEWHVLLKAEGDPRAMARACGGEVQRMMDAQVKRRAELGRLQRLYTHMVTAVSEIEGVHPRQLCERLGIEMTRVQLKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3W9</accession>
    <name>A0A061D3W9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L7Ae-related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0204210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767449.1">
        <property type="nucleotide sequence ID" value="XM_012911995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3W9"/>
    <dbReference type="STRING" id="5866.A0A061D3W9"/>
    <dbReference type="GeneID" id="24563804"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204210"/>
    <dbReference type="OMA" id="PIDIICH"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="179" mass="20011" checksum="DF814D8CF806CBF4" modified="2014-09-03" version="1">MSDTEDVVMDSSAEEPVHISPIANPLLRGKTLKRSLKLVKRALALEKLAKAKRLEEEGEADTILTRLVKRGVQDVTKAIRKGIQGVVLVACDVHPIDVVAHLPIMCEDASVAYAYVSSKRVMSQVCQSKRPTCVVLVTKPPKDLLQRLTKLVPDRNEKLNYTDLYEKVDRAIRNSHPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D467</accession>
    <name>A0A061D467_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal L39 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0205260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767554.1">
        <property type="nucleotide sequence ID" value="XM_012912100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D467"/>
    <dbReference type="STRING" id="5866.A0A061D467"/>
    <dbReference type="GeneID" id="24563909"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205260"/>
    <dbReference type="OMA" id="RRTKMNI"/>
    <dbReference type="OrthoDB" id="444696at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR95368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="51" mass="6351" checksum="4C5D69444437C804" modified="2014-09-03" version="1">MGALKSTTLKRHLGKKMKQNRPLPHWFRLKTDNKIRYNAKRRYWRRTKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D473</accession>
    <name>A0A061D473_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0111400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767028.1">
        <property type="nucleotide sequence ID" value="XM_012911574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D473"/>
    <dbReference type="GeneID" id="24563383"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111400"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111400"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="168" mass="18305" checksum="400F87BF46E8CAF0" modified="2014-09-03" version="1">MAGLMIFACECGTECKMVTWCYCCPWCCGKCMNGGGCRACKAHYIKRTTGQWTNDCYNLICEKQCRGKEKTCPCKCCREKCARREIPACSAASSPDAVSSPGSPGSPGPATPPRAQHNSATQQHTTGSSSPAVLPIIIAAVALIIVVICVMIYFRIRPFHRVRYLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4I7</accession>
    <name>A0A061D4I7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766035.1">
        <property type="nucleotide sequence ID" value="XM_012910581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4I7"/>
    <dbReference type="GeneID" id="24562390"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101780"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="25032" checksum="D7C04D0DFC34D578" modified="2014-09-03" version="1">MLLKFLDQPELGNQWFVGGLVKRYNDLINKSPGGLAKYFRVVDESDENVVKGKGITAGAIVENLGKVVHGTEIFLDDIKSPGEYESAYSPEAAWSKSCTQKPEDCAAVFVGIAPMLRASISSLNAAVFAAKLRLPPFIACKRMQQLIQALGYVEPQRRAGMSGFDVPKALRGLYLRTLITLCDFTGFWAFCGSNNPDLGAGKHGNYPVSEVDFDVNMKPIDASMKIGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4R4</accession>
    <name>A0A061D4R4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0201940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767223.1">
        <property type="nucleotide sequence ID" value="XM_012911769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4R4"/>
    <dbReference type="GeneID" id="24563578"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201940"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="114" mass="12630" checksum="674D1B4DDF86F156" modified="2014-09-03" version="1">MLGLGLGNHPAILAYSNTVWKRGQPKLKTSGVQGDNKTDDSLSLLRVVVESQGLKQSICRLKPYIKCSKQGIILQAMKCRDIHTQHHPLTHQSQTRQCAGFHSNRISQLISTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4V4</accession>
    <name>A0A061D4V4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0207530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767784.1">
        <property type="nucleotide sequence ID" value="XM_012912330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4V4"/>
    <dbReference type="STRING" id="5866.A0A061D4V4"/>
    <dbReference type="GeneID" id="24564139"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207530"/>
    <dbReference type="OMA" id="GIFFTCL"/>
    <dbReference type="OrthoDB" id="285735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="5">
        <location>
            <begin position="690"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR95598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="792" mass="84438" checksum="D26143183E5B59E4" modified="2014-09-03" version="1">MVDVPSNARRVSSQKRGRGGGAPRRPADRRSKEPAAAPSGKAAPVQPPAPAVERSDSAPAPTSLPAAGTGITTECFNNLLSNFTQALTASTPQAAVGDGQQTQLLCEMGKLFLSSMMTFNQIMQNHAASSLVTPQAAAPASTEPAVIPGGEVPESSAASSTAGAFKKQEPRVAGKGATRPQRTNAKPSVKPARRDSESSGTAKATKTGVDGSEAEVSGDATHPSVDATSGNAASVDGQKPHRKEQSSRQGDSRRRGDATHPCDKAQHPVPHNKRADALSGGDSKRPYGAQKGNRPSGKRDDTSTRYGSHAAGKNVGRRVGRADGNKHMSVATAVQSPSAVVAATDQETPKVDFNTAPTPINVIEGAEGAYLDGLVSAEEQLNFSIYRFVDSCTNANAAATERKVTVGVENPAGWVGEQPARECTTLTQTTDGTCSDAFPSGAVPNSIAEFMRAAFMGDLEQLKMQKDVDVSHVDDVGRSALHYASAAGSSACVEYLLASGVDVNLADRKGWTAIHIAVSKNFTDVAKILVDAGANIFTLLKHKCAPVRLMDVYSPAIHFAAIKGNKEITQLLLDHGATLNDLDSANMTPLHYAAFRANTDYLRFVLDNGAVVNVRDVNGRSPFHAAALSGLVENVKLMVERQPFLNEEDIWSLTPYKLAELRKHADFVTYLRETLHVSEEDPDDINRVLASTIAVALQEPNADQIYRCVTRIGADLSKTVFDLTMQIERNGGVLTADGSRKRTSGGIFFTCLRELYLNDIISKDDYNYIRAAENEKRIANAKDRRNLLKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4X0</accession>
    <name>A0A061D4X0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0103240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766190.1">
        <property type="nucleotide sequence ID" value="XM_012910736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4X0"/>
    <dbReference type="STRING" id="5866.A0A061D4X0"/>
    <dbReference type="GeneID" id="24562545"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103240"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103240"/>
    <dbReference type="OMA" id="RHWKPNA"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="59"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="8">
        <location>
            <begin position="306"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="348"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="443" mass="48765" checksum="6B81C4661452CCCB" modified="2014-09-03" version="1">MEGSNEMATNSDTEVRKPAGYAKELQMSDGSQDAVSETESGTTKAPLVWTKDIRPLKEDEVLEVAPGCYDMLHTINVDWPCLSFDIMADELGACRVQFPHQCYVVAGTQPDDRSKKEAAVHVMKWSNLSNNEGMELSEDESDDEDSACVLKCSSLRHPGIVNRIRCCPQSNRLVCTMADTGKAHIWDVDAHRARLDQEGSEHHMEKGKPVYTCELHEEEGYAVGWSPTTTGALATGDCAGAIVMWNPVDAGWSHLRYFNAPKSVEDIQWSPVDEHVFASACCDGYVRIHDARAPKDNVKVIRVCDGDITDVNSIAWNPSQTNLLATGDETGAGTVFDLRFSDVHMAKLSWHNQAITSIAWHPTDPAVCIASSRDDSVSIWDLSVESETAAEASDNGQNIPQQLMFLHMGQTEITEVMFHRQIPGVAISTSADGFNIFKCINID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D535</accession>
    <name>A0A061D535_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0103900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766265.1">
        <property type="nucleotide sequence ID" value="XM_012910811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D535"/>
    <dbReference type="GeneID" id="24562620"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103900"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103900"/>
    <dbReference type="OMA" id="YKRVEVP"/>
    <dbReference type="OrthoDB" id="360147at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="178" mass="20778" checksum="217C537F1A789F4E" modified="2014-09-03" version="1">MLRFSLLRRATRVPDALVMFGTHAERLPFVSHPGVMAVAQLLEMKSLVEHRAHFTQDDVNRMYEFDSSLAEKAQVAVDHDLPISHYNLEYLDKPGFLERLIEEKQLNESIASEVLSAPEGSYEQPESMSKYRAPEIPLEWRQHELALTHAMVDVQPSILREMETQRKMREFMERQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D567</accession>
    <name>A0A061D567_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-directed RNA polymerase II, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0209640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767997.1">
        <property type="nucleotide sequence ID" value="XM_012912543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D567"/>
    <dbReference type="STRING" id="5866.A0A061D567"/>
    <dbReference type="GeneID" id="24564352"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209640"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209640"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="19681" checksum="183DC570636E5310" modified="2014-09-03" version="1">MYFVVEQWKIINVKPSQLGPSYQQNIEEMLRNQVEGHCSSKYGYVVCVIRIIKNEIGRVQDGTGMIVVNVKYQAIVFKPFNDEVLDAVVTDVNKLGFFAQAGPLKAFVSRTAIQPSFVYDNDAANPCYSDGTISIKPQTEVRMRIQGIRYDNSNMFAIATVNADYLGAFENYSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5A6</accession>
    <name>A0A061D5A6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0208970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767929.1">
        <property type="nucleotide sequence ID" value="XM_012912475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5A6"/>
    <dbReference type="GeneID" id="24564284"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208970"/>
    <dbReference type="OMA" id="IYCLLYQ"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="557" mass="61390" checksum="FACCF6845A79A8BB" modified="2014-09-03" version="1">MGVGGDSELGGKEPVEGAGSTKVDRIKADYGIFGQVLYHVVSFTEGYEQQVLYLCMRIFESTMSFTKSQRTMLMTVSIMSRLCFSLVWGLLADAFETNLVMAAGLLFMGIASILLSATSRFSSILFLRFLHGAAFGCIYPVQQKIISDEDDEQSGNSSTFTRIHALNCIGRMLCAAITTEAAQNILLGFIGWRVSYIVLGYLWISVGIAIVFAMQTEKVLTTPYGSMDKFVKQISGSFSAVFSNWSSFLCIFTMLIAEAPMCTLPYMITYLEYLGVSDMKVGIAILVTTIGGAAGTAAGGIVIENITKMHPRYGELIAGIVVMGVRLIVCVLFFVSPAPDGRLMWYHYIEFAVLGATLVTVGGVDRPIMRKVIPDRYQASASAIIQCISGISVSVSFVEIFAYVSEKLHGYAPSTQAIDDMDAALKDNNTEALRKSTMYMIVVGSLLNIACYGALFATYEEDKKEIKKENVKVWVERKEIQAEKEKRKLSPKTENEVAITEADLQQTVRSEGRPKEVPVADPEGEMQWGEEPSRRESDEVPMTKEQQLEFIRKGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5L8</accession>
    <name>A0A061D5L8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768024.1">
        <property type="nucleotide sequence ID" value="XM_012912570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5L8"/>
    <dbReference type="GeneID" id="24564379"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209910"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="298" mass="32808" checksum="74228C212430638A" modified="2014-09-03" version="1">MAEVKNNKCECQPTVCHNYGDQPCDDPNCTKCRFGCPPGCKGCEKKCGDGKPCKCCTPRCGCENDCYEKDSKGPCKGKNGGKCKRCETKCKNSADGTCICHYCSCGTKCNGVICSCCNWCDPRNCNGGPCDGYVLGRCGAEGLKECKGHVKYDNYDAKGDYYGAVLKRETKNVITCDGNPHPGKECNGNNCNWIRGELQPDGYCVKFCTYCDKLCGQDNFRRCCTIAIPLVITVLAILIFRFMLPEKYHAITTKIRAVFPSSPRHPGRSLSNLVGDRIPEEMNVDRYPAVRPRAYAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5M8</accession>
    <name>A0A061D5M8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polyadenylate-binding protein</fullName>
            <shortName evidence="10">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BBBOND_0105680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766445.1">
        <property type="nucleotide sequence ID" value="XM_012910991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5M8"/>
    <dbReference type="STRING" id="5866.A0A061D5M8"/>
    <dbReference type="GeneID" id="24562800"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105680"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105680"/>
    <dbReference type="OMA" id="QQPGFMP"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000651">
        <property type="entry name" value="Poly(A) binding protein cytoplasmic 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="196"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="299"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="14">
        <location>
            <begin position="490"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDR94259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="566" mass="63106" checksum="00B00390DDDA7BDF" modified="2014-09-03" version="1">MPVGVFQGPSGRSSFTSASLYVGDLLPEVTEAMLYEVFNGVGPVASIRVCRDSVTRKSLGYAYVNYYNVQDAETALECLNYIDIKGHPARIMWSDRDPSLRKSGTGNIFVKNLDKAIDTKALYDTFSHFGTILSCKVAMDALGNSKGYGFVHYTTEESAKEAIEKVNGMLIGNSQVSVAPFVHRYEREATQSDAFTNLYVRNFPDTWTEDDLRETFSKYGEITSMLLKTDDKGRRFAFVNYSETSMAKAAMESENGVKLEGAEEPLLVCQHMGKARRYAMLKAQYDSSAQDHRNKFLGVNLYLKNLDDAIDDAALRDLFKQYGTVTSSKVMRDPNGVSRGFGFVCFSRPDEATKAVAGMHLKLVKNKPLYVGLAEKREQRASRLQQRSRQNELMQYGDRPSYMPLYPPDMPPHVYYNQVGFRPTMPAQPMTVAPRGMRMMAPVPIVHGRGAASPHALPQGRRATVKQVPLSGFKFTAQARNRTEMPNGAPSSPPPSQPAIDGAAMHKQMIGERLFPIVARENPDLAGKITGMMLEMDNQELMALLDNEQQLKDKIQEAMRVLQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5P0</accession>
    <name>A0A061D5P0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetcial protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0211830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768227.1">
        <property type="nucleotide sequence ID" value="XM_012912773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5P0"/>
    <dbReference type="STRING" id="5866.A0A061D5P0"/>
    <dbReference type="GeneID" id="24564582"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211830"/>
    <dbReference type="OMA" id="CIKYIGT"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR96041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="928" mass="104484" checksum="C8989AD3C3C1E242" modified="2014-09-03" version="1">MMPRTSSLLSDFSSPGSYLSGPMDESGPITSEGDDFSIIIPRNMQRTNSKSMLTDDHTFMLNLPMNMESTVVDLRSLSTEGLPSPSKFSIAKMLARNSMLEQAMQFTNTNGYRNLSHLGGRVMAQHDRHWERAMIQRDANMALQLEDCREANFADYVHYDPEEFEEASPTPSFSDEDSSEVRIGIPLRSCTLHAPKPRKRGVVEELVSRGVSPGEVAKLSDLFEYPSCLKAVDMSFIPWIKTQTEQGYWRNEAALFVLCVTMAISVGNVETLFKLNASWSGMVFLVPYFFAYILVVQPMICLELMLGQLYRGGQSAIYDKLRRGCSGLGTAIVVICLCSGCFACARCAAEYILYIFDIFKRQVPWKLAPEEITMCNEITDRDICMQKIPMCYFANDVCVPSALGKAYLAYQSKFYTATNEVLNFEPSLAWAIVGTYGIVSVFQFAGMGNFTFSASLVIIIAFFVTHIQVGSAECARHGAQAFTAITLDGGTDFLWESFRNLDWSHLYRSSRIWSHSLRSCMYEYIIGSGIYTTLAAKSRIGYDISKETVGVGIFSGYVTMLLFGTACALIGHYAKLLRLKPIDIMWMLGQDCSYILLPLGFKSTENMERTLCMLQFSCCVVMLCSTLAIQIEVAVANIKDLPWLGINKLHRRWTSLCIILVLMCSSLMLCSRTGKRVVWFLEIAVGDLGRAFTVFIASIVVGWLYGCDKQKEALGTKAVYTFNAVFWAFNFVAFLCETSDEYLWAIVWWFMRAAGIAVALAAAYHFNQQDPERSKTLSECAWWLCCGNVEQLRMEICRISPLSNVGGLPMKIFWSICIKWFVPCMMSNTIADVFEEIVAPHRVAVQVNKIPPGWQWVTILLWAFLICIVFVPPILLWVAPNLVPVYETIDLSSIPSCPVKHSFWQNLVPRNLFRELYCDNGRVKPKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5P2</accession>
    <name>A0A061D5P2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0210210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768054.1">
        <property type="nucleotide sequence ID" value="XM_012912600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5P2"/>
    <dbReference type="GeneID" id="24564409"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210210"/>
    <dbReference type="OMA" id="TSKIHED"/>
    <dbReference type="OrthoDB" id="365658at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="658" mass="72424" checksum="6E5B3DF2DEE546EA" modified="2014-09-03" version="1">MGSRAARSLSNEWSGFCATFTSAQLSKVLNRIALNFGRLSQSTNFRREQCLKSFLEDHVLRSLSPTLRLEGQGQLGFEAVLQPLHQRVLLLGRSGSLRSKDASLVLNAYAKVYQCTSQPQATSKAQWDIVSRKLRWCAEQLLPVARRLVTDMNEQDLSLVLNCVSKLGLSADDLLNAANDALANNLVAHYRAESQSGNDPGAPETGRNVISQLTPQGASLVVNSFAKSDVALNDAVLNHIVHRFLPSHLEQFLPQQLAVLLHGFLKYSVPAKDLYGALKHLDRSMSIAPVESNPKLLSSALYTFGKYNYLPAELVRQMETVKGGKPLRLSELELSNICYGMGKLRIRCEPFLEKLTVAMSRVLRELTPQGLSTVYYALSRLDIRDTTRGITRNSTRDSVQTAIIRRFEELVELDRKSARYAYVNRNISQQVLPLHIANVCFSAATSLIVDGGLFARLLRHLTLCFTRLHVTPHSYARNFNAAPGNGGYIEHGTQGVAFDAFALTGESANIDVAATTDDRACTFLTTALGTQGTYQLFCICQHIAGYAAGGLSALGLEELKLLAELFSAWERISRDKPSAFLSEDPCRSVVLVDPDITTSKIQSGVFAVLKAMLSRSPETREGRHDSGLDDQCSDGKETIVVAESHATPYAIDILLYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5U0</accession>
    <name>A0A061D5U0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0205350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767563.1">
        <property type="nucleotide sequence ID" value="XM_012912109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5U0"/>
    <dbReference type="STRING" id="5866.A0A061D5U0"/>
    <dbReference type="GeneID" id="24563918"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205350"/>
    <dbReference type="OMA" id="DTEVITM"/>
    <dbReference type="OrthoDB" id="343108at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="548" mass="61920" checksum="5915C799C241BB3E" modified="2014-09-03" version="1">MNEFIIGLVSRLADSDIRVVTKCVPWTPIKICHGTAASGYNCINIHQEYFAKIDGKSLPGFVVVGRAVNQYFFQSKIAQTSAADIWLCFDVTTNSFCCIKAYSIESCRRQNALRFCAAEMEVVSLLDKVIDEVLYHSSVTGHPGVSTLREVIISVDRDVFYIVMDYYPCQLLHFHSKLNTYVAMTSTNHVAYDQGESCMIRLYKEDHARRIMKDIIGTVIYLHSVGIVHKDLKPENILLLQDDTSMYEAVNISYICDEHQFDESSLIDENESYNPYCNEILGEYVERFLLSEVTTSCYEIELSHVVEMHFPYDNSVASDSEWLWDNGCDIVCDIIQGSKEESKTMRIGKAALHFAKTTAESCMHNSCNLLDFFLSASDSYIPYKKPELLLSAAESWRGQRFRTNQKALIQRSVVEIRDVCVVITDFGVSSIGDVDVANGQPLLYDGEGTTSFCSPESLQYVEGPISGSKREIFSLGVILYAMIYGVLPHEGNSCIETLINMLEKPLIFHNYRPVSPDLKDLLKGMLNKDPKQRLSTESILAHPWFEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D611</accession>
    <name>A0A061D611_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 15">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BBBOND_0300510</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 15"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768332.1">
        <property type="nucleotide sequence ID" value="XM_012912878.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D611"/>
    <dbReference type="GeneID" id="24564687"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300510"/>
    <dbReference type="OMA" id="CACTREN"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1732"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1405"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1414"/>
            <end position="1423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR96146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1788" mass="200786" checksum="A4435CA6386B00D1" modified="2014-09-03" version="1">MTRKGKKQEERKVRSSDFAMYQTANSRPTGLHHIFDSFYHDATAYGTGDQSRDGRSDDASSAFSQSQAELLKALEKLTKKDGTTKLKAIEHLISLLDDTPDYVLEGLVPDFMHLFKRIAVVEPSRKIRLHLGQALSRIAKTLKKRMQVHMDGIVTYWWMAMHDDAPDVASAYIEAFHSLFSAPDAERTELDRKTFRVLTHYIQTIANTSLMLLSRNIEEYKRDWMDTFGKTCDNSATISDMHNRLVCSLLQGIVNLMTQQRLFANEVDGDKLPVTVFVNDELVNRIGSLCLNGTFRQRLASARLLVELVKVLPAGKLPIARKLFGIGMKRVHEDEEAHISYQHVRLICACARYNSACWEPSILGNYASFVKRVLEQHTGDSAVTAELYSLCPCLVSYLPQEWLRSPSGEQAVLEVIKYVLHLLSEKLQANYEKSYAYDVKMLSQVGSSMLYCYYRILMLLEGNCETIAQHAIAPILELPYESTSLAKHLLSQLPRIFTEFIEEAEAMKSSEAIDTILTMLRKVDEKQVNGVLMTRIFDSLSKGGHNDVEDVEPRDSIKSYVRNAQKGLKSRIMEDELPSVLMEFLAEPQSPSCVERMDEMLSVADSITTLSKDSGILVAPRFFMERKYHDSWEFEGAFAKLSRVLKLFEPLLNEPEKYYPEETDAKSVLLVSLVALQNTDSDDKAVNIAKKVYSCLTELGDGNCLAVFLKFVNASQRFSHCLSQTMLGWLMQPEHLNVATCEAVYSAVDVSSLDAEGLLKYELLHTVLRFERKTAVKGYKPKEHGMVDDVVAFYLVGYYTNLLVRIDTLLNFSVALLPEWQQGKSTADSDRLKSFLQLLQRGKDTFKYSHDTSSEVVLNKDLVNAMISLQSTPCRCTVSISRTISALTQASVLVDAVIHHRNAVLFAQLWYMNCEAYLFVADETSKLHRDTEAVNGTATQSDDDTAKGDEVAASKIHGDKVDLQNFASVLVPTLVNDGFNYPLFEKLVEKVLKSCACSDTITTTLVKYICSKTWKSKFEYTNKIQLFNSYLHKLGAYDESVVALFKQQYCSNQFVGGFVATSKRMGNVAITTADDILSAVELCGEDDIVLMTNYLLELAPLFGNSFVNGDGKFDVKEGCDVSYLTEKMVSVPLAVLGKLRILKHKDACTSFWLHSALLDLFHACSCLVKALSLDSAAFLKFVEGGWIMSALSFCCRNLSAPSHLVINLFAEIMHLCISNEIVSLKVLRVDRGAYDFSLSSLREYADVMEALSAENVAQALAEGPFGTTVDSIDPHYFVSMVVYFVESVDSQKTVVGHDADDIQRALKTLKAATYEFVSFLSKSQSCYIYSLAFVSRLWCCSFLFSHIAEYSGTLCNVDLEHNSVYLLLPGKFAAVETSPDVHNAVNQEGVPIDISQLLLNALQDPEENGHPGDAEEPSTDNPEEVPVGPTREEIAYFGRKAISFYFNVLFGPHITGALFKTYDVFGDSCHHQDLELCLTSWLSAFMLLQHLVESNQLTLKNAILKVLTANPSEAGGAMYESIKAQVSNAVADEGKEYVSAWWLSDAPAIPEHADESALHVLLNVLILCLENLYLKEERYRHLVKTLYYKVSKVFPEEVNHVWNQCKSVYVKKQIKKFTKTEITQRLIADELRALKACKSSALHITHDADYRNLYASLDTKAEVSIKLTVKIPKAFPLEPLSFTSTEDAATFKNKHLRWLMMAQSAANRGGISQGLLLWSDNITKFFDGIEECPICYSIVHLQFNSIPGKTCKVCKHKFHTECLYKWFRNAQKAKCPLCQSTSSFTSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D641</accession>
    <name>A0A061D641_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPLICING FACTOR U2AF-ASSOCIATED PROTEIN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0106980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766575.1">
        <property type="nucleotide sequence ID" value="XM_012911121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D641"/>
    <dbReference type="STRING" id="5866.A0A061D641"/>
    <dbReference type="GeneID" id="24562930"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106980"/>
    <dbReference type="OMA" id="WEHEAGS"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="389" mass="43528" checksum="81463C7DA6CEE359" modified="2014-09-03" version="1">MDAWSAISSVDELKSLLDGEAKDSSASKEAESSRPEVAVADAEAALEAADTSATVAAEAAPADDATTAVSAEEEARIRKREKKRQYMQRKRMKIESGKWVESAVGVSGGVKEPHQRNLSVYVSNLPDDTTAAEVAQVFRRAGVIKIDPLTTLPKIKLYTDDAGRFKNDARVTFVNKESVDFAIRYLDNYHFREDCVIHVEAARYDPQKYSAKSTVPLSAEEMRKRYLAAKYEQERLQSWTEDIDDGSGRRIVICKPMFSQEDAWEHEAGSKFYDDLREEVAAEVTKFVPFDKITPIPRHPQGVVCVKLKNSADAEIFISKFQDRVFDGQRLQVYFFDGKTDLQAQALPSKTAAENFFAAVKSAPPSYDSVACDWIDDQSSDEEFEVQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D678</accession>
    <name>A0A061D678_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0212050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768249.1">
        <property type="nucleotide sequence ID" value="XM_012912795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D678"/>
    <dbReference type="STRING" id="5866.A0A061D678"/>
    <dbReference type="GeneID" id="24564604"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212050"/>
    <dbReference type="OMA" id="VPFHRVM"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="169" mass="18442" checksum="A2C05C09901B2ABE" modified="2014-09-03" version="1">MAVTLHTSHGDIKLELHCRETPKTCKNFLALCASDYYTGLTFHRNIKGFLVQGGDPTGKGKGGESIYGGLFEDEIVGHLKHDKRGVVSMANLGKPNTNGSQFFITYAKQPQLNGAYTVFGRVIDGMDALAKMESEPVGEKYRPTNPITIQKVTIHANPIAESEASEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D695</accession>
    <name>A0A061D695_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0212200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768264.1">
        <property type="nucleotide sequence ID" value="XM_012912810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D695"/>
    <dbReference type="STRING" id="5866.A0A061D695"/>
    <dbReference type="GeneID" id="24564619"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212200"/>
    <dbReference type="OMA" id="IRTQMCW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="385"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR96078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="480" mass="52622" checksum="8709D936325F6502" modified="2014-09-03" version="1">MVDTFDSVRVHLKMSVANDRVKEDAKALGVTAVVLAAGSCDNLLPLTNATPKALIKVGHRSLICGTIDNLVAAGIYTIHIIVSVDDQKCIEDHVRSEFAAEGTYGTRNGGNDKLDISLHPIVDRDELISTTTDVLRYASELMETDFMVVPCDLFGTLNIRGLVESHLSTKRLCTVALLEEKSNPQETKKTKQTPDDQIAPGGDPVKGWGYKYRVMATMDADNSQLLGIADLLTINSGETYAVDKWTARRHPRCVIRNDLYDAHIYVFSKHIRAIAELPCMEHTSIRLDLIPHIVKMQEVPDAATWPSRETTSNGTQEERVYVKDIEQNDASDAMRVFHYMDIGDSTKCGRVNSLEALMNVNMQKAVEGAQKQAGQAAQAAGVKMRDVIIATGCNIGEGTNARGCVMGENVTIGKNCKLSKCVIMNDVTLQDNVNLDRCIIGQGATVSTKATLKHVVVAPDHTVPNNTRVERDFLPSFIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6H6</accession>
    <name>A0A061D6H6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Flap endonuclease 1</fullName>
            <shortName evidence="16">FEN-1</shortName>
            <ecNumber evidence="16">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BBBOND_0300630</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA1 and PCNA2. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="16">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="16"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768344.1">
        <property type="nucleotide sequence ID" value="XM_012912890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6H6"/>
    <dbReference type="STRING" id="5866.A0A061D6H6"/>
    <dbReference type="GeneID" id="24564699"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300630"/>
    <dbReference type="OMA" id="INFREAR"/>
    <dbReference type="OrthoDB" id="361602at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exonuclease" evidence="18">
        <location>
            <begin position="28"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="19">
        <location>
            <begin position="148"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDR96158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="671" mass="75383" checksum="480913432C173ACA" modified="2014-09-03" version="1">MGIKGLIGFLNEFAPGSLSNVTLDSVSGYTVAIDASTALYQFTIAIRESSYFSSLTNSKGESTSHLAGLMTRTIRLLESGIKPIFVFDSTPPEAKLQTLAKRKELRQEAEASLELAKENDDKENIKKFVGRTVHISKSENESAKELLRLMGIPVIEAKEEAEAQCAYLVKQGLADAVGTEDADALVFGCVTLLKNLTASNKKILKVELAKVLELLNLTHAEFIDFCILCGCDYCGTIKGVGPKTAYNLIRKFKSIERILEVKSESLEGYEVAQEYFRNPQVNHIAEIPRSEPDLTALKEFLVDKNDFAEERVNKFLERLLKAKTKKVQLSLRTFFTKPSVPQTASLSTSCSIDDSEGVPEIQEPPESAPLLTTCRIEDNESIPVTKEAPEEDDKHVKRVEKPSMGLLSVCPSHVRAVKKRHVRRFEKPVPIDVDEETVPEHLKRFICVRHFEPRVTIKRTSPREVDAESVEALVSHLCGAHGVARKDAVTPEEECAMSGEGLLWPNPLLQNLRASTGNLSNPRLRDLWQSSSSHGISWDALDKLYMSFREARDSSIAEWDKHAPEVADFASKVARDKITRWCKDSNACPPRLLRMWTHLLYTRWRERYLHIYSTRMLSRFLKGEITDRVLMRELNECTGSDTHCSELPFTTKASEHNPHFVHRVAKGVSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6J7</accession>
    <name>A0A061D6J7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FHA domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0207960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767828.1">
        <property type="nucleotide sequence ID" value="XM_012912374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6J7"/>
    <dbReference type="STRING" id="5866.A0A061D6J7"/>
    <dbReference type="GeneID" id="24564183"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207960"/>
    <dbReference type="OMA" id="RVCTRTW"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210:SF1">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="155"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="278"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="634" mass="70491" checksum="98D8ECA50B909E07" modified="2014-09-03" version="1">MLRVCTRTWTRDSHDLFDYETQDPKQLAERHFAASNSFRLLRTESTVSPVTALSQTDATNGERERDHLLSVFCRRPGEYTLAPAERVPGQSLIPQRLWLVVRALPNKRYALQEHDVIKLGRYRLRVKKIVPKNALAGFDVSTLLDFPVPELELPVPDGSMMQCRICLSESTDDDKLLCPCECKGSIKYVHAECMRRWIHLRAMKDSKESDQPLKAALLCESTCELCKARLPPFVRVKGELIPLVMMPNMSCPFILLENVTPHANKGMHFISVQDSDFVRLGRGHDASVRIADVSISRNHATILYENDTFYLEDHDSKFGTLVALRRPTPITASETVAVQVGRSLIELTVDPTIKFAAGCVDIPPVLGSFNFCNMMSLPVVMSESATPVVSMMETTPVGSTPQNTDESMGTTGDVYSQEFMMHFGGSSPMSREGGESVHTLSSGRRSSPVFLPETNQEMPSEEASTLQSSFDLDSLFGRQQWDSMYGEDTNSHMMYGSHVEEPCPGSTNDGIAYLRLILNTPSRNHILRNLRYHNRTNPQNRIIQQTEAPCFPSQNQGVGFPVTQMEEPSANACFLPDNAFMNLDGAREASGSDTSTSALDGNHSNSSQVTENVHNVAQWMPLGPGSGAQMHQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6K8</accession>
    <name>A0A061D6K8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768379.1">
        <property type="nucleotide sequence ID" value="XM_012912925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6K8"/>
    <dbReference type="GeneID" id="24564734"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300980"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300980"/>
    <dbReference type="OMA" id="GICHAES"/>
    <dbReference type="OrthoDB" id="366312at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="274" mass="30318" checksum="938A9CDA9B5976C0" modified="2014-09-03" version="1">MGGNECAKPSSIGLSIKSDASTSNTDRNLFPRYLMTDQFECHLTSDDLTIVQDAWSYIEIACRSATPLEYALGICQAKSVDYVCQLIPPLLDGMLSELEAEIIPAMLNKTMLICHKNGCTPEAIKRLHSSMFSLLGNKKTIRMLSPISFSTLIGVLNRVEHVHAEKVLNLMIECCVERMSSTTEDGPTVHLHCNNAFKLLSVCVKKSRVDATHLAKGICSNAHHLEKERVPQLLHLLTKMGFKDGRYISMLEPIAEKAMAANSDTARILKLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6L3</accession>
    <name>A0A061D6L3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768384.1">
        <property type="nucleotide sequence ID" value="XM_012912930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6L3"/>
    <dbReference type="STRING" id="5866.A0A061D6L3"/>
    <dbReference type="GeneID" id="24564739"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301030"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301030"/>
    <dbReference type="OMA" id="ETICATQ"/>
    <dbReference type="OrthoDB" id="10589489at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111750" checksum="ADFF76ABF14512C8" modified="2014-09-03" version="1">MFQHGPQVEFTSDVQSDHNIHIEVSNAHDLLFVAQNASVYIYQLTAFVSSAVANEPYDAHLLDRITFEDAIKRIRILHEWHLIACLLAHKVVVYDFSQGKKRFESEFTVVLECVYWSGKNLLVRDADSVLHMISVDGTKKSILRDCKSISPAGSDGFHLVCQFNGSLSIQIFKEYPDPSKFVTLQLPPLYEASQITDVVGSHVISGDLVAIGLVIDIQDSLILLCRYTSSEATVVHWAFNELFLTVDDIYPQIEFVWVDEWQCLFAWSNAATMVVVISRHVKLVGDSTWHVVNMKEGYCLESVDIDCCPTDLVVCTSYRDKLYRKNASADAPLLTDPTVFMLAQGASKIALHYADTWLIDKDLKEVEQLPRLRRDTDGSLFSSFVASRCSDENVVNKKSIIHHTSDMPEGAHLDDMFACMKVEHTSSSYDKNLRPGSTGLGHTQATHGGQKSVELSTNPDTANCHRFTDSRSSSNVVSSKIGQPQALDPLAAVDEVYHSSIKAYAQLPAEKERHLERIRLLEMLCNCFHIFESRLEDLESTISSEVATPRGVKMDDWASSLEDVKSIYNEIIRNVSGATGDYSNGSIDVLSDDIKKMYEETMQSYTSKFHIYGPEVDLKDMEHHLDATKGVLISLNDKLDAYENEISAAENNRLFSHKAETTMRRDSCIRQRTRESKMTDISDLIKKLKDVHIKHAPNPDIEYKEVKMKFNEYGTLSKLKSSETICATQIVFTQEARPRGCDLLYSKNYLETGSIRTHNFSTTNETTGTSIEITTNDFRKDGRHNPSDSSTSSATGTHSKDGTSTAVIQPKDALSNVVASGNTEGMSVGSYNTVAEVSSLDASSSSTADNTRLGLSTTALSSSSIPGGAIHQVQTYKFGDTGDMAKCTLSSACFAPVAAPSGPAPFALYATNSPTSFADLALSKSAGKSMFNDIQKEPNQLFGEGPLTGTIPSFTGVRGFTSGNFQATGLQNASPVFNYSSNPLRSGLNTDDKAPIAKSGGDIWGSFRRSNPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6M0</accession>
    <name>A0A061D6M0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767853.1">
        <property type="nucleotide sequence ID" value="XM_012912399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6M0"/>
    <dbReference type="GeneID" id="24564208"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208210"/>
    <dbReference type="OMA" id="YFWKQIC"/>
    <dbReference type="OrthoDB" id="364499at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="73539" checksum="69691D0488592983" modified="2014-09-03" version="1">MADVGTPFHILRKTRFTQCRTAYNTVRNALLGLQNRPLYVAEPFELHRNKRRLIAIKKAVSARRNSKKGPFHRLLPPHPYSNLFGDPTYYSNDELCRTCVMASTMRLGDRTFWWQIGEKIRKVRDVINIGDLLRCLVSLATVKYFDADLLRITAREFVDEMDKLTLHEIAQLMQCYARANVYSVDLVNSAGDLVAGRLMEMVSGDIQADGPSDHANEGEDASKWPQATLGLLAKCFRFFNYHNRDLYLSIAYLTIKNWRNLDLYAKCATFANLDHRNFQSQPNHESNAASMECGEEISRDTTLALLRQLAHFPDGFHLKRLDSITDDVDFDAMVPSAPEDIQGDYVKALHALCCAVSAVNNLARVSCRVVDNAAFVRESMAAENVLPIIGSTMEKMAAILARSKVYWRELETAYKTMDLTQVAFASEGNTDEAPHKCIKTCPYINTAKHVLIDAAMKSLCAVNAAIRFKVNAVRAEGRPVSDSEFCFAVDDDNVHSELYHYVDSIKLTASEMAVVQHWMDIVETCGCSSQEPELLSCALETLAVLLCVDSQKSALSVERVQAIHDLLALEAVKHLVNIREDGRYRIMLALRLGKVAPNAYLEHALQRFTKCLRKNKCKVKLPLVSPYRVLLEEGTAHVLRSMRYAAESETQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6P5</accession>
    <name>A0A061D6P5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0301280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768409.1">
        <property type="nucleotide sequence ID" value="XM_012912955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6P5"/>
    <dbReference type="STRING" id="5866.A0A061D6P5"/>
    <dbReference type="GeneID" id="24564764"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301280"/>
    <dbReference type="OMA" id="KCENIVI"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR96223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="422" mass="48298" checksum="DD68994BB1ADF315" modified="2014-09-03" version="1">MKSGFLISDDPAVSKLSVTKSGNDATLGKRKYRFEDFELERNIGCGNFSQIWHVTLKARPQESYALKIVNVQERNAMLLLNSPGHPNVIRMIDTFRDNDNVYLLYEYAKGGELWEEIKNVGVQDKYVSRVMVGQLLNGIEYIHNRGIVHRDLKCENVVIDGGVLKIIDFGTSKFVEQRDVMEQNDEAYNECRDATSRSIIEKNEMRGNNGSISLHRGAMMRKKFKHYVGTPNFMPPEAISNISSDYAGDLWSFGCTIYQLLLGFNCFTGSSNYFIYKRIKINQIGFPANFDPDAMDLIKQLLRTNPQERLSLAKVREHKFFTAIRDLVPPVVSLETLKTVDTELRRACNEAQELIYNLTVKRENATEVDHKEIKDAISCIEQHDVPGISDAINFNYVRTQEQLALEIDEANLYMAERLPNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6X1</accession>
    <name>A0A061D6X1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane CLPTM1 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0109770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766865.1">
        <property type="nucleotide sequence ID" value="XM_012911411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6X1"/>
    <dbReference type="STRING" id="5866.A0A061D6X1"/>
    <dbReference type="GeneID" id="24563220"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0109770"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0109770"/>
    <dbReference type="OMA" id="FWVLEEH"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="590" mass="67367" checksum="2E37A8D1DFF4BE69" modified="2014-09-03" version="1">MTAAAEEQGRARPQRNWILQALFQVLTIHIIMSIFGGKQRNAVDPVTGKPAPALKNYLAAGELYDVFVYASPEPYLGVDSLESNAQLVYSAENRAYAHKFNRAYEVVEATVSAPSNFFDSEDSVLHAIVFLVPHRSYATRGSALHLSTFKEGFDGHVIVKSIPLTMMRPVKRSKEVSLVGGDAESAPEEDEGEDLRKHWVPRLDVNLVYETAPCIQRPGDVYFDKYDKHPAEGVYDPLMYLSQFWVLEEHYQCVSPEMAGAPLELKVHFSTCNSMYYIMTTQFKANAETGGILGHQSVKEFEMFKRTLMTTNIYMLIFSGAFILLHSVFSFFALKNDIQFWHKNDSMEGLSALSVLISFVCDVIIALYVFDSENVSWLILFEMGVGVAASAWKVSKAIKFKFKRQFPFVELGNANNYVESNTKKYDEQAIKYMSMVMIPCVVAYAIYSLFYEKYKSWYSYFISVAAGSVYTFGFIMMTPQIYINYKLKSVDHLPWRALIYKSLNTFVDDVASFLIEMPWMHRLSCFRDDIIFFCYLYQRWAYRVDPSRPSAWNHPEQEPQEVAEGAAAETSIENEPANADEDESAPTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6Z6</accession>
    <name>A0A061D6Z6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable ribosomal RNA small subunit methyltransferase mra1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0303850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768667.1">
        <property type="nucleotide sequence ID" value="XM_012913213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6Z6"/>
    <dbReference type="STRING" id="5866.A0A061D6Z6"/>
    <dbReference type="GeneID" id="24565022"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303850"/>
    <dbReference type="OMA" id="AMSTCYK"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR96481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="293" mass="33580" checksum="E7A4DD2247A30052" modified="2014-09-03" version="1">MAINFVLCNASLELHRERSHKRRSLPQSFTLLNEEDHYREVATSKPSEQDADQNLEEEDVTEDSAASEGKFRRRNWKDVRPDILHFCLLALHDSILNKEGRMCIWVHTLNSQLYRFYPAFRIPRTFKVFNKVMAKYLHTNARCLKPEGDDATVLVERMDQRLEDLGEGGVKVAVSSRGRLQCAETFFADTVKDDLGNLWIYVSLSHYTPLPVPNESGILCVADLHKKYLDRANSTPVKPTYSQDLEDELLTEETTTSKPEPSFDHNISISTTYPTAMSTCYKLVCAIERALDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H4</accession>
    <name>A0A061D7H4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0111270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767015.1">
        <property type="nucleotide sequence ID" value="XM_012911561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7H4"/>
    <dbReference type="STRING" id="5866.A0A061D7H4"/>
    <dbReference type="GeneID" id="24563370"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111270"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR94829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="281" mass="31306" checksum="9708433DC25BF954" modified="2014-09-03" version="1">MTLTLVGLGLGAIQDITLRGLEAIKAADRVFLEIYTSALIDSSREELESFFGKPVIEADRISVEDQAEHIIQEARDKHVVLLVAGDPLSATTHCDLCMRAEHAGVQVDVIHNASIINAIGRTGLQLYRFGEVVSIPLFEKNWTPDSFYDKIAKNRRANLHTLCLLDIKVKERSVENLMANRMIFEPPRYMTVNVAIEQIQHVDAAKHEVDASTRAFGVARLGSKTAQIVAGTLEQLKSVDFGAPLHSLVICAPELHDIEEQYYQHYHCEKGRAQSQPKHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Q1</accession>
    <name>A0A061D7Q1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765931.1">
        <property type="nucleotide sequence ID" value="XM_012910477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24562286"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100740"/>
    <dbReference type="OMA" id="CLEEYLY"/>
    <dbReference type="OrthoDB" id="361423at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1498"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1603" mass="179375" checksum="DBEC2F49E99EC043" modified="2014-09-03" version="1">MIGPVAAACYGALLVCVVRFRYAYAYNRPSGIHHTELSRPPEWQDVGSKHSSLSQVSRKWSCGASARGTRDNAAGSQKQYVENDIIYTEFEPLHAAASGPSQYDLALHDAAKHFEEVDCSGGRDSSPRSRAQSTRIPYDEMQLAFFQGDEVVGEVLRNTQDVLNIACDHVTQLHKSRVYTGSGEESNRNSASALRSVRCLVYWIGGRILNCAKQAMDRLDRSSNASASETDHIRRIIEKQIRNFAHETMHQWESAIEVNEAALGPPKFHDIRQSRSPEEHVARLWDYLNVAAFGGMLPEFVDINFSWYDLVNSDGTVIPAEHGELFRYTRKDNIALPGIAYPRELADREAALGNCVFRSMLKLHCDIYGPKFGGDNYATVALAACQFVESEAARGARLGFSCVQADLIAYDATLRHLLPHLNSCDPLRNADAEVNDSDELYLGIDRLPFITNRLQFAHLKAVVKDLETSLDIFDRSFRPRGQASRDLVTDDVKRIAADIALSNGSSGTMAGVKRSAGDELMSNAVETSEQGASDEKVNGSSGGGHVDRARPDHEWDDDLDAIWSHDSEGNLILPIEELQRSLLFGDLEKFGNLLSLGMNDLMKLKPVQLNSIQNKVVAICLDTLNYIRSVDTYAINYSLAPEDLAREKPTGLVHQANMGVIQCILFLYKLVGRCLTHSGLFPLDNAFLRVRPLELLVREANPPSTGGQRVAADPARFGEETLHQEQKMKPVPFPQEYINEAVAADDPAALKFLVNYYNFNLFGGRLPIDIEVVFEHTAVDDYLSSHDDCADILKTPRILLNPLIRSSKPLVARLILEECYHLFLRFAYRYGSGFEGRSDVLLTEVMASDLAHRTRRHIANCIEGSGDWPFFFDDMHYMAVQEHTGLEEIVDNKLQLRNRTLNDVFKALMNTPSDVTRTLELLVKRPMMTDLWERQVLPLRHFVNALHGGNYDLIYTILVNPSSVAAISPLPIGTINAIENKFKDACHIAHSLDNRRGQIMGEAEQQIEALTNLESMKIVECAFDELREHATKHSLIVASDLTQGITAATNNLARCQPEEVDHTQSDVNCTVINLNSAGFPEVVSRVSSDDKVVNKYIQPSDASDTTPSEVSKGGLAASNNGSATPPDTEVDGEAVSERYHLNDEERAVFAEAAYRSYNRRLFNDVLPSNMQIQFADIDDLSVLEDSAHRIDAPTIKLNKMLDDARLIFLQLITQMVNIGFTSSTHNIEMDCLRYFGASYRSAFKQLHVNQQQLIRSRLLPISREARLKAKEKSKDGVNQKYVKSLKEAALLDSDGKKTNSLLDMEIDEFVDEVLDGREKVQRSNHDASLCNPFEEYQALKSFARHFINWKQTKTSFEEAAALDVSASKAVMEGGDNLLPIVNNHVIRNVWARFKFEHLEKVLKKSGIEMPLSAPLDLNWQQLLNEEQQFKMMKYLSLSAEDGDSIFTMLVRSGACTPTEAYAFLIKLADPYLKLEPYPTTDSNDSGEYARTPGARAGVAENTANGNHEGSDEESQEVDPFGNERFSGELQALMRNMDLPTAETINLLVDKLVHRNYADAMGILSTHPKRSYLKEMAIKFLDVIRNNGVLDERHHIEILEFLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7U7</accession>
    <name>A0A061D7U7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767170.1">
        <property type="nucleotide sequence ID" value="XM_012911716.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D7U7"/>
    <dbReference type="GeneID" id="24563525"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201410"/>
    <dbReference type="OMA" id="MQQWLYR"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1541"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1424"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1680" mass="190819" checksum="48F5930C7161DA5B" modified="2014-09-03" version="1">MEDDKAARQDPLPSQCSFTMQQWLYRRTPHTKRYKRCYIMLHHNRLYTFRKPPPFRECEPPNVPGVFRHATASWMIAGAELKAESHSTSGLYKWRITVKPIKQYAGEINPALQTVRTNTALVDAEEAQEGLINDIFKDINAGNNAARTARKPYADDSTVWLATSNHKVASDWLLAILWTTRYGSLQNFVEQNQLRSKYVAYGLPTYLLPIEFFPKSENVETMPRRKAAFTFMKLSVVELLQVYSPAYSPICCVVEHNSSFYVLNLPRQSPATHIEVPRVMSYLSTIDEESHADEVRVQHPGDRPLRVVDMNSGLETIAGKDFARASTLDIYKPESTEAHEDERVKTRAASSLATTPQQQGYNMLSKLWHLNKTSDKKKVVMAKQSYFYGDEACLYIPMYQHTCQDYVWMHFIAANDVYLGSAALSNCHFSINEPATLKTCVLKQIEAVNPLNQKRIDISDHPNPESVVNTSAANAKVPEAGYVVLSVVTPKHFGNFLDPVALSHNSPQEYIANATKASTAGGLQMLTSNIKRVVAAYRNARSVLGYMKRVIHFTDASLSFAWLIYFIAVLGVYSDKLLLFIIVPLAYCSLRSHPDSARWVRDLLLRYPLLIALLPQRLTEKFLLLPKSVCMVCTKRKAFLQTNSHTVSDVVTRSIAAEKVQMLDLRIKGFISSYGKGSPKQQTQIARIEHREPPMLTEKQAMNAYVSYTAHAGTRHETCSHRGVLHTYLAGLFLSQMDTGSLSNLLQTDGKTMLRAIHTIFYQPPPYPWEVVPWVQNVVLTVKYFAMAALLTFAGGINNIQTLHLLHRNRVATKLNVEAVAQQGGVAHPAQREQQEQELKTNHVPPVAEITEWYENERKSVFGTYSKHNLRFYDRPHVSAEDGGHVVIPDFLLYHSDVVVNKDTDENGWVYAKNWNSAWSKETHAFAFVRRRKWVVTGRSAGNVNRGAQGSMARVLTLSPMKRYAVAPEMSRGSSTKADERDIQPHDLIHIKDRAHSKPRVLVYKKGTKALEIDQYHVKNPSESGATSVDHSPTNRGYTSTATGTNRCGGAESTAPPQNEHDASRNKRHSSGSRGGRFRALVALKRGIYHFKRSPQNISDASPSHGSRSKPQQYGESKCRFNFLKLKKRTKRDNNVEDTADLDSDREIIPFAEHTVSPREAAAISFAEPLPVAFDRPEVNVQAESVEEWLTDCEEEETEPTPPRRSWLQNIFTFALTLLPCVVLDMFKVFFTVAWIFISCSFSRQHRITWQDDDTVLEGKIRPAAHAAPGGGMPFGCVLTTHAGKYAFHIRRPRKGCFMGNTKLRIYNAAKGHQCRLQPFSKYRQIARSNVIFLHTRQCQLVQAEHDPEDDDFEIFSMLSEDEVQAPDDTPTRMISAAVQESEESDAEETSSESNTSEGMVYQFSLETDGGEIDLSAIRVESKDSQDFDSARAEPATTPQEQHNRRGRLYSYFKSIYVNKIRKRQPEFSCDPELEADEPKELSDYDELESDEEMETEHKITMLGMLRKARDQIVLGNYYLNLFAMRYEKFLNMFSWRHPRVTQLIILMCASLAIGNYFVGVSTMLLVYVLCYFKSGFVAGTWERNIRLAVERHIDSCLDDLDIHRPLWDLNSRQVAALTQAIHGFSQVEVPSTLIRESATRRDIAQAVTAKIIEQKLCMNWERRGWFRNLFRHSPTHLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Z4</accession>
    <name>A0A061D7Z4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768854.1">
        <property type="nucleotide sequence ID" value="XM_012913400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Z4"/>
    <dbReference type="STRING" id="5866.A0A061D7Z4"/>
    <dbReference type="GeneID" id="24565209"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305720"/>
    <dbReference type="OMA" id="SVIWHGS"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="152"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="229" mass="25759" checksum="2D44844576E264BD" modified="2014-09-03" version="1">MAALLRYGGHMRFPGAAVAEHVGSPGTTWFALAQRMGKKKRRKVEKVTKSKEQIECATSDVIRLHDRVGVPETAHSMAQTIRKNVRGVQQGVVTRKHIARMLQYRMAQATGLTHDAPPRNAPDAFVTPLTRLQHEAQLPTMLDQPRHQFPHVLRYTVDWLAEASPGEHEKLTEVTLSFNMHDLGLSEMQLRKMKEILGADNYDEASGVAILQGDIFETLNHNAHYLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D806</accession>
    <name>A0A061D806_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767245.1">
        <property type="nucleotide sequence ID" value="XM_012911791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D806"/>
    <dbReference type="GeneID" id="24563600"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202160"/>
    <dbReference type="OMA" id="IKFCVEY"/>
    <dbReference type="OrthoDB" id="361835at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33828:SF2">
        <property type="entry name" value="NUCLEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33828">
        <property type="entry name" value="OS05G0596200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="188" mass="20218" checksum="5EAE9D0B8C1BD667" modified="2014-09-03" version="1">MAKEEGEKVAKTASAVKTKPAAKPAKEKAAKNKEAAAKPDKKAVKKTVEKKPAKGGKADAKKAPKAKETKKAKPAPRASRAVKVEEAPTIFRKAGQKHITPPKGDGTRGFYESLYEANPRSIIAIVYCVEYGLFGGLKHQELLEQYQELRKEGLLKGGNGGVRPLAVKFLDKFNAKSKAKAAKAPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D860</accession>
    <name>A0A061D860_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoporin NUP116/NSP116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769047.1">
        <property type="nucleotide sequence ID" value="XM_012913593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D860"/>
    <dbReference type="STRING" id="5866.A0A061D860"/>
    <dbReference type="GeneID" id="24565402"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307650"/>
    <dbReference type="OMA" id="YIQNEVQ"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="792" mass="80930" checksum="92188214DD3D32F3" modified="2014-09-03" version="1">MAAPFSFAPASGANTVPIFGSSGTTSLNTASTPAFGTSTGTTVSSGIGQFGASSTPGAAVTFGAANKVGGGGFGQPAPAVSAIPQKVNSRCSVRLLTQLIPQWRGHFDVADLLLTAHEKNIAKVRPMVDRLVELDAQCWQSHDEIKNSLNGISLLQTKLQHEVNDRCKRQDAQNLLSIKARRLSESLRPNETPRGSKISAMFRVPNHLHVQLTKELLDNIRSWRNEIHVLNMEVLSLKDIDLSQYVTTVNRVLSSHEKRISTIGDRLTKALRGMDDKSRNREELWSGVADEPSELKKAFLTAVGLPIRPPASEGEPIATSSSDTGNEIKKQIAYLRKFNTAFRETGSYNLDQSGYNIREILQQPTQPPTNSQLFGATQPSTGLFGAGTAGSTTTPLFGGSTANSGGLFGNTGGSNLFGAASKPAGTTNVFGSTAGTTGSTLFGGSTTAATGTNVFAPGGTGTNVFAPAGTGTNVFAPGSTGTNVFAPGGTGTNVFAPAGTGTNVFAPGGAGTNVFAPAGTGTNAFAPGATGAPNVFGGAATGTSGTPNVFGAGATGTSTTTGIFGAGSTPTFGQQQQPNTTGNVFGQQPASSGGLFGQQQPSTSGGLFGQQTNTTGGLFGQQQPAASGGLFRPQQQQQGATGGLFGQQPTTGTGLFGQQQPATTTNVFAQQPGTTTGGLFGNTTTTQPSTTFTFGQQQQTPATGNVFGQQQQPNTTGTVFGQQQQTPATGNVFGQQPGTTGGGLFGGAGNSTSLFGQQNTGGLFGQSTSTATPTQPSKSTAIVPYNPNPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D889</accession>
    <name>A0A061D889_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767320.1">
        <property type="nucleotide sequence ID" value="XM_012911866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D889"/>
    <dbReference type="GeneID" id="24563675"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202910"/>
    <dbReference type="OMA" id="FIRICTD"/>
    <dbReference type="OrthoDB" id="366232at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="332" mass="37066" checksum="AE0637B1222D409C" modified="2014-09-03" version="1">MAPYGASSTDASRQNLSYKRYRSRSRSRTRDSPDAAPSRPRREDSAKAPLATRTGGKHPGSSQSPVATKPDGASNAECNPNAGDDGSRGNRSTLPYIYQQREFIRICTDLIRKCECESELKSFLSSLDNGASVDLGRYGDAHVRKKFRHLARALYLHRSESTVRKPPECNISLLEALTEKLPYIRQKAQAQGPYVRHSRPAESSEPSENNASDMSQSNTTDPSDRELLSLREMHEQGFFVEYEALQKEFADRHASHDVWGKTPQEQLAIMREKESASKSSDAENSQPWKVFDREKEIVSGSKIDDKGYAHLLQSGKNLGEIFGPGQTHSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8B7</accession>
    <name>A0A061D8B7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768408.1">
        <property type="nucleotide sequence ID" value="XM_012912954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8B7"/>
    <dbReference type="STRING" id="5866.A0A061D8B7"/>
    <dbReference type="GeneID" id="24564763"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301270"/>
    <dbReference type="OMA" id="CERIGFI"/>
    <dbReference type="OrthoDB" id="361933at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595550" evidence="2">
        <location>
            <begin position="23"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="501" mass="56640" checksum="64020F169454EA35" modified="2014-09-03" version="1">MESLLFLRVVLLLGCLTKTCSALNVLGIGKTTYSGLLFHNAYTNNLSSERVTAHRIRCRTSISKPNYRCERIGFIYDTATPAWRCRNVRHYRLSVSDRAKNVDEIFDTLCESLKSKSTSFVDLKNRLNTAGVSLEGCNTPEDVVRRVAQLEVYGKEYVDDEMLKSSPTFQALLNEILTETMATYKSKRGREKTQFIQQLKGLLTSKNVCIANNITDEDIIRLASEQESRERMSAQLPHTKPCNEMSQRIDSYRDEADSIFAVYRNIKDDKLRKSFLSQVKDELNALSVDHKDCETPEEMINRLAYGRVFPQEKDYEAESHKRTAEHALLPWPNATVDDIYQFSAILGDGHGIFGVNGGIIDNFAGMSDMLEEDGLFAGSFSLLKDLAKMFGVNIGSSEKKRIVFENQDTAPNSPLAESSDDPSLDESEFNADELQPVFAKVKQTTDKNLLEMFKKSVKEATLRKALQLAHSSGYDTAREAYATNKMALYILDKFKERGIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8C8</accession>
    <name>A0A061D8C8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766176.1">
        <property type="nucleotide sequence ID" value="XM_012910722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8C8"/>
    <dbReference type="GeneID" id="24562531"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103120"/>
    <dbReference type="OMA" id="QNDINGY"/>
    <dbReference type="OrthoDB" id="385798at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="753" mass="82325" checksum="DE7594A0E60D3823" modified="2014-09-03" version="1">MEDLHVESARDISKPLDDTLLAAPGMHCGVIGEESTLHLSDIKGAECIGGNPAPIKATEAELMSLASIETQPPPIYNQFGSVYANADFSYDPDKQYSGIGAYYNGCYGMEGPWPCNVNQSLDGIESLQSQLSLDSQSSVYSAPGKGATKLEPEAQPIGTTLMDMQNQESYLQQQQPCLTHGLPNKVVAMNPVILVDKVERSLIVQWYENGVKREQRISYKKYGNAKAQQRAESLITKLMSGSTFDQLYPEKGPPILTIFENVGRYNVTLTRDRILREWRVEWTNNTGGNMRARWSCKKVGNEEAKRRAETFANSLIQGTFNPRLLHKATGTRLSRNDMKYSAVVNDPGYDPNNLPYGLNVGQRRHRKETAPRRKRNMANAEPGRKKGTRTVTRKRQMQGDLNAPPNGLPLDVANTRLDVSYPGFYPVVADPNEQDCALNHSFDGMGSQGEALAAQNWLNWSAAGQKPPYAGGSEWDFGELQNDINGYGKLYDIPQTNSMPYGEWMNTNGMAKFGSPTLDAPMTMCELAEDAPADSQNANAPFFACYPYFPTNQSICYSDPMSSQDQLGGSGTFFDTDFLSESQNTNPAMNYASMQWIDPDMPNADPGSAHLMMSTNSNSDGGMPLLSAQMKGKKSRKGKKSSDESAVSSYDCGADVTGVGMATAWQAYNGFPMTAINMNGSGSPSDFKPMDMYNGEGGCIRIGMGDASKKDKDMSKEAAGAPEMPGFYAVPNMVANGGMQSTHAMGNMGNLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8G8</accession>
    <name>A0A061D8G8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768453.1">
        <property type="nucleotide sequence ID" value="XM_012912999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8G8"/>
    <dbReference type="STRING" id="5866.A0A061D8G8"/>
    <dbReference type="GeneID" id="24564808"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301710"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301710"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="337" mass="37300" checksum="B55EDCD34F38AC70" modified="2014-09-03" version="1">MVYTSLTEAPHNVKEGIDWLMALKGTSGESTLKAMVGAIHHIFSEHSDGNNPLPSLDKIKSISKEFLENPELRDNILVKTLLRRFYTPTSAANTGFRRYWHRQFDEYGRVVGVKGAKPEYIEECLSNVMDGFAKLLDDIKNPDEYKSAYSSKATWEASCAKDPEACAVVLVGIAPMLYAGLRSLWGTAEFKVGPFHKHTARQNLGDVLRALGYVEPECRSGMDGSYIYETFRGLDKDLIHNTYDLAGFDVFYGSKTPVPEKAEPSAESTLRAKVRKFYMGSREVYGIPGVDIDMGLVNAWNSKNAKKPAKTLTGLGSDNIYYPGAPTVANLNAASFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L1</accession>
    <name>A0A061D8L1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain, G-beta repeat containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0204070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767435.1">
        <property type="nucleotide sequence ID" value="XM_012911981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L1"/>
    <dbReference type="STRING" id="5866.A0A061D8L1"/>
    <dbReference type="GeneID" id="24563790"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0204070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0204070"/>
    <dbReference type="OMA" id="MCWDIRT"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR95249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="317" mass="34729" checksum="F03E5C6FE1634566" modified="2014-09-03" version="1">MIDMLPCVALPLRCINAIEFDSTGIYCLTAGNDRSVRLWNPARQLHIKRFFGPHNYHVNDVCLSADSAHFVSAGAEHSGFYWDTAEGKVIRKFNHGGSVACCNYVASGSLICTGSDDRNVRFWDHRSRGAVSTFNDAKDGISSVCERDCVVVASSVDGAVRSYDLRKGLLKTDYFQKPVVNVCVSTAVEDCYIASVLDDTVALVEHGDVLARYRGHTCDNYRIHCALDPCEEFVLCGSSSGTIFCWSLSNNRSSSTVPGAHSGPLTALAFSNPSLLKDGRLVRDLEKNVIDSLREKGSLLVTGGKDGYMRVWRFYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8L5</accession>
    <name>A0A061D8L5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769049.1">
        <property type="nucleotide sequence ID" value="XM_012913595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8L5"/>
    <dbReference type="GeneID" id="24565404"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307670"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="68" mass="7428" checksum="22C43777B3516EE1" modified="2014-09-03" version="1">MACFCGSACKDNTGCAFKYLGVAFAGFIGFSALLVLVLYIMGQIYNMSLGETFGRLRDAFRDSKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8T5</accession>
    <name>A0A061D8T5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BIR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768558.1">
        <property type="nucleotide sequence ID" value="XM_012913104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8T5"/>
    <dbReference type="GeneID" id="24564913"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302760"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302760"/>
    <dbReference type="OMA" id="WPSRNWD"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="27645" checksum="E482172392311BF9" modified="2014-09-03" version="1">MGDKLCKTAAAAVVNRAVRELPWRSRFDILKERVKPRYMAECPGTPRREYQENVVNGIRIAPTFNPYVELNKEKRYRLDNWPSRNWDDWNPQSCYVRGGRRRHAVPKAFLPIKDELGEAHPPKISARYRADIEKQYYMNGLPWVWNTDYYLGKVHYHDRDVLHPKVWYRHAFKKQRMEMELKRLDKHMEEYREQNRLKKRHAYFDKAIAAIAGEELASKYIRQRKIAKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8T8</accession>
    <name>A0A061D8T8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0104690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766346.1">
        <property type="nucleotide sequence ID" value="XM_012910892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8T8"/>
    <dbReference type="STRING" id="5866.A0A061D8T8"/>
    <dbReference type="GeneID" id="24562701"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104690"/>
    <dbReference type="OMA" id="HPHYENK"/>
    <dbReference type="OrthoDB" id="366038at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF1">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR94160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="867" mass="99008" checksum="D970BABC260EBAF6" modified="2014-09-03" version="1">MKSHPYLSATLSVCSSATNRLRLLVSILLLRRYRGIFDLEPEDQKLMYYSEDIYNHEQSAFYLSFYYDVVDAPSWAAVWNALTHDDRTEYPEIVVAFKRLNIVQASCAEIILGSFYRLCNLRYIFSNPFNFYAFAVLVLNAGGVALLFLLACKIGKSRWAGVLFFGLYLSNFYEKLISRISALPLRENFALPALWASLLCIRHILAHRRRVSRHYTFLFVAYTWMILTWQLSLHILATQLGCLFLLNLFNAVTDAEMKRISVVALGSLTFSWLLMLCPSFLLTSVMFTGCLAVFISMHAIQPDGICSQRFRVYTAFQKVMLSLTIFVFANALIALTSRHDGHINEILLSKLGLSRPTFDSQIYLMGAEFRTISAGVLQRIASTRLFHYAAASLMILMLLSCKGDRSIRGFQGRFNYYLGIQLVVFASMATMVSRLRVLALPLMCVFSGYSMLLLRLPRVKTSNWITMLMISLALAPYFTTMPVQEMRTPPVGELYNRDDLKDLVQWVNHHLESGTPILSDMPTSSALRAASSARIVLNPQYEYTPLRRKTHFFYTLGDCNDARWFGETLRGRYKTDVVIVPMKFCTIPRDKGPYGVQKLLSLNPLGTCPSGAPYYRRLCNRLWAGSSHFELLFSNSRYLAFRYKGPSEVAEERPWEVMHRLDHYKPWIEKHAVLDNVLGPRQIVSTARALSTHFNSPVVLPLLRYGLEMFPGNEDMLRMYAETADYDLAMFDEAKKYYEIVFESMGSRCHNPEDLTFYAMYLSHMVETGTGEDSEIMGVIEASKKCLGLTFPRLYAHQLCEHAVVVLKAFKNKLGAPQPSVQRAAVSFFNLSKDVNHQNECFLRNYSIFNAVDLTAVDLLIMFLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9C3</accession>
    <name>A0A061D9C3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0206820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767710.1">
        <property type="nucleotide sequence ID" value="XM_012912256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9C3"/>
    <dbReference type="STRING" id="5866.A0A061D9C3"/>
    <dbReference type="GeneID" id="24564065"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206820"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206820"/>
    <dbReference type="OMA" id="AMYKTYK"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="3">
        <location>
            <begin position="144"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR95524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="788" mass="88783" checksum="789FD3C66FE7CA8A" modified="2014-09-03" version="1">MEGLENLILRIKREPEAHREDFFRKWEEFVAALAVLKLTPHLYNATAMALLNFVAQVGRSGCQIIACQSVSFYCGPQQTNIDIRCVPSNAADSTGLSASGKGSQSVVENAQRVTGASSGVSLGVENGAANAADAPGPELGRDLCMMLIDFVKSHRKRINGKTLKQVISTTFLLRSKRLVDIFTIFPEWLALLDLDDRDVRRRLFVFIVRDLTIVSQQVKDARLTRAVQRLFFDFLKAKSIQVQLLTCCICVEMHKRRVWRDSQTVNNIAQCALASNLKLVLAGAHFLLGTKNHLDVAFSALEDIEEEIAALEDLNKQQQHPGFGAHSKKTEGRQNRLARTKKHVEKQLERRKRRLQLCAVREFAAIDDLHDPQKFTDRLFERCRNKDVTFGAKLILLQLVSILIARHRLMVPNFYGFMLKYINHKQKLVTKILAISAQAVHPDMPTDLLEPLIKQIMDQFVSEDRANEVITVGINTLREIAARAPCLFAKETIGQIVEFRHIKNKAVAMATKSFINLYREQAPEMLHPTLRGREAGTQLTQAKKEKTGTASQKFSSTYILSQEDFKRKKYMGPDEAEAGQSGSGSDHDDDDEEIGASEDEYDSNAEGSDEESEEMDSSEEDVGSESDAWVSDSEEESESEEGDSSEQRDKRGTASGSHPKRKPGRETDDDESEDSDEDEDSEAERIKINPNDLAYGSKRKRVAAESRKEAALARMERKKRRTAAESRAGNKQSTTNRVKARNKPVLMTMQSKRIVGKQTMNIAEKMANLKRHLKSLKKGNMKYKKRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9E4</accession>
    <name>A0A061D9E4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0207070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767735.1">
        <property type="nucleotide sequence ID" value="XM_012912281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9E4"/>
    <dbReference type="STRING" id="5866.A0A061D9E4"/>
    <dbReference type="GeneID" id="24564090"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207070"/>
    <dbReference type="OMA" id="VIWPCIL"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000002">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF2">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="9">
        <location>
            <begin position="283"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="9">
        <location>
            <begin position="426"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="10">
        <location>
            <begin position="692"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="788" mass="88517" checksum="B72C2611764A45C4" modified="2014-09-03" version="1">MQLLVLDSSIDSLVTWSAAECVCDSVPTVVLASISTESDLRSNKCRNEVHALKCLQELPLLCSKLESQDAHSVKLFTEHIGKHTSQPSEDVLKHLLKTLNEVPVRPLLFAVDSSVADVLPIFGCNAVLKYYVEGQGVCGKSSCDLYTPTYEQSAFDWFSWTSQLRLLCKKNASVDLRALLSQFDAYLHGQQECDIKVGIGSVVITLCLLWYETKLEFLGCNLDMFSHIRQYISAVLTATANVERYRCLHTFYRLHGTCAAPERSLASSRELESLCRDFIDRKFYVTTALAYTNGPPHIGHTYEIVTSDVLVRYFKAFGMSTTLLAGTDEHGLKVATTAERSGMHPIELADYYSAKFRENNAALLTDASLFVRTTERRHHHSAQKIWRILRDRGDIYLGEYSGWYNVREETFLTEVEAAATDYKDPLSGKPYTLMKESSYFFRMSKYQQQLIDKLSGDPLYLQPESARNEILSRLKKPLEDLSVSRCNFSWGIPVPDDPSHVMYVWSDALTGYLSGIGFGDFDDISQLKLWPPDVQVIGKDIIWFFAVIWTSILMSLDVPLPRTIFAHGFITAADGRKMSKSLGNVVHTKELLVKYGADSLRYYLIRDSVFGSDVKFDLSSMADLHNADLTDTIGNLVHRITTLCTKFCSGSIPPVAEKSSPRPFDMVDVAAKTLKHLQDFALQDALLSVIEAFRDTNKYLTDREPWAKGSALTRHDTIRNVLEAIYFLNHLMQPVIPQAASVVFKKLNTPPKIHIGLLSADYDNLREGTNVVVGDILFQKVVAADKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9E6</accession>
    <name>A0A061D9E6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0311940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769477.1">
        <property type="nucleotide sequence ID" value="XM_012914023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9E6"/>
    <dbReference type="GeneID" id="24565832"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311940"/>
    <dbReference type="OMA" id="CNDGIDH"/>
    <dbReference type="OrthoDB" id="364143at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="491" mass="55168" checksum="1E8D20B2DF32BF81" modified="2014-09-03" version="1">MVGPEGRGKTTLLKELMKQGQIPGPYDLRYAYYDFGANANHNFQVMVTQWSSSLISQNPLVGKIEHDECSKVFDAVNGEHDILQITGATWHDTCLLLLKHAPATLGIHNVSAVGSTEPFFYGLYAVGIIAEKAEIESRGEANPSSLLTGTWATKYLLKACSALSQLHRSRLVLCFDGVHHLTRSPFLNDRGGRFLHQLLSGMQANNLHSVLISDDCVSTMPLVDERLSAKLDDVSMQPNEPPSAEATVDRSSLVWLDVPELEPTVARAALKQGIWNCDRVVKALMKVSGGNMKLLSNLVRSYREMELSLDLPAVHQILAGSVSPVDDEYFPLKGTVEEQARYLQEERCKMFVRNVHNAALATEVGQFENLMNRFLSLPAMEAVRHRLNNNVHFWVTVSETVRYLLSKPMLQLRPGATIDNKVVLSLISTGILHLNVQHRTLEFKDSLTRFLIEAFIDNEYESLSWIEQIEYKANYLLNQRTIYGETDRFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9F5</accession>
    <name>A0A061D9F5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0106490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766526.1">
        <property type="nucleotide sequence ID" value="XM_012911072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9F5"/>
    <dbReference type="STRING" id="5866.A0A061D9F5"/>
    <dbReference type="GeneID" id="24562881"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106490"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="268" mass="29614" checksum="E9C54391984B8420" modified="2014-09-03" version="1">MIDVEGEMPGDEAMEASGNATEILQKSFQLYPLEKVNYIKAMSKASGNDLFNFKKGTTTLGFVFDKGVILAVDSRASMGSIIATQNISKVIEINSYLLGTMAGGAADCTYWERHVAKLCRLHELRNQERVTVSHAAQMLANVFFYFRGYGLSAGTMIAGWDKGKGPSLYYISDSGERVSGKLFSVGSGSLFAYGVIDQHYRSDLSLEEAVELGKRAIYQAAHRDAYSGGYVNLYHVHENGWTKIVDYQDVNELHYKYCNEKGVPGDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9G5</accession>
    <name>A0A061D9G5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0310910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769374.1">
        <property type="nucleotide sequence ID" value="XM_012913920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9G5"/>
    <dbReference type="GeneID" id="24565729"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310910"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310910"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="260" mass="28693" checksum="761BF5C301039571" modified="2014-09-03" version="1">MAEGKGTNKCGCDSKLENGHKEGPCDERNCVDCYVCCMADCPGCKALQCEEQNGCKCNLCDCGCQKDPEVKKGTKACHEINTDKCKNCLTKCKNVKKGGRCKCYLCNCGCNGVNCQCCKTCNPNSKCSGTCDRDDQHSEKCAHQERGACGGTVNMGKYHCAEHRDRSQCDFSRCNPIYFGIGKCRFKCTNCGKLCSQDQCRIRMRIIIVVAIILAFLLILWALFPKKVRGMMIRIRAALSSSPRHTGRSLSNLVGDRIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9M5</accession>
    <name>A0A061D9M5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0207790</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767810.1">
        <property type="nucleotide sequence ID" value="XM_012912356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9M5"/>
    <dbReference type="STRING" id="5866.A0A061D9M5"/>
    <dbReference type="GeneID" id="24564165"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207790"/>
    <dbReference type="OMA" id="GQVMRNN"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="13">
        <location>
            <begin position="537"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="988" mass="110170" checksum="9419FC5DF6280F2C" modified="2014-09-03" version="1">MEAVEEYEVLQPSLKRTLRTFWRASGHRHVKRFTREVYHRADIGCGVDSCTSCVRSQIQGELDGSRPLLVLTVDVVMKQITFCERCLDNCVIPATVLNEVRRRSLSMYARMKKLLLPGNPAAAAANGGGVADVELTDDAGADVRRFYLFSNENFEPTYVEEDDEETAAERDQRLIEKCATWYQSHLPGCRVILLGNHDDPASPTESQDAVSLEPTLSAPSNTSDGTGMDISPRGPSAVDIGQAAFERLTVEQWARELQAEIADALEYVAAARPDCASGGATADDDGCYPAHLSEAEMQAGIETGRYYSGILNMFTGSFQNGYVKCGKDEFKVSGTANLNRAIHGDNVCVEVIVGEHANASASSSTAAAAAAEADAPEELVGEESEGATLLDATKDEKPAECIKQECRVVGILRRNWREYCGTLLPVDEAAEVTGTHHAVQRVFVPVDARIPFIFIDTRKSGELDGKRIVVAIDSWDRFSRKPCGHWVEVLGDVEDMEVESAVILREHDVITRDFPSPAYKELPPANWTASADEIARRMDFRNQLVFSVDPPQCKDIDDALGYRVLANGHVEVSVHIADVTHFVRPDSWLDREAAQRCTTVYLVDRRTDMLPSLLTTNLCSLVEDQDRLCFSVVWEFDQRNEICATRFGKGIIRSRRAFSYKDAQALIDAGGSDEITQALQGLNRLAKLLRSKRFERGAVELESPDVKFEYELTDIRKMEKYILYDTNRMVEEFMLLANVSVATKIFERFPTCALLRRHPPPMEVRLKALQRSLSQHRLEFEFGNSRDLNASLKRIVEKSDSRLGSALRIMTTRCMSQAVYCSSGDSGADDLRHYGLCTDLYTHFTSPIRRYADVVVHRMLAAALDLEAMDTSFFQELPAQCEALNRRHRNANWCGRESTKLFAYLFLKKQGSVATVATVVGATEKRLSLLAHEFGIEATASVDVSAFDPETQRVTLTSGRHVNLFDHVKITLNSSNKHFRYNITAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9V6</accession>
    <name>A0A061D9V6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDK5 regulatory subunit-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0108230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766711.1">
        <property type="nucleotide sequence ID" value="XM_012911257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9V6"/>
    <dbReference type="STRING" id="5866.A0A061D9V6"/>
    <dbReference type="GeneID" id="24563066"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108230"/>
    <dbReference type="OMA" id="HKYVTYY"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="415"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="471" mass="53941" checksum="58FA1847D51937D1" modified="2014-09-03" version="1">MSPVELPYTQVINWVMARRKTPDDCHKRLLALEDMCKEFFNKHSNLPENVKQLRKHVQSEYTEWYEVLTEITEKLKEVEDAEKVNFLGQYTFEPLYEADKILRNFQKHNLQIVSYCQLLQKHVTYNVPSIKKSIETVNRELLDYKNRKADSTRKLNSGTAELRNRLKAYGINIEEFPFNKDFKVHLKVKLVEAIVNKNADATIENYRRTVELTQHIVSEILPVFVSFIRLHGMDGLYAAGDTMANVRQAAESGMTVVTSDESKGDAVEKPEQSEDASSDCVIQLVKDNDQIPLDEGKRRQIFETNLGNPAFRQLAMGEVLELRTFVKVRIDEMQNRSDSANYLFSQAGEKINACVQTPVSKYETYVKTLDEAVELLSGTEAMKALSLLKNRNELEKLAQVELDIFNRCCNEIEQQVSLEKRIETTSDALQKLAAELEAARETVRSTKAKLEKTAGDVMGEPLRIFGEVDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9V7</accession>
    <name>A0A061D9V7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767885.1">
        <property type="nucleotide sequence ID" value="XM_012912431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9V7"/>
    <dbReference type="GeneID" id="24564240"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208530"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208530"/>
    <dbReference type="OMA" id="KNWRIQY"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="109" mass="12703" checksum="2A136152BC04773D" modified="2014-09-03" version="1">MGVLSSISYVFVAPFRALRYRSASPEMRARMIKLGVICRKSWILFPPLMMYQYIREKDKEMYTAELFYKNSHSEDPACFYDPSKPSGTRPWKIQHDMALLSAAANDRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Z9</accession>
    <name>A0A061D9Z9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trm112p-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769519.1">
        <property type="nucleotide sequence ID" value="XM_012914065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Z9"/>
    <dbReference type="STRING" id="5866.A0A061D9Z9"/>
    <dbReference type="GeneID" id="24565874"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312360"/>
    <dbReference type="OMA" id="NMLTSKC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="161" mass="17759" checksum="422DDB61A35461AF" modified="2014-09-03" version="1">MRLITHNLLMCNRPRCSGGYPLRVCASMEDGSTKVEPQELNPEFIRKMLQRMDYGVLVEAARSLGTNLPESYSDADLESEEFIALVHRCILETHVLKGTLTCPKCERVYDINNGKRAAKLVDRVQGSQICSTARVASRHGPSLGCGSDLPVAHSRLVSDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DA30</accession>
    <name>A0A061DA30_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0209180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767950.1">
        <property type="nucleotide sequence ID" value="XM_012912496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DA30"/>
    <dbReference type="GeneID" id="24564305"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209180"/>
    <dbReference type="OMA" id="RFAFLRM"/>
    <dbReference type="OrthoDB" id="443345at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="442"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="544" mass="61563" checksum="CEFA1C06494F1EE0" modified="2014-09-03" version="1">MWLLRRFGRCFSLAVAQNGGAHALARRSAARLPAPPGASRGLVTSTQYHRDIVERAGACSKHVSHDNAARLLSQFVDGGFDASRLRGFFASEGGREGGKGQGLSIEDYLVILQLCKQLEFQDLDLLSSLSEDVRLAFVKTYAKPVKKRRGRVPVSKDADTSTAADDRPRSVPTREFQVDTSRVPALKDAVKATSVIFNELRILHDPLFATIGDLLLERSEEISTEEAELLLRTYATQNYRDHAVVNLLVRKVETDVESMGRGTVLSVYRSLSHLELISPPLCSALENRLCRRSDDGNEIRFTFHDEIDVNQLVKLGYSKLIQGSADPDAFCVAEKLPTSAASLTASSKRKLTTLMAYLKCLSEPCYSTLGDKPIDSLNEAICADGGYKKFRTTKFVEKVVATSHYLSHQQVSEHLTKLRIRHETGIYANGVLLDIMEKDRNVVWLCNSYHRFYAASFDPTAESKAMERLIRAFGFKTCPINYYQWGRLKAKRTRFAYLRMARYYALHDQREYDHRYAGWSLPYVWWNASRQDQMHVSNYIKYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAM8</accession>
    <name>A0A061DAM8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0402300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769927.1">
        <property type="nucleotide sequence ID" value="XM_012914473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAM8"/>
    <dbReference type="GeneID" id="24566282"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402300"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="256" mass="29108" checksum="6C2B511EDF0BEB09" modified="2014-09-03" version="1">MVYKSLTDIPRNVKEGIDWLIALRGTDAETNFNAMGVALHKLLADKPVGTMKVPALENVKQISKQFMEQTQLSSYGFVREMISRYNKRMSKRKPCFLYKSFIRGDQDECHYMNVVKAHNVTAELMSAQMTGITSSCERFLGHIRNPGKYKSAYSPEATWQASCAQDPEGCAVIFVGIAPMLYAGIICLWLASAPPLLRWSETTDNTHLRIVMKELGYVVPECLDGLTRLHVREALRDMHHRLLDVVYDMAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAS7</accession>
    <name>A0A061DAS7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEAD/DEAH box helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0402740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769972.1">
        <property type="nucleotide sequence ID" value="XM_012914518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAS7"/>
    <dbReference type="STRING" id="5866.A0A061DAS7"/>
    <dbReference type="GeneID" id="24566327"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402740"/>
    <dbReference type="OMA" id="VNTITYV"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="136"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="372"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="670" mass="75552" checksum="01D8C673406393C3" modified="2014-09-03" version="1">MEHPDSDAQEKPTEPEENHDESGRFEWAPLEYDAALQAEGLFGLEVLQDESGLPPIKKAKTVKEKAKKKKTPVKKQAKEEEEADTSEELPDGEIEKATRAWNSLLFDDWEIPIQVRRNLHAAGMLLPTTIQKLVFKPSLTGSANIVASAKTGSGKTLAFSLPIILALLKHERAGEERPILCLAVLPTRELALQVKDTIAMLLKGTSMSVFALIGGIAIQKQERVLKYKPEVIVATPGRLWDAMQELDMKFDLKYLVLDEADRLVSDKAFKELGSIVAKVRTSRTQNFICSATMLNKKKDLKVIFKMLQIKNPTVCVASHKGDVVMPYDQFAQQKFFKIKEDEETCNTTLPENLKFQVVKCLDNEKELKLVAYLMEHYSNVDHGRTIIFVNSISYAYRLEPLLSLILWRDKHELRIAKSHCMTLDKESKVNYITSLHSRLRQKQRLKRLEQFNKHDKAIMVCTDVAARGIDLPKVDGVVHFQPPRNASLFIHRSGRTARLSAQGTRSSSALMSVPGAAICICESSEAETWEKLFKAVNRRMDDEEEILGCIPQKQYQRWSPAEVPSNVAGYKKLLMLASSIEAQEHQVGGGNGIRNNVLQLTKKAKTESWLHTFAKQADIVLSDEESDEEARHSRSTTYKLLKAGKRKLLSVSPKRIESPKETQLRSNNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAV0</accession>
    <name>A0A061DAV0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein Rab-5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0111280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767016.1">
        <property type="nucleotide sequence ID" value="XM_012911562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAV0"/>
    <dbReference type="STRING" id="5866.A0A061DAV0"/>
    <dbReference type="GeneID" id="24563371"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0111280"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0111280"/>
    <dbReference type="OMA" id="DEEGLMW"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="223" mass="24718" checksum="2E67F69824E8B014" modified="2014-09-03" version="1">MRNFLGSLLPGSGNSAPKSDPPKAEGGHHPVYQFKLVVLGDTSVGKSCLVGRFVKNTFLEFQESTIGAAFMTQSVKFDDYTVKFEIWDTAGQERYRTLAPMYYRGSAAAVIVYDITLKESFHQAKGWIQELQSYVDPNIVLALAGNKLDLEASREVPREVAEEFANANNCLFMETSAKSGHLVLELFTEIARIIPKGKRIHDFHEGFKIDTGSSLSKINCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBJ6</accession>
    <name>A0A061DBJ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0301780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768460.1">
        <property type="nucleotide sequence ID" value="XM_012913006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBJ6"/>
    <dbReference type="GeneID" id="24564815"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301780"/>
    <dbReference type="OMA" id="EYKHNDL"/>
    <dbReference type="OrthoDB" id="361153at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595982" evidence="2">
        <location>
            <begin position="27"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="831" mass="93057" checksum="7604C4BA1B10BDDA" modified="2014-09-03" version="1">MYTCGAFALLPICAVLLERHAAECFAYRVPIEYATSARLAASRCSEALYTYRVKNSRSCVLFSGLHANAAGTEGGNNADDIEQPLAENPPRTQGDESTGTSGEGRTREEMLKEYRDAILNDGFDKQLTDLLLAQPDVPKDPKDHFPLSKCDWFHTDGPLDSDDEMFLRDYCAEKVPDIDDIYKRVDPHGIRKYAPRNITTMEKTLGRVYDVNQPLLDEDAINESRNTHTIPTARAAAAAQTGDTPAPAGSAEPSSDAPNECELDEYGRRIPSIGEIALTDNDYVVSTAADDDAKDEADEFRECDPDNSYDDALKDSVIEDDAYRYFVTLPMLSWTTFDKDALNTALARLTNYKEHYKESERQLGTSSPYAVFTSEPSSGVGVSDGTCEMSLSEELAAMETVEMNPVEMYMEEYKHSDLLNDIDAYEAAEYPRVVQRICASDANSPVFTMDDFTPKYAEVETVDPRVYVSVPKSSIKQDATGTLVLREQFLVKRARDVRLSSQVTDIPISSEPQIGTILIPNEFGYTDQNIRYLADEIGVISRSIVFVPDISDNDLVFSLTLNRLIKLMQTAFNVNRISLVALGSQGRRVIHYAYTAMRDTVERTLHDFKPVDPKFDPDKYSSMTNLGRLENILRRQKTLMVDDIISGIQRIEHNESVKAAESLRDYNVIKPLSNLLQSIVLWDSVGVNFKEVAQLGVPVQFNMSNRTNLFEALLRLDNPKFLSRKKKLTGFDHNEFIEVFDYAEAPLPPALQETLGEHVHLRYVGRSGSSDDKPDTYHMTTNHTGIDICLNFFPLASGHFYMKKPGAPRGELNSLGNAILSCADWINSWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBK1</accession>
    <name>A0A061DBK1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0312100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769493.1">
        <property type="nucleotide sequence ID" value="XM_012914039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBK1"/>
    <dbReference type="GeneID" id="24565848"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312100"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312100"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="301" mass="33183" checksum="95FAFC2A06C11E99" modified="2014-09-03" version="1">MVEGQGDNQCGCKPVSCQGNEELCSDDKCTKCEAPCPPGCKGCEVKCKEVKQPGTCKCCTPRCGCEEDCYASGKDGKCQEKNKIDCKRCIIRCEDGKPCLCHYCSCGTKCNGVICSCCSWCDPSNCSGGPCNGYVLGRCKDKYPETTECRGHVKYDNYDKNGTYGAVYKRDTENVIPCDGKPHKGKDCTDNNCNWICADEIKDGNCVLKCTYCGKLCGQDNFRRCCTIAIPLVIIVLVFLIFRFMLPEKFQAVMSTIRAAFPSSPRHPGKSPINLVGDKIFEEGKIDRYPAFRPRPYTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBX2</accession>
    <name>A0A061DBX2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770264.1">
        <property type="nucleotide sequence ID" value="XM_012914810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBX2"/>
    <dbReference type="GeneID" id="24566619"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405630"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405630"/>
    <dbReference type="OrthoDB" id="10303550at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="251" mass="28800" checksum="C47E6F6D7F59162D" modified="2014-09-03" version="1">MVYTSLTEAPHDLKECIDWLIALRGSDAERHLKAMGAALHKFLVDKPVGKMELPALEEVKLITKEFLERKPIQKQLFVKGLLRIFEEPMNRSGIVFRLFYGQESDCCNIVQQNHLEPYAMGLYLGRVVYGCDRFMKHMKIPDQYKSAYSSDATWEASCAEDPEACAVVLVGIAPMLYAGLRSLKYVTRLALQNEANEKARRRLKTVLRAVGYRRSKRRCNITVSFMSRALSEVDKDVLEIIYDIAGFWAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC47</accession>
    <name>A0A061DC47_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0400890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769783.1">
        <property type="nucleotide sequence ID" value="XM_012914329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC47"/>
    <dbReference type="STRING" id="5866.A0A061DC47"/>
    <dbReference type="GeneID" id="24566138"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400890"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400890"/>
    <dbReference type="OMA" id="QIHIMAH"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010297">
        <property type="entry name" value="DUF900_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36513">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36513:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05990">
        <property type="entry name" value="DUF900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1262" mass="140983" checksum="54B7A0D75DF840CB" modified="2014-09-03" version="1">MQYLQNTEKAINSMHNFEEDQNHMGDLPDQMHCNPDVDMLLKDCNDETKVQVLCELTDEGVLNDDMLPNLSPSRPADEHFSLGSPFESVSSMQPEMNVDAKQHHIIEIGGFGDVVTNREEQPSNIERNEIKDELGSGENTGNREEECSITELECIENTTHDVVPCTETGTMEPDVPTSSLGHLEIDVEESSEGECVYSKMATVYNGCAVLKCLPLLKDINGGDMAEQMQPNHNQNEQLATSLPALLTVKSVEDITPMSSADSHRQTVTNGPLELQVNSTQQSVRSAVNDETPSSEVRSTNVKVEVERHIEPSDLESLATCEGLKSECATMTSSEVGCNINLRKKDFAEDYKATIDTVSYLRETDEDQVTVDLSPKDEVKSAQQTAVTKAFMETIKYMRYREAFRKHKRENMQYSMYVCLLTVSSFACLLAMSNHLYGHIGDIFKPAVTYVGNARSYSFDDAPEAPAIYVSLLICMVTYINIFLFGTGTIYYGIITGTIVLLVCYVVTFFCNIITGVTIHSITNELVLYCLRFINLNNRILVNNVLFDNFLDLIYACFLLGANFWLLIQKFIMPLCIAKMYSRGVERLSVASMKPCVVVLPRDSTMAAACGKDAAGYIVEIECSAERCILWRILGYLTRNRVMAARTSTKVYQYVGQLNDRLKPHGYGAWQSSVSSGEVLIGYWENGLPLGAFNSRDMATDARFSNMLLGWAKCRVGGGLSMGIASVETCVNDPTYRSFCNIMKYRAEIFDCENIKKGLIKHTGTHKFKASDENLSNLQSDQIILRLIKATHNFIEYSFKQCDAYIHDIKRRDSAMGKVKDILGDILIQKPGTRHMNAVFKCIFKGMQYSIPYVAPYDELTVASDDNDANVCAGGCGLANATYKSNINGELDGMVSRESIGFENVNCISEQSSAIPRLLGSSMDLEAAVGGSKMGEYAHVPEVCIFVHGPKISTEEQLQSVANIFTPGSYPSYIKPIAFGWPSFAKIHETKAHNYSTIISSCRDVFETFLRSLLNNGVRHAHVVVDPTGAALFLETFALMTENTQSLSIFSDVTGKVEATPNQITLLSVTMMFPEYNLWRFVSALYKPLRAHCNIITIFGKQKNQGRLSFIFRKDGRKLSQSITELFLERSNVIESDQTNCSPAATFGQITLPSVGDDNGNGTRRKKSTMVWLDVDCINVTGLPALNDLISAKQWYHCREICADLRYVYNLYHSYDCRDLIVGCKRAKERITNLDRRWGNVWIYSASAWHPNFVHKANLIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCC9</accession>
    <name>A0A061DCC9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768825.1">
        <property type="nucleotide sequence ID" value="XM_012913371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCC9"/>
    <dbReference type="STRING" id="5866.A0A061DCC9"/>
    <dbReference type="GeneID" id="24565180"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305420"/>
    <dbReference type="OrthoDB" id="366065at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="317" mass="35571" checksum="4991D951D725E0D6" modified="2014-09-03" version="1">MIALIINHMSSEVINHLTKVTWDTIIHHPSVQPLDVISPPTSAIDLNIEPFDAAPHSITEDFDQKTIKQPDIELGLAPWATSKPAHDSTDIPETELFPAEAPRTVREMLQWIAGLKHEKHHETLKQCINKAFGGLHHEPSQLAIFINHTKIRPKDVFDILQLTAMFAGSVLSSIAPKWKANVSSRFVKPKSSDQSEEPDCCALLCQLRDYVYACHHQLEFLKSQCNRDKLSGGWKDYKYGSDLISPNSPLQAFLTDGWDSDFDTHLFDPCNLCHKSRVRMGFRDRDLPSSQQTGDTLSSILTPSCGGEQHDSLVDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCE3</accession>
    <name>A0A061DCE3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0402350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769933.1">
        <property type="nucleotide sequence ID" value="XM_012914479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCE3"/>
    <dbReference type="STRING" id="5866.A0A061DCE3"/>
    <dbReference type="GeneID" id="24566288"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402350"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402350"/>
    <dbReference type="OMA" id="KLGNPMY"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596017" evidence="1">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="249" mass="27219" checksum="1213958A9FD479E0" modified="2014-09-03" version="1">MRSTLLLPVDLLCFAARKVGGLSWGTKALLGAVGCATYYNKRRSAVTVHENSSLSEDAITDYVYFDLAADRRYLGRILIGLYGHHQPLTCENFVQMCKGYDVGGRRIGFLNSKVDQVFPRNGIIFGQLFHPGGPLSSCTIYGRTMPEESFELPFMQEGDVAMLSTSDQVGMTSRFLITLVGNPCLGRRPVVLGTVVKGMKLIRSLGNEQLDEGVPKRDLRIIGCGLYRGPEDGPKSFFVRGASALASPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCN2</accession>
    <name>A0A061DCN2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0403850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770083.1">
        <property type="nucleotide sequence ID" value="XM_012914629.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DCN2"/>
    <dbReference type="GeneID" id="24566438"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403850"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1536"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1608" mass="177435" checksum="CEEBAFB318CBE1E6" modified="2014-09-03" version="1">MTTFCNNLDTIKCVLALLAGLDRGAGNHIKKHLGRLLYQDHLTHLIRLGINAGNLQYSISRFISRANKLYVKLSKNARWHAVPFNLVNNANEPFEKLKQCLPKFLASLSYLWYHVDTAYGSGGGGGWADKRTRHNTHAICIYLTAKSSDADKYKGIFPGGFEFEELRSLMGRDLAAPLKELLTKDSHGYGMHNHFRNVLFFTLKERLEAVNTGNAVGVVYLFCQIVAKETKKSAFYSALIKSIGIRKRCFSWRKLKVVCAKLKLVYDDMLKNGFDIIGHLTNISHISTSSFVVKFVEWYRNHYDELLQNLKTMDSTVKKYDMFTWEPFVKNVLFPNGFIFKETKASDASNSLDLWHFIDVIEKLIDKDDGLIALKNVLEYGRCQPKTRRVPTGADLPTHQGPVTLNQHDSLLGQFFPIPQPVVSRNSVQHFDRDDLSQGSSYTTDLPSDSDTDQRDLSINPPSVDPVAAKGGKKNQVPSPPRQGSQSIGASGHSNGSVQTGEMGSSGSAPQGGPKSQVDQGPGLSPVSNVESPGSGSGTGKGVTASLPGPDESKTNDAQAGKAGSAGPPAQAPRIPNSGHDSGENKGNSGGDGTQFENAEGHISPVQRSDVSSDTTLTRTTSVSSIDSGSSGPSGKPHIPSTHSRDTVSSPRSPASPSLVNPLNQTDSSQGLDKDGGQHSGGNSNNPSTSVVNSSPQSSVTQGSVVLGPPRDSGASSQPPPTAPSVVEDGKDVHSPSVTTQQNGKGAQDSSRDDATASSTGGSSSDGVGSSGQSGPPGGKSKHTPFYSAFDYTSTHTWDIFRKQHYQPTLLHKDINPRGPFIRRNQDASNDHKDSQPSRDQAVTRQTPLGSDVRRPGQHERNIPYNGVFTAGPVDPFAIYGYGLSQAYTSVSGHSLVYKIPEKGKPWILPDKNYVAGEWTEIQDRVNSIFTGEPEADAKGLPQTVTRVFEVYGIPTGYPIKLQKPPMKPPTYSKKSMPFPPVPDLIGEAIPDPTLNTRLPPPPIEIKVRDPYSQYDTVNSDIARRPSLPIVESVKIPLPSIKYSRPPPSKPDKDGNYDDPDTWGNFKNYGLYMYPSPDICRNAWNYVYTFPIPPTQLSPPDSDLLPSPTTVREMLYWLVGLLEYGYIAKIAEYVEAILLDFKISYQFPEVLGITGFENLTISFVVATLTEACLYAANVIYEMKYYDDYETVKNLQFDAVYRKLHYSSETSCLLCQLRDYVYACQHQLAFLRSQCSRGKFQGGWMDHKYGSDITSTTSPLQAFLTDSRNSAFKTHPFNPCDICLKSRVNMGFGAEDLPKDIKTGIALYNILSPNCSIDDPLLILSPYLVCLTGRTPRTTGELVSFFQHFGNEMYVAFSGELSNVGAALTEPPALYPIWDHLEAHDLRTVRDIRGSYDSKADHPKTLSALIGCDIYNVNCVNHFTPITYQAYSLYSPIFAHTYLIWMIHFADILRDSLERLRAEFRCHDCSNFNSVYQCEKVMPLLYLHGFTPPDGTSKLSLTCADVVKTLDAVVYGRPVANLISLTDEFLYRVRKPFILFGLAIWSLTAVYFAHIAICRLDVLRLLSHRIRTKASHLINIAALLAHGIRMPSLYDIQYFDDDLHTYWFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCP6</accession>
    <name>A0A061DCP6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767886.1">
        <property type="nucleotide sequence ID" value="XM_012912432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCP6"/>
    <dbReference type="GeneID" id="24564241"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208540"/>
    <dbReference type="OMA" id="LFWGISE"/>
    <dbReference type="OrthoDB" id="337840at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="377" mass="42379" checksum="A2C2E3EE2502B07A" modified="2014-09-03" version="1">METYSGHLAAELLDVAGRYLHACNLKSFVLPLPFCDETILDRNSLMVKVLGNASCLSKEQLFDVVHALAGDERKPRYKFDEFSKAYDSVSATNQPVRIARKAQPPQSGIRSTLRPSTTALSEKLMLELSSMHEPAEIAQKIDGAFFRMSQSDTVGFILIIAAERITNNAADEDNFTKIIKGSSFQIKVLQRVFYEINRAYRQKVTSHADDGQFLPLAGALVELLDAEEHCIRSLWCNPKLSKKEEPEFEKILVIRLLGHLFDYGFPGAPVNNKLKHASVLNVHGILFPSAAYTFLINGLKFGKHFETQQNGGSHEDSNSNFCRCHRLAESSDAELFWGISESRLRTTFYNVKASIPVKPSEYTLSMLQKILKRSKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCV2</accession>
    <name>A0A061DCV2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">endopeptidase La</fullName>
            <ecNumber evidence="7">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0308080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="7"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769090.1">
        <property type="nucleotide sequence ID" value="XM_012913636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCV2"/>
    <dbReference type="STRING" id="5866.A0A061DCV2"/>
    <dbReference type="GeneID" id="24565445"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308080"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308080"/>
    <dbReference type="OMA" id="WLTNIPW"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="11">
        <location>
            <begin position="276"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="10">
        <location>
            <begin position="957"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1000"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="1080"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR96904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1175" mass="128590" checksum="A025625490459710" modified="2014-09-03" version="1">MWLMQRCQGAAVRHGVARCQQEVSALISGNARRGFTAESAAICWNCNVRGSLLHSGSSRREGALSSVFDARNARHFSSKKRGGGSGEKDSDPGSNGGEDGKPEDVDQPPRVVGTIFNGPPNIVFQVIRGQNAAKQRIGRNASGGKIRRLPIPIKTEEAASSGGEAAATEAHPADGTGHEEHPKAEGSHTSVPVEETTDGDAVDKQLITVVESVPGDHDGAAAVIDPQTAEEEVTVVANSGDKESEKIEAPEYDGNAPVQFRLPILHFHSTSRLHALPALAMFQKPAFPGFYQVLQIQDQAVLQCLSNIKQNTGNDYVGGFLTKTQHTRDFQNVAMPMLRDDAGAVQSYEEMHVHGTLLQVITITPHLSHQGGQVILMPHRRIKMTGIHAEPSESYPLFRVSIEYVEDDLKNFEDSRVTKALHLEIIATVKELIKTSNFYKEHFDHIIRIYNLDNPSRIADLIAGISMAKRDQLQAILAEVNIDKRLAMVLEVAKNDLEFAKVQAEVKTQIEEKMSREQRKYILTEQMKMIRKELGLESDDKNTLIEAFETEYAKVEKFMSKEASESYKSGISRLKQLETSSAEFGVCRSHLEWLLGMPWGKFTKDSRDIRNARQVLDKHHFGLKDVKTRLMEYMATSILKGTANGKIICLAGPPGVGKTSIATSVAELLGRKLYRFSLGGLFDVAELRGHRRTYVGALPGKFVQALKYTGSMNPLIVLDEIDKLGRDARGDPASALLEVLDPSQNENFRDYYLDIPVDLSHVLFICTANAVDTIPGPLIDRMEIINIPGYLPEEKLQIAKNYLIPQTLKSTGLQPDVIEMPDSTIQAVIQHYSREAGVRSLLRCIEKIYRKVALNIVMDNADKLEPAAVNSGEEPPIVLSDRDDAKDSGAIAVTNADEGASTAASSERGDQSAEAGAVDATMCSVLSGVDKLVIEEDKLQSYLGVPIYTRDALHPYPLPYGVVMGLAWTNAGGATMYVEARGQMVDKRGNIVEPNRKPASEIAAETATAEEPSEESSFGSFHGTLKVTGHLGNVMTESSQIALTFCKTFIRKHQPRNLFLDEAHIHIHVPEGATPKDGPSGGITMASALISAAAKKRIRPHLAMTGELTLSGKVLRVGGIKEKLIAAIREGVTTVVLPKTNEPDVLDLEESVTSKLEVIYVDCYDDVYAAVFEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCY5</accession>
    <name>A0A061DCY5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0405665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770268.1">
        <property type="nucleotide sequence ID" value="XM_012914814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCY5"/>
    <dbReference type="STRING" id="5866.A0A061DCY5"/>
    <dbReference type="GeneID" id="24566623"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405665"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405665"/>
    <dbReference type="OMA" id="WNREYAS"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023269">
        <property type="entry name" value="RCMT_subfamily_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF16">
        <property type="entry name" value="SAM-DEPENDENT MTASE RSMB_NOP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02010">
        <property type="entry name" value="RCMT9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="208"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="212"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR98082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="461" mass="51308" checksum="536AFC90A9836181" modified="2014-09-03" version="1">MCNRADDVQATELAAHRVEESAGKRRKRNDPAPQLEFNGDSVVLPTAVIAWLAHIGVNAEQYQRALYQVAKGLKKRYYRMLSDPEPSCEVSGVSKRTSRELSVPEDVDSAPSHTHKDTIVESSLASNSSEALANGSDSTLDGDSRCSNAHTKQHTPRHSHVRWLRDIELYECYSKIPEGSIGLDAASASIIDALRLSELRQENECKWILDICCAPGGKLLGTVSTVKRLWGDKINCKIIGLDIVKRRLDVCASLLKKENAPSNIDVHLLNCSGQSFTEFEGESMIERFDRVIVDAECTHEGSLRSVVRTLKYWGLHSLESRFTEEHAKTVISNQRELLRHAIRLVRPGGIVVYSTCSLHDEQNEILVASVIEEFDNVQLRQLPLLQCDCCSSVCDRPDAWPATSTEDKIRNHCSSRYLPNREVCSETSRCANHSSPVCVRFSPLSPDTDGIFVVSIVKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD20</accession>
    <name>A0A061DD20_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0309370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769220.1">
        <property type="nucleotide sequence ID" value="XM_012913766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD20"/>
    <dbReference type="STRING" id="5866.A0A061DD20"/>
    <dbReference type="GeneID" id="24565575"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309370"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309370"/>
    <dbReference type="OMA" id="IQFEDHM"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="132"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="372"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="711"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="776"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="839" mass="94520" checksum="1B806539960419FF" modified="2014-09-03" version="1">MKLSKKYKRLQRIAARYKAITEAVTRLEHVQDDDSTATIQDYANAGRRASDATTHPSKRTNNEKSQPLKDAATTSSARKGAKRQRKADIASNSTDGHQQDRFEALDIDRSIVEWLKTKNILVMTRVQKLAIPKFMKSGTDVLVQSHTGSGKTLCFVVPILDMFMKRARHFPDSGLIAVFAVIMLPTRELATQVHSVVSDAIAHMESGVEEGSEMCGVPLSCLVLIGGSPVEHDVKAITKLKTVRGARPLVIATPGRLHHLIDMLQQEMLWTFKDVTTLVLDEADRLLEMGYQADMTAIMGNMPKQRKTGFFSATLPKEVLEFAKMILNNYHFINADDGASHKGVASHGGEELQPESEMGHAEGAATYATPVTLKNYYLILDPREKLHFVVLLLEHLRMTGVRKCAIFFLTCDLVDYFSLMIAKCLADGNDQAKEGVRTILYKIHRKMPTARRQLNLDAFRKMPDAGVSKTKSDGGPKRLNAAADPASNTLQVLLCTDIFSRGIDIPQIEWVIQYDAPQDPNFYVHRIGRVSRAGASGNAILLLNNSEEAYVQFQINRKIPLMPLPSKVLEGATSYYDRISETESALPHHLHSECTTVANGTSYIDYLQETAPEQPVLPWIHTCKMLSYIRAQLTTDRALLLTATKAFVSYTRAYSEHRLKSIFEQKNVDYGALATSFGVLKVPRVKEILGKKLQNFANSDTDVNSVAFKNEGQERDRLKKLQQKNNETKPHVREKKPEPQPKVQRTRSEKRVVKRENALREWEELAREEALAKKLKKRKITREQYEKLLSKQEQSDSDESDTSDESDHDAQVSENDSDWETELDNFVKEWKDKPKTASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD37</accession>
    <name>A0A061DD37_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0210700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768106.1">
        <property type="nucleotide sequence ID" value="XM_012912652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD37"/>
    <dbReference type="STRING" id="5866.A0A061DD37"/>
    <dbReference type="GeneID" id="24564461"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210700"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="183"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR95920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="267" mass="30832" checksum="ABD2F632400DE96C" modified="2014-09-03" version="1">MMDDLMADTKWADIEADEDYDVDGIDAHRLMGFESAPDAQGIKTVTSYTKNRHGQTVKITKRVKEIRVPRRTNKAAKLREDMSCFKMDKNNDIGVTMVSQDEIIIEQPVSRRSRVNQEENLDLIYSPNDINMTRATRELKMKFKSLRDDSDTGEMMDDRDTSAKYIPPSRKEGGGDRRSFDENTVRVTNLSEDVREKDLVELFSRAGRIHRAYLAKHKETQFSKGFAFITYATRQDALNAINKLNRQGYDNLLLNVEWAKPPNKDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD79</accession>
    <name>A0A061DD79_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0211720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768216.1">
        <property type="nucleotide sequence ID" value="XM_012912762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD79"/>
    <dbReference type="STRING" id="5866.A0A061DD79"/>
    <dbReference type="GeneID" id="24564571"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211720"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211720"/>
    <dbReference type="OMA" id="LYAICRR"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR96030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="524" mass="57880" checksum="336B09DBD85FAC31" modified="2014-09-03" version="1">MQKLLDSCCKYCGSDQIESCKQQGELVCRNCGAVLQENNVLEAVQYAENPAGNSTLIGRFVPTGGGGMGSLKYSSSQTLDQLVRRGEQNIQRTACHLNISSELVTKATRIYSLAVQRNFTMGRNNKHVACCCLYTACRRFKAPYLLIDFADVLQVPVKIIGQVFMKLVRMLHLEVPNVDPSIFFERFANELQLKEKVDQIITTGVRLIQAMRRDWLCTGRRPTGLCGAALVVAARIHGIPLNAEAVASVVRISHPTIMKRLSEFRGTSTARLLTSEVDIVDLEKLPANPLPPCMMAKKLALEKKRRLESETGSTCSDNGRASITSGEDSPLLTSTQLQLPVQGKIDLHLSNDLLCLDAPTASDINHIADTIMGAAPQLGWALPKADGAGDGPNSSNSESIVPKAALTTIAIPQSRADGHLSSDDEDDEREFSFMILSPDEKAAKTLLWDEVTKDIMPEVWRRQAERKRKEALGKTIKKRKYCRKSYADYPEAQNAAQSARMALERHAKDFSNRMNQEFLDTILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA9</accession>
    <name>A0A061DDA9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769425.1">
        <property type="nucleotide sequence ID" value="XM_012913971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDA9"/>
    <dbReference type="GeneID" id="24565780"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311420"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="78" mass="7846" checksum="A68213C2375995D5" modified="2014-09-03" version="1">MAHGATSPRSGAEEVDTPATERSLKDGDAPATEDDAAGDGTVANKMRDTGNSESSSGLASMGTRAIKAAVALYMMATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDE0</accession>
    <name>A0A061DDE0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA repair protein rhp16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0312070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769490.1">
        <property type="nucleotide sequence ID" value="XM_012914036.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDE0"/>
    <dbReference type="GeneID" id="24565845"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312070"/>
    <dbReference type="OMA" id="DHPYLIL"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="9">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="11">
        <location>
            <begin position="663"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="826"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1260"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="780"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1222"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="780"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1429" mass="158093" checksum="3A9F43D7FFD8A36C" modified="2014-09-03" version="1">MADSNALAAWHTPSNVLYVNCLLDIGRGEWMSPSTANHFKGKRTKDIVKYKCIIRKHNRTAVQCQKCQRSIGKNDVIVGIPIKSIRGPYGFISLWRHVDCAVPALVCIFELQSSKASQAATGKTLAKQDGEAGTHKDNAGASKSGKDLPSSGVKTRRGRKPKVEATTKDEAAASSADAPKSDGAKAKGKTAKGKAAKAAKDESGDKEDSKGTDETGKGKEEPDPLMAQLVEHAYGFDSLGALQKVVVAKIRLAMEYPDELDEEFEIRDAVETVAITPELESLPQPPELLVPLLPFQRDGVTWMYHQEKGPVKGGILADEMGMGKTIQTIALLIAAKRDALLAQQKAQAIESGADAAGKSTSRKGSASSSKEAPQVDSQVTYKPESKPESKGKKGKKSDKKDAKNVSMLNRRGCTLIVSPLAALLQWYNEIKTKVADGYLSVLLYHGPHRKSLTHVLHEYDVVLTTYAIVEAEFRKVQNKSKIACEFCGRMYLHKTLVLHQKYFCGPTAIRTEKQRLSERKADSGSIVLKIHARLFPDIKKAVDEINAKKGEADNEAYEDDDNDSSGSPKRQKVEVEMEVEEEDPEDEDYFGAKLLKIEITDAFTTLGIPEKDVESALGSLSSGVKVFVEQLKVLAEKSNVREMKQLELLERFASSDELDMGLLKSTRVVELKSLLGHFGLSAFGSKTELINKVIVFINKMRRLSEQYSEASIATKSAENKLPIGVTGGSPDGDMQNVRVKLEFDESSIKKLVSKKKILDNEEAIPDYDATPSSMATIEADNAESDGSYEDDEEATVVRRRLRSGTTHKDKEASTSGGKSGRDMKRKRESISNTAIKVKLEDGTGDGLATQLPEKATEIKVKMEPDSANTNVYKPLKSHVKKETVDQKRLKPLPSASDETICEGSVLHEMVWDRIVIDEAHRIKTKSNSTSQAIIRLRSSGSRWCLTGTPLQNRVGDVFSLISFLKMYPFAHNFCGKYGCSCECTEFSCSDFKYCDFCGHSRILHYSYFNKRILKPILSCGYSNEGQVAMSALHNDVLGKIMLRRTKAERAKDVNLPPMHVTIRRDVLSDFERDFYEALYKQSAIKFDTYARSGTLLHNYAHIFDLLTRLRQAVDHPYLILYGPSSLAMKASNAPDPKTKAELEATVSESLPAAGSERSCGLCFDKLTDSDEFCTSNCKHSFHQPCLNDYLQSRPDDVTGDDNNVVTCPTCYAALTIKIRHTPQVEEDSPARTGSDAAPHGTSKHSILQHIKLSEFKSSTKIEALFAEISEILTTTTDKCLVFSQYCSMLELISFRLKTAQVQCAVLAGSTSLEARRNMLLEFNNNPNLRVMLISLKAGGEGLNLQIANRIFLMDPWWNPASELQAIQRAHRIGQTKPVYAVRFICKDTIEERIIELQEKKMIVFDATISSSAESMAKLSSEDLSFLFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP4</accession>
    <name>A0A061DDP4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768626.1">
        <property type="nucleotide sequence ID" value="XM_012913172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP4"/>
    <dbReference type="GeneID" id="24564981"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303440"/>
    <dbReference type="OMA" id="CMEYGLF"/>
    <dbReference type="OrthoDB" id="365071at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="222"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="654" mass="74685" checksum="6245B7D163383F97" modified="2014-09-03" version="1">MVRQVYRSRGEGGYALRQCETAPQLSHNASIEAQELKEARLMDLHGRMVEVYQRVNNCFSSSFALNHCESLTFDVEEYRARSAHLMSHLPCFEEMQGMNQVAGLWSDLFQTELSLLSNALLLDKNIAVAKRMKHHYLTRDHPPPSASQRLQASPALMEVQAAALEHTPVTEDSPVEPALLSVVNNLVTFNERLCKDCAEDRAYYDKLRDGLILIREADLLRRSPIAVRDRSKALPFLKKLCQSFDTDRCTLNLSMLFFDFYLDTVLARDDFQDTDDDSRVLRIATAAYLLACALREHWTDISSDSYLERAAHMVSGAFTTQDIMATQLDILQSMPRGFTMTYTAMEYGIFFLANIRGTYKAPRTRANKPGSPPSSSRAFNPMMRTRSGNDATSAYIRDYRLRRARNSPNDSDATMPSGSSSERGDGLRRPSMEGLGGAYGINRSSSASFRQHMDRMSSLPVVEVEPSVPPAPQGMERSVALRDYLLLEMAFRYMVENGGFVFVYHCLIKWDDMYIARNWNLFIPPSRVAAVLIFHFFVEFCGVDYRKDVVWCRRFCFRVFRMLYDCDVALWYHMFHESIRKWTNSVSQSSTRMGEMALLFELSGQKFRAAEAALHTFWSKLLFHYAERGGELPGLEHVSLKNAFPAVYRLVAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDY0</accession>
    <name>A0A061DDY0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane skeletal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0402670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769965.1">
        <property type="nucleotide sequence ID" value="XM_012914511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDY0"/>
    <dbReference type="GeneID" id="24566320"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0402670"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0402670"/>
    <dbReference type="OMA" id="MFDCCSG"/>
    <dbReference type="OrthoDB" id="371494at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23185" checksum="04916B6D5FC9AC0E" modified="2014-09-03" version="1">MISLFDCCTRGNVAVESPTNAIDAHRQVLINAGISASSITNIDVGHYQVLEPVTQTKVVEVEKEIIEEKIIEVPEIQYVDKYVDVDVPVVKYKPVYVKKEVVVEKHKHVPRIVYEDKIVEVPQIKYVEKEVEVPQIVMKEKIVEEPKIMIVEHVIPVLKVKKADHATDVDNGGQQYLDDSMTATTTTYVEAEGVEKVADRAACCTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE01</accession>
    <name>A0A061DE01_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0403170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770015.1">
        <property type="nucleotide sequence ID" value="XM_012914561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE01"/>
    <dbReference type="STRING" id="5866.A0A061DE01"/>
    <dbReference type="GeneID" id="24566370"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403170"/>
    <dbReference type="OMA" id="EYELCEA"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="414" mass="47653" checksum="90C9B6EC46CB88FC" modified="2014-09-03" version="1">MDTHSGKSEMEALNDLFSKAFAQYFMMQWCQRGYETHSTFKNELDAVVSIWPHEIPIQSEESVNQETANRNLEGEGASSQPGQAARDADRLRKFQVLKDLEYAFQLMMVACHKMHIFSSNERVEDVHTEDLKFLMLPYLAAHVGLEKPDLKQRLNVLKRCVVYLTEFIHTLIRMDAMHQRELVYWERNLGDIADERRTFRINSTKYTIEILGRMRPAFNTTEGIINFFKEANSKNAEEATLRARVLDLLHLFSFEAINLYDMIKMEIPLLERHLKEAGNPESNTVEEDKRSRPSRSKPWVIRVDGVSKLDPTTAHFLYQKLIFVPGHNLPNISLDECARIEMDMDVNTIGVRGAKENTRKDDSAEEDDGCRSGSESSSSDDSDRDSDDTKEKAAWDDWKDDHPRGSGNKNRNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE08</accession>
    <name>A0A061DE08_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-associated calcum-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0306490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768931.1">
        <property type="nucleotide sequence ID" value="XM_012913477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE08"/>
    <dbReference type="STRING" id="5866.A0A061DE08"/>
    <dbReference type="GeneID" id="24565286"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306490"/>
    <dbReference type="OMA" id="MPMKYAD"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF85">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600306" evidence="3">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="294" mass="32666" checksum="DA84C7FD3A8D0F83" modified="2014-09-03" version="1">MKAVCAFAVLLALAVPAAAWVAEDGEEHGAEDHPAGLSREQVEAKMGKLFGIIDDNKDGLIVTEELEKFNSKNLQRVQNMQLEQEMQMVDKNKDGLIDFEELSLTFPPDAGTPDDFMEGLNRRFNIADKDGDGKLTKAEMHILLNPAHDEAMLELEIKEIMLTHDKNGDGLISTDEYAATKGDDEKEDDFLEIEFKPFDLNGDGLLSSQELVLAFKEEATEDVETSLEDVIAILGTDPVDYAIWMKYALELSTSSVTDHGELLRFPGDYDLDLSDETRERKGQEGASDYPSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE70</accession>
    <name>A0A061DE70_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0405140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770215.1">
        <property type="nucleotide sequence ID" value="XM_012914761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DE70"/>
    <dbReference type="GeneID" id="24566570"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405140"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405140"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR98029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="76" mass="8650" checksum="E8BB1656F9E4B0E4" modified="2014-09-03" version="1">MVQYSIESFDAGQLDDFDKNHVNPGHADATRATAQHTVRCCLAWDRPLTIWVERLHNTTYTPNRSHAPLILNADEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DED2</accession>
    <name>A0A061DED2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0309780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769261.1">
        <property type="nucleotide sequence ID" value="XM_012913807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DED2"/>
    <dbReference type="GeneID" id="24565616"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309780"/>
    <dbReference type="OMA" id="SMINANI"/>
    <dbReference type="OrthoDB" id="365240at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596267" description="6-Cys domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="99675" checksum="F54E5ACDB0AAB4CF" modified="2014-09-03" version="1">MTLGDWFVLVALAFVSEVRMDPTSSAHGKPLKPGVYKTLQTKGSAGKLVADFTTKLTPDRPTFHVAEVDLYRGESITITCPCARATVSNFYPNELTKYYTSPPRGGSCLEAAPYTKDDIANNLLTFADERLGFLDDITDSLILIEYCKSSRRLSFLWTGEKVRALSTMYFVCLNECHRREIYNPSALIAVRVIPDQPVIMDNFIHISHIDFRPMMHDLIYTKEYSAVDQLIALCRGPEDEKVAGTWTPVEHEAMKHNVLHSDKVTPSRINPKWKDSVSLHNVSVNFKNIGGGSLVVKSRGLSSLFRVFKGKFYLSCTSSNQQLESIFHLVSNTVSVIDIIKPGPRAAGDENGEATHRQKAVQMYEYNLTHARAVALYCPLETHMLWPSSLMSVGAAKFMMEMRLMFPNTRLSKRGEHLMVIDFSNTSALEDMTLQISCKSRTQDYTSYVFALKNTKMCIFDDDMELWRPCKIILRPSEKLLVRCPRRSEREYFPLQPEDVRHGYVRVDDDYVVDKHAGITRSLVKDSRGESHKIVFSGVHGRSPIRDEVHYECSSHQRDYSTTENSPIVIVKLVGEFEEFDSAGKILIPDNSILKPTDGPKLFHILLAAGQKRRIDCSDFFVNRPATRLYPSKAWEVYDDIPRFFPGVLMDKIRGRPLYATRAMHGLTMVKQPKNAESVFEMYLDPDYVLSSRSDNAMYFLCTRNHLWDDQNSDVAVVQIYIRSNTPNHYGVSAEDALFRLDYSYPKSTYNSATFNIAEHNVVALHCPKGPDDKILPECHDVNAPSLDTQSTAVQRSSNLLQNIMEKNTRGGFKSLWYISTDMLRNESQQPVVDVECRCLDENNELLAVVYLTSRSGMAHAAVKFITVAAILAIFGTASIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEJ2</accession>
    <name>A0A061DEJ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769561.1">
        <property type="nucleotide sequence ID" value="XM_012914107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEJ2"/>
    <dbReference type="GeneID" id="24565916"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312780"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312780"/>
    <dbReference type="OrthoDB" id="366829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="245" mass="27105" checksum="FA8978CC88106580" modified="2014-09-03" version="1">MLRKLLNVLEYTATYRNSTYQKRASVLNGLTTLDTRLEATDCILQVRHCAGTLTLSDNLCKPFYNSTLPKDSENPHKSIIHNLCASAASIVGYQYPGTYDGSGIVYGNALRLCDAILAFLDVLHDDVIVPLESQLRRGHKGFCHVIPKVATGLRDYNAAVKASNERVKKPIETVLEYVKADGELCRGINDLQITETSTPAEDERTVESAVSLVEECKEVARVFSRSLTAATNAINDLNPKLKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEN7</accession>
    <name>A0A061DEN7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0400920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769786.1">
        <property type="nucleotide sequence ID" value="XM_012914332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEN7"/>
    <dbReference type="STRING" id="5866.A0A061DEN7"/>
    <dbReference type="GeneID" id="24566141"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400920"/>
    <dbReference type="OMA" id="FEETLYC"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="229"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="423"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="506" mass="57119" checksum="E438C0CF1B4C1807" modified="2014-09-03" version="1">MVLDIRYFRNSNLLQLLRASEVRRCVANSMVDSVITADEEWRQANHTYEQAKRNYNDISKRIGLVVSGKAPAVDAEGKPADKAEIISQLKKEAENHKEEIARLLNKAHDLSKTRDSLLRCVGNIVSEDTVPSADEANNLTVAHWEPSKYGWEQFIEANNIQEYRDVACKTVGEHNVKLPPWNVMSHCDVLIKIGGVNLKKGVEIAGHRGYYLMGPGCLLNMALIQYGLDFLSRRGYQPVMPPYFMKKDVMGQCAELADFEETLYCIPPLRDADRSTANEMAGQQQSAGAARDEDYEREKLFLIATSEQPIVALHRNETYSIKELPLKYAGVSTCFRREAGAHGRDLRGIFRIHQFQKIEQFVVCGAEDSWKHHDEMIGVSKEFYESLNLPYRVVSIVAGALNNAAAKKYDLEAYFPEMGDYRELVSCSNCTDYQSCDINSKYFEKDTAQRQYCHMLNGTLVASQRTLCCILENYQTPNGVMVPKALVPYMGGVEFIPFVDGKTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DEY6</accession>
    <name>A0A061DEY6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="7">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0405790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="7"/>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770281.1">
        <property type="nucleotide sequence ID" value="XM_012914827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DEY6"/>
    <dbReference type="STRING" id="5866.A0A061DEY6"/>
    <dbReference type="GeneID" id="24566636"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405790"/>
    <dbReference type="OMA" id="TNCHVSI"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR98095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="175" mass="19520" checksum="06A41C6B2FCF77CB" modified="2014-09-03" version="1">MTTHHSRILSTITSVIPEEASFLFGSLTLPYTQVLAKSELSYAFVNIRPFMPGHTLVSPLRVVKRYRDMTAEELSDFSALVQITAEALELKYGATASTIVIQDGKAAGQTIPHVHAHVIPRHEKDLENPDSIYDELEKPTNRLWTDEEMAVCARETRPFVDKVIEEGALGCLKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CYZ6</accession>
    <name>A0A061CYZ6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0101700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766027.1">
        <property type="nucleotide sequence ID" value="XM_012910573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CYZ6"/>
    <dbReference type="STRING" id="5866.A0A061CYZ6"/>
    <dbReference type="GeneID" id="24562382"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101700"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101700"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000003">
        <property type="entry name" value="60S ribosomal protein L10, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR93841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="239" mass="27306" checksum="A480A6F2C47FBB54" modified="2014-09-03" version="1">MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIYDMGLKGADVDDFPYAVHIISGEYEQISSEALEAARICANKVNWHYEFDNIAQFMVKSGGKESFHIRVRVHPFHVLRINKMLSCAGADRLQTGMRRAFGKPNGVVARVNIGQILMSVRTREALVPKAIEALRRAKYKFPGRQKIFVSHNWGFTRFSREDYLKYQAEGRLENKGVHVKWISSHGPLSKIFPQLADVNVPLDPAIVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZ03</accession>
    <name>A0A061CZ03_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0101800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766037.1">
        <property type="nucleotide sequence ID" value="XM_012910583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZ03"/>
    <dbReference type="STRING" id="5866.A0A061CZ03"/>
    <dbReference type="GeneID" id="24562392"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101800"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101800"/>
    <dbReference type="OMA" id="DDHNAEN"/>
    <dbReference type="OrthoDB" id="423263at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="242"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR93851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="459" mass="52442" checksum="F065E8BD1B10BB20" modified="2014-09-03" version="1">MEDISLPFMRNIRLGMNEVVHEQQHIVHEQENVILEKNWLLPERREVVSELTEHVDETVEVDYGKSLESAHSNPHYSLLVDKIREYKLEVIPGPFLACVQKGWFINCADKQNDIKGVLDWEIRAIVHELSERREEFDEQNEVETIIAYKKFITVNGSHYGNEKEFVKKYFNFKTTKKLIDEHNSNPDKLYTMAYSWASEFSDSELGIALSTNGWSRPMYMYENGRFIDTSMYSGSKNVDDGDIVHKDWRNTNAIGPVVDQGSCGSCWAVAVAGLVDAYRAITTGQRLQHSVQQILDCTSQRYNCVRGGNQEKALVYASTTGLCIEPAYPYLGRKTACREKTCGEKFKVDNIKRLNARMIQEHLRSHGPVMIIIRLSRAFMHYSSGIFDGSCDSTLMHSVLIVGYGENTKRKTKYWIVKNSWGDRWGDGGYFKLHNLPLSPAGTPLFCGVDTYAFGLTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZS4</accession>
    <name>A0A061CZS4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766099.1">
        <property type="nucleotide sequence ID" value="XM_012910645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZS4"/>
    <dbReference type="GeneID" id="24562454"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102420"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102420"/>
    <dbReference type="OMA" id="TISPGIM"/>
    <dbReference type="OrthoDB" id="360160at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="433" mass="48209" checksum="7078265C0350FD50" modified="2014-09-03" version="1">MRSVQRELSSPSQCSYDYESEFGLDKVIRSGSTSGGSISQRSTIDNGVGDVYEDLFLLQEIAFDSPEIENRLLGVITHVKHCNSYSFPGWFFQFFVASFHYLLIAGFVLLIGVIAGIFMSSPTGIIGSFVWHSSTKAASASQSKLFVYHNPGTQSLSVEGTLYLSHHFMNPAPFTATLSSLLSVLYLPQDFPLIEQVDYCRNETEWTKKGNAGAKWLKFPNSRIFQESSVAQSPRTFTGQPVSDVNGTPPAEGEAVGAVDEGNLITVHSVKQVWRGYWGSDIQVAESSMFDLFTSYLMLGNRLHMVANVHWGLNEVRYMISVKQMITRNAENSELYDALLTDCRRGAVLLQIASANQRFETMFFSSDKPPHKFIPVSVGCQMPVPGTAGHDLRAAWRDQHDDFATHYNILFNMDAVADAWYPLRPLRTSANTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZU9</accession>
    <name>A0A061CZU9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0104450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766322.1">
        <property type="nucleotide sequence ID" value="XM_012910868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZU9"/>
    <dbReference type="GeneID" id="24562677"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104450"/>
    <dbReference type="OrthoDB" id="366735at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="26962" checksum="1B97CAA105C4FB5E" modified="2014-09-03" version="1">MVGERGLIGSWDSAYYTNPFDPCNLCHKSRIRMGFKETDLPSSQQTGSILSTILTFCCGGSDPLLTLSAYLNCLTRLTPSTTGELVSYFHNFGVELHGYALKSLSPLGISLSNSHPNCPDWDRLDGTDLKDLRGIRGSESLNSTHDHLKSPHKQFGDNLGHLHRHPQLLPTIYHSHALYPLVFDYTIFHFLNVLPCSQKFRLPRRPTSFTSRQYSFTGRGYSYLATTSTASMTPWANIVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061CZY8</accession>
    <name>A0A061CZY8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroorotate dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0103050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766169.1">
        <property type="nucleotide sequence ID" value="XM_012910715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061CZY8"/>
    <dbReference type="STRING" id="5866.A0A061CZY8"/>
    <dbReference type="GeneID" id="24562524"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103050"/>
    <dbReference type="OMA" id="IYGTDTR"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009220">
        <property type="term" value="P:pyrimidine ribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003652">
        <property type="entry name" value="PRK05286.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="107"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR93983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="443" mass="48578" checksum="30A8DCD10D4AE47B" modified="2014-09-03" version="1">MIYRRLVLRVPRLSRGFSDAKSTEERVQAELLYQRRVSRWIFRGMCVAAAATGTVVCLRNPESSIYNVVMPFIRTYIDPENAHKLSLMALKLGLAPVDYSVDPPIIQSRVKDVVFFNPIGMAAGYDKQVEVPLEVLRLGFGFIEVGTVLPKPQEGNPKPVLFRLHGSKALVNRCGFNSCGLEVAVERLKRVRQKQADDPLTKDFMIGVSVGKNRTGDIIADTVETIKGVAPYADYVALNVSSPNTPNLRDNQRREPLIALIAVAKATLDDVKAHNATFQNTTKKVPLLFIKISPDVSRKELEDIADIALVHNIDGIIATNTTVSRPDEVTEDCKIAGHPAGGLSGRPLKKLSKKLVYDLYELTHGKVPIIADALEMVEAGASLCQFYTAMVYEGPGLPSRIKNGLAQLLLQKGYSNITEAIGAEHRRRQAATAAPAPATTKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D082</accession>
    <name>A0A061D082_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0103897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766264.1">
        <property type="nucleotide sequence ID" value="XM_012910810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D082"/>
    <dbReference type="GeneID" id="24562619"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103897"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103897"/>
    <dbReference type="OrthoDB" id="360186at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="399" mass="43472" checksum="236F138A3CDBC63D" modified="2014-09-03" version="1">MSYLQNEIRVVFTGPSNRFFVAYKPYGWFLTTPFDPRLGEAVMAPVLAAKLGVPAKNISFPGKLAARESGLIIGCTDSAMHNKIAATLKSGQCSMSYQCIVHANRAANGALVRRSPFSHAFACYNHREGVSSGVARFDVRTQAKVEPLKRLSALPDERLRSVLSQFLARSRVVSAHDVSVKRSGVTECAERISDEGEPGLDDTGSCKHHCAPSDDVDSSSTNASTHQDSGACSANTADERVAVTDDKSPTTDSRQNGGYSFAYIMENLRDYLERTAEYGTAVQSGRVADGKQAFRDNKARRSALSQFRHVEIVTSSHLVNRHMVEVLSSMGLVVLTGSPHQNTTKIRATVESACLELCALQFPHPIYRDRVVEARLHEADPVVPEEWVRIALTSSSGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0J3</accession>
    <name>A0A061D0J3_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0100010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765858.1">
        <property type="nucleotide sequence ID" value="XM_012910404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0J3"/>
    <dbReference type="GeneID" id="24562213"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100010"/>
    <dbReference type="OrthoDB" id="366456at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="379" mass="42020" checksum="635A01D7B2F52579" modified="2014-09-03" version="1">MFTGAGIYELLTTPIPDVAIEMLLDGDPMKNGINLVTIISLLYDALCNYFQACHIYVPPKPRYPCTVRDMLSWLSGLQYTRVADKLPGHCKALLNRRCHDSYTPNRDDPIMAKCIGELPYTIATTCSHSTALLTAIQGNGHGFDLAAYPYSVDFSNNRARLHYPADPDALFDMLREIVCRLCKVLYFLYSQCCRSTARVKGWRECAYGRQVQSHHWQCKQIGTYSSTISNTTAATTTTTTSSTSNPGCPPTSPLQSFLCDCCHGLLPHALTTADMTIECANCAANQLGQQCLTPMGFWNLGFAASISGTGWDLVKRLGDMCRNADSCLFVLCRTLFYLRPTAPSSLADVFALYAQVLRKWDSHDWQEHRGGTCSDASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D0V4</accession>
    <name>A0A061D0V4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766622.1">
        <property type="nucleotide sequence ID" value="XM_012911168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D0V4"/>
    <dbReference type="GeneID" id="24562977"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107360"/>
    <dbReference type="OMA" id="CDEYNER"/>
    <dbReference type="OrthoDB" id="365794at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056353">
        <property type="entry name" value="Microp_dom_apicomplexa_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23527">
        <property type="entry name" value="Microp_apicomplexa_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microprotein" evidence="1">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="299" mass="34237" checksum="7B4D0AD62CAF63FB" modified="2014-09-03" version="1">MSNCIKHSLRLIRLLYKTYNHRDIRNVCDFELQYGLLCGEDNILHFACYVCQEIGLLAGTADGAIQSDGSKTASADDIKQLLTELEVLLNELISRRVEERRSYISSICSKQFSNVGLVYGHARGAGPLMRPWCSTPAEELINNEGVFQEYALPDDTVNSIRILSSSLCDEYNERWNLYLVRFDALLKVFLQSKNLKDNDALRTLLLVIHHWRNGGSTRLKKFNIYDVYNARRDVLEVRKAYDGSPPLSLVKLYSEHSAVPPEGQLTSFIKRVQISEPTHRLGIPEGFSTKRFYKKFSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D107</accession>
    <name>A0A061D107_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0108040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766692.1">
        <property type="nucleotide sequence ID" value="XM_012911238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D107"/>
    <dbReference type="GeneID" id="24563047"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108040"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108040"/>
    <dbReference type="OMA" id="VVFEMNT"/>
    <dbReference type="OrthoDB" id="361987at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595861" evidence="2">
        <location>
            <begin position="23"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="413" mass="44291" checksum="D6A7C7A5639724DB" modified="2014-09-03" version="1">MVSLVPLIFIAVVLQSWTAALTDSKHRRHQEDASHADGSYTHTAVNRSKGGLQGGGRSTHQHHSHAETAEDRHRGYRKLGALSKQVSLLQAAPHMLVDKTADGTTVTNPGSQTSYSQTLASASSTAAGVNVEPQGQTAAASNVAPTQGANQIAPVNGLANPEIAPDNAEENNGPTDFACKFLWFLFKECNKPAPATQDANAQSNAATDIADDQQPVPPVVSSSCTIYGTTVLSLDDFKDPEENGWILVNDSNAPRITHNKQVNLDKPAQLQLKATLCNAATYEATIKLGVDSSGGFIIRGSDQDFVVFEMNTLAKTATLKSINGAYQDIISEVACVSCCSLVNMRGRTKLTANLYRSERRNAAIFFRQIDILIDGRKITSTSRMPYKSSGYFGFYIAQGNATFGDLSVVPINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D192</accession>
    <name>A0A061D192_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0107120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766589.1">
        <property type="nucleotide sequence ID" value="XM_012911135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D192"/>
    <dbReference type="STRING" id="5866.A0A061D192"/>
    <dbReference type="GeneID" id="24562944"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107120"/>
    <dbReference type="OMA" id="CFHYFCE"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR94403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="355" mass="39083" checksum="962DCDCBCAA4D4CC" modified="2014-09-03" version="1">MFQKRNLAALRNRTPVPQPEAAASGASHDGATTAVRLAERRTGRKICVGSTKDAAATVRADVGTYEPDRSEEVKSDQRATSTYEIDTEASRDHRSILERNAEIGRKLLNEELEDGVYRGRGAYRPVMNIREGSIAASKYTGLYGPVRASSTNVRTTLRIDYQPDVCKDYKETGYCGFGDSCKFLHDRSDYKSGWQLENEWEQAQSAKRQKLQEKLARWQRKVQKNLADPEAASSGSDAGHAASDAESGSSCDSSSSDDDSDSDSAPAEKSKYARALKARARNLNIPFSCLACRKAWRPEMNPIVTTCGHYFCESCAIRSYSRNMKCAKCGVSQDGILNPAQAVIKLLASMNSECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1D2</accession>
    <name>A0A061D1D2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0102510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766108.1">
        <property type="nucleotide sequence ID" value="XM_012910654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1D2"/>
    <dbReference type="GeneID" id="24562463"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102510"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="94" mass="10815" checksum="2285912D65A88114" modified="2014-09-03" version="1">MSEQKFQRFLTRISFSRPNSFSLTLSSHLKKSKQLEYLYNVDVEWLAQSKIILSIAIEGRVIRPPESHLAAAGKLLKQRFKSVTICSTALYIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1I0</accession>
    <name>A0A061D1I0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0102990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766163.1">
        <property type="nucleotide sequence ID" value="XM_012910709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1I0"/>
    <dbReference type="STRING" id="5866.A0A061D1I0"/>
    <dbReference type="GeneID" id="24562518"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102990"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102990"/>
    <dbReference type="OMA" id="FLYTSHC"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="122"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR93977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="629" mass="68345" checksum="B05220C4FF1CA8CB" modified="2014-09-03" version="1">MRTDPKKVAAILGEERLELLYLGTEHLAGDSSAAVRREVQSAHTGFGERDVVADGIYRNLQHILRSLKEKRDISPGHLAAELRDTQSAYNGLDPIHRNYINGCAGVDDGVATDSTSGGNDTVDRSLKGSVDVILVPLLRLLMRTGRFVSTSCCSGRVAIFECNAEHATAATKSASDFGRAGRFLYTSHCHLDHKEALSAASAVNADVKCKRDCYHKEPSTYSANEEPKPAAEATSLDGSARHPCEVVLKFEAFVLHVECASMQDATTLLQLVRGCGLKKSGIITCTKRVIVSITGSNILETPIAIRHYIRGNYGASTESGVASDGVHGPNTPLGATFQAPSNDIGTNERVETQWLVSQDQFMYLLATCNRKLTGSIRQMLRLYWSCVNHFGIDILQPFSIRNKDFASGGMKDKSKSGQRGCATEKDSRRPRVHKNVPHTATPTRLAKREEYGLCNAPAISAYPATKSSLLGNAPKEGVTEDPSYICTWYSQSSDAPAYEHDPSIRPYIAVKAAQYIKPLKTRLEQHRLYDKTRKIVTNLSVSVVGINAASDNATSQDLDPPTHESNCVSASHDVPKEASVAAFIPIVAVKDDKLKSLFDQSDPLVDFVFTVNGAMQCRLTATEAATADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1J9</accession>
    <name>A0A061D1J9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0108160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766704.1">
        <property type="nucleotide sequence ID" value="XM_012911250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1J9"/>
    <dbReference type="STRING" id="5866.A0A061D1J9"/>
    <dbReference type="GeneID" id="24563059"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108160"/>
    <dbReference type="OMA" id="KPNIMES"/>
    <dbReference type="OrthoDB" id="372890at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="453" mass="48561" checksum="7CB8E06EBB5EE9D9" modified="2014-09-03" version="1">MASIVGVACHFGLCRSSKRANRLFPGGQNLGAPAAPHGASQEGYNVCVAAGCNQFESDSSNPLQHQCGMHTVCKRCPTPGVSNADICHLFPPTQGRINVIEGSMDTTSSGHHGAYEGGHSEDDEGDEGSFLEINSFDMKFRPSTSNADIKSYARSCAVDRDGFVDVAVRVVLQWYKVPGKESPKEAAYEEEGEEDGMLEMEPASRLSLDDLDYSSDDEGGSFLEIFPQLGEKLRGMFSSDKDSDDDGSDGGDHGAIGMVVHGLAAAGHGAYNRVKRLFKSPKLQVHYSVSHQTLSSCRQSQRWEGSLHGSSLIFTSNQNIRILASNLQSKFFVDNLKVHVTCKDCEQLQSRSCVQVHCAQRQPPARIHALRSFTHPPTAPTLQPIAMHPPPAAGIGHAVPPIAPAAVHTAPLNVYDPNTIVAHIASHSGNFADAPGVLIATIVILLCTIELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1S2</accession>
    <name>A0A061D1S2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0103925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766268.1">
        <property type="nucleotide sequence ID" value="XM_012910814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1S2"/>
    <dbReference type="STRING" id="5866.A0A061D1S2"/>
    <dbReference type="GeneID" id="24562623"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103925"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103925"/>
    <dbReference type="OrthoDB" id="366291at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="587" mass="64834" checksum="80DB39C0873E6D67" modified="2014-09-03" version="1">MVDPTMNARQGSPMRCCNPRAFRRNASPVFRQQFISDNGKMKLSMPMSPLHYITASGYYANDLRLASPNVQMDAQKCPQPVPYPMVYDQQPMQMGSIGVVDACYPQRMESVGSRPPTPNMQVFVQQPQEYRRASAQLGGAQNVVVEQKSNVSLGQPSQRIELTDILLVLTRIEKKVDHLQELHEAMENENKEKNAMFKPKSGEQTAAQLHVHCTEHLVQQIKPASLEKLGSKLSVSSETLSKSSSGKYSSESLCDRPMKQLSMPSITQELANIQKPGSKVFDVSNELRKSNDMLEQFLATAGAIGDVDDQEGALQHENLQLSQAMKHIEAGQHPTQEICDQEGDDQSKSETIESYSAAKPIVSTVSMIMEDQAKDSIENLEKRFHMLIKTLEHNRGDNARMNGQTGALEGRKENAIEGAKQPALTAQQLQAIAAGGFDAEGGFNMGEIALRGIIGELATREAEARTGSELQTRNIQLPAVIPTENTALTLQSQQAVAPVVPQDMGFSLNEHMKSISTEHREELQQAEQALRTQVSNNSRSGTEEENLVAKSSNGEMDSQNLTCSMLTEDYSRQYSLEHADSIRDLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D1V3</accession>
    <name>A0A061D1V3_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0104160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766293.1">
        <property type="nucleotide sequence ID" value="XM_012910839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D1V3"/>
    <dbReference type="STRING" id="5866.A0A061D1V3"/>
    <dbReference type="GeneID" id="24562648"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0104160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0104160"/>
    <dbReference type="OMA" id="DKWTLFY"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060327">
        <property type="term" value="P:cytoplasmic actin-based contraction involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016814">
        <property type="entry name" value="Profilin_apicomplexa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022993">
        <property type="entry name" value="Profilin_apicomplexa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Interaction with Pro-rich sequence" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR022993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="164" mass="17955" checksum="C8C18E84561F484D" modified="2014-09-03" version="1">MADWVPTIKQLALAENACFGCGIANAEDGELFSAADIDHEELCWDSVYRDPYEYEAADETGATVKHHIVEKATIMEVFEKKHSSIGIFIGGNKYTFASYDDDCQSGEYTFKCVSAAKTKGGAHLVMTPGGYIIICVFDETRGQNKTTSRMAAFALAEYMAANGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2B1</accession>
    <name>A0A061D2B1_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0110410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766929.1">
        <property type="nucleotide sequence ID" value="XM_012911475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2B1"/>
    <dbReference type="STRING" id="5866.A0A061D2B1"/>
    <dbReference type="GeneID" id="24563284"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110410"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110410"/>
    <dbReference type="OMA" id="APITCIY"/>
    <dbReference type="OrthoDB" id="361914at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="58059" checksum="713511561D60D102" modified="2014-09-03" version="1">MAKPVPARQDSGGSTGDVEDSRDVKSASGSVSEELNATQVSFASARRTSGEHIAHHRSKPVDDRKQWSAIKSLMKKLNTLSEPMGDAGWGPAYEIASKPTRKGPTMGLFFAPAKRPEYCSLIMQTPDSMERYSFYGKLMQHMSCAPYAITTVTYGHVVGIGRCGLCGTQCGKVVVYKLDTFERIFVFDTLYYYGKAELPMVQLESIPADEDSVVAPNAFEINALKLVKTFENYSTMMVVGNQLGHLLVVELPSMRLLNIIYYPKQGVAATPEPPTSAAVEEEEEDDNEYEETPRQQRIQTVVEMGDPSPYISCLKVQPNVNDVWVGYGDGTFAVFTIPAGLCKKHVPADSMEKETNSNVEIDVRWQRVTSIHFSGMLDLALVVYGNIRVDVWDSRTYTLLKSLPASILTCDSSLISSMRVYEGHEKMCLLFIGSMEGSLIMRKVQRHPTHGVSWSLLLNLLYDIKFSATPGEKHESTHELESIDFRGAPITCIYPLLSYNAVIVGNACGAMVAAWNVLKRIRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2F6</accession>
    <name>A0A061D2F6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0110750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766964.1">
        <property type="nucleotide sequence ID" value="XM_012911510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2F6"/>
    <dbReference type="GeneID" id="24563319"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110750"/>
    <dbReference type="OrthoDB" id="365966at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="207" mass="23255" checksum="B2EB268F674D8899" modified="2014-09-03" version="1">MKTQAHCRNTGKCAYINELDKRHIHLGTFDNTRDNGPLVITVRKSKLEKRLVYAVTALSKVLTGNFWMSIGIMNSKEHQKADGQHQKYFNGILTKEFMERTLRFGQSAHGIETLSFVPSNIKYTVEDLKRLKGYPDGAPSGITPSGEAVEHEFKIPEVDGPEMSKGSIIINPEVDAGNYYLEFAYGNPDKGPKMVCFKEVIVKVVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2M4</accession>
    <name>A0A061D2M4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0200050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767034.1">
        <property type="nucleotide sequence ID" value="XM_012911580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="24563389"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0200050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0200050"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1745"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1807" mass="201194" checksum="C690BAF581CC27BE" modified="2014-09-03" version="1">MGFLSGVLSNIHKHLGQHKNEINIAIEALNTNKHLGKKGFSVAIVKVVEGVGRYNDAVRNSNNHVKNKITDFDREMKRLKKTVSEDLKNNSAAGAGRIVQGSVDSADQLVETCLSNANKFNKSLDTAKHENVRNAINDCNSIVRDDVNKARACVKLETEQFAALSSKQQEDRKVMREKIERCLTDLGTCVNDSIKKKVAKLVEDLGLKVKEIKRQLVEIQGKLVEYIRELTTWIDKAQPLINSAFEKVKEILEDINDGNSVKKPSLIKSTVTQIEGAVAMLKGAGEDAGKVVKEKVSAALKQVKEMNDALKQDLYSVKQEIQKAIVNHVKKQIKTPYDELEGNVKQDLTTLKGNIKSEVNAIVLSSNEFSDQFTATQHAIDAAIQKVHNKVNNFKHLSNFNTFASDFDSSVPMLTSIGASGNDFLQSLSEYLNLLCKDVMGPSSKAMEMIAAGIETSIGTHRLDETVIIADKHRKSLQQLLDIDASSSSMSALKILLGKDFDAPEFDLQKSATKIRRLRQQLTVQHPQSAKLKKQDLIDILNDLGNIAGAVSDHSEKVVKAAMKAIKAKVKGEISSATQIILNEAGTIKSGVQNGKVGEKVVYGEHDGDRQDVRGLKALVNQFDTKIKSALSTFRDKFESDFFKMKEPSSGEHDYELGPNLMKTFKTAYDALKDGKLKDDTFQKDVDEILNKEIGGTILAGGAAADRISNIEKNKFPNYDAQVNQDSLGLENPDQLAGKLPKAITEIKKQVEGAVKDVVKFYSYAEEDLKKVTTALQQLCQAVKAAGDNAHSDLKQLKETYFNQSEFVNGGIRIIKYQLTNLQEDDLTKAINEATKFLTDAAKIREQTVGSLKIDVDGQVKEVKRQLTSELDKQYITTMALQLDHFADRVTEHLKGLPEAIEKDKHTGFKGFMEAFEGKPEVKPRDKYAFEAPTVELSKLEAFKGAVTKPHNSKKEEFKTLSQEFKKWYINLHLYVNKETVRVNNEENSKKHPAGTDVHDYQRRLLAMYDRFNELMSHITNANRYDHQISGLLDRLLEALHDLKPDGFSQPSTPIIDCVSSGFTSFVGLLRNVYISAYDTQTFDGLLCTEETKTDDSGQAKKLTQLTDHGRKCAKVFLTLLCTLLSSLTVLKHNCKSLTKQQINKSTDVGRQFAELGFRVSDDGKQNGELHDTSLITGEYVANSLTFRIKNANNIEHLKTCQRNKDRLTNNVSIFDILKCIYHHFEEYNEVCHLASSSSKSPCSVYEMLVWLTGLPYTAANSVMRHATITELFENPDKQVTDGEISGTLVGDSPIKARPYDITFDRVIRAIDHVCSKSYDVLTTVAGHGDADTTYGSDFCNNSLKLRYPSSGEDCFQMLLDVLWRLLPALRYLQMQCVLNDKYSGWANCQYGKGVPPSNWPCSDHPSDETKCQANCQANGKPTCRPTSPLQSYLHDCLVGYLPHRVTSIGCKSVCSNCPRNKPGMPCLTPMGFRGFSGSARTGKDIYEMINTFFGTGLISSVLCLVPKPPSTLPEHFSFASSLVKDWQYGGSSKENDFQSCIETSIDKLSIRLNESRSKFTDTLRDVYGSSSSSHSAQGHVAAYTDLASLSRNATCSGLDVQCGPYLQSTCYDAYNYLAHKHTDTYLSWALYLPWEFWNYLKSLLDAFQQIDCGSFGCRGCPCKPGSHGKEANCKCNTIVGCRGVAPTFYSYGFTLGDAQALMRTDSVKNCANFVTQLKALLNSNYFRTLFEKCDEFIFTIRAPFLWMTVALWSLSIFYLICVMVGRLDVLHIRSHLRTPSSHRITAQSLLAAAQVGRLAKISYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2M7</accession>
    <name>A0A061D2M7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA cleavage complex II protein Clp1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0106260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766503.1">
        <property type="nucleotide sequence ID" value="XM_012911049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2M7"/>
    <dbReference type="STRING" id="5866.A0A061D2M7"/>
    <dbReference type="GeneID" id="24562858"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106260"/>
    <dbReference type="OMA" id="CILGVSY"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="125"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR94317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="535" mass="58574" checksum="E8387E9E4BFDC583" modified="2014-09-03" version="1">MASLPIRTYTLAPFSELRIVSHDSHDGIPVLPSVKLLNTPAAAADLLPNMRGTAEIYGRELAPDVDRTIEEGEKLAVFTWVGCSVQVKGMVEQEYDGEDHAMKEYLNVANVLNAERELASVKRTQGPRVLITGAPSSGKSTVAMLLCNYALRGGWTPVFVEADPRASTDKRQIQFYPGTIGATVVTNAAEMDSKNPLVYFYGYSGAQENEKLYLQISKSMGASLDAMMENSSQTQPHSRRSDEVSDMGKYIAASGMIINAPYSANRDLIVKLAEIYSVSLILVIDSPSVRQDLVRTFAAIRDGQRAATPLTGVRGDVAPGALGNLAFQETPEQKAHTQSDLNETQTAFDGADASDDKATREVTVLAINKLEGVVPVDLERVKYLNSRCWKRYFQRTNAGEMHVIRFPMENVKLVVLETSVALSKDALPTDDTGYMTRNEVYASMWNGDPFSLTNGVLGIPAADDATLIPYCNLLGFVLVRKVEERAQQPDAETDGEPAPRTYVMEVLCPAVYSPSSLPAYLLVAGNQRVMRWQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2P8</accession>
    <name>A0A061D2P8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0106510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766528.1">
        <property type="nucleotide sequence ID" value="XM_012911074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2P8"/>
    <dbReference type="GeneID" id="24562883"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0106510"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0106510"/>
    <dbReference type="OMA" id="VSNFEFC"/>
    <dbReference type="OrthoDB" id="365431at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600548" evidence="1">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="333" mass="38490" checksum="11B949A2166A56B9" modified="2014-09-03" version="1">MFGLKRVILTLVTVLILHISSATYIHARRHCALGYTALRPFLRRPTVTKRTSREEKKRRSEFHKQLHKELRMKYWERLDPAVNTIIQFQPERQAPIDPKRAFVVQEAIPRLVKLTEQQTNCSLTAEQSEAFDRRAGLKLLCDIKAVFSFIAETINTDGHFKDFKLMASQDQLPKQHADVNYIMSLLKVQTEPEPSTECTEYLGHLAQLAELHPIMTCRIPFPCVLYHQGLALDEEKLPRAPAQSPETCCENEERFFRCRLRHFRGKRHADKYCTTMQKTLNKVATEWKRDDKDAFIDELEVAQQMAPKALTAAIHNPYKASQSVVPYCEIAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2S9</accession>
    <name>A0A061D2S9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0202380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767267.1">
        <property type="nucleotide sequence ID" value="XM_012911813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2S9"/>
    <dbReference type="GeneID" id="24563622"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202380"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202380"/>
    <dbReference type="OMA" id="ERICMRA"/>
    <dbReference type="OrthoDB" id="366438at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="640" mass="72055" checksum="8F13551A747EC6AD" modified="2014-09-03" version="1">MEAASVVMHRGSGAAVLGRKPDPASALSTASGLIRNYDYLEALSLLRDAEREYAECGDSEVLSRFSELQAEIHVLLGDHKEALRCLQRSNFSRTSAIAAARIALHVKCKSTAADISASVCDLLTRCMSSCSDERRIPPDTHALLLEWSRRAGRLSHLHDWTVRAKRRGGGIRFFRDYPSLTPYLRTILLLQREWLLDGIDSQERVTPYVTLEPLRYVDPACDSGAALVRSICDGVEHTLQRERHFVFYVDSLPLALACLTRQLRELDGSTLDRLHTKRRVDVVEGDCASRDAESPEERVFANNNVTDRPAKAMRLNPTNCESRSRRRPILTSRRGSARPRKRKQCLPEGTGRLPRGPLPSRSMERRVSRVISERICMRAHWSFFELALLFFEVLSRYHHLLGCRREMYTLYLCLLLHYIRRGLAWRYESQSMSNGCLFSSAPTVDVRLLNDPDDACASFRQTLRRCGVRVLCLMADVMRCPPSALEDLCDAIPIDCPTDLLNEAFGHLSSMLLLLAHPYGAQHGHGDVVLRARVLFVMAKRLIRENLPRRGAVLGPRCSRALRALKDIEICLQTLRVSAQALSFAEMRRNAHLVLCLRHRGCGVNFHSSLTHGASALGAAAVDRRWSSVARTLQGYVMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2V0</accession>
    <name>A0A061D2V0_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BBBOND_0107160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766593.1">
        <property type="nucleotide sequence ID" value="XM_012911139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2V0"/>
    <dbReference type="STRING" id="5866.A0A061D2V0"/>
    <dbReference type="GeneID" id="24562948"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107160"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107160"/>
    <dbReference type="OMA" id="YMNIHTW"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="819"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDR94407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1127" mass="127310" checksum="2D067F3DBF2B2DF8" modified="2014-09-03" version="1">MGSPRVVDHVTKHVFRIALKKSERTPAAQKDAGQGNERLYVGQFYTRITGVASTEDVTLDAESIDDVARSAVFACILHKKNPLTMLCDAFVRCTQVKGQVEANKDPFGLPELSGDGKLLPGVQAQLRELLATINRVIITNSALLMVCPMFFNLEDFVAKQDLKKEPLDVADQTTRCKMINEVMVEAKNATYMQQMLDEMWQNDETAALGEMYSFFSKMRSDAVGRPIGEKPVTELSALTNICGSKLGASLVVMWLLKEDTAGITWRSSGIQREIATLLGRILSASPMNEEALETAKMTSPNAPTCKNAKNIRELNFRGKRDMASIRTSFAHLREDHETYIHMVSNLLKAILRTDFKTRTDFMAIIGQLVAYNATKRHLSRITHVEQPPITLDDTFKRRRIVMADSTFGASLNVMWLLLVLAEGITEQKVDSIDPNFCQIGFYAKKKTTISGSSENNIDESRIREMSEMRATLDTMIGFLSSSSAGMGDETQLMEALEKQHFDITESYNAKFITQIFWATLHGLGMLYQPCLQEFLKILIFTMEVAQNSADPMNDESLQDVVSHLYMWRCVMQHGKFLEALWHYINISLQFFIKCALSEMWEKASTTPSNLKGTSLCVQMVYSFASGKLGSPNEVPAKFIVLPVDFIDIILDVIKHISIVRLYASHVKPQDTDLLEFMDFELVMAACIFIMKADQSYIKNLTLKCDTVSSIILNLCKSMGVEKFGNSPGAKQHLVDALTNIFIASQRSDYNSRISCRLNVIHTLTKLFGIEVYKKSFVAHIIANKENFVQFMHLLLSDTTFIFEEVVTFLSEIRRRELAGITDEPQERTEQNEPSTSSGQSAQPRQEQREPQQPQREQDDDQSLDPSLQDGAIDPNQLKNMPFNELQDRTSNFVEYGSQITTLLYILCREFPTEITGTSVLLPQVASCLGCCLDNLAGKGCINLKVKNMMQYNFQPKNWLTSVVKCYVALYGGENPQNSEPFMKAVVSEGRYFKPSNFERAFKIITREMLLVSKDRHAFFNMSQKLCQYAKANNTLYENAMNAEMPDEFLDPIMMDIMEDPVLLPTSGIVMDRKNIERHLMSEATDPFSRQPLTKAQLVPQEELKQRIDAFLASVSRSTDITEDIYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2W7</accession>
    <name>A0A061D2W7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0201150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR94958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767144.1">
        <property type="nucleotide sequence ID" value="XM_012911690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2W7"/>
    <dbReference type="GeneID" id="24563499"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201150"/>
    <dbReference type="OrthoDB" id="366824at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR94958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="507" mass="57258" checksum="4F83BF291E43DAA1" modified="2014-09-03" version="1">MAPIRSYGRRWVVALFGFYAVGYNGLAGASPMTDEQPGNVETPAKGIAFYADNAEFYRRVKRLETLSRPQNQLWSQLMSVLLNLRQSTISPKIKEAIAEECRQLIRDIEDITSLHDRYTELREIINEYSAVTRCKKRKSLTRERYAELQNALTNLEEQFKDIEQVASEILRFDNAAHFRAVVRQASIFIRQHTGQGSTQSDDEGSSGLGGDKQATLESDTVNSIGVRPNDLHRNDPRSDEGNETMRELLNDRSLFKTLGYVNEIAKKIDAILKGPLVDNFKLHAAGSVFNRYNAVILDVQRDYDMRYDEIRDLTNAWNIYKRYAYINDMLQEMDPQSTKASRLIDEQRQLEVAFEEYGTIVDVASILRIDWDAWSILRILRFLEAEMGQTQANHTVSIPQPEHNEVNETATETAMPNDSNTTPNTTEPKEPTQKPEPKTTKESTPEPSERHVTAEGEAGGASGGPQETGNLPNTMRKTKRDSDKSGIVAMGTMVIQIMVATNIMVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D2X6</accession>
    <name>A0A061D2X6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CDGSH iron-sulfur domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0202830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767312.1">
        <property type="nucleotide sequence ID" value="XM_012911858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D2X6"/>
    <dbReference type="STRING" id="5866.A0A061D2X6"/>
    <dbReference type="GeneID" id="24563667"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202830"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202830"/>
    <dbReference type="OMA" id="CRCWQSH"/>
    <dbReference type="OrthoDB" id="449252at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR95126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="113" mass="13150" checksum="13791002E3F08A04" modified="2014-09-03" version="1">MSNPLECYEKLDFNTRQQPLYSHVIENFPKSDRPDVVVRLCRCWQSHKFPYCDDTHKLLVENGDDVGPFVAHIRAERSKKREYVKLRQRETVPGVSRPSALHRMPSSRALALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D350</accession>
    <name>A0A061D350_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0108200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766708.1">
        <property type="nucleotide sequence ID" value="XM_012911254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D350"/>
    <dbReference type="GeneID" id="24563063"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0108200"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0108200"/>
    <dbReference type="OrthoDB" id="365660at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010884">
        <property type="entry name" value="6_CYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038160">
        <property type="entry name" value="6_CYS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07422">
        <property type="entry name" value="s48_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51701">
        <property type="entry name" value="6_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001599990" description="6-Cys domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="6-Cys" evidence="9">
        <location>
            <begin position="823"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="952" mass="107408" checksum="E15F00FC0C2E5B37" modified="2014-09-03" version="1">MAQILRAASVICAVWFNWIAFVDAFVCDFSRPYDLFRKNAIVTCDMDVSVLSSATVICPRIVNYTEYVWHQPIKSDEKGQIKTNVGGKDKFGSLPISDLLVTESLRALLWIESKEFHTDLHIELGDDDIYAITKNRLAFICGPKDLLLSDALLRHLDRLNGFRLIEEIPWTAATPLIQEMSKIGKGLGVFFLNRRDTALPFQGCGSRPSPLFAPDNVVSEDEFTGTRSCVADPMSKSPIGFLCEGRIEPSDCFRSLLDENGKIVIAPLPHSYKHVYNRGKWVVARYFNDVALPRFNGECRCIDPGTGHVKARIEIRSKKEYVCDIASMIEQPDKSVVDGPRCSVLIHPGSTLTIRFPTEGLNPASTDEKLSSAPRSQLLSINEYETELLPKDLTTLRQQTYYHDPESYNEISYHDALADDVLELDRSQIAKGEIRLNYHTDRPLTLLGGHNSFFFHWTLKSRNKHVPDKISATINVSFALTHRYSTAGCDEGEPSVFDPKISYNHCSVKYMRNGIGSVYECLYNTNLDRIQVGIRCRPNEELLPNNCDNTAYDLYYDRIMQLPQYARNVTPTPIPGFRVFEIKSDTRSDVYACICADEHGYEKSRLVVERNKESFHHSNVREAATSGSLQPYVLLPWTETGLSSKETTSKLSLILHNITKETVVLALGTTLIIRCGVSPELRHLEYSGKITTTLLPNDPELFYYTVNNISSTPELALRTYEESFGTTSGGFTITYEEHSATYQELTIKSRRGAILISKDPIHKNYVPMTFVCAKRPEPSDLYIVIRDDHGSYTRTPYLLRPIEATKQYAPTQVQLFVETTDPYMQGCGVAYESDDLFKPETPLIYDSIGQDVGCKIDLPSAKEAAFYCPAPYVLDPPNCFYQVYVHGEEKDLSEISNSLVASHSNHFVTLKFKSKLVELGGKRRKTPPLECRCVTVKGVVLSTIQIENYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3J8</accession>
    <name>A0A061D3J8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767344.1">
        <property type="nucleotide sequence ID" value="XM_012911890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3J8"/>
    <dbReference type="GeneID" id="24563699"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203150"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="402" mass="43447" checksum="24140898DD848576" modified="2014-09-03" version="1">MVYESLIDVPHNVKEGIDWLVALKGDDGDEHLAALGEAIHKYLSYNFKNNPELAKKLPSLEHVKLISMGFMWNKELRGLWPAKDVLGNFVKAMDKKPSYFVNAMGSNPAKITKNLTKFFGGCEKFLDEIKHPATYESAYSSKATWDASCSEIPEACAAVFVGIAPMLYLGLESMRDASASQSSCWWPFGKKKAKVNFGEVVRAVGYDDLDCLGGAGSASALKAVKNLNPNVVDIVHDLCGFDAVYESENPESVPAEKSAEPVADGSSVEGEGEQSVIPEAEPTFEGEGEQSVIPEAEPSVDGEGEQSVIPEAEPTFEGEGEQSVIPEAEPSVEPAGEEPVIPEAEPSVEPVKPEVDDIEKPVKVAKAAKVARSVKAAKKAAKKVSRKARQKKEKKQQESAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3W5</accession>
    <name>A0A061D3W5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0110450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766933.1">
        <property type="nucleotide sequence ID" value="XM_012911479.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061D3W5"/>
    <dbReference type="GeneID" id="24563288"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110450"/>
    <dbReference type="OMA" id="PYAITIQ"/>
    <dbReference type="OrthoDB" id="360151at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14886">
        <property type="entry name" value="MYSc_Myo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF270">
        <property type="entry name" value="MYOSIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="91"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="8">
        <location>
            <begin position="1201"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="8">
        <location>
            <begin position="1312"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR94747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1469" mass="163910" checksum="8444562B7CFF777A" modified="2014-09-03" version="1">MAGPASASAAGKAKPGGKGGGDHFLRMESRVENMDYLIGQHVWIKVDSDELFALVTVKSYSADKVSVSYNGEQLTVPFEHCLNVDVMNAPLETHDLVKLPHANSAVVLDILRTRFMSNLIYTYAGKLLIVLNPFRLIPDLYGPNVIERYRKSDSAMGFPSDVPPHTYAVAQCAISGLLRNGQCQSCIVSGESGAGKTETAKQLMSFFAYGPSKSSDNVQQVVMGSNVILEAFGNAKTLRNNNSSRFGKFIKILVAPEGGLKGGIICSYMLELSRIEFQAEDERNYHIFYQCLKGLTVEEKQSYGFRPMESYRFLNGGKCCDAPGIDDVKEFAAVRRELQTLCPDSGFADFMRCIAGILLCGNIEFTEVAAMGVENAASVSNRDDFEQLCGLLGFGSEQAERALTTKVVKIQGNDIASAITVPAAEVNVRALAKDLYGALFEFCIDKINSIIQFDDSAQRWIGILDIYGFEYFQRNTYEQLLINYANERLQQYFINRVFASEIAEYDAEGINHSSISYTDNSEVLLVFDKPNCSIFSFLEEQCLIQTGSAERFTASCKSKIKSELFVPAQGAVCRFTVIHTATGVTYETDEFVAKNKHKLSPAILELLHNSSNSIVRESSARIPAETGNMKGKFLGSKFQSSIGALMRTLNETESHFIRCIKTNQQKQPLLFETRNVYGQLISLSIVEAIQTIHRGFAYRATFEKFIQDNEFLNSFLNFQSSGGSDMKSSIVTIMRNLGIDENEYQVGHTKVFLKKNGWMMLEKVFLQYSQASKPLTAALYSIMRVWRNRRHLERSRSAIIRIQSNMRRYVIQASSIAMRERANEFVGLVLALDFMLNEDPRVGAATTIQAWCRMFICRRRYLRQLEAKRAEQRRLRATANLRRVKTVVRVVGVCRFMVLACDERRFVRAATTIASFWRMHVAIRRLNNLRLRRLTEFAATMIQKHVRGYLCRKGYRHLLGLRVPATRIQSLFRMCLAINHLPRDVGLRCRQIRERLRAIQRLAVVQTLARSVVFHRQLLAAHDAVLSLQKFCWPRACNKDITRVQRAGATIKDHWRRYNQSSVVRVERNRLLDGASRQLLERLTTEETECAHRVLQRSAASRNRRLLPVHVNVYSDHRPAYPSGWSTCLEQLLCKGGSKPPGMTSVGMCLRHSVAVLDDREVYAFGGGSRLPRLLATVPPPLQVTSVKCGAEHAVLLLSDGTLYGWGGNANGQCGVAPSTAAIKSPTLIRMPFRDGQPIHVRSVGVGAYHNCAVGVNGEVLVWGSHVDLNLPSFNEDILTPAEVPAGEWLRGERAEEAHCGRRVSYLLTAGGQVLSFGRSTNGQLGHEFPERRSPRPVDLPDRVVSLSCGGNFTLAVTSKYEVFVFGTALCVRGGRELQHTFALPTPLAVDRAVLRSPVVRCSAGLWESNVLTEAGRLCAWSHLRLDDGRARPIIYVYSCASECALLDVQSAYCGSLSATLAVMQRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3W6</accession>
    <name>A0A061D3W6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0205690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767597.1">
        <property type="nucleotide sequence ID" value="XM_012912143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3W6"/>
    <dbReference type="GeneID" id="24563952"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205690"/>
    <dbReference type="OMA" id="KWIKTWS"/>
    <dbReference type="OrthoDB" id="364314at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="807" mass="91190" checksum="B52273167C7392C8" modified="2014-09-03" version="1">MDWRSIGTSFVPSLEEKPSRTSAQPLPLLEDNGNDKPPTYSRWQYVVGVASEDQSVLLQKLEESKEGSVRGGNRHAQPLAILDTTTPKARYYENQVCWSDENGVIKERIKSFKELTLDPTVAPSLDAWLRYIRAKAGELVLKLQGNKTNVPECMLTRLNIAQELEVAAQNCELLHKMSGIVKLTGNVEWCGVQDTAGIAYMFILILFYKKMLIPTFDDVLDTVKWIKTWSNDYLRVDQLRHELTTHTHQLVSTEPVYWEYMSGIVIQTPMEHGRFLKVTSVFFNHLSRMADMDIAPRGKIEKSIVVLLTECFIPRLLASGHHDVAVNVIRHWLAHNMLGSNSCDVFANISKHYLLHSLSIVQRQCNLDKSALMDLCDAVDAFLKETGQSQQVELGYLKSLDYCQVDPVDVVQLPIKPFKLCNDHANELLFRILELFGSESVDRVPSNSRWYNFVKSTVVNTRCAKTFRTLLLMHAMVVTPEVKIFWCLLMRACQRKDISKKILQLNMKDPDLWATYAAITTTVSEAKVVYEEAVGVFPNHFPLLVAWLMFCLEHDRENADGALTSLKRELDSRCGTQTSAPEHESAQSNALGAISPSRACATVLVWMLGNRGRLHEKRCIAEFKSMVFVLSEYDVGVVLRAACLCMPPKIAQQLAEPIVRTYPNNETITALYVEHCIARVDKPAILRLVSDYLVRPLISMATKHMAQFADCLRNKNYDGGIRLMLLCRVDLSGNVLRSIIEEPMPFKLPSVRILLHALKSTARTCDTVQLVAKHCAFSKALWLILAEHLPASSNIIEEDMKANGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D3Y5</accession>
    <name>A0A061D3Y5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0100180</name>
        <name evidence="3" type="ORF">BBBOND_0313790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="0" first="0" last="0">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid AJ."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva Nishadi"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012765875.1">
        <property type="nucleotide sequence ID" value="XM_012910421.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769663.1">
        <property type="nucleotide sequence ID" value="XM_012914209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D3Y5"/>
    <dbReference type="GeneID" id="24562230"/>
    <dbReference type="GeneID" id="24566018"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0100180"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0100180"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313790"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="59" mass="6470" checksum="67BB6B878168D154" modified="2014-09-03" version="1">MTNTGRAIIRIAPDTAMPAAYPGSSSSPILFKNYSTTPPLHSNEIRTSNLEHLRPTDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4F7</accession>
    <name>A0A061D4F7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0206210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767649.1">
        <property type="nucleotide sequence ID" value="XM_012912195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4F7"/>
    <dbReference type="GeneID" id="24564004"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0206210"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0206210"/>
    <dbReference type="OrthoDB" id="366342at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595960" evidence="2">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="340" mass="38820" checksum="7E2B6F79F4A0DCEE" modified="2014-09-03" version="1">MIVTIAFALLPFMQIEPIVAAETSEQLNLSNEGIANRTMIVEEPDYYGIFPTASRRFKVLMSLMVEDGFRPELLEFASEKMKDVIKERMDSWEAEILADKERQDGDLKGTKVVSGRIPPPEVLRQNLEMKEQLLDSIYYKMDECREALKEAGKSISKIFENLFKDYARPGISQPQQNVASREPQVNTESSTNNVNTAVQGTNSPAEYVVKQYKNENDYINLRFVMPSFSEDLLSLHKAIQNIEIEKQQDSATLKDVIMSWAQSHLPKMELKDEIDGITIKKELEMLYDTYFMYYIVTSFREHNILDTNVNAAVVKCKNMNAASFGTMGLLLAAVIAFTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Q6</accession>
    <name>A0A061D4Q6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0208450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767877.1">
        <property type="nucleotide sequence ID" value="XM_012912423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Q6"/>
    <dbReference type="STRING" id="5866.A0A061D4Q6"/>
    <dbReference type="GeneID" id="24564232"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208450"/>
    <dbReference type="OMA" id="WITDIQA"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="88" mass="9871" checksum="9F42F8E9ECED13A6" modified="2014-09-03" version="1">MSWITDIQASLQSGVVDFYGQNLSWHVLNVLLVIGTVTGVIVGQVKQDFDITMRIVIGTSLLCAVVCTPAWPMYNRHQIPWKPVKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4S8</accession>
    <name>A0A061D4S8_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0202090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767238.1">
        <property type="nucleotide sequence ID" value="XM_012911784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4S8"/>
    <dbReference type="STRING" id="5866.A0A061D4S8"/>
    <dbReference type="GeneID" id="24563593"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0202090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0202090"/>
    <dbReference type="OMA" id="AKPEMKG"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="9">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR95052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="104" mass="12159" checksum="2312A71EE7BE2F57" modified="2014-09-03" version="1">MAYPYRPKFLFKYPDYIPPTDEQDAQTDPRLKLEPACLEKCKSFRKLYDECAERVKHRNAIYKEAAEQGRGLEVQGPGQCLGQHYDVVHCVDNCVAKDLFRYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4T5</accession>
    <name>A0A061D4T5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin dependent kinase binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0102870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766150.1">
        <property type="nucleotide sequence ID" value="XM_012910696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4T5"/>
    <dbReference type="STRING" id="5866.A0A061D4T5"/>
    <dbReference type="GeneID" id="24562505"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102870"/>
    <dbReference type="OMA" id="PWLHPTL"/>
    <dbReference type="OrthoDB" id="5353095at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF0">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="266"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR93964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="391" mass="45533" checksum="51FB19D9EC0FD795" modified="2014-09-03" version="1">MRRQSNHIDDYSLTEFQELLTDLRFTSLKTANLSTNVAVAFLTGIPHVSRRTCDSSLSRMPTYNDSYVPGTPYESYPLDQDRIIELEEERIERQYTVDGDEGRSFRRSNSDGHQQEEELGVSKTRMRLMRWQSHIANMWRRYRDRRSDILAAPDNHHMGLENRETQRRKKFYISYAELIIPSQDTYNPNFMNIPLHYGIVKARACGNASPGNSDVFDAPEVLSVEISDFAEINSRFRLDNEWLHPTLSLTKLSRIKLTMFLAPRFVHHLDPSTVFSAWILFERLVIKGVVTKQNRRLYAATCLVIAYKFNQDGEHTAVNDVIAYLCRDRSITPTAIFASEMKVFTQLEFSLKQSYSGMRRHVQHYLELNHITFMDLYETSESTYLSLEGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4V7</accession>
    <name>A0A061D4V7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Charged multivesicular body protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0208850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767917.1">
        <property type="nucleotide sequence ID" value="XM_012912463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4V7"/>
    <dbReference type="STRING" id="5866.A0A061D4V7"/>
    <dbReference type="GeneID" id="24564272"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0208850"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0208850"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="191" mass="21403" checksum="B0F9ABF129E73864" modified="2014-09-03" version="1">MGNKQSLMTTSFNLRLQAREVLKLHAQCEREEESEKLKVKFALEKGNIDAARIHAANSIRKHNEALRYLQYHAKLEILRHQVETAERSNSVSTELRKALPQLTKLTSNKSMDSATLFTEFEKVFDDLEVKEAYTEQTISSSTAHLAPQHDVDTLISQVADEHALDVGGILDSSSAIRGAVVSRSDADRITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4X8</accession>
    <name>A0A061D4X8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ser/Thr protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0103320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766200.1">
        <property type="nucleotide sequence ID" value="XM_012910746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4X8"/>
    <dbReference type="STRING" id="5866.A0A061D4X8"/>
    <dbReference type="GeneID" id="24562555"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103320"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103320"/>
    <dbReference type="OMA" id="MEYCGEE"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13996">
        <property type="entry name" value="STKc_EIF2AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF178">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="243"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR94014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1135" mass="127656" checksum="E14B23E60AAB74F0" modified="2014-09-03" version="1">MLREASTSVSQQIRNDIECLIKLEGVSLYIVDRGFLSQGPEEEESEQSSIVFEASSGGNEAATACQLQVVITLSGCIHSVKRNRDTVITLGVEVPVEFPQGDIRVELIQISNAQKTFERTCINRLQAPSLEERSDSSEALGLRDRILSFYRYLQETVKQATVGSKREGNDGSLTPGEGNTSSHYCSDSSLSDESREILSSVTPSESVSLLSGRRHLDVYTGTRIESARLHKLLAMHSRYYREFDHQKVLGSGSFGCVTKVSRNGIAYALKQIPIYKNHGRTLHEEAAVLASLQHRYIVRYYDAWVEEPYDVIMSKFVGPEPRQGSHSLQFSYAGKNVHSPLFDSGSISLMGGFRVHSSLQRKIRLQNQVSREVNSHRNSKVRHVSSSRRKSKPVKYLFILMEYCAEDTLLNAVSDGRLLGKPQLAVELLRQILEALSYIHEKRIIHRDVKPSNIFLKSEDETLSIKLGDFGLTAKMRTDPSSMSTGVNPTGVVGTIHYMSPEQERGCPYDEKVDIFAAGVVFFEMLSPPFSTTMERSEVLSSFSTTEKKWPSEFQSRVETRVFKVLESMLSVDPTKRPSASQLLQSELFACFKLDTWTLYQVVSQYPHSMESTQLLASMFGRNETADSTFSYFNRLPDDSASSSYVNVELLRRYSQELGRRGAIRFEAPLFVVASADEDDPQSELEYHLLLNDGRTCQLRTCILSALAEYIPPVFLIVMRRWYWGKAYTRDPAGGHHPCESWRCAYNIIADYSILLQEIGSCSDALDTFFTAELIYTAVRPLIRFVPSSVTVEWTYEHFACRILEEGVGLHGRWLEGVRHLIVENAKRTNVMKQRLAEYLRAVSVPGFTSESLCSCVSQIAALLSTGVVSPVGDYMNSIARTLHSFGREVMQFNALARHLQSMERYLTLKDCEFVFVPLGFAPWHESKYTNFSFNVKYTVGKRVFDGLVGGGCINSLLPQRKGTIFGPPQRNAFGFEVILDPLISHFLQQEASILGKSGMVGLQCGYQLFPQVLICISIQDVVHRAVSLEHGMYKAGIVVEKQLGYPSSVRKLRKHISGGLLPLSRLEVLVIVKHWTGSSASGAATTETGKFEATYPPTDVQYKLIFVHTGNEMILWDEREVLNQVCQHVYRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D4Z7</accession>
    <name>A0A061D4Z7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/hydrogen exchanger 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0103480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766220.1">
        <property type="nucleotide sequence ID" value="XM_012910766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D4Z7"/>
    <dbReference type="STRING" id="5866.A0A061D4Z7"/>
    <dbReference type="GeneID" id="24562575"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0103480"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0103480"/>
    <dbReference type="OMA" id="GFEFEWF"/>
    <dbReference type="OrthoDB" id="441412at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF86">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595803" evidence="12">
        <location>
            <begin position="31"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="184"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="706"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1162" mass="129085" checksum="61BF96D86F3D60C7" modified="2014-09-03" version="1">MERPAPWRWRAVPLLIVLVASSQLWHAAVCQQPIKKNPSKSDAPHNPIPFTHPPEAGEKGVETSSTGKAWSHVQQAAASTPLSGTPYSKTDHTVAQDNAGSPRSLRAASAATNRTTPESPLSSATFSSAPQNPSSMIKSESASIPSGEIPGETDSHDPVNGNPAAVSPNVAQFVTLTSFIFLSACVLQFIISKVNNRIPISIACFIFGMITYGFTVLLEPYGRSDPLSLSINGLRHIDSSILYYAVLPILLYEATQEINWYAFCSFFLGGVSLAIIGVVLQVCLLGTIFHYVLNIAPNQSVTISFLLASILSSTDPVAVLAVLSGVKAHPKLSSIFNGESLINDGSSMLLFQFFYLLLVGQPRPFWYHGLVFCQLLLLSPLLGVLVGVVVAMWISHFRKHHSAQCIAVITCGHLLFFLSEYTMNLSGPLSLVCYGIFIKVYGVMAFDREALEKHHHLVEGLCLMANSAVFLISGALTVGMLRSQFSRPNVMLLLWKLFGMYLLLNLARALMIVVFSPLLSYIGYGVNWKETILVILGGLRGALVLVLGLRLESDTHTPQEVSDLLAFYLGGNVMLILLIQGLTFELVYRWLSPYPMKPFRRVYLVKVMNLIDYEFNLEVDWLRNHWLFKNTDAVERARTLVPLMSTIRWNATGNLEFDVPDIDKPFDDYIQPDPIELHVYQENMQFEAMTTLHSCKSVRSRSSAVSGAGEKADVAQPASAPGSGDAPGDKAPDNSCDCLKCPEEPPTPAESRSDEPEGPVSTDRPLLAYSILKNKVSSDNAAYDPKRYLRLLEHAMTDDMGEAPEMHRLSSDLLSVPRPSMNPPGMPAYGSQEGISPYAWAQRSDTDATINLDNLYQRPVHKRFITSTLVPRLNSDDRIFENCEHESADGNMPGTRRVLRKEREGELYIMIFNAFSDMYNRLYESALIDGGSLLLLQNALDRARDFALKKMKKRAIAAWEAVLASEPGPDSGRPEPPEGVESMNGFEFEWFILHSMVDKRMSRMDSCLGWHVLNFSQHNVVQSVLELLVAYIDVHQHLLDRGGRNMELLLEGKLINSYRSQLGHAKLYIATLRSRFPQDFSHGLVTMAACMMLRIKLDVVNEQSTQGLLLEEDRSRVVEVLEEQLFNVATTNNRINVFKRLFKRAFQAVTCRRGRGCNGTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D562</accession>
    <name>A0A061D562_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0203440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767373.1">
        <property type="nucleotide sequence ID" value="XM_012911919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D562"/>
    <dbReference type="STRING" id="5866.A0A061D562"/>
    <dbReference type="GeneID" id="24563728"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0203440"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0203440"/>
    <dbReference type="OMA" id="NDFFDRG"/>
    <dbReference type="OrthoDB" id="365892at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="896" mass="96047" checksum="B214D0A467DD9E01" modified="2014-09-03" version="1">MYSAQRFVPLRDAGLEQASVRRYNVDFCQVYANPDSVVHDGSGSLKLYVVARRNSTPSLQAYMPYDVFTHVNDWVDLQEACSVADEDIFDNGISSSDEEGSMYIGGASPPLIASPEPFTSPGRASSAASRSHPHHFDSDASTVRSATRSAARSPSQPSARRPVYDAVVPAAELPQDEGIADEIVEDDDGPIYHGVSPPPVLSRSPAPRSVSFAKPVVVASPRPRGKRTISGRNNLSPPSPTGYSPFASFGAVYSSGLQGQTAQDIAAVATDTLAALRDLNPVAPRATAPNVDPAPAPKRKTKRGTRSKRAPAAEAPETVSMASAGADGMGLRIVDASVVDPYPIDDTFDEPYYPTYHATDDLGEDTGTGDLVATSELSGHADPPPAAASDAGAKNRKRSRKRVSTAVLSLPPTTVEELPAAAGTQRHPDEPRAIADTAAPAAAPSLRHDQGVQTLAVEPMRTSLGVGNDDFDMDEYNSLADRVTAGSLGPKIAKKPAPTRERRPRKAVNSAMLLNSWYISYVDDRKGTKKRYEPVDPYVGRNRRYPSRARLPPIQHWNSNITPDGSSVLFLIGVTSDDTKLNLQAQHASGDVVLFNEDAAAPESSPSARVHPDNLPEASLVMTDSSGMMEMQVIESSPMARLALSDRAHNVPTATSTELALADVGAPAVEPGAKRRRSRRAAKVPASDGDIGVDAGTAPRSAPAKGKAKRAAPKPKPGGRKRTRQMTVSEALEILKSDSAGSSLGLDESPKSRRQSEFYQELAFNHPKKANVAALPSDSIAMQDGRHISYRSFFRVDEVETQMYHGSLFQPLVMNSRCRSSNVIIPVGCHVSMGNVNGNFICGYLYCGENVAIRGLGISWPLKAKQTFFLPIYEEWGIYNESRSMDANIALTFVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5A9</accession>
    <name>A0A061D5A9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768062.1">
        <property type="nucleotide sequence ID" value="XM_012912608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5A9"/>
    <dbReference type="GeneID" id="24564417"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210290"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210290"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="298" mass="32916" checksum="80C1E0E2A22746C5" modified="2014-09-03" version="1">MAQTQVKGNTCQCFNITCDKSSNGPCSDDKCTTCKTCCDPDCTRCKDKCKENDSCRCHIPRCGCPTNCYGDNGDGTCKGKDNNSCNRCLTKCEKGQPCKCYRCSCGTKCNGVICSCCKWCDPRNCSGKKCDGYVIGRCGDKIPKPDKCQGHVKYDNYDDKYGAVLKRETKNVITCDGRPHPGKVCTENNCNWLGGVLQPDGNCVKLCTYCGDLCGQDKFRRCCYIAIPVVIIVLAFLIFRFMLPEKFHAITTKIRAAFPSSPRHPGRSLSNLVGDRLPEEMSVDRYPAFRPKAFAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5F5</accession>
    <name>A0A061D5F5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteoglycan 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0210940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768132.1">
        <property type="nucleotide sequence ID" value="XM_012912678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5F5"/>
    <dbReference type="STRING" id="5866.A0A061D5F5"/>
    <dbReference type="GeneID" id="24564487"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210940"/>
    <dbReference type="OrthoDB" id="10659792at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02389">
        <property type="entry name" value="Cornifin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005405853" evidence="2">
        <location>
            <begin position="30"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR95946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="747" mass="78820" checksum="99F2A1FB9FAB0EA7" modified="2014-09-03" version="1">MGLGVGFGAAVRRVLLVCTVALLANNALATVEEAPAVGKADPGRYAAVSETPERQVSNTPSPPESPGTPGAPSQALKDTPDASKEAAYGSIVKTAPEKASTAEVTPEKPSEEVVQQGATPSTEDPVELDFENATLVPKVLPDSGREYAEVVGKDSSKTPVEEVKTPTKEAPADAPVVVGTVMKKAAPPPAAGKVPVKESLIVPSRAQFTGEDTGAAQSGGDGKGVKRGIEALQSEDPNMPSKVSKTITSAAKPDAFDKVNVGADKTAFVKDDASTNGTTTSEDASSASRLTTLSGDVMVMEPIMESELEWEDEFEEDDDDDDDESSWRPIVWTTPPPFVDMAQPYVLPAAEQKSANNESAKVSTPQSPTVKAPDATIVTAPDATTVKAPDAATVKAPDATIVTAPDATTVKAPDATTVKAPDATTVKAPDATTVKAPESTIVTAAEPRRYEDASTQTDPVIVLEPLEITNEPNKSIGAESSSVAGSSAPAKPLRAQIGQYTTRESDGNKSTVTFVNRYGKPIGAAYKVQSVASSSSEVPMGTIRYRQSPDDHTYSNIGGAYMPLGVTAALQPREYGTSYGDYVPMSAGPTQFDDPEKHTYEPLHFLEENDEEVLENQDETAANDDDDDEDIYEAINLNRSTEEPKSEPTTSQNLSGSQKRTSVTDAYVASVDKAAARLKKPFARFKDYAAKKVNAAKSYLFGTGKKVTRAVDVVVDCAESGCDHARRAKDDIAGRLRRGHHAESDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D5R5</accession>
    <name>A0A061D5R5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0210460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768079.1">
        <property type="nucleotide sequence ID" value="XM_012912625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D5R5"/>
    <dbReference type="GeneID" id="24564434"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210460"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210460"/>
    <dbReference type="OMA" id="PFECECC"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="154" mass="16992" checksum="00A433CF0A5C323B" modified="2014-09-03" version="1">MAKKRAADASSTSKKVAKSNAKSTGEYKNEKKKLNDVFKSLKGQPTTTVPDRTTLKAPKNDAKESSSSSSRSRKSEVYAQVPVSGTARRRTEDNLPVYTIEELNIGKLKPEYNKCSLMILIQSQGREEALICARLIARAATDAVCLWTTPYTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D622</accession>
    <name>A0A061D622_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768194.1">
        <property type="nucleotide sequence ID" value="XM_012912740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D622"/>
    <dbReference type="GeneID" id="24564549"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211520"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211520"/>
    <dbReference type="OrthoDB" id="361744at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="407" mass="44984" checksum="DAC5D72022959C64" modified="2014-09-03" version="1">MSKSLASFLDRRKKSTVKAATLLLQTEEAAKEKQKAKDGLDEPQPEQQSDHDDEWKVSDDEETKAIQKQATFSGSLLMSVRTVTGDGSEERGPRNDAKPTQHVWQSIVEPPVKEEPQPEKGGKVWIPKYKSVSYVGKDDIDLAEAARLAAAKSEQPSGSKVKKVKKKPATLQPQDDDEPARYVKVKFNVFSVVDEEYRTFNAPLPTSSVDSEKVKAKYIARAAFACSMGATLSDEERLAIDLQVRPPHELEQPLLQVHSALLCALCWCERAPTWTECIFSVNRGPISMSEHFFSLRKTYLRALAAPPRLLPVVSEEDHVTLVVPGDDPPCLELRVLRAVSGGGRRPTSGNSDAICRPILRPSRVLKLLRMISDLLSVKLPEPFMSLASTRLVSRKNVVGPPASGQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6A5</accession>
    <name>A0A061D6A5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0207050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767733.1">
        <property type="nucleotide sequence ID" value="XM_012912279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6A5"/>
    <dbReference type="GeneID" id="24564088"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207050"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR95547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="67" mass="7577" checksum="BAB31535D4D9F8CE" modified="2014-09-03" version="1">MAELIVDMVITDKNLVTAVQPCTISALSQKATYHGRHYKAINASIATEEVEKITQHNFAKMEKFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6D5</accession>
    <name>A0A061D6D5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0107920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766680.1">
        <property type="nucleotide sequence ID" value="XM_012911226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6D5"/>
    <dbReference type="GeneID" id="24563035"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0107920"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0107920"/>
    <dbReference type="OrthoDB" id="10564114at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595501" evidence="1">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR94494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="129" mass="14388" checksum="943FE1A0A0EFF928" modified="2014-09-03" version="1">MAAFYRILFLFLLSFFLHEQVNAGTMTLEKARKHFSGTSAFRGSDYDSRMGHNAHEGKTFNALYNKYAGSILDYDQQLAGFTQSGSGPYEDDRPIKLSKHDFMCQSLFAAGLPVGADCRTRGPGRYVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D6I6</accession>
    <name>A0A061D6I6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768354.1">
        <property type="nucleotide sequence ID" value="XM_012912900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D6I6"/>
    <dbReference type="GeneID" id="24564709"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300730"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300730"/>
    <dbReference type="OMA" id="FNSCCMN"/>
    <dbReference type="OrthoDB" id="390934at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="616" mass="67335" checksum="583EB0F1FA2BCEEA" modified="2014-09-03" version="1">MSTHSSQVAQLSEQQGTSRPCNGGVSVPLMKSCCVPGDGTVPITIPVYSPFYQGTQLLSGSAGIIPQQQYVFASPTGMNKVVCHGQAVPQQQPLYQIQTDVFTNQQQQNVNADEPINVTHYIWKQTEEQTRPIKHQGTFAKLRTLFNWQDSNSVFGDETQNEQAAKVSDELGSQQGGDNEQVQKIKKQQPSGFFNSCCMNVAQLPTFENCASSVCNINRYCKLNTVQGEEECVDEKANTTRENSITSVNSLTGKQAETIVSQQSSESQHTVVAQENTNLQNAFQQCANRSVPESFQQASIHSQHGMIPQSSICSNHDLVNHVVVSPLNALSQQPSIQVGGSNASSIPSVRRASFVDNTQTPFCFNMCYPRTVSNQFESVVPVNSFQNPPSIPVNNAAVGCFGMCCGGAANNFTTLASQGTMGLRNLFTMNPVSQRSIISNQSVPVEQLSRQMSAMSVNPTQEVVSDIAQEQILINDTVVVDRNGRNVRKSAMKPKTFKLHAIEIHQFVPIQNNAVSPFVETLSGMNQAGTPIFHHGYGIQHPNSFFNPNTTGHIAPVIKDVMQGVTNPKIPHMYSVDSSHSCQAVRLPTEESQVTPREEVNEAPVEQEQAGESQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D704</accession>
    <name>A0A061D704_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0303950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768677.1">
        <property type="nucleotide sequence ID" value="XM_012913223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D704"/>
    <dbReference type="STRING" id="5866.A0A061D704"/>
    <dbReference type="GeneID" id="24565032"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303950"/>
    <dbReference type="OMA" id="GMSLEMQ"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000054">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="73" mass="8696" checksum="D3CE5789D4739840" modified="2014-09-03" version="1">MIEVILNDRLGRKIRVKCNSDDTILDLKKLVAAQTGTRYDKIRIQKWYTIYKDHITLEDYEIKDGMGLELFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D712</accession>
    <name>A0A061D712_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PROTEIN ARGININE N-METHYLTRANSFERASE, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0304050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768687.1">
        <property type="nucleotide sequence ID" value="XM_012913233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D712"/>
    <dbReference type="STRING" id="5866.A0A061D712"/>
    <dbReference type="GeneID" id="24565042"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304050"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304050"/>
    <dbReference type="OMA" id="FDCIFEP"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="189"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR96501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="537" mass="60117" checksum="7E952289662C9C8A" modified="2014-09-03" version="1">MSSSDSSDSCSSGSELEETWEGEGVATSLFDDFSSPFASQVYRHMESKFGFDHRILGKGTLHRVALVTYLEREKAKGADVLDCYQRIRSDPSIVLNRMEEFIKPPFENEKLLWDFMESSDEEGDEDLLSKHLSQEKGTKTAQAIRKRASEDESYFKCYKGLGIHREMVQDAVRTGAYEAFIRLNKALFKDKVVLDVGCGSGILSLLAAKHGAKLVVGIDNCENLVNMSEDHARINNLTNVRFLHGKVEDSDLAYVDGVLLFKRDANSDTPHEPFKCDILISEWMGYGLLYENMLPSVLFARDKYLTEDGIMVPSKVKLGFFAIDMHEELSAKMREWNEPKYGIVLSGLRYEAAELLKVPAVEAADPSSIVSDASGICVMDLKRVKPSELSTAHDFEVKVHDGKTCSSLVLYFDCIFEPRNTADGSFPAVLNLKSKTFGGLESYRESLPGVDTTRTYSVSPDYAGSEEEGGVVVVMSTRPDQTTTHWKQVLLHLVDHNDAPVRLNVSLLKNPTNNRWLDILLRLRDSAALGDCYYKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D763</accession>
    <name>A0A061D763_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0209500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767983.1">
        <property type="nucleotide sequence ID" value="XM_012912529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D763"/>
    <dbReference type="GeneID" id="24564338"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0209500"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0209500"/>
    <dbReference type="OMA" id="FHINYGS"/>
    <dbReference type="OrthoDB" id="365855at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30789" checksum="430410CC0B274C03" modified="2014-09-03" version="1">MIPYRAANEFGGWRPGAEPPDTDSEAELEAFYRECMSAASGDAAAASSKKRYEYVVFGIFRDPSVHVPETAEPEPEAAQANPPSRMSDPIYQSPLCQEFLDTLSHLMETQRVEARHLLAYRRDGERHARASLNFTSKEATVKSSSVKVNVHKPPSPLAGQCTMVEANEKPVVSSADVVVRPIGGAVNADILTVLPLCGYRVVSRMFICGHVFTSNYGNPSQVEVAVLRHYADCNPNTPVSPDSLLVEVRCVGDGDPETYKARLREYTQLLYKYVDFSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7G7</accession>
    <name>A0A061D7G7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0305540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768837.1">
        <property type="nucleotide sequence ID" value="XM_012913383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7G7"/>
    <dbReference type="STRING" id="5866.A0A061D7G7"/>
    <dbReference type="GeneID" id="24565192"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305540"/>
    <dbReference type="OMA" id="MNGYPFF"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR96651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="114" mass="12995" checksum="98D1862EC2713686" modified="2014-09-03" version="1">MFATAFFRLARPQPFLVQSRSVVQSRFAKKANDVAEKLPFKVTRTPSGNLAVYVKIRAHGTLVYTVVRRIYGDVDAMKQQLRILCESPVRERIGSLEVHGLHVKKIKKWLVQCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7H6</accession>
    <name>A0A061D7H6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UFM1-protein ligase 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0304020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768684.1">
        <property type="nucleotide sequence ID" value="XM_012913230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7H6"/>
    <dbReference type="STRING" id="5866.A0A061D7H6"/>
    <dbReference type="GeneID" id="24565039"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0304020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0304020"/>
    <dbReference type="OMA" id="PQCYINS"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25870">
        <property type="entry name" value="WHD_UFL1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="660" mass="72558" checksum="2D2705574715677D" modified="2014-09-03" version="1">MPSIAELRSRLARAQTKVAAARLSSSQCIDLVLKVCQKRNITLIPTLDGEELLTLQQLELDLVAAIESRGGRAAVSELAAVVGVQQNYVDRTVEKLLKEHPNRYMRLQDTLITTAYTDWLTDTASRRLQECGVLNVCDFASEFELPFDLIKLLITNSKVIKGRLNGTLLESRGYEACKERCILSALAATTVPTATMHLAKVTRIDINLVNDVVGRLVNEGKVSGTFKGGVYTPKVYTDHRHELLAAFYSANGYIERSKIAGSGKSNKDNSYKMFPDALLLDTVLINRNVLEPVSVLVNEAIATAGWRDISIMLPASLTPTDYVALLEQIKGASKNGYVVAGLYVSLAFEESLVKHIVEALKDRMGAKKLLDTASDAVETLIDEASALMDDDSTSAFAECWAIASTELYERIEPSMVALIRKVCVVDRPTHGHSGFDVEAATEKLKEHHLKFDCTLKVMEKLGGGTVDGAHLIMKTLAKELLPVDCHLLLQVYATQNFVEIPGEGGEINAGNRAAVVEAIKDKEVKADFSAYFEAIKQKDALKGIEASRSLKAAMYIACNVKKERKRFLKVQSTHYEQLLASLGCDDALKAAYCALMLGLLRNGHYVFLVDKDWCLRGCVESLAEFVGKADVIEAVQRCVEGKGELFMCLNPIMNVQTRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7R2</accession>
    <name>A0A061D7R2_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768912.1">
        <property type="nucleotide sequence ID" value="XM_012913458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7R2"/>
    <dbReference type="GeneID" id="24565267"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306300"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306300"/>
    <dbReference type="OMA" id="SAYIIMD"/>
    <dbReference type="OrthoDB" id="361180at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596059" description="OTU domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="75"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="306" mass="34460" checksum="DA1EAEA3D6D28A76" modified="2014-09-03" version="1">MKRVFFALMCALTAQLCLAAGNGSTGSLRSDALIHTHGQAGARGWSAVHPCDRYSSWKRTTSRWDSFLRRNGMALCRKNYGADGNCLYNAIAGILKDYELTIQRVGITVKTLPAGISISLEDLHFSGEYYTVADLRRICAISFIGVDPNNLNALPFWEKDIFITKLEILSQVEGSSDYGDMRWGPSKFYQEILAGGDRVDIAKRVYNMLSQVRNPYTWGSYEDIDALAHVLNLDIMLFWNTDTKIQLFRGHRQPRERRSALLLYYTEMVHFDGAGLVSDITVSPPVPIRSMYSANTFPDFLRALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7W0</accession>
    <name>A0A061D7W0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP RIBOSYLATION FACTOR-RELATED, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0305360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768819.1">
        <property type="nucleotide sequence ID" value="XM_012913365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7W0"/>
    <dbReference type="STRING" id="5866.A0A061D7W0"/>
    <dbReference type="GeneID" id="24565174"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305360"/>
    <dbReference type="OMA" id="HVRIYAC"/>
    <dbReference type="OrthoDB" id="442317at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="205" mass="23023" checksum="B1DB111E66176CC7" modified="2014-09-03" version="1">MGGSLSCRRPLSVSPQSYPTLQLHVFGLAGSGKHSIVRFLKYGVPVLDAKRDDVEVDMQWITHRKVRMLLWVSEHTAQKEVANATDVARALVCVVDGSDPDKLAAARDYLFTQLQETTGTPNLLILLNKCDKHSFVFLEEAHDALNLDQIRDRHVRIYACSAATGEGIREALDWLCSKFHLQNGIYVSRKGEQNSYQPHIFADTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7W1</accession>
    <name>A0A061D7W1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0201610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767190.1">
        <property type="nucleotide sequence ID" value="XM_012911736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7W1"/>
    <dbReference type="GeneID" id="24563545"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0201610"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0201610"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="96" mass="10975" checksum="02D8325C8DBE0286" modified="2014-09-03" version="1">MYLTLGHAAYDDGHYRAYRNNQLRPSGVREIRRRNNGDGGVSQMGSFEPSAKFQCANPSDVEHEARQLWLSERHSPPDRVDAITDGTTNRRHHRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7W2</accession>
    <name>A0A061D7W2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0306750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768957.1">
        <property type="nucleotide sequence ID" value="XM_012913503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7W2"/>
    <dbReference type="GeneID" id="24565312"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306750"/>
    <dbReference type="OMA" id="IKFPYND"/>
    <dbReference type="OrthoDB" id="360649at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="217" mass="24637" checksum="17CD9AA6268E16F2" modified="2014-09-03" version="1">MSAFRSEAHRAMFLRMIALQLRCNILRRFGGVRQEECRVLRSSSARRLLMHWASDIVDRLPSDSVSQPSFVARESASVPARVLRHPAVEPLLREDAGLRWLVSRLESDDALVPKPYFPSVLRYNLPQFPFKPYEINKARHLYGLLKFPFYRLTADVNRCPSEKFSGLQEPVMPNECTLPGEHNIASEFVYQDGGALGSVDYIYAPSEVETGLAGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D7Y4</accession>
    <name>A0A061D7Y4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0300170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768298.1">
        <property type="nucleotide sequence ID" value="XM_012912844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D7Y4"/>
    <dbReference type="STRING" id="5866.A0A061D7Y4"/>
    <dbReference type="GeneID" id="24564653"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300170"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300170"/>
    <dbReference type="OMA" id="TICKNAI"/>
    <dbReference type="OrthoDB" id="364872at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40432" checksum="1A2C8D7A67A85EAD" modified="2014-09-03" version="1">MKFRGEFKVENLHHFVGCLLCLSKLANDHPDPMSAVLKISKKKVSVVIKTILSTDAYLEIDTAELFHSPYILEGREDDTIALNVSVSSLYETLNAAVNSEYAALKLKRNNQVASLSVTFPDPAFPSICITLDILITPAEEYAQAESVIPEIPPCSCNIGLTKFQSIICYLESANRIGNELTEFEVCRVSNRSISQRTDFGRTQDLQLLDNANQRGAKTSVISDTAYQGASTKTNAAATNRQSEGREVDADVDQSHSPILLKLRSPGILAELETAFYGLHSFSSHVGEESREYANKNPKTVLKTDAVYTICKNAIDSIIFSKHEALLVAAIPDDYVTAEWTYFIFSVIALDSCQMIFKLPNQVSETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D814</accession>
    <name>A0A061D814_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0101840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766041.1">
        <property type="nucleotide sequence ID" value="XM_012910587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D814"/>
    <dbReference type="GeneID" id="24562396"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0101840"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0101840"/>
    <dbReference type="OMA" id="HANIFFH"/>
    <dbReference type="OrthoDB" id="366133at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR93855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="221" mass="25137" checksum="8525B71AE64CA106" modified="2014-09-03" version="1">MLSDDDSGALPSPDTVVHFDLPKSPKALRGRCHPQHANIFFHLSHEKVLVAHLQNSLNCIMTKWQLPSKAEQAEAFLEHLATVVDSMHPLPVSVEYDSTDKRDSQLVVHISDNDSTCRALSALLYFAYRKHAHSKKQYLLHDPGFERFKTRRDVEAYLSENGISNYMGITLTRRGFVVESYDMLRQPMVHGSTPQLSGIRRIRERVKSGYISSHKGRTLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D881</accession>
    <name>A0A061D881_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0300970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768378.1">
        <property type="nucleotide sequence ID" value="XM_012912924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D881"/>
    <dbReference type="GeneID" id="24564733"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300970"/>
    <dbReference type="OrthoDB" id="365587at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="926" mass="103342" checksum="719D0C4843249DD2" modified="2014-09-03" version="1">MVEHVPPESVYRQPNVAELLASLTEQQTHLMETYKGFLDSMRLETNLQEAEGKLSGLKKAGAELIELQKEHITKLLIMLYPIFRVVMPPSQFEQDACIQMLGNRTQLEAYDLVELSCVLRCYFAKLAIYVYHMATFVKDWVAYEHAVSTDPNLHNHGVDLRPADSPESTEAFRTSFNANQAYSGKIYNAEETRANTYGMAAADAGATSSQCPSNLSIVTNVKRDETISARETSEISGDKLISDVQYCGGIVHQNLPFEYPEAQNHDPLYVSDSSEYYNSQTYDLLALHSDGDLDCVEDNLHHINHADAALFADSDRLEDYVQKRLDHEVGLPDITGEYLYSRRESSGTETGTFLDVTTRKLPLGVSYRGYDGLTRGEAYIGASRLSLDVNEQESKAVQPATMRPAFGPPDQLSQHGESEWNQHAPINAMNSREPRFGHDDSHSPRLPYPKPLLISQRSKSLLQPSGDVYEGTPLNKGQEGSNLREIHRVTSSGSDVSRSCDVLCCGVGCQGKGPKHVQTEMPILASETYHPSFYVQRSQVGQQLHVKGGGWNNKDVTYLFYQTPVPMFDLETMREADGSYRPASTNSSLCSMDDKTQQGGINSTVADHTQGNNGAHSTSDVFGELRYGVNGQCVNKSVFTSAQGTNFDDVPNHSDNIKNNNTEQRSGCVVPGYLPFSRSKEKVSYVTRFGAFDHELGIVSYDSNYRIRRVHAPLNDVFMDGVEHSHRSYSEDRDVKGSLASNFCRITQGAKQLGLRHLQLDVRLSQQDKLASETFETSDLEGSSCMDSLDILRHQLESIPSPEQDGGATSHDIEEKKERRNFREDRQEACGRSAVKLREIQCVAIPLPKQSERNEDHEALISAIENPECDYKAETANQPVHALKRIEHSVQPLHSPPRDAQEDNLSSSRIHIPPLDMSKLRARVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D888</accession>
    <name>A0A061D888_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0301020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768383.1">
        <property type="nucleotide sequence ID" value="XM_012912929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D888"/>
    <dbReference type="GeneID" id="24564738"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301020"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301020"/>
    <dbReference type="OMA" id="THTRREC"/>
    <dbReference type="OrthoDB" id="366119at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="731" mass="83803" checksum="3EB586F49742A3D1" modified="2014-09-03" version="1">MVQKRALDRTEDVFLFTKTHKIANVLDIEGDTQPRVPPATLISQDNTKMSIKFTDALRFVPMQVRLKVTNVTVPLDSSINLLKRDVLPPRALSHRMSRLCNPGTTDKEKTKSALLERKSVFISRNRVSRDNGLPQILRLELTNTVIVESINNLSTFPVLSVDYGSKYIGLSIHHMGKAKLLRSIYNTGDVEHLCGVVYSIVTDNIHPPSRFIILVGLPYSREEITGSEWISQTLYNLDFATRLSRYMHGRHLGTYGNWEHNVNHTNEKPMSPQHVVHNRCIGCSLNLGYCGYNNACEELFLIAPSDYSSTAVIGISEESSTYQTQIFGGRNHRRLDSLASDIIFRNLQESLNSDSNHRKPFLVLPSCNNLLRTHTRRECLLLEKTIFDKCVNLSHTRMPTPFHSHLFYEVFEILVRNGELTTLRRLLGVVATQETRLVATLLKNNNTMVPLDYMGLYSMQFLRALQNDHLAAASNVSLFIMYAQVFNEIHRQMEEVNDSERDTLRVYIHNLFDEMCTRFLDERILEDRSTLCRSSAKSMCYDLSGSCTMRILLNLAGYELFISKEKRTSIGEVVFSCITGYMKIITDETVYSGPQLTAFLTPPHSPFYVFHHEGDNVLQELLTPFESKPQNSSSPRRNHVSQSGNVLNDSMHLLLKFVTHALMEIVVVYRQSSNGDELTRVFTKFIGRVNNITLHWTHKKSFWDKVRRICSHQCSQYQKNEEWDAIETYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8B5</accession>
    <name>A0A061D8B5_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHF5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0102970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR93975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766161.1">
        <property type="nucleotide sequence ID" value="XM_012910707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8B5"/>
    <dbReference type="STRING" id="5866.A0A061D8B5"/>
    <dbReference type="GeneID" id="24562516"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0102970"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0102970"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR93975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12418" checksum="6D29DFD02DC21FD3" modified="2014-09-03" version="1">MGSKHHPDLIMCRKQPGISIGRLCEKCDGKCPICDSYVRPCTLVRICDECNYGTNQGRCVICSGPGVSDAYYCKECCQCEKDRDGCPKIVNLGSAKTDLFYERKKYGYKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8N7</accession>
    <name>A0A061D8N7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0302060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768488.1">
        <property type="nucleotide sequence ID" value="XM_012913034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8N7"/>
    <dbReference type="GeneID" id="24564843"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302060"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="129" mass="13691" checksum="74993308887E6176" modified="2014-09-03" version="1">MLHNLKWLKGKINKTQDGDAQPNDKTGASQRSENIKSETKSDDNASSPDPAIQDEATPTPEQNQPKEPNPTDVKQPTPSPVATDLQTIAVGDVTDALCGLPGNKVCGKGAMVVQIMRVSNATSTDLKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8P7</accession>
    <name>A0A061D8P7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA-processing protein 7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0308120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769094.1">
        <property type="nucleotide sequence ID" value="XM_012913640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8P7"/>
    <dbReference type="GeneID" id="24565449"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0308120"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0308120"/>
    <dbReference type="OrthoDB" id="360263at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="147" mass="16403" checksum="93FDBB099E25F81D" modified="2014-09-03" version="1">MFHAILDDEKAASKLMADSRRIDGAVINAKSHKSRDGPTFLSAALQRRRGQYRGMDILQKNADERLVTYDVEEYVAGRLEREVTVDDEGFTLVTQGPEAVKAGASRRPAKRSKKISTTTVEFYRYPNKEKMMYVAAGDIAEAADNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D8R0</accession>
    <name>A0A061D8R0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S12P, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BBBOND_0302360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768518.1">
        <property type="nucleotide sequence ID" value="XM_012913064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D8R0"/>
    <dbReference type="STRING" id="5866.A0A061D8R0"/>
    <dbReference type="GeneID" id="24564873"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0302360"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0302360"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR96332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="209" mass="23434" checksum="CFC13275B373F7B2" modified="2014-09-03" version="1">MGSGVPRGILAARKLKNRRRRERWADKAYKKAHLGTRWKCNPFKGSSHAKGIVVEKIAIEAKQVICFSYARRLLAIESQVVLPVGAIPPMGVKRLGTTYTNRSQRWPAPPLIHEAAFCYIFAQRRCYPNSAYRKSVRVQLIKNGKKITAFVPRDGCLNYIDENDEVLVAGFGRSGHSVGDLPGVRFKVVKVAGVSLLALYKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D962</accession>
    <name>A0A061D962_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP-like extracellular protein family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0311340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769417.1">
        <property type="nucleotide sequence ID" value="XM_012913963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D962"/>
    <dbReference type="STRING" id="5866.A0A061D962"/>
    <dbReference type="GeneID" id="24565772"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311340"/>
    <dbReference type="OMA" id="FAKRGNT"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="156" mass="17530" checksum="AC61574A0BC68DEE" modified="2014-09-03" version="1">MLAALNDYREFHSSPPLKWSDKLASSADKLAAELSRQLNCNIPLYYRNELGTNYLSAALDGFSEAVAAQFWYEGHTDYDFENGGPLNRNPNVLSFTQLVWKSSQEVGCGVACCDGRQVVLICRFNPPGNTQGHFTSNVQEKFERLNDVVKEVPYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D979</accession>
    <name>A0A061D979_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SNF2 helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0105790</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766456.1">
        <property type="nucleotide sequence ID" value="XM_012911002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D979"/>
    <dbReference type="STRING" id="5866.A0A061D979"/>
    <dbReference type="GeneID" id="24562811"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0105790"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0105790"/>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="98"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="405"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="736"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR94270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="941" mass="108593" checksum="B6C51698E2AED947" modified="2014-09-03" version="1">MKRGTAEATGSSRTEPRSDVQSPSAAKKPKTSLLHMLMHEDHFIEGILSNSRKTFSKMQPTPGASTANRKKGTVVTSQPTNLKGTAKPYQLEGLRWLVGLYDRNMNGILADEMGLGKTFQTISLMAYLKESRGINGLHLVLAPKSTIGNWINEINRFCPDLRALKFIGNKEERSQMMMNELDPRKYDVIVTSYETCCKTKSALCKLHFHYIFIDEAHRIKNEESKLSEVVRLFQTEYRLLITGTPLQNNLKELWALLNFLFPEVFSSAEEFEMEFDLVGPKELSQEEREARNLTIIARLHEILRPFMLRRSKKDVLTDMPPKNELLLMIPLSAMQKRLYKELLRKNVPELGAEDNHGSAVKVQLLNLAMQLRKACNHPYLFEGWEDREADPFGEHLVENAGKLNVVDKLLSRLLKANSRVLIFSLMARMLDILEDYCRMRGYQYFRIDGNTSGEDRDNQISSFNDPNSEVSIFLLSTRAGGLGINLATADVVILYDSDWNPQVDLQAIDRAHRIGQMKPVHVYRLVHEYTIEEKVIERATIKLQLDSAVIQSGRLGQKELLEMVQFGAGHIFKAGDEDITEADLDAILSKGQERANMLNDKLKAHTRKALLDFSTNPSTQQLYEYDVPEGEMQKLDQQAWDELTALRFQDESGSEGDARRRMRITTARMTEPDGRLAAKYTRNMLIQVILRKTLTSVNQDWQFFNKAELTKLDQLEQELGDLDDEQRIKRDRLLSQGFGEWTKKNFSAFIKANAQYSRYDIDAITSCIKGKSRDEVERYVKVFWKRYTDIPEWEKYIKRIELGEDILLKRNQLHQARHVFSDSHRAQMVLTKQRLLANPWVGTDALFAAHRGKCPFTEDEDRWMVNIIALLGYDMWDDLSELSRLDPRWQFNTFLRTRLPSEFAKRADYIIKHIAKEVGISSYIYIQLRRRAKNQAPETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9Q6</accession>
    <name>A0A061D9Q6_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">16S rRNA (uracil(1498)-N(3))-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BBBOND_0313230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Bond</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uridine(1498) in 16S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="3"/>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769607.1">
        <property type="nucleotide sequence ID" value="XM_012914153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9Q6"/>
    <dbReference type="STRING" id="5866.A0A061D9Q6"/>
    <dbReference type="GeneID" id="24565962"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313230"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313230"/>
    <dbReference type="OMA" id="WQTPFLE"/>
    <dbReference type="OrthoDB" id="2021042at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18084">
        <property type="entry name" value="RsmE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="RsmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046886">
        <property type="entry name" value="RsmE_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00046">
        <property type="entry name" value="RsmE family RNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027:SF3">
        <property type="entry name" value="16S RRNA (URACIL(1498)-N(3))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA small subunit methyltransferase E methyltransferase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR97421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="264" mass="29183" checksum="43605368BED8F3A8" modified="2014-09-03" version="1">MYVDITDKRRIAHLRYVLKADVGKELKFGVVGSTLDSATVTAVDPKVITVRLSEAFRSHQPPQQPVVDLVVGLPRPKSLDKLLQYAASIGVARIKLVCSSRVELDYLKSHQLEPESIEHSLMLGMEQGVTTFMPDIQLFKSMGALQRDLGKSQYSLRIIAHPGTPETLGSLQIVQHERGPILVAIGPEGGWLDHEVDYYEGLGFRKFNIGERILRAEVAAVAILSQLQLLLTDPTLRRGLPPATRGCDLEPDLKEARVIPHGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9T0</accession>
    <name>A0A061D9T0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0313580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769642.1">
        <property type="nucleotide sequence ID" value="XM_012914188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9T0"/>
    <dbReference type="GeneID" id="24565997"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313580"/>
    <dbReference type="OrthoDB" id="361538at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR97456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="368" mass="40938" checksum="E12830F71D6B09F1" modified="2014-09-03" version="1">MDGPVPSESAPETAASSVPSVPPTIQSSPSPEGAMVDIELSGKRAVHEGYVTWLKPWFDLSQSEYYRRCKACLISYMCLNFACVRVLELASLELRSMYRSAMCRMGIMHWLPEETLDVSITGQDPQGDPADEAPKDFLSPLQADNAIPSIPMGEMDVKSALISADGGDTTDNFGLGALEGYCDTNHHVFLTLRNMWHAPDLYAPFWINVMMSGSLFKIYALHQYYNGIVGNVLSLSMLLYFMVICWSCSFLMAVAIYLCRIFVCGSEGRTNFLPLLSVSGYMRIPLAIFCKVIVWISVARVYMPSLSGLIYFLQYLTYAYFCASTSATVCLFLPPSPDPAKDTVLKVTTAIVTCLVQTSYFYWIEVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061D9V4</accession>
    <name>A0A061D9V4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BBBOND_0306560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768938.1">
        <property type="nucleotide sequence ID" value="XM_012913484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061D9V4"/>
    <dbReference type="GeneID" id="24565293"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306560"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306560"/>
    <dbReference type="OMA" id="YRILMEC"/>
    <dbReference type="OrthoDB" id="10524508at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596128" evidence="2">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR96752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="340" mass="37204" checksum="852FC1C0335BA05E" modified="2014-09-03" version="1">MWPFWRLALLALHIANVSPADAAASRQQTTFWPSALPGLSQPEATLESLHLGPDDILTVSPEVDARAESSALSNAISSAPRPLSVVVLSDSPGELEKLRSDVESVLRLTRERQVDARDLGVTPPEISVKPPKSSPQTDTTSRLQILSVHYQRYTSSIPTLLVYLLAVPHACKFLYSGRAMARKHIPLVNTFSVYFIVFNLLAPLFGEGLVHSICCSLAANFAYRHAEGTHRLGMEAWFIVFEILCVCGIFANVSYRIGLGLLHLVVGRAHVPIWVSVCLPVLYPLHMLLVSSVCDASFGIHNAQLILAALIKVVPTYFAQELVLACSSLYIILSGTNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAH5</accession>
    <name>A0A061DAH5_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">-Golgi reassembly-stacking protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BBBOND_0400450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769739.1">
        <property type="nucleotide sequence ID" value="XM_012914285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAH5"/>
    <dbReference type="STRING" id="5866.A0A061DAH5"/>
    <dbReference type="GeneID" id="24566094"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400450"/>
    <dbReference type="OMA" id="FERAGEN"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="8">
        <location>
            <begin position="110"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDR97553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="322" mass="34989" checksum="A8C49D8DCB77D831" modified="2014-09-03" version="1">MGGNTSRVIPTGGLRVHRVYPNGPAEDVGFEIFFDYIMEADHNSYSDDSDETLMSFTSYISSKENQEISLNVYNARKKSLRIVKMTPRKWDGVGLLGLSVRFAEFTAMDEGAHVLKVHEGSPASKAGLIPITDYLLATNLQLFVDSDCVRVHVGERINEEVPLYVYNSITESIRKTVITPRNDWGGAGTLGCDLANGYIHRIPLVKGIYNVPSEAPSADYNDGSGELTLDLSTAGSTVETASNIVTEGQCNVISLSIDSSVTEDEESPEEPYLPPSIATVQNNSSLMENDEHDSSNSEESDSESSDSDSSDDGKETPKAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAP4</accession>
    <name>A0A061DAP4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0211260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768165.1">
        <property type="nucleotide sequence ID" value="XM_012912711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAP4"/>
    <dbReference type="GeneID" id="24564520"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0211260"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0211260"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="241" mass="27516" checksum="82B32A8BCC84049A" modified="2014-09-03" version="1">MRSTVADSSSRLRIRYKMSNDVLEDIRLLRLGLERWGLRKFSSHLLSDTGEPAQKAEQVLRQCWEESEGGPAESQSSTDGDEQPNYVVYGMLQVCLEHWQGTTSWQRGDKDVKSSRHKPTGPLSVVFNAVFISILKKIKLLVVHKHPDQFQRAVRHFTTVISRMFTGAYGSEFYQELEAEDLKLIVFLLRTLLSMFLDTQVDCLYPDGALPVFNVISGLRPQYLSGFEHDLITDFRDVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAQ7</accession>
    <name>A0A061DAQ7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0309750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769258.1">
        <property type="nucleotide sequence ID" value="XM_012913804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAQ7"/>
    <dbReference type="GeneID" id="24565613"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0309750"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0309750"/>
    <dbReference type="OMA" id="ECTANEP"/>
    <dbReference type="OrthoDB" id="10319722at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="142" mass="16256" checksum="40064489FA7C37ED" modified="2014-09-03" version="1">MDDRRIVFDADLDAYVDEGPSRPPICRHSRQCIASNGGIAPQEKYYTLPLSCIQNHCWIDKWSLATDKSHLQLQCGISLQLVLNELLRDSTITVHEYYEALKCFKQVRHRTMRSENLKRCRQSRATSIASKSCNSPIGAICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAR8</accession>
    <name>A0A061DAR8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0110870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391707">
        <property type="protein sequence ID" value="CDR94790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012766976.1">
        <property type="nucleotide sequence ID" value="XM_012911522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAR8"/>
    <dbReference type="STRING" id="5866.A0A061DAR8"/>
    <dbReference type="GeneID" id="24563331"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0110870"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0110870"/>
    <dbReference type="OMA" id="EAIETHM"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR94790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="284" mass="31357" checksum="1DC2D9A0D217EBE6" modified="2014-09-03" version="1">MSSTSTFVPPSDPPKYIGIDVDNTFHTHDVANFTKNKRAFRKLLESGYRPLFATGRPLHVAQYVLGELSTDGVYNGYPGVYQNGATVYNERGELVKEVKFSESFLRDFCAMVKSRSLEHIVVFLSASEMYALVEESACWQKMCEIWDLDTKLHVVSAEDILKSNIVQIMVSKYKDIRDHIPGVPDVDFMGKIGTCGLTDVNPPRVNKLEGLRALLGHELAESGNFAFIGDGSNDVEALQASQWSFAVGNASDSVKAAAKNVLEETNDQAAFAKMAQLLYGINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DAX1</accession>
    <name>A0A061DAX1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0310450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769328.1">
        <property type="nucleotide sequence ID" value="XM_012913874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DAX1"/>
    <dbReference type="GeneID" id="24565683"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0310450"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0310450"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="72" mass="8217" checksum="E7D9492D68D5C1E5" modified="2014-09-03" version="1">MWFCNSLCSTARQPSGTQTVFPAFLPTEFYYYIASHVSRFNARRGKLAHTQALSFSTNKSGSEEWPIFAIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB16</accession>
    <name>A0A061DB16_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">JmjC transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0403490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770047.1">
        <property type="nucleotide sequence ID" value="XM_012914593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB16"/>
    <dbReference type="STRING" id="5866.A0A061DB16"/>
    <dbReference type="GeneID" id="24566402"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0403490"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0403490"/>
    <dbReference type="OMA" id="FGAVNYH"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF113">
        <property type="entry name" value="PROTEIN JUMONJI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjN" evidence="4">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="234"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="743" mass="84225" checksum="7FE69D7891935ACE" modified="2014-09-03" version="1">MVSAREALSRKSSVSDSSFEPEYTRKRANCGADNVSGSDGQACRRSTRTTRRPSYFNVVHEARADRDTMAAIKRSRLETQELHMDYASFVNVPTIYANAEEFRDPVKLWHKYSRLGERYGAIKVVPVDGWRGTCPLDTDRVKFKVREQRIENLCNGKGFSHPSYSWDCERMKAEDTSLKNELFGCEDPSVEQVEHMYWALVKKGSGSLVVKYATDLNVYSREFKDAMVDVRGTAAETDVWNMRNLPKCPGSLLRYFDRVIPGVNSPWFYIGMCLTSFCWHTEDNYFGAVNYHHFGAPKATRLETLLKDYSAHESEEFALYSLRIQVPPDVLIANRIPVYRVVQRENEFVFAWPRAYHSGLNTGYNGNEACNIAPVSWLTMGYESLVNYKFIRKTCVSFYSLVMSGVCNYRDFGTADLARMIHSLSLLVSQEFTLRSSILYPMLQMYLHLDCPDVFDVQKFMDEACLQEFDAESYVEALKMLWSDDDDSFLRGCMLLSYVSMRDCDLCDTPTFGSCLMCLHCNCTVCISCQAYHPCNCDTRVVLYRYPLQAFNRIISILSARMHSLNDDDWQQMPVVAVPAASALSSIDASSVFSVDTLQKLLNSADDVFPFKSLPKSEGDVEPSASVFSSSSDLESVSTTDECFSCEPSKVFSLPYTMAWQSCWFDDLRAASERMRPADEVKVSEGESRYGEIALSQPFGVFRDVFASAKDARALALVTKLTVRYMMLSFEGDCSYASCNAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB63</accession>
    <name>A0A061DB63_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770107.1">
        <property type="nucleotide sequence ID" value="XM_012914653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB63"/>
    <dbReference type="GeneID" id="24566462"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404090"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404090"/>
    <dbReference type="OMA" id="NINCKFM"/>
    <dbReference type="OrthoDB" id="365957at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="391" mass="43156" checksum="5FA6B093409DFFA7" modified="2014-09-03" version="1">MCVDVTIQTPSLHLSSVRLSTLCTANFIRRFLLPHRLRVLSAEDFSYDGYTFSLSSDEGLYLQVRRVQTDVSCIEDAKGTMVCYDFVTVRMDVTDPGYLKDGSRLCERTMAALDRLPACAAVLSFGGDATESDVASVRADLCTADCAVTVMEPSVSTYNCSGKQESALLDASSLLSAVNEILETGRLPEPTAIAAPPDADDVVHGRSSRAHDEGKRRKVLSSEGEEIHIPDEFEHFLKHKELLFKAHRTLSNEKNRKLETIRNVMNELSKAAVHFVPEENFVQKLRHGVDMLLFRALTSRGNRATSTGPQDSGTEYVVSAMKGTLVPPEKMFDMFRSACEHLGAECPVFVLSATSARSPRQNAHSKELGRFSILMCSRSMQDPLSETSICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DB80</accession>
    <name>A0A061DB80_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770132.1">
        <property type="nucleotide sequence ID" value="XM_012914678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DB80"/>
    <dbReference type="GeneID" id="24566487"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404340"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404340"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="103" mass="10858" checksum="03F205F56BE2603E" modified="2014-09-03" version="1">MAYCSATFDAFAPHSDTSSAFQAATKESENVPSNASSNRVTPRLFSVSTSSTDTHVAIKAITDNTHTLPETVLSRPASESQPSAPDGVSTSLRPMQRSTGPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBB1</accession>
    <name>A0A061DBB1_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic aspartyl protease family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BBBOND_0311650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769448.1">
        <property type="nucleotide sequence ID" value="XM_012913994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBB1"/>
    <dbReference type="STRING" id="5866.A0A061DBB1"/>
    <dbReference type="MEROPS" id="A01.058"/>
    <dbReference type="GeneID" id="24565803"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0311650"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0311650"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595649" evidence="8">
        <location>
            <begin position="22"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="183"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="214"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDR97262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="648" mass="70271" checksum="3F8D468EF651EBBA" modified="2014-09-03" version="1">MRVTSAYAVVFAAAYLRCVHGLGDNLQSAAISRSQQCRGADCHRDVIIDAYAGADVAAIDKKATPIWNTPAQTLQRSLRAQYPRMLTSQLFMKPKYAIKLHRFTQLNNAKNRRKPGSDNNVHHTGKGSPAHEKTHTKVKGHDSSFIWQSAETATPPAETTTVSGGPGAQMLRQFLFNFENNQYFGEIEVGTPPSKFVVVFDTGSSQLWIPSKQCSSNGCARHRQFDSTQSSTYREPAPGSVASNAYIQYGTGECGMLVSDAPDDRAVLALGADTVRIGPLEVKNQSLGLATYESDHPFGDLPFDGLVGLGFPDAAFSADTDALPLMDNIVKQKLLNRNIMAFYMTKDRTQPGTLSFGSIDPMYVLPGHSPWWFPVVSTDFWEIEMDSILIDGKPMELQRKYNAAIDTGSSLISGPSEVVGPLLEKLSLSGDCSNAASLPTISFVFVDMLGRRIKFDMSPEDYLVRMDEDDADFGMHLATATSSGSSQPGEAAGDHGQRSDGNHDAGGGAARDTTASSEKGDATKSGRKADDGNDRDATSGGQQRTAAKAEWTPDMGTRCAVGIMAMDVPKPKGPLFVMGVSFINRYMAIFDRDAMAVGLVPSAHKQDDSDKQQLLEQDFEISSGERTSPVYNAAQRWASTRTPIQRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBN2</accession>
    <name>A0A061DBN2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clp amino terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BBBOND_0312550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769538.1">
        <property type="nucleotide sequence ID" value="XM_012914084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBN2"/>
    <dbReference type="STRING" id="5866.A0A061DBN2"/>
    <dbReference type="GeneID" id="24565893"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312550"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312550"/>
    <dbReference type="OMA" id="EFMEPHT"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="59"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR97352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111414" checksum="8C5BFBEDE3B65E18" modified="2014-09-03" version="1">MKHRGQHITAEAFRNDATSSSCRRFGSLLPSSNIRRRCYSTGDSSGQARSPDKRALLNFNNFSDNAVKVLMLSQEEARRASTTQIAARHIFQGLVCLDSGLAAHVLREFGVTVNTIRAAADNIFRVDTSNSNEALDTKLMTFSDEAKEALELSSVEAELLGHSAIETEHILLGLLRCRSEEVARLLNTLSLNPDEVRKLTLKYITEHKEKPEEVQQSDTWKQALSQYSYMPAQGRSVDVMKETYTSPLATFTVDITAKAELGKLPKVLCRDAEIDRAIRTLCRKHKRNPILIGEPGVGKTAVIEGLAMQLLKGGATPSLRHKRLRQLDLGLLVAGARFRGQFEERLTKLIEEVKTMKDVILVIDEAHMLVGAGAGEGALDAANLFKPSLARGEIQCVAITTPKEYRKYFEKDAALSRRFQPIYVNEPTDEDTKTILNATTEEYGKYHKVSYNPEAVAAALKFSKQFIQDRFLPDKAIDILDEAGALAKIRFHARTKSHQEDAGNSATTQDANNERSQTETAANTTQSDSQCSIDAGGMRGAESNGSTTQETNALSGISYGFAVKGDVDLQQTGSAGNEGGMCATISDSDGASGSSSSADSYYTEDSELESDMAEQSPAAPVCEVNTEHVAEVVSTWTGIPLQRLSEDEIEGLRNMESELHKRIIGHEEAVKHICKAIRRAKTNIKNPERPIGSFLFCGPPGVGKSEIAKALTNLLFASEKNIIKLDMSEYNEPHSISRILGSPPGYKGHDSGGQLTEKLRKNPYSVVMFDEIEKAHPNVINILLQVLEDGKLTDSKNQTVSFKNAVIIMTSNTGSNVIERASRGSHTFGFNIQDKPADESKNYSEIKSLVCEELKSQFKPELVDRIDDIIIFRPLTDQQLRQISKLMIEETLKRARDAGMDIVVDDSFVDFVLKLPRDEKGGARPIRRLITSNLEDKLAEFVINKDYEPGKRYRVAVDDQKHIVIRADNDTGKVYQKEPPQPVSPIVITEDNVENPLCVLHTLNEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBP8</accession>
    <name>A0A061DBP8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0404740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR97988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770174.1">
        <property type="nucleotide sequence ID" value="XM_012914720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBP8"/>
    <dbReference type="GeneID" id="24566529"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0404740"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0404740"/>
    <dbReference type="OMA" id="MEPSYLA"/>
    <dbReference type="OrthoDB" id="365750at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR97988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="867" mass="95575" checksum="547CA5ECAE5D47A0" modified="2014-09-03" version="1">MVPFIHSDNDASYAEYQGDQFSESREPMLPDNSTLEPLVLGESVAAVVAGENAFVEATQGEYRDDIVGMEPSYLADWTSWYELPTPRGSQDSYVAGLGNHFELPSTYTDYKSSDQFKVSDHYSASEQYSTPDQYSRPDALKSLDAYMLPGVYKEDDVLQPADVEGDFGRSQSIGLESSLYHLNPYETAMSSLGSFDACKNSASSSFDRREFVGGFDAISSSVCSSYDTPSLHCPASEVPSVGSKYRRSKSQNVDMGSQALSSLNDPSGYMPRVKVSQLRGSTKVRGKRGLGRVSTDDVATFNTHFEEYSKVFKRKMDSSIMFDNDAYEVPSRSALSMYVRSGDSSSTVAPTPATPATPATPATPATPATPASICYYDSSSETPNVPQLTGLGNLEPICSHDGAYVIRSKSVSRTPTINSPYMSARQQSFVEATADLTTYQSDLCSSIDGDHVKVDVVDSEIVYKAEEEPLNDFPRSPIDVLVEERRRAAMAERLVDVPVMHTRHGSYAKNIGGKRHVGLYGDRRASVRGGEYVVSSIDKDGSPVLTVVGSLLDSDKFKHGGVDGLDQFGGIVETMKEGETDNLDVDLFTLQQSFDGNHYIEDLGSQYDLTCEVAPPEETYVYIRKIQQGETATLTLHKEKVVATVTATSSELNDVLLACSTGASNYQPTVKWDQSRQAYVVTWWSSNEEGAIKDRQTRAFAAATYGKAAAYEEAVKFANFAETQIRPGALIRWYPGFNIPIGTSGRTNLRKVLHLDRMKNAELCDPVLAANGMKIAAKSTFGDMTIVELYKAAYVLGLWDIAAYNCLKTCKRRGYSYRWVHQLQLKGRRVTLDALKYLRNVRESLTVNKQSKRNNRSITRRAGRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBQ9</accession>
    <name>A0A061DBQ9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0312950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769578.1">
        <property type="nucleotide sequence ID" value="XM_012914124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBQ9"/>
    <dbReference type="GeneID" id="24565933"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0312950"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0312950"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="81" mass="8680" checksum="02544F1265589B59" modified="2014-09-03" version="1">MRLNAEGLGSGGTELINHLEEMTSMPTPYREANTAPAAIATRKPFVFDAEDGGPHVLDCGLPRSCAVRSTASKRYNSAMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DBW4</accession>
    <name>A0A061DBW4_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase Rpb5, N-terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BBBOND_0313690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR97467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769653.1">
        <property type="nucleotide sequence ID" value="XM_012914199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DBW4"/>
    <dbReference type="STRING" id="5866.A0A061DBW4"/>
    <dbReference type="GeneID" id="24566008"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0313690"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0313690"/>
    <dbReference type="OMA" id="VRDRGYF"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="5">
        <location>
            <begin position="132"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR97467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="190" mass="22171" checksum="555EC59E0761DFBB" modified="2014-09-03" version="1">MDDEEGRLFRCRRTCCEMLEDRGYFIPNQEKLETFQEFKARYELYDKVRSKMLLVASLKTDKNTKLLVYFADETKKTGVKPIRELTEKMEDHDIHRAILVTQNVLTPFAKDAILEAAPRNIIENFLETELLVNITKHELVPKHIPLTMDEKQTLLQRYKVKESQIPRIQAADPVARYFGLTKGQVAAPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC50</accession>
    <name>A0A061DC50_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0400940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769788.1">
        <property type="nucleotide sequence ID" value="XM_012914334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC50"/>
    <dbReference type="GeneID" id="24566143"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0400940"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0400940"/>
    <dbReference type="OMA" id="WIFHKEG"/>
    <dbReference type="OrthoDB" id="365132at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR97602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="893" mass="102256" checksum="50FD92047612856E" modified="2014-09-03" version="1">MARPESVLAMHKSYFCLHYLHDVRLAIDVALEHLKHCEDADLILTVLMEFLANHTSRDRPLELNTVRGVFAELLKSRNIVGLHRILVRHQYEHLMRQLNCRTLSDHRMKIVPPKALNVGTHHKRAVRRSISRRHLNLSLCRISLVRILRKSIEMNHYVATRSPGKYTATRLTKRRCYGNVDTLEKEFKKNLIDCFGDNALMYVRCESLCGPRTCKDGEYSCSIASTGVYDSVRYSNLQSDDRSAAEASNRHNTCTKGLLSVHGCICVSPPIPHPQLCVSADQSSVMFWWRSHYTMIKRKIFQVCNVLFININVPFIAVDLLSRFFQNAVATTGAGVRRCLLFLFNLVDRGGTADMQREAQSVTEDDTTLLFMVAANCIEIALNYNNGCARFDIFSLFYFLMFVDSIFTNLGYEECTNACLPSLMPALDRGAFLKQKLNGGAHSLRRSLKYHHGIFKRELAHLAKEIKKNRILQVVNFQIANCLEQLLLLSHGIFGLNLTLKVAPILFEVTRKAYRMYDFNRHRYEPDAHVYSYSSGRSGYSNPQEEGGCYNRVRSAWANLFQPYCGMSETTSTRHTTSDEHEQYEMDSNDSVKSWSSVLHSRAVSEPDPGASQAESEFANSLVTEFTELSILLLQMLSCSKYIEILVGNSMFASPGCRVSLATLMAGMCLHFVLDVYVMITDDLISNTLRTCHLSSSPIEGETAGAAYLEAFQRYMGCNYRLLAENNCALYFMVIELDWIFHKEGIYSRSEYGKHLRLMGSVLEVTSVFDRDSLEDAFEAHYRLYSQIAVTMFEGPHVDPQTALCVEAFKERVASWSTFDEVTIRRVNPEDELSINQDIMDIYYSDLRYPRHCFNPYKSIFTPKYFELAKDLVYRVKAALLLYYVRNRRTYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DC87</accession>
    <name>A0A061DC87_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0205580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767586.1">
        <property type="nucleotide sequence ID" value="XM_012912132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DC87"/>
    <dbReference type="STRING" id="5866.A0A061DC87"/>
    <dbReference type="MEROPS" id="C86.A05"/>
    <dbReference type="GeneID" id="24563941"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0205580"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0205580"/>
    <dbReference type="OMA" id="ICNLEQH"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="13">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="12">
        <location>
            <begin position="257"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR95400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="355" mass="40584" checksum="7F8F5327787CC3CE" modified="2014-09-03" version="1">MENVVYWEKQDPQSKLCALHCLNSFLQGPKVTNDELLNISTMLGRTESALLKTWGNRSSNVGASGYRYDSDGGDFDVTVLIEALRKRNFICNYYTVNDMKLSMFQKSENCGFICNANNHWFCIRMLLADQWFILDSLRPGPHEVEYGQLYSYISQLLNTKGGAVFLVYSATPGTKLPVAEPNKFSHLQSHQYYLTSEEIKEMNKENDNDEENKSFLYRAGVTKQKPVVWPTTGGIRLDQSVPKSVTFVPVKDEEDYKEADSRTVAVKINGTTRITRRFDPQCGVNEVFKWVEKHIESSDAAFYTLLQTVPNRRFVKYTNGSIEMIQQNDIPRDIGNTSLAEAGFESHEMFMLRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCB9</accession>
    <name>A0A061DCB9_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0305270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768810.1">
        <property type="nucleotide sequence ID" value="XM_012913356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCB9"/>
    <dbReference type="GeneID" id="24565165"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0305270"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0305270"/>
    <dbReference type="OMA" id="FKANQMS"/>
    <dbReference type="OrthoDB" id="364645at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="796" mass="88479" checksum="CB9BB406FD712BDC" modified="2014-09-03" version="1">MAVCDVSLVLGASGFACPSQCPYWSQSAVWKGVGVCTTAERCSVYNPRLTYADPVSRVCLPCDVYGCATCAYSQATSAAPVFRLNNAAGSATLAGSQPDSGVALPDVCLECAPGYRMADEGRSCYLVKSSIWSRSFYTMVAGITIALAALCVRLLVRPSLFRANLDRYRQELGSHRGGHGSSKLGRGIIGAMLALMNEDIAGIGVMLYFRFLAFVLGTTLVLLLLSVAHAHIPCSDMIRSLGEAFSLDRPDDVLVDPSWLSWLGFRRAPGWRQHLLNFRIVDDAITWSVSQYVEDNVRTMHVLYVAVMGITLAFAWSQHKFIREYFKRNPRVQSFTLVLERVPPFHTLEDFVENASGVRPKSVTVAYDIEKASEGLREFLDLQDDEASTGVYVNLDMALEHRRVLESLEPSGTAYAVFHTRMEMRKALISLNRSGICNARLCDVEPEDVDWYNIFEGDGLLRRAAEMTAAVCATQLFWTLVFFMPYAAYKLHAGSTDLFEALWLYMFTGVGNGLVAASIRKATEKVQFASVQSAESYNMWLSTLAELLNVGLNVLLAHFNNYGGHYKVLSMVKDFALYKRTATFSVGEEVSITQSLSTYMVNVILLVPAMAFVLVRYGTPLMGALYVLAADLDGRVSHLLRPAPFELNGRYGSAVVNFTFSLLLQYVIRSRMQSFIIAFALLASYAVHYVIDAYVLINKAEPSRLTGTTAFRNALMMWAVPTGILAACPSYWRWRGMDGYLATSFVIFGLHVFFYCTFIYFICRPRDHLEGAEDNTSPSDYSIHNPVYKLRRLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCI7</accession>
    <name>A0A061DCI7_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0306430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768925.1">
        <property type="nucleotide sequence ID" value="XM_012913471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCI7"/>
    <dbReference type="STRING" id="5866.A0A061DCI7"/>
    <dbReference type="GeneID" id="24565280"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0306430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0306430"/>
    <dbReference type="OMA" id="GYKAWYM"/>
    <dbReference type="OrthoDB" id="359536at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="124" mass="14238" checksum="5F2295635321FB18" modified="2014-09-03" version="1">MGWHLQRYIAKAGRAVNPLVWKRVWKENEGKQLNDVASRVAQQLNDEIAQVARVSQYRYWWWANPLGAGLICYGVYKVWYMSYMAHKQRTGTFGGLCFVHYFAVAQIVAGAYGQGGQWLNPVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCJ2</accession>
    <name>A0A061DCJ2_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0207600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012767791.1">
        <property type="nucleotide sequence ID" value="XM_012912337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCJ2"/>
    <dbReference type="GeneID" id="24564146"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0207600"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0207600"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001600269" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR95605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="150" mass="16485" checksum="2F7A79FEA942B674" modified="2014-09-03" version="1">MKSVAIVFFALCAALRCFGINPAASRQEARESFGMDDVLNNIQQVGSDKEHDDSRLQQFSALLETAGIPVKDPESMEQHEKDVYDRIEALVGKSNARIITYIASIAEHTQSKSGNRPNASSHQASGFLLEQILAALEAQGSDFNFLKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DCR0</accession>
    <name>A0A061DCR0_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like superfamily protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BBBOND_0307330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769015.1">
        <property type="nucleotide sequence ID" value="XM_012913561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DCR0"/>
    <dbReference type="STRING" id="5866.A0A061DCR0"/>
    <dbReference type="GeneID" id="24565370"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0307330"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0307330"/>
    <dbReference type="OMA" id="PQIVECA"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="78"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR96829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="320" mass="36884" checksum="DFB632561955EE90" modified="2014-09-03" version="1">MADSEAKDAVVWPQKSTHFSRWLLPSASSLQEQQQRAFTAALARVKGREEHKEAELPTLEDELWLVRFYAFQLSRFMAANHLKDSVKETALTFFNRFYLRRSMLEYDPRLIMFTCITLAIKLEDMWRNYYVDKLLGSVEGLDIAGVFALEATVCDALEFNFLVLHTSDSMHTIRMRCMEYLKESLGIDDEILGEHLGMILSVCSDAEKDALYMHEDPEFIFLHTPTQLAVANFARHCKKRMGSLLSVSKWVPRCTHGRGVRFLAKKMLHGDESRLAVLTETLQSINDRFARHMELRASMDAEEQKAGNILDQYLPLYSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD05</accession>
    <name>A0A061DD05_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA recognition motif. (A.k.a. RRM, RBD, or RNP) domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0405960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391711">
        <property type="protein sequence ID" value="CDR98112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012770298.1">
        <property type="nucleotide sequence ID" value="XM_012914844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD05"/>
    <dbReference type="STRING" id="5866.A0A061DD05"/>
    <dbReference type="GeneID" id="24566653"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0405960"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0405960"/>
    <dbReference type="OMA" id="VYDAYCP"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="339"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR98112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="422" mass="47979" checksum="5263D01913F5C52D" modified="2014-09-03" version="1">MAARKTLKATVPKKPKAAAVKKTGEKTIKKAPFAESRTPRVVKQDMCKDNQPTDNPELELQSEASNDSAAALVGEKHACADMNRVQEIITDDVTPQLESCTVAGEDNCAAVEMDEEQAISPLDDQQNQQADENDVQYEEEKIAAFRLFVSKLAYEATREDLEDYFSQFGVLIDIHIPRQPGNPALNKGYGFVSFENEGDLLKVLEAPSHVILGRDVMIDRATGQKYHSSTKAMDDTSTRYRDIYPRYKRQYDEKDLRLDRYYRKEREDHYRYSYYGSDRGSYASPVSYSRTYSGFDPHKPVSYVFSGSSKPEHYGDIEYDNRYNTRASLPPKTRPRTVPKLFIGRLGPETTVGTMRNYFSQFGEIADAYIPRDSYTQKSKGFGFLTFAHKDALHAVMEPNAKHYIDGKEVVVDYADTSTRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD26</accession>
    <name>A0A061DD26_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">26S protease regulatory subunit 6A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0210430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR95890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768076.1">
        <property type="nucleotide sequence ID" value="XM_012912622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD26"/>
    <dbReference type="STRING" id="5866.A0A061DD26"/>
    <dbReference type="GeneID" id="24564431"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0210430"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0210430"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000183">
        <property type="entry name" value="26S protease regulatory subunit 6a, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="197"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR95890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="429" mass="47987" checksum="CB1064B1EB9D13B1" modified="2014-09-03" version="1">MDEVNEPIDLSEVVLMSDAEVRARINMIDAEIKILKSEHTRLKSRQITMQERIKDNQEKIQLNKQLPYLVSNVVELLDLEDEEEDAGVQGIEMKRKGKSLVIKTSTRQTIFLPVIGLIPHTMLHPGDLVGVNKDSYLVLDKLPPEYDNRVKAMEVCEKPIEDYSDIGGLDKQIQELIEAIVLPITHKALFEKIGIKPPKGVLMHGPPGTGKTLLARACAAQTKATFVKLAGPQLVQMFIGDGAKMVRDAFNLAKEKAPTIIFIDEIDAIGTKRFDSELSGDREVQRTMLELLNQLDGFSSDDRVKVIAATNRPDTLDPALLRSGRLDRKIELPHPNEGWFSPHFGHVVSEARAHIMQIHSRKMNVHPDVNFLELARSTEDFNGAQLKAVCIEAGMVALRRGAKELDHNDFVEGIAMMSAKKKTTLNYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DD91</accession>
    <name>A0A061DD91_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BBBOND_0212070</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
                <person name="De Silva N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Bond</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="LK391708">
        <property type="protein sequence ID" value="CDR96065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768251.1">
        <property type="nucleotide sequence ID" value="XM_012912797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DD91"/>
    <dbReference type="STRING" id="5866.A0A061DD91"/>
    <dbReference type="GeneID" id="24564606"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0212070"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0212070"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="20"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="19">
        <location>
            <begin position="548"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR96065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="716" mass="79170" checksum="A9C2E5CFD43ABA8D" modified="2014-09-03" version="1">MSEDRRSRIAPPWATDSRTLLALIALQGFLLRLFSAVKHEVVLHEYDPYFNYQCAKFMLRHGLRNFWKSFDDGSWYPFGRAVGQTVYPGLMLAAYAAHQALQYIGVDVDLKTVCVFLPAVLSAGTVYAVYLLAKEISHNECVAVTSAFFVGPMPALVSRTTAGTQPADQHNSRTAGAFDNEAVAIMLMVMSLYAWLRAVRDASIARSAGAAVTTFLMALSWGGYVFVVNAIAAFTLAAVLLRASAESVCAVYIVYHALTVALCFSVPMISNAVLGTMEMRLPHIVFSLAITTLSVSYTTKRWLRCRPANVGNGEQPPATNRGEGTHGAKEAVDGVESANERARFNWAIALGPAAAAVWLILVGRYHESESSLTARLLALLKPGNATSANPLVASISEHQPTKWKSMVLDFWVTLIYNPIGLLACFKNGIEIGYLALAIYGVVSSYFASAMVRLGLIFAPAAAILSGLGLSYTMEGCALNRKNRAASVALTVVTGVIMMSYVTHCTWVASTIYSNPNVVASWRSQNGERLVADDFRDAYSWIRHNTPRDAVVMAWWDYGYQLRQMANRTVLTDNNTSNYHQIALTAMIFASEEEHAHRMLRDLNVHYVMVVYGGVAKYATDDVSKFGWMTRIASTEFPQVHHSRFKGEQGEKYWRRTLLYKLCYHGVLQVAANDNVRGKPLPNEPIELTHFTEVMTSENWVVRVYRVNGEVEQDSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDA8</accession>
    <name>A0A061DDA8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">tRNA modification GTPase TrmE, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BBBOND_0300150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Bond</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768296.1">
        <property type="nucleotide sequence ID" value="XM_012912842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDA8"/>
    <dbReference type="STRING" id="5866.A0A061DDA8"/>
    <dbReference type="GeneID" id="24564651"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0300150"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0300150"/>
    <dbReference type="OMA" id="EFHCHGG"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001595723" evidence="7">
        <location>
            <begin position="17"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="9">
        <location>
            <begin position="48"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="8">
        <location>
            <begin position="283"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="220"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDR96110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="535" mass="59586" checksum="21F58E5BAC9EF431" modified="2014-09-03" version="1">MRCLFGILLFVTVAEAWRISKWDNFKLFPAAHTRHLSSSARAQFSAQTVYGLSSAIPDGGCGIAVTRISGRQSLKVLELLTKNEAARDSKSAFKCVPRMATLRTVYDQAKFTPIDKAITIYFPGPNSYTGEDVVEIHTHGSRAIVSQLFAALRCISRRHDIGIRQAERGEFTRRAFYNGKMDLTQAEAIRDIISSETALEMQNAALKLHGGLTQLYGTWADRLNQLLATVEARIEFDEQALADLNATHKEQTALLQGLTQIQEEIEAQLEDSKGEILTSGANVSILGPPNAGKSSLMNAICDRRVAIVSDMPGTTRDLIQVKYDLNGLKVTFVDTAGIREMGDNVEAISHNEVEKQGIEKALQHLNDTRLAIFLFDHTNVEHSQYALDTTLQNVPHDSQLIICVSKVDLITTAQMTQYMRTLESRYGPRAQITSISNREPQSIEAMLQLVHQNLEKDLSHVQKQPFVTDARHKSHLRNVLQQIKIALKSMANTQSDLEIVAENIREATSQIGYILGEQTNEHVLDAIFRTFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDD6</accession>
    <name>A0A061DDD6_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP synthase mitochondrial F1 complex assembly factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BBBOND_0301000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768381.1">
        <property type="nucleotide sequence ID" value="XM_012912927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDD6"/>
    <dbReference type="STRING" id="5866.A0A061DDD6"/>
    <dbReference type="GeneID" id="24564736"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0301000"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0301000"/>
    <dbReference type="OMA" id="WREYHEG"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDR96195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="212" mass="24836" checksum="DFB371D7F49E048D" modified="2014-09-03" version="1">MAGSDFYSRIKCVFGNCYGNNRSRRFMSFMYPVPRILNEIAKVPLLMRCDTQTIAGIWAQQFERRDNVVVMTLGGQVFQQLSKNAKRSPMFVLPVQVETRGTYNMILQHVDSKSVLFTSVHSFKSYGMEKSSPHFILTFYDELLVQKNIILVRGDIVNPTDVSKSNAKKLMEHTVKFYSDINLYKWVDCFNNRPREFEFEDFKRKCKHILEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDP8</accession>
    <name>A0A061DDP8_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0303540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391709">
        <property type="protein sequence ID" value="CDR96450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012768636.1">
        <property type="nucleotide sequence ID" value="XM_012913182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDP8"/>
    <dbReference type="GeneID" id="24564991"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0303540"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0303540"/>
    <dbReference type="OMA" id="FFCYPID"/>
    <dbReference type="OrthoDB" id="364759at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR96450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="301" mass="33611" checksum="5F5AA27F98BC8445" modified="2014-09-03" version="1">MFMGSSSFISMGKALKKKTPSTNADARRLMFVDSSIKAEFVEIVQLPNPTNLLDGALYAVLDGTIYLIRGILPNVHPVSLFVDNTILNQSFLATFRFDVIFIFTSILFLAPDKFMSMPQRIYELYRSGLNESQGHGALEAGAFALWNNNVDKIQERIRYLCDIANPGEAKDVVIKPNVSKFQAMLEYKVQSLEKAVRSSNIIMGSYCQSKETSNSEHVRKHYITVQDGKLRSFAWSLISSMLNAEARNRLVPSNGSMIDHQAIDDVNLSRKPVITSSKRPKQRKIAVASGTASITSFFKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDQ4</accession>
    <name>A0A061DDQ4_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BBBOND_0401010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bond</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769795.1">
        <property type="nucleotide sequence ID" value="XM_012914341.1"/>
    </dbReference>
    <dbReference type="STRING" id="5866.A0A061DDQ4"/>
    <dbReference type="GeneID" id="24566150"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401010"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401010"/>
    <dbReference type="OMA" id="DFGALWF"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="605"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1602"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1111"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1602"/>
            <end position="1614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR97609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="1658" mass="181857" checksum="803B0F4B36E3E446" modified="2014-09-03" version="1">MSDDVVDGTLGPLLGVEDWIEFLRHRGELNYHFQSGQYAEEASLLLKGVNGGVGAGKGNGRRSIRKGQPPAPSADICEVHRDAEKNATEYSDNLNSDNVDECPSSNEICLDLPLHPLAEGDRRPTLVEGDEDDSAFKNTKYNSLEIGLVDSNASQSGAPDASYGLQGPNSDSGRSNSAATPVAEIDEMNALYPWGALNRDVLISARNSGLEPTTLGHVLKRRNKLWAKTQCIHKSAKADFEKHLRLYQRQFETYSKSGDGWVNVNDDRKTDPIFLRESTYLTGARNVRKVMRQVSADMSMGDADSSEVVNAKATGGRSSRHKCNALKGVYDWNNVIFCPNIFDSSDLIHRHGRRTVRLYKNLYDCLVHGWVHPGLVVCEVKDATHPIRFATPTEQDCYTVVYAGPRIPEHSTQRVVFGEYTGVIYREGSLSDSVFEYAFELNFAPCAWINAEIEISEDTAEIGQNGDLVLLPSNAKFVLDSSHACNELSLVNHYQSVKAYGGEKWVAPNCEWQQVFLDGWPHVVLTSKLGVAVNPGDELVADFGALWFSKVEENAHKFIRNEIIEYRLGRATGPPTQNQVEVPQRPLSSIDIGLVSNSIATSVPVCVICHNIGDDNGDHSSPDESDSVSCDGCDRFFHMTCLRNINLVSAVQMVKDGIGHAWLPSTTCKGIPQGSGKFYCNFCRHLAKKIYMHDTGCDYMPLSSGVNVNTQNGLTGTFDSQNHLQRDHQAENRDANHADETTRNTSLPTGDDVISENNGNSMHTIVPDKTYPVQQGDIFQLCERPDGGEVVESAATNDAVICPTRFPSSKLRPEEETYVCNSGPKLLMQPLKTPSMHDFAIASQYKLQLQSGNILGQNNNRLPVKSTGTYASDLLGASEKRLDTDCSRQRRVSGVSEGDAMGLKIAEKCADRTSSSLQVNKPSHCPTCLRHFSPPENMGKAVHEGLDASSQPVPPLSTSKCENGDVSHLEANLHSGNVSSAGDFSNFVPLVAGAADKEALSNTGPDAAPDALEQEKPLDTVILDAERTNNAAPSHDSIGSLHPSCDSEALSFSQMEGHSETMKAFQTPTDYPSTSDVNIFAGGSISNQMHSTANTGSEEYPHNAPSTNAGKDPKDDKTDESVFNSKSPAGCNVTASGDKDSASTMPLPGGSPGRAETHITTANIDRAVYFYKTLGNQMKLPPLTALSEFDCCAPQGDDTTMADYLGCKYLAGMWQIEPFAMFGDSVRVCGECYEKYGSKANVYVCRLLRRHLSGNYDHPMNTTPAQMRELVLMAYEQHVQMLLRLLVLKNVAIQFMCRLCCHFVSRQLFHQKQDIFPPLPFPSHFMGEDSGNPEGVLADPSGLLSGVRTSGARAMKANQKKVLQSHLSSFVTSVKNAVCNLPLSSKSDPALNYELLSAMGAFSDEFSRLANCQNIVEYLNDLMSHKVLDADNTPSQLQQMLTKDELRRFFAFRHLAERSPGPFGPSQSSQVRVRKRDRGPTFIPLIGIVPGRSFIYRHFKDGYYRGLVTEYLEDSVLGKHSFLVAYSDGDDETLSQKDLIGEIVDNLHNIEGVLTNLSQNDTRNEEILLRMRSYGDQSLGALCSELRREMLHNLMLHQTADPYKRSESSKKHSPDLTNAASETAAVDVDSSVTQHGSPQPVYPTPAASVDETNEITPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DDQ7</accession>
    <name>A0A061DDQ7_BABBI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit NCLN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BBBOND_0401060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
                <person name="Pain A."/>
            </authorList>
            <dbReference type="PubMed" id="24799432"/>
            <dbReference type="DOI" id="10.1093/nar/gku322"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Bond</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="EMBL" id="LK391710">
        <property type="protein sequence ID" value="CDR97614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012769800.1">
        <property type="nucleotide sequence ID" value="XM_012914346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061DDQ7"/>
    <dbReference type="STRING" id="5866.A0A061DDQ7"/>
    <dbReference type="GeneID" id="24566155"/>
    <dbReference type="KEGG" id="bbig:BBBOND_0401060"/>
    <dbReference type="VEuPathDB" id="PiroplasmaDB:BBBOND_0401060"/>
    <dbReference type="OMA" id="QNFRTHI"/>
    <dbReference type="OrthoDB" id="5913609at2759"/>
    <dbReference type="Proteomes" id="UP000033188">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016574">
        <property type="entry name" value="Nicalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001596061" description="BOS complex subunit NCLN" evidence="12">
        <location>
            <begin position="21"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="13">
        <location>
            <begin position="261"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDR97614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000033188"/>
        </source>
    </evidence>
    <sequence length="593" mass="64907" checksum="4E5584D95B05DD42" modified="2014-09-03" version="1">MKAAVVSLLLSAILPLYVEGATELEVHRLSGFTLNDKSYGFPDALYYGRIANVRSLYRDLASQSTEMTDAALEDALAKRMHKNGYTLMFRLQDVLQNRLDFASFRTLLKSSGSTAMLLIPPPSNILPGSPQGCTESPMLDSISGENLPVCKYDTPLFHQSTMSAFHEFLLNCDPKSLLAVVEEGEDALTVMREYASGVAPLGAVNRYRITSSTYKSVSNYKSLNIFGTLRSAHNEGVGDNAATDSSGNSSKEHDNEGAPVKPKIVLCSHFDTFSLLQSYRAAASNNAGLIALLELAHLLVGLDHHSYEVVVLLTSGSILNFQGAATFANSYPNITNVELVLCLDDLTGPELYVHTSSKSTAFSHFFQEHLSRSVSDTIKRGVNTKAKLLSFQHEQFSRQKVHSITLTSVKDSVALPLRQRSFEYSCDASVLANHVIAIAQALASALHCGPLAVDASEVQSRITSWEAKLGNPRCGLTHDLHKDKAVASIVDHLRPLLETISTQHVTSKVVDFGFNANKPMRVAFYRNRTTVYHVCVLLASVVYIFVMWSIIRASPKVAFTDIMETIYGASPSKQQDSPDAKPIGRSQSKHKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061DE09</accession>
    <name>A0A061DE09_BABBI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BBBOND_0403420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Babesia bigemina</name>
        <dbReference type="NCBI Taxonomy" id="5866"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Piroplasmida</taxon>
            <taxon>Babesiidae</taxon>
            <taxon>Babesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="7113" last="7131">
            <title>The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Otto T.D."/>
                <person name="Darby A."/>
                <person name="Ramaprasad A."/>
                <person name="Xia D."/>
                <person name="Echaide I.E."/>
                <person name="Farber M."/>
                <person name="Gahlot S."/>
                <person name="Gamble J."/>
                <person name="Gupta D."/>
                <person name="Gupta Y."/>
                <person name="Jackson L."/>
                <person name="Malandrin L."/>
                <person name="Malas T.B."/>
                <person name="Moussa E."/>
                <person name="Nair M."/>
                <person name="Reid A.J."/>
                <person name="Sanders M."/>
                <person name="Sharma J."/>
                <person name="Tracey A."/>
                <person name="Quail M.A."/>
                <person name="Weir W."/>
                <person name="Wastling J.M."/>
                <person name="Hall N."/>
                <person name="Willadsen P."/>
                <person name="Lingelbach K."/>
                <person name="Shiels B."/>
                <person name="Tait A."/>
                <person name="Berriman M."/>
                <person name="Allred D.R."/>
[document cut: first 30727098 of 33322602 characters kept]
